id	sid	tid	token	lemma	pos
cord-260577-t4w4pw12	1	1	key	key	JJ
cord-260577-t4w4pw12	2	1	:	:	:
cord-260577-t4w4pw12	2	2	cord-260577-t4w4pw12	cord-260577-t4w4pw12	NN
cord-260577-t4w4pw12	2	3	authors	author	NNS
cord-260577-t4w4pw12	2	4	:	:	:
cord-260577-t4w4pw12	2	5	Imai	Imai	NNP
cord-260577-t4w4pw12	2	6	,	,	,
cord-260577-t4w4pw12	2	7	Yumiko	Yumiko	NNP
cord-260577-t4w4pw12	2	8	;	;	:
cord-260577-t4w4pw12	2	9	Kuba	Kuba	NNP
cord-260577-t4w4pw12	2	10	,	,	,
cord-260577-t4w4pw12	2	11	Keiji	Keiji	NNP
cord-260577-t4w4pw12	2	12	;	;	:
cord-260577-t4w4pw12	2	13	Penninger	Penninger	NNP
cord-260577-t4w4pw12	2	14	,	,	,
cord-260577-t4w4pw12	2	15	Josef	Josef	NNP
cord-260577-t4w4pw12	2	16	M.	M.	NNP
cord-260577-t4w4pw12	2	17	title	title	NN
cord-260577-t4w4pw12	2	18	:	:	:
cord-260577-t4w4pw12	2	19	The	the	DT
cord-260577-t4w4pw12	2	20	renin	renin	NN
cord-260577-t4w4pw12	2	21	–	–	:
cord-260577-t4w4pw12	2	22	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	2	23	system	system	NN
cord-260577-t4w4pw12	2	24	in	in	IN
cord-260577-t4w4pw12	2	25	acute	acute	JJ
cord-260577-t4w4pw12	2	26	respiratory	respiratory	JJ
cord-260577-t4w4pw12	2	27	distress	distress	NN
cord-260577-t4w4pw12	2	28	syndrome	syndrome	NN
cord-260577-t4w4pw12	2	29	date	date	NN
cord-260577-t4w4pw12	2	30	:	:	:
cord-260577-t4w4pw12	2	31	2006	2006	CD
cord-260577-t4w4pw12	2	32	-	-	HYPH
cord-260577-t4w4pw12	2	33	08	08	CD
cord-260577-t4w4pw12	2	34	-	-	HYPH
cord-260577-t4w4pw12	2	35	07	07	CD
cord-260577-t4w4pw12	2	36	journal	journal	NN
cord-260577-t4w4pw12	2	37	:	:	:
cord-260577-t4w4pw12	3	1	Drug	drug	NN
cord-260577-t4w4pw12	3	2	Discov	Discov	NNP
cord-260577-t4w4pw12	3	3	Today	today	NN
cord-260577-t4w4pw12	4	1	Dis	Dis	NNP
cord-260577-t4w4pw12	4	2	Mech	Mech	NNP
cord-260577-t4w4pw12	4	3	DOI	DOI	NNP
cord-260577-t4w4pw12	4	4	:	:	:
cord-260577-t4w4pw12	4	5	10.1016	10.1016	CD
cord-260577-t4w4pw12	4	6	/	/	SYM
cord-260577-t4w4pw12	4	7	j.ddmec.2006.06.012	j.ddmec.2006.06.012	DT
cord-260577-t4w4pw12	4	8	sha	sha	NNP
cord-260577-t4w4pw12	4	9	:	:	:
cord-260577-t4w4pw12	5	1	66a4c3bf2b1005264a8c3195f3aa5690706121ac	66a4c3bf2b1005264a8c3195f3aa5690706121ac	CD
cord-260577-t4w4pw12	5	2	doc_id	doc_id	CD
cord-260577-t4w4pw12	6	1	:	:	:
cord-260577-t4w4pw12	6	2	260577	260577	CD
cord-260577-t4w4pw12	6	3	cord_uid	cord_uid	NNS
cord-260577-t4w4pw12	6	4	:	:	:
cord-260577-t4w4pw12	6	5	t4w4pw12	t4w4pw12	.
cord-260577-t4w4pw12	7	1	Angiotensin	angiotensin	NN
cord-260577-t4w4pw12	7	2	-	-	HYPH
cord-260577-t4w4pw12	7	3	converting	convert	VBG
cord-260577-t4w4pw12	7	4	enzyme	enzyme	NN
cord-260577-t4w4pw12	7	5	2	2	CD
cord-260577-t4w4pw12	8	1	(	(	-LRB-
cord-260577-t4w4pw12	8	2	ACE2	ACE2	NNP
cord-260577-t4w4pw12	8	3	)	)	-RRB-
cord-260577-t4w4pw12	8	4	counterbalances	counterbalance	VBZ
cord-260577-t4w4pw12	8	5	with	with	IN
cord-260577-t4w4pw12	8	6	ACE	ace	NN
cord-260577-t4w4pw12	8	7	and	and	CC
cord-260577-t4w4pw12	8	8	functions	function	NNS
cord-260577-t4w4pw12	8	9	as	as	IN
cord-260577-t4w4pw12	8	10	a	a	DT
cord-260577-t4w4pw12	8	11	negative	negative	JJ
cord-260577-t4w4pw12	8	12	regulator	regulator	NN
cord-260577-t4w4pw12	8	13	of	of	IN
cord-260577-t4w4pw12	8	14	the	the	DT
cord-260577-t4w4pw12	8	15	renin	renin	NN
cord-260577-t4w4pw12	8	16	–	–	:
cord-260577-t4w4pw12	8	17	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	8	18	system	system	NN
cord-260577-t4w4pw12	8	19	(	(	-LRB-
cord-260577-t4w4pw12	8	20	RAS	RAS	NNP
cord-260577-t4w4pw12	8	21	)	)	-RRB-
cord-260577-t4w4pw12	8	22	.	.	.
cord-260577-t4w4pw12	9	1	The	the	DT
cord-260577-t4w4pw12	9	2	importance	importance	NN
cord-260577-t4w4pw12	9	3	of	of	IN
cord-260577-t4w4pw12	9	4	RAS	RAS	NNP
cord-260577-t4w4pw12	9	5	in	in	IN
cord-260577-t4w4pw12	9	6	acute	acute	JJ
cord-260577-t4w4pw12	9	7	respiratory	respiratory	JJ
cord-260577-t4w4pw12	9	8	distress	distress	NN
cord-260577-t4w4pw12	9	9	syndrome	syndrome	NN
cord-260577-t4w4pw12	9	10	(	(	-LRB-
cord-260577-t4w4pw12	9	11	ARDS	ARDS	NNP
cord-260577-t4w4pw12	9	12	)	)	-RRB-
cord-260577-t4w4pw12	9	13	has	have	VBZ
cord-260577-t4w4pw12	9	14	recently	recently	RB
cord-260577-t4w4pw12	9	15	re	re	VBN
cord-260577-t4w4pw12	9	16	-	-	VBN
cord-260577-t4w4pw12	9	17	emerged	emerge	VBN
cord-260577-t4w4pw12	9	18	owing	owe	VBG
cord-260577-t4w4pw12	9	19	to	to	IN
cord-260577-t4w4pw12	9	20	the	the	DT
cord-260577-t4w4pw12	9	21	identification	identification	NN
cord-260577-t4w4pw12	9	22	of	of	IN
cord-260577-t4w4pw12	9	23	ACE2	ACE2	NNP
cord-260577-t4w4pw12	9	24	as	as	IN
cord-260577-t4w4pw12	9	25	a	a	DT
cord-260577-t4w4pw12	9	26	receptor	receptor	NN
cord-260577-t4w4pw12	9	27	for	for	IN
cord-260577-t4w4pw12	9	28	the	the	DT
cord-260577-t4w4pw12	9	29	SARS	SARS	NNP
cord-260577-t4w4pw12	9	30	-	-	HYPH
cord-260577-t4w4pw12	9	31	coronavirus	coronavirus	NN
cord-260577-t4w4pw12	9	32	.	.	.
cord-260577-t4w4pw12	10	1	Recent	recent	JJ
cord-260577-t4w4pw12	10	2	studies	study	NNS
cord-260577-t4w4pw12	10	3	have	have	VBP
cord-260577-t4w4pw12	10	4	demonstrated	demonstrate	VBN
cord-260577-t4w4pw12	10	5	that	that	IN
cord-260577-t4w4pw12	10	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	10	7	protects	protect	VBZ
cord-260577-t4w4pw12	10	8	mice	mouse	NNS
cord-260577-t4w4pw12	10	9	from	from	IN
cord-260577-t4w4pw12	10	10	acute	acute	JJ
cord-260577-t4w4pw12	10	11	lung	lung	NN
cord-260577-t4w4pw12	10	12	injury	injury	NN
cord-260577-t4w4pw12	10	13	as	as	RB
cord-260577-t4w4pw12	10	14	well	well	RB
cord-260577-t4w4pw12	10	15	as	as	IN
cord-260577-t4w4pw12	10	16	SARS	SARS	NNP
cord-260577-t4w4pw12	10	17	-	-	HYPH
cord-260577-t4w4pw12	10	18	mediated	mediate	VBN
cord-260577-t4w4pw12	10	19	lung	lung	NN
cord-260577-t4w4pw12	10	20	injury	injury	NN
cord-260577-t4w4pw12	10	21	.	.	.
cord-260577-t4w4pw12	11	1	We	-PRON-	PRP
cord-260577-t4w4pw12	11	2	review	review	VBP
cord-260577-t4w4pw12	11	3	the	the	DT
cord-260577-t4w4pw12	11	4	role	role	NN
cord-260577-t4w4pw12	11	5	of	of	IN
cord-260577-t4w4pw12	11	6	the	the	DT
cord-260577-t4w4pw12	11	7	RAS	RAS	NNP
cord-260577-t4w4pw12	11	8	,	,	,
cord-260577-t4w4pw12	11	9	in	in	IN
cord-260577-t4w4pw12	11	10	particular	particular	JJ
cord-260577-t4w4pw12	11	11	ACE2	ACE2	NNP
cord-260577-t4w4pw12	11	12	,	,	,
cord-260577-t4w4pw12	11	13	in	in	IN
cord-260577-t4w4pw12	11	14	the	the	DT
cord-260577-t4w4pw12	11	15	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	11	16	of	of	IN
cord-260577-t4w4pw12	11	17	ARDS	ARDS	NNP
cord-260577-t4w4pw12	11	18	.	.	.
cord-260577-t4w4pw12	12	1	Angiotensin	angiotensin	NN
cord-260577-t4w4pw12	12	2	-	-	HYPH
cord-260577-t4w4pw12	12	3	converting	convert	VBG
cord-260577-t4w4pw12	12	4	enzyme	enzyme	NN
cord-260577-t4w4pw12	12	5	(	(	-LRB-
cord-260577-t4w4pw12	12	6	ACE	ACE	NNP
cord-260577-t4w4pw12	12	7	)	)	-RRB-
cord-260577-t4w4pw12	12	8	and	and	CC
cord-260577-t4w4pw12	12	9	ACE2	ACE2	NNP
cord-260577-t4w4pw12	12	10	share	share	NN
cord-260577-t4w4pw12	12	11	homology	homology	NN
cord-260577-t4w4pw12	12	12	in	in	IN
cord-260577-t4w4pw12	12	13	their	-PRON-	PRP$
cord-260577-t4w4pw12	12	14	catalytic	catalytic	JJ
cord-260577-t4w4pw12	12	15	domain	domain	NN
cord-260577-t4w4pw12	12	16	and	and	CC
cord-260577-t4w4pw12	12	17	provide	provide	VB
cord-260577-t4w4pw12	12	18	different	different	JJ
cord-260577-t4w4pw12	12	19	key	key	JJ
cord-260577-t4w4pw12	12	20	functions	function	NNS
cord-260577-t4w4pw12	12	21	in	in	IN
cord-260577-t4w4pw12	12	22	the	the	DT
cord-260577-t4w4pw12	12	23	renin	renin	NN
cord-260577-t4w4pw12	12	24	-	-	HYPH
cord-260577-t4w4pw12	12	25	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	12	26	system	system	NN
cord-260577-t4w4pw12	12	27	(	(	-LRB-
cord-260577-t4w4pw12	12	28	RAS	RAS	NNP
cord-260577-t4w4pw12	12	29	)	)	-RRB-
cord-260577-t4w4pw12	12	30	.	.	.
cord-260577-t4w4pw12	13	1	ACE	ACE	NNP
cord-260577-t4w4pw12	13	2	cleaves	cleave	VBZ
cord-260577-t4w4pw12	14	1	angiotensin	angiotensin	NNP
cord-260577-t4w4pw12	15	1	I	-PRON-	PRP
cord-260577-t4w4pw12	15	2	(	(	-LRB-
cord-260577-t4w4pw12	15	3	Ang	Ang	NNP
cord-260577-t4w4pw12	15	4	I	i	NN
cord-260577-t4w4pw12	15	5	)	)	-RRB-
cord-260577-t4w4pw12	15	6	to	to	TO
cord-260577-t4w4pw12	15	7	generate	generate	VB
cord-260577-t4w4pw12	15	8	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	15	9	II	II	NNP
cord-260577-t4w4pw12	15	10	(	(	-LRB-
cord-260577-t4w4pw12	15	11	Ang	Ang	NNP
cord-260577-t4w4pw12	15	12	II	II	NNP
cord-260577-t4w4pw12	15	13	)	)	-RRB-
cord-260577-t4w4pw12	15	14	[	[	-LRB-
cord-260577-t4w4pw12	15	15	1	1	CD
cord-260577-t4w4pw12	15	16	,	,	,
cord-260577-t4w4pw12	15	17	2	2	CD
cord-260577-t4w4pw12	15	18	]	]	-RRB-
cord-260577-t4w4pw12	15	19	,	,	,
cord-260577-t4w4pw12	15	20	whereas	whereas	IN
cord-260577-t4w4pw12	15	21	ACE2	ACE2	NNP
cord-260577-t4w4pw12	15	22	reduces	reduce	VBZ
cord-260577-t4w4pw12	15	23	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	15	24	II	ii	CD
cord-260577-t4w4pw12	15	25	levels	level	NNS
cord-260577-t4w4pw12	15	26	[	[	-LRB-
cord-260577-t4w4pw12	15	27	3	3	CD
cord-260577-t4w4pw12	15	28	,	,	,
cord-260577-t4w4pw12	15	29	4	4	CD
cord-260577-t4w4pw12	15	30	]	]	-RRB-
cord-260577-t4w4pw12	15	31	and	and	CC
cord-260577-t4w4pw12	15	32	is	be	VBZ
cord-260577-t4w4pw12	15	33	a	a	DT
cord-260577-t4w4pw12	15	34	negative	negative	JJ
cord-260577-t4w4pw12	15	35	regulator	regulator	NN
cord-260577-t4w4pw12	15	36	of	of	IN
cord-260577-t4w4pw12	15	37	the	the	DT
cord-260577-t4w4pw12	15	38	system	system	NN
cord-260577-t4w4pw12	15	39	.	.	.
cord-260577-t4w4pw12	16	1	The	the	DT
cord-260577-t4w4pw12	16	2	importance	importance	NN
cord-260577-t4w4pw12	16	3	of	of	IN
cord-260577-t4w4pw12	16	4	the	the	DT
cord-260577-t4w4pw12	16	5	RAS	RAS	NNP
cord-260577-t4w4pw12	16	6	in	in	IN
cord-260577-t4w4pw12	16	7	acute	acute	JJ
cord-260577-t4w4pw12	16	8	respiratory	respiratory	JJ
cord-260577-t4w4pw12	16	9	distress	distress	NN
cord-260577-t4w4pw12	16	10	syndrome	syndrome	NN
cord-260577-t4w4pw12	16	11	(	(	-LRB-
cord-260577-t4w4pw12	16	12	ARDS	ARDS	NNP
cord-260577-t4w4pw12	16	13	)	)	-RRB-
cord-260577-t4w4pw12	16	14	has	have	VBZ
cord-260577-t4w4pw12	16	15	recently	recently	RB
cord-260577-t4w4pw12	16	16	re	re	VBN
cord-260577-t4w4pw12	16	17	-	-	VBN
cord-260577-t4w4pw12	16	18	emerged	emerge	VBN
cord-260577-t4w4pw12	16	19	owing	owe	VBG
cord-260577-t4w4pw12	16	20	to	to	IN
cord-260577-t4w4pw12	16	21	the	the	DT
cord-260577-t4w4pw12	16	22	identification	identification	NN
cord-260577-t4w4pw12	16	23	of	of	IN
cord-260577-t4w4pw12	16	24	ACE2	ACE2	NNP
cord-260577-t4w4pw12	16	25	as	as	IN
cord-260577-t4w4pw12	16	26	a	a	DT
cord-260577-t4w4pw12	16	27	receptor	receptor	NN
cord-260577-t4w4pw12	16	28	for	for	IN
cord-260577-t4w4pw12	16	29	the	the	DT
cord-260577-t4w4pw12	16	30	severe	severe	JJ
cord-260577-t4w4pw12	16	31	acute	acute	JJ
cord-260577-t4w4pw12	16	32	respiratory	respiratory	JJ
cord-260577-t4w4pw12	16	33	syndrome	syndrome	NN
cord-260577-t4w4pw12	16	34	-	-	HYPH
cord-260577-t4w4pw12	16	35	coronavirus	coronavirus	NN
cord-260577-t4w4pw12	16	36	(	(	-LRB-
cord-260577-t4w4pw12	16	37	SARS	SARS	NNP
cord-260577-t4w4pw12	16	38	-	-	HYPH
cord-260577-t4w4pw12	16	39	CoV	CoV	NNP
cord-260577-t4w4pw12	16	40	)	)	-RRB-
cord-260577-t4w4pw12	16	41	[	[	-LRB-
cord-260577-t4w4pw12	16	42	5	5	CD
cord-260577-t4w4pw12	16	43	]	]	-RRB-
cord-260577-t4w4pw12	16	44	.	.	.
cord-260577-t4w4pw12	17	1	In	in	IN
cord-260577-t4w4pw12	17	2	2003	2003	CD
cord-260577-t4w4pw12	17	3	,	,	,
cord-260577-t4w4pw12	17	4	SARS	SARS	NNP
cord-260577-t4w4pw12	17	5	spread	spread	VBD
cord-260577-t4w4pw12	17	6	throughout	throughout	IN
cord-260577-t4w4pw12	17	7	the	the	DT
cord-260577-t4w4pw12	17	8	world	world	NN
cord-260577-t4w4pw12	17	9	causing	cause	VBG
cord-260577-t4w4pw12	17	10	more	more	JJR
cord-260577-t4w4pw12	17	11	than	than	IN
cord-260577-t4w4pw12	17	12	800	800	CD
cord-260577-t4w4pw12	17	13	deaths	death	NNS
cord-260577-t4w4pw12	17	14	due	due	JJ
cord-260577-t4w4pw12	17	15	to	to	IN
cord-260577-t4w4pw12	17	16	ARDS	ARDS	NNP
cord-260577-t4w4pw12	17	17	[	[	-LRB-
cord-260577-t4w4pw12	17	18	6	6	CD
cord-260577-t4w4pw12	17	19	]	]	-RRB-
cord-260577-t4w4pw12	17	20	.	.	.
cord-260577-t4w4pw12	18	1	Our	-PRON-	PRP$
cord-260577-t4w4pw12	18	2	studies	study	NNS
cord-260577-t4w4pw12	18	3	demonstrated	demonstrate	VBD
cord-260577-t4w4pw12	18	4	that	that	IN
cord-260577-t4w4pw12	18	5	ACE2	ACE2	NNP
cord-260577-t4w4pw12	18	6	protects	protect	VBZ
cord-260577-t4w4pw12	18	7	mice	mouse	NNS
cord-260577-t4w4pw12	18	8	from	from	IN
cord-260577-t4w4pw12	18	9	acute	acute	JJ
cord-260577-t4w4pw12	18	10	lung	lung	NN
cord-260577-t4w4pw12	18	11	injury	injury	NN
cord-260577-t4w4pw12	18	12	[	[	-LRB-
cord-260577-t4w4pw12	18	13	7	7	CD
cord-260577-t4w4pw12	18	14	]	]	-RRB-
cord-260577-t4w4pw12	18	15	as	as	RB
cord-260577-t4w4pw12	18	16	well	well	RB
cord-260577-t4w4pw12	18	17	as	as	IN
cord-260577-t4w4pw12	18	18	SARS	SARS	NNP
cord-260577-t4w4pw12	18	19	-	-	HYPH
cord-260577-t4w4pw12	18	20	mediated	mediate	VBN
cord-260577-t4w4pw12	18	21	lung	lung	NN
cord-260577-t4w4pw12	18	22	injury	injury	NN
cord-260577-t4w4pw12	18	23	[	[	-LRB-
cord-260577-t4w4pw12	18	24	8	8	CD
cord-260577-t4w4pw12	18	25	]	]	-RRB-
cord-260577-t4w4pw12	18	26	.	.	.
cord-260577-t4w4pw12	19	1	In	in	IN
cord-260577-t4w4pw12	19	2	this	this	DT
cord-260577-t4w4pw12	19	3	article	article	NN
cord-260577-t4w4pw12	19	4	,	,	,
cord-260577-t4w4pw12	19	5	we	-PRON-	PRP
cord-260577-t4w4pw12	19	6	review	review	VBP
cord-260577-t4w4pw12	19	7	the	the	DT
cord-260577-t4w4pw12	19	8	role	role	NN
cord-260577-t4w4pw12	19	9	of	of	IN
cord-260577-t4w4pw12	19	10	the	the	DT
cord-260577-t4w4pw12	19	11	RAS	RAS	NNP
cord-260577-t4w4pw12	19	12	,	,	,
cord-260577-t4w4pw12	19	13	in	in	IN
cord-260577-t4w4pw12	19	14	particular	particular	JJ
cord-260577-t4w4pw12	19	15	ACE2	ACE2	NNP
cord-260577-t4w4pw12	19	16	,	,	,
cord-260577-t4w4pw12	19	17	in	in	IN
cord-260577-t4w4pw12	19	18	the	the	DT
cord-260577-t4w4pw12	19	19	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	19	20	of	of	IN
cord-260577-t4w4pw12	19	21	ARDS	ARDS	NNP
cord-260577-t4w4pw12	19	22	.	.	.
cord-260577-t4w4pw12	20	1	The	the	DT
cord-260577-t4w4pw12	20	2	possible	possible	JJ
cord-260577-t4w4pw12	20	3	applications	application	NNS
cord-260577-t4w4pw12	20	4	of	of	IN
cord-260577-t4w4pw12	20	5	modulating	modulate	VBG
cord-260577-t4w4pw12	20	6	the	the	DT
cord-260577-t4w4pw12	20	7	RAS	RAS	NNP
cord-260577-t4w4pw12	20	8	for	for	IN
cord-260577-t4w4pw12	20	9	the	the	DT
cord-260577-t4w4pw12	20	10	treatment	treatment	NN
cord-260577-t4w4pw12	20	11	of	of	IN
cord-260577-t4w4pw12	20	12	ARDS	ARDS	NNP
cord-260577-t4w4pw12	20	13	are	be	VBP
cord-260577-t4w4pw12	20	14	also	also	RB
cord-260577-t4w4pw12	20	15	discussed	discuss	VBN
cord-260577-t4w4pw12	20	16	.	.	.
cord-260577-t4w4pw12	21	1	ARDS	ARDS	NNP
cord-260577-t4w4pw12	21	2	is	be	VBZ
cord-260577-t4w4pw12	21	3	the	the	DT
cord-260577-t4w4pw12	21	4	most	most	RBS
cord-260577-t4w4pw12	21	5	severe	severe	JJ
cord-260577-t4w4pw12	21	6	form	form	NN
cord-260577-t4w4pw12	21	7	of	of	IN
cord-260577-t4w4pw12	21	8	acute	acute	JJ
cord-260577-t4w4pw12	21	9	lung	lung	NN
cord-260577-t4w4pw12	21	10	injury	injury	NN
cord-260577-t4w4pw12	21	11	.	.	.
cord-260577-t4w4pw12	22	1	Multiple	multiple	JJ
cord-260577-t4w4pw12	22	2	predisposing	predispose	VBG
cord-260577-t4w4pw12	22	3	factors	factor	NNS
cord-260577-t4w4pw12	22	4	for	for	IN
cord-260577-t4w4pw12	22	5	ARDS	ARDS	NNP
cord-260577-t4w4pw12	22	6	have	have	VBP
cord-260577-t4w4pw12	22	7	been	be	VBN
cord-260577-t4w4pw12	22	8	reported	report	VBN
cord-260577-t4w4pw12	22	9	and	and	CC
cord-260577-t4w4pw12	22	10	include	include	VBP
cord-260577-t4w4pw12	22	11	sepsis	sepsis	NN
cord-260577-t4w4pw12	22	12	,	,	,
cord-260577-t4w4pw12	22	13	acid	acid	JJ
cord-260577-t4w4pw12	22	14	aspiration	aspiration	NN
cord-260577-t4w4pw12	22	15	,	,	,
cord-260577-t4w4pw12	22	16	trauma	trauma	NN
cord-260577-t4w4pw12	22	17	or	or	CC
cord-260577-t4w4pw12	22	18	infections	infection	NNS
cord-260577-t4w4pw12	22	19	with	with	IN
cord-260577-t4w4pw12	22	20	viral	viral	JJ
cord-260577-t4w4pw12	22	21	pathogens	pathogen	NNS
cord-260577-t4w4pw12	22	22	such	such	JJ
cord-260577-t4w4pw12	22	23	as	as	IN
cord-260577-t4w4pw12	22	24	SARS	SARS	NNP
cord-260577-t4w4pw12	23	1	-CoV.	-cov.	ADD
cord-260577-t4w4pw12	24	1	Moreover	moreover	RB
cord-260577-t4w4pw12	24	2	,	,	,
cord-260577-t4w4pw12	24	3	very	very	RB
cord-260577-t4w4pw12	24	4	recently	recently	RB
cord-260577-t4w4pw12	24	5	H5N1	H5N1	NNP
cord-260577-t4w4pw12	24	6	avian	avian	JJ
cord-260577-t4w4pw12	24	7	influenza	influenza	NN
cord-260577-t4w4pw12	24	8	virus	virus	NN
cord-260577-t4w4pw12	24	9	has	have	VBZ
cord-260577-t4w4pw12	24	10	caused	cause	VBN
cord-260577-t4w4pw12	24	11	high	high	JJ
cord-260577-t4w4pw12	24	12	lethality	lethality	NN
cord-260577-t4w4pw12	24	13	due	due	IN
cord-260577-t4w4pw12	24	14	to	to	IN
cord-260577-t4w4pw12	24	15	ARDS	ARDS	NNP
cord-260577-t4w4pw12	24	16	[	[	-LRB-
cord-260577-t4w4pw12	24	17	9	9	CD
cord-260577-t4w4pw12	24	18	]	]	-RRB-
cord-260577-t4w4pw12	24	19	.	.	.
cord-260577-t4w4pw12	25	1	Despite	despite	IN
cord-260577-t4w4pw12	25	2	recent	recent	JJ
cord-260577-t4w4pw12	25	3	progress	progress	NN
cord-260577-t4w4pw12	25	4	,	,	,
cord-260577-t4w4pw12	25	5	the	the	DT
cord-260577-t4w4pw12	25	6	mortality	mortality	NN
cord-260577-t4w4pw12	25	7	associated	associate	VBN
cord-260577-t4w4pw12	25	8	with	with	IN
cord-260577-t4w4pw12	25	9	ARDS	ARDS	NNP
cord-260577-t4w4pw12	25	10	remains	remain	VBZ
cord-260577-t4w4pw12	25	11	very	very	RB
cord-260577-t4w4pw12	25	12	high	high	JJ
cord-260577-t4w4pw12	25	13	,	,	,
cord-260577-t4w4pw12	25	14	and	and	CC
cord-260577-t4w4pw12	25	15	there	there	EX
cord-260577-t4w4pw12	25	16	is	be	VBZ
cord-260577-t4w4pw12	25	17	no	no	DT
cord-260577-t4w4pw12	25	18	pharmacological	pharmacological	JJ
cord-260577-t4w4pw12	25	19	therapy	therapy	NN
cord-260577-t4w4pw12	25	20	that	that	WDT
cord-260577-t4w4pw12	25	21	has	have	VBZ
cord-260577-t4w4pw12	25	22	been	be	VBN
cord-260577-t4w4pw12	25	23	shown	show	VBN
cord-260577-t4w4pw12	25	24	in	in	IN
cord-260577-t4w4pw12	25	25	large	large	JJ
cord-260577-t4w4pw12	25	26	-	-	HYPH
cord-260577-t4w4pw12	25	27	scale	scale	NN
cord-260577-t4w4pw12	25	28	trials	trial	NNS
cord-260577-t4w4pw12	25	29	to	to	TO
cord-260577-t4w4pw12	25	30	impact	impact	VB
cord-260577-t4w4pw12	25	31	mortality	mortality	NN
cord-260577-t4w4pw12	25	32	in	in	IN
cord-260577-t4w4pw12	25	33	ARDS	ARDS	NNP
cord-260577-t4w4pw12	25	34	[	[	-LRB-
cord-260577-t4w4pw12	25	35	10	10	CD
cord-260577-t4w4pw12	25	36	]	]	-RRB-
cord-260577-t4w4pw12	25	37	.	.	.
