id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280480-djv7pc3m	Jägers, Johannes	Perfluorocarbon-based oxygen carriers: from physics to physiology	2020-11-03		.txt	text/plain	6217	342	47	Extensive research created stable PFC nano-emulsions that avoid (i) fast clearance from the blood and (ii) long organ retention time, which leads to undesired transient side effects. By linking the unique properties of PFCs and PFOCs to physiology, it elaborates on the response, processing and dysregulation, which the body experiences through intravascular PFOCs. Thereby the reader will receive a scientific and easily comprehensible overview why PFOCs are precious tools for so many diverse application areas from cancer therapeutics to blood substitutes up to organ preservation and diving disease. This emulsification paved the way to using PFCs as oxygen carriers in physiological systems by developing a way to allow the addition of, e.g., water-soluble nutrients and pharmaceuticals. Even though these first-generation PFC-based oxygen carriers (PFOCs) showed major physiological side effects, the main reason for stopping the clinical trials in the 1990s was the insufficient shelf life [36, 51, 101] .	./cache/cord-280480-djv7pc3m.txt	./txt/cord-280480-djv7pc3m.txt