id sid tid token lemma pos cord-328396-p2gvpe8i 1 1 key key NN cord-328396-p2gvpe8i 1 2 : : : cord-328396-p2gvpe8i 2 1 cord-328396-p2gvpe8i cord-328396-p2gvpe8i VBN cord-328396-p2gvpe8i 2 2 authors author NNS cord-328396-p2gvpe8i 2 3 : : : cord-328396-p2gvpe8i 2 4 Kaur Kaur NNP cord-328396-p2gvpe8i 2 5 , , , cord-328396-p2gvpe8i 2 6 Savneet Savneet NNP cord-328396-p2gvpe8i 2 7 ; ; : cord-328396-p2gvpe8i 2 8 Tripathi Tripathi NNP cord-328396-p2gvpe8i 2 9 , , , cord-328396-p2gvpe8i 2 10 Dinesh Dinesh NNP cord-328396-p2gvpe8i 2 11 M. M. NNP cord-328396-p2gvpe8i 2 12 ; ; : cord-328396-p2gvpe8i 2 13 Yadav Yadav NNP cord-328396-p2gvpe8i 2 14 , , , cord-328396-p2gvpe8i 2 15 Angeera Angeera NNP cord-328396-p2gvpe8i 2 16 title title NN cord-328396-p2gvpe8i 2 17 : : : cord-328396-p2gvpe8i 2 18 The the DT cord-328396-p2gvpe8i 2 19 Enigma Enigma NNP cord-328396-p2gvpe8i 2 20 of of IN cord-328396-p2gvpe8i 2 21 Endothelium Endothelium NNP cord-328396-p2gvpe8i 2 22 in in IN cord-328396-p2gvpe8i 2 23 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 2 24 date date NN cord-328396-p2gvpe8i 2 25 : : : cord-328396-p2gvpe8i 2 26 2020 2020 CD cord-328396-p2gvpe8i 2 27 - - HYPH cord-328396-p2gvpe8i 2 28 08 08 CD cord-328396-p2gvpe8i 2 29 - - HYPH cord-328396-p2gvpe8i 2 30 04 04 CD cord-328396-p2gvpe8i 2 31 journal journal NN cord-328396-p2gvpe8i 2 32 : : : cord-328396-p2gvpe8i 3 1 Front front JJ cord-328396-p2gvpe8i 3 2 Physiol Physiol NNP cord-328396-p2gvpe8i 3 3 DOI doi NN cord-328396-p2gvpe8i 3 4 : : : cord-328396-p2gvpe8i 4 1 10.3389 10.3389 CD cord-328396-p2gvpe8i 4 2 / / SYM cord-328396-p2gvpe8i 4 3 fphys.2020.00989 fphys.2020.00989 CD cord-328396-p2gvpe8i 4 4 sha sha NNP cord-328396-p2gvpe8i 4 5 : : : cord-328396-p2gvpe8i 4 6 27922ccdc8d95b8052c69eeecbc339cd2979b10e 27922ccdc8d95b8052c69eeecbc339cd2979b10e CD cord-328396-p2gvpe8i 4 7 doc_id doc_id CD cord-328396-p2gvpe8i 4 8 : : : cord-328396-p2gvpe8i 4 9 328396 328396 CD cord-328396-p2gvpe8i 4 10 cord_uid cord_uid NNS cord-328396-p2gvpe8i 4 11 : : : cord-328396-p2gvpe8i 4 12 p2gvpe8i p2gvpe8i JJ cord-328396-p2gvpe8i 4 13 Coronavirus Coronavirus NNP cord-328396-p2gvpe8i 4 14 disease disease NN cord-328396-p2gvpe8i 4 15 2019 2019 CD cord-328396-p2gvpe8i 4 16 ( ( -LRB- cord-328396-p2gvpe8i 4 17 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 4 18 ) ) -RRB- cord-328396-p2gvpe8i 4 19 , , , cord-328396-p2gvpe8i 4 20 caused cause VBN cord-328396-p2gvpe8i 4 21 by by IN cord-328396-p2gvpe8i 4 22 severe severe JJ cord-328396-p2gvpe8i 4 23 acute acute JJ cord-328396-p2gvpe8i 4 24 respiratory respiratory JJ cord-328396-p2gvpe8i 4 25 syndrome syndrome NN cord-328396-p2gvpe8i 4 26 – – : cord-328396-p2gvpe8i 4 27 related relate VBN cord-328396-p2gvpe8i 4 28 coronavirus-2 coronavirus-2 NNP cord-328396-p2gvpe8i 4 29 ( ( -LRB- cord-328396-p2gvpe8i 4 30 SARS SARS NNP cord-328396-p2gvpe8i 4 31 - - HYPH cord-328396-p2gvpe8i 4 32 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 4 33 ) ) -RRB- cord-328396-p2gvpe8i 4 34 has have VBZ cord-328396-p2gvpe8i 4 35 affected affect VBN cord-328396-p2gvpe8i 4 36 millions million NNS cord-328396-p2gvpe8i 4 37 of of IN cord-328396-p2gvpe8i 4 38 people people NNS cord-328396-p2gvpe8i 4 39 globally globally RB cord-328396-p2gvpe8i 4 40 . . . cord-328396-p2gvpe8i 5 1 Clinically clinically RB cord-328396-p2gvpe8i 5 2 , , , cord-328396-p2gvpe8i 5 3 it -PRON- PRP cord-328396-p2gvpe8i 5 4 presents present VBZ cord-328396-p2gvpe8i 5 5 with with IN cord-328396-p2gvpe8i 5 6 mild mild JJ cord-328396-p2gvpe8i 5 7 flu flu NN cord-328396-p2gvpe8i 5 8 - - HYPH cord-328396-p2gvpe8i 5 9 like like JJ cord-328396-p2gvpe8i 5 10 symptoms symptom NNS cord-328396-p2gvpe8i 5 11 in in IN cord-328396-p2gvpe8i 5 12 most most JJS cord-328396-p2gvpe8i 5 13 cases case NNS cord-328396-p2gvpe8i 5 14 but but CC cord-328396-p2gvpe8i 5 15 can can MD cord-328396-p2gvpe8i 5 16 cause cause VB cord-328396-p2gvpe8i 5 17 respiratory respiratory JJ cord-328396-p2gvpe8i 5 18 failure failure NN cord-328396-p2gvpe8i 5 19 in in IN cord-328396-p2gvpe8i 5 20 high high JJ cord-328396-p2gvpe8i 5 21 risk risk NN cord-328396-p2gvpe8i 5 22 population population NN cord-328396-p2gvpe8i 5 23 . . . cord-328396-p2gvpe8i 6 1 With with IN cord-328396-p2gvpe8i 6 2 the the DT cord-328396-p2gvpe8i 6 3 aim aim NN cord-328396-p2gvpe8i 6 4 of of IN cord-328396-p2gvpe8i 6 5 unearthing unearth VBG cord-328396-p2gvpe8i 6 6 newer new JJR cord-328396-p2gvpe8i 6 7 treatments treatment NNS cord-328396-p2gvpe8i 6 8 , , , cord-328396-p2gvpe8i 6 9 scientists scientist NNS cord-328396-p2gvpe8i 6 10 all all RB cord-328396-p2gvpe8i 6 11 over over IN cord-328396-p2gvpe8i 6 12 the the DT cord-328396-p2gvpe8i 6 13 globe globe NN cord-328396-p2gvpe8i 6 14 are be VBP cord-328396-p2gvpe8i 6 15 striving strive VBG cord-328396-p2gvpe8i 6 16 hard hard RB cord-328396-p2gvpe8i 6 17 to to TO cord-328396-p2gvpe8i 6 18 comprehend comprehend VB cord-328396-p2gvpe8i 6 19 the the DT cord-328396-p2gvpe8i 6 20 underlying underlie VBG cord-328396-p2gvpe8i 6 21 mechanisms mechanism NNS cord-328396-p2gvpe8i 6 22 of of IN cord-328396-p2gvpe8i 6 23 COVID-19 covid-19 NN cord-328396-p2gvpe8i 6 24 . . . cord-328396-p2gvpe8i 7 1 Several several JJ cord-328396-p2gvpe8i 7 2 studies study NNS cord-328396-p2gvpe8i 7 3 till till IN cord-328396-p2gvpe8i 7 4 date date NN cord-328396-p2gvpe8i 7 5 have have VBP cord-328396-p2gvpe8i 7 6 indicated indicate VBN cord-328396-p2gvpe8i 7 7 a a DT cord-328396-p2gvpe8i 7 8 dysregulated dysregulated JJ cord-328396-p2gvpe8i 7 9 host host NN cord-328396-p2gvpe8i 7 10 immune immune JJ cord-328396-p2gvpe8i 7 11 response response NN cord-328396-p2gvpe8i 7 12 as as IN cord-328396-p2gvpe8i 7 13 the the DT cord-328396-p2gvpe8i 7 14 major major JJ cord-328396-p2gvpe8i 7 15 cause cause NN cord-328396-p2gvpe8i 7 16 of of IN cord-328396-p2gvpe8i 7 17 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 7 18 induced induce VBN cord-328396-p2gvpe8i 7 19 mortality mortality NN cord-328396-p2gvpe8i 7 20 . . . cord-328396-p2gvpe8i 8 1 In in IN cord-328396-p2gvpe8i 8 2 this this DT cord-328396-p2gvpe8i 8 3 Perspective Perspective NNP cord-328396-p2gvpe8i 8 4 , , , cord-328396-p2gvpe8i 8 5 we -PRON- PRP cord-328396-p2gvpe8i 8 6 propose propose VBP cord-328396-p2gvpe8i 8 7 a a DT cord-328396-p2gvpe8i 8 8 key key JJ cord-328396-p2gvpe8i 8 9 role role NN cord-328396-p2gvpe8i 8 10 of of IN cord-328396-p2gvpe8i 8 11 endothelium endothelium NN cord-328396-p2gvpe8i 8 12 , , , cord-328396-p2gvpe8i 8 13 particularly particularly RB cord-328396-p2gvpe8i 8 14 pulmonary pulmonary JJ cord-328396-p2gvpe8i 8 15 endothelium endothelium NN cord-328396-p2gvpe8i 8 16 in in IN cord-328396-p2gvpe8i 8 17 the the DT cord-328396-p2gvpe8i 8 18 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 8 19 of of IN cord-328396-p2gvpe8i 8 20 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 8 21 . . . cord-328396-p2gvpe8i 9 1 We -PRON- PRP cord-328396-p2gvpe8i 9 2 draw draw VBP cord-328396-p2gvpe8i 9 3 parallels parallel NNS cord-328396-p2gvpe8i 9 4 and and CC cord-328396-p2gvpe8i 9 5 divergences divergence NNS cord-328396-p2gvpe8i 9 6 between between IN cord-328396-p2gvpe8i 9 7 COVID-19-induced covid-19-induced JJ cord-328396-p2gvpe8i 9 8 respiratory respiratory JJ cord-328396-p2gvpe8i 9 9 distress distress NN cord-328396-p2gvpe8i 9 10 and and CC cord-328396-p2gvpe8i 9 11 bacterial bacterial JJ cord-328396-p2gvpe8i 9 12 sepsis sepsis NN cord-328396-p2gvpe8i 9 13 - - HYPH cord-328396-p2gvpe8i 9 14 induced induce VBN cord-328396-p2gvpe8i 9 15 lung lung NN cord-328396-p2gvpe8i 9 16 injury injury NN cord-328396-p2gvpe8i 9 17 and and CC cord-328396-p2gvpe8i 9 18 recommend recommend VB cord-328396-p2gvpe8i 9 19 the the DT cord-328396-p2gvpe8i 9 20 road road NN cord-328396-p2gvpe8i 9 21 ahead ahead RB cord-328396-p2gvpe8i 9 22 with with IN cord-328396-p2gvpe8i 9 23 respect respect NN cord-328396-p2gvpe8i 9 24 to to IN cord-328396-p2gvpe8i 9 25 identification identification NN cord-328396-p2gvpe8i 9 26 of of IN cord-328396-p2gvpe8i 9 27 endothelium endothelium NN cord-328396-p2gvpe8i 9 28 - - HYPH cord-328396-p2gvpe8i 9 29 based base VBN cord-328396-p2gvpe8i 9 30 biomarkers biomarker NNS cord-328396-p2gvpe8i 9 31 and and CC cord-328396-p2gvpe8i 9 32 plausible plausible JJ cord-328396-p2gvpe8i 9 33 treatments treatment NNS cord-328396-p2gvpe8i 9 34 for for IN cord-328396-p2gvpe8i 9 35 COVID-19 covid-19 NN cord-328396-p2gvpe8i 9 36 . . . cord-328396-p2gvpe8i 10 1 Endothelium endothelium NN cord-328396-p2gvpe8i 10 2 is be VBZ cord-328396-p2gvpe8i 10 3 a a DT cord-328396-p2gvpe8i 10 4 highly highly RB cord-328396-p2gvpe8i 10 5 specialized specialized JJ cord-328396-p2gvpe8i 10 6 and and CC cord-328396-p2gvpe8i 10 7 dynamic dynamic JJ cord-328396-p2gvpe8i 10 8 organ organ NN cord-328396-p2gvpe8i 10 9 which which WDT cord-328396-p2gvpe8i 10 10 serves serve VBZ cord-328396-p2gvpe8i 10 11 numerous numerous JJ cord-328396-p2gvpe8i 10 12 roles role NNS cord-328396-p2gvpe8i 10 13 in in IN cord-328396-p2gvpe8i 10 14 both both DT cord-328396-p2gvpe8i 10 15 physiology physiology NN cord-328396-p2gvpe8i 10 16 and and CC cord-328396-p2gvpe8i 10 17 pathophysiology pathophysiology NN cord-328396-p2gvpe8i 10 18 ( ( -LRB- cord-328396-p2gvpe8i 10 19 Galley Galley NNP cord-328396-p2gvpe8i 10 20 and and CC cord-328396-p2gvpe8i 10 21 Webster Webster NNP cord-328396-p2gvpe8i 10 22 , , , cord-328396-p2gvpe8i 10 23 2004 2004 CD cord-328396-p2gvpe8i 10 24 ) ) -RRB- cord-328396-p2gvpe8i 10 25 . . . cord-328396-p2gvpe8i 11 1 Being be VBG cord-328396-p2gvpe8i 11 2 the the DT cord-328396-p2gvpe8i 11 3 first first JJ cord-328396-p2gvpe8i 11 4 organ organ NN cord-328396-p2gvpe8i 11 5 to to TO cord-328396-p2gvpe8i 11 6 perceive perceive VB cord-328396-p2gvpe8i 11 7 any any DT cord-328396-p2gvpe8i 11 8 damage damage NN cord-328396-p2gvpe8i 11 9 to to IN cord-328396-p2gvpe8i 11 10 the the DT cord-328396-p2gvpe8i 11 11 underlying underlying JJ cord-328396-p2gvpe8i 11 12 tissue tissue NN cord-328396-p2gvpe8i 11 13 , , , cord-328396-p2gvpe8i 11 14 it -PRON- PRP cord-328396-p2gvpe8i 11 15 effectively effectively RB cord-328396-p2gvpe8i 11 16 adapts adapt VBZ cord-328396-p2gvpe8i 11 17 and and CC cord-328396-p2gvpe8i 11 18 mounts mount VBZ cord-328396-p2gvpe8i 11 19 compensatory compensatory JJ cord-328396-p2gvpe8i 11 20 responses response NNS cord-328396-p2gvpe8i 11 21 to to IN cord-328396-p2gvpe8i 11 22 any any DT cord-328396-p2gvpe8i 11 23 chemical chemical NN cord-328396-p2gvpe8i 11 24 , , , cord-328396-p2gvpe8i 11 25 mechanical mechanical JJ cord-328396-p2gvpe8i 11 26 and and CC cord-328396-p2gvpe8i 11 27 cellular cellular JJ cord-328396-p2gvpe8i 11 28 injury injury NN cord-328396-p2gvpe8i 11 29 . . . cord-328396-p2gvpe8i 12 1 The the DT cord-328396-p2gvpe8i 12 2 pulmonary pulmonary JJ cord-328396-p2gvpe8i 12 3 endothelium endothelium NN cord-328396-p2gvpe8i 12 4 that that WDT cord-328396-p2gvpe8i 12 5 shields shield VBZ cord-328396-p2gvpe8i 12 6 the the DT cord-328396-p2gvpe8i 12 7 lungs lung NNS cord-328396-p2gvpe8i 12 8 comprises comprise VBZ cord-328396-p2gvpe8i 12 9 of of IN cord-328396-p2gvpe8i 12 10 both both DT cord-328396-p2gvpe8i 12 11 macro macro JJ cord-328396-p2gvpe8i 12 12 or or CC cord-328396-p2gvpe8i 12 13 microvascular microvascular JJ cord-328396-p2gvpe8i 12 14 endothelial endothelial JJ cord-328396-p2gvpe8i 12 15 cells cell NNS cord-328396-p2gvpe8i 12 16 with with IN cord-328396-p2gvpe8i 12 17 considerable considerable JJ cord-328396-p2gvpe8i 12 18 phenotypic phenotypic NN cord-328396-p2gvpe8i 12 19 and and CC cord-328396-p2gvpe8i 12 20 functional functional JJ cord-328396-p2gvpe8i 12 21 heterogeneity heterogeneity NN cord-328396-p2gvpe8i 12 22 ( ( -LRB- cord-328396-p2gvpe8i 12 23 Aird Aird NNP cord-328396-p2gvpe8i 12 24 , , , cord-328396-p2gvpe8i 12 25 2007 2007 CD cord-328396-p2gvpe8i 12 26 ) ) -RRB- cord-328396-p2gvpe8i 12 27 . . . cord-328396-p2gvpe8i 13 1 Pulmonary pulmonary JJ cord-328396-p2gvpe8i 13 2 microvascular microvascular JJ cord-328396-p2gvpe8i 13 3 endothelial endothelial JJ cord-328396-p2gvpe8i 13 4 cells cell NNS cord-328396-p2gvpe8i 13 5 ( ( -LRB- cord-328396-p2gvpe8i 13 6 mEC mec NN cord-328396-p2gvpe8i 13 7 ) ) -RRB- cord-328396-p2gvpe8i 13 8 are be VBP cord-328396-p2gvpe8i 13 9 an an DT cord-328396-p2gvpe8i 13 10 integral integral JJ cord-328396-p2gvpe8i 13 11 part part NN cord-328396-p2gvpe8i 13 12 of of IN cord-328396-p2gvpe8i 13 13 the the DT cord-328396-p2gvpe8i 13 14 alveolar alveolar NN cord-328396-p2gvpe8i 13 15 ( ( -LRB- cord-328396-p2gvpe8i 13 16 epithelial)-capillary epithelial)-capillary JJ cord-328396-p2gvpe8i 13 17 ( ( -LRB- cord-328396-p2gvpe8i 13 18 endothelial endothelial JJ cord-328396-p2gvpe8i 13 19 ) ) -RRB- cord-328396-p2gvpe8i 13 20 barrier barrier NN cord-328396-p2gvpe8i 13 21 formed form VBN cord-328396-p2gvpe8i 13 22 by by IN cord-328396-p2gvpe8i 13 23 tight tight JJ cord-328396-p2gvpe8i 13 24 junctions junction NNS cord-328396-p2gvpe8i 13 25 and and CC cord-328396-p2gvpe8i 13 26 adherens adheren NNS cord-328396-p2gvpe8i 13 27 junctions junction NNS cord-328396-p2gvpe8i 13 28 in in IN cord-328396-p2gvpe8i 13 29 the the DT cord-328396-p2gvpe8i 13 30 lungs lung NNS cord-328396-p2gvpe8i 13 31 . . . cord-328396-p2gvpe8i 14 1 This this DT cord-328396-p2gvpe8i 14 2 impermeable impermeable JJ cord-328396-p2gvpe8i 14 3 alveolar alveolar NN cord-328396-p2gvpe8i 14 4 - - HYPH cord-328396-p2gvpe8i 14 5 capillary capillary JJ cord-328396-p2gvpe8i 14 6 barrier barrier NN cord-328396-p2gvpe8i 14 7 strictly strictly RB cord-328396-p2gvpe8i 14 8 restricts restrict VBZ cord-328396-p2gvpe8i 14 9 vascular vascular JJ cord-328396-p2gvpe8i 14 10 fluid fluid JJ cord-328396-p2gvpe8i 14 11 fluxes flux NNS cord-328396-p2gvpe8i 14 12 across across IN cord-328396-p2gvpe8i 14 13 the the DT cord-328396-p2gvpe8i 14 14 lung lung NN cord-328396-p2gvpe8i 14 15 epithelium epithelium NN cord-328396-p2gvpe8i 14 16 and and CC cord-328396-p2gvpe8i 14 17 hence hence RB cord-328396-p2gvpe8i 14 18 the the DT cord-328396-p2gvpe8i 14 19 integrity integrity NN cord-328396-p2gvpe8i 14 20 of of IN cord-328396-p2gvpe8i 14 21 this this DT cord-328396-p2gvpe8i 14 22 barrier barrier NN cord-328396-p2gvpe8i 14 23 is be VBZ cord-328396-p2gvpe8i 14 24 utmost utmost JJ cord-328396-p2gvpe8i 14 25 to to TO cord-328396-p2gvpe8i 14 26 prevent prevent VB cord-328396-p2gvpe8i 14 27 pulmonary pulmonary JJ cord-328396-p2gvpe8i 14 28 edema edema NN cord-328396-p2gvpe8i 14 29 , , , cord-328396-p2gvpe8i 14 30 congestion congestion NN cord-328396-p2gvpe8i 14 31 and and CC cord-328396-p2gvpe8i 14 32 respiratory respiratory JJ cord-328396-p2gvpe8i 14 33 failure failure NN cord-328396-p2gvpe8i 14 34 ( ( -LRB- cord-328396-p2gvpe8i 14 35 Millar Millar NNP cord-328396-p2gvpe8i 14 36 et et NNP cord-328396-p2gvpe8i 14 37 al al NNP cord-328396-p2gvpe8i 14 38 . . NNP cord-328396-p2gvpe8i 14 39 , , , cord-328396-p2gvpe8i 14 40 2016 2016 CD cord-328396-p2gvpe8i 14 41 ) ) -RRB- cord-328396-p2gvpe8i 14 42 . . . cord-328396-p2gvpe8i 15 1 In in IN cord-328396-p2gvpe8i 15 2 the the DT cord-328396-p2gvpe8i 15 3 current current JJ cord-328396-p2gvpe8i 15 4 perspective perspective NN cord-328396-p2gvpe8i 15 5 , , , cord-328396-p2gvpe8i 15 6 we -PRON- PRP cord-328396-p2gvpe8i 15 7 envisage envisage VBP cord-328396-p2gvpe8i 15 8 a a DT cord-328396-p2gvpe8i 15 9 key key JJ cord-328396-p2gvpe8i 15 10 role role NN cord-328396-p2gvpe8i 15 11 of of IN cord-328396-p2gvpe8i 15 12 mEC mec NN cord-328396-p2gvpe8i 15 13 in in IN cord-328396-p2gvpe8i 15 14 the the DT cord-328396-p2gvpe8i 15 15 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 15 16 of of IN cord-328396-p2gvpe8i 15 17 coronavirus coronavirus NN cord-328396-p2gvpe8i 15 18 disease disease NN cord-328396-p2gvpe8i 15 19 2019 2019 CD cord-328396-p2gvpe8i 15 20 caused cause VBN cord-328396-p2gvpe8i 15 21 by by IN cord-328396-p2gvpe8i 15 22 the the DT cord-328396-p2gvpe8i 15 23 novel novel JJ cord-328396-p2gvpe8i 15 24 coronavirus coronavirus NN cord-328396-p2gvpe8i 15 25 , , , cord-328396-p2gvpe8i 15 26 severe severe JJ cord-328396-p2gvpe8i 15 27 acute acute JJ cord-328396-p2gvpe8i 15 28 respiratory respiratory JJ cord-328396-p2gvpe8i 15 29 syndrome syndrome NN cord-328396-p2gvpe8i 15 30 - - HYPH cord-328396-p2gvpe8i 15 31 related relate VBN cord-328396-p2gvpe8i 15 32 coronavirus-2 coronavirus-2 NNP cord-328396-p2gvpe8i 15 33 ( ( -LRB- cord-328396-p2gvpe8i 15 34 SARS SARS NNP cord-328396-p2gvpe8i 15 35 - - HYPH cord-328396-p2gvpe8i 15 36 CoV2 CoV2 NNP cord-328396-p2gvpe8i 15 37 ) ) -RRB- cord-328396-p2gvpe8i 15 38 . . . cord-328396-p2gvpe8i 16 1 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 16 2 has have VBZ cord-328396-p2gvpe8i 16 3 a a DT cord-328396-p2gvpe8i 16 4 wide wide JJ cord-328396-p2gvpe8i 16 5 clinical clinical JJ cord-328396-p2gvpe8i 16 6 spectrum spectrum NN cord-328396-p2gvpe8i 16 7 ranging range VBG cord-328396-p2gvpe8i 16 8 from from IN cord-328396-p2gvpe8i 16 9 asymptomatic asymptomatic JJ cord-328396-p2gvpe8i 16 10 to to IN cord-328396-p2gvpe8i 16 11 mildly mildly RB cord-328396-p2gvpe8i 16 12 symptomatic symptomatic JJ cord-328396-p2gvpe8i 16 13 forms form NNS cord-328396-p2gvpe8i 16 14 to to IN cord-328396-p2gvpe8i 16 15 severe severe JJ cord-328396-p2gvpe8i 16 16 clinical clinical JJ cord-328396-p2gvpe8i 16 17 conditions condition NNS cord-328396-p2gvpe8i 16 18 such such JJ cord-328396-p2gvpe8i 16 19 as as IN cord-328396-p2gvpe8i 16 20 respiratory respiratory JJ cord-328396-p2gvpe8i 16 21 failure failure NN cord-328396-p2gvpe8i 16 22 , , , cord-328396-p2gvpe8i 16 23 sepsis sepsis NN cord-328396-p2gvpe8i 16 24 and and CC cord-328396-p2gvpe8i 16 25 multiorgan multiorgan NNP cord-328396-p2gvpe8i 16 26 dysfunction dysfunction NN cord-328396-p2gvpe8i 16 27 syndromes syndrome NNS cord-328396-p2gvpe8i 16 28 ( ( -LRB- cord-328396-p2gvpe8i 16 29 MODS MODS NNP cord-328396-p2gvpe8i 16 30 ) ) -RRB- cord-328396-p2gvpe8i 16 31 . . . cord-328396-p2gvpe8i 17 1 Most Most JJS cord-328396-p2gvpe8i 17 2 of of IN cord-328396-p2gvpe8i 17 3 the the DT cord-328396-p2gvpe8i 17 4 hospitalized hospitalize VBN cord-328396-p2gvpe8i 17 5 critically critically RB cord-328396-p2gvpe8i 17 6 ill ill VBP cord-328396-p2gvpe8i 17 7 COVID-19 covid-19 CD cord-328396-p2gvpe8i 17 8 patients patient NNS cord-328396-p2gvpe8i 17 9 have have VBP cord-328396-p2gvpe8i 17 10 pneumonia pneumonia NN cord-328396-p2gvpe8i 17 11 with with IN cord-328396-p2gvpe8i 17 12 abnormal abnormal JJ cord-328396-p2gvpe8i 17 13 chest chest NN cord-328396-p2gvpe8i 18 1 CT CT NNP cord-328396-p2gvpe8i 18 2 scans scan NNS cord-328396-p2gvpe8i 18 3 and and CC cord-328396-p2gvpe8i 18 4 acute acute JJ cord-328396-p2gvpe8i 18 5 respiratory respiratory JJ cord-328396-p2gvpe8i 18 6 distress distress NN cord-328396-p2gvpe8i 18 7 syndrome syndrome NN cord-328396-p2gvpe8i 18 8 ( ( -LRB- cord-328396-p2gvpe8i 18 9 ARDS ARDS NNP cord-328396-p2gvpe8i 18 10 ) ) -RRB- cord-328396-p2gvpe8i 18 11 seems seem VBZ cord-328396-p2gvpe8i 18 12 to to TO cord-328396-p2gvpe8i 18 13 be be VB cord-328396-p2gvpe8i 18 14 the the DT cord-328396-p2gvpe8i 18 15 major major JJ cord-328396-p2gvpe8i 18 16 causes cause NNS cord-328396-p2gvpe8i 18 17 of of IN cord-328396-p2gvpe8i 18 18 death death NN cord-328396-p2gvpe8i 18 19 in in IN cord-328396-p2gvpe8i 18 20 these these DT cord-328396-p2gvpe8i 18 21 patients patient NNS cord-328396-p2gvpe8i 18 22 ( ( -LRB- cord-328396-p2gvpe8i 18 23 Yang Yang NNP cord-328396-p2gvpe8i 18 24 F. F. NNP cord-328396-p2gvpe8i 18 25 et et FW cord-328396-p2gvpe8i 18 26 al al NNP cord-328396-p2gvpe8i 18 27 . . NNP cord-328396-p2gvpe8i 18 28 , , , cord-328396-p2gvpe8i 18 29 2020 2020 CD cord-328396-p2gvpe8i 18 30 ) ) -RRB- cord-328396-p2gvpe8i 18 31 . . . cord-328396-p2gvpe8i 19 1 ARDS ARDS NNP cord-328396-p2gvpe8i 19 2 is be VBZ cord-328396-p2gvpe8i 19 3 nothing nothing NN cord-328396-p2gvpe8i 19 4 but but IN cord-328396-p2gvpe8i 19 5 a a DT cord-328396-p2gvpe8i 19 6 reflection reflection NN cord-328396-p2gvpe8i 19 7 of of IN cord-328396-p2gvpe8i 19 8 severe severe JJ cord-328396-p2gvpe8i 19 9 mEC mec NN cord-328396-p2gvpe8i 19 10 dysfunction dysfunction NN cord-328396-p2gvpe8i 19 11 involving involve VBG cord-328396-p2gvpe8i 19 12 changes change NNS cord-328396-p2gvpe8i 19 13 in in IN cord-328396-p2gvpe8i 19 14 vascular vascular JJ cord-328396-p2gvpe8i 19 15 permeability permeability NN cord-328396-p2gvpe8i 19 16 , , , cord-328396-p2gvpe8i 19 17 inflammation inflammation NN cord-328396-p2gvpe8i 19 18 , , , cord-328396-p2gvpe8i 19 19 accumulation accumulation NN cord-328396-p2gvpe8i 19 20 and and CC cord-328396-p2gvpe8i 19 21 extravasation extravasation NN cord-328396-p2gvpe8i 19 22 of of IN cord-328396-p2gvpe8i 19 23 leucocytes leucocytes NNP cord-328396-p2gvpe8i 19 24 , , , cord-328396-p2gvpe8i 19 25 activation activation NN cord-328396-p2gvpe8i 19 26 of of IN cord-328396-p2gvpe8i 19 27 procoagulant procoagulant JJ cord-328396-p2gvpe8i 19 28 pathways pathway NNS cord-328396-p2gvpe8i 19 29 and and CC cord-328396-p2gvpe8i 19 30 disruption disruption NN cord-328396-p2gvpe8i 19 31 of of IN cord-328396-p2gvpe8i 19 32 alveolarcapillary alveolarcapillary JJ cord-328396-p2gvpe8i 19 33 barrier barrier NN cord-328396-p2gvpe8i 20 1 ( ( -LRB- cord-328396-p2gvpe8i 20 2 Matthay Matthay NNP cord-328396-p2gvpe8i 20 3 et et FW cord-328396-p2gvpe8i 20 4 al al NNP cord-328396-p2gvpe8i 20 5 . . NNP cord-328396-p2gvpe8i 20 6 , , , cord-328396-p2gvpe8i 20 7 2019 2019 CD cord-328396-p2gvpe8i 20 8 ) ) -RRB- cord-328396-p2gvpe8i 20 9 . . . cord-328396-p2gvpe8i 21 1 Evidence evidence NN cord-328396-p2gvpe8i 21 2 from from IN cord-328396-p2gvpe8i 21 3 several several JJ cord-328396-p2gvpe8i 21 4 studies study NNS cord-328396-p2gvpe8i 21 5 have have VBP cord-328396-p2gvpe8i 21 6 indicated indicate VBN cord-328396-p2gvpe8i 21 7 that that IN cord-328396-p2gvpe8i 21 8 patients patient NNS cord-328396-p2gvpe8i 21 9 with with IN cord-328396-p2gvpe8i 21 10 COVID-19 covid-19 DT cord-328396-p2gvpe8i 21 11 exhibit exhibit NN cord-328396-p2gvpe8i 21 12 most most JJS cord-328396-p2gvpe8i 21 13 of of IN cord-328396-p2gvpe8i 21 14 these these DT cord-328396-p2gvpe8i 21 15 attributes attribute NNS cord-328396-p2gvpe8i 21 16 . . . cord-328396-p2gvpe8i 22 1 Lung lung NN cord-328396-p2gvpe8i 22 2 pathology pathology NN cord-328396-p2gvpe8i 22 3 from from IN cord-328396-p2gvpe8i 22 4 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 22 5 patients patient NNS cord-328396-p2gvpe8i 22 6 has have VBZ cord-328396-p2gvpe8i 22 7 depicted depict VBN cord-328396-p2gvpe8i 22 8 that that IN cord-328396-p2gvpe8i 22 9 along along IN cord-328396-p2gvpe8i 22 10 with with IN cord-328396-p2gvpe8i 22 11 pulmonary pulmonary JJ cord-328396-p2gvpe8i 22 12 type type NN cord-328396-p2gvpe8i 22 13 2 2 CD cord-328396-p2gvpe8i 22 14 alveolar alveolar NN cord-328396-p2gvpe8i 22 15 epithelial epithelial JJ cord-328396-p2gvpe8i 22 16 cells cell NNS cord-328396-p2gvpe8i 22 17 , , , cord-328396-p2gvpe8i 22 18 endothelial endothelial JJ cord-328396-p2gvpe8i 22 19 cells cell NNS cord-328396-p2gvpe8i 22 20 in in IN cord-328396-p2gvpe8i 22 21 the the DT cord-328396-p2gvpe8i 22 22 systemic systemic JJ cord-328396-p2gvpe8i 22 23 venules venule NNS cord-328396-p2gvpe8i 22 24 are be VBP cord-328396-p2gvpe8i 22 25 also also RB cord-328396-p2gvpe8i 22 26 desquamated desquamate VBN cord-328396-p2gvpe8i 22 27 and and CC cord-328396-p2gvpe8i 22 28 an an DT cord-328396-p2gvpe8i 22 29 inflammatory inflammatory JJ cord-328396-p2gvpe8i 22 30 reaction reaction NN cord-328396-p2gvpe8i 22 31 is be VBZ cord-328396-p2gvpe8i 22 32 present present JJ cord-328396-p2gvpe8i 22 33 in in IN cord-328396-p2gvpe8i 22 34 blood blood NN cord-328396-p2gvpe8i 22 35 vessel vessel NN cord-328396-p2gvpe8i 22 36 walls wall NNS cord-328396-p2gvpe8i 22 37 ( ( -LRB- cord-328396-p2gvpe8i 22 38 vasculitis vasculitis NN cord-328396-p2gvpe8i 22 39 ) ) -RRB- cord-328396-p2gvpe8i 22 40 , , , cord-328396-p2gvpe8i 22 41 suggestive suggestive JJ cord-328396-p2gvpe8i 22 42 of of IN cord-328396-p2gvpe8i 22 43 intense intense JJ cord-328396-p2gvpe8i 22 44 vascular vascular JJ cord-328396-p2gvpe8i 22 45 reactions reaction NNS cord-328396-p2gvpe8i 22 46 ( ( -LRB- cord-328396-p2gvpe8i 22 47 Ding Ding NNP cord-328396-p2gvpe8i 22 48 et et FW cord-328396-p2gvpe8i 22 49 al al NNP cord-328396-p2gvpe8i 22 50 . . NNP cord-328396-p2gvpe8i 22 51 , , , cord-328396-p2gvpe8i 22 52 2003 2003 CD cord-328396-p2gvpe8i 22 53 ) ) -RRB- cord-328396-p2gvpe8i 22 54 . . . cord-328396-p2gvpe8i 23 1 Lung lung NN cord-328396-p2gvpe8i 23 2 autopsies autopsy NNS cord-328396-p2gvpe8i 23 3 from from IN cord-328396-p2gvpe8i 23 4 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 23 5 patients patient NNS cord-328396-p2gvpe8i 23 6 also also RB cord-328396-p2gvpe8i 23 7 show show VBP cord-328396-p2gvpe8i 23 8 massive massive JJ cord-328396-p2gvpe8i 23 9 neutrophil neutrophil NN cord-328396-p2gvpe8i 23 10 infiltration infiltration NN cord-328396-p2gvpe8i 23 11 in in IN cord-328396-p2gvpe8i 23 12 pulmonary pulmonary JJ cord-328396-p2gvpe8i 23 13 capillaries capillary NNS cord-328396-p2gvpe8i 23 14 , , , cord-328396-p2gvpe8i 23 15 acute acute JJ cord-328396-p2gvpe8i 23 16 capillaritis capillaritis NN cord-328396-p2gvpe8i 23 17 and and CC cord-328396-p2gvpe8i 23 18 extravasation extravasation NN cord-328396-p2gvpe8i 23 19 of of IN cord-328396-p2gvpe8i 23 20 neutrophils neutrophil NNS cord-328396-p2gvpe8i 23 21 into into IN cord-328396-p2gvpe8i 23 22 the the DT cord-328396-p2gvpe8i 23 23 alveolar alveolar JJ cord-328396-p2gvpe8i 23 24 space space NN cord-328396-p2gvpe8i 23 25 ( ( -LRB- cord-328396-p2gvpe8i 23 26 Fox Fox NNP cord-328396-p2gvpe8i 23 27 et et FW cord-328396-p2gvpe8i 23 28 al al NNP cord-328396-p2gvpe8i 23 29 . . NNP cord-328396-p2gvpe8i 23 30 , , , cord-328396-p2gvpe8i 23 31 2020 2020 CD cord-328396-p2gvpe8i 23 32 ; ; : cord-328396-p2gvpe8i 23 33 Liu Liu NNP cord-328396-p2gvpe8i 23 34 et et NNP cord-328396-p2gvpe8i 23 35 al al NNP cord-328396-p2gvpe8i 23 36 . . NNP cord-328396-p2gvpe8i 23 37 , , , cord-328396-p2gvpe8i 23 38 2020 2020 CD cord-328396-p2gvpe8i 23 39 ) ) -RRB- cord-328396-p2gvpe8i 23 40 . . . cord-328396-p2gvpe8i 24 1 Pulmonary pulmonary JJ cord-328396-p2gvpe8i 24 2 neutrophilia neutrophilia NN cord-328396-p2gvpe8i 24 3 is be VBZ cord-328396-p2gvpe8i 24 4 predictive predictive JJ cord-328396-p2gvpe8i 24 5 of of IN cord-328396-p2gvpe8i 24 6 poor poor JJ cord-328396-p2gvpe8i 24 7 clinical clinical JJ cord-328396-p2gvpe8i 24 8 outcomes outcome NNS cord-328396-p2gvpe8i 24 9 and and CC cord-328396-p2gvpe8i 24 10 also also RB cord-328396-p2gvpe8i 24 11 neutrophil neutrophil NN cord-328396-p2gvpe8i 24 12 - - HYPH cord-328396-p2gvpe8i 24 13 to to IN cord-328396-p2gvpe8i 24 14 - - HYPH cord-328396-p2gvpe8i 24 15 lymphocyte lymphocyte NN cord-328396-p2gvpe8i 24 16 ratio ratio NN cord-328396-p2gvpe8i 24 17 is be VBZ cord-328396-p2gvpe8i 24 18 an an DT cord-328396-p2gvpe8i 24 19 independent independent JJ cord-328396-p2gvpe8i 24 20 risk risk NN cord-328396-p2gvpe8i 24 21 factor factor NN cord-328396-p2gvpe8i 24 22 of of IN cord-328396-p2gvpe8i 24 23 disease disease NN cord-328396-p2gvpe8i 24 24 severity severity NN cord-328396-p2gvpe8i 24 25 in in IN cord-328396-p2gvpe8i 24 26 these these DT cord-328396-p2gvpe8i 24 27 patients patient NNS cord-328396-p2gvpe8i 24 28 ) ) -RRB- cord-328396-p2gvpe8i 24 29 . . . cord-328396-p2gvpe8i 25 1 An an DT cord-328396-p2gvpe8i 25 2 inflamed inflamed JJ cord-328396-p2gvpe8i 25 3 / / SYM cord-328396-p2gvpe8i 25 4 injured injure VBN cord-328396-p2gvpe8i 25 5 endothelium endothelium NN cord-328396-p2gvpe8i 25 6 due due IN cord-328396-p2gvpe8i 25 7 to to IN cord-328396-p2gvpe8i 25 8 increased increase VBN cord-328396-p2gvpe8i 25 9 expression expression NN cord-328396-p2gvpe8i 25 10 of of IN cord-328396-p2gvpe8i 25 11 adhesion adhesion NN cord-328396-p2gvpe8i 25 12 molecules molecule NNS cord-328396-p2gvpe8i 25 