cord-260577-t4w4pw12	26	1	Factors	factor	NNS
cord-260577-t4w4pw12	26	2	predicting	predict	VBG
cord-260577-t4w4pw12	26	3	the	the	DT
cord-260577-t4w4pw12	26	4	onset	onset	NN
cord-260577-t4w4pw12	26	5	or	or	CC
cord-260577-t4w4pw12	26	6	severity	severity	NN
cord-260577-t4w4pw12	26	7	of	of	IN
cord-260577-t4w4pw12	26	8	ARDS	ARDS	NNP
cord-260577-t4w4pw12	26	9	are	be	VBP
cord-260577-t4w4pw12	26	10	poorly	poorly	RB
cord-260577-t4w4pw12	26	11	understood	understand	VBN
cord-260577-t4w4pw12	26	12	,	,	,
cord-260577-t4w4pw12	26	13	but	but	CC
cord-260577-t4w4pw12	26	14	the	the	DT
cord-260577-t4w4pw12	26	15	low	low	JJ
cord-260577-t4w4pw12	26	16	incidence	incidence	NN
cord-260577-t4w4pw12	26	17	of	of	IN
cord-260577-t4w4pw12	26	18	ARDS	ARDS	NNP
cord-260577-t4w4pw12	26	19	in	in	IN
cord-260577-t4w4pw12	26	20	the	the	DT
cord-260577-t4w4pw12	26	21	relatively	relatively	RB
cord-260577-t4w4pw12	26	22	large	large	JJ
cord-260577-t4w4pw12	26	23	group	group	NN
cord-260577-t4w4pw12	26	24	of	of	IN
cord-260577-t4w4pw12	26	25	patients	patient	NNS
cord-260577-t4w4pw12	26	26	at	at	IN
cord-260577-t4w4pw12	26	27	risk	risk	NN
cord-260577-t4w4pw12	26	28	has	have	VBZ
cord-260577-t4w4pw12	26	29	been	be	VBN
cord-260577-t4w4pw12	26	30	shown	show	VBN
cord-260577-t4w4pw12	26	31	.	.	.
cord-260577-t4w4pw12	27	1	Also	also	RB
cord-260577-t4w4pw12	27	2	,	,	,
cord-260577-t4w4pw12	27	3	there	there	EX
cord-260577-t4w4pw12	27	4	are	be	VBP
cord-260577-t4w4pw12	27	5	large	large	JJ
cord-260577-t4w4pw12	27	6	differences	difference	NNS
cord-260577-t4w4pw12	27	7	in	in	IN
cord-260577-t4w4pw12	27	8	plasma	plasma	NN
cord-260577-t4w4pw12	27	9	ACE	ace	NN
cord-260577-t4w4pw12	27	10	concentrations	concentration	NNS
cord-260577-t4w4pw12	27	11	between	between	IN
cord-260577-t4w4pw12	27	12	individuals	individual	NNS
cord-260577-t4w4pw12	27	13	but	but	CC
cord-260577-t4w4pw12	27	14	such	such	JJ
cord-260577-t4w4pw12	27	15	concentrations	concentration	NNS
cord-260577-t4w4pw12	27	16	tend	tend	VBP
cord-260577-t4w4pw12	27	17	to	to	TO
cord-260577-t4w4pw12	27	18	be	be	VB
cord-260577-t4w4pw12	27	19	similar	similar	JJ
cord-260577-t4w4pw12	27	20	within	within	IN
cord-260577-t4w4pw12	27	21	families	family	NNS
cord-260577-t4w4pw12	27	22	[	[	-LRB-
cord-260577-t4w4pw12	27	23	11	11	CD
cord-260577-t4w4pw12	27	24	]	]	-RRB-
cord-260577-t4w4pw12	27	25	.	.	.
cord-260577-t4w4pw12	28	1	These	these	DT
cord-260577-t4w4pw12	28	2	suggest	suggest	VBP
cord-260577-t4w4pw12	28	3	the	the	DT
cord-260577-t4w4pw12	28	4	involvement	involvement	NN
cord-260577-t4w4pw12	28	5	of	of	IN
cord-260577-t4w4pw12	28	6	genetic	genetic	JJ
cord-260577-t4w4pw12	28	7	components	component	NNS
cord-260577-t4w4pw12	28	8	in	in	IN
cord-260577-t4w4pw12	28	9	the	the	DT
cord-260577-t4w4pw12	28	10	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	28	11	of	of	IN
cord-260577-t4w4pw12	28	12	ARDS	ARDS	NNP
cord-260577-t4w4pw12	28	13	.	.	.
cord-260577-t4w4pw12	29	1	The	the	DT
cord-260577-t4w4pw12	29	2	human	human	JJ
cord-260577-t4w4pw12	29	3	ACE	ace	NN
cord-260577-t4w4pw12	29	4	gene	gene	NN
cord-260577-t4w4pw12	29	5	(	(	-LRB-
cord-260577-t4w4pw12	29	6	dcp1	dcp1	NNP
cord-260577-t4w4pw12	29	7	)	)	-RRB-
cord-260577-t4w4pw12	29	8	is	be	VBZ
cord-260577-t4w4pw12	29	9	located	locate	VBN
cord-260577-t4w4pw12	29	10	on	on	IN
cord-260577-t4w4pw12	29	11	chromosome	chromosome	NN
cord-260577-t4w4pw12	29	12	17q23	17q23	CD
cord-260577-t4w4pw12	29	13	and	and	CC
cord-260577-t4w4pw12	29	14	contains	contain	VBZ
cord-260577-t4w4pw12	29	15	a	a	DT
cord-260577-t4w4pw12	29	16	restriction	restriction	NN
cord-260577-t4w4pw12	29	17	fragment	fragment	NN
cord-260577-t4w4pw12	29	18	length	length	NN
cord-260577-t4w4pw12	29	19	polymorphism	polymorphism	NN
cord-260577-t4w4pw12	29	20	defined	define	VBN
cord-260577-t4w4pw12	29	21	by	by	IN
cord-260577-t4w4pw12	29	22	the	the	DT
cord-260577-t4w4pw12	29	23	presence	presence	NN
cord-260577-t4w4pw12	29	24	(	(	-LRB-
cord-260577-t4w4pw12	29	25	insertion	insertion	NN
cord-260577-t4w4pw12	29	26	,	,	,
cord-260577-t4w4pw12	29	27	I	-PRON-	PRP
cord-260577-t4w4pw12	29	28	)	)	-RRB-
cord-260577-t4w4pw12	29	29	or	or	CC
cord-260577-t4w4pw12	29	30	absence	absence	NN
cord-260577-t4w4pw12	29	31	(	(	-LRB-
cord-260577-t4w4pw12	29	32	deletion	deletion	NN
cord-260577-t4w4pw12	29	33	,	,	,
cord-260577-t4w4pw12	29	34	D	D	NNP
cord-260577-t4w4pw12	29	35	)	)	-RRB-
cord-260577-t4w4pw12	29	36	of	of	IN
cord-260577-t4w4pw12	29	37	a	a	DT
cord-260577-t4w4pw12	29	38	287-bp	287-bp	CD
cord-260577-t4w4pw12	29	39	alu	alu	NN
cord-260577-t4w4pw12	29	40	repeat	repeat	NN
cord-260577-t4w4pw12	29	41	sequence	sequence	NN
cord-260577-t4w4pw12	29	42	in	in	IN
cord-260577-t4w4pw12	29	43	intron	intron	NN
cord-260577-t4w4pw12	29	44	16	16	CD
cord-260577-t4w4pw12	29	45	.	.	.
cord-260577-t4w4pw12	30	1	Nearly	nearly	RB
cord-260577-t4w4pw12	30	2	50	50	CD
cord-260577-t4w4pw12	30	3	%	%	NN
cord-260577-t4w4pw12	30	4	of	of	IN
cord-260577-t4w4pw12	30	5	the	the	DT
cord-260577-t4w4pw12	30	6	variance	variance	NN
cord-260577-t4w4pw12	30	7	in	in	IN
cord-260577-t4w4pw12	30	8	plasma	plasma	NN
cord-260577-t4w4pw12	30	9	ACE	ace	NN
cord-260577-t4w4pw12	30	10	activity	activity	NN
cord-260577-t4w4pw12	30	11	can	can	MD
cord-260577-t4w4pw12	30	12	be	be	VB
cord-260577-t4w4pw12	30	13	accounted	account	VBN
cord-260577-t4w4pw12	30	14	for	for	IN
cord-260577-t4w4pw12	30	15	by	by	IN
cord-260577-t4w4pw12	30	16	this	this	DT
cord-260577-t4w4pw12	30	17	ACE	ace	NN
cord-260577-t4w4pw12	30	18	insertion	insertion	NN
cord-260577-t4w4pw12	30	19	/	/	SYM
cord-260577-t4w4pw12	30	20	deletion	deletion	NN
cord-260577-t4w4pw12	30	21	(	(	-LRB-
cord-260577-t4w4pw12	30	22	I	i	NN
cord-260577-t4w4pw12	30	23	/	/	SYM
cord-260577-t4w4pw12	30	24	D	d	NN
cord-260577-t4w4pw12	30	25	)	)	-RRB-
cord-260577-t4w4pw12	30	26	polymorphism	polymorphism	NN
cord-260577-t4w4pw12	30	27	,	,	,
cord-260577-t4w4pw12	30	28	the	the	DT
cord-260577-t4w4pw12	30	29	D	d	NN
cord-260577-t4w4pw12	30	30	allele	allele	NN
cord-260577-t4w4pw12	30	31	being	be	VBG
cord-260577-t4w4pw12	30	32	associated	associate	VBN
cord-260577-t4w4pw12	30	33	with	with	IN
cord-260577-t4w4pw12	30	34	higher	high	JJR
cord-260577-t4w4pw12	30	35	ACE	ace	NN
cord-260577-t4w4pw12	30	36	activity	activity	NN
cord-260577-t4w4pw12	30	37	[	[	-LRB-
cord-260577-t4w4pw12	30	38	12	12	CD
cord-260577-t4w4pw12	30	39	]	]	-RRB-
cord-260577-t4w4pw12	30	40	.	.	.
cord-260577-t4w4pw12	31	1	Importantly	importantly	RB
cord-260577-t4w4pw12	31	2	,	,	,
cord-260577-t4w4pw12	31	3	recent	recent	JJ
cord-260577-t4w4pw12	31	4	cohort	cohort	NN
cord-260577-t4w4pw12	31	5	studies	study	NNS
cord-260577-t4w4pw12	31	6	of	of	IN
cord-260577-t4w4pw12	31	7	ARDS	ARDS	NNP
cord-260577-t4w4pw12	31	8	showed	show	VBD
cord-260577-t4w4pw12	31	9	a	a	DT
cord-260577-t4w4pw12	31	10	significant	significant	JJ
cord-260577-t4w4pw12	31	11	association	association	NN
cord-260577-t4w4pw12	31	12	between	between	IN
cord-260577-t4w4pw12	31	13	an	an	DT
cord-260577-t4w4pw12	31	14	ACE	ace	NN
cord-260577-t4w4pw12	31	15	I	I	NNP
cord-260577-t4w4pw12	31	16	/	/	SYM
cord-260577-t4w4pw12	31	17	D	d	NN
cord-260577-t4w4pw12	31	18	polymorphism	polymorphism	NN
cord-260577-t4w4pw12	31	19	and	and	CC
cord-260577-t4w4pw12	31	20	the	the	DT
cord-260577-t4w4pw12	31	21	susceptibility	susceptibility	NN
cord-260577-t4w4pw12	31	22	and	and	CC
cord-260577-t4w4pw12	31	23	mortality	mortality	NN
cord-260577-t4w4pw12	31	24	of	of	IN
cord-260577-t4w4pw12	31	25	ARDS	ARDS	NNP
cord-260577-t4w4pw12	31	26	[	[	-LRB-
cord-260577-t4w4pw12	31	27	13	13	CD
cord-260577-t4w4pw12	31	28	]	]	-RRB-
cord-260577-t4w4pw12	31	29	.	.	.
cord-260577-t4w4pw12	32	1	The	the	DT
cord-260577-t4w4pw12	32	2	D	d	NN
cord-260577-t4w4pw12	32	3	/	/	SYM
cord-260577-t4w4pw12	32	4	D	d	NN
cord-260577-t4w4pw12	32	5	genotype	genotype	NN
cord-260577-t4w4pw12	32	6	frequency	frequency	NN
cord-260577-t4w4pw12	32	7	was	be	VBD
cord-260577-t4w4pw12	32	8	increased	increase	VBN
cord-260577-t4w4pw12	32	9	in	in	IN
cord-260577-t4w4pw12	32	10	patients	patient	NNS
cord-260577-t4w4pw12	32	11	with	with	IN
cord-260577-t4w4pw12	32	12	ARDS	ARDS	NNP
cord-260577-t4w4pw12	32	13	compared	compare	VBN
cord-260577-t4w4pw12	32	14	with	with	IN
cord-260577-t4w4pw12	32	15	the	the	DT
cord-260577-t4w4pw12	32	16	control	control	NN
cord-260577-t4w4pw12	32	17	cohort	cohort	NN
cord-260577-t4w4pw12	32	18	.	.	.
cord-260577-t4w4pw12	33	1	Ninety	ninety	CD
cord-260577-t4w4pw12	33	2	-	-	HYPH
cord-260577-t4w4pw12	33	3	six	six	CD
cord-260577-t4w4pw12	33	4	patients	patient	NNS
cord-260577-t4w4pw12	33	5	fulfilling	fulfil	VBG
cord-260577-t4w4pw12	33	6	the	the	DT
cord-260577-t4w4pw12	33	7	criteria	criterion	NNS
cord-260577-t4w4pw12	33	8	for	for	IN
cord-260577-t4w4pw12	33	9	ARDS	ARDS	NNP
cord-260577-t4w4pw12	33	10	were	be	VBD
cord-260577-t4w4pw12	33	11	genotyped	genotype	VBN
cord-260577-t4w4pw12	33	12	for	for	IN
cord-260577-t4w4pw12	33	13	the	the	DT
cord-260577-t4w4pw12	33	14	ACE	ace	NN
cord-260577-t4w4pw12	33	15	polymorphism	polymorphism	NN
cord-260577-t4w4pw12	33	16	together	together	RB
cord-260577-t4w4pw12	33	17	with	with	IN
cord-260577-t4w4pw12	33	18	individuals	individual	NNS
cord-260577-t4w4pw12	33	19	from	from	IN
cord-260577-t4w4pw12	33	20	three	three	CD
cord-260577-t4w4pw12	33	21	comparison	comparison	NN
cord-260577-t4w4pw12	33	22	groups	group	NNS
cord-260577-t4w4pw12	33	23	:	:	:
cord-260577-t4w4pw12	33	24	88	88	CD
cord-260577-t4w4pw12	33	25	patients	patient	NNS
cord-260577-t4w4pw12	33	26	with	with	IN
cord-260577-t4w4pw12	33	27	non	non	JJ
cord-260577-t4w4pw12	33	28	-	-	JJ
cord-260577-t4w4pw12	33	29	ARDS	ards	JJ
cord-260577-t4w4pw12	33	30	respiratory	respiratory	JJ
cord-260577-t4w4pw12	33	31	failure	failure	NN
cord-260577-t4w4pw12	33	32	ventilated	ventilate	VBN
cord-260577-t4w4pw12	33	33	in	in	IN
cord-260577-t4w4pw12	33	34	the	the	DT
cord-260577-t4w4pw12	33	35	Intensive	Intensive	NNP
cord-260577-t4w4pw12	33	36	Care	Care	NNP
cord-260577-t4w4pw12	33	37	Unit	Unit	NNP
cord-260577-t4w4pw12	33	38	(	(	-LRB-
cord-260577-t4w4pw12	33	39	ICU	ICU	NNP
cord-260577-t4w4pw12	33	40	)	)	-RRB-
cord-260577-t4w4pw12	33	41	,	,	,
cord-260577-t4w4pw12	33	42	174	174	CD
cord-260577-t4w4pw12	33	43	ICU	ICU	NNP
cord-260577-t4w4pw12	33	44	patients	patient	NNS
cord-260577-t4w4pw12	33	45	undergoing	undergo	VBG
cord-260577-t4w4pw12	33	46	coronary	coronary	JJ
cord-260577-t4w4pw12	33	47	artery	artery	NN
cord-260577-t4w4pw12	33	48	bypass	bypass	NN
cord-260577-t4w4pw12	33	49	grafting	grafting	NN
cord-260577-t4w4pw12	33	50	and	and	CC
cord-260577-t4w4pw12	33	51	1906	1906	CD
cord-260577-t4w4pw12	33	52	individuals	individual	NNS
cord-260577-t4w4pw12	33	53	from	from	IN
cord-260577-t4w4pw12	33	54	a	a	DT
cord-260577-t4w4pw12	33	55	general	general	JJ
cord-260577-t4w4pw12	33	56	population	population	NN
cord-260577-t4w4pw12	33	57	group	group	NN
cord-260577-t4w4pw12	33	58	.	.	.
cord-260577-t4w4pw12	34	1	DD	DD	NNP
cord-260577-t4w4pw12	34	2	genotype	genotype	NN
cord-260577-t4w4pw12	34	3	frequency	frequency	NN
cord-260577-t4w4pw12	34	4	was	be	VBD
cord-260577-t4w4pw12	34	5	increased	increase	VBN
cord-260577-t4w4pw12	34	6	in	in	IN
cord-260577-t4w4pw12	34	7	the	the	DT
cord-260577-t4w4pw12	34	8	patients	patient	NNS
cord-260577-t4w4pw12	34	9	with	with	IN
cord-260577-t4w4pw12	34	10	ARDS	ARDS	NNP
cord-260577-t4w4pw12	34	11	compared	compare	VBN
cord-260577-t4w4pw12	34	12	with	with	IN
cord-260577-t4w4pw12	34	13	the	the	DT
cord-260577-t4w4pw12	34	14	ICU	ICU	NNP
cord-260577-t4w4pw12	34	15	(	(	-LRB-
cord-260577-t4w4pw12	34	16	P	p	NN
cord-260577-t4w4pw12	34	17	=	=	SYM
cord-260577-t4w4pw12	34	18	0.00008	0.00008	CD
cord-260577-t4w4pw12	34	19	)	)	-RRB-
cord-260577-t4w4pw12	34	20	,	,	,
cord-260577-t4w4pw12	34	21	coronary	coronary	JJ
cord-260577-t4w4pw12	34	22	artery	artery	NN
cord-260577-t4w4pw12	34	23	bypass	bypass	NN
cord-260577-t4w4pw12	34	24	grafting	grafting	NN
cord-260577-t4w4pw12	34	25	(	(	-LRB-
cord-260577-t4w4pw12	34	26	P	p	NN
cord-260577-t4w4pw12	34	27	=	=	SYM
cord-260577-t4w4pw12	34	28	0.0009	0.0009	CD
cord-260577-t4w4pw12	34	29	)	)	-RRB-
cord-260577-t4w4pw12	34	30	and	and	CC
cord-260577-t4w4pw12	34	31	the	the	DT
cord-260577-t4w4pw12	34	32	general	general	JJ
cord-260577-t4w4pw12	34	33	population	population	NN
cord-260577-t4w4pw12	34	34	group	group	NN
cord-260577-t4w4pw12	34	35	(	(	-LRB-
cord-260577-t4w4pw12	34	36	P	p	NN
cord-260577-t4w4pw12	34	37	=	=	SYM
cord-260577-t4w4pw12	34	38	0.00004	0.00004	CD
cord-260577-t4w4pw12	34	39	)	)	-RRB-
cord-260577-t4w4pw12	34	40	.	.	.
cord-260577-t4w4pw12	35	1	In	in	IN
cord-260577-t4w4pw12	35	2	addition	addition	NN
cord-260577-t4w4pw12	35	3	,	,	,
cord-260577-t4w4pw12	35	4	the	the	DT
cord-260577-t4w4pw12	35	5	ACE	ace	NN
cord-260577-t4w4pw12	35	6	D	D	NNP
cord-260577-t4w4pw12	35	7	/	/	SYM
cord-260577-t4w4pw12	35	8	D	d	NN
cord-260577-t4w4pw12	35	9	allele	allele	NN
cord-260577-t4w4pw12	35	10	significantly	significantly	RB
cord-260577-t4w4pw12	35	11	correlated	correlate	VBD
cord-260577-t4w4pw12	35	12	with	with	IN
cord-260577-t4w4pw12	35	13	mortality	mortality	NN
cord-260577-t4w4pw12	35	14	in	in	IN
cord-260577-t4w4pw12	35	15	the	the	DT
cord-260577-t4w4pw12	35	16	ARDS	ARDS	NNP
cord-260577-t4w4pw12	35	17	group	group	NN
cord-260577-t4w4pw12	35	18	.	.	.
cord-260577-t4w4pw12	36	1	Another	another	DT
cord-260577-t4w4pw12	36	2	study	study	NN
cord-260577-t4w4pw12	36	3	showed	show	VBD
cord-260577-t4w4pw12	36	4	that	that	IN
cord-260577-t4w4pw12	36	5	patients	patient	NNS
cord-260577-t4w4pw12	36	6	carrying	carry	VBG
cord-260577-t4w4pw12	36	7	the	the	DT
cord-260577-t4w4pw12	36	8	ACE	ace	NN
cord-260577-t4w4pw12	37	1	I/	I/	NNP
cord-260577-t4w4pw12	38	1	I	-PRON-	PRP
cord-260577-t4w4pw12	38	2	genotype	genotype	NN
cord-260577-t4w4pw12	38	3	have	have	VBP
cord-260577-t4w4pw12	38	4	a	a	DT
cord-260577-t4w4pw12	38	5	significantly	significantly	RB
cord-260577-t4w4pw12	38	6	increased	increase	VBN
cord-260577-t4w4pw12	38	7	survival	survival	NN
cord-260577-t4w4pw12	38	8	rate	rate	NN
cord-260577-t4w4pw12	38	9	[	[	-LRB-
cord-260577-t4w4pw12	38	10	14	14	CD
cord-260577-t4w4pw12	38	11	]	]	-RRB-
cord-260577-t4w4pw12	38	12	.	.	.
cord-260577-t4w4pw12	39	1	In	in	IN
cord-260577-t4w4pw12	39	2	that	that	DT
cord-260577-t4w4pw12	39	3	study	study	NN
cord-260577-t4w4pw12	39	4	,	,	,
cord-260577-t4w4pw12	39	5	the	the	DT
cord-260577-t4w4pw12	39	6	28-day	28-day	CD
cord-260577-t4w4pw12	39	7	mortality	mortality	NN
cord-260577-t4w4pw12	39	8	rates	rate	NNS
cord-260577-t4w4pw12	39	9	were	be	VBD
cord-260577-t4w4pw12	39	10	significantly	significantly	RB
cord-260577-t4w4pw12	39	11	different	different	JJ
cord-260577-t4w4pw12	39	12	in	in	IN
cord-260577-t4w4pw12	39	13	the	the	DT
cord-260577-t4w4pw12	39	14	three	three	CD
cord-260577-t4w4pw12	39	15	ACE	ace	NN
cord-260577-t4w4pw12	39	16	genotypes	genotype	NNS
cord-260577-t4w4pw12	39	17	(	(	-LRB-
cord-260577-t4w4pw12	39	18	42	42	CD
cord-260577-t4w4pw12	39	19	%	%	NN
cord-260577-t4w4pw12	39	20	,	,	,
cord-260577-t4w4pw12	39	21	65	65	CD
cord-260577-t4w4pw12	39	22	%	%	NN
cord-260577-t4w4pw12	39	23	and	and	CC
cord-260577-t4w4pw12	39	24	75	75	CD
cord-260577-t4w4pw12	39	25	%	%	NN
cord-260577-t4w4pw12	39	26	for	for	IN
cord-260577-t4w4pw12	39	27	I	I	NNP
cord-260577-t4w4pw12	39	28	/	/	,
cord-260577-t4w4pw12	39	29	I	-PRON-	PRP
cord-260577-t4w4pw12	39	30	,	,	,
cord-260577-t4w4pw12	39	31	I	I	NNP
cord-260577-t4w4pw12	39	32	/	/	SYM
cord-260577-t4w4pw12	39	33	D	D	NNP
cord-260577-t4w4pw12	39	34	and	and	CC
cord-260577-t4w4pw12	39	35	D	D	NNP
cord-260577-t4w4pw12	39	36	/	/	SYM
cord-260577-t4w4pw12	39	37	D	d	NN
cord-260577-t4w4pw12	39	38	,	,	,
cord-260577-t4w4pw12	39	39	respectively	respectively	RB
cord-260577-t4w4pw12	39	40	;	;	:
cord-260577-t4w4pw12	39	41	P	p	NN
cord-260577-t4w4pw12	39	42	=	=	SYM
cord-260577-t4w4pw12	39	43	0.036	0.036	CD
cord-260577-t4w4pw12	39	44	)	)	-RRB-
cord-260577-t4w4pw12	39	45	in	in	IN
cord-260577-t4w4pw12	39	46	the	the	DT
cord-260577-t4w4pw12	39	47	ARDS	ARDS	NNP
cord-260577-t4w4pw12	39	48	group	group	NN
cord-260577-t4w4pw12	39	49	.	.	.
cord-260577-t4w4pw12	40	1	Taken	take	VBN
cord-260577-t4w4pw12	40	2	together	together	RB
cord-260577-t4w4pw12	40	3	,	,	,
cord-260577-t4w4pw12	40	4	these	these	DT
cord-260577-t4w4pw12	40	5	data	datum	NNS
cord-260577-t4w4pw12	40	6	suggest	suggest	VBP
cord-260577-t4w4pw12	40	7	a	a	DT
cord-260577-t4w4pw12	40	8	potential	potential	JJ
cord-260577-t4w4pw12	40	9	role	role	NN
cord-260577-t4w4pw12	40	10	for	for	IN
cord-260577-t4w4pw12	40	11	RAS	RAS	NNP
cord-260577-t4w4pw12	40	12	in	in	IN
cord-260577-t4w4pw12	40	13	the	the	DT
cord-260577-t4w4pw12	40	14	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	40	15	of	of	IN
cord-260577-t4w4pw12	40	16	ARDS	ARDS	NNP
cord-260577-t4w4pw12	40	17	and	and	CC
cord-260577-t4w4pw12	40	18	implicate	implicate	VB
cord-260577-t4w4pw12	40	19	genetic	genetic	JJ
cord-260577-t4w4pw12	40	20	factors	factor	NNS
cord-260577-t4w4pw12	40	21	in	in	IN
cord-260577-t4w4pw12	40	22	susceptibility	susceptibility	NN
cord-260577-t4w4pw12	40	23	and	and	CC
cord-260577-t4w4pw12	40	24	progression	progression	NN
cord-260577-t4w4pw12	40	25	of	of	IN
cord-260577-t4w4pw12	40	26	this	this	DT
cord-260577-t4w4pw12	40	27	syndrome	syndrome	NN
cord-260577-t4w4pw12	40	28	.	.	.
cord-260577-t4w4pw12	41	1	In	in	IN
cord-260577-t4w4pw12	41	2	addition	addition	NN
cord-260577-t4w4pw12	41	3	to	to	IN
cord-260577-t4w4pw12	41	4	genetic	genetic	JJ
cord-260577-t4w4pw12	41	5	correlation	correlation	NN
cord-260577-t4w4pw12	41	6	studies	study	NNS
cord-260577-t4w4pw12	41	7	,	,	,
cord-260577-t4w4pw12	41	8	substantial	substantial	JJ
cord-260577-t4w4pw12	41	9	clinical	clinical	JJ
cord-260577-t4w4pw12	41	10	studies	study	NNS
cord-260577-t4w4pw12	41	11	suggest	suggest	VBP
cord-260577-t4w4pw12	41	12	the	the	DT
cord-260577-t4w4pw12	41	13	possible	possible	JJ
cord-260577-t4w4pw12	41	14	activation	activation	NN
cord-260577-t4w4pw12	41	15	of	of	IN
cord-260577-t4w4pw12	41	16	RAS	RAS	NNP
cord-260577-t4w4pw12	41	17	in	in	IN
cord-260577-t4w4pw12	41	18	patients	patient	NNS
cord-260577-t4w4pw12	41	19	with	with	IN
cord-260577-t4w4pw12	41	20	ARDS	ARDS	NNP
cord-260577-t4w4pw12	41	21	.	.	.
