id sid tid token lemma pos cord-300311-eah49b3g 1 1 key key NN cord-300311-eah49b3g 1 2 : : : cord-300311-eah49b3g 2 1 cord-300311-eah49b3 cord-300311-eah49b3 NNP cord-300311-eah49b3g 2 2 g g NNP cord-300311-eah49b3g 2 3 authors author NNS cord-300311-eah49b3g 2 4 : : : cord-300311-eah49b3g 2 5 Bueving Bueving NNP cord-300311-eah49b3g 2 6 , , , cord-300311-eah49b3g 2 7 Herman Herman NNP cord-300311-eah49b3g 2 8 J. J. NNP cord-300311-eah49b3g 2 9 ; ; : cord-300311-eah49b3g 2 10 van van NNP cord-300311-eah49b3g 2 11 der der NNP cord-300311-eah49b3g 2 12 Wouden Wouden NNP cord-300311-eah49b3g 2 13 , , , cord-300311-eah49b3g 2 14 Johannes Johannes NNP cord-300311-eah49b3g 2 15 C. C. NNP cord-300311-eah49b3g 2 16 title title NN cord-300311-eah49b3g 3 1 : : : cord-300311-eah49b3g 3 2 What what WP cord-300311-eah49b3g 3 3 is be VBZ cord-300311-eah49b3g 3 4 the the DT cord-300311-eah49b3g 3 5 role role NN cord-300311-eah49b3g 3 6 of of IN cord-300311-eah49b3g 3 7 virus virus NN cord-300311-eah49b3g 3 8 vaccination vaccination NN cord-300311-eah49b3g 3 9 in in IN cord-300311-eah49b3g 3 10 patients patient NNS cord-300311-eah49b3g 3 11 with with IN cord-300311-eah49b3g 3 12 asthma asthma NN cord-300311-eah49b3g 3 13 ? ? . cord-300311-eah49b3g 4 1 date date NN cord-300311-eah49b3g 4 2 : : : cord-300311-eah49b3g 4 3 2007 2007 CD cord-300311-eah49b3g 4 4 - - SYM cord-300311-eah49b3g 4 5 05 05 CD cord-300311-eah49b3g 4 6 - - SYM cord-300311-eah49b3g 4 7 30 30 CD cord-300311-eah49b3g 4 8 journal journal NN cord-300311-eah49b3g 4 9 : : : cord-300311-eah49b3g 5 1 Curr Curr NNP cord-300311-eah49b3g 5 2 Allergy Allergy NNP cord-300311-eah49b3g 5 3 Asthma Asthma NNP cord-300311-eah49b3g 5 4 Rep Rep NNP cord-300311-eah49b3g 5 5 DOI DOI NNP cord-300311-eah49b3g 5 6 : : : cord-300311-eah49b3g 6 1 10.1007 10.1007 CD cord-300311-eah49b3g 6 2 / / SYM cord-300311-eah49b3g 6 3 s11882 s11882 NN cord-300311-eah49b3g 6 4 - - HYPH cord-300311-eah49b3g 6 5 007 007 CD cord-300311-eah49b3g 6 6 - - HYPH cord-300311-eah49b3g 6 7 0033-z 0033-z CD cord-300311-eah49b3g 7 1 sha sha NNP cord-300311-eah49b3g 7 2 : : : cord-300311-eah49b3g 8 1 522cd6b4bb68bdaaa1dca3bae13fed29c9a69884 522cd6b4bb68bdaaa1dca3bae13fed29c9a69884 CD cord-300311-eah49b3g 8 2 doc_id doc_id CD cord-300311-eah49b3g 8 3 : : : cord-300311-eah49b3g 8 4 300311 300311 CD cord-300311-eah49b3g 8 5 cord_uid cord_uid NNS cord-300311-eah49b3g 8 6 : : : cord-300311-eah49b3g 9 1 eah49b3 eah49b3 NNP cord-300311-eah49b3g 9 2 g g NNP cord-300311-eah49b3g 10 1 It -PRON- PRP cord-300311-eah49b3g 10 2 is be VBZ cord-300311-eah49b3g 10 3 estimated estimate VBN cord-300311-eah49b3g 10 4 that that IN cord-300311-eah49b3g 10 5 viruses virus NNS cord-300311-eah49b3g 10 6 play play VBP cord-300311-eah49b3g 10 7 a a DT cord-300311-eah49b3g 10 8 role role NN cord-300311-eah49b3g 10 9 in in IN cord-300311-eah49b3g 10 10 30 30 CD cord-300311-eah49b3g 10 11 % % NN cord-300311-eah49b3g 10 12 to to TO cord-300311-eah49b3g 10 13 80 80 CD cord-300311-eah49b3g 10 14 % % NN cord-300311-eah49b3g 10 15 of of IN cord-300311-eah49b3g 10 16 asthma asthma NN cord-300311-eah49b3g 10 17 exacerbations exacerbation NNS cord-300311-eah49b3g 10 18 . . . cord-300311-eah49b3g 11 1 Thus thus RB cord-300311-eah49b3g 11 2 , , , cord-300311-eah49b3g 11 3 virus virus NN cord-300311-eah49b3g 11 4 vaccination vaccination NN cord-300311-eah49b3g 11 5 in in IN cord-300311-eah49b3g 11 6 patients patient NNS cord-300311-eah49b3g 11 7 with with IN cord-300311-eah49b3g 11 8 asthma asthma NN cord-300311-eah49b3g 11 9 could could MD cord-300311-eah49b3g 11 10 play play VB cord-300311-eah49b3g 11 11 an an DT cord-300311-eah49b3g 11 12 important important JJ cord-300311-eah49b3g 11 13 role role NN cord-300311-eah49b3g 11 14 in in IN cord-300311-eah49b3g 11 15 preventing prevent VBG cord-300311-eah49b3g 11 16 asthma asthma NN cord-300311-eah49b3g 11 17 exacerbations exacerbation NNS cord-300311-eah49b3g 11 18 and and CC cord-300311-eah49b3g 11 19 other other JJ cord-300311-eah49b3g 11 20 complications complication NNS cord-300311-eah49b3g 11 21 . . . cord-300311-eah49b3g 12 1 Influenza influenza NN cord-300311-eah49b3g 12 2 is be VBZ cord-300311-eah49b3g 12 3 the the DT cord-300311-eah49b3g 12 4 only only JJ cord-300311-eah49b3g 12 5 agent agent NN cord-300311-eah49b3g 12 6 for for IN cord-300311-eah49b3g 12 7 which which WDT cord-300311-eah49b3g 12 8 a a DT cord-300311-eah49b3g 12 9 routine routine JJ cord-300311-eah49b3g 12 10 vaccine vaccine NN cord-300311-eah49b3g 12 11 is be VBZ cord-300311-eah49b3g 12 12 currently currently RB cord-300311-eah49b3g 12 13 available available JJ cord-300311-eah49b3g 12 14 . . . cord-300311-eah49b3g 13 1 This this DT cord-300311-eah49b3g 13 2 article article NN cord-300311-eah49b3g 13 3 discusses discuss VBZ cord-300311-eah49b3g 13 4 whether whether IN cord-300311-eah49b3g 13 5 influenza influenza NN cord-300311-eah49b3g 13 6 vaccination vaccination NN cord-300311-eah49b3g 13 7 in in IN cord-300311-eah49b3g 13 8 patients patient NNS cord-300311-eah49b3g 13 9 with with IN cord-300311-eah49b3g 13 10 asthma asthma NN cord-300311-eah49b3g 13 11 , , , cord-300311-eah49b3g 13 12 based base VBN cord-300311-eah49b3g 13 13 on on IN cord-300311-eah49b3g 13 14 the the DT cord-300311-eah49b3g 13 15 available available JJ cord-300311-eah49b3g 13 16 evidence evidence NN cord-300311-eah49b3g 13 17 , , , cord-300311-eah49b3g 13 18 is be VBZ cord-300311-eah49b3g 13 19 justified justify VBN cord-300311-eah49b3g 13 20 . . . cord-300311-eah49b3g 14 1 Cost cost NN cord-300311-eah49b3g 14 2 - - HYPH cord-300311-eah49b3g 14 3 effectiveness effectiveness NN cord-300311-eah49b3g 14 4 of of IN cord-300311-eah49b3g 14 5 ( ( -LRB- cord-300311-eah49b3g 14 6 influenza influenza NN cord-300311-eah49b3g 14 7 ) ) -RRB- cord-300311-eah49b3g 14 8 vaccination vaccination NN cord-300311-eah49b3g 14 9 for for IN cord-300311-eah49b3g 14 10 patients patient NNS cord-300311-eah49b3g 14 11 with with IN cord-300311-eah49b3g 14 12 asthma asthma NN cord-300311-eah49b3g 14 13 is be VBZ cord-300311-eah49b3g 14 14 questionable questionable JJ cord-300311-eah49b3g 14 15 . . . cord-300311-eah49b3g 15 1 For for IN cord-300311-eah49b3g 15 2 the the DT cord-300311-eah49b3g 15 3 other other JJ cord-300311-eah49b3g 15 4 major major JJ cord-300311-eah49b3g 15 5 viruses virus NNS cord-300311-eah49b3g 15 6 involved involve VBN cord-300311-eah49b3g 15 7 , , , cord-300311-eah49b3g 15 8 the the DT cord-300311-eah49b3g 15 9 present present JJ cord-300311-eah49b3g 15 10 state state NN cord-300311-eah49b3g 15 11 of of IN cord-300311-eah49b3g 15 12 affairs affair NNS cord-300311-eah49b3g 15 13 is be VBZ cord-300311-eah49b3g 15 14 described describe VBN cord-300311-eah49b3g 15 15 . . . cord-300311-eah49b3g 16 1 Although although IN cord-300311-eah49b3g 16 2 progress progress NN cord-300311-eah49b3g 16 3 is be VBZ cord-300311-eah49b3g 16 4 being be VBG cord-300311-eah49b3g 16 5 made make VBN cord-300311-eah49b3g 16 6 , , , cord-300311-eah49b3g 16 7 a a DT cord-300311-eah49b3g 16 8 vaccine vaccine NN cord-300311-eah49b3g 16 9 may may MD cord-300311-eah49b3g 16 10 be be VB cord-300311-eah49b3g 16 11 available available JJ cord-300311-eah49b3g 16 12 in in IN cord-300311-eah49b3g 16 13 the the DT cord-300311-eah49b3g 16 14 near near JJ cord-300311-eah49b3g 16 15 future future NN cord-300311-eah49b3g 16 16 only only RB cord-300311-eah49b3g 16 17 for for IN cord-300311-eah49b3g 16 18 respiratory respiratory JJ cord-300311-eah49b3g 16 19 syncytial syncytial JJ cord-300311-eah49b3g 16 20 virus virus NN cord-300311-eah49b3g 16 21 ( ( -LRB- cord-300311-eah49b3g 16 22 RSV RSV NNP cord-300311-eah49b3g 16 23 ) ) -RRB- cord-300311-eah49b3g 16 24 . . . cord-300311-eah49b3g 17 1 Meanwhile meanwhile RB cord-300311-eah49b3g 17 2 , , , cord-300311-eah49b3g 17 3 clinicians clinician NNS cord-300311-eah49b3g 17 4 and and CC cord-300311-eah49b3g 17 5 patients patient NNS cord-300311-eah49b3g 17 6 should should MD cord-300311-eah49b3g 17 7 aim aim VB cord-300311-eah49b3g 17 8 for for IN cord-300311-eah49b3g 17 9 an an DT cord-300311-eah49b3g 17 10 optimal optimal JJ cord-300311-eah49b3g 17 11 treatment treatment NN cord-300311-eah49b3g 17 12 with with IN cord-300311-eah49b3g 17 13 the the DT cord-300311-eah49b3g 17 14 currently currently RB cord-300311-eah49b3g 17 15 available available JJ cord-300311-eah49b3g 17 16 asthma asthma NN cord-300311-eah49b3g 17 17 medication medication NN cord-300311-eah49b3g 17 18 . . . cord-300311-eah49b3g 18 1 Worldwide worldwide RB cord-300311-eah49b3g 18 2 , , , cord-300311-eah49b3g 18 3 asthma asthma NN cord-300311-eah49b3g 18 4 is be VBZ cord-300311-eah49b3g 18 5 one one CD cord-300311-eah49b3g 18 6 of of IN cord-300311-eah49b3g 18 7 the the DT cord-300311-eah49b3g 18 8 major major JJ cord-300311-eah49b3g 18 9 chronic chronic JJ cord-300311-eah49b3g 18 10 diseases disease NNS cord-300311-eah49b3g 18 11 and and CC cord-300311-eah49b3g 18 12 there there EX cord-300311-eah49b3g 18 13 is be VBZ cord-300311-eah49b3g 18 14 evidence evidence NN cord-300311-eah49b3g 18 15 its -PRON- PRP$ cord-300311-eah49b3g 18 16 incidence incidence NN cord-300311-eah49b3g 18 17 and and CC cord-300311-eah49b3g 18 18 prevalence prevalence NN cord-300311-eah49b3g 18 19 is be VBZ cord-300311-eah49b3g 18 20 still still RB cord-300311-eah49b3g 18 21 growing grow VBG cord-300311-eah49b3g 18 22 [ [ -LRB- cord-300311-eah49b3g 18 23 1 1 CD cord-300311-eah49b3g 18 24 ] ] -RRB- cord-300311-eah49b3g 18 25 . . . cord-300311-eah49b3g 19 1 Today today NN cord-300311-eah49b3g 19 2 asthma asthma NN cord-300311-eah49b3g 19 3 is be VBZ cord-300311-eah49b3g 19 4 regarded regard VBN cord-300311-eah49b3g 19 5 as as IN cord-300311-eah49b3g 19 6 a a DT cord-300311-eah49b3g 19 7 chronic chronic JJ cord-300311-eah49b3g 19 8 inflammatory inflammatory JJ cord-300311-eah49b3g 19 9 disease disease NN cord-300311-eah49b3g 19 10 of of IN cord-300311-eah49b3g 19 11 the the DT cord-300311-eah49b3g 19 12 airways airways NNPS cord-300311-eah49b3g 19 13 instead instead RB cord-300311-eah49b3g 19 14 of of IN cord-300311-eah49b3g 19 15 solely solely RB cord-300311-eah49b3g 19 16 a a DT cord-300311-eah49b3g 19 17 reversible reversible JJ cord-300311-eah49b3g 19 18 airway airway NN cord-300311-eah49b3g 19 19 obstruction obstruction NN cord-300311-eah49b3g 19 20 . . . cord-300311-eah49b3g 20 1 The the DT cord-300311-eah49b3g 20 2 use use NN cord-300311-eah49b3g 20 3 of of IN cord-300311-eah49b3g 20 4 rescue rescue NN cord-300311-eah49b3g 20 5 and and CC cord-300311-eah49b3g 20 6 anti anti JJ cord-300311-eah49b3g 20 7 - - JJ cord-300311-eah49b3g 20 8 inflammatory inflammatory JJ cord-300311-eah49b3g 20 9 medication medication NN cord-300311-eah49b3g 20 10 has have VBZ cord-300311-eah49b3g 20 11 altered alter VBN cord-300311-eah49b3g 20 12 the the DT cord-300311-eah49b3g 20 13 prospects prospect NNS cord-300311-eah49b3g 20 14 of of IN cord-300311-eah49b3g 20 15 asthma asthma NN cord-300311-eah49b3g 20 16 patients patient NNS cord-300311-eah49b3g 20 17 and and CC cord-300311-eah49b3g 20 18 has have VBZ cord-300311-eah49b3g 20 19 improved improve VBN cord-300311-eah49b3g 20 20 their -PRON- PRP$ cord-300311-eah49b3g 20 21 quality quality NN cord-300311-eah49b3g 20 22 of of IN cord-300311-eah49b3g 20 23 life life NN cord-300311-eah49b3g 20 24 . . . cord-300311-eah49b3g 21 1 Thus thus RB cord-300311-eah49b3g 21 2 , , , cord-300311-eah49b3g 21 3 most most JJS cord-300311-eah49b3g 21 4 asthma asthma NN cord-300311-eah49b3g 21 5 patients patient NNS cord-300311-eah49b3g 21 6 can can MD cord-300311-eah49b3g 21 7 lead lead VB cord-300311-eah49b3g 21 8 a a DT cord-300311-eah49b3g 21 9 normal normal JJ cord-300311-eah49b3g 21 10 life life NN cord-300311-eah49b3g 21 11 without without IN cord-300311-eah49b3g 21 12 restrictions restriction NNS cord-300311-eah49b3g 21 13 . . . cord-300311-eah49b3g 22 1 The the DT cord-300311-eah49b3g 22 2 degree degree NN cord-300311-eah49b3g 22 3 of of IN cord-300311-eah49b3g 22 4 asthma asthma NN cord-300311-eah49b3g 22 5 control control NN cord-300311-eah49b3g 22 6 achieved achieve VBN cord-300311-eah49b3g 22 7 by by IN cord-300311-eah49b3g 22 8 patients patient NNS cord-300311-eah49b3g 22 9 is be VBZ cord-300311-eah49b3g 22 10 an an DT cord-300311-eah49b3g 22 11 important important JJ cord-300311-eah49b3g 22 12 predictor predictor NN cord-300311-eah49b3g 22 13 of of IN cord-300311-eah49b3g 22 14 the the DT cord-300311-eah49b3g 22 15 likelihood likelihood NN cord-300311-eah49b3g 22 16 of of IN cord-300311-eah49b3g 22 17 complications complication NNS cord-300311-eah49b3g 22 18 of of IN cord-300311-eah49b3g 22 19 the the DT cord-300311-eah49b3g 22 20 disease disease NN cord-300311-eah49b3g 22 21 [ [ -LRB- cord-300311-eah49b3g 22 22 2• 2• CD cord-300311-eah49b3g 22 23 ] ] -RRB- cord-300311-eah49b3g 22 24 . . . cord-300311-eah49b3g 23 1 However however RB cord-300311-eah49b3g 23 2 , , , cord-300311-eah49b3g 23 3 upper upper JJ cord-300311-eah49b3g 23 4 and and CC cord-300311-eah49b3g 23 5 lower low JJR cord-300311-eah49b3g 23 6 respiratory respiratory JJ cord-300311-eah49b3g 23 7 infections infection NNS cord-300311-eah49b3g 23 8 can can MD cord-300311-eah49b3g 23 9 trigger trigger VB cord-300311-eah49b3g 23 10 exacerbations exacerbation NNS cord-300311-eah49b3g 23 11 of of IN cord-300311-eah49b3g 23 12 acute acute JJ cord-300311-eah49b3g 23 13 asthma asthma NN cord-300311-eah49b3g 23 14 . . . cord-300311-eah49b3g 24 1 Most Most JJS cord-300311-eah49b3g 24 2 infections infection NNS cord-300311-eah49b3g 24 3 have have VBP cord-300311-eah49b3g 24 4 a a DT cord-300311-eah49b3g 24 5 viral viral JJ cord-300311-eah49b3g 24 6 origin origin NN cord-300311-eah49b3g 24 7 . . . cord-300311-eah49b3g 25 1 They -PRON- PRP cord-300311-eah49b3g 25 2 play play VBP cord-300311-eah49b3g 25 3 an an DT cord-300311-eah49b3g 25 4 important important JJ cord-300311-eah49b3g 25 5 role role NN cord-300311-eah49b3g 25 6 in in IN cord-300311-eah49b3g 25 7 clinical clinical JJ cord-300311-eah49b3g 25 8 complications complication NNS cord-300311-eah49b3g 25 9 of of IN cord-300311-eah49b3g 25 10 asthma asthma NN cord-300311-eah49b3g 25 11 such such JJ cord-300311-eah49b3g 25 12 as as IN cord-300311-eah49b3g 25 13 dyspnea dyspnea NN cord-300311-eah49b3g 25 14 , , , cord-300311-eah49b3g 25 15 pneumonia pneumonia NN cord-300311-eah49b3g 25 16 , , , cord-300311-eah49b3g 25 17 and and CC cord-300311-eah49b3g 25 18 respiratory respiratory JJ cord-300311-eah49b3g 25 19 insufficiency insufficiency NN cord-300311-eah49b3g 25 20 , , , cord-300311-eah49b3g 25 21 which which WDT cord-300311-eah49b3g 25 22 result result VBP cord-300311-eah49b3g 25 23 in in IN cord-300311-eah49b3g 25 24 loss loss NN cord-300311-eah49b3g 25 25 of of IN cord-300311-eah49b3g 25 26 quality quality NN cord-300311-eah49b3g 25 27 of of IN cord-300311-eah49b3g 25 28 life life NN cord-300311-eah49b3g 25 29 , , , cord-300311-eah49b3g 25 30 absenteeism absenteeism NN cord-300311-eah49b3g 25 31 , , , cord-300311-eah49b3g 25 32 use use NN cord-300311-eah49b3g 25 33 of of IN cord-300311-eah49b3g 25 34 rescue rescue NN cord-300311-eah49b3g 25 35 medication medication NN cord-300311-eah49b3g 25 36 , , , cord-300311-eah49b3g 25 37 use use NN cord-300311-eah49b3g 25 38 of of IN cord-300311-eah49b3g 25 39 antibiotics antibiotic NNS cord-300311-eah49b3g 25 40 , , , cord-300311-eah49b3g 25 41 physician physician NN cord-300311-eah49b3g 25 42 consultation consultation NN cord-300311-eah49b3g 25 43 , , , cord-300311-eah49b3g 25 44 emergency emergency NN cord-300311-eah49b3g 25 45 department department NN cord-300311-eah49b3g 25 46 visits visit VBZ cord-300311-eah49b3g 25 47 , , , cord-300311-eah49b3g 25 48 hospitalization hospitalization NN cord-300311-eah49b3g 25 49 , , , cord-300311-eah49b3g 25 50 and and CC cord-300311-eah49b3g 25 51 sometimes sometimes RB cord-300311-eah49b3g 25 52 death death NN cord-300311-eah49b3g 25 53 . . . cord-300311-eah49b3g 26 1 The the DT cord-300311-eah49b3g 26 2 best good JJS cord-300311-eah49b3g 26 3 way way NN cord-300311-eah49b3g 26 4 to to TO cord-300311-eah49b3g 26 5 prevent prevent VB cord-300311-eah49b3g 26 6 exacerbations exacerbation NNS cord-300311-eah49b3g 26 7 caused cause VBN cord-300311-eah49b3g 26 8 by by IN cord-300311-eah49b3g 26 9 infection infection NN cord-300311-eah49b3g 26 10 is be VBZ cord-300311-eah49b3g 26 11 vaccination vaccination NN cord-300311-eah49b3g 26 12 . . . cord-300311-eah49b3g 27 1 This this DT cord-300311-eah49b3g 27 2 review review NN cord-300311-eah49b3g 27 3 summarizes summarize VBZ cord-300311-eah49b3g 27 4 the the DT cord-300311-eah49b3g 27 5 current current JJ cord-300311-eah49b3g 27 6 evidence evidence NN cord-300311-eah49b3g 27 7 on on IN cord-300311-eah49b3g 27 8 the the DT cord-300311-eah49b3g 27 9 role role NN cord-300311-eah49b3g 27 10 of of IN cord-300311-eah49b3g 27 11 viral viral JJ cord-300311-eah49b3g 27 12 vaccination vaccination NN cord-300311-eah49b3g 27 13 in in IN cord-300311-eah49b3g 27 14 the the DT cord-300311-eah49b3g 27 15 protection protection NN cord-300311-eah49b3g 27 16 of of IN cord-300311-eah49b3g 27 17 asthma asthma NN cord-300311-eah49b3g 27 18 patients patient NNS cord-300311-eah49b3g 27 19 . . . cord-300311-eah49b3g 28 1 We -PRON- PRP cord-300311-eah49b3g 28 2 searched search VBD cord-300311-eah49b3g 28 3 Medline Medline NNP cord-300311-eah49b3g 28 4 and and CC cord-300311-eah49b3g 28 5 Google Google NNP cord-300311-eah49b3g 28 6 Scholar Scholar NNP cord-300311-eah49b3g 28 7 for for IN cord-300311-eah49b3g 28 8 relevant relevant JJ cord-300311-eah49b3g 28 9 articles article NNS cord-300311-eah49b3g 28 10 and and CC cord-300311-eah49b3g 28 11 reports report NNS cord-300311-eah49b3g 28 12 published publish VBN cord-300311-eah49b3g 28 13 between between IN cord-300311-eah49b3g 28 14 1999 1999 CD cord-300311-eah49b3g 28 15 and and CC cord-300311-eah49b3g 28 16 July July NNP cord-300311-eah49b3g 28 17 2006 2006 CD cord-300311-eah49b3g 28 18 on on IN cord-300311-eah49b3g 28 19 the the DT cord-300311-eah49b3g 28 20 current current JJ cord-300311-eah49b3g 28 21 status status NN cord-300311-eah49b3g 28 22 of of IN cord-300311-eah49b3g 28 23 vaccination vaccination NN cord-300311-eah49b3g 