13 , , , cord-328396-p2gvpe8i 25 14 including include VBG cord-328396-p2gvpe8i 25 15 E e NN cord-328396-p2gvpe8i 25 16 - - : cord-328396-p2gvpe8i 25 17 and and CC cord-328396-p2gvpe8i 25 18 P p NN cord-328396-p2gvpe8i 25 19 - - HYPH cord-328396-p2gvpe8i 25 20 selectins selectin NNS cord-328396-p2gvpe8i 25 21 , , , cord-328396-p2gvpe8i 25 22 loss loss NN cord-328396-p2gvpe8i 25 23 of of IN cord-328396-p2gvpe8i 25 24 cadherin cadherin NN cord-328396-p2gvpe8i 25 25 junctions junction NNS cord-328396-p2gvpe8i 25 26 and and CC cord-328396-p2gvpe8i 25 27 hence hence RB cord-328396-p2gvpe8i 25 28 altered alter VBD cord-328396-p2gvpe8i 25 29 vascular vascular JJ cord-328396-p2gvpe8i 25 30 permeability permeability NN cord-328396-p2gvpe8i 25 31 promotes promote VBZ cord-328396-p2gvpe8i 25 32 the the DT cord-328396-p2gvpe8i 25 33 adhesion adhesion NN cord-328396-p2gvpe8i 25 34 and and CC cord-328396-p2gvpe8i 25 35 migration migration NN cord-328396-p2gvpe8i 25 36 of of IN cord-328396-p2gvpe8i 25 37 neutrophils neutrophil NNS cord-328396-p2gvpe8i 25 38 . . . cord-328396-p2gvpe8i 26 1 Neutrophilia Neutrophilia NNP cord-328396-p2gvpe8i 26 2 can can MD cord-328396-p2gvpe8i 26 3 induce induce VB cord-328396-p2gvpe8i 26 4 injury injury NN cord-328396-p2gvpe8i 26 5 to to IN cord-328396-p2gvpe8i 26 6 the the DT cord-328396-p2gvpe8i 26 7 endothelium endothelium NN cord-328396-p2gvpe8i 26 8 - - HYPH cord-328396-p2gvpe8i 26 9 epithelial epithelial JJ cord-328396-p2gvpe8i 26 10 alveolar alveolar JJ cord-328396-p2gvpe8i 26 11 barrier barrier NN cord-328396-p2gvpe8i 26 12 , , , cord-328396-p2gvpe8i 26 13 causing cause VBG cord-328396-p2gvpe8i 26 14 further further JJ cord-328396-p2gvpe8i 26 15 damage damage NN cord-328396-p2gvpe8i 26 16 to to IN cord-328396-p2gvpe8i 26 17 the the DT cord-328396-p2gvpe8i 26 18 lungs lung NNS cord-328396-p2gvpe8i 26 19 . . . cord-328396-p2gvpe8i 27 1 A a DT cord-328396-p2gvpe8i 27 2 recent recent JJ cord-328396-p2gvpe8i 27 3 report report NN cord-328396-p2gvpe8i 27 4 has have VBZ cord-328396-p2gvpe8i 27 5 illustrated illustrate VBN cord-328396-p2gvpe8i 27 6 that that DT cord-328396-p2gvpe8i 27 7 neutrophil neutrophil NN cord-328396-p2gvpe8i 27 8 extracellular extracellular JJ cord-328396-p2gvpe8i 27 9 traps trap NNS cord-328396-p2gvpe8i 27 10 ( ( -LRB- cord-328396-p2gvpe8i 27 11 NETs net NNS cord-328396-p2gvpe8i 27 12 ) ) -RRB- cord-328396-p2gvpe8i 27 13 are be VBP cord-328396-p2gvpe8i 27 14 enhanced enhance VBN cord-328396-p2gvpe8i 27 15 in in IN cord-328396-p2gvpe8i 27 16 hospitalized hospitalize VBN cord-328396-p2gvpe8i 27 17 COVID-19 covid-19 CD cord-328396-p2gvpe8i 27 18 patients patient NNS cord-328396-p2gvpe8i 27 19 receiving receive VBG cord-328396-p2gvpe8i 27 20 mechanical mechanical JJ cord-328396-p2gvpe8i 27 21 ventilation ventilation NN cord-328396-p2gvpe8i 27 22 as as IN cord-328396-p2gvpe8i 27 23 compared compare VBN cord-328396-p2gvpe8i 27 24 with with IN cord-328396-p2gvpe8i 27 25 hospitalized hospitalize VBN cord-328396-p2gvpe8i 27 26 patients patient NNS cord-328396-p2gvpe8i 27 27 breathing breathe VBG cord-328396-p2gvpe8i 27 28 room room NN cord-328396-p2gvpe8i 27 29 air air NN cord-328396-p2gvpe8i 27 30 . . . cord-328396-p2gvpe8i 28 1 The the DT cord-328396-p2gvpe8i 28 2 study study NN cord-328396-p2gvpe8i 28 3 has have VBZ cord-328396-p2gvpe8i 28 4 also also RB cord-328396-p2gvpe8i 28 5 documented document VBN cord-328396-p2gvpe8i 28 6 that that IN cord-328396-p2gvpe8i 28 7 sera sera NNP cord-328396-p2gvpe8i 28 8 from from IN cord-328396-p2gvpe8i 28 9 individuals individual NNS cord-328396-p2gvpe8i 28 10 with with IN cord-328396-p2gvpe8i 28 11 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 28 12 trigger trigger NN cord-328396-p2gvpe8i 28 13 NET net NN cord-328396-p2gvpe8i 28 14 release release NN cord-328396-p2gvpe8i 28 15 from from IN cord-328396-p2gvpe8i 28 16 control control NN cord-328396-p2gvpe8i 28 17 neutrophils neutrophil NNS cord-328396-p2gvpe8i 28 18 in in IN cord-328396-p2gvpe8i 28 19 vitro vitro FW cord-328396-p2gvpe8i 28 20 ( ( -LRB- cord-328396-p2gvpe8i 28 21 Zuo Zuo NNP cord-328396-p2gvpe8i 28 22 et et FW cord-328396-p2gvpe8i 28 23 al al NNP cord-328396-p2gvpe8i 28 24 . . NNP cord-328396-p2gvpe8i 28 25 , , , cord-328396-p2gvpe8i 28 26 2020 2020 CD cord-328396-p2gvpe8i 28 27 ) ) -RRB- cord-328396-p2gvpe8i 28 28 . . . cord-328396-p2gvpe8i 29 1 NETs net NNS cord-328396-p2gvpe8i 29 2 are be VBP cord-328396-p2gvpe8i 29 3 extracellular extracellular JJ cord-328396-p2gvpe8i 29 4 DNA dna NN cord-328396-p2gvpe8i 29 5 fibers fiber NNS cord-328396-p2gvpe8i 29 6 of of IN cord-328396-p2gvpe8i 29 7 neutrophils neutrophil NNS cord-328396-p2gvpe8i 29 8 carrying carry VBG cord-328396-p2gvpe8i 29 9 nuclear nuclear JJ cord-328396-p2gvpe8i 29 10 proteins protein NNS cord-328396-p2gvpe8i 29 11 , , , cord-328396-p2gvpe8i 29 12 such such JJ cord-328396-p2gvpe8i 29 13 as as IN cord-328396-p2gvpe8i 29 14 histones histone NNS cord-328396-p2gvpe8i 29 15 and and CC cord-328396-p2gvpe8i 29 16 bactericidal bactericidal JJ cord-328396-p2gvpe8i 29 17 proteins protein NNS cord-328396-p2gvpe8i 29 18 . . . cord-328396-p2gvpe8i 30 1 NET net NN cord-328396-p2gvpe8i 30 2 formation formation NN cord-328396-p2gvpe8i 30 3 in in IN cord-328396-p2gvpe8i 30 4 the the DT cord-328396-p2gvpe8i 30 5 lungs lung NNS cord-328396-p2gvpe8i 30 6 is be VBZ cord-328396-p2gvpe8i 30 7 documented document VBN cord-328396-p2gvpe8i 30 8 in in IN cord-328396-p2gvpe8i 30 9 bacterial bacterial JJ cord-328396-p2gvpe8i 30 10 sepsis sepsis NN cord-328396-p2gvpe8i 30 11 and and CC cord-328396-p2gvpe8i 30 12 thrombosis thrombosis NN cord-328396-p2gvpe8i 30 13 , , , cord-328396-p2gvpe8i 30 14 however however RB cord-328396-p2gvpe8i 30 15 , , , cord-328396-p2gvpe8i 30 16 their -PRON- PRP$ cord-328396-p2gvpe8i 30 17 role role NN cord-328396-p2gvpe8i 30 18 in in IN cord-328396-p2gvpe8i 30 19 viral viral JJ cord-328396-p2gvpe8i 30 20 infections infection NNS cord-328396-p2gvpe8i 30 21 is be VBZ cord-328396-p2gvpe8i 30 22 not not RB cord-328396-p2gvpe8i 30 23 very very RB cord-328396-p2gvpe8i 30 24 well well RB cord-328396-p2gvpe8i 30 25 known known JJ cord-328396-p2gvpe8i 30 26 except except IN cord-328396-p2gvpe8i 30 27 for for IN cord-328396-p2gvpe8i 30 28 a a DT cord-328396-p2gvpe8i 30 29 report report NN cord-328396-p2gvpe8i 30 30 which which WDT cord-328396-p2gvpe8i 30 31 has have VBZ cord-328396-p2gvpe8i 30 32 shown show VBN cord-328396-p2gvpe8i 30 33 their -PRON- PRP$ cord-328396-p2gvpe8i 30 34 presence presence NN cord-328396-p2gvpe8i 30 35 in in IN cord-328396-p2gvpe8i 30 36 influenza influenza NN cord-328396-p2gvpe8i 30 37 virusinduced virusinduce VBN cord-328396-p2gvpe8i 30 38 pneumonia pneumonia NN cord-328396-p2gvpe8i 30 39 in in IN cord-328396-p2gvpe8i 30 40 vivo vivo NNP cord-328396-p2gvpe8i 31 1 ( ( -LRB- cord-328396-p2gvpe8i 31 2 Narasaraju Narasaraju NNP cord-328396-p2gvpe8i 31 3 et et NNP cord-328396-p2gvpe8i 31 4 al al NNP cord-328396-p2gvpe8i 31 5 . . NNP cord-328396-p2gvpe8i 31 6 , , , cord-328396-p2gvpe8i 31 7 2011 2011 CD cord-328396-p2gvpe8i 31 8 ) ) -RRB- cord-328396-p2gvpe8i 31 9 . . . cord-328396-p2gvpe8i 32 1 NETs net NNS cord-328396-p2gvpe8i 32 2 represent represent VBP cord-328396-p2gvpe8i 32 3 one one CD cord-328396-p2gvpe8i 32 4 of of IN cord-328396-p2gvpe8i 32 5 the the DT cord-328396-p2gvpe8i 32 6 powerful powerful JJ cord-328396-p2gvpe8i 32 7 host host NN cord-328396-p2gvpe8i 32 8 mechanisms mechanism NNS cord-328396-p2gvpe8i 32 9 to to TO cord-328396-p2gvpe8i 32 10 damage damage VB cord-328396-p2gvpe8i 32 11 the the DT cord-328396-p2gvpe8i 32 12 microbes microbe NNS cord-328396-p2gvpe8i 32 13 . . . cord-328396-p2gvpe8i 33 1 They -PRON- PRP cord-328396-p2gvpe8i 33 2 are be VBP cord-328396-p2gvpe8i 33 3 , , , cord-328396-p2gvpe8i 33 4 however however RB cord-328396-p2gvpe8i 33 5 , , , cord-328396-p2gvpe8i 33 6 suicidal suicidal JJ cord-328396-p2gvpe8i 33 7 , , , cord-328396-p2gvpe8i 33 8 if if IN cord-328396-p2gvpe8i 33 9 present present JJ cord-328396-p2gvpe8i 33 10 in in IN cord-328396-p2gvpe8i 33 11 excess excess NN cord-328396-p2gvpe8i 33 12 as as IN cord-328396-p2gvpe8i 33 13 they -PRON- PRP cord-328396-p2gvpe8i 33 14 can can MD cord-328396-p2gvpe8i 33 15 attach attach VB cord-328396-p2gvpe8i 33 16 to to IN cord-328396-p2gvpe8i 33 17 the the DT cord-328396-p2gvpe8i 33 18 capillary capillary JJ cord-328396-p2gvpe8i 33 19 endothelium endothelium NN cord-328396-p2gvpe8i 33 20 , , , cord-328396-p2gvpe8i 33 21 collate collate VB cord-328396-p2gvpe8i 33 22 with with IN cord-328396-p2gvpe8i 33 23 the the DT cord-328396-p2gvpe8i 33 24 platelets platelet NNS cord-328396-p2gvpe8i 33 25 to to TO cord-328396-p2gvpe8i 33 26 induce induce VB cord-328396-p2gvpe8i 33 27 coagulation coagulation NN cord-328396-p2gvpe8i 33 28 and and CC cord-328396-p2gvpe8i 33 29 thus thus RB cord-328396-p2gvpe8i 33 30 cause cause VB cord-328396-p2gvpe8i 33 31 damage damage NN cord-328396-p2gvpe8i 33 32 to to IN cord-328396-p2gvpe8i 33 33 the the DT cord-328396-p2gvpe8i 33 34 alveolar alveolar NN cord-328396-p2gvpe8i 33 35 - - HYPH cord-328396-p2gvpe8i 33 36 capillary capillary JJ cord-328396-p2gvpe8i 33 37 barrier barrier NN cord-328396-p2gvpe8i 33 38 , , , cord-328396-p2gvpe8i 33 39 leading lead VBG cord-328396-p2gvpe8i 33 40 to to IN cord-328396-p2gvpe8i 33 41 vascular vascular JJ cord-328396-p2gvpe8i 33 42 leakage leakage NN cord-328396-p2gvpe8i 33 43 , , , cord-328396-p2gvpe8i 33 44 edema edema NN cord-328396-p2gvpe8i 33 45 and and CC cord-328396-p2gvpe8i 33 46 finally finally RB cord-328396-p2gvpe8i 33 47 ARDS ARDS NNP cord-328396-p2gvpe8i 33 48 ( ( -LRB- cord-328396-p2gvpe8i 33 49 Sørensen Sørensen NNP cord-328396-p2gvpe8i 33 50 and and CC cord-328396-p2gvpe8i 33 51 Borregaard Borregaard NNP cord-328396-p2gvpe8i 33 52 , , , cord-328396-p2gvpe8i 33 53 2016 2016 CD cord-328396-p2gvpe8i 33 54 ) ) -RRB- cord-328396-p2gvpe8i 33 55 . . . cord-328396-p2gvpe8i 34 1 Ascertaining ascertain VBG cord-328396-p2gvpe8i 34 2 the the DT cord-328396-p2gvpe8i 34 3 role role NN cord-328396-p2gvpe8i 34 4 of of IN cord-328396-p2gvpe8i 34 5 NETs net NNS cord-328396-p2gvpe8i 34 6 as as IN cord-328396-p2gvpe8i 34 7 markers marker NNS cord-328396-p2gvpe8i 34 8 of of IN cord-328396-p2gvpe8i 34 9 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 34 10 disease disease NN cord-328396-p2gvpe8i 34 11 severity severity NN cord-328396-p2gvpe8i 34 12 needs need VBZ cord-328396-p2gvpe8i 34 13 further further JJ cord-328396-p2gvpe8i 34 14 systematic systematic JJ cord-328396-p2gvpe8i 34 15 studies study NNS cord-328396-p2gvpe8i 34 16 and and CC cord-328396-p2gvpe8i 34 17 targeting targeting NN cord-328396-p2gvpe8i 34 18 of of IN cord-328396-p2gvpe8i 34 19 NETs net NNS cord-328396-p2gvpe8i 34 20 to to TO cord-328396-p2gvpe8i 34 21 rescue rescue VB cord-328396-p2gvpe8i 34 22 the the DT cord-328396-p2gvpe8i 34 23 lung lung NN cord-328396-p2gvpe8i 34 24 endothelium endothelium NN cord-328396-p2gvpe8i 34 25 represents represent VBZ cord-328396-p2gvpe8i 34 26 a a DT cord-328396-p2gvpe8i 34 27 worthwhile worthwhile JJ cord-328396-p2gvpe8i 34 28 therapeutic therapeutic JJ cord-328396-p2gvpe8i 34 29 option option NN cord-328396-p2gvpe8i 34 30 in in IN cord-328396-p2gvpe8i 34 31 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 34 32 . . . cord-328396-p2gvpe8i 35 1 Several several JJ cord-328396-p2gvpe8i 35 2 studies study NNS cord-328396-p2gvpe8i 35 3 have have VBP cord-328396-p2gvpe8i 35 4 indicated indicate VBN cord-328396-p2gvpe8i 35 5 the the DT cord-328396-p2gvpe8i 35 6 presence presence NN cord-328396-p2gvpe8i 35 7 of of IN cord-328396-p2gvpe8i 35 8 atypical atypical JJ cord-328396-p2gvpe8i 35 9 manifestations manifestation NNS cord-328396-p2gvpe8i 35 10 of of IN cord-328396-p2gvpe8i 35 11 ARDS ARDS NNP cord-328396-p2gvpe8i 35 12 in in IN cord-328396-p2gvpe8i 35 13 some some DT cord-328396-p2gvpe8i 35 14 severe severe JJ cord-328396-p2gvpe8i 35 15 patients patient NNS cord-328396-p2gvpe8i 35 16 of of IN cord-328396-p2gvpe8i 35 17 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 35 18 . . . cord-328396-p2gvpe8i 36 1 They -PRON- PRP cord-328396-p2gvpe8i 36 2 exhibit exhibit VBP cord-328396-p2gvpe8i 36 3 near near IN cord-328396-p2gvpe8i 36 4 normal normal JJ cord-328396-p2gvpe8i 36 5 pulmonary pulmonary JJ cord-328396-p2gvpe8i 36 6 compliance compliance NN cord-328396-p2gvpe8i 36 7 of of IN cord-328396-p2gvpe8i 36 8 > > XX cord-328396-p2gvpe8i 37 1 50 50 CD cord-328396-p2gvpe8i 37 2 ml ml NNS cord-328396-p2gvpe8i 37 3 / / SYM cord-328396-p2gvpe8i 37 4 cmH cmh NN cord-328396-p2gvpe8i 37 5 2 2 CD cord-328396-p2gvpe8i 37 6 O o NN cord-328396-p2gvpe8i 37 7 with with IN cord-328396-p2gvpe8i 37 8 severe severe JJ cord-328396-p2gvpe8i 37 9 hypoxemia hypoxemia NN cord-328396-p2gvpe8i 37 10 , , , cord-328396-p2gvpe8i 37 11 which which WDT cord-328396-p2gvpe8i 37 12 seems seem VBZ cord-328396-p2gvpe8i 37 13 to to TO cord-328396-p2gvpe8i 37 14 emanate emanate VB cord-328396-p2gvpe8i 37 15 due due IN cord-328396-p2gvpe8i 37 16 to to IN cord-328396-p2gvpe8i 37 17 impaired impaired JJ cord-328396-p2gvpe8i 37 18 hypoxic hypoxic JJ cord-328396-p2gvpe8i 37 19 pulmonary pulmonary JJ cord-328396-p2gvpe8i 37 20 vasoconstriction vasoconstriction NN cord-328396-p2gvpe8i 37 21 ( ( -LRB- cord-328396-p2gvpe8i 37 22 HPV HPV NNP cord-328396-p2gvpe8i 37 23 ) ) -RRB- cord-328396-p2gvpe8i 37 24 and and CC cord-328396-p2gvpe8i 37 25 ventilation ventilation NN cord-328396-p2gvpe8i 37 26 / / SYM cord-328396-p2gvpe8i 37 27 perfusion perfusion NN cord-328396-p2gvpe8i 37 28 ( ( -LRB- cord-328396-p2gvpe8i 37 29 V v NN cord-328396-p2gvpe8i 37 30 / / SYM cord-328396-p2gvpe8i 37 31 Q q NN cord-328396-p2gvpe8i 37 32 ) ) -RRB- cord-328396-p2gvpe8i 37 33 mismatch mismatch NN cord-328396-p2gvpe8i 37 34 ( ( -LRB- cord-328396-p2gvpe8i 37 35 Gattinoni Gattinoni NNP cord-328396-p2gvpe8i 37 36 et et FW cord-328396-p2gvpe8i 37 37 al al NNP cord-328396-p2gvpe8i 37 38 . . NNP cord-328396-p2gvpe8i 37 39 , , , cord-328396-p2gvpe8i 37 40 2020 2020 CD cord-328396-p2gvpe8i 37 41 ) ) -RRB- cord-328396-p2gvpe8i 37 42 . . . cord-328396-p2gvpe8i 38 1 An an DT cord-328396-p2gvpe8i 38 2 impaired impaired JJ cord-328396-p2gvpe8i 38 3 HPV hpv NN cord-328396-p2gvpe8i 38 4 in in IN cord-328396-p2gvpe8i 38 5 these these DT cord-328396-p2gvpe8i 38 6 patients patient NNS cord-328396-p2gvpe8i 38 7 point point VBP cord-328396-p2gvpe8i 38 8 toward toward IN cord-328396-p2gvpe8i 38 9 mEC mec CD cord-328396-p2gvpe8i 38 10 dysfunction dysfunction NN cord-328396-p2gvpe8i 38 11 in in IN cord-328396-p2gvpe8i 38 12 the the DT cord-328396-p2gvpe8i 38 13 lungs lung NNS cord-328396-p2gvpe8i 38 14 as as IN cord-328396-p2gvpe8i 38 15 recent recent JJ cord-328396-p2gvpe8i 38 16 studies study NNS cord-328396-p2gvpe8i 38 17 have have VBP cord-328396-p2gvpe8i 38 18 postulated postulate VBN cord-328396-p2gvpe8i 38 19 that that IN cord-328396-p2gvpe8i 38 20 the the DT cord-328396-p2gvpe8i 38 21 alveolar alveolar NN cord-328396-p2gvpe8i 38 22 ion ion NN cord-328396-p2gvpe8i 38 23 channels channel NNS cord-328396-p2gvpe8i 38 24 in in IN cord-328396-p2gvpe8i 38 25 the the DT cord-328396-p2gvpe8i 38 26 endothelial endothelial JJ cord-328396-p2gvpe8i 38 27 cells cell NNS cord-328396-p2gvpe8i 38 28 of of IN cord-328396-p2gvpe8i 38 29 the the DT cord-328396-p2gvpe8i 38 30 alveolarcapillary alveolarcapillary JJ cord-328396-p2gvpe8i 38 31 barrier barrier NN cord-328396-p2gvpe8i 38 32 are be VBP cord-328396-p2gvpe8i 38 33 sensors sensor NNS cord-328396-p2gvpe8i 38 34 of of IN cord-328396-p2gvpe8i 38 35 oxygen oxygen NN cord-328396-p2gvpe8i 38 36 / / SYM cord-328396-p2gvpe8i 38 37 hypoxia hypoxia NN cord-328396-p2gvpe8i 38 38 that that WDT cord-328396-p2gvpe8i 38 39 propagate propagate VBP cord-328396-p2gvpe8i 38 40 the the DT cord-328396-p2gvpe8i 38 41 messages message NNS cord-328396-p2gvpe8i 38 42 along along IN cord-328396-p2gvpe8i 38 43 the the DT cord-328396-p2gvpe8i 38 44 vascular vascular JJ cord-328396-p2gvpe8i 38 45 endothelium endothelium NN cord-328396-p2gvpe8i 38 46 and and CC cord-328396-p2gvpe8i 38 47 initiate initiate VB cord-328396-p2gvpe8i 38 48 arteriolar arteriolar JJ cord-328396-p2gvpe8i 38 49 vasoconstriction vasoconstriction NN cord-328396-p2gvpe8i 38 50 or or CC cord-328396-p2gvpe8i 38 51 HPV hpv NN cord-328396-p2gvpe8i 38 52 ( ( -LRB- cord-328396-p2gvpe8i 38 53 Grimmer Grimmer NNP cord-328396-p2gvpe8i 38 54 and and CC cord-328396-p2gvpe8i 38 55 Kuebler Kuebler NNP cord-328396-p2gvpe8i 38 56 , , , cord-328396-p2gvpe8i 38 57 2017 2017 CD cord-328396-p2gvpe8i 38 58 ) ) -RRB- cord-328396-p2gvpe8i 38 59 . . . cord-328396-p2gvpe8i 39 1 These these DT cord-328396-p2gvpe8i 39 2 patients patient NNS cord-328396-p2gvpe8i 39 3 show show VBP cord-328396-p2gvpe8i 39 4 features feature NNS cord-328396-p2gvpe8i 39 5 of of IN cord-328396-p2gvpe8i 39 6 vasoplegia vasoplegia NN cord-328396-p2gvpe8i 39 7 or or CC cord-328396-p2gvpe8i 39 8 persistent persistent JJ cord-328396-p2gvpe8i 39 9 hypotension hypotension NN cord-328396-p2gvpe8i 39 10 as as IN cord-328396-p2gvpe8i 39 11 observed observe VBN cord-328396-p2gvpe8i 39 12 in in IN cord-328396-p2gvpe8i 39 13 sepsis sepsis NN cord-328396-p2gvpe8i 39 14 patients patient NNS cord-328396-p2gvpe8i 39 15 with with IN cord-328396-p2gvpe8i 39 16 atypical atypical JJ cord-328396-p2gvpe8i 39 17 ARDS ARDS NNP cord-328396-p2gvpe8i 39 18 , , , cord-328396-p2gvpe8i 39 19 indicative indicative JJ cord-328396-p2gvpe8i 39 20 of of IN cord-328396-p2gvpe8i 39 21 a a DT cord-328396-p2gvpe8i 39 22 primary primary JJ cord-328396-p2gvpe8i 39 23 insult insult NN cord-328396-p2gvpe8i 39 24 to to IN cord-328396-p2gvpe8i 39 25 the the DT cord-328396-p2gvpe8i 39 26 pulmonary pulmonary JJ cord-328396-p2gvpe8i 39 27 endothelium endothelium NN cord-328396-p2gvpe8i 39 28 ( ( -LRB- cord-328396-p2gvpe8i 40 1 Gattinoni Gattinoni NNP cord-328396-p2gvpe8i 40 2 et et NNP cord-328396-p2gvpe8i 40 3 al al NNP cord-328396-p2gvpe8i 40 4 . . NNP cord-328396-p2gvpe8i 40 5 , , , cord-328396-p2gvpe8i 40 6 2020 2020 CD cord-328396-p2gvpe8i 40 7 ) ) -RRB- cord-328396-p2gvpe8i 40 8 . . . cord-328396-p2gvpe8i 41 1 Lung lung NN cord-328396-p2gvpe8i 41 2 histology histology NN cord-328396-p2gvpe8i 41 3 in in IN cord-328396-p2gvpe8i 41 4 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 41 5 patients patient NNS cord-328396-p2gvpe8i 41 6 with with IN cord-328396-p2gvpe8i 41 7 severe severe JJ cord-328396-p2gvpe8i 41 8 respiratory respiratory JJ cord-328396-p2gvpe8i 41 9 failure failure NN cord-328396-p2gvpe8i 41 10 also also RB cord-328396-p2gvpe8i 41 11 indicates indicate VBZ cord-328396-p2gvpe8i 41 12 that that IN cord-328396-p2gvpe8i 41 13 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 41 14 has have VBZ cord-328396-p2gvpe8i 41 15 features feature VBZ cord-328396-p2gvpe8i 41 16 distinct distinct JJ cord-328396-p2gvpe8i 41 17 from from IN cord-328396-p2gvpe8i 41 18 typical typical JJ cord-328396-p2gvpe8i 41 19 ARDS ARDS NNP cord-328396-p2gvpe8i 41 20 ( ( -LRB- cord-328396-p2gvpe8i 42 1 Klok Klok NNP cord-328396-p2gvpe8i 42 2 et et NNP cord-328396-p2gvpe8i 42 3 al al NNP cord-328396-p2gvpe8i 42 4 . . NNP cord-328396-p2gvpe8i 42 5 , , , cord-328396-p2gvpe8i 42 6 2020 2020 CD cord-328396-p2gvpe8i 42 7 ) ) -RRB- cord-328396-p2gvpe8i 42 8 . . . cord-328396-p2gvpe8i 43 1 The the DT cord-328396-p2gvpe8i 43 2 pulmonary pulmonary JJ cord-328396-p2gvpe8i 43 3 abnormalities abnormality NNS cord-328396-p2gvpe8i 43 4 in in IN cord-328396-p2gvpe8i 43 5 these these DT cord-328396-p2gvpe8i 43 6 patients patient NNS cord-328396-p2gvpe8i 43 7 comprise comprise VBP cord-328396-p2gvpe8i 43 8 of of IN cord-328396-p2gvpe8i 43 9 thrombotic thrombotic JJ cord-328396-p2gvpe8i 43 10 microvascular microvascular JJ cord-328396-p2gvpe8i 43 11 injury injury NN cord-328396-p2gvpe8i 43 12 in in IN cord-328396-p2gvpe8i 43 13 the the DT cord-328396-p2gvpe8i 43 14 alveolar alveolar JJ cord-328396-p2gvpe8i 43 15 capillaries capillary NNS cord-328396-p2gvpe8i 43 16 , , , cord-328396-p2gvpe8i 43 17 with with IN cord-328396-p2gvpe8i 43 18 fewer few JJR cord-328396-p2gvpe8i 43 19 signs sign NNS cord-328396-p2gvpe8i 43 20 of of IN cord-328396-p2gvpe8i 43 21 viral viral JJ cord-328396-p2gvpe8i 43 22 cytopathic cytopathic JJ cord-328396-p2gvpe8i 43 23 or or CC cord-328396-p2gvpe8i 43 24 fibroproliferative fibroproliferative JJ cord-328396-p2gvpe8i 43 25 changes change NNS cord-328396-p2gvpe8i 43 26 . . . cord-328396-p2gvpe8i 44 1 Pulmonary pulmonary JJ cord-328396-p2gvpe8i 44 2 thromboembolic thromboembolic JJ cord-328396-p2gvpe8i 44 3 complications complication NNS cord-328396-p2gvpe8i 44 4 with with IN cord-328396-p2gvpe8i 44 5 a a DT cord-328396-p2gvpe8i 44 6 distinct distinct JJ cord-328396-p2gvpe8i 44 7 pro pro JJ cord-328396-p2gvpe8i 44 8 - - JJ cord-328396-p2gvpe8i 44 9 coagulant coagulant JJ cord-328396-p2gvpe8i 44 10 profile profile NN cord-328396-p2gvpe8i 44 11 , , , cord-328396-p2gvpe8i 44 12 elevated elevated JJ cord-328396-p2gvpe8i 44 13 D d NN cord-328396-p2gvpe8i 44 14 - - HYPH cord-328396-p2gvpe8i 44 15 dimer dimer NN cord-328396-p2gvpe8i 44 16 levels level NNS cord-328396-p2gvpe8i 44 17 and and CC cord-328396-p2gvpe8i 44 18 angiogenesis angiogenesis NN cord-328396-p2gvpe8i 44 19 is be VBZ cord-328396-p2gvpe8i 44 20 a a DT cord-328396-p2gvpe8i 44 21 common common JJ cord-328396-p2gvpe8i 44 22 finding finding NN cord-328396-p2gvpe8i 44 23 in in IN cord-328396-p2gvpe8i 44 24 many many JJ cord-328396-p2gvpe8i 44 25 severe severe JJ cord-328396-p2gvpe8i 44 26 cases case NNS cord-328396-p2gvpe8i 44 27 of of IN cord-328396-p2gvpe8i 44 28 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 44 29 patients patient NNS cord-328396-p2gvpe8i 44 30 ( ( -LRB- cord-328396-p2gvpe8i 44 31 Ackermann Ackermann NNP cord-328396-p2gvpe8i 44 32 et et NNP cord-328396-p2gvpe8i 44 33 al al NNP cord-328396-p2gvpe8i 44 34 . . . cord-328396-p2gvpe8i 45 1 , , , cord-328396-p2gvpe8i 45 2 2020 2020 CD cord-328396-p2gvpe8i 45 3 ; ; : cord-328396-p2gvpe8i 45 4 Ranucci Ranucci NNP cord-328396-p2gvpe8i 45 5 et et NNP cord-328396-p2gvpe8i 45 6 al al NNP cord-328396-p2gvpe8i 45 7 . . NNP cord-328396-p2gvpe8i 45 8 , , , cord-328396-p2gvpe8i 45 9 2020 2020 CD cord-328396-p2gvpe8i 45 10 ) ) -RRB- cord-328396-p2gvpe8i 45 11 . . . cord-328396-p2gvpe8i 46 1 Increased increase VBN cord-328396-p2gvpe8i 46 2 ratio ratio NN cord-328396-p2gvpe8i 46 3 of of IN cord-328396-p2gvpe8i 46 4 angiogenic angiogenic JJ cord-328396-p2gvpe8i 46 5 factor factor NN cord-328396-p2gvpe8i 46 6 , , , cord-328396-p2gvpe8i 46 7 soluble soluble JJ cord-328396-p2gvpe8i 46 8 fms fms NN cord-328396-p2gvpe8i 46 9 - - HYPH cord-328396-p2gvpe8i 46 10 like like JJ cord-328396-p2gvpe8i 46 11 tyrosine tyrosine NN cord-328396-p2gvpe8i 46 12 kinase kinase NN cord-328396-p2gvpe8i 46 13 1 1 CD cord-328396-p2gvpe8i 46 14 ( ( -LRB- cord-328396-p2gvpe8i 46 15 sFlt-1)/PLGF sFlt-1)/PLGF NNP cord-328396-p2gvpe8i 46 16 ( ( -LRB- cord-328396-p2gvpe8i 46 17 placental placental JJ cord-328396-p2gvpe8i 46 18 growth growth NN cord-328396-p2gvpe8i 46 19 factor factor NN cord-328396-p2gvpe8i 46 20 ) ) -RRB- cord-328396-p2gvpe8i 46 21 ratio ratio NN cord-328396-p2gvpe8i 46 22 in in IN cord-328396-p2gvpe8i 46 23 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 46 24 positive positive JJ cord-328396-p2gvpe8i 46 25 patients patient NNS cord-328396-p2gvpe8i 46 26 as as IN cord-328396-p2gvpe8i 46 27 compared compare VBN cord-328396-p2gvpe8i 46 28 to to IN cord-328396-p2gvpe8i 46 29 patients patient NNS cord-328396-p2gvpe8i 46 30 with with IN cord-328396-p2gvpe8i 46 31 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 46 32 negative negative JJ cord-328396-p2gvpe8i 46 33 pneumonia pneumonia NN cord-328396-p2gvpe8i 46 34 , , , cord-328396-p2gvpe8i 46 35 and and CC cord-328396-p2gvpe8i 46 36 healthy healthy JJ cord-328396-p2gvpe8i 46 37 donors donor NNS cord-328396-p2gvpe8i 46 38 is be VBZ cord-328396-p2gvpe8i 46 39 recently recently RB cord-328396-p2gvpe8i 46 40 documented document VBN cord-328396-p2gvpe8i 46 41 ( ( -LRB- cord-328396-p2gvpe8i 46 42 Giardini Giardini NNP cord-328396-p2gvpe8i 46 43 et et NNP cord-328396-p2gvpe8i 46 44 al al NNP cord-328396-p2gvpe8i 46 45 . . NNP cord-328396-p2gvpe8i 46 46 , , , cord-328396-p2gvpe8i 46 47 2020 2020 CD cord-328396-p2gvpe8i 46 48 ) ) -RRB- cord-328396-p2gvpe8i 46 49 . . . cord-328396-p2gvpe8i 47 1 The the DT cord-328396-p2gvpe8i 47 2 use use NN cord-328396-p2gvpe8i 47 3 of of IN cord-328396-p2gvpe8i 47 4 the the DT cord-328396-p2gvpe8i 47 5 s s NNP cord-328396-p2gvpe8i 47 6 - - HYPH cord-328396-p2gvpe8i 47 7 Flt1 Flt1 NNP cord-328396-p2gvpe8i 47 8 / / SYM cord-328396-p2gvpe8i 47 9 PlGF plgf NN cord-328396-p2gvpe8i 47 10 ratio ratio NN cord-328396-p2gvpe8i 47 11 in in IN cord-328396-p2gvpe8i 47 12 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 47 13 as as IN cord-328396-p2gvpe8i 47 14 a a DT cord-328396-p2gvpe8i 47 15 clinical clinical JJ cord-328396-p2gvpe8i 47 16 tool tool NN cord-328396-p2gvpe8i 47 17 to to TO cord-328396-p2gvpe8i 47 18 stratify stratify VB cord-328396-p2gvpe8i 47 19 the the DT cord-328396-p2gvpe8i 47 20 intensity intensity NN cord-328396-p2gvpe8i 47 21 of of IN cord-328396-p2gvpe8i 47 22 endothelial endothelial JJ cord-328396-p2gvpe8i 47 23 dysfunction dysfunction NN cord-328396-p2gvpe8i 47 24 has have VBZ cord-328396-p2gvpe8i 47 25 been be VBN cord-328396-p2gvpe8i 47 26 proposed propose VBN cord-328396-p2gvpe8i 47 27 in in IN cord-328396-p2gvpe8i 47 28 this this DT cord-328396-p2gvpe8i 47 29 study study NN cord-328396-p2gvpe8i 47 30 . . . cord-328396-p2gvpe8i 48 1 A a DT cord-328396-p2gvpe8i 48 2 healthy healthy JJ cord-328396-p2gvpe8i 48 3 lung lung NN cord-328396-p2gvpe8i 48 4 endothelium endothelium NN cord-328396-p2gvpe8i 48 5 has have VBZ cord-328396-p2gvpe8i 48 6 an an DT cord-328396-p2gvpe8i 48 7 inhibitory inhibitory JJ cord-328396-p2gvpe8i 48 8 effect effect NN cord-328396-p2gvpe8i 48 9 on on IN cord-328396-p2gvpe8i 48 10 inflammation inflammation NN cord-328396-p2gvpe8i 48 11 and and CC cord-328396-p2gvpe8i 48 12 coagulation coagulation NN cord-328396-p2gvpe8i 48 13 while while IN cord-328396-p2gvpe8i 48 14 a a DT cord-328396-p2gvpe8i 48 15 procoagulant procoagulant JJ cord-328396-p2gvpe8i 48 16 phenotype phenotype NN cord-328396-p2gvpe8i 48 17 is be VBZ cord-328396-p2gvpe8i 48 18 a a DT cord-328396-p2gvpe8i 48 19 hallmark hallmark NN cord-328396-p2gvpe8i 48 20 of of IN cord-328396-p2gvpe8i 48 21 an an DT cord-328396-p2gvpe8i 48 22 injured injured JJ cord-328396-p2gvpe8i 48 23 endothelium endothelium NN cord-328396-p2gvpe8i 48 24 in in IN cord-328396-p2gvpe8i 48 25 sepsis sepsis NN cord-328396-p2gvpe8i 48 26 and and CC cord-328396-p2gvpe8i 48 27 ARDS ARDS NNP cord-328396-p2gvpe8i 48 28 both both DT cord-328396-p2gvpe8i 49 1 ( ( -LRB- cord-328396-p2gvpe8i 49 2 Millar Millar NNP cord-328396-p2gvpe8i 49 3 et et NNP cord-328396-p2gvpe8i 49 4 al al NNP cord-328396-p2gvpe8i 49 5 . . NNP cord-328396-p2gvpe8i 49 6 , , , cord-328396-p2gvpe8i 49 7 2016 2016 CD cord-328396-p2gvpe8i 49 8 ) ) -RRB- cord-328396-p2gvpe8i 49 9 . . . cord-328396-p2gvpe8i 50 1 These these DT cord-328396-p2gvpe8i 50 2 studies study NNS cord-328396-p2gvpe8i 50 3 along along IN cord-328396-p2gvpe8i 50 4 with with IN cord-328396-p2gvpe8i 50 5 the the DT cord-328396-p2gvpe8i 50 6 fact fact NN cord-328396-p2gvpe8i 50 7 that that IN cord-328396-p2gvpe8i 50 8 the the DT cord-328396-p2gvpe8i 50 9 pulmonary pulmonary JJ cord-328396-p2gvpe8i 50 10 epithelium epithelium NN cord-328396-p2gvpe8i 50 11 is be VBZ cord-328396-p2gvpe8i 50 12 more more RBR cord-328396-p2gvpe8i 50 13 resistant resistant JJ cord-328396-p2gvpe8i 50 14 to to IN cord-328396-p2gvpe8i 50 15 injury injury NN cord-328396-p2gvpe8i 50 16 than than IN cord-328396-p2gvpe8i 50 17 the the DT cord-328396-p2gvpe8i 50 18 endothelium endothelium NN cord-328396-p2gvpe8i 50 19 signify signify RB cord-328396-p2gvpe8i 50 20 that that IN