cord-260577-t4w4pw12	42	1	For	for	IN
cord-260577-t4w4pw12	42	2	instance	instance	NN
cord-260577-t4w4pw12	42	3	,	,	,
cord-260577-t4w4pw12	42	4	in	in	IN
cord-260577-t4w4pw12	42	5	patients	patient	NNS
cord-260577-t4w4pw12	42	6	with	with	IN
cord-260577-t4w4pw12	42	7	ARDS	ARDS	NNP
cord-260577-t4w4pw12	42	8	,	,	,
cord-260577-t4w4pw12	42	9	an	an	DT
cord-260577-t4w4pw12	42	10	elevation	elevation	NN
cord-260577-t4w4pw12	42	11	of	of	IN
cord-260577-t4w4pw12	42	12	ACE	ace	NN
cord-260577-t4w4pw12	42	13	levels	level	NNS
cord-260577-t4w4pw12	42	14	in	in	IN
cord-260577-t4w4pw12	42	15	bronchoalveolar	bronchoalveolar	NNP
cord-260577-t4w4pw12	42	16	lavage	lavage	NN
cord-260577-t4w4pw12	42	17	fluid	fluid	NN
cord-260577-t4w4pw12	42	18	has	have	VBZ
cord-260577-t4w4pw12	42	19	been	be	VBN
cord-260577-t4w4pw12	42	20	observed	observe	VBN
cord-260577-t4w4pw12	42	21	despite	despite	IN
cord-260577-t4w4pw12	42	22	a	a	DT
cord-260577-t4w4pw12	42	23	reduction	reduction	NN
cord-260577-t4w4pw12	42	24	in	in	IN
cord-260577-t4w4pw12	42	25	circulating	circulate	VBG
cord-260577-t4w4pw12	42	26	ACE	ace	NN
cord-260577-t4w4pw12	42	27	[	[	-LRB-
cord-260577-t4w4pw12	42	28	15	15	CD
cord-260577-t4w4pw12	42	29	]	]	-RRB-
cord-260577-t4w4pw12	42	30	.	.	.
cord-260577-t4w4pw12	43	1	Reduced	reduce	VBN
cord-260577-t4w4pw12	43	2	circulating	circulate	VBG
cord-260577-t4w4pw12	43	3	ACE	ace	NN
cord-260577-t4w4pw12	43	4	levels	level	NNS
cord-260577-t4w4pw12	43	5	may	may	MD
cord-260577-t4w4pw12	43	6	reflect	reflect	VB
cord-260577-t4w4pw12	43	7	loss	loss	NN
cord-260577-t4w4pw12	43	8	of	of	IN
cord-260577-t4w4pw12	43	9	enzyme	enzyme	NN
cord-260577-t4w4pw12	43	10	release	release	NN
cord-260577-t4w4pw12	43	11	from	from	IN
cord-260577-t4w4pw12	43	12	a	a	DT
cord-260577-t4w4pw12	43	13	damaged	damage	VBN
cord-260577-t4w4pw12	43	14	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	43	15	vascular	vascular	JJ
cord-260577-t4w4pw12	43	16	endothelium	endothelium	NN
cord-260577-t4w4pw12	43	17	and	and	CC
cord-260577-t4w4pw12	43	18	may	may	MD
cord-260577-t4w4pw12	43	19	not	not	RB
cord-260577-t4w4pw12	43	20	be	be	VB
cord-260577-t4w4pw12	43	21	representative	representative	NN
cord-260577-t4w4pw12	43	22	of	of	IN
cord-260577-t4w4pw12	43	23	activity	activity	NN
cord-260577-t4w4pw12	43	24	in	in	IN
cord-260577-t4w4pw12	43	25	the	the	DT
cord-260577-t4w4pw12	43	26	lung	lung	NN
cord-260577-t4w4pw12	43	27	compartment	compartment	NN
cord-260577-t4w4pw12	43	28	.	.	.
cord-260577-t4w4pw12	44	1	Also	also	RB
cord-260577-t4w4pw12	44	2	,	,	,
cord-260577-t4w4pw12	44	3	it	-PRON-	PRP
cord-260577-t4w4pw12	44	4	has	have	VBZ
cord-260577-t4w4pw12	44	5	been	be	VBN
cord-260577-t4w4pw12	44	6	reported	report	VBN
cord-260577-t4w4pw12	44	7	that	that	IN
cord-260577-t4w4pw12	44	8	the	the	DT
cord-260577-t4w4pw12	44	9	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	44	10	capillary	capillary	NN
cord-260577-t4w4pw12	44	11	endotheliumbound	endotheliumbound	NN
cord-260577-t4w4pw12	44	12	(	(	-LRB-
cord-260577-t4w4pw12	44	13	PCEB	PCEB	NNP
cord-260577-t4w4pw12	44	14	)	)	-RRB-
cord-260577-t4w4pw12	45	1	ACE	ace	NN
cord-260577-t4w4pw12	45	2	activity	activity	NN
cord-260577-t4w4pw12	45	3	correlates	correlate	VBZ
cord-260577-t4w4pw12	45	4	with	with	IN
cord-260577-t4w4pw12	45	5	the	the	DT
cord-260577-t4w4pw12	45	6	severity	severity	NN
cord-260577-t4w4pw12	45	7	of	of	IN
cord-260577-t4w4pw12	45	8	lung	lung	NN
cord-260577-t4w4pw12	45	9	injury	injury	NN
cord-260577-t4w4pw12	45	10	in	in	IN
cord-260577-t4w4pw12	45	11	the	the	DT
cord-260577-t4w4pw12	45	12	patients	patient	NNS
cord-260577-t4w4pw12	45	13	with	with	IN
cord-260577-t4w4pw12	45	14	acute	acute	JJ
cord-260577-t4w4pw12	45	15	lung	lung	NN
cord-260577-t4w4pw12	45	16	injury	injury	NN
cord-260577-t4w4pw12	45	17	[	[	-LRB-
cord-260577-t4w4pw12	45	18	16	16	CD
cord-260577-t4w4pw12	45	19	]	]	-RRB-
cord-260577-t4w4pw12	45	20	.	.	.
cord-260577-t4w4pw12	46	1	These	these	DT
cord-260577-t4w4pw12	46	2	data	datum	NNS
cord-260577-t4w4pw12	46	3	suggest	suggest	VBP
cord-260577-t4w4pw12	46	4	the	the	DT
cord-260577-t4w4pw12	46	5	possible	possible	JJ
cord-260577-t4w4pw12	46	6	activation	activation	NN
cord-260577-t4w4pw12	46	7	of	of	IN
cord-260577-t4w4pw12	46	8	RAS	RAS	NNP
cord-260577-t4w4pw12	46	9	in	in	IN
cord-260577-t4w4pw12	46	10	patients	patient	NNS
cord-260577-t4w4pw12	46	11	with	with	IN
cord-260577-t4w4pw12	46	12	ARDS	ARDS	NNP
cord-260577-t4w4pw12	46	13	.	.	.
cord-260577-t4w4pw12	47	1	Interestingly	interestingly	RB
cord-260577-t4w4pw12	47	2	,	,	,
cord-260577-t4w4pw12	47	3	recent	recent	JJ
cord-260577-t4w4pw12	47	4	retrospective	retrospective	JJ
cord-260577-t4w4pw12	47	5	epidemiological	epidemiological	JJ
cord-260577-t4w4pw12	47	6	studies	study	NNS
cord-260577-t4w4pw12	47	7	demonstrated	demonstrate	VBD
cord-260577-t4w4pw12	47	8	that	that	IN
cord-260577-t4w4pw12	47	9	the	the	DT
cord-260577-t4w4pw12	47	10	prior	prior	JJ
cord-260577-t4w4pw12	47	11	outpatient	outpatient	NN
cord-260577-t4w4pw12	47	12	use	use	NN
cord-260577-t4w4pw12	47	13	of	of	IN
cord-260577-t4w4pw12	47	14	an	an	DT
cord-260577-t4w4pw12	47	15	ACE	ACE	NNP
cord-260577-t4w4pw12	47	16	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	47	17	was	be	VBD
cord-260577-t4w4pw12	47	18	associated	associate	VBN
cord-260577-t4w4pw12	47	19	with	with	IN
cord-260577-t4w4pw12	47	20	decreased	decrease	VBN
cord-260577-t4w4pw12	47	21	mortality	mortality	NN
cord-260577-t4w4pw12	47	22	in	in	IN
cord-260577-t4w4pw12	47	23	patients	patient	NNS
cord-260577-t4w4pw12	47	24	hospitalized	hospitalize	VBN
cord-260577-t4w4pw12	47	25	with	with	IN
cord-260577-t4w4pw12	47	26	community	community	NN
cord-260577-t4w4pw12	47	27	-	-	HYPH
cord-260577-t4w4pw12	47	28	acquired	acquire	VBN
cord-260577-t4w4pw12	47	29	pneumonia	pneumonia	NN
cord-260577-t4w4pw12	47	30	,	,	,
cord-260577-t4w4pw12	47	31	although	although	IN
cord-260577-t4w4pw12	47	32	further	further	JJ
cord-260577-t4w4pw12	47	33	studies	study	NNS
cord-260577-t4w4pw12	47	34	are	be	VBP
cord-260577-t4w4pw12	47	35	needed	need	VBN
cord-260577-t4w4pw12	47	36	to	to	TO
cord-260577-t4w4pw12	47	37	examine	examine	VB
cord-260577-t4w4pw12	47	38	whether	whether	IN
cord-260577-t4w4pw12	47	39	ACE	ace	NN
cord-260577-t4w4pw12	47	40	inhibitors	inhibitor	NNS
cord-260577-t4w4pw12	47	41	are	be	VBP
cord-260577-t4w4pw12	47	42	protective	protective	JJ
cord-260577-t4w4pw12	47	43	when	when	WRB
cord-260577-t4w4pw12	47	44	used	use	VBN
cord-260577-t4w4pw12	47	45	in	in	IN
cord-260577-t4w4pw12	47	46	an	an	DT
cord-260577-t4w4pw12	47	47	inpatient	inpatient	JJ
cord-260577-t4w4pw12	47	48	settings	setting	NNS
cord-260577-t4w4pw12	47	49	for	for	IN
cord-260577-t4w4pw12	47	50	patients	patient	NNS
cord-260577-t4w4pw12	47	51	lacking	lack	VBG
cord-260577-t4w4pw12	47	52	traditional	traditional	JJ
cord-260577-t4w4pw12	47	53	indications	indication	NNS
cord-260577-t4w4pw12	47	54	for	for	IN
cord-260577-t4w4pw12	47	55	the	the	DT
cord-260577-t4w4pw12	47	56	use	use	NN
cord-260577-t4w4pw12	47	57	of	of	IN
cord-260577-t4w4pw12	47	58	these	these	DT
cord-260577-t4w4pw12	47	59	medications	medication	NNS
cord-260577-t4w4pw12	47	60	[	[	-LRB-
cord-260577-t4w4pw12	47	61	17	17	CD
cord-260577-t4w4pw12	47	62	]	]	-RRB-
cord-260577-t4w4pw12	47	63	.	.	.
cord-260577-t4w4pw12	48	1	In	in	IN
cord-260577-t4w4pw12	48	2	2000	2000	CD
cord-260577-t4w4pw12	48	3	,	,	,
cord-260577-t4w4pw12	48	4	a	a	DT
cord-260577-t4w4pw12	48	5	novel	novel	JJ
cord-260577-t4w4pw12	48	6	homologue	homologue	NN
cord-260577-t4w4pw12	48	7	of	of	IN
cord-260577-t4w4pw12	48	8	ACE	ACE	NNP
cord-260577-t4w4pw12	48	9	was	be	VBD
cord-260577-t4w4pw12	48	10	cloned	clone	VBN
cord-260577-t4w4pw12	48	11	,	,	,
cord-260577-t4w4pw12	48	12	termed	term	VBN
cord-260577-t4w4pw12	48	13	ACE2	ACE2	NNP
cord-260577-t4w4pw12	48	14	[	[	-LRB-
cord-260577-t4w4pw12	48	15	3	3	CD
cord-260577-t4w4pw12	48	16	,	,	,
cord-260577-t4w4pw12	48	17	4	4	CD
cord-260577-t4w4pw12	48	18	]	]	-RRB-
cord-260577-t4w4pw12	48	19	.	.	.
cord-260577-t4w4pw12	49	1	ACE	ACE	NNP
cord-260577-t4w4pw12	49	2	and	and	CC
cord-260577-t4w4pw12	49	3	ACE2	ACE2	NNP
cord-260577-t4w4pw12	49	4	share	share	NN
cord-260577-t4w4pw12	49	5	homology	homology	NN
cord-260577-t4w4pw12	49	6	in	in	IN
cord-260577-t4w4pw12	49	7	their	-PRON-	PRP$
cord-260577-t4w4pw12	49	8	catalytic	catalytic	JJ
cord-260577-t4w4pw12	49	9	domain	domain	NN
cord-260577-t4w4pw12	49	10	and	and	CC
cord-260577-t4w4pw12	49	11	provide	provide	VB
cord-260577-t4w4pw12	49	12	different	different	JJ
cord-260577-t4w4pw12	49	13	key	key	JJ
cord-260577-t4w4pw12	49	14	functions	function	NNS
cord-260577-t4w4pw12	49	15	in	in	IN
cord-260577-t4w4pw12	49	16	the	the	DT
cord-260577-t4w4pw12	49	17	RAS	RAS	NNP
cord-260577-t4w4pw12	49	18	.	.	.
cord-260577-t4w4pw12	50	1	ACE	ACE	NNP
cord-260577-t4w4pw12	50	2	cleaves	cleave	VBZ
cord-260577-t4w4pw12	51	1	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	51	2	I	-PRON-	PRP
cord-260577-t4w4pw12	51	3	to	to	TO
cord-260577-t4w4pw12	51	4	generate	generate	VB
cord-260577-t4w4pw12	51	5	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	51	6	II	II	NNP
cord-260577-t4w4pw12	51	7	[	[	-LRB-
cord-260577-t4w4pw12	51	8	1	1	CD
cord-260577-t4w4pw12	51	9	,	,	,
cord-260577-t4w4pw12	51	10	2	2	CD
cord-260577-t4w4pw12	51	11	]	]	-RRB-
cord-260577-t4w4pw12	51	12	,	,	,
cord-260577-t4w4pw12	51	13	whereas	whereas	IN
cord-260577-t4w4pw12	51	14	ACE2	ACE2	NNP
cord-260577-t4w4pw12	51	15	reduces	reduce	VBZ
cord-260577-t4w4pw12	51	16	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	51	17	II	ii	CD
cord-260577-t4w4pw12	51	18	levels	level	NNS
cord-260577-t4w4pw12	51	19	[	[	-LRB-
cord-260577-t4w4pw12	51	20	3	3	CD
cord-260577-t4w4pw12	51	21	,	,	,
cord-260577-t4w4pw12	51	22	4	4	CD
cord-260577-t4w4pw12	51	23	]	]	-RRB-
cord-260577-t4w4pw12	51	24	.	.	.
cord-260577-t4w4pw12	52	1	The	the	DT
cord-260577-t4w4pw12	52	2	biological	biological	JJ
cord-260577-t4w4pw12	52	3	effects	effect	NNS
cord-260577-t4w4pw12	52	4	of	of	IN
cord-260577-t4w4pw12	52	5	Ang	Ang	NNP
cord-260577-t4w4pw12	52	6	II	II	NNP
cord-260577-t4w4pw12	52	7	are	be	VBP
cord-260577-t4w4pw12	52	8	mediated	mediate	VBN
cord-260577-t4w4pw12	52	9	through	through	IN
cord-260577-t4w4pw12	52	10	two	two	CD
cord-260577-t4w4pw12	52	11	specific	specific	JJ
cord-260577-t4w4pw12	52	12	receptors	receptor	NNS
cord-260577-t4w4pw12	52	13	,	,	,
cord-260577-t4w4pw12	52	14	Ang	Ang	NNP
cord-260577-t4w4pw12	52	15	II	II	NNP
cord-260577-t4w4pw12	52	16	receptor	receptor	NN
cord-260577-t4w4pw12	52	17	type	type	NN
cord-260577-t4w4pw12	52	18	1	1	CD
cord-260577-t4w4pw12	52	19	(	(	-LRB-
cord-260577-t4w4pw12	52	20	AT	at	IN
cord-260577-t4w4pw12	52	21	1	1	CD
cord-260577-t4w4pw12	52	22	R	r	NN
cord-260577-t4w4pw12	52	23	)	)	-RRB-
cord-260577-t4w4pw12	52	24	and	and	CC
cord-260577-t4w4pw12	52	25	Ang	Ang	NNP
cord-260577-t4w4pw12	52	26	II	II	NNP
cord-260577-t4w4pw12	52	27	receptor	receptor	NN
cord-260577-t4w4pw12	52	28	type	type	NN
cord-260577-t4w4pw12	52	29	2	2	CD
cord-260577-t4w4pw12	52	30	(	(	-LRB-
cord-260577-t4w4pw12	52	31	AT	at	IN
cord-260577-t4w4pw12	52	32	2	2	CD
cord-260577-t4w4pw12	52	33	R	r	NN
cord-260577-t4w4pw12	52	34	)	)	-RRB-
cord-260577-t4w4pw12	52	35	[	[	-LRB-
cord-260577-t4w4pw12	52	36	1	1	CD
cord-260577-t4w4pw12	52	37	,	,	,
cord-260577-t4w4pw12	52	38	2	2	CD
cord-260577-t4w4pw12	52	39	]	]	-RRB-
cord-260577-t4w4pw12	52	40	.	.	.
cord-260577-t4w4pw12	53	1	The	the	DT
cord-260577-t4w4pw12	53	2	targeted	target	VBN
cord-260577-t4w4pw12	53	3	disruption	disruption	NN
cord-260577-t4w4pw12	53	4	of	of	IN
cord-260577-t4w4pw12	53	5	murine	murine	JJ
cord-260577-t4w4pw12	53	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	53	7	resulted	result	VBD
cord-260577-t4w4pw12	53	8	in	in	IN
cord-260577-t4w4pw12	53	9	increased	increase	VBN
cord-260577-t4w4pw12	53	10	Ang	Ang	NNP
cord-260577-t4w4pw12	53	11	II	II	NNP
cord-260577-t4w4pw12	53	12	levels	level	NNS
cord-260577-t4w4pw12	53	13	,	,	,
cord-260577-t4w4pw12	53	14	impaired	impair	VBN
cord-260577-t4w4pw12	53	15	cardiac	cardiac	JJ
cord-260577-t4w4pw12	53	16	contractility	contractility	NN
cord-260577-t4w4pw12	53	17	in	in	IN
cord-260577-t4w4pw12	53	18	aged	aged	JJ
cord-260577-t4w4pw12	53	19	mice	mouse	NNS
cord-260577-t4w4pw12	53	20	,	,	,
cord-260577-t4w4pw12	53	21	upregulation	upregulation	NN
cord-260577-t4w4pw12	53	22	of	of	IN
cord-260577-t4w4pw12	53	23	hypoxia	hypoxia	NN
cord-260577-t4w4pw12	53	24	-	-	HYPH
cord-260577-t4w4pw12	53	25	induced	induce	VBN
cord-260577-t4w4pw12	53	26	genes	gene	NNS
cord-260577-t4w4pw12	53	27	in	in	IN
cord-260577-t4w4pw12	53	28	the	the	DT
cord-260577-t4w4pw12	53	29	heart	heart	NN
cord-260577-t4w4pw12	53	30	[	[	-LRB-
cord-260577-t4w4pw12	53	31	18	18	CD
cord-260577-t4w4pw12	53	32	]	]	-RRB-
cord-260577-t4w4pw12	53	33	and	and	CC
cord-260577-t4w4pw12	53	34	worsened	worsen	VBD
cord-260577-t4w4pw12	53	35	heart	heart	NN
cord-260577-t4w4pw12	53	36	failure	failure	NN
cord-260577-t4w4pw12	53	37	following	follow	VBG
cord-260577-t4w4pw12	53	38	aortic	aortic	JJ
cord-260577-t4w4pw12	53	39	banding	banding	NN
cord-260577-t4w4pw12	53	40	[	[	-LRB-
cord-260577-t4w4pw12	53	41	19	19	CD
cord-260577-t4w4pw12	53	42	]	]	-RRB-
cord-260577-t4w4pw12	53	43	.	.	.
cord-260577-t4w4pw12	54	1	Loss	loss	NN
cord-260577-t4w4pw12	54	2	of	of	IN
cord-260577-t4w4pw12	54	3	ACE	ace	NN
cord-260577-t4w4pw12	54	4	on	on	IN
cord-260577-t4w4pw12	54	5	an	an	DT
cord-260577-t4w4pw12	54	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	54	7	background	background	NN
cord-260577-t4w4pw12	54	8	or	or	CC
cord-260577-t4w4pw12	54	9	pharmacological	pharmacological	JJ
cord-260577-t4w4pw12	54	10	inhibition	inhibition	NN
cord-260577-t4w4pw12	54	11	of	of	IN
cord-260577-t4w4pw12	54	12	the	the	DT
cord-260577-t4w4pw12	54	13	RAS	RAS	NNP
cord-260577-t4w4pw12	54	14	can	can	MD
cord-260577-t4w4pw12	54	15	at	at	IN
cord-260577-t4w4pw12	54	16	least	least	RBS
cord-260577-t4w4pw12	54	17	partially	partially	RB
cord-260577-t4w4pw12	54	18	reverse	reverse	VB
cord-260577-t4w4pw12	54	19	the	the	DT
cord-260577-t4w4pw12	54	20	cardiac	cardiac	JJ
cord-260577-t4w4pw12	54	21	phenotypes	phenotype	NNS
cord-260577-t4w4pw12	54	22	[	[	-LRB-
cord-260577-t4w4pw12	54	23	18	18	CD
cord-260577-t4w4pw12	54	24	]	]	-RRB-
cord-260577-t4w4pw12	54	25	.	.	.
cord-260577-t4w4pw12	55	1	These	these	DT
cord-260577-t4w4pw12	55	2	genetic	genetic	JJ
cord-260577-t4w4pw12	55	3	data	datum	NNS
cord-260577-t4w4pw12	55	4	demonstrate	demonstrate	VBP
cord-260577-t4w4pw12	55	5	that	that	IN
cord-260577-t4w4pw12	55	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	55	7	counterbalances	counterbalance	VBZ
cord-260577-t4w4pw12	55	8	the	the	DT
cord-260577-t4w4pw12	55	9	function	function	NN
cord-260577-t4w4pw12	55	10	of	of	IN
cord-260577-t4w4pw12	55	11	ACE	ace	NN
cord-260577-t4w4pw12	55	12	and	and	CC
cord-260577-t4w4pw12	55	13	negatively	negatively	RB
cord-260577-t4w4pw12	55	14	regulates	regulate	VBZ
cord-260577-t4w4pw12	55	15	Ang	Ang	NNP
cord-260577-t4w4pw12	55	16	II	II	NNP
cord-260577-t4w4pw12	55	17	levels	level	NNS
cord-260577-t4w4pw12	55	18	within	within	IN
cord-260577-t4w4pw12	55	19	the	the	DT
cord-260577-t4w4pw12	55	20	RAS	RAS	NNP
cord-260577-t4w4pw12	55	21	(	(	-LRB-
cord-260577-t4w4pw12	55	22	Fig	Fig	NNP
cord-260577-t4w4pw12	55	23	.	.	.
cord-260577-t4w4pw12	55	24	1	1	CD
cord-260577-t4w4pw12	55	25	)	)	-RRB-
cord-260577-t4w4pw12	55	26	.	.	.
cord-260577-t4w4pw12	56	1	Our	-PRON-	PRP$
cord-260577-t4w4pw12	56	2	group	group	NN
cord-260577-t4w4pw12	56	3	has	have	VBZ
cord-260577-t4w4pw12	56	4	investigated	investigate	VBN
cord-260577-t4w4pw12	56	5	the	the	DT
cord-260577-t4w4pw12	56	6	role	role	NN
cord-260577-t4w4pw12	56	7	of	of	IN
cord-260577-t4w4pw12	56	8	ACE2	ACE2	NNP
cord-260577-t4w4pw12	56	9	in	in	IN
cord-260577-t4w4pw12	56	10	ARDS	ARDS	NNP
cord-260577-t4w4pw12	56	11	using	use	VBG
cord-260577-t4w4pw12	56	12	ace2	ace2	NNP
cord-260577-t4w4pw12	56	13	knockout	knockout	NN
cord-260577-t4w4pw12	56	14	mice	mouse	NNS
cord-260577-t4w4pw12	56	15	[	[	-LRB-
cord-260577-t4w4pw12	56	16	7	7	CD
cord-260577-t4w4pw12	56	17	]	]	-RRB-
cord-260577-t4w4pw12	56	18	.	.	.
cord-260577-t4w4pw12	57	1	In	in	IN
cord-260577-t4w4pw12	57	2	acid	acid	JJ
cord-260577-t4w4pw12	57	3	aspiration	aspiration	NN
cord-260577-t4w4pw12	57	4	-	-	HYPH
cord-260577-t4w4pw12	57	5	induced	induce	VBN
cord-260577-t4w4pw12	57	6	ARDS	ARDS	NNP
cord-260577-t4w4pw12	57	7	,	,	,
cord-260577-t4w4pw12	57	8	endotoxin	endotoxin	NN
cord-260577-t4w4pw12	57	9	-	-	HYPH
cord-260577-t4w4pw12	57	10	induced	induce	VBN
cord-260577-t4w4pw12	57	11	ARDS	ARDS	NNP
cord-260577-t4w4pw12	57	12	,	,	,
cord-260577-t4w4pw12	57	13	as	as	RB
cord-260577-t4w4pw12	57	14	well	well	RB
cord-260577-t4w4pw12	57	15	as	as	IN
cord-260577-t4w4pw12	57	16	peritoneal	peritoneal	NN
cord-260577-t4w4pw12	57	17	sepsisinduced	sepsisinduce	VBN
cord-260577-t4w4pw12	57	18	ARDS	ARDS	NNP
cord-260577-t4w4pw12	57	19	,	,	,
cord-260577-t4w4pw12	57	20	ace2	ace2	NNP
cord-260577-t4w4pw12	57	21	knockout	knockout	NN
cord-260577-t4w4pw12	57	22	mice	mouse	NNS
cord-260577-t4w4pw12	57	23	exhibited	exhibit	VBD
cord-260577-t4w4pw12	57	24	very	very	RB
cord-260577-t4w4pw12	57	25	severe	severe	JJ
cord-260577-t4w4pw12	57	26	disease	disease	NN
cord-260577-t4w4pw12	57	27	compared	compare	VBN
cord-260577-t4w4pw12	57	28	with	with	IN
cord-260577-t4w4pw12	57	29	control	control	NN
cord-260577-t4w4pw12	57	30	mice	mouse	NNS
cord-260577-t4w4pw12	57	31	that	that	WDT
cord-260577-t4w4pw12	57	32	express	express	VBP
cord-260577-t4w4pw12	57	33	ACE2	ACE2	NNP
cord-260577-t4w4pw12	57	34	.	.	.
cord-260577-t4w4pw12	58	1	Loss	loss	NN
cord-260577-t4w4pw12	58	2	of	of	IN
cord-260577-t4w4pw12	58	3	ACE2	ACE2	NNP
cord-260577-t4w4pw12	58	4	expression	expression	NN
cord-260577-t4w4pw12	58	5	in	in	IN
cord-260577-t4w4pw12	58	6	mutant	mutant	JJ
cord-260577-t4w4pw12	58	7	mice	mouse	NNS
cord-260577-t4w4pw12	58	8	also	also	RB
cord-260577-t4w4pw12	58	9	resulted	result	VBD
cord-260577-t4w4pw12	58	10	in	in	IN
cord-260577-t4w4pw12	58	11	enhanced	enhanced	JJ
cord-260577-t4w4pw12	58	12	vascular	vascular	JJ
cord-260577-t4w4pw12	58	13	permeability	permeability	NN
cord-260577-t4w4pw12	58	14	,	,	,
cord-260577-t4w4pw12	58	15	increased	increase	VBN
cord-260577-t4w4pw12	58	16	lung	lung	NN
cord-260577-t4w4pw12	58	17	edema	edema	NN
cord-260577-t4w4pw12	58	18	,	,	,
cord-260577-t4w4pw12	58	19	neutrophil	neutrophil	NN
cord-260577-t4w4pw12	58	20	accumulation	accumulation	NN
cord-260577-t4w4pw12	58	21	and	and	CC
cord-260577-t4w4pw12	58	22	worsened	worsen	VBD
cord-260577-t4w4pw12	58	23	lung	lung	NN
cord-260577-t4w4pw12	58	24	function	function	NN
cord-260577-t4w4pw12	58	25	.	.	.
cord-260577-t4w4pw12	59	1	Of	of	IN
cord-260577-t4w4pw12	59	2	note	note	NN
cord-260577-t4w4pw12	59	3	,	,	,
cord-260577-t4w4pw12	59	4	these	these	DT
cord-260577-t4w4pw12	59	5	pathologic	pathologic	JJ
cord-260577-t4w4pw12	59	6	manifestations	manifestation	NNS
cord-260577-t4w4pw12	59	7	occurred	occur	VBD
cord-260577-t4w4pw12	59	8	without	without	IN
cord-260577-t4w4pw12	59	9	apparent	apparent	JJ
cord-260577-t4w4pw12	59	10	changes	change	NNS
cord-260577-t4w4pw12	59	11	in	in	IN
cord-260577-t4w4pw12	59	12	heart	heart	NN
cord-260577-t4w4pw12	59	13	contractility	contractility	NN
cord-260577-t4w4pw12	59	14	or	or	CC
cord-260577-t4w4pw12	59	15	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	59	16	vascular	vascular	JJ
cord-260577-t4w4pw12	59	17	tone	tone	NN
cord-260577-t4w4pw12	59	18	among	among	IN
cord-260577-t4w4pw12	59	19	the	the	DT
cord-260577-t4w4pw12	59	20	experimental	experimental	JJ
cord-260577-t4w4pw12	59	21	groups	group	NNS
cord-260577-t4w4pw12	59	22	.	.	.
cord-260577-t4w4pw12	60	1	Mechanistically	Mechanistically	NNP
cord-260577-t4w4pw12	60	2	,	,	,
cord-260577-t4w4pw12	60	3	the	the	DT
cord-260577-t4w4pw12	60	4	negative	negative	JJ
cord-260577-t4w4pw12	60	5	regulation	regulation	NN
cord-260577-t4w4pw12	60	6	of	of	IN
cord-260577-t4w4pw12	60	7	Ang	Ang	NNP
cord-260577-t4w4pw12	60	8	II	II	NNP
cord-260577-t4w4pw12	60	9	levels	level	NNS
cord-260577-t4w4pw12	60	10	by	by	IN
cord-260577-t4w4pw12	60	11	ACE2	ACE2	NNP
cord-260577-t4w4pw12	60	12	accounts	account	NNS
cord-260577-t4w4pw12	60	13	,	,	,
cord-260577-t4w4pw12	60	14	in	in	IN
cord-260577-t4w4pw12	60	15	part	part	NN
cord-260577-t4w4pw12	60	16	,	,	,
cord-260577-t4w4pw12	60	17	for	for	IN
cord-260577-t4w4pw12	60	18	the	the	DT
cord-260577-t4w4pw12	60	19	protective	protective	JJ
cord-260577-t4w4pw12	60	20	function	function	NN
cord-260577-t4w4pw12	60	21	of	of	IN
cord-260577-t4w4pw12	60	22	ACE2	ACE2	NNP
cord-260577-t4w4pw12	60	23	in	in	IN
cord-260577-t4w4pw12	60	24	ARDS	ARDS	NNP
cord-260577-t4w4pw12	60	25	.	.	.
cord-260577-t4w4pw12	61	1	For	for	IN
cord-260577-t4w4pw12	61	2	example	example	NN
cord-260577-t4w4pw12	61	3	,	,	,
cord-260577-t4w4pw12	61	4	AT	at	IN
cord-260577-t4w4pw12	61	5	1	1	CD
cord-260577-t4w4pw12	61	6	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	61	7	treatment	treatment	NN
cord-260577-t4w4pw12	61	8	or	or	CC
cord-260577-t4w4pw12	61	9	additional	additional	JJ
cord-260577-t4w4pw12	61	10	ace	ace	NN
cord-260577-t4w4pw12	61	11	gene	gene	NN
cord-260577-t4w4pw12	61	12	deficiency	deficiency	NN
cord-260577-t4w4pw12	61	13	on	on	IN
cord-260577-t4w4pw12	61	14	an	an	DT
cord-260577-t4w4pw12	61	15	ace2	ace2	NNP
cord-260577-t4w4pw12	61	16	knockout	knockout	NN
cord-260577-t4w4pw12	61	17	background	background	NN
cord-260577-t4w4pw12	61	18	rescues	rescue	VBZ
cord-260577-t4w4pw12	61	19	the	the	DT
cord-260577-t4w4pw12	61	20	severe	severe	JJ
cord-260577-t4w4pw12	61	21	phenotype	phenotype	NN
cord-260577-t4w4pw12	61	22	of	of	IN
cord-260577-t4w4pw12	61	23	ace2	ace2	DT
cord-260577-t4w4pw12	61	24	single	single	JJ
cord-260577-t4w4pw12	61	25	mutant	mutant	JJ
cord-260577-t4w4pw12	61	26	mice	mouse	NNS
cord-260577-t4w4pw12	61	27	in	in	IN
cord-260577-t4w4pw12	61	28	acute	acute	JJ
cord-260577-t4w4pw12	61	29	lung	lung	NN
cord-260577-t4w4pw12	61	30	injury	injury	NN
cord-260577-t4w4pw12	61	31	.	.	.
cord-260577-t4w4pw12	62	1	In	in	IN
cord-260577-t4w4pw12	62	2	addition	addition	NN
cord-260577-t4w4pw12	62	3	,	,	,
cord-260577-t4w4pw12	62	4	ace	ace	NN
cord-260577-t4w4pw12	62	5	knockout	knockout	NN
cord-260577-t4w4pw12	62	6	mice	mouse	NNS
cord-260577-t4w4pw12	62	7	and	and	CC
cord-260577-t4w4pw12	62	8	AT	at	IN
cord-260577-t4w4pw12	62	9	1	1	CD
cord-260577-t4w4pw12	62	10	R	r	NN
cord-260577-t4w4pw12	62	11	knockout	knockout	NN
cord-260577-t4w4pw12	62	12	mice	mouse	NNS
cord-260577-t4w4pw12	62	13	,	,	,
cord-260577-t4w4pw12	62	14	but	but	CC
cord-260577-t4w4pw12	62	15	not	not	RB
cord-260577-t4w4pw12	62	16	AT	at	IN
cord-260577-t4w4pw12	62	17	2	2	CD
cord-260577-t4w4pw12	62	18	R	r	NN
cord-260577-t4w4pw12	62	19	knockout	knockout	NN
cord-260577-t4w4pw12	62	20	mice	mouse	NNS
cord-260577-t4w4pw12	62	21	,	,	,
cord-260577-t4w4pw12	62	22	showed	show	VBD
cord-260577-t4w4pw12	62	23	improved	improved	JJ
cord-260577-t4w4pw12	62	24	symptoms	symptom	NNS
cord-260577-t4w4pw12	62	25	of	of	IN
cord-260577-t4w4pw12	62	26	acute	acute	JJ
cord-260577-t4w4pw12	62	27	lung	lung	NN
cord-260577-t4w4pw12	62	28	injury	injury	NN
cord-260577-t4w4pw12	62	29	.	.	.
cord-260577-t4w4pw12	63	1	Therefore	therefore	RB
cord-260577-t4w4pw12	63	2	,	,	,
cord-260577-t4w4pw12	63	3	in	in	IN
cord-260577-t4w4pw12	63	4	acute	acute	JJ
cord-260577-t4w4pw12	63	5	lung	lung	NN
cord-260577-t4w4pw12	63	6	injury	injury	NN
cord-260577-t4w4pw12	63	7	,	,	,
cord-260577-t4w4pw12	63	8	ACE	ACE	NNP
cord-260577-t4w4pw12	63	9	,	,	,
cord-260577-t4w4pw12	63	10	Ang	Ang	NNP
cord-260577-t4w4pw12	63	11	II	II	NNP
cord-260577-t4w4pw12	63	12	and	and	CC
cord-260577-t4w4pw12	63	13	AT	at	IN
cord-260577-t4w4pw12	63	14	1	1	CD
cord-260577-t4w4pw12	63	15	R	r	NN
cord-260577-t4w4pw12	63	16	promote	promote	VBP
cord-260577-t4w4pw12	63	17	acute	acute	JJ
cord-260577-t4w4pw12	63	18	lung	lung	NN
cord-260577-t4w4pw12	63	19	injury	injury	NN
cord-260577-t4w4pw12	63	20	,	,	,
cord-260577-t4w4pw12	63	21	whereas	whereas	IN
cord-260577-t4w4pw12	63	22	ACE2	ACE2	NNP
cord-260577-t4w4pw12	63	23	and	and	CC
cord-260577-t4w4pw12	63	24	the	the	DT
cord-260577-t4w4pw12	63	25	AT	AT	NNP
cord-260577-t4w4pw12	63	26	2	2	CD
cord-260577-t4w4pw12	63	27	R	r	NN
cord-260577-t4w4pw12	63	28	Figure	figure	NN
cord-260577-t4w4pw12	63	29	1	1	CD
cord-260577-t4w4pw12	63	30	.	.	.
cord-260577-t4w4pw12	64	1	Current	current	JJ
cord-260577-t4w4pw12	64	2	view	view	NN
cord-260577-t4w4pw12	64	3	of	of	IN
cord-260577-t4w4pw12	64	4	the	the	DT
cord-260577-t4w4pw12	64	5	renin	renin	NN
cord-260577-t4w4pw12	64	6	-	-	HYPH
cord-260577-t4w4pw12	64	7	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	64	8	system	system	NN
cord-260577-t4w4pw12	64	9	.	.	.
cord-260577-t4w4pw12	65	1	Angiotensin	angiotensin	NN
cord-260577-t4w4pw12	65	2	I	-PRON-	PRP
cord-260577-t4w4pw12	65	3	serves	serve	VBZ
cord-260577-t4w4pw12	65	4	as	as	IN
cord-260577-t4w4pw12	65	5	a	a	DT
cord-260577-t4w4pw12	65	6	substrate	substrate	NN
cord-260577-t4w4pw12	65	7	for	for	IN
cord-260577-t4w4pw12	65	8	both	both	CC
cord-260577-t4w4pw12	65	9	ACE	ACE	NNP
cord-260577-t4w4pw12	65	10	and	and	CC
cord-260577-t4w4pw12	65	11	ACE2	ACE2	NNP
cord-260577-t4w4pw12	65	12	.	.	.
cord-260577-t4w4pw12	66	1	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	66	2	II	II	NNP
cord-260577-t4w4pw12	66	3	is	be	VBZ
cord-260577-t4w4pw12	66	4	known	know	VBN
cord-260577-t4w4pw12	66	5	to	to	TO
cord-260577-t4w4pw12	66	6	act	act	VB
cord-260577-t4w4pw12	66	7	as	as	IN
cord-260577-t4w4pw12	66	8	vasoconstrictor	vasoconstrictor	NN
cord-260577-t4w4pw12	66	9	as	as	RB
cord-260577-t4w4pw12	66	10	well	well	RB
cord-260577-t4w4pw12	66	11	as	as	IN
cord-260577-t4w4pw12	66	12	mitogen	mitogen	NNP
cord-260577-t4w4pw12	66	13	for	for	IN
cord-260577-t4w4pw12	66	14	smooth	smooth	JJ
cord-260577-t4w4pw12	66	15	muscle	muscle	NN
cord-260577-t4w4pw12	66	16	cells	cell	NNS
cord-260577-t4w4pw12	66	17	or	or	CC
cord-260577-t4w4pw12	66	18	fibroblasts	fibroblast	NNS
cord-260577-t4w4pw12	66	19	,	,	,
cord-260577-t4w4pw12	66	20	mainly	mainly	RB
cord-260577-t4w4pw12	66	21	through	through	IN
cord-260577-t4w4pw12	66	22	the	the	DT
cord-260577-t4w4pw12	66	23	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	66	24	II	II	NNP
cord-260577-t4w4pw12	66	25	type	type	NN
cord-260577-t4w4pw12	66	26	1	1	CD
cord-260577-t4w4pw12	66	27	receptor	receptor	NN
cord-260577-t4w4pw12	66	28	.	.	.
cord-260577-t4w4pw12	67	1	The	the	DT
cord-260577-t4w4pw12	67	2	function	function	NN
cord-260577-t4w4pw12	67	3	of	of	IN
cord-260577-t4w4pw12	67	4	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	67	5	1	1	CD
cord-260577-t4w4pw12	67	6	-	-	SYM
cord-260577-t4w4pw12	67	7	9	9	CD
cord-260577-t4w4pw12	67	8	is	be	VBZ
cord-260577-t4w4pw12	67	9	not	not	RB
cord-260577-t4w4pw12	67	10	well	well	RB
cord-260577-t4w4pw12	67	11	understood	understand	VBN
cord-260577-t4w4pw12	67	12	.	.	.
cord-260577-t4w4pw12	68	1	Both	both	CC
cord-260577-t4w4pw12	68	2	ACE	ACE	NNP
cord-260577-t4w4pw12	68	3	and	and	CC
cord-260577-t4w4pw12	68	4	ACE2	ACE2	NNP
cord-260577-t4w4pw12	68	5	are	be	VBP
cord-260577-t4w4pw12	68	6	involved	involve	VBN
cord-260577-t4w4pw12	68	7	in	in	IN
cord-260577-t4w4pw12	68	8	the	the	DT
cord-260577-t4w4pw12	68	9	production	production	NN
cord-260577-t4w4pw12	68	10	of	of	IN
cord-260577-t4w4pw12	68	11	the	the	DT
cord-260577-t4w4pw12	68	12	vasodilator	vasodilator	NN
cord-260577-t4w4pw12	68	13	peptide	peptide	NN
cord-260577-t4w4pw12	68	14	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	68	15	1	1	CD
cord-260577-t4w4pw12	68	16	-	-	SYM
cord-260577-t4w4pw12	68	17	7	7	CD
cord-260577-t4w4pw12	68	18	.	.	.
cord-260577-t4w4pw12	69	1	protect	protect	VB
cord-260577-t4w4pw12	69	2	from	from	IN
cord-260577-t4w4pw12	69	3	lung	lung	NN
cord-260577-t4w4pw12	69	4	injury	injury	NN
cord-260577-t4w4pw12	69	5	[	[	-LRB-
cord-260577-t4w4pw12	69	6	7	7	CD
cord-260577-t4w4pw12	69	7	]	]	-RRB-
cord-260577-t4w4pw12	69	8	.	.	.
cord-260577-t4w4pw12	70	1	Importantly	importantly	RB
cord-260577-t4w4pw12	70	2	,	,	,
cord-260577-t4w4pw12	70	3	the	the	DT
cord-260577-t4w4pw12	70	4	treatment	treatment	NN
cord-260577-t4w4pw12	70	5	with	with	IN
cord-260577-t4w4pw12	70	6	catalytically	catalytically	RB
cord-260577-t4w4pw12	70	7	active	active	JJ
cord-260577-t4w4pw12	70	8	,	,	,
cord-260577-t4w4pw12	70	9	but	but	CC
cord-260577-t4w4pw12	70	10	not	not	RB
cord-260577-t4w4pw12	70	11	enzymatically	enzymatically	RB
cord-260577-t4w4pw12	70	12	inactive	inactive	JJ
cord-260577-t4w4pw12	70	13	,	,	,
cord-260577-t4w4pw12	70	14	recombinant	recombinant	JJ
cord-260577-t4w4pw12	70	15	ACE2	ACE2	NNP
cord-260577-t4w4pw12	70	16	protein	protein	NN
cord-260577-t4w4pw12	70	17	improved	improve	VBD
cord-260577-t4w4pw12	70	18	the	the	DT
cord-260577-t4w4pw12	70	19	symptoms	symptom	NNS
cord-260577-t4w4pw12	70	20	of	of	IN
cord-260577-t4w4pw12	70	21	acute	acute	JJ
cord-260577-t4w4pw12	70	22	lung	lung	NN
cord-260577-t4w4pw12	70	23	injury	injury	NN
cord-260577-t4w4pw12	70	24	in	in	IN
cord-260577-t4w4pw12	70	25	wild	wild	JJ
cord-260577-t4w4pw12	70	26	type	type	NN
cord-260577-t4w4pw12	70	27	mice	mouse	NNS
cord-260577-t4w4pw12	70	28	as	as	RB
cord-260577-t4w4pw12	70	29	well	well	RB
cord-260577-t4w4pw12	70	30	as	as	IN
cord-260577-t4w4pw12	70	31	in	in	IN
cord-260577-t4w4pw12	70	32	ace2	ace2	NNP
cord-260577-t4w4pw12	70	33	knockout	knockout	NN
cord-260577-t4w4pw12	70	34	mice	mouse	NNS
cord-260577-t4w4pw12	70	35	,	,	,
cord-260577-t4w4pw12	70	36	suggesting	suggest	VBG
cord-260577-t4w4pw12	70	37	ACE2	ACE2	NNP
cord-260577-t4w4pw12	70	38	protein	protein	NN
cord-260577-t4w4pw12	70	39	as	as	IN
cord-260577-t4w4pw12	70	40	a	a	DT
cord-260577-t4w4pw12	70	41	possible	possible	JJ
cord-260577-t4w4pw12	70	42	novel	novel	JJ
cord-260577-t4w4pw12	70	43	therapeutic	therapeutic	JJ
cord-260577-t4w4pw12	70	44	target	target	NN
cord-260577-t4w4pw12	70	45	for	for	IN
cord-260577-t4w4pw12	70	46	ARDS	ARDS	NNP
cord-260577-t4w4pw12	70	47	(	(	-LRB-
cord-260577-t4w4pw12	70	48	Fig	Fig	NNP
cord-260577-t4w4pw12	70	49	.	.	NNP
cord-260577-t4w4pw12	70	50	2	2	CD
cord-260577-t4w4pw12	70	51	)	)	-RRB-
cord-260577-t4w4pw12	70	52	.	.	.
cord-260577-t4w4pw12	71	1	Within	within	IN
cord-260577-t4w4pw12	71	2	a	a	DT
cord-260577-t4w4pw12	71	3	few	few	JJ
cord-260577-t4w4pw12	71	4	months	month	NNS
cord-260577-t4w4pw12	71	5	following	follow	VBG
cord-260577-t4w4pw12	71	6	the	the	DT
cord-260577-t4w4pw12	71	7	publication	publication	NN
cord-260577-t4w4pw12	71	8	of	of	IN
cord-260577-t4w4pw12	71	9	the	the	DT
cord-260577-t4w4pw12	71	10	SARS	SARS	NNP
cord-260577-t4w4pw12	71	11	-	-	HYPH
cord-260577-t4w4pw12	71	12	CoV	CoV	NNP
cord-260577-t4w4pw12	71	13	genome	genome	NN
cord-260577-t4w4pw12	71	14	,	,	,
cord-260577-t4w4pw12	71	15	ACE2	ACE2	NNP
cord-260577-t4w4pw12	71	16	was	be	VBD
cord-260577-t4w4pw12	71	17	identified	identify	VBN
cord-260577-t4w4pw12	71	18	as	as	IN
cord-260577-t4w4pw12	71	19	a	a	DT
cord-260577-t4w4pw12	71	20	potential	potential	JJ
cord-260577-t4w4pw12	71	21	receptor	receptor	NN
cord-260577-t4w4pw12	71	22	in	in	IN
cord-260577-t4w4pw12	71	23	cell	cell	NN
cord-260577-t4w4pw12	71	24	line	line	NN
cord-260577-t4w4pw12	71	25	studies	study	NNS
cord-260577-t4w4pw12	71	26	in	in	IN
cord-260577-t4w4pw12	71	27	vitro	vitro	FW
cord-260577-t4w4pw12	71	28	[	[	-LRB-
cord-260577-t4w4pw12	71	29	5	5	CD
cord-260577-t4w4pw12	71	30	]	]	-RRB-
cord-260577-t4w4pw12	71	31	.	.	.
cord-260577-t4w4pw12	72	1	ACE2	ACE2	NNP
cord-260577-t4w4pw12	72	2	binds	bind	VBZ
cord-260577-t4w4pw12	72	3	SARS	SARS	NNP
cord-260577-t4w4pw12	72	4	-	-	HYPH
cord-260577-t4w4pw12	72	5	CoV	cov	NN
cord-260577-t4w4pw12	72	6	spike	spike	NN
cord-260577-t4w4pw12	72	7	and	and	CC
cord-260577-t4w4pw12	72	8	supports	support	VBZ
cord-260577-t4w4pw12	72	9	'	'	POS
cord-260577-t4w4pw12	72	10	syncytia	syncytia	NN
cord-260577-t4w4pw12	72	11	formation	formation	NN
cord-260577-t4w4pw12	72	12	'	'	''
cord-260577-t4w4pw12	72	13	,	,	,
cord-260577-t4w4pw12	72	14	the	the	DT
cord-260577-t4w4pw12	72	15	fusion	fusion	NN
cord-260577-t4w4pw12	72	16	of	of	IN
cord-260577-t4w4pw12	72	17	spike	spike	NN
cord-260577-t4w4pw12	72	18	-	-	HYPH
cord-260577-t4w4pw12	72	19	protein	protein	NN
cord-260577-t4w4pw12	72	20	expressing	express	VBG
cord-260577-t4w4pw12	72	21	cells	cell	NNS
cord-260577-t4w4pw12	72	22	into	into	IN
cord-260577-t4w4pw12	72	23	large	large	JJ
cord-260577-t4w4pw12	72	24	multinucleated	multinucleated	JJ
cord-260577-t4w4pw12	72	25	cells	cell	NNS
cord-260577-t4w4pw12	72	26	that	that	WDT
cord-260577-t4w4pw12	72	27	can	can	MD
cord-260577-t4w4pw12	72	28	be	be	VB
cord-260577-t4w4pw12	72	29	also	also	RB
cord-260577-t4w4pw12	72	30	seen	see	VBN
cord-260577-t4w4pw12	72	31	in	in	IN
cord-260577-t4w4pw12	72	32	'	'	``
cord-260577-t4w4pw12	72	33	real	real	JJ
cord-260577-t4w4pw12	72	34	'	'	''
cord-260577-t4w4pw12	72	35	SARS	SARS	NNP
cord-260577-t4w4pw12	72	36	infections	infection	NNS
cord-260577-t4w4pw12	72	37	.	.	.
cord-260577-t4w4pw12	73	1	Using	use	VBG
cord-260577-t4w4pw12	73	2	a	a	DT
cord-260577-t4w4pw12	73	3	mouse	mouse	NN
cord-260577-t4w4pw12	73	4	SARS	SARS	NNP
cord-260577-t4w4pw12	73	5	infection	infection	NN
cord-260577-t4w4pw12	73	6	model	model	NN
cord-260577-t4w4pw12	73	7	with	with	IN
cord-260577-t4w4pw12	73	8	ace2	ace2	CC
cord-260577-t4w4pw12	73	9	knockout	knockout	NN
cord-260577-t4w4pw12	73	10	mice	mouse	NNS
cord-260577-t4w4pw12	73	11	,	,	,
cord-260577-t4w4pw12	73	12	our	-PRON-	PRP$
cord-260577-t4w4pw12	73	13	group	group	NN
cord-260577-t4w4pw12	73	14	then	then	RB
cord-260577-t4w4pw12	73	15	provided	provide	VBD
cord-260577-t4w4pw12	73	16	evidence	evidence	NN
cord-260577-t4w4pw12	73	17	that	that	IN
cord-260577-t4w4pw12	73	18	ACE2	ACE2	NNP
cord-260577-t4w4pw12	73	19	is	be	VBZ
cord-260577-t4w4pw12	73	20	indeed	indeed	RB
cord-260577-t4w4pw12	73	21	essential	essential	JJ
cord-260577-t4w4pw12	73	22	for	for	IN
cord-260577-t4w4pw12	73	23	SARS	SARS	NNP
cord-260577-t4w4pw12	73	24	infections	infection	NNS
cord-260577-t4w4pw12	73	25	in	in	IN
cord-260577-t4w4pw12	73	26	vivo	vivo	NN
cord-260577-t4w4pw12	73	27	[	[	-LRB-
cord-260577-t4w4pw12	73	28	8	8	CD
cord-260577-t4w4pw12	73	29	]	]	-RRB-
cord-260577-t4w4pw12	73	30	.	.	.
cord-260577-t4w4pw12	74	1	When	when	WRB
cord-260577-t4w4pw12	74	2	ace2	ace2	NN
cord-260577-t4w4pw12	74	3	knockout	knockout	NN
cord-260577-t4w4pw12	74	4	mice	mouse	NNS
cord-260577-t4w4pw12	74	5	are	be	VBP
cord-260577-t4w4pw12	74	6	infected	infect	VBN
cord-260577-t4w4pw12	74	7	with	with	IN
cord-260577-t4w4pw12	74	8	the	the	DT
cord-260577-t4w4pw12	74	9	SARS	SARS	NNP
cord-260577-t4w4pw12	74	10	coronavirus	coronavirus	NN
cord-260577-t4w4pw12	74	11	,	,	,
cord-260577-t4w4pw12	74	12	they	-PRON-	PRP
cord-260577-t4w4pw12	74	13	were	be	VBD
cord-260577-t4w4pw12	74	14	resistant	resistant	JJ
cord-260577-t4w4pw12	74	15	to	to	IN
cord-260577-t4w4pw12	74	16	virus	virus	NN
cord-260577-t4w4pw12	74	17	infection	infection	NN
cord-260577-t4w4pw12	74	18	.	.	.
cord-260577-t4w4pw12	75	1	Virus	virus	NN
cord-260577-t4w4pw12	75	2	titers	titer	NNS
cord-260577-t4w4pw12	75	3	from	from	IN
cord-260577-t4w4pw12	75	4	the	the	DT
cord-260577-t4w4pw12	75	5	lung	lung	NN
cord-260577-t4w4pw12	75	6	tissues	tissue	NNS
cord-260577-t4w4pw12	75	7	of	of	IN
cord-260577-t4w4pw12	75	8	infected	infect	VBN
cord-260577-t4w4pw12	75	9	ace2	ace2	NNP
cord-260577-t4w4pw12	75	10	knockout	knockout	NN
cord-260577-t4w4pw12	75	11	mice	mouse	NNS
cord-260577-t4w4pw12	75	12	were	be	VBD
cord-260577-t4w4pw12	75	13	10	10	CD
cord-260577-t4w4pw12	75	14	5	5	CD
cord-260577-t4w4pw12	75	15	-fold	-fold	NN
cord-260577-t4w4pw12	75	16	lower	lower	RBR
cord-260577-t4w4pw12	75	17	than	than	IN
cord-260577-t4w4pw12	75	18	that	that	DT
cord-260577-t4w4pw12	75	19	isolated	isolate	VBN
cord-260577-t4w4pw12	75	20	from	from	IN
cord-260577-t4w4pw12	75	21	the	the	DT
cord-260577-t4w4pw12	75	22	lungs	lung	NNS
cord-260577-t4w4pw12	75	23	of	of	IN
cord-260577-t4w4pw12	75	24	SARS	SARS	NNP
cord-260577-t4w4pw12	75	25	-	-	HYPH
cord-260577-t4w4pw12	75	26	CoV	CoV	NNP
cord-260577-t4w4pw12	75	27	-	-	HYPH
cord-260577-t4w4pw12	75	28	infected	infect	VBN
cord-260577-t4w4pw12	75	29	wild	wild	JJ
cord-260577-t4w4pw12	75	30	type	type	NN
cord-260577-t4w4pw12	75	31	mice	mouse	NNS
cord-260577-t4w4pw12	75	32	.	.	.
cord-260577-t4w4pw12	76	1	Thus	thus	RB
cord-260577-t4w4pw12	76	2	,	,	,
cord-260577-t4w4pw12	76	3	without	without	IN
cord-260577-t4w4pw12	76	4	excluding	exclude	VBG
cord-260577-t4w4pw12	76	5	a	a	DT
cord-260577-t4w4pw12	76	6	second	second	JJ
cord-260577-t4w4pw12	76	7	functional	functional	JJ
cord-260577-t4w4pw12	76	8	SARS	SARS	NNP
cord-260577-t4w4pw12	76	9	-	-	HYPH
cord-260577-t4w4pw12	76	10	CoV	CoV	NNP
cord-260577-t4w4pw12	76	11	receptor	receptor	NN
cord-260577-t4w4pw12	76	12	,	,	,
cord-260577-t4w4pw12	76	13	ACE2	ACE2	NNP
cord-260577-t4w4pw12	76	14	is	be	VBZ
cord-260577-t4w4pw12	76	15	an	an	DT
cord-260577-t4w4pw12	76	16	essential	essential	JJ
cord-260577-t4w4pw12	76	17	receptor	receptor	NN
cord-260577-t4w4pw12	76	18	for	for	IN
cord-260577-t4w4pw12	76	19	SARS	SARS	NNP
cord-260577-t4w4pw12	76	20	infections	infection	NNS
cord-260577-t4w4pw12	76	21	in	in	IN
cord-260577-t4w4pw12	76	22	vivo	vivo	NN
cord-260577-t4w4pw12	76	23	.	.	.