28 24 in in IN cord-300311-eah49b3g 28 25 patients patient NNS cord-300311-eah49b3g 28 26 with with IN cord-300311-eah49b3g 28 27 asthma asthma NN cord-300311-eah49b3g 28 28 . . . cord-300311-eah49b3g 29 1 Viral viral JJ cord-300311-eah49b3g 29 2 infections infection NNS cord-300311-eah49b3g 29 3 have have VBP cord-300311-eah49b3g 29 4 long long RB cord-300311-eah49b3g 29 5 been be VBN cord-300311-eah49b3g 29 6 associated associate VBN cord-300311-eah49b3g 29 7 with with IN cord-300311-eah49b3g 29 8 asthma asthma NN cord-300311-eah49b3g 29 9 exacerbations exacerbation NNS cord-300311-eah49b3g 29 10 . . . cord-300311-eah49b3g 30 1 Studies study NNS cord-300311-eah49b3g 30 2 in in IN cord-300311-eah49b3g 30 3 children child NNS cord-300311-eah49b3g 30 4 report report VBP cord-300311-eah49b3g 30 5 varying vary VBG cord-300311-eah49b3g 30 6 incidences incidence NNS cord-300311-eah49b3g 30 7 , , , cord-300311-eah49b3g 30 8 suggesting suggest VBG cord-300311-eah49b3g 30 9 that that IN cord-300311-eah49b3g 30 10 between between IN cord-300311-eah49b3g 30 11 30 30 CD cord-300311-eah49b3g 30 12 % % NN cord-300311-eah49b3g 30 13 and and CC cord-300311-eah49b3g 30 14 80 80 CD cord-300311-eah49b3g 30 15 % % NN cord-300311-eah49b3g 30 16 of of IN cord-300311-eah49b3g 30 17 exacerbations exacerbation NNS cord-300311-eah49b3g 30 18 are be VBP cord-300311-eah49b3g 30 19 due due JJ cord-300311-eah49b3g 30 20 to to IN cord-300311-eah49b3g 30 21 a a DT cord-300311-eah49b3g 30 22 virus virus NN cord-300311-eah49b3g 30 23 [ [ -LRB- cord-300311-eah49b3g 30 24 3 3 CD cord-300311-eah49b3g 30 25 ] ] -RRB- cord-300311-eah49b3g 30 26 [ [ -LRB- cord-300311-eah49b3g 30 27 4 4 CD cord-300311-eah49b3g 30 28 ] ] -RRB- cord-300311-eah49b3g 30 29 [ [ -LRB- cord-300311-eah49b3g 30 30 5 5 CD cord-300311-eah49b3g 30 31 ] ] -RRB- cord-300311-eah49b3g 30 32 [ [ -LRB- cord-300311-eah49b3g 30 33 6 6 CD cord-300311-eah49b3g 30 34 ] ] -RRB- cord-300311-eah49b3g 30 35 . . . cord-300311-eah49b3g 31 1 For for IN cord-300311-eah49b3g 31 2 adults adult NNS cord-300311-eah49b3g 31 3 data datum NNS cord-300311-eah49b3g 31 4 on on IN cord-300311-eah49b3g 31 5 this this DT cord-300311-eah49b3g 31 6 issue issue NN cord-300311-eah49b3g 31 7 are be VBP cord-300311-eah49b3g 31 8 scarcer scarce JJR cord-300311-eah49b3g 31 9 , , , cord-300311-eah49b3g 31 10 but but CC cord-300311-eah49b3g 31 11 adults adult NNS cord-300311-eah49b3g 31 12 are be VBP cord-300311-eah49b3g 31 13 believed believe VBN cord-300311-eah49b3g 31 14 to to TO cord-300311-eah49b3g 31 15 have have VB cord-300311-eah49b3g 31 16 as as RB cord-300311-eah49b3g 31 17 many many JJ cord-300311-eah49b3g 31 18 asthma asthma NN cord-300311-eah49b3g 31 19 exacerbations exacerbation NNS cord-300311-eah49b3g 31 20 linked link VBN cord-300311-eah49b3g 31 21 with with IN cord-300311-eah49b3g 31 22 viral viral JJ cord-300311-eah49b3g 31 23 infections infection NNS cord-300311-eah49b3g 31 24 as as IN cord-300311-eah49b3g 31 25 children child NNS cord-300311-eah49b3g 31 26 [ [ -LRB- cord-300311-eah49b3g 31 27 7 7 CD cord-300311-eah49b3g 31 28 , , , cord-300311-eah49b3g 31 29 8 8 CD cord-300311-eah49b3g 31 30 ] ] -RRB- cord-300311-eah49b3g 31 31 . . . cord-300311-eah49b3g 32 1 The the DT cord-300311-eah49b3g 32 2 spectrum spectrum NN cord-300311-eah49b3g 32 3 of of IN cord-300311-eah49b3g 32 4 viruses virus NNS cord-300311-eah49b3g 32 5 found find VBN cord-300311-eah49b3g 32 6 consists consist NNS cord-300311-eah49b3g 32 7 of of IN cord-300311-eah49b3g 32 8 rhinovirus rhinovirus NN cord-300311-eah49b3g 32 9 , , , cord-300311-eah49b3g 32 10 coronavirus coronavirus NN cord-300311-eah49b3g 32 11 , , , cord-300311-eah49b3g 32 12 respiratory respiratory JJ cord-300311-eah49b3g 32 13 syncytial syncytial JJ cord-300311-eah49b3g 32 14 virus virus NN cord-300311-eah49b3g 32 15 ( ( -LRB- cord-300311-eah49b3g 32 16 RSV RSV NNP cord-300311-eah49b3g 32 17 ) ) -RRB- cord-300311-eah49b3g 32 18 , , , cord-300311-eah49b3g 32 19 influenza influenza NN cord-300311-eah49b3g 32 20 virus virus NN cord-300311-eah49b3g 32 21 , , , cord-300311-eah49b3g 32 22 and and CC cord-300311-eah49b3g 32 23 an an DT cord-300311-eah49b3g 32 24 assortment assortment NN cord-300311-eah49b3g 32 25 of of IN cord-300311-eah49b3g 32 26 other other JJ cord-300311-eah49b3g 32 27 viruses virus NNS cord-300311-eah49b3g 32 28 . . . cord-300311-eah49b3g 33 1 Of of IN cord-300311-eah49b3g 33 2 these these DT cord-300311-eah49b3g 33 3 , , , cord-300311-eah49b3g 33 4 RSV RSV NNP cord-300311-eah49b3g 33 5 and and CC cord-300311-eah49b3g 33 6 influenza influenza NN cord-300311-eah49b3g 33 7 affect affect VBP cord-300311-eah49b3g 33 8 primarily primarily RB cord-300311-eah49b3g 33 9 the the DT cord-300311-eah49b3g 33 10 lower low JJR cord-300311-eah49b3g 33 11 respiratory respiratory JJ cord-300311-eah49b3g 33 12 tract tract NN cord-300311-eah49b3g 33 13 , , , cord-300311-eah49b3g 33 14 whereas whereas IN cord-300311-eah49b3g 33 15 rhinovirus rhinovirus NN cord-300311-eah49b3g 33 16 and and CC cord-300311-eah49b3g 33 17 coronavirus coronavirus NN cord-300311-eah49b3g 33 18 replicate replicate VBP cord-300311-eah49b3g 33 19 in in IN cord-300311-eah49b3g 33 20 the the DT cord-300311-eah49b3g 33 21 upper upper JJ cord-300311-eah49b3g 33 22 respiratory respiratory JJ cord-300311-eah49b3g 33 23 tract tract NN cord-300311-eah49b3g 33 24 . . . cord-300311-eah49b3g 34 1 The the DT cord-300311-eah49b3g 34 2 mechanism mechanism NN cord-300311-eah49b3g 34 3 by by IN cord-300311-eah49b3g 34 4 which which WDT cord-300311-eah49b3g 34 5 these these DT cord-300311-eah49b3g 34 6 viruses virus NNS cord-300311-eah49b3g 34 7 cause cause VBP cord-300311-eah49b3g 34 8 asthma asthma NN cord-300311-eah49b3g 34 9 exacerbations exacerbation NNS cord-300311-eah49b3g 34 10 is be VBZ cord-300311-eah49b3g 34 11 not not RB cord-300311-eah49b3g 34 12 yet yet RB cord-300311-eah49b3g 34 13 known know VBN cord-300311-eah49b3g 34 14 precisely precisely RB cord-300311-eah49b3g 34 15 . . . cord-300311-eah49b3g 35 1 Postulations postulation NNS cord-300311-eah49b3g 35 2 vary vary VBP cord-300311-eah49b3g 35 3 from from IN cord-300311-eah49b3g 35 4 direct direct JJ cord-300311-eah49b3g 35 5 infection infection NN cord-300311-eah49b3g 35 6 to to IN cord-300311-eah49b3g 35 7 indirect indirect JJ cord-300311-eah49b3g 35 8 induction induction NN cord-300311-eah49b3g 35 9 of of IN cord-300311-eah49b3g 35 10 inflammatory inflammatory JJ cord-300311-eah49b3g 35 11 responses response NNS cord-300311-eah49b3g 35 12 [ [ -LRB- cord-300311-eah49b3g 35 13 9 9 CD cord-300311-eah49b3g 35 14 ] ] -RRB- cord-300311-eah49b3g 35 15 . . . cord-300311-eah49b3g 36 1 In in IN cord-300311-eah49b3g 36 2 case case NN cord-300311-eah49b3g 36 3 of of IN cord-300311-eah49b3g 36 4 complications complication NNS cord-300311-eah49b3g 36 5 in in IN cord-300311-eah49b3g 36 6 patients patient NNS cord-300311-eah49b3g 36 7 with with IN cord-300311-eah49b3g 36 8 asthma asthma NN cord-300311-eah49b3g 36 9 , , , cord-300311-eah49b3g 36 10 laboratory laboratory NN cord-300311-eah49b3g 36 11 proof proof NN cord-300311-eah49b3g 36 12 for for IN cord-300311-eah49b3g 36 13 the the DT cord-300311-eah49b3g 36 14 presence presence NN cord-300311-eah49b3g 36 15 of of IN cord-300311-eah49b3g 36 16 virus virus NN cord-300311-eah49b3g 36 17 should should MD cord-300311-eah49b3g 36 18 preferably preferably RB cord-300311-eah49b3g 36 19 coincide coincide VB cord-300311-eah49b3g 36 20 with with IN cord-300311-eah49b3g 36 21 symptomatic symptomatic JJ cord-300311-eah49b3g 36 22 disease disease NN cord-300311-eah49b3g 36 23 . . . cord-300311-eah49b3g 37 1 However however RB cord-300311-eah49b3g 37 2 , , , cord-300311-eah49b3g 37 3 evidence evidence NN cord-300311-eah49b3g 37 4 for for IN cord-300311-eah49b3g 37 5 the the DT cord-300311-eah49b3g 37 6 rate rate NN cord-300311-eah49b3g 37 7 of of IN cord-300311-eah49b3g 37 8 complications complication NNS cord-300311-eah49b3g 37 9 mostly mostly RB cord-300311-eah49b3g 37 10 comes come VBZ cord-300311-eah49b3g 37 11 from from IN cord-300311-eah49b3g 37 12 large large JJ cord-300311-eah49b3g 37 13 observational observational JJ cord-300311-eah49b3g 37 14 studies study NNS cord-300311-eah49b3g 37 15 . . . cord-300311-eah49b3g 38 1 In in IN cord-300311-eah49b3g 38 2 these these DT cord-300311-eah49b3g 38 3 reports report NNS cord-300311-eah49b3g 38 4 on on IN cord-300311-eah49b3g 38 5 the the DT cord-300311-eah49b3g 38 6 impact impact NN cord-300311-eah49b3g 38 7 of of IN cord-300311-eah49b3g 38 8 viruses virus NNS cord-300311-eah49b3g 38 9 , , , cord-300311-eah49b3g 38 10 laboratory laboratory NN cord-300311-eah49b3g 38 11 proof proof NN cord-300311-eah49b3g 38 12 is be VBZ cord-300311-eah49b3g 38 13 often often RB cord-300311-eah49b3g 38 14 lacking lack VBG cord-300311-eah49b3g 38 15 . . . cord-300311-eah49b3g 39 1 Instead instead RB cord-300311-eah49b3g 39 2 , , , cord-300311-eah49b3g 39 3 extrapolated extrapolate VBN cord-300311-eah49b3g 39 4 , , , cord-300311-eah49b3g 39 5 partly partly RB cord-300311-eah49b3g 39 6 population population NN cord-300311-eah49b3g 39 7 - - HYPH cord-300311-eah49b3g 39 8 based base VBN cord-300311-eah49b3g 39 9 , , , cord-300311-eah49b3g 39 10 incidence incidence NN cord-300311-eah49b3g 39 11 rates rate NNS cord-300311-eah49b3g 39 12 of of IN cord-300311-eah49b3g 39 13 influenza influenza NN cord-300311-eah49b3g 39 14 or or CC cord-300311-eah49b3g 39 15 influenza influenza NN cord-300311-eah49b3g 39 16 - - HYPH cord-300311-eah49b3g 39 17 like like JJ cord-300311-eah49b3g 39 18 illness illness NN cord-300311-eah49b3g 39 19 and and CC cord-300311-eah49b3g 39 20 the the DT cord-300311-eah49b3g 39 21 occurrence occurrence NN cord-300311-eah49b3g 39 22 of of IN cord-300311-eah49b3g 39 23 complications complication NNS cord-300311-eah49b3g 39 24 are be VBP cord-300311-eah49b3g 39 25 used use VBN cord-300311-eah49b3g 39 26 as as IN cord-300311-eah49b3g 39 27 a a DT cord-300311-eah49b3g 39 28 proxy proxy NN cord-300311-eah49b3g 39 29 . . . cord-300311-eah49b3g 40 1 In in IN cord-300311-eah49b3g 40 2 these these DT cord-300311-eah49b3g 40 3 studies study NNS cord-300311-eah49b3g 40 4 , , , cord-300311-eah49b3g 40 5 hard hard JJ cord-300311-eah49b3g 40 6 confirmation confirmation NN cord-300311-eah49b3g 40 7 of of IN cord-300311-eah49b3g 40 8 the the DT cord-300311-eah49b3g 40 9 responsible responsible JJ cord-300311-eah49b3g 40 10 agent agent NN cord-300311-eah49b3g 40 11 on on IN cord-300311-eah49b3g 40 12 the the DT cord-300311-eah49b3g 40 13 individual individual JJ cord-300311-eah49b3g 40 14 level level NN cord-300311-eah49b3g 40 15 is be VBZ cord-300311-eah49b3g 40 16 not not RB cord-300311-eah49b3g 40 17 possible possible JJ cord-300311-eah49b3g 40 18 [ [ -LRB- cord-300311-eah49b3g 40 19 10 10 CD cord-300311-eah49b3g 40 20 ] ] -RRB- cord-300311-eah49b3g 40 21 [ [ -LRB- cord-300311-eah49b3g 40 22 11 11 CD cord-300311-eah49b3g 40 23 ] ] -RRB- cord-300311-eah49b3g 40 24 [ [ -LRB- cord-300311-eah49b3g 40 25 12 12 CD cord-300311-eah49b3g 40 26 ] ] -RRB- cord-300311-eah49b3g 40 27 [ [ -LRB- cord-300311-eah49b3g 40 28 13 13 CD cord-300311-eah49b3g 40 29 ] ] -RRB- cord-300311-eah49b3g 40 30 . . . cord-300311-eah49b3g 41 1 Other other JJ cord-300311-eah49b3g 41 2 studies study NNS cord-300311-eah49b3g 41 3 are be VBP cord-300311-eah49b3g 41 4 often often RB cord-300311-eah49b3g 41 5 based base VBN cord-300311-eah49b3g 41 6 on on IN cord-300311-eah49b3g 41 7 selected select VBN cord-300311-eah49b3g 41 8 populations population NNS cord-300311-eah49b3g 41 9 with with IN cord-300311-eah49b3g 41 10 existing exist VBG cord-300311-eah49b3g 41 11 symptoms symptom NNS cord-300311-eah49b3g 41 12 or or CC cord-300311-eah49b3g 41 13 complications complication NNS cord-300311-eah49b3g 41 14 , , , cord-300311-eah49b3g 41 15 reflecting reflect VBG cord-300311-eah49b3g 41 16 only only RB cord-300311-eah49b3g 41 17 the the DT cord-300311-eah49b3g 41 18 worst bad JJS cord-300311-eah49b3g 41 19 of of IN cord-300311-eah49b3g 41 20 the the DT cord-300311-eah49b3g 41 21 spectrum spectrum NN cord-300311-eah49b3g 41 22 of of IN cord-300311-eah49b3g 41 23 disease disease NN cord-300311-eah49b3g 41 24 caused cause VBN cord-300311-eah49b3g 41 25 by by IN cord-300311-eah49b3g 41 26 acute acute JJ cord-300311-eah49b3g 41 27 respiratory respiratory JJ cord-300311-eah49b3g 41 28 infections infection NNS cord-300311-eah49b3g 41 29 [ [ -LRB- cord-300311-eah49b3g 41 30 9 9 CD cord-300311-eah49b3g 41 31 , , , cord-300311-eah49b3g 41 32 [ [ -LRB- cord-300311-eah49b3g 41 33 14 14 CD cord-300311-eah49b3g 41 34 ] ] -RRB- cord-300311-eah49b3g 41 35 [ [ -LRB- cord-300311-eah49b3g 41 36 15 15 CD cord-300311-eah49b3g 41 37 ] ] -RRB- cord-300311-eah49b3g 41 38 [ [ -LRB- cord-300311-eah49b3g 41 39 16 16 CD cord-300311-eah49b3g 41 40 ] ] -RRB- cord-300311-eah49b3g 41 41 [ [ -LRB- cord-300311-eah49b3g 41 42 17 17 CD cord-300311-eah49b3g 41 43 ] ] -RRB- cord-300311-eah49b3g 41 44 ] ] -RRB- cord-300311-eah49b3g 41 45 and and CC cord-300311-eah49b3g 41 46 thus thus RB cord-300311-eah49b3g 41 47 disregarding disregard VBG cord-300311-eah49b3g 41 48 their -PRON- PRP$ cord-300311-eah49b3g 41 49 often often RB cord-300311-eah49b3g 41 50 self self NN cord-300311-eah49b3g 41 51 - - HYPH cord-300311-eah49b3g 41 52 limiting limit VBG cord-300311-eah49b3g 41 53 nature nature NN cord-300311-eah49b3g 41 54 . . . cord-300311-eah49b3g 42 1 Although although IN cord-300311-eah49b3g 42 2 asthma asthma NN cord-300311-eah49b3g 42 3 control control NN cord-300311-eah49b3g 42 4 achieved achieve VBN cord-300311-eah49b3g 42 5 by by IN cord-300311-eah49b3g 42 6 asthmatics asthmatic NNS cord-300311-eah49b3g 42 7 is be VBZ cord-300311-eah49b3g 42 8 an an DT cord-300311-eah49b3g 42 9 important important JJ cord-300311-eah49b3g 42 10 predictor predictor NN cord-300311-eah49b3g 42 11 of of IN cord-300311-eah49b3g 42 12 the the DT cord-300311-eah49b3g 42 13 likelihood likelihood NN cord-300311-eah49b3g 42 14 of of IN cord-300311-eah49b3g 42 15 complications complication NNS cord-300311-eah49b3g 42 16 of of IN cord-300311-eah49b3g 42 17 the the DT cord-300311-eah49b3g 42 18 disease disease NN cord-300311-eah49b3g 42 19 [ [ -LRB- cord-300311-eah49b3g 42 20 2• 2• CD cord-300311-eah49b3g 42 21 ] ] -RRB- cord-300311-eah49b3g 42 22 , , , cord-300311-eah49b3g 42 23 asthma asthma NN cord-300311-eah49b3g 42 24 exacerbations exacerbation NNS cord-300311-eah49b3g 42 25 do do VBP cord-300311-eah49b3g 42 26 not not RB cord-300311-eah49b3g 42 27 respond respond VB cord-300311-eah49b3g 42 28 to to IN cord-300311-eah49b3g 42 29 inhaled inhale VBN cord-300311-eah49b3g 42 30 steroids steroid NNS cord-300311-eah49b3g 42 31 nor nor CC cord-300311-eah49b3g 42 32 can can MD cord-300311-eah49b3g 42 33 they -PRON- PRP cord-300311-eah49b3g 42 34 substantially substantially RB cord-300311-eah49b3g 42 35 be be VB cord-300311-eah49b3g 42 36 prevented prevent VBN cord-300311-eah49b3g 42 37 in in IN cord-300311-eah49b3g 42 38 this this DT cord-300311-eah49b3g 42 39 way way NN cord-300311-eah49b3g 42 40 [ [ -LRB- cord-300311-eah49b3g 42 41 18 18 CD cord-300311-eah49b3g 42 42 , , , cord-300311-eah49b3g 42 43 19 19 CD cord-300311-eah49b3g 42 44 ] ] -RRB- cord-300311-eah49b3g 42 45 . . . cord-300311-eah49b3g 43 1 Only only RB cord-300311-eah49b3g 43 2 the the DT cord-300311-eah49b3g 43 3 use use NN cord-300311-eah49b3g 43 4 of of IN cord-300311-eah49b3g 43 5 oral oral JJ cord-300311-eah49b3g 43 6 corticosteroids corticosteroid NNS cord-300311-eah49b3g 43 7 seems seem VBZ cord-300311-eah49b3g 43 8 to to TO cord-300311-eah49b3g 43 9 be be VB cord-300311-eah49b3g 43 10 unmistakably unmistakably RB cord-300311-eah49b3g 43 11 effective effective JJ cord-300311-eah49b3g 43 12 [ [ -LRB- cord-300311-eah49b3g 43 13 20 20 CD cord-300311-eah49b3g 43 14 , , , cord-300311-eah49b3g 43 15 21 21 CD cord-300311-eah49b3g 43 16 ] ] -RRB- cord-300311-eah49b3g 43 17 . . . cord-300311-eah49b3g 44 1 The the DT cord-300311-eah49b3g 44 2 availability availability NN cord-300311-eah49b3g 44 3 of of IN cord-300311-eah49b3g 44 4 effective effective JJ cord-300311-eah49b3g 44 5 vaccines vaccine NNS cord-300311-eah49b3g 44 6 against against IN cord-300311-eah49b3g 44 7 the the DT cord-300311-eah49b3g 44 8 key key JJ cord-300311-eah49b3g 44 9 viruses virus NNS cord-300311-eah49b3g 44 10 involved involve VBN cord-300311-eah49b3g 44 11 in in IN cord-300311-eah49b3g 44 12 asthma asthma NN cord-300311-eah49b3g 44 13 exacerbations exacerbation NNS cord-300311-eah49b3g 44 14 thus thus RB cord-300311-eah49b3g 44 15 could could MD cord-300311-eah49b3g 44 16 play play VB cord-300311-eah49b3g 44 17 an an DT cord-300311-eah49b3g 44 18 important important JJ cord-300311-eah49b3g 44 19 role role NN cord-300311-eah49b3g 44 20 in in IN cord-300311-eah49b3g 44 21 its -PRON- PRP$ cord-300311-eah49b3g 44 22 prevention prevention NN cord-300311-eah49b3g 44 23 . . . cord-300311-eah49b3g 45 1 Below below RB cord-300311-eah49b3g 45 2 , , , cord-300311-eah49b3g 45 3 we -PRON- PRP cord-300311-eah49b3g 45 4 will will MD cord-300311-eah49b3g 45 5 discuss discuss VB cord-300311-eah49b3g 45 6 the the DT cord-300311-eah49b3g 45 7 vaccines vaccine NNS cord-300311-eah49b3g 45 8 that that WDT cord-300311-eah49b3g 45 9 are be VBP cord-300311-eah49b3g 45 10 available available JJ cord-300311-eah49b3g 45 11 or or CC cord-300311-eah49b3g 45 12 may may MD cord-300311-eah49b3g 45 13 become become VB cord-300311-eah49b3g 45 14 available available JJ cord-300311-eah49b3g 45 15 in in IN cord-300311-eah49b3g 45 16 the the DT cord-300311-eah49b3g 45 17 near near JJ cord-300311-eah49b3g 45 18 future future NN cord-300311-eah49b3g 45 19 [ [ -LRB- cord-300311-eah49b3g 45 20 22 22 CD cord-300311-eah49b3g 45 21 ] ] -RRB- cord-300311-eah49b3g 45 22 . . . cord-300311-eah49b3g 46 1 This this DT cord-300311-eah49b3g 46 2 species species NN cord-300311-eah49b3g 46 3 consists consist VBZ cord-300311-eah49b3g 46 4 of of IN cord-300311-eah49b3g 46 5 about about RB cord-300311-eah49b3g 46 6 100 100 CD cord-300311-eah49b3g 46 7 serotypes serotype NNS cord-300311-eah49b3g 46 8 and and CC cord-300311-eah49b3g 46 9 is be VBZ cord-300311-eah49b3g 46 10 responsible responsible JJ cord-300311-eah49b3g 46 11 for for IN cord-300311-eah49b3g 46 12 the the DT cord-300311-eah49b3g 46 13 majority majority NN cord-300311-eah49b3g 46 14 of of IN cord-300311-eah49b3g 46 15 " " `` cord-300311-eah49b3g 46 16 common common JJ cord-300311-eah49b3g 46 17 colds cold NNS cord-300311-eah49b3g 46 18 . . . cord-300311-eah49b3g 46 19 " " '' cord-300311-eah49b3g 47 1 In in IN cord-300311-eah49b3g 47 2 asthmatics asthmatic NNS cord-300311-eah49b3g 47 3 human human JJ cord-300311-eah49b3g 47 4 rhinoviruses rhinovirus NNS cord-300311-eah49b3g 47 5 are be VBP cord-300311-eah49b3g 47 6 responsible responsible JJ cord-300311-eah49b3g 47 7 for for IN cord-300311-eah49b3g 47 8 the the DT cord-300311-eah49b3g 47 9 majority majority NN cord-300311-eah49b3g 47 10 of of IN cord-300311-eah49b3g 47 11 asthma asthma NN cord-300311-eah49b3g 47 12 exacerbations exacerbation NNS cord-300311-eah49b3g 47 13 and and CC cord-300311-eah49b3g 47 14 complications complication NNS cord-300311-eah49b3g 47 15 of of IN cord-300311-eah49b3g 47 16 asthma asthma NN cord-300311-eah49b3g 47 17 [ [ -LRB- cord-300311-eah49b3g 47 18 23 23 CD cord-300311-eah49b3g 47 19 ] ] -RRB- cord-300311-eah49b3g 47 20 . . . cord-300311-eah49b3g 48 1 Prevalent prevalent JJ cord-300311-eah49b3g 48 2 serotypes serotype NNS cord-300311-eah49b3g 48 3 change change VBP cord-300311-eah49b3g 48 4 from from IN cord-300311-eah49b3g 48 5 year year NN cord-300311-eah49b3g 48 6 to to IN cord-300311-eah49b3g 48 7 year year NN cord-300311-eah49b3g 48 8 . . . cord-300311-eah49b3g 49 1 When when WRB cord-300311-eah49b3g 49 2 prevalent prevalent JJ cord-300311-eah49b3g 49 3 , , , cord-300311-eah49b3g 49 4 the the DT cord-300311-eah49b3g 49 5 relative relative JJ cord-300311-eah49b3g 49 6 predominance predominance NN cord-300311-eah49b3g 49 7 from from IN cord-300311-eah49b3g 49 8 any any DT cord-300311-eah49b3g 49 9 serotype serotype NN cord-300311-eah49b3g 49 10 is be VBZ cord-300311-eah49b3g 49 11 not not RB cord-300311-eah49b3g 49 12 higher high JJR cord-300311-eah49b3g 49 13 than than IN cord-300311-eah49b3g 49 14 40 40 CD cord-300311-eah49b3g 49 15 % % NN cord-300311-eah49b3g 49 16 . . . cord-300311-eah49b3g 50 1 Due due IN cord-300311-eah49b3g 50 2 to to IN cord-300311-eah49b3g 50 3 these these DT cord-300311-eah49b3g 50 4 circumstances circumstance NNS cord-300311-eah49b3g 50 5 and and CC cord-300311-eah49b3g 50 6 the the DT cord-300311-eah49b3g 50 7 large large JJ cord-300311-eah49b3g 50 8 number number NN cord-300311-eah49b3g 50 9 of of IN cord-300311-eah49b3g 50 10 serotypes serotype NNS cord-300311-eah49b3g 50 11 , , , cord-300311-eah49b3g 50 12 an an DT cord-300311-eah49b3g 50 13 effective effective JJ cord-300311-eah49b3g 50 14 vaccine vaccine NN cord-300311-eah49b3g 50 15 is be VBZ cord-300311-eah49b3g 50 16 not not RB cord-300311-eah49b3g 50 17 expected expect VBN cord-300311-eah49b3g 50 18 in in IN cord-300311-eah49b3g 50 19 the the DT cord-300311-eah49b3g 50 20 near near JJ cord-300311-eah49b3g 50 21 future future NN cord-300311-eah49b3g 50 22 [ [ -LRB- cord-300311-eah49b3g 50 23 22,24• 22,24• CD cord-300311-eah49b3g 50 24 ] ] -RRB- cord-300311-eah49b3g 50 25 . . . cord-300311-eah49b3g 51 1 Coronaviruses coronaviruse NNS cord-300311-eah49b3g 51 2 have have VBP cord-300311-eah49b3g 51 3 recently recently RB cord-300311-eah49b3g 51 4 been be VBN cord-300311-eah49b3g 51 5 highlighted highlight VBN cord-300311-eah49b3g 51 6 because because IN cord-300311-eah49b3g 51 7 of of IN cord-300311-eah49b3g 51 8 a a DT cord-300311-eah49b3g 51 9 disease disease NN cord-300311-eah49b3g 51 10 outbreak outbreak NN cord-300311-eah49b3g 51 11 caused cause VBN cord-300311-eah49b3g 51 12 by by IN cord-300311-eah49b3g 51 13 the the DT cord-300311-eah49b3g 51 14 so so RB cord-300311-eah49b3g 51 15 - - HYPH cord-300311-eah49b3g 51 16 called call VBN cord-300311-eah49b3g 51 17 severe severe JJ cord-300311-eah49b3g 51 18 acute acute JJ cord-300311-eah49b3g 51 19 respiratory respiratory JJ cord-300311-eah49b3g 51 20 syndrome syndrome NN cord-300311-eah49b3g 51 21 ( ( -LRB- cord-300311-eah49b3g 51 22 SARS SARS NNP cord-300311-eah49b3g 51 23 ) ) -RRB- cord-300311-eah49b3g 51 24 coronavirus coronavirus NN cord-300311-eah49b3g 51 25 . . . cord-300311-eah49b3g 52 1 In in IN cord-300311-eah49b3g 52 2 adults adult NNS cord-300311-eah49b3g 52 3 with with IN cord-300311-eah49b3g 52 4 asthma asthma NN cord-300311-eah49b3g 52 5 , , , cord-300311-eah49b3g 52 6 coronaviruses coronaviruse NNS cord-300311-eah49b3g 52 7 are be VBP cord-300311-eah49b3g 52 8 the the DT cord-300311-eah49b3g 52 9 second second JJ cord-300311-eah49b3g 52 10 most most RBS cord-300311-eah49b3g 52 11 important important JJ cord-300311-eah49b3g 52 12 cause cause NN cord-300311-eah49b3g 52 13 of of IN cord-300311-eah49b3g 52 14 virally virally RB cord-300311-eah49b3g 52 15 induced induce VBN cord-300311-eah49b3g 52 16 exacerbations exacerbation NNS cord-300311-eah49b3g 52 17 [ [ -LRB- cord-300311-eah49b3g 52 18 7 7 CD cord-300311-eah49b3g 52 19 , , , cord-300311-eah49b3g 52 20 8 8 CD cord-300311-eah49b3g 52 21 ] ] -RRB- cord-300311-eah49b3g 52 22 . . . cord-300311-eah49b3g 53 1 Animal animal NN cord-300311-eah49b3g 53 2 vaccines vaccine NNS cord-300311-eah49b3g 53 3 are be VBP cord-300311-eah49b3g 53 4 being be VBG cord-300311-eah49b3g 53 5 tested test VBN cord-300311-eah49b3g 53 6 . . . cord-300311-eah49b3g 54 1 Despite despite IN cord-300311-eah49b3g 54 2 this this DT cord-300311-eah49b3g 54 3 a a DT cord-300311-eah49b3g 54 4 vaccine vaccine NN cord-300311-eah49b3g 54 5 for for IN cord-300311-eah49b3g 54 6 human human JJ cord-300311-eah49b3g 54 7 use use NN cord-300311-eah49b3g 54 8 will will MD cord-300311-eah49b3g 54 9 probably probably RB cord-300311-eah49b3g 54 10 not not RB cord-300311-eah49b3g 54 11 be be VB cord-300311-eah49b3g 54 12 available available JJ cord-300311-eah49b3g 54 13 in in IN cord-300311-eah49b3g 54 14 the the DT cord-300311-eah49b3g 54 15 near near JJ cord-300311-eah49b3g 54 16 future future NN cord-300311-eah49b3g 54 17 [ [ -LRB- cord-300311-eah49b3g 54 18 22 22 CD cord-300311-eah49b3g 54 19 ] ] -RRB- cord-300311-eah49b3g 54 20 . . . cord-300311-eah49b3g 55 1 RSV RSV NNP cord-300311-eah49b3g 55 2 is be VBZ cord-300311-eah49b3g 55 3 especially especially RB cord-300311-eah49b3g 55 4 predominant predominant JJ cord-300311-eah49b3g 55 5 in in IN cord-300311-eah49b3g 55 6 young young JJ cord-300311-eah49b3g 55 7 childhood childhood NN cord-300311-eah49b3g 55 8 and and CC cord-300311-eah49b3g 55 9 causes cause NNS cord-300311-eah49b3g 55 10 wheezing wheeze VBG cord-300311-eah49b3g 55 11 in in IN cord-300311-eah49b3g 55 12 children child NNS cord-300311-eah49b3g 55 13 . . . cord-300311-eah49b3g 56 1 In in IN cord-300311-eah49b3g 56 2 elderly elderly JJ cord-300311-eah49b3g 56 3 people people NNS cord-300311-eah49b3g 56 4 with with IN cord-300311-eah49b3g 56 5 asthma asthma NN cord-300311-eah49b3g 56 6 , , , cord-300311-eah49b3g 56 7 RSV RSV NNP cord-300311-eah49b3g 56 8 also also RB cord-300311-eah49b3g 56 9 may may MD cord-300311-eah49b3g 56 10 play play VB cord-300311-eah49b3g 56 11 an an DT cord-300311-eah49b3g 56 12 important important JJ cord-300311-eah49b3g 56 13 role role NN cord-300311-eah49b3g 56 14 [ [ -LRB- cord-300311-eah49b3g 56 15 25 25 CD cord-300311-eah49b3g 56 16 ] ] -RRB- cord-300311-eah49b3g 56 17 . . . cord-300311-eah49b3g 57 1 A a DT cord-300311-eah49b3g 57 2 connection connection NN cord-300311-eah49b3g 57 3 has have VBZ cord-300311-eah49b3g 57 4 been be VBN cord-300311-eah49b3g 57 5 suggested suggest VBN cord-300311-eah49b3g 57 6 between between IN cord-300311-eah49b3g 57 7 bronchiolitis bronchiolitis NN cord-300311-eah49b3g 57 8 caused cause VBN cord-300311-eah49b3g 57 9 by by IN cord-300311-eah49b3g 57 10 RSV RSV NNP cord-300311-eah49b3g 57 11 infection infection NN cord-300311-eah49b3g 57 12 in in IN cord-300311-eah49b3g 57 13 childhood childhood NN cord-300311-eah49b3g 57 14 and and CC cord-300311-eah49b3g 57 15 the the DT cord-300311-eah49b3g 57 16 development development NN cord-300311-eah49b3g 57 17 of of IN cord-300311-eah49b3g 57 18 asthma asthma NN cord-300311-eah49b3g 57 19 [ [ -LRB- cord-300311-eah49b3g 57 20 26 26 CD cord-300311-eah49b3g 57 21 ] ] -RRB- cord-300311-eah49b3g 57 22 . . . cord-300311-eah49b3g 58 1 Against against IN cord-300311-eah49b3g 58 2 this this DT cord-300311-eah49b3g 58 3 background background NN cord-300311-eah49b3g 58 4 , , , cord-300311-eah49b3g 58 5 a a DT cord-300311-eah49b3g 58 6 vaccine vaccine NN cord-300311-eah49b3g 58 7 for for IN cord-300311-eah49b3g 58 8 RSV RSV NNP cord-300311-eah49b3g 58 9 may may MD cord-300311-eah49b3g 58 10 not not RB cord-300311-eah49b3g 58 11 only only RB cord-300311-eah49b3g 58 12 prevent prevent VB cord-300311-eah49b3g 58 13 exacerbations exacerbation NNS cord-300311-eah49b3g 58 14 but but CC cord-300311-eah49b3g 58 15 may may MD cord-300311-eah49b3g 58 16 also also RB cord-300311-eah49b3g 58 17 prevent prevent VB cord-300311-eah49b3g 58 18 the the DT cord-300311-eah49b3g 58 19 development development NN cord-300311-eah49b3g 58 20 of of IN cord-300311-eah49b3g 58 21 asthma asthma NN cord-300311-eah49b3g 58 22 later later RB cord-300311-eah49b3g 58 23 on on RB cord-300311-eah49b3g 58 24 . . . cord-300311-eah49b3g 59 1 However however RB cord-300311-eah49b3g 59 2 , , , cord-300311-eah49b3g 59 3 in in IN cord-300311-eah49b3g 59 4 the the DT cord-300311-eah49b3g 59 5 1960s 1960 NNS cord-300311-eah49b3g 59 6 an an DT cord-300311-eah49b3g 59 7 experimental experimental JJ cord-300311-eah49b3g 59 8 vaccine vaccine NN cord-300311-eah49b3g 59 9 unfortunately unfortunately RB cord-300311-eah49b3g 59 10 had have VBD cord-300311-eah49b3g 59 11 serious serious JJ cord-300311-eah49b3g 59 12 adverse adverse JJ cord-300311-eah49b3g 59 13 effects effect NNS cord-300311-eah49b3g 59 14 by by IN cord-300311-eah49b3g 59 15 increasing increase VBG cord-300311-eah49b3g 59 16 the the DT cord-300311-eah49b3g 59 17 clinical clinical JJ cord-300311-eah49b3g 59 18 symptoms symptom NNS cord-300311-eah49b3g 59 19 of of IN cord-300311-eah49b3g 59 20 naturally naturally RB cord-300311-eah49b3g 59 21 acquired acquire VBN cord-300311-eah49b3g 59 22 RSV RSV NNP cord-300311-eah49b3g 59 23 infections infection NNS cord-300311-eah49b3g 59 24 . . . cord-300311-eah49b3g 60 1 Several several JJ cord-300311-eah49b3g 60 2 other other JJ cord-300311-eah49b3g 60 3 vaccines vaccine NNS cord-300311-eah49b3g 60 4 are be VBP cord-300311-eah49b3g 60 5 being be VBG cord-300311-eah49b3g 60 6 tested test VBN cord-300311-eah49b3g 60 7 [ [ -LRB- cord-300311-eah49b3g 60 8 27 27 CD cord-300311-eah49b3g 60 9 ] ] -RRB- cord-300311-eah49b3g 60 10 , , , cord-300311-eah49b3g 60 11 and and CC cord-300311-eah49b3g 60 12 despite despite IN cord-300311-eah49b3g 60 13 the the DT cord-300311-eah49b3g 60 14 initial initial JJ cord-300311-eah49b3g 60 15 problems problem NNS cord-300311-eah49b3g 60 16 it -PRON- PRP cord-300311-eah49b3g 60 17 is be VBZ cord-300311-eah49b3g 60 18 believed believe VBN cord-300311-eah49b3g 60 19 that that IN cord-300311-eah49b3g 60 20 a a DT cord-300311-eah49b3g 60 21 vaccine vaccine NN cord-300311-eah49b3g 60 22 for for IN cord-300311-eah49b3g 60 23 routine routine JJ cord-300311-eah49b3g 60 24 immunization immunization NN cord-300311-eah49b3g 60 25 may may MD cord-300311-eah49b3g 60 26 be be VB cord-300311-eah49b3g 60 27 available available JJ cord-300311-eah49b3g 60 28 within within IN cord-300311-eah49b3g 60 29 the the DT cord-300311-eah49b3g 60 30 next next JJ cord-300311-eah49b3g 60 31 decade decade NN cord-300311-eah49b3g 60 32 [ [ -LRB- cord-300311-eah49b3g 60 33 22 22 CD cord-300311-eah49b3g 60 34 ] ] -RRB- cord-300311-eah49b3g 60 35 . . . cord-300311-eah49b3g 61 1 The the DT cord-300311-eah49b3g 61 2 influenza influenza NN cord-300311-eah49b3g 61 3 viruses virus NNS cord-300311-eah49b3g 61 4 are be VBP cord-300311-eah49b3g 61 5 classified classify VBN cord-300311-eah49b3g 61 6 in in IN cord-300311-eah49b3g 61 7 three three CD cord-300311-eah49b3g 61 8 genera genus NNS cord-300311-eah49b3g 61 9 , , , cord-300311-eah49b3g 61 10 labeled label VBN cord-300311-eah49b3g 61 11 A A NNP cord-300311-eah49b3g 61 12 , , , cord-300311-eah49b3g 61 13 B b NN cord-300311-eah49b3g 61 14 , , , cord-300311-eah49b3g 61 15 and and CC cord-300311-eah49b3g 62 1 C. C. NNP cord-300311-eah49b3g 62 2 Only Only NNP cord-300311-eah49b3g 62 3 types type VBZ cord-300311-eah49b3g 62 4 A a NN cord-300311-eah49b3g 62 5 and and CC cord-300311-eah49b3g 62 6 B b NN cord-300311-eah49b3g 62 7 cause cause VB cord-300311-eah49b3g 62 8 considerable considerable JJ cord-300311-eah49b3g 62 9 epidemics epidemic NNS cord-300311-eah49b3g 62 10 . . . cord-300311-eah49b3g 63 1 Every every DT cord-300311-eah49b3g 63 2 year year NN cord-300311-eah49b3g 63 3 influenza influenza NN cord-300311-eah49b3g 63 4 viruses virus NNS cord-300311-eah49b3g 63 5 change change VBP cord-300311-eah49b3g 63 6 their -PRON- PRP$ cord-300311-eah49b3g 63 7 genome genome NN cord-300311-eah49b3g 63 8 partially partially RB cord-300311-eah49b3g 63 9 , , , cord-300311-eah49b3g 63 10 which which WDT cord-300311-eah49b3g 63 11 is be VBZ cord-300311-eah49b3g 63 12 called call VBN cord-300311-eah49b3g 63 13 an an DT cord-300311-eah49b3g 63 14 antigenic antigenic JJ cord-300311-eah49b3g 63 15 drift drift NN cord-300311-eah49b3g 63 16 . . . cord-300311-eah49b3g 64 1 Because because IN cord-300311-eah49b3g 64 2 of of IN cord-300311-eah49b3g 64 3 different different JJ cord-300311-eah49b3g 64 4 subtypes subtype NNS cord-300311-eah49b3g 64 5 and and CC cord-300311-eah49b3g 64 6 antigenic antigenic JJ cord-300311-eah49b3g 64 7 drift drift NN cord-300311-eah49b3g 64 8 , , , cord-300311-eah49b3g 64 9 formerly formerly RB cord-300311-eah49b3g 64 10 built build VBN cord-300311-eah49b3g 64 11 - - HYPH cord-300311-eah49b3g 64 12 up up RP cord-300311-eah49b3g 64 13 natural natural JJ cord-300311-eah49b3g 64 14 immunity immunity NN cord-300311-eah49b3g 64 15 or or CC cord-300311-eah49b3g 64 16 vaccine vaccine NN cord-300311-eah49b3g 64 17 - - HYPH cord-300311-eah49b3g 64 18 initiated initiate VBN cord-300311-eah49b3g 64 19 immunity immunity NN cord-300311-eah49b3g 64 20 will will MD cord-300311-eah49b3g 64 21 not not RB cord-300311-eah49b3g 64 22 provide provide VB cord-300311-eah49b3g 64 23 protection protection NN cord-300311-eah49b3g 64 24 throughout throughout IN cord-300311-eah49b3g 64 25 successive successive JJ cord-300311-eah49b3g 64 26 seasons season NNS cord-300311-eah49b3g 64 27 . . . cord-300311-eah49b3g 65 1 There there EX cord-300311-eah49b3g 65 2 are be VBP cord-300311-eah49b3g 65 3 three three CD cord-300311-eah49b3g 65 4 types type NNS cord-300311-eah49b3g 65 5 of of IN cord-300311-eah49b3g 65 6 influenza influenza NN cord-300311-eah49b3g 65 7 A a DT cord-300311-eah49b3g 65 8 virus virus NN cord-300311-eah49b3g 65 9 known know VBN cord-300311-eah49b3g 65 10 to to TO cord-300311-eah49b3g 65 11 have have VB cord-300311-eah49b3g 65 12 infected infect VBN cord-300311-eah49b3g 65 13 humans human NNS cord-300311-eah49b3g 65 14 and and CC cord-300311-eah49b3g 65 15 to to TO cord-300311-eah49b3g 65 16 have have VB cord-300311-eah49b3g 65 17 transmitted transmit VBN cord-300311-eah49b3g 65 18 from from IN cord-300311-eah49b3g 65 19 human human JJ cord-300311-eah49b3g 65 20 to to IN cord-300311-eah49b3g 65 21 human human NN cord-300311-eah49b3g 65 22 : : : cord-300311-eah49b3g 65 23 H1N1 H1N1 NNP cord-300311-eah49b3g 65 24 , , , cord-300311-eah49b3g 65 25 H2N2 H2N2 NNP cord-300311-eah49b3g 65 26 , , , cord-300311-eah49b3g 65 27 and and CC cord-300311-eah49b3g 65 28 H3N2 H3N2 NNP cord-300311-eah49b3g 65 29 . . . cord-300311-eah49b3g 66 1 However however RB cord-300311-eah49b3g 66 2 , , , cord-300311-eah49b3g 66 3 water water NN cord-300311-eah49b3g 66 4 birds bird NNS cord-300311-eah49b3g 66 5 carry carry VBP cord-300311-eah49b3g 66 6 and and CC cord-300311-eah49b3g 66 7 are be VBP cord-300311-eah49b3g 66 8 infected infect VBN cord-300311-eah49b3g 66 9 with with IN cord-300311-eah49b3g 66 10 about about RB cord-300311-eah49b3g 66 11 15 15 CD cord-300311-eah49b3g 66 12 different different JJ cord-300311-eah49b3g 66 13 H h NN cord-300311-eah49b3g 66 14 - - HYPH cord-300311-eah49b3g 66 15 types type NNS cord-300311-eah49b3g 66 16 . . . cord-300311-eah49b3g 67 1 Infections infection NNS cord-300311-eah49b3g 67 2 can can MD cord-300311-eah49b3g 67 3 spread spread VB cord-300311-eah49b3g 67 4 from from IN cord-300311-eah49b3g 67 5 these these DT cord-300311-eah49b3g 67 6 birds bird NNS cord-300311-eah49b3g 67 7 to to IN cord-300311-eah49b3g 67 8 poultry poultry NN cord-300311-eah49b3g 67 9 , , , cord-300311-eah49b3g 67 10 swine swine NN cord-300311-eah49b3g 67 11 , , , cord-300311-eah49b3g 67 12 and and CC cord-300311-eah49b3g 67 13 other other JJ cord-300311-eah49b3g 67 14 animals animal NNS cord-300311-eah49b3g 67 15 living live VBG cord-300311-eah49b3g 67 16 more more RBR cord-300311-eah49b3g 67 17 closely closely RB cord-300311-eah49b3g 67 18 to to IN cord-300311-eah49b3g 67 19 humans human NNS cord-300311-eah49b3g 67 20 . . . cord-300311-eah49b3g 68 1 By by IN cord-300311-eah49b3g 68 2 mixing mix VBG cord-300311-eah49b3g 68 3 infections infection NNS cord-300311-eah49b3g 68 4 , , , cord-300311-eah49b3g 68 5 new new JJ cord-300311-eah49b3g 68 6 subtypes subtype NNS cord-300311-eah49b3g 68 7 can can MD cord-300311-eah49b3g 68 8 develop develop VB cord-300311-eah49b3g 68 9 ( ( -LRB- cord-300311-eah49b3g 68 10 antigenic antigenic JJ cord-300311-eah49b3g 68 11 shift shift NN cord-300311-eah49b3g 68 12 ) ) -RRB- cord-300311-eah49b3g 68 13 . . . cord-300311-eah49b3g 69 1 If if IN cord-300311-eah49b3g 69 2 a a DT cord-300311-eah49b3g 69 3 new new JJ cord-300311-eah49b3g 69 4 subtype subtype NN cord-300311-eah49b3g 69 5 has have VBZ cord-300311-eah49b3g 69 6 the the DT cord-300311-eah49b3g 69 7 ability ability NN cord-300311-eah49b3g 69 8 to to TO cord-300311-eah49b3g 69 9 infect infect VB cord-300311-eah49b3g 69 10 humans human NNS cord-300311-eah49b3g 69 11 and and CC cord-300311-eah49b3g 69 12 disseminate disseminate VB cord-300311-eah49b3g 69 13 , , , cord-300311-eah49b3g 69 14 a a DT cord-300311-eah49b3g 69 15 pandemic pandemic NN