cord-328396-p2gvpe8i 50 21 SARS SARS NNP cord-328396-p2gvpe8i 50 22 - - HYPH cord-328396-p2gvpe8i 50 23 CoV-2-induced cov-2-induce VBN cord-328396-p2gvpe8i 50 24 ARDS ARDS NNP cord-328396-p2gvpe8i 50 25 and and CC cord-328396-p2gvpe8i 50 26 associated associated JJ cord-328396-p2gvpe8i 50 27 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 50 28 may may MD cord-328396-p2gvpe8i 50 29 be be VB cord-328396-p2gvpe8i 50 30 caused cause VBN cord-328396-p2gvpe8i 50 31 by by IN cord-328396-p2gvpe8i 50 32 a a DT cord-328396-p2gvpe8i 50 33 direct direct JJ cord-328396-p2gvpe8i 50 34 endothelial endothelial JJ cord-328396-p2gvpe8i 50 35 infection infection NN cord-328396-p2gvpe8i 50 36 by by IN cord-328396-p2gvpe8i 50 37 the the DT cord-328396-p2gvpe8i 50 38 virus virus NN cord-328396-p2gvpe8i 50 39 in in IN cord-328396-p2gvpe8i 50 40 the the DT cord-328396-p2gvpe8i 50 41 lungs lung NNS cord-328396-p2gvpe8i 50 42 ( ( -LRB- cord-328396-p2gvpe8i 50 43 Matthay Matthay NNP cord-328396-p2gvpe8i 50 44 et et FW cord-328396-p2gvpe8i 50 45 al al NNP cord-328396-p2gvpe8i 50 46 . . NNP cord-328396-p2gvpe8i 50 47 , , , cord-328396-p2gvpe8i 50 48 2019 2019 CD cord-328396-p2gvpe8i 50 49 ) ) -RRB- cord-328396-p2gvpe8i 50 50 . . . cord-328396-p2gvpe8i 51 1 Another another DT cord-328396-p2gvpe8i 51 2 study study NN cord-328396-p2gvpe8i 51 3 on on IN cord-328396-p2gvpe8i 51 4 a a DT cord-328396-p2gvpe8i 51 5 few few JJ cord-328396-p2gvpe8i 51 6 post post JJ cord-328396-p2gvpe8i 51 7 - - JJ cord-328396-p2gvpe8i 51 8 mortem mortem JJ cord-328396-p2gvpe8i 51 9 biopsies biopsy NNS cord-328396-p2gvpe8i 51 10 has have VBZ cord-328396-p2gvpe8i 51 11 , , , cord-328396-p2gvpe8i 51 12 however however RB cord-328396-p2gvpe8i 51 13 , , , cord-328396-p2gvpe8i 51 14 illustrated illustrate VBD cord-328396-p2gvpe8i 51 15 that that IN cord-328396-p2gvpe8i 51 16 SARS SARS NNP cord-328396-p2gvpe8i 51 17 - - HYPH cord-328396-p2gvpe8i 51 18 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 51 19 nucleocapsid nucleocapsid NN cord-328396-p2gvpe8i 51 20 protein protein NN cord-328396-p2gvpe8i 51 21 immunopositivity immunopositivity NNP cord-328396-p2gvpe8i 51 22 is be VBZ cord-328396-p2gvpe8i 51 23 not not RB cord-328396-p2gvpe8i 51 24 observed observe VBN cord-328396-p2gvpe8i 51 25 in in IN cord-328396-p2gvpe8i 51 26 the the DT cord-328396-p2gvpe8i 51 27 mECs mecs NN cord-328396-p2gvpe8i 51 28 and and CC cord-328396-p2gvpe8i 51 29 is be VBZ cord-328396-p2gvpe8i 51 30 present present JJ cord-328396-p2gvpe8i 51 31 only only RB cord-328396-p2gvpe8i 51 32 in in IN cord-328396-p2gvpe8i 51 33 lung lung NN cord-328396-p2gvpe8i 51 34 pneumocytes pneumocyte NNS cord-328396-p2gvpe8i 51 35 and and CC cord-328396-p2gvpe8i 51 36 ciliated ciliated JJ cord-328396-p2gvpe8i 51 37 epithelial epithelial JJ cord-328396-p2gvpe8i 51 38 cells cell NNS cord-328396-p2gvpe8i 51 39 ( ( -LRB- cord-328396-p2gvpe8i 52 1 Schaefer Schaefer NNP cord-328396-p2gvpe8i 52 2 et et NNP cord-328396-p2gvpe8i 52 3 al al NNP cord-328396-p2gvpe8i 52 4 . . NNP cord-328396-p2gvpe8i 52 5 , , , cord-328396-p2gvpe8i 52 6 2020 2020 CD cord-328396-p2gvpe8i 52 7 ) ) -RRB- cord-328396-p2gvpe8i 52 8 . . . cord-328396-p2gvpe8i 53 1 Interestingly interestingly RB cord-328396-p2gvpe8i 53 2 , , , cord-328396-p2gvpe8i 53 3 in in IN cord-328396-p2gvpe8i 53 4 this this DT cord-328396-p2gvpe8i 53 5 study study NN cord-328396-p2gvpe8i 53 6 , , , cord-328396-p2gvpe8i 53 7 five five CD cord-328396-p2gvpe8i 53 8 patients patient NNS cord-328396-p2gvpe8i 53 9 also also RB cord-328396-p2gvpe8i 53 10 exhibit exhibit VBP cord-328396-p2gvpe8i 53 11 blood blood NN cord-328396-p2gvpe8i 53 12 clots clot NNS cord-328396-p2gvpe8i 53 13 in in IN cord-328396-p2gvpe8i 53 14 the the DT cord-328396-p2gvpe8i 53 15 pulmonary pulmonary JJ cord-328396-p2gvpe8i 53 16 vasculature vasculature NN cord-328396-p2gvpe8i 53 17 . . . cord-328396-p2gvpe8i 54 1 In in IN cord-328396-p2gvpe8i 54 2 absence absence NN cord-328396-p2gvpe8i 54 3 of of IN cord-328396-p2gvpe8i 54 4 a a DT cord-328396-p2gvpe8i 54 5 direct direct JJ cord-328396-p2gvpe8i 54 6 pulmonary pulmonary JJ cord-328396-p2gvpe8i 54 7 endothelial endothelial JJ cord-328396-p2gvpe8i 54 8 involvement involvement NN cord-328396-p2gvpe8i 54 9 and and CC cord-328396-p2gvpe8i 54 10 viral viral JJ cord-328396-p2gvpe8i 54 11 infection infection NN cord-328396-p2gvpe8i 54 12 , , , cord-328396-p2gvpe8i 54 13 this this DT cord-328396-p2gvpe8i 54 14 may may MD cord-328396-p2gvpe8i 54 15 be be VB cord-328396-p2gvpe8i 54 16 explained explain VBN cord-328396-p2gvpe8i 54 17 as as IN cord-328396-p2gvpe8i 54 18 diffuse diffuse JJ cord-328396-p2gvpe8i 54 19 pulmonary pulmonary JJ cord-328396-p2gvpe8i 54 20 intravascular intravascular JJ cord-328396-p2gvpe8i 54 21 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 54 22 , , , cord-328396-p2gvpe8i 54 23 which which WDT cord-328396-p2gvpe8i 54 24 is be VBZ cord-328396-p2gvpe8i 54 25 distinct distinct JJ cord-328396-p2gvpe8i 54 26 from from IN cord-328396-p2gvpe8i 54 27 sepsis sepsis NN cord-328396-p2gvpe8i 54 28 - - HYPH cord-328396-p2gvpe8i 54 29 induced induce VBN cord-328396-p2gvpe8i 54 30 disseminated disseminate VBD cord-328396-p2gvpe8i 54 31 intravascular intravascular JJ cord-328396-p2gvpe8i 54 32 coagulation coagulation NN cord-328396-p2gvpe8i 54 33 ( ( -LRB- cord-328396-p2gvpe8i 54 34 Marchandot Marchandot NNP cord-328396-p2gvpe8i 54 35 et et NNP cord-328396-p2gvpe8i 54 36 al al NNP cord-328396-p2gvpe8i 54 37 . . NNP cord-328396-p2gvpe8i 54 38 , , , cord-328396-p2gvpe8i 54 39 2020 2020 CD cord-328396-p2gvpe8i 54 40 ; ; : cord-328396-p2gvpe8i 54 41 McGonagle McGonagle NNP cord-328396-p2gvpe8i 54 42 et et NNP cord-328396-p2gvpe8i 54 43 al al NNP cord-328396-p2gvpe8i 54 44 . . NNP cord-328396-p2gvpe8i 54 45 , , , cord-328396-p2gvpe8i 54 46 2020 2020 CD cord-328396-p2gvpe8i 54 47 ) ) -RRB- cord-328396-p2gvpe8i 54 48 . . . cord-328396-p2gvpe8i 55 1 However however RB cord-328396-p2gvpe8i 55 2 , , , cord-328396-p2gvpe8i 55 3 an an DT cord-328396-p2gvpe8i 55 4 absence absence NN cord-328396-p2gvpe8i 55 5 of of IN cord-328396-p2gvpe8i 55 6 viral viral JJ cord-328396-p2gvpe8i 55 7 positivity positivity NN cord-328396-p2gvpe8i 55 8 in in IN cord-328396-p2gvpe8i 55 9 the the DT cord-328396-p2gvpe8i 55 10 mECs mecs NN cord-328396-p2gvpe8i 55 11 in in IN cord-328396-p2gvpe8i 55 12 this this DT cord-328396-p2gvpe8i 55 13 study study NN cord-328396-p2gvpe8i 55 14 can can MD cord-328396-p2gvpe8i 55 15 also also RB cord-328396-p2gvpe8i 55 16 be be VB cord-328396-p2gvpe8i 55 17 attributed attribute VBN cord-328396-p2gvpe8i 55 18 to to IN cord-328396-p2gvpe8i 55 19 technical technical JJ cord-328396-p2gvpe8i 55 20 limitations limitation NNS cord-328396-p2gvpe8i 55 21 . . . cord-328396-p2gvpe8i 56 1 Further further JJ cord-328396-p2gvpe8i 56 2 studies study NNS cord-328396-p2gvpe8i 56 3 and and CC cord-328396-p2gvpe8i 56 4 sensitive sensitive JJ cord-328396-p2gvpe8i 56 5 imaging imaging NN cord-328396-p2gvpe8i 56 6 techniques technique NNS cord-328396-p2gvpe8i 56 7 are be VBP cord-328396-p2gvpe8i 56 8 needed need VBN cord-328396-p2gvpe8i 56 9 to to TO cord-328396-p2gvpe8i 56 10 delineate delineate VB cord-328396-p2gvpe8i 56 11 if if IN cord-328396-p2gvpe8i 56 12 SARS SARS NNP cord-328396-p2gvpe8i 56 13 - - HYPH cord-328396-p2gvpe8i 56 14 CoV2 CoV2 NNP cord-328396-p2gvpe8i 56 15 causes cause VBZ cord-328396-p2gvpe8i 56 16 a a DT cord-328396-p2gvpe8i 56 17 direct direct JJ cord-328396-p2gvpe8i 56 18 endothelial endothelial JJ cord-328396-p2gvpe8i 56 19 injury injury NN cord-328396-p2gvpe8i 56 20 as as IN cord-328396-p2gvpe8i 56 21 seen see VBN cord-328396-p2gvpe8i 56 22 in in IN cord-328396-p2gvpe8i 56 23 sepsis sepsis NN cord-328396-p2gvpe8i 56 24 - - HYPH cord-328396-p2gvpe8i 56 25 induced induce VBN cord-328396-p2gvpe8i 56 26 ARDS ARDS NNP cord-328396-p2gvpe8i 56 27 or or CC cord-328396-p2gvpe8i 56 28 a a DT cord-328396-p2gvpe8i 56 29 direct direct JJ cord-328396-p2gvpe8i 56 30 epithelial epithelial JJ cord-328396-p2gvpe8i 56 31 injury injury NN cord-328396-p2gvpe8i 56 32 as as IN cord-328396-p2gvpe8i 56 33 in in IN cord-328396-p2gvpe8i 56 34 typical typical JJ cord-328396-p2gvpe8i 56 35 ARDS ARDS NNP cord-328396-p2gvpe8i 56 36 . . . cord-328396-p2gvpe8i 57 1 Both both CC cord-328396-p2gvpe8i 57 2 these these DT cord-328396-p2gvpe8i 57 3 conditions condition NNS cord-328396-p2gvpe8i 57 4 have have VBP cord-328396-p2gvpe8i 57 5 different different JJ cord-328396-p2gvpe8i 57 6 pathological pathological JJ cord-328396-p2gvpe8i 57 7 hallmarks hallmark NNS cord-328396-p2gvpe8i 57 8 and and CC cord-328396-p2gvpe8i 57 9 hence hence RB cord-328396-p2gvpe8i 57 10 can can MD cord-328396-p2gvpe8i 57 11 be be VB cord-328396-p2gvpe8i 57 12 dissected dissect VBN cord-328396-p2gvpe8i 57 13 . . . cord-328396-p2gvpe8i 58 1 A a DT cord-328396-p2gvpe8i 58 2 direct direct JJ cord-328396-p2gvpe8i 58 3 endothelial endothelial JJ cord-328396-p2gvpe8i 58 4 injury injury NN cord-328396-p2gvpe8i 58 5 can can MD cord-328396-p2gvpe8i 58 6 be be VB cord-328396-p2gvpe8i 58 7 characterized characterize VBN cord-328396-p2gvpe8i 58 8 by by IN cord-328396-p2gvpe8i 58 9 increased increase VBN cord-328396-p2gvpe8i 58 10 levels level NNS cord-328396-p2gvpe8i 58 11 of of IN cord-328396-p2gvpe8i 58 12 Angiopoetin-2 Angiopoetin-2 NNP cord-328396-p2gvpe8i 58 13 , , , cord-328396-p2gvpe8i 58 14 von von NNP cord-328396-p2gvpe8i 58 15 Willebrand Willebrand NNP cord-328396-p2gvpe8i 58 16 factor factor NN cord-328396-p2gvpe8i 58 17 ( ( -LRB- cord-328396-p2gvpe8i 58 18 vWF vWF NNP cord-328396-p2gvpe8i 58 19 ) ) -RRB- cord-328396-p2gvpe8i 58 20 , , , cord-328396-p2gvpe8i 58 21 Soluble soluble JJ cord-328396-p2gvpe8i 58 22 thrombomodulin thrombomodulin NN cord-328396-p2gvpe8i 58 23 , , , cord-328396-p2gvpe8i 58 24 Interleukin Interleukin NNP cord-328396-p2gvpe8i 58 25 8 8 CD cord-328396-p2gvpe8i 58 26 , , , cord-328396-p2gvpe8i 58 27 Soluble soluble JJ cord-328396-p2gvpe8i 58 28 ICAM-1 ICAM-1 NNP cord-328396-p2gvpe8i 58 29 indicating indicate VBG cord-328396-p2gvpe8i 58 30 massive massive JJ cord-328396-p2gvpe8i 58 31 endothelial endothelial JJ cord-328396-p2gvpe8i 58 32 stimulation stimulation NN cord-328396-p2gvpe8i 58 33 and and CC cord-328396-p2gvpe8i 58 34 damage damage NN cord-328396-p2gvpe8i 58 35 , , , cord-328396-p2gvpe8i 58 36 while while IN cord-328396-p2gvpe8i 58 37 direct direct JJ cord-328396-p2gvpe8i 58 38 epithelial epithelial JJ cord-328396-p2gvpe8i 58 39 injury injury NN cord-328396-p2gvpe8i 58 40 can can MD cord-328396-p2gvpe8i 58 41 be be VB cord-328396-p2gvpe8i 58 42 identified identify VBN cord-328396-p2gvpe8i 58 43 by by IN cord-328396-p2gvpe8i 58 44 high high JJ cord-328396-p2gvpe8i 58 45 plasma plasma NN cord-328396-p2gvpe8i 58 46 levels level NNS cord-328396-p2gvpe8i 58 47 of of IN cord-328396-p2gvpe8i 58 48 surfactant surfactant NN cord-328396-p2gvpe8i 58 49 protein protein NN cord-328396-p2gvpe8i 58 50 - - HYPH cord-328396-p2gvpe8i 58 51 D d NN cord-328396-p2gvpe8i 58 52 and and CC cord-328396-p2gvpe8i 58 53 receptor receptor NN cord-328396-p2gvpe8i 58 54 for for IN cord-328396-p2gvpe8i 58 55 advanced advanced JJ cord-328396-p2gvpe8i 58 56 glycation glycation NN cord-328396-p2gvpe8i 58 57 end end NN cord-328396-p2gvpe8i 58 58 products product NNS cord-328396-p2gvpe8i 58 59 ( ( -LRB- cord-328396-p2gvpe8i 58 60 Hendrickson Hendrickson NNP cord-328396-p2gvpe8i 58 61 and and CC cord-328396-p2gvpe8i 58 62 Matthay Matthay NNP cord-328396-p2gvpe8i 58 63 , , , cord-328396-p2gvpe8i 58 64 2018 2018 CD cord-328396-p2gvpe8i 58 65 ) ) -RRB- cord-328396-p2gvpe8i 58 66 . . . cord-328396-p2gvpe8i 59 1 In in IN cord-328396-p2gvpe8i 59 2 case case NN cord-328396-p2gvpe8i 59 3 of of IN cord-328396-p2gvpe8i 59 4 direct direct JJ cord-328396-p2gvpe8i 59 5 injury injury NN cord-328396-p2gvpe8i 59 6 to to IN cord-328396-p2gvpe8i 59 7 mEC mEC NNP cord-328396-p2gvpe8i 59 8 , , , cord-328396-p2gvpe8i 59 9 SARS SARS NNP cord-328396-p2gvpe8i 59 10 - - HYPH cord-328396-p2gvpe8i 59 11 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 59 12 should should MD cord-328396-p2gvpe8i 59 13 enter enter VB cord-328396-p2gvpe8i 59 14 the the DT cord-328396-p2gvpe8i 59 15 lungs lung NNS cord-328396-p2gvpe8i 59 16 via via IN cord-328396-p2gvpe8i 59 17 the the DT cord-328396-p2gvpe8i 59 18 mECs mecs NN cord-328396-p2gvpe8i 59 19 . . . cord-328396-p2gvpe8i 60 1 Angiotensin angiotensin NN cord-328396-p2gvpe8i 60 2 - - HYPH cord-328396-p2gvpe8i 60 3 converting convert VBG cord-328396-p2gvpe8i 60 4 enzyme enzyme NN cord-328396-p2gvpe8i 60 5 2 2 CD cord-328396-p2gvpe8i 60 6 ( ( -LRB- cord-328396-p2gvpe8i 60 7 ACE2 ACE2 NNP cord-328396-p2gvpe8i 60 8 ) ) -RRB- cord-328396-p2gvpe8i 60 9 , , , cord-328396-p2gvpe8i 60 10 the the DT cord-328396-p2gvpe8i 60 11 type type NN cord-328396-p2gvpe8i 60 12 I -PRON- PRP cord-328396-p2gvpe8i 60 13 integral integral VBP cord-328396-p2gvpe8i 60 14 transmembrane transmembrane NN cord-328396-p2gvpe8i 60 15 protein protein NN cord-328396-p2gvpe8i 60 16 , , , cord-328396-p2gvpe8i 60 17 a a DT cord-328396-p2gvpe8i 60 18 functional functional JJ cord-328396-p2gvpe8i 60 19 receptor receptor NN cord-328396-p2gvpe8i 60 20 for for IN cord-328396-p2gvpe8i 60 21 SARS SARS NNP cord-328396-p2gvpe8i 60 22 - - HYPH cord-328396-p2gvpe8i 60 23 CoV CoV NNP cord-328396-p2gvpe8i 60 24 and and CC cord-328396-p2gvpe8i 60 25 a a DT cord-328396-p2gvpe8i 60 26 potential potential JJ cord-328396-p2gvpe8i 60 27 receptor receptor NN cord-328396-p2gvpe8i 60 28 for for IN cord-328396-p2gvpe8i 60 29 SARS SARS NNP cord-328396-p2gvpe8i 60 30 - - HYPH cord-328396-p2gvpe8i 60 31 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 60 32 is be VBZ cord-328396-p2gvpe8i 60 33 highly highly RB cord-328396-p2gvpe8i 60 34 expressed express VBN cord-328396-p2gvpe8i 60 35 in in IN cord-328396-p2gvpe8i 60 36 the the DT cord-328396-p2gvpe8i 60 37 mEC mec NN cord-328396-p2gvpe8i 60 38 , , , cord-328396-p2gvpe8i 60 39 along along IN cord-328396-p2gvpe8i 60 40 with with IN cord-328396-p2gvpe8i 60 41 the the DT cord-328396-p2gvpe8i 60 42 lung lung NN cord-328396-p2gvpe8i 60 43 epithelial epithelial NN cord-328396-p2gvpe8i 60 44 cells cell NNS cord-328396-p2gvpe8i 60 45 ( ( -LRB- cord-328396-p2gvpe8i 60 46 Hamming ham VBG cord-328396-p2gvpe8i 60 47 et et FW cord-328396-p2gvpe8i 60 48 al al NNP cord-328396-p2gvpe8i 60 49 . . NNP cord-328396-p2gvpe8i 60 50 , , , cord-328396-p2gvpe8i 60 51 2004 2004 CD cord-328396-p2gvpe8i 60 52 ; ; : cord-328396-p2gvpe8i 60 53 Hoffmann Hoffmann NNP cord-328396-p2gvpe8i 60 54 et et NNP cord-328396-p2gvpe8i 60 55 al al NNP cord-328396-p2gvpe8i 60 56 . . NNP cord-328396-p2gvpe8i 60 57 , , , cord-328396-p2gvpe8i 60 58 2020 2020 CD cord-328396-p2gvpe8i 60 59 ) ) -RRB- cord-328396-p2gvpe8i 60 60 . . . cord-328396-p2gvpe8i 61 1 Although although IN cord-328396-p2gvpe8i 61 2 the the DT cord-328396-p2gvpe8i 61 3 contribution contribution NN cord-328396-p2gvpe8i 61 4 of of IN cord-328396-p2gvpe8i 61 5 ACE2 ACE2 NNP cord-328396-p2gvpe8i 61 6 in in IN cord-328396-p2gvpe8i 61 7 the the DT cord-328396-p2gvpe8i 61 8 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 61 9 of of IN cord-328396-p2gvpe8i 61 10 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 61 11 is be VBZ cord-328396-p2gvpe8i 61 12 not not RB cord-328396-p2gvpe8i 61 13 known know VBN cord-328396-p2gvpe8i 61 14 , , , cord-328396-p2gvpe8i 61 15 yet yet CC cord-328396-p2gvpe8i 61 16 it -PRON- PRP cord-328396-p2gvpe8i 61 17 has have VBZ cord-328396-p2gvpe8i 61 18 been be VBN cord-328396-p2gvpe8i 61 19 delineated delineate VBN cord-328396-p2gvpe8i 61 20 that that IN cord-328396-p2gvpe8i 61 21 SARS SARS NNP cord-328396-p2gvpe8i 61 22 - - HYPH cord-328396-p2gvpe8i 61 23 CoV CoV NNP cord-328396-p2gvpe8i 61 24 infection infection NN cord-328396-p2gvpe8i 61 25 downregulates downregulate VBZ cord-328396-p2gvpe8i 61 26 ACE2 ACE2 NNP cord-328396-p2gvpe8i 61 27 and and CC cord-328396-p2gvpe8i 61 28 worsens worsen VBZ cord-328396-p2gvpe8i 61 29 lung lung NN cord-328396-p2gvpe8i 61 30 injury injury NN cord-328396-p2gvpe8i 61 31 that that WDT cord-328396-p2gvpe8i 61 32 is be VBZ cord-328396-p2gvpe8i 61 33 reversed reverse VBN cord-328396-p2gvpe8i 61 34 by by IN cord-328396-p2gvpe8i 61 35 treatment treatment NN cord-328396-p2gvpe8i 61 36 with with IN cord-328396-p2gvpe8i 61 37 Angiotensin Angiotensin NNP cord-328396-p2gvpe8i 61 38 receptor receptor NN cord-328396-p2gvpe8i 61 39 blockermediated blockermediate VBN cord-328396-p2gvpe8i 61 40 upregulation upregulation NN cord-328396-p2gvpe8i 61 41 of of IN cord-328396-p2gvpe8i 61 42 ACE2 ACE2 NNP cord-328396-p2gvpe8i 61 43 ( ( -LRB- cord-328396-p2gvpe8i 62 1 Imai Imai NNP cord-328396-p2gvpe8i 62 2 et et NNP cord-328396-p2gvpe8i 62 3 al al NNP cord-328396-p2gvpe8i 62 4 . . NNP cord-328396-p2gvpe8i 62 5 , , , cord-328396-p2gvpe8i 62 6 2005 2005 CD cord-328396-p2gvpe8i 62 7 ) ) -RRB- cord-328396-p2gvpe8i 62 8 . . . cord-328396-p2gvpe8i 63 1 This this DT cord-328396-p2gvpe8i 63 2 study study NN cord-328396-p2gvpe8i 63 3 and and CC cord-328396-p2gvpe8i 63 4 several several JJ cord-328396-p2gvpe8i 63 5 others other NNS cord-328396-p2gvpe8i 63 6 show show VBP cord-328396-p2gvpe8i 63 7 a a DT cord-328396-p2gvpe8i 63 8 protective protective JJ cord-328396-p2gvpe8i 63 9 role role NN cord-328396-p2gvpe8i 63 10 of of IN cord-328396-p2gvpe8i 63 11 ACE2 ACE2 NNP cord-328396-p2gvpe8i 63 12 in in IN cord-328396-p2gvpe8i 63 13 ARDS ARDS NNP cord-328396-p2gvpe8i 63 14 and and CC cord-328396-p2gvpe8i 63 15 lung lung NN cord-328396-p2gvpe8i 63 16 injury injury NN cord-328396-p2gvpe8i 63 17 . . . cord-328396-p2gvpe8i 64 1 A a DT cord-328396-p2gvpe8i 64 2 recent recent JJ cord-328396-p2gvpe8i 64 3 study study NN cord-328396-p2gvpe8i 64 4 has have VBZ cord-328396-p2gvpe8i 64 5 also also RB cord-328396-p2gvpe8i 64 6 revealed reveal VBN cord-328396-p2gvpe8i 64 7 that that IN cord-328396-p2gvpe8i 64 8 the the DT cord-328396-p2gvpe8i 64 9 use use NN cord-328396-p2gvpe8i 64 10 of of IN cord-328396-p2gvpe8i 64 11 human human JJ cord-328396-p2gvpe8i 64 12 recombinant recombinant NN cord-328396-p2gvpe8i 64 13 soluble soluble JJ cord-328396-p2gvpe8i 64 14 ACE2 ACE2 NNP cord-328396-p2gvpe8i 64 15 prevented prevent VBD cord-328396-p2gvpe8i 64 16 host host NN cord-328396-p2gvpe8i 64 17 cell cell NN cord-328396-p2gvpe8i 64 18 binding bind VBG cord-328396-p2gvpe8i 64 19 to to IN cord-328396-p2gvpe8i 64 20 SARS SARS NNP cord-328396-p2gvpe8i 64 21 - - HYPH cord-328396-p2gvpe8i 64 22 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 64 23 , , , cord-328396-p2gvpe8i 64 24 probably probably RB cord-328396-p2gvpe8i 64 25 by by IN cord-328396-p2gvpe8i 64 26 viral viral JJ cord-328396-p2gvpe8i 64 27 binding binding NN cord-328396-p2gvpe8i 64 28 to to IN cord-328396-p2gvpe8i 64 29 proteins protein NNS cord-328396-p2gvpe8i 64 30 in in IN cord-328396-p2gvpe8i 64 31 solution solution NN cord-328396-p2gvpe8i 64 32 rather rather RB cord-328396-p2gvpe8i 64 33 than than IN cord-328396-p2gvpe8i 64 34 those those DT cord-328396-p2gvpe8i 64 35 on on IN cord-328396-p2gvpe8i 64 36 host host NN cord-328396-p2gvpe8i 64 37 cells cell NNS cord-328396-p2gvpe8i 64 38 ( ( -LRB- cord-328396-p2gvpe8i 64 39 Monteil Monteil NNP cord-328396-p2gvpe8i 64 40 et et NNP cord-328396-p2gvpe8i 64 41 al al NNP cord-328396-p2gvpe8i 64 42 . . NNP cord-328396-p2gvpe8i 64 43 , , , cord-328396-p2gvpe8i 64 44 2020 2020 CD cord-328396-p2gvpe8i 64 45 ) ) -RRB- cord-328396-p2gvpe8i 64 46 . . . cord-328396-p2gvpe8i 65 1 However however RB cord-328396-p2gvpe8i 65 2 , , , cord-328396-p2gvpe8i 65 3 the the DT cord-328396-p2gvpe8i 65 4 precise precise JJ cord-328396-p2gvpe8i 65 5 in in IN cord-328396-p2gvpe8i 65 6 vivo vivo NN cord-328396-p2gvpe8i 65 7 role role NN cord-328396-p2gvpe8i 65 8 of of IN cord-328396-p2gvpe8i 65 9 mEC mec NN cord-328396-p2gvpe8i 65 10 - - HYPH cord-328396-p2gvpe8i 65 11 specific specific JJ cord-328396-p2gvpe8i 65 12 ACE2 ACE2 NNP cord-328396-p2gvpe8i 65 13 vis vis FW cord-328396-p2gvpe8i 65 14 - - HYPH cord-328396-p2gvpe8i 65 15 à à FW cord-328396-p2gvpe8i 65 16 - - HYPH cord-328396-p2gvpe8i 65 17 vis vis FW cord-328396-p2gvpe8i 65 18 circulating circulate VBG cord-328396-p2gvpe8i 65 19 ACE2 ACE2 NNP cord-328396-p2gvpe8i 65 20 levels level NNS cord-328396-p2gvpe8i 65 21 in in IN cord-328396-p2gvpe8i 65 22 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 65 23 infection infection NN cord-328396-p2gvpe8i 65 24 and/or and/or CC cord-328396-p2gvpe8i 65 25 severity severity NN cord-328396-p2gvpe8i 65 26 , , , cord-328396-p2gvpe8i 65 27 especially especially RB cord-328396-p2gvpe8i 65 28 in in IN cord-328396-p2gvpe8i 65 29 context context NN cord-328396-p2gvpe8i 65 30 of of IN cord-328396-p2gvpe8i 65 31 their -PRON- PRP$ cord-328396-p2gvpe8i 65 32 vascular vascular JJ cord-328396-p2gvpe8i 65 33 effects effect NNS cord-328396-p2gvpe8i 65 34 demand demand VBP cord-328396-p2gvpe8i 65 35 stringent stringent JJ cord-328396-p2gvpe8i 65 36 evidencebased evidencebase VBN cord-328396-p2gvpe8i 65 37 studies study NNS cord-328396-p2gvpe8i 65 38 . . . cord-328396-p2gvpe8i 66 1 Besides besides IN cord-328396-p2gvpe8i 66 2 ACE2 ACE2 NNP cord-328396-p2gvpe8i 66 3 , , , cord-328396-p2gvpe8i 66 4 other other JJ cord-328396-p2gvpe8i 66 5 receptors receptor NNS cord-328396-p2gvpe8i 66 6 such such JJ cord-328396-p2gvpe8i 66 7 as as IN cord-328396-p2gvpe8i 66 8 CD209L cd209l NN cord-328396-p2gvpe8i 66 9 and and CC cord-328396-p2gvpe8i 66 10 vimentin vimentin NNS cord-328396-p2gvpe8i 66 11 that that WDT cord-328396-p2gvpe8i 66 12 have have VBP cord-328396-p2gvpe8i 66 13 been be VBN cord-328396-p2gvpe8i 66 14 proposed propose VBN cord-328396-p2gvpe8i 66 15 to to TO cord-328396-p2gvpe8i 66 16 serve serve VB cord-328396-p2gvpe8i 66 17 as as IN cord-328396-p2gvpe8i 66 18 putative putative JJ cord-328396-p2gvpe8i 66 19 receptors receptor NNS cord-328396-p2gvpe8i 66 20 of of IN cord-328396-p2gvpe8i 66 21 SARS SARS NNP cord-328396-p2gvpe8i 66 22 viruses virus NNS cord-328396-p2gvpe8i 66 23 are be VBP cord-328396-p2gvpe8i 66 24 also also RB cord-328396-p2gvpe8i 66 25 expressed express VBN cord-328396-p2gvpe8i 66 26 in in IN cord-328396-p2gvpe8i 66 27 mEC mEC NNP cord-328396-p2gvpe8i 66 28 ( ( -LRB- cord-328396-p2gvpe8i 66 29 Jeffers Jeffers NNP cord-328396-p2gvpe8i 66 30 et et NNP cord-328396-p2gvpe8i 66 31 al al NNP cord-328396-p2gvpe8i 66 32 . . NNP cord-328396-p2gvpe8i 66 33 , , , cord-328396-p2gvpe8i 66 34 2004 2004 CD cord-328396-p2gvpe8i 66 35 ; ; : cord-328396-p2gvpe8i 66 36 Yu Yu NNP cord-328396-p2gvpe8i 66 37 et et NNP cord-328396-p2gvpe8i 66 38 al al NNP cord-328396-p2gvpe8i 66 39 . . NNP cord-328396-p2gvpe8i 66 40 , , , cord-328396-p2gvpe8i 66 41 2016 2016 CD cord-328396-p2gvpe8i 66 42 ) ) -RRB- cord-328396-p2gvpe8i 66 43 . . . cord-328396-p2gvpe8i 67 1 Another another DT cord-328396-p2gvpe8i 67 2 possibility possibility NN cord-328396-p2gvpe8i 67 3 worth worth JJ cord-328396-p2gvpe8i 67 4 mentioning mention VBG cord-328396-p2gvpe8i 67 5 is be VBZ cord-328396-p2gvpe8i 67 6 that that IN cord-328396-p2gvpe8i 67 7 SARS SARS NNP cord-328396-p2gvpe8i 67 8 - - HYPH cord-328396-p2gvpe8i 67 9 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 67 10 may may MD cord-328396-p2gvpe8i 67 11 also also RB cord-328396-p2gvpe8i 67 12 be be VB cord-328396-p2gvpe8i 67 13 transported transport VBN cord-328396-p2gvpe8i 67 14 to to IN cord-328396-p2gvpe8i 67 15 mEC mec NN cord-328396-p2gvpe8i 67 16 via via IN cord-328396-p2gvpe8i 67 17 air air NN cord-328396-p2gvpe8i 67 18 - - HYPH cord-328396-p2gvpe8i 67 19 borne bear VBN cord-328396-p2gvpe8i 67 20 particulate particulate NN cord-328396-p2gvpe8i 67 21 matter matter NN cord-328396-p2gvpe8i 67 22 with with IN cord-328396-p2gvpe8i 67 23 a a DT cord-328396-p2gvpe8i 67 24 diameter diameter NN cord-328396-p2gvpe8i 67 25 of of IN cord-328396-p2gvpe8i 67 26 2.5 2.5 CD cord-328396-p2gvpe8i 67 27 micrometers micrometer NNS cord-328396-p2gvpe8i 67 28 ( ( -LRB- cord-328396-p2gvpe8i 67 29 PM2.5 PM2.5 NNP cord-328396-p2gvpe8i 67 30 ) ) -RRB- cord-328396-p2gvpe8i 67 31 or or CC cord-328396-p2gvpe8i 67 32 smaller small JJR cord-328396-p2gvpe8i 67 33 . . . cord-328396-p2gvpe8i 68 1 These these DT cord-328396-p2gvpe8i 68 2 fine fine JJ cord-328396-p2gvpe8i 68 3 air air NN cord-328396-p2gvpe8i 68 4 particles particle NNS cord-328396-p2gvpe8i 68 5 can can MD cord-328396-p2gvpe8i 68 6 easily easily RB cord-328396-p2gvpe8i 68 7 reach reach VB cord-328396-p2gvpe8i 68 8 the the DT cord-328396-p2gvpe8i 68 9 smallest small JJS cord-328396-p2gvpe8i 68 10 of of IN cord-328396-p2gvpe8i 68 11 the the DT cord-328396-p2gvpe8i 68 12 human human NNP cord-328396-p2gvpe8i 68 13 airways airways NNP cord-328396-p2gvpe8i 68 14 , , , cord-328396-p2gvpe8i 68 15 cross cross VB cord-328396-p2gvpe8i 68 16 the the DT cord-328396-p2gvpe8i 68 17 alveolar alveolar NN cord-328396-p2gvpe8i 68 18 - - HYPH cord-328396-p2gvpe8i 68 19 capillary capillary JJ cord-328396-p2gvpe8i 68 20 barrier barrier NN cord-328396-p2gvpe8i 68 21 , , , cord-328396-p2gvpe8i 68 22 deposit deposit NN cord-328396-p2gvpe8i 68 23 on on IN cord-328396-p2gvpe8i 68 24 vascular vascular JJ cord-328396-p2gvpe8i 68 25 endothelium endothelium NN cord-328396-p2gvpe8i 68 26 via via IN cord-328396-p2gvpe8i 68 27 specific specific JJ cord-328396-p2gvpe8i 68 28 receptors receptor NNS cord-328396-p2gvpe8i 68 29 , , , cord-328396-p2gvpe8i 68 30 modulate modulate VB cord-328396-p2gvpe8i 68 31 vascular vascular JJ cord-328396-p2gvpe8i 68 32 permeability permeability NN cord-328396-p2gvpe8i 68 33 and and CC cord-328396-p2gvpe8i 68 34 facilitate facilitate VB cord-328396-p2gvpe8i 68 35 systemic systemic JJ cord-328396-p2gvpe8i 68 36 inflammation inflammation NN cord-328396-p2gvpe8i 68 37 , , , cord-328396-p2gvpe8i 68 38 also also RB cord-328396-p2gvpe8i 68 39 leading lead VBG cord-328396-p2gvpe8i 68 40 to to IN cord-328396-p2gvpe8i 68 41 coagulation coagulation NN cord-328396-p2gvpe8i 68 42 ( ( -LRB- cord-328396-p2gvpe8i 68 43 Wang Wang NNP cord-328396-p2gvpe8i 68 44 et et NNP cord-328396-p2gvpe8i 68 45 al al NNP cord-328396-p2gvpe8i 68 46 . . NNP cord-328396-p2gvpe8i 68 47 , , , cord-328396-p2gvpe8i 68 48 2017 2017 CD cord-328396-p2gvpe8i 68 49 ) ) -RRB- cord-328396-p2gvpe8i 68 50 . . . cord-328396-p2gvpe8i 69 1 Recent recent JJ cord-328396-p2gvpe8i 69 2 reports report NNS cord-328396-p2gvpe8i 69 3 have have VBP cord-328396-p2gvpe8i 69 4 indeed indeed RB cord-328396-p2gvpe8i 69 5 shown show VBN cord-328396-p2gvpe8i 69 6 a a DT cord-328396-p2gvpe8i 69 7 positive positive JJ cord-328396-p2gvpe8i 69 8 correlation correlation NN cord-328396-p2gvpe8i 69 9 between between IN cord-328396-p2gvpe8i 69 10 the the DT cord-328396-p2gvpe8i 69 11 increased increase VBN cord-328396-p2gvpe8i 69 12 presence presence NN cord-328396-p2gvpe8i 69 13 of of IN cord-328396-p2gvpe8i 69 14 air air NN cord-328396-p2gvpe8i 69 15 pollutants pollutant NNS cord-328396-p2gvpe8i 69 16 ( ( -LRB- cord-328396-p2gvpe8i 69 17 PM2.5 PM2.5 NNP cord-328396-p2gvpe8i 69 18 ) ) -RRB- cord-328396-p2gvpe8i 69 19 and and CC cord-328396-p2gvpe8i 69 20 COVID-19 covid-19 VB cord-328396-p2gvpe8i 69 21 spread spread NN cord-328396-p2gvpe8i 69 22 and and CC cord-328396-p2gvpe8i 69 23 lethality lethality NN cord-328396-p2gvpe8i 69 24 ( ( -LRB- cord-328396-p2gvpe8i 69 25 Fattorini Fattorini NNP cord-328396-p2gvpe8i 69 26 and and CC cord-328396-p2gvpe8i 69 27 Regoli Regoli NNP cord-328396-p2gvpe8i 69 28 , , , cord-328396-p2gvpe8i 69 29 2020 2020 CD cord-328396-p2gvpe8i 69 30 ) ) -RRB- cord-328396-p2gvpe8i 69 31 . . . cord-328396-p2gvpe8i 70 1 Although although IN cord-328396-p2gvpe8i 70 2 the the DT cord-328396-p2gvpe8i 70 3 air air NN cord-328396-p2gvpe8i 70 4 - - HYPH cord-328396-p2gvpe8i 70 5 borne bear VBN cord-328396-p2gvpe8i 70 6 spread spread NN cord-328396-p2gvpe8i 70 7 of of IN cord-328396-p2gvpe8i 70 8 SARS SARS NNP cord-328396-p2gvpe8i 70 9 - - HYPH cord-328396-p2gvpe8i 70 10 