id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010819-a0nbmx3l	Stettler, Gregory R.	Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients	2020-03-10		.txt	text/plain	4468	234	46	CONCLUSION: In the injured patient, high blood alcohol levels are associated with increased incidence of fibrinolysis shutdown. Further research is needed to assess whether the association with fibrinolysis is modified by the chronicity and type of alcohol consumed and whether anti-fibrinolytic therapy in intoxicated patients produces adverse effects. Fibrinolysis shutdown has previously been identified as the most common fibrinolytic phenotype following injury and is also associated with increased mortality compared to physiologic fibrinolysis, often due to multiple organ failure [15] [16] [17] and has most commonly been measured by thrombelastography (TEG), a viscoelastic assay that provides a comprehensive assessment of clot formation and clot remodeling and degradation. In vitro and in vivo studies have provided data that ethanol affects the fibrinolysis profile and studies in healthy human volunteers suggest that this decrease in fibrinolysis is secondary to Patients with a high BAL class had an increased incidence of fibrinolysis compared to those with no detectable blood alcohol and those with > 0-150 mg/ dL (0-1.5 g/L) circulating levels of PAI-1 [2, 26] .	./cache/cord-010819-a0nbmx3l.txt	./txt/cord-010819-a0nbmx3l.txt