cord-260577-t4w4pw12	77	1	Despite	despite	IN
cord-260577-t4w4pw12	77	2	many	many	JJ
cord-260577-t4w4pw12	77	3	studies	study	NNS
cord-260577-t4w4pw12	77	4	on	on	IN
cord-260577-t4w4pw12	77	5	SARS	SARS	NNP
cord-260577-t4w4pw12	77	6	-	-	HYPH
cord-260577-t4w4pw12	77	7	CoV	CoV	NNP
cord-260577-t4w4pw12	77	8	,	,	,
cord-260577-t4w4pw12	77	9	one	one	CD
cord-260577-t4w4pw12	77	10	mystery	mystery	NN
cord-260577-t4w4pw12	77	11	of	of	IN
cord-260577-t4w4pw12	77	12	SARS	SARS	NNP
cord-260577-t4w4pw12	77	13	-	-	HYPH
cord-260577-t4w4pw12	77	14	CoV	CoV	NNP
cord-260577-t4w4pw12	77	15	is	be	VBZ
cord-260577-t4w4pw12	77	16	why	why	WRB
cord-260577-t4w4pw12	77	17	,	,	,
cord-260577-t4w4pw12	77	18	in	in	IN
cord-260577-t4w4pw12	77	19	contrast	contrast	NN
cord-260577-t4w4pw12	77	20	to	to	IN
cord-260577-t4w4pw12	77	21	the	the	DT
cord-260577-t4w4pw12	77	22	other	other	JJ
cord-260577-t4w4pw12	77	23	coronaviruses	coronaviruse	NNS
cord-260577-t4w4pw12	77	24	,	,	,
cord-260577-t4w4pw12	77	25	infections	infection	NNS
cord-260577-t4w4pw12	77	26	with	with	IN
cord-260577-t4w4pw12	77	27	the	the	DT
cord-260577-t4w4pw12	77	28	SARS	SARS	NNP
cord-260577-t4w4pw12	77	29	-	-	HYPH
cord-260577-t4w4pw12	77	30	CoV	CoV	NNP
cord-260577-t4w4pw12	77	31	trigger	trigger	NN
cord-260577-t4w4pw12	77	32	severe	severe	JJ
cord-260577-t4w4pw12	77	33	lung	lung	NN
cord-260577-t4w4pw12	77	34	disease	disease	NN
cord-260577-t4w4pw12	77	35	with	with	IN
cord-260577-t4w4pw12	77	36	such	such	JJ
cord-260577-t4w4pw12	77	37	high	high	JJ
cord-260577-t4w4pw12	77	38	mortality	mortality	NN
cord-260577-t4w4pw12	77	39	.	.	.
cord-260577-t4w4pw12	78	1	Accumulating	accumulate	VBG
cord-260577-t4w4pw12	78	2	evidence	evidence	NN
cord-260577-t4w4pw12	78	3	further	further	RB
cord-260577-t4w4pw12	78	4	indicates	indicate	VBZ
cord-260577-t4w4pw12	78	5	that	that	IN
cord-260577-t4w4pw12	78	6	severe	severe	JJ
cord-260577-t4w4pw12	78	7	SARS	SARS	NNP
cord-260577-t4w4pw12	78	8	infections	infection	NNS
cord-260577-t4w4pw12	78	9	are	be	VBP
cord-260577-t4w4pw12	78	10	dependent	dependent	JJ
cord-260577-t4w4pw12	78	11	on	on	IN
cord-260577-t4w4pw12	78	12	the	the	DT
cord-260577-t4w4pw12	78	13	burden	burden	NN
cord-260577-t4w4pw12	78	14	of	of	IN
cord-260577-t4w4pw12	78	15	viral	viral	JJ
cord-260577-t4w4pw12	78	16	replication	replication	NN
cord-260577-t4w4pw12	78	17	as	as	RB
cord-260577-t4w4pw12	78	18	well	well	RB
cord-260577-t4w4pw12	78	19	as	as	IN
cord-260577-t4w4pw12	78	20	on	on	IN
cord-260577-t4w4pw12	78	21	the	the	DT
cord-260577-t4w4pw12	78	22	immunopathologic	immunopathologic	JJ
cord-260577-t4w4pw12	78	23	consequences	consequence	NNS
cord-260577-t4w4pw12	78	24	of	of	IN
cord-260577-t4w4pw12	78	25	the	the	DT
cord-260577-t4w4pw12	78	26	host	host	NN
cord-260577-t4w4pw12	78	27	response	response	NN
cord-260577-t4w4pw12	78	28	.	.	.
cord-260577-t4w4pw12	79	1	Our	-PRON-	PRP$
cord-260577-t4w4pw12	79	2	studies	study	NNS
cord-260577-t4w4pw12	79	3	have	have	VBP
cord-260577-t4w4pw12	79	4	implicated	implicate	VBN
cord-260577-t4w4pw12	79	5	the	the	DT
cord-260577-t4w4pw12	79	6	involvement	involvement	NN
cord-260577-t4w4pw12	79	7	of	of	IN
cord-260577-t4w4pw12	79	8	the	the	DT
cord-260577-t4w4pw12	79	9	RAS	RAS	NNP
cord-260577-t4w4pw12	79	10	in	in	IN
cord-260577-t4w4pw12	79	11	SARS	SARS	NNP
cord-260577-t4w4pw12	79	12	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	79	13	.	.	.
cord-260577-t4w4pw12	80	1	Intriguingly	intriguingly	RB
cord-260577-t4w4pw12	80	2	,	,	,
cord-260577-t4w4pw12	80	3	wild	wild	JJ
cord-260577-t4w4pw12	80	4	type	type	NN
cord-260577-t4w4pw12	80	5	mice	mouse	NNS
cord-260577-t4w4pw12	80	6	infected	infect	VBN
cord-260577-t4w4pw12	80	7	with	with	IN
cord-260577-t4w4pw12	80	8	SARS	SARS	NNP
cord-260577-t4w4pw12	80	9	-	-	HYPH
cord-260577-t4w4pw12	80	10	CoV	CoV	NNP
cord-260577-t4w4pw12	80	11	showed	show	VBD
cord-260577-t4w4pw12	80	12	markedly	markedly	RB
cord-260577-t4w4pw12	80	13	downregulated	downregulate	VBD
cord-260577-t4w4pw12	80	14	ACE2	ACE2	NNP
cord-260577-t4w4pw12	80	15	expression	expression	NN
cord-260577-t4w4pw12	80	16	in	in	IN
cord-260577-t4w4pw12	80	17	lungs	lung	NNS
cord-260577-t4w4pw12	80	18	.	.	.
cord-260577-t4w4pw12	81	1	Similarly	similarly	RB
cord-260577-t4w4pw12	81	2	,	,	,
cord-260577-t4w4pw12	81	3	treatment	treatment	NN
cord-260577-t4w4pw12	81	4	with	with	IN
cord-260577-t4w4pw12	81	5	recombinant	recombinant	JJ
cord-260577-t4w4pw12	81	6	SARS	SARS	NNP
cord-260577-t4w4pw12	81	7	-	-	HYPH
cord-260577-t4w4pw12	81	8	spike	spike	NN
cord-260577-t4w4pw12	81	9	protein	protein	NN
cord-260577-t4w4pw12	81	10	,	,	,
cord-260577-t4w4pw12	81	11	in	in	IN
cord-260577-t4w4pw12	81	12	the	the	DT
cord-260577-t4w4pw12	81	13	absence	absence	NN
cord-260577-t4w4pw12	81	14	of	of	IN
cord-260577-t4w4pw12	81	15	any	any	DT
cord-260577-t4w4pw12	81	16	other	other	JJ
cord-260577-t4w4pw12	81	17	virus	virus	NN
cord-260577-t4w4pw12	81	18	components	component	NNS
cord-260577-t4w4pw12	81	19	,	,	,
cord-260577-t4w4pw12	81	20	downregulates	downregulate	VBZ
cord-260577-t4w4pw12	81	21	ACE2	ACE2	NNP
cord-260577-t4w4pw12	81	22	expression	expression	NN
cord-260577-t4w4pw12	81	23	in	in	IN
cord-260577-t4w4pw12	81	24	vitro	vitro	FW
cord-260577-t4w4pw12	81	25	and	and	CC
cord-260577-t4w4pw12	81	26	in	in	IN
cord-260577-t4w4pw12	81	27	vivo	vivo	NNP
cord-260577-t4w4pw12	81	28	.	.	.
cord-260577-t4w4pw12	82	1	Thus	thus	RB
cord-260577-t4w4pw12	82	2	,	,	,
cord-260577-t4w4pw12	82	3	SARS	SARS	NNP
cord-260577-t4w4pw12	82	4	-	-	HYPH
cord-260577-t4w4pw12	82	5	CoV	CoV	NNP
cord-260577-t4w4pw12	82	6	-	-	HYPH
cord-260577-t4w4pw12	82	7	infected	infect	VBN
cord-260577-t4w4pw12	82	8	or	or	CC
cord-260577-t4w4pw12	82	9	spike	spike	NN
cord-260577-t4w4pw12	82	10	protein	protein	NN
cord-260577-t4w4pw12	82	11	-	-	HYPH
cord-260577-t4w4pw12	82	12	treated	treat	VBN
cord-260577-t4w4pw12	82	13	wild	wild	JJ
cord-260577-t4w4pw12	82	14	type	type	NN
cord-260577-t4w4pw12	82	15	mice	mouse	NNS
cord-260577-t4w4pw12	82	16	resemble	resemble	VBP
cord-260577-t4w4pw12	82	17	ace2	ace2	NN
cord-260577-t4w4pw12	82	18	knockout	knockout	NN
cord-260577-t4w4pw12	82	19	mice	mouse	NNS
cord-260577-t4w4pw12	82	20	,	,	,
cord-260577-t4w4pw12	82	21	and	and	CC
cord-260577-t4w4pw12	82	22	,	,	,
cord-260577-t4w4pw12	82	23	similar	similar	JJ
cord-260577-t4w4pw12	82	24	to	to	IN
cord-260577-t4w4pw12	82	25	ace2	ace2	NN
cord-260577-t4w4pw12	82	26	mutant	mutant	JJ
cord-260577-t4w4pw12	82	27	mice	mouse	NNS
cord-260577-t4w4pw12	82	28	,	,	,
cord-260577-t4w4pw12	82	29	spike	spike	NN
cord-260577-t4w4pw12	82	30	-	-	HYPH
cord-260577-t4w4pw12	82	31	treated	treat	VBN
cord-260577-t4w4pw12	82	32	wild	wild	JJ
cord-260577-t4w4pw12	82	33	type	type	NN
cord-260577-t4w4pw12	82	34	mice	mouse	NNS
cord-260577-t4w4pw12	82	35	show	show	VBP
cord-260577-t4w4pw12	82	36	markedly	markedly	RB
cord-260577-t4w4pw12	82	37	more	more	RBR
cord-260577-t4w4pw12	82	38	severe	severe	JJ
cord-260577-t4w4pw12	82	39	pathology	pathology	NN
cord-260577-t4w4pw12	82	40	in	in	IN
cord-260577-t4w4pw12	82	41	acute	acute	JJ
cord-260577-t4w4pw12	82	42	lung	lung	NN
cord-260577-t4w4pw12	82	43	injury	injury	NN
cord-260577-t4w4pw12	82	44	.	.	.
cord-260577-t4w4pw12	83	1	In	in	IN
cord-260577-t4w4pw12	83	2	addition	addition	NN
cord-260577-t4w4pw12	83	3	,	,	,
cord-260577-t4w4pw12	83	4	in	in	IN
cord-260577-t4w4pw12	83	5	spike	spike	NN
cord-260577-t4w4pw12	83	6	-	-	HYPH
cord-260577-t4w4pw12	83	7	treated	treat	VBN
cord-260577-t4w4pw12	83	8	mice	mouse	NNS
cord-260577-t4w4pw12	83	9	,	,	,
cord-260577-t4w4pw12	83	10	Ang	Ang	NNP
cord-260577-t4w4pw12	83	11	II	II	NNP
cord-260577-t4w4pw12	83	12	peptide	peptide	NN
cord-260577-t4w4pw12	83	13	levels	level	NNS
cord-260577-t4w4pw12	83	14	were	be	VBD
cord-260577-t4w4pw12	83	15	increased	increase	VBN
cord-260577-t4w4pw12	83	16	and	and	CC
cord-260577-t4w4pw12	83	17	the	the	DT
cord-260577-t4w4pw12	83	18	worsened	worsen	VBN
cord-260577-t4w4pw12	83	19	ARDS	ARDS	NNP
cord-260577-t4w4pw12	83	20	symptoms	symptom	NNS
cord-260577-t4w4pw12	83	21	could	could	MD
cord-260577-t4w4pw12	83	22	be	be	VB
cord-260577-t4w4pw12	83	23	partially	partially	RB
cord-260577-t4w4pw12	83	24	reversed	reverse	VBN
cord-260577-t4w4pw12	83	25	by	by	IN
cord-260577-t4w4pw12	83	26	AT	AT	NNP
cord-260577-t4w4pw12	83	27	1	1	CD
cord-260577-t4w4pw12	83	28	R	r	NN
cord-260577-t4w4pw12	83	29	blocker	blocker	NN
cord-260577-t4w4pw12	83	30	treatment	treatment	NN
cord-260577-t4w4pw12	83	31	.	.	.
cord-260577-t4w4pw12	84	1	Thus	thus	RB
cord-260577-t4w4pw12	84	2	,	,	,
cord-260577-t4w4pw12	84	3	the	the	DT
cord-260577-t4w4pw12	84	4	downregulation	downregulation	NN
cord-260577-t4w4pw12	84	5	of	of	IN
cord-260577-t4w4pw12	84	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	84	7	expression	expression	NN
cord-260577-t4w4pw12	84	8	in	in	IN
cord-260577-t4w4pw12	84	9	SARS	SARS	NNP
cord-260577-t4w4pw12	84	10	-	-	HYPH
cord-260577-t4w4pw12	84	11	CoV	CoV	NNP
cord-260577-t4w4pw12	84	12	infections	infection	NNS
cord-260577-t4w4pw12	84	13	might	may	MD
cord-260577-t4w4pw12	84	14	play	play	VB
cord-260577-t4w4pw12	84	15	a	a	DT
cord-260577-t4w4pw12	84	16	causal	causal	JJ
cord-260577-t4w4pw12	84	17	role	role	NN
cord-260577-t4w4pw12	84	18	in	in	IN
cord-260577-t4w4pw12	84	19	SARS	SARS	NNP
cord-260577-t4w4pw12	84	20	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	84	21	,	,	,
cord-260577-t4w4pw12	84	22	especially	especially	RB
cord-260577-t4w4pw12	84	23	in	in	IN
cord-260577-t4w4pw12	84	24	disease	disease	NN
cord-260577-t4w4pw12	84	25	progression	progression	NN
cord-260577-t4w4pw12	84	26	to	to	IN
cord-260577-t4w4pw12	84	27	ARDS	ARDS	NNP
cord-260577-t4w4pw12	84	28	.	.	.
cord-260577-t4w4pw12	85	1	Pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	85	2	circulation	circulation	NN
cord-260577-t4w4pw12	85	3	is	be	VBZ
cord-260577-t4w4pw12	85	4	a	a	DT
cord-260577-t4w4pw12	85	5	potentially	potentially	RB
cord-260577-t4w4pw12	85	6	important	important	JJ
cord-260577-t4w4pw12	85	7	target	target	NN
cord-260577-t4w4pw12	85	8	for	for	IN
cord-260577-t4w4pw12	85	9	the	the	DT
cord-260577-t4w4pw12	85	10	RAS	RAS	NNP
cord-260577-t4w4pw12	85	11	activation	activation	NN
cord-260577-t4w4pw12	85	12	in	in	IN
cord-260577-t4w4pw12	85	13	the	the	DT
cord-260577-t4w4pw12	85	14	lung	lung	NN
cord-260577-t4w4pw12	85	15	.	.	.
cord-260577-t4w4pw12	86	1	For	for	IN
cord-260577-t4w4pw12	86	2	instance	instance	NN
cord-260577-t4w4pw12	86	3	,	,	,
cord-260577-t4w4pw12	86	4	Ang	Ang	NNP
cord-260577-t4w4pw12	86	5	II	II	NNP
cord-260577-t4w4pw12	86	6	via	via	IN
cord-260577-t4w4pw12	86	7	its	-PRON-	PRP$
cord-260577-t4w4pw12	86	8	type	type	NN
cord-260577-t4w4pw12	86	9	1	1	CD
cord-260577-t4w4pw12	86	10	receptor	receptor	NN
cord-260577-t4w4pw12	86	11	(	(	-LRB-
cord-260577-t4w4pw12	86	12	AT	at	IN
cord-260577-t4w4pw12	86	13	1	1	CD
cord-260577-t4w4pw12	86	14	R	r	NN
cord-260577-t4w4pw12	86	15	)	)	-RRB-
cord-260577-t4w4pw12	86	16	induces	induce	VBZ
cord-260577-t4w4pw12	86	17	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	86	18	vasoconstriction	vasoconstriction	NN
cord-260577-t4w4pw12	86	19	in	in	IN
cord-260577-t4w4pw12	86	20	response	response	NN
cord-260577-t4w4pw12	86	21	to	to	IN
cord-260577-t4w4pw12	86	22	hypoxia	hypoxia	NN
cord-260577-t4w4pw12	86	23	,	,	,
cord-260577-t4w4pw12	86	24	suggesting	suggest	VBG
cord-260577-t4w4pw12	86	25	important	important	JJ
cord-260577-t4w4pw12	86	26	roles	role	NNS
cord-260577-t4w4pw12	86	27	of	of	IN
cord-260577-t4w4pw12	86	28	AT	at	NN
cord-260577-t4w4pw12	86	29	1	1	CD
cord-260577-t4w4pw12	86	30	R	r	NN
cord-260577-t4w4pw12	86	31	in	in	IN
cord-260577-t4w4pw12	86	32	elevating	elevate	VBG
cord-260577-t4w4pw12	86	33	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	86	34	vascular	vascular	JJ
cord-260577-t4w4pw12	86	35	tone	tone	NN
cord-260577-t4w4pw12	86	36	that	that	WDT
cord-260577-t4w4pw12	86	37	can	can	MD
cord-260577-t4w4pw12	86	38	result	result	VB
cord-260577-t4w4pw12	86	39	in	in	IN
cord-260577-t4w4pw12	86	40	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	86	41	edema	edema	NN
cord-260577-t4w4pw12	86	42	[	[	-LRB-
cord-260577-t4w4pw12	86	43	20	20	CD
cord-260577-t4w4pw12	86	44	]	]	-RRB-
cord-260577-t4w4pw12	86	45	.	.	.
cord-260577-t4w4pw12	87	1	Also	also	RB
cord-260577-t4w4pw12	87	2	,	,	,
cord-260577-t4w4pw12	87	3	infusion	infusion	NN
cord-260577-t4w4pw12	87	4	of	of	IN
cord-260577-t4w4pw12	87	5	Ang	Ang	NNP
cord-260577-t4w4pw12	87	6	I	I	NNP
cord-260577-t4w4pw12	87	7	[	[	-LRB-
cord-260577-t4w4pw12	87	8	21	21	CD
cord-260577-t4w4pw12	87	9	]	]	-RRB-
cord-260577-t4w4pw12	87	10	or	or	CC
cord-260577-t4w4pw12	87	11	Ang	Ang	NNP
cord-260577-t4w4pw12	87	12	II	II	NNP
cord-260577-t4w4pw12	87	13	[	[	-LRB-
cord-260577-t4w4pw12	87	14	22	22	CD
cord-260577-t4w4pw12	87	15	]	]	-RRB-
cord-260577-t4w4pw12	87	16	can	can	MD
cord-260577-t4w4pw12	87	17	produce	produce	VB
cord-260577-t4w4pw12	87	18	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	87	19	edema	edema	NN
cord-260577-t4w4pw12	87	20	independent	independent	JJ
cord-260577-t4w4pw12	87	21	of	of	IN
cord-260577-t4w4pw12	87	22	catecholamine	catecholamine	NN
cord-260577-t4w4pw12	87	23	release	release	NN
cord-260577-t4w4pw12	87	24	.	.	.
cord-260577-t4w4pw12	88	1	These	these	DT
cord-260577-t4w4pw12	88	2	data	datum	NNS
cord-260577-t4w4pw12	88	3	suggest	suggest	VBP
cord-260577-t4w4pw12	88	4	an	an	DT
cord-260577-t4w4pw12	88	5	important	important	JJ
cord-260577-t4w4pw12	88	6	role	role	NN
cord-260577-t4w4pw12	88	7	for	for	IN
cord-260577-t4w4pw12	88	8	the	the	DT
cord-260577-t4w4pw12	88	9	RAS	RAS	NNP
cord-260577-t4w4pw12	88	10	in	in	IN
cord-260577-t4w4pw12	88	11	regulating	regulate	VBG
cord-260577-t4w4pw12	88	12	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	88	13	vascular	vascular	JJ
cord-260577-t4w4pw12	88	14	tone	tone	NN
cord-260577-t4w4pw12	88	15	,	,	,
cord-260577-t4w4pw12	88	16	which	which	WDT
cord-260577-t4w4pw12	88	17	might	may	MD
cord-260577-t4w4pw12	88	18	also	also	RB
cord-260577-t4w4pw12	88	19	contribute	contribute	VB
cord-260577-t4w4pw12	88	20	to	to	IN
cord-260577-t4w4pw12	88	21	the	the	DT
cord-260577-t4w4pw12	88	22	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	88	23	of	of	IN
cord-260577-t4w4pw12	88	24	ARDS	ARDS	NNP
cord-260577-t4w4pw12	88	25	.	.	.
cord-260577-t4w4pw12	89	1	In	in	IN
cord-260577-t4w4pw12	89	2	addition	addition	NN
cord-260577-t4w4pw12	89	3	to	to	IN
cord-260577-t4w4pw12	89	4	increased	increase	VBN
cord-260577-t4w4pw12	89	5	vascular	vascular	JJ
cord-260577-t4w4pw12	89	6	tone	tone	NN
cord-260577-t4w4pw12	89	7	and	and	CC
cord-260577-t4w4pw12	89	8	a	a	DT
cord-260577-t4w4pw12	89	9	subsequent	subsequent	JJ
cord-260577-t4w4pw12	89	10	hydostatic	hydostatic	JJ
cord-260577-t4w4pw12	89	11	edema	edema	NN
cord-260577-t4w4pw12	89	12	formation	formation	NN
cord-260577-t4w4pw12	89	13	,	,	,
cord-260577-t4w4pw12	89	14	accumulating	accumulate	VBG
cord-260577-t4w4pw12	89	15	data	datum	NNS
cord-260577-t4w4pw12	89	16	suggest	suggest	VBP
cord-260577-t4w4pw12	89	17	that	that	IN
cord-260577-t4w4pw12	89	18	Ang	Ang	NNP
cord-260577-t4w4pw12	89	19	II	II	NNP
cord-260577-t4w4pw12	89	20	also	also	RB
cord-260577-t4w4pw12	89	21	increases	increase	VBZ
cord-260577-t4w4pw12	89	22	vascular	vascular	JJ
cord-260577-t4w4pw12	89	23	permeability	permeability	NN
cord-260577-t4w4pw12	89	24	via	via	IN
cord-260577-t4w4pw12	89	25	AT	at	IN
cord-260577-t4w4pw12	89	26	1	1	CD
cord-260577-t4w4pw12	89	27	R	r	NN
cord-260577-t4w4pw12	89	28	,	,	,
cord-260577-t4w4pw12	89	29	whereas	whereas	IN
cord-260577-t4w4pw12	89	30	stimulation	stimulation	NN
cord-260577-t4w4pw12	89	31	of	of	IN
cord-260577-t4w4pw12	89	32	AT	at	NN
cord-260577-t4w4pw12	89	33	2	2	CD
cord-260577-t4w4pw12	89	34	receptors	receptor	NNS
cord-260577-t4w4pw12	89	35	exerts	exert	VBZ
cord-260577-t4w4pw12	89	36	an	an	DT
cord-260577-t4w4pw12	89	37	opposite	opposite	JJ
cord-260577-t4w4pw12	89	38	effect	effect	NN
cord-260577-t4w4pw12	89	39	[	[	-LRB-
cord-260577-t4w4pw12	89	40	23	23	CD
cord-260577-t4w4pw12	89	41	]	]	-RRB-
cord-260577-t4w4pw12	89	42	.	.	.
cord-260577-t4w4pw12	90	1	Several	several	JJ
cord-260577-t4w4pw12	90	2	mediators	mediator	NNS
cord-260577-t4w4pw12	90	3	have	have	VBP
cord-260577-t4w4pw12	90	4	been	be	VBN
cord-260577-t4w4pw12	90	5	implicated	implicate	VBN
cord-260577-t4w4pw12	90	6	in	in	IN
cord-260577-t4w4pw12	90	7	Ang	Ang	NNP
cord-260577-t4w4pw12	90	8	II	II	NNP
cord-260577-t4w4pw12	90	9	regulated	regulate	VBD
cord-260577-t4w4pw12	90	10	vascular	vascular	JJ
cord-260577-t4w4pw12	90	11	permeability	permeability	NN
cord-260577-t4w4pw12	90	12	changes	change	NNS
cord-260577-t4w4pw12	90	13	,	,	,
cord-260577-t4w4pw12	90	14	including	include	VBG
cord-260577-t4w4pw12	90	15	eicosanoids	eicosanoid	NNS
cord-260577-t4w4pw12	90	16	(	(	-LRB-
cord-260577-t4w4pw12	90	17	i.e.	i.e.	FW
cord-260577-t4w4pw12	90	18	leukotriene	leukotriene	NNP
cord-260577-t4w4pw12	90	19	C	C	NNP
cord-260577-t4w4pw12	90	20	4	4	CD
cord-260577-t4w4pw12	90	21	,	,	,
cord-260577-t4w4pw12	90	22	prostaglandin	prostaglandin	NN
cord-260577-t4w4pw12	90	23	E	e	NN
cord-260577-t4w4pw12	90	24	2	2	CD
cord-260577-t4w4pw12	90	25	and	and	CC
cord-260577-t4w4pw12	90	26	I	-PRON-	PRP
cord-260577-t4w4pw12	90	27	2	2	CD
cord-260577-t4w4pw12	90	28	)	)	-RRB-
cord-260577-t4w4pw12	90	29	,	,	,
cord-260577-t4w4pw12	90	30	and	and	CC
cord-260577-t4w4pw12	90	31	vascular	vascular	JJ
cord-260577-t4w4pw12	90	32	permeability	permeability	NN
cord-260577-t4w4pw12	90	33	factor	factor	NN
cord-260577-t4w4pw12	90	34	.	.	.
cord-260577-t4w4pw12	91	1	However	however	RB
cord-260577-t4w4pw12	91	2	,	,	,
cord-260577-t4w4pw12	91	3	relatively	relatively	RB
cord-260577-t4w4pw12	91	4	few	few	JJ
cord-260577-t4w4pw12	91	5	studies	study	NNS
cord-260577-t4w4pw12	91	6	have	have	VBP
cord-260577-t4w4pw12	91	7	addressed	address	VBN
cord-260577-t4w4pw12	91	8	whether	whether	IN
cord-260577-t4w4pw12	91	9	the	the	DT
cord-260577-t4w4pw12	91	10	RAS	RAS	NNP
cord-260577-t4w4pw12	91	11	is	be	VBZ
cord-260577-t4w4pw12	91	12	involved	involve	VBN
cord-260577-t4w4pw12	91	13	in	in	IN
cord-260577-t4w4pw12	91	14	the	the	DT
cord-260577-t4w4pw12	91	15	increased	increased	JJ
cord-260577-t4w4pw12	91	16	vascular	vascular	JJ
cord-260577-t4w4pw12	91	17	permeability	permeability	NN
cord-260577-t4w4pw12	91	18	observed	observe	VBN
cord-260577-t4w4pw12	91	19	in	in	IN
cord-260577-t4w4pw12	91	20	ARDS	ARDS	NNP
cord-260577-t4w4pw12	91	21	.	.	.