cord-300311-eah49b3g 69 16 could could MD cord-300311-eah49b3g 69 17 occur occur VB cord-300311-eah49b3g 69 18 . . . cord-300311-eah49b3g 70 1 This this DT cord-300311-eah49b3g 70 2 is be VBZ cord-300311-eah49b3g 70 3 an an DT cord-300311-eah49b3g 70 4 often often RB cord-300311-eah49b3g 70 5 expressed express VBN cord-300311-eah49b3g 70 6 fear fear NN cord-300311-eah49b3g 70 7 in in IN cord-300311-eah49b3g 70 8 the the DT cord-300311-eah49b3g 70 9 case case NN cord-300311-eah49b3g 70 10 of of IN cord-300311-eah49b3g 70 11 the the DT cord-300311-eah49b3g 70 12 H5N1 H5N1 NNP cord-300311-eah49b3g 70 13 influenza influenza NN cord-300311-eah49b3g 70 14 virus virus NN cord-300311-eah49b3g 70 15 . . . cord-300311-eah49b3g 71 1 Influenza influenza NN cord-300311-eah49b3g 71 2 is be VBZ cord-300311-eah49b3g 71 3 the the DT cord-300311-eah49b3g 71 4 only only JJ cord-300311-eah49b3g 71 5 lower low JJR cord-300311-eah49b3g 71 6 respiratory respiratory JJ cord-300311-eah49b3g 71 7 tract tract NN cord-300311-eah49b3g 71 8 infection infection NN cord-300311-eah49b3g 71 9 in in IN cord-300311-eah49b3g 71 10 humans human NNS cord-300311-eah49b3g 71 11 for for IN cord-300311-eah49b3g 71 12 which which WDT cord-300311-eah49b3g 71 13 a a DT cord-300311-eah49b3g 71 14 vaccine vaccine NN cord-300311-eah49b3g 71 15 has have VBZ cord-300311-eah49b3g 71 16 existed exist VBN cord-300311-eah49b3g 71 17 for for IN cord-300311-eah49b3g 71 18 decades decade NNS cord-300311-eah49b3g 71 19 . . . cord-300311-eah49b3g 72 1 Inactivated inactivate VBN cord-300311-eah49b3g 72 2 vaccines vaccine NNS cord-300311-eah49b3g 72 3 , , , cord-300311-eah49b3g 72 4 delivered deliver VBN cord-300311-eah49b3g 72 5 by by IN cord-300311-eah49b3g 72 6 subcutaneous subcutaneous JJ cord-300311-eah49b3g 72 7 or or CC cord-300311-eah49b3g 72 8 intramuscular intramuscular JJ cord-300311-eah49b3g 72 9 injection injection NN cord-300311-eah49b3g 72 10 , , , cord-300311-eah49b3g 72 11 are be VBP cord-300311-eah49b3g 72 12 widely widely RB cord-300311-eah49b3g 72 13 used use VBN cord-300311-eah49b3g 72 14 for for IN cord-300311-eah49b3g 72 15 the the DT cord-300311-eah49b3g 72 16 prevention prevention NN cord-300311-eah49b3g 72 17 of of IN cord-300311-eah49b3g 72 18 influenza influenza NN cord-300311-eah49b3g 72 19 . . . cord-300311-eah49b3g 73 1 The the DT cord-300311-eah49b3g 73 2 guidelines guideline NNS cord-300311-eah49b3g 73 3 of of IN cord-300311-eah49b3g 73 4 most most JJS cord-300311-eah49b3g 73 5 Western western JJ cord-300311-eah49b3g 73 6 countries country NNS cord-300311-eah49b3g 73 7 advise advise VBP cord-300311-eah49b3g 73 8 to to TO cord-300311-eah49b3g 73 9 vaccinate vaccinate VB cord-300311-eah49b3g 73 10 patients patient NNS cord-300311-eah49b3g 73 11 with with IN cord-300311-eah49b3g 73 12 asthma asthma NN cord-300311-eah49b3g 73 13 [ [ -LRB- cord-300311-eah49b3g 73 14 28 28 CD cord-300311-eah49b3g 73 15 ] ] -RRB- cord-300311-eah49b3g 73 16 . . . cord-300311-eah49b3g 74 1 Influenza influenza NN cord-300311-eah49b3g 74 2 is be VBZ cord-300311-eah49b3g 74 3 one one CD cord-300311-eah49b3g 74 4 of of IN cord-300311-eah49b3g 74 5 the the DT cord-300311-eah49b3g 74 6 common common JJ cord-300311-eah49b3g 74 7 respiratory respiratory JJ cord-300311-eah49b3g 74 8 tract tract NN cord-300311-eah49b3g 74 9 infections infection NNS cord-300311-eah49b3g 74 10 in in IN cord-300311-eah49b3g 74 11 humans human NNS cord-300311-eah49b3g 74 12 [ [ -LRB- cord-300311-eah49b3g 74 13 29 29 CD cord-300311-eah49b3g 74 14 ] ] -RRB- cord-300311-eah49b3g 74 15 and and CC cord-300311-eah49b3g 74 16 according accord VBG cord-300311-eah49b3g 74 17 to to IN cord-300311-eah49b3g 74 18 the the DT cord-300311-eah49b3g 74 19 World World NNP cord-300311-eah49b3g 74 20 Health Health NNP cord-300311-eah49b3g 74 21 Organization Organization NNP cord-300311-eah49b3g 74 22 a a DT cord-300311-eah49b3g 74 23 yearly yearly JJ cord-300311-eah49b3g 74 24 public public JJ cord-300311-eah49b3g 74 25 health health NN cord-300311-eah49b3g 74 26 problem problem NN cord-300311-eah49b3g 74 27 [ [ -LRB- cord-300311-eah49b3g 74 28 30 30 CD cord-300311-eah49b3g 74 29 ] ] -RRB- cord-300311-eah49b3g 74 30 . . . cord-300311-eah49b3g 75 1 Every every DT cord-300311-eah49b3g 75 2 year year NN cord-300311-eah49b3g 75 3 , , , cord-300311-eah49b3g 75 4 influenza influenza NN cord-300311-eah49b3g 75 5 centers center NNS cord-300311-eah49b3g 75 6 worldwide worldwide RB cord-300311-eah49b3g 75 7 report report NN cord-300311-eah49b3g 75 8 influenza influenza NN cord-300311-eah49b3g 75 9 activity activity NN cord-300311-eah49b3g 75 10 and and CC cord-300311-eah49b3g 75 11 the the DT cord-300311-eah49b3g 75 12 occurrence occurrence NN cord-300311-eah49b3g 75 13 of of IN cord-300311-eah49b3g 75 14 influenza influenza NN cord-300311-eah49b3g 75 15 - - HYPH cord-300311-eah49b3g 75 16 like like JJ cord-300311-eah49b3g 75 17 illnesses illness NNS cord-300311-eah49b3g 75 18 ( ( -LRB- cord-300311-eah49b3g 75 19 ILI ILI NNP cord-300311-eah49b3g 75 20 ) ) -RRB- cord-300311-eah49b3g 75 21 as as RB cord-300311-eah49b3g 75 22 well well RB cord-300311-eah49b3g 75 23 as as IN cord-300311-eah49b3g 75 24 data datum NNS cord-300311-eah49b3g 75 25 on on IN cord-300311-eah49b3g 75 26 subsequent subsequent JJ cord-300311-eah49b3g 75 27 health health NN cord-300311-eah49b3g 75 28 care care NN cord-300311-eah49b3g 75 29 use use NN cord-300311-eah49b3g 75 30 . . . cord-300311-eah49b3g 76 1 But but CC cord-300311-eah49b3g 76 2 , , , cord-300311-eah49b3g 76 3 many many JJ cord-300311-eah49b3g 76 4 viruses virus NNS cord-300311-eah49b3g 76 5 can can MD cord-300311-eah49b3g 76 6 cause cause VB cord-300311-eah49b3g 76 7 ILI ILI NNP cord-300311-eah49b3g 76 8 and and CC cord-300311-eah49b3g 76 9 thus thus RB cord-300311-eah49b3g 76 10 a a DT cord-300311-eah49b3g 76 11 direct direct JJ cord-300311-eah49b3g 76 12 relation relation NN cord-300311-eah49b3g 76 13 between between IN cord-300311-eah49b3g 76 14 influenza influenza NN cord-300311-eah49b3g 76 15 virus virus NN cord-300311-eah49b3g 76 16 and and CC cord-300311-eah49b3g 76 17 symptomatic symptomatic JJ cord-300311-eah49b3g 76 18 disease disease NN cord-300311-eah49b3g 76 19 is be VBZ cord-300311-eah49b3g 76 20 difficult difficult JJ cord-300311-eah49b3g 76 21 to to TO cord-300311-eah49b3g 76 22 determine determine VB cord-300311-eah49b3g 76 23 . . . cord-300311-eah49b3g 77 1 In in IN cord-300311-eah49b3g 77 2 published publish VBN cord-300311-eah49b3g 77 3 articles article NNS cord-300311-eah49b3g 77 4 isolated isolate VBN cord-300311-eah49b3g 77 5 serologic serologic JJ cord-300311-eah49b3g 77 6 incidence incidence NN cord-300311-eah49b3g 77 7 rates rate NNS cord-300311-eah49b3g 77 8 , , , cord-300311-eah49b3g 77 9 rates rate NNS cord-300311-eah49b3g 77 10 of of IN cord-300311-eah49b3g 77 11 ILI ILI NNP cord-300311-eah49b3g 77 12 , , , cord-300311-eah49b3g 77 13 and and CC cord-300311-eah49b3g 77 14 the the DT cord-300311-eah49b3g 77 15 occurrence occurrence NN cord-300311-eah49b3g 77 16 of of IN cord-300311-eah49b3g 77 17 complications complication NNS cord-300311-eah49b3g 77 18 are be VBP cord-300311-eah49b3g 77 19 often often RB cord-300311-eah49b3g 77 20 used use VBN cord-300311-eah49b3g 77 21 as as IN cord-300311-eah49b3g 77 22 proxy proxy JJ cord-300311-eah49b3g 77 23 measures measure NNS cord-300311-eah49b3g 77 24 for for IN cord-300311-eah49b3g 77 25 influenza influenza NN cord-300311-eah49b3g 77 26 - - HYPH cord-300311-eah49b3g 77 27 related relate VBN cord-300311-eah49b3g 77 28 clinical clinical JJ cord-300311-eah49b3g 77 29 illness illness NN cord-300311-eah49b3g 77 30 . . . cord-300311-eah49b3g 78 1 Confirmation confirmation NN cord-300311-eah49b3g 78 2 of of IN cord-300311-eah49b3g 78 3 influenza influenza NN cord-300311-eah49b3g 78 4 at at IN cord-300311-eah49b3g 78 5 an an DT cord-300311-eah49b3g 78 6 individual individual JJ cord-300311-eah49b3g 78 7 level level NN cord-300311-eah49b3g 78 8 is be VBZ cord-300311-eah49b3g 78 9 not not RB cord-300311-eah49b3g 78 10 provided provide VBN cord-300311-eah49b3g 78 11 in in IN cord-300311-eah49b3g 78 12 these these DT cord-300311-eah49b3g 78 13 large large JJ cord-300311-eah49b3g 78 14 observational observational JJ cord-300311-eah49b3g 78 15 studies study NNS cord-300311-eah49b3g 78 16 [ [ -LRB- cord-300311-eah49b3g 78 17 11 11 CD cord-300311-eah49b3g 78 18 , , , cord-300311-eah49b3g 78 19 12 12 CD cord-300311-eah49b3g 78 20 , , , cord-300311-eah49b3g 78 21 31 31 CD cord-300311-eah49b3g 78 22 , , , cord-300311-eah49b3g 78 23 32 32 CD cord-300311-eah49b3g 78 24 ] ] -RRB- cord-300311-eah49b3g 78 25 . . . cord-300311-eah49b3g 79 1 However however RB cord-300311-eah49b3g 79 2 , , , cord-300311-eah49b3g 79 3 when when WRB cord-300311-eah49b3g 79 4 influenza influenza NN cord-300311-eah49b3g 79 5 infection infection NN cord-300311-eah49b3g 79 6 is be VBZ cord-300311-eah49b3g 79 7 confirmed confirm VBN cord-300311-eah49b3g 79 8 by by IN cord-300311-eah49b3g 79 9 laboratory laboratory NN cord-300311-eah49b3g 79 10 tests test NNS cord-300311-eah49b3g 79 11 as as IN cord-300311-eah49b3g 79 12 in in IN cord-300311-eah49b3g 79 13 trials trial NNS cord-300311-eah49b3g 79 14 or or CC cord-300311-eah49b3g 79 15 smaller small JJR cord-300311-eah49b3g 79 16 observational observational JJ cord-300311-eah49b3g 79 17 studies study NNS cord-300311-eah49b3g 79 18 , , , cord-300311-eah49b3g 79 19 the the DT cord-300311-eah49b3g 79 20 clinical clinical JJ cord-300311-eah49b3g 79 21 impact impact NN cord-300311-eah49b3g 79 22 of of IN cord-300311-eah49b3g 79 23 influenza influenza NN cord-300311-eah49b3g 79 24 seems seem VBZ cord-300311-eah49b3g 79 25 to to TO cord-300311-eah49b3g 79 26 be be VB cord-300311-eah49b3g 79 27 limited limit VBN cord-300311-eah49b3g 79 28 [ [ -LRB- cord-300311-eah49b3g 79 29 4,6,33,34•,35 4,6,33,34•,35 CD cord-300311-eah49b3g 79 30 ] ] -RRB- cord-300311-eah49b3g 79 31 . . . cord-300311-eah49b3g 80 1 Incidence incidence NN cord-300311-eah49b3g 80 2 of of IN cord-300311-eah49b3g 80 3 influenza influenza NN cord-300311-eah49b3g 80 4 varies vary VBZ cord-300311-eah49b3g 80 5 from from IN cord-300311-eah49b3g 80 6 place place NN cord-300311-eah49b3g 80 7 to to IN cord-300311-eah49b3g 80 8 place place NN cord-300311-eah49b3g 80 9 and and CC cord-300311-eah49b3g 80 10 from from IN cord-300311-eah49b3g 80 11 season season NN cord-300311-eah49b3g 80 12 to to IN cord-300311-eah49b3g 80 13 season season NN cord-300311-eah49b3g 80 14 . . . cord-300311-eah49b3g 81 1 National national JJ cord-300311-eah49b3g 81 2 and and CC cord-300311-eah49b3g 81 3 international international JJ cord-300311-eah49b3g 81 4 influenza influenza NN cord-300311-eah49b3g 81 5 centers center NNS cord-300311-eah49b3g 81 6 and and CC cord-300311-eah49b3g 81 7 organizations organization NNS cord-300311-eah49b3g 81 8 worldwide worldwide RB cord-300311-eah49b3g 81 9 report report NN cord-300311-eah49b3g 81 10 incidence incidence NN cord-300311-eah49b3g 81 11 figures figure NNS cord-300311-eah49b3g 81 12 . . . cord-300311-eah49b3g 82 1 Usually usually RB cord-300311-eah49b3g 82 2 , , , cord-300311-eah49b3g 82 3 these these DT cord-300311-eah49b3g 82 4 figures figure NNS cord-300311-eah49b3g 82 5 are be VBP cord-300311-eah49b3g 82 6 measured measure VBN cord-300311-eah49b3g 82 7 in in IN cord-300311-eah49b3g 82 8 an an DT cord-300311-eah49b3g 82 9 indirect indirect JJ cord-300311-eah49b3g 82 10 way way NN cord-300311-eah49b3g 82 11 and and CC cord-300311-eah49b3g 82 12 relate relate VB cord-300311-eah49b3g 82 13 to to IN cord-300311-eah49b3g 82 14 excess excess JJ cord-300311-eah49b3g 82 15 hospitalizations hospitalization NNS cord-300311-eah49b3g 82 16 or or CC cord-300311-eah49b3g 82 17 mortality mortality NN cord-300311-eah49b3g 82 18 due due IN cord-300311-eah49b3g 82 19 to to IN cord-300311-eah49b3g 82 20 pneumonia pneumonia NN cord-300311-eah49b3g 82 21 and and CC cord-300311-eah49b3g 82 22 influenza influenza NN cord-300311-eah49b3g 82 23 or or CC cord-300311-eah49b3g 82 24 excess excess JJ cord-300311-eah49b3g 82 25 health health NN cord-300311-eah49b3g 82 26 care care NN cord-300311-eah49b3g 82 27 use use NN cord-300311-eah49b3g 82 28 . . . cord-300311-eah49b3g 83 1 Seasonal seasonal JJ cord-300311-eah49b3g 83 2 incidence incidence NN cord-300311-eah49b3g 83 3 figures figure NNS cord-300311-eah49b3g 83 4 for for IN cord-300311-eah49b3g 83 5 ILI ILI NNP cord-300311-eah49b3g 83 6 of of IN cord-300311-eah49b3g 83 7 20 20 CD cord-300311-eah49b3g 83 8 % % NN cord-300311-eah49b3g 83 9 to to TO cord-300311-eah49b3g 83 10 30 30 CD cord-300311-eah49b3g 83 11 % % NN cord-300311-eah49b3g 83 12 are be VBP cord-300311-eah49b3g 83 13 not not RB cord-300311-eah49b3g 83 14 uncommon uncommon JJ cord-300311-eah49b3g 83 15 . . . cord-300311-eah49b3g 84 1 However however RB cord-300311-eah49b3g 84 2 , , , cord-300311-eah49b3g 84 3 symptomatic symptomatic JJ cord-300311-eah49b3g 84 4 disease disease NN cord-300311-eah49b3g 84 5 should should MD cord-300311-eah49b3g 84 6 preferably preferably RB cord-300311-eah49b3g 84 7 be be VB cord-300311-eah49b3g 84 8 corroborated corroborate VBN cord-300311-eah49b3g 84 9 by by IN cord-300311-eah49b3g 84 10 a a DT cord-300311-eah49b3g 84 11 positive positive JJ cord-300311-eah49b3g 84 12 laboratory laboratory NN cord-300311-eah49b3g 84 13 test test NN cord-300311-eah49b3g 84 14 [ [ -LRB- cord-300311-eah49b3g 84 15 36 36 CD cord-300311-eah49b3g 84 16 ] ] -RRB- cord-300311-eah49b3g 84 17 . . . cord-300311-eah49b3g 85 1 Only only RB cord-300311-eah49b3g 85 2 in in IN cord-300311-eah49b3g 85 3 children child NNS cord-300311-eah49b3g 85 4 do do VBP cord-300311-eah49b3g 85 5 such such JJ cord-300311-eah49b3g 85 6 figures figure NNS cord-300311-eah49b3g 85 7 seem seem VBP cord-300311-eah49b3g 85 8 to to TO cord-300311-eah49b3g 85 9 be be VB cord-300311-eah49b3g 85 10 available available JJ cord-300311-eah49b3g 85 11 for for IN cord-300311-eah49b3g 85 12 a a DT cord-300311-eah49b3g 85 13 considerable considerable JJ cord-300311-eah49b3g 85 14 number number NN cord-300311-eah49b3g 85 15 of of IN cord-300311-eah49b3g 85 16 years year NNS cord-300311-eah49b3g 85 17 [ [ -LRB- cord-300311-eah49b3g 85 18 37 37 CD cord-300311-eah49b3g 85 19 ] ] -RRB- cord-300311-eah49b3g 85 20 . . . cord-300311-eah49b3g 86 1 Based base VBN cord-300311-eah49b3g 86 2 on on IN cord-300311-eah49b3g 86 3 these these DT cord-300311-eah49b3g 86 4 data datum NNS cord-300311-eah49b3g 86 5 , , , cord-300311-eah49b3g 86 6 the the DT cord-300311-eah49b3g 86 7 average average JJ cord-300311-eah49b3g 86 8 incidence incidence NN cord-300311-eah49b3g 86 9 , , , cord-300311-eah49b3g 86 10 depending depend VBG cord-300311-eah49b3g 86 11 on on IN cord-300311-eah49b3g 86 12 age age NN cord-300311-eah49b3g 86 13 category category NN cord-300311-eah49b3g 86 14 , , , cord-300311-eah49b3g 86 15 is be VBZ cord-300311-eah49b3g 86 16 between between IN cord-300311-eah49b3g 86 17 5 5 CD cord-300311-eah49b3g 86 18 % % NN cord-300311-eah49b3g 86 19 and and CC cord-300311-eah49b3g 86 20 9.5 9.5 CD cord-300311-eah49b3g 86 21 % % NN cord-300311-eah49b3g 86 22 . . . cord-300311-eah49b3g 87 1 The the DT cord-300311-eah49b3g 87 2 clinical clinical JJ cord-300311-eah49b3g 87 3 picture picture NN cord-300311-eah49b3g 87 4 is be VBZ cord-300311-eah49b3g 87 5 usually usually RB cord-300311-eah49b3g 87 6 described describe VBN cord-300311-eah49b3g 87 7 as as IN cord-300311-eah49b3g 87 8 mild mild JJ cord-300311-eah49b3g 87 9 [ [ -LRB- cord-300311-eah49b3g 87 10 37 37 CD cord-300311-eah49b3g 87 11 ] ] -RRB- cord-300311-eah49b3g 87 12 . . . cord-300311-eah49b3g 88 1 Regarding regard VBG cord-300311-eah49b3g 88 2 the the DT cord-300311-eah49b3g 88 3 fluctuating fluctuate VBG cord-300311-eah49b3g 88 4 incidence incidence NN cord-300311-eah49b3g 88 5 of of IN cord-300311-eah49b3g 88 6 ILI ILI NNP cord-300311-eah49b3g 88 7 reported report VBD cord-300311-eah49b3g 88 8 , , , cord-300311-eah49b3g 88 9 it -PRON- PRP cord-300311-eah49b3g 88 10 is be VBZ cord-300311-eah49b3g 88 11 likely likely JJ cord-300311-eah49b3g 88 12 that that IN cord-300311-eah49b3g 88 13 in in IN cord-300311-eah49b3g 88 14 adults adult NNS cord-300311-eah49b3g 88 15 , , , cord-300311-eah49b3g 88 16 the the DT cord-300311-eah49b3g 88 17 average average JJ cord-300311-eah49b3g 88 18 incidence incidence NN cord-300311-eah49b3g 88 19 does do VBZ cord-300311-eah49b3g 88 20 not not RB cord-300311-eah49b3g 88 21 exceed exceed VB cord-300311-eah49b3g 88 22 these these DT cord-300311-eah49b3g 88 23 figures figure NNS cord-300311-eah49b3g 88 24 . . . cord-300311-eah49b3g 89 1 Comparable comparable JJ cord-300311-eah49b3g 89 2 figures figure NNS cord-300311-eah49b3g 89 3 on on IN cord-300311-eah49b3g 89 4 the the DT cord-300311-eah49b3g 89 5 incidence incidence NN cord-300311-eah49b3g 89 6 in in IN cord-300311-eah49b3g 89 7 asthmatics asthmatic NNS cord-300311-eah49b3g 89 8 are be VBP cord-300311-eah49b3g 89 9 even even RB cord-300311-eah49b3g 89 10 scarcer scarce JJR cord-300311-eah49b3g 89 11 . . . cord-300311-eah49b3g 90 1 The the DT cord-300311-eah49b3g 90 2 proportion proportion NN cord-300311-eah49b3g 90 3 of of IN cord-300311-eah49b3g 90 4 asthma asthma NN cord-300311-eah49b3g 90 5 exacerbations exacerbation NNS cord-300311-eah49b3g 90 6 due due JJ cord-300311-eah49b3g 90 7 to to IN cord-300311-eah49b3g 90 8 influenza influenza NN cord-300311-eah49b3g 90 9 reported report VBN cord-300311-eah49b3g 90 10 in in IN cord-300311-eah49b3g 90 11 asthmatic asthmatic JJ cord-300311-eah49b3g 90 12 children child NNS cord-300311-eah49b3g 90 13 were be VBD cord-300311-eah49b3g 90 14 18 18 CD cord-300311-eah49b3g 90 15 % % NN cord-300311-eah49b3g 90 16 and and CC cord-300311-eah49b3g 90 17 5 5 CD cord-300311-eah49b3g 90 18 % % NN cord-300311-eah49b3g 90 19 [ [ -LRB- cord-300311-eah49b3g 90 20 4,34• 4,34• CD cord-300311-eah49b3g 90 21 ] ] -RRB- cord-300311-eah49b3g 90 22 . . . cord-300311-eah49b3g 91 1 No no DT cord-300311-eah49b3g 91 2 severe severe JJ cord-300311-eah49b3g 91 3 complications complication NNS cord-300311-eah49b3g 91 4 ( ( -LRB- cord-300311-eah49b3g 91 5 eg eg IN cord-300311-eah49b3g 91 6 , , , cord-300311-eah49b3g 91 7 hospitalizations