id sid tid token lemma pos cord-283202-5fq1wxz8 1 1 key key JJ cord-283202-5fq1wxz8 1 2 : : : cord-283202-5fq1wxz8 1 3 cord-283202 cord-283202 NNP cord-283202-5fq1wxz8 2 1 -5fq1wxz8 -5fq1wxz8 NNP cord-283202-5fq1wxz8 2 2 authors author NNS cord-283202-5fq1wxz8 2 3 : : : cord-283202-5fq1wxz8 2 4 Kent Kent NNP cord-283202-5fq1wxz8 2 5 , , , cord-283202-5fq1wxz8 2 6 Marc Marc NNP cord-283202-5fq1wxz8 2 7 title title NN cord-283202-5fq1wxz8 2 8 : : : cord-283202-5fq1wxz8 2 9 The the DT cord-283202-5fq1wxz8 2 10 cat cat NN cord-283202-5fq1wxz8 2 11 with with IN cord-283202-5fq1wxz8 2 12 neurological neurological JJ cord-283202-5fq1wxz8 2 13 manifestations manifestation NNS cord-283202-5fq1wxz8 2 14 of of IN cord-283202-5fq1wxz8 2 15 systemic systemic JJ cord-283202-5fq1wxz8 2 16 disease disease NN cord-283202-5fq1wxz8 2 17 . . . cord-283202-5fq1wxz8 3 1 Key key JJ cord-283202-5fq1wxz8 3 2 conditions condition NNS cord-283202-5fq1wxz8 3 3 impacting impact VBG cord-283202-5fq1wxz8 3 4 on on IN cord-283202-5fq1wxz8 3 5 the the DT cord-283202-5fq1wxz8 3 6 CNS CNS NNP cord-283202-5fq1wxz8 3 7 date date NN cord-283202-5fq1wxz8 3 8 : : : cord-283202-5fq1wxz8 3 9 2009 2009 CD cord-283202-5fq1wxz8 3 10 - - SYM cord-283202-5fq1wxz8 3 11 05 05 CD cord-283202-5fq1wxz8 3 12 - - HYPH cord-283202-5fq1wxz8 3 13 31 31 CD cord-283202-5fq1wxz8 3 14 journal journal NN cord-283202-5fq1wxz8 3 15 : : : cord-283202-5fq1wxz8 3 16 Journal Journal NNP cord-283202-5fq1wxz8 3 17 of of IN cord-283202-5fq1wxz8 3 18 Feline Feline NNP cord-283202-5fq1wxz8 3 19 Medicine Medicine NNP cord-283202-5fq1wxz8 3 20 & & CC cord-283202-5fq1wxz8 3 21 Surgery Surgery NNP cord-283202-5fq1wxz8 4 1 DOI DOI NNP cord-283202-5fq1wxz8 4 2 : : : cord-283202-5fq1wxz8 5 1 10.1016 10.1016 CD cord-283202-5fq1wxz8 5 2 / / SYM cord-283202-5fq1wxz8 5 3 j.jfms.2009.03.007 j.jfms.2009.03.007 NNP cord-283202-5fq1wxz8 5 4 sha sha NNP cord-283202-5fq1wxz8 5 5 : : : cord-283202-5fq1wxz8 5 6 c427cddf32dd09a3d25936ad03e439498532703e c427cddf32dd09a3d25936ad03e439498532703e NNP cord-283202-5fq1wxz8 5 7 doc_id doc_id NNP cord-283202-5fq1wxz8 5 8 : : : cord-283202-5fq1wxz8 6 1 283202 283202 CD cord-283202-5fq1wxz8 6 2 cord_uid cord_uid NNS cord-283202-5fq1wxz8 6 3 : : : cord-283202-5fq1wxz8 6 4 5fq1wxz8 5fq1wxz8 LS cord-283202-5fq1wxz8 6 5 Practical practical JJ cord-283202-5fq1wxz8 6 6 relevance relevance NN cord-283202-5fq1wxz8 7 1 A a DT cord-283202-5fq1wxz8 7 2 number number NN cord-283202-5fq1wxz8 7 3 of of IN cord-283202-5fq1wxz8 7 4 systemic systemic JJ cord-283202-5fq1wxz8 7 5 diseases disease NNS cord-283202-5fq1wxz8 7 6 are be VBP cord-283202-5fq1wxz8 7 7 associated associate VBN cord-283202-5fq1wxz8 7 8 with with IN cord-283202-5fq1wxz8 7 9 neurological neurological JJ cord-283202-5fq1wxz8 7 10 deficits deficit NNS cord-283202-5fq1wxz8 7 11 . . . cord-283202-5fq1wxz8 8 1 Most Most JJS cord-283202-5fq1wxz8 8 2 systemic systemic JJ cord-283202-5fq1wxz8 8 3 diseases