cord-260577-t4w4pw12	92	1	Our	-PRON-	PRP$
cord-260577-t4w4pw12	92	2	study	study	NN
cord-260577-t4w4pw12	92	3	demonstrated	demonstrate	VBD
cord-260577-t4w4pw12	92	4	that	that	IN
cord-260577-t4w4pw12	92	5	loss	loss	NN
cord-260577-t4w4pw12	92	6	of	of	IN
cord-260577-t4w4pw12	92	7	ace2	ace2	NN
cord-260577-t4w4pw12	92	8	results	result	NNS
cord-260577-t4w4pw12	92	9	in	in	IN
cord-260577-t4w4pw12	92	10	increased	increase	VBN
cord-260577-t4w4pw12	92	11	vascular	vascular	JJ
cord-260577-t4w4pw12	92	12	permeability	permeability	NN
cord-260577-t4w4pw12	92	13	using	use	VBG
cord-260577-t4w4pw12	92	14	Evans	Evans	NNP
cord-260577-t4w4pw12	92	15	Vol	Vol	NNP
cord-260577-t4w4pw12	92	16	.	.	.
cord-260577-t4w4pw12	93	1	3	3	LS
cord-260577-t4w4pw12	93	2	,	,	,
cord-260577-t4w4pw12	93	3	No	no	UH
cord-260577-t4w4pw12	93	4	.	.	.
cord-260577-t4w4pw12	94	1	2	2	LS
cord-260577-t4w4pw12	94	2	2006	2006	CD
cord-260577-t4w4pw12	94	3	Drug	Drug	NNP
cord-260577-t4w4pw12	94	4	Discovery	Discovery	NNP
cord-260577-t4w4pw12	94	5	Today	Today	NNP
cord-260577-t4w4pw12	95	1	:	:	:
cord-260577-t4w4pw12	95	2	Disease	Disease	NNP
cord-260577-t4w4pw12	95	3	Mechanisms	Mechanisms	NNP
cord-260577-t4w4pw12	95	4	|	|	:
cord-260577-t4w4pw12	95	5	Immuno	Immuno	NNP
cord-260577-t4w4pw12	95	6	-	-	HYPH
cord-260577-t4w4pw12	95	7	disorders	disorder	NNS
cord-260577-t4w4pw12	95	8	and	and	CC
cord-260577-t4w4pw12	95	9	autoimmunity	autoimmunity	NN
cord-260577-t4w4pw12	95	10	Figure	figure	NN
cord-260577-t4w4pw12	95	11	2	2	CD
cord-260577-t4w4pw12	95	12	.	.	.
cord-260577-t4w4pw12	96	1	Schematic	schematic	JJ
cord-260577-t4w4pw12	96	2	diagram	diagram	NN
cord-260577-t4w4pw12	96	3	of	of	IN
cord-260577-t4w4pw12	96	4	the	the	DT
cord-260577-t4w4pw12	96	5	proposed	propose	VBN
cord-260577-t4w4pw12	96	6	role	role	NN
cord-260577-t4w4pw12	96	7	of	of	IN
cord-260577-t4w4pw12	96	8	the	the	DT
cord-260577-t4w4pw12	96	9	reninangiotensin	reninangiotensin	NNP
cord-260577-t4w4pw12	96	10	system	system	NN
cord-260577-t4w4pw12	96	11	in	in	IN
cord-260577-t4w4pw12	96	12	development	development	NN
cord-260577-t4w4pw12	96	13	of	of	IN
cord-260577-t4w4pw12	96	14	ARDS	ARDS	NNP
cord-260577-t4w4pw12	96	15	.	.	.
cord-260577-t4w4pw12	97	1	In	in	IN
cord-260577-t4w4pw12	97	2	ARDS	ARDS	NNP
cord-260577-t4w4pw12	97	3	induced	induce	VBN
cord-260577-t4w4pw12	97	4	by	by	IN
cord-260577-t4w4pw12	97	5	SARS	SARS	NNP
cord-260577-t4w4pw12	97	6	-	-	HYPH
cord-260577-t4w4pw12	97	7	CoV	CoV	NNP
cord-260577-t4w4pw12	97	8	infections	infection	NNS
cord-260577-t4w4pw12	97	9	,	,	,
cord-260577-t4w4pw12	97	10	acid	acid	JJ
cord-260577-t4w4pw12	97	11	aspiration	aspiration	NN
cord-260577-t4w4pw12	97	12	,	,	,
cord-260577-t4w4pw12	97	13	pneumonias	pneumonia	NNS
cord-260577-t4w4pw12	97	14	,	,	,
cord-260577-t4w4pw12	97	15	sepsis	sepsis	NN
cord-260577-t4w4pw12	97	16	or	or	CC
cord-260577-t4w4pw12	97	17	other	other	JJ
cord-260577-t4w4pw12	97	18	pathogenic	pathogenic	JJ
cord-260577-t4w4pw12	97	19	conditions	condition	NNS
cord-260577-t4w4pw12	97	20	,	,	,
cord-260577-t4w4pw12	97	21	the	the	DT
cord-260577-t4w4pw12	97	22	generation	generation	NN
cord-260577-t4w4pw12	97	23	of	of	IN
cord-260577-t4w4pw12	97	24	Ang	Ang	NNP
cord-260577-t4w4pw12	97	25	II	II	NNP
cord-260577-t4w4pw12	97	26	from	from	IN
cord-260577-t4w4pw12	97	27	Ang	Ang	NNP
cord-260577-t4w4pw12	97	28	I	-PRON-	PRP
cord-260577-t4w4pw12	97	29	is	be	VBZ
cord-260577-t4w4pw12	97	30	mediated	mediate	VBN
cord-260577-t4w4pw12	97	31	by	by	IN
cord-260577-t4w4pw12	97	32	ACE	ACE	NNP
cord-260577-t4w4pw12	97	33	.	.	.
cord-260577-t4w4pw12	98	1	Ang	Ang	NNP
cord-260577-t4w4pw12	98	2	II	II	NNP
cord-260577-t4w4pw12	98	3	contributes	contribute	VBZ
cord-260577-t4w4pw12	98	4	to	to	IN
cord-260577-t4w4pw12	98	5	acute	acute	JJ
cord-260577-t4w4pw12	98	6	lung	lung	NN
cord-260577-t4w4pw12	98	7	failure	failure	NN
cord-260577-t4w4pw12	98	8	through	through	IN
cord-260577-t4w4pw12	98	9	stimulation	stimulation	NN
cord-260577-t4w4pw12	98	10	of	of	IN
cord-260577-t4w4pw12	98	11	the	the	DT
cord-260577-t4w4pw12	98	12	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	98	13	II	II	NNP
cord-260577-t4w4pw12	98	14	type	type	NN
cord-260577-t4w4pw12	98	15	1	1	CD
cord-260577-t4w4pw12	98	16	receptor	receptor	NN
cord-260577-t4w4pw12	98	17	(	(	-LRB-
cord-260577-t4w4pw12	98	18	AT	at	IN
cord-260577-t4w4pw12	98	19	1	1	CD
cord-260577-t4w4pw12	98	20	R	r	NN
cord-260577-t4w4pw12	98	21	)	)	-RRB-
cord-260577-t4w4pw12	98	22	,	,	,
cord-260577-t4w4pw12	98	23	whereas	whereas	IN
cord-260577-t4w4pw12	98	24	ACE2	ACE2	NNP
cord-260577-t4w4pw12	98	25	and	and	CC
cord-260577-t4w4pw12	98	26	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	98	27	II	ii	CD
cord-260577-t4w4pw12	98	28	type	type	NN
cord-260577-t4w4pw12	98	29	2	2	CD
cord-260577-t4w4pw12	98	30	receptor	receptor	NN
cord-260577-t4w4pw12	98	31	(	(	-LRB-
cord-260577-t4w4pw12	98	32	AT	at	IN
cord-260577-t4w4pw12	98	33	2	2	CD
cord-260577-t4w4pw12	98	34	R	r	NN
cord-260577-t4w4pw12	98	35	)	)	-RRB-
cord-260577-t4w4pw12	98	36	negatively	negatively	RB
cord-260577-t4w4pw12	98	37	regulate	regulate	VB
cord-260577-t4w4pw12	98	38	this	this	DT
cord-260577-t4w4pw12	98	39	pathway	pathway	NN
cord-260577-t4w4pw12	98	40	and	and	CC
cord-260577-t4w4pw12	98	41	protect	protect	VB
cord-260577-t4w4pw12	98	42	from	from	IN
cord-260577-t4w4pw12	98	43	acute	acute	JJ
cord-260577-t4w4pw12	98	44	lung	lung	NN
cord-260577-t4w4pw12	98	45	failure	failure	NN
cord-260577-t4w4pw12	98	46	.	.	.
cord-260577-t4w4pw12	99	1	However	however	RB
cord-260577-t4w4pw12	99	2	,	,	,
cord-260577-t4w4pw12	99	3	additional	additional	JJ
cord-260577-t4w4pw12	99	4	ACE2regulated	ACE2regulated	NNP
cord-260577-t4w4pw12	99	5	,	,	,
cord-260577-t4w4pw12	99	6	but	but	CC
cord-260577-t4w4pw12	99	7	Ang	Ang	NNP
cord-260577-t4w4pw12	99	8	II	II	NNP
cord-260577-t4w4pw12	99	9	-	-	HYPH
cord-260577-t4w4pw12	99	10	independent	independent	JJ
cord-260577-t4w4pw12	99	11	pathways	pathway	NNS
cord-260577-t4w4pw12	99	12	seem	seem	VBP
cord-260577-t4w4pw12	99	13	to	to	TO
cord-260577-t4w4pw12	99	14	also	also	RB
cord-260577-t4w4pw12	99	15	contribute	contribute	VB
cord-260577-t4w4pw12	99	16	to	to	IN
cord-260577-t4w4pw12	99	17	ARDS	ARDS	NNP
cord-260577-t4w4pw12	99	18	.	.	.
cord-260577-t4w4pw12	100	1	www.drugdiscoverytoday.com	www.drugdiscoverytoday.com	ADD
cord-260577-t4w4pw12	101	1	Blue	blue	JJ
cord-260577-t4w4pw12	101	2	dye	dye	NN
cord-260577-t4w4pw12	101	3	injections	injection	NNS
cord-260577-t4w4pw12	101	4	as	as	IN
cord-260577-t4w4pw12	101	5	an	an	DT
cord-260577-t4w4pw12	101	6	in	in	IN
cord-260577-t4w4pw12	101	7	vivo	vivo	NN
cord-260577-t4w4pw12	101	8	indicator	indicator	NN
cord-260577-t4w4pw12	101	9	of	of	IN
cord-260577-t4w4pw12	101	10	albumin	albumin	NN
cord-260577-t4w4pw12	101	11	leakage	leakage	NN
cord-260577-t4w4pw12	101	12	in	in	IN
cord-260577-t4w4pw12	101	13	mice	mouse	NNS
cord-260577-t4w4pw12	101	14	.	.	.
cord-260577-t4w4pw12	102	1	This	this	DT
cord-260577-t4w4pw12	102	2	vascular	vascular	JJ
cord-260577-t4w4pw12	102	3	permeability	permeability	NN
cord-260577-t4w4pw12	102	4	was	be	VBD
cord-260577-t4w4pw12	102	5	significantly	significantly	RB
cord-260577-t4w4pw12	102	6	attenuated	attenuate	VBN
cord-260577-t4w4pw12	102	7	in	in	IN
cord-260577-t4w4pw12	102	8	the	the	DT
cord-260577-t4w4pw12	102	9	lungs	lung	NNS
cord-260577-t4w4pw12	102	10	of	of	IN
cord-260577-t4w4pw12	102	11	AT	AT	NNP
cord-260577-t4w4pw12	102	12	1	1	CD
cord-260577-t4w4pw12	102	13	R	r	NN
cord-260577-t4w4pw12	102	14	mutant	mutant	JJ
cord-260577-t4w4pw12	102	15	mice	mouse	NNS
cord-260577-t4w4pw12	102	16	.	.	.
cord-260577-t4w4pw12	103	1	These	these	DT
cord-260577-t4w4pw12	103	2	data	datum	NNS
cord-260577-t4w4pw12	103	3	indicate	indicate	VBP
cord-260577-t4w4pw12	103	4	that	that	IN
cord-260577-t4w4pw12	103	5	loss	loss	NN
cord-260577-t4w4pw12	103	6	of	of	IN
cord-260577-t4w4pw12	103	7	ACE2	ACE2	NNP
cord-260577-t4w4pw12	103	8	expression	expression	NN
cord-260577-t4w4pw12	103	9	and	and	CC
cord-260577-t4w4pw12	103	10	increased	increase	VBD
cord-260577-t4w4pw12	103	11	Ang	Ang	NNP
cord-260577-t4w4pw12	103	12	II	II	NNP
cord-260577-t4w4pw12	103	13	levels	level	NNS
cord-260577-t4w4pw12	103	14	can	can	MD
cord-260577-t4w4pw12	103	15	trigger	trigger	VB
cord-260577-t4w4pw12	103	16	leaky	leaky	JJ
cord-260577-t4w4pw12	103	17	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	103	18	blood	blood	NN
cord-260577-t4w4pw12	103	19	vessels	vessel	NNS
cord-260577-t4w4pw12	103	20	through	through	IN
cord-260577-t4w4pw12	103	21	AT	at	IN
cord-260577-t4w4pw12	103	22	1	1	CD
cord-260577-t4w4pw12	103	23	R	r	NN
cord-260577-t4w4pw12	103	24	stimulation	stimulation	NN
cord-260577-t4w4pw12	103	25	in	in	IN
cord-260577-t4w4pw12	103	26	ARDS	ARDS	NNP
cord-260577-t4w4pw12	103	27	[	[	-LRB-
cord-260577-t4w4pw12	103	28	7	7	CD
cord-260577-t4w4pw12	103	29	]	]	-RRB-
cord-260577-t4w4pw12	103	30	.	.	.
cord-260577-t4w4pw12	104	1	Both	both	CC
cord-260577-t4w4pw12	104	2	ACE	ACE	NNP
cord-260577-t4w4pw12	104	3	and	and	CC
cord-260577-t4w4pw12	104	4	ACE2	ACE2	NNP
cord-260577-t4w4pw12	104	5	are	be	VBP
cord-260577-t4w4pw12	104	6	unspecific	unspecific	JJ
cord-260577-t4w4pw12	104	7	proteases	protease	NNS
cord-260577-t4w4pw12	104	8	and	and	CC
cord-260577-t4w4pw12	104	9	can	can	MD
cord-260577-t4w4pw12	104	10	cleave	cleave	VB
cord-260577-t4w4pw12	104	11	additional	additional	JJ
cord-260577-t4w4pw12	104	12	substrates	substrate	NNS
cord-260577-t4w4pw12	104	13	that	that	WDT
cord-260577-t4w4pw12	104	14	might	may	MD
cord-260577-t4w4pw12	104	15	also	also	RB
cord-260577-t4w4pw12	104	16	play	play	VB
cord-260577-t4w4pw12	104	17	important	important	JJ
cord-260577-t4w4pw12	104	18	roles	role	NNS
cord-260577-t4w4pw12	104	19	in	in	IN
cord-260577-t4w4pw12	104	20	ACE	ACE	NNP
cord-260577-t4w4pw12	104	21	/	/	SYM
cord-260577-t4w4pw12	104	22	ACE2-regulated	ACE2-regulated	NNP
cord-260577-t4w4pw12	104	23	ARDS	ARDS	NNP
cord-260577-t4w4pw12	104	24	independent	independent	JJ
cord-260577-t4w4pw12	104	25	of	of	IN
cord-260577-t4w4pw12	104	26	Ang	Ang	NNP
cord-260577-t4w4pw12	104	27	II	II	NNP
cord-260577-t4w4pw12	104	28	.	.	.
cord-260577-t4w4pw12	105	1	One	one	CD
cord-260577-t4w4pw12	105	2	of	of	IN
cord-260577-t4w4pw12	105	3	the	the	DT
cord-260577-t4w4pw12	105	4	ACE	ACE	NNP
cord-260577-t4w4pw12	105	5	and	and	CC
cord-260577-t4w4pw12	105	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	105	7	targets	target	NNS
cord-260577-t4w4pw12	105	8	is	be	VBZ
cord-260577-t4w4pw12	105	9	bradykinin	bradykinin	JJ
cord-260577-t4w4pw12	105	10	and	and	CC
cord-260577-t4w4pw12	105	11	its	-PRON-	PRP$
cord-260577-t4w4pw12	105	12	peptide	peptide	NN
cord-260577-t4w4pw12	105	13	metabolites	metabolite	NNS
cord-260577-t4w4pw12	105	14	.	.	.
cord-260577-t4w4pw12	106	1	Bradykinin	bradykinin	NN
cord-260577-t4w4pw12	106	2	is	be	VBZ
cord-260577-t4w4pw12	106	3	the	the	DT
cord-260577-t4w4pw12	106	4	key	key	JJ
cord-260577-t4w4pw12	106	5	effecter	effecter	NN
cord-260577-t4w4pw12	106	6	in	in	IN
cord-260577-t4w4pw12	106	7	the	the	DT
cord-260577-t4w4pw12	106	8	kallikrein	kallikrein	NNP
cord-260577-t4w4pw12	106	9	-	-	HYPH
cord-260577-t4w4pw12	106	10	kinin	kinin	NNP
cord-260577-t4w4pw12	106	11	system	system	NN
cord-260577-t4w4pw12	106	12	and	and	CC
cord-260577-t4w4pw12	106	13	also	also	RB
cord-260577-t4w4pw12	106	14	functions	function	VBZ
cord-260577-t4w4pw12	106	15	as	as	IN
cord-260577-t4w4pw12	106	16	a	a	DT
cord-260577-t4w4pw12	106	17	major	major	JJ
cord-260577-t4w4pw12	106	18	proinflammatory	proinflammatory	JJ
cord-260577-t4w4pw12	106	19	mediator	mediator	NN
cord-260577-t4w4pw12	106	20	.	.	.
cord-260577-t4w4pw12	107	1	Bradykinin	bradykinin	NN
cord-260577-t4w4pw12	107	2	is	be	VBZ
cord-260577-t4w4pw12	107	3	degraded	degrade	VBN
cord-260577-t4w4pw12	107	4	by	by	IN
cord-260577-t4w4pw12	107	5	two	two	CD
cord-260577-t4w4pw12	107	6	main	main	JJ
cord-260577-t4w4pw12	107	7	kinases	kinase	NNS
cord-260577-t4w4pw12	107	8	,	,	,
cord-260577-t4w4pw12	107	9	which	which	WDT
cord-260577-t4w4pw12	107	10	are	be	VBP
cord-260577-t4w4pw12	107	11	ACE	ACE	NNP
cord-260577-t4w4pw12	107	12	(	(	-LRB-
cord-260577-t4w4pw12	107	13	also	also	RB
cord-260577-t4w4pw12	107	14	known	know	VBN
cord-260577-t4w4pw12	107	15	as	as	IN
cord-260577-t4w4pw12	107	16	kinase	kinase	NNP
cord-260577-t4w4pw12	107	17	II	II	NNP
cord-260577-t4w4pw12	107	18	in	in	IN
cord-260577-t4w4pw12	107	19	this	this	DT
cord-260577-t4w4pw12	107	20	system	system	NN
cord-260577-t4w4pw12	107	21	)	)	-RRB-
cord-260577-t4w4pw12	107	22	and	and	CC
cord-260577-t4w4pw12	107	23	neutral	neutral	JJ
cord-260577-t4w4pw12	107	24	endopeptidase	endopeptidase	NN
cord-260577-t4w4pw12	107	25	.	.	.
cord-260577-t4w4pw12	108	1	The	the	DT
cord-260577-t4w4pw12	108	2	biological	biological	JJ
cord-260577-t4w4pw12	108	3	effects	effect	NNS
cord-260577-t4w4pw12	108	4	of	of	IN
cord-260577-t4w4pw12	108	5	bradykinin	bradykinin	NN
cord-260577-t4w4pw12	108	6	are	be	VBP
cord-260577-t4w4pw12	108	7	mediated	mediate	VBN
cord-260577-t4w4pw12	108	8	by	by	IN
cord-260577-t4w4pw12	108	9	B1	b1	NN
cord-260577-t4w4pw12	108	10	receptor	receptor	NN
cord-260577-t4w4pw12	108	11	(	(	-LRB-
cord-260577-t4w4pw12	108	12	B	b	NN
cord-260577-t4w4pw12	108	13	1	1	CD
cord-260577-t4w4pw12	108	14	R	r	NN
cord-260577-t4w4pw12	108	15	)	)	-RRB-
cord-260577-t4w4pw12	108	16	and	and	CC
cord-260577-t4w4pw12	108	17	B2	b2	NN
cord-260577-t4w4pw12	108	18	receptor	receptor	NN
cord-260577-t4w4pw12	108	19	(	(	-LRB-
cord-260577-t4w4pw12	108	20	B	b	NN
cord-260577-t4w4pw12	108	21	2	2	CD
cord-260577-t4w4pw12	108	22	R	r	NN
cord-260577-t4w4pw12	108	23	)	)	-RRB-
cord-260577-t4w4pw12	108	24	.	.	.
cord-260577-t4w4pw12	109	1	B	b	NN
cord-260577-t4w4pw12	109	2	2	2	CD
cord-260577-t4w4pw12	109	3	R	r	NN
cord-260577-t4w4pw12	109	4	mediate	mediate	VB
cord-260577-t4w4pw12	109	5	most	most	JJS
cord-260577-t4w4pw12	109	6	the	the	DT
cord-260577-t4w4pw12	109	7	known	know	VBN
cord-260577-t4w4pw12	109	8	effects	effect	NNS
cord-260577-t4w4pw12	109	9	of	of	IN
cord-260577-t4w4pw12	109	10	bradykinin	bradykinin	NN
cord-260577-t4w4pw12	109	11	,	,	,
cord-260577-t4w4pw12	109	12	including	include	VBG
cord-260577-t4w4pw12	109	13	antiproliferative	antiproliferative	JJ
cord-260577-t4w4pw12	109	14	,	,	,
cord-260577-t4w4pw12	109	15	antioxidant	antioxidant	JJ
cord-260577-t4w4pw12	109	16	and	and	CC
cord-260577-t4w4pw12	109	17	antithrombotic	antithrombotic	JJ
cord-260577-t4w4pw12	109	18	effects	effect	NNS
cord-260577-t4w4pw12	109	19	[	[	-LRB-
cord-260577-t4w4pw12	109	20	24	24	CD
cord-260577-t4w4pw12	109	21	]	]	-RRB-
cord-260577-t4w4pw12	109	22	.	.	.
cord-260577-t4w4pw12	110	1	The	the	DT
cord-260577-t4w4pw12	110	2	in	in	IN
cord-260577-t4w4pw12	110	3	vivo	vivo	NN
cord-260577-t4w4pw12	110	4	effects	effect	NNS
cord-260577-t4w4pw12	110	5	mediated	mediate	VBN
cord-260577-t4w4pw12	110	6	via	via	IN
cord-260577-t4w4pw12	110	7	B	b	NN
cord-260577-t4w4pw12	110	8	1	1	CD
cord-260577-t4w4pw12	110	9	R	r	NN
cord-260577-t4w4pw12	110	10	or	or	CC
cord-260577-t4w4pw12	110	11	B	b	NN
cord-260577-t4w4pw12	110	12	2	2	CD
cord-260577-t4w4pw12	110	13	R	r	NN
cord-260577-t4w4pw12	110	14	are	be	VBP
cord-260577-t4w4pw12	110	15	still	still	RB
cord-260577-t4w4pw12	110	16	poorly	poorly	RB
cord-260577-t4w4pw12	110	17	characterized	characterize	VBN
cord-260577-t4w4pw12	110	18	.	.	.
cord-260577-t4w4pw12	111	1	A	a	DT
cord-260577-t4w4pw12	111	2	recent	recent	JJ
cord-260577-t4w4pw12	111	3	study	study	NN
cord-260577-t4w4pw12	111	4	suggests	suggest	VBZ
cord-260577-t4w4pw12	111	5	that	that	IN
cord-260577-t4w4pw12	111	6	expression	expression	NN
cord-260577-t4w4pw12	111	7	of	of	IN
cord-260577-t4w4pw12	111	8	B	b	NN
cord-260577-t4w4pw12	111	9	1	1	CD
cord-260577-t4w4pw12	111	10	R	r	NN
cord-260577-t4w4pw12	111	11	is	be	VBZ
cord-260577-t4w4pw12	111	12	induced	induce	VBN
cord-260577-t4w4pw12	111	13	by	by	IN
cord-260577-t4w4pw12	111	14	cytokines	cytokine	NNS
cord-260577-t4w4pw12	111	15	during	during	IN
cord-260577-t4w4pw12	111	16	inflammation	inflammation	NN
cord-260577-t4w4pw12	111	17	in	in	IN
cord-260577-t4w4pw12	111	18	rats	rat	NNS
cord-260577-t4w4pw12	111	19	[	[	-LRB-
cord-260577-t4w4pw12	111	20	25	25	CD
cord-260577-t4w4pw12	111	21	]	]	-RRB-
cord-260577-t4w4pw12	111	22	,	,	,
cord-260577-t4w4pw12	111	23	albeit	albeit	IN
cord-260577-t4w4pw12	111	24	the	the	DT
cord-260577-t4w4pw12	111	25	role	role	NN
cord-260577-t4w4pw12	111	26	of	of	IN
cord-260577-t4w4pw12	111	27	bradykinin	bradykinin	NN
cord-260577-t4w4pw12	111	28	in	in	IN
cord-260577-t4w4pw12	111	29	Ang	Ang	NNP
cord-260577-t4w4pw12	111	30	II	II	NNP
cord-260577-t4w4pw12	111	31	-	-	HYPH
cord-260577-t4w4pw12	111	32	induced	induce	VBN
cord-260577-t4w4pw12	111	33	inflammation	inflammation	NN
cord-260577-t4w4pw12	111	34	remains	remain	VBZ
cord-260577-t4w4pw12	111	35	unclear	unclear	JJ
cord-260577-t4w4pw12	111	36	.	.	.
cord-260577-t4w4pw12	112	1	ACE2	ACE2	NNP
cord-260577-t4w4pw12	112	2	can	can	MD
cord-260577-t4w4pw12	112	3	remove	remove	VB
cord-260577-t4w4pw12	112	4	in	in	RP
cord-260577-t4w4pw12	112	5	in	in	IN
cord-260577-t4w4pw12	112	6	vitro	vitro	FW
cord-260577-t4w4pw12	113	1	assays	assays	NNP
cord-260577-t4w4pw12	113	2	the	the	DT
cord-260577-t4w4pw12	113	3	C	C	NNP
cord-260577-t4w4pw12	113	4	-	-	HYPH
cord-260577-t4w4pw12	113	5	terminal	terminal	NN
cord-260577-t4w4pw12	113	6	residue	residue	NN
cord-260577-t4w4pw12	113	7	from	from	IN
cord-260577-t4w4pw12	113	8	apelin	apelin	NNP
cord-260577-t4w4pw12	113	9	and	and	CC
cord-260577-t4w4pw12	113	10	other	other	JJ
cord-260577-t4w4pw12	113	11	vasoactive	vasoactive	JJ
cord-260577-t4w4pw12	113	12	peptides	peptide	NNS
cord-260577-t4w4pw12	113	13	such	such	JJ
cord-260577-t4w4pw12	113	14	as	as	IN
cord-260577-t4w4pw12	113	15	neurotensin	neurotensin	NNP
cord-260577-t4w4pw12	113	16	and	and	CC
cord-260577-t4w4pw12	113	17	neurotensin	neurotensin	NN
cord-260577-t4w4pw12	113	18	-	-	HYPH
cord-260577-t4w4pw12	113	19	related	relate	VBN
cord-260577-t4w4pw12	113	20	peptide	peptide	NN
cord-260577-t4w4pw12	113	21	kinetensin	kinetensin	NN
cord-260577-t4w4pw12	113	22	.	.	.
cord-260577-t4w4pw12	114	1	Moreover	moreover	RB
cord-260577-t4w4pw12	114	2	,	,	,
cord-260577-t4w4pw12	114	3	the	the	DT
cord-260577-t4w4pw12	114	4	opioid	opioid	JJ
cord-260577-t4w4pw12	114	5	peptides	peptide	NNS
cord-260577-t4w4pw12	114	6	dynorphin	dynorphin	NNP
cord-260577-t4w4pw12	115	1	A	a	DT
cord-260577-t4w4pw12	115	2	(	(	-LRB-
cord-260577-t4w4pw12	115	3	1	1	CD
cord-260577-t4w4pw12	115	4	-	-	SYM
cord-260577-t4w4pw12	115	5	13	13	CD
cord-260577-t4w4pw12	115	6	)	)	-RRB-
cord-260577-t4w4pw12	115	7	and	and	CC
cord-260577-t4w4pw12	116	1	b	b	LS
cord-260577-t4w4pw12	116	2	-	-	:
cord-260577-t4w4pw12	116	3	casamorphin	casamorphin	NNP
cord-260577-t4w4pw12	116	4	are	be	VBP
cord-260577-t4w4pw12	116	5	also	also	RB
cord-260577-t4w4pw12	116	6	substrates	substrate	NNS
cord-260577-t4w4pw12	116	7	of	of	IN
cord-260577-t4w4pw12	116	8	ACE2	ACE2	NNP
cord-260577-t4w4pw12	116	9	.	.	.
