id sid tid token lemma pos cord-347871-w6274bdg 1 1 key key JJ cord-347871-w6274bdg 2 1 : : : cord-347871-w6274bdg 2 2 cord-347871-w6274bdg cord-347871-w6274bdg NNP cord-347871-w6274bdg 2 3 authors author NNS cord-347871-w6274bdg 2 4 : : : cord-347871-w6274bdg 2 5 Kloc Kloc NNP cord-347871-w6274bdg 2 6 , , , cord-347871-w6274bdg 2 7 Malgorzata Malgorzata NNP cord-347871-w6274bdg 2 8 ; ; : cord-347871-w6274bdg 2 9 Ghobrial Ghobrial NNP cord-347871-w6274bdg 2 10 , , , cord-347871-w6274bdg 2 11 Rafik Rafik NNP cord-347871-w6274bdg 2 12 M. M. NNP cord-347871-w6274bdg 3 1 title title NN cord-347871-w6274bdg 3 2 : : : cord-347871-w6274bdg 4 1 The the DT cord-347871-w6274bdg 4 2 multiple multiple JJ cord-347871-w6274bdg 4 3 sclerosis sclerosis NN cord-347871-w6274bdg 4 4 ( ( -LRB- cord-347871-w6274bdg 4 5 MS MS NNP cord-347871-w6274bdg 4 6 ) ) -RRB- cord-347871-w6274bdg 4 7 drugs drug NNS cord-347871-w6274bdg 4 8 as as IN cord-347871-w6274bdg 4 9 a a DT cord-347871-w6274bdg 4 10 potential potential JJ cord-347871-w6274bdg 4 11 treatment treatment NN cord-347871-w6274bdg 4 12 of of IN cord-347871-w6274bdg 4 13 ARDS ARDS NNP cord-347871-w6274bdg 4 14 in in IN cord-347871-w6274bdg 4 15 COVID-19 COVID-19 NNP cord-347871-w6274bdg 4 16 patients patient NNS cord-347871-w6274bdg 4 17 date date NN cord-347871-w6274bdg 4 18 : : : cord-347871-w6274bdg 4 19 2020 2020 CD cord-347871-w6274bdg 4 20 - - HYPH cord-347871-w6274bdg 4 21 07 07 CD cord-347871-w6274bdg 4 22 - - HYPH cord-347871-w6274bdg 4 23 31 31 CD cord-347871-w6274bdg 4 24 journal journal NN cord-347871-w6274bdg 4 25 : : : cord-347871-w6274bdg 5 1 Mult Mult NNP cord-347871-w6274bdg 5 2 Scler Scler NNP cord-347871-w6274bdg 5 3 Relat Relat NNP cord-347871-w6274bdg 5 4 Disord Disord NNP cord-347871-w6274bdg 5 5 DOI doi NN cord-347871-w6274bdg 5 6 : : : cord-347871-w6274bdg 5 7 10.1016/ 10.1016/ CD cord-347871-w6274bdg 6 1 j.msard.2020.102437 j.msard.2020.102437 NNP cord-347871-w6274bdg 6 2 sha sha NNP cord-347871-w6274bdg 6 3 : : : cord-347871-w6274bdg 7 1 3ec165a3e102ad19e0379b698a7ae89ee5d1477e 3ec165a3e102ad19e0379b698a7ae89ee5d1477e NNP cord-347871-w6274bdg 7 2 doc_id doc_id CD cord-347871-w6274bdg 7 3 : : : cord-347871-w6274bdg 7 4 347871 347871 CD cord-347871-w6274bdg 7 5 cord_uid cord_uid NNS cord-347871-w6274bdg 7 6 : : : cord-347871-w6274bdg 7 7 w6274bdg w6274bdg CD cord-347871-w6274bdg 8 1 We -PRON- PRP cord-347871-w6274bdg 8 2 encourage encourage VBP cord-347871-w6274bdg 8 3 studies study NNS cord-347871-w6274bdg 8 4 on on IN cord-347871-w6274bdg 8 5 the the DT cord-347871-w6274bdg 8 6 effectiveness effectiveness NN cord-347871-w6274bdg 8 7 of of IN cord-347871-w6274bdg 8 8 multiple multiple JJ cord-347871-w6274bdg 8 9 sclerosis sclerosis NN cord-347871-w6274bdg 8 10 drugs drug NNS cord-347871-w6274bdg 8 11 for for IN cord-347871-w6274bdg 8 12 the the DT cord-347871-w6274bdg 8 13 treatment treatment NN cord-347871-w6274bdg 8 14 of of IN cord-347871-w6274bdg 8 15 ARDS ARDS NNP cord-347871-w6274bdg 8 16 in in IN cord-347871-w6274bdg 8 17 COVID-19 COVID-19 NNP cord-347871-w6274bdg 8 18 infection infection NN cord-347871-w6274bdg 8 19 . . . cord-347871-w6274bdg 9 1 These these DT cord-347871-w6274bdg 9 2 drugs drug NNS cord-347871-w6274bdg 9 3 , , , cord-347871-w6274bdg 9 4 through through IN cord-347871-w6274bdg 9 5 the the DT cord-347871-w6274bdg 9 6 inhibition inhibition NN cord-347871-w6274bdg 9 7 of of IN cord-347871-w6274bdg 9 8 the the DT cord-347871-w6274bdg 9 9 RhoA RhoA NNP cord-347871-w6274bdg 9 10 / / SYM cord-347871-w6274bdg 9 11 actin actin NN cord-347871-w6274bdg 9 12 - - HYPH cord-347871-w6274bdg 9 13 dependent dependent JJ cord-347871-w6274bdg 9 14 expression expression NN cord-347871-w6274bdg 9 15 of of IN cord-347871-w6274bdg 9 