id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255725-7l9lk9x2	Hertzog, Paul J	Sculpting the immune response to infection	2011-06-20		.txt	text/plain	3537	142	34	This report describes advances in the understanding of how microbes elicit and evade immune responses and the sensing of pathogens by host cells that leads to the activation and production of intraand extracellular signaling molecules. C. Roy (New Haven, Connecticut, USA) presented work on Legionella pneumophila, the causative agent of Legionnaire's disease, demonstrating that this opportunistic and accidental intracellular pathogen stimulates almost every pathway of the innate immune response as it infects and subsequently replicates in macrophages 7 . Beard (Adelaide, Australia), who has used transcriptome analysis of liver infected with hepatitis C virus (HCV) to show that the interferon-stimulated gene product viperin and members of the interferon-inducible transmembrane family of proteins have distinct anti-HCV properties and act via inhibition of viral replication and entry, respectively, which thereby raises new possibilities for targeting chronic HCV infection. The signal-transduction programs of core cells of the innate immune response, such as macrophages, are mediated by key transcription factors such as the IRF proteins.	./cache/cord-255725-7l9lk9x2.txt	./txt/cord-255725-7l9lk9x2.txt