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 70 11 via via IN cord-328396-p2gvpe8i 70 12 PM PM NNP cord-328396-p2gvpe8i 70 13 and and CC cord-328396-p2gvpe8i 70 14 its -PRON- PRP$ cord-328396-p2gvpe8i 70 15 direct direct JJ cord-328396-p2gvpe8i 70 16 entry entry NN cord-328396-p2gvpe8i 70 17 into into IN cord-328396-p2gvpe8i 70 18 mEC mEC NNP cord-328396-p2gvpe8i 70 19 remains remain VBZ cord-328396-p2gvpe8i 70 20 to to TO cord-328396-p2gvpe8i 70 21 be be VB cord-328396-p2gvpe8i 70 22 established establish VBN cord-328396-p2gvpe8i 70 23 , , , cord-328396-p2gvpe8i 70 24 it -PRON- PRP cord-328396-p2gvpe8i 70 25 would would MD cord-328396-p2gvpe8i 70 26 be be VB cord-328396-p2gvpe8i 70 27 interesting interesting JJ cord-328396-p2gvpe8i 70 28 to to TO cord-328396-p2gvpe8i 70 29 unravel unravel VB cord-328396-p2gvpe8i 70 30 molecular molecular JJ cord-328396-p2gvpe8i 70 31 mechanisms mechanism NNS cord-328396-p2gvpe8i 70 32 if if IN cord-328396-p2gvpe8i 70 33 and and CC cord-328396-p2gvpe8i 70 34 how how WRB cord-328396-p2gvpe8i 70 35 SARS SARS NNP cord-328396-p2gvpe8i 70 36 - - HYPH cord-328396-p2gvpe8i 70 37 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 70 38 survive survive VBP cord-328396-p2gvpe8i 70 39 and and CC cord-328396-p2gvpe8i 70 40 thrive thrive VBP cord-328396-p2gvpe8i 70 41 in in IN cord-328396-p2gvpe8i 70 42 the the DT cord-328396-p2gvpe8i 70 43 mEC mec NN cord-328396-p2gvpe8i 70 44 . . . cord-328396-p2gvpe8i 71 1 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 71 2 infection infection NN cord-328396-p2gvpe8i 71 3 also also RB cord-328396-p2gvpe8i 71 4 seems seem VBZ cord-328396-p2gvpe8i 71 5 to to TO cord-328396-p2gvpe8i 71 6 mount mount VB cord-328396-p2gvpe8i 71 7 an an DT cord-328396-p2gvpe8i 71 8 attack attack NN cord-328396-p2gvpe8i 71 9 and and CC cord-328396-p2gvpe8i 71 10 exacerbate exacerbate VB cord-328396-p2gvpe8i 71 11 endothelial endothelial JJ cord-328396-p2gvpe8i 71 12 damage damage NN cord-328396-p2gvpe8i 71 13 in in IN cord-328396-p2gvpe8i 71 14 other other JJ cord-328396-p2gvpe8i 71 15 vascular vascular JJ cord-328396-p2gvpe8i 71 16 beds bed NNS cord-328396-p2gvpe8i 72 1 ( ( -LRB- cord-328396-p2gvpe8i 72 2 Sardu Sardu NNP cord-328396-p2gvpe8i 72 3 et et FW cord-328396-p2gvpe8i 72 4 al al NNP cord-328396-p2gvpe8i 72 5 . . NNP cord-328396-p2gvpe8i 72 6 , , , cord-328396-p2gvpe8i 72 7 2020a 2020a CD cord-328396-p2gvpe8i 72 8 ) ) -RRB- cord-328396-p2gvpe8i 72 9 . . . cord-328396-p2gvpe8i 73 1 Active active JJ cord-328396-p2gvpe8i 73 2 SARS SARS NNP cord-328396-p2gvpe8i 73 3 - - HYPH cord-328396-p2gvpe8i 73 4 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 73 5 replication replication NN cord-328396-p2gvpe8i 73 6 in in IN cord-328396-p2gvpe8i 73 7 human human JJ cord-328396-p2gvpe8i 73 8 capillary capillary JJ cord-328396-p2gvpe8i 73 9 organoids organoid NNS cord-328396-p2gvpe8i 74 1 that that WDT cord-328396-p2gvpe8i 74 2 closely closely RB cord-328396-p2gvpe8i 74 3 resemble resemble VB cord-328396-p2gvpe8i 74 4 human human JJ cord-328396-p2gvpe8i 74 5 capillaries capillary NNS cord-328396-p2gvpe8i 74 6 has have VBZ cord-328396-p2gvpe8i 74 7 been be VBN cord-328396-p2gvpe8i 74 8 demonstrated demonstrate VBN cord-328396-p2gvpe8i 74 9 , , , cord-328396-p2gvpe8i 74 10 suggestive suggestive JJ cord-328396-p2gvpe8i 74 11 of of IN cord-328396-p2gvpe8i 74 12 the the DT cord-328396-p2gvpe8i 74 13 fact fact NN cord-328396-p2gvpe8i 74 14 that that IN cord-328396-p2gvpe8i 74 15 the the DT cord-328396-p2gvpe8i 74 16 virus virus NN cord-328396-p2gvpe8i 74 17 could could MD cord-328396-p2gvpe8i 74 18 directly directly RB cord-328396-p2gvpe8i 74 19 infect infect VB cord-328396-p2gvpe8i 74 20 ACE2-positive ace2-positive JJ cord-328396-p2gvpe8i 74 21 blood blood NN cord-328396-p2gvpe8i 74 22 vessel vessel NN cord-328396-p2gvpe8i 74 23 cells cell NNS cord-328396-p2gvpe8i 74 24 ( ( -LRB- cord-328396-p2gvpe8i 74 25 Monteil Monteil NNP cord-328396-p2gvpe8i 74 26 et et NNP cord-328396-p2gvpe8i 74 27 al al NNP cord-328396-p2gvpe8i 74 28 . . NNP cord-328396-p2gvpe8i 74 29 , , , cord-328396-p2gvpe8i 74 30 2020 2020 CD cord-328396-p2gvpe8i 74 31 ) ) -RRB- cord-328396-p2gvpe8i 74 32 . . . cord-328396-p2gvpe8i 75 1 Presence presence NN cord-328396-p2gvpe8i 75 2 of of IN cord-328396-p2gvpe8i 75 3 viral viral JJ cord-328396-p2gvpe8i 75 4 elements element NNS cord-328396-p2gvpe8i 75 5 within within IN cord-328396-p2gvpe8i 75 6 the the DT cord-328396-p2gvpe8i 75 7 endothelial endothelial JJ cord-328396-p2gvpe8i 75 8 cells cell NNS cord-328396-p2gvpe8i 75 9 and and CC cord-328396-p2gvpe8i 75 10 diffuse diffuse VB cord-328396-p2gvpe8i 75 11 endothelial endothelial JJ cord-328396-p2gvpe8i 75 12 inflammation inflammation NN cord-328396-p2gvpe8i 75 13 has have VBZ cord-328396-p2gvpe8i 75 14 been be VBN cord-328396-p2gvpe8i 75 15 documented document VBN cord-328396-p2gvpe8i 75 16 in in IN cord-328396-p2gvpe8i 75 17 post post JJ cord-328396-p2gvpe8i 75 18 - - JJ cord-328396-p2gvpe8i 75 19 mortem mortem JJ cord-328396-p2gvpe8i 75 20 biopsies biopsy NNS cord-328396-p2gvpe8i 75 21 of of IN cord-328396-p2gvpe8i 75 22 lung lung NN cord-328396-p2gvpe8i 75 23 , , , cord-328396-p2gvpe8i 75 24 heart heart NN cord-328396-p2gvpe8i 75 25 , , , cord-328396-p2gvpe8i 75 26 kidney kidney NN cord-328396-p2gvpe8i 75 27 , , , cord-328396-p2gvpe8i 75 28 skin skin NN cord-328396-p2gvpe8i 75 29 and and CC cord-328396-p2gvpe8i 75 30 liver liver NN cord-328396-p2gvpe8i 75 31 ( ( -LRB- cord-328396-p2gvpe8i 75 32 Colmenero Colmenero NNP cord-328396-p2gvpe8i 75 33 et et NNP cord-328396-p2gvpe8i 75 34 al al NNP cord-328396-p2gvpe8i 75 35 . . NNP cord-328396-p2gvpe8i 75 36 , , , cord-328396-p2gvpe8i 75 37 2020 2020 CD cord-328396-p2gvpe8i 75 38 ; ; : cord-328396-p2gvpe8i 75 39 Varga Varga NNP cord-328396-p2gvpe8i 75 40 et et NNP cord-328396-p2gvpe8i 75 41 al al NNP cord-328396-p2gvpe8i 75 42 . . NNP cord-328396-p2gvpe8i 75 43 , , , cord-328396-p2gvpe8i 75 44 2020 2020 CD cord-328396-p2gvpe8i 75 45 ) ) -RRB- cord-328396-p2gvpe8i 75 46 . . . cord-328396-p2gvpe8i 76 1 These these DT cord-328396-p2gvpe8i 76 2 studies study NNS cord-328396-p2gvpe8i 76 3 suggest suggest VBP cord-328396-p2gvpe8i 76 4 that that IN cord-328396-p2gvpe8i 76 5 a a DT cord-328396-p2gvpe8i 76 6 direct direct JJ cord-328396-p2gvpe8i 76 7 SARS SARS NNP cord-328396-p2gvpe8i 76 8 - - HYPH cord-328396-p2gvpe8i 76 9 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 76 10 infection infection NN cord-328396-p2gvpe8i 76 11 facilitates facilitate VBZ cord-328396-p2gvpe8i 76 12 endothelial endothelial JJ cord-328396-p2gvpe8i 76 13 injury injury NN cord-328396-p2gvpe8i 76 14 in in IN cord-328396-p2gvpe8i 76 15 other other JJ cord-328396-p2gvpe8i 76 16 vascular vascular JJ cord-328396-p2gvpe8i 76 17 beds bed NNS cord-328396-p2gvpe8i 76 18 besides besides IN cord-328396-p2gvpe8i 76 19 the the DT cord-328396-p2gvpe8i 76 20 lungs lung NNS cord-328396-p2gvpe8i 76 21 . . . cord-328396-p2gvpe8i 77 1 However however RB cord-328396-p2gvpe8i 77 2 , , , cord-328396-p2gvpe8i 77 3 since since IN cord-328396-p2gvpe8i 77 4 these these DT cord-328396-p2gvpe8i 77 5 are be VBP cord-328396-p2gvpe8i 77 6 post post JJ cord-328396-p2gvpe8i 77 7 - - JJ cord-328396-p2gvpe8i 77 8 mortem mortem JJ cord-328396-p2gvpe8i 77 9 biopsies biopsy NNS cord-328396-p2gvpe8i 77 10 of of IN cord-328396-p2gvpe8i 77 11 patients patient NNS cord-328396-p2gvpe8i 77 12 with with IN cord-328396-p2gvpe8i 77 13 respiratory respiratory JJ cord-328396-p2gvpe8i 77 14 failure failure NN cord-328396-p2gvpe8i 77 15 , , , cord-328396-p2gvpe8i 77 16 it -PRON- PRP cord-328396-p2gvpe8i 77 17 is be VBZ cord-328396-p2gvpe8i 77 18 probable probable JJ cord-328396-p2gvpe8i 77 19 that that IN cord-328396-p2gvpe8i 77 20 endothelial endothelial JJ cord-328396-p2gvpe8i 77 21 damage damage NN cord-328396-p2gvpe8i 77 22 at at IN cord-328396-p2gvpe8i 77 23 this this DT cord-328396-p2gvpe8i 77 24 phase phase NN cord-328396-p2gvpe8i 77 25 is be VBZ cord-328396-p2gvpe8i 77 26 because because IN cord-328396-p2gvpe8i 77 27 of of IN cord-328396-p2gvpe8i 77 28 an an DT cord-328396-p2gvpe8i 77 29 overwhelmed overwhelmed JJ cord-328396-p2gvpe8i 77 30 host host NN cord-328396-p2gvpe8i 77 31 inflammatory inflammatory JJ cord-328396-p2gvpe8i 77 32 response response NN cord-328396-p2gvpe8i 77 33 , , , cord-328396-p2gvpe8i 77 34 rather rather RB cord-328396-p2gvpe8i 77 35 than than IN cord-328396-p2gvpe8i 77 36 viral viral JJ cord-328396-p2gvpe8i 77 37 replication replication NN cord-328396-p2gvpe8i 77 38 and and CC cord-328396-p2gvpe8i 77 39 increased increase VBN cord-328396-p2gvpe8i 77 40 viral viral JJ cord-328396-p2gvpe8i 77 41 loads load NNS cord-328396-p2gvpe8i 77 42 in in IN cord-328396-p2gvpe8i 77 43 the the DT cord-328396-p2gvpe8i 77 44 endothelial endothelial JJ cord-328396-p2gvpe8i 77 45 cells cell NNS cord-328396-p2gvpe8i 77 46 . . . cord-328396-p2gvpe8i 78 1 A a DT cord-328396-p2gvpe8i 78 2 high high JJ cord-328396-p2gvpe8i 78 3 mortality mortality NN cord-328396-p2gvpe8i 78 4 rate rate NN cord-328396-p2gvpe8i 78 5 and and CC cord-328396-p2gvpe8i 78 6 poor poor JJ cord-328396-p2gvpe8i 78 7 clinical clinical JJ cord-328396-p2gvpe8i 78 8 outcomes outcome NNS cord-328396-p2gvpe8i 78 9 due due JJ cord-328396-p2gvpe8i 78 10 to to IN cord-328396-p2gvpe8i 78 11 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 78 12 infections infection NNS cord-328396-p2gvpe8i 78 13 in in IN cord-328396-p2gvpe8i 78 14 aged aged JJ cord-328396-p2gvpe8i 78 15 subjects subject NNS cord-328396-p2gvpe8i 78 16 and and CC cord-328396-p2gvpe8i 78 17 patients patient NNS cord-328396-p2gvpe8i 78 18 with with IN cord-328396-p2gvpe8i 78 19 comorbid comorbid NN cord-328396-p2gvpe8i 78 20 conditions condition NNS cord-328396-p2gvpe8i 78 21 including include VBG cord-328396-p2gvpe8i 78 22 diabetes diabetes NN cord-328396-p2gvpe8i 78 23 , , , cord-328396-p2gvpe8i 78 24 obesity obesity NN cord-328396-p2gvpe8i 78 25 and and CC cord-328396-p2gvpe8i 78 26 hypertension hypertension NN cord-328396-p2gvpe8i 78 27 may may MD cord-328396-p2gvpe8i 78 28 also also RB cord-328396-p2gvpe8i 78 29 be be VB cord-328396-p2gvpe8i 78 30 because because IN cord-328396-p2gvpe8i 78 31 of of IN cord-328396-p2gvpe8i 78 32 an an DT cord-328396-p2gvpe8i 78 33 underlying underlying JJ cord-328396-p2gvpe8i 78 34 endothelial endothelial JJ cord-328396-p2gvpe8i 78 35 dysfunction dysfunction NN cord-328396-p2gvpe8i 78 36 . . . cord-328396-p2gvpe8i 79 1 Indeed indeed RB cord-328396-p2gvpe8i 79 2 , , , cord-328396-p2gvpe8i 79 3 certain certain JJ cord-328396-p2gvpe8i 79 4 features feature NNS cord-328396-p2gvpe8i 79 5 of of IN cord-328396-p2gvpe8i 79 6 endothelial endothelial JJ cord-328396-p2gvpe8i 79 7 dysfunction dysfunction NN cord-328396-p2gvpe8i 79 8 such such JJ cord-328396-p2gvpe8i 79 9 as as IN cord-328396-p2gvpe8i 79 10 altered alter VBN cord-328396-p2gvpe8i 79 11 permeability permeability NN cord-328396-p2gvpe8i 79 12 , , , cord-328396-p2gvpe8i 79 13 imbalance imbalance NN cord-328396-p2gvpe8i 79 14 between between IN cord-328396-p2gvpe8i 79 15 vasoconstrictors vasoconstrictor NNS cord-328396-p2gvpe8i 79 16 and and CC cord-328396-p2gvpe8i 79 17 vasodilators vasodilator NNS cord-328396-p2gvpe8i 79 18 , , , cord-328396-p2gvpe8i 79 19 markers marker NNS cord-328396-p2gvpe8i 79 20 of of IN cord-328396-p2gvpe8i 79 21 procoagulation procoagulation NN cord-328396-p2gvpe8i 79 22 that that WDT cord-328396-p2gvpe8i 79 23 are be VBP cord-328396-p2gvpe8i 79 24 well well RB cord-328396-p2gvpe8i 79 25 known know VBN cord-328396-p2gvpe8i 79 26 to to TO cord-328396-p2gvpe8i 79 27 be be VB cord-328396-p2gvpe8i 79 28 present present JJ cord-328396-p2gvpe8i 79 29 in in IN cord-328396-p2gvpe8i 79 30 all all PDT cord-328396-p2gvpe8i 79 31 the the DT cord-328396-p2gvpe8i 79 32 above above JJ cord-328396-p2gvpe8i 79 33 conditions condition NNS cord-328396-p2gvpe8i 79 34 , , , cord-328396-p2gvpe8i 79 35 would would MD cord-328396-p2gvpe8i 79 36 serve serve VB cord-328396-p2gvpe8i 79 37 as as IN cord-328396-p2gvpe8i 79 38 key key JJ cord-328396-p2gvpe8i 79 39 indicators indicator NNS cord-328396-p2gvpe8i 79 40 for for IN cord-328396-p2gvpe8i 79 41 identifying identify VBG cord-328396-p2gvpe8i 79 42 those those DT cord-328396-p2gvpe8i 79 43 subjects subject NNS cord-328396-p2gvpe8i 79 44 who who WP cord-328396-p2gvpe8i 79 45 are be VBP cord-328396-p2gvpe8i 79 46 at at IN cord-328396-p2gvpe8i 79 47 a a DT cord-328396-p2gvpe8i 79 48 higher high JJR cord-328396-p2gvpe8i 79 49 risk risk NN cord-328396-p2gvpe8i 79 50 of of IN cord-328396-p2gvpe8i 79 51 developing develop VBG cord-328396-p2gvpe8i 79 52 severe severe JJ cord-328396-p2gvpe8i 79 53 form form NN cord-328396-p2gvpe8i 79 54 of of IN cord-328396-p2gvpe8i 79 55 the the DT cord-328396-p2gvpe8i 79 56 disease disease NN cord-328396-p2gvpe8i 79 57 . . . cord-328396-p2gvpe8i 80 1 Large large JJ cord-328396-p2gvpe8i 80 2 - - HYPH cord-328396-p2gvpe8i 80 3 vessel vessel NN cord-328396-p2gvpe8i 80 4 stroke stroke NN cord-328396-p2gvpe8i 80 5 has have VBZ cord-328396-p2gvpe8i 80 6 been be VBN cord-328396-p2gvpe8i 80 7 described describe VBN cord-328396-p2gvpe8i 80 8 in in IN cord-328396-p2gvpe8i 80 9 young young JJ cord-328396-p2gvpe8i 80 10 patients patient NNS cord-328396-p2gvpe8i 80 11 of of IN cord-328396-p2gvpe8i 80 12 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 80 13 with with IN cord-328396-p2gvpe8i 80 14 a a DT cord-328396-p2gvpe8i 80 15 mean mean JJ cord-328396-p2gvpe8i 80 16 stroke stroke NN cord-328396-p2gvpe8i 80 17 scale scale NN cord-328396-p2gvpe8i 80 18 of of IN cord-328396-p2gvpe8i 80 19 17 17 CD cord-328396-p2gvpe8i 80 20 indicating indicate VBG cord-328396-p2gvpe8i 80 21 a a DT cord-328396-p2gvpe8i 80 22 large large JJ cord-328396-p2gvpe8i 80 23 area area NN cord-328396-p2gvpe8i 80 24 of of IN cord-328396-p2gvpe8i 80 25 ischemia ischemia NN cord-328396-p2gvpe8i 80 26 . . . cord-328396-p2gvpe8i 81 1 All all DT cord-328396-p2gvpe8i 81 2 of of IN cord-328396-p2gvpe8i 81 3 them -PRON- PRP cord-328396-p2gvpe8i 81 4 had have VBD cord-328396-p2gvpe8i 81 5 to to TO cord-328396-p2gvpe8i 81 6 be be VB cord-328396-p2gvpe8i 81 7 given give VBN cord-328396-p2gvpe8i 81 8 clot clot NN cord-328396-p2gvpe8i 81 9 retrieval retrieval NN cord-328396-p2gvpe8i 81 10 therapy therapy NN cord-328396-p2gvpe8i 81 11 , , , cord-328396-p2gvpe8i 81 12 anticoagulation anticoagulation NN cord-328396-p2gvpe8i 81 13 and and CC cord-328396-p2gvpe8i 81 14 antiplatelets antiplatelet NNS cord-328396-p2gvpe8i 81 15 ( ( -LRB- cord-328396-p2gvpe8i 81 16 Oxley Oxley NNP cord-328396-p2gvpe8i 81 17 et et NNP cord-328396-p2gvpe8i 81 18 al al NNP cord-328396-p2gvpe8i 81 19 . . NNP cord-328396-p2gvpe8i 81 20 , , , cord-328396-p2gvpe8i 81 21 2020 2020 CD cord-328396-p2gvpe8i 81 22 ) ) -RRB- cord-328396-p2gvpe8i 81 23 . . . cord-328396-p2gvpe8i 82 1 Three three CD cord-328396-p2gvpe8i 82 2 patients patient NNS cord-328396-p2gvpe8i 82 3 in in IN cord-328396-p2gvpe8i 82 4 this this DT cord-328396-p2gvpe8i 82 5 study study NN cord-328396-p2gvpe8i 82 6 had have VBD cord-328396-p2gvpe8i 82 7 diabetes diabetes NN cord-328396-p2gvpe8i 82 8 indicating indicate VBG cord-328396-p2gvpe8i 82 9 that that IN cord-328396-p2gvpe8i 82 10 an an DT cord-328396-p2gvpe8i 82 11 underlying underlying JJ cord-328396-p2gvpe8i 82 12 endothelial endothelial JJ cord-328396-p2gvpe8i 82 13 damage damage NN cord-328396-p2gvpe8i 82 14 might may MD cord-328396-p2gvpe8i 82 15 be be VB cord-328396-p2gvpe8i 82 16 one one CD cord-328396-p2gvpe8i 82 17 of of IN cord-328396-p2gvpe8i 82 18 the the DT cord-328396-p2gvpe8i 82 19 key key JJ cord-328396-p2gvpe8i 82 20 reasons reason NNS cord-328396-p2gvpe8i 82 21 of of IN cord-328396-p2gvpe8i 82 22 SARS SARS NNP cord-328396-p2gvpe8i 82 23 - - HYPH cord-328396-p2gvpe8i 82 24 CoV-2-induced cov-2-induce VBN cord-328396-p2gvpe8i 82 25 stroke stroke NN cord-328396-p2gvpe8i 82 26 in in IN cord-328396-p2gvpe8i 82 27 these these DT cord-328396-p2gvpe8i 82 28 patients patient NNS cord-328396-p2gvpe8i 82 29 . . . cord-328396-p2gvpe8i 83 1 Stroke stroke NN cord-328396-p2gvpe8i 83 2 and and CC cord-328396-p2gvpe8i 83 3 thrombotic thrombotic JJ cord-328396-p2gvpe8i 83 4 events event NNS cord-328396-p2gvpe8i 83 5 in in IN cord-328396-p2gvpe8i 83 6 brain brain NN cord-328396-p2gvpe8i 83 7 could could MD cord-328396-p2gvpe8i 83 8 also also RB cord-328396-p2gvpe8i 83 9 be be VB cord-328396-p2gvpe8i 83 10 , , , cord-328396-p2gvpe8i 83 11 however however RB cord-328396-p2gvpe8i 83 12 , , , cord-328396-p2gvpe8i 83 13 ascribed ascribe VBN cord-328396-p2gvpe8i 83 14 to to IN cord-328396-p2gvpe8i 83 15 viral viral JJ cord-328396-p2gvpe8i 83 16 infection infection NN cord-328396-p2gvpe8i 83 17 - - HYPH cord-328396-p2gvpe8i 83 18 induced induce VBN cord-328396-p2gvpe8i 83 19 thrombophilia thrombophilia NNP cord-328396-p2gvpe8i 83 20 . . . cord-328396-p2gvpe8i 84 1 The the DT cord-328396-p2gvpe8i 84 2 nucleocapsid nucleocapsid NN cord-328396-p2gvpe8i 84 3 and and CC cord-328396-p2gvpe8i 84 4 spike spike NN cord-328396-p2gvpe8i 84 5 proteins protein NNS cord-328396-p2gvpe8i 84 6 of of IN cord-328396-p2gvpe8i 84 7 the the DT cord-328396-p2gvpe8i 84 8 SARS SARS NNP cord-328396-p2gvpe8i 84 9 - - HYPH cord-328396-p2gvpe8i 84 10 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 84 11 have have VBP cord-328396-p2gvpe8i 84 12 been be VBN cord-328396-p2gvpe8i 84 13 speculated speculate VBN cord-328396-p2gvpe8i 84 14 to to TO cord-328396-p2gvpe8i 84 15 contribute contribute VB cord-328396-p2gvpe8i 84 16 to to IN cord-328396-p2gvpe8i 84 17 a a DT cord-328396-p2gvpe8i 84 18 pro pro JJ cord-328396-p2gvpe8i 84 19 - - JJ cord-328396-p2gvpe8i 84 20 thrombotic thrombotic JJ cord-328396-p2gvpe8i 84 21 state state NN cord-328396-p2gvpe8i 84 22 due due IN cord-328396-p2gvpe8i 84 23 to to IN cord-328396-p2gvpe8i 84 24 their -PRON- PRP$ cord-328396-p2gvpe8i 84 25 modulation modulation NN cord-328396-p2gvpe8i 84 26 of of IN cord-328396-p2gvpe8i 84 27 clotting clot VBG cord-328396-p2gvpe8i 84 28 pathways pathway NNS cord-328396-p2gvpe8i 84 29 in in IN cord-328396-p2gvpe8i 84 30 the the DT cord-328396-p2gvpe8i 84 31 lungs lung NNS cord-328396-p2gvpe8i 84 32 via via IN cord-328396-p2gvpe8i 84 33 dysregulation dysregulation NN cord-328396-p2gvpe8i 84 34 of of IN cord-328396-p2gvpe8i 84 35 ACE2 ACE2 NNP cord-328396-p2gvpe8i 85 1 ( ( -LRB- cord-328396-p2gvpe8i 85 2 McGonagle McGonagle NNP cord-328396-p2gvpe8i 85 3 et et NNP cord-328396-p2gvpe8i 85 4 al al NNP cord-328396-p2gvpe8i 85 5 . . NNP cord-328396-p2gvpe8i 85 6 , , , cord-328396-p2gvpe8i 85 7 2020 2020 CD cord-328396-p2gvpe8i 85 8 ) ) -RRB- cord-328396-p2gvpe8i 85 9 . . . cord-328396-p2gvpe8i 86 1 The the DT cord-328396-p2gvpe8i 86 2 organotropism organotropism NN cord-328396-p2gvpe8i 86 3 of of IN cord-328396-p2gvpe8i 86 4 SARS SARS NNP cord-328396-p2gvpe8i 86 5 - - : cord-328396-p2gvpe8i 86 6 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 86 7 beyond beyond IN cord-328396-p2gvpe8i 86 8 the the DT cord-328396-p2gvpe8i 86 9 respiratory respiratory JJ cord-328396-p2gvpe8i 86 10 tract tract NN cord-328396-p2gvpe8i 86 11 has have VBZ cord-328396-p2gvpe8i 86 12 been be VBN cord-328396-p2gvpe8i 86 13 seen see VBN cord-328396-p2gvpe8i 86 14 in in IN cord-328396-p2gvpe8i 86 15 autopsy autopsy JJ cord-328396-p2gvpe8i 86 16 studies study NNS cord-328396-p2gvpe8i 86 17 . . . cord-328396-p2gvpe8i 87 1 Besides besides IN cord-328396-p2gvpe8i 87 2 lungs lung NNS cord-328396-p2gvpe8i 87 3 , , , cord-328396-p2gvpe8i 87 4 viral viral JJ cord-328396-p2gvpe8i 87 5 loads load NNS cord-328396-p2gvpe8i 87 6 and and CC cord-328396-p2gvpe8i 87 7 extensive extensive JJ cord-328396-p2gvpe8i 87 8 inflammation inflammation NN cord-328396-p2gvpe8i 87 9 have have VBP cord-328396-p2gvpe8i 87 10 been be VBN cord-328396-p2gvpe8i 87 11 spotted spot VBN cord-328396-p2gvpe8i 87 12 in in IN cord-328396-p2gvpe8i 87 13 the the DT cord-328396-p2gvpe8i 87 14 kidneys kidney NNS cord-328396-p2gvpe8i 87 15 , , , cord-328396-p2gvpe8i 87 16 liver liver NN cord-328396-p2gvpe8i 87 17 , , , cord-328396-p2gvpe8i 87 18 heart heart NN cord-328396-p2gvpe8i 87 19 and and CC cord-328396-p2gvpe8i 87 20 brain brain NN cord-328396-p2gvpe8i 87 21 implicating implicate VBG cord-328396-p2gvpe8i 87 22 direct direct JJ cord-328396-p2gvpe8i 87 23 viral viral JJ cord-328396-p2gvpe8i 87 24 tissue tissue NN cord-328396-p2gvpe8i 87 25 damage damage NN cord-328396-p2gvpe8i 87 26 ( ( -LRB- cord-328396-p2gvpe8i 87 27 Puelles Puelles NNP cord-328396-p2gvpe8i 87 28 et et FW cord-328396-p2gvpe8i 87 29 al al NNP cord-328396-p2gvpe8i 87 30 . . NNP cord-328396-p2gvpe8i 87 31 , , , cord-328396-p2gvpe8i 87 32 2020 2020 CD cord-328396-p2gvpe8i 87 33 ) ) -RRB- cord-328396-p2gvpe8i 87 34 . . . cord-328396-p2gvpe8i 88 1 Given give VBN cord-328396-p2gvpe8i 88 2 the the DT cord-328396-p2gvpe8i 88 3 dissemination dissemination NN cord-328396-p2gvpe8i 88 4 of of IN cord-328396-p2gvpe8i 88 5 the the DT cord-328396-p2gvpe8i 88 6 virus virus NN cord-328396-p2gvpe8i 88 7 to to IN cord-328396-p2gvpe8i 88 8 other other JJ cord-328396-p2gvpe8i 88 9 organs organ NNS cord-328396-p2gvpe8i 88 10 and and CC cord-328396-p2gvpe8i 88 11 presence presence NN cord-328396-p2gvpe8i 88 12 of of IN cord-328396-p2gvpe8i 88 13 MODS mods NN cord-328396-p2gvpe8i 88 14 in in IN cord-328396-p2gvpe8i 88 15 some some DT cord-328396-p2gvpe8i 88 16 patients patient NNS cord-328396-p2gvpe8i 88 17 , , , cord-328396-p2gvpe8i 88 18 Li Li NNP cord-328396-p2gvpe8i 88 19 et et NNP cord-328396-p2gvpe8i 88 20 al al NNP cord-328396-p2gvpe8i 88 21 . . . cord-328396-p2gvpe8i 89 1 ( ( -LRB- cord-328396-p2gvpe8i 89 2 2020 2020 CD cord-328396-p2gvpe8i 89 3 ) ) -RRB- cord-328396-p2gvpe8i 89 4 has have VBZ cord-328396-p2gvpe8i 89 5 conceived conceive VBN cord-328396-p2gvpe8i 89 6 the the DT cord-328396-p2gvpe8i 89 7 term term NN cord-328396-p2gvpe8i 89 8 " " `` cord-328396-p2gvpe8i 89 9 viral viral JJ cord-328396-p2gvpe8i 89 10 sepsis sepsis NN cord-328396-p2gvpe8i 89 11 " " '' cord-328396-p2gvpe8i 89 12 for for IN cord-328396-p2gvpe8i 89 13 severe severe JJ cord-328396-p2gvpe8i 89 14 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 89 15 infections infection NNS cord-328396-p2gvpe8i 89 16 . . . cord-328396-p2gvpe8i 90 1 Although although IN cord-328396-p2gvpe8i 90 2 systemic systemic JJ cord-328396-p2gvpe8i 90 3 inflammation inflammation NN cord-328396-p2gvpe8i 90 4 may may MD cord-328396-p2gvpe8i 90 5 also also RB cord-328396-p2gvpe8i 90 6 occur occur VB cord-328396-p2gvpe8i 90 7 in in IN cord-328396-p2gvpe8i 90 8 the the DT cord-328396-p2gvpe8i 90 9 wake wake NN cord-328396-p2gvpe8i 90 10 of of IN cord-328396-p2gvpe8i 90 11 an an DT cord-328396-p2gvpe8i 90 12 exuberant exuberant JJ cord-328396-p2gvpe8i 90 13 host host NN cord-328396-p2gvpe8i 90 14 cytokine cytokine NN cord-328396-p2gvpe8i 90 15 response response NN cord-328396-p2gvpe8i 90 16 , , , cord-328396-p2gvpe8i 90 17 given give VBN cord-328396-p2gvpe8i 90 18 the the DT cord-328396-p2gvpe8i 90 19 presence presence NN cord-328396-p2gvpe8i 90 20 of of IN cord-328396-p2gvpe8i 90 21 viral viral JJ cord-328396-p2gvpe8i 90 22 elements element NNS cord-328396-p2gvpe8i 90 23 in in IN cord-328396-p2gvpe8i 90 24 extrapulmonary extrapulmonary JJ cord-328396-p2gvpe8i 90 25 tissues tissue NNS cord-328396-p2gvpe8i 90 26 , , , cord-328396-p2gvpe8i 90 27 it -PRON- PRP cord-328396-p2gvpe8i 90 28 is be VBZ cord-328396-p2gvpe8i 90 29 reasonable reasonable JJ cord-328396-p2gvpe8i 90 30 to to TO cord-328396-p2gvpe8i 90 31 hypothesize hypothesize VB cord-328396-p2gvpe8i 90 32 that that IN cord-328396-p2gvpe8i 90 33 SARS SARS NNP cord-328396-p2gvpe8i 90 34 - - HYPH cord-328396-p2gvpe8i 90 35 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 90 36 infection infection NN cord-328396-p2gvpe8i 90 37 might may MD cord-328396-p2gvpe8i 90 38 be be VB cord-328396-p2gvpe8i 90 39 spreading spread VBG cord-328396-p2gvpe8i 90 40 through through IN cord-328396-p2gvpe8i 90 41 the the DT cord-328396-p2gvpe8i 90 42 blood blood NN cord-328396-p2gvpe8i 90 43 cells cell NNS cord-328396-p2gvpe8i 90 44 and and CC cord-328396-p2gvpe8i 90 45 the the DT cord-328396-p2gvpe8i 90 46 endothelial endothelial JJ cord-328396-p2gvpe8i 90 47 route route NN cord-328396-p2gvpe8i 90 48 may may MD cord-328396-p2gvpe8i 90 49 be be VB cord-328396-p2gvpe8i 90 50 one one CD cord-328396-p2gvpe8i 90 51 important important JJ cord-328396-p2gvpe8i 90 52 factor factor NN cord-328396-p2gvpe8i 90 53 facilitating facilitate VBG cord-328396-p2gvpe8i 90 54 this this DT cord-328396-p2gvpe8i 90 55 viral viral JJ cord-328396-p2gvpe8i 90 56 spread spread NN cord-328396-p2gvpe8i 90 57 via via IN cord-328396-p2gvpe8i 90 58 blood blood NN cord-328396-p2gvpe8i 90 59 . . . cord-328396-p2gvpe8i 91 1 However however RB cord-328396-p2gvpe8i 91 2 , , , cord-328396-p2gvpe8i 91 3 this this DT cord-328396-p2gvpe8i 91 4 hypothesis hypothesis NN cord-328396-p2gvpe8i 91 5 needs need VBZ cord-328396-p2gvpe8i 91 6 further further JJ cord-328396-p2gvpe8i 91 7 investigations investigation NNS cord-328396-p2gvpe8i 91 8 as as IN cord-328396-p2gvpe8i 91 9 studies study NNS cord-328396-p2gvpe8i 91 10 have have VBP cord-328396-p2gvpe8i 91 11 reported report VBN cord-328396-p2gvpe8i 91 12 less less JJR cord-328396-p2gvpe8i 91 13 or or CC cord-328396-p2gvpe8i 91 14 even even RB cord-328396-p2gvpe8i 91 15 negligible negligible JJ cord-328396-p2gvpe8i 91 16 amount amount NN cord-328396-p2gvpe8i 91 17 of of IN cord-328396-p2gvpe8i 91 18 viral viral JJ cord-328396-p2gvpe8i 91 19 RNAemia rnaemia NN cord-328396-p2gvpe8i 91 20 in in IN cord-328396-p2gvpe8i 91 21 infected infected JJ cord-328396-p2gvpe8i 91 22 patients patient NNS cord-328396-p2gvpe8i 91 23 Wölfel Wölfel NNP cord-328396-p2gvpe8i 91 24 et et NNP cord-328396-p2gvpe8i 91 25 al al NNP cord-328396-p2gvpe8i 91 26 . . NNP cord-328396-p2gvpe8i 91 27 , , , cord-328396-p2gvpe8i 91 28 2020 2020 CD cord-328396-p2gvpe8i 91 29 ) ) -RRB- cord-328396-p2gvpe8i 91 30 . . . cord-328396-p2gvpe8i 92 1 More more RBR cord-328396-p2gvpe8i 92 2 advanced advanced JJ cord-328396-p2gvpe8i 92 3 and and CC cord-328396-p2gvpe8i 92 4 sensitive sensitive JJ cord-328396-p2gvpe8i 92 5 diagnostic diagnostic JJ cord-328396-p2gvpe8i 92 6 techniques technique NNS cord-328396-p2gvpe8i 92 7 and and CC cord-328396-p2gvpe8i 92 8 the the DT cord-328396-p2gvpe8i 92 9 culture culture NN cord-328396-p2gvpe8i 92 10 of of IN cord-328396-p2gvpe8i 92 11 SARS SARS NNP cord-328396-p2gvpe8i 92 12 - - HYPH cord-328396-p2gvpe8i 92 13 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 92 14 in in IN cord-328396-p2gvpe8i 92 15 blood blood NN cord-328396-p2gvpe8i 92 16 cells cell NNS cord-328396-p2gvpe8i 92 17 would would MD cord-328396-p2gvpe8i 92 18 be be VB cord-328396-p2gvpe8i 92 19 needed need VBN cord-328396-p2gvpe8i 92 20 to to TO cord-328396-p2gvpe8i 92 21 confirm confirm VB cord-328396-p2gvpe8i 92 22 the the DT cord-328396-p2gvpe8i 92 23 hematogenous hematogenous NNP cord-328396-p2gvpe8i 92 24 spread spread NN cord-328396-p2gvpe8i 92 25 of of IN cord-328396-p2gvpe8i 92 26 viral viral JJ cord-328396-p2gvpe8i 92 27 infection infection NN cord-328396-p2gvpe8i 92 28 . . . cord-328396-p2gvpe8i 93 1 Here here RB cord-328396-p2gvpe8i 93 2 , , , cord-328396-p2gvpe8i 93 3 it -PRON- PRP cord-328396-p2gvpe8i 93 4 is be VBZ cord-328396-p2gvpe8i 93 5 also also RB cord-328396-p2gvpe8i 93 6 to to TO cord-328396-p2gvpe8i 93 7 be be VB cord-328396-p2gvpe8i 93 8 noted note VBN cord-328396-p2gvpe8i 93 9 that that IN cord-328396-p2gvpe8i 93 10 most most JJS cord-328396-p2gvpe8i 93 11 of of IN cord-328396-p2gvpe8i 93 12 the the DT cord-328396-p2gvpe8i 93 13 severe severe JJ cord-328396-p2gvpe8i 93 14 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 93 15 patients patient NNS cord-328396-p2gvpe8i 93 16 with with IN cord-328396-p2gvpe8i 93 17 ARDS ARDS NNP cord-328396-p2gvpe8i 93 18 develop develop VB cord-328396-p2gvpe8i 