id sid tid token lemma pos cord-317619-o7qfugjw 1 1 key key JJ cord-317619-o7qfugjw 1 2 : : : cord-317619-o7qfugjw 1 3 cord-317619-o7qfugjw cord-317619-o7qfugjw NN cord-317619-o7qfugjw 1 4 authors author NNS cord-317619-o7qfugjw 1 5 : : : cord-317619-o7qfugjw 1 6 Nye Nye NNP cord-317619-o7qfugjw 1 7 , , , cord-317619-o7qfugjw 1 8 Steven Steven NNP cord-317619-o7qfugjw 1 9 ; ; : cord-317619-o7qfugjw 1 10 Whitley Whitley NNP cord-317619-o7qfugjw 1 11 , , , cord-317619-o7qfugjw 1 12 Richard Richard NNP cord-317619-o7qfugjw 1 13 J. J. NNP cord-317619-o7qfugjw 1 14 ; ; : cord-317619-o7qfugjw 1 15 Kong Kong NNP cord-317619-o7qfugjw 1 16 , , , cord-317619-o7qfugjw 2 1 Michele Michele NNP cord-317619-o7qfugjw 2 2 title title NN cord-317619-o7qfugjw 2 3 : : : cord-317619-o7qfugjw 2 4 Viral Viral NNP cord-317619-o7qfugjw 2 5 Infection infection NN cord-317619-o7qfugjw 2 6 in in IN cord-317619-o7qfugjw 2 7 the the DT cord-317619-o7qfugjw 2 8 Development Development NNP cord-317619-o7qfugjw 2 9 and and CC cord-317619-o7qfugjw 2 10 Progression Progression NNP cord-317619-o7qfugjw 2 11 of of IN cord-317619-o7qfugjw 2 12 Pediatric Pediatric NNP cord-317619-o7qfugjw 2 13 Acute Acute NNP cord-317619-o7qfugjw 2 14 Respiratory Respiratory NNP cord-317619-o7qfugjw 2 15 Distress Distress NNP cord-317619-o7qfugjw 2 16 Syndrome Syndrome NNP cord-317619-o7qfugjw 2 17 date date NN cord-317619-o7qfugjw 2 18 : : : cord-317619-o7qfugjw 2 19 2016 2016 CD cord-317619-o7qfugjw 2 20 - - HYPH cord-317619-o7qfugjw 2 21 11 11 CD cord-317619-o7qfugjw 2 22 - - HYPH cord-317619-o7qfugjw 2 23 24 24 CD cord-317619-o7qfugjw 2 24 journal journal NN cord-317619-o7qfugjw 2 25 : : : cord-317619-o7qfugjw 3 1 Front Front NNP cord-317619-o7qfugjw 3 2 Pediatr Pediatr NNP cord-317619-o7qfugjw 3 3 DOI DOI NNP cord-317619-o7qfugjw 3 4 : : : cord-317619-o7qfugjw 3 5 10.3389/ 10.3389/ CD cord-317619-o7qfugjw 4 1 fped.2016.00128 fped.2016.00128 NNP cord-317619-o7qfugjw 4 2 sha sha NNP cord-317619-o7qfugjw 4 3 : : : cord-317619-o7qfugjw 5 1 0792384d074cef963c808eacf3c63e3654776a2a 0792384d074cef963c808eacf3c63e3654776a2a CD cord-317619-o7qfugjw 6 1 doc_id doc_id CD cord-317619-o7qfugjw 6 2 : : : cord-317619-o7qfugjw 6 3 317619 317619 CD cord-317619-o7qfugjw 6 4 cord_uid cord_uid NN cord-317619-o7qfugjw 6 5 : : : cord-317619-o7qfugjw 7 1 o7qfugjw o7qfugjw NNP cord-317619-o7qfugjw 8 1 Viral viral JJ cord-317619-o7qfugjw 8 2 infections infection NNS cord-317619-o7qfugjw 8 3 are be VBP cord-317619-o7qfugjw 8 4 an an DT cord-317619-o7qfugjw 8 5 important important JJ cord-317619-o7qfugjw 8 6 cause cause NN cord-317619-o7qfugjw 8 7 of of IN cord-317619-o7qfugjw 8 8 pediatric pediatric JJ cord-317619-o7qfugjw 8 9 acute acute JJ cord-317619-o7qfugjw 8 10 respiratory respiratory JJ cord-317619-o7qfugjw 8 11 distress distress NN cord-317619-o7qfugjw 8 12 syndrome syndrome NN cord-317619-o7qfugjw 8 13 ( ( -LRB- cord-317619-o7qfugjw 8 14 ARDS ARDS NNP cord-317619-o7qfugjw 8 15 ) ) -RRB- cord-317619-o7qfugjw 8 16 . . . cord-317619-o7qfugjw 9 1 Numerous numerous JJ cord-317619-o7qfugjw 9 2 viruses virus NNS cord-317619-o7qfugjw 9 3 , , , cord-317619-o7qfugjw 9 4 including include VBG cord-317619-o7qfugjw 9 5 respiratory respiratory JJ cord-317619-o7qfugjw 9 6 syncytial syncytial JJ cord-317619-o7qfugjw 9 7 virus virus NN cord-317619-o7qfugjw 9 8 ( ( -LRB- cord-317619-o7qfugjw 9 9 RSV RSV NNP cord-317619-o7qfugjw 9 10 ) ) -RRB- cord-317619-o7qfugjw 9 11 and and CC cord-317619-o7qfugjw 9 12 influenza influenza NN cord-317619-o7qfugjw 9 13 A a DT cord-317619-o7qfugjw 9 14 ( ( -LRB- cord-317619-o7qfugjw 9 15 H1N1 H1N1 NNP cord-317619-o7qfugjw 9 16 ) ) -RRB- cord-317619-o7qfugjw 9 17 virus virus NN cord-317619-o7qfugjw 9 18 , , , cord-317619-o7qfugjw 9 19 have have VBP cord-317619-o7qfugjw 9 20 been be VBN cord-317619-o7qfugjw 9 21 implicated implicate VBN cord-317619-o7qfugjw 9 22 in in IN cord-317619-o7qfugjw 9 23 the the DT cord-317619-o7qfugjw 9 24 progression progression NN cord-317619-o7qfugjw 9 25 of of IN cord-317619-o7qfugjw 9 26 pneumonia pneumonia NN cord-317619-o7qfugjw 9 27 to to IN cord-317619-o7qfugjw 9 28 ARDS ARDS NNP cord-317619-o7qfugjw 9 29 ; ; : cord-317619-o7qfugjw 9 30 yet yet CC cord-317619-o7qfugjw 9 31 the the DT cord-317619-o7qfugjw 9 32 incidence incidence NN cord-317619-o7qfugjw 9 33 of of IN cord-317619-o7qfugjw 9 34 progression progression NN cord-317619-o7qfugjw 9 35 is be VBZ cord-317619-o7qfugjw 9 36 unknown unknown JJ cord-317619-o7qfugjw 9 37 . . . cord-317619-o7qfugjw 10 1 Despite despite IN cord-317619-o7qfugjw 10 2 acute acute JJ cord-317619-o7qfugjw 10 3 and and CC cord-317619-o7qfugjw 10 4 chronic chronic JJ cord-317619-o7qfugjw 10 5 morbidity morbidity NN cord-317619-o7qfugjw 10 6 associated associate VBN cord-317619-o7qfugjw 10 7 with with IN cord-317619-o7qfugjw 10 8 respiratory respiratory JJ cord-317619-o7qfugjw 10 9 viral viral JJ cord-317619-o7qfugjw 10 10 infections infection NNS cord-317619-o7qfugjw 10 11 , , , cord-317619-o7qfugjw 10 12 particularly particularly RB cord-317619-o7qfugjw 10 13 in in IN cord-317619-o7qfugjw 10 14 “ " `` cord-317619-o7qfugjw 10 15 at at IN cord-317619-o7qfugjw 10 16 risk risk NN cord-317619-o7qfugjw 10 17 ” " '' cord-317619-o7qfugjw 10 18 populations population NNS cord-317619-o7qfugjw 10 19 , , , cord-317619-o7qfugjw 10 20 treatment treatment NN cord-317619-o7qfugjw 10 21 options option NNS cord-317619-o7qfugjw 10 22 are be VBP cord-317619-o7qfugjw 10 23 limited limited JJ cord-317619-o7qfugjw 10 24 . . . cord-317619-o7qfugjw 11 1 Thus thus RB cord-317619-o7qfugjw 11 2 , , , cord-317619-o7qfugjw 11 3 with with IN cord-317619-o7qfugjw 11 4 few few JJ cord-317619-o7qfugjw 11 5 exceptions exception NNS cord-317619-o7qfugjw 11 6 , , , cord-317619-o7qfugjw 11 7 care care NN cord-317619-o7qfugjw 11 8 is be VBZ cord-317619-o7qfugjw 11 9 symptomatic symptomatic JJ cord-317619-o7qfugjw 11 10 . . . cord-317619-o7qfugjw 12 1 In in IN cord-317619-o7qfugjw 12 2 addition addition NN cord-317619-o7qfugjw 12 3 , , , cord-317619-o7qfugjw 12 4 mortality mortality NN cord-317619-o7qfugjw 12 5 rates rate NNS cord-317619-o7qfugjw 12 6 for for IN cord-317619-o7qfugjw 12 7 viral viral RB cord-317619-o7qfugjw 12 8 - - HYPH cord-317619-o7qfugjw 12 9 related relate VBN cord-317619-o7qfugjw 12 10 ARDS ARDS NNP cord-317619-o7qfugjw 12 11 have have VBP cord-317619-o7qfugjw 12 12 yet yet RB cord-317619-o7qfugjw 12 13 to to TO cord-317619-o7qfugjw 12 14 be be VB cord-317619-o7qfugjw 12 15 determined determine VBN cord-317619-o7qfugjw 12 16 . . . cord-317619-o7qfugjw 13 1 This this DT cord-317619-o7qfugjw 13 2 review review NN cord-317619-o7qfugjw 13 3 outlines outline VBZ cord-317619-o7qfugjw 13 4 what what WP cord-317619-o7qfugjw 13 5 is be VBZ cord-317619-o7qfugjw 13 6 known know VBN cord-317619-o7qfugjw 13 7 about about IN cord-317619-o7qfugjw 13 8 ARDS ARDS NNP cord-317619-o7qfugjw 13 9 secondary secondary JJ cord-317619-o7qfugjw 13 10 to to IN cord-317619-o7qfugjw 13 11 viral viral JJ cord-317619-o7qfugjw 13 12 infections infection NNS cord-317619-o7qfugjw 13 13 including include VBG cord-317619-o7qfugjw 13 14 the the DT cord-317619-o7qfugjw 13 15 epidemiology epidemiology NN cord-317619-o7qfugjw 13 16 , , , cord-317619-o7qfugjw 13 17 the the DT cord-317619-o7qfugjw 13 18 pathophysiology pathophysiology NN cord-317619-o7qfugjw 13 19 , , , cord-317619-o7qfugjw 13 20 and and CC cord-317619-o7qfugjw 13 21 diagnosis diagnosis NN cord-317619-o7qfugjw 13 22 . . . cord-317619-o7qfugjw 14 1 In in IN cord-317619-o7qfugjw 14 2 addition addition NN cord-317619-o7qfugjw 14 3 , , , cord-317619-o7qfugjw 14 4 emerging emerge VBG cord-317619-o7qfugjw 14 5 treatment treatment NN cord-317619-o7qfugjw 14 6 options option NNS cord-317619-o7qfugjw 14 7 to to TO cord-317619-o7qfugjw 14 8 prevent prevent VB cord-317619-o7qfugjw 14 9 infection infection NN cord-317619-o7qfugjw 14 10 , , , cord-317619-o7qfugjw 14 11 and and CC cord-317619-o7qfugjw 14 12 to to TO cord-317619-o7qfugjw 14 13 decrease decrease VB cord-317619-o7qfugjw 14 14 disease disease NN cord-317619-o7qfugjw 14 15 burden burden NN cord-317619-o7qfugjw 14 16 will will MD cord-317619-o7qfugjw 14 17 be be VB cord-317619-o7qfugjw 14 18 outlined outline VBN cord-317619-o7qfugjw 14 19 . . . cord-317619-o7qfugjw 15 1 We -PRON- PRP cord-317619-o7qfugjw 15 2 focused focus VBD cord-317619-o7qfugjw 15 3 on on IN cord-317619-o7qfugjw 15 4 RSV RSV NNP cord-317619-o7qfugjw 15 5 and and CC cord-317619-o7qfugjw 15 6 influenza influenza NN cord-317619-o7qfugjw 15 7 A a NN cord-317619-o7qfugjw 15 8 ( ( -LRB- cord-317619-o7qfugjw 15 9 H1N1 H1N1 NNP cord-317619-o7qfugjw 15 10 ) ) -RRB- cord-317619-o7qfugjw 15 11 viral viral JJ cord-317619-o7qfugjw 15 12 - - HYPH cord-317619-o7qfugjw 15 13 induced induce VBN cord-317619-o7qfugjw 15 14 ARDS ARDS NNP cord-317619-o7qfugjw 15 15 , , , cord-317619-o7qfugjw 15 16 as as IN cord-317619-o7qfugjw 15 17 these these DT cord-317619-o7qfugjw 15 18 are be VBP cord-317619-o7qfugjw 15 19 the the DT cord-317619-o7qfugjw 15 20 most most RBS cord-317619-o7qfugjw 15 21 common common JJ cord-317619-o7qfugjw 15 22 viruses virus NNS cord-317619-o7qfugjw 15 23 leading lead VBG cord-317619-o7qfugjw 15 24 to to IN cord-317619-o7qfugjw 15 25 pediatric pediatric JJ cord-317619-o7qfugjw 15 26 ARDS ARDS NNP cord-317619-o7qfugjw 15 27 , , , cord-317619-o7qfugjw 15 28 and and CC cord-317619-o7qfugjw 15 29 have have VBP cord-317619-o7qfugjw 15 30 specific specific JJ cord-317619-o7qfugjw 15 31 prophylactic prophylactic JJ cord-317619-o7qfugjw 15 32 and and CC cord-317619-o7qfugjw 15 33 definitive definitive JJ cord-317619-o7qfugjw 15 34 treatment treatment NN cord-317619-o7qfugjw 15 35 options option NNS cord-317619-o7qfugjw 15 36 . . . cord-317619-o7qfugjw 16 1 Acute acute JJ cord-317619-o7qfugjw 16 2 respiratory respiratory JJ cord-317619-o7qfugjw 16 3 distress distress NN cord-317619-o7qfugjw 16 4 syndrome syndrome NN cord-317619-o7qfugjw 16 5 ( ( -LRB- cord-317619-o7qfugjw 16 6 ARDS ARDS NNP cord-317619-o7qfugjw 16 7 ) ) -RRB- cord-317619-o7qfugjw 16 8 was be VBD cord-317619-o7qfugjw 16 9 first first RB cord-317619-o7qfugjw 16 10 described describe VBN cord-317619-o7qfugjw 16 11 in in IN cord-317619-o7qfugjw 16 12 1967 1967 CD cord-317619-o7qfugjw 16 13 in in IN cord-317619-o7qfugjw 16 14 adults adult NNS cord-317619-o7qfugjw 16 15 presenting present VBG cord-317619-o7qfugjw 16 16 with with IN cord-317619-o7qfugjw 16 17 tachypnea tachypnea NNP cord-317619-o7qfugjw 16 18 , , , cord-317619-o7qfugjw 16 19 hypoxemia hypoxemia NN cord-317619-o7qfugjw 16 20 , , , cord-317619-o7qfugjw 16 21 and and CC cord-317619-o7qfugjw 16 22 decreased decrease VBD cord-317619-o7qfugjw 16 23 pulmonary pulmonary JJ cord-317619-o7qfugjw 16 24 compliance compliance NN cord-317619-o7qfugjw 16 25 ( ( -LRB- cord-317619-o7qfugjw 16 26 1 1 CD cord-317619-o7qfugjw 16 27 ) ) -RRB- cord-317619-o7qfugjw 16 28 . . . cord-317619-o7qfugjw 17 1 Since since IN cord-317619-o7qfugjw 17 2 then then RB cord-317619-o7qfugjw 17 3 , , , cord-317619-o7qfugjw 17 4 the the DT cord-317619-o7qfugjw 17 5 understanding understanding NN cord-317619-o7qfugjw 17 6 , , , cord-317619-o7qfugjw 17 7 diagnosis diagnosis NN cord-317619-o7qfugjw 17 8 , , , cord-317619-o7qfugjw 17 9 and and CC cord-317619-o7qfugjw 17 10 management management NN cord-317619-o7qfugjw 17 11 of of IN cord-317619-o7qfugjw 17 12 ARDS ARDS NNP cord-317619-o7qfugjw 17 13 has have VBZ cord-317619-o7qfugjw 17 14 advanced advance VBN cord-317619-o7qfugjw 17 15 greatly greatly RB cord-317619-o7qfugjw 17 16 , , , cord-317619-o7qfugjw 17 17 with with IN cord-317619-o7qfugjw 17 18 most most JJS cord-317619-o7qfugjw 17 19 research research NN cord-317619-o7qfugjw 17 20 performed perform VBN cord-317619-o7qfugjw 17 21 in in IN cord-317619-o7qfugjw 17 22 adults adult NNS cord-317619-o7qfugjw 17 23 . . . cord-317619-o7qfugjw 18 1 For for IN cord-317619-o7qfugjw 18 2 more more JJR cord-317619-o7qfugjw 18 3 than than IN cord-317619-o7qfugjw 18 4 two two CD cord-317619-o7qfugjw 18 5 decades decade NNS cord-317619-o7qfugjw 18 6 , , , cord-317619-o7qfugjw 18 7 pediatric pediatric JJ cord-317619-o7qfugjw 18 8 health health NN cord-317619-o7qfugjw 18 9 - - HYPH cord-317619-o7qfugjw 18 10 care care NN cord-317619-o7qfugjw 18 11 providers provider NNS cord-317619-o7qfugjw 18 12 have have VBP cord-317619-o7qfugjw 18 13 relied rely VBN cord-317619-o7qfugjw 18 14 heavily heavily RB cord-317619-o7qfugjw 18 15 on on IN cord-317619-o7qfugjw 18 16 adult adult NN cord-317619-o7qfugjw 18 17 - - HYPH cord-317619-o7qfugjw 18 18 derived derive VBN cord-317619-o7qfugjw 18 19 diagnostic diagnostic JJ cord-317619-o7qfugjw 18 20 criteria criterion NNS cord-317619-o7qfugjw 18 21 ( ( -LRB- cord-317619-o7qfugjw 18 22 2 2 CD cord-317619-o7qfugjw 18 23 , , , cord-317619-o7qfugjw 18 24 3 3 CD cord-317619-o7qfugjw 18 25 ) ) -RRB- cord-317619-o7qfugjw 18 26 . . . cord-317619-o7qfugjw 19 1 In in IN cord-317619-o7qfugjw 19 2 recent recent JJ cord-317619-o7qfugjw 19 3 years year NNS cord-317619-o7qfugjw 19 4 , , , cord-317619-o7qfugjw 19 5 the the DT cord-317619-o7qfugjw 19 6 Pediatric Pediatric NNP cord-317619-o7qfugjw 19 7 Acute Acute NNP cord-317619-o7qfugjw 19 8 Lung Lung NNP cord-317619-o7qfugjw 19 9 Injury Injury NNP cord-317619-o7qfugjw 19 10 Consensus Consensus NNP cord-317619-o7qfugjw 19 11 Conference Conference NNP cord-317619-o7qfugjw 19 12 ( ( -LRB- cord-317619-o7qfugjw 19 13 PALICC PALICC NNP cord-317619-o7qfugjw 19 14 ) ) -RRB- cord-317619-o7qfugjw 19 15 has have VBZ cord-317619-o7qfugjw 19 16 provided provide VBN cord-317619-o7qfugjw 19 17 age age NN cord-317619-o7qfugjw 19 18 - - HYPH cord-317619-o7qfugjw 19 19 specific specific JJ cord-317619-o7qfugjw 19 20 diagnostic diagnostic JJ cord-317619-o7qfugjw 19 21 and and CC cord-317619-o7qfugjw 19 22 management management NN cord-317619-o7qfugjw 19 23 guidelines guideline NNS cord-317619-o7qfugjw 19 24 for for IN cord-317619-o7qfugjw 19 25 pediatric pediatric JJ cord-317619-o7qfugjw 19 26 ARDS ARDS NNP cord-317619-o7qfugjw 19 27 ( ( -LRB- cord-317619-o7qfugjw 19 28 4 4 CD cord-317619-o7qfugjw 19 29 , , , cord-317619-o7qfugjw 19 30 5 5 CD cord-317619-o7qfugjw 19 31 ) ) -RRB- cord-317619-o7qfugjw 19 32 . . . cord-317619-o7qfugjw 20 1 With with IN cord-317619-o7qfugjw 20 2 these these DT cord-317619-o7qfugjw 20 3 new new JJ cord-317619-o7qfugjw 20 4 pediatric pediatric JJ cord-317619-o7qfugjw 20 5 - - HYPH cord-317619-o7qfugjw 20 6 specific specific JJ cord-317619-o7qfugjw 20 7 recommendations recommendation NNS cord-317619-o7qfugjw 20 8 , , , cord-317619-o7qfugjw 20 9 future future JJ cord-317619-o7qfugjw 20 10 research research NN cord-317619-o7qfugjw 20 11 in in IN cord-317619-o7qfugjw 20 12 pediatric pediatric JJ cord-317619-o7qfugjw 20 13 ARDS ARDS NNP cord-317619-o7qfugjw 20 14 looks look VBZ cord-317619-o7qfugjw 20 15 promising promise VBG cord-317619-o7qfugjw 20 16 , , , cord-317619-o7qfugjw 20 17 as as IN cord-317619-o7qfugjw 20 18 new new JJ cord-317619-o7qfugjw 20 19 areas area NNS cord-317619-o7qfugjw 20 20 for for IN cord-317619-o7qfugjw 20 21 investigation investigation NN cord-317619-o7qfugjw 20 22 have have VBP cord-317619-o7qfugjw 20 23 been be VBN cord-317619-o7qfugjw 20 24 identified identify VBN cord-317619-o7qfugjw 20 25 ( ( -LRB- cord-317619-o7qfugjw 20 26 5 5 CD cord-317619-o7qfugjw 20 27 ) ) -RRB- cord-317619-o7qfugjw 20 28 . . . cord-317619-o7qfugjw 21 1 One one CD cord-317619-o7qfugjw 21 2 area area NN cord-317619-o7qfugjw 21 3 of of IN cord-317619-o7qfugjw 21 4 interest interest NN cord-317619-o7qfugjw 21 5 warranting warrant VBG cord-317619-o7qfugjw 21 6 further further JJ cord-317619-o7qfugjw 21 7 exploration exploration NN cord-317619-o7qfugjw 21 8 is be VBZ cord-317619-o7qfugjw 21 9 the the DT cord-317619-o7qfugjw 21 10 role role NN cord-317619-o7qfugjw 21 11 of of IN cord-317619-o7qfugjw 21 12 viral viral JJ cord-317619-o7qfugjw 21 13 infection infection NN cord-317619-o7qfugjw 21 14 in in IN cord-317619-o7qfugjw 21 15 the the DT cord-317619-o7qfugjw 21 16 development development NN cord-317619-o7qfugjw 21 17 and and CC cord-317619-o7qfugjw 21 18 progression progression NN cord-317619-o7qfugjw 21 19 of of IN cord-317619-o7qfugjw 21 20 pediatric pediatric JJ cord-317619-o7qfugjw 21 21 ARDS ARDS NNP cord-317619-o7qfugjw 21 22 . . . cord-317619-o7qfugjw 22 1 While while IN cord-317619-o7qfugjw 22 2 some some DT cord-317619-o7qfugjw 22 3 information information NN cord-317619-o7qfugjw 22 4 is be VBZ cord-317619-o7qfugjw 22 5 available available JJ cord-317619-o7qfugjw 22 6 specific specific JJ cord-317619-o7qfugjw 22 7 to to IN cord-317619-o7qfugjw 22 8 pediatrics pediatric NNS cord-317619-o7qfugjw 22 9 , , , cord-317619-o7qfugjw 22 10 much much JJ cord-317619-o7qfugjw 22 11 of of IN cord-317619-o7qfugjw 22 12 our -PRON- PRP$ cord-317619-o7qfugjw 22 13 understanding understanding NN cord-317619-o7qfugjw 22 14 continues continue VBZ cord-317619-o7qfugjw 22 15 to to TO cord-317619-o7qfugjw 22 16 be be VB cord-317619-o7qfugjw 22 17 derivative derivative JJ cord-317619-o7qfugjw 22 18 from from IN cord-317619-o7qfugjw 22 19 adult adult NN cord-317619-o7qfugjw 22 20 data datum NNS cord-317619-o7qfugjw 22 21 . . . cord-317619-o7qfugjw 23 1 This this DT cord-317619-o7qfugjw 23 2 review review NN cord-317619-o7qfugjw 23 3 outlines outline VBZ cord-317619-o7qfugjw 23 4 what what WP cord-317619-o7qfugjw 23 5 is be VBZ cord-317619-o7qfugjw 23 6 known know VBN cord-317619-o7qfugjw 23 7 about about IN cord-317619-o7qfugjw 23 8 ARDS ARDS NNP cord-317619-o7qfugjw 23 9 attributable attributable JJ cord-317619-o7qfugjw 23 10 to to IN cord-317619-o7qfugjw 23 11 viral viral JJ cord-317619-o7qfugjw 23 12 infections infection NNS cord-317619-o7qfugjw 23 13 , , , cord-317619-o7qfugjw 23 14 specifically specifically RB cord-317619-o7qfugjw 23 15 respiratory respiratory JJ cord-317619-o7qfugjw 23 16 syncytial syncytial JJ cord-317619-o7qfugjw 23 17 virus virus NN cord-317619-o7qfugjw 23 18 ( ( -LRB- cord-317619-o7qfugjw 23 19 RSV RSV NNP cord-317619-o7qfugjw 23 20 ) ) -RRB- cord-317619-o7qfugjw 23 21 and and CC cord-317619-o7qfugjw 23 22 influenza influenza NN cord-317619-o7qfugjw 23 23 A a DT cord-317619-o7qfugjw 23 24 ( ( -LRB- cord-317619-o7qfugjw 23 25 H1N1 H1N1 NNP cord-317619-o7qfugjw 23 26 ) ) -RRB- cord-317619-o7qfugjw 23 27 virus virus NN cord-317619-o7qfugjw 23 28 , , , cord-317619-o7qfugjw 23 29 as as RB cord-317619-o7qfugjw 23 30 well well RB cord-317619-o7qfugjw 23 31 as as IN cord-317619-o7qfugjw 23 32 viral viral JJ cord-317619-o7qfugjw 23 33 - - HYPH cord-317619-o7qfugjw 23 34 specific specific JJ cord-317619-o7qfugjw 23 35 treatment treatment NN cord-317619-o7qfugjw 23 36 options option NNS cord-317619-o7qfugjw 23 37 . . . cord-317619-o7qfugjw 24 1 ePiDeMiOLOGY ePiDeMiOLOGY NNP cord-317619-o7qfugjw 24 2 OF of IN cord-317619-o7qfugjw 24 3 RSv RSv NNS cord-317619-o7qfugjw 24 4 AND and CC cord-317619-o7qfugjw 24 5 iNFLUeNZA iNFLUeNZA NNP cord-317619-o7qfugjw 24 6 - - HYPH cord-317619-o7qfugjw 24 7 iNDUCeD iNDUCeD NNP cord-317619-o7qfugjw 24 8 ARDS ARDS NNP cord-317619-o7qfugjw 25 1 Accurate accurate JJ cord-317619-o7qfugjw 25 2 incidence incidence NN cord-317619-o7qfugjw 25 3 outcomes outcome NNS cord-317619-o7qfugjw 25 4 reporting report VBG cord-317619-o7qfugjw 25 5 for for IN cord-317619-o7qfugjw 25 6 pediatric pediatric JJ cord-317619-o7qfugjw 25 7 ARDS ARDS NNP cord-317619-o7qfugjw 25 8 are be VBP cord-317619-o7qfugjw 25 9 limited limit VBN cord-317619-o7qfugjw 25 10 by by IN cord-317619-o7qfugjw 25 11 the the DT cord-317619-o7qfugjw 25 12 changing change VBG cord-317619-o7qfugjw 25 13 definition definition NN cord-317619-o7qfugjw 25 14 for for IN cord-317619-o7qfugjw 25 15 ARDS ARDS NNP cord-317619-o7qfugjw 25 16 . . . cord-317619-o7qfugjw 26 1 Studies study NNS cord-317619-o7qfugjw 26 2 using use VBG cord-317619-o7qfugjw 26 3 the the DT cord-317619-o7qfugjw 26 4 1994 1994 CD cord-317619-o7qfugjw 26 5 American American NNP cord-317619-o7qfugjw 26 6 European European NNP cord-317619-o7qfugjw 26 7 Consensus Consensus NNP cord-317619-o7qfugjw 26 8 Conference Conference NNP cord-317619-o7qfugjw 26 9 ( ( -LRB- cord-317619-o7qfugjw 26 10 AECC AECC NNP cord-317619-o7qfugjw 26 11 ) ) -RRB- cord-317619-o7qfugjw 26 12 definition definition NN cord-317619-o7qfugjw 26 13 ( ( -LRB- cord-317619-o7qfugjw 26 14 2 2 CD cord-317619-o7qfugjw 26 15 ) ) -RRB- cord-317619-o7qfugjw 26 16 outlined outline VBD cord-317619-o7qfugjw 26 17 epidemiology epidemiology NN cord-317619-o7qfugjw 26 18 and and CC cord-317619-o7qfugjw 26 19 outcomes outcome NNS cord-317619-o7qfugjw 26 20 for for IN cord-317619-o7qfugjw 26 21 both both DT cord-317619-o7qfugjw 26 22 acute acute JJ cord-317619-o7qfugjw 26 23 lung lung NN cord-317619-o7qfugjw 26 24 injury injury NN cord-317619-o7qfugjw 26 25 ( ( -LRB- cord-317619-o7qfugjw 26 26 ALI ALI NNP cord-317619-o7qfugjw 26 27 ) ) -RRB- cord-317619-o7qfugjw 26 28 and and CC cord-317619-o7qfugjw 26 29 ARDS ARDS NNP cord-317619-o7qfugjw 26 30 as as IN cord-317619-o7qfugjw 26 31 separate separate JJ cord-317619-o7qfugjw 26 32 Viral Viral NNP cord-317619-o7qfugjw 26 33 Infection Infection NNP cord-317619-o7qfugjw 26 34 and and CC cord-317619-o7qfugjw 26 35 Pediatric Pediatric NNP cord-317619-o7qfugjw 26 36 ARDS ARDS NNP cord-317619-o7qfugjw 26 37 Frontiers Frontiers NNPS cord-317619-o7qfugjw 26 38 in in IN cord-317619-o7qfugjw 26 39 Pediatrics Pediatrics NNP cord-317619-o7qfugjw 26 40 | | NNP cord-317619-o7qfugjw 26 41 www.frontiersin.org www.frontiersin.org IN cord-317619-o7qfugjw 26 42 November November NNP cord-317619-o7qfugjw 26 43 2016 2016 CD cord-317619-o7qfugjw 26 44 | | NNP cord-317619-o7qfugjw 26 45 Volume Volume NNP cord-317619-o7qfugjw 26 46 4 4 CD cord-317619-o7qfugjw 26 47 | | NNP cord-317619-o7qfugjw 26 48 Article Article NNP cord-317619-o7qfugjw 26 49 128 128 CD cord-317619-o7qfugjw 26 50 entities entity NNS cord-317619-o7qfugjw 26 51 ( ( -LRB- cord-317619-o7qfugjw 26 52 6 6 CD cord-317619-o7qfugjw 26 53 ) ) -RRB- cord-317619-o7qfugjw 26 54 . . . cord-317619-o7qfugjw 27 1 However however RB cord-317619-o7qfugjw 27 2 , , , cord-317619-o7qfugjw 27 3 both both CC cord-317619-o7qfugjw 27 4 the the DT cord-317619-o7qfugjw 27 5 Berlin Berlin NNP cord-317619-o7qfugjw 27 6 definition definition NN cord-317619-o7qfugjw 27 7 ( ( -LRB- cord-317619-o7qfugjw 27 8 3 3 CD cord-317619-o7qfugjw 27 9 ) ) -RRB- cord-317619-o7qfugjw 27 10 and and CC cord-317619-o7qfugjw 27 11 the the DT cord-317619-o7qfugjw 27 12 PALICC PALICC NNP cord-317619-o7qfugjw 27 13 recommendations recommendation NNS cord-317619-o7qfugjw 27 14 ( ( -LRB- cord-317619-o7qfugjw 27 15 5 5 LS cord-317619-o7qfugjw 27 16 ) ) -RRB- cord-317619-o7qfugjw 27 17 no no RB cord-317619-o7qfugjw 27 18 longer longer RB cord-317619-o7qfugjw 27 19 identify identify VB cord-317619-o7qfugjw 27 20 ALI ALI NNP cord-317619-o7qfugjw 27 21 as as IN cord-317619-o7qfugjw 27 22 a a DT cord-317619-o7qfugjw 27 23 separate separate JJ cord-317619-o7qfugjw 27 24 entity entity NN cord-317619-o7qfugjw 27 25 , , , cord-317619-o7qfugjw 27 26 instead instead RB cord-317619-o7qfugjw 27 27 categorizing categorize VBG cord-317619-o7qfugjw 27 28 ARDS ARDS NNP cord-317619-o7qfugjw 27 29 as as IN cord-317619-o7qfugjw 27 30 mild mild JJ cord-317619-o7qfugjw 27 31 , , , cord-317619-o7qfugjw 27 32 moderate moderate JJ cord-317619-o7qfugjw 27 33 , , , cord-317619-o7qfugjw 27 34 or or CC cord-317619-o7qfugjw 27 35 severe severe JJ cord-317619-o7qfugjw 27 36 . . . cord-317619-o7qfugjw 28 1 Since since IN cord-317619-o7qfugjw 28 2 these these DT cord-317619-o7qfugjw 28 3 guidelines guideline NNS cord-317619-o7qfugjw 28 4 are be VBP cord-317619-o7qfugjw 28 5 recent recent JJ cord-317619-o7qfugjw 28 6 , , , cord-317619-o7qfugjw 28 7 few few JJ cord-317619-o7qfugjw 28 8 studies study NNS cord-317619-o7qfugjw 28 9 have have VBP cord-317619-o7qfugjw 28 10 been be VBN cord-317619-o7qfugjw 28 11 conducted conduct VBN cord-317619-o7qfugjw 28 12 to to TO cord-317619-o7qfugjw 28 13 determine determine VB cord-317619-o7qfugjw 28 14 the the DT cord-317619-o7qfugjw 28 15 incidence incidence NN cord-317619-o7qfugjw 28 16 of of IN cord-317619-o7qfugjw 28 17 ARDS ARDS NNP cord-317619-o7qfugjw 28 18 utilizing utilize VBG cord-317619-o7qfugjw 28 19 these these DT cord-317619-o7qfugjw 28 20 new new JJ cord-317619-o7qfugjw 28 21 criteria criterion NNS cord-317619-o7qfugjw 28 22 ( ( -LRB- cord-317619-o7qfugjw 28 23 7 7 CD cord-317619-o7qfugjw 28 24 , , , cord-317619-o7qfugjw 28 25 8) 8) NN cord-317619-o7qfugjw 28 26 . . . cord-317619-o7qfugjw 29 1 In in IN cord-317619-o7qfugjw 29 2 addition addition NN cord-317619-o7qfugjw 29 3 , , , cord-317619-o7qfugjw 29 4 management management NN cord-317619-o7qfugjw 29 5 for for IN cord-317619-o7qfugjw 29 6 ARDS ARDS NNP cord-317619-o7qfugjw 29 7 has have VBZ cord-317619-o7qfugjw 29 8 also also RB cord-317619-o7qfugjw 29 9 changed change VBN cord-317619-o7qfugjw 29 10 over over IN cord-317619-o7qfugjw 29 11 the the DT cord-317619-o7qfugjw 29 12 years year NNS cord-317619-o7qfugjw 29 13 , , , cord-317619-o7qfugjw 29 14 with with IN cord-317619-o7qfugjw 29 15 improved improve VBN cord-317619-o7qfugjw 29 16 outcomes outcome NNS cord-317619-o7qfugjw 29 17 demonstrated demonstrate VBN cord-317619-o7qfugjw 29 18 with with IN cord-317619-o7qfugjw 29 19 lung lung NN cord-317619-o7qfugjw 29 20 - - HYPH cord-317619-o7qfugjw 29 21 protective protective JJ cord-317619-o7qfugjw 29 22 mechanical mechanical JJ cord-317619-o7qfugjw 29 23 ventilation ventilation NN cord-317619-o7qfugjw 29 24 strategies strategy NNS cord-317619-o7qfugjw 29 25 ( ( -LRB- cord-317619-o7qfugjw 29 26 9 9 CD cord-317619-o7qfugjw 29 27 , , , cord-317619-o7qfugjw 29 28 10 10 CD cord-317619-o7qfugjw 29 29 ) ) -RRB- cord-317619-o7qfugjw 29 30 . . . cord-317619-o7qfugjw 30 1 Pediatric pediatric JJ cord-317619-o7qfugjw 30 2 studies study NNS cord-317619-o7qfugjw 30 3 conducted conduct VBN cord-317619-o7qfugjw 30 4 using use VBG cord-317619-o7qfugjw 30 5 the the DT cord-317619-o7qfugjw 30 6 AECC AECC NNP cord-317619-o7qfugjw 30 7 definition definition NN cord-317619-o7qfugjw 30 8 define define VB cord-317619-o7qfugjw 30 9 an an DT cord-317619-o7qfugjw 30 10 incidence incidence NN cord-317619-o7qfugjw 30 11 ranging range VBG cord-317619-o7qfugjw 30 12 from from IN cord-317619-o7qfugjw 30 13 2.96 2.96 CD cord-317619-o7qfugjw 30 14 to to IN cord-317619-o7qfugjw 30 15 12.8 12.8 CD cord-317619-o7qfugjw 30 16 per per IN cord-317619-o7qfugjw 30 17 100,000 100,000 CD cord-317619-o7qfugjw 30 18 children child NNS cord-317619-o7qfugjw 30 19 for for IN cord-317619-o7qfugjw 30 20 all all DT cord-317619-o7qfugjw 30 21 causes cause NNS cord-317619-o7qfugjw 30 22 of of IN cord-317619-o7qfugjw 30 23 ALI ALI NNP cord-317619-o7qfugjw 30 24 / / SYM cord-317619-o7qfugjw 30 25 ARDS ARDS NNP cord-317619-o7qfugjw 30 26 , , , cord-317619-o7qfugjw 30 27 with with IN cord-317619-o7qfugjw 30 28 the the DT cord-317619-o7qfugjw 30 29 predominant predominant JJ cord-317619-o7qfugjw 30 30 etiology etiology NN cord-317619-o7qfugjw 30 31 reported report VBN cord-317619-o7qfugjw 30 32 to to TO cord-317619-o7qfugjw 30 33 be be VB cord-317619-o7qfugjw 30 34 secondary secondary JJ cord-317619-o7qfugjw 30 35 to to IN cord-317619-o7qfugjw 30 36 pneumonia pneumonia NN cord-317619-o7qfugjw 30 37 , , , cord-317619-o7qfugjw 30 38 with with IN cord-317619-o7qfugjw 30 39 or or CC cord-317619-o7qfugjw 30 40 without without IN cord-317619-o7qfugjw 30 41 systemic systemic JJ cord-317619-o7qfugjw 30 42 infection infection NN cord-317619-o7qfugjw 30 43 ( ( -LRB- cord-317619-o7qfugjw 30 44 11 11 CD cord-317619-o7qfugjw 30 45 ) ) -RRB- cord-317619-o7qfugjw 30 46 . . . cord-317619-o7qfugjw 31 1 In in IN cord-317619-o7qfugjw 31 2 a a DT cord-317619-o7qfugjw 31 3 more more RBR cord-317619-o7qfugjw 31 4 recent recent JJ cord-317619-o7qfugjw 31 5 study study NN cord-317619-o7qfugjw 31 6 , , , cord-317619-o7qfugjw 31 7 using use VBG cord-317619-o7qfugjw 31 8 the the DT cord-317619-o7qfugjw 31 9 Berlin Berlin NNP cord-317619-o7qfugjw 31 10 definition definition NN cord-317619-o7qfugjw 31 11 , , , cord-317619-o7qfugjw 31 12 Barreira Barreira NNP cord-317619-o7qfugjw 31 13 et et NNP cord-317619-o7qfugjw 31 14 al al NNP cord-317619-o7qfugjw 31 15 . . NNP cord-317619-o7qfugjw 31 16 reported report VBD cord-317619-o7qfugjw 31 17 that that IN cord-317619-o7qfugjw 31 18 ARDS ARDS NNP cord-317619-o7qfugjw 31 19 accounts account VBZ cord-317619-o7qfugjw 31 20 for for IN cord-317619-o7qfugjw 31 21 10 10 CD cord-317619-o7qfugjw 31 22 % % NN cord-317619-o7qfugjw 31 23 of of IN cord-317619-o7qfugjw 31 24 all all DT cord-317619-o7qfugjw 31 25 PICU PICU NNP cord-317619-o7qfugjw 31 26 admissions admission NNS cord-317619-o7qfugjw 31 27 , , , cord-317619-o7qfugjw 31 28 and and CC cord-317619-o7qfugjw 31 29 was be VBD cord-317619-o7qfugjw 31 30 associated associate VBN cord-317619-o7qfugjw 31 31 with with IN cord-317619-o7qfugjw 31 32 a a DT cord-317619-o7qfugjw 31 33 high high JJ cord-317619-o7qfugjw 31 34 mortality mortality NN cord-317619-o7qfugjw 31 35 rate rate NN cord-317619-o7qfugjw 31 36 of of IN cord-317619-o7qfugjw 31 37 24.5 24.5 CD cord-317619-o7qfugjw 31 38 % % NN cord-317619-o7qfugjw 31 39 ( ( -LRB- cord-317619-o7qfugjw 31 40 7 7 CD cord-317619-o7qfugjw 31 41 ) ) -RRB- cord-317619-o7qfugjw 31 42 . . . cord-317619-o7qfugjw 32 1 While while IN cord-317619-o7qfugjw 32 2 the the DT cord-317619-o7qfugjw 32 3 overall overall JJ cord-317619-o7qfugjw 32 4 incidence incidence NN cord-317619-o7qfugjw 32 5 of of IN cord-317619-o7qfugjw 32 6 respiratory respiratory JJ cord-317619-o7qfugjw 32 7 virus virus NN cord-317619-o7qfugjw 32 8 infection infection NN cord-317619-o7qfugjw 32 9 , , , cord-317619-o7qfugjw 32 10 in in IN cord-317619-o7qfugjw 32 11 particular particular JJ cord-317619-o7qfugjw 32 12 RSV RSV NNP cord-317619-o7qfugjw 32 13 and and CC cord-317619-o7qfugjw 32 14 influenza influenza NN cord-317619-o7qfugjw 32 15 A a NN cord-317619-o7qfugjw 32 16 ( ( -LRB- cord-317619-o7qfugjw 32 17 H1N1 H1N1 NNP cord-317619-o7qfugjw 32 18 ) ) -RRB- cord-317619-o7qfugjw 32 19 virus virus NN cord-317619-o7qfugjw 32 20 , , , cord-317619-o7qfugjw 32 21 leading lead VBG cord-317619-o7qfugjw 32 22 to to IN cord-317619-o7qfugjw 32 23 lower low JJR cord-317619-o7qfugjw 32 24 respiratory respiratory JJ cord-317619-o7qfugjw 32 25 tract tract NN cord-317619-o7qfugjw 32 26 disease disease NN cord-317619-o7qfugjw 32 27 is be VBZ cord-317619-o7qfugjw 32 28 widely widely RB cord-317619-o7qfugjw 32 29 studied study VBN cord-317619-o7qfugjw 32 30 ( ( -LRB- cord-317619-o7qfugjw 32 31 12 12 CD cord-317619-o7qfugjw 32 32 , , , cord-317619-o7qfugjw 32 33 13 13 CD cord-317619-o7qfugjw 32 34 ) ) -RRB- cord-317619-o7qfugjw 32 35 , , , cord-317619-o7qfugjw 32 36 the the DT cord-317619-o7qfugjw 32 37 frequency frequency NN cord-317619-o7qfugjw 32 38 of of IN cord-317619-o7qfugjw 32 39 progression progression NN cord-317619-o7qfugjw 32 40 to to IN cord-317619-o7qfugjw 32 41 pediatric pediatric JJ cord-317619-o7qfugjw 32 42 ARDS ARDS NNP cord-317619-o7qfugjw 32 43 has have VBZ cord-317619-o7qfugjw 32 44 yet yet RB cord-317619-o7qfugjw 32 45 to to TO cord-317619-o7qfugjw 32 46 be be VB cord-317619-o7qfugjw 32 47 clearly clearly RB cord-317619-o7qfugjw 32 48 determined determine VBN cord-317619-o7qfugjw 32 49 . . . cord-317619-o7qfugjw 33 1 Respiratory respiratory JJ cord-317619-o7qfugjw 33 2 syncytial syncytial JJ cord-317619-o7qfugjw 33 3 virus virus NN cord-317619-o7qfugjw 33 4 infection infection NN cord-317619-o7qfugjw 33 5 has have VBZ cord-317619-o7qfugjw 33 6 been be VBN cord-317619-o7qfugjw 33 7 recognized recognize VBN cord-317619-o7qfugjw 33 8 as as IN cord-317619-o7qfugjw 33 9 an an DT cord-317619-o7qfugjw 33 10 important important JJ cord-317619-o7qfugjw 33 11 cause cause NN cord-317619-o7qfugjw 33 12 of of IN cord-317619-o7qfugjw 33 13 lower low JJR cord-317619-o7qfugjw 33 14 lung lung NN cord-317619-o7qfugjw 33 15 disease disease NN cord-317619-o7qfugjw 33 16 . . . cord-317619-o7qfugjw 34 1 In in IN cord-317619-o7qfugjw 34 2 an an DT cord-317619-o7qfugjw 34 3 earlier early JJR cord-317619-o7qfugjw 34 4 study study NN cord-317619-o7qfugjw 34 5 , , , cord-317619-o7qfugjw 34 6 Dahlem Dahlem NNP cord-317619-o7qfugjw 34 7 et et NNP cord-317619-o7qfugjw 34 8 al al NNP cord-317619-o7qfugjw 34 9 . . NNP cord-317619-o7qfugjw 34 10 reported report VBD cord-317619-o7qfugjw 34 11 15.9 15.9 CD cord-317619-o7qfugjw 34 12 % % NN cord-317619-o7qfugjw 34 13 of of IN cord-317619-o7qfugjw 34 14 ARDS ARDS NNP cord-317619-o7qfugjw 34 15 cases case NNS cord-317619-o7qfugjw 34 16 due due JJ cord-317619-o7qfugjw 34 17 to to IN cord-317619-o7qfugjw 34 18 RSV RSV NNP cord-317619-o7qfugjw 34 19 - - HYPH cord-317619-o7qfugjw 34 20 related relate VBN cord-317619-o7qfugjw 34 21 infection infection NN cord-317619-o7qfugjw 34 22 , , , cord-317619-o7qfugjw 34 23 but but CC cord-317619-o7qfugjw 34 24 specific specific JJ cord-317619-o7qfugjw 34 25 mortality mortality NN cord-317619-o7qfugjw 34 26 for for IN cord-317619-o7qfugjw 34 27 this this DT cord-317619-o7qfugjw 34 28 group group NN cord-317619-o7qfugjw 34 29 was be VBD cord-317619-o7qfugjw 34 30 not not RB cord-317619-o7qfugjw 34 31 reported report VBN cord-317619-o7qfugjw 34 32 ( ( -LRB- cord-317619-o7qfugjw 34 33 14 14 CD cord-317619-o7qfugjw 34 34 ) ) -RRB- cord-317619-o7qfugjw 34 35 . . . cord-317619-o7qfugjw 35 1 In in IN cord-317619-o7qfugjw 35 2 a a DT cord-317619-o7qfugjw 35 3 more more RBR cord-317619-o7qfugjw 35 4 recent recent JJ cord-317619-o7qfugjw 35 5 study study NN cord-317619-o7qfugjw 35 6 by by IN cord-317619-o7qfugjw 35 7 19 19 CD cord-317619-o7qfugjw 35 8 .8 .8 CD cord-317619-o7qfugjw 35 9 % % NN cord-317619-o7qfugjw 35 10 of of IN cord-317619-o7qfugjw 35 11 patients patient NNS cord-317619-o7qfugjw 35 12 admitted admit VBN cord-317619-o7qfugjw 35 13 to to IN cord-317619-o7qfugjw 35 14 the the DT cord-317619-o7qfugjw 35 15 PICU PICU NNP cord-317619-o7qfugjw 35 16 with with IN cord-317619-o7qfugjw 35 17 ARDS ARDS NNP cord-317619-o7qfugjw 35 18 tested test VBD cord-317619-o7qfugjw 35 19 positive positive JJ cord-317619-o7qfugjw 35 20 for for IN cord-317619-o7qfugjw 35 21 RSV RSV NNP cord-317619-o7qfugjw 35 22 , , , cord-317619-o7qfugjw 35 23 with with IN cord-317619-o7qfugjw 35 24 a a DT cord-317619-o7qfugjw 35 25 reported report VBN cord-317619-o7qfugjw 35 26 mortality mortality NN cord-317619-o7qfugjw 35 27 of of IN cord-317619-o7qfugjw 35 28 13.7 13.7 CD cord-317619-o7qfugjw 35 29 % % NN cord-317619-o7qfugjw 35 30 ( ( -LRB- cord-317619-o7qfugjw 35 31 15 15 CD cord-317619-o7qfugjw 35 32 ) ) -RRB- cord-317619-o7qfugjw 35 33 . . . cord-317619-o7qfugjw 36 1 A a DT cord-317619-o7qfugjw 36 2 12-year 12-year JJ cord-317619-o7qfugjw 36 3 study study NN cord-317619-o7qfugjw 36 4 in in IN cord-317619-o7qfugjw 36 5 the the DT cord-317619-o7qfugjw 36 6 Netherlands Netherlands NNP cord-317619-o7qfugjw 36 7 by by IN cord-317619-o7qfugjw 36 8 Schene Schene NNP cord-317619-o7qfugjw 36 9 et et NNP cord-317619-o7qfugjw 36 10 al al NNP cord-317619-o7qfugjw 36 11 . . . cord-317619-o7qfugjw 37 1 analyzed analyze VBN cord-317619-o7qfugjw 37 2 155 155 CD cord-317619-o7qfugjw 37 3 patients patient NNS cord-317619-o7qfugjw 37 4 mechanically mechanically RB cord-317619-o7qfugjw 37 5 ventilated ventilate VBN cord-317619-o7qfugjw 37 6 for for IN cord-317619-o7qfugjw 37 7 RSV RSV NNP cord-317619-o7qfugjw 37 8 with with IN cord-317619-o7qfugjw 37 9 129 129 CD cord-317619-o7qfugjw 37 10 ( ( -LRB- cord-317619-o7qfugjw 37 11 83 83 CD cord-317619-o7qfugjw 37 12 % % NN cord-317619-o7qfugjw 37 13 ) ) -RRB- cord-317619-o7qfugjw 37 14 patients patient NNS cord-317619-o7qfugjw 37 15 progressing progress VBG cord-317619-o7qfugjw 37 16 to to IN cord-317619-o7qfugjw 37 17 ARDS ARDS NNP cord-317619-o7qfugjw 37 18 ( ( -LRB- cord-317619-o7qfugjw 37 19 16 16 CD cord-317619-o7qfugjw 37 20 ) ) -RRB- cord-317619-o7qfugjw 37 21 . . . cord-317619-o7qfugjw 38 1 Of of IN cord-317619-o7qfugjw 38 2 those those DT cord-317619-o7qfugjw 38 3 with with IN cord-317619-o7qfugjw 38 4 ARDS ARDS NNP cord-317619-o7qfugjw 38 5 , , , cord-317619-o7qfugjw 38 6 38 38 CD cord-317619-o7qfugjw 38 7 % % NN cord-317619-o7qfugjw 38 8 were be VBD cord-317619-o7qfugjw 38 9 found find VBN cord-317619-o7qfugjw 38 10 to to TO cord-317619-o7qfugjw 38 11 have have VB cord-317619-o7qfugjw 38 12 a a DT cord-317619-o7qfugjw 38 13 bacterial bacterial JJ cord-317619-o7qfugjw 38 14 coinfection coinfection NN cord-317619-o7qfugjw 38 15 . . . cord-317619-o7qfugjw 39 1 The the DT cord-317619-o7qfugjw 39 2 mortality mortality NN cord-317619-o7qfugjw 39 3 rate rate NN cord-317619-o7qfugjw 39 4 was be VBD cord-317619-o7qfugjw 39 5 not not RB cord-317619-o7qfugjw 39 6 used use VBN cord-317619-o7qfugjw 39 7 as as IN cord-317619-o7qfugjw 39 8 a a DT cord-317619-o7qfugjw 39 9 measure measure NN cord-317619-o7qfugjw 39 10 of of IN cord-317619-o7qfugjw 39 11 outcome outcome NN cord-317619-o7qfugjw 39 12 and and CC cord-317619-o7qfugjw 39 13 therefore therefore RB cord-317619-o7qfugjw 39 14 not not RB cord-317619-o7qfugjw 39 15 reported report VBN cord-317619-o7qfugjw 39 16 . . . cord-317619-o7qfugjw 40 1 Since since IN cord-317619-o7qfugjw 40 2 the the DT cord-317619-o7qfugjw 40 3 beginning beginning NN cord-317619-o7qfugjw 40 4 of of IN cord-317619-o7qfugjw 40 5 the the DT cord-317619-o7qfugjw 40 6 influenza influenza NN cord-317619-o7qfugjw 40 7 A a NN cord-317619-o7qfugjw 40 8 ( ( -LRB- cord-317619-o7qfugjw 40 9 H1N1 H1N1 NNP cord-317619-o7qfugjw 40 10 ) ) -RRB- cord-317619-o7qfugjw 40 11 virus virus NN cord-317619-o7qfugjw 40 12 pandemic pandemic NN cord-317619-o7qfugjw 40 13 of of IN cord-317619-o7qfugjw 40 14 2009 2009 CD cord-317619-o7qfugjw 40 15 , , , cord-317619-o7qfugjw 40 16 influenza influenza NN cord-317619-o7qfugjw 40 17 - - HYPH cord-317619-o7qfugjw 40 18 related relate VBN cord-317619-o7qfugjw 40 19 respiratory respiratory JJ cord-317619-o7qfugjw 40 20 failure failure NN cord-317619-o7qfugjw 40 21 has have VBZ cord-317619-o7qfugjw 40 22 become become VBN cord-317619-o7qfugjw 40 23 a a DT cord-317619-o7qfugjw 40 24 notable notable JJ cord-317619-o7qfugjw 40 25 cause cause NN cord-317619-o7qfugjw 40 26 of of IN cord-317619-o7qfugjw 40 27 ARDS ARDS NNP cord-317619-o7qfugjw 40 28 ( ( -LRB- cord-317619-o7qfugjw 40 29 17 17 CD cord-317619-o7qfugjw 40 30 ) ) -RRB- cord-317619-o7qfugjw 40 31 . . . cord-317619-o7qfugjw 41 1 During during IN cord-317619-o7qfugjw 41 2 the the DT cord-317619-o7qfugjw 41 3 pandemic pandemic NN cord-317619-o7qfugjw 41 4 and and CC cord-317619-o7qfugjw 41 5 postpandemic postpandemic NNP cord-317619-o7qfugjw 41 6 era era NN cord-317619-o7qfugjw 41 7 , , , cord-317619-o7qfugjw 41 8 it -PRON- PRP cord-317619-o7qfugjw 41 9 is be VBZ cord-317619-o7qfugjw 41 10 clear clear JJ cord-317619-o7qfugjw 41 11 that that IN cord-317619-o7qfugjw 41 12 children child NNS cord-317619-o7qfugjw 41 13 are be VBP cord-317619-o7qfugjw 41 14 particularly particularly RB cord-317619-o7qfugjw 41 15 vulnerable vulnerable JJ cord-317619-o7qfugjw 41 16 to to IN cord-317619-o7qfugjw 41 17 disease disease NN cord-317619-o7qfugjw 41 18 even even RB cord-317619-o7qfugjw 41 19 if if IN cord-317619-o7qfugjw 41 20 they -PRON- PRP cord-317619-o7qfugjw 41 21 had have VBD cord-317619-o7qfugjw 41 22 been be VBN cord-317619-o7qfugjw 41 23 previously previously RB cord-317619-o7qfugjw 41 24 healthy healthy JJ cord-317619-o7qfugjw 41 25 ( ( -LRB- cord-317619-o7qfugjw 41 26 18 18 CD cord-317619-o7qfugjw 41 27 ) ) -RRB- cord-317619-o7qfugjw 41 28 . . . cord-317619-o7qfugjw 42 1 In in IN cord-317619-o7qfugjw 42 2 2009 2009 CD cord-317619-o7qfugjw 42 3 alone alone RB cord-317619-o7qfugjw 42 4 , , , cord-317619-o7qfugjw 42 5 more more JJR cord-317619-o7qfugjw 42 6 than than IN cord-317619-o7qfugjw 42 7 43,000 43,000 CD cord-317619-o7qfugjw 42 8 cases case NNS cord-317619-o7qfugjw 42 9 were be VBD cord-317619-o7qfugjw 42 10 reported report VBN cord-317619-o7qfugjw 42 11 , , , cord-317619-o7qfugjw 42 12 with with IN cord-317619-o7qfugjw 42 13 an an DT cord-317619-o7qfugjw 42 14 estimated estimate VBN cord-317619-o7qfugjw 42 15 73 73 CD cord-317619-o7qfugjw 42 16 % % NN cord-317619-o7qfugjw 42 17 of of IN cord-317619-o7qfugjw 42 18 cases case NNS cord-317619-o7qfugjw 42 19 occurring occur VBG cord-317619-o7qfugjw 42 20 in in IN cord-317619-o7qfugjw 42 21 patients patient NNS cord-317619-o7qfugjw 42 22 less less JJR cord-317619-o7qfugjw 42 23 than than IN cord-317619-o7qfugjw 42 24 24 24 CD cord-317619-o7qfugjw 42 25 years year NNS cord-317619-o7qfugjw 42 26 of of IN cord-317619-o7qfugjw 42 27 age age NN cord-317619-o7qfugjw 42 28 ( ( -LRB- cord-317619-o7qfugjw 42 29 13 13 CD cord-317619-o7qfugjw 42 30 ) ) -RRB- cord-317619-o7qfugjw 42 31 . . . cord-317619-o7qfugjw 43 1 In in IN cord-317619-o7qfugjw 43 2 previous previous JJ cord-317619-o7qfugjw 43 3 years year NNS cord-317619-o7qfugjw 43 4 , , , cord-317619-o7qfugjw 43 5 influenza influenza NN cord-317619-o7qfugjw 43 6 - - HYPH cord-317619-o7qfugjw 43 7 related relate VBN cord-317619-o7qfugjw 43 8 pediatric pediatric JJ cord-317619-o7qfugjw 43 9 deaths death NNS cord-317619-o7qfugjw 43 10 averaged average VBD cord-317619-o7qfugjw 43 11 82 82 CD cord-317619-o7qfugjw 43 12 annually annually RB cord-317619-o7qfugjw 43 13 but but CC cord-317619-o7qfugjw 43 14 increased increase VBD cord-317619-o7qfugjw 43 15 to to IN cord-317619-o7qfugjw 43 16 317 317 CD cord-317619-o7qfugjw 43 17 during during IN cord-317619-o7qfugjw 43 18 the the DT cord-317619-o7qfugjw 43 19 2009 2009 CD cord-317619-o7qfugjw 43 20 pandemic pandemic NN cord-317619-o7qfugjw 43 21 ( ( -LRB- cord-317619-o7qfugjw 43 22 19 19 CD cord-317619-o7qfugjw 43 23 ) ) -RRB- cord-317619-o7qfugjw 43 24 . . . cord-317619-o7qfugjw 44 1 While while IN cord-317619-o7qfugjw 44 2 post post JJ cord-317619-o7qfugjw 44 3 - - JJ cord-317619-o7qfugjw 44 4 pandemic pandemic JJ cord-317619-o7qfugjw 44 5 studies study NNS cord-317619-o7qfugjw 44 6 suggest suggest VBP cord-317619-o7qfugjw 44 7 a a DT cord-317619-o7qfugjw 44 8 decrease decrease NN cord-317619-o7qfugjw 44 9 in in IN cord-317619-o7qfugjw 44 10 influenza influenza NN cord-317619-o7qfugjw 44 11 A a NN cord-317619-o7qfugjw 44 12 ( ( -LRB- cord-317619-o7qfugjw 44 13 H1N1 H1N1 NNP cord-317619-o7qfugjw 44 14 ) ) -RRB- cord-317619-o7qfugjw 44 15 virus