16 virus virus NN cord-347871-w6274bdg 9 17 receptors receptor NNS cord-347871-w6274bdg 9 18 in in IN cord-347871-w6274bdg 9 19 the the DT cord-347871-w6274bdg 9 20 macrophages macrophage NNS cord-347871-w6274bdg 9 21 and and CC cord-347871-w6274bdg 9 22 macrophage macrophage NN cord-347871-w6274bdg 9 23 recruitment recruitment NN cord-347871-w6274bdg 9 24 to to IN cord-347871-w6274bdg 9 25 the the DT cord-347871-w6274bdg 9 26 lungs lung NNS cord-347871-w6274bdg 9 27 , , , cord-347871-w6274bdg 9 28 have have VBP cord-347871-w6274bdg 9 29 the the DT cord-347871-w6274bdg 9 30 potential potential NN cord-347871-w6274bdg 9 31 to to TO cord-347871-w6274bdg 9 32 inhibit inhibit VB cord-347871-w6274bdg 9 33 cytokine cytokine JJ cord-347871-w6274bdg 9 34 storm storm NN cord-347871-w6274bdg 9 35 of of IN cord-347871-w6274bdg 9 36 long long JJ cord-347871-w6274bdg 9 37 macrophages macrophage NNS cord-347871-w6274bdg 9 38 , , , cord-347871-w6274bdg 9 39 reduce reduce VB cord-347871-w6274bdg 9 40 or or CC cord-347871-w6274bdg 9 41 eliminate eliminate VB cord-347871-w6274bdg 9 42 ARDS ARDS NNP cord-347871-w6274bdg 9 43 and and CC cord-347871-w6274bdg 9 44 improve improve VB cord-347871-w6274bdg 9 45 the the DT cord-347871-w6274bdg 9 46 outcome outcome NN cord-347871-w6274bdg 9 47 of of IN cord-347871-w6274bdg 9 48 COVID-19 covid-19 JJ cord-347871-w6274bdg 9 49 infection infection NN cord-347871-w6274bdg 9 50 . . . cord-347871-w6274bdg 10 1 improve improve VB cord-347871-w6274bdg 10 2 the the DT cord-347871-w6274bdg 10 3 outcome outcome NN cord-347871-w6274bdg 10 4 of of IN cord-347871-w6274bdg 10 5 COVID-19 covid-19 JJ cord-347871-w6274bdg 10 6 infection infection NN cord-347871-w6274bdg 10 7 . . . cord-347871-w6274bdg 11 1 The the DT cord-347871-w6274bdg 11 2 main main JJ cord-347871-w6274bdg 11 3 and and CC cord-347871-w6274bdg 11 4 most most RBS cord-347871-w6274bdg 11 5 deadly deadly JJ cord-347871-w6274bdg 11 6 symptom symptom NN cord-347871-w6274bdg 11 7 of of IN cord-347871-w6274bdg 11 8 the the DT cord-347871-w6274bdg 11 9 SARS SARS NNP cord-347871-w6274bdg 11 10 - - HYPH cord-347871-w6274bdg 11 11 CoV-2 CoV-2 NNP cord-347871-w6274bdg 11 12 infection infection NN cord-347871-w6274bdg 11 13 is be VBZ cord-347871-w6274bdg 11 14 acute acute JJ cord-347871-w6274bdg 11 15 respiratory respiratory JJ cord-347871-w6274bdg 11 16 distress distress NN cord-347871-w6274bdg 11 17 syndrome syndrome NN cord-347871-w6274bdg 11 18 ( ( -LRB- cord-347871-w6274bdg 11 19 ARDS ARDS NNP cord-347871-w6274bdg 11 20 ) ) -RRB- cord-347871-w6274bdg 11 21 in in IN cord-347871-w6274bdg 11 22 the the DT cord-347871-w6274bdg 11 23 lungs lung NNS cord-347871-w6274bdg 11 24 of of IN cord-347871-w6274bdg 11 25 COVID-19 covid-19 CD cord-347871-w6274bdg 11 26 patients patient NNS cord-347871-w6274bdg 11 27 . . . cord-347871-w6274bdg 12 1 ARDS ARDS NNP cord-347871-w6274bdg 12 2 is be VBZ cord-347871-w6274bdg 12 3 caused cause VBN cord-347871-w6274bdg 12 4 by by IN cord-347871-w6274bdg 12 5 the the DT cord-347871-w6274bdg 12 6 hyperactive hyperactive JJ cord-347871-w6274bdg 12 7 immune immune JJ cord-347871-w6274bdg 12 8 response response NN cord-347871-w6274bdg 12 9 and and CC cord-347871-w6274bdg 12 10 the the DT cord-347871-w6274bdg 12 11 production production NN cord-347871-w6274bdg 12 12 of of IN cord-347871-w6274bdg 12 13 cytokine cytokine NN cord-347871-w6274bdg 12 14 storm storm NN cord-347871-w6274bdg 12 15 by by IN cord-347871-w6274bdg 12 16 the the DT cord-347871-w6274bdg 12 17 lung lung NN cord-347871-w6274bdg 12 18 macrophages macrophage NNS cord-347871-w6274bdg 12 19 . . . cord-347871-w6274bdg 13 1 The the DT cord-347871-w6274bdg 13 2 entry entry NN cord-347871-w6274bdg 13 3 of of IN cord-347871-w6274bdg 13 4 the the DT