id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257244-gryp0khc	Edwards, M. R.	The potential of anti‐infectives and immunomodulators as therapies for asthma and asthma exacerbations	2017-08-10		.txt	text/plain	5746	317	37	Despite these important associations, the use of antiinfectives (antibiotics, antivirals, antifungals, vaccines) that specifically target known pathogens, or drugs that are based on or exploit microbe-host receptor interactions (toll-like receptor agonists, bacterial lysates) or are immunomodulators (vitamin D), and/or may work in part by altering our associated microbiology (probiotics) are, with the exception of severe asthma, seldom considered in asthma treatment, prevention and guidelines. Overall, antibiotic use is associated with asthma risk rather than protection at most stages of human development, including pregnancy, 10, 11 early life 12 and childhood, 13 although why this is so is a subject widely debated. 10 In retrospective studies, the association between antibiotic use and increased risk of asthma or wheezing in children is further confused due to the potential of reverse causation. Inhibiting virus replication through interfering with viral enzymes active within cells poses additional problems in drug discovery; however, several useful inhibitors for respiratory tract viruses have found their way into phase I/II clinical trials.	./cache/cord-257244-gryp0khc.txt	./txt/cord-257244-gryp0khc.txt