cord-260577-t4w4pw12	117	1	In	in	IN
cord-260577-t4w4pw12	117	2	contrast	contrast	NN
cord-260577-t4w4pw12	117	3	to	to	IN
cord-260577-t4w4pw12	117	4	ACE	ACE	NNP
cord-260577-t4w4pw12	117	5	,	,	,
cord-260577-t4w4pw12	117	6	ACE2	ACE2	NNP
cord-260577-t4w4pw12	117	7	does	do	VBZ
cord-260577-t4w4pw12	117	8	not	not	RB
cord-260577-t4w4pw12	117	9	metabolize	metabolize	VB
cord-260577-t4w4pw12	117	10	bradykinin	bradykinin	NN
cord-260577-t4w4pw12	117	11	,	,	,
cord-260577-t4w4pw12	117	12	but	but	CC
cord-260577-t4w4pw12	117	13	catalytically	catalytically	RB
cord-260577-t4w4pw12	117	14	inactivates	inactivate	VBZ
cord-260577-t4w4pw12	117	15	both	both	DT
cord-260577-t4w4pw12	117	16	[	[	-LRB-
cord-260577-t4w4pw12	117	17	des	des	FW
cord-260577-t4w4pw12	117	18	-	-	HYPH
cord-260577-t4w4pw12	117	19	Arg	Arg	NNP
cord-260577-t4w4pw12	117	20	9	9	CD
cord-260577-t4w4pw12	117	21	]	]	-RRB-
cord-260577-t4w4pw12	117	22	-bradykinin	-bradykinin	.
cord-260577-t4w4pw12	118	1	and	and	CC
cord-260577-t4w4pw12	118	2	lys[des	lys[des	NNP
cord-260577-t4w4pw12	118	3	-	-	HYPH
cord-260577-t4w4pw12	118	4	Arg	arg	NN
cord-260577-t4w4pw12	118	5	9	9	CD
cord-260577-t4w4pw12	118	6	]	]	-RRB-
cord-260577-t4w4pw12	118	7	-bradykinin	-bradykinin	.
cord-260577-t4w4pw12	119	1	[	[	-LRB-
cord-260577-t4w4pw12	119	2	3	3	CD
cord-260577-t4w4pw12	119	3	,	,	,
cord-260577-t4w4pw12	119	4	26	26	CD
cord-260577-t4w4pw12	119	5	]	]	-RRB-
cord-260577-t4w4pw12	119	6	.	.	.
cord-260577-t4w4pw12	120	1	Thus	thus	RB
cord-260577-t4w4pw12	120	2	,	,	,
cord-260577-t4w4pw12	120	3	although	although	IN
cord-260577-t4w4pw12	120	4	many	many	JJ
cord-260577-t4w4pw12	120	5	ACE2	ACE2	NNP
cord-260577-t4w4pw12	120	6	functions	function	NNS
cord-260577-t4w4pw12	120	7	have	have	VBP
cord-260577-t4w4pw12	120	8	been	be	VBN
cord-260577-t4w4pw12	120	9	attributed	attribute	VBN
cord-260577-t4w4pw12	120	10	to	to	IN
cord-260577-t4w4pw12	120	11	the	the	DT
cord-260577-t4w4pw12	120	12	regulation	regulation	NN
cord-260577-t4w4pw12	120	13	of	of	IN
cord-260577-t4w4pw12	120	14	Ang	Ang	NNP
cord-260577-t4w4pw12	120	15	II	II	NNP
cord-260577-t4w4pw12	120	16	levels	level	NNS
cord-260577-t4w4pw12	120	17	,	,	,
cord-260577-t4w4pw12	120	18	Ang	Ang	NNP
cord-260577-t4w4pw12	120	19	II	II	NNP
cord-260577-t4w4pw12	120	20	itself	-PRON-	PRP
cord-260577-t4w4pw12	120	21	is	be	VBZ
cord-260577-t4w4pw12	120	22	probably	probably	RB
cord-260577-t4w4pw12	120	23	only	only	RB
cord-260577-t4w4pw12	120	24	part	part	NN
cord-260577-t4w4pw12	120	25	of	of	IN
cord-260577-t4w4pw12	120	26	the	the	DT
cord-260577-t4w4pw12	120	27	ACE2	ACE2	NNP
cord-260577-t4w4pw12	120	28	story	story	NN
cord-260577-t4w4pw12	120	29	and	and	CC
cord-260577-t4w4pw12	120	30	other	other	JJ
cord-260577-t4w4pw12	120	31	ACE2	ACE2	NNP
cord-260577-t4w4pw12	120	32	substrates	substrate	NNS
cord-260577-t4w4pw12	120	33	might	may	MD
cord-260577-t4w4pw12	120	34	play	play	VB
cord-260577-t4w4pw12	120	35	a	a	DT
cord-260577-t4w4pw12	120	36	major	major	JJ
cord-260577-t4w4pw12	120	37	role	role	NN
cord-260577-t4w4pw12	120	38	in	in	IN
cord-260577-t4w4pw12	120	39	understanding	understand	VBG
cord-260577-t4w4pw12	120	40	ACE2	ACE2	NNP
cord-260577-t4w4pw12	120	41	functions	function	NNS
cord-260577-t4w4pw12	120	42	.	.	.
cord-260577-t4w4pw12	121	1	Importantly	importantly	RB
cord-260577-t4w4pw12	121	2	,	,	,
cord-260577-t4w4pw12	121	3	our	-PRON-	PRP$
cord-260577-t4w4pw12	121	4	own	own	JJ
cord-260577-t4w4pw12	121	5	preliminary	preliminary	JJ
cord-260577-t4w4pw12	121	6	results	result	NNS
cord-260577-t4w4pw12	121	7	suggest	suggest	VBP
cord-260577-t4w4pw12	121	8	that	that	IN
cord-260577-t4w4pw12	121	9	inhibition	inhibition	NN
cord-260577-t4w4pw12	121	10	of	of	IN
cord-260577-t4w4pw12	121	11	the	the	DT
cord-260577-t4w4pw12	121	12	bradykinin	bradykinin	NN
cord-260577-t4w4pw12	121	13	receptor	receptor	NN
cord-260577-t4w4pw12	121	14	can	can	MD
cord-260577-t4w4pw12	121	15	also	also	RB
cord-260577-t4w4pw12	121	16	alleviate	alleviate	VB
cord-260577-t4w4pw12	121	17	ARDS	ARDS	NNP
cord-260577-t4w4pw12	121	18	(	(	-LRB-
cord-260577-t4w4pw12	121	19	Y.I.	Y.I.	NNP
cord-260577-t4w4pw12	121	20	and	and	CC
cord-260577-t4w4pw12	121	21	J.M.P.	J.M.P.	NNP
cord-260577-t4w4pw12	121	22	,	,	,
cord-260577-t4w4pw12	121	23	unpublished	unpublished	JJ
cord-260577-t4w4pw12	121	24	)	)	-RRB-
cord-260577-t4w4pw12	121	25	.	.	.
cord-260577-t4w4pw12	122	1	Recently	recently	RB
cord-260577-t4w4pw12	122	2	,	,	,
cord-260577-t4w4pw12	122	3	the	the	DT
cord-260577-t4w4pw12	122	4	critical	critical	JJ
cord-260577-t4w4pw12	122	5	importance	importance	NN
cord-260577-t4w4pw12	122	6	of	of	IN
cord-260577-t4w4pw12	122	7	RAS	RAS	NNP
cord-260577-t4w4pw12	122	8	in	in	IN
cord-260577-t4w4pw12	122	9	the	the	DT
cord-260577-t4w4pw12	122	10	pathogenesis	pathogenesis	NN
cord-260577-t4w4pw12	122	11	of	of	IN
cord-260577-t4w4pw12	122	12	ARDS	ARDS	NNP
cord-260577-t4w4pw12	122	13	has	have	VBZ
cord-260577-t4w4pw12	122	14	been	be	VBN
cord-260577-t4w4pw12	122	15	established	establish	VBN
cord-260577-t4w4pw12	122	16	in	in	IN
cord-260577-t4w4pw12	122	17	genetic	genetic	JJ
cord-260577-t4w4pw12	122	18	animal	animal	NN
cord-260577-t4w4pw12	122	19	models	model	NNS
cord-260577-t4w4pw12	122	20	.	.	.
cord-260577-t4w4pw12	123	1	ACE2	ACE2	NNP
cord-260577-t4w4pw12	123	2	protects	protect	VBZ
cord-260577-t4w4pw12	123	3	murine	murine	JJ
cord-260577-t4w4pw12	123	4	lungs	lung	NNS
cord-260577-t4w4pw12	123	5	from	from	IN
cord-260577-t4w4pw12	123	6	acute	acute	JJ
cord-260577-t4w4pw12	123	7	lung	lung	NN
cord-260577-t4w4pw12	123	8	injury	injury	NN
cord-260577-t4w4pw12	123	9	induced	induce	VBN
cord-260577-t4w4pw12	123	10	by	by	IN
cord-260577-t4w4pw12	123	11	acid	acid	JJ
cord-260577-t4w4pw12	123	12	aspiration	aspiration	NN
cord-260577-t4w4pw12	123	13	,	,	,
cord-260577-t4w4pw12	123	14	endotoxin	endotoxin	NN
cord-260577-t4w4pw12	123	15	shock	shock	NN
cord-260577-t4w4pw12	123	16	and	and	CC
cord-260577-t4w4pw12	123	17	peritoneal	peritoneal	NN
cord-260577-t4w4pw12	123	18	sepsis	sepsis	NN
cord-260577-t4w4pw12	123	19	[	[	-LRB-
cord-260577-t4w4pw12	123	20	7	7	CD
cord-260577-t4w4pw12	123	21	]	]	-RRB-
cord-260577-t4w4pw12	123	22	.	.	.
cord-260577-t4w4pw12	124	1	In	in	IN
cord-260577-t4w4pw12	124	2	addition	addition	NN
cord-260577-t4w4pw12	124	3	,	,	,
cord-260577-t4w4pw12	124	4	ace	ace	NN
cord-260577-t4w4pw12	124	5	knockout	knockout	NN
cord-260577-t4w4pw12	124	6	mice	mouse	NNS
cord-260577-t4w4pw12	124	7	and	and	CC
cord-260577-t4w4pw12	124	8	AT	at	IN
cord-260577-t4w4pw12	124	9	1	1	CD
cord-260577-t4w4pw12	124	10	R	r	NN
cord-260577-t4w4pw12	124	11	knockout	knockout	NN
cord-260577-t4w4pw12	124	12	mice	mouse	NNS
cord-260577-t4w4pw12	124	13	,	,	,
cord-260577-t4w4pw12	124	14	but	but	CC
cord-260577-t4w4pw12	124	15	not	not	RB
cord-260577-t4w4pw12	124	16	AT	at	IN
cord-260577-t4w4pw12	124	17	2	2	CD
cord-260577-t4w4pw12	124	18	R	r	NN
cord-260577-t4w4pw12	124	19	knockout	knockout	NN
cord-260577-t4w4pw12	124	20	mice	mouse	NNS
cord-260577-t4w4pw12	124	21	,	,	,
cord-260577-t4w4pw12	124	22	showed	show	VBD
cord-260577-t4w4pw12	124	23	improved	improved	JJ
cord-260577-t4w4pw12	124	24	symptoms	symptom	NNS
cord-260577-t4w4pw12	124	25	of	of	IN
cord-260577-t4w4pw12	124	26	acute	acute	JJ
cord-260577-t4w4pw12	124	27	lung	lung	NN
cord-260577-t4w4pw12	124	28	injury	injury	NN
cord-260577-t4w4pw12	124	29	[	[	-LRB-
cord-260577-t4w4pw12	124	30	7	7	CD
cord-260577-t4w4pw12	124	31	]	]	-RRB-
cord-260577-t4w4pw12	124	32	,	,	,
cord-260577-t4w4pw12	124	33	consistent	consistent	JJ
cord-260577-t4w4pw12	124	34	with	with	IN
cord-260577-t4w4pw12	124	35	other	other	JJ
cord-260577-t4w4pw12	124	36	experimental	experimental	JJ
cord-260577-t4w4pw12	124	37	studies	study	NNS
cord-260577-t4w4pw12	124	38	[	[	-LRB-
cord-260577-t4w4pw12	124	39	17	17	CD
cord-260577-t4w4pw12	124	40	,	,	,
cord-260577-t4w4pw12	124	41	27	27	CD
cord-260577-t4w4pw12	124	42	,	,	,
cord-260577-t4w4pw12	124	43	28	28	CD
cord-260577-t4w4pw12	124	44	]	]	-RRB-
cord-260577-t4w4pw12	124	45	.	.	.
cord-260577-t4w4pw12	125	1	Also	also	RB
cord-260577-t4w4pw12	125	2	,	,	,
cord-260577-t4w4pw12	125	3	ACE2	ACE2	NNP
cord-260577-t4w4pw12	125	4	has	have	VBZ
cord-260577-t4w4pw12	125	5	been	be	VBN
cord-260577-t4w4pw12	125	6	identified	identify	VBN
cord-260577-t4w4pw12	125	7	as	as	IN
cord-260577-t4w4pw12	125	8	a	a	DT
cord-260577-t4w4pw12	125	9	key	key	JJ
cord-260577-t4w4pw12	125	10	SARS	SARS	NNP
cord-260577-t4w4pw12	125	11	-	-	HYPH
cord-260577-t4w4pw12	125	12	CoV	CoV	NNP
cord-260577-t4w4pw12	125	13	receptor	receptor	NN
cord-260577-t4w4pw12	125	14	[	[	-LRB-
cord-260577-t4w4pw12	125	15	5	5	CD
cord-260577-t4w4pw12	125	16	,	,	,
cord-260577-t4w4pw12	125	17	8	8	CD
cord-260577-t4w4pw12	125	18	]	]	-RRB-
cord-260577-t4w4pw12	125	19	and	and	CC
cord-260577-t4w4pw12	125	20	importantly	importantly	RB
cord-260577-t4w4pw12	125	21	,	,	,
cord-260577-t4w4pw12	125	22	ACE2	ACE2	NNP
cord-260577-t4w4pw12	125	23	plays	play	VBZ
cord-260577-t4w4pw12	125	24	a	a	DT
cord-260577-t4w4pw12	125	25	protective	protective	JJ
cord-260577-t4w4pw12	125	26	role	role	NN
cord-260577-t4w4pw12	125	27	in	in	IN
cord-260577-t4w4pw12	125	28	SARS	SARS	NNP
cord-260577-t4w4pw12	125	29	-	-	HYPH
cord-260577-t4w4pw12	125	30	CoV	CoV	NNP
cord-260577-t4w4pw12	125	31	-	-	HYPH
cord-260577-t4w4pw12	125	32	mediated	mediate	VBN
cord-260577-t4w4pw12	125	33	lung	lung	NN
cord-260577-t4w4pw12	125	34	injury	injury	NN
cord-260577-t4w4pw12	125	35	[	[	-LRB-
cord-260577-t4w4pw12	125	36	8	8	CD
cord-260577-t4w4pw12	125	37	]	]	-RRB-
cord-260577-t4w4pw12	125	38	.	.	.
cord-260577-t4w4pw12	126	1	Therefore	therefore	RB
cord-260577-t4w4pw12	126	2	,	,	,
cord-260577-t4w4pw12	126	3	in	in	IN
cord-260577-t4w4pw12	126	4	acute	acute	JJ
cord-260577-t4w4pw12	126	5	lung	lung	NN
cord-260577-t4w4pw12	126	6	injury	injury	NN
cord-260577-t4w4pw12	126	7	,	,	,
cord-260577-t4w4pw12	126	8	ACE	ACE	NNP
cord-260577-t4w4pw12	126	9	,	,	,
cord-260577-t4w4pw12	126	10	Ang	Ang	NNP
cord-260577-t4w4pw12	126	11	II	II	NNP
cord-260577-t4w4pw12	126	12	and	and	CC
cord-260577-t4w4pw12	126	13	AT	at	IN
cord-260577-t4w4pw12	126	14	1	1	CD
cord-260577-t4w4pw12	126	15	R	r	NN
cord-260577-t4w4pw12	126	16	promote	promote	VBP
cord-260577-t4w4pw12	126	17	acute	acute	JJ
cord-260577-t4w4pw12	126	18	lung	lung	NN
cord-260577-t4w4pw12	126	19	injury	injury	NN
cord-260577-t4w4pw12	126	20	,	,	,
cord-260577-t4w4pw12	126	21	whereas	whereas	IN
cord-260577-t4w4pw12	126	22	ACE2	ACE2	NNP
cord-260577-t4w4pw12	126	23	and	and	CC
cord-260577-t4w4pw12	126	24	the	the	DT
cord-260577-t4w4pw12	126	25	AT	AT	NNP
cord-260577-t4w4pw12	126	26	2	2	CD
cord-260577-t4w4pw12	126	27	R	r	NN
cord-260577-t4w4pw12	126	28	protect	protect	NN
cord-260577-t4w4pw12	126	29	from	from	IN
cord-260577-t4w4pw12	126	30	lung	lung	NN
cord-260577-t4w4pw12	126	31	injury	injury	NN
cord-260577-t4w4pw12	126	32	.	.	.
cord-260577-t4w4pw12	127	1	These	these	DT
cord-260577-t4w4pw12	127	2	findings	finding	NNS
cord-260577-t4w4pw12	127	3	might	may	MD
cord-260577-t4w4pw12	127	4	provide	provide	VB
cord-260577-t4w4pw12	127	5	the	the	DT
cord-260577-t4w4pw12	127	6	opportunity	opportunity	NN
cord-260577-t4w4pw12	127	7	to	to	TO
cord-260577-t4w4pw12	127	8	develop	develop	VB
cord-260577-t4w4pw12	127	9	recombinant	recombinant	JJ
cord-260577-t4w4pw12	127	10	ACE2	ACE2	NNP
cord-260577-t4w4pw12	127	11	as	as	IN
cord-260577-t4w4pw12	127	12	a	a	DT
cord-260577-t4w4pw12	127	13	novel	novel	JJ
cord-260577-t4w4pw12	127	14	drug	drug	NN
cord-260577-t4w4pw12	127	15	in	in	IN
cord-260577-t4w4pw12	127	16	ARDS	ARDS	NNP
cord-260577-t4w4pw12	127	17	along	along	IN
cord-260577-t4w4pw12	127	18	with	with	IN
cord-260577-t4w4pw12	127	19	AT	AT	NNP
cord-260577-t4w4pw12	127	20	1	1	CD
cord-260577-t4w4pw12	127	21	R	r	NN
cord-260577-t4w4pw12	127	22	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	127	23	or	or	CC
cord-260577-t4w4pw12	127	24	ACE	ACE	NNP
cord-260577-t4w4pw12	127	25	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	127	26	to	to	TO
cord-260577-t4w4pw12	127	27	possibly	possibly	RB
cord-260577-t4w4pw12	127	28	treat	treat	VB
cord-260577-t4w4pw12	127	29	emerging	emerge	VBG
cord-260577-t4w4pw12	127	30	infectious	infectious	JJ
cord-260577-t4w4pw12	127	31	lung	lung	NN
cord-260577-t4w4pw12	127	32	diseases	disease	NNS
cord-260577-t4w4pw12	127	33	such	such	JJ
cord-260577-t4w4pw12	127	34	as	as	IN
cord-260577-t4w4pw12	127	35	avian	avian	JJ
cord-260577-t4w4pw12	127	36	influenza	influenza	NN
cord-260577-t4w4pw12	127	37	A	a	NN
cord-260577-t4w4pw12	127	38	(	(	-LRB-
cord-260577-t4w4pw12	127	39	H5N1	H5N1	NNP
cord-260577-t4w4pw12	127	40	)	)	-RRB-
cord-260577-t4w4pw12	127	41	and	and	CC
cord-260577-t4w4pw12	127	42	other	other	JJ
cord-260577-t4w4pw12	127	43	diseases	disease	NNS
cord-260577-t4w4pw12	127	44	that	that	WDT
cord-260577-t4w4pw12	127	45	affect	affect	VBP
cord-260577-t4w4pw12	127	46	lung	lung	NN
cord-260577-t4w4pw12	127	47	function	function	NN
cord-260577-t4w4pw12	127	48	(	(	-LRB-
cord-260577-t4w4pw12	127	49	Table	table	NN
cord-260577-t4w4pw12	127	50	1	1	CD
cord-260577-t4w4pw12	127	51	)	)	-RRB-
cord-260577-t4w4pw12	127	52	.	.	.
cord-260577-t4w4pw12	128	1	In	in	IN
cord-260577-t4w4pw12	128	2	addition	addition	NN
cord-260577-t4w4pw12	128	3	,	,	,
cord-260577-t4w4pw12	128	4	as	as	IN
cord-260577-t4w4pw12	128	5	ACE2	ACE2	NNP
cord-260577-t4w4pw12	128	6	is	be	VBZ
cord-260577-t4w4pw12	128	7	an	an	DT
cord-260577-t4w4pw12	128	8	unspecific	unspecific	JJ
cord-260577-t4w4pw12	128	9	protease	protease	NN
cord-260577-t4w4pw12	128	10	,	,	,
cord-260577-t4w4pw12	128	11	it	-PRON-	PRP
cord-260577-t4w4pw12	128	12	would	would	MD
cord-260577-t4w4pw12	128	13	be	be	VB
cord-260577-t4w4pw12	128	14	also	also	RB
cord-260577-t4w4pw12	128	15	interesting	interesting	JJ
cord-260577-t4w4pw12	128	16	to	to	TO
cord-260577-t4w4pw12	128	17	investigate	investigate	VB
cord-260577-t4w4pw12	128	18	the	the	DT
cord-260577-t4w4pw12	128	19	role	role	NN
cord-260577-t4w4pw12	128	20	of	of	IN
cord-260577-t4w4pw12	128	21	ACE2	ACE2	NNP
cord-260577-t4w4pw12	128	22	and	and	CC
cord-260577-t4w4pw12	128	23	its	-PRON-	PRP$
cord-260577-t4w4pw12	128	24	metabolites	metabolite	NNS
cord-260577-t4w4pw12	128	25	including	include	VBG
cord-260577-t4w4pw12	128	26	angiotensin-(1	angiotensin-(1	NN
cord-260577-t4w4pw12	128	27	-	-	SYM
cord-260577-t4w4pw12	128	28	7	7	CD
cord-260577-t4w4pw12	128	29	)	)	-RRB-
cord-260577-t4w4pw12	128	30	,	,	,
cord-260577-t4w4pw12	128	31	des	des	NNP
cord-260577-t4w4pw12	128	32	-	-	HYPH
cord-260577-t4w4pw12	128	33	Arg(9)-bradykinin	Arg(9)-bradykinin	NNP
cord-260577-t4w4pw12	128	34	,	,	,
cord-260577-t4w4pw12	128	35	apelin	apelin	NNP
cord-260577-t4w4pw12	128	36	or	or	CC
cord-260577-t4w4pw12	128	37	dynorphin	dynorphin	NNP
cord-260577-t4w4pw12	128	38	in	in	IN
cord-260577-t4w4pw12	128	39	ARDS	ARDS	NNP
cord-260577-t4w4pw12	128	40	.	.	.
cord-260577-t4w4pw12	129	1	We	-PRON-	PRP
cord-260577-t4w4pw12	129	2	look	look	VBP
cord-260577-t4w4pw12	129	3	forward	forward	RB
cord-260577-t4w4pw12	129	4	to	to	IN
cord-260577-t4w4pw12	129	5	the	the	DT
cord-260577-t4w4pw12	129	6	use	use	NN
cord-260577-t4w4pw12	129	7	of	of	IN
cord-260577-t4w4pw12	129	8	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	129	9	system	system	NN
cord-260577-t4w4pw12	129	10	-	-	HYPH
cord-260577-t4w4pw12	129	11	modulating	modulate	VBG
cord-260577-t4w4pw12	129	12	agents	agent	NNS
cord-260577-t4w4pw12	129	13	/	/	SYM
cord-260577-t4w4pw12	129	14	molecules	molecule	NNS
cord-260577-t4w4pw12	129	15	,	,	,
cord-260577-t4w4pw12	129	16	in	in	IN
cord-260577-t4w4pw12	129	17	particular	particular	JJ
cord-260577-t4w4pw12	129	18	ACE2	ACE2	NNP
cord-260577-t4w4pw12	129	19	,	,	,
cord-260577-t4w4pw12	129	20	as	as	IN
cord-260577-t4w4pw12	129	21	novel	novel	JJ
cord-260577-t4w4pw12	129	22	therapeutic	therapeutic	JJ
cord-260577-t4w4pw12	129	23	agents	agent	NNS
cord-260577-t4w4pw12	129	24	to	to	TO
cord-260577-t4w4pw12	129	25	treat	treat	VB
cord-260577-t4w4pw12	129	26	severe	severe	JJ
cord-260577-t4w4pw12	129	27	acute	acute	JJ
cord-260577-t4w4pw12	129	28	lung	lung	NN
cord-260577-t4w4pw12	129	29	failure	failure	NN
cord-260577-t4w4pw12	129	30	,	,	,
cord-260577-t4w4pw12	129	31	a	a	DT
cord-260577-t4w4pw12	129	32	syndrome	syndrome	NN
cord-260577-t4w4pw12	129	33	that	that	WDT
cord-260577-t4w4pw12	129	34	affects	affect	VBZ
cord-260577-t4w4pw12	129	35	millions	million	NNS
cord-260577-t4w4pw12	129	36	of	of	IN
cord-260577-t4w4pw12	129	37	people	people	NNS
cord-260577-t4w4pw12	129	38	without	without	IN
cord-260577-t4w4pw12	129	39	any	any	DT
cord-260577-t4w4pw12	129	40	yet	yet	RB
cord-260577-t4w4pw12	129	41	effective	effective	JJ
cord-260577-t4w4pw12	129	42	drug	drug	NN
cord-260577-t4w4pw12	129	43	treatments	treatment	NNS
cord-260577-t4w4pw12	129	44	.	.	.
