id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011669-hkkpw2bl	Rodríguez-Sánchez, Diego Noé	Lissencephaly in Shih Tzu dogs	2020-06-20		.txt	text/plain	4842	289	41	Here, we characterize the first cases of lissencephaly in four Shih Tzu dogs, including clinical presentations and findings of magnetic resonance imaging of lissencephaly and several concomitant brain malformations. CASE PRESENTATION: Early-onset acute signs of forebrain abnormalities were observed in all dogs, which were mainly cluster seizures and behavioral alterations. CONCLUSIONS: Lissencephaly should be considered an important differential diagnosis in Shih Tzu dogs presenting with early-onset signs of forebrain abnormalities, including cluster seizures and behavioral alterations. Clinical findings and magnetic resonance imaging (MRI) features of lissencephaly in Shih Tzu dogs have not been reported previously, and reports of concomitant brain malformations are scarce. Magnetic resonance imaging in dogs with lissencephaly showed thickened cortical gray matter with smooth appearance, an abnormally small internal capsule, and absence of the major gyri and sulci when compared with healthy Shih Tzu dogs (Additional file 2).	./cache/cord-011669-hkkpw2bl.txt	./txt/cord-011669-hkkpw2bl.txt