cord-347871-w6274bdg 13 5 virus virus NN cord-347871-w6274bdg 13 6 to to IN cord-347871-w6274bdg 13 7 the the DT cord-347871-w6274bdg 13 8 lung lung NN cord-347871-w6274bdg 13 9 epithelial epithelial NN cord-347871-w6274bdg 13 10 cells cell NNS cord-347871-w6274bdg 13 11 and and CC cord-347871-w6274bdg 13 12 lung lung NN cord-347871-w6274bdg 13 13 macrophages macrophage NNS cord-347871-w6274bdg 13 14 depends depend VBZ cord-347871-w6274bdg 13 15 on on IN cord-347871-w6274bdg 13 16 the the DT cord-347871-w6274bdg 13 17 ACE2 ACE2 NNP cord-347871-w6274bdg 13 18 receptor receptor NN cord-347871-w6274bdg 13 19 expressed express VBN cord-347871-w6274bdg 13 20 on on IN cord-347871-w6274bdg 13 21 the the DT cord-347871-w6274bdg 13 22 surface surface NN cord-347871-w6274bdg 13 23 of of IN cord-347871-w6274bdg 13 24 these these DT cord-347871-w6274bdg 13 25 cells cell NNS cord-347871-w6274bdg 13 26 . . . cord-347871-w6274bdg 14 1 The the DT cord-347871-w6274bdg 14 2 immune immune JJ cord-347871-w6274bdg 14 3 factors factor NNS cord-347871-w6274bdg 14 4 ( ( -LRB- cord-347871-w6274bdg 14 5 cytokines cytokine NNS cord-347871-w6274bdg 14 6 and and CC cord-347871-w6274bdg 14 7 chemokines chemokine NNS cord-347871-w6274bdg 14 8 ) ) -RRB- cord-347871-w6274bdg 14 9 released release VBN cord-347871-w6274bdg 14 10 from from IN cord-347871-w6274bdg 14 11 the the DT cord-347871-w6274bdg 14 12 infected infected JJ cord-347871-w6274bdg 14 13 cells cell NNS cord-347871-w6274bdg 14 14 recruit recruit VBP cord-347871-w6274bdg 14 15 additional additional JJ cord-347871-w6274bdg 14 16 immune immune JJ cord-347871-w6274bdg 14 17 cells cell NNS cord-347871-w6274bdg 14 18 , , , cord-347871-w6274bdg 14 19 including include VBG cord-347871-w6274bdg 14 20 monocytes monocyte NNS cord-347871-w6274bdg 14 21 and and CC cord-347871-w6274bdg 14 22 macrophages macrophage NNS cord-347871-w6274bdg 14 23 from from IN cord-347871-w6274bdg 14 24 the the DT cord-347871-w6274bdg 14 25 bone bone NN cord-347871-w6274bdg 14 26 marrow marrow NN cord-347871-w6274bdg 14 27 and and CC cord-347871-w6274bdg 14 28 blood blood NN cord-347871-w6274bdg 14 29 , , , cord-347871-w6274bdg 14 30 to to TO cord-347871-w6274bdg 14 31 join join VB cord-347871-w6274bdg 14 32 the the DT cord-347871-w6274bdg 14 33 fight fight NN cord-347871-w6274bdg 14 34 against against IN cord-347871-w6274bdg 14 35 infection infection NN cord-347871-w6274bdg 14 36 . . . cord-347871-w6274bdg 15 1 This this DT cord-347871-w6274bdg 15 2 avalanche avalanche NN cord-347871-w6274bdg 15 3 ( ( -LRB- cord-347871-w6274bdg 15 4 cytokine cytokine NN cord-347871-w6274bdg 15 5 storm storm NN cord-347871-w6274bdg 15 6 ) ) -RRB- cord-347871-w6274bdg 15 7 of of IN cord-347871-w6274bdg 15 8 immune immune JJ cord-347871-w6274bdg 15 9 factors factor NNS cord-347871-w6274bdg 15 10 is be VBZ cord-347871-w6274bdg 15 11 extremely extremely RB cord-347871-w6274bdg 15 12 damaging damaging JJ cord-347871-w6274bdg 15 13 for for IN cord-347871-w6274bdg 15 14 the the DT cord-347871-w6274bdg 15 15 lung lung NN cord-347871-w6274bdg 15 16 tissues tissue NNS cord-347871-w6274bdg 15 17 and and CC cord-347871-w6274bdg 15 18 , , , cord-347871-w6274bdg 15 19 ultimately ultimately RB cord-347871-w6274bdg 15 20 , , , cord-347871-w6274bdg 15 21 leads lead VBZ cord-347871-w6274bdg 15 22 to to IN cord-347871-w6274bdg 15 23 lung lung NN cord-347871-w6274bdg 15 24 failure failure NN cord-347871-w6274bdg 15 25 ( ( -LRB- cord-347871-w6274bdg 15 26 1 1 CD cord-347871-w6274bdg 15 27 - - SYM cord-347871-w6274bdg 15 28 7 7 CD cord-347871-w6274bdg 15 29 ) ) -RRB- cord-347871-w6274bdg 15 30 . . . cord-347871-w6274bdg 16 1 Thus thus RB cord-347871-w6274bdg 16 2 , , , cord-347871-w6274bdg 16 3 the the DT cord-347871-w6274bdg 16 4 