hospitalization NNS cord-300311-eah49b3g 91 8 ) ) -RRB- cord-300311-eah49b3g 91 9 were be VBD cord-300311-eah49b3g 91 10 found find VBN cord-300311-eah49b3g 91 11 in in IN cord-300311-eah49b3g 91 12 these these DT cord-300311-eah49b3g 91 13 two two CD cord-300311-eah49b3g 91 14 studies study NNS cord-300311-eah49b3g 91 15 . . . cord-300311-eah49b3g 92 1 The the DT cord-300311-eah49b3g 92 2 effect effect NN cord-300311-eah49b3g 92 3 of of IN cord-300311-eah49b3g 92 4 influenza influenza NN cord-300311-eah49b3g 92 5 vaccination vaccination NN cord-300311-eah49b3g 92 6 in in IN cord-300311-eah49b3g 92 7 preventing prevent VBG cord-300311-eah49b3g 92 8 clinical clinical JJ cord-300311-eah49b3g 92 9 symptoms symptom NNS cord-300311-eah49b3g 92 10 is be VBZ cord-300311-eah49b3g 92 11 a a DT cord-300311-eah49b3g 92 12 much much RB cord-300311-eah49b3g 92 13 - - HYPH cord-300311-eah49b3g 92 14 debated debate VBN cord-300311-eah49b3g 92 15 item item NN cord-300311-eah49b3g 92 16 . . . cord-300311-eah49b3g 93 1 A a DT cord-300311-eah49b3g 93 2 number number NN cord-300311-eah49b3g 93 3 of of IN cord-300311-eah49b3g 93 4 reviews review NNS cord-300311-eah49b3g 93 5 indicate indicate VBP cord-300311-eah49b3g 93 6 that that IN cord-300311-eah49b3g 93 7 ( ( -LRB- cord-300311-eah49b3g 93 8 inactivated inactivate VBN cord-300311-eah49b3g 93 9 ) ) -RRB- cord-300311-eah49b3g 93 10 vaccines vaccine NNS cord-300311-eah49b3g 93 11 can can MD cord-300311-eah49b3g 93 12 have have VB cord-300311-eah49b3g 93 13 an an DT cord-300311-eah49b3g 93 14 efficacy efficacy NN cord-300311-eah49b3g 93 15 of of IN cord-300311-eah49b3g 93 16 70 70 CD cord-300311-eah49b3g 93 17 % % NN cord-300311-eah49b3g 93 18 in in IN cord-300311-eah49b3g 93 19 reducing reduce VBG cord-300311-eah49b3g 93 20 serologically serologically RB cord-300311-eah49b3g 93 21 confirmed confirm VBN cord-300311-eah49b3g 93 22 cases case NNS cord-300311-eah49b3g 93 23 of of IN cord-300311-eah49b3g 93 24 influenza influenza NN cord-300311-eah49b3g 93 25 . . . cord-300311-eah49b3g 94 1 However however RB cord-300311-eah49b3g 94 2 , , , cord-300311-eah49b3g 94 3 when when WRB cord-300311-eah49b3g 94 4 using use VBG cord-300311-eah49b3g 94 5 symptom symptom NN cord-300311-eah49b3g 94 6 - - HYPH cord-300311-eah49b3g 94 7 based base VBN cord-300311-eah49b3g 94 8 outcomes outcome NNS cord-300311-eah49b3g 94 9 the the DT cord-300311-eah49b3g 94 10 vaccines vaccine NNS cord-300311-eah49b3g 94 11 showed show VBD cord-300311-eah49b3g 94 12 an an DT cord-300311-eah49b3g 94 13 efficacy efficacy NN cord-300311-eah49b3g 94 14 of of IN cord-300311-eah49b3g 94 15 only only RB cord-300311-eah49b3g 94 16 about about RB cord-300311-eah49b3g 94 17 25 25 CD cord-300311-eah49b3g 94 18 % % NN cord-300311-eah49b3g 94 19 [ [ -LRB- cord-300311-eah49b3g 94 20 38 38 CD cord-300311-eah49b3g 94 21 ] ] -RRB- cord-300311-eah49b3g 94 22 [ [ -LRB- cord-300311-eah49b3g 94 23 39 39 CD cord-300311-eah49b3g 94 24 ] ] -RRB- cord-300311-eah49b3g 94 25 [ [ -LRB- cord-300311-eah49b3g 94 26 40 40 CD cord-300311-eah49b3g 94 27 ] ] -RRB- cord-300311-eah49b3g 94 28 . . . cord-300311-eah49b3g 95 1 Moreover moreover RB cord-300311-eah49b3g 95 2 , , , cord-300311-eah49b3g 95 3 in in IN cord-300311-eah49b3g 95 4 case case NN cord-300311-eah49b3g 95 5 of of IN cord-300311-eah49b3g 95 6 a a DT cord-300311-eah49b3g 95 7 mismatch mismatch NN cord-300311-eah49b3g 95 8 between between IN cord-300311-eah49b3g 95 9 the the DT cord-300311-eah49b3g 95 10 vaccine vaccine NN cord-300311-eah49b3g 95 11 composition composition NN cord-300311-eah49b3g 95 12 and and CC cord-300311-eah49b3g 95 13 the the DT cord-300311-eah49b3g 95 14 natural natural JJ cord-300311-eah49b3g 95 15 virus virus NN cord-300311-eah49b3g 95 16 , , , cord-300311-eah49b3g 95 17 efficacy efficacy NN cord-300311-eah49b3g 95 18 will will MD cord-300311-eah49b3g 95 19 be be VB cord-300311-eah49b3g 95 20 much much RB cord-300311-eah49b3g 95 21 lower low JJR cord-300311-eah49b3g 95 22 or or CC cord-300311-eah49b3g 95 23 absent absent JJ cord-300311-eah49b3g 95 24 . . . cord-300311-eah49b3g 96 1 Over over IN cord-300311-eah49b3g 96 2 the the DT cord-300311-eah49b3g 96 3 past past JJ cord-300311-eah49b3g 96 4 years year NNS cord-300311-eah49b3g 96 5 , , , cord-300311-eah49b3g 96 6 live live VBP cord-300311-eah49b3g 96 7 attenuated attenuated JJ cord-300311-eah49b3g 96 8 vaccines vaccine NNS cord-300311-eah49b3g 96 9 have have VBP cord-300311-eah49b3g 96 10 been be VBN cord-300311-eah49b3g 96 11 developed develop VBN cord-300311-eah49b3g 96 12 , , , cord-300311-eah49b3g 96 13 tested test VBN cord-300311-eah49b3g 96 14 , , , cord-300311-eah49b3g 96 15 and and CC cord-300311-eah49b3g 96 16 used use VBN cord-300311-eah49b3g 96 17 for for IN cord-300311-eah49b3g 96 18 intranasal intranasal NNP cord-300311-eah49b3g 96 19 administration administration NN cord-300311-eah49b3g 96 20 . . . cord-300311-eah49b3g 97 1 The the DT cord-300311-eah49b3g 97 2 less less RBR cord-300311-eah49b3g 97 3 invasive invasive JJ cord-300311-eah49b3g 97 4 route route NN cord-300311-eah49b3g 97 5 , , , cord-300311-eah49b3g 97 6 of of IN cord-300311-eah49b3g 97 7 course course NN cord-300311-eah49b3g 97 8 , , , cord-300311-eah49b3g 97 9 is be VBZ cord-300311-eah49b3g 97 10 a a DT cord-300311-eah49b3g 97 11 benefit benefit NN cord-300311-eah49b3g 97 12 in in IN cord-300311-eah49b3g 97 13 administering administer VBG cord-300311-eah49b3g 97 14 the the DT cord-300311-eah49b3g 97 15 vaccine vaccine NN cord-300311-eah49b3g 97 16 . . . cord-300311-eah49b3g 98 1 Besides besides RB cord-300311-eah49b3g 98 2 , , , cord-300311-eah49b3g 98 3 the the DT cord-300311-eah49b3g 98 4 extra extra JJ cord-300311-eah49b3g 98 5 local local JJ cord-300311-eah49b3g 98 6 immune immune JJ cord-300311-eah49b3g 98 7 response response NN cord-300311-eah49b3g 98 8 that that WDT cord-300311-eah49b3g 98 9 is be VBZ cord-300311-eah49b3g 98 10 activated activate VBN cord-300311-eah49b3g 98 11 is be VBZ cord-300311-eah49b3g 98 12 a a DT cord-300311-eah49b3g 98 13 potential potential JJ cord-300311-eah49b3g 98 14 benefit benefit NN cord-300311-eah49b3g 98 15 . . . cord-300311-eah49b3g 99 1 Yet yet RB cord-300311-eah49b3g 99 2 , , , cord-300311-eah49b3g 99 3 even even RB cord-300311-eah49b3g 99 4 then then RB cord-300311-eah49b3g 99 5 there there EX cord-300311-eah49b3g 99 6 still still RB cord-300311-eah49b3g 99 7 remains remain VBZ cord-300311-eah49b3g 99 8 a a DT cord-300311-eah49b3g 99 9 striking striking JJ cord-300311-eah49b3g 99 10 difference difference NN cord-300311-eah49b3g 99 11 between between IN cord-300311-eah49b3g 99 12 efficacy efficacy NN cord-300311-eah49b3g 99 13 and and CC cord-300311-eah49b3g 99 14 clinical clinical JJ cord-300311-eah49b3g 99 15 effectiveness effectiveness NN cord-300311-eah49b3g 99 16 [ [ -LRB- cord-300311-eah49b3g 99 17 39 39 CD cord-300311-eah49b3g 99 18 ] ] -RRB- cord-300311-eah49b3g 99 19 . . . cord-300311-eah49b3g 100 1 Currently currently RB cord-300311-eah49b3g 100 2 , , , cord-300311-eah49b3g 100 3 animal animal NN cord-300311-eah49b3g 100 4 research research NN cord-300311-eah49b3g 100 5 is be VBZ cord-300311-eah49b3g 100 6 being be VBG cord-300311-eah49b3g 100 7 done do VBN cord-300311-eah49b3g 100 8 into into IN cord-300311-eah49b3g 100 9 the the DT cord-300311-eah49b3g 100 10 development development NN cord-300311-eah49b3g 100 11 of of IN cord-300311-eah49b3g 100 12 vaccines vaccine NNS cord-300311-eah49b3g 100 13 that that WDT cord-300311-eah49b3g 100 14 induce induce VBP cord-300311-eah49b3g 100 15 broad broad JJ cord-300311-eah49b3g 100 16 - - HYPH cord-300311-eah49b3g 100 17 spectrum spectrum NN cord-300311-eah49b3g 100 18 and and CC cord-300311-eah49b3g 100 19 long long RB cord-300311-eah49b3g 100 20 - - HYPH cord-300311-eah49b3g 100 21 lasting last VBG cord-300311-eah49b3g 100 22 immune immune JJ cord-300311-eah49b3g 100 23 response response NN cord-300311-eah49b3g 100 24 , , , cord-300311-eah49b3g 100 25 which which WDT cord-300311-eah49b3g 100 26 , , , cord-300311-eah49b3g 100 27 if if IN cord-300311-eah49b3g 100 28 successful successful JJ cord-300311-eah49b3g 100 29 , , , cord-300311-eah49b3g 100 30 would would MD cord-300311-eah49b3g 100 31 alter alter VB cord-300311-eah49b3g 100 32 the the DT cord-300311-eah49b3g 100 33 prospects prospect NNS cord-300311-eah49b3g 100 34 of of IN cord-300311-eah49b3g 100 35 the the DT cord-300311-eah49b3g 100 36 current current JJ cord-300311-eah49b3g 100 37 influenza influenza NN cord-300311-eah49b3g 100 38 vaccination vaccination NN cord-300311-eah49b3g 100 39 programs program NNS cord-300311-eah49b3g 100 40 . . . cord-300311-eah49b3g 101 1 In in IN cord-300311-eah49b3g 101 2 asthmatics asthmatic NNS cord-300311-eah49b3g 101 3 , , , cord-300311-eah49b3g 101 4 observational observational JJ cord-300311-eah49b3g 101 5 studies study NNS cord-300311-eah49b3g 101 6 report report VBP cord-300311-eah49b3g 101 7 varying vary VBG cord-300311-eah49b3g 101 8 and and CC cord-300311-eah49b3g 101 9 sometimes sometimes RB cord-300311-eah49b3g 101 10 even even RB cord-300311-eah49b3g 101 11 contradictory contradictory JJ cord-300311-eah49b3g 101 12 outcomes outcome NNS cord-300311-eah49b3g 101 13 [ [ -LRB- cord-300311-eah49b3g 101 14 41 41 CD cord-300311-eah49b3g 101 15 ] ] -RRB- cord-300311-eah49b3g 101 16 [ [ -LRB- cord-300311-eah49b3g 101 17 42 42 CD cord-300311-eah49b3g 101 18 ] ] -RRB- cord-300311-eah49b3g 101 19 [ [ -LRB- cord-300311-eah49b3g 101 20 43 43 CD cord-300311-eah49b3g 101 21 ] ] -RRB- cord-300311-eah49b3g 101 22 . . . cord-300311-eah49b3g 102 1 But but CC cord-300311-eah49b3g 102 2 clinical clinical JJ cord-300311-eah49b3g 102 3 efficacy efficacy NN cord-300311-eah49b3g 102 4 has have VBZ cord-300311-eah49b3g 102 5 not not RB cord-300311-eah49b3g 102 6 been be VBN cord-300311-eah49b3g 102 7 established establish VBN cord-300311-eah49b3g 102 8 yet yet RB cord-300311-eah49b3g 102 9 at at IN cord-300311-eah49b3g 102 10 the the DT cord-300311-eah49b3g 102 11 highest high JJS cord-300311-eah49b3g 102 12 level level NN cord-300311-eah49b3g 102 13 of of IN cord-300311-eah49b3g 102 14 evidence evidence NN cord-300311-eah49b3g 102 15 . . . cord-300311-eah49b3g 103 1 Uncertainty uncertainty NN cord-300311-eah49b3g 103 2 still still RB cord-300311-eah49b3g 103 3 remains remain VBZ cord-300311-eah49b3g 103 4 about about IN cord-300311-eah49b3g 103 5 the the DT cord-300311-eah49b3g 103 6 degree degree NN cord-300311-eah49b3g 103 7 of of IN cord-300311-eah49b3g 103 8 protection protection NN cord-300311-eah49b3g 103 9 vaccination vaccination NN cord-300311-eah49b3g 103 10 affords afford VBZ cord-300311-eah49b3g 103 11 against against IN cord-300311-eah49b3g 103 12 influenzarelated influenzarelate VBN cord-300311-eah49b3g 103 13 symptoms symptom NNS cord-300311-eah49b3g 103 14 such such JJ cord-300311-eah49b3g 103 15 as as IN cord-300311-eah49b3g 103 16 asthma asthma NN cord-300311-eah49b3g 103 17 exacerbations exacerbation NNS cord-300311-eah49b3g 103 18 [ [ -LRB- cord-300311-eah49b3g 103 19 44•• 44•• CD cord-300311-eah49b3g 103 20 ] ] -RRB- cord-300311-eah49b3g 103 21 . . . cord-300311-eah49b3g 104 1 In in IN cord-300311-eah49b3g 104 2 a a DT cord-300311-eah49b3g 104 3 recent recent JJ cord-300311-eah49b3g 104 4 study study NN cord-300311-eah49b3g 104 5 in in IN cord-300311-eah49b3g 104 6 children child NNS cord-300311-eah49b3g 104 7 with with IN cord-300311-eah49b3g 104 8 asthma asthma NN cord-300311-eah49b3g 104 9 , , , cord-300311-eah49b3g 104 10 no no DT cord-300311-eah49b3g 104 11 positive positive JJ cord-300311-eah49b3g 104 12 effect effect NN cord-300311-eah49b3g 104 13 of of IN cord-300311-eah49b3g 104 14 vaccination vaccination NN cord-300311-eah49b3g 104 15 was be VBD cord-300311-eah49b3g 104 16 found find VBN cord-300311-eah49b3g 104 17 [ [ -LRB- cord-300311-eah49b3g 104 18 34• 34• CD cord-300311-eah49b3g 104 19 ] ] -RRB- cord-300311-eah49b3g 104 20 . . . cord-300311-eah49b3g 105 1 However however RB cord-300311-eah49b3g 105 2 , , , cord-300311-eah49b3g 105 3 a a DT cord-300311-eah49b3g 105 4 distinct distinct JJ cord-300311-eah49b3g 105 5 effect effect NN cord-300311-eah49b3g 105 6 on on IN cord-300311-eah49b3g 105 7 quality quality NN cord-300311-eah49b3g 105 8 of of IN cord-300311-eah49b3g 105 9 life life NN cord-300311-eah49b3g 105 10 in in IN cord-300311-eah49b3g 105 11 influenza influenza NN cord-300311-eah49b3g 105 12 - - HYPH cord-300311-eah49b3g 105 13 related relate VBN cord-300311-eah49b3g 105 14 episodes episode NNS cord-300311-eah49b3g 105 15 in in IN cord-300311-eah49b3g 105 16 asthmatic asthmatic JJ cord-300311-eah49b3g 105 17 children child NNS cord-300311-eah49b3g 105 18 was be VBD cord-300311-eah49b3g 105 19 reported report VBN cord-300311-eah49b3g 105 20 [ [ -LRB- cord-300311-eah49b3g 105 21 6 6 CD cord-300311-eah49b3g 105 22 ] ] -RRB- cord-300311-eah49b3g 105 23 . . . cord-300311-eah49b3g 106 1 As as IN cord-300311-eah49b3g 106 2 for for IN cord-300311-eah49b3g 106 3 side side NN cord-300311-eah49b3g 106 4 effects effect NNS cord-300311-eah49b3g 106 5 and and CC cord-300311-eah49b3g 106 6 complications complication NNS cord-300311-eah49b3g 106 7 , , , cord-300311-eah49b3g 106 8 the the DT cord-300311-eah49b3g 106 9 evidence evidence NN cord-300311-eah49b3g 106 10 that that IN cord-300311-eah49b3g 106 11 influenza influenza NN cord-300311-eah49b3g 106 12 vaccination vaccination NN cord-300311-eah49b3g 106 13 is be VBZ cord-300311-eah49b3g 106 14 safe safe JJ cord-300311-eah49b3g 106 15 and and CC cord-300311-eah49b3g 106 16 well well RB cord-300311-eah49b3g 106 17 tolerated tolerate VBN cord-300311-eah49b3g 106 18 is be VBZ cord-300311-eah49b3g 106 19 extensive extensive JJ cord-300311-eah49b3g 106 20 [ [ -LRB- cord-300311-eah49b3g 106 21 44•• 44•• CD cord-300311-eah49b3g 106 22 ] ] -RRB- cord-300311-eah49b3g 106 23 . . . cord-300311-eah49b3g 107 1 Several several JJ cord-300311-eah49b3g 107 2 studies study NNS cord-300311-eah49b3g 107 3 have have VBP cord-300311-eah49b3g 107 4 addressed address VBN cord-300311-eah49b3g 107 5 the the DT cord-300311-eah49b3g 107 6 cost cost NN cord-300311-eah49b3g 107 7 - - HYPH cord-300311-eah49b3g 107 8 effectiveness effectiveness NN cord-300311-eah49b3g 107 9 of of IN cord-300311-eah49b3g 107 10 influenza influenza NN cord-300311-eah49b3g 107 11 vaccination vaccination NN cord-300311-eah49b3g 107 12 . . . cord-300311-eah49b3g 108 1 We -PRON- PRP cord-300311-eah49b3g 108 2 also also RB cord-300311-eah49b3g 108 3 identified identify VBD cord-300311-eah49b3g 108 4 one one CD cord-300311-eah49b3g 108 5 costeffectiveness costeffectiveness NN cord-300311-eah49b3g 108 6 study study NN cord-300311-eah49b3g 108 7 that that WDT cord-300311-eah49b3g 108 8 addressed address VBD cord-300311-eah49b3g 108 9 a a DT cord-300311-eah49b3g 108 10 hypothetical hypothetical JJ cord-300311-eah49b3g 108 11 RSV RSV NNP cord-300311-eah49b3g 108 12 vaccine vaccine NN cord-300311-eah49b3g 108 13 in in IN cord-300311-eah49b3g 108 14 elderly elderly JJ cord-300311-eah49b3g 108 15 people people NNS cord-300311-eah49b3g 108 16 [ [ -LRB- cord-300311-eah49b3g 108 17 45 45 CD cord-300311-eah49b3g 108 18 ] ] -RRB- cord-300311-eah49b3g 108 19 . . . cord-300311-eah49b3g 109 1 All all DT cord-300311-eah49b3g 109 2 cost cost NN cord-300311-eah49b3g 109 3 - - HYPH cord-300311-eah49b3g 109 4 effectiveness effectiveness NN cord-300311-eah49b3g 109 5 studies study NNS cord-300311-eah49b3g 109 6 are be VBP cord-300311-eah49b3g 109 7 based base VBN cord-300311-eah49b3g 109 8 on on IN cord-300311-eah49b3g 109 9 a a DT cord-300311-eah49b3g 109 10 population population NN cord-300311-eah49b3g 109 11 - - HYPH cord-300311-eah49b3g 109 12 wide wide JJ cord-300311-eah49b3g 109 13 use use NN cord-300311-eah49b3g 109 14 of of IN cord-300311-eah49b3g 109 15 the the DT cord-300311-eah49b3g 109 16 vaccines vaccine NNS cord-300311-eah49b3g 109 17 , , , cord-300311-eah49b3g 109 18 for for IN cord-300311-eah49b3g 109 19 example example NN cord-300311-eah49b3g 109 20 , , , cord-300311-eah49b3g 109 21 in in IN cord-300311-eah49b3g 109 22 preschool preschool NN cord-300311-eah49b3g 109 23 children child NNS cord-300311-eah49b3g 109 24 or or CC cord-300311-eah49b3g 109 25 elderly elderly JJ cord-300311-eah49b3g 109 26 persons person NNS cord-300311-eah49b3g 109 27 . . . cord-300311-eah49b3g 110 1 In in IN cord-300311-eah49b3g 110 2 all all DT cord-300311-eah49b3g 110 3 of of IN cord-300311-eah49b3g 110 4 these these DT cord-300311-eah49b3g 110 5 studies study NNS cord-300311-eah49b3g 110 6 , , , cord-300311-eah49b3g 110 7 the the DT cord-300311-eah49b3g 110 8 cost cost NN cord-300311-eah49b3g 110 9 - - HYPH cord-300311-eah49b3g 110 10 effectiveness effectiveness NN cord-300311-eah49b3g 110 11 of of IN cord-300311-eah49b3g 110 12 influenza influenza NN cord-300311-eah49b3g 110 13 vaccination vaccination NN cord-300311-eah49b3g 110 14 is be VBZ cord-300311-eah49b3g 110 15 based base VBN cord-300311-eah49b3g 110 16 on on IN cord-300311-eah49b3g 110 17 several several JJ cord-300311-eah49b3g 110 18 premises premise NNS cord-300311-eah49b3g 110 19 . . . cord-300311-eah49b3g 111 1 Often often RB cord-300311-eah49b3g 111 2 the the DT cord-300311-eah49b3g 111 3 incidence incidence NN cord-300311-eah49b3g 111 4 of of IN cord-300311-eah49b3g 111 5 influenza influenza NN cord-300311-eah49b3g 111 6 is be VBZ cord-300311-eah49b3g 111 7 approximated approximate VBN cord-300311-eah49b3g 111 8 by by IN cord-300311-eah49b3g 111 9 that that DT cord-300311-eah49b3g 111 10 of of IN cord-300311-eah49b3g 111 11 ILI ILI NNP cord-300311-eah49b3g 111 12 in in IN cord-300311-eah49b3g 111 13 epidemic epidemic NN cord-300311-eah49b3g 111 14 seasons season NNS cord-300311-eah49b3g 111 15 . . . cord-300311-eah49b3g 112 1 These these DT cord-300311-eah49b3g 112 2 figures figure NNS cord-300311-eah49b3g 112 3 certainly certainly RB cord-300311-eah49b3g 112 4 exceed exceed VBP cord-300311-eah49b3g 112 5 the the DT cord-300311-eah49b3g 112 6 average average JJ cord-300311-eah49b3g 112 7 incidence incidence NN cord-300311-eah49b3g 112 8 of of IN cord-300311-eah49b3g 112 9 influenza influenza NN cord-300311-eah49b3g 112 10 when when WRB cord-300311-eah49b3g 112 11 taking take VBG