93 19 bacterial bacterial JJ cord-328396-p2gvpe8i 93 20 coinfections coinfection NNS cord-328396-p2gvpe8i 93 21 in in IN cord-328396-p2gvpe8i 93 22 the the DT cord-328396-p2gvpe8i 93 23 hospitals hospital NNS cord-328396-p2gvpe8i 93 24 , , , cord-328396-p2gvpe8i 93 25 thus thus RB cord-328396-p2gvpe8i 93 26 complicating complicate VBG cord-328396-p2gvpe8i 93 27 the the DT cord-328396-p2gvpe8i 93 28 true true JJ cord-328396-p2gvpe8i 93 29 clinical clinical JJ cord-328396-p2gvpe8i 93 30 picture picture NN cord-328396-p2gvpe8i 94 1 ( ( -LRB- cord-328396-p2gvpe8i 94 2 Zhou Zhou NNP cord-328396-p2gvpe8i 94 3 et et NNP cord-328396-p2gvpe8i 94 4 al al NNP cord-328396-p2gvpe8i 94 5 . . NNP cord-328396-p2gvpe8i 94 6 , , , cord-328396-p2gvpe8i 94 7 2020 2020 CD cord-328396-p2gvpe8i 94 8 ) ) -RRB- cord-328396-p2gvpe8i 94 9 . . . cord-328396-p2gvpe8i 95 1 It -PRON- PRP cord-328396-p2gvpe8i 95 2 is be VBZ cord-328396-p2gvpe8i 95 3 thus thus RB cord-328396-p2gvpe8i 95 4 pertinent pertinent JJ cord-328396-p2gvpe8i 95 5 to to TO cord-328396-p2gvpe8i 95 6 clearly clearly RB cord-328396-p2gvpe8i 95 7 distinguish distinguish VB cord-328396-p2gvpe8i 95 8 patients patient NNS cord-328396-p2gvpe8i 95 9 with with IN cord-328396-p2gvpe8i 95 10 only only JJ cord-328396-p2gvpe8i 95 11 SARS SARS NNP cord-328396-p2gvpe8i 95 12 - - HYPH cord-328396-p2gvpe8i 95 13 CoV2 cov2 NN cord-328396-p2gvpe8i 95 14 infections infection NNS cord-328396-p2gvpe8i 95 15 from from IN cord-328396-p2gvpe8i 95 16 those those DT cord-328396-p2gvpe8i 95 17 having have VBG cord-328396-p2gvpe8i 95 18 SARS SARS NNP cord-328396-p2gvpe8i 95 19 - - HYPH cord-328396-p2gvpe8i 95 20 CoV2 CoV2 NNS cord-328396-p2gvpe8i 95 21 plus plus CC cord-328396-p2gvpe8i 95 22 secondary secondary JJ cord-328396-p2gvpe8i 95 23 bacterial bacterial JJ cord-328396-p2gvpe8i 95 24 infections infection NNS cord-328396-p2gvpe8i 95 25 . . . cord-328396-p2gvpe8i 96 1 A a DT cord-328396-p2gvpe8i 96 2 distinguishing distinguishing JJ cord-328396-p2gvpe8i 96 3 marker marker NN cord-328396-p2gvpe8i 96 4 could could MD cord-328396-p2gvpe8i 96 5 be be VB cord-328396-p2gvpe8i 96 6 serum serum NN cord-328396-p2gvpe8i 96 7 procalcitonin procalcitonin NNS cord-328396-p2gvpe8i 96 8 ( ( -LRB- cord-328396-p2gvpe8i 96 9 PCT PCT NNP cord-328396-p2gvpe8i 96 10 ) ) -RRB- cord-328396-p2gvpe8i 96 11 levels level NNS cord-328396-p2gvpe8i 96 12 . . . cord-328396-p2gvpe8i 97 1 Unlike unlike IN cord-328396-p2gvpe8i 97 2 patients patient NNS cord-328396-p2gvpe8i 97 3 with with IN cord-328396-p2gvpe8i 97 4 bacterial bacterial JJ cord-328396-p2gvpe8i 97 5 sepsis sepsis NN cord-328396-p2gvpe8i 97 6 , , , cord-328396-p2gvpe8i 97 7 PCT PCT NNP cord-328396-p2gvpe8i 97 8 values value NNS cord-328396-p2gvpe8i 97 9 would would MD cord-328396-p2gvpe8i 97 10 remain remain VB cord-328396-p2gvpe8i 97 11 within within IN cord-328396-p2gvpe8i 97 12 the the DT cord-328396-p2gvpe8i 97 13 reference reference NN cord-328396-p2gvpe8i 97 14 range range NN cord-328396-p2gvpe8i 97 15 in in IN cord-328396-p2gvpe8i 97 16 viral viral JJ cord-328396-p2gvpe8i 97 17 sepsis sepsis NN cord-328396-p2gvpe8i 97 18 including include VBG cord-328396-p2gvpe8i 97 19 severe severe JJ cord-328396-p2gvpe8i 97 20 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 97 21 patients patient NNS cord-328396-p2gvpe8i 97 22 as as IN cord-328396-p2gvpe8i 97 23 PCT pct NN cord-328396-p2gvpe8i 97 24 synthesis synthesis NN cord-328396-p2gvpe8i 97 25 is be VBZ cord-328396-p2gvpe8i 97 26 known know VBN cord-328396-p2gvpe8i 97 27 to to TO cord-328396-p2gvpe8i 97 28 be be VB cord-328396-p2gvpe8i 97 29 inhibited inhibit VBN cord-328396-p2gvpe8i 97 30 by by IN cord-328396-p2gvpe8i 97 31 interferon interferon NN cord-328396-p2gvpe8i 97 32 - - HYPH cord-328396-p2gvpe8i 97 33 gamma gamma NN cord-328396-p2gvpe8i 97 34 released release VBN cord-328396-p2gvpe8i 97 35 during during IN cord-328396-p2gvpe8i 97 36 viral viral JJ cord-328396-p2gvpe8i 97 37 infections infection NNS cord-328396-p2gvpe8i 97 38 ( ( -LRB- cord-328396-p2gvpe8i 97 39 Lippi Lippi NNP cord-328396-p2gvpe8i 97 40 and and CC cord-328396-p2gvpe8i 97 41 Plebani Plebani NNP cord-328396-p2gvpe8i 97 42 , , , cord-328396-p2gvpe8i 97 43 2020 2020 CD cord-328396-p2gvpe8i 97 44 ) ) -RRB- cord-328396-p2gvpe8i 97 45 . . . cord-328396-p2gvpe8i 98 1 A a DT cord-328396-p2gvpe8i 98 2 recent recent JJ cord-328396-p2gvpe8i 98 3 elegant elegant JJ cord-328396-p2gvpe8i 98 4 study study NN cord-328396-p2gvpe8i 98 5 has have VBZ cord-328396-p2gvpe8i 98 6 identified identify VBN cord-328396-p2gvpe8i 98 7 unique unique JJ cord-328396-p2gvpe8i 98 8 immune immune JJ cord-328396-p2gvpe8i 98 9 signatures signature NNS cord-328396-p2gvpe8i 98 10 in in IN cord-328396-p2gvpe8i 98 11 severe severe JJ cord-328396-p2gvpe8i 98 12 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 98 13 patients patient NNS cord-328396-p2gvpe8i 98 14 , , , cord-328396-p2gvpe8i 98 15 characterized characterize VBN cord-328396-p2gvpe8i 98 16 by by IN cord-328396-p2gvpe8i 98 17 a a DT cord-328396-p2gvpe8i 98 18 high high JJ cord-328396-p2gvpe8i 98 19 sustained sustain VBN cord-328396-p2gvpe8i 98 20 cytokine cytokine NN cord-328396-p2gvpe8i 98 21 production production NN cord-328396-p2gvpe8i 98 22 of of IN cord-328396-p2gvpe8i 98 23 interleukin-6 interleukin-6 NNP cord-328396-p2gvpe8i 98 24 ( ( -LRB- cord-328396-p2gvpe8i 98 25 IL-6 IL-6 NNP cord-328396-p2gvpe8i 98 26 ) ) -RRB- cord-328396-p2gvpe8i 98 27 , , , cord-328396-p2gvpe8i 98 28 a a DT cord-328396-p2gvpe8i 98 29 pleiotropic pleiotropic JJ cord-328396-p2gvpe8i 98 30 cytokine cytokine NN cord-328396-p2gvpe8i 98 31 with with IN cord-328396-p2gvpe8i 98 32 multiple multiple JJ cord-328396-p2gvpe8i 98 33 effects effect NNS cord-328396-p2gvpe8i 98 34 in in IN cord-328396-p2gvpe8i 98 35 these these DT cord-328396-p2gvpe8i 98 36 patients patient NNS cord-328396-p2gvpe8i 98 37 , , , cord-328396-p2gvpe8i 98 38 distinct distinct JJ cord-328396-p2gvpe8i 98 39 from from IN cord-328396-p2gvpe8i 98 40 patients patient NNS cord-328396-p2gvpe8i 98 41 with with IN cord-328396-p2gvpe8i 98 42 bacterial bacterial JJ cord-328396-p2gvpe8i 98 43 sepsis sepsis NN cord-328396-p2gvpe8i 98 44 . . . cord-328396-p2gvpe8i 99 1 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 99 2 patients patient NNS cord-328396-p2gvpe8i 99 3 also also RB cord-328396-p2gvpe8i 99 4 show show VBP cord-328396-p2gvpe8i 99 5 IL-6-mediated il-6-mediated JJ cord-328396-p2gvpe8i 99 6 low low JJ cord-328396-p2gvpe8i 99 7 HLA HLA NNP cord-328396-p2gvpe8i 99 8 - - HYPH cord-328396-p2gvpe8i 99 9 DR DR NNP cord-328396-p2gvpe8i 99 10 expression expression NN cord-328396-p2gvpe8i 99 11 and and CC cord-328396-p2gvpe8i 99 12 lymphopenia lymphopenia NNP cord-328396-p2gvpe8i 100 1 ( ( -LRB- cord-328396-p2gvpe8i 100 2 Giamarellos Giamarellos NNP cord-328396-p2gvpe8i 100 3 - - HYPH cord-328396-p2gvpe8i 100 4 Bourboulis Bourboulis NNP cord-328396-p2gvpe8i 100 5 et et NNP cord-328396-p2gvpe8i 100 6 al al NNP cord-328396-p2gvpe8i 100 7 . . NNP cord-328396-p2gvpe8i 100 8 , , , cord-328396-p2gvpe8i 100 9 2020 2020 CD cord-328396-p2gvpe8i 100 10 ) ) -RRB- cord-328396-p2gvpe8i 100 11 . . . cord-328396-p2gvpe8i 101 1 Further further JJ cord-328396-p2gvpe8i 101 2 such such JJ cord-328396-p2gvpe8i 101 3 large large JJ cord-328396-p2gvpe8i 101 4 - - HYPH cord-328396-p2gvpe8i 101 5 scale scale NN cord-328396-p2gvpe8i 101 6 studies study NNS cord-328396-p2gvpe8i 101 7 would would MD cord-328396-p2gvpe8i 101 8 shed shed VB cord-328396-p2gvpe8i 101 9 light light NN cord-328396-p2gvpe8i 101 10 on on IN cord-328396-p2gvpe8i 101 11 how how WRB cord-328396-p2gvpe8i 101 12 COVID-19-mediated covid-19-mediated JJ cord-328396-p2gvpe8i 101 13 sepsis sepsis NN cord-328396-p2gvpe8i 101 14 is be VBZ cord-328396-p2gvpe8i 101 15 similar similar JJ cord-328396-p2gvpe8i 101 16 and/or and/or CC cord-328396-p2gvpe8i 101 17 different different JJ cord-328396-p2gvpe8i 101 18 from from IN cord-328396-p2gvpe8i 101 19 bacterial bacterial JJ cord-328396-p2gvpe8i 101 20 sepsis sepsis NN cord-328396-p2gvpe8i 101 21 to to TO cord-328396-p2gvpe8i 101 22 avoid avoid VB cord-328396-p2gvpe8i 101 23 overlapping overlap VBG cord-328396-p2gvpe8i 101 24 of of IN cord-328396-p2gvpe8i 101 25 the the DT cord-328396-p2gvpe8i 101 26 two two CD cord-328396-p2gvpe8i 101 27 distinct distinct JJ cord-328396-p2gvpe8i 101 28 diseases disease NNS cord-328396-p2gvpe8i 101 29 . . . cord-328396-p2gvpe8i 102 1 Directly directly RB cord-328396-p2gvpe8i 102 2 or or CC cord-328396-p2gvpe8i 102 3 indirectly indirectly RB cord-328396-p2gvpe8i 102 4 , , , cord-328396-p2gvpe8i 102 5 endothelial endothelial JJ cord-328396-p2gvpe8i 102 6 cells cell NNS cord-328396-p2gvpe8i 102 7 and and CC cord-328396-p2gvpe8i 102 8 particularly particularly RB cord-328396-p2gvpe8i 102 9 mECs mecs UH cord-328396-p2gvpe8i 102 10 are be VBP cord-328396-p2gvpe8i 102 11 a a DT cord-328396-p2gvpe8i 102 12 crucial crucial JJ cord-328396-p2gvpe8i 102 13 link link NN cord-328396-p2gvpe8i 102 14 between between IN cord-328396-p2gvpe8i 102 15 SARS SARS NNP cord-328396-p2gvpe8i 102 16 - - HYPH cord-328396-p2gvpe8i 102 17 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 102 18 and and CC cord-328396-p2gvpe8i 102 19 host host VB cord-328396-p2gvpe8i 102 20 immune immune JJ cord-328396-p2gvpe8i 102 21 responses response NNS cord-328396-p2gvpe8i 102 22 and and CC cord-328396-p2gvpe8i 102 23 thus thus RB cord-328396-p2gvpe8i 102 24 may may MD cord-328396-p2gvpe8i 102 25 serve serve VB cord-328396-p2gvpe8i 102 26 many many JJ cord-328396-p2gvpe8i 102 27 roles role NNS cord-328396-p2gvpe8i 102 28 in in IN cord-328396-p2gvpe8i 102 29 determining determine VBG cord-328396-p2gvpe8i 102 30 the the DT cord-328396-p2gvpe8i 102 31 disease disease NN cord-328396-p2gvpe8i 102 32 severity severity NN cord-328396-p2gvpe8i 102 33 and and CC cord-328396-p2gvpe8i 102 34 mortality mortality NN cord-328396-p2gvpe8i 102 35 in in IN cord-328396-p2gvpe8i 102 36 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 102 37 ( ( -LRB- cord-328396-p2gvpe8i 102 38 Figure figure NN cord-328396-p2gvpe8i 102 39 1 1 CD cord-328396-p2gvpe8i 102 40 ) ) -RRB- cord-328396-p2gvpe8i 102 41 . . . cord-328396-p2gvpe8i 103 1 As as IN cord-328396-p2gvpe8i 103 2 the the DT cord-328396-p2gvpe8i 103 3 clinical clinical JJ cord-328396-p2gvpe8i 103 4 , , , cord-328396-p2gvpe8i 103 5 pathological pathological JJ cord-328396-p2gvpe8i 103 6 and and CC cord-328396-p2gvpe8i 103 7 molecular molecular JJ cord-328396-p2gvpe8i 103 8 features feature NNS cord-328396-p2gvpe8i 103 9 of of IN cord-328396-p2gvpe8i 103 10 COVID-19 covid-19 CD cord-328396-p2gvpe8i 103 11 patients patient NNS cord-328396-p2gvpe8i 103 12 are be VBP cord-328396-p2gvpe8i 103 13 unfolding unfold VBG cord-328396-p2gvpe8i 103 14 in in IN cord-328396-p2gvpe8i 103 15 investigational investigational JJ cord-328396-p2gvpe8i 103 16 studies study NNS cord-328396-p2gvpe8i 103 17 , , , cord-328396-p2gvpe8i 103 18 several several JJ cord-328396-p2gvpe8i 103 19 researchers researcher NNS cord-328396-p2gvpe8i 103 20 are be VBP cord-328396-p2gvpe8i 103 21 hypothesizing hypothesize VBG cord-328396-p2gvpe8i 103 22 and and CC cord-328396-p2gvpe8i 103 23 reviewing review VBG cord-328396-p2gvpe8i 103 24 a a DT cord-328396-p2gvpe8i 103 25 vascular vascular JJ cord-328396-p2gvpe8i 103 26 - - HYPH cord-328396-p2gvpe8i 103 27 centric centric NN cord-328396-p2gvpe8i 103 28 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 103 29 of of IN cord-328396-p2gvpe8i 103 30 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 103 31 . . . cord-328396-p2gvpe8i 104 1 A a DT cord-328396-p2gvpe8i 104 2 summary summary NN cord-328396-p2gvpe8i 104 3 of of IN cord-328396-p2gvpe8i 104 4 such such JJ cord-328396-p2gvpe8i 104 5 recent recent JJ cord-328396-p2gvpe8i 104 6 reviews review NNS cord-328396-p2gvpe8i 104 7 and and CC cord-328396-p2gvpe8i 104 8 short short JJ cord-328396-p2gvpe8i 104 9 reports report NNS cord-328396-p2gvpe8i 104 10 is be VBZ cord-328396-p2gvpe8i 104 11 provided provide VBN cord-328396-p2gvpe8i 104 12 in in IN cord-328396-p2gvpe8i 104 13 Table Table NNP cord-328396-p2gvpe8i 104 14 1 1 CD cord-328396-p2gvpe8i 105 1 ( ( -LRB- cord-328396-p2gvpe8i 105 2 Alvarado Alvarado NNP cord-328396-p2gvpe8i 105 3 - - HYPH cord-328396-p2gvpe8i 105 4 Moreno Moreno NNP cord-328396-p2gvpe8i 105 5 and and CC cord-328396-p2gvpe8i 105 6 Majluf Majluf NNP cord-328396-p2gvpe8i 105 7 - - HYPH cord-328396-p2gvpe8i 105 8 Cruz Cruz NNP cord-328396-p2gvpe8i 105 9 , , , cord-328396-p2gvpe8i 105 10 2020 2020 CD cord-328396-p2gvpe8i 105 11 ; ; . cord-328396-p2gvpe8i 106 1 Amraei Amraei NNP cord-328396-p2gvpe8i 106 2 and and CC cord-328396-p2gvpe8i 106 3 Rahimi Rahimi NNP cord-328396-p2gvpe8i 106 4 , , , cord-328396-p2gvpe8i 106 5 2020 2020 CD cord-328396-p2gvpe8i 106 6 ; ; : cord-328396-p2gvpe8i 106 7 Cure cure NN cord-328396-p2gvpe8i 106 8 and and CC cord-328396-p2gvpe8i 106 9 Cure cure NN cord-328396-p2gvpe8i 106 10 , , , cord-328396-p2gvpe8i 106 11 2020 2020 CD cord-328396-p2gvpe8i 106 12 ; ; : cord-328396-p2gvpe8i 106 13 Froldi Froldi NNP cord-328396-p2gvpe8i 106 14 and and CC cord-328396-p2gvpe8i 106 15 Dorigo Dorigo NNP cord-328396-p2gvpe8i 106 16 , , , cord-328396-p2gvpe8i 106 17 2020 2020 CD cord-328396-p2gvpe8i 106 18 ; ; : cord-328396-p2gvpe8i 106 19 Guler Guler NNP cord-328396-p2gvpe8i 106 20 et et NNP cord-328396-p2gvpe8i 106 21 al al NNP cord-328396-p2gvpe8i 106 22 . . NNP cord-328396-p2gvpe8i 106 23 , , , cord-328396-p2gvpe8i 106 24 2020 2020 CD cord-328396-p2gvpe8i 106 25 ; ; : cord-328396-p2gvpe8i 106 26 Gupta Gupta NNP cord-328396-p2gvpe8i 106 27 et et NNP cord-328396-p2gvpe8i 106 28 al al NNP cord-328396-p2gvpe8i 106 29 . . NNP cord-328396-p2gvpe8i 106 30 , , , cord-328396-p2gvpe8i 106 31 2020 2020 CD cord-328396-p2gvpe8i 106 32 ; ; : cord-328396-p2gvpe8i 106 33 Gustafson Gustafson NNP cord-328396-p2gvpe8i 106 34 et et NNP cord-328396-p2gvpe8i 106 35 al al NNP cord-328396-p2gvpe8i 106 36 . . NNP cord-328396-p2gvpe8i 106 37 , , , cord-328396-p2gvpe8i 106 38 2020 2020 CD cord-328396-p2gvpe8i 106 39 ; ; : cord-328396-p2gvpe8i 106 40 Mangalmurti Mangalmurti NNP cord-328396-p2gvpe8i 106 41 et et NNP cord-328396-p2gvpe8i 106 42 al al NNP cord-328396-p2gvpe8i 106 43 . . NNP cord-328396-p2gvpe8i 106 44 , , , cord-328396-p2gvpe8i 106 45 2020 2020 CD cord-328396-p2gvpe8i 106 46 ; ; : cord-328396-p2gvpe8i 106 47 Marchetti Marchetti NNP cord-328396-p2gvpe8i 106 48 , , , cord-328396-p2gvpe8i 106 49 2020 2020 CD cord-328396-p2gvpe8i 106 50 ; ; : cord-328396-p2gvpe8i 106 51 Mondal Mondal NNP cord-328396-p2gvpe8i 106 52 et et FW cord-328396-p2gvpe8i 106 53 al al NNP cord-328396-p2gvpe8i 106 54 . . NNP cord-328396-p2gvpe8i 106 55 , , , cord-328396-p2gvpe8i 106 56 2020 2020 CD cord-328396-p2gvpe8i 106 57 ; ; : cord-328396-p2gvpe8i 106 58 Panfoli Panfoli NNP cord-328396-p2gvpe8i 106 59 , , , cord-328396-p2gvpe8i 106 60 2020 2020 CD cord-328396-p2gvpe8i 106 61 ; ; : cord-328396-p2gvpe8i 106 62 Pons Pons NNP cord-328396-p2gvpe8i 106 63 et et NNP cord-328396-p2gvpe8i 106 64 al al NNP cord-328396-p2gvpe8i 106 65 . . NNP cord-328396-p2gvpe8i 106 66 , , , cord-328396-p2gvpe8i 106 67 2020 2020 CD cord-328396-p2gvpe8i 106 68 ; ; : cord-328396-p2gvpe8i 106 69 Sardu Sardu NNP cord-328396-p2gvpe8i 106 70 et et FW cord-328396-p2gvpe8i 106 71 al al NNP cord-328396-p2gvpe8i 106 72 . . NNP cord-328396-p2gvpe8i 106 73 , , , cord-328396-p2gvpe8i 106 74 2020b 2020b CD cord-328396-p2gvpe8i 106 75 ; ; : cord-328396-p2gvpe8i 106 76 Teuwen Teuwen NNP cord-328396-p2gvpe8i 106 77 et et NNP cord-328396-p2gvpe8i 106 78 al al NNP cord-328396-p2gvpe8i 106 79 . . NNP cord-328396-p2gvpe8i 106 80 , , , cord-328396-p2gvpe8i 106 81 2020 2020 CD cord-328396-p2gvpe8i 106 82 ) ) -RRB- cord-328396-p2gvpe8i 106 83 . . . cord-328396-p2gvpe8i 107 1 Hence hence RB cord-328396-p2gvpe8i 107 2 , , , cord-328396-p2gvpe8i 107 3 undoubtedly undoubtedly RB cord-328396-p2gvpe8i 107 4 , , , cord-328396-p2gvpe8i 107 5 an an DT cord-328396-p2gvpe8i 107 6 assessment assessment NN cord-328396-p2gvpe8i 107 7 of of IN cord-328396-p2gvpe8i 107 8 endothelial endothelial JJ cord-328396-p2gvpe8i 107 9 dysfunction dysfunction NN cord-328396-p2gvpe8i 107 10 in in IN cord-328396-p2gvpe8i 107 11 patients patient NNS cord-328396-p2gvpe8i 107 12 with with IN cord-328396-p2gvpe8i 107 13 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 107 14 to to TO cord-328396-p2gvpe8i 107 15 stratify stratify VB cord-328396-p2gvpe8i 107 16 the the DT cord-328396-p2gvpe8i 107 17 patients patient NNS cord-328396-p2gvpe8i 107 18 based base VBN cord-328396-p2gvpe8i 107 19 on on IN cord-328396-p2gvpe8i 107 20 severity severity NN cord-328396-p2gvpe8i 107 21 holds hold VBZ cord-328396-p2gvpe8i 107 22 immense immense JJ cord-328396-p2gvpe8i 107 23 relevance relevance NN cord-328396-p2gvpe8i 107 24 . . . cord-328396-p2gvpe8i 108 1 Circulating circulate VBG cord-328396-p2gvpe8i 108 2 biomarkers biomarker NNS cord-328396-p2gvpe8i 108 3 such such JJ cord-328396-p2gvpe8i 108 4 as as IN cord-328396-p2gvpe8i 108 5 endothelin-1 endothelin-1 NNP cord-328396-p2gvpe8i 108 6 , , , cord-328396-p2gvpe8i 108 7 E e NN cord-328396-p2gvpe8i 108 8 - - : cord-328396-p2gvpe8i 108 9 and and CC cord-328396-p2gvpe8i 108 10 P p NN cord-328396-p2gvpe8i 108 11 - - HYPH cord-328396-p2gvpe8i 108 12 selectins selectin NNS cord-328396-p2gvpe8i 108 13 , , , cord-328396-p2gvpe8i 108 14 vWF vwf NN cord-328396-p2gvpe8i 108 15 and and CC cord-328396-p2gvpe8i 108 16 soluble soluble JJ cord-328396-p2gvpe8i 108 17 adhesion adhesion NN cord-328396-p2gvpe8i 108 18 molecules molecule NNS cord-328396-p2gvpe8i 108 19 that that WDT cord-328396-p2gvpe8i 108 20 signify signify VBP cord-328396-p2gvpe8i 108 21 endothelial endothelial JJ cord-328396-p2gvpe8i 108 22 dysfunction dysfunction NN cord-328396-p2gvpe8i 108 23 may may MD cord-328396-p2gvpe8i 108 24 appear appear VB cord-328396-p2gvpe8i 108 25 as as IN cord-328396-p2gvpe8i 108 26 early early JJ cord-328396-p2gvpe8i 108 27 biomarkers biomarker NNS cord-328396-p2gvpe8i 108 28 of of IN cord-328396-p2gvpe8i 108 29 viral viral JJ cord-328396-p2gvpe8i 108 30 infection infection NN cord-328396-p2gvpe8i 108 31 and and CC cord-328396-p2gvpe8i 108 32 probable probable JJ cord-328396-p2gvpe8i 108 33 organ organ NN cord-328396-p2gvpe8i 108 34 dysfunction dysfunction NN cord-328396-p2gvpe8i 109 1 ( ( -LRB- cord-328396-p2gvpe8i 109 2 Goshua Goshua NNP cord-328396-p2gvpe8i 109 3 et et NNP cord-328396-p2gvpe8i 109 4 al al NNP cord-328396-p2gvpe8i 109 5 . . NNP cord-328396-p2gvpe8i 109 6 , , , cord-328396-p2gvpe8i 109 7 2020 2020 CD cord-328396-p2gvpe8i 109 8 ) ) -RRB- cord-328396-p2gvpe8i 109 9 . . . cord-328396-p2gvpe8i 110 1 Pulmonary pulmonary JJ cord-328396-p2gvpe8i 110 2 endothelium endothelium NN cord-328396-p2gvpe8i 110 3 has have VBZ cord-328396-p2gvpe8i 110 4 the the DT cord-328396-p2gvpe8i 110 5 highest high JJS cord-328396-p2gvpe8i 110 6 expression expression NN cord-328396-p2gvpe8i 110 7 of of IN cord-328396-p2gvpe8i 110 8 the the DT cord-328396-p2gvpe8i 110 9 angiogenic angiogenic JJ cord-328396-p2gvpe8i 110 10 factors factor NNS cord-328396-p2gvpe8i 110 11 like like IN cord-328396-p2gvpe8i 110 12 , , , cord-328396-p2gvpe8i 110 13 vascular vascular JJ cord-328396-p2gvpe8i 110 14 endothelial endothelial JJ cord-328396-p2gvpe8i 110 15 growth growth NN cord-328396-p2gvpe8i 110 16 factor factor NN cord-328396-p2gvpe8i 110 17 ( ( -LRB- cord-328396-p2gvpe8i 110 18 VEGF VEGF NNP cord-328396-p2gvpe8i 110 19 ) ) -RRB- cord-328396-p2gvpe8i 110 20 and and CC cord-328396-p2gvpe8i 110 21 a a DT cord-328396-p2gvpe8i 110 22 dysregulated dysregulate VBN cord-328396-p2gvpe8i 110 23 pulmonary pulmonary JJ cord-328396-p2gvpe8i 110 24 angiogenesis angiogenesis NN cord-328396-p2gvpe8i 110 25 is be VBZ cord-328396-p2gvpe8i 110 26 a a DT cord-328396-p2gvpe8i 110 27 well well RB cord-328396-p2gvpe8i 110 28 - - HYPH cord-328396-p2gvpe8i 110 29 known know VBN cord-328396-p2gvpe8i 110 30 mediator mediator NN cord-328396-p2gvpe8i 110 31 of of IN cord-328396-p2gvpe8i 110 32 acute acute JJ cord-328396-p2gvpe8i 110 33 lung lung NN cord-328396-p2gvpe8i 110 34 injury injury NN cord-328396-p2gvpe8i 111 1 ( ( -LRB- cord-328396-p2gvpe8i 111 2 Wada Wada NNP cord-328396-p2gvpe8i 111 3 et et NNP cord-328396-p2gvpe8i 111 4 al al NNP cord-328396-p2gvpe8i 111 5 . . NNP cord-328396-p2gvpe8i 111 6 , , , cord-328396-p2gvpe8i 111 7 2013 2013 CD cord-328396-p2gvpe8i 111 8 ) ) -RRB- cord-328396-p2gvpe8i 111 9 . . . cord-328396-p2gvpe8i 112 1 FIGURE figure NN cord-328396-p2gvpe8i 112 2 1 1 CD cord-328396-p2gvpe8i 113 1 | | NFP cord-328396-p2gvpe8i 113 2 Probable probable JJ cord-328396-p2gvpe8i 113 3 Interactions Interactions NNPS cord-328396-p2gvpe8i 113 4 of of IN cord-328396-p2gvpe8i 113 5 SARS SARS NNP cord-328396-p2gvpe8i 113 6 - - HYPH cord-328396-p2gvpe8i 113 7 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 113 8 with with IN cord-328396-p2gvpe8i 113 9 pulmonary pulmonary JJ cord-328396-p2gvpe8i 113 10 microvascular microvascular JJ cord-328396-p2gvpe8i 113 11 endothelial endothelial JJ cord-328396-p2gvpe8i 113 12 cells cell NNS cord-328396-p2gvpe8i 113 13 ( ( -LRB- cord-328396-p2gvpe8i 113 14 mECs mecs NN cord-328396-p2gvpe8i 113 15 ) ) -RRB- cord-328396-p2gvpe8i 113 16 . . . cord-328396-p2gvpe8i 114 1 SARS SARS NNP cord-328396-p2gvpe8i 114 2 - - HYPH cord-328396-p2gvpe8i 114 3 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 114 4 may may MD cord-328396-p2gvpe8i 114 5 interact interact VB cord-328396-p2gvpe8i 114 6 with with IN cord-328396-p2gvpe8i 114 7 the the DT cord-328396-p2gvpe8i 114 8 mECs mecs NN cord-328396-p2gvpe8i 114 9 directly directly RB cord-328396-p2gvpe8i 114 10 via via IN cord-328396-p2gvpe8i 114 11 ACE2 ACE2 NNP cord-328396-p2gvpe8i 114 12 receptor receptor NN cord-328396-p2gvpe8i 114 13 or or CC cord-328396-p2gvpe8i 114 14 indirectly indirectly RB cord-328396-p2gvpe8i 114 15 affecting affect VBG cord-328396-p2gvpe8i 114 16 a a DT cord-328396-p2gvpe8i 114 17 multitude multitude NN cord-328396-p2gvpe8i 114 18 of of IN cord-328396-p2gvpe8i 114 19 endothelial endothelial RB cord-328396-p2gvpe8i 114 20 - - HYPH cord-328396-p2gvpe8i 114 21 mediated mediate VBN cord-328396-p2gvpe8i 114 22 functions function NNS cord-328396-p2gvpe8i 114 23 including include VBG cord-328396-p2gvpe8i 114 24 changes change NNS cord-328396-p2gvpe8i 114 25 in in IN cord-328396-p2gvpe8i 114 26 intercellular intercellular JJ cord-328396-p2gvpe8i 114 27 permeability permeability NN cord-328396-p2gvpe8i 114 28 , , , cord-328396-p2gvpe8i 114 29 expression expression NN cord-328396-p2gvpe8i 114 30 of of IN cord-328396-p2gvpe8i 114 31 selections selection NNS cord-328396-p2gvpe8i 114 32 , , , cord-328396-p2gvpe8i 114 33 adhesins adhesin NNS cord-328396-p2gvpe8i 114 34 and and CC cord-328396-p2gvpe8i 114 35 VE VE NNP cord-328396-p2gvpe8i 114 36 - - HYPH cord-328396-p2gvpe8i 114 37 cadherins cadherin NNS cord-328396-p2gvpe8i 114 38 , , , cord-328396-p2gvpe8i 114 39 changes change NNS cord-328396-p2gvpe8i 114 40 in in IN cord-328396-p2gvpe8i 114 41 expression expression NN cord-328396-p2gvpe8i 114 42 of of IN cord-328396-p2gvpe8i 114 43 angiogenic angiogenic JJ cord-328396-p2gvpe8i 114 44 and and CC cord-328396-p2gvpe8i 114 45 other other JJ cord-328396-p2gvpe8i 114 46 functional functional JJ cord-328396-p2gvpe8i 114 47 receptors receptor NNS cord-328396-p2gvpe8i 114 48 such such JJ cord-328396-p2gvpe8i 114 49 as as IN cord-328396-p2gvpe8i 114 50 VEGFR1/2 VEGFR1/2 NNP cord-328396-p2gvpe8i 114 51 , , , cord-328396-p2gvpe8i 114 52 PDGFBR PDGFBR NNP cord-328396-p2gvpe8i 114 53 , , , cord-328396-p2gvpe8i 114 54 S1P S1P VBD cord-328396-p2gvpe8i 114 55 2/4 2/4 CD cord-328396-p2gvpe8i 114 56 , , , cord-328396-p2gvpe8i 114 57 PECAMs pecam NNS cord-328396-p2gvpe8i 114 58 , , , cord-328396-p2gvpe8i 114 59 ICAMs icam NNS cord-328396-p2gvpe8i 114 60 , , , cord-328396-p2gvpe8i 114 61 VCAM1 VCAM1 NNP cord-328396-p2gvpe8i 114 62 causing cause VBG cord-328396-p2gvpe8i 114 63 neutrophilia neutrophilia NNP cord-328396-p2gvpe8i 114 64 , , , cord-328396-p2gvpe8i 114 65 formation formation NN cord-328396-p2gvpe8i 114 66 of of IN cord-328396-p2gvpe8i 114 67 neutrophil neutrophil NN cord-328396-p2gvpe8i 114 68 extracellular extracellular JJ cord-328396-p2gvpe8i 114 69 traps trap NNS cord-328396-p2gvpe8i 114 70 ( ( -LRB- cord-328396-p2gvpe8i 114 71 NETs nets NN cord-328396-p2gvpe8i 114 72 ) ) -RRB- cord-328396-p2gvpe8i 114 73 , , , cord-328396-p2gvpe8i 114 74 inflammation inflammation NN cord-328396-p2gvpe8i 114 75 , , , cord-328396-p2gvpe8i 114 76 hypercoagulation hypercoagulation NN cord-328396-p2gvpe8i 114 77 and and CC cord-328396-p2gvpe8i 114 78 hypoxia hypoxia NN cord-328396-p2gvpe8i 114 79 . . . cord-328396-p2gvpe8i 115 1 Hypoxia hypoxia NN cord-328396-p2gvpe8i 115 2 causes cause VBZ cord-328396-p2gvpe8i 115 3 induction induction NN cord-328396-p2gvpe8i 115 4 of of IN cord-328396-p2gvpe8i 115 5 hypoxia hypoxia NN cord-328396-p2gvpe8i 115 6 - - HYPH cord-328396-p2gvpe8i 115 7 inducible inducible JJ cord-328396-p2gvpe8i 115 8 factors factor NNS cord-328396-p2gvpe8i 115 9 ( ( -LRB- cord-328396-p2gvpe8i 115 10 HIF-1 HIF-1 NNP cord-328396-p2gvpe8i 115 11 ) ) -RRB- cord-328396-p2gvpe8i 115 12 and and CC cord-328396-p2gvpe8i 115 13 angiogenesis angiogenesis NN cord-328396-p2gvpe8i 115 14 . . . cord-328396-p2gvpe8i 116 1 ROS ROS NNP cord-328396-p2gvpe8i 116 2 from from IN cord-328396-p2gvpe8i 116 3 activated activate VBN cord-328396-p2gvpe8i 116 4 neutrophils neutrophil NNS cord-328396-p2gvpe8i 116 5 induces induce VBZ cord-328396-p2gvpe8i 116 6 expression expression NN cord-328396-p2gvpe8i 116 7 of of IN cord-328396-p2gvpe8i 116 8 transcription transcription NN cord-328396-p2gvpe8i 116 9 factors factor NNS cord-328396-p2gvpe8i 116 10 , , , cord-328396-p2gvpe8i 116 11 Nrf2 Nrf2 NNP cord-328396-p2gvpe8i 116 12 and and CC cord-328396-p2gvpe8i 116 13 NFk NFk NNPS cord-328396-p2gvpe8i 116 14 - - HYPH cord-328396-p2gvpe8i 116 15 B b NN cord-328396-p2gvpe8i 116 16 , , , cord-328396-p2gvpe8i 116 17 causing cause VBG cord-328396-p2gvpe8i 116 18 further further JJ cord-328396-p2gvpe8i 116 19 inflammation inflammation NN cord-328396-p2gvpe8i 116 20 . . . cord-328396-p2gvpe8i 117 1 These these DT cord-328396-p2gvpe8i 117 2 changes change NNS cord-328396-p2gvpe8i 117 3 in in IN cord-328396-p2gvpe8i 117 4 mECs mecs NN cord-328396-p2gvpe8i 117 5 result result VB cord-328396-p2gvpe8i 117 6 in in IN cord-328396-p2gvpe8i 117 7 an an DT cord-328396-p2gvpe8i 117 8 increase increase NN cord-328396-p2gvpe8i 117 9 / / SYM cord-328396-p2gvpe8i 117 10 decrease decrease NN cord-328396-p2gvpe8i 117 11 of of IN cord-328396-p2gvpe8i 117 12 vaso vaso NN cord-328396-p2gvpe8i 117 13 - - HYPH cord-328396-p2gvpe8i 117 14 active active JJ cord-328396-p2gvpe8i 117 15 mediators mediator NNS cord-328396-p2gvpe8i 117 16 like like IN cord-328396-p2gvpe8i 117 17 nitric nitric NN cord-328396-p2gvpe8i 117 18 oxide oxide NN cord-328396-p2gvpe8i 117 19 ( ( -LRB- cord-328396-p2gvpe8i 117 20 NO no UH cord-328396-p2gvpe8i 117 21 ) ) -RRB- cord-328396-p2gvpe8i 117 22 , , , cord-328396-p2gvpe8i 117 23 endothelin-1 endothelin-1 NNP cord-328396-p2gvpe8i 117 24 , , , cord-328396-p2gvpe8i 117 25 oxygen oxygen NN cord-328396-p2gvpe8i 117 26 sensing sensing NN cord-328396-p2gvpe8i 117 27 machinery machinery NN cord-328396-p2gvpe8i 117 28 , , , cord-328396-p2gvpe8i 117 29 impaired impair VBN cord-328396-p2gvpe8i 117 30 hypoxic hypoxic JJ cord-328396-p2gvpe8i 117 31 vasoconstriction vasoconstriction NN cord-328396-p2gvpe8i 117 32 and and CC cord-328396-p2gvpe8i 117 33 V v NN cord-328396-p2gvpe8i 117 34 / / SYM cord-328396-p2gvpe8i 117 35 Q q NN cord-328396-p2gvpe8i 117 36 mismatch mismatch NN cord-328396-p2gvpe8i 117 37 . . . cord-328396-p2gvpe8i 118 1 In in IN cord-328396-p2gvpe8i 118 2 inflammatory inflammatory JJ cord-328396-p2gvpe8i 118 3 states state NNS