potential potential JJ cord-347871-w6274bdg 16 5 drugs drug NNS cord-347871-w6274bdg 16 6 which which WDT cord-347871-w6274bdg 16 7 could could MD cord-347871-w6274bdg 16 8 reduce reduce VB cord-347871-w6274bdg 16 9 or or CC cord-347871-w6274bdg 16 10 eliminate eliminate VB cord-347871-w6274bdg 16 11 ARDS ARDS NNP cord-347871-w6274bdg 16 12 should should MD cord-347871-w6274bdg 16 13 be be VB cord-347871-w6274bdg 16 14 targeting target VBG cord-347871-w6274bdg 16 15 the the DT cord-347871-w6274bdg 16 16 ACE2 ACE2 NNP cord-347871-w6274bdg 16 17 receptors receptor NNS cord-347871-w6274bdg 16 18 and and CC cord-347871-w6274bdg 16 19 macrophage macrophage NN cord-347871-w6274bdg 16 20 response response NN cord-347871-w6274bdg 16 21 . . . cord-347871-w6274bdg 17 1 Research research NN cord-347871-w6274bdg 17 2 in in IN cord-347871-w6274bdg 17 3 our -PRON- PRP$ cord-347871-w6274bdg 17 4 laboratory laboratory NN cord-347871-w6274bdg 17 5 has have VBZ cord-347871-w6274bdg 17 6 been be VBN cord-347871-w6274bdg 17 7 , , , cord-347871-w6274bdg 17 8 for for IN cord-347871-w6274bdg 17 9 years year NNS cord-347871-w6274bdg 17 10 , , , cord-347871-w6274bdg 17 11 focused focus VBD cord-347871-w6274bdg 17 12 on on IN cord-347871-w6274bdg 17 13 the the DT cord-347871-w6274bdg 17 14 prevention prevention NN cord-347871-w6274bdg 17 15 of of IN cord-347871-w6274bdg 17 16 long long JJ cord-347871-w6274bdg 17 17 term term NN cord-347871-w6274bdg 17 18 ( ( -LRB- cord-347871-w6274bdg 17 19 chronic chronic JJ cord-347871-w6274bdg 17 20 rejection rejection NN cord-347871-w6274bdg 17 21 ) ) -RRB- cord-347871-w6274bdg 17 22 of of IN cord-347871-w6274bdg 17 23 transplanted transplanted JJ cord-347871-w6274bdg 17 24 organs organ NNS cord-347871-w6274bdg 17 25 . . . cord-347871-w6274bdg 18 1 During during IN cord-347871-w6274bdg 18 2 these these DT cord-347871-w6274bdg 18 3 studies study NNS cord-347871-w6274bdg 18 4 , , , cord-347871-w6274bdg 18 5 we -PRON- PRP cord-347871-w6274bdg 18 6 showed show VBD cord-347871-w6274bdg 18 7 that that IN cord-347871-w6274bdg 18 8 chronic chronic JJ cord-347871-w6274bdg 18 9 rejection rejection NN cord-347871-w6274bdg 18 10 depends depend VBZ cord-347871-w6274bdg 18 11 on on IN cord-347871-w6274bdg 18 12 the the DT cord-347871-w6274bdg 18 13 macrophage macrophage NN cord-347871-w6274bdg 18 14 entry entry NN cord-347871-w6274bdg 18 15 into into IN cord-347871-w6274bdg 18 16 the the DT cord-347871-w6274bdg 18 17 allograft allograft NN cord-347871-w6274bdg 18 18 and and CC cord-347871-w6274bdg 18 19 that that IN cord-347871-w6274bdg 18 20 the the DT cord-347871-w6274bdg 18 21 application application NN cord-347871-w6274bdg 18 22 of of IN cord-347871-w6274bdg 18 23 the the DT cord-347871-w6274bdg 18 24 inhibitors inhibitor NNS cord-347871-w6274bdg 18 25 of of IN cord-347871-w6274bdg 18 26 small small JJ cord-347871-w6274bdg 18 27 GTPase GTPase NNP cord-347871-w6274bdg 18 28 RhoA RhoA NNP cord-347871-w6274bdg 18 29 pathway pathway NN cord-347871-w6274bdg 18 30 prevents prevent VBZ cord-347871-w6274bdg 18 31 macrophage macrophage NN cord-347871-w6274bdg 18 32 infiltration infiltration NN cord-347871-w6274bdg 18 33 and and CC cord-347871-w6274bdg 18 34 inhibits inhibit VBZ cord-347871-w6274bdg 18 35 chronic chronic JJ cord-347871-w6274bdg 18 36 rejection rejection NN cord-347871-w6274bdg 18 37 ( ( -LRB- cord-347871-w6274bdg 18 38 8) 8) NNP cord-347871-w6274bdg 18 39 ( ( -LRB- cord-347871-w6274bdg 18 40 9 9 CD cord-347871-w6274bdg 18 41 ) ) -RRB- cord-347871-w6274bdg 18 42 ( ( -LRB- cord-347871-w6274bdg 18 43 10 10 CD cord-347871-w6274bdg 18 44 ) ) -RRB- cord-347871-w6274bdg 18 45 . . . cord-347871-w6274bdg 19 1 The the DT cord-347871-w6274bdg 19 2 RhoA RhoA NNP cord-347871-w6274bdg 19 3 pathway