id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264266-6xvj9zey	Chakrabarti, Sankha Shubhra	COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?	2020-05-09		.txt	text/plain	3845	175	46	Apart from SARS-CoV and MERS-CoV which caused severe respiratory diseases following outbreaks in 2003 and 2012, there are four endemic human corona viruses, HCoV-229E, HCoV NL-63, HCoV-OC4, HCoV-HKU1 in populations that are responsible for various types of respiratory illness which are generally self-limiting in young and immunecompetent persons [8] . It can be assumed that some degrees of sequence homology or conformational similarities among the structural proteins, especially the S protein, of SARS-CoV-2 and the endemic corona viruses (HCoV-229E, HCoV NL-63, HCoV-OC4, HCoV-HKU1) may result in cross-reactive immunity (circulating antibodies or primed T-cells) in persons with prior exposure to the latter viruses, and this may modulate the course and outcome of COVID-19. Thus, the possibility of a protective cross-immunity in the Indian population against COVID-19 cannot be ignored in explaining a rather mild effect of the current coronavirus pandemic in India in comparison to that in Europe and the USA. Therefore, cross-reactive antibodies generated as a result of infections from other human corona viruses may have a protective role in a population affected by COVID-19.	./cache/cord-264266-6xvj9zey.txt	./txt/cord-264266-6xvj9zey.txt