virus NN cord-317619-o7qfugjw 44 16 disease disease NN cord-317619-o7qfugjw 44 17 severity severity NN cord-317619-o7qfugjw 44 18 and and CC cord-317619-o7qfugjw 44 19 burden burden NN cord-317619-o7qfugjw 44 20 ( ( -LRB- cord-317619-o7qfugjw 44 21 20 20 CD cord-317619-o7qfugjw 44 22 , , , cord-317619-o7qfugjw 44 23 21 21 CD cord-317619-o7qfugjw 44 24 ) ) -RRB- cord-317619-o7qfugjw 44 25 , , , cord-317619-o7qfugjw 44 26 it -PRON- PRP cord-317619-o7qfugjw 44 27 continues continue VBZ cord-317619-o7qfugjw 44 28 to to TO cord-317619-o7qfugjw 44 29 be be VB cord-317619-o7qfugjw 44 30 a a DT cord-317619-o7qfugjw 44 31 significant significant JJ cord-317619-o7qfugjw 44 32 cause cause NN cord-317619-o7qfugjw 44 33 of of IN cord-317619-o7qfugjw 44 34 severe severe JJ cord-317619-o7qfugjw 44 35 illness illness NN cord-317619-o7qfugjw 44 36 and and CC cord-317619-o7qfugjw 44 37 pediatric pediatric JJ cord-317619-o7qfugjw 44 38 ARDS ARDS NNP cord-317619-o7qfugjw 44 39 ( ( -LRB- cord-317619-o7qfugjw 44 40 22 22 CD cord-317619-o7qfugjw 44 41 ) ) -RRB- cord-317619-o7qfugjw 44 42 . . . cord-317619-o7qfugjw 45 1 In in IN cord-317619-o7qfugjw 45 2 a a DT cord-317619-o7qfugjw 45 3 retrospective retrospective JJ cord-317619-o7qfugjw 45 4 analysis analysis NN cord-317619-o7qfugjw 45 5 of of IN cord-317619-o7qfugjw 45 6 adult adult NN cord-317619-o7qfugjw 45 7 patients patient NNS cord-317619-o7qfugjw 45 8 within within IN cord-317619-o7qfugjw 45 9 the the DT cord-317619-o7qfugjw 45 10 German german JJ cord-317619-o7qfugjw 45 11 ARDS ARDS NNP cord-317619-o7qfugjw 45 12 network network NN cord-317619-o7qfugjw 45 13 , , , cord-317619-o7qfugjw 45 14 investigators investigator NNS cord-317619-o7qfugjw 45 15 reported report VBD cord-317619-o7qfugjw 45 16 that that IN cord-317619-o7qfugjw 45 17 32 32 CD cord-317619-o7qfugjw 45 18 % % NN cord-317619-o7qfugjw 45 19 of of IN cord-317619-o7qfugjw 45 20 ARDS ARDS NNP cord-317619-o7qfugjw 45 21 patients patient NNS cord-317619-o7qfugjw 45 22 were be VBD cord-317619-o7qfugjw 45 23 influenza influenza VBG cord-317619-o7qfugjw 45 24 A a NN cord-317619-o7qfugjw 45 25 ( ( -LRB- cord-317619-o7qfugjw 45 26 H1N1 H1N1 NNP cord-317619-o7qfugjw 45 27 ) ) -RRB- cord-317619-o7qfugjw 45 28 virus virus NN cord-317619-o7qfugjw 45 29 positive positive JJ cord-317619-o7qfugjw 45 30 ( ( -LRB- cord-317619-o7qfugjw 45 31 23 23 CD cord-317619-o7qfugjw 45 32 ) ) -RRB- cord-317619-o7qfugjw 45 33 . . . cord-317619-o7qfugjw 46 1 In in IN cord-317619-o7qfugjw 46 2 another another DT cord-317619-o7qfugjw 46 3 pediatric pediatric JJ cord-317619-o7qfugjw 46 4 study study NN cord-317619-o7qfugjw 46 5 in in IN cord-317619-o7qfugjw 46 6 India India NNP cord-317619-o7qfugjw 46 7 , , , cord-317619-o7qfugjw 46 8 Kinikar Kinikar NNP cord-317619-o7qfugjw 46 9 et et NNP cord-317619-o7qfugjw 46 10 al al NNP cord-317619-o7qfugjw 46 11 . . NNP cord-317619-o7qfugjw 46 12 reported report VBD cord-317619-o7qfugjw 46 13 that that IN cord-317619-o7qfugjw 46 14 18 18 CD cord-317619-o7qfugjw 46 15 % % NN cord-317619-o7qfugjw 46 16 of of IN cord-317619-o7qfugjw 46 17 patients patient NNS cord-317619-o7qfugjw 46 18 hospitalized hospitalize VBN cord-317619-o7qfugjw 46 19 with with IN cord-317619-o7qfugjw 46 20 confirmed confirm VBN cord-317619-o7qfugjw 46 21 influenza influenza NN cord-317619-o7qfugjw 46 22 A a NN cord-317619-o7qfugjw 46 23 ( ( -LRB- cord-317619-o7qfugjw 46 24 H1N1 H1N1 NNP cord-317619-o7qfugjw 46 25 ) ) -RRB- cord-317619-o7qfugjw 46 26 virus virus NN cord-317619-o7qfugjw 46 27 developed develop VBD cord-317619-o7qfugjw 46 28 ARDS ARDS NNP cord-317619-o7qfugjw 46 29 ( ( -LRB- cord-317619-o7qfugjw 46 30 24 24 CD cord-317619-o7qfugjw 46 31 ) ) -RRB- cord-317619-o7qfugjw 46 32 . . . cord-317619-o7qfugjw 47 1 In in IN cord-317619-o7qfugjw 47 2 this this DT cord-317619-o7qfugjw 47 3 study study NN cord-317619-o7qfugjw 47 4 , , , cord-317619-o7qfugjw 47 5 9 9 CD cord-317619-o7qfugjw 47 6 of of IN cord-317619-o7qfugjw 47 7 the the DT cord-317619-o7qfugjw 47 8 15 15 CD cord-317619-o7qfugjw 47 9 children child NNS cord-317619-o7qfugjw 47 10 who who WP cord-317619-o7qfugjw 47 11 died die VBD cord-317619-o7qfugjw 47 12 were be VBD cord-317619-o7qfugjw 47 13 found find VBN cord-317619-o7qfugjw 47 14 to to TO cord-317619-o7qfugjw 47 15 have have VB cord-317619-o7qfugjw 47 16 histologic histologic JJ cord-317619-o7qfugjw 47 17 pulmonary pulmonary JJ cord-317619-o7qfugjw 47 18 findings finding NNS cord-317619-o7qfugjw 47 19 reflective reflective JJ cord-317619-o7qfugjw 47 20 of of IN cord-317619-o7qfugjw 47 21 ARDS ARDS NNP cord-317619-o7qfugjw 47 22 at at IN cord-317619-o7qfugjw 47 23 autopsy autopsy NN cord-317619-o7qfugjw 47 24 . . . cord-317619-o7qfugjw 48 1 In in IN cord-317619-o7qfugjw 48 2 Argentina Argentina NNP cord-317619-o7qfugjw 48 3 , , , cord-317619-o7qfugjw 48 4 Farias Farias NNP cord-317619-o7qfugjw 48 5 et et NNP cord-317619-o7qfugjw 48 6 al al NNP cord-317619-o7qfugjw 48 7 . . . cord-317619-o7qfugjw 48 8 studied study VBD cord-317619-o7qfugjw 48 9 147 147 CD cord-317619-o7qfugjw 48 10 patients patient NNS cord-317619-o7qfugjw 48 11 admitted admit VBN cord-317619-o7qfugjw 48 12 with with IN cord-317619-o7qfugjw 48 13 respiratory respiratory JJ cord-317619-o7qfugjw 48 14 failure failure NN cord-317619-o7qfugjw 48 15 due due IN cord-317619-o7qfugjw 48 16 to to IN cord-317619-o7qfugjw 48 17 influenza influenza NN cord-317619-o7qfugjw 48 18 A a NN cord-317619-o7qfugjw 48 19 ( ( -LRB- cord-317619-o7qfugjw 48 20 H1N1 H1N1 NNP cord-317619-o7qfugjw 48 21 ) ) -RRB- cord-317619-o7qfugjw 48 22 virus virus NN cord-317619-o7qfugjw 48 23 and and CC cord-317619-o7qfugjw 48 24 found find VBD cord-317619-o7qfugjw 48 25 118 118 CD cord-317619-o7qfugjw 48 26 ( ( -LRB- cord-317619-o7qfugjw 48 27 80 80 CD cord-317619-o7qfugjw 48 28 % % NN cord-317619-o7qfugjw 48 29 ) ) -RRB- cord-317619-o7qfugjw 48 30 met meet VBD cord-317619-o7qfugjw 48 31 criteria criterion NNS cord-317619-o7qfugjw 48 32 for for IN cord-317619-o7qfugjw 48 33 pediatric pediatric JJ cord-317619-o7qfugjw 48 34 ARDS ARDS NNP cord-317619-o7qfugjw 48 35 , , , cord-317619-o7qfugjw 48 36 45 45 CD cord-317619-o7qfugjw 48 37 % % NN cord-317619-o7qfugjw 48 38 of of IN cord-317619-o7qfugjw 48 39 whom whom WP cord-317619-o7qfugjw 48 40 died die VBD cord-317619-o7qfugjw 48 41 within within IN cord-317619-o7qfugjw 48 42 28 28 CD cord-317619-o7qfugjw 48 43 days day NNS cord-317619-o7qfugjw 48 44 after after IN cord-317619-o7qfugjw 48 45 PICU PICU NNP cord-317619-o7qfugjw 48 46 admission admission NN cord-317619-o7qfugjw 48 47 ( ( -LRB- cord-317619-o7qfugjw 48 48 25 25 CD cord-317619-o7qfugjw 48 49 ) ) -RRB- cord-317619-o7qfugjw 48 50 . . . cord-317619-o7qfugjw 49 1 The the DT cord-317619-o7qfugjw 49 2 second second JJ cord-317619-o7qfugjw 49 3 , , , cord-317619-o7qfugjw 49 4 less less RBR cord-317619-o7qfugjw 49 5 common common JJ cord-317619-o7qfugjw 49 6 novel novel NN cord-317619-o7qfugjw 49 7 influenza influenza NN cord-317619-o7qfugjw 49 8 virus virus NN cord-317619-o7qfugjw 49 9 , , , cord-317619-o7qfugjw 49 10 avian avian JJ cord-317619-o7qfugjw 49 11 influenza influenza NN cord-317619-o7qfugjw 49 12 A a NN cord-317619-o7qfugjw 49 13 ( ( -LRB- cord-317619-o7qfugjw 49 14 H5N1 H5N1 NNP cord-317619-o7qfugjw 49 15 ) ) -RRB- cord-317619-o7qfugjw 49 16 virus virus NN cord-317619-o7qfugjw 49 17 , , , cord-317619-o7qfugjw 49 18 was be VBD cord-317619-o7qfugjw 49 19 first first RB cord-317619-o7qfugjw 49 20 identified identify VBN cord-317619-o7qfugjw 49 21 in in IN cord-317619-o7qfugjw 49 22 1998 1998 CD cord-317619-o7qfugjw 49 23 ( ( -LRB- cord-317619-o7qfugjw 49 24 26 26 CD cord-317619-o7qfugjw 49 25 ) ) -RRB- cord-317619-o7qfugjw 49 26 and and CC cord-317619-o7qfugjw 49 27 remains remain VBZ cord-317619-o7qfugjw 49 28 a a DT cord-317619-o7qfugjw 49 29 common common JJ cord-317619-o7qfugjw 49 30 cause cause NN cord-317619-o7qfugjw 49 31 of of IN cord-317619-o7qfugjw 49 32 severe severe JJ cord-317619-o7qfugjw 49 33 respiratory respiratory JJ cord-317619-o7qfugjw 49 34 disease disease NN cord-317619-o7qfugjw 49 35 ( ( -LRB- cord-317619-o7qfugjw 49 36 27 27 CD cord-317619-o7qfugjw 49 37 ) ) -RRB- cord-317619-o7qfugjw 49 38 . . . cord-317619-o7qfugjw 50 1 Kawachi Kawachi NNP cord-317619-o7qfugjw 50 2 et et NNP cord-317619-o7qfugjw 50 3 al al NNP cord-317619-o7qfugjw 50 4 . . . cord-317619-o7qfugjw 51 1 reviewed review VBD cord-317619-o7qfugjw 51 2 pediatric pediatric JJ cord-317619-o7qfugjw 51 3 patients patient NNS cord-317619-o7qfugjw 51 4 with with IN cord-317619-o7qfugjw 51 5 ARDS ARDS NNP cord-317619-o7qfugjw 51 6 over over IN cord-317619-o7qfugjw 51 7 a a DT cord-317619-o7qfugjw 51 8 4½-year 4½-year CD cord-317619-o7qfugjw 51 9 period period NN cord-317619-o7qfugjw 51 10 in in IN cord-317619-o7qfugjw 51 11 Vietnam Vietnam NNP cord-317619-o7qfugjw 51 12 and and CC cord-317619-o7qfugjw 51 13 found find VBD cord-317619-o7qfugjw 51 14 12 12 CD cord-317619-o7qfugjw 51 15 ( ( -LRB- cord-317619-o7qfugjw 51 16 32.4 32.4 CD cord-317619-o7qfugjw 51 17 % % NN cord-317619-o7qfugjw 51 18 ) ) -RRB- cord-317619-o7qfugjw 51 19 of of IN cord-317619-o7qfugjw 51 20 the the DT cord-317619-o7qfugjw 51 21 37 37 CD cord-317619-o7qfugjw 51 22 patients patient NNS cord-317619-o7qfugjw 51 23 to to TO cord-317619-o7qfugjw 51 24 have have VB cord-317619-o7qfugjw 51 25 confirmed confirm VBN cord-317619-o7qfugjw 51 26 infection infection NN cord-317619-o7qfugjw 51 27 with with IN cord-317619-o7qfugjw 51 28 the the DT cord-317619-o7qfugjw 51 29 highly highly RB cord-317619-o7qfugjw 51 30 pathogenic pathogenic JJ cord-317619-o7qfugjw 51 31 influenza influenza NN cord-317619-o7qfugjw 51 32 A a NN cord-317619-o7qfugjw 51 33 ( ( -LRB- cord-317619-o7qfugjw 51 34 H5N1 H5N1 NNP cord-317619-o7qfugjw 51 35 ) ) -RRB- cord-317619-o7qfugjw 51 36 virus virus NN cord-317619-o7qfugjw 51 37 ( ( -LRB- cord-317619-o7qfugjw 51 38 28 28 CD cord-317619-o7qfugjw 51 39 ) ) -RRB- cord-317619-o7qfugjw 51 40 . . . cord-317619-o7qfugjw 52 1 They -PRON- PRP cord-317619-o7qfugjw 52 2 described describe VBD cord-317619-o7qfugjw 52 3 rapid rapid JJ cord-317619-o7qfugjw 52 4 progression progression NN cord-317619-o7qfugjw 52 5 of of IN cord-317619-o7qfugjw 52 6 disease disease NN cord-317619-o7qfugjw 52 7 to to IN cord-317619-o7qfugjw 52 8 ARDS ARDS NNP cord-317619-o7qfugjw 52 9 with with IN cord-317619-o7qfugjw 52 10 nine nine CD cord-317619-o7qfugjw 52 11 ( ( -LRB- cord-317619-o7qfugjw 52 12 75 75 CD cord-317619-o7qfugjw 52 13 % % NN cord-317619-o7qfugjw 52 14 ) ) -RRB- cord-317619-o7qfugjw 52 15 resulting result VBG cord-317619-o7qfugjw 52 16 in in IN cord-317619-o7qfugjw 52 17 death death NN cord-317619-o7qfugjw 52 18 . . . cord-317619-o7qfugjw 53 1 Further further JJ cord-317619-o7qfugjw 53 2 investigation investigation NN cord-317619-o7qfugjw 53 3 has have VBZ cord-317619-o7qfugjw 53 4 led lead VBN cord-317619-o7qfugjw 53 5 to to IN cord-317619-o7qfugjw 53 6 improved improve VBN cord-317619-o7qfugjw 53 7 understanding understanding NN cord-317619-o7qfugjw 53 8 of of IN cord-317619-o7qfugjw 53 9 transmission transmission NN cord-317619-o7qfugjw 53 10 , , , cord-317619-o7qfugjw 53 11 predominantly predominantly RB cord-317619-o7qfugjw 53 12 direct direct JJ cord-317619-o7qfugjw 53 13 avian avian JJ cord-317619-o7qfugjw 53 14 - - HYPH cord-317619-o7qfugjw 53 15 to to IN cord-317619-o7qfugjw 53 16 - - HYPH cord-317619-o7qfugjw 53 17 human human JJ cord-317619-o7qfugjw 53 18 transmission transmission NN cord-317619-o7qfugjw 53 19 with with IN cord-317619-o7qfugjw 53 20 significant significant JJ cord-317619-o7qfugjw 53 21 risk risk NN cord-317619-o7qfugjw 53 22 in in IN cord-317619-o7qfugjw 53 23 handling handle VBG cord-317619-o7qfugjw 53 24 sick sick JJ cord-317619-o7qfugjw 53 25 or or CC cord-317619-o7qfugjw 53 26 dead dead JJ cord-317619-o7qfugjw 53 27 poultry poultry NN cord-317619-o7qfugjw 53 28 . . . cord-317619-o7qfugjw 54 1 Type type NN cord-317619-o7qfugjw 54 2 2 2 CD cord-317619-o7qfugjw 54 3 pneumocytes pneumocyte NNS cord-317619-o7qfugjw 54 4 and and CC cord-317619-o7qfugjw 54 5 macrophages macrophage NNS cord-317619-o7qfugjw 54 6 are be VBP cord-317619-o7qfugjw 54 7 the the DT cord-317619-o7qfugjw 54 8 primary primary JJ cord-317619-o7qfugjw 54 9 lung lung NN cord-317619-o7qfugjw 54 10 target target NN cord-317619-o7qfugjw 54 11 ( ( -LRB- cord-317619-o7qfugjw 54 12 29 29 CD cord-317619-o7qfugjw 54 13 ) ) -RRB- cord-317619-o7qfugjw 54 14 . . . cord-317619-o7qfugjw 55 1 Together together RB cord-317619-o7qfugjw 55 2 , , , cord-317619-o7qfugjw 55 3 these these DT cord-317619-o7qfugjw 55 4 studies study NNS cord-317619-o7qfugjw 55 5 demonstrate demonstrate VBP cord-317619-o7qfugjw 55 6 that that IN cord-317619-o7qfugjw 55 7 RSV RSV NNP cord-317619-o7qfugjw 55 8 and and CC cord-317619-o7qfugjw 55 9 influenza influenza NN cord-317619-o7qfugjw 55 10 virus virus NN cord-317619-o7qfugjw 55 11 infection infection NN cord-317619-o7qfugjw 55 12 play play VBP cord-317619-o7qfugjw 55 13 a a DT cord-317619-o7qfugjw 55 14 role role NN cord-317619-o7qfugjw 55 15 in in IN cord-317619-o7qfugjw 55 16 the the DT cord-317619-o7qfugjw 55 17 development development NN cord-317619-o7qfugjw 55 18 of of IN cord-317619-o7qfugjw 55 19 pediatric pediatric JJ cord-317619-o7qfugjw 55 20 ARDS ARDS NNP cord-317619-o7qfugjw 55 21 . . . cord-317619-o7qfugjw 56 1 However however RB cord-317619-o7qfugjw 56 2 , , , cord-317619-o7qfugjw 56 3 to to TO cord-317619-o7qfugjw 56 4 better better RB cord-317619-o7qfugjw 56 5 understand understand VB cord-317619-o7qfugjw 56 6 the the DT cord-317619-o7qfugjw 56 7 disease disease NN cord-317619-o7qfugjw 56 8 burden burden NN cord-317619-o7qfugjw 56 9 , , , cord-317619-o7qfugjw 56 10 future future JJ cord-317619-o7qfugjw 56 11 studies study NNS cord-317619-o7qfugjw 56 12 should should MD cord-317619-o7qfugjw 56 13 seek seek VB cord-317619-o7qfugjw 56 14 to to TO cord-317619-o7qfugjw 56 15 more more RBR cord-317619-o7qfugjw 56 16 clearly clearly RB cord-317619-o7qfugjw 56 17 identify identify VB cord-317619-o7qfugjw 56 18 the the DT cord-317619-o7qfugjw 56 19 rate rate NN cord-317619-o7qfugjw 56 20 of of IN cord-317619-o7qfugjw 56 21 occurrence occurrence NN cord-317619-o7qfugjw 56 22 of of IN cord-317619-o7qfugjw 56 23 primary primary JJ cord-317619-o7qfugjw 56 24 viral viral JJ cord-317619-o7qfugjw 56 25 - - HYPH cord-317619-o7qfugjw 56 26 induced induce VBN cord-317619-o7qfugjw 56 27 ARDS ARDS NNP cord-317619-o7qfugjw 56 28 , , , cord-317619-o7qfugjw 56 29 as as RB cord-317619-o7qfugjw 56 30 well well RB cord-317619-o7qfugjw 56 31 as as IN cord-317619-o7qfugjw 56 32 incidence incidence NN cord-317619-o7qfugjw 56 33 of of IN cord-317619-o7qfugjw 56 34 secondary secondary JJ cord-317619-o7qfugjw 56 35 viral viral RB cord-317619-o7qfugjw 56 36 - - HYPH cord-317619-o7qfugjw 56 37 induced induce VBN cord-317619-o7qfugjw 56 38 lung lung NN cord-317619-o7qfugjw 56 39 injury injury NN cord-317619-o7qfugjw 56 40 . . . cord-317619-o7qfugjw 57 1 Furthermore furthermore RB cord-317619-o7qfugjw 57 2 , , , cord-317619-o7qfugjw 57 3 in in IN cord-317619-o7qfugjw 57 4 patients patient NNS cord-317619-o7qfugjw 57 5 who who WP cord-317619-o7qfugjw 57 6 have have VBP cord-317619-o7qfugjw 57 7 a a DT cord-317619-o7qfugjw 57 8 coinfection coinfection NN cord-317619-o7qfugjw 57 9 with with IN cord-317619-o7qfugjw 57 10 a a DT cord-317619-o7qfugjw 57 11 bacterial bacterial JJ cord-317619-o7qfugjw 57 12 pathogen pathogen NN cord-317619-o7qfugjw 57 13 , , , cord-317619-o7qfugjw 57 14 it -PRON- PRP cord-317619-o7qfugjw 57 15 may may MD cord-317619-o7qfugjw 57 16 be be VB cord-317619-o7qfugjw 57 17 hard hard JJ cord-317619-o7qfugjw 57 18 to to TO cord-317619-o7qfugjw 57 19 determine determine VB cord-317619-o7qfugjw 57 20 whether whether IN cord-317619-o7qfugjw 57 21 the the DT cord-317619-o7qfugjw 57 22 virus virus NN cord-317619-o7qfugjw 57 23 or or CC cord-317619-o7qfugjw 57 24 bacteria bacteria NNS cord-317619-o7qfugjw 57 25 played play VBD cord-317619-o7qfugjw 57 26 the the DT cord-317619-o7qfugjw 57 27 inciting incite VBG cord-317619-o7qfugjw 57 28 role role NN cord-317619-o7qfugjw 57 29 in in IN cord-317619-o7qfugjw 57 30 the the DT cord-317619-o7qfugjw 57 31 development development NN cord-317619-o7qfugjw 57 32 and and CC cord-317619-o7qfugjw 57 33 progression progression NN cord-317619-o7qfugjw 57 34 of of IN cord-317619-o7qfugjw 57 35 pediatric pediatric JJ cord-317619-o7qfugjw 57 36 ARDS ARDS NNP cord-317619-o7qfugjw 57 37 . . . cord-317619-o7qfugjw 58 1 Taken take VBN cord-317619-o7qfugjw 58 2 together together RB cord-317619-o7qfugjw 58 3 , , , cord-317619-o7qfugjw 58 4 the the DT cord-317619-o7qfugjw 58 5 overall overall JJ cord-317619-o7qfugjw 58 6 mortality mortality NN cord-317619-o7qfugjw 58 7 attributable attributable JJ cord-317619-o7qfugjw 58 8 to to IN cord-317619-o7qfugjw 58 9 either either CC cord-317619-o7qfugjw 58 10 RSV RSV NNP cord-317619-o7qfugjw 58 11 or or CC cord-317619-o7qfugjw 58 12 influenza influenza NN cord-317619-o7qfugjw 58 13 is be VBZ cord-317619-o7qfugjw 58 14 relatively relatively RB cord-317619-o7qfugjw 58 15 similar similar JJ cord-317619-o7qfugjw 58 16 ; ; : cord-317619-o7qfugjw 58 17 thus thus RB cord-317619-o7qfugjw 58 18 , , , cord-317619-o7qfugjw 58 19 it -PRON- PRP cord-317619-o7qfugjw 58 20 is be VBZ cord-317619-o7qfugjw 58 21 more more RBR cord-317619-o7qfugjw 58 22 likely likely RB cord-317619-o7qfugjw 58 23 the the DT cord-317619-o7qfugjw 58 24 syndrome syndrome NN cord-317619-o7qfugjw 58 25 of of IN cord-317619-o7qfugjw 58 26 ARDS ARDS NNP cord-317619-o7qfugjw 58 27 and and CC cord-317619-o7qfugjw 58 28 associated associated JJ cord-317619-o7qfugjw 58 29 pathology pathology NN cord-317619-o7qfugjw 58 30 that that WDT cord-317619-o7qfugjw 58 31 is be VBZ cord-317619-o7qfugjw 58 32 responsible responsible JJ cord-317619-o7qfugjw 58 33 for for IN cord-317619-o7qfugjw 58 34 outcome outcome NN cord-317619-o7qfugjw 58 35 . . . cord-317619-o7qfugjw 59 1 While while IN cord-317619-o7qfugjw 59 2 RSV RSV NNP cord-317619-o7qfugjw 59 3 and and CC cord-317619-o7qfugjw 59 4 influenza influenza NN cord-317619-o7qfugjw 59 5 A a NN cord-317619-o7qfugjw 59 6 ( ( -LRB- cord-317619-o7qfugjw 59 7 H1N1 H1N1 NNP cord-317619-o7qfugjw 59 8 ) ) -RRB- cord-317619-o7qfugjw 59 9 virus virus NN cord-317619-o7qfugjw 59 10 are be VBP cord-317619-o7qfugjw 59 11 the the DT cord-317619-o7qfugjw 59 12 most most RBS cord-317619-o7qfugjw 59 13 commonly commonly RB cord-317619-o7qfugjw 59 14 reported report VBN cord-317619-o7qfugjw 59 15 viruses virus NNS cord-317619-o7qfugjw 59 16 leading lead VBG cord-317619-o7qfugjw 59 17 to to IN cord-317619-o7qfugjw 59 18 pediatric pediatric JJ cord-317619-o7qfugjw 59 19 ARDS ARDS NNP cord-317619-o7qfugjw 59 20 , , , cord-317619-o7qfugjw 59 21 other other JJ cord-317619-o7qfugjw 59 22 viral viral JJ cord-317619-o7qfugjw 59 23 pathogens pathogen NNS cord-317619-o7qfugjw 59 24 are be VBP cord-317619-o7qfugjw 59 25 worth worth JJ cord-317619-o7qfugjw 59 26 mentioning mention VBG cord-317619-o7qfugjw 59 27 . . . cord-317619-o7qfugjw 60 1 Typically typically RB cord-317619-o7qfugjw 60 2 viral viral JJ cord-317619-o7qfugjw 60 3 infections infection NNS cord-317619-o7qfugjw 60 4 leading lead VBG cord-317619-o7qfugjw 60 5 to to IN cord-317619-o7qfugjw 60 6 respiratory respiratory JJ cord-317619-o7qfugjw 60 7 failure failure NN cord-317619-o7qfugjw 60 8 in in IN cord-317619-o7qfugjw 60 9 the the DT cord-317619-o7qfugjw 60 10 ICU ICU NNP cord-317619-o7qfugjw 60 11 are be VBP cord-317619-o7qfugjw 60 12 separated separate VBN cord-317619-o7qfugjw 60 13 as as IN cord-317619-o7qfugjw 60 14 community community NN cord-317619-o7qfugjw 60 15 acquired acquire VBD cord-317619-o7qfugjw 60 16 and and CC cord-317619-o7qfugjw 60 17 nosocomial nosocomial JJ cord-317619-o7qfugjw 60 18 ( ( -LRB- cord-317619-o7qfugjw 60 19 30 30 CD cord-317619-o7qfugjw 60 20 ) ) -RRB- cord-317619-o7qfugjw 60 21 . . . cord-317619-o7qfugjw 61 1 Community community NN cord-317619-o7qfugjw 61 2 acquired acquire VBD cord-317619-o7qfugjw 61 3 viral viral JJ cord-317619-o7qfugjw 61 4 infections infection NNS cord-317619-o7qfugjw 61 5 include include VBP cord-317619-o7qfugjw 61 6 both both DT cord-317619-o7qfugjw 61 7 seasonal seasonal JJ cord-317619-o7qfugjw 61 8 and and CC cord-317619-o7qfugjw 61 9 pandemic pandemic NN cord-317619-o7qfugjw 61 10 pathogens pathogen NNS cord-317619-o7qfugjw 61 11 ( ( -LRB- cord-317619-o7qfugjw 61 12 31 31 CD cord-317619-o7qfugjw 61 13 ) ) -RRB- cord-317619-o7qfugjw 61 14 . . . cord-317619-o7qfugjw 62 1 Seasonal seasonal JJ cord-317619-o7qfugjw 62 2 viruses virus NNS cord-317619-o7qfugjw 62 3 most most RBS cord-317619-o7qfugjw 62 4 commonly commonly RB cord-317619-o7qfugjw 62 5 include include VBP cord-317619-o7qfugjw 62 6 RSV RSV NNP cord-317619-o7qfugjw 62 7 , , , cord-317619-o7qfugjw 62 8 non non JJ cord-317619-o7qfugjw 62 9 - - JJ cord-317619-o7qfugjw 62 10 pandemic pandemic JJ cord-317619-o7qfugjw 62 11 influenza influenza NN cord-317619-o7qfugjw 62 12 , , , cord-317619-o7qfugjw 62 13 rhinoviruses rhinovirus NNS cord-317619-o7qfugjw 62 14 , , , cord-317619-o7qfugjw 62 15 parainfluenza parainfluenza NNP cord-317619-o7qfugjw 62 16 , , , cord-317619-o7qfugjw 62 17 adenovirus adenovirus NN cord-317619-o7qfugjw 62 18 , , , cord-317619-o7qfugjw 62 19 coronaviruses coronaviruse NNS cord-317619-o7qfugjw 62 20 , , , cord-317619-o7qfugjw 62 21 and and CC cord-317619-o7qfugjw 62 22 human human JJ cord-317619-o7qfugjw 62 23 metapneumovirus metapneumovirus NNP cord-317619-o7qfugjw 62 24 ( ( -LRB- cord-317619-o7qfugjw 62 25 hMPV hmpv NN cord-317619-o7qfugjw 62 26 ) ) -RRB- cord-317619-o7qfugjw 62 27 . . . cord-317619-o7qfugjw 63 1 Seasonal seasonal JJ cord-317619-o7qfugjw 63 2 viruses virus NNS cord-317619-o7qfugjw 63 3 remain remain VBP cord-317619-o7qfugjw 63 4 the the DT cord-317619-o7qfugjw 63 5 most most RBS cord-317619-o7qfugjw 63 6 frequent frequent JJ cord-317619-o7qfugjw 63 7 cause cause NN cord-317619-o7qfugjw 63 8 of of IN cord-317619-o7qfugjw 63 9 childhood childhood NN cord-317619-o7qfugjw 63 10 community community NN cord-317619-o7qfugjw 63 11 acquired acquire VBD cord-317619-o7qfugjw 63 12 pneumonia pneumonia NN cord-317619-o7qfugjw 63 13 ( ( -LRB- cord-317619-o7qfugjw 63 14 32 32 CD cord-317619-o7qfugjw 63 15 ) ) -RRB- cord-317619-o7qfugjw 63 16 . . . cord-317619-o7qfugjw 64 1 The the DT cord-317619-o7qfugjw 64 2 most most RBS cord-317619-o7qfugjw 64 3 common common JJ cord-317619-o7qfugjw 64 4 etiology etiology NN cord-317619-o7qfugjw 64 5 of of IN cord-317619-o7qfugjw 64 6 pediatric pediatric JJ cord-317619-o7qfugjw 64 7 ARDS ARDS NNP cord-317619-o7qfugjw 64 8 is be VBZ cord-317619-o7qfugjw 64 9 primary primary JJ cord-317619-o7qfugjw 64 10 pneumonia pneumonia NN cord-317619-o7qfugjw 64 11 , , , cord-317619-o7qfugjw 64 12 with with IN cord-317619-o7qfugjw 64 13 or or CC cord-317619-o7qfugjw 64 14 without without IN cord-317619-o7qfugjw 64 15 systemic systemic JJ cord-317619-o7qfugjw 64 16 infection infection NN cord-317619-o7qfugjw 64 17 ( ( -LRB- cord-317619-o7qfugjw 64 18 15 15 CD cord-317619-o7qfugjw 64 19 ) ) -RRB- cord-317619-o7qfugjw 64 20 . . . cord-317619-o7qfugjw 65 1 It -PRON- PRP cord-317619-o7qfugjw 65 2 can can MD cord-317619-o7qfugjw 65 3 then then RB cord-317619-o7qfugjw 65 4 be be VB cord-317619-o7qfugjw 65 5 assumed assume VBN cord-317619-o7qfugjw 65 6 that that IN cord-317619-o7qfugjw 65 7 viral viral JJ cord-317619-o7qfugjw 65 8 infections infection NNS cord-317619-o7qfugjw 65 9 may may MD cord-317619-o7qfugjw 65 10 play play VB cord-317619-o7qfugjw 65 11 an an DT cord-317619-o7qfugjw 65 12 important important JJ cord-317619-o7qfugjw 65 13 role role NN cord-317619-o7qfugjw 65 14 in in IN cord-317619-o7qfugjw 65 15 development development NN cord-317619-o7qfugjw 65 16 of of IN cord-317619-o7qfugjw 65 17 pediatric pediatric JJ cord-317619-o7qfugjw 65 18 ARDS ARDS NNP cord-317619-o7qfugjw 65 19 . . . cord-317619-o7qfugjw 66 1 However however RB cord-317619-o7qfugjw 66 2 , , , cord-317619-o7qfugjw 66 3 determining determine VBG cord-317619-o7qfugjw 66 4 an an DT cord-317619-o7qfugjw 66 5 accurate accurate JJ cord-317619-o7qfugjw 66 6 estimate estimate NN cord-317619-o7qfugjw 66 7 of of IN cord-317619-o7qfugjw 66 8 the the DT cord-317619-o7qfugjw 66 9 disease disease NN cord-317619-o7qfugjw 66 10 burden burden NN cord-317619-o7qfugjw 66 11 of of IN cord-317619-o7qfugjw 66 12 viral viral RB cord-317619-o7qfugjw 66 13 - - HYPH cord-317619-o7qfugjw 66 14 induced induce VBN cord-317619-o7qfugjw 66 15 pediatric pediatric JJ cord-317619-o7qfugjw 66 16 ARDS ARDS NNP cord-317619-o7qfugjw 66 17 will will MD cord-317619-o7qfugjw 66 18 be be VB cord-317619-o7qfugjw 66 19 difficult difficult JJ cord-317619-o7qfugjw 66 20 , , , cord-317619-o7qfugjw 66 21 as as IN cord-317619-o7qfugjw 66 22 many many JJ cord-317619-o7qfugjw 66 23 simple simple JJ cord-317619-o7qfugjw 66 24 viral viral JJ cord-317619-o7qfugjw 66 25 infections infection NNS cord-317619-o7qfugjw 66 26 can can MD cord-317619-o7qfugjw 66 27 progress progress VB cord-317619-o7qfugjw 66 28 to to IN cord-317619-o7qfugjw 66 29 coinfection coinfection NN cord-317619-o7qfugjw 66 30 with with IN cord-317619-o7qfugjw 66 31 the the DT cord-317619-o7qfugjw 66 32 second second JJ cord-317619-o7qfugjw 66 33 virus virus NN cord-317619-o7qfugjw 66 34 or or CC cord-317619-o7qfugjw 66 35 a a DT cord-317619-o7qfugjw 66 36 bacterial bacterial JJ cord-317619-o7qfugjw 66 37 pathogen pathogen NN cord-317619-o7qfugjw 66 38 . . . cord-317619-o7qfugjw 67 1 As as IN cord-317619-o7qfugjw 67 2 will will MD cord-317619-o7qfugjw 67 3 be be VB cord-317619-o7qfugjw 67 4 detailed detail VBN cord-317619-o7qfugjw 67 5 below below RB cord-317619-o7qfugjw 67 6 , , , cord-317619-o7qfugjw 67 7 with with IN cord-317619-o7qfugjw 67 8 the the DT cord-317619-o7qfugjw 67 9 development development NN cord-317619-o7qfugjw 67 10 of of IN cord-317619-o7qfugjw 67 11 multiplex multiplex JJ cord-317619-o7qfugjw 67 12 PCR PCR NNP cord-317619-o7qfugjw 67 13 diagnostic diagnostic JJ cord-317619-o7qfugjw 67 14 platforms platform NNS cord-317619-o7qfugjw 67 15 that that WDT cord-317619-o7qfugjw 67 16 identify identify VBP cord-317619-o7qfugjw 67 17 multiple multiple JJ cord-317619-o7qfugjw 67 18 viral viral JJ cord-317619-o7qfugjw 67 19 agents agent NNS cord-317619-o7qfugjw 67 20 , , , cord-317619-o7qfugjw 67 21 further further RB cord-317619-o7qfugjw 67 22 insight insight NN cord-317619-o7qfugjw 67 23 into into IN cord-317619-o7qfugjw 67 24 coinfections coinfection NNS cord-317619-o7qfugjw 67 25 will will MD cord-317619-o7qfugjw 67 26 develop develop VB cord-317619-o7qfugjw 67 27 . . . cord-317619-o7qfugjw 68 1 A a DT cord-317619-o7qfugjw 68 2 single single JJ cord-317619-o7qfugjw 68 3 - - HYPH cord-317619-o7qfugjw 68 4 center center NN cord-317619-o7qfugjw 68 5 adult adult NN cord-317619-o7qfugjw 68 6 study study NN cord-317619-o7qfugjw 68 7 reported report VBD cord-317619-o7qfugjw 68 8 seven seven CD cord-317619-o7qfugjw 68 9 patients patient NNS cord-317619-o7qfugjw 68 10 developing develop VBG cord-317619-o7qfugjw 68 11 ARDS ARDS NNP cord-317619-o7qfugjw 68 12 from from IN cord-317619-o7qfugjw 68 13 adenovirus adenovirus NN cord-317619-o7qfugjw 68 14 , , , cord-317619-o7qfugjw 68 15 four four CD cord-317619-o7qfugjw 68 16 of of IN cord-317619-o7qfugjw 68 17 whom whom WP cord-317619-o7qfugjw 68 18 died die VBD cord-317619-o7qfugjw 68 19 ( ( -LRB- cord-317619-o7qfugjw 68 20 33 33 CD cord-317619-o7qfugjw 68 21 ) ) -RRB- cord-317619-o7qfugjw 68 22 . . . cord-317619-o7qfugjw 69 1 Hung Hung NNP cord-317619-o7qfugjw 69 2 and and CC cord-317619-o7qfugjw 69 3 Lin Lin NNP cord-317619-o7qfugjw 69 4 described describe VBD cord-317619-o7qfugjw 69 5 a a DT cord-317619-o7qfugjw 69 6 case case NN cord-317619-o7qfugjw 69 7 of of IN cord-317619-o7qfugjw 69 8 a a DT cord-317619-o7qfugjw 69 9 9-month 9-month JJ cord-317619-o7qfugjw 69 10 - - HYPH cord-317619-o7qfugjw 69 11 old old JJ cord-317619-o7qfugjw 69 12 male male NN cord-317619-o7qfugjw 69 13 with with IN cord-317619-o7qfugjw 69 14 adenoviral adenoviral NNP cord-317619-o7qfugjw 69 15 ARDS ARDS NNP cord-317619-o7qfugjw 69 16 requiring require VBG cord-317619-o7qfugjw 69 17 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 69 18 membrane membrane NN cord-317619-o7qfugjw 69 19 oxygenation oxygenation NN cord-317619-o7qfugjw 69 20 ( ( -LRB- cord-317619-o7qfugjw 69 21 ECMO ECMO NNP cord-317619-o7qfugjw 69 22 ) ) -RRB- cord-317619-o7qfugjw 69 23 ( ( -LRB- cord-317619-o7qfugjw 69 24 34 34 CD cord-317619-o7qfugjw 69 25 cases case NNS cord-317619-o7qfugjw 69 26 of of IN cord-317619-o7qfugjw 69 27 severe severe JJ cord-317619-o7qfugjw 69 28 disease disease NN cord-317619-o7qfugjw 69 29 in in IN cord-317619-o7qfugjw 69 30 immunocompetent immunocompetent JJ cord-317619-o7qfugjw 69 31 patients patient NNS cord-317619-o7qfugjw 69 32 are be VBP cord-317619-o7qfugjw 69 33 becoming become VBG cord-317619-o7qfugjw 69 34 increasingly increasingly RB cord-317619-o7qfugjw 69 35 reported report VBN cord-317619-o7qfugjw 69 36 ( ( -LRB- cord-317619-o7qfugjw 69 37 38 38 CD cord-317619-o7qfugjw 69 38 ) ) -RRB- cord-317619-o7qfugjw 69 39 . . . cord-317619-o7qfugjw 70 1 At at IN cord-317619-o7qfugjw 70 2 an an DT cord-317619-o7qfugjw 70 3 international international JJ cord-317619-o7qfugjw 70 4 level level NN cord-317619-o7qfugjw 70 5 , , , cord-317619-o7qfugjw 70 6 community community NN cord-317619-o7qfugjw 70 7 acquired acquire VBD cord-317619-o7qfugjw 70 8 , , , cord-317619-o7qfugjw 70 9 novel novel JJ cord-317619-o7qfugjw 70 10 pathogens pathogen NNS cord-317619-o7qfugjw 70 11 have have VBP cord-317619-o7qfugjw 70 12 been be VBN cord-317619-o7qfugjw 70 13 recognized recognize VBN cord-317619-o7qfugjw 70 14 as as IN cord-317619-o7qfugjw 70 15 a a DT cord-317619-o7qfugjw 70 16 significant significant JJ cord-317619-o7qfugjw 70 17 cause cause NN cord-317619-o7qfugjw 70 18 of of IN cord-317619-o7qfugjw 70 19 ARDS ARDS NNP cord-317619-o7qfugjw 70 20 in in IN cord-317619-o7qfugjw 70 21 the the DT cord-317619-o7qfugjw 70 22 last last JJ cord-317619-o7qfugjw 70 23 15 15 CD cord-317619-o7qfugjw 70 24 - - SYM cord-317619-o7qfugjw 70 25 20 20 CD cord-317619-o7qfugjw 70 26 years year NNS cord-317619-o7qfugjw 70 27 ( ( -LRB- cord-317619-o7qfugjw 70 28 31 31 CD cord-317619-o7qfugjw 70 29 ) ) -RRB- cord-317619-o7qfugjw 70 30 . . . cord-317619-o7qfugjw 71 1 In in IN cord-317619-o7qfugjw 71 2 2015 2015 CD cord-317619-o7qfugjw 71 3 , , , cord-317619-o7qfugjw 71 4 the the DT cord-317619-o7qfugjw 71 5 World World NNP cord-317619-o7qfugjw 71 6 Health Health NNP cord-317619-o7qfugjw 71 7 Organization Organization NNP cord-317619-o7qfugjw 71 8 ( ( -LRB- cord-317619-o7qfugjw 71 9 WHO who WP cord-317619-o7qfugjw 71 10 ) ) -RRB- cord-317619-o7qfugjw 71 11 developed develop VBD cord-317619-o7qfugjw 71 12 a a DT cord-317619-o7qfugjw 71 13 panel panel NN cord-317619-o7qfugjw 71 14 of of IN cord-317619-o7qfugjw 71 15 experts expert NNS cord-317619-o7qfugjw 71 16 to to TO cord-317619-o7qfugjw 71 17 prioritize prioritize VB cord-317619-o7qfugjw 71 18 emerging emerge VBG cord-317619-o7qfugjw 71 19 pathogens pathogen NNS cord-317619-o7qfugjw 71 20 to to TO cord-317619-o7qfugjw 71 21 likely likely RB cord-317619-o7qfugjw 71 22 cause cause VB cord-317619-o7qfugjw 71 23 severe severe JJ cord-317619-o7qfugjw 71 24 outbreaks outbreak NNS cord-317619-o7qfugjw 71 25 in in IN cord-317619-o7qfugjw 71 26 the the DT cord-317619-o7qfugjw 71 27 near near JJ cord-317619-o7qfugjw 71 28 future future NN cord-317619-o7qfugjw 71 29 , , , cord-317619-o7qfugjw 71 30 and and CC cord-317619-o7qfugjw 71 31 for for IN cord-317619-o7qfugjw 71 32 which which WDT cord-317619-o7qfugjw 71 33 little little JJ cord-317619-o7qfugjw 71 34 or or CC cord-317619-o7qfugjw 71 35 no no DT cord-317619-o7qfugjw 71 36 preventative preventative JJ cord-317619-o7qfugjw 71 37 or or CC cord-317619-o7qfugjw 71 38 curative curative JJ cord-317619-o7qfugjw 71 39 treatments treatment NNS cord-317619-o7qfugjw 71 40 are be VBP cord-317619-o7qfugjw 71 41 available available JJ cord-317619-o7qfugjw 71 42 ( ( -LRB- cord-317619-o7qfugjw 71 43 39 39 CD cord-317619-o7qfugjw 71 44 ) ) -RRB- cord-317619-o7qfugjw 71 45 . . . cord-317619-o7qfugjw 72 1 The the DT cord-317619-o7qfugjw 72 2 list list NN cord-317619-o7qfugjw 72 3 includes include VBZ cord-317619-o7qfugjw 72 4 two two CD cord-317619-o7qfugjw 72 5 novel novel NN cord-317619-o7qfugjw 72 6 coronaviruses coronaviruse NNS cord-317619-o7qfugjw 72 7 , , , cord-317619-o7qfugjw 72 8 severe severe JJ cord-317619-o7qfugjw 72 9 acute acute JJ cord-317619-o7qfugjw 72 10 respiratory respiratory JJ cord-317619-o7qfugjw 72 11 syndrome syndrome NN cord-317619-o7qfugjw 72 12 ( ( -LRB- cord-317619-o7qfugjw 72 13 SARS)-CoV SARS)-CoV NNP cord-317619-o7qfugjw 72 14 and and CC cord-317619-o7qfugjw 72 15 MERS MERS NNP cord-317619-o7qfugjw 72 16 - - HYPH cord-317619-o7qfugjw 72 17 CoV CoV NNP cord-317619-o7qfugjw 72 18 , , , cord-317619-o7qfugjw 72 19 which which WDT cord-317619-o7qfugjw 72 20 are be VBP cord-317619-o7qfugjw 72 21 widely widely RB cord-317619-o7qfugjw 72 22 recognized recognize VBN cord-317619-o7qfugjw 72 23 as as IN cord-317619-o7qfugjw 72 24 noteworthy noteworthy JJ cord-317619-o7qfugjw 72 25 causes cause NNS cord-317619-o7qfugjw 72 26 of of IN cord-317619-o7qfugjw 72 27 ARDS ARDS NNP cord-317619-o7qfugjw 72 28 . . . cord-317619-o7qfugjw 73 1 In in IN cord-317619-o7qfugjw 73 2 2002 2002 CD cord-317619-o7qfugjw 73 3 , , , cord-317619-o7qfugjw 73 4 SARS SARS NNP cord-317619-o7qfugjw 73 5 - - HYPH cord-317619-o7qfugjw 73 6 CoV CoV NNP cord-317619-o7qfugjw 73 7 led lead VBD cord-317619-o7qfugjw 73 8 to to IN cord-317619-o7qfugjw 73 9 the the DT cord-317619-o7qfugjw 73 10 development development NN cord-317619-o7qfugjw 73 11 of of IN cord-317619-o7qfugjw 73 12 SARS SARS NNP cord-317619-o7qfugjw 73 13 in in IN cord-317619-o7qfugjw 73 14 China China NNP cord-317619-o7qfugjw 73 15 ( ( -LRB- cord-317619-o7qfugjw 73 16 40 40 CD cord-317619-o7qfugjw 73 17 ) ) -RRB- cord-317619-o7qfugjw 73 18 . . . cord-317619-o7qfugjw 74 1 Affecting affect VBG cord-317619-o7qfugjw 74 2 patients patient NNS cord-317619-o7qfugjw 74 3 of of IN cord-317619-o7qfugjw 74 4 all all DT cord-317619-o7qfugjw 74 5 ages age NNS cord-317619-o7qfugjw 74 6 , , , cord-317619-o7qfugjw 74 7 SARS SARS NNP cord-317619-o7qfugjw 74 8 led lead VBD cord-317619-o7qfugjw 74 9 to to IN cord-317619-o7qfugjw 74 10 significant significant JJ cord-317619-o7qfugjw 74 11 mortality mortality NN cord-317619-o7qfugjw 74 12 worldwide worldwide RB cord-317619-o7qfugjw 74 13 within within IN cord-317619-o7qfugjw 74 14 a a DT cord-317619-o7qfugjw 74 15 few few JJ cord-317619-o7qfugjw 74 16 months month NNS cord-317619-o7qfugjw 74 17 ( ( -LRB- cord-317619-o7qfugjw 74 18 41 41 CD cord-317619-o7qfugjw 74 19 ) ) -RRB- cord-317619-o7qfugjw 74 20 . . . cord-317619-o7qfugjw 75 1 A a DT cord-317619-o7qfugjw 75 2 large large JJ cord-317619-o7qfugjw 75 3 number number NN cord-317619-o7qfugjw 75 4 of of IN cord-317619-o7qfugjw 75 5 infected infected JJ cord-317619-o7qfugjw 75 6 patients patient NNS cord-317619-o7qfugjw 75 7 developed develop VBD cord-317619-o7qfugjw 75 8 severe severe JJ cord-317619-o7qfugjw 75 9 complications complication NNS cord-317619-o7qfugjw 75 10 , , , cord-317619-o7qfugjw 75 11 with with IN cord-317619-o7qfugjw 75 12 20 20 CD cord-317619-o7qfugjw 75 13 % % NN cord-317619-o7qfugjw 75 14 developing develop VBG cord-317619-o7qfugjw 75 15 ARDS ARDS NNP cord-317619-o7qfugjw 75 16 ( ( -LRB- cord-317619-o7qfugjw 75 17 42 42 CD cord-317619-o7qfugjw 75 18 ) ) -RRB- cord-317619-o7qfugjw 75 19 . . . cord-317619-o7qfugjw 76 1 However however RB cord-317619-o7qfugjw 76 2 , , , cord-317619-o7qfugjw 76 3 reported report VBD cord-317619-o7qfugjw 76 4 SARS SARS NNP cord-317619-o7qfugjw 76 5 cases case NNS cord-317619-o7qfugjw 76 6 have have VBP cord-317619-o7qfugjw 76 7 ceased cease VBN cord-317619-o7qfugjw 76 8 since since IN cord-317619-o7qfugjw 76 9 2004 2004 CD cord-317619-o7qfugjw 76 10 as as IN cord-317619-o7qfugjw 76 11 the the DT cord-317619-o7qfugjw 76 12 spread spread NN cord-317619-o7qfugjw 76 13 of of IN cord-317619-o7qfugjw 76 14 infection infection NN cord-317619-o7qfugjw 76 15 has have VBZ cord-317619-o7qfugjw 76 16 subsided subside VBN cord-317619-o7qfugjw 76 17 ( ( -LRB- cord-317619-o7qfugjw 76 18 43 43 CD cord-317619-o7qfugjw 76 19 ) ) -RRB- cord-317619-o7qfugjw 76 20 . . . cord-317619-o7qfugjw 77 1 More more RBR cord-317619-o7qfugjw 77 2 recently recently RB cord-317619-o7qfugjw 77 3 , , , cord-317619-o7qfugjw 77 4 the the DT cord-317619-o7qfugjw 77 5 second second JJ cord-317619-o7qfugjw 77 6 novel novel JJ cord-317619-o7qfugjw 77 7 coronavirus coronavirus NN cord-317619-o7qfugjw 77 8 , , , cord-317619-o7qfugjw 77 9 MERS MERS NNP cord-317619-o7qfugjw 77 10 - - HYPH cord-317619-o7qfugjw 77 11 CoV CoV NNP cord-317619-o7qfugjw 77 12 , , , cord-317619-o7qfugjw 77 13 led lead VBD cord-317619-o7qfugjw 77 14 to to IN cord-317619-o7qfugjw 77 15 the the DT cord-317619-o7qfugjw 77 16 Middle Middle NNP cord-317619-o7qfugjw 77 17 East East NNP cord-317619-o7qfugjw 77 18 respiratory respiratory JJ cord-317619-o7qfugjw 77 19 syndrome syndrome NN cord-317619-o7qfugjw 77 20 ( ( -LRB- cord-317619-o7qfugjw 77 21 44 44 CD cord-317619-o7qfugjw 77 22 ) ) -RRB- cord-317619-o7qfugjw 77 23 . . . cord-317619-o7qfugjw 78 1 Clinical clinical JJ cord-317619-o7qfugjw 78 2 symptoms symptom NNS cord-317619-o7qfugjw 78 3 range range VBP cord-317619-o7qfugjw 78 4 from from IN cord-317619-o7qfugjw 78 5 mild mild JJ cord-317619-o7qfugjw 78 6 upper upper JJ cord-317619-o7qfugjw 78 7 respiratory respiratory JJ cord-317619-o7qfugjw 78 8 symptoms symptom NNS cord-317619-o7qfugjw 78 9 to to IN cord-317619-o7qfugjw 78 10 severe severe JJ cord-317619-o7qfugjw 78 11 pneumonia pneumonia NN cord-317619-o7qfugjw 78 12 and and CC cord-317619-o7qfugjw 78 13 ARDS ARDS NNP cord-317619-o7qfugjw 78 14 , , , cord-317619-o7qfugjw 78 15 septic septic JJ cord-317619-o7qfugjw 78 16 shock shock NN cord-317619-o7qfugjw 78 17 , , , cord-317619-o7qfugjw 78 18 and and CC cord-317619-o7qfugjw 78 19 multi multi JJ cord-317619-o7qfugjw 78 20 - - JJ cord-317619-o7qfugjw 78 21 organ organ JJ cord-317619-o7qfugjw 78 22 failure failure NN cord-317619-o7qfugjw 78 23 ( ( -LRB- cord-317619-o7qfugjw 78 24 45 45 CD cord-317619-o7qfugjw 78 25 ) ) -RRB- cord-317619-o7qfugjw 78 26 and and CC cord-317619-o7qfugjw 78 27 carry carry VB cord-317619-o7qfugjw 78 28 an an DT cord-317619-o7qfugjw 78 29 estimated estimate VBN cord-317619-o7qfugjw 78 30 mortality mortality NN cord-317619-o7qfugjw 78 31 of of IN cord-317619-o7qfugjw 78 32 40 40 CD cord-317619-o7qfugjw 78 33 % % NN cord-317619-o7qfugjw 78 34 ( ( -LRB- cord-317619-o7qfugjw 78 35 46 46 CD cord-317619-o7qfugjw 78 36 ) ) -RRB- cord-317619-o7qfugjw 78 37 . . . cord-317619-o7qfugjw 79 1 This this DT cord-317619-o7qfugjw 79 2 virus virus NN cord-317619-o7qfugjw 79 3 continues continue VBZ cord-317619-o7qfugjw 79 4 to to TO cord-317619-o7qfugjw 79 5 be be VB cord-317619-o7qfugjw 79 6 a a DT cord-317619-o7qfugjw 79 7 substantial substantial JJ cord-317619-o7qfugjw 79 8 etiology etiology NN cord-317619-o7qfugjw 79 9 of of IN cord-317619-o7qfugjw 79 10 ARDS ARDS NNP cord-317619-o7qfugjw 79 11 with with IN cord-317619-o7qfugjw 79 12 high high JJ cord-317619-o7qfugjw 79 13 mortality mortality NN cord-317619-o7qfugjw 79 14 as as IN cord-317619-o7qfugjw 79 15 no no DT cord-317619-o7qfugjw 79 16 definitive definitive JJ cord-317619-o7qfugjw 79 17 prevention prevention NN cord-317619-o7qfugjw 79 18 or or CC cord-317619-o7qfugjw 79 19 treatment treatment NN cord-317619-o7qfugjw 79 20 other other JJ cord-317619-o7qfugjw 79 21 than than IN cord-317619-o7qfugjw 79 22 supportive supportive JJ cord-317619-o7qfugjw 79 23 care care NN cord-317619-o7qfugjw 79 24 has have VBZ cord-317619-o7qfugjw 79 25 been be VBN cord-317619-o7qfugjw 79 26 identified identify VBN cord-317619-o7qfugjw 79 27 ( ( -LRB- cord-317619-o7qfugjw 79 28 47 47 CD cord-317619-o7qfugjw 79 29 ) ) -RRB- cord-317619-o7qfugjw 79 30 . . . cord-317619-o7qfugjw 80 1 With with IN cord-317619-o7qfugjw 80 2 the the DT cord-317619-o7qfugjw 80 3 unpredictable unpredictable JJ cord-317619-o7qfugjw 80 4 nature nature NN cord-317619-o7qfugjw 80 5 of of IN cord-317619-o7qfugjw 80 6 epidemics epidemic NNS cord-317619-o7qfugjw 80 7 and and CC cord-317619-o7qfugjw 80 8 pandemics pandemic NNS cord-317619-o7qfugjw 80 9 , , , cord-317619-o7qfugjw 80 10 these these DT cord-317619-o7qfugjw 80 11 novel novel JJ cord-317619-o7qfugjw 80 12 viruses virus NNS cord-317619-o7qfugjw 80 13 illustrate illustrate VBP cord-317619-o7qfugjw 80 14 the the DT cord-317619-o7qfugjw 80 15 need need NN cord-317619-o7qfugjw 80 16 to to TO cord-317619-o7qfugjw 80 17 improve improve VB cord-317619-o7qfugjw 80 18 our -PRON- PRP$ cord-317619-o7qfugjw 80 19 understanding understanding NN cord-317619-o7qfugjw 80 20 of of IN cord-317619-o7qfugjw 80 21 viral viral JJ cord-317619-o7qfugjw 80 22 progression progression NN cord-317619-o7qfugjw 80 23 to to IN cord-317619-o7qfugjw 80 24 ARDS ARDS NNP cord-317619-o7qfugjw 80 25 in in IN cord-317619-o7qfugjw 80 26 order order NN cord-317619-o7qfugjw 80 27 to to TO cord-317619-o7qfugjw 80 28 advance advance VB cord-317619-o7qfugjw 80 29 management management NN cord-317619-o7qfugjw 80 30 and and CC cord-317619-o7qfugjw 80 31 reduce reduce VB cord-317619-o7qfugjw 80 32 mortality mortality NN cord-317619-o7qfugjw 80 33 . . . cord-317619-o7qfugjw 81 1 Aside aside RB cord-317619-o7qfugjw 81 2 from from IN cord-317619-o7qfugjw 81 3 community community NN cord-317619-o7qfugjw 81 4 acquired acquire VBD cord-317619-o7qfugjw 81 5 viral viral JJ cord-317619-o7qfugjw 81 6 infections infection NNS cord-317619-o7qfugjw 81 7 , , , cord-317619-o7qfugjw 81 8 nosocomial nosocomial JJ cord-317619-o7qfugjw 81 9 infections infection NNS cord-317619-o7qfugjw 81 10 are be VBP cord-317619-o7qfugjw 81 11 an an DT cord-317619-o7qfugjw 81 12 important important JJ cord-317619-o7qfugjw 81 13 cause cause NN cord-317619-o7qfugjw 81 14 of of IN cord-317619-o7qfugjw 81 15 respiratory respiratory JJ cord-317619-o7qfugjw 81 16 illness illness NN cord-317619-o7qfugjw 81 17 , , , cord-317619-o7qfugjw 81 18 and and CC cord-317619-o7qfugjw 81 19 can can MD cord-317619-o7qfugjw 