id author title date pages extension mime words sentences flesch summary cache txt cord-315101-7mim3yl6 Kumar Gupta, Pramod New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19? 2020-07-28 .txt text/plain 1233 95 34 Recent reports have suggested that BCG vaccination might have protective effects against COVID-19, however it is highly unlikely that BCG vaccine in its current form can offer complete protection against SARS-CoV-2 infection due to the lack of specific immunity. Nonetheless, recombinant BCG strains expressing antigens of SARS-CoV-2 may offer protection against COVID-19 due to the activation of innate as well as specific adaptive immune response. In this review we discuss about the heterologous effects of BCG, induction of trained immunity and its implication in development of a potential vaccine against COVID-19 pandemic. BCG Vaccination Protects against Experimental Viral Infection in Humans through 370 the Induction of Cytokines Associated with Trained Immunity BCG-Induced Cross-Protection and Development of Trained 376 Immunity: Implication for Vaccine Design BCG-induced trained immunity in NK cells: Role for non-specific protection to 416 infection Long-Lasting Effects of 483 BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity ./cache/cord-315101-7mim3yl6.txt ./txt/cord-315101-7mim3yl6.txt