cord-328396-p2gvpe8i 118 4 , , , cord-328396-p2gvpe8i 118 5 the the DT cord-328396-p2gvpe8i 118 6 mECs mec NNS cord-328396-p2gvpe8i 118 7 are be VBP cord-328396-p2gvpe8i 118 8 also also RB cord-328396-p2gvpe8i 118 9 subjected subject VBN cord-328396-p2gvpe8i 118 10 to to IN cord-328396-p2gvpe8i 118 11 disturbed disturbed VB cord-328396-p2gvpe8i 118 12 blood blood NN cord-328396-p2gvpe8i 118 13 flow flow NN cord-328396-p2gvpe8i 118 14 ( ( -LRB- cord-328396-p2gvpe8i 118 15 shear shear NN cord-328396-p2gvpe8i 118 16 stress stress NN cord-328396-p2gvpe8i 118 17 ) ) -RRB- cord-328396-p2gvpe8i 118 18 . . . cord-328396-p2gvpe8i 119 1 mES mES NNP cord-328396-p2gvpe8i 119 2 dysfunction dysfunction NN cord-328396-p2gvpe8i 119 3 may may MD cord-328396-p2gvpe8i 119 4 also also RB cord-328396-p2gvpe8i 119 5 cause cause VB cord-328396-p2gvpe8i 119 6 an an DT cord-328396-p2gvpe8i 119 7 increase increase NN cord-328396-p2gvpe8i 119 8 in in IN cord-328396-p2gvpe8i 119 9 the the DT cord-328396-p2gvpe8i 119 10 expression expression NN cord-328396-p2gvpe8i 119 11 of of IN cord-328396-p2gvpe8i 119 12 PD PD NNP cord-328396-p2gvpe8i 119 13 - - HYPH cord-328396-p2gvpe8i 119 14 L1 L1 NNP cord-328396-p2gvpe8i 119 15 , , , cord-328396-p2gvpe8i 119 16 leading lead VBG cord-328396-p2gvpe8i 119 17 to to IN cord-328396-p2gvpe8i 119 18 T T NNP cord-328396-p2gvpe8i 119 19 cell cell NN cord-328396-p2gvpe8i 119 20 lymphopenia lymphopenia NNP cord-328396-p2gvpe8i 119 21 . . . cord-328396-p2gvpe8i 120 1 These these DT cord-328396-p2gvpe8i 120 2 drastic drastic JJ cord-328396-p2gvpe8i 120 3 changes change NNS cord-328396-p2gvpe8i 120 4 in in IN cord-328396-p2gvpe8i 120 5 the the DT cord-328396-p2gvpe8i 120 6 capillary capillary JJ cord-328396-p2gvpe8i 120 7 endothelium endothelium NN cord-328396-p2gvpe8i 120 8 disrupts disrupt VBZ cord-328396-p2gvpe8i 120 9 the the DT cord-328396-p2gvpe8i 120 10 alveolar alveolar NN cord-328396-p2gvpe8i 120 11 - - HYPH cord-328396-p2gvpe8i 120 12 capillary capillary JJ cord-328396-p2gvpe8i 120 13 barrier barrier NN cord-328396-p2gvpe8i 120 14 , , , cord-328396-p2gvpe8i 120 15 causing cause VBG cord-328396-p2gvpe8i 120 16 edema edema NN cord-328396-p2gvpe8i 120 17 and and CC cord-328396-p2gvpe8i 120 18 finally finally RB cord-328396-p2gvpe8i 120 19 respiratory respiratory JJ cord-328396-p2gvpe8i 120 20 distress distress NN cord-328396-p2gvpe8i 120 21 . . . cord-328396-p2gvpe8i 121 1 Frontiers frontier NNS cord-328396-p2gvpe8i 121 2 in in IN cord-328396-p2gvpe8i 121 3 Physiology Physiology NNP cord-328396-p2gvpe8i 121 4 | | NNP cord-328396-p2gvpe8i 121 5 www.frontiersin.org www.frontiersin.org NN cord-328396-p2gvpe8i 121 6 TABLE table NN cord-328396-p2gvpe8i 122 1 1 1 LS cord-328396-p2gvpe8i 122 2 | | NNP cord-328396-p2gvpe8i 122 3 Summary Summary NNP cord-328396-p2gvpe8i 122 4 of of IN cord-328396-p2gvpe8i 122 5 studies study NNS cord-328396-p2gvpe8i 122 6 hypothesizing hypothesize VBG cord-328396-p2gvpe8i 122 7 an an DT cord-328396-p2gvpe8i 122 8 endothelial endothelial RB cord-328396-p2gvpe8i 122 9 - - HYPH cord-328396-p2gvpe8i 122 10 specific specific JJ cord-328396-p2gvpe8i 122 11 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 122 12 of of IN cord-328396-p2gvpe8i 122 13 COVID-19 covid-19 NN cord-328396-p2gvpe8i 122 14 . . . cord-328396-p2gvpe8i 123 1 Major major JJ cord-328396-p2gvpe8i 123 2 views view NNS cord-328396-p2gvpe8i 123 3 Type type NN cord-328396-p2gvpe8i 123 4 of of IN cord-328396-p2gvpe8i 123 5 study study NN cord-328396-p2gvpe8i 123 6 Study study NN cord-328396-p2gvpe8i 123 7 ( ( -LRB- cord-328396-p2gvpe8i 123 8 References reference NNS cord-328396-p2gvpe8i 123 9 ) ) -RRB- cord-328396-p2gvpe8i 124 1 The the DT cord-328396-p2gvpe8i 124 2 endothelium endothelium NN cord-328396-p2gvpe8i 124 3 is be VBZ cord-328396-p2gvpe8i 124 4 a a DT cord-328396-p2gvpe8i 124 5 key key JJ cord-328396-p2gvpe8i 124 6 target target NN cord-328396-p2gvpe8i 124 7 organ organ NN cord-328396-p2gvpe8i 124 8 in in IN cord-328396-p2gvpe8i 124 9 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 124 10 and and CC cord-328396-p2gvpe8i 124 11 a a DT cord-328396-p2gvpe8i 124 12 major major JJ cord-328396-p2gvpe8i 124 13 determinant determinant NN cord-328396-p2gvpe8i 124 14 of of IN cord-328396-p2gvpe8i 124 15 disease disease NN cord-328396-p2gvpe8i 124 16 severity severity NN cord-328396-p2gvpe8i 124 17 . . . cord-328396-p2gvpe8i 125 1 Review Review NNP cord-328396-p2gvpe8i 125 2 ( ( -LRB- cord-328396-p2gvpe8i 125 3 Sardu Sardu NNP cord-328396-p2gvpe8i 125 4 et et FW cord-328396-p2gvpe8i 125 5 al al NNP cord-328396-p2gvpe8i 125 6 . . NNP cord-328396-p2gvpe8i 125 7 , , , cord-328396-p2gvpe8i 125 8 2020b 2020b CD cord-328396-p2gvpe8i 125 9 ) ) -RRB- cord-328396-p2gvpe8i 125 10 2 2 CD cord-328396-p2gvpe8i 125 11 . . . cord-328396-p2gvpe8i 126 1 Deaths death NNS cord-328396-p2gvpe8i 126 2 occurring occur VBG cord-328396-p2gvpe8i 126 3 in in IN cord-328396-p2gvpe8i 126 4 Mexico Mexico NNP cord-328396-p2gvpe8i 126 5 at at IN cord-328396-p2gvpe8i 126 6 younger young JJR cord-328396-p2gvpe8i 126 7 age age NN cord-328396-p2gvpe8i 126 8 as as IN cord-328396-p2gvpe8i 126 9 compared compare VBN cord-328396-p2gvpe8i 126 10 with with IN cord-328396-p2gvpe8i 126 11 other other JJ cord-328396-p2gvpe8i 126 12 countries country NNS cord-328396-p2gvpe8i 126 13 may may MD cord-328396-p2gvpe8i 126 14 be be VB cord-328396-p2gvpe8i 126 15 related relate VBN cord-328396-p2gvpe8i 126 16 to to IN cord-328396-p2gvpe8i 126 17 the the DT cord-328396-p2gvpe8i 126 18 high high JJ cord-328396-p2gvpe8i 126 19 frequency frequency NN cord-328396-p2gvpe8i 126 20 of of IN cord-328396-p2gvpe8i 126 21 vascular vascular JJ cord-328396-p2gvpe8i 126 22 risk risk NN cord-328396-p2gvpe8i 126 23 factors factor NNS cord-328396-p2gvpe8i 126 24 and and CC cord-328396-p2gvpe8i 126 25 the the DT cord-328396-p2gvpe8i 126 26 consequent consequent JJ cord-328396-p2gvpe8i 126 27 endothelial endothelial JJ cord-328396-p2gvpe8i 126 28 dysfunction dysfunction NN cord-328396-p2gvpe8i 126 29 . . . cord-328396-p2gvpe8i 127 1 Alvarado Alvarado NNP cord-328396-p2gvpe8i 127 2 - - HYPH cord-328396-p2gvpe8i 127 3 Moreno Moreno NNP cord-328396-p2gvpe8i 127 4 and and CC cord-328396-p2gvpe8i 127 5 Majluf Majluf NNP cord-328396-p2gvpe8i 127 6 - - HYPH cord-328396-p2gvpe8i 127 7 Cruz Cruz NNP cord-328396-p2gvpe8i 127 8 , , , cord-328396-p2gvpe8i 127 9 2020 2020 CD cord-328396-p2gvpe8i 127 10 3 3 CD cord-328396-p2gvpe8i 127 11 . . . cord-328396-p2gvpe8i 128 1 Key key JJ cord-328396-p2gvpe8i 128 2 role role NN cord-328396-p2gvpe8i 128 3 of of IN cord-328396-p2gvpe8i 128 4 endothelial endothelial JJ cord-328396-p2gvpe8i 128 5 dysfunction dysfunction NN cord-328396-p2gvpe8i 128 6 during during IN cord-328396-p2gvpe8i 128 7 SARS SARS NNP cord-328396-p2gvpe8i 128 8 - - HYPH cord-328396-p2gvpe8i 128 9 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 128 10 infection infection NN cord-328396-p2gvpe8i 128 11 , , , cord-328396-p2gvpe8i 128 12 as as IN cord-328396-p2gvpe8i 128 13 a a DT cord-328396-p2gvpe8i 128 14 direct direct JJ cord-328396-p2gvpe8i 128 15 target target NN cord-328396-p2gvpe8i 128 16 of of IN cord-328396-p2gvpe8i 128 17 the the DT cord-328396-p2gvpe8i 128 18 virus virus NN cord-328396-p2gvpe8i 128 19 and and CC cord-328396-p2gvpe8i 128 20 inflammatory inflammatory JJ cord-328396-p2gvpe8i 128 21 cytokines cytokine NNS cord-328396-p2gvpe8i 128 22 . . . cord-328396-p2gvpe8i 129 1 Review Review NNP cord-328396-p2gvpe8i 129 2 Pons Pons NNP cord-328396-p2gvpe8i 129 3 et et NNP cord-328396-p2gvpe8i 129 4 al al NNP cord-328396-p2gvpe8i 129 5 . . NNP cord-328396-p2gvpe8i 129 6 , , , cord-328396-p2gvpe8i 130 1 2020 2020 CD cord-328396-p2gvpe8i 130 2 4 4 CD cord-328396-p2gvpe8i 130 3 . . . cord-328396-p2gvpe8i 131 1 Binding bind VBG cord-328396-p2gvpe8i 131 2 of of IN cord-328396-p2gvpe8i 131 3 virus virus NN cord-328396-p2gvpe8i 131 4 to to IN cord-328396-p2gvpe8i 131 5 ACE2-positive ace2-positive JJ cord-328396-p2gvpe8i 131 6 endothelial endothelial JJ cord-328396-p2gvpe8i 131 7 cells cell NNS cord-328396-p2gvpe8i 131 8 may may MD cord-328396-p2gvpe8i 131 9 cause cause VB cord-328396-p2gvpe8i 131 10 production production NN cord-328396-p2gvpe8i 131 11 of of IN cord-328396-p2gvpe8i 131 12 ROS ROS NNP cord-328396-p2gvpe8i 131 13 , , , cord-328396-p2gvpe8i 131 14 which which WDT cord-328396-p2gvpe8i 131 15 cause cause VBP cord-328396-p2gvpe8i 131 16 these these DT cord-328396-p2gvpe8i 131 17 cells cell NNS cord-328396-p2gvpe8i 131 18 to to TO cord-328396-p2gvpe8i 131 19 acquire acquire VB cord-328396-p2gvpe8i 131 20 a a DT cord-328396-p2gvpe8i 131 21 pro pro JJ cord-328396-p2gvpe8i 131 22 - - JJ cord-328396-p2gvpe8i 131 23 thrombotic thrombotic JJ cord-328396-p2gvpe8i 131 24 and and CC cord-328396-p2gvpe8i 131 25 pro pro JJ cord-328396-p2gvpe8i 131 26 - - JJ cord-328396-p2gvpe8i 131 27 inflammatory inflammatory JJ cord-328396-p2gvpe8i 131 28 phenotype phenotype NN cord-328396-p2gvpe8i 131 29 , , , cord-328396-p2gvpe8i 131 30 predisposing predispose VBG cord-328396-p2gvpe8i 131 31 patients patient NNS cord-328396-p2gvpe8i 131 32 to to IN cord-328396-p2gvpe8i 131 33 thromboembolic thromboembolic JJ cord-328396-p2gvpe8i 131 34 and and CC cord-328396-p2gvpe8i 131 35 vasculitic vasculitic JJ cord-328396-p2gvpe8i 131 36 events event NNS cord-328396-p2gvpe8i 131 37 and and CC cord-328396-p2gvpe8i 131 38 to to IN cord-328396-p2gvpe8i 131 39 disseminated disseminate VBN cord-328396-p2gvpe8i 131 40 intravascular intravascular JJ cord-328396-p2gvpe8i 131 41 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 131 42 . . . cord-328396-p2gvpe8i 132 1 Short Short NNP cord-328396-p2gvpe8i 132 2 Report Report NNP cord-328396-p2gvpe8i 132 3 Panfoli Panfoli NNP cord-328396-p2gvpe8i 132 4 , , , cord-328396-p2gvpe8i 132 5 2020 2020 CD cord-328396-p2gvpe8i 132 6 5 5 CD cord-328396-p2gvpe8i 132 7 . . . cord-328396-p2gvpe8i 133 1 Comparative comparative JJ cord-328396-p2gvpe8i 133 2 study study NN cord-328396-p2gvpe8i 133 3 between between IN cord-328396-p2gvpe8i 133 4 various various JJ cord-328396-p2gvpe8i 133 5 coronavirus coronavirus NN cord-328396-p2gvpe8i 133 6 reveals reveal VBZ cord-328396-p2gvpe8i 133 7 similarities similarity NNS cord-328396-p2gvpe8i 133 8 in in IN cord-328396-p2gvpe8i 133 9 entry entry NN cord-328396-p2gvpe8i 133 10 and and CC cord-328396-p2gvpe8i 133 11 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 133 12 of of IN cord-328396-p2gvpe8i 133 13 SARS SARS NNP cord-328396-p2gvpe8i 133 14 - - HYPH cord-328396-p2gvpe8i 133 15 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 133 16 along along IN cord-328396-p2gvpe8i 133 17 with with IN cord-328396-p2gvpe8i 133 18 SARS SARS NNP cord-328396-p2gvpe8i 133 19 and and CC cord-328396-p2gvpe8i 133 20 MERS MERS NNPS cord-328396-p2gvpe8i 133 21 in in IN cord-328396-p2gvpe8i 133 22 various various JJ cord-328396-p2gvpe8i 133 23 aspects aspect NNS cord-328396-p2gvpe8i 133 24 of of IN cord-328396-p2gvpe8i 133 25 multi multi JJ cord-328396-p2gvpe8i 133 26 organ organ NN cord-328396-p2gvpe8i 133 27 involvement involvement NN cord-328396-p2gvpe8i 133 28 and and CC cord-328396-p2gvpe8i 133 29 systematic systematic JJ cord-328396-p2gvpe8i 133 30 vasculitis vasculitis NN cord-328396-p2gvpe8i 133 31 along along IN cord-328396-p2gvpe8i 133 32 with with IN cord-328396-p2gvpe8i 133 33 similarities similarity NNS cord-328396-p2gvpe8i 133 34 in in IN cord-328396-p2gvpe8i 133 35 immune immune JJ cord-328396-p2gvpe8i 133 36 - - HYPH cord-328396-p2gvpe8i 133 37 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 133 38 . . . cord-328396-p2gvpe8i 134 1 The the DT cord-328396-p2gvpe8i 134 2 involvement involvement NN cord-328396-p2gvpe8i 134 3 of of IN cord-328396-p2gvpe8i 134 4 multiple multiple JJ cord-328396-p2gvpe8i 134 5 organs organ NNS cord-328396-p2gvpe8i 134 6 in in IN cord-328396-p2gvpe8i 134 7 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 134 8 indicates indicate VBZ cord-328396-p2gvpe8i 134 9 that that IN cord-328396-p2gvpe8i 134 10 endothelial endothelial JJ cord-328396-p2gvpe8i 134 11 injury injury NN cord-328396-p2gvpe8i 134 12 leading lead VBG cord-328396-p2gvpe8i 134 13 to to IN cord-328396-p2gvpe8i 134 14 visceral visceral JJ cord-328396-p2gvpe8i 134 15 vasculopathy vasculopathy NNP cord-328396-p2gvpe8i 134 16 may may MD cord-328396-p2gvpe8i 134 17 be be VB cord-328396-p2gvpe8i 134 18 the the DT cord-328396-p2gvpe8i 134 19 inciting incite VBG cord-328396-p2gvpe8i 134 20 factor factor NN cord-328396-p2gvpe8i 134 21 in in IN cord-328396-p2gvpe8i 134 22 the the DT cord-328396-p2gvpe8i 134 23 disease disease NN cord-328396-p2gvpe8i 134 24 progression progression NN cord-328396-p2gvpe8i 134 25 . . . cord-328396-p2gvpe8i 135 1 Review Review NNP cord-328396-p2gvpe8i 135 2 Mondal Mondal NNP cord-328396-p2gvpe8i 135 3 et et NNP cord-328396-p2gvpe8i 135 4 al al NNP cord-328396-p2gvpe8i 135 5 . . NNP cord-328396-p2gvpe8i 135 6 , , , cord-328396-p2gvpe8i 135 7 2020 2020 CD cord-328396-p2gvpe8i 135 8 ) ) -RRB- cord-328396-p2gvpe8i 135 9 6 6 CD cord-328396-p2gvpe8i 135 10 . . . cord-328396-p2gvpe8i 136 1 Vascular vascular JJ cord-328396-p2gvpe8i 136 2 - - HYPH cord-328396-p2gvpe8i 136 3 centric centric NN cord-328396-p2gvpe8i 136 4 pathology pathology NN cord-328396-p2gvpe8i 136 5 of of IN cord-328396-p2gvpe8i 136 6 COVID-19-induced COVID-19-induced NNP cord-328396-p2gvpe8i 136 7 ARDS ARDS NNP cord-328396-p2gvpe8i 136 8 . . . cord-328396-p2gvpe8i 137 1 Complement complement JJ cord-328396-p2gvpe8i 137 2 pathway pathway NN cord-328396-p2gvpe8i 137 3 activation activation NN cord-328396-p2gvpe8i 137 4 and and CC cord-328396-p2gvpe8i 137 5 ACE2 ACE2 NNP cord-328396-p2gvpe8i 137 6 dysregulation dysregulation NN cord-328396-p2gvpe8i 137 7 contributing contribute VBG cord-328396-p2gvpe8i 137 8 to to IN cord-328396-p2gvpe8i 137 9 vascular vascular JJ cord-328396-p2gvpe8i 137 10 injury injury NN cord-328396-p2gvpe8i 137 11 and and CC cord-328396-p2gvpe8i 137 12 thrombosis thrombosis NN cord-328396-p2gvpe8i 137 13 in in IN cord-328396-p2gvpe8i 137 14 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 137 15 . . . cord-328396-p2gvpe8i 138 1 Hypothesis hypothesis NN cord-328396-p2gvpe8i 138 2 and and CC cord-328396-p2gvpe8i 138 3 Review Review NNP cord-328396-p2gvpe8i 139 1 Mangalmurti Mangalmurti NNP cord-328396-p2gvpe8i 139 2 et et NNP cord-328396-p2gvpe8i 139 3 al al NNP cord-328396-p2gvpe8i 139 4 . . . cord-328396-p2gvpe8i 140 1 , , , cord-328396-p2gvpe8i 140 2 2020 2020 CD cord-328396-p2gvpe8i 140 3 ) ) -RRB- cord-328396-p2gvpe8i 140 4 7 7 CD cord-328396-p2gvpe8i 140 5 . . . cord-328396-p2gvpe8i 141 1 Passing pass VBG cord-328396-p2gvpe8i 141 2 of of IN cord-328396-p2gvpe8i 141 3 SARS SARS NNP cord-328396-p2gvpe8i 141 4 - - HYPH cord-328396-p2gvpe8i 141 5 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 141 6 from from IN cord-328396-p2gvpe8i 141 7 the the DT cord-328396-p2gvpe8i 141 8 respiratory respiratory JJ cord-328396-p2gvpe8i 141 9 epithelium epithelium NN cord-328396-p2gvpe8i 141 10 to to IN cord-328396-p2gvpe8i 141 11 the the DT cord-328396-p2gvpe8i 141 12 endothelium endothelium NN cord-328396-p2gvpe8i 141 13 for for IN cord-328396-p2gvpe8i 141 14 viral viral JJ cord-328396-p2gvpe8i 141 15 dissemination dissemination NN cord-328396-p2gvpe8i 141 16 . . . cord-328396-p2gvpe8i 142 1 Cytokine cytokine NN cord-328396-p2gvpe8i 142 2 - - HYPH cord-328396-p2gvpe8i 142 3 driven drive VBN cord-328396-p2gvpe8i 142 4 vascular vascular JJ cord-328396-p2gvpe8i 142 5 leak leak NN cord-328396-p2gvpe8i 142 6 in in IN cord-328396-p2gvpe8i 142 7 the the DT cord-328396-p2gvpe8i 142 8 lung lung NN cord-328396-p2gvpe8i 142 9 alveolar alveolar NN cord-328396-p2gvpe8i 142 10 - - HYPH cord-328396-p2gvpe8i 142 11 endothelial endothelial JJ cord-328396-p2gvpe8i 142 12 interface interface NN cord-328396-p2gvpe8i 142 13 promotes promote VBZ cord-328396-p2gvpe8i 142 14 acute acute JJ cord-328396-p2gvpe8i 142 15 lung lung NN cord-328396-p2gvpe8i 142 16 . . . cord-328396-p2gvpe8i 143 1 Review Review NNP cord-328396-p2gvpe8i 143 2 Gustafson Gustafson NNP cord-328396-p2gvpe8i 143 3 et et NNP cord-328396-p2gvpe8i 143 4 al al NNP cord-328396-p2gvpe8i 143 5 . . NNP cord-328396-p2gvpe8i 143 6 , , , cord-328396-p2gvpe8i 143 7 2020 2020 CD cord-328396-p2gvpe8i 143 8 8 8 CD cord-328396-p2gvpe8i 143 9 . . . cord-328396-p2gvpe8i 144 1 ACE2 ACE2 NNP cord-328396-p2gvpe8i 144 2 and and CC cord-328396-p2gvpe8i 144 3 RAS RAS NNP cord-328396-p2gvpe8i 144 4 signaling signal VBG cord-328396-p2gvpe8i 144 5 , , , cord-328396-p2gvpe8i 144 6 as as IN cord-328396-p2gvpe8i 144 7 a a DT cord-328396-p2gvpe8i 144 8 possible possible JJ cord-328396-p2gvpe8i 144 9 link link NN cord-328396-p2gvpe8i 144 10 between between IN cord-328396-p2gvpe8i 144 11 the the DT cord-328396-p2gvpe8i 144 12 pre pre JJ cord-328396-p2gvpe8i 144 13 - - JJ cord-328396-p2gvpe8i 144 14 existing existing JJ cord-328396-p2gvpe8i 144 15 endothelial endothelial JJ cord-328396-p2gvpe8i 144 16 dysfunction dysfunction NN cord-328396-p2gvpe8i 144 17 and and CC cord-328396-p2gvpe8i 144 18 SARS SARS NNP cord-328396-p2gvpe8i 144 19 - - HYPH cord-328396-p2gvpe8i 144 20 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 144 21 induced induce VBD cord-328396-p2gvpe8i 144 22 endothelial endothelial JJ cord-328396-p2gvpe8i 144 23 injury injury NN cord-328396-p2gvpe8i 144 24 in in IN cord-328396-p2gvpe8i 144 25 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 144 26 associated associated JJ cord-328396-p2gvpe8i 144 27 mortality mortality NN cord-328396-p2gvpe8i 144 28 . . . cord-328396-p2gvpe8i 145 1 Key key JJ cord-328396-p2gvpe8i 145 2 roles role NNS cord-328396-p2gvpe8i 145 3 of of IN cord-328396-p2gvpe8i 145 4 endothelial endothelial JJ cord-328396-p2gvpe8i 145 5 cell cell NN cord-328396-p2gvpe8i 145 6 - - HYPH cord-328396-p2gvpe8i 145 7 expressed express VBN cord-328396-p2gvpe8i 145 8 cell cell NN cord-328396-p2gvpe8i 145 9 adhesion adhesion NN cord-328396-p2gvpe8i 145 10 molecules molecule NNS cord-328396-p2gvpe8i 145 11 including include VBG cord-328396-p2gvpe8i 145 12 CD209L CD209L NNP cord-328396-p2gvpe8i 145 13 / / SYM cord-328396-p2gvpe8i 145 14 L l NN cord-328396-p2gvpe8i 145 15 - - HYPH cord-328396-p2gvpe8i 145 16 SIGN sign NN cord-328396-p2gvpe8i 145 17 and and CC cord-328396-p2gvpe8i 145 18 CD209 CD209 NNP cord-328396-p2gvpe8i 145 19 / / SYM cord-328396-p2gvpe8i 145 20 DC DC NNP cord-328396-p2gvpe8i 145 21 - - HYPH cord-328396-p2gvpe8i 145 22 SIGN SIGN NNP cord-328396-p2gvpe8i 145 23 in in IN cord-328396-p2gvpe8i 145 24 SARS SARS NNP cord-328396-p2gvpe8i 145 25 - - HYPH cord-328396-p2gvpe8i 145 26 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 145 27 infection infection NN cord-328396-p2gvpe8i 145 28 . . . cord-328396-p2gvpe8i 146 1 Amraei Amraei NNP cord-328396-p2gvpe8i 146 2 and and CC cord-328396-p2gvpe8i 146 3 Rahimi Rahimi NNP cord-328396-p2gvpe8i 146 4 , , , cord-328396-p2gvpe8i 146 5 2020 2020 CD cord-328396-p2gvpe8i 146 6 9 9 CD cord-328396-p2gvpe8i 146 7 . . . cord-328396-p2gvpe8i 147 1 Serum Serum NNP cord-328396-p2gvpe8i 147 2 Angiotensin Angiotensin NNP cord-328396-p2gvpe8i 147 3 II ii CD cord-328396-p2gvpe8i 147 4 levels level NNS cord-328396-p2gvpe8i 147 5 are be VBP cord-328396-p2gvpe8i 147 6 increased increase VBN cord-328396-p2gvpe8i 147 7 with with IN cord-328396-p2gvpe8i 147 8 ACE2 ACE2 NNP cord-328396-p2gvpe8i 147 9 blocking blocking NN cord-328396-p2gvpe8i 147 10 by by IN cord-328396-p2gvpe8i 147 11 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 147 12 . . . cord-328396-p2gvpe8i 148 1 Angiotensin angiotensin NN cord-328396-p2gvpe8i 148 2 II ii CD cord-328396-p2gvpe8i 148 3 stimulation stimulation NN cord-328396-p2gvpe8i 148 4 and and CC cord-328396-p2gvpe8i 148 5 local local JJ cord-328396-p2gvpe8i 148 6 stimuli stimulus NNS cord-328396-p2gvpe8i 148 7 such such JJ cord-328396-p2gvpe8i 148 8 as as IN cord-328396-p2gvpe8i 148 9 H h NN cord-328396-p2gvpe8i 148 10 + + CC cord-328396-p2gvpe8i 148 11 ion ion NN cord-328396-p2gvpe8i 148 12 and and CC cord-328396-p2gvpe8i 148 13 hypoxia hypoxia NN cord-328396-p2gvpe8i 148 14 activate activate VB cord-328396-p2gvpe8i 148 15 Na Na NNP cord-328396-p2gvpe8i 148 16 + + SYM cord-328396-p2gvpe8i 148 17 /H /H NNS cord-328396-p2gvpe8i 148 18 + + CC cord-328396-p2gvpe8i 148 19 exchanger exchanger NN cord-328396-p2gvpe8i 148 20 ( ( -LRB- cord-328396-p2gvpe8i 148 21 NHE NHE NNP cord-328396-p2gvpe8i 148 22 ) ) -RRB- cord-328396-p2gvpe8i 148 23 in in IN cord-328396-p2gvpe8i 148 24 both both DT cord-328396-p2gvpe8i 148 25 vascular vascular JJ cord-328396-p2gvpe8i 148 26 endothelium endothelium NN cord-328396-p2gvpe8i 148 27 and and CC cord-328396-p2gvpe8i 148 28 platelets platelet NNS cord-328396-p2gvpe8i 148 29 . . . cord-328396-p2gvpe8i 149 1 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 149 2 can can MD cord-328396-p2gvpe8i 149 3 lead lead VB cord-328396-p2gvpe8i 149 4 to to IN cord-328396-p2gvpe8i 149 5 thrombosis thrombosis NN cord-328396-p2gvpe8i 149 6 by by IN cord-328396-p2gvpe8i 149 7 causing cause VBG cord-328396-p2gvpe8i 149 8 NHE NHE NNP cord-328396-p2gvpe8i 149 9 activation activation NN cord-328396-p2gvpe8i 149 10 . . . cord-328396-p2gvpe8i 150 1 Letter letter NN cord-328396-p2gvpe8i 150 2 Cure cure NN cord-328396-p2gvpe8i 150 3 and and CC cord-328396-p2gvpe8i 150 4 Cure cure NN cord-328396-p2gvpe8i 150 5 , , , cord-328396-p2gvpe8i 150 6 2020 2020 CD cord-328396-p2gvpe8i 150 7 ) ) -RRB- cord-328396-p2gvpe8i 150 8 10 10 CD cord-328396-p2gvpe8i 150 9 . . . cord-328396-p2gvpe8i 151 1 Apoptotic apoptotic JJ cord-328396-p2gvpe8i 151 2 processes process NNS cord-328396-p2gvpe8i 151 3 in in IN cord-328396-p2gvpe8i 151 4 the the DT cord-328396-p2gvpe8i 151 5 ACE2-positive ace2-positive JJ cord-328396-p2gvpe8i 151 6 lung lung NN cord-328396-p2gvpe8i 151 7 microvascular microvascular NN cord-328396-p2gvpe8i 151 8 bed bed NN cord-328396-p2gvpe8i 151 9 endothelium endothelium NN cord-328396-p2gvpe8i 151 10 or or CC cord-328396-p2gvpe8i 151 11 coronary coronary JJ cord-328396-p2gvpe8i 151 12 endothelium endothelium NN cord-328396-p2gvpe8i 151 13 by by IN cord-328396-p2gvpe8i 151 14 SARS SARS NNP cord-328396-p2gvpe8i 151 15 - - HYPH cord-328396-p2gvpe8i 151 16 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 151 17 . . . cord-328396-p2gvpe8i 152 1 Increased increase VBN cord-328396-p2gvpe8i 152 2 D d NN cord-328396-p2gvpe8i 152 3 - - HYPH cord-328396-p2gvpe8i 152 4 dimer dimer NN cord-328396-p2gvpe8i 152 5 may may MD cord-328396-p2gvpe8i 152 6 be be VB cord-328396-p2gvpe8i 152 7 the the DT cord-328396-p2gvpe8i 152 8 result result NN cord-328396-p2gvpe8i 152 9 of of IN cord-328396-p2gvpe8i 152 10 apoptotic apoptotic JJ cord-328396-p2gvpe8i 152 11 endothelial endothelial JJ cord-328396-p2gvpe8i 152 12 cell cell NN cord-328396-p2gvpe8i 152 13 induced induce VBN cord-328396-p2gvpe8i 152 14 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 152 15 . . . cord-328396-p2gvpe8i 153 1 Letter Letter NNP cord-328396-p2gvpe8i 153 2 Guler Guler NNP cord-328396-p2gvpe8i 153 3 et et NNP cord-328396-p2gvpe8i 153 4 al al NNP cord-328396-p2gvpe8i 153 5 . . NNP cord-328396-p2gvpe8i 153 6 , , , cord-328396-p2gvpe8i 153 7 2020 2020 CD cord-328396-p2gvpe8i 153 8 11 11 CD cord-328396-p2gvpe8i 153 9 . . . cord-328396-p2gvpe8i 154 1 Endothelial endothelial JJ cord-328396-p2gvpe8i 154 2 damage damage NN cord-328396-p2gvpe8i 154 3 mediated mediate VBN cord-328396-p2gvpe8i 154 4 by by IN cord-328396-p2gvpe8i 154 5 complement complement JJ cord-328396-p2gvpe8i 154 6 activation activation NN cord-328396-p2gvpe8i 154 7 , , , cord-328396-p2gvpe8i 154 8 inflammation inflammation NN cord-328396-p2gvpe8i 154 9 , , , cord-328396-p2gvpe8i 154 10 hypoxia hypoxia NN cord-328396-p2gvpe8i 154 11 , , , cord-328396-p2gvpe8i 154 12 platelets platelet NNS cord-328396-p2gvpe8i 154 13 , , , cord-328396-p2gvpe8i 154 14 and and CC cord-328396-p2gvpe8i 154 15 ABL ABL NNP cord-328396-p2gvpe8i 154 16 tyrosine tyrosine NN cord-328396-p2gvpe8i 154 17 kinases kinase NNS cord-328396-p2gvpe8i 154 18 as as IN cord-328396-p2gvpe8i 154 19 relevant relevant JJ cord-328396-p2gvpe8i 154 20 cause cause NN cord-328396-p2gvpe8i 154 21 of of IN cord-328396-p2gvpe8i 154 22 death death NN cord-328396-p2gvpe8i 154 23 in in IN cord-328396-p2gvpe8i 154 24 patients patient NNS cord-328396-p2gvpe8i 154 25 with with IN cord-328396-p2gvpe8i 154 26 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 154 27 . . . cord-328396-p2gvpe8i 155 1 Review Review NNP cord-328396-p2gvpe8i 155 2 Marchetti Marchetti NNP cord-328396-p2gvpe8i 155 3 , , , cord-328396-p2gvpe8i 155 4 2020 2020 CD cord-328396-p2gvpe8i 155 5 ) ) -RRB- cord-328396-p2gvpe8i 155 6 12 12 CD cord-328396-p2gvpe8i 155 7 . . . cord-328396-p2gvpe8i 156 1 Endothelial endothelial JJ cord-328396-p2gvpe8i 156 2 cells cell NNS cord-328396-p2gvpe8i 156 3 play play VBP cord-328396-p2gvpe8i 156 4 a a DT cord-328396-p2gvpe8i 156 5 central central JJ cord-328396-p2gvpe8i 156 6 role role NN cord-328396-p2gvpe8i 156 7 in in IN cord-328396-p2gvpe8i 156 8 the the DT cord-328396-p2gvpe8i 156 9 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 156 10 of of IN cord-328396-p2gvpe8i 156 11 ARDS ARDS NNP cord-328396-p2gvpe8i 156 12 and and CC cord-328396-p2gvpe8i 156 13 multi multi JJ cord-328396-p2gvpe8i 156 14 - - JJ cord-328396-p2gvpe8i 156 15 organ organ JJ cord-328396-p2gvpe8i 156 16 failure failure NN cord-328396-p2gvpe8i 156 17 in in IN cord-328396-p2gvpe8i 156 18 patients patient NNS cord-328396-p2gvpe8i 156 19 with with IN cord-328396-p2gvpe8i 156 20 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 156 21 . . . cord-328396-p2gvpe8i 157 1 Review Review NNP cord-328396-p2gvpe8i 157 2 Teuwen Teuwen NNP cord-328396-p2gvpe8i 157 3 et et NNP cord-328396-p2gvpe8i 157 4 al al NNP cord-328396-p2gvpe8i 157 5 . . NNP cord-328396-p2gvpe8i 157 6 , , , cord-328396-p2gvpe8i 157 7 2020 2020 CD cord-328396-p2gvpe8i 157 8 13 13 CD cord-328396-p2gvpe8i 157 9 . . . cord-328396-p2gvpe8i 158 1 Increased increase VBN cord-328396-p2gvpe8i 158 2 mortality mortality NN cord-328396-p2gvpe8i 158 3 in in IN cord-328396-p2gvpe8i 158 4 young young JJ cord-328396-p2gvpe8i 158 5 males male NNS cord-328396-p2gvpe8i 158 6 in in IN cord-328396-p2gvpe8i 158 7 Italy Italy NNP cord-328396-p2gvpe8i 158 8 linked link VBD cord-328396-p2gvpe8i 158 9 to to IN cord-328396-p2gvpe8i 158 10 the the DT cord-328396-p2gvpe8i 158 11 diversity diversity NN cord-328396-p2gvpe8i 158 12 in in IN cord-328396-p2gvpe8i 158 13 sex sex NN cord-328396-p2gvpe8i 158 14 - - HYPH cord-328396-p2gvpe8i 158 15 hormones hormone NNS cord-328396-p2gvpe8i 158 16 . . . cord-328396-p2gvpe8i 159 1 Activation activation NN cord-328396-p2gvpe8i 159 2 of of IN cord-328396-p2gvpe8i 159 3 endothelial endothelial JJ cord-328396-p2gvpe8i 159 4 estrogen estrogen NN cord-328396-p2gvpe8i 159 5 receptors receptor NNS cord-328396-p2gvpe8i 159 6 increases increase VBZ cord-328396-p2gvpe8i 159 7 nitric nitric JJ cord-328396-p2gvpe8i 159 8 oxide oxide NN cord-328396-p2gvpe8i 159 9 and and CC cord-328396-p2gvpe8i 159 10 decreases decrease VBZ cord-328396-p2gvpe8i 159 11 ROS ROS NNP cord-328396-p2gvpe8i 159 12 , , , cord-328396-p2gvpe8i 159 13 protecting protect VBG cord-328396-p2gvpe8i 159 14 the the DT cord-328396-p2gvpe8i 159 15 vascular vascular JJ cord-328396-p2gvpe8i 159 16 system system NN cord-328396-p2gvpe8i 159 17 of of IN cord-328396-p2gvpe8i 159 18 females female NNS cord-328396-p2gvpe8i 159 19 from from IN cord-328396-p2gvpe8i 159 20 angiotensin angiotensin NN cord-328396-p2gvpe8i 159 21 II II NNP cord-328396-p2gvpe8i 159 22 - - HYPH cord-328396-p2gvpe8i 159 23 mediated mediate VBN cord-328396-p2gvpe8i 159 24 vasoconstriction vasoconstriction NN cord-328396-p2gvpe8i 159 25 , , , cord-328396-p2gvpe8i 159 26 inflammation inflammation NN cord-328396-p2gvpe8i 159 27 , , , cord-328396-p2gvpe8i 159 28 and and CC