81 20 lead lead VB cord-317619-o7qfugjw 81 21 to to IN cord-317619-o7qfugjw 81 22 ARDS ARDS NNP cord-317619-o7qfugjw 81 23 in in IN cord-317619-o7qfugjw 81 24 both both DT cord-317619-o7qfugjw 81 25 adults adult NNS cord-317619-o7qfugjw 81 26 and and CC cord-317619-o7qfugjw 81 27 children child NNS cord-317619-o7qfugjw 81 28 . . . cord-317619-o7qfugjw 82 1 In in IN cord-317619-o7qfugjw 82 2 mechanically mechanically RB cord-317619-o7qfugjw 82 3 ventilated ventilate VBN cord-317619-o7qfugjw 82 4 adults adult NNS cord-317619-o7qfugjw 82 5 , , , cord-317619-o7qfugjw 82 6 reactivation reactivation NN cord-317619-o7qfugjw 82 7 of of IN cord-317619-o7qfugjw 82 8 latent latent JJ cord-317619-o7qfugjw 82 9 herpes herpes NN cord-317619-o7qfugjw 82 10 simplex simplex NN cord-317619-o7qfugjw 82 11 virus virus NN cord-317619-o7qfugjw 82 12 ( ( -LRB- cord-317619-o7qfugjw 82 13 HSV HSV NNP cord-317619-o7qfugjw 82 14 ) ) -RRB- cord-317619-o7qfugjw 82 15 in in IN cord-317619-o7qfugjw 82 16 the the DT cord-317619-o7qfugjw 82 17 oropharynx oropharynx NN cord-317619-o7qfugjw 82 18 can can MD cord-317619-o7qfugjw 82 19 potentially potentially RB cord-317619-o7qfugjw 82 20 lead lead VB cord-317619-o7qfugjw 82 21 to to TO cord-317619-o7qfugjw 82 22 lower low JJR cord-317619-o7qfugjw 82 23 respiratory respiratory JJ cord-317619-o7qfugjw 82 24 tract tract NN cord-317619-o7qfugjw 82 25 infection infection NN cord-317619-o7qfugjw 82 26 and and CC cord-317619-o7qfugjw 82 27 ARDS ARDS NNP cord-317619-o7qfugjw 82 28 ( ( -LRB- cord-317619-o7qfugjw 82 29 48 48 CD cord-317619-o7qfugjw 82 30 , , , cord-317619-o7qfugjw 82 31 49 49 CD cord-317619-o7qfugjw 82 32 ) ) -RRB- cord-317619-o7qfugjw 82 33 . . . cord-317619-o7qfugjw 83 1 However however RB cord-317619-o7qfugjw 83 2 , , , cord-317619-o7qfugjw 83 3 the the DT cord-317619-o7qfugjw 83 4 pathogenicity pathogenicity NN cord-317619-o7qfugjw 83 5 of of IN cord-317619-o7qfugjw 83 6 reactivated reactivate VBN cord-317619-o7qfugjw 83 7 HSV HSV NNP cord-317619-o7qfugjw 83 8 lower low JJR cord-317619-o7qfugjw 83 9 respiratory respiratory JJ cord-317619-o7qfugjw 83 10 tract tract NN cord-317619-o7qfugjw 83 11 infection infection NN cord-317619-o7qfugjw 83 12 may may MD cord-317619-o7qfugjw 83 13 not not RB cord-317619-o7qfugjw 83 14 be be VB cord-317619-o7qfugjw 83 15 that that RB cord-317619-o7qfugjw 83 16 straightforward straightforward JJ cord-317619-o7qfugjw 83 17 as as IN cord-317619-o7qfugjw 83 18 it -PRON- PRP cord-317619-o7qfugjw 83 19 remains remain VBZ cord-317619-o7qfugjw 83 20 unclear unclear JJ cord-317619-o7qfugjw 83 21 whether whether IN cord-317619-o7qfugjw 83 22 HSV HSV NNP cord-317619-o7qfugjw 83 23 contributes contribute VBZ cord-317619-o7qfugjw 83 24 to to IN cord-317619-o7qfugjw 83 25 worsening worsen VBG cord-317619-o7qfugjw 83 26 illness illness NN cord-317619-o7qfugjw 83 27 or or CC cord-317619-o7qfugjw 83 28 whether whether IN cord-317619-o7qfugjw 83 29 reactivation reactivation NN cord-317619-o7qfugjw 83 30 occurs occur VBZ cord-317619-o7qfugjw 83 31 due due IN cord-317619-o7qfugjw 83 32 to to IN cord-317619-o7qfugjw 83 33 the the DT cord-317619-o7qfugjw 83 34 underlying underlie VBG cord-317619-o7qfugjw 83 35 critical critical JJ cord-317619-o7qfugjw 83 36 illness illness NN cord-317619-o7qfugjw 83 37 ( ( -LRB- cord-317619-o7qfugjw 83 38 50 50 CD cord-317619-o7qfugjw 83 39 ) ) -RRB- cord-317619-o7qfugjw 83 40 . . . cord-317619-o7qfugjw 84 1 Schuller Schuller NNP cord-317619-o7qfugjw 84 2 et et NNP cord-317619-o7qfugjw 84 3 al al NNP cord-317619-o7qfugjw 84 4 . . . cord-317619-o7qfugjw 85 1 found find VBD cord-317619-o7qfugjw 85 2 higher high JJR cord-317619-o7qfugjw 85 3 levels level NNS cord-317619-o7qfugjw 85 4 of of IN cord-317619-o7qfugjw 85 5 clinical clinical JJ cord-317619-o7qfugjw 85 6 severity severity NN cord-317619-o7qfugjw 85 7 and and CC cord-317619-o7qfugjw 85 8 mortality mortality NN cord-317619-o7qfugjw 85 9 in in IN cord-317619-o7qfugjw 85 10 critically critically RB cord-317619-o7qfugjw 85 11 ill ill JJ cord-317619-o7qfugjw 85 12 immunocompetent immunocompetent JJ cord-317619-o7qfugjw 85 13 adults adult NNS cord-317619-o7qfugjw 85 14 with with IN cord-317619-o7qfugjw 85 15 HSV-1 hsv-1 NN cord-317619-o7qfugjw 85 16 infection infection NN cord-317619-o7qfugjw 85 17 compared compare VBN cord-317619-o7qfugjw 85 18 to to IN cord-317619-o7qfugjw 85 19 immunocompromised immunocompromised JJ cord-317619-o7qfugjw 85 20 patients patient NNS cord-317619-o7qfugjw 85 21 with with IN cord-317619-o7qfugjw 85 22 HSV-1 HSV-1 NNS cord-317619-o7qfugjw 85 23 ( ( -LRB- cord-317619-o7qfugjw 85 24 51 51 CD cord-317619-o7qfugjw 85 25 ) ) -RRB- cord-317619-o7qfugjw 85 26 . . . cord-317619-o7qfugjw 86 1 The the DT cord-317619-o7qfugjw 86 2 true true JJ cord-317619-o7qfugjw 86 3 extent extent NN cord-317619-o7qfugjw 86 4 of of IN cord-317619-o7qfugjw 86 5 HSV HSV NNP cord-317619-o7qfugjw 86 6 reactivation reactivation NN cord-317619-o7qfugjw 86 7 in in IN cord-317619-o7qfugjw 86 8 critically critically RB cord-317619-o7qfugjw 86 9 ill ill JJ cord-317619-o7qfugjw 86 10 children child NNS cord-317619-o7qfugjw 86 11 leading lead VBG cord-317619-o7qfugjw 86 12 to to IN cord-317619-o7qfugjw 86 13 respiratory respiratory JJ cord-317619-o7qfugjw 86 14 illness illness NN cord-317619-o7qfugjw 86 15 has have VBZ cord-317619-o7qfugjw 86 16 yet yet RB cord-317619-o7qfugjw 86 17 to to TO cord-317619-o7qfugjw 86 18 be be VB cord-317619-o7qfugjw 86 19 studied study VBN cord-317619-o7qfugjw 86 20 . . . cord-317619-o7qfugjw 87 1 Hennus Hennus NNP cord-317619-o7qfugjw 87 2 et et NNP cord-317619-o7qfugjw 87 3 al al NNP cord-317619-o7qfugjw 87 4 . . . cord-317619-o7qfugjw 88 1 described describe VBD cord-317619-o7qfugjw 88 2 two two CD cord-317619-o7qfugjw 88 3 previously previously RB cord-317619-o7qfugjw 88 4 healthy healthy JJ cord-317619-o7qfugjw 88 5 children child NNS cord-317619-o7qfugjw 88 6 presenting present VBG cord-317619-o7qfugjw 88 7 with with IN cord-317619-o7qfugjw 88 8 respiratory respiratory JJ cord-317619-o7qfugjw 88 9 failure failure NN cord-317619-o7qfugjw 88 10 due due IN cord-317619-o7qfugjw 88 11 to to IN cord-317619-o7qfugjw 88 12 human human JJ cord-317619-o7qfugjw 88 13 herpes herpes NN cord-317619-o7qfugjw 88 14 virus virus NN cord-317619-o7qfugjw 88 15 6 6 CD cord-317619-o7qfugjw 88 16 ( ( -LRB- cord-317619-o7qfugjw 88 17 HHV-6 HHV-6 NNP cord-317619-o7qfugjw 88 18 ) ) -RRB- cord-317619-o7qfugjw 88 19 , , , cord-317619-o7qfugjw 88 20 and and CC cord-317619-o7qfugjw 88 21 later later JJ cord-317619-o7qfugjw 88 22 workup workup NN cord-317619-o7qfugjw 88 23 revealed reveal VBD cord-317619-o7qfugjw 88 24 an an DT cord-317619-o7qfugjw 88 25 immunodeficiency immunodeficiency NN cord-317619-o7qfugjw 88 26 in in IN cord-317619-o7qfugjw 88 27 both both DT cord-317619-o7qfugjw 88 28 patients patient NNS cord-317619-o7qfugjw 88 29 ( ( -LRB- cord-317619-o7qfugjw 88 30 52 52 CD cord-317619-o7qfugjw 88 31 ) ) -RRB- cord-317619-o7qfugjw 88 32 . . . cord-317619-o7qfugjw 89 1 A a DT cord-317619-o7qfugjw 89 2 separate separate JJ cord-317619-o7qfugjw 89 3 pediatric pediatric JJ cord-317619-o7qfugjw 89 4 case case NN cord-317619-o7qfugjw 89 5 reported report VBD cord-317619-o7qfugjw 89 6 a a DT cord-317619-o7qfugjw 89 7 child child NN cord-317619-o7qfugjw 89 8 with with IN cord-317619-o7qfugjw 89 9 HSV HSV NNP cord-317619-o7qfugjw 89 10 ARDS ARDS NNP cord-317619-o7qfugjw 89 11 resulting result VBG cord-317619-o7qfugjw 89 12 in in IN cord-317619-o7qfugjw 89 13 need need NN cord-317619-o7qfugjw 89 14 of of IN cord-317619-o7qfugjw 89 15 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 89 16 support support NN cord-317619-o7qfugjw 89 17 ( ( -LRB- cord-317619-o7qfugjw 89 18 53 53 CD cord-317619-o7qfugjw 89 19 ) ) -RRB- cord-317619-o7qfugjw 89 20 . . . cord-317619-o7qfugjw 90 1 These these DT cord-317619-o7qfugjw 90 2 cases case NNS cord-317619-o7qfugjw 90 3 illustrate illustrate VBP cord-317619-o7qfugjw 90 4 the the DT cord-317619-o7qfugjw 90 5 rare rare JJ cord-317619-o7qfugjw 90 6 , , , cord-317619-o7qfugjw 90 7 but but CC cord-317619-o7qfugjw 90 8 possible possible JJ cord-317619-o7qfugjw 90 9 severe severe JJ cord-317619-o7qfugjw 90 10 infection infection NN cord-317619-o7qfugjw 90 11 and and CC cord-317619-o7qfugjw 90 12 progression progression NN cord-317619-o7qfugjw 90 13 to to IN cord-317619-o7qfugjw 90 14 ARDS ARDS NNP cord-317619-o7qfugjw 90 15 from from IN cord-317619-o7qfugjw 90 16 HSV-1 HSV-1 NNP cord-317619-o7qfugjw 90 17 . . . cord-317619-o7qfugjw 91 1 Finally finally RB cord-317619-o7qfugjw 91 2 , , , cord-317619-o7qfugjw 91 3 many many JJ cord-317619-o7qfugjw 91 4 seasonal seasonal JJ cord-317619-o7qfugjw 91 5 and and CC cord-317619-o7qfugjw 91 6 pandemic pandemic NN cord-317619-o7qfugjw 91 7 viruses virus NNS cord-317619-o7qfugjw 91 8 are be VBP cord-317619-o7qfugjw 91 9 a a DT cord-317619-o7qfugjw 91 10 potential potential JJ cord-317619-o7qfugjw 91 11 nosocomial nosocomial JJ cord-317619-o7qfugjw 91 12 infectious infectious JJ cord-317619-o7qfugjw 91 13 risk risk NN cord-317619-o7qfugjw 91 14 secondary secondary JJ cord-317619-o7qfugjw 91 15 to to IN cord-317619-o7qfugjw 91 16 either either CC cord-317619-o7qfugjw 91 17 a a DT cord-317619-o7qfugjw 91 18 health health NN cord-317619-o7qfugjw 91 19 - - HYPH cord-317619-o7qfugjw 91 20 care care NN cord-317619-o7qfugjw 91 21 provider provider NN cord-317619-o7qfugjw 91 22 or or CC cord-317619-o7qfugjw 91 23 air air NN cord-317619-o7qfugjw 91 24 - - HYPH cord-317619-o7qfugjw 91 25 ventilation ventilation NN cord-317619-o7qfugjw 91 26 transmission transmission NN cord-317619-o7qfugjw 91 27 . . . cord-317619-o7qfugjw 92 1 In in IN cord-317619-o7qfugjw 92 2 a a DT cord-317619-o7qfugjw 92 3 study study NN cord-317619-o7qfugjw 92 4 over over IN cord-317619-o7qfugjw 92 5 two two CD cord-317619-o7qfugjw 92 6 influenza influenza NN cord-317619-o7qfugjw 92 7 seasons season NNS cord-317619-o7qfugjw 92 8 in in IN cord-317619-o7qfugjw 92 9 Germany Germany NNP cord-317619-o7qfugjw 92 10 , , , cord-317619-o7qfugjw 92 11 Huzly Huzly NNP cord-317619-o7qfugjw 92 12 et et NNP cord-317619-o7qfugjw 92 13 al al NNP cord-317619-o7qfugjw 92 14 . . NNP cord-317619-o7qfugjw 92 15 reported report VBD cord-317619-o7qfugjw 92 16 a a DT cord-317619-o7qfugjw 92 17 rate rate NN cord-317619-o7qfugjw 92 18 of of IN cord-317619-o7qfugjw 92 19 nosocomial nosocomial JJ cord-317619-o7qfugjw 92 20 transmission transmission NN cord-317619-o7qfugjw 92 21 of of IN cord-317619-o7qfugjw 92 22 24 24 CD cord-317619-o7qfugjw 92 23 % % NN cord-317619-o7qfugjw 92 24 ( ( -LRB- cord-317619-o7qfugjw 92 25 2012 2012 CD cord-317619-o7qfugjw 92 26 - - SYM cord-317619-o7qfugjw 92 27 2013 2013 CD cord-317619-o7qfugjw 92 28 ) ) -RRB- cord-317619-o7qfugjw 92 29 and and CC cord-317619-o7qfugjw 92 30 20 20 CD cord-317619-o7qfugjw 92 31 % % NN cord-317619-o7qfugjw 92 32 ( ( -LRB- cord-317619-o7qfugjw 92 33 2013 2013 CD cord-317619-o7qfugjw 92 34 - - SYM cord-317619-o7qfugjw 92 35 2014 2014 CD cord-317619-o7qfugjw 92 36 ) ) -RRB- cord-317619-o7qfugjw 92 37 ( ( -LRB- cord-317619-o7qfugjw 92 38 54 54 CD cord-317619-o7qfugjw 92 39 ) ) -RRB- cord-317619-o7qfugjw 92 40 . . . cord-317619-o7qfugjw 93 1 Specific specific JJ cord-317619-o7qfugjw 93 2 guidelines guideline NNS cord-317619-o7qfugjw 93 3 are be VBP cord-317619-o7qfugjw 93 4 available available JJ cord-317619-o7qfugjw 93 5 to to TO cord-317619-o7qfugjw 93 6 help help VB cord-317619-o7qfugjw 93 7 prevent prevent VB cord-317619-o7qfugjw 93 8 transmission transmission NN cord-317619-o7qfugjw 93 9 of of IN cord-317619-o7qfugjw 93 10 infectious infectious JJ cord-317619-o7qfugjw 93 11 pathogens pathogen NNS cord-317619-o7qfugjw 93 12 through through IN cord-317619-o7qfugjw 93 13 isolation isolation NN cord-317619-o7qfugjw 93 14 precautions precaution NNS cord-317619-o7qfugjw 93 15 ( ( -LRB- cord-317619-o7qfugjw 93 16 55 55 CD cord-317619-o7qfugjw 93 17 ) ) -RRB- cord-317619-o7qfugjw 93 18 . . . cord-317619-o7qfugjw 94 1 However however RB cord-317619-o7qfugjw 94 2 , , , cord-317619-o7qfugjw 94 3 Dhar Dhar NNP cord-317619-o7qfugjw 94 4 et et NNP cord-317619-o7qfugjw 94 5 al al NNP cord-317619-o7qfugjw 94 6 . . NNP cord-317619-o7qfugjw 94 7 found find VBD cord-317619-o7qfugjw 94 8 that that IN cord-317619-o7qfugjw 94 9 an an DT cord-317619-o7qfugjw 94 10 increased increase VBN cord-317619-o7qfugjw 94 11 number number NN cord-317619-o7qfugjw 94 12 in in IN cord-317619-o7qfugjw 94 13 patients patient NNS cord-317619-o7qfugjw 94 14 placed place VBN cord-317619-o7qfugjw 94 15 on on IN cord-317619-o7qfugjw 94 16 contact contact NN cord-317619-o7qfugjw 94 17 isolation isolation NN cord-317619-o7qfugjw 94 18 led lead VBD cord-317619-o7qfugjw 94 19 to to IN cord-317619-o7qfugjw 94 20 a a DT cord-317619-o7qfugjw 94 21 decrease decrease NN cord-317619-o7qfugjw 94 22 in in IN cord-317619-o7qfugjw 94 23 compliance compliance NN cord-317619-o7qfugjw 94 24 with with IN cord-317619-o7qfugjw 94 25 isolation isolation NN cord-317619-o7qfugjw 94 26 precautions precaution NNS cord-317619-o7qfugjw 94 27 ( ( -LRB- cord-317619-o7qfugjw 94 28 56 56 CD cord-317619-o7qfugjw 94 29 ) ) -RRB- cord-317619-o7qfugjw 94 30 . . . cord-317619-o7qfugjw 95 1 Decreasing decrease VBG cord-317619-o7qfugjw 95 2 nosocomial nosocomial JJ cord-317619-o7qfugjw 95 3 transmission transmission NN cord-317619-o7qfugjw 95 4 within within IN cord-317619-o7qfugjw 95 5 care care NN cord-317619-o7qfugjw 95 6 areas area NNS cord-317619-o7qfugjw 95 7 for for IN cord-317619-o7qfugjw 95 8 critically critically RB cord-317619-o7qfugjw 95 9 ill ill JJ cord-317619-o7qfugjw 95 10 patients patient NNS cord-317619-o7qfugjw 95 11 is be VBZ cord-317619-o7qfugjw 95 12 an an DT cord-317619-o7qfugjw 95 13 important important JJ cord-317619-o7qfugjw 95 14 area area NN cord-317619-o7qfugjw 95 15 for for IN cord-317619-o7qfugjw 95 16 improvement improvement NN cord-317619-o7qfugjw 95 17 . . . cord-317619-o7qfugjw 96 1 The the DT cord-317619-o7qfugjw 96 2 PALICC PALICC NNP cord-317619-o7qfugjw 96 3 has have VBZ cord-317619-o7qfugjw 96 4 recently recently RB cord-317619-o7qfugjw 96 5 provided provide VBN cord-317619-o7qfugjw 96 6 guidelines guideline NNS cord-317619-o7qfugjw 96 7 for for IN cord-317619-o7qfugjw 96 8 diagnosing diagnose VBG cord-317619-o7qfugjw 96 9 pediatric pediatric JJ cord-317619-o7qfugjw 96 10 ARDS ARDS NNP cord-317619-o7qfugjw 96 11 ( ( -LRB- cord-317619-o7qfugjw 96 12 5 5 CD cord-317619-o7qfugjw 96 13 ) ) -RRB- cord-317619-o7qfugjw 96 14 . . . cord-317619-o7qfugjw 97 1 The the DT cord-317619-o7qfugjw 97 2 new new JJ cord-317619-o7qfugjw 97 3 guidelines guideline NNS cord-317619-o7qfugjw 97 4 define define VBP cord-317619-o7qfugjw 97 5 important important JJ cord-317619-o7qfugjw 97 6 diagnostic diagnostic JJ cord-317619-o7qfugjw 97 7 criteria criterion NNS cord-317619-o7qfugjw 97 8 , , , cord-317619-o7qfugjw 97 9 including include VBG cord-317619-o7qfugjw 97 10 age age NN cord-317619-o7qfugjw 97 11 , , , cord-317619-o7qfugjw 97 12 timing timing NN cord-317619-o7qfugjw 97 13 , , , cord-317619-o7qfugjw 97 14 origin origin NN cord-317619-o7qfugjw 97 15 of of IN cord-317619-o7qfugjw 97 16 edema edema NN cord-317619-o7qfugjw 97 17 , , , cord-317619-o7qfugjw 97 18 imaging imaging NN cord-317619-o7qfugjw 97 19 , , , cord-317619-o7qfugjw 97 20 and and CC cord-317619-o7qfugjw 97 21 oxygenation oxygenation NN cord-317619-o7qfugjw 97 22 . . . cord-317619-o7qfugjw 98 1 Patients patient NNS cord-317619-o7qfugjw 98 2 with with IN cord-317619-o7qfugjw 98 3 perinatal perinatal JJ cord-317619-o7qfugjw 98 4 lung lung NN cord-317619-o7qfugjw 98 5 disease disease NN cord-317619-o7qfugjw 98 6 are be VBP cord-317619-o7qfugjw 98 7 excluded exclude VBN cord-317619-o7qfugjw 98 8 , , , cord-317619-o7qfugjw 98 9 and and CC cord-317619-o7qfugjw 98 10 pARDS pARDS NNP cord-317619-o7qfugjw 98 11 criteria criterion NNS cord-317619-o7qfugjw 98 12 must must MD cord-317619-o7qfugjw 98 13 be be VB cord-317619-o7qfugjw 98 14 met meet VBN cord-317619-o7qfugjw 98 15 within within IN cord-317619-o7qfugjw 98 16 7 7 CD cord-317619-o7qfugjw 98 17 days day NNS cord-317619-o7qfugjw 98 18 of of IN cord-317619-o7qfugjw 98 19 a a DT cord-317619-o7qfugjw 98 20 clinical clinical JJ cord-317619-o7qfugjw 98 21 insult insult NN cord-317619-o7qfugjw 98 22 . . . cord-317619-o7qfugjw 99 1 The the DT cord-317619-o7qfugjw 99 2 cause cause NN cord-317619-o7qfugjw 99 3 of of IN cord-317619-o7qfugjw 99 4 respiratory respiratory JJ cord-317619-o7qfugjw 99 5 failure failure NN cord-317619-o7qfugjw 99 6 must must MD cord-317619-o7qfugjw 99 7 not not RB cord-317619-o7qfugjw 99 8 be be VB cord-317619-o7qfugjw 99 9 explained explain VBN cord-317619-o7qfugjw 99 10 by by IN cord-317619-o7qfugjw 99 11 heart heart NN cord-317619-o7qfugjw 99 12 failure failure NN cord-317619-o7qfugjw 99 13 or or CC cord-317619-o7qfugjw 99 14 fluid fluid JJ cord-317619-o7qfugjw 99 15 overload overload NN cord-317619-o7qfugjw 99 16 , , , cord-317619-o7qfugjw 99 17 and and CC cord-317619-o7qfugjw 99 18 must must MD cord-317619-o7qfugjw 99 19 be be VB cord-317619-o7qfugjw 99 20 evidenced evidence VBN cord-317619-o7qfugjw 99 21 by by IN cord-317619-o7qfugjw 99 22 new new JJ cord-317619-o7qfugjw 99 23 pulmonary pulmonary NN cord-317619-o7qfugjw 99 24 infiltrate(s infiltrate(s NNP cord-317619-o7qfugjw 99 25 ) ) -RRB- cord-317619-o7qfugjw 99 26 on on IN cord-317619-o7qfugjw 99 27 chest chest NN cord-317619-o7qfugjw 99 28 radiograph radiograph NN cord-317619-o7qfugjw 99 29 consistent consistent JJ cord-317619-o7qfugjw 99 30 with with IN cord-317619-o7qfugjw 99 31 parenchymal parenchymal JJ cord-317619-o7qfugjw 99 32 disease disease NN cord-317619-o7qfugjw 99 33 . . . cord-317619-o7qfugjw 100 1 Finally finally RB cord-317619-o7qfugjw 100 2 , , , cord-317619-o7qfugjw 100 3 the the DT cord-317619-o7qfugjw 100 4 use use NN cord-317619-o7qfugjw 100 5 of of IN cord-317619-o7qfugjw 100 6 oxygenation oxygenation NN cord-317619-o7qfugjw 100 7 index index NN cord-317619-o7qfugjw 100 8 is be VBZ cord-317619-o7qfugjw 100 9 preferred prefer VBN cord-317619-o7qfugjw 100 10 over over IN cord-317619-o7qfugjw 100 11 the the DT cord-317619-o7qfugjw 100 12 PaO2 pao2 NN cord-317619-o7qfugjw 100 13 : : : cord-317619-o7qfugjw 101 1 FiO2 FiO2 NNP cord-317619-o7qfugjw 101 2 ( ( -LRB- cord-317619-o7qfugjw 101 3 PF PF NNP cord-317619-o7qfugjw 101 4 ) ) -RRB- cord-317619-o7qfugjw 101 5 ratio ratio NN cord-317619-o7qfugjw 101 6 in in IN cord-317619-o7qfugjw 101 7 determining determine VBG cord-317619-o7qfugjw 101 8 the the DT cord-317619-o7qfugjw 101 9 severity severity NN cord-317619-o7qfugjw 101 10 of of IN cord-317619-o7qfugjw 101 11 pARDS pARDS NNP cord-317619-o7qfugjw 101 12 in in IN cord-317619-o7qfugjw 101 13 mechanically mechanically RB cord-317619-o7qfugjw 101 14 ventilated ventilate VBN cord-317619-o7qfugjw 101 15 patients patient NNS cord-317619-o7qfugjw 101 16 , , , cord-317619-o7qfugjw 101 17 while while IN cord-317619-o7qfugjw 101 18 the the DT cord-317619-o7qfugjw 101 19 PF PF NNP cord-317619-o7qfugjw 101 20 ratio ratio NN cord-317619-o7qfugjw 101 21 or or CC cord-317619-o7qfugjw 101 22 SpO2 SpO2 NNS cord-317619-o7qfugjw 101 23 : : : cord-317619-o7qfugjw 101 24 FiO2 FiO2 NNP cord-317619-o7qfugjw 101 25 ( ( -LRB- cord-317619-o7qfugjw 101 26 SF SF NNP cord-317619-o7qfugjw 101 27 ) ) -RRB- cord-317619-o7qfugjw 101 28 ratio ratio NN cord-317619-o7qfugjw 101 29 may may MD cord-317619-o7qfugjw 101 30 be be VB cord-317619-o7qfugjw 101 31 used use VBN cord-317619-o7qfugjw 101 32 in in IN cord-317619-o7qfugjw 101 33 patients patient NNS cord-317619-o7qfugjw 101 34 requiring require VBG cord-317619-o7qfugjw 101 35 non non JJ cord-317619-o7qfugjw 101 36 - - JJ cord-317619-o7qfugjw 101 37 invasive invasive JJ cord-317619-o7qfugjw 101 38 ventilation ventilation NN cord-317619-o7qfugjw 101 39 ( ( -LRB- cord-317619-o7qfugjw 101 40 5 5 CD cord-317619-o7qfugjw 101 41 ) ) -RRB- cord-317619-o7qfugjw 101 42 . . . cord-317619-o7qfugjw 102 1 The the DT cord-317619-o7qfugjw 102 2 same same JJ cord-317619-o7qfugjw 102 3 clinical clinical JJ cord-317619-o7qfugjw 102 4 guideline guideline NN cord-317619-o7qfugjw 102 5 is be VBZ cord-317619-o7qfugjw 102 6 used use VBN cord-317619-o7qfugjw 102 7 in in IN cord-317619-o7qfugjw 102 8 the the DT cord-317619-o7qfugjw 102 9 diagnosis diagnosis NN cord-317619-o7qfugjw 102 10 of of IN cord-317619-o7qfugjw 102 11 viral viral RB cord-317619-o7qfugjw 102 12 - - HYPH cord-317619-o7qfugjw 102 13 induced induce VBN cord-317619-o7qfugjw 102 14 pediatric pediatric JJ cord-317619-o7qfugjw 102 15 ARDS ARDS NNP cord-317619-o7qfugjw 102 16 . . . cord-317619-o7qfugjw 103 1 Currently currently RB cord-317619-o7qfugjw 103 2 , , , cord-317619-o7qfugjw 103 3 there there EX cord-317619-o7qfugjw 103 4 are be VBP cord-317619-o7qfugjw 103 5 several several JJ cord-317619-o7qfugjw 103 6 different different JJ cord-317619-o7qfugjw 103 7 types type NNS cord-317619-o7qfugjw 103 8 of of IN cord-317619-o7qfugjw 103 9 laboratory laboratory NN cord-317619-o7qfugjw 103 10 tests test NNS cord-317619-o7qfugjw 103 11 that that WDT cord-317619-o7qfugjw 103 12 are be VBP cord-317619-o7qfugjw 103 13 commercially commercially RB cord-317619-o7qfugjw 103 14 available available JJ cord-317619-o7qfugjw 103 15 for for IN cord-317619-o7qfugjw 103 16 diagnosis diagnosis NN cord-317619-o7qfugjw 103 17 . . . cord-317619-o7qfugjw 104 1 Most Most JJS cord-317619-o7qfugjw 104 2 clinical clinical JJ cord-317619-o7qfugjw 104 3 laboratories laboratory NNS cord-317619-o7qfugjw 104 4 utilize utilize VBP cord-317619-o7qfugjw 104 5 antigen antigen NN cord-317619-o7qfugjw 104 6 detection detection NN cord-317619-o7qfugjw 104 7 tests test NNS cord-317619-o7qfugjw 104 8 , , , cord-317619-o7qfugjw 104 9 which which WDT cord-317619-o7qfugjw 104 10 consist consist VBP cord-317619-o7qfugjw 104 11 of of IN cord-317619-o7qfugjw 104 12 multiple multiple JJ cord-317619-o7qfugjw 104 13 steps step NNS cord-317619-o7qfugjw 104 14 to to TO cord-317619-o7qfugjw 104 15 accurately accurately RB cord-317619-o7qfugjw 104 16 identify identify VB cord-317619-o7qfugjw 104 17 a a DT cord-317619-o7qfugjw 104 18 single single JJ cord-317619-o7qfugjw 104 19 virus virus NN cord-317619-o7qfugjw 104 20 ( ( -LRB- cord-317619-o7qfugjw 104 21 57 57 CD cord-317619-o7qfugjw 104 22 ) ) -RRB- cord-317619-o7qfugjw 104 23 , , , cord-317619-o7qfugjw 104 24 with with IN cord-317619-o7qfugjw 104 25 or or CC cord-317619-o7qfugjw 104 26 without without IN cord-317619-o7qfugjw 104 27 cell cell NN cord-317619-o7qfugjw 104 28 culture culture NN cord-317619-o7qfugjw 104 29 . . . cord-317619-o7qfugjw 105 1 It -PRON- PRP cord-317619-o7qfugjw 105 2 is be VBZ cord-317619-o7qfugjw 105 3 worth worth JJ cord-317619-o7qfugjw 105 4 noting note VBG cord-317619-o7qfugjw 105 5 that that IN cord-317619-o7qfugjw 105 6 over over IN cord-317619-o7qfugjw 105 7 the the DT cord-317619-o7qfugjw 105 8 past past JJ cord-317619-o7qfugjw 105 9 20 20 CD cord-317619-o7qfugjw 105 10 years year NNS cord-317619-o7qfugjw 105 11 , , , cord-317619-o7qfugjw 105 12 the the DT cord-317619-o7qfugjw 105 13 development development NN cord-317619-o7qfugjw 105 14 and and CC cord-317619-o7qfugjw 105 15 refinement refinement NN cord-317619-o7qfugjw 105 16 of of IN cord-317619-o7qfugjw 105 17 real real JJ cord-317619-o7qfugjw 105 18 - - HYPH cord-317619-o7qfugjw 105 19 time time NN cord-317619-o7qfugjw 105 20 reverse reverse JJ cord-317619-o7qfugjw 105 21 transcriptase transcriptase NN cord-317619-o7qfugjw 105 22 polymerase polymerase NN cord-317619-o7qfugjw 105 23 chain chain NN cord-317619-o7qfugjw 105 24 reaction reaction NN cord-317619-o7qfugjw 105 25 ( ( -LRB- cord-317619-o7qfugjw 105 26 RT RT NNP cord-317619-o7qfugjw 105 27 - - HYPH cord-317619-o7qfugjw 105 28 PCR PCR NNP cord-317619-o7qfugjw 105 29 ) ) -RRB- cord-317619-o7qfugjw 105 30 has have VBZ cord-317619-o7qfugjw 105 31 enhanced enhance VBN cord-317619-o7qfugjw 105 32 the the DT cord-317619-o7qfugjw 105 33 clinician clinician NN cord-317619-o7qfugjw 105 34 's 's POS cord-317619-o7qfugjw 105 35 ability ability NN cord-317619-o7qfugjw 105 36 to to TO cord-317619-o7qfugjw 105 37 diagnose diagnose VB cord-317619-o7qfugjw 105 38 an an DT cord-317619-o7qfugjw 105 39 array array NN cord-317619-o7qfugjw 105 40 of of IN cord-317619-o7qfugjw 105 41 viruses virus NNS cord-317619-o7qfugjw 105 42 rapidly rapidly RB cord-317619-o7qfugjw 105 43 and and CC cord-317619-o7qfugjw 105 44 accurately accurately RB cord-317619-o7qfugjw 105 45 . . . cord-317619-o7qfugjw 106 1 Multiplex multiplex JJ cord-317619-o7qfugjw 106 2 RT RT NNP cord-317619-o7qfugjw 106 3 - - HYPH cord-317619-o7qfugjw 106 4 PCR PCR NNP cord-317619-o7qfugjw 106 5 testing testing NN cord-317619-o7qfugjw 106 6 analyzes analyze VBZ cord-317619-o7qfugjw 106 7 a a DT cord-317619-o7qfugjw 106 8 single single JJ cord-317619-o7qfugjw 106 9 sample sample NN cord-317619-o7qfugjw 106 10 for for IN cord-317619-o7qfugjw 106 11 multiple multiple JJ cord-317619-o7qfugjw 106 12 viral viral JJ cord-317619-o7qfugjw 106 13 agents agent NNS cord-317619-o7qfugjw 106 14 and and CC cord-317619-o7qfugjw 106 15 subtypes subtype NNS cord-317619-o7qfugjw 106 16 simultaneously simultaneously RB cord-317619-o7qfugjw 106 17 , , , cord-317619-o7qfugjw 106 18 producing produce VBG cord-317619-o7qfugjw 106 19 sensitive sensitive JJ cord-317619-o7qfugjw 106 20 and and CC cord-317619-o7qfugjw 106 21 specific specific JJ cord-317619-o7qfugjw 106 22 results result NNS cord-317619-o7qfugjw 106 23 in in IN cord-317619-o7qfugjw 106 24 a a DT cord-317619-o7qfugjw 106 25 short short JJ cord-317619-o7qfugjw 106 26 period period NN cord-317619-o7qfugjw 106 27 of of IN cord-317619-o7qfugjw 106 28 time time NN cord-317619-o7qfugjw 106 29 ( ( -LRB- cord-317619-o7qfugjw 106 30 58 58 CD cord-317619-o7qfugjw 106 31 ) ) -RRB- cord-317619-o7qfugjw 106 32 . . . cord-317619-o7qfugjw 107 1 Even even RB cord-317619-o7qfugjw 107 2 with with IN cord-317619-o7qfugjw 107 3 the the DT cord-317619-o7qfugjw 107 4 2009 2009 CD cord-317619-o7qfugjw 107 5 influenza influenza NN cord-317619-o7qfugjw 107 6 A a NN cord-317619-o7qfugjw 107 7 ( ( -LRB- cord-317619-o7qfugjw 107 8 H1N1 H1N1 NNP cord-317619-o7qfugjw 107 9 ) ) -RRB- cord-317619-o7qfugjw 107 10 virus virus NN cord-317619-o7qfugjw 107 11 pandemic pandemic NN cord-317619-o7qfugjw 107 12 , , , cord-317619-o7qfugjw 107 13 the the DT cord-317619-o7qfugjw 107 14 Centers Centers NNPS cord-317619-o7qfugjw 107 15 for for IN cord-317619-o7qfugjw 107 16 Disease Disease NNP cord-317619-o7qfugjw 107 17 Control Control NNP cord-317619-o7qfugjw 107 18 and and CC cord-317619-o7qfugjw 107 19 Prevention Prevention NNP cord-317619-o7qfugjw 107 20 ( ( -LRB- cord-317619-o7qfugjw 107 21 CDC CDC NNP cord-317619-o7qfugjw 107 22 ) ) -RRB- cord-317619-o7qfugjw 107 23 quickly quickly RB cord-317619-o7qfugjw 107 24 modified modify VBD cord-317619-o7qfugjw 107 25 standard standard NN cord-317619-o7qfugjw 107 26 PCR PCR NNP cord-317619-o7qfugjw 107 27 assays assay NNS cord-317619-o7qfugjw 107 28 to to TO cord-317619-o7qfugjw 107 29 detect detect VB cord-317619-o7qfugjw 107 30 the the DT cord-317619-o7qfugjw 107 31 new new JJ cord-317619-o7qfugjw 107 32 virus virus NN cord-317619-o7qfugjw 107 33 ( ( -LRB- cord-317619-o7qfugjw 107 34 59 59 CD cord-317619-o7qfugjw 107 35 ) ) -RRB- cord-317619-o7qfugjw 107 36 . . . cord-317619-o7qfugjw 108 1 A a DT cord-317619-o7qfugjw 108 2 challenge challenge NN cord-317619-o7qfugjw 108 3 to to IN cord-317619-o7qfugjw 108 4 routine routine JJ cord-317619-o7qfugjw 108 5 RT RT NNP cord-317619-o7qfugjw 108 6 - - HYPH cord-317619-o7qfugjw 108 7 PCR PCR NNP cord-317619-o7qfugjw 108 8 testing testing NN cord-317619-o7qfugjw 108 9 in in IN cord-317619-o7qfugjw 108 10 all all DT cord-317619-o7qfugjw 108 11 patients patient NNS cord-317619-o7qfugjw 108 12 who who WP cord-317619-o7qfugjw 108 13 present present VBP cord-317619-o7qfugjw 108 14 with with IN cord-317619-o7qfugjw 108 15 viral viral JJ cord-317619-o7qfugjw 108 16 symptoms symptom NNS cord-317619-o7qfugjw 108 17 is be VBZ cord-317619-o7qfugjw 108 18 the the DT cord-317619-o7qfugjw 108 19 prohibitive prohibitive JJ cord-317619-o7qfugjw 108 20 cost cost NN cord-317619-o7qfugjw 108 21 , , , cord-317619-o7qfugjw 108 22 need need VBP cord-317619-o7qfugjw 108 23 for for IN cord-317619-o7qfugjw 108 24 specialized specialized JJ cord-317619-o7qfugjw 108 25 equipment equipment NN cord-317619-o7qfugjw 108 26 , , , cord-317619-o7qfugjw 108 27 and and CC cord-317619-o7qfugjw 108 28 the the DT cord-317619-o7qfugjw 108 29 relatively relatively RB cord-317619-o7qfugjw 108 30 longer long JJR cord-317619-o7qfugjw 108 31 time time NN cord-317619-o7qfugjw 108 32 between between IN cord-317619-o7qfugjw 108 33 sampling sampling NN cord-317619-o7qfugjw 108 34 and and CC cord-317619-o7qfugjw 108 35 availability availability NN cord-317619-o7qfugjw 108 36 of of IN cord-317619-o7qfugjw 108 37 results result NNS cord-317619-o7qfugjw 108 38 ( ( -LRB- cord-317619-o7qfugjw 108 39 60 60 CD cord-317619-o7qfugjw 108 40 ) ) -RRB- cord-317619-o7qfugjw 108 41 . . . cord-317619-o7qfugjw 109 1 Furthermore furthermore RB cord-317619-o7qfugjw 109 2 , , , cord-317619-o7qfugjw 109 3 PCRs pcr NNS cord-317619-o7qfugjw 109 4 detect detect VBP cord-317619-o7qfugjw 109 5 viral viral JJ cord-317619-o7qfugjw 109 6 genes gene NNS cord-317619-o7qfugjw 109 7 that that WDT cord-317619-o7qfugjw 109 8 are be VBP cord-317619-o7qfugjw 109 9 used use VBN cord-317619-o7qfugjw 109 10 as as IN cord-317619-o7qfugjw 109 11 a a DT cord-317619-o7qfugjw 109 12 surrogate surrogate JJ cord-317619-o7qfugjw 109 13 measurement measurement NN cord-317619-o7qfugjw 109 14 of of IN cord-317619-o7qfugjw 109 15 whole whole JJ cord-317619-o7qfugjw 109 16 virions virion NNS cord-317619-o7qfugjw 109 17 . . . cord-317619-o7qfugjw 110 1 In in IN cord-317619-o7qfugjw 110 2 some some DT cord-317619-o7qfugjw 110 3 instances instance NNS cord-317619-o7qfugjw 110 4 , , , cord-317619-o7qfugjw 110 5 viral viral JJ cord-317619-o7qfugjw 110 6 gene gene NN cord-317619-o7qfugjw 110 7 detection detection NN cord-317619-o7qfugjw 110 8 may may MD cord-317619-o7qfugjw 110 9 actually actually RB cord-317619-o7qfugjw 110 10 reflect reflect VB cord-317619-o7qfugjw 110 11 non non JJ cord-317619-o7qfugjw 110 12 - - JJ cord-317619-o7qfugjw 110 13 replicating replicating JJ cord-317619-o7qfugjw 110 14 , , , cord-317619-o7qfugjw 110 15 non non JJ cord-317619-o7qfugjw 110 16 - - JJ cord-317619-o7qfugjw 110 17 infectious infectious JJ cord-317619-o7qfugjw 110 18 virions virion NNS cord-317619-o7qfugjw 110 19 . . . cord-317619-o7qfugjw 111 1 Newer new JJR cord-317619-o7qfugjw 111 2 rapid rapid JJ cord-317619-o7qfugjw 111 3 point point NN cord-317619-o7qfugjw 111 4 - - HYPH cord-317619-o7qfugjw 111 5 of of IN cord-317619-o7qfugjw 111 6 - - HYPH cord-317619-o7qfugjw 111 7 care care NN cord-317619-o7qfugjw 111 8 PCRs pcr NNS cord-317619-o7qfugjw 111 9 are be VBP cord-317619-o7qfugjw 111 10 currently currently RB cord-317619-o7qfugjw 111 11 being be VBG cord-317619-o7qfugjw 111 12 developed develop VBN cord-317619-o7qfugjw 111 13 , , , cord-317619-o7qfugjw 111 14 but but CC cord-317619-o7qfugjw 111 15 their -PRON- PRP$ cord-317619-o7qfugjw 111 16 implications implication NNS cord-317619-o7qfugjw 111 17 for for IN cord-317619-o7qfugjw 111 18 clinical clinical JJ cord-317619-o7qfugjw 111 19 decision decision NN cord-317619-o7qfugjw 111 20 making make VBG cord-317619-o7qfugjw 111 21 remain remain VBP cord-317619-o7qfugjw 111 22 uncertain uncertain JJ cord-317619-o7qfugjw 111 23 ( ( -LRB- cord-317619-o7qfugjw 111 24 61 61 CD cord-317619-o7qfugjw 111 25 ) ) -RRB- cord-317619-o7qfugjw 111 26 . . . cord-317619-o7qfugjw 112 1 In in IN cord-317619-o7qfugjw 112 2 addition addition NN cord-317619-o7qfugjw 112 3 , , , cord-317619-o7qfugjw 112 4 rapid rapid JJ cord-317619-o7qfugjw 112 5 antigen antigen NN cord-317619-o7qfugjw 112 6 detection detection NN cord-317619-o7qfugjw 112 7 tests test NNS cord-317619-o7qfugjw 112 8 ( ( -LRB- cord-317619-o7qfugjw 112 9 RADT RADT NNP cord-317619-o7qfugjw 112 10 ) ) -RRB- cord-317619-o7qfugjw 112 11 are be VBP cord-317619-o7qfugjw 112 12 also also RB cord-317619-o7qfugjw 112 13 available available JJ cord-317619-o7qfugjw 112 14 commercially commercially RB cord-317619-o7qfugjw 112 15 for for IN cord-317619-o7qfugjw 112 16 detection detection NN cord-317619-o7qfugjw 112 17 of of IN cord-317619-o7qfugjw 112 18 both both CC cord-317619-o7qfugjw 112 19 RSV RSV NNP cord-317619-o7qfugjw 112 20 and and CC cord-317619-o7qfugjw 112 21 influenza influenza NN cord-317619-o7qfugjw 112 22 virus virus NN cord-317619-o7qfugjw 112 23 infection infection NN cord-317619-o7qfugjw 112 24 in in IN cord-317619-o7qfugjw 112 25 the the DT cord-317619-o7qfugjw 112 26 outpatient outpatient NN cord-317619-o7qfugjw 112 27 and and CC cord-317619-o7qfugjw 112 28 emergency emergency NN cord-317619-o7qfugjw 112 29 department department NN cord-317619-o7qfugjw 112 30 settings setting NNS cord-317619-o7qfugjw 112 31 ( ( -LRB- cord-317619-o7qfugjw 112 32 62 62 CD cord-317619-o7qfugjw 112 33 , , , cord-317619-o7qfugjw 112 34 63 63 CD cord-317619-o7qfugjw 112 35 ) ) -RRB- cord-317619-o7qfugjw 112 36 . . . cord-317619-o7qfugjw 113 1 However however RB cord-317619-o7qfugjw 113 2 , , , cord-317619-o7qfugjw 113 3 in in IN cord-317619-o7qfugjw 113 4 a a DT cord-317619-o7qfugjw 113 5 recent recent JJ cord-317619-o7qfugjw 113 6 study study NN cord-317619-o7qfugjw 113 7 by by IN cord-317619-o7qfugjw 113 8 Moesker Moesker NNP cord-317619-o7qfugjw 113 9 et et NNP cord-317619-o7qfugjw 113 10 al al NNP cord-317619-o7qfugjw 113 11 . . . cord-317619-o7qfugjw 114 1 , , , cord-317619-o7qfugjw 114 2 RADTs RADTs NNPS cord-317619-o7qfugjw 114 3 were be VBD cord-317619-o7qfugjw 114 4 found find VBN cord-317619-o7qfugjw 114 5 to to TO cord-317619-o7qfugjw 114 6 have have VB cord-317619-o7qfugjw 114 7 relatively relatively RB cord-317619-o7qfugjw 114 8 low low JJ cord-317619-o7qfugjw 114 9 sensitivity sensitivity NN cord-317619-o7qfugjw 114 10 compared compare VBN cord-317619-o7qfugjw 114 11 to to IN cord-317619-o7qfugjw 114 12 RT RT NNP cord-317619-o7qfugjw 114 13 - - HYPH cord-317619-o7qfugjw 114 14 PCR PCR NNP cord-317619-o7qfugjw 114 15 testing testing NN cord-317619-o7qfugjw 114 16 which which WDT cord-317619-o7qfugjw 114 17 limits limit VBZ cord-317619-o7qfugjw 114 18 their -PRON- PRP$ cord-317619-o7qfugjw 114 19 use use NN cord-317619-o7qfugjw 114 20 for for IN cord-317619-o7qfugjw 114 21 clinical clinical JJ cord-317619-o7qfugjw 114 22 decision decision NN cord-317619-o7qfugjw 114 23 making make VBG cord-317619-o7qfugjw 114 24 ( ( -LRB- cord-317619-o7qfugjw 114 25 64 64 CD cord-317619-o7qfugjw 114 26 ) ) -RRB- cord-317619-o7qfugjw 114 27 . . . cord-317619-o7qfugjw 115 1 Nonetheless nonetheless RB cord-317619-o7qfugjw 115 2 , , , cord-317619-o7qfugjw 115 3 RADT RADT NNP cord-317619-o7qfugjw 115 4 maybe maybe RB cord-317619-o7qfugjw 115 5 a a DT cord-317619-o7qfugjw 115 6 valuable valuable JJ cord-317619-o7qfugjw 115 7 tool tool NN cord-317619-o7qfugjw 115 8 , , , cord-317619-o7qfugjw 115 9 especially especially RB cord-317619-o7qfugjw 115 10 during during IN cord-317619-o7qfugjw 115 11 an an DT cord-317619-o7qfugjw 115 12 outbreak outbreak NN cord-317619-o7qfugjw 115 13 , , , cord-317619-o7qfugjw 115 14 because because IN cord-317619-o7qfugjw 115 15 it -PRON- PRP cord-317619-o7qfugjw 115 16 is be VBZ cord-317619-o7qfugjw 115 17 a a DT cord-317619-o7qfugjw 115 18 point point NN cord-317619-o7qfugjw 115 19 - - HYPH cord-317619-o7qfugjw 115 20 of of IN cord-317619-o7qfugjw 115 21 - - HYPH cord-317619-o7qfugjw 115 22 care care NN cord-317619-o7qfugjw 115 23 test test NN cord-317619-o7qfugjw 115 24 that that WDT cord-317619-o7qfugjw 115 25 is be VBZ cord-317619-o7qfugjw 115 26 easy easy JJ cord-317619-o7qfugjw 115 27 to to TO cord-317619-o7qfugjw 115 28 use use VB cord-317619-o7qfugjw 115 29 with with IN cord-317619-o7qfugjw 115 30 a a DT cord-317619-o7qfugjw 115 31 rapid rapid JJ cord-317619-o7qfugjw 115 32 turnaround turnaround NN cord-317619-o7qfugjw 115 33 time time NN cord-317619-o7qfugjw 115 34 ( ( -LRB- cord-317619-o7qfugjw 115 35 65 65 CD cord-317619-o7qfugjw 115 36 ) ) -RRB- cord-317619-o7qfugjw 115 37 . . . cord-317619-o7qfugjw 116 1 Since since IN cord-317619-o7qfugjw 116 2 clinical clinical JJ cord-317619-o7qfugjw 116 3 symptoms symptom NNS cord-317619-o7qfugjw 116 4 for for IN cord-317619-o7qfugjw 116 5 different different JJ cord-317619-o7qfugjw 116 6 viral viral JJ cord-317619-o7qfugjw 116 7 respiratory respiratory JJ cord-317619-o7qfugjw 116 8 infections infection NNS cord-317619-o7qfugjw 116 9 are be VBP cord-317619-o7qfugjw 116 10 often often RB cord-317619-o7qfugjw 116 11 the the DT cord-317619-o7qfugjw 116 12 same same JJ cord-317619-o7qfugjw 116 13 , , , cord-317619-o7qfugjw 116 14 and and CC cord-317619-o7qfugjw 116 15 with with IN cord-317619-o7qfugjw 116 16 the the DT cord-317619-o7qfugjw 116 17 limitations limitation NNS cord-317619-o7qfugjw 116 18 of of IN cord-317619-o7qfugjw 116 19 our -PRON- PRP$ cord-317619-o7qfugjw 116 20 current current JJ cord-317619-o7qfugjw 116 21 testing testing NN cord-317619-o7qfugjw 116 22 methods method NNS cord-317619-o7qfugjw 116 23 , , , cord-317619-o7qfugjw 116 24 it -PRON- PRP cord-317619-o7qfugjw 116 25 is be VBZ cord-317619-o7qfugjw 116 26 critical critical JJ cord-317619-o7qfugjw 116 27 that that IN cord-317619-o7qfugjw 116 28 clinicians clinician NNS cord-317619-o7qfugjw 116 29 obtain obtain VBP cord-317619-o7qfugjw 116 30 microbiology microbiology NN cord-317619-o7qfugjw 116 31 data datum NNS cord-317619-o7qfugjw 116 32 early early RB cord-317619-o7qfugjw 116 33 , , , cord-317619-o7qfugjw 116 34 especially especially RB cord-317619-o7qfugjw 116 35 in in IN cord-317619-o7qfugjw 116 36 the the DT cord-317619-o7qfugjw 116 37 risk risk NN cord-317619-o7qfugjw 116 38 population population NN cord-317619-o7qfugjw 116 39 ( ( -LRB- cord-317619-o7qfugjw 116 40 66 66 CD cord-317619-o7qfugjw 116 41 ) ) -RRB- cord-317619-o7qfugjw 117 1 ( ( -LRB- cord-317619-o7qfugjw 117 2 67 67 CD cord-317619-o7qfugjw 117 3 ) ) -RRB- cord-317619-o7qfugjw 118 1 ( ( -LRB- cord-317619-o7qfugjw 118 2 68 68 CD cord-317619-o7qfugjw 118 3 ) ) -RRB- cord-317619-o7qfugjw 118 4 ( ( -LRB- cord-317619-o7qfugjw 118 5 69 69 CD cord-317619-o7qfugjw 118 6 ) ) -RRB- cord-317619-o7qfugjw 118 7 . . . cord-317619-o7qfugjw 119 1 There there EX cord-317619-o7qfugjw 119 2 is be VBZ cord-317619-o7qfugjw 119 3 also also RB cord-317619-o7qfugjw 119 4 a a DT cord-317619-o7qfugjw 119 5 large large JJ cord-317619-o7qfugjw 119 6 variability variability NN cord-317619-o7qfugjw 119 7 of of IN cord-317619-o7qfugjw 119 8 disease disease NN cord-317619-o7qfugjw 119 9 severity severity NN cord-317619-o7qfugjw 119 10 in in IN cord-317619-o7qfugjw 119 11 children child NNS cord-317619-o7qfugjw 119 12 infected infect VBN cord-317619-o7qfugjw 119 13 with with IN cord-317619-o7qfugjw 119 14 RSV RSV NNP cord-317619-o7qfugjw 119 15 or or CC cord-317619-o7qfugjw 119 16 influenza influenza NN cord-317619-o7qfugjw 119 17 A a NN cord-317619-o7qfugjw 119 18 ( ( -LRB- cord-317619-o7qfugjw 119 19 H1N1 H1N1 NNP cord-317619-o7qfugjw 119 20 ) ) -RRB- cord-317619-o7qfugjw 119 21 virus virus NN cord-317619-o7qfugjw 119 22 . . . cord-317619-o7qfugjw 120 1 In in IN cord-317619-o7qfugjw 120 2 RSV RSV NNP cord-317619-o7qfugjw 120 3 infection infection NN cord-317619-o7qfugjw 120 4 , , , cord-317619-o7qfugjw 120 5 development development NN cord-317619-o7qfugjw 120 6 of of IN cord-317619-o7qfugjw 120 7 lower low JJR cord-317619-o7qfugjw 120 8 respiratory respiratory JJ cord-317619-o7qfugjw 120 9 track track NN cord-317619-o7qfugjw 120 10 disease disease NN cord-317619-o7qfugjw 120 11 in in IN cord-317619-o7qfugjw 120 12 premature premature JJ cord-317619-o7qfugjw 120 13 infants infant NNS cord-317619-o7qfugjw 120 14 , , , cord-317619-o7qfugjw 120 15 with with IN cord-317619-o7qfugjw 120 16 or or CC cord-317619-o7qfugjw 120 17 without without IN cord-317619-o7qfugjw 120 18 chronic chronic JJ cord-317619-o7qfugjw 120 19 neonatal neonatal JJ cord-317619-o7qfugjw 120 20 lung lung NN cord-317619-o7qfugjw 120 21 disease disease NN cord-317619-o7qfugjw 120 22 is be VBZ cord-317619-o7qfugjw 120 23 associated associate VBN cord-317619-o7qfugjw 120 24 with with IN cord-317619-o7qfugjw 120 25 a a DT cord-317619-o7qfugjw 120 26 significantly significantly RB cord-317619-o7qfugjw 120 27 higher high JJR cord-317619-o7qfugjw 120 28 risk risk NN cord-317619-o7qfugjw 120 29 of of IN cord-317619-o7qfugjw 120 30 hospitalization hospitalization NN cord-317619-o7qfugjw 120 31 , , , cord-317619-o7qfugjw 120 32 intensive intensive JJ cord-317619-o7qfugjw 120 33 care care NN cord-317619-o7qfugjw 120 34 unit unit NN cord-317619-o7qfugjw 120 35 admission admission NN cord-317619-o7qfugjw 120 36 , , , cord-317619-o7qfugjw 120 37 need need NN cord-317619-o7qfugjw 120 38 for for IN cord-317619-o7qfugjw 120 39 mechanical mechanical JJ cord-317619-o7qfugjw 120 40 ventilation ventilation NN cord-317619-o7qfugjw 120 41 , , , cord-317619-o7qfugjw 120 42 and and CC cord-317619-o7qfugjw 120 43 death death NN cord-317619-o7qfugjw 120 44 ( ( -LRB- cord-317619-o7qfugjw 120 45 12 12 CD cord-317619-o7qfugjw 120 46 , , , cord-317619-o7qfugjw 120 47 [ [ -LRB- cord-317619-o7qfugjw 120 48 70 70 CD cord-317619-o7qfugjw 120 49 ] ] -RRB- cord-317619-o7qfugjw 120 50 [ [ -LRB- cord-317619-o7qfugjw 120 51 71 71 CD cord-317619-o7qfugjw 120 52 ] ] -RRB- cord-317619-o7qfugjw 120 53 [ [ -LRB- cord-317619-o7qfugjw 120 54 72 72 CD cord-317619-o7qfugjw 120 55 ] ] -RRB- cord-317619-o7qfugjw 120 56 [ [ -LRB- cord-317619-o7qfugjw 120 57 73 73 CD cord-317619-o7qfugjw 120 58 ] ] -RRB- cord-317619-o7qfugjw 120 59 . . . cord-317619-o7qfugjw 121 1 In in IN cord-317619-o7qfugjw 121 2 a a DT cord-317619-o7qfugjw 121 3 study study NN cord-317619-o7qfugjw 121 4 of of IN cord-317619-o7qfugjw 121 5 2,147 2,147 CD cord-317619-o7qfugjw 121 6 children child NNS cord-317619-o7qfugjw 121 7 with with IN cord-317619-o7qfugjw 121 8 lower low JJR cord-317619-o7qfugjw 121 9 respiratory respiratory JJ cord-317619-o7qfugjw 121 10 infection infection NN cord-317619-o7qfugjw 121 11 due due JJ cord-317619-o7qfugjw 121 12 to to IN cord-317619-o7qfugjw 121 13 RSV RSV NNP cord-317619-o7qfugjw 121 14 , , , cord-317619-o7qfugjw 121 15 Rodriguez Rodriguez NNP cord-317619-o7qfugjw 121 16 et et NNP cord-317619-o7qfugjw 121 17 al al NNP cord-317619-o7qfugjw 121 18 . . . cord-317619-o7qfugjw 122 1 reported report VBN cord-317619-o7qfugjw 122 2 age age NN cord-317619-o7qfugjw 122 3 less less JJR cord-317619-o7qfugjw 122 4 than than IN cord-317619-o7qfugjw 122 5 6 6 CD cord-317619-o7qfugjw 122 6 months month NNS cord-317619-o7qfugjw 122 7 , , , cord-317619-o7qfugjw 122 8 history history NN cord-317619-o7qfugjw 122 9 of of IN cord-317619-o7qfugjw 122 10 prematurity prematurity NN cord-317619-o7qfugjw 122 11 , , , cord-317619-o7qfugjw 122 12 chronic chronic JJ cord-317619-o7qfugjw 122 13 respiratory respiratory JJ cord-317619-o7qfugjw 122 14 disease disease NN cord-317619-o7qfugjw 122 15 or or CC cord-317619-o7qfugjw 122 16 congenital congenital JJ cord-317619-o7qfugjw 122 17 heart heart NN cord-317619-o7qfugjw 122 18 disease disease NN cord-317619-o7qfugjw 122 19 , , , cord-317619-o7qfugjw 122 20 and and CC cord-317619-o7qfugjw 122 21 coinfection coinfection NN cord-317619-o7qfugjw 122 22 with with IN cord-317619-o7qfugjw 122 23 adenovirus adenovirus NN cord-317619-o7qfugjw 122 24 were be VBD cord-317619-o7qfugjw 122 25 significant significant JJ cord-317619-o7qfugjw 122 26 predictors predictor NNS cord-317619-o7qfugjw 122 27 of of IN cord-317619-o7qfugjw 122 28 increased increase VBN cord-317619-o7qfugjw 122 29 disease disease NN cord-317619-o7qfugjw 122 30 severity severity NN cord-317619-o7qfugjw 122 31 ( ( -LRB- cord-317619-o7qfugjw 122 32 74 74 CD cord-317619-o7qfugjw 122 33 ) ) -RRB- cord-317619-o7qfugjw 122 34 . . . cord-317619-o7qfugjw 123 1 Similar similar JJ cord-317619-o7qfugjw 123 2 predictors predictor NNS cord-317619-o7qfugjw 123 3 exist exist VBP cord-317619-o7qfugjw 123 4 for for IN cord-317619-o7qfugjw 123 5 children child NNS cord-317619-o7qfugjw 123 6 infected infect VBN cord-317619-o7qfugjw 123 7 with with IN cord-317619-o7qfugjw 123 8 influenza influenza NN cord-317619-o7qfugjw 123 9 A a NN cord-317619-o7qfugjw 123 10 ( ( -LRB- cord-317619-o7qfugjw 123 11 H1N1 H1N1 NNP cord-317619-o7qfugjw 123 12 ) ) -RRB- cord-317619-o7qfugjw 123 13 virus virus NN cord-317619-o7qfugjw 123 14 , , , cord-317619-o7qfugjw 123 15 including include VBG cord-317619-o7qfugjw 123 16 age age NN cord-317619-o7qfugjw 123 17 less less JJR cord-317619-o7qfugjw 123 18 than than IN cord-317619-o7qfugjw 123 19 5 5 CD cord-317619-o7qfugjw 123 20 years year NNS cord-317619-o7qfugjw 123 21 , , , cord-317619-o7qfugjw 123 22 a a DT cord-317619-o7qfugjw 123 23 history history NN cord-317619-o7qfugjw 123 24 of of IN cord-317619-o7qfugjw 123 25 chronic chronic JJ cord-317619-o7qfugjw 123 26 lung lung NN cord-317619-o7qfugjw 123 27 disease disease NN cord-317619-o7qfugjw 123 28 , , , cord-317619-o7qfugjw 123 29 congenital congenital JJ cord-317619-o7qfugjw 123 30 heart heart NN cord-317619-o7qfugjw 123 31 disease disease NN cord-317619-o7qfugjw 123 32 , , , cord-317619-o7qfugjw 123 33 and and CC cord-317619-o7qfugjw 123 34 immune immune JJ cord-317619-o7qfugjw 123 35 compromise compromise NN cord-317619-o7qfugjw 123 36 ( ( -LRB- cord-317619-o7qfugjw 123 37 Table table NN cord-317619-o7qfugjw 123 38 1 1 CD cord-317619-o7qfugjw 123 39 ) ) -RRB- cord-317619-o7qfugjw 123 40 ( ( -LRB- cord-317619-o7qfugjw 123 41 75 75 CD cord-317619-o7qfugjw 123 42 ) ) -RRB- cord-317619-o7qfugjw 123 43 . . . cord-317619-o7qfugjw 124 1 It -PRON- PRP cord-317619-o7qfugjw 124 2 is be VBZ cord-317619-o7qfugjw 124 3 therefore therefore RB cord-317619-o7qfugjw 124 4 prudent prudent JJ cord-317619-o7qfugjw 124 5 that that IN cord-317619-o7qfugjw 124 6 clinicians clinician NNS cord-317619-o7qfugjw 124 7 should should MD cord-317619-o7qfugjw 124 8 conduct conduct VB cord-317619-o7qfugjw 124 9 laboratory laboratory NN cord-317619-o7qfugjw 124 10 evaluations evaluation NNS cord-317619-o7qfugjw 124 11 early early RB cord-317619-o7qfugjw 124 12 in in IN cord-317619-o7qfugjw 124 13 the the DT cord-317619-o7qfugjw 124 14 illness illness NN cord-317619-o7qfugjw 124 15 for for IN cord-317619-o7qfugjw 124 16 viral viral JJ cord-317619-o7qfugjw 124 17 infections infection NNS cord-317619-o7qfugjw 124 18 in in IN cord-317619-o7qfugjw 124 19 these these DT cord-317619-o7qfugjw 124 20 at at IN cord-317619-o7qfugjw 124 21 - - HYPH cord-317619-o7qfugjw 124 22 risk risk NN cord-317619-o7qfugjw 124 23 populations population NNS cord-317619-o7qfugjw 124 24 presenting present VBG cord-317619-o7qfugjw 124 25 with with IN cord-317619-o7qfugjw 124 26 respiratory respiratory JJ cord-317619-o7qfugjw 124 27 failure failure NN cord-317619-o7qfugjw 124 28 and and CC cord-317619-o7qfugjw 124 29 ARDS ARDS NNP cord-317619-o7qfugjw 124 30 . . . cord-317619-o7qfugjw 125 1 In in IN cord-317619-o7qfugjw 125 2 contrast contrast NN cord-317619-o7qfugjw 125 3 to to IN cord-317619-o7qfugjw 125 4 clinical clinical JJ cord-317619-o7qfugjw 125 5 predictors predictor NNS cord-317619-o7qfugjw 125 6 of of IN cord-317619-o7qfugjw 125 7 disease disease NN cord-317619-o7qfugjw 125 8 severity severity NN cord-317619-o7qfugjw 125 9 , , , cord-317619-o7qfugjw 125 10 the the DT cord-317619-o7qfugjw 125 11 contribution contribution NN cord-317619-o7qfugjw 125 12 of of IN cord-317619-o7qfugjw 125 13 viral viral JJ cord-317619-o7qfugjw 125 14 factors factor NNS cord-317619-o7qfugjw 125 15 to to IN cord-317619-o7qfugjw 125 16 disease disease NN cord-317619-o7qfugjw 125 17 burden burden NN cord-317619-o7qfugjw 125 18 remains remain VBZ cord-317619-o7qfugjw 125 19 unclear unclear JJ cord-317619-o7qfugjw 125 20 . . . cord-317619-o7qfugjw 126 1 In in IN cord-317619-o7qfugjw 126 2 RSV RSV NNP cord-317619-o7qfugjw 126 3 infection infection NN cord-317619-o7qfugjw 126 4 , , , cord-317619-o7qfugjw 126 5 although although IN cord-317619-o7qfugjw 126 6 earlier early JJR cord-317619-o7qfugjw 126 7 studies study NNS cord-317619-o7qfugjw 126 8 suggested suggest VBD cord-317619-o7qfugjw 126 9 no no DT cord-317619-o7qfugjw 126 10 correlation correlation NN cord-317619-o7qfugjw 126 11 between between IN cord-317619-o7qfugjw 126 12 viral viral JJ cord-317619-o7qfugjw 126 13 load load NN cord-317619-o7qfugjw 126 14 and and CC cord-317619-o7qfugjw 126 15 disease disease NN cord-317619-o7qfugjw 126 16 severity severity NN cord-317619-o7qfugjw 126 17 ( ( -LRB- cord-317619-o7qfugjw 126 18 76 76 CD cord-317619-o7qfugjw 126 19 , , , cord-317619-o7qfugjw 126 20 77 77 CD cord-317619-o7qfugjw 126 21 ) ) -RRB- cord-317619-o7qfugjw 127 1 newer new JJR cord-317619-o7qfugjw 127 2 findings finding NNS cord-317619-o7qfugjw 127 3 suggest suggest VBP cord-317619-o7qfugjw 127 4 otherwise otherwise RB cord-317619-o7qfugjw 127 5 . . . cord-317619-o7qfugjw 128 1 Studies study NNS cord-317619-o7qfugjw 128 2 by by IN cord-317619-o7qfugjw 128 3 both both DT cord-317619-o7qfugjw 128 4 DeVincenzo DeVincenzo NNP cord-317619-o7qfugjw 128 5 et et NNP cord-317619-o7qfugjw 128 6 al al NNP cord-317619-o7qfugjw 128 7 . . . cord-317619-o7qfugjw 129 1 and and CC cord-317619-o7qfugjw 129 2 Houben Houben NNP cord-317619-o7qfugjw 129 3 et et NNP cord-317619-o7qfugjw 129 4 al al NNP cord-317619-o7qfugjw 129 5 . . NNP cord-317619-o7qfugjw 129 6 reported report VBD cord-317619-o7qfugjw 129 7 a a DT cord-317619-o7qfugjw 129 8 direct direct JJ cord-317619-o7qfugjw 129 9 correlation correlation NN cord-317619-o7qfugjw 129 10 between between IN cord-317619-o7qfugjw 129 11 viral viral JJ cord-317619-o7qfugjw 129 12 load load NN cord-317619-o7qfugjw 129 13 and and CC cord-317619-o7qfugjw 129 14 disease disease NN cord-317619-o7qfugjw 129 15 severity severity NN cord-317619-o7qfugjw 129 16 in in IN cord-317619-o7qfugjw 129 17 infants infant NNS cord-317619-o7qfugjw 129 18 with with IN cord-317619-o7qfugjw 129 19 primary primary JJ cord-317619-o7qfugjw 129 20 RSV RSV NNP cord-317619-o7qfugjw 129 21 infection infection NN cord-317619-o7qfugjw 129 22 ( ( -LRB- cord-317619-o7qfugjw 129 23 78 78 CD cord-317619-o7qfugjw 129 24 , , , cord-317619-o7qfugjw 129 25 79 79 CD cord-317619-o7qfugjw 129 26 ) ) -RRB- cord-317619-o7qfugjw 129 27 . . . cord-317619-o7qfugjw 130 1 El El NNP cord-317619-o7qfugjw 130 2 Saleeby Saleeby NNP cord-317619-o7qfugjw 130 3 et et NNP cord-317619-o7qfugjw 130 4 al al NNP cord-317619-o7qfugjw 130 5 . . . cord-317619-o7qfugjw 131 1 also also RB cord-317619-o7qfugjw 131 2 reported report VBD cord-317619-o7qfugjw 131 3 that that IN cord-317619-o7qfugjw 131 4 viral viral JJ cord-317619-o7qfugjw 131 5 load load NN cord-317619-o7qfugjw 131 6 is be VBZ cord-317619-o7qfugjw 131 7 independently independently RB cord-317619-o7qfugjw 131 8 associated associate VBN cord-317619-o7qfugjw 131 9 with with IN cord-317619-o7qfugjw 131 10 increased increase VBN cord-317619-o7qfugjw 131 11 risk risk NN cord-317619-o7qfugjw 131 12 of of IN cord-317619-o7qfugjw 131 13 patients patient NNS cord-317619-o7qfugjw 131 14 with with IN cord-317619-o7qfugjw 131 15 RSV RSV NNP cord-317619-o7qfugjw 131 16 requiring require VBG cord-317619-o7qfugjw 131 17 prolonged prolong VBN cord-317619-o7qfugjw 131 18 hospitalization hospitalization NN cord-317619-o7qfugjw 131 19 or or CC cord-317619-o7qfugjw 131 20 intensive intensive JJ cord-317619-o7qfugjw 131 21 care care NN cord-317619-o7qfugjw 131 22 , , , cord-317619-o7qfugjw 131 23 or or CC cord-317619-o7qfugjw 131 24 to to TO cord-317619-o7qfugjw 131 25 develop develop VB cord-317619-o7qfugjw 131 26 respiratory respiratory JJ cord-317619-o7qfugjw 131 27 failure failure NN cord-317619-o7qfugjw 131 28 ( ( -LRB- cord-317619-o7qfugjw 131 29 80 80 CD cord-317619-o7qfugjw 131 30 ) ) -RRB- cord-317619-o7qfugjw 131 31 . . . cord-317619-o7qfugjw 132 1 The the DT cord-317619-o7qfugjw 132 2 relevance relevance NN cord-317619-o7qfugjw 132 3 of of IN cord-317619-o7qfugjw 132 4 viral viral JJ cord-317619-o7qfugjw 132 5 load load NN cord-317619-o7qfugjw 132 6 in in IN cord-317619-o7qfugjw 132 7 influenza influenza NN cord-317619-o7qfugjw 132 8 A a NN cord-317619-o7qfugjw 132 9 ( ( -LRB- cord-317619-o7qfugjw 132 10 H1N1 H1N1 NNP cord-317619-o7qfugjw 132 11 ) ) -RRB- cord-317619-o7qfugjw 132 12 virus virus NN cord-317619-o7qfugjw 132 13 infection infection NN cord-317619-o7qfugjw 132 14 is be VBZ cord-317619-o7qfugjw 132 15 unclear unclear JJ cord-317619-o7qfugjw 132 16 . . . cord-317619-o7qfugjw 133 1 Launes Launes NNP cord-317619-o7qfugjw 133 2 et et NNP cord-317619-o7qfugjw 133 3 al al NNP cord-317619-o7qfugjw 133 4 . . . cord-317619-o7qfugjw 134 1 found find VBD cord-317619-o7qfugjw 134 2 that that IN cord-317619-o7qfugjw 134 3 in in IN cord-317619-o7qfugjw 134 4 children child NNS cord-317619-o7qfugjw 134 5 who who WP cord-317619-o7qfugjw 134 6 had have VBD cord-317619-o7qfugjw 134 7 more more JJR cord-317619-o7qfugjw 134 8 than than IN cord-317619-o7qfugjw 134 9 5 5 CD cord-317619-o7qfugjw 134 10 days day NNS cord-317619-o7qfugjw 134 11 of of IN cord-317619-o7qfugjw 134 12 symptoms symptom NNS cord-317619-o7qfugjw 134 13 , , , cord-317619-o7qfugjw 134 14 a a DT cord-317619-o7qfugjw 134 15 higher high JJR cord-317619-o7qfugjw 134 16 influenza influenza NN cord-317619-o7qfugjw 134 17 A a NN cord-317619-o7qfugjw 134 18 ( ( -LRB- cord-317619-o7qfugjw 134 19 H1N1 H1N1 NNP cord-317619-o7qfugjw 134 20 ) ) -RRB- cord-317619-o7qfugjw 134 21 viral viral JJ cord-317619-o7qfugjw 134 22 load load NN cord-317619-o7qfugjw 134 23 at at IN cord-317619-o7qfugjw 134 24 diagnosis diagnosis NN cord-317619-o7qfugjw 134 25 correlated correlate VBN cord-317619-o7qfugjw 134 26 with with IN cord-317619-o7qfugjw 134 27 an an DT cord-317619-o7qfugjw 134 28 increased increase VBN cord-317619-o7qfugjw 134 29 risk risk NN cord-317619-o7qfugjw 134 30 of of IN cord-317619-o7qfugjw 134 31 requiring require VBG cord-317619-o7qfugjw 134 32 mechanical mechanical JJ cord-317619-o7qfugjw 134 33 ventilation ventilation NN cord-317619-o7qfugjw 134 34 ( ( -LRB- cord-317619-o7qfugjw 134 35 81 81 CD cord-317619-o7qfugjw 134 36 ) ) -RRB- cord-317619-o7qfugjw 134 37 . . . cord-317619-o7qfugjw 135 1 Similarly similarly RB cord-317619-o7qfugjw 135 2 others other NNS cord-317619-o7qfugjw 135 3 have have VBP cord-317619-o7qfugjw 135 4 found find VBN cord-317619-o7qfugjw 135 5 that that IN cord-317619-o7qfugjw 135 6 patients patient NNS cord-317619-o7qfugjw 135 7 with with IN cord-317619-o7qfugjw 135 8 systemic systemic JJ cord-317619-o7qfugjw 135 9 symptoms symptom NNS cord-317619-o7qfugjw 135 10 and and CC cord-317619-o7qfugjw 135 11 pneumonia pneumonia NN cord-317619-o7qfugjw 135 12 had have VBD cord-317619-o7qfugjw 135 13 higher high JJR cord-317619-o7qfugjw 135 14 viral viral JJ cord-317619-o7qfugjw 135 15 load load NN cord-317619-o7qfugjw 135 16 when when WRB cord-317619-o7qfugjw 135 17 compared compare VBN cord-317619-o7qfugjw 135 18 to to IN cord-317619-o7qfugjw 135 19 those those DT cord-317619-o7qfugjw 135 20 with with IN cord-317619-o7qfugjw 135 21 uncomplicated uncomplicated JJ cord-317619-o7qfugjw 135 22 upper upper JJ cord-317619-o7qfugjw 135 23 respiratory respiratory JJ cord-317619-o7qfugjw 135 24 tract tract NN cord-317619-o7qfugjw 135 25 infections infection NNS cord-317619-o7qfugjw 135 26 alone alone JJ cord-317619-o7qfugjw 135 27 ( ( -LRB- cord-317619-o7qfugjw 135 28 82 82 CD cord-317619-o7qfugjw 135 29 ) ) -RRB- cord-317619-o7qfugjw 135 30 . . . cord-317619-o7qfugjw 136 1 As as IN cord-317619-o7qfugjw 136 2 would would MD cord-317619-o7qfugjw 136 3 be be VB cord-317619-o7qfugjw 136 4 expected expect VBN cord-317619-o7qfugjw 136 5 children child NNS cord-317619-o7qfugjw 136 6 have have VB cord-317619-o7qfugjw 136 7 a a DT cord-317619-o7qfugjw 136 8 higher high JJR cord-317619-o7qfugjw 136 9 influenza influenza NN cord-317619-o7qfugjw 136 10 A a NN cord-317619-o7qfugjw 136 11 ( ( -LRB- cord-317619-o7qfugjw 136 12 H1N1 H1N1 NNP cord-317619-o7qfugjw 136 13 ) ) -RRB- cord-317619-o7qfugjw 136 14 viral viral JJ cord-317619-o7qfugjw 136 15 load load NN cord-317619-o7qfugjw 136 16 compared compare VBN cord-317619-o7qfugjw 136 17 to to IN cord-317619-o7qfugjw 136 18 adults adult NNS cord-317619-o7qfugjw 136 19 because because IN cord-317619-o7qfugjw 136 20 of of IN cord-317619-o7qfugjw 136 21 less less JJR cord-317619-o7qfugjw 136 22 exposure exposure NN cord-317619-o7qfugjw 136 23 to to IN cord-317619-o7qfugjw 136 24 influenza influenza NN cord-317619-o7qfugjw 136 25 antigens antigen NNS cord-317619-o7qfugjw 136 26 . . . cord-317619-o7qfugjw 137 1 However however RB cord-317619-o7qfugjw 137 2 , , , cord-317619-o7qfugjw 137 3 this this DT cord-317619-o7qfugjw 137 4 finding finding NN cord-317619-o7qfugjw 137 5 did do VBD cord-317619-o7qfugjw 137 6 not not RB cord-317619-o7qfugjw 137 7 correlate correlate VB cord-317619-o7qfugjw 137 8 with with IN cord-317619-o7qfugjw 137 9 the the DT cord-317619-o7qfugjw 137 10 occurrence occurrence NN cord-317619-o7qfugjw 137 11 of of IN cord-317619-o7qfugjw 137 12 disease disease NN cord-317619-o7qfugjw 137 13 complications complication NNS cord-317619-o7qfugjw 137 14 ( ( -LRB- cord-317619-o7qfugjw 137 15 83 83 CD cord-317619-o7qfugjw 137 16 ) ) -RRB- cord-317619-o7qfugjw 137 17 . . . cord-317619-o7qfugjw 138 1 Both both DT cord-317619-o7qfugjw 138 2 RSV RSV NNP cord-317619-o7qfugjw 138 3 and and CC cord-317619-o7qfugjw 138 4 influenza influenza NN cord-317619-o7qfugjw 138 5 A a NN cord-317619-o7qfugjw 138 6 ( ( -LRB- cord-317619-o7qfugjw 138 7 H1N1 H1N1 NNP cord-317619-o7qfugjw 138 8 ) ) -RRB- cord-317619-o7qfugjw 138 9 virus virus NN cord-317619-o7qfugjw 138 10 result result VBP cord-317619-o7qfugjw 138 11 in in IN cord-317619-o7qfugjw 138 12 a a DT cord-317619-o7qfugjw 138 13 broad broad JJ cord-317619-o7qfugjw 138 14 spectrum spectrum NN cord-317619-o7qfugjw 138 15 of of IN cord-317619-o7qfugjw 138 16 disease disease NN cord-317619-o7qfugjw 138 17 , , , cord-317619-o7qfugjw 138 18 ranging range VBG cord-317619-o7qfugjw 138 19 from from IN cord-317619-o7qfugjw 138 20 mild mild JJ cord-317619-o7qfugjw 138 21 upper upper JJ cord-317619-o7qfugjw 138 22 respiratory respiratory JJ cord-317619-o7qfugjw 138 23 symptoms symptom NNS cord-317619-o7qfugjw 138 24 to to TO cord-317619-o7qfugjw 138 25 fulminant fulminant JJ cord-317619-o7qfugjw 138 26 respiratory respiratory JJ cord-317619-o7qfugjw 138 27 failure failure NN cord-317619-o7qfugjw 138 28 and and CC cord-317619-o7qfugjw 138 29 ARDS ARDS NNP cord-317619-o7qfugjw 138 30 ( ( -LRB- cord-317619-o7qfugjw 138 31 59 59 CD cord-317619-o7qfugjw 138 32 , , , cord-317619-o7qfugjw 138 33 84 84 CD cord-317619-o7qfugjw 138 34 ) ) -RRB- cord-317619-o7qfugjw 138 35 . . . cord-317619-o7qfugjw 139 1 This this DT cord-317619-o7qfugjw 139 2 high high JJ cord-317619-o7qfugjw 139 3 degree degree NN cord-317619-o7qfugjw 139 4 of of IN cord-317619-o7qfugjw 139 5 variability variability NN cord-317619-o7qfugjw 139 6 may may MD cord-317619-o7qfugjw 139 7 be be VB cord-317619-o7qfugjw 139 8 due due JJ cord-317619-o7qfugjw 139 9 to to IN cord-317619-o7qfugjw 139 10 the the DT cord-317619-o7qfugjw 139 11 pathogenicity pathogenicity NN cord-317619-o7qfugjw 139 12 of of IN cord-317619-o7qfugjw 139 13 the the DT cord-317619-o7qfugjw 139 14 viral viral JJ cord-317619-o7qfugjw 139 15 pathogen pathogen NN cord-317619-o7qfugjw 139 16 , , , cord-317619-o7qfugjw 139 17 host host NN cord-317619-o7qfugjw 139 18 immune immune JJ cord-317619-o7qfugjw 139 19 response response NN cord-317619-o7qfugjw 139 20 , , , cord-317619-o7qfugjw 139 21 or or CC cord-317619-o7qfugjw 139 22 a a DT cord-317619-o7qfugjw 139 23 combination combination NN cord-317619-o7qfugjw 139 24 of of IN cord-317619-o7qfugjw 139 25 both both DT cord-317619-o7qfugjw 139 26 ( ( -LRB- cord-317619-o7qfugjw 139 27 85 85 CD cord-317619-o7qfugjw 139 28 ) ) -RRB- cord-317619-o7qfugjw 139 29 . . . cord-317619-o7qfugjw 140 1 Human human JJ cord-317619-o7qfugjw 140 2 RSV RSV NNP cord-317619-o7qfugjw 140 3 consists consist VBZ cord-317619-o7qfugjw 140 4 of of IN cord-317619-o7qfugjw 140 5 subgroups subgroup NNS cord-317619-o7qfugjw 140 6 A A NNP cord-317619-o7qfugjw 140 7 and and CC cord-317619-o7qfugjw 140 8 B b NN cord-317619-o7qfugjw 140 9 and and CC cord-317619-o7qfugjw 140 10 primarily primarily RB cord-317619-o7qfugjw 140 11 infects infect VBZ cord-317619-o7qfugjw 140 12 humans human NNS cord-317619-o7qfugjw 140 13 . . . cord-317619-o7qfugjw 141 1 The the DT cord-317619-o7qfugjw 141 2 RSV RSV NNP cord-317619-o7qfugjw 141 3 genome genome NN cord-317619-o7qfugjw 141 4 encodes encode VBZ cord-317619-o7qfugjw 141 5 11 11 CD cord-317619-o7qfugjw 141 6 different different JJ cord-317619-o7qfugjw 141 7 proteins protein NNS cord-317619-o7qfugjw 141 8 involved involve VBN cord-317619-o7qfugjw 141 9 in in IN cord-317619-o7qfugjw 141 10 transmission transmission NN cord-317619-o7qfugjw 141 11 , , , cord-317619-o7qfugjw 141 12 infection infection NN cord-317619-o7qfugjw 141 13 , , , cord-317619-o7qfugjw 141 14 evasion evasion NN cord-317619-o7qfugjw 141 15 of of IN cord-317619-o7qfugjw 141 16 host host NN cord-317619-o7qfugjw 141 17 response response NN cord-317619-o7qfugjw 141 18 , , , cord-317619-o7qfugjw 141 19 and and CC cord-317619-o7qfugjw 141 20 replication replication NN cord-317619-o7qfugjw 141 21 ( ( -LRB- cord-317619-o7qfugjw 141 22 86 86 CD cord-317619-o7qfugjw 141 23 ) ) -RRB- cord-317619-o7qfugjw 141 24 . . . cord-317619-o7qfugjw 142 1 Infection infection NN cord-317619-o7qfugjw 142 2 is be VBZ cord-317619-o7qfugjw 142 3 typically typically RB cord-317619-o7qfugjw 142 4 restricted restrict VBN cord-317619-o7qfugjw 142 5 to to IN cord-317619-o7qfugjw 142 6 respiratory respiratory JJ cord-317619-o7qfugjw 142 7 epithelial epithelial JJ cord-317619-o7qfugjw 142 8 cells cell NNS cord-317619-o7qfugjw 142 9 , , , cord-317619-o7qfugjw 142 10 including include VBG cord-317619-o7qfugjw 142 11 both both DT cord-317619-o7qfugjw 142 12 type type NN cord-317619-o7qfugjw 142 13 I -PRON- PRP cord-317619-o7qfugjw 142 14 and and CC cord-317619-o7qfugjw 142 15 type type NN cord-317619-o7qfugjw 142 16 II ii CD cord-317619-o7qfugjw 142 17 alveolar alveolar NN cord-317619-o7qfugjw 142 18 pneumocytes pneumocyte NNS cord-317619-o7qfugjw 142 19 , , , cord-317619-o7qfugjw 142 20 from from IN cord-317619-o7qfugjw 142 21 the the DT cord-317619-o7qfugjw 142 22 trachea trachea NN cord-317619-o7qfugjw 142 23 to to IN cord-317619-o7qfugjw 142 24 the the DT cord-317619-o7qfugjw 142 25 level level NN cord-317619-o7qfugjw 142 26 of of IN cord-317619-o7qfugjw 142 27 bronchioles bronchiole NNS cord-317619-o7qfugjw 142 28 . . . cord-317619-o7qfugjw 143 1 Infection infection NN cord-317619-o7qfugjw 143 2 leads lead VBZ cord-317619-o7qfugjw 143 3 to to IN cord-317619-o7qfugjw 143 4 epithelial epithelial JJ cord-317619-o7qfugjw 143 5 and and CC cord-317619-o7qfugjw 143 6 interstitial interstitial JJ cord-317619-o7qfugjw 143 7 inflammation inflammation NN cord-317619-o7qfugjw 143 8 with with IN cord-317619-o7qfugjw 143 9 progression progression NN cord-317619-o7qfugjw 143 10 to to IN cord-317619-o7qfugjw 143 11 inflammatory inflammatory JJ cord-317619-o7qfugjw 143 12 infiltrates infiltrate NNS cord-317619-o7qfugjw 143 13 and and CC cord-317619-o7qfugjw 143 14 epithelial epithelial JJ cord-317619-o7qfugjw 143 15 sloughing slough VBG cord-317619-o7qfugjw 143 16 ( ( -LRB- cord-317619-o7qfugjw 143 17 87 87 CD cord-317619-o7qfugjw 143 18 ) ) -RRB- cord-317619-o7qfugjw 143 19 . . . cord-317619-o7qfugjw 144 1 After after IN cord-317619-o7qfugjw 144 2 infection infection NN cord-317619-o7qfugjw 144 3 and and CC cord-317619-o7qfugjw 144 4 viral viral JJ cord-317619-o7qfugjw 144 5 replication replication NN cord-317619-o7qfugjw 144 6 , , , cord-317619-o7qfugjw 144 7 RSV RSV NNP cord-317619-o7qfugjw 144 8 causes cause VBZ cord-317619-o7qfugjw 144 9 epithelial epithelial JJ cord-317619-o7qfugjw 144 10 cells cell NNS cord-317619-o7qfugjw 144 11 to to TO cord-317619-o7qfugjw 144 12 fuse fuse NN cord-317619-o7qfugjw 144 13 , , , cord-317619-o7qfugjw 144 14 forming form VBG cord-317619-o7qfugjw 144 15 a a DT cord-317619-o7qfugjw 144 16 syncytium syncytium NN cord-317619-o7qfugjw 144 17 from from IN cord-317619-o7qfugjw 144 18 which which WDT cord-317619-o7qfugjw 144 19 the the DT cord-317619-o7qfugjw 144 20 virus virus NN cord-317619-o7qfugjw 144 21 spreads spread VBZ cord-317619-o7qfugjw 144 22 from from IN cord-317619-o7qfugjw 144 23 cell cell NN cord-317619-o7qfugjw 144 24 to to IN cord-317619-o7qfugjw 144 25 cell cell NN cord-317619-o7qfugjw 144 26 ( ( -LRB- cord-317619-o7qfugjw 144 27 88 88 CD cord-317619-o7qfugjw 144 28 ) ) -RRB- cord-317619-o7qfugjw 144 29 . . . cord-317619-o7qfugjw 145 1 Those those DT cord-317619-o7qfugjw 145 2 infected infect VBN cord-317619-o7qfugjw 145 3 epithelial epithelial JJ cord-317619-o7qfugjw 145 4 cells cell NNS cord-317619-o7qfugjw 145 5 are be VBP cord-317619-o7qfugjw 145 6 then then RB cord-317619-o7qfugjw 145 7 destroyed destroy VBN cord-317619-o7qfugjw 145 8 , , , cord-317619-o7qfugjw 145 9 releasing release VBG cord-317619-o7qfugjw 145 10 inflammatory inflammatory JJ cord-317619-o7qfugjw 145 11 cytokines cytokine NNS cord-317619-o7qfugjw 145 12 and and CC cord-317619-o7qfugjw 145 13 chemokines chemokine NNS cord-317619-o7qfugjw 145 14 that that WDT cord-317619-o7qfugjw 145 15 ultimately ultimately RB cord-317619-o7qfugjw 145 16 attract attract VBP cord-317619-o7qfugjw 145 17 additional additional JJ cord-317619-o7qfugjw 145 18 inflammatory inflammatory JJ cord-317619-o7qfugjw 145 19 cells cell NNS cord-317619-o7qfugjw 145 20 and and CC cord-317619-o7qfugjw 145 21 degrade degrade VB cord-317619-o7qfugjw 145 22 capillary capillary JJ cord-317619-o7qfugjw 145 23 integrity integrity NN cord-317619-o7qfugjw 145 24 ( ( -LRB- cord-317619-o7qfugjw 145 25 89 89 CD cord-317619-o7qfugjw 145 26 ) ) -RRB- cord-317619-o7qfugjw 145 27 . . . cord-317619-o7qfugjw 146 1 Disruption disruption NN cord-317619-o7qfugjw 146 2 of of IN cord-317619-o7qfugjw 146 3 the the DT cord-317619-o7qfugjw 146 4 alveolar alveolar NN cord-317619-o7qfugjw 146 5 - - HYPH cord-317619-o7qfugjw 146 6 capillary capillary JJ cord-317619-o7qfugjw 146 7 barrier barrier NN cord-317619-o7qfugjw 146 8 results result NNS cord-317619-o7qfugjw 146 9 in in IN cord-317619-o7qfugjw 146 10 leakage leakage NN cord-317619-o7qfugjw 146 11 of of IN cord-317619-o7qfugjw 146 12 plasma plasma NN cord-317619-o7qfugjw 146 13 proteins protein NNS cord-317619-o7qfugjw 146 14 into into IN cord-317619-o7qfugjw 146 15 interstitial interstitial JJ cord-317619-o7qfugjw 146 16 tissue tissue NN cord-317619-o7qfugjw 146 17 and and CC cord-317619-o7qfugjw 146 18 within within IN cord-317619-o7qfugjw 146 19 the the DT cord-317619-o7qfugjw 146 20 alveoli alveolus NNS cord-317619-o7qfugjw 146 21 , , , cord-317619-o7qfugjw 146 22 finally finally RB cord-317619-o7qfugjw 146 23 interfering interfere VBG cord-317619-o7qfugjw 146 24 with with IN cord-317619-o7qfugjw 146 25 surfactant surfactant NN cord-317619-o7qfugjw 146 26 function function NN cord-317619-o7qfugjw 146 27 ( ( -LRB- cord-317619-o7qfugjw 146 28 90 90 CD cord-317619-o7qfugjw 146 29 ) ) -RRB- cord-317619-o7qfugjw 146 30 . . . cord-317619-o7qfugjw 147 1 With with IN cord-317619-o7qfugjw 147 2 an an DT cord-317619-o7qfugjw 147 3 understanding understanding NN cord-317619-o7qfugjw 147 4 of of IN cord-317619-o7qfugjw 147 5 the the DT cord-317619-o7qfugjw 147 6 pathophysiologic pathophysiologic JJ cord-317619-o7qfugjw 147 7 process process NN cord-317619-o7qfugjw 147 8 of of IN cord-317619-o7qfugjw 147 9 RSV RSV NNP cord-317619-o7qfugjw 147 10 , , , cord-317619-o7qfugjw 147 11 it -PRON- PRP cord-317619-o7qfugjw 147 12 is be VBZ cord-317619-o7qfugjw 147 13 no no DT cord-317619-o7qfugjw 147 14 surprise surprise NN cord-317619-o7qfugjw 147 15 that that IN cord-317619-o7qfugjw 147 16 progression progression NN cord-317619-o7qfugjw 147 17 to to IN cord-317619-o7qfugjw 147 18 ARDS ARDS NNP cord-317619-o7qfugjw 147 19 is be VBZ cord-317619-o7qfugjw 147 20 a a DT cord-317619-o7qfugjw 147 21 potential potential JJ cord-317619-o7qfugjw 147 22 end end NN cord-317619-o7qfugjw 147 23 point point NN cord-317619-o7qfugjw 147 24 . . . cord-317619-o7qfugjw 148 1 Aside aside RB cord-317619-o7qfugjw 148 2 from from IN cord-317619-o7qfugjw 148 3 viral viral JJ cord-317619-o7qfugjw 148 4 pathogenicity pathogenicity NN cord-317619-o7qfugjw 148 5 , , , cord-317619-o7qfugjw 148 6 host host NN cord-317619-o7qfugjw 148 7 immune immune NN cord-317619-o7qfugjw 148 8 - - HYPH cord-317619-o7qfugjw 148 9 mediated mediate VBN cord-317619-o7qfugjw 148 10 factors factor NNS cord-317619-o7qfugjw 148 11 also also RB cord-317619-o7qfugjw 148 12 contribute contribute VBP cord-317619-o7qfugjw 148 13 to to IN cord-317619-o7qfugjw 148 14 disease disease NN cord-317619-o7qfugjw 148 15 severity severity NN cord-317619-o7qfugjw 148 16 . . . cord-317619-o7qfugjw 149 1 A a DT cord-317619-o7qfugjw 149 2 rapidly rapidly RB cord-317619-o7qfugjw 149 3 progressive progressive JJ cord-317619-o7qfugjw 149 4 area area NN cord-317619-o7qfugjw 149 5 of of IN cord-317619-o7qfugjw 149 6 research research NN cord-317619-o7qfugjw 149 7 is be VBZ cord-317619-o7qfugjw 149 8 in in IN cord-317619-o7qfugjw 149 9 understanding understand VBG cord-317619-o7qfugjw 149 10 the the DT cord-317619-o7qfugjw 149 11 role role NN cord-317619-o7qfugjw 149 12 of of IN cord-317619-o7qfugjw 149 13 biomarkers biomarker NNS cord-317619-o7qfugjw 149 14 not not RB cord-317619-o7qfugjw 149 15 only only RB cord-317619-o7qfugjw 149 16 in in IN cord-317619-o7qfugjw 149 17 the the DT cord-317619-o7qfugjw 149 18 diagnosis diagnosis NN cord-317619-o7qfugjw 149 19 and and CC cord-317619-o7qfugjw 149 20 prognosis prognosis NN cord-317619-o7qfugjw 149 21 of of IN cord-317619-o7qfugjw 149 22 ARDS ARDS NNP cord-317619-o7qfugjw 149 23 , , , cord-317619-o7qfugjw 149 24 but but CC cord-317619-o7qfugjw 149 25 also also RB cord-317619-o7qfugjw 149 26 in in IN cord-317619-o7qfugjw 149 27 potential potential JJ cord-317619-o7qfugjw 149 28 therapeutic therapeutic JJ cord-317619-o7qfugjw 149 29 options option NNS cord-317619-o7qfugjw 149 30 to to TO cord-317619-o7qfugjw 149 31 alter alter VB cord-317619-o7qfugjw 149 32 such such JJ cord-317619-o7qfugjw 149 33 biomarkers biomarker NNS cord-317619-o7qfugjw 149 34 ( ( -LRB- cord-317619-o7qfugjw 149 35 91 91 CD cord-317619-o7qfugjw 149 36 ) ) -RRB- cord-317619-o7qfugjw 149 37 . . . cord-317619-o7qfugjw 150 1 Inflammatory inflammatory JJ cord-317619-o7qfugjw 150 2 proteins protein NNS cord-317619-o7qfugjw 150 3 in in IN cord-317619-o7qfugjw 150 4 the the DT cord-317619-o7qfugjw 150 5 matrix matrix NN cord-317619-o7qfugjw 150 6 metalloproteinase metalloproteinase NN cord-317619-o7qfugjw 150 7 ( ( -LRB- cord-317619-o7qfugjw 150 8 MMP MMP NNP cord-317619-o7qfugjw 150 9 ) ) -RRB- cord-317619-o7qfugjw 150 10 family family NN cord-317619-o7qfugjw 150 11 have have VBP cord-317619-o7qfugjw 150 12 been be VBN cord-317619-o7qfugjw 150 13 shown show VBN cord-317619-o7qfugjw 150 14 to to TO cord-317619-o7qfugjw 150 15 be be VB cord-317619-o7qfugjw 150 16 elevated elevate VBN cord-317619-o7qfugjw 150 17 in in IN cord-317619-o7qfugjw 150 18 pediatric pediatric JJ cord-317619-o7qfugjw 150 19 ALI ALI NNP cord-317619-o7qfugjw 150 20 ( ( -LRB- cord-317619-o7qfugjw 150 21 92 92 CD cord-317619-o7qfugjw 150 22 ) ) -RRB- cord-317619-o7qfugjw 150 23 with with IN cord-317619-o7qfugjw 150 24 a a DT cord-317619-o7qfugjw 150 25 specific specific JJ cord-317619-o7qfugjw 150 26 increase increase NN cord-317619-o7qfugjw 150 27 in in IN cord-317619-o7qfugjw 150 28 MMP-9 MMP-9 NNP cord-317619-o7qfugjw 150 29 production production NN cord-317619-o7qfugjw 150 30 in in IN cord-317619-o7qfugjw 150 31 RSV RSV NNP cord-317619-o7qfugjw 150 32 infection infection NN cord-317619-o7qfugjw 150 33 . . . cord-317619-o7qfugjw 151 1 Blocking block VBG cord-317619-o7qfugjw 151 2 MMP-9 MMP-9 NNP cord-317619-o7qfugjw 151 3 in in IN cord-317619-o7qfugjw 151 4 vitro vitro FW cord-317619-o7qfugjw 151 5 and and CC cord-317619-o7qfugjw 151 6 in in IN cord-317619-o7qfugjw 151 7 vivo vivo NNP cord-317619-o7qfugjw 151 8 resulted result VBD cord-317619-o7qfugjw 151 9 in in IN cord-317619-o7qfugjw 151 10 decrease decrease NN cord-317619-o7qfugjw 151 11 in in IN cord-317619-o7qfugjw 151 12 viral viral JJ cord-317619-o7qfugjw 151 13 load load NN cord-317619-o7qfugjw 151 14 ( ( -LRB- cord-317619-o7qfugjw 151 15 93 93 CD cord-317619-o7qfugjw 151 16 ) ) -RRB- cord-317619-o7qfugjw 151 17 . . . cord-317619-o7qfugjw 152 1 In in IN cord-317619-o7qfugjw 152 2 addition addition NN cord-317619-o7qfugjw 152 3 , , , cord-317619-o7qfugjw 152 4 activation activation NN cord-317619-o7qfugjw 152 5 of of IN cord-317619-o7qfugjw 152 6 several several JJ cord-317619-o7qfugjw 152 7 chemokine chemokine NN cord-317619-o7qfugjw 152 8 and and CC cord-317619-o7qfugjw 152 9 interleukin interleukin NN cord-317619-o7qfugjw 152 10 subtypes subtype NNS cord-317619-o7qfugjw 152 11 , , , cord-317619-o7qfugjw 152 12 as as RB cord-317619-o7qfugjw 152 13 well well RB cord-317619-o7qfugjw 152 14 as as IN cord-317619-o7qfugjw 152 15 tumor tumor NN cord-317619-o7qfugjw 152 16 necrosis necrosis NN cord-317619-o7qfugjw 152 17 factors factor NNS cord-317619-o7qfugjw 152 18 , , , cord-317619-o7qfugjw 152 19 has have VBZ cord-317619-o7qfugjw 152 20 been be VBN cord-317619-o7qfugjw 152 21 shown show VBN cord-317619-o7qfugjw 152 22 to to TO cord-317619-o7qfugjw 152 23 positively positively RB cord-317619-o7qfugjw 152 24 correlate correlate VB cord-317619-o7qfugjw 152 25 with with IN cord-317619-o7qfugjw 152 26 severity severity NN cord-317619-o7qfugjw 152 27 of of IN cord-317619-o7qfugjw 152 28 illness illness NN cord-317619-o7qfugjw 152 29 in in IN cord-317619-o7qfugjw 152 30 children child NNS cord-317619-o7qfugjw 152 31 with with IN cord-317619-o7qfugjw 152 32 RSV RSV NNP cord-317619-o7qfugjw 152 33 ( ( -LRB- cord-317619-o7qfugjw 152 34 94 94 CD cord-317619-o7qfugjw 152 35 ) ) -RRB- cord-317619-o7qfugjw 152 36 . . . cord-317619-o7qfugjw 153 1 In in IN cord-317619-o7qfugjw 153 2 their -PRON- PRP$ cord-317619-o7qfugjw 153 3 study study NN cord-317619-o7qfugjw 153 4 , , , cord-317619-o7qfugjw 153 5 Fernandez Fernandez NNP cord-317619-o7qfugjw 153 6 et et NNP cord-317619-o7qfugjw 153 7 al al NNP cord-317619-o7qfugjw 153 8 . . NNP cord-317619-o7qfugjw 153 9 discovered discover VBD cord-317619-o7qfugjw 153 10 that that IN cord-317619-o7qfugjw 153 11 higher high JJR cord-317619-o7qfugjw 153 12 levels level NNS cord-317619-o7qfugjw 153 13 of of IN cord-317619-o7qfugjw 153 14 soluble soluble JJ cord-317619-o7qfugjw 153 15 interleukin-10 interleukin-10 NN cord-317619-o7qfugjw 153 16 ( ( -LRB- cord-317619-o7qfugjw 153 17 IL-10 IL-10 NNP cord-317619-o7qfugjw 153 18 ) ) -RRB- cord-317619-o7qfugjw 153 19 positively positively RB cord-317619-o7qfugjw 153 20 correlated correlate VBN cord-317619-o7qfugjw 153 21 with with IN cord-317619-o7qfugjw 153 22 both both DT cord-317619-o7qfugjw 153 23 disease disease NN cord-317619-o7qfugjw 153 24 severity severity NN cord-317619-o7qfugjw 153 25 and and CC cord-317619-o7qfugjw 153 26 duration duration NN cord-317619-o7qfugjw 153 27 of of IN cord-317619-o7qfugjw 153 28 supplemental supplemental JJ cord-317619-o7qfugjw 153 29 oxygen oxygen NN cord-317619-o7qfugjw 153 30 in in IN cord-317619-o7qfugjw 153 31 infants infant NNS cord-317619-o7qfugjw 153 32 with with IN cord-317619-o7qfugjw 153 33 acute acute JJ cord-317619-o7qfugjw 153 34 RSV RSV NNP cord-317619-o7qfugjw 153 35 infection infection NN cord-317619-o7qfugjw 153 36 ( ( -LRB- cord-317619-o7qfugjw 153 37 95 95 CD cord-317619-o7qfugjw 153 38 ) ) -RRB- cord-317619-o7qfugjw 153 39 . . . cord-317619-o7qfugjw 154 1 A a DT cord-317619-o7qfugjw 154 2 separate separate JJ cord-317619-o7qfugjw 154 3 study study NN cord-317619-o7qfugjw 154 4 confirmed confirm VBD cord-317619-o7qfugjw 154 5 this this DT cord-317619-o7qfugjw 154 6 associate associate NN cord-317619-o7qfugjw 154 7 with with IN cord-317619-o7qfugjw 154 8 increased increase VBN cord-317619-o7qfugjw 154 9 levels level NNS cord-317619-o7qfugjw 154 10 of of IN cord-317619-o7qfugjw 154 11 IL-10 IL-10 NNP cord-317619-o7qfugjw 154 12 in in IN cord-317619-o7qfugjw 154 13 nasopharyngeal nasopharyngeal JJ cord-317619-o7qfugjw 154 14 secretions secretion NNS cord-317619-o7qfugjw 154 15 ( ( -LRB- cord-317619-o7qfugjw 154 16 96 96 CD cord-317619-o7qfugjw 154 17 ) ) -RRB- cord-317619-o7qfugjw 154 18 , , , cord-317619-o7qfugjw 154 19 but but CC cord-317619-o7qfugjw 154 20 the the DT cord-317619-o7qfugjw 154 21 pathogenicity pathogenicity NN cord-317619-o7qfugjw 154 22 of of IN cord-317619-o7qfugjw 154 23 this this DT cord-317619-o7qfugjw 154 24 correlation correlation NN cord-317619-o7qfugjw 154 25 has have VBZ cord-317619-o7qfugjw 154 26 yet yet RB cord-317619-o7qfugjw 154 27 to to TO cord-317619-o7qfugjw 154 28 be be VB cord-317619-o7qfugjw 154 29 determined determine VBN cord-317619-o7qfugjw 154 30 . . . cord-317619-o7qfugjw 155 1 Antigenic antigenic JJ cord-317619-o7qfugjw 155 2 variability variability NN cord-317619-o7qfugjw 155 3 exists exist VBZ cord-317619-o7qfugjw 155 4 with with IN cord-317619-o7qfugjw 155 5 both both DT cord-317619-o7qfugjw 155 6 influenza influenza NN cord-317619-o7qfugjw 155 7 A a NN cord-317619-o7qfugjw 155 8 ( ( -LRB- cord-317619-o7qfugjw 155 9 H1N1 H1N1 NNP cord-317619-o7qfugjw 155 10 ) ) -RRB- cord-317619-o7qfugjw 155 11 virus virus NN cord-317619-o7qfugjw 155 12 and and CC cord-317619-o7qfugjw 155 13 the the DT cord-317619-o7qfugjw 155 14 resultant resultant JJ cord-317619-o7qfugjw 155 15 immune immune NN cord-317619-o7qfugjw 155 16 - - HYPH cord-317619-o7qfugjw 155 17 mediated mediate VBN cord-317619-o7qfugjw 155 18 response response NN cord-317619-o7qfugjw 155 19 . . . cord-317619-o7qfugjw 156 1 Like like IN cord-317619-o7qfugjw 156 2 influenza influenza NN cord-317619-o7qfugjw 156 3 B b NN cord-317619-o7qfugjw 156 4 and and CC cord-317619-o7qfugjw 156 5 C C NNP cord-317619-o7qfugjw 156 6 , , , cord-317619-o7qfugjw 156 7 influenza influenza NN cord-317619-o7qfugjw 156 8 A a NN cord-317619-o7qfugjw 156 9 is be VBZ cord-317619-o7qfugjw 156 10 made make VBN cord-317619-o7qfugjw 156 11 up up RP cord-317619-o7qfugjw 156 12 of of IN cord-317619-o7qfugjw 156 13 structural structural JJ cord-317619-o7qfugjw 156 14 proteins protein NNS cord-317619-o7qfugjw 156 15 and and CC cord-317619-o7qfugjw 156 16 two two CD cord-317619-o7qfugjw 156 17 groups group NNS cord-317619-o7qfugjw 156 18 of of IN cord-317619-o7qfugjw 156 19 surface surface NN cord-317619-o7qfugjw 156 20 glycoproteins glycoprotein NNS cord-317619-o7qfugjw 156 21 , , , cord-317619-o7qfugjw 156 22 hemagglutinin hemagglutinin NNS cord-317619-o7qfugjw 156 23 ( ( -LRB- cord-317619-o7qfugjw 156 24 HA HA NNP cord-317619-o7qfugjw 156 25 ) ) -RRB- cord-317619-o7qfugjw 156 26 , , , cord-317619-o7qfugjw 156 27 and and CC cord-317619-o7qfugjw 156 28 neuraminidase neuraminidase NN cord-317619-o7qfugjw 156 29 ( ( -LRB- cord-317619-o7qfugjw 156 30 NA NA NNP cord-317619-o7qfugjw 156 31 ) ) -RRB- cord-317619-o7qfugjw 156 32 . . . cord-317619-o7qfugjw 157 1 These these DT cord-317619-o7qfugjw 157 2 glycoproteins glycoprotein NNS cord-317619-o7qfugjw 157 3 are be VBP cord-317619-o7qfugjw 157 4 responsible responsible JJ cord-317619-o7qfugjw 157 5 for for IN cord-317619-o7qfugjw 157 6 attachment attachment NN cord-317619-o7qfugjw 157 7 and and CC cord-317619-o7qfugjw 157 8 entry entry NN cord-317619-o7qfugjw 157 9 into into IN cord-317619-o7qfugjw 157 10 cells cell NNS cord-317619-o7qfugjw 157 11 , , , cord-317619-o7qfugjw 157 12 viral viral JJ cord-317619-o7qfugjw 157 13 spread spread NN cord-317619-o7qfugjw 157 14 throughout throughout IN cord-317619-o7qfugjw 157 15 the the DT cord-317619-o7qfugjw 157 16 respiratory respiratory JJ cord-317619-o7qfugjw 157 17 tract tract NN cord-317619-o7qfugjw 157 18 , , , cord-317619-o7qfugjw 157 19 and and CC cord-317619-o7qfugjw 157 20 are be VBP cord-317619-o7qfugjw 157 21 capable capable JJ cord-317619-o7qfugjw 157 22 of of IN cord-317619-o7qfugjw 157 23 a a DT cord-317619-o7qfugjw 157 24 large large JJ cord-317619-o7qfugjw 157 25 degree degree NN cord-317619-o7qfugjw 157 26 of of IN cord-317619-o7qfugjw 157 27 variability variability NN cord-317619-o7qfugjw 157 28 ( ( -LRB- cord-317619-o7qfugjw 157 29 97 97 CD cord-317619-o7qfugjw 157 30 ) ) -RRB- cord-317619-o7qfugjw 157 31 . . . cord-317619-o7qfugjw 158 1 Waterfowl Waterfowl NNS cord-317619-o7qfugjw 158 2 serve serve VBP cord-317619-o7qfugjw 158 3 as as IN cord-317619-o7qfugjw 158 4 the the DT cord-317619-o7qfugjw 158 5 largest large JJS cord-317619-o7qfugjw 158 6 natural natural JJ cord-317619-o7qfugjw 158 7 reservoir reservoir NN cord-317619-o7qfugjw 158 8 for for IN cord-317619-o7qfugjw 158 9 influenza influenza NN cord-317619-o7qfugjw 158 10 A a DT cord-317619-o7qfugjw 158 11 subtypes subtype NNS cord-317619-o7qfugjw 158 12 ( ( -LRB- cord-317619-o7qfugjw 158 13 98 98 CD cord-317619-o7qfugjw 158 14 ) ) -RRB- cord-317619-o7qfugjw 158 15 . . . cord-317619-o7qfugjw 159 1 The the DT cord-317619-o7qfugjw 159 2 avian avian JJ cord-317619-o7qfugjw 159 3 - - HYPH cord-317619-o7qfugjw 159 4 to to IN cord-317619-o7qfugjw 159 5 - - HYPH cord-317619-o7qfugjw 159 6 human human JJ cord-317619-o7qfugjw 159 7 leap leap NN cord-317619-o7qfugjw 159 8 can can MD cord-317619-o7qfugjw 159 9 occur occur VB cord-317619-o7qfugjw 159 10 through through IN cord-317619-o7qfugjw 159 11 direct direct JJ cord-317619-o7qfugjw 159 12 transmission transmission NN cord-317619-o7qfugjw 159 13 ( ( -LRB- cord-317619-o7qfugjw 159 14 99 99 CD cord-317619-o7qfugjw 159 15 ) ) -RRB- cord-317619-o7qfugjw 159 16 or or CC cord-317619-o7qfugjw 159 17 , , , cord-317619-o7qfugjw 159 18 alternatively alternatively RB cord-317619-o7qfugjw 159 19 , , , cord-317619-o7qfugjw 159 20 through through IN cord-317619-o7qfugjw 159 21 pigs pig NNS cord-317619-o7qfugjw 159 22 ( ( -LRB- cord-317619-o7qfugjw 159 23 100 100 CD cord-317619-o7qfugjw 159 24 ) ) -RRB- cord-317619-o7qfugjw 159 25 . . . cord-317619-o7qfugjw 160 1 Although although IN cord-317619-o7qfugjw 160 2 transmission transmission NN cord-317619-o7qfugjw 160 3 from from IN cord-317619-o7qfugjw 160 4 pigs pig NNS cord-317619-o7qfugjw 160 5 to to IN cord-317619-o7qfugjw 160 6 humans human NNS cord-317619-o7qfugjw 160 7 is be VBZ cord-317619-o7qfugjw 160 8 a a DT cord-317619-o7qfugjw 160 9 rare rare JJ cord-317619-o7qfugjw 160 10 event event NN cord-317619-o7qfugjw 160 11 , , , cord-317619-o7qfugjw 160 12 it -PRON- PRP cord-317619-o7qfugjw 160 13 occurred occur VBD cord-317619-o7qfugjw 160 14 in in IN cord-317619-o7qfugjw 160 15 the the DT cord-317619-o7qfugjw 160 16 1918 1918 CD cord-317619-o7qfugjw 160 17 pandemic pandemic NN cord-317619-o7qfugjw 160 18 ( ( -LRB- cord-317619-o7qfugjw 160 19 101 101 CD cord-317619-o7qfugjw 160 20 ) ) -RRB- cord-317619-o7qfugjw 160 21 a a DT cord-317619-o7qfugjw 160 22 small small JJ cord-317619-o7qfugjw 160 23 outbreak outbreak NN cord-317619-o7qfugjw 160 24 in in IN cord-317619-o7qfugjw 160 25 New New NNP cord-317619-o7qfugjw 160 26 Jersey Jersey NNP cord-317619-o7qfugjw 160 27 in in IN cord-317619-o7qfugjw 160 28 1976 1976 CD cord-317619-o7qfugjw 160 29 ( ( -LRB- cord-317619-o7qfugjw 160 30 102 102 CD cord-317619-o7qfugjw 160 31 ) ) -RRB- cord-317619-o7qfugjw 160 32 and and CC cord-317619-o7qfugjw 160 33 the the DT cord-317619-o7qfugjw 160 34 most most RBS cord-317619-o7qfugjw 160 35 recent recent JJ cord-317619-o7qfugjw 160 36 pandemic pandemic NN cord-317619-o7qfugjw 160 37 of of IN cord-317619-o7qfugjw 160 38 influenza influenza NN cord-317619-o7qfugjw 160 39 A a NN cord-317619-o7qfugjw 160 40 ( ( -LRB- cord-317619-o7qfugjw 160 41 H1N1 H1N1 NNP cord-317619-o7qfugjw 160 42 ) ) -RRB- cord-317619-o7qfugjw 160 43 starting start VBG cord-317619-o7qfugjw 160 44 in in IN cord-317619-o7qfugjw 160 45 2009 2009 CD cord-317619-o7qfugjw 160 46 ( ( -LRB- cord-317619-o7qfugjw 160 47 103 103 CD cord-317619-o7qfugjw 160 48 ) ) -RRB- cord-317619-o7qfugjw 160 49 . . . cord-317619-o7qfugjw 161 1 Influenza Influenza NNP cord-317619-o7qfugjw 161 2 A A NNP cord-317619-o7qfugjw 161 3 ( ( -LRB- cord-317619-o7qfugjw 161 4 H1N1 H1N1 NNP cord-317619-o7qfugjw 161 5 ) ) -RRB- cord-317619-o7qfugjw 161 6 virus virus NN cord-317619-o7qfugjw 161 7 primarily primarily RB cord-317619-o7qfugjw 161 8 targets target VBZ cord-317619-o7qfugjw 161 9 alveolar alveolar NN cord-317619-o7qfugjw 161 10 