id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289742-1usxeo9a	Riksen, Niels P.	Immunometabolic control of trained immunity	2020-09-02		.txt	text/plain	7653	333	31	Indeed, in murine models, stimuli that induce trained immunity in circulating monocytes, including Western type diet feeding, BCG vaccination, or administration of β-glucan, were found to trigger a persistent inflammatory reprogramming of myeloid progenitor cells in the bone marrow (Christ et al., 2018; Mitroulis et al., 2018) . Finally, additional proof for a role of glycolysis in trained immunity stems from the observations that in cohorts of healthy subjects, single nucleotide polymorphisms (SNPs) in key glycolytic enzymes are associated with the induction of cytokine production capacity by training of the cells ex vivo; this was reported for SNPs in hexokinase 2 (HK2) and phosphofructokinase, platelet (PFKP) for training with BCG . When innate immune cells, such as monocytes, are stimulated by growth signals or inflammatory stimuli, e.g. lipopolysaccharide, the TCA cycle shifts function to provide intermediary metabolites for biosynthetic pathways, including the production of amino acids and lipids, which is termed cataplerosis.	./cache/cord-289742-1usxeo9a.txt	./txt/cord-289742-1usxeo9a.txt