pathway NN cord-347871-w6274bdg 19 4 regulates regulate VBZ cord-347871-w6274bdg 19 5 actin actin NN cord-347871-w6274bdg 19 6 cytoskeleton cytoskeleton NN cord-347871-w6274bdg 19 7 in in IN cord-347871-w6274bdg 19 8 all all DT cord-347871-w6274bdg 19 9 eukaryotic eukaryotic JJ cord-347871-w6274bdg 19 10 cells cell NNS cord-347871-w6274bdg 19 11 , , , cord-347871-w6274bdg 19 12 and and CC cord-347871-w6274bdg 19 13 as as IN cord-347871-w6274bdg 19 14 such such JJ cord-347871-w6274bdg 19 15 also also RB cord-347871-w6274bdg 19 16 regulates regulate VBZ cord-347871-w6274bdg 19 17 actin actin NN cord-347871-w6274bdg 19 18 - - HYPH cord-347871-w6274bdg 19 19 dependent dependent JJ cord-347871-w6274bdg 19 20 cell cell NN cord-347871-w6274bdg 19 21 movement movement NN cord-347871-w6274bdg 19 22 and and CC cord-347871-w6274bdg 19 23 recycling recycling NN cord-347871-w6274bdg 19 24 and and CC cord-347871-w6274bdg 19 25 expression expression NN cord-347871-w6274bdg 19 26 of of IN cord-347871-w6274bdg 19 27 macrophage macrophage NN cord-347871-w6274bdg 19 28 receptors receptor NNS cord-347871-w6274bdg 19 29 , , , cord-347871-w6274bdg 19 30 which which WDT cord-347871-w6274bdg 19 31 home home NN cord-347871-w6274bdg 19 32 macrophages macrophage NNS cord-347871-w6274bdg 19 33 to to IN cord-347871-w6274bdg 19 34 the the DT cord-347871-w6274bdg 19 35 graft graft NN cord-347871-w6274bdg 19 36 . . . cord-347871-w6274bdg 20 1 In in IN cord-347871-w6274bdg 20 2 our -PRON- PRP$ cord-347871-w6274bdg 20 3 search search NN cord-347871-w6274bdg 20 4 for for IN cord-347871-w6274bdg 20 5 clinically clinically RB cord-347871-w6274bdg 20 6 applicable applicable JJ cord-347871-w6274bdg 20 7 RhoA RhoA NNP cord-347871-w6274bdg 20 8 pathway pathway NN cord-347871-w6274bdg 20 9 inhibitors inhibitor NNS cord-347871-w6274bdg 20 10 we -PRON- PRP cord-347871-w6274bdg 20 11 found find VBD cord-347871-w6274bdg 20 12 that that IN cord-347871-w6274bdg 20 13 drugs drug NNS cord-347871-w6274bdg 20 14 clinically clinically RB cord-347871-w6274bdg 20 15 approved approve VBN cord-347871-w6274bdg 20 16 for for IN cord-347871-w6274bdg 20 17 the the DT cord-347871-w6274bdg 20 18 treatment treatment NN cord-347871-w6274bdg 20 19 of of IN cord-347871-w6274bdg 20 20 multiple multiple JJ cord-347871-w6274bdg 20 21 sclerosis sclerosis NN cord-347871-w6274bdg 20 22 ( ( -LRB- cord-347871-w6274bdg 20 23 MS MS NNP cord-347871-w6274bdg 20 24 ) ) -RRB- cord-347871-w6274bdg 20 25 , , , cord-347871-w6274bdg 20 26 Fingolimod Fingolimod NNP cord-347871-w6274bdg 20 27 and and CC cord-347871-w6274bdg 20 28 Siponimod Siponimod NNP cord-347871-w6274bdg 20 29 , , , cord-347871-w6274bdg 20 30 also also RB cord-347871-w6274bdg 20 31 inhibit inhibit VB cord-347871-w6274bdg 20 32 RhoA RhoA NNP cord-347871-w6274bdg 20 33 and and CC cord-347871-w6274bdg 20 34 RhoA RhoA NNP cord-347871-w6274bdg 20 35 / / SYM cord-347871-w6274bdg 20 36 actin actin NN cord-347871-w6274bdg 20 37 - - HYPH cord-347871-w6274bdg 20 38 dependent dependent JJ cord-347871-w6274bdg 20 39 macrophage macrophage NN cord-347871-w6274bdg 20 40 receptors receptor NNS cord-347871-w6274bdg 20 41 recycling recycle VBG cord-347871-w6274bdg 20 42 , , , cord-347871-w6274bdg 20 43 and and CC cord-347871-w6274bdg 20 44 expression expression NN cord-347871-w6274bdg 20 45 , , , cord-347871-w6274bdg 20 46 and and CC cord-347871-w6274bdg 20 47 can can MD cord-347871-w6274bdg 20 48 be be VB cord-347871-w6274bdg 20 49 potentially potentially RB cord-347871-w6274bdg 20 50 used use VBN cord-347871-w6274bdg 20 51 as as IN cord-347871-w6274bdg 20 52 an an DT cord-347871-w6274bdg 20 53 anti anti JJ cord-347871-w6274bdg 20 54 - - JJ cord-347871-w6274bdg 20 55 chronic chronic JJ cord-347871-w6274bdg 20 56 rejection