disease NNS cord-283202-5fq1wxz8 8 4 that that WDT cord-283202-5fq1wxz8 8 5 impact impact VBP cord-283202-5fq1wxz8 8 6 on on IN cord-283202-5fq1wxz8 8 7 the the DT cord-283202-5fq1wxz8 8 8 nervous nervous JJ cord-283202-5fq1wxz8 8 9 system system NN cord-283202-5fq1wxz8 8 10 result result VBP cord-283202-5fq1wxz8 8 11 in in IN cord-283202-5fq1wxz8 8 12 multifocal multifocal JJ cord-283202-5fq1wxz8 8 13 neurological neurological JJ cord-283202-5fq1wxz8 8 14 signs sign NNS cord-283202-5fq1wxz8 8 15 ; ; : cord-283202-5fq1wxz8 8 16 however however RB cord-283202-5fq1wxz8 8 17 , , , cord-283202-5fq1wxz8 8 18 isolated isolated JJ cord-283202-5fq1wxz8 8 19 deficits deficit NNS cord-283202-5fq1wxz8 8 20 can can MD cord-283202-5fq1wxz8 8 21 also also RB cord-283202-5fq1wxz8 8 22 be be VB cord-283202-5fq1wxz8 8 23 observed observe VBN cord-283202-5fq1wxz8 8 24 . . . cord-283202-5fq1wxz8 9 1 This this DT cord-283202-5fq1wxz8 9 2 article article NN cord-283202-5fq1wxz8 9 3 reviews review VBZ cord-283202-5fq1wxz8 9 4 the the DT cord-283202-5fq1wxz8 9 5 clinical clinical JJ cord-283202-5fq1wxz8 9 6 signs sign NNS cord-283202-5fq1wxz8 9 7 , , , cord-283202-5fq1wxz8 9 8 pathophysiology pathophysiology NN cord-283202-5fq1wxz8 9 9 , , , cord-283202-5fq1wxz8 9 10 diagnosis diagnosis NN cord-283202-5fq1wxz8 9 11 , , , cord-283202-5fq1wxz8 9 12 treatment treatment NN cord-283202-5fq1wxz8 9 13 and and CC cord-283202-5fq1wxz8 9 14 prognosis prognosis NN cord-283202-5fq1wxz8 9 15 of of IN cord-283202-5fq1wxz8 9 16 four four CD cord-283202-5fq1wxz8 9 17 important important JJ cord-283202-5fq1wxz8 9 18 systemic systemic JJ cord-283202-5fq1wxz8 9 19 diseases disease NNS cord-283202-5fq1wxz8 9 20 with with IN cord-283202-5fq1wxz8 9 21 neurological neurological JJ cord-283202-5fq1wxz8 9 22 consequences consequence NNS cord-283202-5fq1wxz8 9 23 : : : cord-283202-5fq1wxz8 9 24 feline feline JJ cord-283202-5fq1wxz8 9 25 infectious infectious JJ cord-283202-5fq1wxz8 9 26 peritonitis peritonitis NN cord-283202-5fq1wxz8 9 27 , , , cord-283202-5fq1wxz8 9 28 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 9 29 , , , cord-283202-5fq1wxz8 9 30 hypertension hypertension NN cord-283202-5fq1wxz8 9 31 and and CC cord-283202-5fq1wxz8 9 32 hepatic hepatic JJ cord-283202-5fq1wxz8 9 33 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 9 34 . . . cord-283202-5fq1wxz8 10 1 Clinical clinical JJ cord-283202-5fq1wxz8 10 2 challenges challenge NNS cord-283202-5fq1wxz8 11 1 Early early JJ cord-283202-5fq1wxz8 11 2 recognition recognition NN cord-283202-5fq1wxz8 11 3 of of IN cord-283202-5fq1wxz8 11 4 systemic systemic JJ cord-283202-5fq1wxz8 11 5 signs sign NNS cord-283202-5fq1wxz8 11 6 of of IN cord-283202-5fq1wxz8 11 7 illness illness NN cord-283202-5fq1wxz8 11 8 in in IN cord-283202-5fq1wxz8 11 9 conjunction conjunction NN cord-283202-5fq1wxz8 11 10 with with IN cord-283202-5fq1wxz8 11 11 neurological neurological JJ cord-283202-5fq1wxz8 11 12 