id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005882-iodfgzjf	Kaufmann, Stefan H E	Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis	2005-04-05		.txt	text/plain	9665	515	42	Elucidation of the genetic mechanisms underlying susceptibility and protective immune mechanisms in resistant individuals that prevent disease outbreak in face of ongoing infection, as well as identification of the pathogen genes that promote transformation of latent infection into active tuberculosis, will facilitate rational design of a postexposure vaccine 27, 28, 31 . Generally, subunit vaccines crucially depend on appropriate adjuvants 38 that stimulate T helper type 1 (T H 1) immune responses by the different T cell populations required for protection against tuberculosis. Despite previous reluctance, a recent expert group meeting has strongly advocated development of viable recombinant vaccines against tuberculosis because they are the most potent stimulators of protective immune responses that perform better than BCG in experimental animal models 60 . In humans, therapeutic vaccination would probably be used to stimulate T cell responses in HIV-infected people whose virus was well controlled by antiretroviral drugs, with the aim of terminating antiretroviral therapy (ART) once the T cell levels were boosted.	./cache/cord-005882-iodfgzjf.txt	./txt/cord-005882-iodfgzjf.txt