cord-328396-p2gvpe8i 159 29 ROS ROS NNP cord-328396-p2gvpe8i 159 30 production production NN cord-328396-p2gvpe8i 159 31 . . . cord-328396-p2gvpe8i 160 1 Hypothesis hypothesis NN cord-328396-p2gvpe8i 160 2 Froldi Froldi NNP cord-328396-p2gvpe8i 160 3 and and CC cord-328396-p2gvpe8i 160 4 Dorigo Dorigo NNP cord-328396-p2gvpe8i 160 5 , , , cord-328396-p2gvpe8i 160 6 2020 2020 CD cord-328396-p2gvpe8i 160 7 ) ) -RRB- cord-328396-p2gvpe8i 160 8 14 14 CD cord-328396-p2gvpe8i 160 9 . . . cord-328396-p2gvpe8i 161 1 Extrapulmonary extrapulmonary JJ cord-328396-p2gvpe8i 161 2 organ organ NN cord-328396-p2gvpe8i 161 3 - - HYPH cord-328396-p2gvpe8i 161 4 specific specific JJ cord-328396-p2gvpe8i 161 5 pathophysiology pathophysiology NN cord-328396-p2gvpe8i 161 6 and and CC cord-328396-p2gvpe8i 161 7 clinical clinical JJ cord-328396-p2gvpe8i 161 8 presentation presentation NN cord-328396-p2gvpe8i 161 9 of of IN cord-328396-p2gvpe8i 161 10 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 161 11 . . . cord-328396-p2gvpe8i 162 1 Central central JJ cord-328396-p2gvpe8i 162 2 role role NN cord-328396-p2gvpe8i 162 3 of of IN cord-328396-p2gvpe8i 162 4 endothelial endothelial JJ cord-328396-p2gvpe8i 162 5 damage damage NN cord-328396-p2gvpe8i 162 6 and and CC cord-328396-p2gvpe8i 162 7 thrombo thrombo NN cord-328396-p2gvpe8i 162 8 - - HYPH cord-328396-p2gvpe8i 162 9 inflammation inflammation NN cord-328396-p2gvpe8i 162 10 . . . cord-328396-p2gvpe8i 163 1 Review Review NNP cord-328396-p2gvpe8i 163 2 Gupta Gupta NNP cord-328396-p2gvpe8i 163 3 et et NNP cord-328396-p2gvpe8i 163 4 al al NNP cord-328396-p2gvpe8i 163 5 . . NNP cord-328396-p2gvpe8i 163 6 , , , cord-328396-p2gvpe8i 164 1 2020 2020 CD cord-328396-p2gvpe8i 165 1 ROS ROS NNP cord-328396-p2gvpe8i 165 2 , , , cord-328396-p2gvpe8i 165 3 reactive reactive JJ cord-328396-p2gvpe8i 165 4 oxygen oxygen NN cord-328396-p2gvpe8i 165 5 species specie NNS cord-328396-p2gvpe8i 165 6 ; ; : cord-328396-p2gvpe8i 165 7 ACE2 ACE2 NNP cord-328396-p2gvpe8i 165 8 , , , cord-328396-p2gvpe8i 165 9 angiotensin angiotensin NN cord-328396-p2gvpe8i 165 10 converting convert VBG cord-328396-p2gvpe8i 165 11 enzyme2 enzyme2 NN cord-328396-p2gvpe8i 165 12 ; ; : cord-328396-p2gvpe8i 165 13 ARDS ARDS NNP cord-328396-p2gvpe8i 165 14 , , , cord-328396-p2gvpe8i 165 15 acute acute JJ cord-328396-p2gvpe8i 165 16 respiratory respiratory JJ cord-328396-p2gvpe8i 165 17 distress distress NN cord-328396-p2gvpe8i 165 18 syndrome syndrome NN cord-328396-p2gvpe8i 165 19 . . . cord-328396-p2gvpe8i 166 1 An an DT cord-328396-p2gvpe8i 166 2 evaluation evaluation NN cord-328396-p2gvpe8i 166 3 of of IN cord-328396-p2gvpe8i 166 4 angiogenic angiogenic JJ cord-328396-p2gvpe8i 166 5 factors factor NNS cord-328396-p2gvpe8i 166 6 and and CC cord-328396-p2gvpe8i 166 7 their -PRON- PRP$ cord-328396-p2gvpe8i 166 8 soluble soluble JJ cord-328396-p2gvpe8i 166 9 receptors receptor NNS cord-328396-p2gvpe8i 166 10 , , , cord-328396-p2gvpe8i 166 11 particularly particularly RB cord-328396-p2gvpe8i 166 12 sVEGFR2 sVEGFR2 NNP cord-328396-p2gvpe8i 166 13 and and CC cord-328396-p2gvpe8i 166 14 Angiopoetin-2 Angiopoetin-2 NNP cord-328396-p2gvpe8i 166 15 , , , cord-328396-p2gvpe8i 166 16 might may MD cord-328396-p2gvpe8i 166 17 be be VB cord-328396-p2gvpe8i 166 18 of of IN cord-328396-p2gvpe8i 166 19 prognostic prognostic JJ cord-328396-p2gvpe8i 166 20 significance significance NN cord-328396-p2gvpe8i 166 21 in in IN cord-328396-p2gvpe8i 166 22 these these DT cord-328396-p2gvpe8i 166 23 patients patient NNS cord-328396-p2gvpe8i 166 24 . . . cord-328396-p2gvpe8i 167 1 Circulating circulate VBG cord-328396-p2gvpe8i 167 2 endothelial endothelial JJ cord-328396-p2gvpe8i 167 3 progenitor progenitor NN cord-328396-p2gvpe8i 167 4 cells cell NNS cord-328396-p2gvpe8i 167 5 ( ( -LRB- cord-328396-p2gvpe8i 167 6 EPCs epc NNS cord-328396-p2gvpe8i 167 7 ) ) -RRB- cord-328396-p2gvpe8i 167 8 may may MD cord-328396-p2gvpe8i 167 9 also also RB cord-328396-p2gvpe8i 167 10 be be VB cord-328396-p2gvpe8i 167 11 used use VBN cord-328396-p2gvpe8i 167 12 to to TO cord-328396-p2gvpe8i 167 13 assess assess VB cord-328396-p2gvpe8i 167 14 / / SYM cord-328396-p2gvpe8i 167 15 predict predict VB cord-328396-p2gvpe8i 167 16 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 167 17 disease disease NN cord-328396-p2gvpe8i 167 18 severity severity NN cord-328396-p2gvpe8i 167 19 and and CC cord-328396-p2gvpe8i 167 20 progression progression NN cord-328396-p2gvpe8i 167 21 in in IN cord-328396-p2gvpe8i 167 22 longitudinal longitudinal JJ cord-328396-p2gvpe8i 167 23 studies study NNS cord-328396-p2gvpe8i 167 24 as as IN cord-328396-p2gvpe8i 167 25 altered alter VBN cord-328396-p2gvpe8i 167 26 levels level NNS cord-328396-p2gvpe8i 167 27 of of IN cord-328396-p2gvpe8i 167 28 EPCs epc NNS cord-328396-p2gvpe8i 167 29 have have VBP cord-328396-p2gvpe8i 167 30 been be VBN cord-328396-p2gvpe8i 167 31 demonstrated demonstrate VBN cord-328396-p2gvpe8i 167 32 in in IN cord-328396-p2gvpe8i 167 33 patients patient NNS cord-328396-p2gvpe8i 167 34 with with IN cord-328396-p2gvpe8i 167 35 both both DT cord-328396-p2gvpe8i 167 36 acute acute JJ cord-328396-p2gvpe8i 167 37 lung lung NN cord-328396-p2gvpe8i 167 38 injury injury NN cord-328396-p2gvpe8i 167 39 and and CC cord-328396-p2gvpe8i 167 40 bacterial bacterial JJ cord-328396-p2gvpe8i 167 41 sepsis sepsis NN cord-328396-p2gvpe8i 168 1 ( ( -LRB- cord-328396-p2gvpe8i 168 2 Witzenrath Witzenrath NNP cord-328396-p2gvpe8i 168 3 , , , cord-328396-p2gvpe8i 168 4 2014 2014 CD cord-328396-p2gvpe8i 168 5 ) ) -RRB- cord-328396-p2gvpe8i 168 6 . . . cord-328396-p2gvpe8i 169 1 Identification identification NN cord-328396-p2gvpe8i 169 2 of of IN cord-328396-p2gvpe8i 169 3 biomarkers biomarker NNS cord-328396-p2gvpe8i 169 4 and and CC cord-328396-p2gvpe8i 169 5 molecular molecular JJ cord-328396-p2gvpe8i 169 6 mechanisms mechanism NNS cord-328396-p2gvpe8i 169 7 underlying underlie VBG cord-328396-p2gvpe8i 169 8 COVID-19-induced covid-19-induced JJ cord-328396-p2gvpe8i 169 9 endothelial endothelial JJ cord-328396-p2gvpe8i 169 10 injury injury NN cord-328396-p2gvpe8i 169 11 should should MD cord-328396-p2gvpe8i 169 12 lead lead VB cord-328396-p2gvpe8i 169 13 to to IN cord-328396-p2gvpe8i 169 14 new new JJ cord-328396-p2gvpe8i 169 15 pharmacological pharmacological JJ cord-328396-p2gvpe8i 169 16 targets target NNS cord-328396-p2gvpe8i 169 17 to to TO cord-328396-p2gvpe8i 169 18 ameliorate ameliorate VB cord-328396-p2gvpe8i 169 19 several several JJ cord-328396-p2gvpe8i 169 20 processes process NNS cord-328396-p2gvpe8i 169 21 starting start VBG cord-328396-p2gvpe8i 169 22 from from IN cord-328396-p2gvpe8i 169 23 vascular vascular JJ cord-328396-p2gvpe8i 169 24 permeability permeability NN cord-328396-p2gvpe8i 169 25 to to IN cord-328396-p2gvpe8i 169 26 neutrophil neutrophil NN cord-328396-p2gvpe8i 169 27 accumulation accumulation NN cord-328396-p2gvpe8i 169 28 , , , cord-328396-p2gvpe8i 169 29 angiogenesis angiogenesis NN cord-328396-p2gvpe8i 169 30 , , , cord-328396-p2gvpe8i 169 31 pro pro JJ cord-328396-p2gvpe8i 169 32 - - JJ cord-328396-p2gvpe8i 169 33 coagulation coagulation JJ cord-328396-p2gvpe8i 169 34 toV tov NN cord-328396-p2gvpe8i 169 35 / / SYM cord-328396-p2gvpe8i 169 36 Q q NN cord-328396-p2gvpe8i 169 37 mismatching mismatching NN cord-328396-p2gvpe8i 169 38 in in IN cord-328396-p2gvpe8i 169 39 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 169 40 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 169 41 . . . cord-328396-p2gvpe8i 170 1 Meanwhile meanwhile RB cord-328396-p2gvpe8i 170 2 , , , cord-328396-p2gvpe8i 170 3 a a DT cord-328396-p2gvpe8i 170 4 variety variety NN cord-328396-p2gvpe8i 170 5 of of IN cord-328396-p2gvpe8i 170 6 currently currently RB cord-328396-p2gvpe8i 170 7 used use VBN cord-328396-p2gvpe8i 170 8 or or CC cord-328396-p2gvpe8i 170 9 investigational investigational JJ cord-328396-p2gvpe8i 170 10 drugs drug NNS cord-328396-p2gvpe8i 170 11 such such JJ cord-328396-p2gvpe8i 170 12 as as IN cord-328396-p2gvpe8i 170 13 statins statin NNS cord-328396-p2gvpe8i 170 14 , , , cord-328396-p2gvpe8i 170 15 tyrosine tyrosine NN cord-328396-p2gvpe8i 170 16 kinase kinase NN cord-328396-p2gvpe8i 170 17 inhibitors inhibitor NNS cord-328396-p2gvpe8i 170 18 , , , cord-328396-p2gvpe8i 170 19 atrial atrial JJ cord-328396-p2gvpe8i 170 20 natriuretic natriuretic JJ cord-328396-p2gvpe8i 170 21 peptide peptide NN cord-328396-p2gvpe8i 170 22 , , , cord-328396-p2gvpe8i 170 23 S1P s1p NN cord-328396-p2gvpe8i 170 24 1 1 CD cord-328396-p2gvpe8i 170 25 agonists agonist NNS cord-328396-p2gvpe8i 170 26 that that WDT cord-328396-p2gvpe8i 170 27 exert exert VBP cord-328396-p2gvpe8i 170 28 endothelial endothelial JJ cord-328396-p2gvpe8i 170 29 protective protective JJ cord-328396-p2gvpe8i 170 30 or or CC cord-328396-p2gvpe8i 170 31 repair repair NN cord-328396-p2gvpe8i 170 32 effects effect NNS cord-328396-p2gvpe8i 170 33 may may MD cord-328396-p2gvpe8i 170 34 be be VB cord-328396-p2gvpe8i 170 35 explored explore VBN cord-328396-p2gvpe8i 170 36 for for IN cord-328396-p2gvpe8i 170 37 their -PRON- PRP$ cord-328396-p2gvpe8i 170 38 effects effect NNS cord-328396-p2gvpe8i 170 39 in in IN cord-328396-p2gvpe8i 170 40 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 170 41 . . . cord-328396-p2gvpe8i 171 1 Dexamethasone Dexamethasone NNP cord-328396-p2gvpe8i 171 2 , , , cord-328396-p2gvpe8i 171 3 a a DT cord-328396-p2gvpe8i 171 4 synthetic synthetic JJ cord-328396-p2gvpe8i 171 5 corticosteroid corticosteroid NN cord-328396-p2gvpe8i 171 6 and and CC cord-328396-p2gvpe8i 171 7 other other JJ cord-328396-p2gvpe8i 171 8 anti anti JJ cord-328396-p2gvpe8i 171 9 - - JJ cord-328396-p2gvpe8i 171 10 inflammatory inflammatory JJ cord-328396-p2gvpe8i 171 11 drugs drug NNS cord-328396-p2gvpe8i 171 12 that that WDT cord-328396-p2gvpe8i 171 13 are be VBP cord-328396-p2gvpe8i 171 14 already already RB cord-328396-p2gvpe8i 171 15 used use VBN cord-328396-p2gvpe8i 171 16 in in IN cord-328396-p2gvpe8i 171 17 many many JJ cord-328396-p2gvpe8i 171 18 inflammatory inflammatory JJ cord-328396-p2gvpe8i 171 19 diseases disease NNS cord-328396-p2gvpe8i 171 20 including include VBG cord-328396-p2gvpe8i 171 21 sepsis sepsis NN cord-328396-p2gvpe8i 171 22 and and CC cord-328396-p2gvpe8i 171 23 ARDS ARDS NNP cord-328396-p2gvpe8i 171 24 seem seem VBP cord-328396-p2gvpe8i 171 25 to to TO cord-328396-p2gvpe8i 171 26 be be VB cord-328396-p2gvpe8i 171 27 a a DT cord-328396-p2gvpe8i 171 28 ray ray NN cord-328396-p2gvpe8i 171 29 of of IN cord-328396-p2gvpe8i 171 30 hope hope NN cord-328396-p2gvpe8i 171 31 in in IN cord-328396-p2gvpe8i 171 32 mitigating mitigate VBG cord-328396-p2gvpe8i 171 33 mortality mortality NN cord-328396-p2gvpe8i 171 34 in in IN cord-328396-p2gvpe8i 171 35 critically critically RB cord-328396-p2gvpe8i 171 36 ill ill JJ cord-328396-p2gvpe8i 171 37 patients patient NNS cord-328396-p2gvpe8i 171 38 of of IN cord-328396-p2gvpe8i 171 39 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 171 40 ( ( -LRB- cord-328396-p2gvpe8i 171 41 Ledford Ledford NNP cord-328396-p2gvpe8i 171 42 , , , cord-328396-p2gvpe8i 171 43 2020 2020 CD cord-328396-p2gvpe8i 171 44 ) ) -RRB- cord-328396-p2gvpe8i 171 45 . . . cord-328396-p2gvpe8i 172 1 Dexamethasone Dexamethasone NNP cord-328396-p2gvpe8i 172 2 and and CC cord-328396-p2gvpe8i 172 3 other other JJ cord-328396-p2gvpe8i 172 4 steroids steroid NNS cord-328396-p2gvpe8i 172 5 are be VBP cord-328396-p2gvpe8i 172 6 also also RB cord-328396-p2gvpe8i 172 7 known know VBN cord-328396-p2gvpe8i 172 8 to to TO cord-328396-p2gvpe8i 172 9 inhibit inhibit VB cord-328396-p2gvpe8i 172 10 endothelial endothelial JJ cord-328396-p2gvpe8i 172 11 activation activation NN cord-328396-p2gvpe8i 172 12 and and CC cord-328396-p2gvpe8i 172 13 levels level NNS cord-328396-p2gvpe8i 172 14 of of IN cord-328396-p2gvpe8i 172 15 soluble soluble JJ cord-328396-p2gvpe8i 172 16 VCAM1 vcam1 NN cord-328396-p2gvpe8i 172 17 and and CC cord-328396-p2gvpe8i 172 18 E E NNS cord-328396-p2gvpe8i 172 19 - - NN cord-328396-p2gvpe8i 172 20 selectins selectin NNS cord-328396-p2gvpe8i 172 21 in in IN cord-328396-p2gvpe8i 172 22 both both DT cord-328396-p2gvpe8i 172 23 in in IN cord-328396-p2gvpe8i 172 24 vitro vitro FW cord-328396-p2gvpe8i 172 25 and and CC cord-328396-p2gvpe8i 172 26 in in IN cord-328396-p2gvpe8i 172 27 vivo vivo NN cord-328396-p2gvpe8i 172 28 models model NNS cord-328396-p2gvpe8i 172 29 of of IN cord-328396-p2gvpe8i 172 30 sepsis sepsis NN cord-328396-p2gvpe8i 173 1 ( ( -LRB- cord-328396-p2gvpe8i 173 2 Zielińska Zielińska NNP cord-328396-p2gvpe8i 173 3 et et NNP cord-328396-p2gvpe8i 173 4 al al NNP cord-328396-p2gvpe8i 173 5 . . NNP cord-328396-p2gvpe8i 173 6 , , , cord-328396-p2gvpe8i 173 7 2016 2016 CD cord-328396-p2gvpe8i 173 8 ) ) -RRB- cord-328396-p2gvpe8i 173 9 . . . cord-328396-p2gvpe8i 174 1 The the DT cord-328396-p2gvpe8i 174 2 precise precise JJ cord-328396-p2gvpe8i 174 3 effects effect NNS cord-328396-p2gvpe8i 174 4 of of IN cord-328396-p2gvpe8i 174 5 steroid steroid NN cord-328396-p2gvpe8i 174 6 treatment treatment NN cord-328396-p2gvpe8i 174 7 on on IN cord-328396-p2gvpe8i 174 8 endothelial endothelial JJ cord-328396-p2gvpe8i 174 9 function function NN cord-328396-p2gvpe8i 174 10 in in IN cord-328396-p2gvpe8i 174 11 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 174 12 patients patient NNS cord-328396-p2gvpe8i 174 13 with with IN cord-328396-p2gvpe8i 174 14 varying vary VBG cord-328396-p2gvpe8i 174 15 severity severity NN cord-328396-p2gvpe8i 174 16 thus thus RB cord-328396-p2gvpe8i 174 17 warrant warrant VBP cord-328396-p2gvpe8i 174 18 in in IN cord-328396-p2gvpe8i 174 19 - - HYPH cord-328396-p2gvpe8i 174 20 depth depth NN cord-328396-p2gvpe8i 174 21 investigations investigation NNS cord-328396-p2gvpe8i 174 22 . . . cord-328396-p2gvpe8i 175 1 To to TO cord-328396-p2gvpe8i 175 2 summarize summarize VB cord-328396-p2gvpe8i 175 3 , , , cord-328396-p2gvpe8i 175 4 the the DT cord-328396-p2gvpe8i 175 5 pulmonary pulmonary JJ cord-328396-p2gvpe8i 175 6 endothelium endothelium NN cord-328396-p2gvpe8i 175 7 seems seem VBZ cord-328396-p2gvpe8i 175 8 to to TO cord-328396-p2gvpe8i 175 9 be be VB cord-328396-p2gvpe8i 175 10 standing stand VBG cord-328396-p2gvpe8i 175 11 at at IN cord-328396-p2gvpe8i 175 12 the the DT cord-328396-p2gvpe8i 175 13 crossroads crossroad NNS cord-328396-p2gvpe8i 175 14 of of IN cord-328396-p2gvpe8i 175 15 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 175 16 , , , cord-328396-p2gvpe8i 175 17 forming form VBG cord-328396-p2gvpe8i 175 18 the the DT cord-328396-p2gvpe8i 175 19 very very JJ cord-328396-p2gvpe8i 175 20 crux crux NN cord-328396-p2gvpe8i 175 21 of of IN cord-328396-p2gvpe8i 175 22 this this DT cord-328396-p2gvpe8i 175 23 baffling baffling JJ cord-328396-p2gvpe8i 175 24 disease disease NN cord-328396-p2gvpe8i 175 25 . . . cord-328396-p2gvpe8i 176 1 Endothelial endothelial JJ cord-328396-p2gvpe8i 176 2 dysfunction dysfunction NN cord-328396-p2gvpe8i 176 3 may may MD cord-328396-p2gvpe8i 176 4 be be VB cord-328396-p2gvpe8i 176 5 both both CC cord-328396-p2gvpe8i 176 6 a a DT cord-328396-p2gvpe8i 176 7 cause cause NN cord-328396-p2gvpe8i 176 8 and/or and/or CC cord-328396-p2gvpe8i 176 9 effect effect NN cord-328396-p2gvpe8i 176 10 of of IN cord-328396-p2gvpe8i 176 11 severe severe JJ cord-328396-p2gvpe8i 176 12 COVID-19 covid-19 NN cord-328396-p2gvpe8i 176 13 . . . cord-328396-p2gvpe8i 177 1 It -PRON- PRP cord-328396-p2gvpe8i 177 2 is be VBZ cord-328396-p2gvpe8i 177 3 thus thus RB cord-328396-p2gvpe8i 177 4 imperative imperative JJ cord-328396-p2gvpe8i 177 5 to to TO cord-328396-p2gvpe8i 177 6 have have VB cord-328396-p2gvpe8i 177 7 further further JJ cord-328396-p2gvpe8i 177 8 insights insight NNS cord-328396-p2gvpe8i 177 9 into into IN cord-328396-p2gvpe8i 177 10 this this DT cord-328396-p2gvpe8i 177 11 entity entity NN cord-328396-p2gvpe8i 177 12 to to TO cord-328396-p2gvpe8i 177 13 embark embark VB cord-328396-p2gvpe8i 177 14 upon upon IN cord-328396-p2gvpe8i 177 15 newer new JJR cord-328396-p2gvpe8i 177 16 prognostic prognostic JJ cord-328396-p2gvpe8i 177 17 markers marker NNS cord-328396-p2gvpe8i 177 18 and and CC cord-328396-p2gvpe8i 177 19 effective effective JJ cord-328396-p2gvpe8i 177 20 treatment treatment NN cord-328396-p2gvpe8i 177 21 options option NNS cord-328396-p2gvpe8i 177 22 for for IN cord-328396-p2gvpe8i 177 23 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 177 24 and and CC cord-328396-p2gvpe8i 177 25 in in IN cord-328396-p2gvpe8i 177 26 fact fact NN cord-328396-p2gvpe8i 177 27 for for IN cord-328396-p2gvpe8i 177 28 viral viral JJ cord-328396-p2gvpe8i 177 29 sepsis sepsis NN cord-328396-p2gvpe8i 177 30 in in IN cord-328396-p2gvpe8i 177 31 general general JJ cord-328396-p2gvpe8i 177 32 . . . cord-328396-p2gvpe8i 178 1 The the DT cord-328396-p2gvpe8i 178 2 original original JJ cord-328396-p2gvpe8i 178 3 contributions contribution NNS cord-328396-p2gvpe8i 178 4 presented present VBN cord-328396-p2gvpe8i 178 5 in in IN cord-328396-p2gvpe8i 178 6 the the DT cord-328396-p2gvpe8i 178 7 study study NN cord-328396-p2gvpe8i 178 8 are be VBP cord-328396-p2gvpe8i 178 9 included include VBN cord-328396-p2gvpe8i 178 10 in in IN cord-328396-p2gvpe8i 178 11 the the DT cord-328396-p2gvpe8i 178 12 article article NN cord-328396-p2gvpe8i 178 13 / / SYM cord-328396-p2gvpe8i 178 14 supplementary supplementary JJ cord-328396-p2gvpe8i 178 15 material material NN cord-328396-p2gvpe8i 178 16 , , , cord-328396-p2gvpe8i 178 17 further further JJ cord-328396-p2gvpe8i 178 18 inquiries inquiry NNS cord-328396-p2gvpe8i 178 19 can can MD cord-328396-p2gvpe8i 178 20 be be VB cord-328396-p2gvpe8i 178 21 directed direct VBN cord-328396-p2gvpe8i 178 22 to to IN cord-328396-p2gvpe8i 178 23 the the DT cord-328396-p2gvpe8i 178 24 corresponding correspond VBG cord-328396-p2gvpe8i 178 25 author author NN cord-328396-p2gvpe8i 178 26 . . . cord-328396-p2gvpe8i 179 1 Pulmonary pulmonary JJ cord-328396-p2gvpe8i 179 2 vascular vascular JJ cord-328396-p2gvpe8i 179 3 endothelialitis endothelialitis NN cord-328396-p2gvpe8i 179 4 , , , cord-328396-p2gvpe8i 179 5 thrombosis thrombosis NN cord-328396-p2gvpe8i 179 6 , , , cord-328396-p2gvpe8i 179 7 and and CC cord-328396-p2gvpe8i 179 8 angiogenesis angiogenesis NN cord-328396-p2gvpe8i 179 9 in in IN cord-328396-p2gvpe8i 179 10 Covid-19 Covid-19 NNP cord-328396-p2gvpe8i 179 11 Phenotypic phenotypic JJ cord-328396-p2gvpe8i 179 12 heterogeneity heterogeneity NN cord-328396-p2gvpe8i 179 13 of of IN cord-328396-p2gvpe8i 179 14 the the DT cord-328396-p2gvpe8i 179 15 endothelium endothelium NN cord-328396-p2gvpe8i 179 16 : : : cord-328396-p2gvpe8i 179 17 II II NNP cord-328396-p2gvpe8i 179 18 . . . cord-328396-p2gvpe8i 180 1 Representative representative JJ cord-328396-p2gvpe8i 180 2 vascular vascular JJ cord-328396-p2gvpe8i 180 3 beds bed NNS cord-328396-p2gvpe8i 181 1 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 181 2 and and CC cord-328396-p2gvpe8i 181 3 dysfunctional dysfunctional JJ cord-328396-p2gvpe8i 181 4 endothelium endothelium NN cord-328396-p2gvpe8i 181 5 : : : cord-328396-p2gvpe8i 181 6 the the DT cord-328396-p2gvpe8i 181 7 mexican mexican JJ cord-328396-p2gvpe8i 181 8 scenario scenario NN cord-328396-p2gvpe8i 182 1 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 182 2 , , , cord-328396-p2gvpe8i 182 3 renin renin NN cord-328396-p2gvpe8i 182 4 - - HYPH cord-328396-p2gvpe8i 182 5 angiotensin angiotensin NN cord-328396-p2gvpe8i 182 6 system system NN cord-328396-p2gvpe8i 182 7 and and CC cord-328396-p2gvpe8i 182 8 endothelial endothelial JJ cord-328396-p2gvpe8i 182 9 dysfunction dysfunction NN cord-328396-p2gvpe8i 182 10 SARS SARS NNP cord-328396-p2gvpe8i 182 11 - - : cord-328396-p2gvpe8i 182 12 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 182 13 endothelial endothelial JJ cord-328396-p2gvpe8i 182 14 infection infection NN cord-328396-p2gvpe8i 182 15 causes cause VBZ cord-328396-p2gvpe8i 183 1 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 183 2 chilblains chilblains NNPS cord-328396-p2gvpe8i 183 3 : : : cord-328396-p2gvpe8i 183 4 histopathological histopathological NNP cord-328396-p2gvpe8i 183 5 , , , cord-328396-p2gvpe8i 183 6 immunohistochemical immunohistochemical NNP cord-328396-p2gvpe8i 183 7 and and CC cord-328396-p2gvpe8i 183 8 ultraestructural ultraestructural NNP cord-328396-p2gvpe8i 183 9 study study NNP cord-328396-p2gvpe8i 183 10 of of IN cord-328396-p2gvpe8i 183 11 7 7 CD cord-328396-p2gvpe8i 183 12 paediatric paediatric JJ cord-328396-p2gvpe8i 183 13 cases case NNS cord-328396-p2gvpe8i 183 14 COVID-19 covid-19 VBP cord-328396-p2gvpe8i 183 15 May May MD cord-328396-p2gvpe8i 183 16 predispose predispose VB cord-328396-p2gvpe8i 183 17 to to TO cord-328396-p2gvpe8i 183 18 thrombosis thrombosis NN cord-328396-p2gvpe8i 183 19 by by IN cord-328396-p2gvpe8i 183 20 affecting affect VBG cord-328396-p2gvpe8i 183 21 both both DT cord-328396-p2gvpe8i 183 22 vascular vascular JJ cord-328396-p2gvpe8i 183 23 endothelium endothelium NN cord-328396-p2gvpe8i 183 24 and and CC cord-328396-p2gvpe8i 183 25 platelets platelet NNS cord-328396-p2gvpe8i 184 1 The the DT cord-328396-p2gvpe8i 184 2 clinical clinical JJ cord-328396-p2gvpe8i 184 3 pathology pathology NN cord-328396-p2gvpe8i 184 4 of of IN cord-328396-p2gvpe8i 184 5 severe severe JJ cord-328396-p2gvpe8i 184 6 acute acute JJ cord-328396-p2gvpe8i 184 7 respiratory respiratory JJ cord-328396-p2gvpe8i 184 8 syndrome syndrome NN cord-328396-p2gvpe8i 184 9 ( ( -LRB- cord-328396-p2gvpe8i 184 10 SARS SARS NNP cord-328396-p2gvpe8i 184 11 ) ) -RRB- cord-328396-p2gvpe8i 184 12 : : : cord-328396-p2gvpe8i 185 1 a a DT cord-328396-p2gvpe8i 185 2 report report NN cord-328396-p2gvpe8i 185 3 from from IN cord-328396-p2gvpe8i 185 4 Role role NN cord-328396-p2gvpe8i 185 5 of of IN cord-328396-p2gvpe8i 185 6 the the DT cord-328396-p2gvpe8i 185 7 chronic chronic JJ cord-328396-p2gvpe8i 185 8 air air NN cord-328396-p2gvpe8i 185 9 pollution pollution NN cord-328396-p2gvpe8i 185 10 levels level NNS cord-328396-p2gvpe8i 185 11 in in IN cord-328396-p2gvpe8i 185 12 the the DT cord-328396-p2gvpe8i 185 13 Covid-19 covid-19 JJ cord-328396-p2gvpe8i 185 14 outbreak outbreak NN cord-328396-p2gvpe8i 185 15 risk risk NN cord-328396-p2gvpe8i 185 16 in in IN cord-328396-p2gvpe8i 185 17 Italy Italy NNP cord-328396-p2gvpe8i 185 18 Pulmonary Pulmonary NNP cord-328396-p2gvpe8i 185 19 and and CC cord-328396-p2gvpe8i 185 20 cardiac cardiac JJ cord-328396-p2gvpe8i 185 21 pathology pathology NN cord-328396-p2gvpe8i 185 22 in in IN cord-328396-p2gvpe8i 185 23 Covid-19 Covid-19 NNP cord-328396-p2gvpe8i 185 24 : : : cord-328396-p2gvpe8i 185 25 the the DT cord-328396-p2gvpe8i 185 26 first first JJ cord-328396-p2gvpe8i 185 27 autopsy autopsy JJ cord-328396-p2gvpe8i 185 28 series series NN cord-328396-p2gvpe8i 185 29 from from IN cord-328396-p2gvpe8i 185 30 new new NNP cord-328396-p2gvpe8i 185 31 orleans orleans NNP cord-328396-p2gvpe8i 185 32 Endothelial Endothelial NNP cord-328396-p2gvpe8i 185 33 dysfunction dysfunction NN cord-328396-p2gvpe8i 185 34 in in IN cord-328396-p2gvpe8i 185 35 Coronavirus Coronavirus NNP cord-328396-p2gvpe8i 185 36 disease disease NN cord-328396-p2gvpe8i 185 37 2019 2019 CD cord-328396-p2gvpe8i 185 38 ( ( -LRB- cord-328396-p2gvpe8i 185 39 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 185 40 ) ) -RRB- cord-328396-p2gvpe8i 185 41 : : : cord-328396-p2gvpe8i 185 42 gender gender NN cord-328396-p2gvpe8i 185 43 and and CC cord-328396-p2gvpe8i 185 44 age age NN cord-328396-p2gvpe8i 185 45 influences influence VBZ cord-328396-p2gvpe8i 185 46 Physiology Physiology NNP cord-328396-p2gvpe8i 185 47 of of IN cord-328396-p2gvpe8i 185 48 the the DT cord-328396-p2gvpe8i 185 49 endothelium endothelium NN cord-328396-p2gvpe8i 186 1 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 186 2 pneumonia pneumonia NN cord-328396-p2gvpe8i 186 3 : : : cord-328396-p2gvpe8i 186 4 different different JJ cord-328396-p2gvpe8i 186 5 respiratory respiratory JJ cord-328396-p2gvpe8i 186 6 treatments treatment NNS cord-328396-p2gvpe8i 186 7 for for IN cord-328396-p2gvpe8i 186 8 different different JJ cord-328396-p2gvpe8i 186 9 phenotypes phenotype NNS cord-328396-p2gvpe8i 186 10 ? ? . cord-328396-p2gvpe8i 187 1 Complex complex JJ cord-328396-p2gvpe8i 187 2 immune immune JJ cord-328396-p2gvpe8i 187 3 dysregulation dysregulation NN cord-328396-p2gvpe8i 187 4 in in IN cord-328396-p2gvpe8i 187 5 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 187 6 patients patient NNS cord-328396-p2gvpe8i 187 7 with with IN cord-328396-p2gvpe8i 187 8 severe severe JJ cord-328396-p2gvpe8i 187 9 respiratory respiratory JJ cord-328396-p2gvpe8i 187 10 failure failure NN cord-328396-p2gvpe8i 188 1 Increased increase VBN cord-328396-p2gvpe8i 188 2 sFLT1 sFLT1 NNP cord-328396-p2gvpe8i 188 3 / / SYM cord-328396-p2gvpe8i 188 4 PlGF plgf NN cord-328396-p2gvpe8i 188 5 ratio ratio NN cord-328396-p2gvpe8i 188 6 in in IN cord-328396-p2gvpe8i 188 7 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 188 8 : : : cord-328396-p2gvpe8i 188 9 a a DT cord-328396-p2gvpe8i 188 10 novel novel JJ cord-328396-p2gvpe8i 188 11 link link NN cord-328396-p2gvpe8i 188 12 to to IN cord-328396-p2gvpe8i 188 13 Angiotensin Angiotensin NNP cord-328396-p2gvpe8i 188 14 II II NNP cord-328396-p2gvpe8i 188 15 - - HYPH cord-328396-p2gvpe8i 188 16 mediated mediate VBN cord-328396-p2gvpe8i 188 17 endothelial endothelial JJ cord-328396-p2gvpe8i 188 18 dysfunction dysfunction NN cord-328396-p2gvpe8i 188 19 Endotheliopathy Endotheliopathy NNP cord-328396-p2gvpe8i 188 20 in in IN cord-328396-p2gvpe8i 188 21 COVID-19-associated covid-19-associated JJ cord-328396-p2gvpe8i 188 22 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 188 23 : : : cord-328396-p2gvpe8i 188 24 evidence evidence NN cord-328396-p2gvpe8i 188 25 from from IN cord-328396-p2gvpe8i 188 26 a a DT cord-328396-p2gvpe8i 188 27 single single JJ cord-328396-p2gvpe8i 188 28 - - HYPH cord-328396-p2gvpe8i 188 29 centre centre NN cord-328396-p2gvpe8i 188 30 , , , cord-328396-p2gvpe8i 188 31 cross cross JJ cord-328396-p2gvpe8i 188 32 - - JJ cord-328396-p2gvpe8i 188 33 sectional sectional JJ cord-328396-p2gvpe8i 188 34 study study NN cord-328396-p2gvpe8i 189 1 The the DT cord-328396-p2gvpe8i 189 2 endothelium endothelium NN cord-328396-p2gvpe8i 189 3 in in IN cord-328396-p2gvpe8i 189 4 hypoxic hypoxic JJ cord-328396-p2gvpe8i 189 5 pulmonary pulmonary JJ cord-328396-p2gvpe8i 189 6 vasoconstriction vasoconstriction NN cord-328396-p2gvpe8i 189 7 Is be VBZ cord-328396-p2gvpe8i 189 8 the the DT cord-328396-p2gvpe8i 189 9 reason reason NN cord-328396-p2gvpe8i 189 10 of of IN cord-328396-p2gvpe8i 189 11 increased increase VBN cord-328396-p2gvpe8i 189 12 D d NN cord-328396-p2gvpe8i 189 13 - - HYPH cord-328396-p2gvpe8i 189 14 dimer dimer NN cord-328396-p2gvpe8i 189 15 levels level NNS cord-328396-p2gvpe8i 189 16 in in IN cord-328396-p2gvpe8i 189 17 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 189 18 because because IN cord-328396-p2gvpe8i 189 19 of of IN cord-328396-p2gvpe8i 189 20 ACE-2-induced ace-2-induced JJ cord-328396-p2gvpe8i 189 21 apoptosis apoptosis NN cord-328396-p2gvpe8i 189 22 in in IN cord-328396-p2gvpe8i 189 23 endothelium endothelium NN cord-328396-p2gvpe8i 189 24 ? ? . cord-328396-p2gvpe8i 190 1 Extrapulmonary Extrapulmonary NNP cord-328396-p2gvpe8i 190 2 manifestations manifestation NNS cord-328396-p2gvpe8i 190 3 of of IN cord-328396-p2gvpe8i 190 4 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 190 5 Overcoming overcome VBG cord-328396-p2gvpe8i 190 6 barriers barrier NNS cord-328396-p2gvpe8i 190 7 : : : cord-328396-p2gvpe8i 190 8 the the DT cord-328396-p2gvpe8i 190 9 endothelium endothelium NN cord-328396-p2gvpe8i 190 10 as as IN cord-328396-p2gvpe8i 190 11 a a DT cord-328396-p2gvpe8i 190 12 linchpin linchpin NN