deficits deficit NNS cord-283202-5fq1wxz8 11 13 will will MD cord-283202-5fq1wxz8 11 14 allow allow VB cord-283202-5fq1wxz8 11 15 for for IN cord-283202-5fq1wxz8 11 16 prompt prompt JJ cord-283202-5fq1wxz8 11 17 diagnosis diagnosis NN cord-283202-5fq1wxz8 11 18 and and CC cord-283202-5fq1wxz8 11 19 treatment treatment NN cord-283202-5fq1wxz8 11 20 . . . cord-283202-5fq1wxz8 12 1 While while IN cord-283202-5fq1wxz8 12 2 neurological neurological JJ cord-283202-5fq1wxz8 12 3 examination examination NN cord-283202-5fq1wxz8 12 4 of of IN cord-283202-5fq1wxz8 12 5 the the DT cord-283202-5fq1wxz8 12 6 feline feline JJ cord-283202-5fq1wxz8 12 7 patient patient NN cord-283202-5fq1wxz8 12 8 can can MD cord-283202-5fq1wxz8 12 9 undoubtedly undoubtedly RB cord-283202-5fq1wxz8 12 10 be be VB cord-283202-5fq1wxz8 12 11 challenging challenging JJ cord-283202-5fq1wxz8 12 12 , , , cord-283202-5fq1wxz8 12 13 hopefully hopefully RB cord-283202-5fq1wxz8 12 14 the the DT cord-283202-5fq1wxz8 12 15 accompanying accompany VBG cord-283202-5fq1wxz8 12 16 articles article NNS cord-283202-5fq1wxz8 12 17 in in IN cord-283202-5fq1wxz8 12 18 this this DT cord-283202-5fq1wxz8 12 19 special special JJ cord-283202-5fq1wxz8 12 20 issue issue NN cord-283202-5fq1wxz8 12 21 will will MD cord-283202-5fq1wxz8 12 22 enable enable VB cord-283202-5fq1wxz8 12 23 the the DT cord-283202-5fq1wxz8 12 24 clinician clinician NN cord-283202-5fq1wxz8 12 25 to to TO cord-283202-5fq1wxz8 12 26 approach approach VB cord-283202-5fq1wxz8 12 27 these these DT cord-283202-5fq1wxz8 12 28 cases case NNS cord-283202-5fq1wxz8 12 29 with with IN cord-283202-5fq1wxz8 12 30 more more JJR cord-283202-5fq1wxz8 12 31 confidence confidence NN cord-283202-5fq1wxz8 12 32 . . . cord-283202-5fq1wxz8 13 1 Evidence evidence NN cord-283202-5fq1wxz8 13 2 base base NN cord-283202-5fq1wxz8 14 1 The the DT cord-283202-5fq1wxz8 14 2 veterinary veterinary JJ cord-283202-5fq1wxz8 14 3 literature literature NN cord-283202-5fq1wxz8 14 4 contains contain VBZ cord-283202-5fq1wxz8 14 5 numerous numerous JJ cord-283202-5fq1wxz8 14 6 reports report NNS cord-283202-5fq1wxz8 14 7 detailing detail VBG cord-283202-5fq1wxz8 14 8 the the DT cord-283202-5fq1wxz8 14 9 impact impact NN cord-283202-5fq1wxz8 14 10 of of IN cord-283202-5fq1wxz8 14 11 systemic systemic JJ cord-283202-5fq1wxz8 14 12 disease disease NN cord-283202-5fq1wxz8 14 13 on on IN cord-283202-5fq1wxz8 14 14 the the DT cord-283202-5fq1wxz8 14 15 nervous nervous JJ cord-283202-5fq1wxz8 14 16 system system NN cord-283202-5fq1wxz8 14 17 . . . cord-283202-5fq1wxz8 15 1 Unfortunately unfortunately RB cord-283202-5fq1wxz8 15 2 , , , cord-283202-5fq1wxz8 15 3 very very RB cord-283202-5fq1wxz8 15 4 few few JJ cord-283202-5fq1wxz8 15 5 references reference NNS cord-283202-5fq1wxz8 15 6 provide provide VBP cord-283202-5fq1wxz8 15 7 detailed detailed JJ cord-283202-5fq1wxz8 15 8 descriptions description NNS cord-283202-5fq1wxz8 15 9 of of IN