epithelial epithelial JJ cord-317619-o7qfugjw 161 11 cells cell NNS cord-317619-o7qfugjw 161 12 that that WDT cord-317619-o7qfugjw 161 13 serve serve VBP cord-317619-o7qfugjw 161 14 as as IN cord-317619-o7qfugjw 161 15 first first JJ cord-317619-o7qfugjw 161 16 - - HYPH cord-317619-o7qfugjw 161 17 line line NN cord-317619-o7qfugjw 161 18 defense defense NN cord-317619-o7qfugjw 161 19 against against IN cord-317619-o7qfugjw 161 20 respiratory respiratory JJ cord-317619-o7qfugjw 161 21 infections infection NNS cord-317619-o7qfugjw 161 22 ( ( -LRB- cord-317619-o7qfugjw 161 23 104 104 CD cord-317619-o7qfugjw 161 24 ) ) -RRB- cord-317619-o7qfugjw 161 25 . . . cord-317619-o7qfugjw 162 1 Histological histological JJ cord-317619-o7qfugjw 162 2 evaluation evaluation NN cord-317619-o7qfugjw 162 3 of of IN cord-317619-o7qfugjw 162 4 100 100 CD cord-317619-o7qfugjw 162 5 fatal fatal JJ cord-317619-o7qfugjw 162 6 cases case NNS cord-317619-o7qfugjw 162 7 of of IN cord-317619-o7qfugjw 162 8 influenza influenza NN cord-317619-o7qfugjw 162 9 A a NN cord-317619-o7qfugjw 162 10 ( ( -LRB- cord-317619-o7qfugjw 162 11 H1N1 H1N1 NNP cord-317619-o7qfugjw 162 12 ) ) -RRB- cord-317619-o7qfugjw 162 13 virus virus NN cord-317619-o7qfugjw 162 14 infection infection NN cord-317619-o7qfugjw 162 15 revealed reveal VBD cord-317619-o7qfugjw 162 16 diffuse diffuse JJ cord-317619-o7qfugjw 162 17 alveolar alveolar NN cord-317619-o7qfugjw 162 18 damage damage NN cord-317619-o7qfugjw 162 19 with with IN cord-317619-o7qfugjw 162 20 inflammation inflammation NN cord-317619-o7qfugjw 162 21 , , , cord-317619-o7qfugjw 162 22 fibrosis fibrosis NN cord-317619-o7qfugjw 162 23 and and CC cord-317619-o7qfugjw 162 24 edema edema NN cord-317619-o7qfugjw 162 25 , , , cord-317619-o7qfugjw 162 26 disruption disruption NN cord-317619-o7qfugjw 162 27 of of IN cord-317619-o7qfugjw 162 28 surfactant surfactant NN cord-317619-o7qfugjw 162 29 production production NN cord-317619-o7qfugjw 162 30 , , , cord-317619-o7qfugjw 162 31 and and CC cord-317619-o7qfugjw 162 32 detection detection NN cord-317619-o7qfugjw 162 33 of of IN cord-317619-o7qfugjw 162 34 viral viral JJ cord-317619-o7qfugjw 162 35 antigens antigen NNS cord-317619-o7qfugjw 162 36 throughout throughout IN cord-317619-o7qfugjw 162 37 the the DT cord-317619-o7qfugjw 162 38 lung lung NN cord-317619-o7qfugjw 162 39 parenchyma parenchyma NN cord-317619-o7qfugjw 162 40 ( ( -LRB- cord-317619-o7qfugjw 162 41 105 105 CD cord-317619-o7qfugjw 162 42 ) ) -RRB- cord-317619-o7qfugjw 162 43 . . . cord-317619-o7qfugjw 163 1 Like like IN cord-317619-o7qfugjw 163 2 RSV RSV NNP cord-317619-o7qfugjw 163 3 , , , cord-317619-o7qfugjw 163 4 this this DT cord-317619-o7qfugjw 163 5 pathogenic pathogenic NN cord-317619-o7qfugjw 163 6 can can MD cord-317619-o7qfugjw 163 7 process process VB cord-317619-o7qfugjw 163 8 rapidly rapidly RB cord-317619-o7qfugjw 163 9 progresses progress VBZ cord-317619-o7qfugjw 163 10 to to IN cord-317619-o7qfugjw 163 11 refractory refractory JJ cord-317619-o7qfugjw 163 12 hypoxemia hypoxemia NN cord-317619-o7qfugjw 163 13 and and CC cord-317619-o7qfugjw 163 14 ARDS ARDS NNP cord-317619-o7qfugjw 163 15 ( ( -LRB- cord-317619-o7qfugjw 163 16 106 106 CD cord-317619-o7qfugjw 163 17 ) ) -RRB- cord-317619-o7qfugjw 163 18 . . . cord-317619-o7qfugjw 164 1 In in IN cord-317619-o7qfugjw 164 2 addition addition NN cord-317619-o7qfugjw 164 3 to to IN cord-317619-o7qfugjw 164 4 viral viral JJ cord-317619-o7qfugjw 164 5 pathogenicity pathogenicity NN cord-317619-o7qfugjw 164 6 , , , cord-317619-o7qfugjw 164 7 disease disease NN cord-317619-o7qfugjw 164 8 severity severity NN cord-317619-o7qfugjw 164 9 of of IN cord-317619-o7qfugjw 164 10 influenza influenza NN cord-317619-o7qfugjw 164 11 A a NN cord-317619-o7qfugjw 164 12 ( ( -LRB- cord-317619-o7qfugjw 164 13 H1N1 H1N1 NNP cord-317619-o7qfugjw 164 14 ) ) -RRB- cord-317619-o7qfugjw 164 15 virus virus NN cord-317619-o7qfugjw 164 16 infection infection NN cord-317619-o7qfugjw 164 17 is be VBZ cord-317619-o7qfugjw 164 18 also also RB cord-317619-o7qfugjw 164 19 closely closely RB cord-317619-o7qfugjw 164 20 associated associate VBN cord-317619-o7qfugjw 164 21 with with IN cord-317619-o7qfugjw 164 22 host host NN cord-317619-o7qfugjw 164 23 response response NN cord-317619-o7qfugjw 164 24 ( ( -LRB- cord-317619-o7qfugjw 164 25 107 107 CD cord-317619-o7qfugjw 164 26 ) ) -RRB- cord-317619-o7qfugjw 164 27 . . . cord-317619-o7qfugjw 165 1 In in IN cord-317619-o7qfugjw 165 2 both both DT cord-317619-o7qfugjw 165 3 healthy healthy JJ cord-317619-o7qfugjw 165 4 patients patient NNS cord-317619-o7qfugjw 165 5 and and CC cord-317619-o7qfugjw 165 6 those those DT cord-317619-o7qfugjw 165 7 with with IN cord-317619-o7qfugjw 165 8 comorbidities comorbiditie NNS cord-317619-o7qfugjw 165 9 , , , cord-317619-o7qfugjw 165 10 influenza influenza NN cord-317619-o7qfugjw 165 11 A a NN cord-317619-o7qfugjw 165 12 ( ( -LRB- cord-317619-o7qfugjw 165 13 H1N1 H1N1 NNP cord-317619-o7qfugjw 165 14 ) ) -RRB- cord-317619-o7qfugjw 165 15 virus virus NN cord-317619-o7qfugjw 165 16 can can MD cord-317619-o7qfugjw 165 17 lead lead VB cord-317619-o7qfugjw 165 18 to to IN cord-317619-o7qfugjw 165 19 an an DT cord-317619-o7qfugjw 165 20 exaggerated exaggerated JJ cord-317619-o7qfugjw 165 21 inflammatory inflammatory JJ cord-317619-o7qfugjw 165 22 response response NN cord-317619-o7qfugjw 165 23 with with IN cord-317619-o7qfugjw 165 24 dysregulation dysregulation NN cord-317619-o7qfugjw 165 25 of of IN cord-317619-o7qfugjw 165 26 local local JJ cord-317619-o7qfugjw 165 27 and and CC cord-317619-o7qfugjw 165 28 systemic systemic JJ cord-317619-o7qfugjw 165 29 chemokine chemokine NN cord-317619-o7qfugjw 165 30 and and CC cord-317619-o7qfugjw 165 31 cytokine cytokine NN cord-317619-o7qfugjw 165 32 production production NN cord-317619-o7qfugjw 165 33 ( ( -LRB- cord-317619-o7qfugjw 165 34 108 108 CD cord-317619-o7qfugjw 165 35 , , , cord-317619-o7qfugjw 165 36 109 109 CD cord-317619-o7qfugjw 165 37 ) ) -RRB- cord-317619-o7qfugjw 165 38 . . . cord-317619-o7qfugjw 166 1 In in IN cord-317619-o7qfugjw 166 2 a a DT cord-317619-o7qfugjw 166 3 study study NN cord-317619-o7qfugjw 166 4 specifically specifically RB cord-317619-o7qfugjw 166 5 in in IN cord-317619-o7qfugjw 166 6 the the DT cord-317619-o7qfugjw 166 7 pediatric pediatric JJ cord-317619-o7qfugjw 166 8 population population NN cord-317619-o7qfugjw 166 9 , , , cord-317619-o7qfugjw 166 10 Takano Takano NNP cord-317619-o7qfugjw 166 11 et et NNP cord-317619-o7qfugjw 166 12 al al NNP cord-317619-o7qfugjw 166 13 . . NNP cord-317619-o7qfugjw 166 14 found find VBD cord-317619-o7qfugjw 166 15 a a DT cord-317619-o7qfugjw 166 16 positive positive JJ cord-317619-o7qfugjw 166 17 correlation correlation NN cord-317619-o7qfugjw 166 18 with with IN cord-317619-o7qfugjw 166 19 disease disease NN cord-317619-o7qfugjw 166 20 severity severity NN cord-317619-o7qfugjw 166 21 and and CC cord-317619-o7qfugjw 166 22 elevated elevated JJ cord-317619-o7qfugjw 166 23 levels level NNS cord-317619-o7qfugjw 166 24 of of IN cord-317619-o7qfugjw 166 25 serum serum NN cord-317619-o7qfugjw 166 26 interferon interferon NN cord-317619-o7qfugjw 166 27 gamma gamma NN cord-317619-o7qfugjw 166 28 , , , cord-317619-o7qfugjw 166 29 several several JJ cord-317619-o7qfugjw 166 30 interleukin interleukin NN cord-317619-o7qfugjw 166 31 types type NNS cord-317619-o7qfugjw 166 32 , , , cord-317619-o7qfugjw 166 33 and and CC cord-317619-o7qfugjw 166 34 monocyte monocyte NNP cord-317619-o7qfugjw 166 35 chemoattractant chemoattractant NNP cord-317619-o7qfugjw 166 36 protein-1 protein-1 NNP cord-317619-o7qfugjw 166 37 ( ( -LRB- cord-317619-o7qfugjw 166 38 MCP-1 MCP-1 NNP cord-317619-o7qfugjw 166 39 ) ) -RRB- cord-317619-o7qfugjw 166 40 ( ( -LRB- cord-317619-o7qfugjw 166 41 110 110 CD cord-317619-o7qfugjw 166 42 ) ) -RRB- cord-317619-o7qfugjw 166 43 . . . cord-317619-o7qfugjw 167 1 Some some DT cord-317619-o7qfugjw 167 2 studies study NNS cord-317619-o7qfugjw 167 3 suggest suggest VBP cord-317619-o7qfugjw 167 4 that that IN cord-317619-o7qfugjw 167 5 these these DT cord-317619-o7qfugjw 167 6 elevations elevation NNS cord-317619-o7qfugjw 167 7 may may MD cord-317619-o7qfugjw 167 8 be be VB cord-317619-o7qfugjw 167 9 adequate adequate JJ cord-317619-o7qfugjw 167 10 immune immune JJ cord-317619-o7qfugjw 167 11 response response NN cord-317619-o7qfugjw 167 12 to to IN cord-317619-o7qfugjw 167 13 infection infection NN cord-317619-o7qfugjw 167 14 ( ( -LRB- cord-317619-o7qfugjw 167 15 111 111 CD cord-317619-o7qfugjw 167 16 ) ) -RRB- cord-317619-o7qfugjw 167 17 , , , cord-317619-o7qfugjw 167 18 but but CC cord-317619-o7qfugjw 167 19 further further JJ cord-317619-o7qfugjw 167 20 exploration exploration NN cord-317619-o7qfugjw 167 21 of of IN cord-317619-o7qfugjw 167 22 the the DT cord-317619-o7qfugjw 167 23 inflammatory inflammatory JJ cord-317619-o7qfugjw 167 24 response response NN cord-317619-o7qfugjw 167 25 in in IN cord-317619-o7qfugjw 167 26 influenza influenza NN cord-317619-o7qfugjw 167 27 A a NN cord-317619-o7qfugjw 167 28 ( ( -LRB- cord-317619-o7qfugjw 167 29 H1N1 H1N1 NNP cord-317619-o7qfugjw 167 30 ) ) -RRB- cord-317619-o7qfugjw 167 31 virus virus NN cord-317619-o7qfugjw 167 32 infection infection NN cord-317619-o7qfugjw 167 33 is be VBZ cord-317619-o7qfugjw 167 34 likely likely JJ cord-317619-o7qfugjw 167 35 to to TO cord-317619-o7qfugjw 167 36 yield yield VB cord-317619-o7qfugjw 167 37 development development NN cord-317619-o7qfugjw 167 38 of of IN cord-317619-o7qfugjw 167 39 potential potential JJ cord-317619-o7qfugjw 167 40 interventions intervention NNS cord-317619-o7qfugjw 167 41 to to TO cord-317619-o7qfugjw 167 42 prevent prevent VB cord-317619-o7qfugjw 167 43 disease disease NN cord-317619-o7qfugjw 167 44 progression progression NN cord-317619-o7qfugjw 167 45 to to IN cord-317619-o7qfugjw 167 46 ARDS ARDS NNP cord-317619-o7qfugjw 167 47 . . . cord-317619-o7qfugjw 168 1 The the DT cord-317619-o7qfugjw 168 2 treatment treatment NN cord-317619-o7qfugjw 168 3 of of IN cord-317619-o7qfugjw 168 4 ARDS ARDS NNP cord-317619-o7qfugjw 168 5 has have VBZ cord-317619-o7qfugjw 168 6 significantly significantly RB cord-317619-o7qfugjw 168 7 evolved evolve VBN cord-317619-o7qfugjw 168 8 over over IN cord-317619-o7qfugjw 168 9 the the DT cord-317619-o7qfugjw 168 10 past past JJ cord-317619-o7qfugjw 168 11 several several JJ cord-317619-o7qfugjw 168 12 decades decade NNS cord-317619-o7qfugjw 168 13 . . . cord-317619-o7qfugjw 169 1 Perhaps perhaps RB cord-317619-o7qfugjw 169 2 the the DT cord-317619-o7qfugjw 169 3 greatest great JJS cord-317619-o7qfugjw 169 4 improvement improvement NN cord-317619-o7qfugjw 169 5 in in IN cord-317619-o7qfugjw 169 6 management management NN cord-317619-o7qfugjw 169 7 developed develop VBN cord-317619-o7qfugjw 169 8 from from IN cord-317619-o7qfugjw 169 9 studies study NNS cord-317619-o7qfugjw 169 10 involving involve VBG cord-317619-o7qfugjw 169 11 lung lung NN cord-317619-o7qfugjw 169 12 - - HYPH cord-317619-o7qfugjw 169 13 protective protective JJ cord-317619-o7qfugjw 169 14 ventilation ventilation NN cord-317619-o7qfugjw 169 15 ( ( -LRB- cord-317619-o7qfugjw 169 16 9 9 CD cord-317619-o7qfugjw 169 17 ) ) -RRB- cord-317619-o7qfugjw 169 18 . . . cord-317619-o7qfugjw 170 1 Other other JJ cord-317619-o7qfugjw 170 2 interventions intervention NNS cord-317619-o7qfugjw 170 3 such such JJ cord-317619-o7qfugjw 170 4 as as IN cord-317619-o7qfugjw 170 5 inhaled inhale VBN cord-317619-o7qfugjw 170 6 nitric nitric NN cord-317619-o7qfugjw 170 7 oxide oxide NN cord-317619-o7qfugjw 170 8 ( ( -LRB- cord-317619-o7qfugjw 170 9 112 112 CD cord-317619-o7qfugjw 170 10 ) ) -RRB- cord-317619-o7qfugjw 170 11 , , , cord-317619-o7qfugjw 170 12 fluid fluid JJ cord-317619-o7qfugjw 170 13 management management NN cord-317619-o7qfugjw 170 14 ( ( -LRB- cord-317619-o7qfugjw 170 15 113 113 CD cord-317619-o7qfugjw 170 16 ) ) -RRB- cord-317619-o7qfugjw 170 17 , , , cord-317619-o7qfugjw 170 18 use use NN cord-317619-o7qfugjw 170 19 of of IN cord-317619-o7qfugjw 170 20 steroids steroid NNS cord-317619-o7qfugjw 170 21 ( ( -LRB- cord-317619-o7qfugjw 170 22 114 114 CD cord-317619-o7qfugjw 170 23 ) ) -RRB- cord-317619-o7qfugjw 170 24 , , , cord-317619-o7qfugjw 170 25 and and CC cord-317619-o7qfugjw 170 26 prone prone JJ cord-317619-o7qfugjw 170 27 positioning positioning NN cord-317619-o7qfugjw 170 28 ( ( -LRB- cord-317619-o7qfugjw 170 29 115 115 CD cord-317619-o7qfugjw 170 30 ) ) -RRB- cord-317619-o7qfugjw 170 31 are be VBP cord-317619-o7qfugjw 170 32 being be VBG cord-317619-o7qfugjw 170 33 further further RB cord-317619-o7qfugjw 170 34 investigated investigate VBN cord-317619-o7qfugjw 170 35 and and CC cord-317619-o7qfugjw 170 36 validated validate VBN cord-317619-o7qfugjw 170 37 . . . cord-317619-o7qfugjw 171 1 However however RB cord-317619-o7qfugjw 171 2 , , , cord-317619-o7qfugjw 171 3 specific specific JJ cord-317619-o7qfugjw 171 4 treatment treatment NN cord-317619-o7qfugjw 171 5 for for IN cord-317619-o7qfugjw 171 6 RSV RSV NNP cord-317619-o7qfugjw 171 7 infection infection NN cord-317619-o7qfugjw 171 8 remains remain VBZ cord-317619-o7qfugjw 171 9 lacking lack VBG cord-317619-o7qfugjw 171 10 . . . cord-317619-o7qfugjw 172 1 Despite despite IN cord-317619-o7qfugjw 172 2 the the DT cord-317619-o7qfugjw 172 3 substantial substantial JJ cord-317619-o7qfugjw 172 4 short short JJ cord-317619-o7qfugjw 172 5 and and CC cord-317619-o7qfugjw 172 6 long long JJ cord-317619-o7qfugjw 172 7 - - HYPH cord-317619-o7qfugjw 172 8 term term NN cord-317619-o7qfugjw 172 9 morbidity morbidity NN cord-317619-o7qfugjw 172 10 and and CC cord-317619-o7qfugjw 172 11 mortality mortality NN cord-317619-o7qfugjw 172 12 associated associate VBN cord-317619-o7qfugjw 172 13 with with IN cord-317619-o7qfugjw 172 14 RSV RSV NNP cord-317619-o7qfugjw 172 15 disease disease NN cord-317619-o7qfugjw 172 16 in in IN cord-317619-o7qfugjw 172 17 children child NNS cord-317619-o7qfugjw 172 18 , , , cord-317619-o7qfugjw 172 19 the the DT cord-317619-o7qfugjw 172 20 current current JJ cord-317619-o7qfugjw 172 21 management management NN cord-317619-o7qfugjw 172 22 for for IN cord-317619-o7qfugjw 172 23 RSV RSV NNP cord-317619-o7qfugjw 172 24 infection infection NN cord-317619-o7qfugjw 172 25 consists consist VBZ cord-317619-o7qfugjw 172 26 of of IN cord-317619-o7qfugjw 172 27 supportive supportive JJ cord-317619-o7qfugjw 172 28 care care NN cord-317619-o7qfugjw 172 29 , , , cord-317619-o7qfugjw 172 30 in in IN cord-317619-o7qfugjw 172 31 the the DT cord-317619-o7qfugjw 172 32 form form NN cord-317619-o7qfugjw 172 33 of of IN cord-317619-o7qfugjw 172 34 oxygen oxygen NN cord-317619-o7qfugjw 172 35 supplementation supplementation NN cord-317619-o7qfugjw 172 36 , , , cord-317619-o7qfugjw 172 37 adequate adequate JJ cord-317619-o7qfugjw 172 38 hydration hydration NN cord-317619-o7qfugjw 172 39 , , , cord-317619-o7qfugjw 172 40 and and CC cord-317619-o7qfugjw 172 41 mechanical mechanical JJ cord-317619-o7qfugjw 172 42 ventilation ventilation NN cord-317619-o7qfugjw 172 43 for for IN cord-317619-o7qfugjw 172 44 those those DT cord-317619-o7qfugjw 172 45 who who WP cord-317619-o7qfugjw 172 46 develop develop VBP cord-317619-o7qfugjw 172 47 respiratory respiratory JJ cord-317619-o7qfugjw 172 48 failure failure NN cord-317619-o7qfugjw 172 49 . . . cord-317619-o7qfugjw 173 1 Multiple multiple JJ cord-317619-o7qfugjw 173 2 therapeutic therapeutic JJ cord-317619-o7qfugjw 173 3 strategies strategy NNS cord-317619-o7qfugjw 173 4 have have VBP cord-317619-o7qfugjw 173 5 been be VBN cord-317619-o7qfugjw 173 6 explored explore VBN cord-317619-o7qfugjw 173 7 with with IN cord-317619-o7qfugjw 173 8 very very RB cord-317619-o7qfugjw 173 9 limited limited JJ cord-317619-o7qfugjw 173 10 success success NN cord-317619-o7qfugjw 173 11 , , , cord-317619-o7qfugjw 173 12 and and CC cord-317619-o7qfugjw 173 13 a a DT cord-317619-o7qfugjw 173 14 vital vital JJ cord-317619-o7qfugjw 173 15 need need NN cord-317619-o7qfugjw 173 16 remains remain VBZ cord-317619-o7qfugjw 173 17 for for IN cord-317619-o7qfugjw 173 18 an an DT cord-317619-o7qfugjw 173 19 effective effective JJ cord-317619-o7qfugjw 173 20 disease disease NN cord-317619-o7qfugjw 173 21 treatment treatment NN cord-317619-o7qfugjw 173 22 . . . cord-317619-o7qfugjw 174 1 Interventions intervention NNS cord-317619-o7qfugjw 174 2 for for IN cord-317619-o7qfugjw 174 3 either either DT cord-317619-o7qfugjw 174 4 virus virus NN cord-317619-o7qfugjw 174 5 can can MD cord-317619-o7qfugjw 174 6 be be VB cord-317619-o7qfugjw 174 7 separated separate VBN cord-317619-o7qfugjw 174 8 into into IN cord-317619-o7qfugjw 174 9 primary primary JJ cord-317619-o7qfugjw 174 10 prevention prevention NN cord-317619-o7qfugjw 174 11 of of IN cord-317619-o7qfugjw 174 12 infection infection NN cord-317619-o7qfugjw 174 13 , , , cord-317619-o7qfugjw 174 14 typically typically RB cord-317619-o7qfugjw 174 15 through through IN cord-317619-o7qfugjw 174 16 vaccination vaccination NN cord-317619-o7qfugjw 174 17 , , , cord-317619-o7qfugjw 174 18 and and CC cord-317619-o7qfugjw 174 19 reduction reduction NN cord-317619-o7qfugjw 174 20 of of IN cord-317619-o7qfugjw 174 21 infectious infectious JJ cord-317619-o7qfugjw 174 22 burden burden NN cord-317619-o7qfugjw 174 23 once once IN cord-317619-o7qfugjw 174 24 transmission transmission NN cord-317619-o7qfugjw 174 25 has have VBZ cord-317619-o7qfugjw 174 26 already already RB cord-317619-o7qfugjw 174 27 taken take VBN cord-317619-o7qfugjw 174 28 place place NN cord-317619-o7qfugjw 174 29 . . . cord-317619-o7qfugjw 175 1 Primary primary JJ cord-317619-o7qfugjw 175 2 prevention prevention NN cord-317619-o7qfugjw 175 3 through through IN cord-317619-o7qfugjw 175 4 vaccination vaccination NN cord-317619-o7qfugjw 175 5 continues continue VBZ cord-317619-o7qfugjw 175 6 to to TO cord-317619-o7qfugjw 175 7 be be VB cord-317619-o7qfugjw 175 8 a a DT cord-317619-o7qfugjw 175 9 major major JJ cord-317619-o7qfugjw 175 10 area area NN cord-317619-o7qfugjw 175 11 of of IN cord-317619-o7qfugjw 175 12 research research NN cord-317619-o7qfugjw 175 13 and and CC cord-317619-o7qfugjw 175 14 potential potential JJ cord-317619-o7qfugjw 175 15 advancement advancement NN cord-317619-o7qfugjw 175 16 for for IN cord-317619-o7qfugjw 175 17 both both CC cord-317619-o7qfugjw 175 18 RSV RSV NNP cord-317619-o7qfugjw 175 19 and and CC cord-317619-o7qfugjw 175 20 influenza influenza NN cord-317619-o7qfugjw 175 21 A a NN cord-317619-o7qfugjw 175 22 ( ( -LRB- cord-317619-o7qfugjw 175 23 H1N1 H1N1 NNP cord-317619-o7qfugjw 175 24 ) ) -RRB- cord-317619-o7qfugjw 175 25 virus virus NN cord-317619-o7qfugjw 175 26 . . . cord-317619-o7qfugjw 176 1 To to IN cord-317619-o7qfugjw 176 2 date date NN cord-317619-o7qfugjw 176 3 , , , cord-317619-o7qfugjw 176 4 no no DT cord-317619-o7qfugjw 176 5 RSV RSV NNP cord-317619-o7qfugjw 176 6 vaccine vaccine NN cord-317619-o7qfugjw 176 7 has have VBZ cord-317619-o7qfugjw 176 8 proven prove VBN cord-317619-o7qfugjw 176 9 efficacious efficacious JJ cord-317619-o7qfugjw 176 10 . . . cord-317619-o7qfugjw 177 1 While while IN cord-317619-o7qfugjw 177 2 significant significant JJ cord-317619-o7qfugjw 177 3 research research NN cord-317619-o7qfugjw 177 4 has have VBZ cord-317619-o7qfugjw 177 5 been be VBN cord-317619-o7qfugjw 177 6 devoted devote VBN cord-317619-o7qfugjw 177 7 to to IN cord-317619-o7qfugjw 177 8 vaccine vaccine NN cord-317619-o7qfugjw 177 9 development development NN cord-317619-o7qfugjw 177 10 , , , cord-317619-o7qfugjw 177 11 major major JJ cord-317619-o7qfugjw 177 12 obstacles obstacle NNS cord-317619-o7qfugjw 177 13 specific specific JJ cord-317619-o7qfugjw 177 14 to to IN cord-317619-o7qfugjw 177 15 RSV RSV NNP cord-317619-o7qfugjw 177 16 , , , cord-317619-o7qfugjw 177 17 such such JJ cord-317619-o7qfugjw 177 18 as as IN cord-317619-o7qfugjw 177 19 young young JJ cord-317619-o7qfugjw 177 20 age age NN cord-317619-o7qfugjw 177 21 of of IN cord-317619-o7qfugjw 177 22 infection infection NN cord-317619-o7qfugjw 177 23 , , , cord-317619-o7qfugjw 177 24 lack lack NN cord-317619-o7qfugjw 177 25 of of IN cord-317619-o7qfugjw 177 26 persistent persistent JJ cord-317619-o7qfugjw 177 27 immunity immunity NN cord-317619-o7qfugjw 177 28 , , , cord-317619-o7qfugjw 177 29 and and CC cord-317619-o7qfugjw 177 30 poorly poorly RB cord-317619-o7qfugjw 177 31 validated validate VBN cord-317619-o7qfugjw 177 32 animal animal NN cord-317619-o7qfugjw 177 33 models model NNS cord-317619-o7qfugjw 177 34 make make VBP cord-317619-o7qfugjw 177 35 it -PRON- PRP cord-317619-o7qfugjw 177 36 difficult difficult JJ cord-317619-o7qfugjw 177 37 to to TO cord-317619-o7qfugjw 177 38 find find VB cord-317619-o7qfugjw 177 39 an an DT cord-317619-o7qfugjw 177 40 effective effective JJ cord-317619-o7qfugjw 177 41 and and CC cord-317619-o7qfugjw 177 42 safe safe JJ cord-317619-o7qfugjw 177 43 solution solution NN cord-317619-o7qfugjw 177 44 ( ( -LRB- cord-317619-o7qfugjw 177 45 116 116 CD cord-317619-o7qfugjw 177 46 ) ) -RRB- cord-317619-o7qfugjw 177 47 . . . cord-317619-o7qfugjw 178 1 One one CD cord-317619-o7qfugjw 178 2 current current JJ cord-317619-o7qfugjw 178 3 prospect prospect NN cord-317619-o7qfugjw 178 4 , , , cord-317619-o7qfugjw 178 5 Medi-534 medi-534 CD cord-317619-o7qfugjw 178 6 , , , cord-317619-o7qfugjw 178 7 a a DT cord-317619-o7qfugjw 178 8 liveattenuated liveattenuate VBN cord-317619-o7qfugjw 178 9 , , , cord-317619-o7qfugjw 178 10 intranasal intranasal NN cord-317619-o7qfugjw 178 11 vaccine vaccine NN cord-317619-o7qfugjw 178 12 providing provide VBG cord-317619-o7qfugjw 178 13 protection protection NN cord-317619-o7qfugjw 178 14 against against IN cord-317619-o7qfugjw 178 15 both both CC cord-317619-o7qfugjw 178 16 RSV RSV NNP cord-317619-o7qfugjw 178 17 and and CC cord-317619-o7qfugjw 178 18 parainfluenza parainfluenza NNP cord-317619-o7qfugjw 178 19 3 3 CD cord-317619-o7qfugjw 178 20 , , , cord-317619-o7qfugjw 178 21 although although IN cord-317619-o7qfugjw 178 22 safe safe JJ cord-317619-o7qfugjw 178 23 in in IN cord-317619-o7qfugjw 178 24 children child NNS cord-317619-o7qfugjw 178 25 ages age NNS cord-317619-o7qfugjw 178 26 1 1 CD cord-317619-o7qfugjw 178 27 - - SYM cord-317619-o7qfugjw 178 28 9 9 CD cord-317619-o7qfugjw 178 29 , , , cord-317619-o7qfugjw 178 30 has have VBZ cord-317619-o7qfugjw 178 31 yet yet RB cord-317619-o7qfugjw 178 32 to to TO cord-317619-o7qfugjw 178 33 show show VB cord-317619-o7qfugjw 178 34 a a DT cord-317619-o7qfugjw 178 35 beneficial beneficial JJ cord-317619-o7qfugjw 178 36 immunogenic immunogenic JJ cord-317619-o7qfugjw 178 37 response response NN cord-317619-o7qfugjw 178 38 in in IN cord-317619-o7qfugjw 178 39 infants infant NNS cord-317619-o7qfugjw 178 40 ( ( -LRB- cord-317619-o7qfugjw 178 41 117 117 CD cord-317619-o7qfugjw 178 42 ) ) -RRB- cord-317619-o7qfugjw 178 43 . . . cord-317619-o7qfugjw 179 1 Other other JJ cord-317619-o7qfugjw 179 2 more more JJR cord-317619-o7qfugjw 179 3 recent recent JJ cord-317619-o7qfugjw 179 4 advances advance NNS cord-317619-o7qfugjw 179 5 continue continue VBP cord-317619-o7qfugjw 179 6 to to TO cord-317619-o7qfugjw 179 7 focus focus VB cord-317619-o7qfugjw 179 8 on on IN cord-317619-o7qfugjw 179 9 live live RB cord-317619-o7qfugjw 179 10 - - HYPH cord-317619-o7qfugjw 179 11 attenuated attenuate VBN cord-317619-o7qfugjw 179 12 vaccines vaccine NNS cord-317619-o7qfugjw 179 13 , , , cord-317619-o7qfugjw 179 14 as as RB cord-317619-o7qfugjw 179 15 well well RB cord-317619-o7qfugjw 179 16 as as IN cord-317619-o7qfugjw 179 17 chimeric chimeric JJ cord-317619-o7qfugjw 179 18 live live JJ cord-317619-o7qfugjw 179 19 vectors vector NNS cord-317619-o7qfugjw 179 20 ( ( -LRB- cord-317619-o7qfugjw 179 21 118 118 CD cord-317619-o7qfugjw 179 22 ) ) -RRB- cord-317619-o7qfugjw 179 23 , , , cord-317619-o7qfugjw 179 24 with with IN cord-317619-o7qfugjw 179 25 varying vary VBG cord-317619-o7qfugjw 179 26 antibody antibody NN cord-317619-o7qfugjw 179 27 response response NN cord-317619-o7qfugjw 179 28 between between IN cord-317619-o7qfugjw 179 29 children child NNS cord-317619-o7qfugjw 179 30 ( ( -LRB- cord-317619-o7qfugjw 179 31 119 119 CD cord-317619-o7qfugjw 179 32 , , , cord-317619-o7qfugjw 179 33 120 120 CD cord-317619-o7qfugjw 179 34 ) ) -RRB- cord-317619-o7qfugjw 179 35 . . . cord-317619-o7qfugjw 180 1 While while IN cord-317619-o7qfugjw 180 2 vaccine vaccine NN cord-317619-o7qfugjw 180 3 development development NN cord-317619-o7qfugjw 180 4 continues continue VBZ cord-317619-o7qfugjw 180 5 , , , cord-317619-o7qfugjw 180 6 prophylactic prophylactic JJ cord-317619-o7qfugjw 180 7 use use NN cord-317619-o7qfugjw 180 8 of of IN cord-317619-o7qfugjw 180 9 polyclonal polyclonal JJ cord-317619-o7qfugjw 180 10 RSV rsv NN cord-317619-o7qfugjw 180 11 intravenous intravenous JJ cord-317619-o7qfugjw 180 12 immunoglobulin immunoglobulin NN cord-317619-o7qfugjw 180 13 ( ( -LRB- cord-317619-o7qfugjw 180 14 RespiGam RespiGam NNP cord-317619-o7qfugjw 180 15 ) ) -RRB- cord-317619-o7qfugjw 180 16 or or CC cord-317619-o7qfugjw 180 17 human human JJ cord-317619-o7qfugjw 180 18 anti anti JJ cord-317619-o7qfugjw 180 19 - - JJ cord-317619-o7qfugjw 180 20 F f JJ cord-317619-o7qfugjw 180 21 monoclonal monoclonal JJ cord-317619-o7qfugjw 180 22 antibodies antibody NNS cord-317619-o7qfugjw 180 23 ( ( -LRB- cord-317619-o7qfugjw 180 24 palivizumab palivizumab NNP cord-317619-o7qfugjw 180 25 and and CC cord-317619-o7qfugjw 180 26 motavizumab motavizumab NNP cord-317619-o7qfugjw 181 1 -which -which NNP cord-317619-o7qfugjw 181 2 is be VBZ cord-317619-o7qfugjw 181 3 not not RB cord-317619-o7qfugjw 181 4 yet yet RB cord-317619-o7qfugjw 181 5 licensed license VBN cord-317619-o7qfugjw 181 6 for for IN cord-317619-o7qfugjw 181 7 use use NN cord-317619-o7qfugjw 181 8 ) ) -RRB- cord-317619-o7qfugjw 181 9 in in IN cord-317619-o7qfugjw 181 10 high high JJ cord-317619-o7qfugjw 181 11 - - HYPH cord-317619-o7qfugjw 181 12 risk risk NN cord-317619-o7qfugjw 181 13 infants infant NNS cord-317619-o7qfugjw 181 14 has have VBZ cord-317619-o7qfugjw 181 15 been be VBN cord-317619-o7qfugjw 181 16 shown show VBN cord-317619-o7qfugjw 181 17 to to TO cord-317619-o7qfugjw 181 18 reduce reduce VB cord-317619-o7qfugjw 181 19 the the DT cord-317619-o7qfugjw 181 20 risk risk NN cord-317619-o7qfugjw 181 21 of of IN cord-317619-o7qfugjw 181 22 RSV RSV NNP cord-317619-o7qfugjw 181 23 - - HYPH cord-317619-o7qfugjw 181 24 associated associate VBN cord-317619-o7qfugjw 181 25 acute acute JJ cord-317619-o7qfugjw 181 26 lower low JJR cord-317619-o7qfugjw 181 27 respiratory respiratory JJ cord-317619-o7qfugjw 181 28 tract tract NN cord-317619-o7qfugjw 181 29 infections infection NNS cord-317619-o7qfugjw 181 30 and and CC cord-317619-o7qfugjw 181 31 disease disease NN cord-317619-o7qfugjw 181 32 severity severity NN cord-317619-o7qfugjw 181 33 ( ( -LRB- cord-317619-o7qfugjw 181 34 121 121 CD cord-317619-o7qfugjw 181 35 ) ) -RRB- cord-317619-o7qfugjw 181 36 . . . cord-317619-o7qfugjw 182 1 Palivizumab Palivizumab NNP cord-317619-o7qfugjw 182 2 is be VBZ cord-317619-o7qfugjw 182 3 a a DT cord-317619-o7qfugjw 182 4 human human JJ cord-317619-o7qfugjw 182 5 , , , cord-317619-o7qfugjw 182 6 monoclonal monoclonal JJ cord-317619-o7qfugjw 182 7 antibody antibody NN cord-317619-o7qfugjw 182 8 targeted target VBN cord-317619-o7qfugjw 182 9 to to TO cord-317619-o7qfugjw 182 10 block block VB cord-317619-o7qfugjw 182 11 viral viral JJ cord-317619-o7qfugjw 182 12 infected infected JJ cord-317619-o7qfugjw 182 13 cells cell NNS cord-317619-o7qfugjw 182 14 from from IN cord-317619-o7qfugjw 182 15 fusing fuse VBG cord-317619-o7qfugjw 182 16 with with IN cord-317619-o7qfugjw 182 17 adjacent adjacent JJ cord-317619-o7qfugjw 182 18 cells cell NNS cord-317619-o7qfugjw 182 19 ( ( -LRB- cord-317619-o7qfugjw 182 20 122 122 CD cord-317619-o7qfugjw 182 21 ) ) -RRB- cord-317619-o7qfugjw 182 22 . . . cord-317619-o7qfugjw 183 1 Palivizumab Palivizumab NNP cord-317619-o7qfugjw 183 2 has have VBZ cord-317619-o7qfugjw 183 3 been be VBN cord-317619-o7qfugjw 183 4 shown show VBN cord-317619-o7qfugjw 183 5 to to TO cord-317619-o7qfugjw 183 6 be be VB cord-317619-o7qfugjw 183 7 most most RBS cord-317619-o7qfugjw 183 8 effective effective JJ cord-317619-o7qfugjw 183 9 in in IN cord-317619-o7qfugjw 183 10 high high JJ cord-317619-o7qfugjw 183 11 - - HYPH cord-317619-o7qfugjw 183 12 risk risk NN cord-317619-o7qfugjw 183 13 populations population NNS cord-317619-o7qfugjw 183 14 , , , cord-317619-o7qfugjw 183 15 specifically specifically RB cord-317619-o7qfugjw 183 16 premature premature JJ cord-317619-o7qfugjw 183 17 infants infant NNS cord-317619-o7qfugjw 183 18 and and CC cord-317619-o7qfugjw 183 19 those those DT cord-317619-o7qfugjw 183 20 with with IN cord-317619-o7qfugjw 183 21 chronic chronic JJ cord-317619-o7qfugjw 183 22 lung lung NN cord-317619-o7qfugjw 183 23 disease disease NN cord-317619-o7qfugjw 183 24 or or CC cord-317619-o7qfugjw 183 25 congenital congenital JJ cord-317619-o7qfugjw 183 26 heart heart NN cord-317619-o7qfugjw 183 27 disease disease NN cord-317619-o7qfugjw 183 28 ( ( -LRB- cord-317619-o7qfugjw 183 29 123 123 CD cord-317619-o7qfugjw 183 30 ) ) -RRB- cord-317619-o7qfugjw 183 31 . . . cord-317619-o7qfugjw 184 1 The the DT cord-317619-o7qfugjw 184 2 use use NN cord-317619-o7qfugjw 184 3 of of IN cord-317619-o7qfugjw 184 4 palivizumab palivizumab NNS cord-317619-o7qfugjw 184 5 as as IN cord-317619-o7qfugjw 184 6 treatment treatment NN cord-317619-o7qfugjw 184 7 for for IN cord-317619-o7qfugjw 184 8 RSV RSV NNP cord-317619-o7qfugjw 184 9 infection infection NN cord-317619-o7qfugjw 184 10 in in IN cord-317619-o7qfugjw 184 11 mechanically mechanically RB cord-317619-o7qfugjw 184 12 ventilated ventilate VBN cord-317619-o7qfugjw 184 13 pediatric pediatric JJ cord-317619-o7qfugjw 184 14 patients patient NNS cord-317619-o7qfugjw 184 15 has have VBZ cord-317619-o7qfugjw 184 16 not not RB cord-317619-o7qfugjw 184 17 been be VBN cord-317619-o7qfugjw 184 18 shown show VBN cord-317619-o7qfugjw 184 19 to to TO cord-317619-o7qfugjw 184 20 be be VB cord-317619-o7qfugjw 184 21 effective effective JJ cord-317619-o7qfugjw 184 22 ( ( -LRB- cord-317619-o7qfugjw 184 23 124 124 CD cord-317619-o7qfugjw 184 24 ) ) -RRB- cord-317619-o7qfugjw 184 25 . . . cord-317619-o7qfugjw 185 1 Furthermore furthermore RB cord-317619-o7qfugjw 185 2 , , , cord-317619-o7qfugjw 185 3 studies study NNS cord-317619-o7qfugjw 185 4 have have VBP cord-317619-o7qfugjw 185 5 also also RB cord-317619-o7qfugjw 185 6 shown show VBN cord-317619-o7qfugjw 185 7 that that WDT cord-317619-o7qfugjw 185 8 palivizumab palivizumab VBZ cord-317619-o7qfugjw 185 9 prophylaxis prophylaxis NN cord-317619-o7qfugjw 185 10 in in IN cord-317619-o7qfugjw 185 11 these these DT cord-317619-o7qfugjw 185 12 patients patient NNS cord-317619-o7qfugjw 185 13 has have VBZ cord-317619-o7qfugjw 185 14 a a DT cord-317619-o7qfugjw 185 15 limited limited JJ cord-317619-o7qfugjw 185 16 effect effect NN cord-317619-o7qfugjw 185 17 on on IN cord-317619-o7qfugjw 185 18 the the DT cord-317619-o7qfugjw 185 19 total total JJ cord-317619-o7qfugjw 185 20 disease disease NN cord-317619-o7qfugjw 185 21 burden burden NN cord-317619-o7qfugjw 185 22 of of IN cord-317619-o7qfugjw 185 23 RSV RSV NNP cord-317619-o7qfugjw 185 24 infection infection NN cord-317619-o7qfugjw 185 25 , , , cord-317619-o7qfugjw 185 26 including include VBG cord-317619-o7qfugjw 185 27 overall overall JJ cord-317619-o7qfugjw 185 28 RSV RSV NNP cord-317619-o7qfugjw 185 29 - - HYPH cord-317619-o7qfugjw 185 30 related relate VBN cord-317619-o7qfugjw 185 31 hospital hospital NN cord-317619-o7qfugjw 185 32 admissions admission NNS cord-317619-o7qfugjw 185 33 and and CC cord-317619-o7qfugjw 185 34 resource resource NN cord-317619-o7qfugjw 185 35 utilization utilization NN cord-317619-o7qfugjw 185 36 ( ( -LRB- cord-317619-o7qfugjw 185 37 12 12 CD cord-317619-o7qfugjw 185 38 , , , cord-317619-o7qfugjw 185 39 125 125 CD cord-317619-o7qfugjw 185 40 ) ) -RRB- cord-317619-o7qfugjw 185 41 . . . cord-317619-o7qfugjw 186 1 Although although IN cord-317619-o7qfugjw 186 2 not not RB cord-317619-o7qfugjw 186 3 approved approve VBN cord-317619-o7qfugjw 186 4 for for IN cord-317619-o7qfugjw 186 5 use use NN cord-317619-o7qfugjw 186 6 in in IN cord-317619-o7qfugjw 186 7 the the DT cord-317619-o7qfugjw 186 8 United United NNP cord-317619-o7qfugjw 186 9 States States NNP cord-317619-o7qfugjw 186 10 , , , cord-317619-o7qfugjw 186 11 motavizumab motavizumab NNP cord-317619-o7qfugjw 186 12 , , , cord-317619-o7qfugjw 186 13 the the DT cord-317619-o7qfugjw 186 14 second second JJ cord-317619-o7qfugjw 186 15 - - HYPH cord-317619-o7qfugjw 186 16 generation generation NN cord-317619-o7qfugjw 186 17 derivative derivative NN cord-317619-o7qfugjw 186 18 of of IN cord-317619-o7qfugjw 186 19 palivizumab palivizumab NNS cord-317619-o7qfugjw 186 20 , , , cord-317619-o7qfugjw 186 21 decreased decrease VBD cord-317619-o7qfugjw 186 22 viral viral JJ cord-317619-o7qfugjw 186 23 load load NN cord-317619-o7qfugjw 186 24 compared compare VBN cord-317619-o7qfugjw 186 25 with with IN cord-317619-o7qfugjw 186 26 placebo placebo NN cord-317619-o7qfugjw 186 27 ( ( -LRB- cord-317619-o7qfugjw 186 28 126 126 CD cord-317619-o7qfugjw 186 29 ) ) -RRB- cord-317619-o7qfugjw 186 30 . . . cord-317619-o7qfugjw 187 1 However however RB cord-317619-o7qfugjw 187 2 , , , cord-317619-o7qfugjw 187 3 in in IN cord-317619-o7qfugjw 187 4 a a DT cord-317619-o7qfugjw 187 5 more more RBR cord-317619-o7qfugjw 187 6 recent recent JJ cord-317619-o7qfugjw 187 7 study study NN cord-317619-o7qfugjw 187 8 of of IN cord-317619-o7qfugjw 187 9 hospitalized hospitalize VBN cord-317619-o7qfugjw 187 10 RSV RSV NNP cord-317619-o7qfugjw 187 11 infected infect VBN cord-317619-o7qfugjw 187 12 infants infant NNS cord-317619-o7qfugjw 187 13 treated treat VBN cord-317619-o7qfugjw 187 14 with with IN cord-317619-o7qfugjw 187 15 motavizumab motavizumab NNS cord-317619-o7qfugjw 187 16 or or CC cord-317619-o7qfugjw 187 17 placebo placebo NN cord-317619-o7qfugjw 187 18 , , , cord-317619-o7qfugjw 187 19 no no DT cord-317619-o7qfugjw 187 20 antiviral antiviral JJ cord-317619-o7qfugjw 187 21 effect effect NN cord-317619-o7qfugjw 187 22 was be VBD cord-317619-o7qfugjw 187 23 demonstrated demonstrate VBN cord-317619-o7qfugjw 187 24 ( ( -LRB- cord-317619-o7qfugjw 187 25 127 127 CD cord-317619-o7qfugjw 187 26 ) ) -RRB- cord-317619-o7qfugjw 187 27 . . . cord-317619-o7qfugjw 188 1 Furthermore furthermore RB cord-317619-o7qfugjw 188 2 , , , cord-317619-o7qfugjw 188 3 both both DT cord-317619-o7qfugjw 188 4 therapies therapy NNS cord-317619-o7qfugjw 188 5 produce produce VBP cord-317619-o7qfugjw 188 6 only only RB cord-317619-o7qfugjw 188 7 temporary temporary JJ cord-317619-o7qfugjw 188 8 , , , cord-317619-o7qfugjw 188 9 passive passive JJ cord-317619-o7qfugjw 188 10 immunity immunity NN cord-317619-o7qfugjw 188 11 ( ( -LRB- cord-317619-o7qfugjw 188 12 128 128 CD cord-317619-o7qfugjw 188 13 ) ) -RRB- cord-317619-o7qfugjw 188 14 . . . cord-317619-o7qfugjw 189 1 The the DT cord-317619-o7qfugjw 189 2 2009 2009 CD cord-317619-o7qfugjw 189 3 influenza influenza NN cord-317619-o7qfugjw 189 4 A a NN cord-317619-o7qfugjw 189 5 ( ( -LRB- cord-317619-o7qfugjw 189 6 H1N1 H1N1 NNP cord-317619-o7qfugjw 189 7 ) ) -RRB- cord-317619-o7qfugjw 189 8 virus virus NN cord-317619-o7qfugjw 189 9 was be VBD cord-317619-o7qfugjw 189 10 a a DT cord-317619-o7qfugjw 189 11 novel novel JJ cord-317619-o7qfugjw 189 12 strain strain NN cord-317619-o7qfugjw 189 13 , , , cord-317619-o7qfugjw 189 14 leaving leave VBG cord-317619-o7qfugjw 189 15 children child NNS cord-317619-o7qfugjw 189 16 and and CC cord-317619-o7qfugjw 189 17 young young JJ cord-317619-o7qfugjw 189 18 adults adult NNS cord-317619-o7qfugjw 189 19 with with IN cord-317619-o7qfugjw 189 20 little little JJ cord-317619-o7qfugjw 189 21 if if IN cord-317619-o7qfugjw 189 22 any any DT cord-317619-o7qfugjw 189 23 preexisting preexist VBG cord-317619-o7qfugjw 189 24 antibodies antibody NNS cord-317619-o7qfugjw 189 25 and and CC cord-317619-o7qfugjw 189 26 without without IN cord-317619-o7qfugjw 189 27 adequate adequate JJ cord-317619-o7qfugjw 189 28 protection protection NN cord-317619-o7qfugjw 189 29 with with IN cord-317619-o7qfugjw 189 30 the the DT cord-317619-o7qfugjw 189 31 seasonal seasonal JJ cord-317619-o7qfugjw 189 32 influenza influenza NN cord-317619-o7qfugjw 189 33 vaccine vaccine NN cord-317619-o7qfugjw 189 34 alone alone RB cord-317619-o7qfugjw 189 35 ( ( -LRB- cord-317619-o7qfugjw 189 36 129 129 CD cord-317619-o7qfugjw 189 37 ) ) -RRB- cord-317619-o7qfugjw 189 38 . . . cord-317619-o7qfugjw 190 1 A a DT cord-317619-o7qfugjw 190 2 new new JJ cord-317619-o7qfugjw 190 3 influenza influenza NN cord-317619-o7qfugjw 190 4 A a NN cord-317619-o7qfugjw 190 5 ( ( -LRB- cord-317619-o7qfugjw 190 6 H1N1 H1N1 NNP cord-317619-o7qfugjw 190 7 ) ) -RRB- cord-317619-o7qfugjw 190 8 virus virus NN cord-317619-o7qfugjw 190 9 vaccine vaccine NN cord-317619-o7qfugjw 190 10 was be VBD cord-317619-o7qfugjw 190 11 rapidly rapidly RB cord-317619-o7qfugjw 190 12 developed develop VBN cord-317619-o7qfugjw 190 13 and and CC cord-317619-o7qfugjw 190 14 has have VBZ cord-317619-o7qfugjw 190 15 subsequently subsequently RB cord-317619-o7qfugjw 190 16 been be VBN cord-317619-o7qfugjw 190 17 shown show VBN cord-317619-o7qfugjw 190 18 to to TO cord-317619-o7qfugjw 190 19 be be VB cord-317619-o7qfugjw 190 20 safe safe JJ cord-317619-o7qfugjw 190 21 and and CC cord-317619-o7qfugjw 190 22 effective effective JJ cord-317619-o7qfugjw 190 23 at at IN cord-317619-o7qfugjw 190 24 providing provide VBG cord-317619-o7qfugjw 190 25 adequate adequate JJ cord-317619-o7qfugjw 190 26 immunological immunological JJ cord-317619-o7qfugjw 190 27 response response NN cord-317619-o7qfugjw 190 28 ( ( -LRB- cord-317619-o7qfugjw 190 29 130 130 CD cord-317619-o7qfugjw 190 30 , , , cord-317619-o7qfugjw 190 31 131 131 CD cord-317619-o7qfugjw 190 32 ) ) -RRB- cord-317619-o7qfugjw 190 33 . . . cord-317619-o7qfugjw 191 1 One one CD cord-317619-o7qfugjw 191 2 post post JJ cord-317619-o7qfugjw 191 3 - - JJ cord-317619-o7qfugjw 191 4 pandemic pandemic JJ cord-317619-o7qfugjw 191 5 study study NN cord-317619-o7qfugjw 191 6 showed show VBD cord-317619-o7qfugjw 191 7 a a DT cord-317619-o7qfugjw 191 8 correlation correlation NN cord-317619-o7qfugjw 191 9 with with IN cord-317619-o7qfugjw 191 10 higher high JJR cord-317619-o7qfugjw 191 11 rates rate NNS cord-317619-o7qfugjw 191 12 of of IN cord-317619-o7qfugjw 191 13 influenza influenza NN cord-317619-o7qfugjw 191 14 A a NN cord-317619-o7qfugjw 191 15 ( ( -LRB- cord-317619-o7qfugjw 191 16 H1N1 H1N1 NNP cord-317619-o7qfugjw 191 17 ) ) -RRB- cord-317619-o7qfugjw 191 18 virus virus NN cord-317619-o7qfugjw 191 19 infection infection NN cord-317619-o7qfugjw 191 20 , , , cord-317619-o7qfugjw 191 21 compared compare VBN cord-317619-o7qfugjw 191 22 with with IN cord-317619-o7qfugjw 191 23 other other JJ cord-317619-o7qfugjw 191 24 influenza influenza NN cord-317619-o7qfugjw 191 25 types type NNS cord-317619-o7qfugjw 191 26 , , , cord-317619-o7qfugjw 191 27 along along IN cord-317619-o7qfugjw 191 28 with with IN cord-317619-o7qfugjw 191 29 increased increase VBN cord-317619-o7qfugjw 191 30 ICU ICU NNP cord-317619-o7qfugjw 191 31 admissions admission NNS cord-317619-o7qfugjw 191 32 for for IN cord-317619-o7qfugjw 191 33 countries country NNS cord-317619-o7qfugjw 191 34 with with IN cord-317619-o7qfugjw 191 35 limited limited JJ cord-317619-o7qfugjw 191 36 numbers number NNS cord-317619-o7qfugjw 191 37 of of IN cord-317619-o7qfugjw 191 38 the the DT cord-317619-o7qfugjw 191 39 population population NN cord-317619-o7qfugjw 191 40 having have VBG cord-317619-o7qfugjw 191 41 received receive VBN cord-317619-o7qfugjw 191 42 influenza influenza NN cord-317619-o7qfugjw 191 43 A a NN cord-317619-o7qfugjw 191 44 ( ( -LRB- cord-317619-o7qfugjw 191 45 H1N1 H1N1 NNP cord-317619-o7qfugjw 191 46 ) ) -RRB- cord-317619-o7qfugjw 191 47 virus virus NN cord-317619-o7qfugjw 191 48 vaccination vaccination NN cord-317619-o7qfugjw 191 49 ( ( -LRB- cord-317619-o7qfugjw 191 50 132 132 CD cord-317619-o7qfugjw 191 51 ) ) -RRB- cord-317619-o7qfugjw 191 52 . . . cord-317619-o7qfugjw 192 1 In in IN cord-317619-o7qfugjw 192 2 addition addition NN cord-317619-o7qfugjw 192 3 to to IN cord-317619-o7qfugjw 192 4 general general JJ cord-317619-o7qfugjw 192 5 supportive supportive JJ cord-317619-o7qfugjw 192 6 care care NN cord-317619-o7qfugjw 192 7 , , , cord-317619-o7qfugjw 192 8 the the DT cord-317619-o7qfugjw 192 9 second second JJ cord-317619-o7qfugjw 192 10 goal goal NN cord-317619-o7qfugjw 192 11 of of IN cord-317619-o7qfugjw 192 12 therapy therapy NN cord-317619-o7qfugjw 192 13 in in IN cord-317619-o7qfugjw 192 14 viral viral JJ cord-317619-o7qfugjw 192 15 infection infection NN cord-317619-o7qfugjw 192 16 focuses focus VBZ cord-317619-o7qfugjw 192 17 on on IN cord-317619-o7qfugjw 192 18 reducing reduce VBG cord-317619-o7qfugjw 192 19 the the DT cord-317619-o7qfugjw 192 20 infectious infectious JJ cord-317619-o7qfugjw 192 21 burden burden NN cord-317619-o7qfugjw 192 22 and and CC cord-317619-o7qfugjw 192 23 , , , cord-317619-o7qfugjw 192 24 theoretically theoretically RB cord-317619-o7qfugjw 192 25 , , , cord-317619-o7qfugjw 192 26 subsequent subsequent JJ cord-317619-o7qfugjw 192 27 viral viral JJ cord-317619-o7qfugjw 192 28 sequelae sequela NNS cord-317619-o7qfugjw 192 29 . . . cord-317619-o7qfugjw 193 1 Currently currently RB cord-317619-o7qfugjw 193 2 , , , cord-317619-o7qfugjw 193 3 inhaled inhale VBN cord-317619-o7qfugjw 193 4 ribavirin ribavirin RB cord-317619-o7qfugjw 193 5 is be VBZ cord-317619-o7qfugjw 193 6 the the DT cord-317619-o7qfugjw 193 7 only only RB cord-317619-o7qfugjw 193 8 approved approve VBN cord-317619-o7qfugjw 193 9 antiviral antiviral JJ cord-317619-o7qfugjw 193 10 treatment treatment NN cord-317619-o7qfugjw 193 11 for for IN cord-317619-o7qfugjw 193 12 RSV RSV NNP cord-317619-o7qfugjw 193 13 infection infection NN cord-317619-o7qfugjw 193 14 in in IN cord-317619-o7qfugjw 193 15 children child NNS cord-317619-o7qfugjw 193 16 ( ( -LRB- cord-317619-o7qfugjw 193 17 133 133 CD cord-317619-o7qfugjw 193 18 ) ) -RRB- cord-317619-o7qfugjw 193 19 but but CC cord-317619-o7qfugjw 