cord-328396-p2gvpe8i 190 13 of of IN cord-328396-p2gvpe8i 190 14 coronavirus coronavirus NN cord-328396-p2gvpe8i 190 15 disease disease NN cord-328396-p2gvpe8i 190 16 2019 2019 CD cord-328396-p2gvpe8i 190 17 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 190 18 Tissue tissue NN cord-328396-p2gvpe8i 190 19 distribution distribution NN cord-328396-p2gvpe8i 190 20 of of IN cord-328396-p2gvpe8i 190 21 ACE2 ACE2 NNP cord-328396-p2gvpe8i 190 22 protein protein NN cord-328396-p2gvpe8i 190 23 , , , cord-328396-p2gvpe8i 190 24 the the DT cord-328396-p2gvpe8i 190 25 functional functional JJ cord-328396-p2gvpe8i 190 26 receptor receptor NN cord-328396-p2gvpe8i 190 27 for for IN cord-328396-p2gvpe8i 190 28 SARS SARS NNP cord-328396-p2gvpe8i 190 29 coronavirus coronavirus NN cord-328396-p2gvpe8i 190 30 . . . cord-328396-p2gvpe8i 191 1 A a DT cord-328396-p2gvpe8i 191 2 first first JJ cord-328396-p2gvpe8i 191 3 step step NN cord-328396-p2gvpe8i 191 4 in in IN cord-328396-p2gvpe8i 191 5 understanding understand VBG cord-328396-p2gvpe8i 191 6 SARS SARS NNP cord-328396-p2gvpe8i 191 7 pathogenesis pathogenesis VBP cord-328396-p2gvpe8i 191 8 Endothelial endothelial JJ cord-328396-p2gvpe8i 191 9 biomarkers biomarker NNS cord-328396-p2gvpe8i 191 10 in in IN cord-328396-p2gvpe8i 191 11 human human JJ cord-328396-p2gvpe8i 191 12 sepsis sepsis NN cord-328396-p2gvpe8i 191 13 : : : cord-328396-p2gvpe8i 191 14 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 191 15 and and CC cord-328396-p2gvpe8i 191 16 prognosis prognosis NN cord-328396-p2gvpe8i 191 17 for for IN cord-328396-p2gvpe8i 191 18 ARDS ARDS NNP cord-328396-p2gvpe8i 191 19 SARS SARS NNP cord-328396-p2gvpe8i 191 20 - - HYPH cord-328396-p2gvpe8i 191 21 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 191 22 cell cell NN cord-328396-p2gvpe8i 191 23 entry entry NN cord-328396-p2gvpe8i 191 24 depends depend VBZ cord-328396-p2gvpe8i 191 25 on on IN cord-328396-p2gvpe8i 191 26 ACE2 ACE2 NNP cord-328396-p2gvpe8i 191 27 and and CC cord-328396-p2gvpe8i 191 28 TMPRSS2 TMPRSS2 NNP cord-328396-p2gvpe8i 191 29 and and CC cord-328396-p2gvpe8i 191 30 is be VBZ cord-328396-p2gvpe8i 191 31 blocked block VBN cord-328396-p2gvpe8i 191 32 by by IN cord-328396-p2gvpe8i 191 33 a a DT cord-328396-p2gvpe8i 191 34 clinically clinically RB cord-328396-p2gvpe8i 191 35 proven prove VBN cord-328396-p2gvpe8i 191 36 protease protease NN cord-328396-p2gvpe8i 191 37 inhibitor inhibitor NN cord-328396-p2gvpe8i 191 38 Clinical clinical JJ cord-328396-p2gvpe8i 191 39 features feature NNS cord-328396-p2gvpe8i 191 40 of of IN cord-328396-p2gvpe8i 191 41 patients patient NNS cord-328396-p2gvpe8i 191 42 infected infect VBN cord-328396-p2gvpe8i 191 43 with with IN cord-328396-p2gvpe8i 191 44 2019 2019 CD cord-328396-p2gvpe8i 191 45 novel novel JJ cord-328396-p2gvpe8i 191 46 coronavirus coronavirus NN cord-328396-p2gvpe8i 191 47 in in IN cord-328396-p2gvpe8i 191 48 Wuhan Wuhan NNP cord-328396-p2gvpe8i 191 49 Angiotensinconverting Angiotensinconverting NNP cord-328396-p2gvpe8i 191 50 enzyme enzyme NN cord-328396-p2gvpe8i 191 51 2 2 CD cord-328396-p2gvpe8i 191 52 protects protect VBZ cord-328396-p2gvpe8i 191 53 from from IN cord-328396-p2gvpe8i 191 54 severe severe JJ cord-328396-p2gvpe8i 191 55 acute acute JJ cord-328396-p2gvpe8i 191 56 lung lung NN cord-328396-p2gvpe8i 191 57 failure failure NN cord-328396-p2gvpe8i 191 58 CD209L CD209L NNP cord-328396-p2gvpe8i 192 1 ( ( -LRB- cord-328396-p2gvpe8i 192 2 L l NN cord-328396-p2gvpe8i 192 3 - - HYPH cord-328396-p2gvpe8i 192 4 SIGN SIGN NNP cord-328396-p2gvpe8i 192 5 ) ) -RRB- cord-328396-p2gvpe8i 192 6 is be VBZ cord-328396-p2gvpe8i 192 7 a a DT cord-328396-p2gvpe8i 192 8 receptor receptor NN cord-328396-p2gvpe8i 192 9 for for IN cord-328396-p2gvpe8i 192 10 severe severe JJ cord-328396-p2gvpe8i 192 11 acute acute JJ cord-328396-p2gvpe8i 192 12 respiratory respiratory JJ cord-328396-p2gvpe8i 192 13 syndrome syndrome NN cord-328396-p2gvpe8i 192 14 coronavirus coronavirus NN cord-328396-p2gvpe8i 192 15 Confirmation Confirmation NNP cord-328396-p2gvpe8i 192 16 of of IN cord-328396-p2gvpe8i 192 17 the the DT cord-328396-p2gvpe8i 192 18 high high JJ cord-328396-p2gvpe8i 192 19 cumulative cumulative JJ cord-328396-p2gvpe8i 192 20 incidence incidence NN cord-328396-p2gvpe8i 192 21 of of IN cord-328396-p2gvpe8i 192 22 thrombotic thrombotic JJ cord-328396-p2gvpe8i 192 23 complications complication NNS cord-328396-p2gvpe8i 192 24 in in IN cord-328396-p2gvpe8i 192 25 critically critically RB cord-328396-p2gvpe8i 192 26 ill ill JJ cord-328396-p2gvpe8i 192 27 ICU ICU NNP cord-328396-p2gvpe8i 192 28 patients patient NNS cord-328396-p2gvpe8i 192 29 with with IN cord-328396-p2gvpe8i 192 30 COVID-19 covid-19 NN cord-328396-p2gvpe8i 192 31 : : : cord-328396-p2gvpe8i 193 1 An an DT cord-328396-p2gvpe8i 193 2 updated update VBN cord-328396-p2gvpe8i 193 3 analysis analysis NN cord-328396-p2gvpe8i 193 4 Coronavirus Coronavirus NNP cord-328396-p2gvpe8i 193 5 breakthrough breakthrough NN cord-328396-p2gvpe8i 194 1 : : : cord-328396-p2gvpe8i 194 2 dexamethasone dexamethasone NNP cord-328396-p2gvpe8i 194 3 is be VBZ cord-328396-p2gvpe8i 194 4 first first JJ cord-328396-p2gvpe8i 194 5 drug drug NN cord-328396-p2gvpe8i 194 6 shown show VBN cord-328396-p2gvpe8i 194 7 to to TO cord-328396-p2gvpe8i 194 8 save save VB cord-328396-p2gvpe8i 194 9 lives life NNS cord-328396-p2gvpe8i 194 10 SARS SARS NNP cord-328396-p2gvpe8i 194 11 - - HYPH cord-328396-p2gvpe8i 194 12 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 194 13 and and CC cord-328396-p2gvpe8i 194 14 viral viral JJ cord-328396-p2gvpe8i 194 15 sepsis sepsis NN cord-328396-p2gvpe8i 194 16 : : : cord-328396-p2gvpe8i 194 17 observations observation NNS cord-328396-p2gvpe8i 194 18 and and CC cord-328396-p2gvpe8i 194 19 hypotheses hypothesis NNS cord-328396-p2gvpe8i 194 20 Procalcitonin Procalcitonin NNPS cord-328396-p2gvpe8i 194 21 in in IN cord-328396-p2gvpe8i 194 22 patients patient NNS cord-328396-p2gvpe8i 194 23 with with IN cord-328396-p2gvpe8i 194 24 severe severe JJ cord-328396-p2gvpe8i 194 25 coronavirus coronavirus NN cord-328396-p2gvpe8i 194 26 disease disease NN cord-328396-p2gvpe8i 194 27 2019 2019 CD cord-328396-p2gvpe8i 194 28 ( ( -LRB- cord-328396-p2gvpe8i 194 29 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 194 30 ) ) -RRB- cord-328396-p2gvpe8i 194 31 : : : cord-328396-p2gvpe8i 195 1 A a DT cord-328396-p2gvpe8i 195 2 meta meta JJ cord-328396-p2gvpe8i 195 3 - - HYPH cord-328396-p2gvpe8i 195 4 analysis analysis NN cord-328396-p2gvpe8i 195 5 Neutrophilto Neutrophilto NNP cord-328396-p2gvpe8i 195 6 - - HYPH cord-328396-p2gvpe8i 195 7 lymphocyte lymphocyte NN cord-328396-p2gvpe8i 195 8 ratio ratio NN cord-328396-p2gvpe8i 195 9 as as IN cord-328396-p2gvpe8i 195 10 an an DT cord-328396-p2gvpe8i 195 11 independent independent JJ cord-328396-p2gvpe8i 195 12 risk risk NN cord-328396-p2gvpe8i 195 13 factor factor NN cord-328396-p2gvpe8i 195 14 for for IN cord-328396-p2gvpe8i 195 15 mortality mortality NN cord-328396-p2gvpe8i 195 16 in in IN cord-328396-p2gvpe8i 195 17 hospitalized hospitalize VBN cord-328396-p2gvpe8i 195 18 patients patient NNS cord-328396-p2gvpe8i 195 19 with with IN cord-328396-p2gvpe8i 195 20 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 195 21 COVID COVID NNP cord-328396-p2gvpe8i 195 22 - - HYPH cord-328396-p2gvpe8i 195 23 ARDS ARDS NNP cord-328396-p2gvpe8i 195 24 clarified clarify VBD cord-328396-p2gvpe8i 195 25 : : : cord-328396-p2gvpe8i 195 26 a a DT cord-328396-p2gvpe8i 195 27 vascular vascular JJ cord-328396-p2gvpe8i 195 28 endotype endotype NN cord-328396-p2gvpe8i 195 29 ? ? . cord-328396-p2gvpe8i 196 1 COVID-19 covid-19 VB cord-328396-p2gvpe8i 197 1 related related JJ cord-328396-p2gvpe8i 197 2 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 197 3 : : : cord-328396-p2gvpe8i 197 4 a a DT cord-328396-p2gvpe8i 197 5 distinct distinct JJ cord-328396-p2gvpe8i 197 6 entity entity NN cord-328396-p2gvpe8i 197 7 ? ? . cord-328396-p2gvpe8i 198 1 COVID-19-driven COVID-19-driven NNP cord-328396-p2gvpe8i 198 2 endothelial endothelial JJ cord-328396-p2gvpe8i 198 3 damage damage NN cord-328396-p2gvpe8i 198 4 : : : cord-328396-p2gvpe8i 198 5 complement complement NN cord-328396-p2gvpe8i 198 6 , , , cord-328396-p2gvpe8i 198 7 HIF-1 HIF-1 NNP cord-328396-p2gvpe8i 198 8 , , , cord-328396-p2gvpe8i 198 9 and and CC cord-328396-p2gvpe8i 198 10 ABL2 ABL2 NNP cord-328396-p2gvpe8i 198 11 are be VBP cord-328396-p2gvpe8i 198 12 potential potential JJ cord-328396-p2gvpe8i 198 13 pathways pathway NNS cord-328396-p2gvpe8i 198 14 of of IN cord-328396-p2gvpe8i 198 15 damage damage NN cord-328396-p2gvpe8i 198 16 and and CC cord-328396-p2gvpe8i 198 17 targets target NNS cord-328396-p2gvpe8i 198 18 for for IN cord-328396-p2gvpe8i 198 19 cure cure NN cord-328396-p2gvpe8i 198 20 Acute acute JJ cord-328396-p2gvpe8i 198 21 respiratory respiratory JJ cord-328396-p2gvpe8i 198 22 distress distress NN cord-328396-p2gvpe8i 198 23 syndrome syndrome NN cord-328396-p2gvpe8i 198 24 Immune immune JJ cord-328396-p2gvpe8i 198 25 mechanisms mechanism NNS cord-328396-p2gvpe8i 198 26 of of IN cord-328396-p2gvpe8i 198 27 pulmonary pulmonary JJ cord-328396-p2gvpe8i 198 28 intravascular intravascular JJ cord-328396-p2gvpe8i 198 29 coagulopathy coagulopathy NN cord-328396-p2gvpe8i 198 30 in in IN cord-328396-p2gvpe8i 198 31 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 198 32 pneumonia pneumonia NN cord-328396-p2gvpe8i 199 1 The the DT cord-328396-p2gvpe8i 199 2 pulmonary pulmonary JJ cord-328396-p2gvpe8i 199 3 endothelium endothelium NN cord-328396-p2gvpe8i 199 4 in in IN cord-328396-p2gvpe8i 199 5 acute acute JJ cord-328396-p2gvpe8i 199 6 respiratory respiratory JJ cord-328396-p2gvpe8i 199 7 distress distress NN cord-328396-p2gvpe8i 199 8 syndrome syndrome NN cord-328396-p2gvpe8i 199 9 : : : cord-328396-p2gvpe8i 199 10 insights insight NNS cord-328396-p2gvpe8i 199 11 and and CC cord-328396-p2gvpe8i 199 12 therapeutic therapeutic JJ cord-328396-p2gvpe8i 199 13 opportunities opportunity NNS cord-328396-p2gvpe8i 200 1 COVID-19 covid-19 LS cord-328396-p2gvpe8i 200 2 : : : cord-328396-p2gvpe8i 200 3 Are be VBP cord-328396-p2gvpe8i 200 4 we -PRON- PRP cord-328396-p2gvpe8i 200 5 dealing deal VBG cord-328396-p2gvpe8i 200 6 with with IN cord-328396-p2gvpe8i 200 7 a a DT cord-328396-p2gvpe8i 200 8 multisystem multisystem JJ cord-328396-p2gvpe8i 200 9 vasculopathy vasculopathy NN cord-328396-p2gvpe8i 200 10 in in IN cord-328396-p2gvpe8i 200 11 disguise disguise NN cord-328396-p2gvpe8i 200 12 of of IN cord-328396-p2gvpe8i 200 13 a a DT cord-328396-p2gvpe8i 200 14 viral viral JJ cord-328396-p2gvpe8i 200 15 infection infection NN cord-328396-p2gvpe8i 201 1 Inhibition inhibition NN cord-328396-p2gvpe8i 201 2 of of IN cord-328396-p2gvpe8i 201 3 SARS SARS NNP cord-328396-p2gvpe8i 201 4 - - HYPH cord-328396-p2gvpe8i 201 5 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 201 6 infections infection NNS cord-328396-p2gvpe8i 201 7 in in IN cord-328396-p2gvpe8i 201 8 engineered engineer VBN cord-328396-p2gvpe8i 201 9 human human JJ cord-328396-p2gvpe8i 201 10 tissues tissue NNS cord-328396-p2gvpe8i 201 11 using use VBG cord-328396-p2gvpe8i 201 12 clinical clinical JJ cord-328396-p2gvpe8i 201 13 - - HYPH cord-328396-p2gvpe8i 201 14 grade grade NN cord-328396-p2gvpe8i 201 15 soluble soluble JJ cord-328396-p2gvpe8i 201 16 human human JJ cord-328396-p2gvpe8i 201 17 ACE2 ACE2 NNP cord-328396-p2gvpe8i 201 18 Excessive excessive JJ cord-328396-p2gvpe8i 201 19 neutrophils neutrophil NNS cord-328396-p2gvpe8i 201 20 and and CC cord-328396-p2gvpe8i 201 21 neutrophil neutrophil NN cord-328396-p2gvpe8i 201 22 extracellular extracellular JJ cord-328396-p2gvpe8i 201 23 traps trap NNS cord-328396-p2gvpe8i 201 24 contribute contribute VBP cord-328396-p2gvpe8i 201 25 to to IN cord-328396-p2gvpe8i 201 26 acute acute JJ cord-328396-p2gvpe8i 201 27 lung lung NN cord-328396-p2gvpe8i 201 28 injury injury NN cord-328396-p2gvpe8i 201 29 of of IN cord-328396-p2gvpe8i 201 30 influenza influenza NN cord-328396-p2gvpe8i 201 31 pneumonitis pneumonitis NN cord-328396-p2gvpe8i 201 32 Large large JJ cord-328396-p2gvpe8i 201 33 - - HYPH cord-328396-p2gvpe8i 201 34 vessel vessel NN cord-328396-p2gvpe8i 201 35 stroke stroke NN cord-328396-p2gvpe8i 201 36 as as IN cord-328396-p2gvpe8i 201 37 a a DT cord-328396-p2gvpe8i 201 38 presenting present VBG cord-328396-p2gvpe8i 201 39 feature feature NN cord-328396-p2gvpe8i 201 40 of of IN cord-328396-p2gvpe8i 201 41 Covid-19 covid-19 NN cord-328396-p2gvpe8i 201 42 in in IN cord-328396-p2gvpe8i 201 43 the the DT cord-328396-p2gvpe8i 201 44 young young JJ cord-328396-p2gvpe8i 201 45 Potential potential JJ cord-328396-p2gvpe8i 201 46 role role NN cord-328396-p2gvpe8i 201 47 of of IN cord-328396-p2gvpe8i 201 48 endothelial endothelial JJ cord-328396-p2gvpe8i 201 49 cell cell NN cord-328396-p2gvpe8i 201 50 surface surface NN cord-328396-p2gvpe8i 201 51 ectopic ectopic JJ cord-328396-p2gvpe8i 201 52 redox redox NN cord-328396-p2gvpe8i 201 53 complexes complex NNS cord-328396-p2gvpe8i 201 54 in in IN cord-328396-p2gvpe8i 201 55 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 201 56 disease disease NN cord-328396-p2gvpe8i 201 57 pathogenesis pathogenesis NN cord-328396-p2gvpe8i 202 1 The the DT cord-328396-p2gvpe8i 202 2 vascular vascular JJ cord-328396-p2gvpe8i 202 3 endothelium endothelium NN cord-328396-p2gvpe8i 202 4 : : : cord-328396-p2gvpe8i 202 5 the the DT cord-328396-p2gvpe8i 202 6 cornerstone cornerstone NNP cord-328396-p2gvpe8i 202 7 of of IN cord-328396-p2gvpe8i 202 8 organ organ NN cord-328396-p2gvpe8i 202 9 dysfunction dysfunction NN cord-328396-p2gvpe8i 202 10 in in IN cord-328396-p2gvpe8i 202 11 severe severe JJ cord-328396-p2gvpe8i 202 12 SARS SARS NNP cord-328396-p2gvpe8i 202 13 - - HYPH cord-328396-p2gvpe8i 202 14 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 202 15 infection infection NN cord-328396-p2gvpe8i 202 16 Multiorgan Multiorgan NNP cord-328396-p2gvpe8i 202 17 and and CC cord-328396-p2gvpe8i 202 18 renal renal JJ cord-328396-p2gvpe8i 202 19 tropism tropism NN cord-328396-p2gvpe8i 202 20 of of IN cord-328396-p2gvpe8i 202 21 SARS SARS NNP cord-328396-p2gvpe8i 202 22 - - HYPH cord-328396-p2gvpe8i 202 23 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 202 24 . . . cord-328396-p2gvpe8i 203 1 N. N. NNP cord-328396-p2gvpe8i 203 2 Eng Eng NNP cord-328396-p2gvpe8i 204 1 The the DT cord-328396-p2gvpe8i 204 2 procoagulant procoagulant JJ cord-328396-p2gvpe8i 204 3 pattern pattern NN cord-328396-p2gvpe8i 204 4 of of IN cord-328396-p2gvpe8i 204 5 patients patient NNS cord-328396-p2gvpe8i 204 6 with with IN cord-328396-p2gvpe8i 204 7 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 204 8 acute acute JJ cord-328396-p2gvpe8i 204 9 respiratory respiratory JJ cord-328396-p2gvpe8i 204 10 distress distress NN cord-328396-p2gvpe8i 204 11 syndrome syndrome NN cord-328396-p2gvpe8i 204 12 Hypertension hypertension NN cord-328396-p2gvpe8i 204 13 , , , cord-328396-p2gvpe8i 204 14 thrombosis thrombosis NN cord-328396-p2gvpe8i 204 15 , , , cord-328396-p2gvpe8i 204 16 kidney kidney NN cord-328396-p2gvpe8i 204 17 failure failure NN cord-328396-p2gvpe8i 204 18 , , , cord-328396-p2gvpe8i 204 19 and and CC cord-328396-p2gvpe8i 204 20 diabetes diabetes NN cord-328396-p2gvpe8i 204 21 : : : cord-328396-p2gvpe8i 204 22 is be VBZ cord-328396-p2gvpe8i 204 23 COVID-19 covid-19 VB cord-328396-p2gvpe8i 204 24 an an DT cord-328396-p2gvpe8i 204 25 endothelial endothelial JJ cord-328396-p2gvpe8i 204 26 disease disease NN cord-328396-p2gvpe8i 204 27 ? ? . cord-328396-p2gvpe8i 205 1 a a DT cord-328396-p2gvpe8i 205 2 comprehensive comprehensive JJ cord-328396-p2gvpe8i 205 3 evaluation evaluation NN cord-328396-p2gvpe8i 205 4 of of IN cord-328396-p2gvpe8i 205 5 clinical clinical JJ cord-328396-p2gvpe8i 205 6 and and CC cord-328396-p2gvpe8i 205 7 basic basic JJ cord-328396-p2gvpe8i 205 8 evidence evidence NN cord-328396-p2gvpe8i 205 9 Is be VBZ cord-328396-p2gvpe8i 205 10 COVID-19 covid-19 VB cord-328396-p2gvpe8i 205 11 an an DT cord-328396-p2gvpe8i 205 12 endothelial endothelial JJ cord-328396-p2gvpe8i 205 13 disease disease NN cord-328396-p2gvpe8i 205 14 ? ? . cord-328396-p2gvpe8i 206 1 In in IN cord-328396-p2gvpe8i 206 2 situ situ JJ cord-328396-p2gvpe8i 206 3 detection detection NN cord-328396-p2gvpe8i 206 4 of of IN cord-328396-p2gvpe8i 206 5 SARS SARS NNP cord-328396-p2gvpe8i 206 6 - - HYPH cord-328396-p2gvpe8i 206 7 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 206 8 in in IN cord-328396-p2gvpe8i 206 9 lungs lung NNS cord-328396-p2gvpe8i 206 10 and and CC cord-328396-p2gvpe8i 206 11 airways airway NNS cord-328396-p2gvpe8i 206 12 of of IN cord-328396-p2gvpe8i 206 13 patients patient NNS cord-328396-p2gvpe8i 206 14 with with IN cord-328396-p2gvpe8i 206 15 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 206 16 Neutrophil Neutrophil NNP cord-328396-p2gvpe8i 206 17 extracellular extracellular JJ cord-328396-p2gvpe8i 206 18 traps trap NNS cord-328396-p2gvpe8i 206 19 - - : cord-328396-p2gvpe8i 206 20 the the DT cord-328396-p2gvpe8i 206 21 dark dark JJ cord-328396-p2gvpe8i 206 22 side side NN cord-328396-p2gvpe8i 206 23 of of IN cord-328396-p2gvpe8i 206 24 neutrophils neutrophil NNS cord-328396-p2gvpe8i 207 1 COVID-19 covid-19 VB cord-328396-p2gvpe8i 207 2 : : : cord-328396-p2gvpe8i 207 3 the the DT cord-328396-p2gvpe8i 207 4 vasculature vasculature NN cord-328396-p2gvpe8i 207 5 unleashed unleash VBN cord-328396-p2gvpe8i 207 6 Endothelial endothelial JJ cord-328396-p2gvpe8i 207 7 cell cell NN cord-328396-p2gvpe8i 207 8 infection infection NN cord-328396-p2gvpe8i 207 9 and and CC cord-328396-p2gvpe8i 207 10 endothelitis endothelitis NN cord-328396-p2gvpe8i 207 11 in in IN cord-328396-p2gvpe8i 207 12 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 207 13 The the DT cord-328396-p2gvpe8i 207 14 role role NN cord-328396-p2gvpe8i 207 15 of of IN cord-328396-p2gvpe8i 207 16 angiogenic angiogenic JJ cord-328396-p2gvpe8i 207 17 factors factor NNS cord-328396-p2gvpe8i 207 18 and and CC cord-328396-p2gvpe8i 207 19 their -PRON- PRP$ cord-328396-p2gvpe8i 207 20 soluble soluble JJ cord-328396-p2gvpe8i 207 21 receptors receptor NNS cord-328396-p2gvpe8i 207 22 in in IN cord-328396-p2gvpe8i 207 23 acute acute JJ cord-328396-p2gvpe8i 207 24 lung lung NN cord-328396-p2gvpe8i 207 25 injury injury NN cord-328396-p2gvpe8i 207 26 ( ( -LRB- cord-328396-p2gvpe8i 207 27 ALI)/acute ali)/acute JJ cord-328396-p2gvpe8i 207 28 respiratory respiratory JJ cord-328396-p2gvpe8i 207 29 distress distress NN cord-328396-p2gvpe8i 207 30 syndrome syndrome NN cord-328396-p2gvpe8i 207 31 ( ( -LRB- cord-328396-p2gvpe8i 207 32 ARDS ARDS NNP cord-328396-p2gvpe8i 207 33 ) ) -RRB- cord-328396-p2gvpe8i 207 34 associated associate VBN cord-328396-p2gvpe8i 207 35 with with IN cord-328396-p2gvpe8i 207 36 critical critical JJ cord-328396-p2gvpe8i 207 37 illness illness NN cord-328396-p2gvpe8i 208 1 Particulate particulate NN cord-328396-p2gvpe8i 208 2 matter matter NN cord-328396-p2gvpe8i 208 3 disrupts disrupt VBZ cord-328396-p2gvpe8i 208 4 human human JJ cord-328396-p2gvpe8i 208 5 lung lung NN cord-328396-p2gvpe8i 208 6 endothelial endothelial JJ cord-328396-p2gvpe8i 208 7 cell cell NN cord-328396-p2gvpe8i 208 8 barrier barrier NN cord-328396-p2gvpe8i 208 9 integrity integrity NN cord-328396-p2gvpe8i 208 10 via via IN cord-328396-p2gvpe8i 208 11 Rho rho NN cord-328396-p2gvpe8i 208 12 - - HYPH cord-328396-p2gvpe8i 208 13 dependent dependent JJ cord-328396-p2gvpe8i 208 14 pathways pathway NNS cord-328396-p2gvpe8i 209 1 Endothelial endothelial JJ cord-328396-p2gvpe8i 209 2 progenitor progenitor NN cord-328396-p2gvpe8i 209 3 cells cell NNS cord-328396-p2gvpe8i 209 4 for for IN cord-328396-p2gvpe8i 209 5 acute acute JJ cord-328396-p2gvpe8i 209 6 respiratory respiratory JJ cord-328396-p2gvpe8i 209 7 distress distress NN cord-328396-p2gvpe8i 209 8 syndrome syndrome NN cord-328396-p2gvpe8i 209 9 treatment treatment NN cord-328396-p2gvpe8i 209 10 : : : cord-328396-p2gvpe8i 209 11 support support VB cord-328396-p2gvpe8i 209 12 your -PRON- PRP$ cord-328396-p2gvpe8i 209 13 local local JJ cord-328396-p2gvpe8i 209 14 sheriff sheriff NN cord-328396-p2gvpe8i 209 15 ! ! . cord-328396-p2gvpe8i 210 1 Am be VBP cord-328396-p2gvpe8i 210 2 Virological virological JJ cord-328396-p2gvpe8i 210 3 assessment assessment NN cord-328396-p2gvpe8i 210 4 of of IN cord-328396-p2gvpe8i 210 5 hospitalized hospitalize VBN cord-328396-p2gvpe8i 210 6 patients patient NNS cord-328396-p2gvpe8i 210 7 with with IN cord-328396-p2gvpe8i 210 8 COVID-2019 COVID-2019 NNP cord-328396-p2gvpe8i 210 9 Analysis Analysis NNP cord-328396-p2gvpe8i 210 10 of of IN cord-328396-p2gvpe8i 210 11 92 92 CD cord-328396-p2gvpe8i 210 12 deceased deceased JJ cord-328396-p2gvpe8i 210 13 patients patient NNS cord-328396-p2gvpe8i 210 14 with with IN cord-328396-p2gvpe8i 210 15 COVID-19 covid-19 JJ cord-328396-p2gvpe8i 210 16 Prevalence prevalence NN cord-328396-p2gvpe8i 210 17 of of IN cord-328396-p2gvpe8i 210 18 comorbidities comorbiditie NNS cord-328396-p2gvpe8i 210 19 in in IN cord-328396-p2gvpe8i 210 20 the the DT cord-328396-p2gvpe8i 210 21 novel novel JJ cord-328396-p2gvpe8i 210 22 Wuhan Wuhan NNP cord-328396-p2gvpe8i 210 23 coronavirus coronavirus NN cord-328396-p2gvpe8i 210 24 ( ( -LRB- cord-328396-p2gvpe8i 210 25 COVID-19 covid-19 VB cord-328396-p2gvpe8i 210 26 ) ) -RRB- cord-328396-p2gvpe8i 210 27 infection infection NN cord-328396-p2gvpe8i 210 28 : : : cord-328396-p2gvpe8i 210 29 a a DT cord-328396-p2gvpe8i 210 30 systematic systematic JJ cord-328396-p2gvpe8i 210 31 review review NN cord-328396-p2gvpe8i 210 32 and and CC cord-328396-p2gvpe8i 210 33 meta meta NNP cord-328396-p2gvpe8i 210 34 - - HYPH cord-328396-p2gvpe8i 210 35 analysis analysis NN cord-328396-p2gvpe8i 210 36 Clinical clinical JJ cord-328396-p2gvpe8i 210 37 course course NN cord-328396-p2gvpe8i 210 38 and and CC cord-328396-p2gvpe8i 210 39 outcomes outcome NNS cord-328396-p2gvpe8i 210 40 of of IN cord-328396-p2gvpe8i 210 41 critically critically RB cord-328396-p2gvpe8i 210 42 ill ill JJ cord-328396-p2gvpe8i 210 43 patients patient NNS cord-328396-p2gvpe8i 210 44 with with IN cord-328396-p2gvpe8i 210 45 SARS SARS NNP cord-328396-p2gvpe8i 210 46 - - HYPH cord-328396-p2gvpe8i 210 47 CoV-2 CoV-2 NNP cord-328396-p2gvpe8i 210 48 pneumonia pneumonia NN cord-328396-p2gvpe8i 210 49 in in IN cord-328396-p2gvpe8i 210 50 Wuhan Wuhan NNP cord-328396-p2gvpe8i 210 51 , , , cord-328396-p2gvpe8i 210 52 China China NNP cord-328396-p2gvpe8i 210 53 : : : cord-328396-p2gvpe8i 210 54 a a DT cord-328396-p2gvpe8i 210 55 single single RB cord-328396-p2gvpe8i 210 56 - - HYPH cord-328396-p2gvpe8i 210 57 centered centered JJ cord-328396-p2gvpe8i 210 58 , , , cord-328396-p2gvpe8i 210 59 retrospective retrospective JJ cord-328396-p2gvpe8i 210 60 , , , cord-328396-p2gvpe8i 210 61 observational observational JJ cord-328396-p2gvpe8i 210 62 study study NN cord-328396-p2gvpe8i 210 63 Surface Surface NNP cord-328396-p2gvpe8i 210 64 vimentin vimentin NNP cord-328396-p2gvpe8i 210 65 is be VBZ cord-328396-p2gvpe8i 210 66 critical critical JJ cord-328396-p2gvpe8i 210 67 for for IN cord-328396-p2gvpe8i 210 68 the the DT cord-328396-p2gvpe8i 210 69 cell cell NN cord-328396-p2gvpe8i 210 70 entry entry NN cord-328396-p2gvpe8i 210 71 of of IN cord-328396-p2gvpe8i 210 72 SARS SARS NNP cord-328396-p2gvpe8i 210 73 - - HYPH cord-328396-p2gvpe8i 210 74 CoV CoV NNP cord-328396-p2gvpe8i 210 75 Bacterial bacterial JJ cord-328396-p2gvpe8i 210 76 and and CC cord-328396-p2gvpe8i 210 77 fungal fungal JJ cord-328396-p2gvpe8i 210 78 infections infection NNS cord-328396-p2gvpe8i 210 79 in in IN cord-328396-p2gvpe8i 210 80 COVID-19 covid-19 CD cord-328396-p2gvpe8i 210 81 patients patient NNS cord-328396-p2gvpe8i 210 82 : : : cord-328396-p2gvpe8i 210 83 a a DT cord-328396-p2gvpe8i 210 84 matter matter NN cord-328396-p2gvpe8i 210 85 of of IN cord-328396-p2gvpe8i 210 86 concern concern NN cord-328396-p2gvpe8i 210 87 Endothelial endothelial JJ cord-328396-p2gvpe8i 210 88 response response NN cord-328396-p2gvpe8i 210 89 to to IN cord-328396-p2gvpe8i 210 90 glucocorticoids glucocorticoid NNS cord-328396-p2gvpe8i 210 91 in in IN cord-328396-p2gvpe8i 210 92 inflammatory inflammatory JJ cord-328396-p2gvpe8i 210 93 diseases disease NNS cord-328396-p2gvpe8i 211 1 Neutrophil Neutrophil NNP cord-328396-p2gvpe8i 211 2 extracellular extracellular JJ cord-328396-p2gvpe8i 211 3 traps trap NNS cord-328396-p2gvpe8i 211 4 in in IN cord-328396-p2gvpe8i 211 5 COVID-19 COVID-19 NNP cord-328396-p2gvpe8i 211 6 SK SK NNP cord-328396-p2gvpe8i 211 7 developed develop VBD cord-328396-p2gvpe8i 211 8 these these DT cord-328396-p2gvpe8i 211 9 perspectives perspective NNS cord-328396-p2gvpe8i 211 10 . . . cord-328396-p2gvpe8i 212 1 SK SK NNP cord-328396-p2gvpe8i 212 2 and and CC cord-328396-p2gvpe8i 212 3 DT DT NNP cord-328396-p2gvpe8i 212 4 together together RB cord-328396-p2gvpe8i 212 5 drafted draft VBD cord-328396-p2gvpe8i 212 6 the the DT cord-328396-p2gvpe8i 212 7 manuscript manuscript NN cord-328396-p2gvpe8i 212 8 . . . cord-328396-p2gvpe8i 213 1 AY AY NNP cord-328396-p2gvpe8i 213 2 provided provide VBD cord-328396-p2gvpe8i 213 3 support support NN cord-328396-p2gvpe8i 213 4 in in IN cord-328396-p2gvpe8i 213 5 conceiving conceive VBG cord-328396-p2gvpe8i 213 6 and and CC cord-328396-p2gvpe8i 213 7 designing design VBG cord-328396-p2gvpe8i 213 8 the the DT cord-328396-p2gvpe8i 213 9 figure figure NN cord-328396-p2gvpe8i 213 10 under under IN cord-328396-p2gvpe8i 213 11 the the DT cord-328396-p2gvpe8i 213 12 supervision supervision NN cord-328396-p2gvpe8i 213 13 from from IN cord-328396-p2gvpe8i 213 14 DT DT NNP cord-328396-p2gvpe8i 213 15 . . . cord-328396-p2gvpe8i 214 1 SK SK NNP cord-328396-p2gvpe8i 214 2 finalized finalize VBD cord-328396-p2gvpe8i 214 3 the the DT cord-328396-p2gvpe8i 214 4 manuscript manuscript NN cord-328396-p2gvpe8i 214 5 . . . cord-328396-p2gvpe8i 215 1 All all DT cord-328396-p2gvpe8i 215 2 authors author NNS cord-328396-p2gvpe8i 215 3 contributed contribute VBD cord-328396-p2gvpe8i 215 4 to to IN cord-328396-p2gvpe8i 215 5 the the DT cord-328396-p2gvpe8i 215 6 article article NN cord-328396-p2gvpe8i 215 7 and and CC cord-328396-p2gvpe8i 215 8 approved approve VBD cord-328396-p2gvpe8i 215 9 the the DT cord-328396-p2gvpe8i 215 10 submitted submit VBN cord-328396-p2gvpe8i 215 11 version version NN cord-328396-p2gvpe8i 215 12 . . . cord-328396-p2gvpe8i 216 1 The the DT cord-328396-p2gvpe8i 216 2 authors author NNS cord-328396-p2gvpe8i 216 3 would would MD cord-328396-p2gvpe8i 216 4 like like VB cord-328396-p2gvpe8i 216 5 to to TO cord-328396-p2gvpe8i 216 6 thank thank VB cord-328396-p2gvpe8i 216 7 Dr. Dr. NNP cord-328396-p2gvpe8i 216 8 Atampreet Atampreet NNP cord-328396-p2gvpe8i 216 9 Singh Singh NNP cord-328396-p2gvpe8i 216 10 ( ( -LRB- cord-328396-p2gvpe8i 216 11 Department Department NNP cord-328396-p2gvpe8i 216 12 of of IN cord-328396-p2gvpe8i 216 13 Neurology Neurology NNP cord-328396-p2gvpe8i 216 14 , , , cord-328396-p2gvpe8i 216 15 Fortis Fortis NNP cord-328396-p2gvpe8i 216 16 Hospital Hospital NNP cord-328396-p2gvpe8i 216 17 , , , cord-328396-p2gvpe8i 216 18 Noida Noida NNP cord-328396-p2gvpe8i 216 19 , , , cord-328396-p2gvpe8i 216 20 India India NNP cord-328396-p2gvpe8i 216 21 ) ) -RRB- cord-328396-p2gvpe8i 216 22 for for IN cord-328396-p2gvpe8i 216 23 his -PRON- PRP$ cord-328396-p2gvpe8i 216 24 valuable valuable JJ cord-328396-p2gvpe8i 216 25 inputs input NNS cord-328396-p2gvpe8i 216 26 and and CC cord-328396-p2gvpe8i 216 27 discussions discussion NNS cord-328396-p2gvpe8i 216 28 while while IN cord-328396-p2gvpe8i 216 29 writing write VBG cord-328396-p2gvpe8i 216 30 of of IN cord-328396-p2gvpe8i 216 31 this this DT cord-328396-p2gvpe8i 216 32 manuscript manuscript NN cord-328396-p2gvpe8i 216 33 . . .