cord-283202-5fq1wxz8 15 10 large large JJ cord-283202-5fq1wxz8 15 11 cohorts cohort NNS cord-283202-5fq1wxz8 15 12 of of IN cord-283202-5fq1wxz8 15 13 affected affected JJ cord-283202-5fq1wxz8 15 14 cats cat NNS cord-283202-5fq1wxz8 15 15 . . . cord-283202-5fq1wxz8 16 1 This this DT cord-283202-5fq1wxz8 16 2 review review NN cord-283202-5fq1wxz8 16 3 summarises summarise VBZ cord-283202-5fq1wxz8 16 4 the the DT cord-283202-5fq1wxz8 16 5 literature literature NN cord-283202-5fq1wxz8 16 6 underpinning underpin VBG cord-283202-5fq1wxz8 16 7 the the DT cord-283202-5fq1wxz8 16 8 four four CD cord-283202-5fq1wxz8 16 9 key key JJ cord-283202-5fq1wxz8 16 10 diseases disease NNS cord-283202-5fq1wxz8 16 11 under under IN cord-283202-5fq1wxz8 16 12 discussion discussion NN cord-283202-5fq1wxz8 16 13 . . . cord-283202-5fq1wxz8 17 1 Knowledge knowledge NN cord-283202-5fq1wxz8 17 2 of of IN cord-283202-5fq1wxz8 17 3 the the DT cord-283202-5fq1wxz8 17 4 epidemiology epidemiology NN cord-283202-5fq1wxz8 17 5 of of IN cord-283202-5fq1wxz8 17 6 FCoV FCoV NNP cord-283202-5fq1wxz8 17 7 infection infection NN cord-283202-5fq1wxz8 17 8 is be VBZ cord-283202-5fq1wxz8 17 9 important important JJ cord-283202-5fq1wxz8 17 10 in in IN cord-283202-5fq1wxz8 17 11 order order NN cord-283202-5fq1wxz8 17 12 to to TO cord-283202-5fq1wxz8 17 13 understand understand VB cord-283202-5fq1wxz8 17 14 the the DT cord-283202-5fq1wxz8 17 15 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 17 16 of of IN cord-283202-5fq1wxz8 17 17 FIPV FIPV NNS cord-283202-5fq1wxz8 17 18 . . . cord-283202-5fq1wxz8 18 1 Feline feline JJ cord-283202-5fq1wxz8 18 2 coronavirus coronavirus NN cord-283202-5fq1wxz8 18 3 infection infection NN cord-283202-5fq1wxz8 18 4 is be VBZ cord-283202-5fq1wxz8 18 5 virtually virtually RB cord-283202-5fq1wxz8 18 6 endemic endemic JJ cord-283202-5fq1wxz8 18 7 , , , cord-283202-5fq1wxz8 18 8 with with IN cord-283202-5fq1wxz8 18 9 studies study NNS cord-283202-5fq1wxz8 18 10 revealing reveal VBG cord-283202-5fq1wxz8 18 11 that that IN cord-283202-5fq1wxz8 18 12 : : : cord-283202-5fq1wxz8 18 13 ✜ ✜ NN cord-283202-5fq1wxz8 18 14 Approximately approximately RB cord-283202-5fq1wxz8 18 15 50 50 CD cord-283202-5fq1wxz8 18 16 % % NN cord-283202-5fq1wxz8 18 17 of of IN cord-283202-5fq1wxz8 18 18 cats cat NNS cord-283202-5fq1wxz8 18 19 in in IN cord-283202-5fq1wxz8 18 20 the the DT cord-283202-5fq1wxz8 18 21 United United NNP cord-283202-5fq1wxz8 18 22 States States NNP cord-283202-5fq1wxz8 18 23 and and CC cord-283202-5fq1wxz8 18 24 Europe Europe NNP cord-283202-5fq1wxz8 18 25 have have VBP cord-283202-5fq1wxz8 18 26 antibodies antibody NNS cord-283202-5fq1wxz8 18 27 against against IN cord-283202-5fq1wxz8 18 28 FCoV FCoV NNP cord-283202-5fq1wxz8 18 29 ; ; : cord-283202-5fq1wxz8 18 30 3 3 CD cord-283202-5fq1wxz8 18 31 ✜ ✜ NN cord-283202-5fq1wxz8 18 32 In in IN cord-283202-5fq1wxz8 18 33 Australia Australia NNP cord-283202-5fq1wxz8 18 34 , , , cord-283202-5fq1wxz8 18 35 the the DT cord-283202-5fq1wxz8 18 36 seroprevalence seroprevalence NN cord-283202-5fq1wxz8 18 37 in in IN cord-283202-5fq1wxz8 18 38 owned own VBN cord-283202-5fq1wxz8 18 39 cats cat NNS cord-283202-5fq1wxz8 18 40 is be VBZ cord-283202-5fq1wxz8 18 41 approximately approximately RB cord-283202-5fq1wxz8 18 42 34 34 CD cord-283202-5fq1wxz8 18 43 % % NN cord-283202-5fq1wxz8 18 44 ; ; : cord-283202-5fq1wxz8 18 45 7 7 CD cord-283202-5fq1wxz8 18 46 ✜ ✜ NN cord-283202-5fq1wxz8 18 47 In in IN cord-283202-5fq1wxz8 18 48 the the DT cord-283202-5fq1wxz8 18 49 UK UK NNP cord-283202-5fq1wxz8 18 50 , , , cord-283202-5fq1wxz8 19 1 82 82 CD cord-283202-5fq1wxz8 19 2 % % NN cord-283202-5fq1wxz8 19 3 of of IN cord-283202-5fq1wxz8 19 4 show show NN cord-283202-5fq1wxz8 19 5 cats cat NNS cord-283202-5fq1wxz8 19 6 , , , cord-283202-5fq1wxz8 19 7 53 53 CD cord-283202-5fq1wxz8 19 8 % % NN cord-283202-5fq1wxz8 19 9 of of IN cord-283202-5fq1wxz8 19 10 breeding breed VBG cord-283202-5fq1wxz8 19 11 cats cat NNS cord-283202-5fq1wxz8 19 12 and and CC cord-283202-5fq1wxz8 19 13 15 15 CD cord-283202-5fq1wxz8 19 14 % % NN cord-283202-5fq1wxz8 19 15 of of IN cord-283202-5fq1wxz8 19 16 single single JJ cord-283202-5fq1wxz8 19 17 - - HYPH cord-283202-5fq1wxz8 19 18 cat cat NN cord-283202-5fq1wxz8 19 19 homes home NNS cord-283202-5fq1wxz8 19 20 have have VBP cord-283202-5fq1wxz8 19 21 anti anti JJ cord-283202-5fq1wxz8 19 22 - - JJ cord-283202-5fq1wxz8 19 23 FCoV fcov JJ cord-283202-5fq1wxz8 19 24 antibodies antibody NNS cord-283202-5fq1wxz8 19 25 ; ; : cord-283202-5fq1wxz8 19 26 8 8 CD cord-283202-5fq1wxz8 19 27 ✜ ✜ NN cord-283202-5fq1wxz8 19 28 In in IN cord-283202-5fq1wxz8 19 29 Italy Italy NNP cord-283202-5fq1wxz8 19 30 , , , cord-283202-5fq1wxz8 19 31 the the DT cord-283202-5fq1wxz8 19 32 seroprevalence seroprevalence NN cord-283202-5fq1wxz8 19 33 is be VBZ cord-283202-5fq1wxz8 19 34 82 82 CD cord-283202-5fq1wxz8 19 35 % % NN cord-283202-5fq1wxz8 19 36 in in IN cord-283202-5fq1wxz8 19 37 cats cat NNS cord-283202-5fq1wxz8 19 38 from from IN cord-283202-5fq1wxz8 19 39 breeding breed VBG cord-283202-5fq1wxz8 19 40 colonies colony NNS cord-283202-5fq1wxz8 19 41 , , , cord-283202-5fq1wxz8 19 42 shelters shelter NNS cord-283202-5fq1wxz8 19 43 and and CC cord-283202-5fq1wxz8 19 44 homes home NNS cord-283202-5fq1wxz8 19 45 ; ; : cord-283202-5fq1wxz8 19 46 9 9 CD cord-283202-5fq1wxz8 19 47 ✜ ✜ NN cord-283202-5fq1wxz8 19 48 In in IN cord-283202-5fq1wxz8 19 49 Switzerland Switzerland NNP cord-283202-5fq1wxz8 19 50 , , , cord-283202-5fq1wxz8 19 51 similarly similarly RB cord-283202-5fq1wxz8 19 52 80 80 CD cord-283202-5fq1wxz8 19 53 % % NN cord-283202-5fq1wxz8 19 54 of of IN cord-283202-5fq1wxz8 19 55 breeding breed VBG cord-283202-5fq1wxz8 19 56 cats cat NNS cord-283202-5fq1wxz8 19 57 , , , cord-283202-5fq1wxz8 19 58 and and CC cord-283202-5fq1wxz8 19 59 50 50 CD cord-283202-5fq1wxz8 19 60 % % NN cord-283202-5fq1wxz8 