rejection NN cord-347871-w6274bdg 20 57 therapy therapy NN cord-347871-w6274bdg 20 58 in in IN cord-347871-w6274bdg 20 59 human human JJ cord-347871-w6274bdg 20 60 transplantation transplantation NN cord-347871-w6274bdg 20 61 ( ( -LRB- cord-347871-w6274bdg 20 62 11 11 CD cord-347871-w6274bdg 20 63 , , , cord-347871-w6274bdg 20 64 12 12 CD cord-347871-w6274bdg 20 65 ) ) -RRB- cord-347871-w6274bdg 20 66 . . . cord-347871-w6274bdg 21 1 Our -PRON- PRP$ cord-347871-w6274bdg 21 2 center center NN cord-347871-w6274bdg 21 3 is be VBZ cord-347871-w6274bdg 21 4 initiating initiate VBG cord-347871-w6274bdg 21 5 the the DT cord-347871-w6274bdg 21 6 clinical clinical JJ cord-347871-w6274bdg 21 7 trial trial NN cord-347871-w6274bdg 21 8 on on IN cord-347871-w6274bdg 21 9 the the DT cord-347871-w6274bdg 21 10 effect effect NN cord-347871-w6274bdg 21 11 of of IN cord-347871-w6274bdg 21 12 Fingolimod Fingolimod NNP cord-347871-w6274bdg 21 13 in in IN cord-347871-w6274bdg 21 14 kidney kidney NN cord-347871-w6274bdg 21 15 transplantation transplantation NN cord-347871-w6274bdg 21 16 patients patient NNS cord-347871-w6274bdg 21 17 . . . cord-347871-w6274bdg 22 1 Because because IN cord-347871-w6274bdg 22 2 these these DT cord-347871-w6274bdg 22 3 clinically clinically RB cord-347871-w6274bdg 22 4 approved approve VBN cord-347871-w6274bdg 22 5 drugs drug NNS cord-347871-w6274bdg 22 6 inhibit inhibit VBP cord-347871-w6274bdg 22 7 , , , cord-347871-w6274bdg 22 8 via via IN cord-347871-w6274bdg 22 9 RhoA/ RhoA/ NNP cord-347871-w6274bdg 22 10 actin actin NNP cord-347871-w6274bdg 22 11 pathway pathway NN cord-347871-w6274bdg 22 12 , , , cord-347871-w6274bdg 22 13 macrophage macrophage NN cord-347871-w6274bdg 22 14 movement movement NN cord-347871-w6274bdg 22 15 , , , cord-347871-w6274bdg 22 16 and and CC cord-347871-w6274bdg 22 17 expression expression NN cord-347871-w6274bdg 22 18 of of IN cord-347871-w6274bdg 22 19 macrophage macrophage NN cord-347871-w6274bdg 22 20 receptors receptor NNS cord-347871-w6274bdg 22 21 , , , cord-347871-w6274bdg 22 22 they -PRON- PRP cord-347871-w6274bdg 22 23 have have VBP cord-347871-w6274bdg 22 24 also also RB cord-347871-w6274bdg 22 25 a a DT cord-347871-w6274bdg 22 26 potential potential NN cord-347871-w6274bdg 22 27 to to TO cord-347871-w6274bdg 22 28 inhibit inhibit VB cord-347871-w6274bdg 22 29 ACE2 ACE2 NNP cord-347871-w6274bdg 22 30 receptors receptor NNS cord-347871-w6274bdg 22 31 expression expression NN cord-347871-w6274bdg 22 32 and and CC cord-347871-w6274bdg 22 33 the the DT cord-347871-w6274bdg 22 34 recruitment recruitment NN cord-347871-w6274bdg 22 35 of of IN cord-347871-w6274bdg 22 36 macrophages macrophage NNS cord-347871-w6274bdg 22 37 to to IN cord-347871-w6274bdg 22 38 the the DT cord-347871-w6274bdg 22 39 lungs lung NNS cord-347871-w6274bdg 22 40 of of IN cord-347871-w6274bdg 22 41 the the DT cord-347871-w6274bdg 22 42 COVId-19 COVId-19 NNP cord-347871-w6274bdg 22 43 patients patient NNS cord-347871-w6274bdg 22 44 , , , cord-347871-w6274bdg 22 45 which which WDT cord-347871-w6274bdg 22 46 in in IN cord-347871-w6274bdg 22 47 turn turn NN cord-347871-w6274bdg 22 48 would would MD cord-347871-w6274bdg 22 49 decrease decrease VB cord-347871-w6274bdg 22 50 cytokine cytokine JJ cord-347871-w6274bdg 22 51 storm storm NN cord-347871-w6274bdg 22 52 and and CC cord-347871-w6274bdg 22 53 attenuate attenuate VB cord-347871-w6274bdg 22 54 ARDS ARDS NNP cord-347871-w6274bdg 22 55 . . . cord-347871-w6274bdg 22 56 _SP cord-347871-w6274bdg 23 1 Editorial editorial NN cord-347871-w6274bdg 23 2 : : : cord-347871-w6274bdg 24 1 Alveolar alveolar NN cord-347871-w6274bdg 24 2 Macrophages Macrophages NNP cord-347871-w6274bdg 24 3 in in IN cord-347871-w6274bdg 24 4 Lung Lung NNP