193 20 its -PRON- PRP$ cord-317619-o7qfugjw 193 21 use use NN cord-317619-o7qfugjw 193 22 is be VBZ cord-317619-o7qfugjw 193 23 associated associate VBN cord-317619-o7qfugjw 193 24 with with IN cord-317619-o7qfugjw 193 25 potential potential JJ cord-317619-o7qfugjw 193 26 teratogenicity teratogenicity NN cord-317619-o7qfugjw 193 27 , , , cord-317619-o7qfugjw 193 28 and and CC cord-317619-o7qfugjw 193 29 its -PRON- PRP$ cord-317619-o7qfugjw 193 30 efficacy efficacy NN cord-317619-o7qfugjw 193 31 remains remain VBZ cord-317619-o7qfugjw 193 32 uncertain uncertain JJ cord-317619-o7qfugjw 193 33 ( ( -LRB- cord-317619-o7qfugjw 193 34 134 134 CD cord-317619-o7qfugjw 193 35 ) ) -RRB- cord-317619-o7qfugjw 193 36 . . . cord-317619-o7qfugjw 194 1 Ribavirin ribavirin RB cord-317619-o7qfugjw 194 2 directly directly RB cord-317619-o7qfugjw 194 3 and and CC cord-317619-o7qfugjw 194 4 indirectly indirectly RB cord-317619-o7qfugjw 194 5 inhibits inhibit VBZ cord-317619-o7qfugjw 194 6 replication replication NN cord-317619-o7qfugjw 194 7 of of IN cord-317619-o7qfugjw 194 8 both both CC cord-317619-o7qfugjw 194 9 DNA DNA NNP cord-317619-o7qfugjw 194 10 and and CC cord-317619-o7qfugjw 194 11 RNA RNA NNP cord-317619-o7qfugjw 194 12 viruses virus NNS cord-317619-o7qfugjw 194 13 , , , cord-317619-o7qfugjw 194 14 including include VBG cord-317619-o7qfugjw 194 15 RSV RSV NNP cord-317619-o7qfugjw 194 16 ( ( -LRB- cord-317619-o7qfugjw 194 17 135 135 CD cord-317619-o7qfugjw 194 18 ) ) -RRB- cord-317619-o7qfugjw 194 19 . . . cord-317619-o7qfugjw 195 1 Studies study NNS cord-317619-o7qfugjw 195 2 in in IN cord-317619-o7qfugjw 195 3 infants infant NNS cord-317619-o7qfugjw 195 4 found find VBD cord-317619-o7qfugjw 195 5 a a DT cord-317619-o7qfugjw 195 6 decrease decrease NN cord-317619-o7qfugjw 195 7 in in IN cord-317619-o7qfugjw 195 8 mortality mortality NN cord-317619-o7qfugjw 195 9 and and CC cord-317619-o7qfugjw 195 10 respiratory respiratory JJ cord-317619-o7qfugjw 195 11 deterioration deterioration NN cord-317619-o7qfugjw 195 12 , , , cord-317619-o7qfugjw 195 13 and and CC cord-317619-o7qfugjw 195 14 a a DT cord-317619-o7qfugjw 195 15 decrease decrease NN cord-317619-o7qfugjw 195 16 in in IN cord-317619-o7qfugjw 195 17 days day NNS cord-317619-o7qfugjw 195 18 of of IN cord-317619-o7qfugjw 195 19 hospitalization hospitalization NN cord-317619-o7qfugjw 195 20 and and CC cord-317619-o7qfugjw 195 21 days day NNS cord-317619-o7qfugjw 195 22 of of IN cord-317619-o7qfugjw 195 23 mechanical mechanical JJ cord-317619-o7qfugjw 195 24 ventilation ventilation NN cord-317619-o7qfugjw 195 25 in in IN cord-317619-o7qfugjw 195 26 ventilated ventilate VBN cord-317619-o7qfugjw 195 27 infants infant NNS cord-317619-o7qfugjw 195 28 ( ( -LRB- cord-317619-o7qfugjw 195 29 136 136 CD cord-317619-o7qfugjw 195 30 ) ) -RRB- cord-317619-o7qfugjw 195 31 . . . cord-317619-o7qfugjw 196 1 Luo Luo NNP cord-317619-o7qfugjw 196 2 et et NNP cord-317619-o7qfugjw 196 3 al al NNP cord-317619-o7qfugjw 196 4 . . NNP cord-317619-o7qfugjw 196 5 reported report VBD cord-317619-o7qfugjw 196 6 an an DT cord-317619-o7qfugjw 196 7 adult adult NN cord-317619-o7qfugjw 196 8 case case NN cord-317619-o7qfugjw 196 9 of of IN cord-317619-o7qfugjw 196 10 severe severe JJ cord-317619-o7qfugjw 196 11 RSV RSV NNP cord-317619-o7qfugjw 196 12 infection infection NN cord-317619-o7qfugjw 196 13 progressing progress VBG cord-317619-o7qfugjw 196 14 to to IN cord-317619-o7qfugjw 196 15 ARDS ARDS NNP cord-317619-o7qfugjw 196 16 that that WDT cord-317619-o7qfugjw 196 17 was be VBD cord-317619-o7qfugjw 196 18 successfully successfully RB cord-317619-o7qfugjw 196 19 treated treat VBN cord-317619-o7qfugjw 196 20 with with IN cord-317619-o7qfugjw 196 21 inhaled inhale VBN cord-317619-o7qfugjw 196 22 ribavirin ribavirin NN cord-317619-o7qfugjw 196 23 ( ( -LRB- cord-317619-o7qfugjw 196 24 137 137 CD cord-317619-o7qfugjw 196 25 ) ) -RRB- cord-317619-o7qfugjw 196 26 , , , cord-317619-o7qfugjw 196 27 but but CC cord-317619-o7qfugjw 196 28 overall overall JJ cord-317619-o7qfugjw 196 29 effectiveness effectiveness NN cord-317619-o7qfugjw 196 30 in in IN cord-317619-o7qfugjw 196 31 treatment treatment NN cord-317619-o7qfugjw 196 32 of of IN cord-317619-o7qfugjw 196 33 viral viral JJ cord-317619-o7qfugjw 196 34 pediatric pediatric JJ cord-317619-o7qfugjw 196 35 ARDS ARDS NNP cord-317619-o7qfugjw 196 36 has have VBZ cord-317619-o7qfugjw 196 37 yet yet RB cord-317619-o7qfugjw 196 38 to to TO cord-317619-o7qfugjw 196 39 be be VB cord-317619-o7qfugjw 196 40 determined determine VBN cord-317619-o7qfugjw 196 41 . . . cord-317619-o7qfugjw 197 1 In in IN cord-317619-o7qfugjw 197 2 addition addition NN cord-317619-o7qfugjw 197 3 to to IN cord-317619-o7qfugjw 197 4 its -PRON- PRP$ cord-317619-o7qfugjw 197 5 use use NN cord-317619-o7qfugjw 197 6 in in IN cord-317619-o7qfugjw 197 7 RSV RSV NNP cord-317619-o7qfugjw 197 8 , , , cord-317619-o7qfugjw 197 9 ribavirin ribavirin NN cord-317619-o7qfugjw 197 10 has have VBZ cord-317619-o7qfugjw 197 11 also also RB cord-317619-o7qfugjw 197 12 been be VBN cord-317619-o7qfugjw 197 13 used use VBN cord-317619-o7qfugjw 197 14 in in IN cord-317619-o7qfugjw 197 15 treatment treatment NN cord-317619-o7qfugjw 197 16 of of IN cord-317619-o7qfugjw 197 17 severe severe JJ cord-317619-o7qfugjw 197 18 influenza influenza NN cord-317619-o7qfugjw 197 19 A a NN cord-317619-o7qfugjw 197 20 ( ( -LRB- cord-317619-o7qfugjw 197 21 H1N1 H1N1 NNP cord-317619-o7qfugjw 197 22 ) ) -RRB- cord-317619-o7qfugjw 197 23 virus virus NN cord-317619-o7qfugjw 197 24 infection infection NN cord-317619-o7qfugjw 197 25 ( ( -LRB- cord-317619-o7qfugjw 197 26 138 138 CD cord-317619-o7qfugjw 197 27 ) ) -RRB- cord-317619-o7qfugjw 197 28 . . . cord-317619-o7qfugjw 198 1 Ribavirin ribavirin NN cord-317619-o7qfugjw 198 2 can can MD cord-317619-o7qfugjw 198 3 be be VB cord-317619-o7qfugjw 198 4 given give VBN cord-317619-o7qfugjw 198 5 orally orally RB cord-317619-o7qfugjw 198 6 but but CC cord-317619-o7qfugjw 198 7 is be VBZ cord-317619-o7qfugjw 198 8 typically typically RB cord-317619-o7qfugjw 198 9 aerosolized aerosolize VBN cord-317619-o7qfugjw 198 10 when when WRB cord-317619-o7qfugjw 198 11 used use VBN cord-317619-o7qfugjw 198 12 for for IN cord-317619-o7qfugjw 198 13 respiratory respiratory JJ cord-317619-o7qfugjw 198 14 viral viral JJ cord-317619-o7qfugjw 198 15 infections infection NNS cord-317619-o7qfugjw 198 16 . . . cord-317619-o7qfugjw 199 1 However however RB cord-317619-o7qfugjw 199 2 , , , cord-317619-o7qfugjw 199 3 safety safety NN cord-317619-o7qfugjw 199 4 considerations consideration NNS cord-317619-o7qfugjw 199 5 regarding regard VBG cord-317619-o7qfugjw 199 6 potential potential JJ cord-317619-o7qfugjw 199 7 teratogenicity teratogenicity NN cord-317619-o7qfugjw 199 8 and and CC cord-317619-o7qfugjw 199 9 exposure exposure NN cord-317619-o7qfugjw 199 10 to to IN cord-317619-o7qfugjw 199 11 health health NN cord-317619-o7qfugjw 199 12 - - HYPH cord-317619-o7qfugjw 199 13 care care NN cord-317619-o7qfugjw 199 14 workers worker NNS cord-317619-o7qfugjw 199 15 during during IN cord-317619-o7qfugjw 199 16 administration administration NN cord-317619-o7qfugjw 199 17 ( ( -LRB- cord-317619-o7qfugjw 199 18 134 134 CD cord-317619-o7qfugjw 199 19 ) ) -RRB- cord-317619-o7qfugjw 199 20 limit limit VB cord-317619-o7qfugjw 199 21 its -PRON- PRP$ cord-317619-o7qfugjw 199 22 use use NN cord-317619-o7qfugjw 199 23 . . . cord-317619-o7qfugjw 200 1 The the DT cord-317619-o7qfugjw 200 2 American American NNP cord-317619-o7qfugjw 200 3 Academy Academy NNP cord-317619-o7qfugjw 200 4 of of IN cord-317619-o7qfugjw 200 5 Pediatrics Pediatrics NNP cord-317619-o7qfugjw 200 6 does do VBZ cord-317619-o7qfugjw 200 7 not not RB cord-317619-o7qfugjw 200 8 recommend recommend VB cord-317619-o7qfugjw 200 9 the the DT cord-317619-o7qfugjw 200 10 routine routine JJ cord-317619-o7qfugjw 200 11 use use NN cord-317619-o7qfugjw 200 12 of of IN cord-317619-o7qfugjw 200 13 ribavirin ribavirin NN cord-317619-o7qfugjw 200 14 to to TO cord-317619-o7qfugjw 200 15 treat treat VB cord-317619-o7qfugjw 200 16 RSV RSV NNP cord-317619-o7qfugjw 200 17 infection infection NN cord-317619-o7qfugjw 200 18 , , , cord-317619-o7qfugjw 200 19 reserving reserve VBG cord-317619-o7qfugjw 200 20 its -PRON- PRP$ cord-317619-o7qfugjw 200 21 use use NN cord-317619-o7qfugjw 200 22 for for IN cord-317619-o7qfugjw 200 23 patients patient NNS cord-317619-o7qfugjw 200 24 with with IN cord-317619-o7qfugjw 200 25 potentially potentially RB cord-317619-o7qfugjw 200 26 life life NN cord-317619-o7qfugjw 200 27 - - HYPH cord-317619-o7qfugjw 200 28 threatening threaten VBG cord-317619-o7qfugjw 200 29 disease disease NN cord-317619-o7qfugjw 200 30 ( ( -LRB- cord-317619-o7qfugjw 200 31 139 139 CD cord-317619-o7qfugjw 200 32 ) ) -RRB- cord-317619-o7qfugjw 200 33 . . . cord-317619-o7qfugjw 201 1 Several several JJ cord-317619-o7qfugjw 201 2 small small JJ cord-317619-o7qfugjw 201 3 molecule molecule NN cord-317619-o7qfugjw 201 4 inhibitors inhibitor NNS cord-317619-o7qfugjw 201 5 that that WDT cord-317619-o7qfugjw 201 6 interfere interfere VBP cord-317619-o7qfugjw 201 7 with with IN cord-317619-o7qfugjw 201 8 RSV RSV NNP cord-317619-o7qfugjw 201 9 F F NNP cord-317619-o7qfugjw 201 10 protein protein NN cord-317619-o7qfugjw 201 11 ( ( -LRB- cord-317619-o7qfugjw 201 12 MDT-637 MDT-637 NNP cord-317619-o7qfugjw 201 13 and and CC cord-317619-o7qfugjw 201 14 JNJ-2408068 JNJ-2408068 NNP cord-317619-o7qfugjw 201 15 ) ) -RRB- cord-317619-o7qfugjw 201 16 ( ( -LRB- cord-317619-o7qfugjw 201 17 140 140 CD cord-317619-o7qfugjw 201 18 ) ) -RRB- cord-317619-o7qfugjw 201 19 including include VBG cord-317619-o7qfugjw 201 20 the the DT cord-317619-o7qfugjw 201 21 GS-5806 gs-5806 NN cord-317619-o7qfugjw 201 22 that that WDT cord-317619-o7qfugjw 201 23 was be VBD cord-317619-o7qfugjw 201 24 recently recently RB cord-317619-o7qfugjw 201 25 evaluated evaluate VBN cord-317619-o7qfugjw 201 26 in in IN cord-317619-o7qfugjw 201 27 a a DT cord-317619-o7qfugjw 201 28 challenge challenge NN cord-317619-o7qfugjw 201 29 safety safety NN cord-317619-o7qfugjw 201 30 study study NN cord-317619-o7qfugjw 201 31 of of IN cord-317619-o7qfugjw 201 32 healthy healthy JJ cord-317619-o7qfugjw 201 33 adults adult NNS cord-317619-o7qfugjw 201 34 ( ( -LRB- cord-317619-o7qfugjw 201 35 141 141 CD cord-317619-o7qfugjw 201 36 ) ) -RRB- cord-317619-o7qfugjw 201 37 . . . cord-317619-o7qfugjw 202 1 In in IN cord-317619-o7qfugjw 202 2 this this DT cord-317619-o7qfugjw 202 3 study study NN cord-317619-o7qfugjw 202 4 by by IN cord-317619-o7qfugjw 202 5 DeVincenzo DeVincenzo NNP cord-317619-o7qfugjw 202 6 et et NNP cord-317619-o7qfugjw 202 7 al al NNP cord-317619-o7qfugjw 202 8 . . . cord-317619-o7qfugjw 203 1 , , , cord-317619-o7qfugjw 203 2 treatment treatment NN cord-317619-o7qfugjw 203 3 resulted result VBD cord-317619-o7qfugjw 203 4 in in IN cord-317619-o7qfugjw 203 5 decreased decrease VBN cord-317619-o7qfugjw 203 6 viral viral JJ cord-317619-o7qfugjw 203 7 burden burden NN cord-317619-o7qfugjw 203 8 and and CC cord-317619-o7qfugjw 203 9 severity severity NN cord-317619-o7qfugjw 203 10 of of IN cord-317619-o7qfugjw 203 11 clinical clinical JJ cord-317619-o7qfugjw 203 12 disease disease NN cord-317619-o7qfugjw 203 13 . . . cord-317619-o7qfugjw 204 1 The the DT cord-317619-o7qfugjw 204 2 use use NN cord-317619-o7qfugjw 204 3 of of IN cord-317619-o7qfugjw 204 4 these these DT cord-317619-o7qfugjw 204 5 small small JJ cord-317619-o7qfugjw 204 6 molecule molecule NN cord-317619-o7qfugjw 204 7 inhibitors inhibitor NNS cord-317619-o7qfugjw 204 8 in in IN cord-317619-o7qfugjw 204 9 the the DT cord-317619-o7qfugjw 204 10 context context NN cord-317619-o7qfugjw 204 11 of of IN cord-317619-o7qfugjw 204 12 pediatric pediatric JJ cord-317619-o7qfugjw 204 13 subjects subject NNS cord-317619-o7qfugjw 204 14 who who WP cord-317619-o7qfugjw 204 15 develop develop VBP cord-317619-o7qfugjw 204 16 ARDS ARDS NNP cord-317619-o7qfugjw 204 17 remains remain VBZ cord-317619-o7qfugjw 204 18 untested untested JJ cord-317619-o7qfugjw 204 19 at at IN cord-317619-o7qfugjw 204 20 this this DT cord-317619-o7qfugjw 204 21 point point NN cord-317619-o7qfugjw 204 22 . . . cord-317619-o7qfugjw 205 1 Neuraminidase Neuraminidase NNP cord-317619-o7qfugjw 205 2 inhibitors inhibitor NNS cord-317619-o7qfugjw 205 3 ( ( -LRB- cord-317619-o7qfugjw 205 4 which which WDT cord-317619-o7qfugjw 205 5 prevent prevent VBP cord-317619-o7qfugjw 205 6 the the DT cord-317619-o7qfugjw 205 7 release release NN cord-317619-o7qfugjw 205 8 of of IN cord-317619-o7qfugjw 205 9 influenza influenza NN cord-317619-o7qfugjw 205 10 virions virion NNS cord-317619-o7qfugjw 205 11 ) ) -RRB- cord-317619-o7qfugjw 205 12 , , , cord-317619-o7qfugjw 205 13 including include VBG cord-317619-o7qfugjw 205 14 oral oral JJ cord-317619-o7qfugjw 205 15 oseltamivir oseltamivir NNS cord-317619-o7qfugjw 205 16 , , , cord-317619-o7qfugjw 205 17 inhaled inhale VBN cord-317619-o7qfugjw 205 18 zanamivir zanamivir NNP cord-317619-o7qfugjw 205 19 and and CC cord-317619-o7qfugjw 205 20 laninamivir laninamivir NNP cord-317619-o7qfugjw 205 21 , , , cord-317619-o7qfugjw 205 22 and and CC cord-317619-o7qfugjw 205 23 parenteral parenteral JJ cord-317619-o7qfugjw 205 24 peramivir peramivir NNS cord-317619-o7qfugjw 205 25 , , , cord-317619-o7qfugjw 205 26 remain remain VBP cord-317619-o7qfugjw 205 27 first first JJ cord-317619-o7qfugjw 205 28 - - HYPH cord-317619-o7qfugjw 205 29 line line NN cord-317619-o7qfugjw 205 30 interventions intervention NNS cord-317619-o7qfugjw 205 31 for for IN cord-317619-o7qfugjw 205 32 influenza influenza NN cord-317619-o7qfugjw 205 33 . . . cord-317619-o7qfugjw 206 1 Only only RB cord-317619-o7qfugjw 206 2 oseltamivir oseltamivir NN cord-317619-o7qfugjw 206 3 , , , cord-317619-o7qfugjw 206 4 peramivir peramivir NNS cord-317619-o7qfugjw 206 5 , , , cord-317619-o7qfugjw 206 6 and and CC cord-317619-o7qfugjw 206 7 zanamivir zanamivir NNP cord-317619-o7qfugjw 206 8 are be VBP cord-317619-o7qfugjw 206 9 available available JJ cord-317619-o7qfugjw 206 10 in in IN cord-317619-o7qfugjw 206 11 the the DT cord-317619-o7qfugjw 206 12 United United NNP cord-317619-o7qfugjw 206 13 States States NNP cord-317619-o7qfugjw 206 14 . . . cord-317619-o7qfugjw 207 1 Perhaps perhaps RB cord-317619-o7qfugjw 207 2 the the DT cord-317619-o7qfugjw 207 3 most most RBS cord-317619-o7qfugjw 207 4 widely widely RB cord-317619-o7qfugjw 207 5 used use VBN cord-317619-o7qfugjw 207 6 , , , cord-317619-o7qfugjw 207 7 oseltamivir oseltamivir NN cord-317619-o7qfugjw 207 8 results result VBZ cord-317619-o7qfugjw 207 9 in in IN cord-317619-o7qfugjw 207 10 a a DT cord-317619-o7qfugjw 207 11 significant significant JJ cord-317619-o7qfugjw 207 12 decrease decrease NN cord-317619-o7qfugjw 207 13 in in IN cord-317619-o7qfugjw 207 14 duration duration NN cord-317619-o7qfugjw 207 15 of of IN cord-317619-o7qfugjw 207 16 symptoms symptom NNS cord-317619-o7qfugjw 207 17 as as RB cord-317619-o7qfugjw 207 18 well well RB cord-317619-o7qfugjw 207 19 as as IN cord-317619-o7qfugjw 207 20 severity severity NN cord-317619-o7qfugjw 207 21 of of IN cord-317619-o7qfugjw 207 22 illness illness NN cord-317619-o7qfugjw 207 23 with with IN cord-317619-o7qfugjw 207 24 early early JJ cord-317619-o7qfugjw 207 25 treatment treatment NN cord-317619-o7qfugjw 207 26 ( ( -LRB- cord-317619-o7qfugjw 207 27 < < NN cord-317619-o7qfugjw 207 28 48 48 CD cord-317619-o7qfugjw 207 29 h h NN cord-317619-o7qfugjw 207 30 of of IN cord-317619-o7qfugjw 207 31 symptoms symptom NNS cord-317619-o7qfugjw 207 32 ) ) -RRB- cord-317619-o7qfugjw 207 33 ( ( -LRB- cord-317619-o7qfugjw 207 34 142 142 CD cord-317619-o7qfugjw 207 35 ) ) -RRB- cord-317619-o7qfugjw 207 36 . . . cord-317619-o7qfugjw 208 1 Use Use NNP cord-317619-o7qfugjw 208 2 of of IN cord-317619-o7qfugjw 208 3 oseltamivir oseltamivir NN cord-317619-o7qfugjw 208 4 in in IN cord-317619-o7qfugjw 208 5 severe severe JJ cord-317619-o7qfugjw 208 6 cases case NNS cord-317619-o7qfugjw 208 7 of of IN cord-317619-o7qfugjw 208 8 influenza influenza NN cord-317619-o7qfugjw 208 9 A a NN cord-317619-o7qfugjw 208 10 ( ( -LRB- cord-317619-o7qfugjw 208 11 H1N1 H1N1 NNP cord-317619-o7qfugjw 208 12 ) ) -RRB- cord-317619-o7qfugjw 208 13 has have VBZ cord-317619-o7qfugjw 208 14 become become VBN cord-317619-o7qfugjw 208 15 standard standard JJ cord-317619-o7qfugjw 208 16 practice practice NN cord-317619-o7qfugjw 208 17 ( ( -LRB- cord-317619-o7qfugjw 208 18 24 24 CD cord-317619-o7qfugjw 208 19 , , , cord-317619-o7qfugjw 208 20 143 143 CD cord-317619-o7qfugjw 208 21 ) ) -RRB- cord-317619-o7qfugjw 208 22 , , , cord-317619-o7qfugjw 208 23 although although IN cord-317619-o7qfugjw 208 24 some some DT cord-317619-o7qfugjw 208 25 studies study NNS cord-317619-o7qfugjw 208 26 have have VBP cord-317619-o7qfugjw 208 27 shown show VBN cord-317619-o7qfugjw 208 28 increased increase VBN cord-317619-o7qfugjw 208 29 resistance resistance NN cord-317619-o7qfugjw 208 30 ( ( -LRB- cord-317619-o7qfugjw 208 31 144 144 CD cord-317619-o7qfugjw 208 32 ) ) -RRB- cord-317619-o7qfugjw 208 33 . . . cord-317619-o7qfugjw 209 1 Randolph Randolph NNP cord-317619-o7qfugjw 209 2 et et NNP cord-317619-o7qfugjw 209 3 al al NNP cord-317619-o7qfugjw 209 4 . . NNP cord-317619-o7qfugjw 209 5 conducted conduct VBD cord-317619-o7qfugjw 209 6 a a DT cord-317619-o7qfugjw 209 7 retrospective retrospective JJ cord-317619-o7qfugjw 209 8 study study NN cord-317619-o7qfugjw 209 9 of of IN cord-317619-o7qfugjw 209 10 838 838 CD cord-317619-o7qfugjw 209 11 children child NNS cord-317619-o7qfugjw 209 12 admitted admit VBN cord-317619-o7qfugjw 209 13 to to IN cord-317619-o7qfugjw 209 14 the the DT cord-317619-o7qfugjw 209 15 PICU PICU NNP cord-317619-o7qfugjw 209 16 with with IN cord-317619-o7qfugjw 209 17 confirmed confirm VBN cord-317619-o7qfugjw 209 18 influenza influenza NN cord-317619-o7qfugjw 209 19 A a NN cord-317619-o7qfugjw 209 20 ( ( -LRB- cord-317619-o7qfugjw 209 21 H1N1 H1N1 NNP cord-317619-o7qfugjw 209 22 ) ) -RRB- cord-317619-o7qfugjw 209 23 infection infection NN cord-317619-o7qfugjw 209 24 ( ( -LRB- cord-317619-o7qfugjw 209 25 145 145 CD cord-317619-o7qfugjw 209 26 ) ) -RRB- cord-317619-o7qfugjw 209 27 . . . cord-317619-o7qfugjw 210 1 Overall overall RB cord-317619-o7qfugjw 210 2 , , , cord-317619-o7qfugjw 210 3 564 564 CD cord-317619-o7qfugjw 210 4 ( ( -LRB- cord-317619-o7qfugjw 210 5 67.3 67.3 CD cord-317619-o7qfugjw 210 6 % % NN cord-317619-o7qfugjw 210 7 ) ) -RRB- cord-317619-o7qfugjw 210 8 required require VBN cord-317619-o7qfugjw 210 9 mechanical mechanical JJ cord-317619-o7qfugjw 210 10 ventilation ventilation NN cord-317619-o7qfugjw 210 11 , , , cord-317619-o7qfugjw 210 12 but but CC cord-317619-o7qfugjw 210 13 the the DT cord-317619-o7qfugjw 210 14 rate rate NN cord-317619-o7qfugjw 210 15 of of IN cord-317619-o7qfugjw 210 16 progression progression NN cord-317619-o7qfugjw 210 17 to to IN cord-317619-o7qfugjw 210 18 ARDS ARDS NNP cord-317619-o7qfugjw 210 19 was be VBD cord-317619-o7qfugjw 210 20 not not RB cord-317619-o7qfugjw 210 21 reported report VBN cord-317619-o7qfugjw 210 22 . . . cord-317619-o7qfugjw 211 1 Although although IN cord-317619-o7qfugjw 211 2 88 88 CD cord-317619-o7qfugjw 211 3 % % NN cord-317619-o7qfugjw 211 4 were be VBD cord-317619-o7qfugjw 211 5 treated treat VBN cord-317619-o7qfugjw 211 6 with with IN cord-317619-o7qfugjw 211 7 oseltamivir oseltamivir NNP cord-317619-o7qfugjw 211 8 , , , cord-317619-o7qfugjw 211 9 there there EX cord-317619-o7qfugjw 211 10 was be VBD cord-317619-o7qfugjw 211 11 no no DT cord-317619-o7qfugjw 211 12 association association NN cord-317619-o7qfugjw 211 13 with with IN cord-317619-o7qfugjw 211 14 improved improved JJ cord-317619-o7qfugjw 211 15 mortality mortality NN cord-317619-o7qfugjw 211 16 . . . cord-317619-o7qfugjw 212 1 Farias Farias NNP cord-317619-o7qfugjw 212 2 et et NNP cord-317619-o7qfugjw 212 3 al al NNP cord-317619-o7qfugjw 212 4 . . . cord-317619-o7qfugjw 213 1 found find VBD cord-317619-o7qfugjw 213 2 a a DT cord-317619-o7qfugjw 213 3 reduced reduce VBN cord-317619-o7qfugjw 213 4 mortality mortality NN cord-317619-o7qfugjw 213 5 in in IN cord-317619-o7qfugjw 213 6 patients patient NNS cord-317619-o7qfugjw 213 7 with with IN cord-317619-o7qfugjw 213 8 PARDS PARDS NNP cord-317619-o7qfugjw 213 9 from from IN cord-317619-o7qfugjw 213 10 influenza influenza NN cord-317619-o7qfugjw 213 11 A A NNP cord-317619-o7qfugjw 213 12 ( ( -LRB- cord-317619-o7qfugjw 213 13 H1N1 H1N1 NNP cord-317619-o7qfugjw 213 14 ) ) -RRB- cord-317619-o7qfugjw 213 15 if if IN cord-317619-o7qfugjw 213 16 oseltamivir oseltamivir NNP cord-317619-o7qfugjw 213 17 was be VBD cord-317619-o7qfugjw 213 18 administered administer VBN cord-317619-o7qfugjw 213 19 within within IN cord-317619-o7qfugjw 213 20 the the DT cord-317619-o7qfugjw 213 21 first first JJ cord-317619-o7qfugjw 213 22 24 24 CD cord-317619-o7qfugjw 213 23 h h NN cord-317619-o7qfugjw 213 24 ( ( -LRB- cord-317619-o7qfugjw 213 25 25 25 CD cord-317619-o7qfugjw 213 26 ) ) -RRB- cord-317619-o7qfugjw 213 27 . . . cord-317619-o7qfugjw 214 1 While while IN cord-317619-o7qfugjw 214 2 further further JJ cord-317619-o7qfugjw 214 3 studies study NNS cord-317619-o7qfugjw 214 4 are be VBP cord-317619-o7qfugjw 214 5 needed need VBN cord-317619-o7qfugjw 214 6 to to TO cord-317619-o7qfugjw 214 7 look look VB cord-317619-o7qfugjw 214 8 at at IN cord-317619-o7qfugjw 214 9 the the DT cord-317619-o7qfugjw 214 10 effectiveness effectiveness NN cord-317619-o7qfugjw 214 11 of of IN cord-317619-o7qfugjw 214 12 antiviral antiviral JJ cord-317619-o7qfugjw 214 13 medications medication NNS cord-317619-o7qfugjw 214 14 in in IN cord-317619-o7qfugjw 214 15 the the DT cord-317619-o7qfugjw 214 16 treatment treatment NN cord-317619-o7qfugjw 214 17 of of IN cord-317619-o7qfugjw 214 18 viral viral RB cord-317619-o7qfugjw 214 19 - - HYPH cord-317619-o7qfugjw 214 20 induced induce VBN cord-317619-o7qfugjw 214 21 ARDS ARDS NNP cord-317619-o7qfugjw 214 22 , , , cord-317619-o7qfugjw 214 23 in in IN cord-317619-o7qfugjw 214 24 recent recent JJ cord-317619-o7qfugjw 214 25 years year NNS cord-317619-o7qfugjw 214 26 , , , cord-317619-o7qfugjw 214 27 investigators investigator NNS cord-317619-o7qfugjw 214 28 are be VBP cord-317619-o7qfugjw 214 29 also also RB cord-317619-o7qfugjw 214 30 focusing focus VBG cord-317619-o7qfugjw 214 31 on on IN cord-317619-o7qfugjw 214 32 the the DT cord-317619-o7qfugjw 214 33 potential potential JJ cord-317619-o7qfugjw 214 34 benefits benefit NNS cord-317619-o7qfugjw 214 35 of of IN cord-317619-o7qfugjw 214 36 immune immune JJ cord-317619-o7qfugjw 214 37 modulation modulation NN cord-317619-o7qfugjw 214 38 . . . cord-317619-o7qfugjw 215 1 With with IN cord-317619-o7qfugjw 215 2 enhancement enhancement NN cord-317619-o7qfugjw 215 3 in in IN cord-317619-o7qfugjw 215 4 research research NN cord-317619-o7qfugjw 215 5 surrounding surround VBG cord-317619-o7qfugjw 215 6 viral viral JJ cord-317619-o7qfugjw 215 7 pathogenicity pathogenicity NN cord-317619-o7qfugjw 215 8 and and CC cord-317619-o7qfugjw 215 9 host host NN cord-317619-o7qfugjw 215 10 immune immune JJ cord-317619-o7qfugjw 215 11 response response NN cord-317619-o7qfugjw 215 12 , , , cord-317619-o7qfugjw 215 13 potential potential JJ cord-317619-o7qfugjw 215 14 targets target NNS cord-317619-o7qfugjw 215 15 of of IN cord-317619-o7qfugjw 215 16 intervention intervention NN cord-317619-o7qfugjw 215 17 will will MD cord-317619-o7qfugjw 215 18 hopefully hopefully RB cord-317619-o7qfugjw 215 19 be be VB cord-317619-o7qfugjw 215 20 identified identify VBN cord-317619-o7qfugjw 215 21 . . . cord-317619-o7qfugjw 216 1 Aside aside RB cord-317619-o7qfugjw 216 2 from from IN cord-317619-o7qfugjw 216 3 viral viral JJ cord-317619-o7qfugjw 216 4 - - HYPH cord-317619-o7qfugjw 216 5 specific specific JJ cord-317619-o7qfugjw 216 6 therapies therapy NNS cord-317619-o7qfugjw 216 7 , , , cord-317619-o7qfugjw 216 8 ECMO ECMO NNP cord-317619-o7qfugjw 216 9 has have VBZ cord-317619-o7qfugjw 216 10 been be VBN cord-317619-o7qfugjw 216 11 utilized utilize VBN cord-317619-o7qfugjw 216 12 as as IN cord-317619-o7qfugjw 216 13 rescue rescue NN cord-317619-o7qfugjw 216 14 therapy therapy NN cord-317619-o7qfugjw 216 15 for for IN cord-317619-o7qfugjw 216 16 severe severe JJ cord-317619-o7qfugjw 216 17 respiratory respiratory JJ cord-317619-o7qfugjw 216 18 failure failure NN cord-317619-o7qfugjw 216 19 in in IN cord-317619-o7qfugjw 216 20 pediatrics pediatric NNS cord-317619-o7qfugjw 216 21 for for IN cord-317619-o7qfugjw 216 22 more more JJR cord-317619-o7qfugjw 216 23 than than IN cord-317619-o7qfugjw 216 24 20 20 CD cord-317619-o7qfugjw 216 25 years year NNS cord-317619-o7qfugjw 216 26 , , , cord-317619-o7qfugjw 216 27 with with IN cord-317619-o7qfugjw 216 28 more more JJR cord-317619-o7qfugjw 216 29 than than IN cord-317619-o7qfugjw 216 30 50 50 CD cord-317619-o7qfugjw 216 31 % % NN cord-317619-o7qfugjw 216 32 survival survival NN cord-317619-o7qfugjw 216 33 ( ( -LRB- cord-317619-o7qfugjw 216 34 146 146 CD cord-317619-o7qfugjw 216 35 ) ) -RRB- cord-317619-o7qfugjw 216 36 . . . cord-317619-o7qfugjw 217 1 The the DT cord-317619-o7qfugjw 217 2 overall overall JJ cord-317619-o7qfugjw 217 3 use use NN cord-317619-o7qfugjw 217 4 of of IN cord-317619-o7qfugjw 217 5 ECMO ECMO NNP cord-317619-o7qfugjw 217 6 for for IN cord-317619-o7qfugjw 217 7 treatment treatment NN cord-317619-o7qfugjw 217 8 of of IN cord-317619-o7qfugjw 217 9 ARDS ARDS NNP cord-317619-o7qfugjw 217 10 has have VBZ cord-317619-o7qfugjw 217 11 increased increase VBN cord-317619-o7qfugjw 217 12 with with IN cord-317619-o7qfugjw 217 13 improvement improvement NN cord-317619-o7qfugjw 217 14 in in IN cord-317619-o7qfugjw 217 15 mortality mortality NN cord-317619-o7qfugjw 217 16 ( ( -LRB- cord-317619-o7qfugjw 217 17 147 147 CD cord-317619-o7qfugjw 217 18 ) ) -RRB- cord-317619-o7qfugjw 217 19 . . . cord-317619-o7qfugjw 218 1 The the DT cord-317619-o7qfugjw 218 2 recent recent JJ cord-317619-o7qfugjw 218 3 PALICC PALICC NNP cord-317619-o7qfugjw 218 4 recommendations recommendation NNS cord-317619-o7qfugjw 218 5 conclude conclude VBP cord-317619-o7qfugjw 218 6 that that IN cord-317619-o7qfugjw 218 7 ECMO ECMO NNP cord-317619-o7qfugjw 218 8 should should MD cord-317619-o7qfugjw 218 9 be be VB cord-317619-o7qfugjw 218 10 considered consider VBN cord-317619-o7qfugjw 218 11 for for IN cord-317619-o7qfugjw 218 12 treatment treatment NN cord-317619-o7qfugjw 218 13 of of IN cord-317619-o7qfugjw 218 14 pARDS pARDS NNP cord-317619-o7qfugjw 219 1 when when WRB cord-317619-o7qfugjw 219 2 lung lung NN cord-317619-o7qfugjw 219 3 - - HYPH cord-317619-o7qfugjw 219 4 protective protective JJ cord-317619-o7qfugjw 219 5 strategies strategy NNS cord-317619-o7qfugjw 219 6 have have VBP cord-317619-o7qfugjw 219 7 failed fail VBN cord-317619-o7qfugjw 219 8 , , , cord-317619-o7qfugjw 219 9 when when WRB cord-317619-o7qfugjw 219 10 the the DT cord-317619-o7qfugjw 219 11 cause cause NN cord-317619-o7qfugjw 219 12 of of IN cord-317619-o7qfugjw 219 13 respiratory respiratory JJ cord-317619-o7qfugjw 219 14 failure failure NN cord-317619-o7qfugjw 219 15 is be VBZ cord-317619-o7qfugjw 219 16 thought think VBN cord-317619-o7qfugjw 219 17 to to TO cord-317619-o7qfugjw 219 18 be be VB cord-317619-o7qfugjw 219 19 reversible reversible JJ cord-317619-o7qfugjw 219 20 , , , cord-317619-o7qfugjw 219 21 or or CC cord-317619-o7qfugjw 219 22 when when WRB cord-317619-o7qfugjw 219 23 the the DT cord-317619-o7qfugjw 219 24 child child NN cord-317619-o7qfugjw 219 25 may may MD cord-317619-o7qfugjw 219 26 be be VB cord-317619-o7qfugjw 219 27 suitable suitable JJ cord-317619-o7qfugjw 219 28 for for IN cord-317619-o7qfugjw 219 29 lung lung NN cord-317619-o7qfugjw 219 30 transplantation transplantation NN cord-317619-o7qfugjw 219 31 ( ( -LRB- cord-317619-o7qfugjw 219 32 148 148 CD cord-317619-o7qfugjw 219 33 ) ) -RRB- cord-317619-o7qfugjw 219 34 . . . cord-317619-o7qfugjw 220 1 The the DT cord-317619-o7qfugjw 220 2 use use NN cord-317619-o7qfugjw 220 3 of of IN cord-317619-o7qfugjw 220 4 ECMO ECMO NNP cord-317619-o7qfugjw 220 5 in in IN cord-317619-o7qfugjw 220 6 pediatric pediatric JJ cord-317619-o7qfugjw 220 7 respiratory respiratory JJ cord-317619-o7qfugjw 220 8 failure failure NN cord-317619-o7qfugjw 220 9 due due JJ cord-317619-o7qfugjw 220 10 to to IN cord-317619-o7qfugjw 220 11 RSV RSV NNP cord-317619-o7qfugjw 220 12 is be VBZ cord-317619-o7qfugjw 220 13 well well RB cord-317619-o7qfugjw 220 14 reported report VBN cord-317619-o7qfugjw 220 15 ( ( -LRB- cord-317619-o7qfugjw 220 16 149 149 CD cord-317619-o7qfugjw 220 17 , , , cord-317619-o7qfugjw 220 18 150 150 CD cord-317619-o7qfugjw 220 19 ) ) -RRB- cord-317619-o7qfugjw 220 20 . . . cord-317619-o7qfugjw 221 1 In in IN cord-317619-o7qfugjw 221 2 their -PRON- PRP$ cord-317619-o7qfugjw 221 3 retrospective retrospective JJ cord-317619-o7qfugjw 221 4 review review NN cord-317619-o7qfugjw 221 5 of of IN cord-317619-o7qfugjw 221 6 151 151 CD cord-317619-o7qfugjw 221 7 children child NNS cord-317619-o7qfugjw 221 8 requiring require VBG cord-317619-o7qfugjw 221 9 mechanical mechanical JJ cord-317619-o7qfugjw 221 10 ventilation ventilation NN cord-317619-o7qfugjw 221 11 for for IN cord-317619-o7qfugjw 221 12 RSV RSV NNP cord-317619-o7qfugjw 221 13 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 221 14 , , , cord-317619-o7qfugjw 221 15 Flamant Flamant NNP cord-317619-o7qfugjw 221 16 et et NNP cord-317619-o7qfugjw 221 17 al al NNP cord-317619-o7qfugjw 221 18 . . NNP cord-317619-o7qfugjw 221 19 reported report VBD cord-317619-o7qfugjw 221 20 the the DT cord-317619-o7qfugjw 221 21 use use NN cord-317619-o7qfugjw 221 22 of of IN cord-317619-o7qfugjw 221 23 ECMO ECMO NNP cord-317619-o7qfugjw 221 24 in in IN cord-317619-o7qfugjw 221 25 14 14 CD cord-317619-o7qfugjw 221 26 patients patient NNS cord-317619-o7qfugjw 221 27 ( ( -LRB- cord-317619-o7qfugjw 221 28 151 151 CD cord-317619-o7qfugjw 221 29 ) ) -RRB- cord-317619-o7qfugjw 221 30 . . . cord-317619-o7qfugjw 222 1 In in IN cord-317619-o7qfugjw 222 2 this this DT cord-317619-o7qfugjw 222 3 study study NN cord-317619-o7qfugjw 222 4 , , , cord-317619-o7qfugjw 222 5 the the DT cord-317619-o7qfugjw 222 6 median median JJ cord-317619-o7qfugjw 222 7 duration duration NN cord-317619-o7qfugjw 222 8 of of IN cord-317619-o7qfugjw 222 9 ECMO ECMO NNP cord-317619-o7qfugjw 222 10 was be VBD cord-317619-o7qfugjw 222 11 12.5 12.5 CD cord-317619-o7qfugjw 222 12 ( ( -LRB- cord-317619-o7qfugjw 222 13 5 5 CD cord-317619-o7qfugjw 222 14 - - SYM cord-317619-o7qfugjw 222 15 18 18 CD cord-317619-o7qfugjw 222 16 ) ) -RRB- cord-317619-o7qfugjw 222 17 days day NNS cord-317619-o7qfugjw 222 18 with with IN cord-317619-o7qfugjw 222 19 a a DT cord-317619-o7qfugjw 222 20 survival survival NN cord-317619-o7qfugjw 222 21 rate rate NN cord-317619-o7qfugjw 222 22 of of IN cord-317619-o7qfugjw 222 23 71.4 71.4 CD cord-317619-o7qfugjw 222 24 % % NN cord-317619-o7qfugjw 222 25 . . . cord-317619-o7qfugjw 223 1 On on IN cord-317619-o7qfugjw 223 2 the the DT cord-317619-o7qfugjw 223 3 other other JJ cord-317619-o7qfugjw 223 4 hand hand NN cord-317619-o7qfugjw 223 5 , , , cord-317619-o7qfugjw 223 6 the the DT cord-317619-o7qfugjw 223 7 use use NN cord-317619-o7qfugjw 223 8 of of IN cord-317619-o7qfugjw 223 9 ECMO ECMO NNP cord-317619-o7qfugjw 223 10 in in IN cord-317619-o7qfugjw 223 11 pARDS pARDS NNP cord-317619-o7qfugjw 223 12 due due IN cord-317619-o7qfugjw 223 13 to to IN cord-317619-o7qfugjw 223 14 influenza influenza NN cord-317619-o7qfugjw 223 15 A a NN cord-317619-o7qfugjw 223 16 ( ( -LRB- cord-317619-o7qfugjw 223 17 H1N1 H1N1 NNP cord-317619-o7qfugjw 223 18 ) ) -RRB- cord-317619-o7qfugjw 223 19 virus virus NN cord-317619-o7qfugjw 223 20 is be VBZ cord-317619-o7qfugjw 223 21 sparsely sparsely RB cord-317619-o7qfugjw 223 22 reported report VBN cord-317619-o7qfugjw 223 23 ( ( -LRB- cord-317619-o7qfugjw 223 24 152 152 CD cord-317619-o7qfugjw 223 25 , , , cord-317619-o7qfugjw 223 26 153 153 CD cord-317619-o7qfugjw 223 27 ) ) -RRB- cord-317619-o7qfugjw 223 28 and and CC cord-317619-o7qfugjw 223 29 most most JJS cord-317619-o7qfugjw 223 30 of of IN cord-317619-o7qfugjw 223 31 our -PRON- PRP$ cord-317619-o7qfugjw 223 32 understanding understanding NN cord-317619-o7qfugjw 223 33 stems stem VBZ cord-317619-o7qfugjw 223 34 from from IN cord-317619-o7qfugjw 223 35 adult adult NN cord-317619-o7qfugjw 223 36 studies study NNS cord-317619-o7qfugjw 223 37 . . . cord-317619-o7qfugjw 224 1 In in IN cord-317619-o7qfugjw 224 2 a a DT cord-317619-o7qfugjw 224 3 study study NN cord-317619-o7qfugjw 224 4 in in IN cord-317619-o7qfugjw 224 5 Australia Australia NNP cord-317619-o7qfugjw 224 6 and and CC cord-317619-o7qfugjw 224 7 New New NNP cord-317619-o7qfugjw 224 8 Zealand Zealand NNP cord-317619-o7qfugjw 224 9 during during IN cord-317619-o7qfugjw 224 10 the the DT cord-317619-o7qfugjw 224 11 2009 2009 CD cord-317619-o7qfugjw 224 12 influenza influenza NN cord-317619-o7qfugjw 224 13 A a NN cord-317619-o7qfugjw 224 14 ( ( -LRB- cord-317619-o7qfugjw 224 15 H1N1 H1N1 NNP cord-317619-o7qfugjw 224 16 ) ) -RRB- cord-317619-o7qfugjw 224 17 pandemic pandemic NN cord-317619-o7qfugjw 224 18 , , , cord-317619-o7qfugjw 224 19 68 68 CD cord-317619-o7qfugjw 224 20 adult adult NN cord-317619-o7qfugjw 224 21 patients patient NNS cord-317619-o7qfugjw 224 22 with with IN cord-317619-o7qfugjw 224 23 influenza influenza NN cord-317619-o7qfugjw 224 24 - - HYPH cord-317619-o7qfugjw 224 25 induced induce VBN cord-317619-o7qfugjw 224 26 ARDS ARDS NNP cord-317619-o7qfugjw 224 27 were be VBD cord-317619-o7qfugjw 224 28 treated treat VBN cord-317619-o7qfugjw 224 29 with with IN cord-317619-o7qfugjw 224 30 ECMO ECMO NNP cord-317619-o7qfugjw 224 31 ( ( -LRB- cord-317619-o7qfugjw 224 32 154 154 CD cord-317619-o7qfugjw 224 33 ) ) -RRB- cord-317619-o7qfugjw 224 34 . . . cord-317619-o7qfugjw 225 1 The the DT cord-317619-o7qfugjw 225 2 median median JJ cord-317619-o7qfugjw 225 3 duration duration NN cord-317619-o7qfugjw 225 4 of of IN cord-317619-o7qfugjw 225 5 ECMO ECMO NNP cord-317619-o7qfugjw 225 6 was be VBD cord-317619-o7qfugjw 225 7 10 10 CD cord-317619-o7qfugjw 225 8 ( ( -LRB- cord-317619-o7qfugjw 225 9 7 7 CD cord-317619-o7qfugjw 225 10 - - SYM cord-317619-o7qfugjw 225 11 15 15 CD cord-317619-o7qfugjw 225 12 ) ) -RRB- cord-317619-o7qfugjw 225 13 days day NNS cord-317619-o7qfugjw 225 14 . . . cord-317619-o7qfugjw 226 1 When when WRB cord-317619-o7qfugjw 226 2 the the DT cord-317619-o7qfugjw 226 3 report report NN cord-317619-o7qfugjw 226 4 was be VBD cord-317619-o7qfugjw 226 5 submitted submit VBN cord-317619-o7qfugjw 226 6 , , , cord-317619-o7qfugjw 226 7 48 48 CD cord-317619-o7qfugjw 226 8 ( ( -LRB- cord-317619-o7qfugjw 226 9 71 71 CD cord-317619-o7qfugjw 226 10 % % NN cord-317619-o7qfugjw 226 11 ) ) -RRB- cord-317619-o7qfugjw 226 12 patients patient NNS cord-317619-o7qfugjw 226 13 had have VBD cord-317619-o7qfugjw 226 14 survived survive VBN cord-317619-o7qfugjw 226 15 to to IN cord-317619-o7qfugjw 226 16 ICU ICU NNP cord-317619-o7qfugjw 226 17 discharge discharge NN cord-317619-o7qfugjw 226 18 , , , cord-317619-o7qfugjw 226 19 with with IN cord-317619-o7qfugjw 226 20 14 14 CD cord-317619-o7qfugjw 226 21 deaths death NNS cord-317619-o7qfugjw 226 22 and and CC cord-317619-o7qfugjw 226 23 6 6 CD cord-317619-o7qfugjw 226 24 patients patient NNS cord-317619-o7qfugjw 226 25 remaining remain VBG cord-317619-o7qfugjw 226 26 in in IN cord-317619-o7qfugjw 226 27 the the DT cord-317619-o7qfugjw 226 28 ICU ICU NNP cord-317619-o7qfugjw 226 29 , , , cord-317619-o7qfugjw 226 30 2 2 CD cord-317619-o7qfugjw 226 31 of of IN cord-317619-o7qfugjw 226 32 whom whom WP cord-317619-o7qfugjw 226 33 remained remain VBD cord-317619-o7qfugjw 226 34 on on IN cord-317619-o7qfugjw 226 35 ECMO ECMO NNP cord-317619-o7qfugjw 226 36 . . . cord-317619-o7qfugjw 227 1 In in IN cord-317619-o7qfugjw 227 2 their -PRON- PRP$ cord-317619-o7qfugjw 227 3 study study NN cord-317619-o7qfugjw 227 4 in in IN cord-317619-o7qfugjw 227 5 the the DT cord-317619-o7qfugjw 227 6 United United NNP cord-317619-o7qfugjw 227 7 Kingdom Kingdom NNP cord-317619-o7qfugjw 227 8 during during IN cord-317619-o7qfugjw 227 9 the the DT cord-317619-o7qfugjw 227 10 same same JJ cord-317619-o7qfugjw 227 11 pandemic pandemic NN cord-317619-o7qfugjw 227 12 , , , cord-317619-o7qfugjw 227 13 Noah Noah NNP cord-317619-o7qfugjw 227 14 et et NNP cord-317619-o7qfugjw 227 15 al al NNP cord-317619-o7qfugjw 227 16 . . NNP cord-317619-o7qfugjw 227 17 discovered discover VBD cord-317619-o7qfugjw 227 18 a a DT cord-317619-o7qfugjw 227 19 decrease decrease NN cord-317619-o7qfugjw 227 20 in in IN cord-317619-o7qfugjw 227 21 mortality mortality NN cord-317619-o7qfugjw 227 22 for for IN cord-317619-o7qfugjw 227 23 patients patient NNS cord-317619-o7qfugjw 227 24 with with IN cord-317619-o7qfugjw 227 25 ARDS ARDS NNP cord-317619-o7qfugjw 227 26 due due IN cord-317619-o7qfugjw 227 27 to to IN cord-317619-o7qfugjw 227 28 influenza influenza NN cord-317619-o7qfugjw 227 29 A a NN cord-317619-o7qfugjw 227 30 ( ( -LRB- cord-317619-o7qfugjw 227 31 H1N1 H1N1 NNP cord-317619-o7qfugjw 227 32 ) ) -RRB- cord-317619-o7qfugjw 227 33 who who WP cord-317619-o7qfugjw 227 34 were be VBD cord-317619-o7qfugjw 227 35 referred refer VBN cord-317619-o7qfugjw 227 36 and and CC cord-317619-o7qfugjw 227 37 transferred transfer VBN cord-317619-o7qfugjw 227 38 to to IN cord-317619-o7qfugjw 227 39 an an DT cord-317619-o7qfugjw 227 40 ECMO ECMO NNP cord-317619-o7qfugjw 227 41 center center NN cord-317619-o7qfugjw 227 42 compared compare VBN cord-317619-o7qfugjw 227 43 with with IN cord-317619-o7qfugjw 227 44 matched match VBN cord-317619-o7qfugjw 227 45 non non JJ cord-317619-o7qfugjw 227 46 - - JJ cord-317619-o7qfugjw 227 47 ECMO ecmo JJ cord-317619-o7qfugjw 227 48 - - HYPH cord-317619-o7qfugjw 227 49 referred refer VBN cord-317619-o7qfugjw 227 50 patients patient NNS cord-317619-o7qfugjw 227 51 ( ( -LRB- cord-317619-o7qfugjw 227 52 155 155 CD cord-317619-o7qfugjw 227 53 ) ) -RRB- cord-317619-o7qfugjw 227 54 . . . cord-317619-o7qfugjw 228 1 In in IN cord-317619-o7qfugjw 228 2 this this DT cord-317619-o7qfugjw 228 3 study study NN cord-317619-o7qfugjw 228 4 , , , cord-317619-o7qfugjw 228 5 69 69 CD cord-317619-o7qfugjw 228 6 patients patient NNS cord-317619-o7qfugjw 228 7 received receive VBD cord-317619-o7qfugjw 228 8 ECMO ECMO NNP cord-317619-o7qfugjw 228 9 with with IN cord-317619-o7qfugjw 228 10 a a DT cord-317619-o7qfugjw 228 11 mortality mortality NN cord-317619-o7qfugjw 228 12 rate rate NN cord-317619-o7qfugjw 228 13 of of IN cord-317619-o7qfugjw 228 14 14.4 14.4 CD cord-317619-o7qfugjw 228 15 % % NN cord-317619-o7qfugjw 228 16 . . . cord-317619-o7qfugjw 229 1 Expanded expand VBN cord-317619-o7qfugjw 229 2 use use NN cord-317619-o7qfugjw 229 3 of of IN cord-317619-o7qfugjw 229 4 ECMO ECMO NNP cord-317619-o7qfugjw 229 5 within within IN cord-317619-o7qfugjw 229 6 the the DT cord-317619-o7qfugjw 229 7 pediatric pediatric JJ cord-317619-o7qfugjw 229 8 population population NN cord-317619-o7qfugjw 229 9 for for IN cord-317619-o7qfugjw 230 1 influenza influenza NNP cord-317619-o7qfugjw 230 2 A A NNP cord-317619-o7qfugjw 230 3 ( ( -LRB- cord-317619-o7qfugjw 230 4 H1N1 H1N1 NNP cord-317619-o7qfugjw 230 5 ) ) -RRB- cord-317619-o7qfugjw 230 6 virus virus NN cord-317619-o7qfugjw 230 7 induced induce VBN cord-317619-o7qfugjw 230 8 ARDS ARDS NNP cord-317619-o7qfugjw 230 9 has have VBZ cord-317619-o7qfugjw 230 10 yet yet RB cord-317619-o7qfugjw 230 11 to to TO cord-317619-o7qfugjw 230 12 be be VB cord-317619-o7qfugjw 230 13 investigated investigate VBN cord-317619-o7qfugjw 230 14 . . . cord-317619-o7qfugjw 231 1 However however RB cord-317619-o7qfugjw 231 2 , , , cord-317619-o7qfugjw 231 3 the the DT cord-317619-o7qfugjw 231 4 use use NN cord-317619-o7qfugjw 231 5 of of IN cord-317619-o7qfugjw 231 6 ECMO ECMO NNP cord-317619-o7qfugjw 231 7 in in IN cord-317619-o7qfugjw 231 8 refractory refractory JJ cord-317619-o7qfugjw 231 9 cases case NNS cord-317619-o7qfugjw 231 10 or or CC cord-317619-o7qfugjw 231 11 RSV RSV NNP cord-317619-o7qfugjw 231 12 or or CC cord-317619-o7qfugjw 231 13 influenza influenza NN cord-317619-o7qfugjw 231 14 A a NN cord-317619-o7qfugjw 231 15 ( ( -LRB- cord-317619-o7qfugjw 231 16 H1N1 H1N1 NNP cord-317619-o7qfugjw 231 17 ) ) -RRB- cord-317619-o7qfugjw 231 18 virus virus NN cord-317619-o7qfugjw 231 19 induced induce VBN cord-317619-o7qfugjw 231 20 ARDS ARDS NNP cord-317619-o7qfugjw 231 21 should should MD cord-317619-o7qfugjw 231 22 be be VB cord-317619-o7qfugjw 231 23 considered consider VBN cord-317619-o7qfugjw 231 24 when when WRB cord-317619-o7qfugjw 231 25 applicable applicable JJ cord-317619-o7qfugjw 231 26 . . . cord-317619-o7qfugjw 232 1 While while IN cord-317619-o7qfugjw 232 2 it -PRON- PRP cord-317619-o7qfugjw 232 3 is be VBZ cord-317619-o7qfugjw 232 4 clear clear JJ cord-317619-o7qfugjw 232 5 that that IN cord-317619-o7qfugjw 232 6 viral viral JJ cord-317619-o7qfugjw 232 7 infections infection NNS cord-317619-o7qfugjw 232 8 are be VBP cord-317619-o7qfugjw 232 9 an an DT cord-317619-o7qfugjw 232 10 important important JJ cord-317619-o7qfugjw 232 11 cause cause NN cord-317619-o7qfugjw 232 12 of of IN cord-317619-o7qfugjw 232 13 pediatric pediatric JJ cord-317619-o7qfugjw 232 14 ARDS ARDS NNP cord-317619-o7qfugjw 232 15 , , , cord-317619-o7qfugjw 232 16 the the DT cord-317619-o7qfugjw 232 17 exact exact JJ cord-317619-o7qfugjw 232 18 disease disease NN cord-317619-o7qfugjw 232 19 burden burden NN cord-317619-o7qfugjw 232 20 remains remain VBZ cord-317619-o7qfugjw 232 21 unknown unknown JJ cord-317619-o7qfugjw 232 22 . . . cord-317619-o7qfugjw 233 1 With with IN cord-317619-o7qfugjw 233 2 more more RBR cord-317619-o7qfugjw 233 3 definitive definitive JJ cord-317619-o7qfugjw 233 4 diagnostic diagnostic JJ cord-317619-o7qfugjw 233 5 criteria criterion NNS cord-317619-o7qfugjw 233 6 , , , cord-317619-o7qfugjw 233 7 clinicians clinician NNS cord-317619-o7qfugjw 233 8 now now RB cord-317619-o7qfugjw 233 9 have have VBP cord-317619-o7qfugjw 233 10 a a DT cord-317619-o7qfugjw 233 11 wide wide JJ cord-317619-o7qfugjw 233 12 array array NN cord-317619-o7qfugjw 233 13 of of IN cord-317619-o7qfugjw 233 14 research research NN cord-317619-o7qfugjw 233 