19 61 of of IN cord-283202-5fq1wxz8 19 62 free free RB cord-283202-5fq1wxz8 19 63 - - HYPH cord-283202-5fq1wxz8 19 64 roaming roam VBG cord-283202-5fq1wxz8 19 65 cats cat NNS cord-283202-5fq1wxz8 19 66 , , , cord-283202-5fq1wxz8 19 67 test test VBP cord-283202-5fq1wxz8 19 68 positive positive JJ cord-283202-5fq1wxz8 19 69 for for IN cord-283202-5fq1wxz8 19 70 anti anti JJ cord-283202-5fq1wxz8 19 71 - - JJ cord-283202-5fq1wxz8 19 72 FCoV fcov JJ cord-283202-5fq1wxz8 19 73 antibodies antibody NNS cord-283202-5fq1wxz8 19 74 . . . cord-283202-5fq1wxz8 20 1 10 10 CD cord-283202-5fq1wxz8 21 1 The the DT cord-283202-5fq1wxz8 21 2 significance significance NN cord-283202-5fq1wxz8 21 3 of of IN cord-283202-5fq1wxz8 21 4 this this DT cord-283202-5fq1wxz8 21 5 worldwide worldwide JJ cord-283202-5fq1wxz8 21 6 distribution distribution NN cord-283202-5fq1wxz8 21 7 relates relate VBZ cord-283202-5fq1wxz8 21 8 to to IN cord-283202-5fq1wxz8 21 9 the the DT cord-283202-5fq1wxz8 21 10 fact fact NN cord-283202-5fq1wxz8 21 11 that that IN cord-283202-5fq1wxz8 21 12 FIPV FIPV NNP cord-283202-5fq1wxz8 21 13 is be VBZ cord-283202-5fq1wxz8 21 14 the the DT cord-283202-5fq1wxz8 21 15 result result NN cord-283202-5fq1wxz8 21 16 of of IN cord-283202-5fq1wxz8 21 17 spontaneous spontaneous JJ cord-283202-5fq1wxz8 21 18 mutation mutation NN cord-283202-5fq1wxz8 21 19 of of IN cord-283202-5fq1wxz8 21 20 FECV FECV NNP cord-283202-5fq1wxz8 21 21 , , , cord-283202-5fq1wxz8 21 22 which which WDT cord-283202-5fq1wxz8 21 23 means mean VBZ cord-283202-5fq1wxz8 21 24 that that IN cord-283202-5fq1wxz8 21 25 cats cat NNS cord-283202-5fq1wxz8 21 26 worldwide worldwide RB cord-283202-5fq1wxz8 21 27 are be VBP cord-283202-5fq1wxz8 21 28 susceptible susceptible JJ cord-283202-5fq1wxz8 21 29 to to IN cord-283202-5fq1wxz8 21 30 developing develop VBG cord-283202-5fq1wxz8 21 31 FIP FIP NNP cord-283202-5fq1wxz8 21 32 . . . cord-283202-5fq1wxz8 22 1 6 6 CD cord-283202-5fq1wxz8 23 1 Despite despite IN cord-283202-5fq1wxz8 23 2 this this DT cord-283202-5fq1wxz8 23 3 , , , cord-283202-5fq1wxz8 23 4 approximately approximately RB cord-283202-5fq1wxz8 23 5 5 5 CD cord-283202-5fq1wxz8 23 6 % % NN cord-283202-5fq1wxz8 23 7 of of IN cord-283202-5fq1wxz8 23 8 cats cat NNS cord-283202-5fq1wxz8 23 9 in in IN cord-283202-5fq1wxz8 23 10 multicat multicat JJ cord-283202-5fq1wxz8 23 11 homes home NNS cord-283202-5fq1wxz8 23 12 and and CC cord-283202-5fq1wxz8 23 13 a a DT cord-283202-5fq1wxz8 23 14 smaller small JJR cord-283202-5fq1wxz8 23 15 percentage percentage NN cord-283202-5fq1wxz8 23 16 of of IN cord-283202-5fq1wxz8 23 17 cats cat NNS cord-283202-5fq1wxz8 23 18 in in IN cord-283202-5fq1wxz8 23 19 single single JJ cord-283202-5fq1wxz8 23 20 - - HYPH cord-283202-5fq1wxz8 23 21 cat cat NN cord-283202-5fq1wxz8 23 22 homes home NNS cord-283202-5fq1wxz8 23 23 develop develop VBP cord-283202-5fq1wxz8 23 24 FIP FIP NNP cord-283202-5fq1wxz8 23 25 . . . cord-283202-5fq1wxz8 