cord-347871-w6274bdg 24 5 Inflammation Inflammation NNP cord-347871-w6274bdg 24 6 and and CC cord-347871-w6274bdg 24 7 Resolution Resolution NNP cord-347871-w6274bdg 24 8 Alveolar Alveolar NNP cord-347871-w6274bdg 24 9 macrophages macrophage NNS cord-347871-w6274bdg 25 1 Alveolar alveolar NN cord-347871-w6274bdg 25 2 macrophages macrophage NNS cord-347871-w6274bdg 25 3 : : : cord-347871-w6274bdg 26 1 plasticity plasticity NN cord-347871-w6274bdg 26 2 in in IN cord-347871-w6274bdg 26 3 a a DT cord-347871-w6274bdg 26 4 tissue tissue NN cord-347871-w6274bdg 26 5 - - HYPH cord-347871-w6274bdg 26 6 specific specific JJ cord-347871-w6274bdg 26 7 context context NN cord-347871-w6274bdg 26 8 Cytokine cytokine NN cord-347871-w6274bdg 26 9 Storm Storm NNP cord-347871-w6274bdg 26 10 in in IN cord-347871-w6274bdg 26 11 COVID-19 COVID-19 NNP cord-347871-w6274bdg 26 12 and and CC cord-347871-w6274bdg 26 13 Treatment Treatment NNP cord-347871-w6274bdg 26 14 Triptolide Triptolide NNP cord-347871-w6274bdg 26 15 mitigates mitigate VBZ cord-347871-w6274bdg 26 16 radiation radiation NN cord-347871-w6274bdg 26 17 - - HYPH cord-347871-w6274bdg 26 18 induced induce VBN cord-347871-w6274bdg 26 19 pneumonitis pneumonitis NN cord-347871-w6274bdg 26 20 via via IN cord-347871-w6274bdg 26 21 inhibition inhibition NN cord-347871-w6274bdg 26 22 of of IN cord-347871-w6274bdg 26 23 alveolar alveolar JJ cord-347871-w6274bdg 26 24 macrophages macrophage NNS cord-347871-w6274bdg 26 25 and and CC cord-347871-w6274bdg 26 26 related relate VBN cord-347871-w6274bdg 26 27 inflammatory inflammatory JJ cord-347871-w6274bdg 26 28 molecules molecule NNS cord-347871-w6274bdg 27 1 Alveolar Alveolar NNP cord-347871-w6274bdg 27 2 Macrophage Macrophage NNP cord-347871-w6274bdg 27 3 Activation Activation NNP cord-347871-w6274bdg 27 4 and and CC cord-347871-w6274bdg 27 5 Cytokine Cytokine NNP cord-347871-w6274bdg 27 6 Storm storm NN cord-347871-w6274bdg 27 7 in in IN cord-347871-w6274bdg 27 8 the the DT cord-347871-w6274bdg 27 9 Pathogenesis Pathogenesis NNP cord-347871-w6274bdg 27 10 of of IN cord-347871-w6274bdg 27 11 Severe Severe NNP cord-347871-w6274bdg 27 12 COVID-19 COVID-19 NNP cord-347871-w6274bdg 27 13 Structural structural JJ cord-347871-w6274bdg 27 14 basis basis NN cord-347871-w6274bdg 27 15 for for IN cord-347871-w6274bdg 27 16 the the DT cord-347871-w6274bdg 27 17 recognition recognition NN cord-347871-w6274bdg 27 18 of of IN cord-347871-w6274bdg 27 19 SARS SARS NNP cord-347871-w6274bdg 27 20 - - HYPH cord-347871-w6274bdg 27 21 CoV-2 CoV-2 NNP cord-347871-w6274bdg 27 22 by by IN cord-347871-w6274bdg 27 23 full full JJ cord-347871-w6274bdg 27 24 - - HYPH cord-347871-w6274bdg 27 25 length length NN cord-347871-w6274bdg 27 26 human human JJ cord-347871-w6274bdg 27 27 ACE2 ACE2 NNP cord-347871-w6274bdg 27 28 Macrophage Macrophage NNP cord-347871-w6274bdg 27 29 / / SYM cord-347871-w6274bdg 27 30 monocyte monocyte NN cord-347871-w6274bdg 27 31 - - HYPH cord-347871-w6274bdg 27 32 specific specific JJ cord-347871-w6274bdg 27 33 deletion deletion NN cord-347871-w6274bdg 27 34 of of IN cord-347871-w6274bdg 27 35 RhoA RhoA NNP cord-347871-w6274bdg 27 36 down down RB cord-347871-w6274bdg 27 37 - - HYPH cord-347871-w6274bdg 27 38 regulates regulate VBZ cord-347871-w6274bdg 27 39 fractalkine fractalkine JJ cord-347871-w6274bdg 27 40 receptor receptor NN cord-347871-w6274bdg 27 41 and and CC cord-347871-w6274bdg 27 42 inhibits inhibit VBZ cord-347871-w6274bdg 27 43 chronic chronic JJ cord-347871-w6274bdg 27 44 rejection rejection NN cord-347871-w6274bdg 27 45 of of IN cord-347871-w6274bdg 27 46 mouse mouse NN cord-347871-w6274bdg 27 47 cardiac cardiac NN cord-347871-w6274bdg 27 48 allografts allograft NNS cord-347871-w6274bdg 27 49 Macrophages