id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319805-b6ypt5d0	Siepmann, Timo	Association of history of cerebrovascular disease with severity of COVID-19	2020-08-06		.txt	text/plain	5096	230	40	We systematically searched electronic databases including MEDLINE (accessed by PubMed), EMBASE and Cochrane Library for identification of all available observational studies that reported on laboratory-confirmed COVID-19 patients aged ≥18 years with information given on disease severity and past history of CVD. Multivariable logistic regression was performed to explore the predictive value of history of CVD for severity outcomes of COVID-19 including clinical severity according to the classification by the National Health Commission guidelines on the Diagnosis and Treatment of COVID-19, in-hospital death and necessity of intensive care [10]. When considering only published data from Chinese cohorts in pooled analysis (n = 1805), history of CVD was also associated with increased risk of severity of COVID-19 (RR 2.39, 95% CI 1.94-2.94; p < 0.0001) with similar results on sensitivity analyses for study-specific severity outcomes (clinical parameters: RR 1.83, 95% CI 1.28-2.63; p = 0.001; necessity of intensive care: RR 2.9, 95% CI 1.61-5.24; p < 0.0001 and in-hospital death: RR 2.14, 95% CI 1.7-2.7; p < 0.0001).	./cache/cord-319805-b6ypt5d0.txt	./txt/cord-319805-b6ypt5d0.txt