cord-300311-eah49b3g 112 12 into into IN cord-300311-eah49b3g 112 13 account account NN cord-300311-eah49b3g 112 14 the the DT cord-300311-eah49b3g 112 15 seasons season NNS cord-300311-eah49b3g 112 16 with with IN cord-300311-eah49b3g 112 17 low low JJ cord-300311-eah49b3g 112 18 or or CC cord-300311-eah49b3g 112 19 no no DT cord-300311-eah49b3g 112 20 influenza influenza NN cord-300311-eah49b3g 112 21 activity activity NN cord-300311-eah49b3g 112 22 . . . cord-300311-eah49b3g 113 1 Other other JJ cord-300311-eah49b3g 113 2 biases bias NNS cord-300311-eah49b3g 113 3 may may MD cord-300311-eah49b3g 113 4 be be VB cord-300311-eah49b3g 113 5 the the DT cord-300311-eah49b3g 113 6 target target NN cord-300311-eah49b3g 113 7 populations population NNS cord-300311-eah49b3g 113 8 and and CC cord-300311-eah49b3g 113 9 the the DT cord-300311-eah49b3g 113 10 definition definition NN cord-300311-eah49b3g 113 11 used use VBN cord-300311-eah49b3g 113 12 for for IN cord-300311-eah49b3g 113 13 influenza influenza NN cord-300311-eah49b3g 113 14 [ [ -LRB- cord-300311-eah49b3g 113 15 46 46 CD cord-300311-eah49b3g 113 16 ] ] -RRB- cord-300311-eah49b3g 113 17 . . . cord-300311-eah49b3g 114 1 In in IN cord-300311-eah49b3g 114 2 the the DT cord-300311-eah49b3g 114 3 elderly elderly JJ cord-300311-eah49b3g 114 4 cost cost NN cord-300311-eah49b3g 114 5 - - HYPH cord-300311-eah49b3g 114 6 effectiveness effectiveness NN cord-300311-eah49b3g 114 7 is be VBZ cord-300311-eah49b3g 114 8 globally globally RB cord-300311-eah49b3g 114 9 accepted accept VBN cord-300311-eah49b3g 114 10 [ [ -LRB- cord-300311-eah49b3g 114 11 47 47 CD cord-300311-eah49b3g 114 12 ] ] -RRB- cord-300311-eah49b3g 114 13 . . . cord-300311-eah49b3g 115 1 In in IN cord-300311-eah49b3g 115 2 either either DT cord-300311-eah49b3g 115 3 case case NN cord-300311-eah49b3g 115 4 , , , cord-300311-eah49b3g 115 5 population population NN cord-300311-eah49b3g 115 6 - - HYPH cord-300311-eah49b3g 115 7 wide wide JJ cord-300311-eah49b3g 115 8 cost cost NN cord-300311-eah49b3g 115 9 - - HYPH cord-300311-eah49b3g 115 10 effectiveness effectiveness NN cord-300311-eah49b3g 115 11 preventive preventive JJ cord-300311-eah49b3g 115 12 options option NNS cord-300311-eah49b3g 115 13 against against IN cord-300311-eah49b3g 115 14 influenza influenza NN cord-300311-eah49b3g 115 15 for for IN cord-300311-eah49b3g 115 16 healthy healthy JJ cord-300311-eah49b3g 115 17 adults adult NNS cord-300311-eah49b3g 115 18 14 14 CD cord-300311-eah49b3g 115 19 to to TO cord-300311-eah49b3g 115 20 60 60 CD cord-300311-eah49b3g 115 21 years year NNS cord-300311-eah49b3g 115 22 old old JJ cord-300311-eah49b3g 115 23 do do VBP cord-300311-eah49b3g 115 24 not not RB cord-300311-eah49b3g 115 25 seem seem VB cord-300311-eah49b3g 115 26 to to TO cord-300311-eah49b3g 115 27 be be VB cord-300311-eah49b3g 115 28 easily easily RB cord-300311-eah49b3g 115 29 achieved achieve VBN cord-300311-eah49b3g 115 30 , , , cord-300311-eah49b3g 115 31 and and CC cord-300311-eah49b3g 115 32 therefore therefore RB cord-300311-eah49b3g 115 33 some some DT cord-300311-eah49b3g 115 34 authors author NNS cord-300311-eah49b3g 115 35 have have VBP cord-300311-eah49b3g 115 36 suggested suggest VBN cord-300311-eah49b3g 115 37 that that IN cord-300311-eah49b3g 115 38 the the DT cord-300311-eah49b3g 115 39 most most RBS cord-300311-eah49b3g 115 40 cost cost NN cord-300311-eah49b3g 115 41 - - HYPH cord-300311-eah49b3g 115 42 effective effective JJ cord-300311-eah49b3g 115 43 option option NN cord-300311-eah49b3g 115 44 is be VBZ cord-300311-eah49b3g 115 45 not not RB cord-300311-eah49b3g 115 46 to to TO cord-300311-eah49b3g 115 47 take take VB cord-300311-eah49b3g 115 48 any any DT cord-300311-eah49b3g 115 49 action action NN cord-300311-eah49b3g 115 50 [ [ -LRB- cord-300311-eah49b3g 115 51 48 48 CD cord-300311-eah49b3g 115 52 ] ] -RRB- cord-300311-eah49b3g 115 53 . . . cord-300311-eah49b3g 116 1 For for IN cord-300311-eah49b3g 116 2 high high JJ cord-300311-eah49b3g 116 3 - - HYPH cord-300311-eah49b3g 116 4 risk risk NN cord-300311-eah49b3g 116 5 patients patient NNS cord-300311-eah49b3g 116 6 with with IN cord-300311-eah49b3g 116 7 chronic chronic JJ cord-300311-eah49b3g 116 8 respiratory respiratory JJ cord-300311-eah49b3g 116 9 conditions condition NNS cord-300311-eah49b3g 116 10 , , , cord-300311-eah49b3g 116 11 again again RB cord-300311-eah49b3g 116 12 , , , cord-300311-eah49b3g 116 13 in in IN cord-300311-eah49b3g 116 14 the the DT cord-300311-eah49b3g 116 15 elderly elderly JJ cord-300311-eah49b3g 116 16 cost cost NN cord-300311-eah49b3g 116 17 - - HYPH cord-300311-eah49b3g 116 18 effectiveness effectiveness NN cord-300311-eah49b3g 116 19 was be VBD cord-300311-eah49b3g 116 20 achieved achieve VBN cord-300311-eah49b3g 116 21 ; ; : cord-300311-eah49b3g 116 22 however however RB cord-300311-eah49b3g 116 23 , , , cord-300311-eah49b3g 116 24 this this DT cord-300311-eah49b3g 116 25 was be VBD cord-300311-eah49b3g 116 26 not not RB cord-300311-eah49b3g 116 27 the the DT cord-300311-eah49b3g 116 28 case case NN cord-300311-eah49b3g 116 29 for for IN cord-300311-eah49b3g 116 30 the the DT cord-300311-eah49b3g 116 31 18 18 CD cord-300311-eah49b3g 116 32 to to TO cord-300311-eah49b3g 116 33 65 65 CD cord-300311-eah49b3g 116 34 years year NNS cord-300311-eah49b3g 116 35 age age NN cord-300311-eah49b3g 116 36 category category NN cord-300311-eah49b3g 116 37 [ [ -LRB- cord-300311-eah49b3g 116 38 49 49 CD cord-300311-eah49b3g 116 39 , , , cord-300311-eah49b3g 116 40 50 50 CD cord-300311-eah49b3g 116 41 ] ] -RRB- cord-300311-eah49b3g 116 42 . . . cord-300311-eah49b3g 117 1 In in IN cord-300311-eah49b3g 117 2 children child NNS cord-300311-eah49b3g 117 3 with with IN cord-300311-eah49b3g 117 4 high high JJ cord-300311-eah49b3g 117 5 - - HYPH cord-300311-eah49b3g 117 6 risk risk NN cord-300311-eah49b3g 117 7 conditions condition NNS cord-300311-eah49b3g 117 8 the the DT cord-300311-eah49b3g 117 9 use use NN cord-300311-eah49b3g 117 10 of of IN cord-300311-eah49b3g 117 11 influenza influenza NN cord-300311-eah49b3g 117 12 vaccination vaccination NN cord-300311-eah49b3g 117 13 was be VBD cord-300311-eah49b3g 117 14 calculated calculate VBN cord-300311-eah49b3g 117 15 to to TO cord-300311-eah49b3g 117 16 be be VB cord-300311-eah49b3g 117 17 cost cost NN cord-300311-eah49b3g 117 18 - - HYPH cord-300311-eah49b3g 117 19 effective effective JJ cord-300311-eah49b3g 117 20 . . . cord-300311-eah49b3g 118 1 However however RB cord-300311-eah49b3g 118 2 , , , cord-300311-eah49b3g 118 3 this this DT cord-300311-eah49b3g 118 4 study study NN cord-300311-eah49b3g 118 5 assumed assume VBD cord-300311-eah49b3g 118 6 a a DT cord-300311-eah49b3g 118 7 much much RB cord-300311-eah49b3g 118 8 higher high JJR cord-300311-eah49b3g 118 9 incidence incidence NN cord-300311-eah49b3g 118 10 and and CC cord-300311-eah49b3g 118 11 a a DT cord-300311-eah49b3g 118 12 far far RB cord-300311-eah49b3g 118 13 more more RBR cord-300311-eah49b3g 118 14 favorable favorable JJ cord-300311-eah49b3g 118 15 effectiveness effectiveness NN cord-300311-eah49b3g 118 16 of of IN cord-300311-eah49b3g 118 17 influenza influenza NN cord-300311-eah49b3g 118 18 vaccination vaccination NN cord-300311-eah49b3g 118 19 than than IN cord-300311-eah49b3g 118 20 described describe VBN cord-300311-eah49b3g 118 21 above above IN cord-300311-eah49b3g 118 22 [ [ -LRB- cord-300311-eah49b3g 118 23 50 50 CD cord-300311-eah49b3g 118 24 ] ] -RRB- cord-300311-eah49b3g 118 25 . . . cord-300311-eah49b3g 119 1 The the DT cord-300311-eah49b3g 119 2 role role NN cord-300311-eah49b3g 119 3 of of IN cord-300311-eah49b3g 119 4 virus virus NN cord-300311-eah49b3g 119 5 vaccination vaccination NN cord-300311-eah49b3g 119 6 in in IN cord-300311-eah49b3g 119 7 patients patient NNS cord-300311-eah49b3g 119 8 with with IN cord-300311-eah49b3g 119 9 asthma asthma NN cord-300311-eah49b3g 119 10 at at IN cord-300311-eah49b3g 119 11 this this DT cord-300311-eah49b3g 119 12 moment moment NN cord-300311-eah49b3g 119 13 and and CC cord-300311-eah49b3g 119 14 in in IN cord-300311-eah49b3g 119 15 the the DT cord-300311-eah49b3g 119 16 near near JJ cord-300311-eah49b3g 119 17 future future NN cord-300311-eah49b3g 119 18 seems seem VBZ cord-300311-eah49b3g 119 19 to to TO cord-300311-eah49b3g 119 20 be be VB cord-300311-eah49b3g 119 21 limited limit VBN cord-300311-eah49b3g 119 22 ( ( -LRB- cord-300311-eah49b3g 119 23 Table table NN cord-300311-eah49b3g 119 24 1 1 CD cord-300311-eah49b3g 119 25 ) ) -RRB- cord-300311-eah49b3g 119 26 . . . cord-300311-eah49b3g 120 1 Currently currently RB cord-300311-eah49b3g 120 2 , , , cord-300311-eah49b3g 120 3 vaccines vaccine NNS cord-300311-eah49b3g 120 4 are be VBP cord-300311-eah49b3g 120 5 available available JJ cord-300311-eah49b3g 120 6 for for IN cord-300311-eah49b3g 120 7 routine routine JJ cord-300311-eah49b3g 120 8 use use NN cord-300311-eah49b3g 120 9 only only RB cord-300311-eah49b3g 120 10 for for IN cord-300311-eah49b3g 120 11 influenza influenza NN cord-300311-eah49b3g 120 12 . . . cord-300311-eah49b3g 121 1 However however RB cord-300311-eah49b3g 121 2 , , , cord-300311-eah49b3g 121 3 because because IN cord-300311-eah49b3g 121 4 of of IN cord-300311-eah49b3g 121 5 a a DT cord-300311-eah49b3g 121 6 lack lack NN cord-300311-eah49b3g 121 7 of of IN cord-300311-eah49b3g 121 8 clinical clinical JJ cord-300311-eah49b3g 121 9 effectiveness effectiveness NN cord-300311-eah49b3g 121 10 , , , cord-300311-eah49b3g 121 11 the the DT cord-300311-eah49b3g 121 12 natural natural JJ cord-300311-eah49b3g 121 13 antigenic antigenic JJ cord-300311-eah49b3g 121 14 variations variation NNS cord-300311-eah49b3g 121 15 of of IN cord-300311-eah49b3g 121 16 the the DT cord-300311-eah49b3g 121 17 influenza influenza NN cord-300311-eah49b3g 121 18 virus virus NN cord-300311-eah49b3g 121 19 , , , cord-300311-eah49b3g 121 20 and and CC cord-300311-eah49b3g 121 21 the the DT cord-300311-eah49b3g 121 22 low low JJ cord-300311-eah49b3g 121 23 average average JJ cord-300311-eah49b3g 121 24 incidence incidence NN cord-300311-eah49b3g 121 25 of of IN cord-300311-eah49b3g 121 26 influenza influenza NN cord-300311-eah49b3g 121 27 , , , cord-300311-eah49b3g 121 28 cost cost NN cord-300311-eah49b3g 121 29 - - HYPH cord-300311-eah49b3g 121 30 effectiveness effectiveness NN cord-300311-eah49b3g 121 31 in in IN cord-300311-eah49b3g 121 32 children child NNS cord-300311-eah49b3g 121 33 and and CC cord-300311-eah49b3g 121 34 adults adult NNS cord-300311-eah49b3g 121 35 with with IN cord-300311-eah49b3g 121 36 asthma asthma NN cord-300311-eah49b3g 121 37 will will MD cord-300311-eah49b3g 121 38 not not RB cord-300311-eah49b3g 121 39 be be VB cord-300311-eah49b3g 121 40 easily easily RB cord-300311-eah49b3g 121 41 achieved achieve VBN cord-300311-eah49b3g 121 42 if if IN cord-300311-eah49b3g 121 43 vaccination vaccination NN cord-300311-eah49b3g 121 44 has have VBZ cord-300311-eah49b3g 121 45 to to TO cord-300311-eah49b3g 121 46 be be VB cord-300311-eah49b3g 121 47 delivered deliver VBN cord-300311-eah49b3g 121 48 annually annually RB cord-300311-eah49b3g 121 49 . . . cord-300311-eah49b3g 122 1 As as IN cord-300311-eah49b3g 122 2 for for IN cord-300311-eah49b3g 122 3 the the DT cord-300311-eah49b3g 122 4 other other JJ cord-300311-eah49b3g 122 5 viruses virus NNS cord-300311-eah49b3g 122 6 that that WDT cord-300311-eah49b3g 122 7 play play VBP cord-300311-eah49b3g 122 8 an an DT cord-300311-eah49b3g 122 9 important important JJ cord-300311-eah49b3g 122 10 role role NN cord-300311-eah49b3g 122 11 in in IN cord-300311-eah49b3g 122 12 the the DT cord-300311-eah49b3g 122 13 complications complication NNS cord-300311-eah49b3g 122 14 of of IN cord-300311-eah49b3g 122 15 patients patient NNS cord-300311-eah49b3g 122 16 with with IN cord-300311-eah49b3g 122 17 asthma asthma NN cord-300311-eah49b3g 122 18 , , , cord-300311-eah49b3g 122 19 many many JJ cord-300311-eah49b3g 122 20 hurdles hurdle NNS cord-300311-eah49b3g 122 21 remain remain VBP cord-300311-eah49b3g 122 22 to to TO cord-300311-eah49b3g 122 23 be be VB cord-300311-eah49b3g 122 24 overcome overcome VBN cord-300311-eah49b3g 122 25 . . . cord-300311-eah49b3g 123 1 For for IN cord-300311-eah49b3g 123 2 RSV RSV NNP cord-300311-eah49b3g 123 3 , , , cord-300311-eah49b3g 123 4 the the DT cord-300311-eah49b3g 123 5 first first JJ cord-300311-eah49b3g 123 6 experiences experience NNS cord-300311-eah49b3g 123 7 with with IN cord-300311-eah49b3g 123 8 vaccines vaccine NNS cord-300311-eah49b3g 123 9 were be VBD cord-300311-eah49b3g 123 10 a a DT cord-300311-eah49b3g 123 11 major major JJ cord-300311-eah49b3g 123 12 disappointment disappointment NN cord-300311-eah49b3g 123 13 . . . cord-300311-eah49b3g 124 1 In in IN cord-300311-eah49b3g 124 2 the the DT cord-300311-eah49b3g 124 3 case case NN cord-300311-eah49b3g 124 4 of of IN cord-300311-eah49b3g 124 5 coronaviruses coronaviruse NNS cord-300311-eah49b3g 124 6 , , , cord-300311-eah49b3g 124 7 attention attention NN cord-300311-eah49b3g 124 8 is be VBZ cord-300311-eah49b3g 124 9 understandably understandably RB cord-300311-eah49b3g 124 10 focused focused JJ cord-300311-eah49b3g 124 11 on on IN cord-300311-eah49b3g 124 12 a a DT cord-300311-eah49b3g 124 13 vaccine vaccine NN cord-300311-eah49b3g 124 14 for for IN cord-300311-eah49b3g 124 15 the the DT cord-300311-eah49b3g 124 16 prevention prevention NN cord-300311-eah49b3g 124 17 of of IN cord-300311-eah49b3g 124 18 SARS SARS NNP cord-300311-eah49b3g 124 19 . . . cord-300311-eah49b3g 125 1 As as IN cord-300311-eah49b3g 125 2 for for IN cord-300311-eah49b3g 125 3 rhinoviruses rhinovirus NNS cord-300311-eah49b3g 125 4 , , , cord-300311-eah49b3g 125 5 the the DT cord-300311-eah49b3g 125 6 major major JJ cord-300311-eah49b3g 125 7 cause cause NN cord-300311-eah49b3g 125 8 of of IN cord-300311-eah49b3g 125 9 asthma asthma NN cord-300311-eah49b3g 125 10 exacerbations exacerbation NNS cord-300311-eah49b3g 125 11 , , , cord-300311-eah49b3g 125 12 because because IN cord-300311-eah49b3g 125 13 of of IN cord-300311-eah49b3g 125 14 the the DT cord-300311-eah49b3g 125 15 amount amount NN cord-300311-eah49b3g 125 16 of of IN cord-300311-eah49b3g 125 17 subspecies subspecies NN cord-300311-eah49b3g 125 18 a a DT cord-300311-eah49b3g 125 19 vaccine vaccine NN cord-300311-eah49b3g 125 20 will will MD cord-300311-eah49b3g 125 21 not not RB cord-300311-eah49b3g 125 22 be be VB cord-300311-eah49b3g 125 23 available available JJ cord-300311-eah49b3g 125 24 in in IN cord-300311-eah49b3g 125 25 the the DT cord-300311-eah49b3g 125 26 near near JJ cord-300311-eah49b3g 125 27 future future NN cord-300311-eah49b3g 125 28 . . . cord-300311-eah49b3g 126 1 Of of RB cord-300311-eah49b3g 126 2 course course RB cord-300311-eah49b3g 126 3 other other JJ cord-300311-eah49b3g 126 4 therapies therapy NNS cord-300311-eah49b3g 126 5 , , , cord-300311-eah49b3g 126 6 such such JJ cord-300311-eah49b3g 126 7 as as IN cord-300311-eah49b3g 126 8 antiviral antiviral JJ cord-300311-eah49b3g 126 9 medication medication NN cord-300311-eah49b3g 126 10 or or CC cord-300311-eah49b3g 126 11 immunoglobulin immunoglobulin NN cord-300311-eah49b3g 126 12 , , , cord-300311-eah49b3g 126 13 are be VBP cord-300311-eah49b3g 126 14 used use VBN cord-300311-eah49b3g 126 15 and and CC cord-300311-eah49b3g 126 16 are be VBP cord-300311-eah49b3g 126 17 sometimes sometimes RB cord-300311-eah49b3g 126 18 effective effective JJ cord-300311-eah49b3g 126 19 in in IN cord-300311-eah49b3g 126 20 reducing reduce VBG cord-300311-eah49b3g 126 21 complications complication NNS cord-300311-eah49b3g 126 22 . . . cord-300311-eah49b3g 127 1 But but CC cord-300311-eah49b3g 127 2 , , , cord-300311-eah49b3g 127 3 the the DT cord-300311-eah49b3g 127 4 therapeutic therapeutic JJ cord-300311-eah49b3g 127 5 use use NN cord-300311-eah49b3g 127 6 of of IN cord-300311-eah49b3g 127 7 these these DT cord-300311-eah49b3g 127 8 treatments treatment NNS cord-300311-eah49b3g 127 9 is be VBZ cord-300311-eah49b3g 127 10 limited limit VBN cord-300311-eah49b3g 127 11 because because IN cord-300311-eah49b3g 127 12 they -PRON- PRP cord-300311-eah49b3g 127 13 are be VBP cord-300311-eah49b3g 127 14 often often RB cord-300311-eah49b3g 127 15 expensive expensive JJ cord-300311-eah49b3g 127 16 and and CC cord-300311-eah49b3g 127 17 should should MD cord-300311-eah49b3g 127 18 be be VB cord-300311-eah49b3g 127 19 used use VBN cord-300311-eah49b3g 127 20 only only RB cord-300311-eah49b3g 127 21 when when WRB cord-300311-eah49b3g 127 22 there there EX cord-300311-eah49b3g 127 23 is be VBZ cord-300311-eah49b3g 127 24 proof proof NN cord-300311-eah49b3g 127 25 of of IN cord-300311-eah49b3g 127 26 the the DT cord-300311-eah49b3g 127 27 agent agent NN cord-300311-eah49b3g 127 28 that that WDT cord-300311-eah49b3g 127 29 is be VBZ cord-300311-eah49b3g 127 30 causing cause VBG cord-300311-eah49b3g 127 31 the the DT cord-300311-eah49b3g 127 32 patient patient NN cord-300311-eah49b3g 127 33 's 's POS cord-300311-eah49b3g 127 34 symptoms symptom NNS cord-300311-eah49b3g 127 35 . . . cord-300311-eah49b3g 128 1 For for IN cord-300311-eah49b3g 128 2 prophylactic prophylactic JJ cord-300311-eah49b3g 128 3 use use VBP cord-300311-eah49b3g 128 4 their -PRON- PRP$ cord-300311-eah49b3g 128 5 cost cost NN cord-300311-eah49b3g 128 6 is be VBZ cord-300311-eah49b3g 128 7 a a DT cord-300311-eah49b3g 128 8 major major JJ cord-300311-eah49b3g 128 9 problem problem NN cord-300311-eah49b3g 128 10 . . . cord-300311-eah49b3g 129 1 Yet yet RB cord-300311-eah49b3g 129 2 , , , cord-300311-eah49b3g 129 3 the the DT cord-300311-eah49b3g 129 4 role role NN cord-300311-eah49b3g 129 5 of of IN cord-300311-eah49b3g 129 6 the the DT cord-300311-eah49b3g 129 7 clinician clinician NN cord-300311-eah49b3g 129 8 in in IN cord-300311-eah49b3g 129 9 patients patient NNS cord-300311-eah49b3g 129 10 with with IN cord-300311-eah49b3g 129 11 asthma asthma NN cord-300311-eah49b3g 129 12 experiencing experience VBG cord-300311-eah49b3g 129 13 the the DT cord-300311-eah49b3g 129 14 threat threat NN cord-300311-eah49b3g 129 15 of of IN cord-300311-eah49b3g 129 16 an an DT cord-300311-eah49b3g 129 17 exacerbation exacerbation NN cord-300311-eah49b3g 129 