id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318598-pzlf2zpc	Roberts, Brian K.	Basic Shock Physiology and Critical Care	2016-04-28		.txt	text/plain	4995	327	44	This article discusses the pathophysiology of shock and the systemic inflammatory response syndrome, which may lead to organ dysfunction, organ failure, sepsis, and death. If perfusion, effective circulating volume, cardiac output, and/or oxygen delivery do not improve from compensatory mechanisms, additional symptoms of prolonged capillary refill, poor pulse quality, and hypotension occur. When there is significant hypovolemia, trauma, or sepsis with resultant sympathetic-induced vasoconstriction, the splanchnic vasculature is affected, 50 leading to ischemic injury and loss of the protective gastrointestinal barrier, which is primarily sustained because of normal capillary mucosal blood flow. [56] [57] [58] In rats, typical increases in heart rate Basic Shock Physiology and Critical Care and sympathetic response occur during sepsis and shock, characterized by tachycardia and decreased mean arterial pressure. 62 One study of rabbits that underwent experimental hemorrhagic shock by removing 26% of blood volume noted tachycardia, hypotension, and significantly decreased cardiac output versus controls.	./cache/cord-318598-pzlf2zpc.txt	./txt/cord-318598-pzlf2zpc.txt