15 possibilities possibility NNS cord-317619-o7qfugjw 233 16 regarding regard VBG cord-317619-o7qfugjw 233 17 pediatric pediatric JJ cord-317619-o7qfugjw 233 18 ARDS ARDS NNP cord-317619-o7qfugjw 233 19 , , , cord-317619-o7qfugjw 233 20 both both CC cord-317619-o7qfugjw 233 21 retrospective retrospective JJ cord-317619-o7qfugjw 233 22 and and CC cord-317619-o7qfugjw 233 23 prospective prospective JJ cord-317619-o7qfugjw 233 24 . . . cord-317619-o7qfugjw 234 1 Further further JJ cord-317619-o7qfugjw 234 2 studies study NNS cord-317619-o7qfugjw 234 3 to to TO cord-317619-o7qfugjw 234 4 expand expand VB cord-317619-o7qfugjw 234 5 our -PRON- PRP$ cord-317619-o7qfugjw 234 6 understanding understanding NN cord-317619-o7qfugjw 234 7 of of IN cord-317619-o7qfugjw 234 8 viral viral RB cord-317619-o7qfugjw 234 9 - - HYPH cord-317619-o7qfugjw 234 10 induced induce VBN cord-317619-o7qfugjw 234 11 pediatric pediatric JJ cord-317619-o7qfugjw 234 12 ARDS ARDS NNP cord-317619-o7qfugjw 234 13 will will MD cord-317619-o7qfugjw 234 14 be be VB cord-317619-o7qfugjw 234 15 of of IN cord-317619-o7qfugjw 234 16 great great JJ cord-317619-o7qfugjw 234 17 benefit benefit NN cord-317619-o7qfugjw 234 18 , , , cord-317619-o7qfugjw 234 19 both both CC cord-317619-o7qfugjw 234 20 in in IN cord-317619-o7qfugjw 234 21 understanding understand VBG cord-317619-o7qfugjw 234 22 the the DT cord-317619-o7qfugjw 234 23 epidemiology epidemiology NN cord-317619-o7qfugjw 234 24 and and CC cord-317619-o7qfugjw 234 25 viral viral JJ cord-317619-o7qfugjw 234 26 - - HYPH cord-317619-o7qfugjw 234 27 specific specific JJ cord-317619-o7qfugjw 234 28 treatment treatment NN cord-317619-o7qfugjw 234 29 options option NNS cord-317619-o7qfugjw 234 30 available available JJ cord-317619-o7qfugjw 234 31 . . . cord-317619-o7qfugjw 235 1 In in IN cord-317619-o7qfugjw 235 2 addition addition NN cord-317619-o7qfugjw 235 3 , , , cord-317619-o7qfugjw 235 4 an an DT cord-317619-o7qfugjw 235 5 improved improved JJ cord-317619-o7qfugjw 235 6 comprehension comprehension NN cord-317619-o7qfugjw 235 7 of of IN cord-317619-o7qfugjw 235 8 viral viral JJ cord-317619-o7qfugjw 235 9 transmission transmission NN cord-317619-o7qfugjw 235 10 , , , cord-317619-o7qfugjw 235 11 pathogenicity pathogenicity NN cord-317619-o7qfugjw 235 12 , , , cord-317619-o7qfugjw 235 13 and and CC cord-317619-o7qfugjw 235 14 host host NN cord-317619-o7qfugjw 235 15 response response NN cord-317619-o7qfugjw 235 16 will will MD cord-317619-o7qfugjw 235 17 be be VB cord-317619-o7qfugjw 235 18 particularly particularly RB cord-317619-o7qfugjw 235 19 important important JJ cord-317619-o7qfugjw 235 20 in in IN cord-317619-o7qfugjw 235 21 times time NNS cord-317619-o7qfugjw 235 22 of of IN cord-317619-o7qfugjw 235 23 pandemics pandemic NNS cord-317619-o7qfugjw 235 24 , , , cord-317619-o7qfugjw 235 25 either either CC cord-317619-o7qfugjw 235 26 from from IN cord-317619-o7qfugjw 235 27 known know VBN cord-317619-o7qfugjw 235 28 or or CC cord-317619-o7qfugjw 235 29 novel novel JJ cord-317619-o7qfugjw 235 30 viruses virus NNS cord-317619-o7qfugjw 235 31 . . . cord-317619-o7qfugjw 236 1 Finally finally RB cord-317619-o7qfugjw 236 2 , , , cord-317619-o7qfugjw 236 3 continued continue VBN cord-317619-o7qfugjw 236 4 efforts effort NNS cord-317619-o7qfugjw 236 5 in in IN cord-317619-o7qfugjw 236 6 prevention prevention NN cord-317619-o7qfugjw 236 7 and and CC cord-317619-o7qfugjw 236 8 treatment treatment NN cord-317619-o7qfugjw 236 9 of of IN cord-317619-o7qfugjw 236 10 viral viral JJ cord-317619-o7qfugjw 236 11 infections infection NNS cord-317619-o7qfugjw 236 12 will will MD cord-317619-o7qfugjw 236 13 likely likely RB cord-317619-o7qfugjw 236 14 be be VB cord-317619-o7qfugjw 236 15 of of IN cord-317619-o7qfugjw 236 16 greatest great JJS cord-317619-o7qfugjw 236 17 advantage advantage NN cord-317619-o7qfugjw 236 18 to to TO cord-317619-o7qfugjw 236 19 decrease decrease VB cord-317619-o7qfugjw 236 20 viral viral JJ cord-317619-o7qfugjw 236 21 progression progression NN cord-317619-o7qfugjw 236 22 to to IN cord-317619-o7qfugjw 236 23 pediatric pediatric JJ cord-317619-o7qfugjw 236 24 ARDS ARDS NNP cord-317619-o7qfugjw 236 25 . . . cord-317619-o7qfugjw 237 1 SN SN NNP cord-317619-o7qfugjw 237 2 , , , cord-317619-o7qfugjw 237 3 RW RW NNP cord-317619-o7qfugjw 237 4 , , , cord-317619-o7qfugjw 237 5 and and CC cord-317619-o7qfugjw 237 6 MK MK NNP cord-317619-o7qfugjw 237 7 contributed contribute VBD cord-317619-o7qfugjw 237 8 to to IN cord-317619-o7qfugjw 237 9 the the DT cord-317619-o7qfugjw 237 10 conception conception NN cord-317619-o7qfugjw 237 11 , , , cord-317619-o7qfugjw 237 12 writing writing NN cord-317619-o7qfugjw 237 13 , , , cord-317619-o7qfugjw 237 14 and and CC cord-317619-o7qfugjw 237 15 final final JJ cord-317619-o7qfugjw 237 16 edits edit NNS cord-317619-o7qfugjw 237 17 of of IN cord-317619-o7qfugjw 237 18 this this DT cord-317619-o7qfugjw 237 19 manuscript manuscript NN cord-317619-o7qfugjw 237 20 . . . cord-317619-o7qfugjw 238 1 This this DT cord-317619-o7qfugjw 238 2 work work NN cord-317619-o7qfugjw 238 3 was be VBD cord-317619-o7qfugjw 238 4 funded fund VBN cord-317619-o7qfugjw 238 5 by by IN cord-317619-o7qfugjw 238 6 the the DT cord-317619-o7qfugjw 238 7 National National NNP cord-317619-o7qfugjw 238 8 Institutes Institutes NNPS cord-317619-o7qfugjw 238 9 of of IN cord-317619-o7qfugjw 238 10 Health Health NNP cord-317619-o7qfugjw 238 11 ( ( -LRB- cord-317619-o7qfugjw 238 12 NICHD NICHD NNP cord-317619-o7qfugjw 238 13 5K12HD047349 5K12HD047349 NNP cord-317619-o7qfugjw 238 14 and and CC cord-317619-o7qfugjw 238 15 5K08HL119359 5k08hl119359 CD cord-317619-o7qfugjw 238 16 - - SYM cord-317619-o7qfugjw 238 17 02 02 CD cord-317619-o7qfugjw 238 18 ) ) -RRB- cord-317619-o7qfugjw 238 19 to to IN cord-317619-o7qfugjw 238 20 MK MK NNP cord-317619-o7qfugjw 238 21 . . . cord-317619-o7qfugjw 238 22 _SP cord-317619-o7qfugjw 239 1 Middle Middle NNP cord-317619-o7qfugjw 239 2 East East NNP cord-317619-o7qfugjw 239 3 respiratory respiratory JJ cord-317619-o7qfugjw 239 4 syndrome syndrome NN cord-317619-o7qfugjw 239 5 Acute acute JJ cord-317619-o7qfugjw 239 6 management management NN cord-317619-o7qfugjw 239 7 and and CC cord-317619-o7qfugjw 239 8 long long JJ cord-317619-o7qfugjw 239 9 - - HYPH cord-317619-o7qfugjw 239 10 term term NN cord-317619-o7qfugjw 239 11 survival survival NN cord-317619-o7qfugjw 239 12 among among IN cord-317619-o7qfugjw 239 13 subjects subject NNS cord-317619-o7qfugjw 239 14 with with IN cord-317619-o7qfugjw 239 15 severe severe JJ cord-317619-o7qfugjw 239 16 Middle Middle NNP cord-317619-o7qfugjw 239 17 East East NNP cord-317619-o7qfugjw 239 18 respiratory respiratory JJ cord-317619-o7qfugjw 239 19 syndrome syndrome NN cord-317619-o7qfugjw 239 20 coronavirus coronavirus NN cord-317619-o7qfugjw 239 21 pneumonia pneumonia NN cord-317619-o7qfugjw 239 22 and and CC cord-317619-o7qfugjw 239 23 ARDS ARDS NNP cord-317619-o7qfugjw 239 24 Herpes Herpes NNP cord-317619-o7qfugjw 239 25 simplex simplex NN cord-317619-o7qfugjw 239 26 virus virus NN cord-317619-o7qfugjw 239 27 in in IN cord-317619-o7qfugjw 239 28 the the DT cord-317619-o7qfugjw 239 29 respiratory respiratory JJ cord-317619-o7qfugjw 239 30 tract tract NN cord-317619-o7qfugjw 239 31 of of IN cord-317619-o7qfugjw 239 32 critical critical JJ cord-317619-o7qfugjw 239 33 care care NN cord-317619-o7qfugjw 239 34 patients patient NNS cord-317619-o7qfugjw 239 35 : : : cord-317619-o7qfugjw 239 36 a a DT cord-317619-o7qfugjw 239 37 prospective prospective JJ cord-317619-o7qfugjw 239 38 study study NN cord-317619-o7qfugjw 239 39 Herpes Herpes NNP cord-317619-o7qfugjw 239 40 simplex simplex NN cord-317619-o7qfugjw 239 41 virus virus NN cord-317619-o7qfugjw 239 42 lung lung NN cord-317619-o7qfugjw 239 43 infection infection NN cord-317619-o7qfugjw 239 44 in in IN cord-317619-o7qfugjw 239 45 patients patient NNS cord-317619-o7qfugjw 239 46 undergoing undergo VBG cord-317619-o7qfugjw 239 47 prolonged prolong VBN cord-317619-o7qfugjw 239 48 mechanical mechanical JJ cord-317619-o7qfugjw 239 49 ventilation ventilation NN cord-317619-o7qfugjw 239 50 Vandenbroucke Vandenbroucke NNP cord-317619-o7qfugjw 239 51 - - HYPH cord-317619-o7qfugjw 239 52 Grauls Grauls NNP cord-317619-o7qfugjw 239 53 CM CM NNP cord-317619-o7qfugjw 239 54 . . . cord-317619-o7qfugjw 240 1 Herpes Herpes NNP cord-317619-o7qfugjw 240 2 simplex simplex NN cord-317619-o7qfugjw 240 3 virus virus NN cord-317619-o7qfugjw 240 4 type type NN cord-317619-o7qfugjw 240 5 1 1 CD cord-317619-o7qfugjw 240 6 and and CC cord-317619-o7qfugjw 240 7 respiratory respiratory JJ cord-317619-o7qfugjw 240 8 disease disease NN cord-317619-o7qfugjw 240 9 in in IN cord-317619-o7qfugjw 240 10 critically critically RB cord-317619-o7qfugjw 240 11 - - HYPH cord-317619-o7qfugjw 240 12 ill ill JJ cord-317619-o7qfugjw 240 13 patients patient NNS cord-317619-o7qfugjw 240 14 : : : cord-317619-o7qfugjw 240 15 real real JJ cord-317619-o7qfugjw 240 16 pathogen pathogen NN cord-317619-o7qfugjw 240 17 or or CC cord-317619-o7qfugjw 240 18 innocent innocent JJ cord-317619-o7qfugjw 240 19 bystander bystander NN cord-317619-o7qfugjw 240 20 ? ? . cord-317619-o7qfugjw 241 1 Herpes Herpes NNP cord-317619-o7qfugjw 241 2 simplex simplex NN cord-317619-o7qfugjw 241 3 virus virus NN cord-317619-o7qfugjw 241 4 from from IN cord-317619-o7qfugjw 241 5 respiratory respiratory JJ cord-317619-o7qfugjw 241 6 tract tract NN cord-317619-o7qfugjw 241 7 secretions secretion NNS cord-317619-o7qfugjw 241 8 : : : cord-317619-o7qfugjw 241 9 epidemiology epidemiology NN cord-317619-o7qfugjw 241 10 , , , cord-317619-o7qfugjw 241 11 clinical clinical JJ cord-317619-o7qfugjw 241 12 characteristics characteristic NNS cord-317619-o7qfugjw 241 13 , , , cord-317619-o7qfugjw 241 14 and and CC cord-317619-o7qfugjw 241 15 outcome outcome NN cord-317619-o7qfugjw 241 16 in in IN cord-317619-o7qfugjw 241 17 immunocompromised immunocompromised JJ cord-317619-o7qfugjw 241 18 and and CC cord-317619-o7qfugjw 241 19 nonimmunocompromised nonimmunocompromised JJ cord-317619-o7qfugjw 241 20 hosts host NNS cord-317619-o7qfugjw 241 21 Life Life NNP cord-317619-o7qfugjw 241 22 - - HYPH cord-317619-o7qfugjw 241 23 threatening threaten VBG cord-317619-o7qfugjw 241 24 human human JJ cord-317619-o7qfugjw 241 25 herpes herpe NNS cord-317619-o7qfugjw 241 26 virus-6 virus-6 NNP cord-317619-o7qfugjw 241 27 infection infection NN cord-317619-o7qfugjw 241 28 in in IN cord-317619-o7qfugjw 241 29 early early JJ cord-317619-o7qfugjw 241 30 childhood childhood NN cord-317619-o7qfugjw 241 31 : : : cord-317619-o7qfugjw 241 32 presenting present VBG cord-317619-o7qfugjw 241 33 symptom symptom NN cord-317619-o7qfugjw 241 34 of of IN cord-317619-o7qfugjw 241 35 a a DT cord-317619-o7qfugjw 241 36 primary primary JJ cord-317619-o7qfugjw 241 37 immunodeficiency immunodeficiency NN cord-317619-o7qfugjw 241 38 ? ? . cord-317619-o7qfugjw 242 1 Treatment treatment NN cord-317619-o7qfugjw 242 2 of of IN cord-317619-o7qfugjw 242 3 acute acute JJ cord-317619-o7qfugjw 242 4 pulmonary pulmonary JJ cord-317619-o7qfugjw 242 5 failure failure NN cord-317619-o7qfugjw 242 6 with with IN cord-317619-o7qfugjw 242 7 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 242 8 support support NN cord-317619-o7qfugjw 242 9 : : : cord-317619-o7qfugjw 242 10 100 100 CD cord-317619-o7qfugjw 242 11 % % NN cord-317619-o7qfugjw 242 12 survival survival NN cord-317619-o7qfugjw 242 13 in in IN cord-317619-o7qfugjw 242 14 a a DT cord-317619-o7qfugjw 242 15 pediatric pediatric JJ cord-317619-o7qfugjw 242 16 population population NN cord-317619-o7qfugjw 242 17 Characterisation Characterisation NNP cord-317619-o7qfugjw 242 18 of of IN cord-317619-o7qfugjw 242 19 nosocomial nosocomial JJ cord-317619-o7qfugjw 242 20 and and CC cord-317619-o7qfugjw 242 21 community community NN cord-317619-o7qfugjw 242 22 - - HYPH cord-317619-o7qfugjw 242 23 acquired acquire VBN cord-317619-o7qfugjw 242 24 influenza influenza NN cord-317619-o7qfugjw 242 25 in in IN cord-317619-o7qfugjw 242 26 a a DT cord-317619-o7qfugjw 242 27 large large JJ cord-317619-o7qfugjw 242 28 university university NN cord-317619-o7qfugjw 242 29 hospital hospital NN cord-317619-o7qfugjw 242 30 during during IN cord-317619-o7qfugjw 242 31 two two CD cord-317619-o7qfugjw 242 32 consecutive consecutive JJ cord-317619-o7qfugjw 242 33 influenza influenza NN cord-317619-o7qfugjw 242 34 seasons season NNS cord-317619-o7qfugjw 242 35 guideline guideline NN cord-317619-o7qfugjw 242 36 for for IN cord-317619-o7qfugjw 242 37 isolation isolation NN cord-317619-o7qfugjw 242 38 precautions precaution NNS cord-317619-o7qfugjw 242 39 : : : cord-317619-o7qfugjw 242 40 preventing prevent VBG cord-317619-o7qfugjw 242 41 transmission transmission NN cord-317619-o7qfugjw 242 42 of of IN cord-317619-o7qfugjw 242 43 infectious infectious JJ cord-317619-o7qfugjw 242 44 agents agent NNS cord-317619-o7qfugjw 242 45 in in IN cord-317619-o7qfugjw 242 46 health health NN cord-317619-o7qfugjw 242 47 care care NN cord-317619-o7qfugjw 242 48 settings setting NNS cord-317619-o7qfugjw 242 49 Contact contact VBP cord-317619-o7qfugjw 242 50 precautions precaution NNS cord-317619-o7qfugjw 242 51 : : : cord-317619-o7qfugjw 242 52 more more JJR cord-317619-o7qfugjw 242 53 is be VBZ cord-317619-o7qfugjw 242 54 not not RB cord-317619-o7qfugjw 242 55 necessarily necessarily RB cord-317619-o7qfugjw 242 56 better well JJR cord-317619-o7qfugjw 242 57 Multiplex Multiplex NNP cord-317619-o7qfugjw 242 58 PCR PCR NNP cord-317619-o7qfugjw 242 59 for for IN cord-317619-o7qfugjw 242 60 typing typing NN cord-317619-o7qfugjw 242 61 and and CC cord-317619-o7qfugjw 242 62 subtyping subtyping NN cord-317619-o7qfugjw 242 63 influenza influenza NN cord-317619-o7qfugjw 242 64 and and CC cord-317619-o7qfugjw 242 65 respiratory respiratory JJ cord-317619-o7qfugjw 242 66 syncytial syncytial JJ cord-317619-o7qfugjw 242 67 viruses virus NNS cord-317619-o7qfugjw 243 1 Multiplex multiplex JJ cord-317619-o7qfugjw 243 2 real real JJ cord-317619-o7qfugjw 243 3 - - HYPH cord-317619-o7qfugjw 243 4 time time NN cord-317619-o7qfugjw 243 5 PCR PCR NNP cord-317619-o7qfugjw 243 6 assay assay NN cord-317619-o7qfugjw 243 7 for for IN cord-317619-o7qfugjw 243 8 detection detection NN cord-317619-o7qfugjw 243 9 of of IN cord-317619-o7qfugjw 243 10 influenza influenza NN cord-317619-o7qfugjw 243 11 and and CC cord-317619-o7qfugjw 243 12 human human JJ cord-317619-o7qfugjw 243 13 respiratory respiratory JJ cord-317619-o7qfugjw 243 14 syncytial syncytial NN cord-317619-o7qfugjw 243 15 viruses virus NNS cord-317619-o7qfugjw 243 16 Emergence emergence NN cord-317619-o7qfugjw 243 17 of of IN cord-317619-o7qfugjw 243 18 a a DT cord-317619-o7qfugjw 243 19 novel novel JJ cord-317619-o7qfugjw 243 20 swine swine NN cord-317619-o7qfugjw 243 21 - - HYPH cord-317619-o7qfugjw 243 22 origin origin NN cord-317619-o7qfugjw 243 23 influenza influenza NN cord-317619-o7qfugjw 243 24 A A NNP cord-317619-o7qfugjw 243 25 ( ( -LRB- cord-317619-o7qfugjw 243 26 H1N1 H1N1 NNP cord-317619-o7qfugjw 243 27 ) ) -RRB- cord-317619-o7qfugjw 243 28 virus virus NN cord-317619-o7qfugjw 243 29 in in IN cord-317619-o7qfugjw 243 30 humans human NNS cord-317619-o7qfugjw 244 1 The the DT cord-317619-o7qfugjw 244 2 influenza influenza NN cord-317619-o7qfugjw 244 3 virus virus NN cord-317619-o7qfugjw 244 4 : : : cord-317619-o7qfugjw 244 5 disease disease NN cord-317619-o7qfugjw 244 6 , , , cord-317619-o7qfugjw 244 7 diagnostics diagnostic NNS cord-317619-o7qfugjw 244 8 , , , cord-317619-o7qfugjw 244 9 and and CC cord-317619-o7qfugjw 244 10 treatment treatment NN cord-317619-o7qfugjw 244 11 Evaluation Evaluation NNP cord-317619-o7qfugjw 244 12 of of IN cord-317619-o7qfugjw 244 13 novel novel JJ cord-317619-o7qfugjw 244 14 second second JJ cord-317619-o7qfugjw 244 15 - - HYPH cord-317619-o7qfugjw 244 16 generation generation NN cord-317619-o7qfugjw 244 17 RSV RSV NNP cord-317619-o7qfugjw 244 18 and and CC cord-317619-o7qfugjw 244 19 influenza influenza JJ cord-317619-o7qfugjw 244 20 rapid rapid JJ cord-317619-o7qfugjw 244 21 tests test NNS cord-317619-o7qfugjw 244 22 at at IN cord-317619-o7qfugjw 244 23 the the DT cord-317619-o7qfugjw 244 24 point point NN cord-317619-o7qfugjw 244 25 of of IN cord-317619-o7qfugjw 244 26 care care NN cord-317619-o7qfugjw 244 27 Accuracy accuracy NN cord-317619-o7qfugjw 244 28 of of IN cord-317619-o7qfugjw 244 29 rapid rapid JJ cord-317619-o7qfugjw 244 30 influenza influenza NN cord-317619-o7qfugjw 244 31 diagnostic diagnostic JJ cord-317619-o7qfugjw 244 32 tests test NNS cord-317619-o7qfugjw 244 33 : : : cord-317619-o7qfugjw 244 34 a a DT cord-317619-o7qfugjw 244 35 meta meta JJ cord-317619-o7qfugjw 244 36 - - HYPH cord-317619-o7qfugjw 244 37 analysis analysis NN cord-317619-o7qfugjw 244 38 Antigen antigen NN cord-317619-o7qfugjw 244 39 - - HYPH cord-317619-o7qfugjw 244 40 based base VBN cord-317619-o7qfugjw 244 41 assays assay NNS cord-317619-o7qfugjw 244 42 for for IN cord-317619-o7qfugjw 244 43 the the DT cord-317619-o7qfugjw 244 44 identification identification NN cord-317619-o7qfugjw 244 45 of of IN cord-317619-o7qfugjw 244 46 influenza influenza NN cord-317619-o7qfugjw 244 47 virus virus NN cord-317619-o7qfugjw 244 48 and and CC cord-317619-o7qfugjw 244 49 respiratory respiratory JJ cord-317619-o7qfugjw 244 50 syncytial syncytial JJ cord-317619-o7qfugjw 244 51 virus virus NN cord-317619-o7qfugjw 244 52 : : : cord-317619-o7qfugjw 244 53 why why WRB cord-317619-o7qfugjw 244 54 and and CC cord-317619-o7qfugjw 244 55 how how WRB cord-317619-o7qfugjw 244 56 to to TO cord-317619-o7qfugjw 244 57 use use VB cord-317619-o7qfugjw 244 58 them -PRON- PRP cord-317619-o7qfugjw 244 59 in in IN cord-317619-o7qfugjw 244 60 pediatric pediatric JJ cord-317619-o7qfugjw 244 61 practice practice NN cord-317619-o7qfugjw 245 1 Diagnostic diagnostic JJ cord-317619-o7qfugjw 245 2 performance performance NN cord-317619-o7qfugjw 245 3 of of IN cord-317619-o7qfugjw 245 4 influenza influenza NN cord-317619-o7qfugjw 245 5 viruses virus NNS cord-317619-o7qfugjw 245 6 and and CC cord-317619-o7qfugjw 245 7 RSV RSV NNP cord-317619-o7qfugjw 245 8 rapid rapid JJ cord-317619-o7qfugjw 245 9 antigen antigen NN cord-317619-o7qfugjw 245 10 detection detection NN cord-317619-o7qfugjw 245 11 tests test NNS cord-317619-o7qfugjw 245 12 in in IN cord-317619-o7qfugjw 245 13 children child NNS cord-317619-o7qfugjw 245 14 in in IN cord-317619-o7qfugjw 245 15 tertiary tertiary JJ cord-317619-o7qfugjw 245 16 care care NN cord-317619-o7qfugjw 245 17 World World NNP cord-317619-o7qfugjw 245 18 Health Health NNP cord-317619-o7qfugjw 245 19 Organization Organization NNP cord-317619-o7qfugjw 245 20 . . . cord-317619-o7qfugjw 246 1 WHO who WP cord-317619-o7qfugjw 246 2 Recommendations recommendation VBZ cord-317619-o7qfugjw 246 3 on on IN cord-317619-o7qfugjw 246 4 the the DT cord-317619-o7qfugjw 246 5 Use Use NNP cord-317619-o7qfugjw 246 6 of of IN cord-317619-o7qfugjw 246 7 Rapid Rapid NNP cord-317619-o7qfugjw 246 8 Testing Testing NNP cord-317619-o7qfugjw 246 9 for for IN cord-317619-o7qfugjw 246 10 Influenza Influenza NNP cord-317619-o7qfugjw 246 11 Diagnosis Diagnosis NNP cord-317619-o7qfugjw 246 12 Comparison Comparison NNP cord-317619-o7qfugjw 246 13 of of IN cord-317619-o7qfugjw 246 14 human human JJ cord-317619-o7qfugjw 246 15 metapneumovirus metapneumovirus NN cord-317619-o7qfugjw 246 16 , , , cord-317619-o7qfugjw 246 17 respiratory respiratory JJ cord-317619-o7qfugjw 246 18 syncytial syncytial JJ cord-317619-o7qfugjw 246 19 virus virus NN cord-317619-o7qfugjw 246 20 and and CC cord-317619-o7qfugjw 246 21 rhinovirus rhinovirus NN cord-317619-o7qfugjw 246 22 respiratory respiratory JJ cord-317619-o7qfugjw 246 23 tract tract NN cord-317619-o7qfugjw 246 24 infections infection NNS cord-317619-o7qfugjw 246 25 in in IN cord-317619-o7qfugjw 246 26 young young JJ cord-317619-o7qfugjw 246 27 children child NNS cord-317619-o7qfugjw 246 28 admitted admit VBN cord-317619-o7qfugjw 246 29 to to IN cord-317619-o7qfugjw 246 30 hospital hospital NN cord-317619-o7qfugjw 246 31 Role role NN cord-317619-o7qfugjw 246 32 of of IN cord-317619-o7qfugjw 246 33 respiratory respiratory JJ cord-317619-o7qfugjw 246 34 viruses virus NNS cord-317619-o7qfugjw 246 35 in in IN cord-317619-o7qfugjw 246 36 acute acute JJ cord-317619-o7qfugjw 246 37 upper upper JJ cord-317619-o7qfugjw 246 38 and and CC cord-317619-o7qfugjw 246 39 lower low JJR cord-317619-o7qfugjw 246 40 respiratory respiratory JJ cord-317619-o7qfugjw 246 41 tract tract NN cord-317619-o7qfugjw 246 42 illness illness NN cord-317619-o7qfugjw 246 43 in in IN cord-317619-o7qfugjw 246 44 the the DT cord-317619-o7qfugjw 246 45 first first JJ cord-317619-o7qfugjw 246 46 year year NN cord-317619-o7qfugjw 246 47 of of IN cord-317619-o7qfugjw 246 48 life life NN cord-317619-o7qfugjw 246 49 : : : cord-317619-o7qfugjw 246 50 a a DT cord-317619-o7qfugjw 246 51 birth birth NN cord-317619-o7qfugjw 246 52 cohort cohort NN cord-317619-o7qfugjw 246 53 study study NN cord-317619-o7qfugjw 246 54 Predictors Predictors NNP cord-317619-o7qfugjw 246 55 of of IN cord-317619-o7qfugjw 246 56 RSV RSV NNP cord-317619-o7qfugjw 246 57 LRTI LRTI NNP cord-317619-o7qfugjw 246 58 hospitalization hospitalization NN cord-317619-o7qfugjw 246 59 in in IN cord-317619-o7qfugjw 246 60 infants infant NNS cord-317619-o7qfugjw 246 61 born bear VBN cord-317619-o7qfugjw 246 62 at at IN cord-317619-o7qfugjw 246 63 33 33 CD cord-317619-o7qfugjw 246 64 to to TO cord-317619-o7qfugjw 246 65 35 35 CD cord-317619-o7qfugjw 246 66 weeks week NNS cord-317619-o7qfugjw 246 67 gestational gestational JJ cord-317619-o7qfugjw 246 68 age age NN cord-317619-o7qfugjw 246 69 : : : cord-317619-o7qfugjw 246 70 a a DT cord-317619-o7qfugjw 246 71 large large JJ cord-317619-o7qfugjw 246 72 multinational multinational JJ cord-317619-o7qfugjw 246 73 study study NN cord-317619-o7qfugjw 246 74 ( ( -LRB- cord-317619-o7qfugjw 246 75 PONI PONI NNP cord-317619-o7qfugjw 246 76 ) ) -RRB- cord-317619-o7qfugjw 246 77 Populations population NNS cord-317619-o7qfugjw 246 78 at at IN cord-317619-o7qfugjw 246 79 risk risk NN cord-317619-o7qfugjw 246 80 for for IN cord-317619-o7qfugjw 246 81 developing develop VBG cord-317619-o7qfugjw 246 82 respiratory respiratory JJ cord-317619-o7qfugjw 246 83 syncytial syncytial JJ cord-317619-o7qfugjw 246 84 virus virus NN cord-317619-o7qfugjw 246 85 and and CC cord-317619-o7qfugjw 246 86 risk risk NN cord-317619-o7qfugjw 246 87 factors factor NNS cord-317619-o7qfugjw 246 88 for for IN cord-317619-o7qfugjw 246 89 respiratory respiratory JJ cord-317619-o7qfugjw 246 90 syncytial syncytial JJ cord-317619-o7qfugjw 246 91 virus virus NN cord-317619-o7qfugjw 246 92 severity severity NN cord-317619-o7qfugjw 246 93 : : : cord-317619-o7qfugjw 246 94 infants infant NNS cord-317619-o7qfugjw 246 95 with with IN cord-317619-o7qfugjw 246 96 predisposing predispose VBG cord-317619-o7qfugjw 246 97 conditions condition NNS cord-317619-o7qfugjw 247 1 Children child NNS cord-317619-o7qfugjw 247 2 's 's POS cord-317619-o7qfugjw 247 3 Hospital Hospital NNP cord-317619-o7qfugjw 247 4 respiratory respiratory JJ cord-317619-o7qfugjw 247 5 syncytial syncytial JJ cord-317619-o7qfugjw 247 6 virus virus NN cord-317619-o7qfugjw 247 7 database database NN cord-317619-o7qfugjw 247 8 : : : cord-317619-o7qfugjw 247 9 risk risk NN cord-317619-o7qfugjw 247 10 factors factor NNS cord-317619-o7qfugjw 247 11 , , , cord-317619-o7qfugjw 247 12 treatment treatment NN cord-317619-o7qfugjw 247 13 and and CC cord-317619-o7qfugjw 247 14 hospital hospital NN cord-317619-o7qfugjw 247 15 course course NN cord-317619-o7qfugjw 247 16 in in IN cord-317619-o7qfugjw 247 17 3308 3308 CD cord-317619-o7qfugjw 247 18 infants infant NNS cord-317619-o7qfugjw 247 19 and and CC cord-317619-o7qfugjw 247 20 young young JJ cord-317619-o7qfugjw 247 21 children child NNS cord-317619-o7qfugjw 248 1 Birth birth NN cord-317619-o7qfugjw 248 2 weight weight NN cord-317619-o7qfugjw 248 3 and and CC cord-317619-o7qfugjw 248 4 hospital hospital NN cord-317619-o7qfugjw 248 5 readmission readmission NN cord-317619-o7qfugjw 248 6 of of IN cord-317619-o7qfugjw 248 7 infants infant NNS cord-317619-o7qfugjw 248 8 born bear VBN cord-317619-o7qfugjw 248 9 prematurely prematurely RB cord-317619-o7qfugjw 248 10 Respiratory respiratory JJ cord-317619-o7qfugjw 248 11 syncytial syncytial JJ cord-317619-o7qfugjw 248 12 virus virus NN cord-317619-o7qfugjw 248 13 and and CC cord-317619-o7qfugjw 248 14 premature premature JJ cord-317619-o7qfugjw 248 15 infants infant NNS cord-317619-o7qfugjw 248 16 born bear VBN cord-317619-o7qfugjw 248 17 at at IN cord-317619-o7qfugjw 248 18 32 32 CD cord-317619-o7qfugjw 248 19 weeks week NNS cord-317619-o7qfugjw 248 20 ' ' POS cord-317619-o7qfugjw 248 21 gestation gestation NN cord-317619-o7qfugjw 248 22 or or CC cord-317619-o7qfugjw 248 23 earlier early JJR cord-317619-o7qfugjw 248 24 : : : cord-317619-o7qfugjw 248 25 hospitalization hospitalization NN cord-317619-o7qfugjw 248 26 and and CC cord-317619-o7qfugjw 248 27 economic economic JJ cord-317619-o7qfugjw 248 28 implications implication NNS cord-317619-o7qfugjw 248 29 of of IN cord-317619-o7qfugjw 248 30 prophylaxis prophylaxis NN cord-317619-o7qfugjw 248 31 Readmission readmission NN cord-317619-o7qfugjw 248 32 with with IN cord-317619-o7qfugjw 248 33 respiratory respiratory JJ cord-317619-o7qfugjw 248 34 syncytial syncytial JJ cord-317619-o7qfugjw 248 35 virus virus NN cord-317619-o7qfugjw 248 36 ( ( -LRB- cord-317619-o7qfugjw 248 37 RSV RSV NNP cord-317619-o7qfugjw 248 38 ) ) -RRB- cord-317619-o7qfugjw 248 39 infection infection NN cord-317619-o7qfugjw 248 40 among among IN cord-317619-o7qfugjw 248 41 graduates graduate NNS cord-317619-o7qfugjw 248 42 from from IN cord-317619-o7qfugjw 248 43 a a DT cord-317619-o7qfugjw 248 44 neonatal neonatal JJ cord-317619-o7qfugjw 248 45 intensive intensive JJ cord-317619-o7qfugjw 248 46 care care NN cord-317619-o7qfugjw 248 47 unit unit NN cord-317619-o7qfugjw 248 48 Predictors Predictors NNP cord-317619-o7qfugjw 248 49 of of IN cord-317619-o7qfugjw 248 50 severity severity NN cord-317619-o7qfugjw 248 51 and and CC cord-317619-o7qfugjw 248 52 mortality mortality NN cord-317619-o7qfugjw 248 53 in in IN cord-317619-o7qfugjw 248 54 children child NNS cord-317619-o7qfugjw 248 55 hospitalized hospitalize VBN cord-317619-o7qfugjw 248 56 with with IN cord-317619-o7qfugjw 248 57 respiratory respiratory JJ cord-317619-o7qfugjw 248 58 syncytial syncytial JJ cord-317619-o7qfugjw 248 59 virus virus NN cord-317619-o7qfugjw 248 60 infection infection NN cord-317619-o7qfugjw 248 61 in in IN cord-317619-o7qfugjw 248 62 a a DT cord-317619-o7qfugjw 248 63 tropical tropical JJ cord-317619-o7qfugjw 248 64 region region NN cord-317619-o7qfugjw 248 65 Clinical clinical JJ cord-317619-o7qfugjw 248 66 features feature NNS cord-317619-o7qfugjw 248 67 of of IN cord-317619-o7qfugjw 248 68 severe severe JJ cord-317619-o7qfugjw 248 69 influenza influenza NN cord-317619-o7qfugjw 248 70 A a NN cord-317619-o7qfugjw 248 71 ( ( -LRB- cord-317619-o7qfugjw 248 72 H1N1 H1N1 NNP cord-317619-o7qfugjw 248 73 ) ) -RRB- cord-317619-o7qfugjw 248 74 virus virus NN cord-317619-o7qfugjw 248 75 infection infection NN cord-317619-o7qfugjw 248 76 Illness Illness NNP cord-317619-o7qfugjw 248 77 severity severity NN cord-317619-o7qfugjw 248 78 , , , cord-317619-o7qfugjw 248 79 viral viral JJ cord-317619-o7qfugjw 248 80 shedding shedding NN cord-317619-o7qfugjw 248 81 , , , cord-317619-o7qfugjw 248 82 and and CC cord-317619-o7qfugjw 248 83 antibody antibody NN cord-317619-o7qfugjw 248 84 responses response NNS cord-317619-o7qfugjw 248 85 in in IN cord-317619-o7qfugjw 248 86 infants infant NNS cord-317619-o7qfugjw 248 87 hospitalized hospitalize VBN cord-317619-o7qfugjw 248 88 with with IN cord-317619-o7qfugjw 248 89 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 248 90 caused cause VBN cord-317619-o7qfugjw 248 91 by by IN cord-317619-o7qfugjw 248 92 respiratory respiratory JJ cord-317619-o7qfugjw 248 93 syncytial syncytial JJ cord-317619-o7qfugjw 248 94 virus virus NN cord-317619-o7qfugjw 248 95 Type type NN cord-317619-o7qfugjw 248 96 1 1 CD cord-317619-o7qfugjw 248 97 and and CC cord-317619-o7qfugjw 248 98 type type NN cord-317619-o7qfugjw 248 99 2 2 CD cord-317619-o7qfugjw 248 100 cytokine cytokine NN cord-317619-o7qfugjw 248 101 imbalance imbalance NN cord-317619-o7qfugjw 248 102 in in IN cord-317619-o7qfugjw 248 103 acute acute JJ cord-317619-o7qfugjw 248 104 respiratory respiratory JJ cord-317619-o7qfugjw 248 105 syncytial syncytial JJ cord-317619-o7qfugjw 248 106 virus virus NN cord-317619-o7qfugjw 248 107 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 248 108 Respiratory respiratory JJ cord-317619-o7qfugjw 248 109 syncytial syncytial JJ cord-317619-o7qfugjw 248 110 virus virus NN cord-317619-o7qfugjw 248 111 load load NN cord-317619-o7qfugjw 248 112 predicts predict VBZ cord-317619-o7qfugjw 248 113 disease disease NN cord-317619-o7qfugjw 248 114 severity severity NN cord-317619-o7qfugjw 248 115 in in IN cord-317619-o7qfugjw 248 116 previously previously RB cord-317619-o7qfugjw 248 117 healthy healthy JJ cord-317619-o7qfugjw 248 118 infants infant NNS cord-317619-o7qfugjw 248 119 Disease Disease NNP cord-317619-o7qfugjw 248 120 severity severity NN cord-317619-o7qfugjw 248 121 and and CC cord-317619-o7qfugjw 248 122 viral viral JJ cord-317619-o7qfugjw 248 123 load load NN cord-317619-o7qfugjw 248 124 are be VBP cord-317619-o7qfugjw 248 125 correlated correlate VBN cord-317619-o7qfugjw 248 126 in in IN cord-317619-o7qfugjw 248 127 infants infant NNS cord-317619-o7qfugjw 248 128 with with IN cord-317619-o7qfugjw 248 129 primary primary JJ cord-317619-o7qfugjw 248 130 respiratory respiratory JJ cord-317619-o7qfugjw 248 131 syncytial syncytial JJ cord-317619-o7qfugjw 248 132 virus virus NN cord-317619-o7qfugjw 248 133 infection infection NN cord-317619-o7qfugjw 248 134 in in IN cord-317619-o7qfugjw 248 135 the the DT cord-317619-o7qfugjw 248 136 community community NN cord-317619-o7qfugjw 248 137 Respiratory respiratory JJ cord-317619-o7qfugjw 248 138 syncytial syncytial JJ cord-317619-o7qfugjw 248 139 virus virus NN cord-317619-o7qfugjw 248 140 load load NN cord-317619-o7qfugjw 248 141 , , , cord-317619-o7qfugjw 248 142 viral viral JJ cord-317619-o7qfugjw 248 143 dynamics dynamic NNS cord-317619-o7qfugjw 248 144 , , , cord-317619-o7qfugjw 248 145 and and CC cord-317619-o7qfugjw 248 146 disease disease NN cord-317619-o7qfugjw 248 147 severity severity NN cord-317619-o7qfugjw 248 148 in in IN cord-317619-o7qfugjw 248 149 previously previously RB cord-317619-o7qfugjw 248 150 healthy healthy JJ cord-317619-o7qfugjw 248 151 naturally naturally RB cord-317619-o7qfugjw 248 152 infected infect VBN cord-317619-o7qfugjw 248 153 children child NNS cord-317619-o7qfugjw 248 154 Viral viral JJ cord-317619-o7qfugjw 248 155 load load NN cord-317619-o7qfugjw 248 156 at at IN cord-317619-o7qfugjw 248 157 diagnosis diagnosis NN cord-317619-o7qfugjw 248 158 and and CC cord-317619-o7qfugjw 248 159 influenza influenza NN cord-317619-o7qfugjw 248 160 A a DT cord-317619-o7qfugjw 248 161 H1N1 H1N1 NNP cord-317619-o7qfugjw 248 162 ( ( -LRB- cord-317619-o7qfugjw 248 163 2009 2009 CD cord-317619-o7qfugjw 248 164 ) ) -RRB- cord-317619-o7qfugjw 248 165 disease disease NN cord-317619-o7qfugjw 248 166 severity severity NN cord-317619-o7qfugjw 248 167 in in IN cord-317619-o7qfugjw 248 168 children child NNS cord-317619-o7qfugjw 248 169 Correlation correlation NN cord-317619-o7qfugjw 248 170 of of IN cord-317619-o7qfugjw 248 171 pandemic pandemic NN cord-317619-o7qfugjw 248 172 ( ( -LRB- cord-317619-o7qfugjw 248 173 H1N1 H1N1 NNP cord-317619-o7qfugjw 248 174 ) ) -RRB- cord-317619-o7qfugjw 248 175 2009 2009 CD cord-317619-o7qfugjw 248 176 viral viral JJ cord-317619-o7qfugjw 248 177 load load NN cord-317619-o7qfugjw 248 178 with with IN cord-317619-o7qfugjw 248 179 disease disease NN cord-317619-o7qfugjw 248 180 severity severity NN cord-317619-o7qfugjw 248 181 and and CC cord-317619-o7qfugjw 248 182 prolonged prolong VBN cord-317619-o7qfugjw 248 183 viral viral JJ cord-317619-o7qfugjw 248 184 shedding shed VBG cord-317619-o7qfugjw 248 185 in in IN cord-317619-o7qfugjw 248 186 children child NNS cord-317619-o7qfugjw 248 187 Distinct distinct JJ cord-317619-o7qfugjw 248 188 differences difference NNS cord-317619-o7qfugjw 248 189 in in IN cord-317619-o7qfugjw 248 190 clinical clinical JJ cord-317619-o7qfugjw 248 191 manifestation manifestation NN cord-317619-o7qfugjw 248 192 and and CC cord-317619-o7qfugjw 248 193 viral viral JJ cord-317619-o7qfugjw 248 194 laboratory laboratory NN cord-317619-o7qfugjw 248 195 parameters parameter NNS cord-317619-o7qfugjw 248 196 between between IN cord-317619-o7qfugjw 248 197 children child NNS cord-317619-o7qfugjw 248 198 and and CC cord-317619-o7qfugjw 248 199 adults adult NNS cord-317619-o7qfugjw 248 200 with with IN cord-317619-o7qfugjw 248 201 influenza influenza NN cord-317619-o7qfugjw 248 202 A(H1N1 a(h1n1 CD cord-317619-o7qfugjw 248 203 ) ) -RRB- cord-317619-o7qfugjw 249 1 pdm09 pdm09 NFP cord-317619-o7qfugjw 249 2 infection infection NN cord-317619-o7qfugjw 250 1 -a -a : cord-317619-o7qfugjw 250 2 retrospective retrospective JJ cord-317619-o7qfugjw 250 3 comparative comparative JJ cord-317619-o7qfugjw 250 4 analysis analysis NN cord-317619-o7qfugjw 251 1 Acute acute JJ cord-317619-o7qfugjw 251 2 respiratory respiratory JJ cord-317619-o7qfugjw 251 3 distress distress NN cord-317619-o7qfugjw 251 4 syndrome syndrome NN cord-317619-o7qfugjw 251 5 caused cause VBN cord-317619-o7qfugjw 251 6 by by IN cord-317619-o7qfugjw 251 7 respiratory respiratory JJ cord-317619-o7qfugjw 251 8 syncytial syncytial JJ cord-317619-o7qfugjw 251 9 virus virus NN cord-317619-o7qfugjw 251 10 Viral viral JJ cord-317619-o7qfugjw 251 11 and and CC cord-317619-o7qfugjw 251 12 host host NN cord-317619-o7qfugjw 251 13 factors factor NNS cord-317619-o7qfugjw 251 14 in in IN cord-317619-o7qfugjw 251 15 human human JJ cord-317619-o7qfugjw 251 16 respiratory respiratory JJ cord-317619-o7qfugjw 251 17 syncytial syncytial JJ cord-317619-o7qfugjw 251 18 virus virus NN cord-317619-o7qfugjw 251 19 pathogenesis pathogenesis NN cord-317619-o7qfugjw 251 20 Respiratory respiratory JJ cord-317619-o7qfugjw 251 21 syncytial syncytial JJ cord-317619-o7qfugjw 251 22 virus virus NN cord-317619-o7qfugjw 251 23 : : : cord-317619-o7qfugjw 251 24 virology virology NN cord-317619-o7qfugjw 251 25 , , , cord-317619-o7qfugjw 251 26 reverse reverse VB cord-317619-o7qfugjw 251 27 genetics genetic NNS cord-317619-o7qfugjw 251 28 , , , cord-317619-o7qfugjw 251 29 and and CC cord-317619-o7qfugjw 251 30 pathogenesis pathogenesis NN cord-317619-o7qfugjw 251 31 of of IN cord-317619-o7qfugjw 251 32 disease disease NN cord-317619-o7qfugjw 252 1 The the DT cord-317619-o7qfugjw 252 2 histopathology histopathology NN cord-317619-o7qfugjw 252 3 of of IN cord-317619-o7qfugjw 252 4 fatal fatal JJ cord-317619-o7qfugjw 252 5 untreated untreated JJ cord-317619-o7qfugjw 252 6 human human JJ cord-317619-o7qfugjw 252 7 respiratory respiratory JJ cord-317619-o7qfugjw 252 8 syncytial syncytial JJ cord-317619-o7qfugjw 252 9 virus virus NN cord-317619-o7qfugjw 252 10 infection infection NN cord-317619-o7qfugjw 253 1 In in IN cord-317619-o7qfugjw 253 2 vitro vitro FW cord-317619-o7qfugjw 253 3 modeling modeling NN cord-317619-o7qfugjw 253 4 of of IN cord-317619-o7qfugjw 253 5 respiratory respiratory JJ cord-317619-o7qfugjw 253 6 syncytial syncytial JJ cord-317619-o7qfugjw 253 7 virus virus NN cord-317619-o7qfugjw 253 8 infection infection NN cord-317619-o7qfugjw 253 9 of of IN cord-317619-o7qfugjw 253 10 pediatric pediatric JJ cord-317619-o7qfugjw 253 11 bronchial bronchial JJ cord-317619-o7qfugjw 253 12 epithelium epithelium NN cord-317619-o7qfugjw 253 13 , , , cord-317619-o7qfugjw 253 14 the the DT cord-317619-o7qfugjw 253 15 primary primary JJ cord-317619-o7qfugjw 253 16 target target NN cord-317619-o7qfugjw 253 17 of of IN cord-317619-o7qfugjw 253 18 infection infection NN cord-317619-o7qfugjw 253 19 in in IN cord-317619-o7qfugjw 253 20 vivo vivo NNP cord-317619-o7qfugjw 253 21 Novel novel JJ cord-317619-o7qfugjw 253 22 pathways pathway NNS cord-317619-o7qfugjw 253 23 in in IN cord-317619-o7qfugjw 253 24 the the DT cord-317619-o7qfugjw 253 25 pathogenesis pathogenesis NN cord-317619-o7qfugjw 253 26 of of IN cord-317619-o7qfugjw 253 27 respiratory respiratory JJ cord-317619-o7qfugjw 253 28 syncytial syncytial JJ cord-317619-o7qfugjw 253 29 virus virus NN cord-317619-o7qfugjw 253 30 disease disease NN cord-317619-o7qfugjw 253 31 Surfactant Surfactant NNP cord-317619-o7qfugjw 253 32 abnormalities abnormality NNS cord-317619-o7qfugjw 253 33 in in IN cord-317619-o7qfugjw 253 34 infants infant NNS cord-317619-o7qfugjw 253 35 with with IN cord-317619-o7qfugjw 253 36 severe severe JJ cord-317619-o7qfugjw 253 37 viral viral JJ cord-317619-o7qfugjw 253 38 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 253 39 Biomarkers Biomarkers NNPS cord-317619-o7qfugjw 253 40 in in IN cord-317619-o7qfugjw 253 41 pediatric pediatric JJ cord-317619-o7qfugjw 253 42 ARDS ARDS NNP cord-317619-o7qfugjw 253 43 : : : cord-317619-o7qfugjw 253 44 future future JJ cord-317619-o7qfugjw 253 45 directions direction NNS cord-317619-o7qfugjw 253 46 Matrix Matrix NNP cord-317619-o7qfugjw 253 47 metalloproteinase metalloproteinase NN cord-317619-o7qfugjw 253 48 activity activity NN cord-317619-o7qfugjw 253 49 in in IN cord-317619-o7qfugjw 253 50 pediatric pediatric JJ cord-317619-o7qfugjw 253 51 acute acute JJ cord-317619-o7qfugjw 253 52 lung lung NN cord-317619-o7qfugjw 253 53 injury injury NN cord-317619-o7qfugjw 253 54 Matrix Matrix NNP cord-317619-o7qfugjw 253 55 metalloproteinase-9 metalloproteinase-9 NNP cord-317619-o7qfugjw 253 56 mediates mediate VBZ cord-317619-o7qfugjw 253 57 RSV RSV NNP cord-317619-o7qfugjw 253 58 infection infection NN cord-317619-o7qfugjw 253 59 in in IN cord-317619-o7qfugjw 253 60 vitro vitro FW cord-317619-o7qfugjw 253 61 and and CC cord-317619-o7qfugjw 253 62 in in IN cord-317619-o7qfugjw 253 63 vivo vivo NNP cord-317619-o7qfugjw 253 64 Novel novel JJ cord-317619-o7qfugjw 253 65 inflammatory inflammatory JJ cord-317619-o7qfugjw 253 66 markers marker NNS cord-317619-o7qfugjw 253 67 , , , cord-317619-o7qfugjw 253 68 clinical clinical JJ cord-317619-o7qfugjw 253 69 risk risk NN cord-317619-o7qfugjw 253 70 factors factor NNS cord-317619-o7qfugjw 253 71 and and CC cord-317619-o7qfugjw 253 72 virus virus NN cord-317619-o7qfugjw 253 73 type type NN cord-317619-o7qfugjw 253 74 associated associate VBN cord-317619-o7qfugjw 253 75 with with IN cord-317619-o7qfugjw 253 76 severe severe JJ cord-317619-o7qfugjw 253 77 respiratory respiratory JJ cord-317619-o7qfugjw 253 78 syncytial syncytial JJ cord-317619-o7qfugjw 253 79 virus virus NN cord-317619-o7qfugjw 253 80 infection infection NN cord-317619-o7qfugjw 253 81 Plasma Plasma NNP cord-317619-o7qfugjw 253 82 interferon interferon NN cord-317619-o7qfugjw 253 83 - - HYPH cord-317619-o7qfugjw 253 84 gamma gamma NN cord-317619-o7qfugjw 253 85 , , , cord-317619-o7qfugjw 253 86 interleukin-10 interleukin-10 NN cord-317619-o7qfugjw 253 87 and and CC cord-317619-o7qfugjw 253 88 soluble soluble JJ cord-317619-o7qfugjw 253 89 markers marker NNS cord-317619-o7qfugjw 253 90 of of IN cord-317619-o7qfugjw 253 91 immune immune JJ cord-317619-o7qfugjw 253 92 activation activation NN cord-317619-o7qfugjw 253 93 in in IN cord-317619-o7qfugjw 253 94 infants infant NNS cord-317619-o7qfugjw 253 95 with with IN cord-317619-o7qfugjw 253 96 primary primary JJ cord-317619-o7qfugjw 253 97 adenovirus adenovirus NN cord-317619-o7qfugjw 253 98 ( ( -LRB- cord-317619-o7qfugjw 253 99 ADV ADV NNP cord-317619-o7qfugjw 253 100 ) ) -RRB- cord-317619-o7qfugjw 253 101 and and CC cord-317619-o7qfugjw 253 102 respiratory respiratory JJ cord-317619-o7qfugjw 253 103 syncytial syncytial JJ cord-317619-o7qfugjw 253 104 virus virus NN cord-317619-o7qfugjw 253 105 ( ( -LRB- cord-317619-o7qfugjw 253 106 RSV RSV NNP cord-317619-o7qfugjw 253 107 ) ) -RRB- cord-317619-o7qfugjw 253 108 infection infection NN cord-317619-o7qfugjw 253 109 Correlation correlation NN cord-317619-o7qfugjw 253 110 between between IN cord-317619-o7qfugjw 253 111 inflammatory inflammatory JJ cord-317619-o7qfugjw 253 112 mediators mediator NNS cord-317619-o7qfugjw 253 113 in in IN cord-317619-o7qfugjw 253 114 the the DT cord-317619-o7qfugjw 253 115 nasopharyngeal nasopharyngeal JJ cord-317619-o7qfugjw 253 116 secretion secretion NN cord-317619-o7qfugjw 253 117 and and CC cord-317619-o7qfugjw 253 118 in in IN cord-317619-o7qfugjw 253 119 the the DT cord-317619-o7qfugjw 253 120 serum serum NN cord-317619-o7qfugjw 253 121 of of IN cord-317619-o7qfugjw 253 122 children child NNS cord-317619-o7qfugjw 253 123 with with IN cord-317619-o7qfugjw 253 124 lower low JJR cord-317619-o7qfugjw 253 125 respiratory respiratory JJ cord-317619-o7qfugjw 253 126 tract tract NN cord-317619-o7qfugjw 253 127 infection infection NN cord-317619-o7qfugjw 253 128 caused cause VBN cord-317619-o7qfugjw 253 129 by by IN cord-317619-o7qfugjw 253 130 respiratory respiratory JJ cord-317619-o7qfugjw 253 131 syncytial syncytial JJ cord-317619-o7qfugjw 253 132 virus virus NN cord-317619-o7qfugjw 253 133 and and CC cord-317619-o7qfugjw 253 134 disease disease NN cord-317619-o7qfugjw 253 135 severity severity NN cord-317619-o7qfugjw 254 1 Molecular molecular JJ cord-317619-o7qfugjw 254 2 character character NN cord-317619-o7qfugjw 254 3 of of IN cord-317619-o7qfugjw 254 4 influenza influenza NN cord-317619-o7qfugjw 254 5 A A NNP cord-317619-o7qfugjw 254 6 / / SYM cord-317619-o7qfugjw 254 7 H1N1 H1N1 NNP cord-317619-o7qfugjw 254 8 2009 2009 CD cord-317619-o7qfugjw 254 9 : : : cord-317619-o7qfugjw 254 10 implications implication NNS cord-317619-o7qfugjw 254 11 for for IN cord-317619-o7qfugjw 254 12 spread spread NN cord-317619-o7qfugjw 254 13 and and CC cord-317619-o7qfugjw 254 14 control control VB cord-317619-o7qfugjw 254 15 Evolution evolution NN cord-317619-o7qfugjw 254 16 and and CC cord-317619-o7qfugjw 254 17 ecology ecology NN cord-317619-o7qfugjw 254 18 of of IN cord-317619-o7qfugjw 254 19 influenza influenza NN cord-317619-o7qfugjw 254 20 A a NN