Macrophages NNPS cord-347871-w6274bdg 27 50 and and CC cord-347871-w6274bdg 27 51 RhoA RhoA NNP cord-347871-w6274bdg 27 52 Pathway Pathway NNP cord-347871-w6274bdg 27 53 in in IN cord-347871-w6274bdg 27 54 Transplanted transplant VBN cord-347871-w6274bdg 27 55 Organs Organs NNPS cord-347871-w6274bdg 27 56 Screening Screening NNP cord-347871-w6274bdg 27 57 RhoA RhoA NNP cord-347871-w6274bdg 27 58 / / SYM cord-347871-w6274bdg 27 59 ROCK ROCK NNP cord-347871-w6274bdg 27 60 inhibitors inhibitor NNS cord-347871-w6274bdg 27 61 for for IN cord-347871-w6274bdg 27 62 the the DT cord-347871-w6274bdg 27 63 ability ability NN cord-347871-w6274bdg 27 64 to to TO cord-347871-w6274bdg 27 65 prevent prevent VB cord-347871-w6274bdg 27 66 chronic chronic JJ cord-347871-w6274bdg 27 67 rejection rejection NN cord-347871-w6274bdg 27 68 of of IN cord-347871-w6274bdg 27 69 mouse mouse NN cord-347871-w6274bdg 27 70 cardiac cardiac JJ cord-347871-w6274bdg 27 71 allografts allografts NNP cord-347871-w6274bdg 27 72 Inhibition Inhibition NNP cord-347871-w6274bdg 27 73 of of IN cord-347871-w6274bdg 27 74 RhoA RhoA NNP cord-347871-w6274bdg 27 75 and and CC cord-347871-w6274bdg 27 76 mTORC2 mTORC2 NNP cord-347871-w6274bdg 27 77 / / SYM cord-347871-w6274bdg 27 78 Rictor Rictor NNP cord-347871-w6274bdg 27 79 by by IN cord-347871-w6274bdg 27 80 Fingolimod Fingolimod NNP cord-347871-w6274bdg 27 81 ( ( -LRB- cord-347871-w6274bdg 27 82 FTY720 FTY720 NNP cord-347871-w6274bdg 27 83 ) ) -RRB- cord-347871-w6274bdg 27 84 induces induce VBZ cord-347871-w6274bdg 27 85 p21-activated p21-activate VBN cord-347871-w6274bdg 27 86 kinase kinase NN cord-347871-w6274bdg 27 87 1 1 CD cord-347871-w6274bdg 27 88 , , , cord-347871-w6274bdg 27 89 PAK-1 PAK-1 NNP cord-347871-w6274bdg 27 90 and and CC cord-347871-w6274bdg 27 91 amplifies amplify VBZ cord-347871-w6274bdg 27 92 podosomes podosome NNS cord-347871-w6274bdg 27 93 in in IN cord-347871-w6274bdg 27 94 mouse mouse NN cord-347871-w6274bdg 27 95 peritoneal peritoneal NN cord-347871-w6274bdg 27 96 macrophages macrophage NNS cord-347871-w6274bdg 28 1 Siponimod Siponimod NNP cord-347871-w6274bdg 28 2 ( ( -LRB- cord-347871-w6274bdg 28 3 Mayzent Mayzent NNP cord-347871-w6274bdg 28 4 ) ) -RRB- cord-347871-w6274bdg 28 5 Downregulates Downregulates NNP cord-347871-w6274bdg 28 6 RhoA RhoA NNP cord-347871-w6274bdg 28 7 and and CC cord-347871-w6274bdg 28 8 Cell Cell NNP cord-347871-w6274bdg 28 9 Surface Surface NNP cord-347871-w6274bdg 28 10 Expression expression NN cord-347871-w6274bdg 28 11 of of IN cord-347871-w6274bdg 28 12 the the DT cord-347871-w6274bdg 28 13 S1P1 S1P1 NNP cord-347871-w6274bdg 28 14 and and CC cord-347871-w6274bdg 28 15 CX3CR1 CX3CR1 NNP cord-347871-w6274bdg 28 16 Receptors Receptors NNPS cord-347871-w6274bdg 28 17 in in IN cord-347871-w6274bdg 28 18 Mouse Mouse NNP cord-347871-w6274bdg 28 19 RAW raw JJ cord-347871-w6274bdg 28 20 264.7 264.7 CD cord-347871-w6274bdg 29 1 Macrophages macrophage NNS cord-347871-w6274bdg 29 2 Gene gene NN cord-347871-w6274bdg 29 3 signatures signature NNS cord-347871-w6274bdg 29 4 of of IN cord-347871-w6274bdg 29 5 SARS SARS NNP cord-347871-w6274bdg 29 6 - - HYPH cord-347871-w6274bdg 29 7 CoV CoV NNP cord-347871-w6274bdg 29 8 / / SYM cord-347871-w6274bdg 29 9 SARS SARS NNP cord-347871-w6274bdg 29 10 - - HYPH cord-347871-w6274bdg 29 11 CoV-2-infected cov-2-infecte VBN cord-347871-w6274bdg 29 12 ferret ferret JJ cord-347871-w6274bdg 29 13 lungs lung NNS cord-347871-w6274bdg 29 14 in in IN cord-347871-w6274bdg 29 15 short short JJ cord-347871-w6274bdg 29 16 - - HYPH cord-347871-w6274bdg 29 17 and and CC cord-347871-w6274bdg 29 18 long long JJ cord-347871-w6274bdg 29 19 - - HYPH cord-347871-w6274bdg 29 20 term term NN cord-347871-w6274bdg 29 21 models model NNS