18 with with IN cord-300311-eah49b3g 129 19 its -PRON- PRP$ cord-300311-eah49b3g 129 20 complications complication NNS cord-300311-eah49b3g 129 21 is be VBZ cord-300311-eah49b3g 129 22 clear clear JJ cord-300311-eah49b3g 129 23 . . . cord-300311-eah49b3g 130 1 An an DT cord-300311-eah49b3g 130 2 oral oral JJ cord-300311-eah49b3g 130 3 corticosteroid corticosteroid NN cord-300311-eah49b3g 130 4 can can MD cord-300311-eah49b3g 130 5 be be VB cord-300311-eah49b3g 130 6 provided provide VBN cord-300311-eah49b3g 130 7 and and CC cord-300311-eah49b3g 130 8 kept keep VBN cord-300311-eah49b3g 130 9 on on IN cord-300311-eah49b3g 130 10 hand hand NN cord-300311-eah49b3g 130 11 by by IN cord-300311-eah49b3g 130 12 the the DT cord-300311-eah49b3g 130 13 patient patient NN cord-300311-eah49b3g 130 14 . . . cord-300311-eah49b3g 131 1 This this DT cord-300311-eah49b3g 131 2 permits permit VBZ cord-300311-eah49b3g 131 3 initiation initiation NN cord-300311-eah49b3g 131 4 of of IN cord-300311-eah49b3g 131 5 more more JJR cord-300311-eah49b3g 131 6 prompt prompt JJ cord-300311-eah49b3g 131 7 and and CC cord-300311-eah49b3g 131 8 effective effective JJ cord-300311-eah49b3g 131 9 treatment treatment NN cord-300311-eah49b3g 131 10 than than IN cord-300311-eah49b3g 131 11 is be VBZ cord-300311-eah49b3g 131 12 likely likely JJ cord-300311-eah49b3g 131 13 to to TO cord-300311-eah49b3g 131 14 occur occur VB cord-300311-eah49b3g 131 15 when when WRB cord-300311-eah49b3g 131 16 a a DT cord-300311-eah49b3g 131 17 patient patient NN cord-300311-eah49b3g 131 18 must must MD cord-300311-eah49b3g 131 19 first first RB cord-300311-eah49b3g 131 20 go go VB cord-300311-eah49b3g 131 21 to to IN cord-300311-eah49b3g 131 22 a a DT cord-300311-eah49b3g 131 23 physician physician NN cord-300311-eah49b3g 131 24 's 's POS cord-300311-eah49b3g 131 25 office office NN cord-300311-eah49b3g 131 26 or or CC cord-300311-eah49b3g 131 27 emergency emergency NN cord-300311-eah49b3g 131 28 department department NN cord-300311-eah49b3g 131 29 , , , cord-300311-eah49b3g 131 30 because because IN cord-300311-eah49b3g 131 31 it -PRON- PRP cord-300311-eah49b3g 131 32 can can MD cord-300311-eah49b3g 131 33 be be VB cord-300311-eah49b3g 131 34 taken take VBN cord-300311-eah49b3g 131 35 as as RB cord-300311-eah49b3g 131 36 soon soon RB cord-300311-eah49b3g 131 37 as as IN cord-300311-eah49b3g 131 38 the the DT cord-300311-eah49b3g 131 39 response response NN cord-300311-eah49b3g 131 40 to to IN cord-300311-eah49b3g 131 41 bronchodilator bronchodilator NN cord-300311-eah49b3g 131 42 therapy therapy NN cord-300311-eah49b3g 131 43 is be VBZ cord-300311-eah49b3g 131 44 incomplete incomplete JJ cord-300311-eah49b3g 131 45 [ [ -LRB- cord-300311-eah49b3g 131 46 21 21 CD cord-300311-eah49b3g 131 47 ] ] -RRB- cord-300311-eah49b3g 131 48 . . . cord-300311-eah49b3g 132 1 Moreover moreover RB cord-300311-eah49b3g 132 2 , , , cord-300311-eah49b3g 132 3 patients patient NNS cord-300311-eah49b3g 132 4 with with IN cord-300311-eah49b3g 132 5 asthma asthma NN cord-300311-eah49b3g 132 6 should should MD cord-300311-eah49b3g 132 7 be be VB cord-300311-eah49b3g 132 8 treated treat VBN cord-300311-eah49b3g 132 9 according accord VBG cord-300311-eah49b3g 132 10 to to IN cord-300311-eah49b3g 132 11 national national JJ cord-300311-eah49b3g 132 12 and and CC cord-300311-eah49b3g 132 13 international international JJ cord-300311-eah49b3g 132 14 standards standard NNS cord-300311-eah49b3g 132 15 . . . cord-300311-eah49b3g 133 1 Access access NN cord-300311-eah49b3g 133 2 to to IN cord-300311-eah49b3g 133 3 and and CC cord-300311-eah49b3g 133 4 compliance compliance NN cord-300311-eah49b3g 133 5 with with IN cord-300311-eah49b3g 133 6 inhaled inhale VBN cord-300311-eah49b3g 133 7 corticosteroid corticosteroid NN cord-300311-eah49b3g 133 8 treatment treatment NN cord-300311-eah49b3g 133 9 is be VBZ cord-300311-eah49b3g 133 10 an an DT cord-300311-eah49b3g 133 11 important important JJ cord-300311-eah49b3g 133 12 predictor predictor NN cord-300311-eah49b3g 133 13 of of IN cord-300311-eah49b3g 133 14 the the DT cord-300311-eah49b3g 133 15 likelihood likelihood NN cord-300311-eah49b3g 133 16 of of IN cord-300311-eah49b3g 133 17 asthma asthma NN cord-300311-eah49b3g 133 18 exacerbations exacerbation NNS cord-300311-eah49b3g 133 19 occurring occur VBG cord-300311-eah49b3g 133 20 , , , cord-300311-eah49b3g 133 21 including include VBG cord-300311-eah49b3g 133 22 those those DT cord-300311-eah49b3g 133 23 that that WDT cord-300311-eah49b3g 133 24 occur occur VBP cord-300311-eah49b3g 133 25 during during IN cord-300311-eah49b3g 133 26 respiratory respiratory JJ cord-300311-eah49b3g 133 27 viral viral JJ cord-300311-eah49b3g 133 28 infections infection NNS cord-300311-eah49b3g 133 29 [ [ -LRB- cord-300311-eah49b3g 133 30 2• 2• CD cord-300311-eah49b3g 133 31 ] ] -RRB- cord-300311-eah49b3g 133 32 . . . cord-300311-eah49b3g 134 1 Papers paper NNS cord-300311-eah49b3g 134 2 of of IN cord-300311-eah49b3g 134 3 particular particular JJ cord-300311-eah49b3g 134 4 interest interest NN cord-300311-eah49b3g 134 5 , , , cord-300311-eah49b3g 134 6 published publish VBN cord-300311-eah49b3g 134 7 recently recently RB cord-300311-eah49b3g 134 8 , , , cord-300311-eah49b3g 134 9 have have VBP cord-300311-eah49b3g 134 10 been be VBN cord-300311-eah49b3g 134 11 highlighted highlight VBN cord-300311-eah49b3g 134 12 as as IN cord-300311-eah49b3g 134 13 : : : cord-300311-eah49b3g 134 14 • • . cord-300311-eah49b3g 135 1 Of of IN cord-300311-eah49b3g 135 2 importance importance NN cord-300311-eah49b3g 135 3 •• •• CD cord-300311-eah49b3g 136 1 Of of IN cord-300311-eah49b3g 136 2 major major JJ cord-300311-eah49b3g 136 3 importance importance NN cord-300311-eah49b3g 136 4 Incidence incidence NN cord-300311-eah49b3g 136 5 and and CC cord-300311-eah49b3g 136 6 prevalence prevalence NN cord-300311-eah49b3g 136 7 of of IN cord-300311-eah49b3g 136 8 asthma asthma NN cord-300311-eah49b3g 136 9 and and CC cord-300311-eah49b3g 136 10 allergic allergic JJ cord-300311-eah49b3g 136 11 rhinitis rhinitis NN cord-300311-eah49b3g 136 12 : : : cord-300311-eah49b3g 136 13 a a DT cord-300311-eah49b3g 136 14 cohort cohort NN cord-300311-eah49b3g 136 15 study study NN cord-300311-eah49b3g 136 16 of of IN cord-300311-eah49b3g 136 17 Finnish finnish JJ cord-300311-eah49b3g 136 18 adolescents adolescent NNS cord-300311-eah49b3g 137 1 This this DT cord-300311-eah49b3g 137 2 review review NN cord-300311-eah49b3g 137 3 describes describe VBZ cord-300311-eah49b3g 137 4 the the DT cord-300311-eah49b3g 137 5 epidemiology epidemiology NN cord-300311-eah49b3g 137 6 of of IN cord-300311-eah49b3g 137 7 asthma asthma NN cord-300311-eah49b3g 137 8 exacerbations exacerbation NNS cord-300311-eah49b3g 137 9 based base VBN cord-300311-eah49b3g 137 10 on on IN cord-300311-eah49b3g 137 11 multiple multiple JJ cord-300311-eah49b3g 137 12 sources source NNS cord-300311-eah49b3g 137 13 Viruses virus NNS cord-300311-eah49b3g 137 14 as as IN cord-300311-eah49b3g 137 15 precipitants precipitant NNS cord-300311-eah49b3g 137 16 of of IN cord-300311-eah49b3g 137 17 asthmatic asthmatic JJ cord-300311-eah49b3g 137 18 attacks attack NNS cord-300311-eah49b3g 137 19 in in IN cord-300311-eah49b3g 137 20 children child NNS cord-300311-eah49b3g 137 21 Community Community NNP cord-300311-eah49b3g 137 22 study study NN cord-300311-eah49b3g 137 23 of of IN cord-300311-eah49b3g 137 24 role role NN cord-300311-eah49b3g 137 25 of of IN cord-300311-eah49b3g 137 26 viral viral JJ cord-300311-eah49b3g 137 27 infections infection NNS cord-300311-eah49b3g 137 28 in in IN cord-300311-eah49b3g 137 29 exacerbations exacerbation NNS cord-300311-eah49b3g 137 30 of of IN cord-300311-eah49b3g 137 31 asthma asthma NN cord-300311-eah49b3g 137 32 in in IN cord-300311-eah49b3g 137 33 9 9 CD cord-300311-eah49b3g 137 34 - - SYM cord-300311-eah49b3g 137 35 11 11 CD cord-300311-eah49b3g 137 36 year year NN cord-300311-eah49b3g 137 37 old old JJ cord-300311-eah49b3g 137 38 children child NNS cord-300311-eah49b3g 137 39 Asthma asthma VBP cord-300311-eah49b3g 137 40 exacerbations exacerbation NNS cord-300311-eah49b3g 137 41 in in IN cord-300311-eah49b3g 137 42 children child NNS cord-300311-eah49b3g 137 43 associated associate VBN cord-300311-eah49b3g 137 44 with with IN cord-300311-eah49b3g 137 45 rhinovirus rhinovirus NN cord-300311-eah49b3g 137 46 but but CC cord-300311-eah49b3g 137 47 not not RB cord-300311-eah49b3g 137 48 human human JJ cord-300311-eah49b3g 137 49 metapneumovirus metapneumovirus JJ cord-300311-eah49b3g 137 50 infection infection NN cord-300311-eah49b3g 137 51 Influenza Influenza NNP cord-300311-eah49b3g 137 52 vaccination vaccination NN cord-300311-eah49b3g 137 53 in in IN cord-300311-eah49b3g 137 54 asthmatic asthmatic JJ cord-300311-eah49b3g 137 55 children child NNS cord-300311-eah49b3g 137 56 : : : cord-300311-eah49b3g 137 57 effects effect NNS cord-300311-eah49b3g 137 58 on on IN cord-300311-eah49b3g 137 59 quality quality NN cord-300311-eah49b3g 137 60 of of IN cord-300311-eah49b3g 137 61 life life NN cord-300311-eah49b3g 137 62 and and CC cord-300311-eah49b3g 137 63 symptoms symptom NNS cord-300311-eah49b3g 137 64 Respiratory respiratory JJ cord-300311-eah49b3g 137 65 viruses virus NNS cord-300311-eah49b3g 137 66 and and CC cord-300311-eah49b3g 137 67 exacerbations exacerbation NNS cord-300311-eah49b3g 137 68 of of IN cord-300311-eah49b3g 137 69 asthma asthma NN cord-300311-eah49b3g 137 70 in in IN cord-300311-eah49b3g 137 71 adults adult NNS cord-300311-eah49b3g 137 72 Respiratory respiratory JJ cord-300311-eah49b3g 137 73 tract tract NN cord-300311-eah49b3g 137 74 viral viral JJ cord-300311-eah49b3g 137 75 infections infection NNS cord-300311-eah49b3g 137 76 in in IN cord-300311-eah49b3g 137 77 inner inner JJ cord-300311-eah49b3g 137 78 - - HYPH cord-300311-eah49b3g 137 79 city city NN cord-300311-eah49b3g 137 80 asthmatic asthmatic JJ cord-300311-eah49b3g 137 81 adults adult NNS cord-300311-eah49b3g 137 82 Viruses virus NNS cord-300311-eah49b3g 137 83 in in IN cord-300311-eah49b3g 137 84 asthma asthma NN cord-300311-eah49b3g 137 85 exacerbations exacerbation NNS cord-300311-eah49b3g 138 1 The the DT cord-300311-eah49b3g 138 2 relationship relationship NN cord-300311-eah49b3g 138 3 between between IN cord-300311-eah49b3g 138 4 upper upper JJ cord-300311-eah49b3g 138 5 respiratory respiratory JJ cord-300311-eah49b3g 138 6 infections infection NNS cord-300311-eah49b3g 138 7 and and CC cord-300311-eah49b3g 138 8 hospital hospital NN cord-300311-eah49b3g 138 9 admissions admission NNS cord-300311-eah49b3g 138 10 for for IN cord-300311-eah49b3g 138 11 asthma asthma NN cord-300311-eah49b3g 138 12 : : : cord-300311-eah49b3g 138 13 a a DT cord-300311-eah49b3g 138 14 time time NN cord-300311-eah49b3g 138 15 - - HYPH cord-300311-eah49b3g 138 16 trend trend NN cord-300311-eah49b3g 138 17 analysis analysis NN cord-300311-eah49b3g 138 18 Influenza influenza NN cord-300311-eah49b3g 138 19 and and CC cord-300311-eah49b3g 138 20 the the DT cord-300311-eah49b3g 138 21 rates rate NNS cord-300311-eah49b3g 138 22 of of IN cord-300311-eah49b3g 138 23 hospitalization hospitalization NN cord-300311-eah49b3g 138 24 for for IN cord-300311-eah49b3g 138 25 respiratory respiratory JJ cord-300311-eah49b3g 138 26 disease disease NN cord-300311-eah49b3g 138 27 among among IN cord-300311-eah49b3g 138 28 infants infant NNS cord-300311-eah49b3g 138 29 and and CC cord-300311-eah49b3g 138 30 young young JJ cord-300311-eah49b3g 138 31 children child NNS cord-300311-eah49b3g 139 1 The the DT cord-300311-eah49b3g 139 2 burden burden NN cord-300311-eah49b3g 139 3 of of IN cord-300311-eah49b3g 139 4 influenza influenza NN cord-300311-eah49b3g 139 5 illness illness NN cord-300311-eah49b3g 139 6 in in IN cord-300311-eah49b3g 139 7 children child NNS cord-300311-eah49b3g 139 8 with with IN cord-300311-eah49b3g 139 9 asthma asthma NN cord-300311-eah49b3g 139 10 and and CC cord-300311-eah49b3g 139 11 other other JJ cord-300311-eah49b3g 139 12 chronic chronic JJ cord-300311-eah49b3g 139 13 medical medical JJ cord-300311-eah49b3g 139 14 conditions condition NNS cord-300311-eah49b3g 139 15 Respiratory respiratory JJ cord-300311-eah49b3g 139 16 infections infection NNS cord-300311-eah49b3g 139 17 and and CC cord-300311-eah49b3g 139 18 the the DT cord-300311-eah49b3g 139 19 autumn autumn NN cord-300311-eah49b3g 139 20 increase increase NN cord-300311-eah49b3g 139 21 in in IN cord-300311-eah49b3g 139 22 asthma asthma NN cord-300311-eah49b3g 139 23 morbidity morbidity NN cord-300311-eah49b3g 140 1 The the DT cord-300311-eah49b3g 140 2 incidence incidence NN cord-300311-eah49b3g 140 3 of of IN cord-300311-eah49b3g 140 4 respiratory respiratory JJ cord-300311-eah49b3g 140 5 tract tract NN cord-300311-eah49b3g 140 6 infection infection NN cord-300311-eah49b3g 140 7 in in IN cord-300311-eah49b3g 140 8 adults adult NNS cord-300311-eah49b3g 140 9 requiring require VBG cord-300311-eah49b3g 140 10 hospitalization hospitalization NN cord-300311-eah49b3g 140 11 for for IN cord-300311-eah49b3g 140 12 asthma asthma NN cord-300311-eah49b3g 140 13 Spectrum Spectrum NNP cord-300311-eah49b3g 140 14 of of IN cord-300311-eah49b3g 140 15 clinical clinical JJ cord-300311-eah49b3g 140 16 illness illness NN cord-300311-eah49b3g 140 17 in in IN cord-300311-eah49b3g 140 18 hospitalized hospitalize VBN cord-300311-eah49b3g 140 19 patients patient NNS cord-300311-eah49b3g 140 20 with with IN cord-300311-eah49b3g 140 21 " " `` cord-300311-eah49b3g 140 22 common common JJ cord-300311-eah49b3g 140 23 cold cold JJ cord-300311-eah49b3g 140 24 " " '' cord-300311-eah49b3g 140 25 virus virus NN cord-300311-eah49b3g 140 26 infections infection NNS cord-300311-eah49b3g 140 27 Epidemiology epidemiology NN cord-300311-eah49b3g 140 28 of of IN cord-300311-eah49b3g 140 29 respiratory respiratory JJ cord-300311-eah49b3g 140 30 viruses virus NNS cord-300311-eah49b3g 140 31 in in IN cord-300311-eah49b3g 140 32 patients patient NNS cord-300311-eah49b3g 140 33 hospitalized hospitalize VBN cord-300311-eah49b3g 140 34 with with IN cord-300311-eah49b3g 140 35 near near RB cord-300311-eah49b3g 140 36 - - HYPH cord-300311-eah49b3g 140 37 fatal fatal JJ cord-300311-eah49b3g 140 38 asthma asthma NN cord-300311-eah49b3g 140 39 , , , cord-300311-eah49b3g 140 40 acute acute JJ cord-300311-eah49b3g 140 41 exacerbations exacerbation NNS cord-300311-eah49b3g 140 42 of of IN cord-300311-eah49b3g 140 43 asthma asthma NN cord-300311-eah49b3g 140 44 , , , cord-300311-eah49b3g 140 45 or or CC cord-300311-eah49b3g 140 46 chronic chronic JJ cord-300311-eah49b3g 140 47 obstructive obstructive JJ cord-300311-eah49b3g 140 48 pulmonary pulmonary JJ cord-300311-eah49b3g 140 49 disease disease NN cord-300311-eah49b3g 140 50 Population population NN cord-300311-eah49b3g 140 51 - - HYPH cord-300311-eah49b3g 140 52 based base VBN cord-300311-eah49b3g 140 53 surveillance surveillance NN cord-300311-eah49b3g 140 54 for for IN cord-300311-eah49b3g 140 55 hospitalizations hospitalization NNS cord-300311-eah49b3g 140 56 associated associate VBN cord-300311-eah49b3g 140 57 with with IN cord-300311-eah49b3g 140 58 respiratory respiratory JJ cord-300311-eah49b3g 140 59 syncytial syncytial JJ cord-300311-eah49b3g 140 60 virus virus NN cord-300311-eah49b3g 140 61 , , , cord-300311-eah49b3g 140 62 influenza influenza NN cord-300311-eah49b3g 140 63 virus virus NN cord-300311-eah49b3g 140 64 , , , cord-300311-eah49b3g 140 65 and and CC cord-300311-eah49b3g 140 66 parainfluenza parainfluenza NN cord-300311-eah49b3g 140 67 viruses virus NNS cord-300311-eah49b3g 140 68 among among IN cord-300311-eah49b3g 140 69 young young JJ cord-300311-eah49b3g 140 70 children child NNS cord-300311-eah49b3g 140 71 Inhaled inhale VBD cord-300311-eah49b3g 140 72 steroids steroid NNS cord-300311-eah49b3g 140 73 for for IN cord-300311-eah49b3g 140 74 episodic episodic JJ cord-300311-eah49b3g 140 75 viral viral JJ cord-300311-eah49b3g 140 76 wheeze wheeze NN cord-300311-eah49b3g 140 77 of of IN cord-300311-eah49b3g 140 78 childhood childhood NN cord-300311-eah49b3g 140 79 Early early JJ cord-300311-eah49b3g 140 80 use use NN cord-300311-eah49b3g 140 81 of of IN cord-300311-eah49b3g 140 82 inhaled inhale VBN cord-300311-eah49b3g 140 83 corticosteroids corticosteroid NNS cord-300311-eah49b3g 140 84 in in IN cord-300311-eah49b3g 140 85 the the DT cord-300311-eah49b3g 140 86 emergency emergency NN cord-300311-eah49b3g 140 87 department department NN cord-300311-eah49b3g 140 88 treatment treatment NN cord-300311-eah49b3g 140 89 of of IN cord-300311-eah49b3g 140 90 acute acute JJ cord-300311-eah49b3g 140 91 asthma asthma NN cord-300311-eah49b3g 140 92 Early early JJ cord-300311-eah49b3g 140 93 emergency emergency NN cord-300311-eah49b3g 140 94 department department NN cord-300311-eah49b3g 140 95 treatment treatment NN cord-300311-eah49b3g 140 96 of of IN cord-300311-eah49b3g 140 97 acute acute JJ cord-300311-eah49b3g 140 98 asthma asthma NN cord-300311-eah49b3g 140 99 with with IN cord-300311-eah49b3g 140 100 systemic systemic JJ cord-300311-eah49b3g 140 101 corticosteroids corticosteroid NNS cord-300311-eah49b3g 140 102 Treatment treatment NN cord-300311-eah49b3g 140 103 strategies strategy NNS cord-300311-eah49b3g 140 104 for for IN cord-300311-eah49b3g 140 105 viral viral JJ cord-300311-eah49b3g 140 106 respiratory respiratory JJ cord-300311-eah49b3g 140 107 infection infection NN cord-300311-eah49b3g 140 108 - - HYPH cord-300311-eah49b3g 140 109 induced induce VBN cord-300311-eah49b3g 140 110 asthma asthma NN cord-300311-eah49b3g 140 111 Epidemiology epidemiology NN cord-300311-eah49b3g 140 112 of of IN cord-300311-eah49b3g 140 113 human human JJ cord-300311-eah49b3g 140 114 rhinoviruses rhinovirus NNS cord-300311-eah49b3g 141 1 This this DT cord-300311-eah49b3g 141 2 interesting interesting JJ cord-300311-eah49b3g 141 3 thesis thesis NN cord-300311-eah49b3g 141 4 describes describe VBZ cord-300311-eah49b3g 141 5 the the DT cord-300311-eah49b3g 141 6 difficulties difficulty NNS cord-300311-eah49b3g 141 7 met meet VBN cord-300311-eah49b3g 141 8 and and CC cord-300311-eah49b3g 141 9 the the DT cord-300311-eah49b3g 141 10 progress progress