cord-317619-o7qfugjw 254 21 viruses virus NNS cord-317619-o7qfugjw 254 22 Adaptation Adaptation NNP cord-317619-o7qfugjw 254 23 of of IN cord-317619-o7qfugjw 254 24 avian avian JJ cord-317619-o7qfugjw 254 25 influenza influenza NN cord-317619-o7qfugjw 254 26 A a DT cord-317619-o7qfugjw 254 27 virus virus NN cord-317619-o7qfugjw 254 28 polymerase polymerase NN cord-317619-o7qfugjw 254 29 in in IN cord-317619-o7qfugjw 254 30 mammals mammal NNS cord-317619-o7qfugjw 254 31 to to TO cord-317619-o7qfugjw 254 32 overcome overcome VB cord-317619-o7qfugjw 255 1 the the DT cord-317619-o7qfugjw 255 2 host host NN cord-317619-o7qfugjw 255 3 species specie NNS cord-317619-o7qfugjw 255 4 barrier barrier NN cord-317619-o7qfugjw 256 1 The the DT cord-317619-o7qfugjw 256 2 pig pig NN cord-317619-o7qfugjw 256 3 as as IN cord-317619-o7qfugjw 256 4 a a DT cord-317619-o7qfugjw 256 5 mixing mix VBG cord-317619-o7qfugjw 256 6 vessel vessel NN cord-317619-o7qfugjw 256 7 for for IN cord-317619-o7qfugjw 256 8 influenza influenza NN cord-317619-o7qfugjw 256 9 viruses virus NNS cord-317619-o7qfugjw 256 10 : : : cord-317619-o7qfugjw 256 11 human human JJ cord-317619-o7qfugjw 256 12 and and CC cord-317619-o7qfugjw 256 13 veterinary veterinary JJ cord-317619-o7qfugjw 256 14 implications implication NNS cord-317619-o7qfugjw 256 15 Updating update VBG cord-317619-o7qfugjw 256 16 the the DT cord-317619-o7qfugjw 256 17 accounts account NNS cord-317619-o7qfugjw 256 18 : : : cord-317619-o7qfugjw 256 19 global global JJ cord-317619-o7qfugjw 256 20 mortality mortality NN cord-317619-o7qfugjw 256 21 of of IN cord-317619-o7qfugjw 256 22 the the DT cord-317619-o7qfugjw 256 23 1918 1918 CD cord-317619-o7qfugjw 256 24 - - SYM cord-317619-o7qfugjw 256 25 1920 1920 CD cord-317619-o7qfugjw 256 26 " " `` cord-317619-o7qfugjw 256 27 Spanish spanish JJ cord-317619-o7qfugjw 256 28 " " '' cord-317619-o7qfugjw 256 29 influenza influenza NN cord-317619-o7qfugjw 256 30 pandemic pandemic NN cord-317619-o7qfugjw 256 31 Swine Swine NNP cord-317619-o7qfugjw 256 32 influenza influenza NN cord-317619-o7qfugjw 256 33 a a DT cord-317619-o7qfugjw 256 34 outbreak outbreak NN cord-317619-o7qfugjw 256 35 Swine Swine NNP cord-317619-o7qfugjw 256 36 influenza influenza NN cord-317619-o7qfugjw 256 37 A a NN cord-317619-o7qfugjw 256 38 ( ( -LRB- cord-317619-o7qfugjw 256 39 H1N1 H1N1 NNP cord-317619-o7qfugjw 256 40 ) ) -RRB- cord-317619-o7qfugjw 256 41 infection infection NN cord-317619-o7qfugjw 256 42 in in IN cord-317619-o7qfugjw 256 43 two two CD cord-317619-o7qfugjw 256 44 children child NNS cord-317619-o7qfugjw 256 45 -Southern -Southern -LRB- cord-317619-o7qfugjw 256 46 California California NNP cord-317619-o7qfugjw 256 47 Differential Differential NNP cord-317619-o7qfugjw 256 48 susceptibilities susceptibility NNS cord-317619-o7qfugjw 256 49 of of IN cord-317619-o7qfugjw 256 50 human human JJ cord-317619-o7qfugjw 256 51 lung lung NN cord-317619-o7qfugjw 256 52 primary primary NN cord-317619-o7qfugjw 256 53 cells cell NNS cord-317619-o7qfugjw 256 54 to to IN cord-317619-o7qfugjw 256 55 H1N1 H1N1 NNP cord-317619-o7qfugjw 256 56 influenza influenza NN cord-317619-o7qfugjw 256 57 viruses virus NNS cord-317619-o7qfugjw 256 58 pandemic pandemic VBP cord-317619-o7qfugjw 256 59 influenza influenza NN cord-317619-o7qfugjw 256 60 A a NN cord-317619-o7qfugjw 256 61 ( ( -LRB- cord-317619-o7qfugjw 256 62 H1N1 H1N1 NNP cord-317619-o7qfugjw 256 63 ) ) -RRB- cord-317619-o7qfugjw 256 64 : : : cord-317619-o7qfugjw 257 1 pathology pathology NN cord-317619-o7qfugjw 257 2 and and CC cord-317619-o7qfugjw 257 3 pathogenesis pathogenesis NN cord-317619-o7qfugjw 257 4 of of IN cord-317619-o7qfugjw 257 5 100 100 CD cord-317619-o7qfugjw 257 6 fatal fatal JJ cord-317619-o7qfugjw 257 7 cases case NNS cord-317619-o7qfugjw 257 8 in in IN cord-317619-o7qfugjw 257 9 the the DT cord-317619-o7qfugjw 257 10 United United NNP cord-317619-o7qfugjw 257 11 States States NNP cord-317619-o7qfugjw 257 12 Pneumonia Pneumonia NNP cord-317619-o7qfugjw 257 13 and and CC cord-317619-o7qfugjw 257 14 respiratory respiratory JJ cord-317619-o7qfugjw 257 15 failure failure NN cord-317619-o7qfugjw 257 16 from from IN cord-317619-o7qfugjw 257 17 swine swine NN cord-317619-o7qfugjw 257 18 - - HYPH cord-317619-o7qfugjw 257 19 origin origin NN cord-317619-o7qfugjw 257 20 influenza influenza NN cord-317619-o7qfugjw 257 21 A A NNP cord-317619-o7qfugjw 257 22 ( ( -LRB- cord-317619-o7qfugjw 257 23 H1N1 H1N1 NNP cord-317619-o7qfugjw 257 24 ) ) -RRB- cord-317619-o7qfugjw 257 25 in in IN cord-317619-o7qfugjw 257 26 Mexico Mexico NNP cord-317619-o7qfugjw 257 27 Influenza Influenza NNP cord-317619-o7qfugjw 257 28 virus virus NN cord-317619-o7qfugjw 257 29 pathogenicity pathogenicity NN cord-317619-o7qfugjw 257 30 regulated regulate VBN cord-317619-o7qfugjw 257 31 by by IN cord-317619-o7qfugjw 257 32 host host NN cord-317619-o7qfugjw 257 33 cellular cellular JJ cord-317619-o7qfugjw 257 34 proteases protease NNS cord-317619-o7qfugjw 257 35 , , , cord-317619-o7qfugjw 257 36 cytokines cytokine NNS cord-317619-o7qfugjw 257 37 and and CC cord-317619-o7qfugjw 257 38 metabolites metabolite NNS cord-317619-o7qfugjw 257 39 , , , cord-317619-o7qfugjw 257 40 and and CC cord-317619-o7qfugjw 257 41 its -PRON- PRP$ cord-317619-o7qfugjw 257 42 therapeutic therapeutic JJ cord-317619-o7qfugjw 257 43 options option NNS cord-317619-o7qfugjw 257 44 Three three CD cord-317619-o7qfugjw 257 45 fatal fatal JJ cord-317619-o7qfugjw 257 46 cases case NNS cord-317619-o7qfugjw 257 47 of of IN cord-317619-o7qfugjw 257 48 pandemic pandemic NN cord-317619-o7qfugjw 257 49 2009 2009 CD cord-317619-o7qfugjw 257 50 influenza influenza NN cord-317619-o7qfugjw 257 51 A a DT cord-317619-o7qfugjw 257 52 virus virus NN cord-317619-o7qfugjw 257 53 infection infection NN cord-317619-o7qfugjw 257 54 in in IN cord-317619-o7qfugjw 257 55 Shenzhen Shenzhen NNP cord-317619-o7qfugjw 257 56 are be VBP cord-317619-o7qfugjw 257 57 associated associate VBN cord-317619-o7qfugjw 257 58 with with IN cord-317619-o7qfugjw 257 59 cytokine cytokine NN cord-317619-o7qfugjw 257 60 storm storm NN cord-317619-o7qfugjw 257 61 Antibody Antibody NNP cord-317619-o7qfugjw 257 62 and and CC cord-317619-o7qfugjw 257 63 inflammatory inflammatory JJ cord-317619-o7qfugjw 257 64 response response NN cord-317619-o7qfugjw 257 65 - - HYPH cord-317619-o7qfugjw 257 66 mediated mediate VBN cord-317619-o7qfugjw 257 67 severity severity NN cord-317619-o7qfugjw 257 68 of of IN cord-317619-o7qfugjw 257 69 pandemic pandemic NN cord-317619-o7qfugjw 257 70 2009 2009 CD cord-317619-o7qfugjw 257 71 ( ( -LRB- cord-317619-o7qfugjw 257 72 pH1N1 pH1N1 NNP cord-317619-o7qfugjw 257 73 ) ) -RRB- cord-317619-o7qfugjw 258 1 influenza influenza NN cord-317619-o7qfugjw 258 2 virus virus NN cord-317619-o7qfugjw 258 3 Cytokine cytokine NN cord-317619-o7qfugjw 258 4 and and CC cord-317619-o7qfugjw 258 5 chemokine chemokine NN cord-317619-o7qfugjw 258 6 response response NN cord-317619-o7qfugjw 258 7 in in IN cord-317619-o7qfugjw 258 8 children child NNS cord-317619-o7qfugjw 258 9 with with IN cord-317619-o7qfugjw 258 10 the the DT cord-317619-o7qfugjw 258 11 2009 2009 CD cord-317619-o7qfugjw 258 12 pandemic pandemic NN cord-317619-o7qfugjw 258 13 influenza influenza NN cord-317619-o7qfugjw 258 14 A A NNP cord-317619-o7qfugjw 258 15 ( ( -LRB- cord-317619-o7qfugjw 258 16 H1N1 H1N1 NNP cord-317619-o7qfugjw 258 17 ) ) -RRB- cord-317619-o7qfugjw 258 18 virus virus NN cord-317619-o7qfugjw 258 19 infection infection NN cord-317619-o7qfugjw 258 20 Monocyte Monocyte NNP cord-317619-o7qfugjw 258 21 chemoattractant chemoattractant NN cord-317619-o7qfugjw 258 22 protein protein NN cord-317619-o7qfugjw 258 23 1 1 CD cord-317619-o7qfugjw 258 24 contributes contribute VBZ cord-317619-o7qfugjw 258 25 to to IN cord-317619-o7qfugjw 258 26 an an DT cord-317619-o7qfugjw 258 27 adequate adequate JJ cord-317619-o7qfugjw 258 28 immune immune JJ cord-317619-o7qfugjw 258 29 response response NN cord-317619-o7qfugjw 258 30 in in IN cord-317619-o7qfugjw 258 31 influenza influenza NN cord-317619-o7qfugjw 258 32 pneumonia pneumonia NN cord-317619-o7qfugjw 258 33 Role role NN cord-317619-o7qfugjw 258 34 of of IN cord-317619-o7qfugjw 258 35 inhaled inhale VBN cord-317619-o7qfugjw 258 36 nitric nitric NN cord-317619-o7qfugjw 258 37 oxide oxide NN cord-317619-o7qfugjw 258 38 in in IN cord-317619-o7qfugjw 258 39 the the DT cord-317619-o7qfugjw 258 40 management management NN cord-317619-o7qfugjw 258 41 of of IN cord-317619-o7qfugjw 258 42 severe severe JJ cord-317619-o7qfugjw 258 43 acute acute JJ cord-317619-o7qfugjw 258 44 respiratory respiratory JJ cord-317619-o7qfugjw 258 45 distress distress NN cord-317619-o7qfugjw 258 46 syndrome syndrome NN cord-317619-o7qfugjw 258 47 Comparison comparison NN cord-317619-o7qfugjw 258 48 of of IN cord-317619-o7qfugjw 258 49 two two CD cord-317619-o7qfugjw 258 50 fluid fluid JJ cord-317619-o7qfugjw 258 51 - - HYPH cord-317619-o7qfugjw 258 52 management management NN cord-317619-o7qfugjw 258 53 strategies strategy NNS cord-317619-o7qfugjw 258 54 in in IN cord-317619-o7qfugjw 258 55 acute acute JJ cord-317619-o7qfugjw 258 56 lung lung NN cord-317619-o7qfugjw 258 57 injury injury NN cord-317619-o7qfugjw 258 58 Efficacy Efficacy NNP cord-317619-o7qfugjw 258 59 and and CC cord-317619-o7qfugjw 258 60 safety safety NN cord-317619-o7qfugjw 258 61 of of IN cord-317619-o7qfugjw 258 62 corticosteroids corticosteroid NNS cord-317619-o7qfugjw 258 63 for for IN cord-317619-o7qfugjw 258 64 persistent persistent JJ cord-317619-o7qfugjw 258 65 acute acute JJ cord-317619-o7qfugjw 258 66 respiratory respiratory JJ cord-317619-o7qfugjw 258 67 distress distress NN cord-317619-o7qfugjw 258 68 syndrome syndrome NN cord-317619-o7qfugjw 258 69 Prone prone JJ cord-317619-o7qfugjw 258 70 positioning positioning NN cord-317619-o7qfugjw 258 71 in in IN cord-317619-o7qfugjw 258 72 severe severe JJ cord-317619-o7qfugjw 258 73 acute acute JJ cord-317619-o7qfugjw 258 74 respiratory respiratory JJ cord-317619-o7qfugjw 258 75 distress distress NN cord-317619-o7qfugjw 258 76 syndrome syndrome NN cord-317619-o7qfugjw 258 77 Biological biological JJ cord-317619-o7qfugjw 258 78 challenges challenge NNS cord-317619-o7qfugjw 258 79 and and CC cord-317619-o7qfugjw 258 80 technological technological JJ cord-317619-o7qfugjw 258 81 opportunities opportunity NNS cord-317619-o7qfugjw 258 82 for for IN cord-317619-o7qfugjw 258 83 respiratory respiratory JJ cord-317619-o7qfugjw 258 84 syncytial syncytial JJ cord-317619-o7qfugjw 258 85 virus virus NN cord-317619-o7qfugjw 258 86 vaccine vaccine NN cord-317619-o7qfugjw 258 87 development development NN cord-317619-o7qfugjw 258 88 Phase phase NN cord-317619-o7qfugjw 259 1 -I -i DT cord-317619-o7qfugjw 259 2 study study NN cord-317619-o7qfugjw 259 3 MEDI-534 MEDI-534 NNP cord-317619-o7qfugjw 259 4 , , , cord-317619-o7qfugjw 259 5 of of IN cord-317619-o7qfugjw 259 6 a a DT cord-317619-o7qfugjw 259 7 live live JJ cord-317619-o7qfugjw 259 8 , , , cord-317619-o7qfugjw 259 9 attenuated attenuated JJ cord-317619-o7qfugjw 259 10 intranasal intranasal NN cord-317619-o7qfugjw 259 11 vaccine vaccine NN cord-317619-o7qfugjw 259 12 against against IN cord-317619-o7qfugjw 259 13 respiratory respiratory JJ cord-317619-o7qfugjw 259 14 syncytial syncytial JJ cord-317619-o7qfugjw 259 15 virus virus NN cord-317619-o7qfugjw 259 16 and and CC cord-317619-o7qfugjw 259 17 parainfluenza-3 parainfluenza-3 NNP cord-317619-o7qfugjw 259 18 virus virus NN cord-317619-o7qfugjw 259 19 in in IN cord-317619-o7qfugjw 259 20 seropositive seropositive JJ cord-317619-o7qfugjw 259 21 children child NNS cord-317619-o7qfugjw 260 1 Live live VB cord-317619-o7qfugjw 260 2 - - HYPH cord-317619-o7qfugjw 260 3 attenuated attenuated JJ cord-317619-o7qfugjw 260 4 respiratory respiratory JJ cord-317619-o7qfugjw 260 5 syncytial syncytial JJ cord-317619-o7qfugjw 260 6 virus virus NN cord-317619-o7qfugjw 261 1 vaccines vaccine NNS cord-317619-o7qfugjw 261 2 A a DT cord-317619-o7qfugjw 261 3 gene gene NN cord-317619-o7qfugjw 261 4 deletion deletion NN cord-317619-o7qfugjw 261 5 that that IN cord-317619-o7qfugjw 261 6 up up RB cord-317619-o7qfugjw 261 7 - - HYPH cord-317619-o7qfugjw 261 8 regulates regulate VBZ cord-317619-o7qfugjw 261 9 viral viral JJ cord-317619-o7qfugjw 261 10 gene gene NN cord-317619-o7qfugjw 261 11 expression expression NN cord-317619-o7qfugjw 261 12 yields yield VBZ cord-317619-o7qfugjw 261 13 an an DT cord-317619-o7qfugjw 261 14 attenuated attenuated JJ cord-317619-o7qfugjw 261 15 RSV RSV NNP cord-317619-o7qfugjw 261 16 vaccine vaccine NN cord-317619-o7qfugjw 261 17 with with IN cord-317619-o7qfugjw 261 18 improved improved JJ cord-317619-o7qfugjw 261 19 antibody antibody NN cord-317619-o7qfugjw 261 20 responses response NNS cord-317619-o7qfugjw 261 21 in in IN cord-317619-o7qfugjw 261 22 children child NNS cord-317619-o7qfugjw 261 23 Enhanced enhance VBN cord-317619-o7qfugjw 261 24 neutralizing neutralize VBG cord-317619-o7qfugjw 261 25 antibody antibody NN cord-317619-o7qfugjw 261 26 response response NN cord-317619-o7qfugjw 261 27 induced induce VBN cord-317619-o7qfugjw 261 28 by by IN cord-317619-o7qfugjw 261 29 respiratory respiratory JJ cord-317619-o7qfugjw 261 30 syncytial syncytial JJ cord-317619-o7qfugjw 261 31 virus virus NN cord-317619-o7qfugjw 261 32 prefusion prefusion NNP cord-317619-o7qfugjw 261 33 F F NNP cord-317619-o7qfugjw 261 34 protein protein NN cord-317619-o7qfugjw 261 35 expressed express VBN cord-317619-o7qfugjw 261 36 by by IN cord-317619-o7qfugjw 261 37 a a DT cord-317619-o7qfugjw 261 38 vaccine vaccine NN cord-317619-o7qfugjw 261 39 candidate candidate NN cord-317619-o7qfugjw 261 40 Antibodies Antibodies NNP cord-317619-o7qfugjw 261 41 for for IN cord-317619-o7qfugjw 261 42 prevention prevention NN cord-317619-o7qfugjw 261 43 and and CC cord-317619-o7qfugjw 261 44 treatment treatment NN cord-317619-o7qfugjw 261 45 of of IN cord-317619-o7qfugjw 261 46 respiratory respiratory JJ cord-317619-o7qfugjw 261 47 syncytial syncytial JJ cord-317619-o7qfugjw 261 48 virus virus NN cord-317619-o7qfugjw 261 49 infections infection NNS cord-317619-o7qfugjw 261 50 in in IN cord-317619-o7qfugjw 261 51 children child NNS cord-317619-o7qfugjw 261 52 Development Development NNP cord-317619-o7qfugjw 261 53 of of IN cord-317619-o7qfugjw 261 54 a a DT cord-317619-o7qfugjw 261 55 humanized humanize VBN cord-317619-o7qfugjw 261 56 monoclonal monoclonal JJ cord-317619-o7qfugjw 261 57 antibody antibody NN cord-317619-o7qfugjw 261 58 ( ( -LRB- cord-317619-o7qfugjw 261 59 MEDI-493 MEDI-493 NNP cord-317619-o7qfugjw 261 60 ) ) -RRB- cord-317619-o7qfugjw 261 61 with with IN cord-317619-o7qfugjw 261 62 potent potent JJ cord-317619-o7qfugjw 261 63 in in IN cord-317619-o7qfugjw 261 64 vitro vitro FW cord-317619-o7qfugjw 261 65 and and CC cord-317619-o7qfugjw 261 66 in in IN cord-317619-o7qfugjw 261 67 vivo vivo NN cord-317619-o7qfugjw 261 68 activity activity NN cord-317619-o7qfugjw 261 69 against against IN cord-317619-o7qfugjw 261 70 respiratory respiratory JJ cord-317619-o7qfugjw 261 71 syncytial syncytial JJ cord-317619-o7qfugjw 261 72 virus virus NN cord-317619-o7qfugjw 261 73 Effectiveness Effectiveness NNP cord-317619-o7qfugjw 261 74 of of IN cord-317619-o7qfugjw 261 75 palivizumab palivizumab NNS cord-317619-o7qfugjw 261 76 in in IN cord-317619-o7qfugjw 261 77 preventing prevent VBG cord-317619-o7qfugjw 261 78 RSV RSV NNP cord-317619-o7qfugjw 261 79 hospitalization hospitalization NN cord-317619-o7qfugjw 261 80 in in IN cord-317619-o7qfugjw 261 81 high high JJ cord-317619-o7qfugjw 261 82 risk risk NN cord-317619-o7qfugjw 261 83 children child NNS cord-317619-o7qfugjw 261 84 : : : cord-317619-o7qfugjw 261 85 a a DT cord-317619-o7qfugjw 261 86 real real JJ cord-317619-o7qfugjw 261 87 - - HYPH cord-317619-o7qfugjw 261 88 world world NN cord-317619-o7qfugjw 261 89 perspective perspective NN cord-317619-o7qfugjw 261 90 Comparison comparison NN cord-317619-o7qfugjw 261 91 of of IN cord-317619-o7qfugjw 261 92 intravenous intravenous JJ cord-317619-o7qfugjw 261 93 palivizumab palivizumab NNS cord-317619-o7qfugjw 261 94 and and CC cord-317619-o7qfugjw 261 95 standard standard NN cord-317619-o7qfugjw 261 96 of of IN cord-317619-o7qfugjw 261 97 care care NN cord-317619-o7qfugjw 261 98 for for IN cord-317619-o7qfugjw 261 99 treatment treatment NN cord-317619-o7qfugjw 261 100 of of IN cord-317619-o7qfugjw 261 101 respiratory respiratory JJ cord-317619-o7qfugjw 261 102 syncytial syncytial JJ cord-317619-o7qfugjw 261 103 virus virus NN cord-317619-o7qfugjw 261 104 infection infection NN cord-317619-o7qfugjw 261 105 in in IN cord-317619-o7qfugjw 261 106 mechanically mechanically RB cord-317619-o7qfugjw 261 107 ventilated ventilate VBN cord-317619-o7qfugjw 261 108 pediatric pediatric JJ cord-317619-o7qfugjw 261 109 patients patient NNS cord-317619-o7qfugjw 261 110 Impact Impact NNP cord-317619-o7qfugjw 261 111 of of IN cord-317619-o7qfugjw 261 112 palivizumab palivizumab NNS cord-317619-o7qfugjw 261 113 on on IN cord-317619-o7qfugjw 261 114 admission admission NN cord-317619-o7qfugjw 261 115 to to IN cord-317619-o7qfugjw 261 116 the the DT cord-317619-o7qfugjw 261 117 ICU ICU NNP cord-317619-o7qfugjw 261 118 for for IN cord-317619-o7qfugjw 261 119 respiratory respiratory JJ cord-317619-o7qfugjw 261 120 syncytial syncytial JJ cord-317619-o7qfugjw 261 121 virus virus NN cord-317619-o7qfugjw 261 122 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 261 123 : : : cord-317619-o7qfugjw 261 124 a a DT cord-317619-o7qfugjw 261 125 national national JJ cord-317619-o7qfugjw 261 126 survey survey NN cord-317619-o7qfugjw 261 127 Safety safety NN cord-317619-o7qfugjw 261 128 and and CC cord-317619-o7qfugjw 261 129 antiviral antiviral JJ cord-317619-o7qfugjw 261 130 activity activity NN cord-317619-o7qfugjw 261 131 of of IN cord-317619-o7qfugjw 261 132 motavizumab motavizumab NNP cord-317619-o7qfugjw 261 133 , , , cord-317619-o7qfugjw 261 134 a a DT cord-317619-o7qfugjw 261 135 respiratory respiratory JJ cord-317619-o7qfugjw 261 136 syncytial syncytial JJ cord-317619-o7qfugjw 261 137 virus virus NN cord-317619-o7qfugjw 261 138 ( ( -LRB- cord-317619-o7qfugjw 261 139 RSV)-specific rsv)-specific NN cord-317619-o7qfugjw 261 140 humanized humanize VBN cord-317619-o7qfugjw 261 141 monoclonal monoclonal JJ cord-317619-o7qfugjw 261 142 antibody antibody NN cord-317619-o7qfugjw 261 143 , , , cord-317619-o7qfugjw 261 144 when when WRB cord-317619-o7qfugjw 261 145 administered administer VBN cord-317619-o7qfugjw 261 146 to to IN cord-317619-o7qfugjw 261 147 RSV RSV NNP cord-317619-o7qfugjw 261 148 - - HYPH cord-317619-o7qfugjw 261 149 infected infect VBN cord-317619-o7qfugjw 261 150 children child NNS cord-317619-o7qfugjw 262 1 Motavizumab motavizumab JJ cord-317619-o7qfugjw 262 2 treatment treatment NN cord-317619-o7qfugjw 262 3 of of IN cord-317619-o7qfugjw 262 4 infants infant NNS cord-317619-o7qfugjw 262 5 hospitalized hospitalize VBN cord-317619-o7qfugjw 262 6 with with IN cord-317619-o7qfugjw 262 7 respiratory respiratory JJ cord-317619-o7qfugjw 262 8 syncytial syncytial JJ cord-317619-o7qfugjw 262 9 virus virus NN cord-317619-o7qfugjw 262 10 infection infection NN cord-317619-o7qfugjw 262 11 does do VBZ cord-317619-o7qfugjw 262 12 not not RB cord-317619-o7qfugjw 262 13 decrease decrease VB cord-317619-o7qfugjw 262 14 viral viral JJ cord-317619-o7qfugjw 262 15 load load NN cord-317619-o7qfugjw 262 16 or or CC cord-317619-o7qfugjw 262 17 severity severity NN cord-317619-o7qfugjw 262 18 of of IN cord-317619-o7qfugjw 262 19 illness illness NN cord-317619-o7qfugjw 262 20 Safety safety NN cord-317619-o7qfugjw 262 21 and and CC cord-317619-o7qfugjw 262 22 effectiveness effectiveness NN cord-317619-o7qfugjw 262 23 of of IN cord-317619-o7qfugjw 262 24 palivizumab palivizumab NNS cord-317619-o7qfugjw 262 25 in in IN cord-317619-o7qfugjw 262 26 children child NNS cord-317619-o7qfugjw 262 27 at at IN cord-317619-o7qfugjw 262 28 high high JJ cord-317619-o7qfugjw 262 29 risk risk NN cord-317619-o7qfugjw 262 30 of of IN cord-317619-o7qfugjw 262 31 serious serious JJ cord-317619-o7qfugjw 262 32 disease disease NN cord-317619-o7qfugjw 262 33 due due IN cord-317619-o7qfugjw 262 34 to to IN cord-317619-o7qfugjw 262 35 respiratory respiratory JJ cord-317619-o7qfugjw 262 36 syncytial syncytial JJ cord-317619-o7qfugjw 262 37 virus virus NN cord-317619-o7qfugjw 262 38 infection infection NN cord-317619-o7qfugjw 262 39 : : : cord-317619-o7qfugjw 262 40 a a DT cord-317619-o7qfugjw 262 41 systematic systematic JJ cord-317619-o7qfugjw 262 42 review review NN cord-317619-o7qfugjw 262 43 Serum serum NN cord-317619-o7qfugjw 262 44 cross cross JJ cord-317619-o7qfugjw 262 45 - - JJ cord-317619-o7qfugjw 262 46 reactive reactive JJ cord-317619-o7qfugjw 262 47 antibody antibody NN cord-317619-o7qfugjw 262 48 response response NN cord-317619-o7qfugjw 262 49 to to IN cord-317619-o7qfugjw 262 50 a a DT cord-317619-o7qfugjw 262 51 novel novel JJ cord-317619-o7qfugjw 262 52 influenza influenza NN cord-317619-o7qfugjw 262 53 A a NN cord-317619-o7qfugjw 262 54 ( ( -LRB- cord-317619-o7qfugjw 262 55 H1N1 H1N1 NNP cord-317619-o7qfugjw 262 56 ) ) -RRB- cord-317619-o7qfugjw 262 57 virus virus NN cord-317619-o7qfugjw 262 58 after after IN cord-317619-o7qfugjw 262 59 vaccination vaccination NN cord-317619-o7qfugjw 262 60 with with IN cord-317619-o7qfugjw 262 61 seasonal seasonal JJ cord-317619-o7qfugjw 262 62 influenza influenza NN cord-317619-o7qfugjw 262 63 vaccine vaccine NN cord-317619-o7qfugjw 262 64 Safety Safety NNP cord-317619-o7qfugjw 262 65 and and CC cord-317619-o7qfugjw 262 66 immunogenicity immunogenicity NN cord-317619-o7qfugjw 262 67 following follow VBG cord-317619-o7qfugjw 262 68 administration administration NN cord-317619-o7qfugjw 262 69 of of IN cord-317619-o7qfugjw 262 70 a a DT cord-317619-o7qfugjw 262 71 live live JJ cord-317619-o7qfugjw 262 72 , , , cord-317619-o7qfugjw 262 73 attenuated attenuated JJ cord-317619-o7qfugjw 262 74 monovalent monovalent JJ cord-317619-o7qfugjw 262 75 2009 2009 CD cord-317619-o7qfugjw 262 76 H1N1 H1N1 NNP cord-317619-o7qfugjw 262 77 influenza influenza NN cord-317619-o7qfugjw 262 78 vaccine vaccine NN cord-317619-o7qfugjw 262 79 to to IN cord-317619-o7qfugjw 262 80 children child NNS cord-317619-o7qfugjw 262 81 and and CC cord-317619-o7qfugjw 262 82 adults adult NNS cord-317619-o7qfugjw 262 83 in in IN cord-317619-o7qfugjw 262 84 two two CD cord-317619-o7qfugjw 262 85 randomized randomized JJ cord-317619-o7qfugjw 262 86 controlled control VBN cord-317619-o7qfugjw 262 87 trials trial NNS cord-317619-o7qfugjw 263 1 A a DT cord-317619-o7qfugjw 263 2 novel novel JJ cord-317619-o7qfugjw 263 3 influenza influenza NN cord-317619-o7qfugjw 263 4 A a NN cord-317619-o7qfugjw 263 5 ( ( -LRB- cord-317619-o7qfugjw 263 6 H1N1 H1N1 NNP cord-317619-o7qfugjw 263 7 ) ) -RRB- cord-317619-o7qfugjw 263 8 vaccine vaccine NN cord-317619-o7qfugjw 263 9 in in IN cord-317619-o7qfugjw 263 10 various various JJ cord-317619-o7qfugjw 263 11 age age NN cord-317619-o7qfugjw 263 12 groups group NNS cord-317619-o7qfugjw 263 13 Pandemic Pandemic NNP cord-317619-o7qfugjw 263 14 vaccination vaccination NN cord-317619-o7qfugjw 263 15 strategies strategy NNS cord-317619-o7qfugjw 263 16 and and CC cord-317619-o7qfugjw 263 17 influenza influenza NN cord-317619-o7qfugjw 263 18 severe severe JJ cord-317619-o7qfugjw 263 19 outcomes outcome NNS cord-317619-o7qfugjw 263 20 during during IN cord-317619-o7qfugjw 263 21 the the DT cord-317619-o7qfugjw 263 22 influenza influenza NN cord-317619-o7qfugjw 263 23 A(H1N1)pdm09 a(h1n1)pdm09 IN cord-317619-o7qfugjw 263 24 pandemic pandemic NN cord-317619-o7qfugjw 263 25 and and CC cord-317619-o7qfugjw 263 26 the the DT cord-317619-o7qfugjw 263 27 post post JJ cord-317619-o7qfugjw 263 28 - - JJ cord-317619-o7qfugjw 263 29 pandemic pandemic JJ cord-317619-o7qfugjw 263 30 influenza influenza NN cord-317619-o7qfugjw 263 31 season season NN cord-317619-o7qfugjw 263 32 : : : cord-317619-o7qfugjw 263 33 the the DT cord-317619-o7qfugjw 263 34 Nordic nordic JJ cord-317619-o7qfugjw 263 35 experience experience NN cord-317619-o7qfugjw 264 1 A a DT cord-317619-o7qfugjw 264 2 controlled control VBN cord-317619-o7qfugjw 264 3 trial trial NN cord-317619-o7qfugjw 264 4 of of IN cord-317619-o7qfugjw 264 5 aerosolized aerosolize VBN cord-317619-o7qfugjw 264 6 ribavirin ribavirin NN cord-317619-o7qfugjw 264 7 in in IN cord-317619-o7qfugjw 264 8 infants infant NNS cord-317619-o7qfugjw 264 9 receiving receive VBG cord-317619-o7qfugjw 264 10 mechanical mechanical JJ cord-317619-o7qfugjw 264 11 ventilation ventilation NN cord-317619-o7qfugjw 264 12 for for IN cord-317619-o7qfugjw 264 13 severe severe JJ cord-317619-o7qfugjw 264 14 respiratory respiratory JJ cord-317619-o7qfugjw 264 15 syncytial syncytial JJ cord-317619-o7qfugjw 264 16 virus virus NN cord-317619-o7qfugjw 264 17 infection infection NN cord-317619-o7qfugjw 264 18 Safety Safety NNP cord-317619-o7qfugjw 264 19 issues issue NNS cord-317619-o7qfugjw 264 20 related relate VBN cord-317619-o7qfugjw 264 21 to to IN cord-317619-o7qfugjw 264 22 the the DT cord-317619-o7qfugjw 264 23 administration administration NN cord-317619-o7qfugjw 264 24 of of IN cord-317619-o7qfugjw 264 25 ribavirin ribavirin NNP cord-317619-o7qfugjw 264 26 Broad Broad NNP cord-317619-o7qfugjw 264 27 - - HYPH cord-317619-o7qfugjw 264 28 spectrum spectrum NN cord-317619-o7qfugjw 264 29 antiviral antiviral JJ cord-317619-o7qfugjw 264 30 activity activity NN cord-317619-o7qfugjw 264 31 of of IN cord-317619-o7qfugjw 264 32 Virazole Virazole NNP cord-317619-o7qfugjw 264 33 : : : cord-317619-o7qfugjw 264 34 1-beta 1-beta CD cord-317619-o7qfugjw 264 35 - - HYPH cord-317619-o7qfugjw 264 36 d- d- XX cord-317619-o7qfugjw 265 1 ribofuranosyl-1,2,4-triazole-3-carboxamide ribofuranosyl-1,2,4-triazole-3-carboxamide NNP cord-317619-o7qfugjw 265 2 Ribavirin ribavirin RB cord-317619-o7qfugjw 265 3 for for IN cord-317619-o7qfugjw 265 4 respiratory respiratory JJ cord-317619-o7qfugjw 265 5 syncytial syncytial JJ cord-317619-o7qfugjw 265 6 virus virus NN cord-317619-o7qfugjw 265 7 infection infection NN cord-317619-o7qfugjw 265 8 of of IN cord-317619-o7qfugjw 265 9 the the DT cord-317619-o7qfugjw 265 10 lower low JJR cord-317619-o7qfugjw 265 11 respiratory respiratory JJ cord-317619-o7qfugjw 265 12 tract tract NN cord-317619-o7qfugjw 265 13 in in IN cord-317619-o7qfugjw 265 14 infants infant NNS cord-317619-o7qfugjw 265 15 and and CC cord-317619-o7qfugjw 265 16 young young JJ cord-317619-o7qfugjw 265 17 children child NNS cord-317619-o7qfugjw 265 18 Inhaled inhale VBD cord-317619-o7qfugjw 265 19 ribavirin ribavirin NN cord-317619-o7qfugjw 265 20 therapy therapy NN cord-317619-o7qfugjw 265 21 in in IN cord-317619-o7qfugjw 265 22 adult adult JJ cord-317619-o7qfugjw 265 23 respiratory respiratory JJ cord-317619-o7qfugjw 265 24 syncytial syncytial JJ cord-317619-o7qfugjw 265 25 virus virus NN cord-317619-o7qfugjw 265 26 - - HYPH cord-317619-o7qfugjw 265 27 induced induce VBN cord-317619-o7qfugjw 265 28 acute acute JJ cord-317619-o7qfugjw 265 29 respiratory respiratory JJ cord-317619-o7qfugjw 265 30 distress distress NN cord-317619-o7qfugjw 265 31 syndrome syndrome NN cord-317619-o7qfugjw 265 32 Virological virological JJ cord-317619-o7qfugjw 265 33 clearance clearance NN cord-317619-o7qfugjw 265 34 rate rate NN cord-317619-o7qfugjw 265 35 of of IN cord-317619-o7qfugjw 265 36 high high JJ cord-317619-o7qfugjw 265 37 - - HYPH cord-317619-o7qfugjw 265 38 dose dose NN cord-317619-o7qfugjw 265 39 oseltamivir oseltamivir NNS cord-317619-o7qfugjw 265 40 or or CC cord-317619-o7qfugjw 265 41 triple triple JJ cord-317619-o7qfugjw 265 42 - - HYPH cord-317619-o7qfugjw 265 43 combination combination NN cord-317619-o7qfugjw 265 44 antiviral antiviral JJ cord-317619-o7qfugjw 265 45 therapy therapy NN cord-317619-o7qfugjw 265 46 in in IN cord-317619-o7qfugjw 265 47 complicated complicated JJ cord-317619-o7qfugjw 265 48 2009 2009 CD cord-317619-o7qfugjw 265 49 pandemic pandemic NN cord-317619-o7qfugjw 265 50 influenza influenza NN cord-317619-o7qfugjw 265 51 A A NNP cord-317619-o7qfugjw 265 52 ( ( -LRB- cord-317619-o7qfugjw 265 53 H1N1 H1N1 NNP cord-317619-o7qfugjw 265 54 ) ) -RRB- cord-317619-o7qfugjw 265 55 infection infection NN cord-317619-o7qfugjw 265 56 Respiratory respiratory JJ cord-317619-o7qfugjw 265 57 syncytial syncytial JJ cord-317619-o7qfugjw 265 58 virus virus NN cord-317619-o7qfugjw 265 59 Small small JJ cord-317619-o7qfugjw 265 60 molecules molecule NNS cord-317619-o7qfugjw 266 1 VP-14637 VP-14637 NNP cord-317619-o7qfugjw 266 2 and and CC cord-317619-o7qfugjw 266 3 JNJ-2408068 JNJ-2408068 NNP cord-317619-o7qfugjw 266 4 inhibit inhibit VBP cord-317619-o7qfugjw 266 5 respiratory respiratory JJ cord-317619-o7qfugjw 266 6 syncytial syncytial JJ cord-317619-o7qfugjw 266 7 virus virus NN cord-317619-o7qfugjw 266 8 fusion fusion NN cord-317619-o7qfugjw 266 9 by by IN cord-317619-o7qfugjw 266 10 similar similar JJ cord-317619-o7qfugjw 266 11 mechanisms mechanism NNS cord-317619-o7qfugjw 266 12 Oral oral JJ cord-317619-o7qfugjw 266 13 GS-5806 GS-5806 VBN cord-317619-o7qfugjw 266 14 activity activity NN cord-317619-o7qfugjw 266 15 in in IN cord-317619-o7qfugjw 266 16 a a DT cord-317619-o7qfugjw 266 17 respiratory respiratory JJ cord-317619-o7qfugjw 266 18 syncytial syncytial JJ cord-317619-o7qfugjw 266 19 virus virus NN cord-317619-o7qfugjw 266 20 challenge challenge NN cord-317619-o7qfugjw 266 21 study study NN cord-317619-o7qfugjw 266 22 Use Use NNP cord-317619-o7qfugjw 266 23 of of IN cord-317619-o7qfugjw 266 24 the the DT cord-317619-o7qfugjw 266 25 oral oral JJ cord-317619-o7qfugjw 266 26 neuraminidase neuraminidase NNP cord-317619-o7qfugjw 266 27 inhibitor inhibitor NN cord-317619-o7qfugjw 266 28 oseltamivir oseltamivir NNP cord-317619-o7qfugjw 266 29 in in IN cord-317619-o7qfugjw 266 30 experimental experimental JJ cord-317619-o7qfugjw 266 31 human human JJ cord-317619-o7qfugjw 266 32 influenza influenza NN cord-317619-o7qfugjw 266 33 : : : cord-317619-o7qfugjw 266 34 randomized randomize VBN cord-317619-o7qfugjw 266 35 controlled control VBN cord-317619-o7qfugjw 266 36 trials trial NNS cord-317619-o7qfugjw 266 37 for for IN cord-317619-o7qfugjw 266 38 prevention prevention NN cord-317619-o7qfugjw 266 39 and and CC cord-317619-o7qfugjw 266 40 treatment treatment NN cord-317619-o7qfugjw 266 41 H1N1 H1N1 NNP cord-317619-o7qfugjw 266 42 influenza influenza NN cord-317619-o7qfugjw 266 43 and and CC cord-317619-o7qfugjw 266 44 experience experience NN cord-317619-o7qfugjw 266 45 in in IN cord-317619-o7qfugjw 266 46 three three CD cord-317619-o7qfugjw 266 47 critical critical JJ cord-317619-o7qfugjw 266 48 care care NN cord-317619-o7qfugjw 266 49 units unit NNS cord-317619-o7qfugjw 266 50 Systematic systematic JJ cord-317619-o7qfugjw 266 51 review review NN cord-317619-o7qfugjw 266 52 of of IN cord-317619-o7qfugjw 266 53 influenza influenza NN cord-317619-o7qfugjw 266 54 resistance resistance NN cord-317619-o7qfugjw 266 55 to to IN cord-317619-o7qfugjw 266 56 the the DT cord-317619-o7qfugjw 266 57 neuraminidase neuraminidase NN cord-317619-o7qfugjw 266 58 inhibitors inhibitor NNS cord-317619-o7qfugjw 266 59 Critically critically RB cord-317619-o7qfugjw 266 60 ill ill VBP cord-317619-o7qfugjw 266 61 children child NNS cord-317619-o7qfugjw 266 62 during during IN cord-317619-o7qfugjw 266 63 the the DT cord-317619-o7qfugjw 266 64 2009 2009 CD cord-317619-o7qfugjw 266 65 - - SYM cord-317619-o7qfugjw 266 66 2010 2010 CD cord-317619-o7qfugjw 266 67 influenza influenza NN cord-317619-o7qfugjw 266 68 pandemic pandemic NN cord-317619-o7qfugjw 266 69 in in IN cord-317619-o7qfugjw 266 70 the the DT cord-317619-o7qfugjw 266 71 United United NNP cord-317619-o7qfugjw 266 72 States States NNP cord-317619-o7qfugjw 266 73 Probability Probability NNP cord-317619-o7qfugjw 266 74 of of IN cord-317619-o7qfugjw 266 75 survival survival NN cord-317619-o7qfugjw 266 76 after after IN cord-317619-o7qfugjw 266 77 prolonged prolong VBN cord-317619-o7qfugjw 266 78 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 266 79 membrane membrane NN cord-317619-o7qfugjw 266 80 oxygenation oxygenation NN cord-317619-o7qfugjw 266 81 in in IN cord-317619-o7qfugjw 266 82 pediatric pediatric JJ cord-317619-o7qfugjw 266 83 patients patient NNS cord-317619-o7qfugjw 266 84 with with IN cord-317619-o7qfugjw 266 85 acute acute JJ cord-317619-o7qfugjw 266 86 respiratory respiratory JJ cord-317619-o7qfugjw 266 87 failure failure NN cord-317619-o7qfugjw 266 88 . . . cord-317619-o7qfugjw 267 1 Extracorporeal extracorporeal JJ cord-317619-o7qfugjw 267 2 life life NN cord-317619-o7qfugjw 267 3 support support NN cord-317619-o7qfugjw 267 4 organization organization NN cord-317619-o7qfugjw 267 5 Extracorporeal extracorporeal JJ cord-317619-o7qfugjw 267 6 membrane membrane NN cord-317619-o7qfugjw 267 7 oxygenation oxygenation NN cord-317619-o7qfugjw 267 8 for for IN cord-317619-o7qfugjw 267 9 ARDS ARDS NNP cord-317619-o7qfugjw 267 10 : : : cord-317619-o7qfugjw 267 11 national national JJ cord-317619-o7qfugjw 267 12 trends trend NNS cord-317619-o7qfugjw 267 13 in in IN cord-317619-o7qfugjw 267 14 the the DT cord-317619-o7qfugjw 267 15 United United NNP cord-317619-o7qfugjw 267 16 States States NNP cord-317619-o7qfugjw 267 17 Extracorporeal Extracorporeal NNP cord-317619-o7qfugjw 267 18 support support NN cord-317619-o7qfugjw 267 19 in in IN cord-317619-o7qfugjw 267 20 children child NNS cord-317619-o7qfugjw 267 21 with with IN cord-317619-o7qfugjw 267 22 pediatric pediatric JJ cord-317619-o7qfugjw 267 23 acute acute JJ cord-317619-o7qfugjw 267 24 respiratory respiratory JJ cord-317619-o7qfugjw 267 25 distress distress NN cord-317619-o7qfugjw 267 26 syndrome syndrome NN cord-317619-o7qfugjw 267 27 : : : cord-317619-o7qfugjw 267 28 proceedings proceeding NNS cord-317619-o7qfugjw 267 29 from from IN cord-317619-o7qfugjw 267 30 the the DT cord-317619-o7qfugjw 267 31 pediatric pediatric JJ cord-317619-o7qfugjw 267 32 acute acute JJ cord-317619-o7qfugjw 267 33 lung lung NN cord-317619-o7qfugjw 267 34 injury injury NN cord-317619-o7qfugjw 267 35 consensus consensus NN cord-317619-o7qfugjw 267 36 conference conference NN cord-317619-o7qfugjw 267 37 Role role NN cord-317619-o7qfugjw 267 38 of of IN cord-317619-o7qfugjw 267 39 ECMO ECMO NNP cord-317619-o7qfugjw 267 40 in in IN cord-317619-o7qfugjw 267 41 the the DT cord-317619-o7qfugjw 267 42 treatment treatment NN cord-317619-o7qfugjw 267 43 of of IN cord-317619-o7qfugjw 267 44 respiratory respiratory JJ cord-317619-o7qfugjw 267 45 syncytial syncytial JJ cord-317619-o7qfugjw 267 46 virus virus NN cord-317619-o7qfugjw 267 47 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 267 48 : : : cord-317619-o7qfugjw 267 49 a a DT cord-317619-o7qfugjw 267 50 collaborative collaborative JJ cord-317619-o7qfugjw 267 51 report report NN cord-317619-o7qfugjw 267 52 Use Use NNP cord-317619-o7qfugjw 267 53 of of IN cord-317619-o7qfugjw 267 54 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 267 55 membrane membrane NN cord-317619-o7qfugjw 267 56 oxygenation oxygenation NN cord-317619-o7qfugjw 267 57 in in IN cord-317619-o7qfugjw 267 58 the the DT cord-317619-o7qfugjw 267 59 treatment treatment NN cord-317619-o7qfugjw 267 60 of of IN cord-317619-o7qfugjw 267 61 respiratory respiratory JJ cord-317619-o7qfugjw 267 62 syncytial syncytial JJ cord-317619-o7qfugjw 267 63 virus virus NN cord-317619-o7qfugjw 267 64 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 267 65 : : : cord-317619-o7qfugjw 267 66 the the DT cord-317619-o7qfugjw 267 67 national national JJ cord-317619-o7qfugjw 267 68 experience experience NN cord-317619-o7qfugjw 267 69 , , , cord-317619-o7qfugjw 267 70 1983 1983 CD cord-317619-o7qfugjw 267 71 to to IN cord-317619-o7qfugjw 267 72 1988 1988 CD cord-317619-o7qfugjw 267 73 Severe severe JJ cord-317619-o7qfugjw 267 74 respiratory respiratory JJ cord-317619-o7qfugjw 267 75 syncytial syncytial JJ cord-317619-o7qfugjw 267 76 virus virus NN cord-317619-o7qfugjw 267 77 bronchiolitis bronchiolitis NN cord-317619-o7qfugjw 267 78 in in IN cord-317619-o7qfugjw 267 79 children child NNS cord-317619-o7qfugjw 267 80 : : : cord-317619-o7qfugjw 268 1 from from IN cord-317619-o7qfugjw 268 2 short short JJ cord-317619-o7qfugjw 268 3 mechanical mechanical JJ cord-317619-o7qfugjw 268 4 ventilation ventilation NN cord-317619-o7qfugjw 268 5 to to IN cord-317619-o7qfugjw 268 6 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 268 7 membrane membrane NN cord-317619-o7qfugjw 268 8 oxygenation oxygenation NN cord-317619-o7qfugjw 268 9 Continued continue VBD cord-317619-o7qfugjw 268 10 high high JJ cord-317619-o7qfugjw 268 11 incidence incidence NN cord-317619-o7qfugjw 268 12 of of IN cord-317619-o7qfugjw 268 13 children child NNS cord-317619-o7qfugjw 268 14 with with IN cord-317619-o7qfugjw 268 15 severe severe JJ cord-317619-o7qfugjw 268 16 influenza influenza NN cord-317619-o7qfugjw 268 17 A(H1N1)pdm09 A(H1N1)pdm09 NNP cord-317619-o7qfugjw 268 18 admitted admit VBD cord-317619-o7qfugjw 268 19 to to IN cord-317619-o7qfugjw 268 20 paediatric paediatric JJ cord-317619-o7qfugjw 268 21 intensive intensive JJ cord-317619-o7qfugjw 268 22 care care NN cord-317619-o7qfugjw 268 23 units unit NNS cord-317619-o7qfugjw 268 24 in in IN cord-317619-o7qfugjw 268 25 Germany Germany NNP cord-317619-o7qfugjw 268 26 during during IN cord-317619-o7qfugjw 268 27 the the DT cord-317619-o7qfugjw 268 28 first first JJ cord-317619-o7qfugjw 268 29 three three CD cord-317619-o7qfugjw 268 30 post post JJ cord-317619-o7qfugjw 268 31 - - JJ cord-317619-o7qfugjw 268 32 pandemic pandemic JJ cord-317619-o7qfugjw 268 33 influenza influenza NN cord-317619-o7qfugjw 268 34 seasons season NNS cord-317619-o7qfugjw 268 35 Mechanically mechanically RB cord-317619-o7qfugjw 268 36 ventilated ventilate VBD cord-317619-o7qfugjw 268 37 children child NNS cord-317619-o7qfugjw 268 38 with with IN cord-317619-o7qfugjw 268 39 2009 2009 CD cord-317619-o7qfugjw 268 40 pandemic pandemic NN cord-317619-o7qfugjw 268 41 influenza influenza NN cord-317619-o7qfugjw 268 42 A A NNP cord-317619-o7qfugjw 268 43 / / SYM cord-317619-o7qfugjw 268 44 H1N1 H1N1 NNP cord-317619-o7qfugjw 268 45 : : : cord-317619-o7qfugjw 268 46 results result NNS cord-317619-o7qfugjw 268 47 from from IN cord-317619-o7qfugjw 268 48 the the DT cord-317619-o7qfugjw 268 49 National National NNP cord-317619-o7qfugjw 268 50 Pediatric Pediatric NNP cord-317619-o7qfugjw 268 51 Intensive Intensive NNP cord-317619-o7qfugjw 268 52 Care Care NNP cord-317619-o7qfugjw 268 53 Registry Registry NNP cord-317619-o7qfugjw 268 54 in in IN cord-317619-o7qfugjw 268 55 Japan Japan NNP cord-317619-o7qfugjw 268 56 Extracorporeal extracorporeal JJ cord-317619-o7qfugjw 268 57 membrane membrane NN cord-317619-o7qfugjw 268 58 oxygenation oxygenation NN cord-317619-o7qfugjw 268 59 for for IN cord-317619-o7qfugjw 268 60 2009 2009 CD cord-317619-o7qfugjw 268 61 influenza influenza NN cord-317619-o7qfugjw 268 62 A(H1N1 A(H1N1 NNP cord-317619-o7qfugjw 268 63 ) ) -RRB- cord-317619-o7qfugjw 269 1 acute acute JJ cord-317619-o7qfugjw 269 2 respiratory respiratory JJ cord-317619-o7qfugjw 269 3 distress distress NN cord-317619-o7qfugjw 269 4 syndrome syndrome NN cord-317619-o7qfugjw 270 1 Referral referral NN cord-317619-o7qfugjw 270 2 to to IN cord-317619-o7qfugjw 270 3 an an DT cord-317619-o7qfugjw 270 4 extracorporeal extracorporeal JJ cord-317619-o7qfugjw 270 5 membrane membrane NN cord-317619-o7qfugjw 270 6 oxygenation oxygenation NN cord-317619-o7qfugjw 270 7 center center NN cord-317619-o7qfugjw 270 8 and and CC cord-317619-o7qfugjw 270 9 mortality mortality NN cord-317619-o7qfugjw 270 10 among among IN cord-317619-o7qfugjw 270 11 patients patient NNS cord-317619-o7qfugjw 270 12 with with IN cord-317619-o7qfugjw 270 13 severe severe JJ cord-317619-o7qfugjw 270 14 2009 2009 CD cord-317619-o7qfugjw 270 15 influenza influenza NN cord-317619-o7qfugjw 270 16 A(H1N1 a(h1n1 NN cord-317619-o7qfugjw 270 17 ) ) -RRB- cord-317619-o7qfugjw 271 1 The the DT cord-317619-o7qfugjw 271 2 authors author NNS cord-317619-o7qfugjw 271 3 declare declare VBP cord-317619-o7qfugjw 271 4 that that IN cord-317619-o7qfugjw 271 5 the the DT cord-317619-o7qfugjw 271 6 research research NN cord-317619-o7qfugjw 271 7 was be VBD cord-317619-o7qfugjw 271 8 conducted conduct VBN cord-317619-o7qfugjw 271 9 in in IN cord-317619-o7qfugjw 271 10 the the DT cord-317619-o7qfugjw 271 11 absence absence NN cord-317619-o7qfugjw 271 12 of of IN cord-317619-o7qfugjw 271 13 any any DT cord-317619-o7qfugjw 271 14 commercial commercial JJ cord-317619-o7qfugjw 271 15 or or CC cord-317619-o7qfugjw 271 16 financial financial JJ cord-317619-o7qfugjw 271 17 relationships relationship NNS cord-317619-o7qfugjw 271 18 that that WDT cord-317619-o7qfugjw 271 19 could could MD cord-317619-o7qfugjw 271 20 be be VB cord-317619-o7qfugjw 271 21 construed construe VBN cord-317619-o7qfugjw 271 22 as as IN cord-317619-o7qfugjw 271 23 a a DT cord-317619-o7qfugjw 271 24 potential potential JJ cord-317619-o7qfugjw 271 25 conflict conflict NN cord-317619-o7qfugjw 271 26 of of IN cord-317619-o7qfugjw 271 27 interest interest NN cord-317619-o7qfugjw 271 28 . . . cord-317619-o7qfugjw 272 1 is be VBZ cord-317619-o7qfugjw 272 2 cited cite VBN cord-317619-o7qfugjw 272 3 , , , cord-317619-o7qfugjw 272 4 in in IN cord-317619-o7qfugjw 272 5 accordance accordance NN cord-317619-o7qfugjw 272 6 with with IN cord-317619-o7qfugjw 272 7 accepted accepted JJ cord-317619-o7qfugjw 272 8 academic academic JJ cord-317619-o7qfugjw 272 9 practice practice NN cord-317619-o7qfugjw 272 10 . . . cord-317619-o7qfugjw 273 1 No no DT cord-317619-o7qfugjw 273 2 use use NN cord-317619-o7qfugjw 273 3 , , , cord-317619-o7qfugjw 273 4 distribution distribution NN cord-317619-o7qfugjw 273 5 or or CC cord-317619-o7qfugjw 273 6 reproduction reproduction NN cord-317619-o7qfugjw 273 7 is be VBZ cord-317619-o7qfugjw 273 8 permitted permit VBN cord-317619-o7qfugjw 273 9 which which WDT cord-317619-o7qfugjw 273 10 does do VBZ cord-317619-o7qfugjw 273 11 not not RB cord-317619-o7qfugjw 273 12 comply comply VB cord-317619-o7qfugjw 273 13 with with IN cord-317619-o7qfugjw 273 14 these these DT cord-317619-o7qfugjw 273 15 terms term NNS cord-317619-o7qfugjw 273 16 . . .