24 1 3 3 CD cord-283202-5fq1wxz8 24 2 , , , cord-283202-5fq1wxz8 24 3 11 11 CD cord-283202-5fq1wxz8 24 4 , , , cord-283202-5fq1wxz8 24 5 12 12 CD cord-283202-5fq1wxz8 24 6 Notably notably RB cord-283202-5fq1wxz8 24 7 , , , cord-283202-5fq1wxz8 24 8 it -PRON- PRP cord-283202-5fq1wxz8 24 9 is be VBZ cord-283202-5fq1wxz8 24 10 young young JJ cord-283202-5fq1wxz8 24 11 cats cat NNS cord-283202-5fq1wxz8 24 12 and and CC cord-283202-5fq1wxz8 24 13 immunosuppressed immunosuppressed JJ cord-283202-5fq1wxz8 24 14 cats cat NNS cord-283202-5fq1wxz8 24 15 that that WDT cord-283202-5fq1wxz8 24 16 are be VBP cord-283202-5fq1wxz8 24 17 most most RBS cord-283202-5fq1wxz8 24 18 susceptible susceptible JJ cord-283202-5fq1wxz8 24 19 to to IN cord-283202-5fq1wxz8 24 20 developing develop VBG cord-283202-5fq1wxz8 24 21 FIP FIP NNP cord-283202-5fq1wxz8 24 22 . . . cord-283202-5fq1wxz8 25 1 In in IN cord-283202-5fq1wxz8 25 2 addition addition NN cord-283202-5fq1wxz8 25 3 , , , cord-283202-5fq1wxz8 25 4 certain certain JJ cord-283202-5fq1wxz8 25 5 purebreed purebreed JJ cord-283202-5fq1wxz8 25 6 cats cat NNS cord-283202-5fq1wxz8 25 7 , , , cord-283202-5fq1wxz8 25 8 specifically specifically RB cord-283202-5fq1wxz8 25 9 the the DT cord-283202-5fq1wxz8 25 10 Birman Birman NNP cord-283202-5fq1wxz8 25 11 , , , cord-283202-5fq1wxz8 25 12 Ragdoll Ragdoll NNP cord-283202-5fq1wxz8 25 13 , , , cord-283202-5fq1wxz8 25 14 Bengal Bengal NNP cord-283202-5fq1wxz8 25 15 , , , cord-283202-5fq1wxz8 25 16 Rex Rex NNP cord-283202-5fq1wxz8 25 17 , , , cord-283202-5fq1wxz8 25 18 Abyssinian abyssinian JJ cord-283202-5fq1wxz8 25 19 and and CC cord-283202-5fq1wxz8 25 20 Himalayan himalayan JJ cord-283202-5fq1wxz8 25 21 breeds breed NNS cord-283202-5fq1wxz8 25 22 , , , cord-283202-5fq1wxz8 25 23 have have VBP cord-283202-5fq1wxz8 25 24 a a DT cord-283202-5fq1wxz8 25 25 greater great JJR cord-283202-5fq1wxz8 25 26 risk risk NN cord-283202-5fq1wxz8 25 27 of of IN cord-283202-5fq1wxz8 25 28 developing develop VBG cord-283202-5fq1wxz8 25 29 FIP FIP NNP cord-283202-5fq1wxz8 25 30 , , , cord-283202-5fq1wxz8 25 31 which which WDT cord-283202-5fq1wxz8 25 32 suggests suggest VBZ cord-283202-5fq1wxz8 25 33 a a DT cord-283202-5fq1wxz8 25 34 genetic genetic JJ cord-283202-5fq1wxz8 25 35 influence influence NN cord-283202-5fq1wxz8 25 36 on on IN cord-283202-5fq1wxz8 25 37 susceptibility susceptibility NN cord-283202-5fq1wxz8 25 38 . . . cord-283202-5fq1wxz8 26 1 13 13 CD cord-283202-5fq1wxz8 26 2 Transmission Transmission NNP cord-283202-5fq1wxz8 26 3 of of IN cord-283202-5fq1wxz8 26 4 FCoV FCoV NNP cord-283202-5fq1wxz8 26 5 is be VBZ cord-283202-5fq1wxz8 26 6 through through IN cord-283202-5fq1wxz8 26 7 infected infect VBN cord-283202-5fq1wxz8 26 8 fecal fecal JJ cord-283202-5fq1wxz8 26 9 material material NN cord-283202-5fq1wxz8 26 10 via via IN cord-283202-5fq1wxz8 26 11 the the DT cord-283202-5fq1wxz8 26 12 orofecal orofecal JJ cord-283202-5fq1wxz8 