id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283870-b9hvcrd1	Castillo, Jamee R.	Asthma Exacerbations: Pathogenesis, Prevention, and Treatment	2017-08-31		.txt	text/plain	5605	358	41	23 Finally, the use of inhaled IFN-b at the time of an upper respiratory infection reduces the airway viral load and improves clinical symptoms in patients with asthma. 50 ICS but under poor control, 50 Pauwels et al showed that highdose budesonide further reduced severe asthma exacerbations, that is, need for systemic corticosteroids, by nearly 50% compared with treatment with low-dose ICS in adults. In 2 replicate trials with a total of 912 adult patients with severe asthma and using ICS/LABA, adding tiotropium, 5 mcg, increased the time to first exacerbation by 56 days over placebo, and reduced exacerbations by 21% ( Figure 5 ). Two anti-IL-5 monoclonal antibodies, mepolizumab and reslizumab, are approved as maintenance therapy for patients with uncontrolled, persistent eosinophilic asthma with an exacerbation phenotype despite high-dose ICS.	./cache/cord-283870-b9hvcrd1.txt	./txt/cord-283870-b9hvcrd1.txt