cord-260577-t4w4pw12	130	1	Reported	report	VBN
cord-260577-t4w4pw12	130	2	studies	study	NNS
cord-260577-t4w4pw12	130	3	and	and	CC
cord-260577-t4w4pw12	130	4	references	reference	NNS
cord-260577-t4w4pw12	130	5	In	in	IN
cord-260577-t4w4pw12	130	6	vivo	vivo	NN
cord-260577-t4w4pw12	130	7	mouse	mouse	NN
cord-260577-t4w4pw12	130	8	[	[	-LRB-
cord-260577-t4w4pw12	130	9	7	7	CD
cord-260577-t4w4pw12	130	10	,	,	,
cord-260577-t4w4pw12	130	11	8	8	CD
cord-260577-t4w4pw12	130	12	]	]	-RRB-
cord-260577-t4w4pw12	131	1	Angiotensin	angiotensin	NN
cord-260577-t4w4pw12	131	2	II	II	NNP
cord-260577-t4w4pw12	131	3	receptor	receptor	NN
cord-260577-t4w4pw12	131	4	type	type	NN
cord-260577-t4w4pw12	131	5	1	1	CD
cord-260577-t4w4pw12	131	6	(	(	-LRB-
cord-260577-t4w4pw12	131	7	AT	at	IN
cord-260577-t4w4pw12	131	8	1	1	CD
cord-260577-t4w4pw12	131	9	R	r	NN
cord-260577-t4w4pw12	131	10	)	)	-RRB-
cord-260577-t4w4pw12	131	11	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	131	12	Human	Human	NNP
cord-260577-t4w4pw12	131	13	[	[	-LRB-
cord-260577-t4w4pw12	131	14	28	28	CD
cord-260577-t4w4pw12	131	15	]	]	-RRB-
cord-260577-t4w4pw12	132	1	In	in	IN
cord-260577-t4w4pw12	132	2	vivo	vivo	NN
cord-260577-t4w4pw12	132	3	mouse	mouse	NN
cord-260577-t4w4pw12	132	4	[	[	-LRB-
cord-260577-t4w4pw12	132	5	7	7	CD
cord-260577-t4w4pw12	132	6	,	,	,
cord-260577-t4w4pw12	132	7	8	8	CD
cord-260577-t4w4pw12	132	8	]	]	-RRB-
cord-260577-t4w4pw12	133	1	In	in	IN
cord-260577-t4w4pw12	133	2	vivo	vivo	FW
cord-260577-t4w4pw12	133	3	rat	rat	NN
cord-260577-t4w4pw12	133	4	[	[	-LRB-
cord-260577-t4w4pw12	133	5	27	27	CD
cord-260577-t4w4pw12	133	6	]	]	-RRB-
cord-260577-t4w4pw12	134	1	Angiotensin	angiotensin	NN
cord-260577-t4w4pw12	134	2	converting	convert	VBG
cord-260577-t4w4pw12	134	3	enzyme	enzyme	NN
cord-260577-t4w4pw12	134	4	(	(	-LRB-
cord-260577-t4w4pw12	134	5	ACE	ace	NN
cord-260577-t4w4pw12	134	6	)	)	-RRB-
cord-260577-t4w4pw12	134	7	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	135	1	In	in	IN
cord-260577-t4w4pw12	135	2	vivo	vivo	NN
cord-260577-t4w4pw12	135	3	mouse	mouse	NN
cord-260577-t4w4pw12	135	4	[	[	-LRB-
cord-260577-t4w4pw12	135	5	7	7	CD
cord-260577-t4w4pw12	135	6	]	]	-RRB-
cord-260577-t4w4pw12	136	1	In	in	IN
cord-260577-t4w4pw12	136	2	vivo	vivo	FW
cord-260577-t4w4pw12	136	3	rat	rat	NN
cord-260577-t4w4pw12	136	4	[	[	-LRB-
cord-260577-t4w4pw12	136	5	28	28	CD
cord-260577-t4w4pw12	136	6	]	]	-RRB-
cord-260577-t4w4pw12	136	7	 	 	_SP
cord-260577-t4w4pw12	136	8	The	the	DT
cord-260577-t4w4pw12	136	9	biochemistry	biochemistry	NN
cord-260577-t4w4pw12	136	10	of	of	IN
cord-260577-t4w4pw12	136	11	the	the	DT
cord-260577-t4w4pw12	136	12	renin	renin	NN
cord-260577-t4w4pw12	136	13	-	-	HYPH
cord-260577-t4w4pw12	136	14	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	136	15	system	system	NN
cord-260577-t4w4pw12	137	1	Peptidyl	Peptidyl	NNP
cord-260577-t4w4pw12	137	2	dipeptidase	dipeptidase	NN
cord-260577-t4w4pw12	138	1	A	a	DT
cord-260577-t4w4pw12	139	1	:	:	:
cord-260577-t4w4pw12	139	2	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	139	3	I	I	NNP
cord-260577-t4w4pw12	139	4	-	-	HYPH
cord-260577-t4w4pw12	139	5	converting	convert	VBG
cord-260577-t4w4pw12	139	6	enzyme	enzyme	NN
cord-260577-t4w4pw12	139	7	A	a	DT
cord-260577-t4w4pw12	139	8	novel	novel	JJ
cord-260577-t4w4pw12	139	9	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	139	10	-	-	HYPH
cord-260577-t4w4pw12	139	11	converting	convert	VBG
cord-260577-t4w4pw12	139	12	enzymerelated	enzymerelated	JJ
cord-260577-t4w4pw12	139	13	carboxypeptidase	carboxypeptidase	NN
cord-260577-t4w4pw12	139	14	(	(	-LRB-
cord-260577-t4w4pw12	139	15	ACE2	ACE2	NNP
cord-260577-t4w4pw12	139	16	)	)	-RRB-
cord-260577-t4w4pw12	139	17	converts	convert	VBZ
cord-260577-t4w4pw12	139	18	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	139	19	I	-PRON-	PRP
cord-260577-t4w4pw12	139	20	to	to	IN
cord-260577-t4w4pw12	139	21	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	139	22	1	1	CD
cord-260577-t4w4pw12	140	1	-9	-9	NNP
cord-260577-t4w4pw12	140	2	A	a	DT
cord-260577-t4w4pw12	140	3	human	human	JJ
cord-260577-t4w4pw12	140	4	homolog	homolog	NN
cord-260577-t4w4pw12	140	5	of	of	IN
cord-260577-t4w4pw12	140	6	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	140	7	-	-	HYPH
cord-260577-t4w4pw12	140	8	converting	convert	VBG
cord-260577-t4w4pw12	140	9	enzyme	enzyme	NN
cord-260577-t4w4pw12	140	10	.	.	.
cord-260577-t4w4pw12	141	1	Cloning	clone	VBG
cord-260577-t4w4pw12	141	2	and	and	CC
cord-260577-t4w4pw12	141	3	functional	functional	JJ
cord-260577-t4w4pw12	141	4	expression	expression	NN
cord-260577-t4w4pw12	141	5	as	as	IN
cord-260577-t4w4pw12	141	6	a	a	DT
cord-260577-t4w4pw12	141	7	captopril	captopril	NN
cord-260577-t4w4pw12	141	8	-	-	HYPH
cord-260577-t4w4pw12	141	9	insensitive	insensitive	JJ
cord-260577-t4w4pw12	141	10	carboxypeptidase	carboxypeptidase	NN
cord-260577-t4w4pw12	141	11	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	141	12	-	-	HYPH
cord-260577-t4w4pw12	141	13	converting	convert	VBG
cord-260577-t4w4pw12	141	14	enzyme	enzyme	NN
cord-260577-t4w4pw12	141	15	2	2	CD
cord-260577-t4w4pw12	141	16	is	be	VBZ
cord-260577-t4w4pw12	141	17	a	a	DT
cord-260577-t4w4pw12	141	18	functional	functional	JJ
cord-260577-t4w4pw12	141	19	receptor	receptor	NN
cord-260577-t4w4pw12	141	20	for	for	IN
cord-260577-t4w4pw12	141	21	the	the	DT
cord-260577-t4w4pw12	141	22	SARS	SARS	NNP
cord-260577-t4w4pw12	141	23	coronavirus	coronavirus	NN
cord-260577-t4w4pw12	141	24	Severe	severe	JJ
cord-260577-t4w4pw12	141	25	acute	acute	JJ
cord-260577-t4w4pw12	141	26	respiratory	respiratory	JJ
cord-260577-t4w4pw12	141	27	syndrome	syndrome	NN
cord-260577-t4w4pw12	141	28	Angiotensin	angiotensin	NN
cord-260577-t4w4pw12	141	29	-	-	HYPH
cord-260577-t4w4pw12	141	30	converting	convert	VBG
cord-260577-t4w4pw12	141	31	enzyme	enzyme	NN
cord-260577-t4w4pw12	141	32	2	2	CD
cord-260577-t4w4pw12	141	33	protects	protect	VBZ
cord-260577-t4w4pw12	141	34	from	from	IN
cord-260577-t4w4pw12	141	35	severe	severe	JJ
cord-260577-t4w4pw12	141	36	acute	acute	JJ
cord-260577-t4w4pw12	141	37	lung	lung	NN
cord-260577-t4w4pw12	141	38	failure	failure	NN
cord-260577-t4w4pw12	142	1	A	a	DT
cord-260577-t4w4pw12	142	2	crucial	crucial	JJ
cord-260577-t4w4pw12	142	3	role	role	NN
cord-260577-t4w4pw12	142	4	of	of	IN
cord-260577-t4w4pw12	142	5	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	142	6	converting	convert	VBG
cord-260577-t4w4pw12	142	7	enzyme	enzyme	NN
cord-260577-t4w4pw12	142	8	2	2	CD
cord-260577-t4w4pw12	142	9	(	(	-LRB-
cord-260577-t4w4pw12	142	10	ACE2	ACE2	NNP
cord-260577-t4w4pw12	142	11	)	)	-RRB-
cord-260577-t4w4pw12	142	12	in	in	IN
cord-260577-t4w4pw12	142	13	SARS	SARS	NNP
cord-260577-t4w4pw12	142	14	coronavirus	coronavirus	NN
cord-260577-t4w4pw12	142	15	-	-	HYPH
cord-260577-t4w4pw12	142	16	induced	induce	VBN
cord-260577-t4w4pw12	142	17	lung	lung	NN
cord-260577-t4w4pw12	142	18	injury	injury	NN
cord-260577-t4w4pw12	142	19	Avian	avian	JJ
cord-260577-t4w4pw12	142	20	influenza	influenza	NN
cord-260577-t4w4pw12	142	21	virus	virus	NN
cord-260577-t4w4pw12	142	22	infection	infection	NN
cord-260577-t4w4pw12	142	23	of	of	IN
cord-260577-t4w4pw12	142	24	children	child	NNS
cord-260577-t4w4pw12	142	25	in	in	IN
cord-260577-t4w4pw12	142	26	Vietnam	Vietnam	NNP
cord-260577-t4w4pw12	142	27	and	and	CC
cord-260577-t4w4pw12	142	28	Thailand	Thailand	NNP
cord-260577-t4w4pw12	143	1	The	the	DT
cord-260577-t4w4pw12	143	2	acute	acute	JJ
cord-260577-t4w4pw12	143	3	respiratory	respiratory	JJ
cord-260577-t4w4pw12	143	4	distress	distress	NN
cord-260577-t4w4pw12	143	5	syndrome	syndrome	NN
cord-260577-t4w4pw12	143	6	Familial	familial	JJ
cord-260577-t4w4pw12	143	7	resemblance	resemblance	NN
cord-260577-t4w4pw12	143	8	of	of	IN
cord-260577-t4w4pw12	143	9	plasma	plasma	NN
cord-260577-t4w4pw12	143	10	angiotensinconverting	angiotensinconverting	NN
cord-260577-t4w4pw12	143	11	enzyme	enzyme	NN
cord-260577-t4w4pw12	143	12	level	level	NN
cord-260577-t4w4pw12	143	13	:	:	:
cord-260577-t4w4pw12	143	14	the	the	DT
cord-260577-t4w4pw12	143	15	Nancy	Nancy	NNP
cord-260577-t4w4pw12	143	16	Study	Study	NNP
cord-260577-t4w4pw12	143	17	An	an	DT
cord-260577-t4w4pw12	143	18	insertion	insertion	NN
cord-260577-t4w4pw12	143	19	/	/	SYM
cord-260577-t4w4pw12	143	20	deletion	deletion	NN
cord-260577-t4w4pw12	143	21	polymorphism	polymorphism	NN
cord-260577-t4w4pw12	143	22	in	in	IN
cord-260577-t4w4pw12	143	23	the	the	DT
cord-260577-t4w4pw12	143	24	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	143	25	I	I	NNP
cord-260577-t4w4pw12	143	26	-	-	HYPH
cord-260577-t4w4pw12	143	27	converting	convert	VBG
cord-260577-t4w4pw12	143	28	enzyme	enzyme	NN
cord-260577-t4w4pw12	143	29	gene	gene	NN
cord-260577-t4w4pw12	143	30	accounting	account	VBG
cord-260577-t4w4pw12	143	31	for	for	IN
cord-260577-t4w4pw12	143	32	half	half	PDT
cord-260577-t4w4pw12	143	33	the	the	DT
cord-260577-t4w4pw12	143	34	variance	variance	NN
cord-260577-t4w4pw12	143	35	of	of	IN
cord-260577-t4w4pw12	143	36	serum	serum	NN
cord-260577-t4w4pw12	143	37	enzyme	enzyme	NN
cord-260577-t4w4pw12	143	38	levels	level	NNS
cord-260577-t4w4pw12	143	39	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	143	40	converting	convert	VBG
cord-260577-t4w4pw12	143	41	enzyme	enzyme	NN
cord-260577-t4w4pw12	143	42	insertion/	insertion/	ADD
cord-260577-t4w4pw12	144	1	deletion	deletion	NN
cord-260577-t4w4pw12	144	2	polymorphism	polymorphism	NN
cord-260577-t4w4pw12	144	3	is	be	VBZ
cord-260577-t4w4pw12	144	4	associated	associate	VBN
cord-260577-t4w4pw12	144	5	with	with	IN
cord-260577-t4w4pw12	144	6	susceptibility	susceptibility	NN
cord-260577-t4w4pw12	144	7	and	and	CC
cord-260577-t4w4pw12	144	8	outcome	outcome	NN
cord-260577-t4w4pw12	144	9	in	in	IN
cord-260577-t4w4pw12	144	10	acute	acute	JJ
cord-260577-t4w4pw12	144	11	respiratory	respiratory	JJ
cord-260577-t4w4pw12	144	12	distress	distress	NN
cord-260577-t4w4pw12	144	13	syndrome	syndrome	NN
cord-260577-t4w4pw12	144	14	Polymorphism	polymorphism	NN
cord-260577-t4w4pw12	144	15	of	of	IN
cord-260577-t4w4pw12	144	16	the	the	DT
cord-260577-t4w4pw12	144	17	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	144	18	-	-	HYPH
cord-260577-t4w4pw12	144	19	converting	convert	VBG
cord-260577-t4w4pw12	144	20	enzyme	enzyme	NN
cord-260577-t4w4pw12	144	21	gene	gene	NN
cord-260577-t4w4pw12	144	22	affects	affect	VBZ
cord-260577-t4w4pw12	144	23	the	the	DT
cord-260577-t4w4pw12	144	24	outcome	outcome	NN
cord-260577-t4w4pw12	144	25	of	of	IN
cord-260577-t4w4pw12	144	26	acute	acute	JJ
cord-260577-t4w4pw12	144	27	respiratory	respiratory	JJ
cord-260577-t4w4pw12	144	28	distress	distress	NN
cord-260577-t4w4pw12	144	29	syndrome	syndrome	NN
cord-260577-t4w4pw12	144	30	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	144	31	converting	convert	VBG
cord-260577-t4w4pw12	144	32	enzyme	enzyme	NN
cord-260577-t4w4pw12	144	33	in	in	IN
cord-260577-t4w4pw12	144	34	bronchoalveolar	bronchoalveolar	NNP
cord-260577-t4w4pw12	144	35	lavage	lavage	NN
cord-260577-t4w4pw12	144	36	in	in	IN
cord-260577-t4w4pw12	144	37	ARDS	ARDS	NNP
cord-260577-t4w4pw12	144	38	Pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	144	39	capillary	capillary	JJ
cord-260577-t4w4pw12	144	40	endothelium	endothelium	NN
cord-260577-t4w4pw12	144	41	-	-	HYPH
cord-260577-t4w4pw12	144	42	bound	bind	VBN
cord-260577-t4w4pw12	144	43	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	144	44	-	-	HYPH
cord-260577-t4w4pw12	144	45	converting	convert	VBG
cord-260577-t4w4pw12	144	46	enzyme	enzyme	NN
cord-260577-t4w4pw12	144	47	activity	activity	NN
cord-260577-t4w4pw12	144	48	in	in	IN
cord-260577-t4w4pw12	144	49	acute	acute	JJ
cord-260577-t4w4pw12	144	50	lung	lung	NN
cord-260577-t4w4pw12	144	51	injury	injury	NN
cord-260577-t4w4pw12	145	1	The	the	DT
cord-260577-t4w4pw12	145	2	impact	impact	NN
cord-260577-t4w4pw12	145	3	of	of	IN
cord-260577-t4w4pw12	145	4	prior	prior	JJ
cord-260577-t4w4pw12	145	5	outpatient	outpatient	NN
cord-260577-t4w4pw12	145	6	ACE	ace	NN
cord-260577-t4w4pw12	145	7	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	145	8	use	use	NN
cord-260577-t4w4pw12	145	9	on	on	IN
cord-260577-t4w4pw12	145	10	30-day	30-day	CD
cord-260577-t4w4pw12	145	11	mortality	mortality	NN
cord-260577-t4w4pw12	145	12	for	for	IN
cord-260577-t4w4pw12	145	13	patients	patient	NNS
cord-260577-t4w4pw12	145	14	hospitalized	hospitalize	VBN
cord-260577-t4w4pw12	145	15	with	with	IN
cord-260577-t4w4pw12	145	16	communityacquired	communityacquired	JJ
cord-260577-t4w4pw12	145	17	pneumonia	pneumonia	NN
cord-260577-t4w4pw12	145	18	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	145	19	-	-	HYPH
cord-260577-t4w4pw12	145	20	converting	convert	VBG
cord-260577-t4w4pw12	145	21	enzyme	enzyme	NN
cord-260577-t4w4pw12	145	22	2	2	CD
cord-260577-t4w4pw12	145	23	is	be	VBZ
cord-260577-t4w4pw12	145	24	an	an	DT
cord-260577-t4w4pw12	145	25	essential	essential	JJ
cord-260577-t4w4pw12	145	26	regulator	regulator	NN
cord-260577-t4w4pw12	145	27	of	of	IN
cord-260577-t4w4pw12	145	28	heart	heart	NN
cord-260577-t4w4pw12	145	29	function	function	NN
cord-260577-t4w4pw12	146	1	Deletion	deletion	NN
cord-260577-t4w4pw12	146	2	of	of	IN
cord-260577-t4w4pw12	146	3	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	146	4	-	-	HYPH
cord-260577-t4w4pw12	146	5	converting	convert	VBG
cord-260577-t4w4pw12	146	6	enzyme	enzyme	NN
cord-260577-t4w4pw12	146	7	2	2	CD
cord-260577-t4w4pw12	146	8	accelerates	accelerate	VBZ
cord-260577-t4w4pw12	146	9	pressure	pressure	NN
cord-260577-t4w4pw12	146	10	overload	overload	NN
cord-260577-t4w4pw12	146	11	-	-	HYPH
cord-260577-t4w4pw12	146	12	induced	induce	VBN
cord-260577-t4w4pw12	146	13	cardiac	cardiac	JJ
cord-260577-t4w4pw12	146	14	dysfunction	dysfunction	NN
cord-260577-t4w4pw12	146	15	by	by	IN
cord-260577-t4w4pw12	146	16	increasing	increase	VBG
cord-260577-t4w4pw12	146	17	local	local	JJ
cord-260577-t4w4pw12	146	18	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	146	19	II	II	NNP
cord-260577-t4w4pw12	146	20	Haemodynamic	Haemodynamic	NNP
cord-260577-t4w4pw12	146	21	and	and	CC
cord-260577-t4w4pw12	146	22	endocrine	endocrine	JJ
cord-260577-t4w4pw12	146	23	effects	effect	NNS
cord-260577-t4w4pw12	146	24	of	of	IN
cord-260577-t4w4pw12	146	25	type	type	NN
cord-260577-t4w4pw12	146	26	1	1	CD
cord-260577-t4w4pw12	146	27	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	146	28	II	ii	CD
cord-260577-t4w4pw12	146	29	receptor	receptor	NN
cord-260577-t4w4pw12	146	30	blockade	blockade	NN
cord-260577-t4w4pw12	146	31	in	in	IN
cord-260577-t4w4pw12	146	32	patients	patient	NNS
cord-260577-t4w4pw12	146	33	with	with	IN
cord-260577-t4w4pw12	146	34	hypoxaemic	hypoxaemic	NNP
cord-260577-t4w4pw12	146	35	cor	cor	NNP
cord-260577-t4w4pw12	146	36	pulmonale	pulmonale	NNP
cord-260577-t4w4pw12	146	37	Pulmonary	Pulmonary	NNP
cord-260577-t4w4pw12	146	38	edema	edema	NN
cord-260577-t4w4pw12	146	39	induced	induce	VBN
cord-260577-t4w4pw12	146	40	by	by	IN
cord-260577-t4w4pw12	146	41	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	146	42	I	-PRON-	PRP
cord-260577-t4w4pw12	146	43	in	in	IN
cord-260577-t4w4pw12	146	44	rats	rat	NNS
cord-260577-t4w4pw12	147	1	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	147	2	II	II	NNP
cord-260577-t4w4pw12	147	3	-	-	HYPH
cord-260577-t4w4pw12	147	4	induced	induce	VBN
cord-260577-t4w4pw12	147	5	pulmonary	pulmonary	JJ
cord-260577-t4w4pw12	147	6	edema	edema	NN
cord-260577-t4w4pw12	147	7	in	in	IN
cord-260577-t4w4pw12	147	8	a	a	DT
cord-260577-t4w4pw12	147	9	rabbit	rabbit	NN
cord-260577-t4w4pw12	147	10	model	model	NN
cord-260577-t4w4pw12	147	11	Effect	effect	NN
cord-260577-t4w4pw12	147	12	of	of	IN
cord-260577-t4w4pw12	147	13	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	147	14	II	II	NNP
cord-260577-t4w4pw12	147	15	on	on	IN
cord-260577-t4w4pw12	147	16	microvascular	microvascular	JJ
cord-260577-t4w4pw12	147	17	permeability	permeability	NN
cord-260577-t4w4pw12	148	1	Bradykinin	bradykinin	NN
cord-260577-t4w4pw12	148	2	receptor	receptor	NN
cord-260577-t4w4pw12	148	3	ligands	ligand	NNS
cord-260577-t4w4pw12	148	4	:	:	:
cord-260577-t4w4pw12	148	5	therapeutic	therapeutic	JJ
cord-260577-t4w4pw12	148	6	perspectives	perspective	NNS
cord-260577-t4w4pw12	149	1	Bradykinin	Bradykinin	NNP
cord-260577-t4w4pw12	149	2	B(1	B(1	NNP
cord-260577-t4w4pw12	149	3	)	)	-RRB-
cord-260577-t4w4pw12	150	1	receptor	receptor	NN
cord-260577-t4w4pw12	150	2	-	-	HYPH
cord-260577-t4w4pw12	150	3	mediated	mediate	VBN
cord-260577-t4w4pw12	150	4	changes	change	NNS
cord-260577-t4w4pw12	150	5	in	in	IN
cord-260577-t4w4pw12	150	6	renal	renal	JJ
cord-260577-t4w4pw12	150	7	hemodynamics	hemodynamic	NNS
cord-260577-t4w4pw12	150	8	during	during	IN
cord-260577-t4w4pw12	150	9	endotoxin	endotoxin	NN
cord-260577-t4w4pw12	150	10	-	-	HYPH
cord-260577-t4w4pw12	150	11	induced	induce	VBN
cord-260577-t4w4pw12	150	12	inflammation	inflammation	NN
cord-260577-t4w4pw12	150	13	Hydrolysis	hydrolysis	NN
cord-260577-t4w4pw12	150	14	of	of	IN
cord-260577-t4w4pw12	150	15	biological	biological	JJ
cord-260577-t4w4pw12	150	16	peptides	peptide	NNS
cord-260577-t4w4pw12	150	17	by	by	IN
cord-260577-t4w4pw12	150	18	human	human	JJ
cord-260577-t4w4pw12	150	19	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	150	20	-	-	HYPH
cord-260577-t4w4pw12	150	21	converting	convert	VBG
cord-260577-t4w4pw12	150	22	enzyme	enzyme	NN
cord-260577-t4w4pw12	150	23	-	-	HYPH
cord-260577-t4w4pw12	150	24	related	relate	VBN
cord-260577-t4w4pw12	150	25	carboxypeptidase	carboxypeptidase	NN
cord-260577-t4w4pw12	150	26	Losartan	Losartan	NNP
cord-260577-t4w4pw12	150	27	,	,	,
cord-260577-t4w4pw12	150	28	a	a	DT
cord-260577-t4w4pw12	150	29	selective	selective	JJ
cord-260577-t4w4pw12	150	30	inhibitor	inhibitor	NN
cord-260577-t4w4pw12	150	31	of	of	IN
cord-260577-t4w4pw12	150	32	subtype	subtype	NN
cord-260577-t4w4pw12	150	33	AT1	at1	NN
cord-260577-t4w4pw12	150	34	receptors	receptor	NNS
cord-260577-t4w4pw12	150	35	for	for	IN
cord-260577-t4w4pw12	150	36	angiotensin	angiotensin	NN
cord-260577-t4w4pw12	150	37	II	II	NNP
cord-260577-t4w4pw12	150	38	,	,	,
cord-260577-t4w4pw12	150	39	inhibits	inhibit	VBZ
cord-260577-t4w4pw12	150	40	neutrophil	neutrophil	NN
cord-260577-t4w4pw12	150	41	recruitment	recruitment	NN
cord-260577-t4w4pw12	150	42	in	in	IN
cord-260577-t4w4pw12	150	43	the	the	DT
cord-260577-t4w4pw12	150	44	lung	lung	NN
cord-260577-t4w4pw12	150	45	triggered	trigger	VBN
cord-260577-t4w4pw12	150	46	by	by	IN
cord-260577-t4w4pw12	150	47	fMLP	fMLP	NNP
cord-260577-t4w4pw12	150	48	Angiotensin	Angiotensin	NNP
cord-260577-t4w4pw12	150	49	II	II	NNP
cord-260577-t4w4pw12	150	50	receptor	receptor	NN
cord-260577-t4w4pw12	150	51	blockade	blockade	NN
cord-260577-t4w4pw12	150	52	inhibits	inhibit	VBZ
cord-260577-t4w4pw12	150	53	pneumocyte	pneumocyte	NNP
cord-260577-t4w4pw12	150	54	apoptosis	apoptosis	NN
cord-260577-t4w4pw12	150	55	in	in	IN
cord-260577-t4w4pw12	150	56	experimental	experimental	JJ
cord-260577-t4w4pw12	150	57	meconium	meconium	NN
cord-260577-t4w4pw12	150	58	aspiration	aspiration	NN
cord-260577-t4w4pw12	151	1	We	-PRON-	PRP
cord-260577-t4w4pw12	151	2	thank	thank	VBP
cord-260577-t4w4pw12	151	3	Chengyu	Chengyu	NNP
cord-260577-t4w4pw12	151	4	Jiang	Jiang	NNP
cord-260577-t4w4pw12	151	5	,	,	,
cord-260577-t4w4pw12	151	6	Shuan	Shuan	NNP
cord-260577-t4w4pw12	151	7	Rao	Rao	NNP
cord-260577-t4w4pw12	151	8	and	and	CC
cord-260577-t4w4pw12	151	9	many	many	JJ
cord-260577-t4w4pw12	151	10	others	other	NNS
cord-260577-t4w4pw12	151	11	for	for	IN
cord-260577-t4w4pw12	151	12	their	-PRON-	PRP$
cord-260577-t4w4pw12	151	13	contributions	contribution	NNS
cord-260577-t4w4pw12	151	14	.	.	.
cord-260577-t4w4pw12	152	1	Supported	support	VBN
cord-260577-t4w4pw12	152	2	by	by	IN
cord-260577-t4w4pw12	152	3	grants	grant	NNS
cord-260577-t4w4pw12	152	4	from	from	IN
cord-260577-t4w4pw12	152	5	The	the	DT
cord-260577-t4w4pw12	152	6	National	National	NNP
cord-260577-t4w4pw12	152	7	Bank	Bank	NNP
cord-260577-t4w4pw12	152	8	of	of	IN
cord-260577-t4w4pw12	152	9	Austria	Austria	NNP
cord-260577-t4w4pw12	152	10	,	,	,
cord-260577-t4w4pw12	152	11	The	the	DT
cord-260577-t4w4pw12	152	12	Austrian	Austrian	NNP
cord-260577-t4w4pw12	152	13	Ministry	Ministry	NNP
cord-260577-t4w4pw12	152	14	of	of	IN
cord-260577-t4w4pw12	152	15	Science	Science	NNP
cord-260577-t4w4pw12	152	16	and	and	CC
cord-260577-t4w4pw12	152	17	Education	Education	NNP
cord-260577-t4w4pw12	152	18	,	,	,
cord-260577-t4w4pw12	152	19	Institute	Institute	NNP
cord-260577-t4w4pw12	152	20	of	of	IN
cord-260577-t4w4pw12	152	21	Molecular	Molecular	NNP
cord-260577-t4w4pw12	152	22	Biotechnology	Biotechnology	NNP
cord-260577-t4w4pw12	152	23	in	in	IN
cord-260577-t4w4pw12	152	24	Austrian	Austrian	NNP
cord-260577-t4w4pw12	152	25	Academy	Academy	NNP
cord-260577-t4w4pw12	152	26	of	of	IN
cord-260577-t4w4pw12	152	27	Sciences	Sciences	NNPS
cord-260577-t4w4pw12	152	28	(	(	-LRB-
cord-260577-t4w4pw12	152	29	IMBA	IMBA	NNP
cord-260577-t4w4pw12	152	30	)	)	-RRB-
cord-260577-t4w4pw12	152	31	and	and	CC
cord-260577-t4w4pw12	152	32	EUGeneHeart	EUGeneHeart	NNP
cord-260577-t4w4pw12	152	33	to	to	IN
cord-260577-t4w4pw12	152	34	J.M.P.	J.M.P.	NNP
cord-260577-t4w4pw12	152	35	K.K.	K.K.	NNP
cord-260577-t4w4pw12	152	36	is	be	VBZ
cord-260577-t4w4pw12	152	37	supported	support	VBN
cord-260577-t4w4pw12	152	38	by	by	IN
cord-260577-t4w4pw12	152	39	a	a	DT
cord-260577-t4w4pw12	152	40	Marie	Marie	NNP
cord-260577-t4w4pw12	152	41	Curie	Curie	NNP
cord-260577-t4w4pw12	152	42	Fellowship	Fellowship	NNP
cord-260577-t4w4pw12	152	43	from	from	IN
cord-260577-t4w4pw12	152	44	the	the	DT
cord-260577-t4w4pw12	152	45	EU	EU	NNP
cord-260577-t4w4pw12	152	46	.	.	.