NN cord-300311-eah49b3g 141 11 made make VBN cord-300311-eah49b3g 141 12 in in IN cord-300311-eah49b3g 141 13 rhinovirus rhinovirus NN cord-300311-eah49b3g 141 14 research research NN cord-300311-eah49b3g 141 15 Respiratory respiratory JJ cord-300311-eah49b3g 141 16 syncytial syncytial JJ cord-300311-eah49b3g 141 17 virus virus NN cord-300311-eah49b3g 141 18 infection infection NN cord-300311-eah49b3g 141 19 in in IN cord-300311-eah49b3g 141 20 elderly elderly JJ cord-300311-eah49b3g 141 21 and and CC cord-300311-eah49b3g 141 22 high high JJ cord-300311-eah49b3g 141 23 - - HYPH cord-300311-eah49b3g 141 24 risk risk NN cord-300311-eah49b3g 141 25 adults adult NNS cord-300311-eah49b3g 141 26 Clinical clinical JJ cord-300311-eah49b3g 141 27 patterns pattern NNS cord-300311-eah49b3g 141 28 and and CC cord-300311-eah49b3g 141 29 natural natural JJ cord-300311-eah49b3g 141 30 history history NN cord-300311-eah49b3g 141 31 of of IN cord-300311-eah49b3g 141 32 asthma asthma NN cord-300311-eah49b3g 141 33 Progress Progress NNP cord-300311-eah49b3g 141 34 in in IN cord-300311-eah49b3g 141 35 the the DT cord-300311-eah49b3g 141 36 development development NN cord-300311-eah49b3g 141 37 of of IN cord-300311-eah49b3g 141 38 respiratory respiratory JJ cord-300311-eah49b3g 141 39 syncytial syncytial JJ cord-300311-eah49b3g 141 40 virus virus NN cord-300311-eah49b3g 141 41 and and CC cord-300311-eah49b3g 141 42 parainfluenza parainfluenza NNP cord-300311-eah49b3g 141 43 virus virus NNP cord-300311-eah49b3g 141 44 vaccines vaccines NNPS cord-300311-eah49b3g 141 45 Influenza Influenza NNP cord-300311-eah49b3g 141 46 vaccination vaccination NN cord-300311-eah49b3g 141 47 in in IN cord-300311-eah49b3g 141 48 2000 2000 CD cord-300311-eah49b3g 141 49 : : : cord-300311-eah49b3g 141 50 recommendations recommendation NNS cord-300311-eah49b3g 141 51 and and CC cord-300311-eah49b3g 141 52 vaccine vaccine NN cord-300311-eah49b3g 141 53 use use NN cord-300311-eah49b3g 141 54 in in IN cord-300311-eah49b3g 141 55 50 50 CD cord-300311-eah49b3g 141 56 developed developed JJ cord-300311-eah49b3g 141 57 and and CC cord-300311-eah49b3g 141 58 rapidly rapidly RB cord-300311-eah49b3g 141 59 developing develop VBG cord-300311-eah49b3g 141 60 countries country NNS cord-300311-eah49b3g 141 61 Respiratory respiratory JJ cord-300311-eah49b3g 141 62 viral viral JJ cord-300311-eah49b3g 141 63 infections infection NNS cord-300311-eah49b3g 141 64 in in IN cord-300311-eah49b3g 141 65 adults adult NNS cord-300311-eah49b3g 141 66 WHO who WP cord-300311-eah49b3g 141 67 2003 2003 CD cord-300311-eah49b3g 141 68 : : : cord-300311-eah49b3g 142 1 Influenza Influenza NNP cord-300311-eah49b3g 142 2 Factsheet Factsheet NNP cord-300311-eah49b3g 142 3 Populationbased Populationbased NNP cord-300311-eah49b3g 142 4 study study NN cord-300311-eah49b3g 142 5 on on IN cord-300311-eah49b3g 142 6 incidence incidence NN cord-300311-eah49b3g 142 7 , , , cord-300311-eah49b3g 142 8 risk risk NN cord-300311-eah49b3g 142 9 factors factor NNS cord-300311-eah49b3g 142 10 , , , cord-300311-eah49b3g 142 11 clinical clinical JJ cord-300311-eah49b3g 142 12 complications complication NNS cord-300311-eah49b3g 142 13 and and CC cord-300311-eah49b3g 142 14 drug drug NN cord-300311-eah49b3g 142 15 utilisation utilisation NN cord-300311-eah49b3g 142 16 associated associate VBN cord-300311-eah49b3g 142 17 with with IN cord-300311-eah49b3g 142 18 influenza influenza NN cord-300311-eah49b3g 142 19 in in IN cord-300311-eah49b3g 142 20 the the DT cord-300311-eah49b3g 142 21 United United NNP cord-300311-eah49b3g 142 22 Kingdom Kingdom NNP cord-300311-eah49b3g 143 1 The the DT cord-300311-eah49b3g 143 2 underrecognized underrecognized JJ cord-300311-eah49b3g 143 3 burden burden NN cord-300311-eah49b3g 143 4 of of IN cord-300311-eah49b3g 143 5 influenza influenza NN cord-300311-eah49b3g 143 6 in in IN cord-300311-eah49b3g 143 7 young young JJ cord-300311-eah49b3g 143 8 children child NNS cord-300311-eah49b3g 144 1 The the DT cord-300311-eah49b3g 144 2 efficacy efficacy NN cord-300311-eah49b3g 144 3 of of IN cord-300311-eah49b3g 144 4 influenza influenza NN cord-300311-eah49b3g 144 5 vaccination vaccination NN cord-300311-eah49b3g 144 6 in in IN cord-300311-eah49b3g 144 7 elderly elderly JJ cord-300311-eah49b3g 144 8 individuals individual NNS cord-300311-eah49b3g 144 9 . . . cord-300311-eah49b3g 145 1 A a DT cord-300311-eah49b3g 145 2 randomized randomized JJ cord-300311-eah49b3g 145 3 double double JJ cord-300311-eah49b3g 145 4 - - HYPH cord-300311-eah49b3g 145 5 blind blind JJ cord-300311-eah49b3g 145 6 placebo placebo NN cord-300311-eah49b3g 145 7 - - HYPH cord-300311-eah49b3g 145 8 controlled control VBN cord-300311-eah49b3g 145 9 trial trial NN cord-300311-eah49b3g 145 10 Influenza Influenza NNP cord-300311-eah49b3g 145 11 vaccination vaccination NN cord-300311-eah49b3g 145 12 in in IN cord-300311-eah49b3g 145 13 children child NNS cord-300311-eah49b3g 145 14 with with IN cord-300311-eah49b3g 145 15 asthma asthma NN cord-300311-eah49b3g 145 16 : : : cord-300311-eah49b3g 145 17 randomized randomized JJ cord-300311-eah49b3g 145 18 double double JJ cord-300311-eah49b3g 145 19 - - HYPH cord-300311-eah49b3g 145 20 blind blind JJ cord-300311-eah49b3g 145 21 placebo placebo NN cord-300311-eah49b3g 145 22 - - HYPH cord-300311-eah49b3g 145 23 controlled control VBN cord-300311-eah49b3g 145 24 trial trial NN cord-300311-eah49b3g 145 25 Until until IN cord-300311-eah49b3g 145 26 now now RB cord-300311-eah49b3g 145 27 , , , cord-300311-eah49b3g 145 28 the the DT cord-300311-eah49b3g 145 29 only only JJ cord-300311-eah49b3g 145 30 RCT RCT NNP cord-300311-eah49b3g 145 31 investigating investigate VBG cord-300311-eah49b3g 145 32 the the DT cord-300311-eah49b3g 145 33 clinical clinical JJ cord-300311-eah49b3g 145 34 effectiveness effectiveness NN cord-300311-eah49b3g 145 35 of of IN cord-300311-eah49b3g 145 36 influenza influenza NN cord-300311-eah49b3g 145 37 vaccination vaccination NN cord-300311-eah49b3g 145 38 in in IN cord-300311-eah49b3g 145 39 children child NNS cord-300311-eah49b3g 145 40 Burden Burden NNP cord-300311-eah49b3g 145 41 of of IN cord-300311-eah49b3g 145 42 influenza influenza NN cord-300311-eah49b3g 145 43 in in IN cord-300311-eah49b3g 145 44 children child NNS cord-300311-eah49b3g 145 45 in in IN cord-300311-eah49b3g 145 46 the the DT cord-300311-eah49b3g 145 47 community community NN cord-300311-eah49b3g 145 48 Invited invite VBN cord-300311-eah49b3g 145 49 Commentary commentary NN cord-300311-eah49b3g 145 50 : : : cord-300311-eah49b3g 145 51 Use use NN cord-300311-eah49b3g 145 52 of of IN cord-300311-eah49b3g 145 53 selective selective JJ cord-300311-eah49b3g 145 54 viral viral JJ cord-300311-eah49b3g 145 55 cultures culture NNS cord-300311-eah49b3g 145 56 to to TO cord-300311-eah49b3g 145 57 adjust adjust VB cord-300311-eah49b3g 145 58 nonvirologic nonvirologic JJ cord-300311-eah49b3g 145 59 endpoints endpoint NNS cord-300311-eah49b3g 145 60 in in IN cord-300311-eah49b3g 145 61 studies study NNS cord-300311-eah49b3g 145 62 of of IN cord-300311-eah49b3g 145 63 influenza influenza NN cord-300311-eah49b3g 145 64 vaccine vaccine NN cord-300311-eah49b3g 145 65 efficacy efficacy NN cord-300311-eah49b3g 145 66 Incidence incidence NN cord-300311-eah49b3g 145 67 of of IN cord-300311-eah49b3g 145 68 influenza influenza NN cord-300311-eah49b3g 145 69 and and CC cord-300311-eah49b3g 145 70 associated associate VBD cord-300311-eah49b3g 145 71 illness illness NN cord-300311-eah49b3g 145 72 in in IN cord-300311-eah49b3g 145 73 children child NNS cord-300311-eah49b3g 145 74 aged age VBD cord-300311-eah49b3g 145 75 0 0 CD cord-300311-eah49b3g 145 76 - - SYM cord-300311-eah49b3g 145 77 19 19 CD cord-300311-eah49b3g 145 78 years year NNS cord-300311-eah49b3g 145 79 : : : cord-300311-eah49b3g 145 80 a a DT cord-300311-eah49b3g 145 81 systematic systematic JJ cord-300311-eah49b3g 145 82 review review NN cord-300311-eah49b3g 145 83 Vaccines vaccine NNS cord-300311-eah49b3g 145 84 for for IN cord-300311-eah49b3g 145 85 preventing prevent VBG cord-300311-eah49b3g 145 86 influenza influenza NN cord-300311-eah49b3g 145 87 in in IN cord-300311-eah49b3g 145 88 healthy healthy JJ cord-300311-eah49b3g 145 89 adults adult NNS cord-300311-eah49b3g 145 90 Assessment Assessment NNP cord-300311-eah49b3g 145 91 of of IN cord-300311-eah49b3g 145 92 the the DT cord-300311-eah49b3g 145 93 efficacy efficacy NN cord-300311-eah49b3g 145 94 and and CC cord-300311-eah49b3g 145 95 effectiveness effectiveness NN cord-300311-eah49b3g 145 96 of of IN cord-300311-eah49b3g 145 97 influenza influenza NN cord-300311-eah49b3g 145 98 vaccines vaccine NNS cord-300311-eah49b3g 145 99 in in IN cord-300311-eah49b3g 145 100 healthy healthy JJ cord-300311-eah49b3g 145 101 children child NNS cord-300311-eah49b3g 145 102 : : : cord-300311-eah49b3g 145 103 systematic systematic JJ cord-300311-eah49b3g 145 104 review review NN cord-300311-eah49b3g 145 105 Methodological methodological JJ cord-300311-eah49b3g 145 106 quality quality NN cord-300311-eah49b3g 145 107 of of IN cord-300311-eah49b3g 145 108 studies study NNS cord-300311-eah49b3g 145 109 and and CC cord-300311-eah49b3g 145 110 patient patient JJ cord-300311-eah49b3g 145 111 age age NN cord-300311-eah49b3g 145 112 as as IN cord-300311-eah49b3g 145 113 major major JJ cord-300311-eah49b3g 145 114 sources source NNS cord-300311-eah49b3g 145 115 of of IN cord-300311-eah49b3g 145 116 variation variation NN cord-300311-eah49b3g 145 117 in in IN cord-300311-eah49b3g 145 118 efficacy efficacy NN cord-300311-eah49b3g 145 119 estimates estimate NNS cord-300311-eah49b3g 145 120 of of IN cord-300311-eah49b3g 145 121 influenza influenza NN cord-300311-eah49b3g 145 122 vaccination vaccination NN cord-300311-eah49b3g 145 123 in in IN cord-300311-eah49b3g 145 124 healthy healthy JJ cord-300311-eah49b3g 145 125 adults adult NNS cord-300311-eah49b3g 145 126 : : : cord-300311-eah49b3g 145 127 a a DT cord-300311-eah49b3g 145 128 meta meta JJ cord-300311-eah49b3g 145 129 - - HYPH cord-300311-eah49b3g 145 130 analysis analysis NN cord-300311-eah49b3g 145 131 Clinical clinical JJ cord-300311-eah49b3g 145 132 effectiveness effectiveness NN cord-300311-eah49b3g 145 133 of of IN cord-300311-eah49b3g 145 134 conventional conventional JJ cord-300311-eah49b3g 145 135 influenza influenza NN cord-300311-eah49b3g 145 136 vaccination vaccination NN cord-300311-eah49b3g 145 137 in in IN cord-300311-eah49b3g 145 138 asthmatic asthmatic JJ cord-300311-eah49b3g 145 139 children child NNS cord-300311-eah49b3g 145 140 Effectiveness Effectiveness NNP cord-300311-eah49b3g 145 141 of of IN cord-300311-eah49b3g 145 142 influenza influenza JJ cord-300311-eah49b3g 145 143 vaccine vaccine NN cord-300311-eah49b3g 145 144 for for IN cord-300311-eah49b3g 145 145 the the DT cord-300311-eah49b3g 145 146 prevention prevention NN cord-300311-eah49b3g 145 147 of of IN cord-300311-eah49b3g 145 148 asthma asthma NN cord-300311-eah49b3g 145 149 exacerbations exacerbation NNS cord-300311-eah49b3g 145 150 Influenza Influenza NNP cord-300311-eah49b3g 145 151 vaccination vaccination NN cord-300311-eah49b3g 145 152 in in IN cord-300311-eah49b3g 145 153 patients patient NNS cord-300311-eah49b3g 145 154 with with IN cord-300311-eah49b3g 145 155 asthma asthma NN cord-300311-eah49b3g 145 156 : : : cord-300311-eah49b3g 145 157 effect effect VB cord-300311-eah49b3g 145 158 on on IN cord-300311-eah49b3g 145 159 the the DT cord-300311-eah49b3g 145 160 frequency frequency NN cord-300311-eah49b3g 145 161 of of IN cord-300311-eah49b3g 145 162 upper upper JJ cord-300311-eah49b3g 145 163 respiratory respiratory JJ cord-300311-eah49b3g 145 164 tract tract NN cord-300311-eah49b3g 145 165 infections infection NNS cord-300311-eah49b3g 145 166 and and CC cord-300311-eah49b3g 145 167 exacerbations exacerbation NNS cord-300311-eah49b3g 145 168 Vaccines vaccine NNS cord-300311-eah49b3g 145 169 for for IN cord-300311-eah49b3g 145 170 preventing prevent VBG cord-300311-eah49b3g 145 171 influenza influenza NN cord-300311-eah49b3g 145 172 in in IN cord-300311-eah49b3g 145 173 people people NNS cord-300311-eah49b3g 145 174 with with IN cord-300311-eah49b3g 145 175 asthma asthma NN cord-300311-eah49b3g 145 176 . . . cord-300311-eah49b3g 146 1 Cochrane Cochrane NNP cord-300311-eah49b3g 146 2 Database Database NNP cord-300311-eah49b3g 146 3 Syst Syst NNP cord-300311-eah49b3g 146 4 Rev Rev NNP cord-300311-eah49b3g 146 5 2004 2004 CD cord-300311-eah49b3g 146 6 : : : cord-300311-eah49b3g 146 7 CD000364 CD000364 NNP cord-300311-eah49b3g 146 8 . . . cord-300311-eah49b3g 147 1 Systematic systematic JJ cord-300311-eah49b3g 147 2 review review NN cord-300311-eah49b3g 147 3 gathering gathering NN cord-300311-eah49b3g 147 4 all all DT cord-300311-eah49b3g 147 5 available available JJ cord-300311-eah49b3g 147 6 evidence evidence NN cord-300311-eah49b3g 147 7 from from IN cord-300311-eah49b3g 147 8 randomized randomized JJ cord-300311-eah49b3g 147 9 controlled control VBN cord-300311-eah49b3g 147 10 trials trial NNS cord-300311-eah49b3g 147 11 into into IN cord-300311-eah49b3g 147 12 the the DT cord-300311-eah49b3g 147 13 effects effect NNS cord-300311-eah49b3g 147 14 and and CC cord-300311-eah49b3g 147 15 adverse adverse JJ cord-300311-eah49b3g 147 16 events event NNS cord-300311-eah49b3g 147 17 of of IN cord-300311-eah49b3g 147 18 influenza influenza NN cord-300311-eah49b3g 147 19 vaccination vaccination NN cord-300311-eah49b3g 148 1 The the DT cord-300311-eah49b3g 148 2 cost cost NN cord-300311-eah49b3g 148 3 - - HYPH cord-300311-eah49b3g 148 4 effectiveness effectiveness NN cord-300311-eah49b3g 148 5 of of IN cord-300311-eah49b3g 148 6 a a DT cord-300311-eah49b3g 148 7 hypothetical hypothetical JJ cord-300311-eah49b3g 148 8 respiratory respiratory JJ cord-300311-eah49b3g 148 9 syncytial syncytial JJ cord-300311-eah49b3g 148 10 virus virus NN cord-300311-eah49b3g 148 11 vaccine vaccine NN cord-300311-eah49b3g 148 12 in in IN cord-300311-eah49b3g 148 13 the the DT cord-300311-eah49b3g 148 14 elderly elderly JJ cord-300311-eah49b3g 148 15 Systematic systematic JJ cord-300311-eah49b3g 148 16 review review NN cord-300311-eah49b3g 148 17 and and CC cord-300311-eah49b3g 148 18 economic economic JJ cord-300311-eah49b3g 148 19 decision decision NN cord-300311-eah49b3g 148 20 modelling modelling NN cord-300311-eah49b3g 148 21 for for IN cord-300311-eah49b3g 148 22 the the DT cord-300311-eah49b3g 148 23 prevention prevention NN cord-300311-eah49b3g 148 24 and and CC cord-300311-eah49b3g 148 25 treatment treatment NN cord-300311-eah49b3g 148 26 of of IN cord-300311-eah49b3g 148 27 influenza influenza NN cord-300311-eah49b3g 148 28 A a NN cord-300311-eah49b3g 148 29 and and CC cord-300311-eah49b3g 148 30 B b NN cord-300311-eah49b3g 148 31 Influence influence NN cord-300311-eah49b3g 148 32 of of IN cord-300311-eah49b3g 148 33 clinical clinical JJ cord-300311-eah49b3g 148 34 outcome outcome NN cord-300311-eah49b3g 148 35 and and CC cord-300311-eah49b3g 148 36 outcome outcome NN cord-300311-eah49b3g 148 37 period period NN cord-300311-eah49b3g 148 38 definitions definition NNS cord-300311-eah49b3g 148 39 on on IN cord-300311-eah49b3g 148 40 estimates estimate NNS cord-300311-eah49b3g 148 41 of of IN cord-300311-eah49b3g 148 42 absolute absolute JJ cord-300311-eah49b3g 148 43 clinical clinical JJ cord-300311-eah49b3g 148 44 and and CC cord-300311-eah49b3g 148 45 economic economic JJ cord-300311-eah49b3g 148 46 benefits benefit NNS cord-300311-eah49b3g 148 47 of of IN cord-300311-eah49b3g 148 48 influenza influenza NN cord-300311-eah49b3g 148 49 vaccination vaccination NN cord-300311-eah49b3g 148 50 in in IN cord-300311-eah49b3g 148 51 community community NN cord-300311-eah49b3g 148 52 dwelling dwell VBG cord-300311-eah49b3g 148 53 elderly elderly JJ cord-300311-eah49b3g 148 54 persons person NNS cord-300311-eah49b3g 148 55 Prevention Prevention NNP cord-300311-eah49b3g 148 56 and and CC cord-300311-eah49b3g 148 57 early early JJ cord-300311-eah49b3g 148 58 treatment treatment NN cord-300311-eah49b3g 148 59 of of IN cord-300311-eah49b3g 148 60 influenza influenza NN cord-300311-eah49b3g 148 61 in in IN cord-300311-eah49b3g 148 62 healthy healthy JJ cord-300311-eah49b3g 148 63 adults adult NNS cord-300311-eah49b3g 148 64 Is be VBZ cord-300311-eah49b3g 148 65 immunizing immunize VBG cord-300311-eah49b3g 148 66 all all DT cord-300311-eah49b3g 148 67 patients patient NNS cord-300311-eah49b3g 148 68 with with IN cord-300311-eah49b3g 148 69 chronic chronic JJ cord-300311-eah49b3g 148 70 lung lung NN cord-300311-eah49b3g 148 71 disease disease NN cord-300311-eah49b3g 148 72 in in IN cord-300311-eah49b3g 148 73 the the DT cord-300311-eah49b3g 148 74 community community NN cord-300311-eah49b3g 148 75 against against IN cord-300311-eah49b3g 148 76 influenza influenza NN cord-300311-eah49b3g 148 77 cost cost NN cord-300311-eah49b3g 148 78 effective effective JJ cord-300311-eah49b3g 148 79 ? ? . cord-300311-eah49b3g 149 1 Evidence evidence NN cord-300311-eah49b3g 149 2 from from IN cord-300311-eah49b3g 149 3 a a DT cord-300311-eah49b3g 149 4 general general JJ cord-300311-eah49b3g 149 5 practice practice NN cord-300311-eah49b3g 149 6 based base VBN cord-300311-eah49b3g 149 7 clinical clinical JJ cord-300311-eah49b3g 149 8 prospective prospective JJ cord-300311-eah49b3g 149 9 cohort cohort NN cord-300311-eah49b3g 149 10 study study NN cord-300311-eah49b3g 149 11 in in IN cord-300311-eah49b3g 149 12 Utrecht Utrecht NNP cord-300311-eah49b3g 149 13 , , , cord-300311-eah49b3g 149 14 The the DT cord-300311-eah49b3g 149 15 Netherlands Netherlands NNP cord-300311-eah49b3g 149 16 Cost cost NN cord-300311-eah49b3g 149 17 - - HYPH cord-300311-eah49b3g 149 18 effectiveness effectiveness NN cord-300311-eah49b3g 149 19 of of IN cord-300311-eah49b3g 149 20 influenza influenza NN cord-300311-eah49b3g 149 21 vaccination vaccination NN cord-300311-eah49b3g 149 22 in in IN cord-300311-eah49b3g 149 23 high high JJ cord-300311-eah49b3g 149 24 - - HYPH cord-300311-eah49b3g 149 25 risk risk NN cord-300311-eah49b3g 149 26 children child NNS cord-300311-eah49b3g 149 27 in in IN cord-300311-eah49b3g 149 28 Argentina Argentina NNP