26 13 route route NN cord-283202-5fq1wxz8 26 14 , , , cord-283202-5fq1wxz8 26 15 leading lead VBG cord-283202-5fq1wxz8 26 16 to to IN cord-283202-5fq1wxz8 26 17 enteric enteric JJ cord-283202-5fq1wxz8 26 18 infection infection NN cord-283202-5fq1wxz8 26 19 . . . cord-283202-5fq1wxz8 27 1 Enteric enteric JJ cord-283202-5fq1wxz8 27 2 FCoV FCoV NNP cord-283202-5fq1wxz8 27 3 infection infection NN cord-283202-5fq1wxz8 27 4 typically typically RB cord-283202-5fq1wxz8 27 5 results result VBZ cord-283202-5fq1wxz8 27 6 in in IN cord-283202-5fq1wxz8 27 7 inappetence inappetence NN cord-283202-5fq1wxz8 27 8 and/or and/or CC cord-283202-5fq1wxz8 27 9 mild mild JJ cord-283202-5fq1wxz8 27 10 gastrointestinal gastrointestinal JJ cord-283202-5fq1wxz8 27 11 signs sign NNS cord-283202-5fq1wxz8 27 12 such such JJ cord-283202-5fq1wxz8 27 13 as as IN cord-283202-5fq1wxz8 27 14 vomiting vomiting NN cord-283202-5fq1wxz8 27 15 and and CC cord-283202-5fq1wxz8 27 16 diarrhea diarrhea NN cord-283202-5fq1wxz8 27 17 . . . cord-283202-5fq1wxz8 28 1 Infected infected JJ cord-283202-5fq1wxz8 28 2 cats cat NNS cord-283202-5fq1wxz8 28 3 shed shed VBD cord-283202-5fq1wxz8 28 4 FECV FECV NNP cord-283202-5fq1wxz8 28 5 for for IN cord-283202-5fq1wxz8 28 6 up up IN cord-283202-5fq1wxz8 28 7 to to TO cord-283202-5fq1wxz8 28 8 10 10 CD cord-283202-5fq1wxz8 28 9 months month NNS cord-283202-5fq1wxz8 28 10 post post NN cord-283202-5fq1wxz8 28 11 infection infection NN cord-283202-5fq1wxz8 28 12 ; ; : cord-283202-5fq1wxz8 28 13 thereafter thereafter IN cord-283202-5fq1wxz8 28 14 infected infect VBN cord-283202-5fq1wxz8 28 15 cats cat NNS cord-283202-5fq1wxz8 28 16 shed shed VBP cord-283202-5fq1wxz8 28 17 virus virus NN cord-283202-5fq1wxz8 28 18 intermittently intermittently RB cord-283202-5fq1wxz8 28 19 or or CC cord-283202-5fq1wxz8 28 20 continuously continuously RB cord-283202-5fq1wxz8 28 21 , , , cord-283202-5fq1wxz8 28 22 serving serve VBG cord-283202-5fq1wxz8 28 23 as as IN cord-283202-5fq1wxz8 28 24 chronic chronic JJ cord-283202-5fq1wxz8 28 25 carriers carrier NNS cord-283202-5fq1wxz8 28 26 and and CC cord-283202-5fq1wxz8 28 27 thereby thereby RB cord-283202-5fq1wxz8 28 28 perpetuating perpetuate VBG cord-283202-5fq1wxz8 28 29 reinfection reinfection NN cord-283202-5fq1wxz8 28 30 of of IN cord-283202-5fq1wxz8 28 31 other other JJ cord-283202-5fq1wxz8 28 32 individuals individual NNS cord-283202-5fq1wxz8 28 33 . . . cord-283202-5fq1wxz8 29 1 14 14 CD cord-283202-5fq1wxz8 30 1 As as IN cord-283202-5fq1wxz8 30 2 with with IN cord-283202-5fq1wxz8 30 3 all all DT cord-283202-5fq1wxz8 30 4 coronaviruses coronaviruse NNS cord-283202-5fq1wxz8 30 5 , , , cord-283202-5fq1wxz8 30 6 FECV FECV NNP cord-283202-5fq1wxz8 30 7 undergoes undergo VBZ cord-283202-5fq1wxz8 30 8 a a DT cord-283202-5fq1wxz8 30 9 high high JJ cord-283202-5fq1wxz8 30 10 rate rate NN cord-283202-5fq1wxz8 30 11 of of IN cord-283202-5fq1wxz8 30 12 mutation mutation NN cord-283202-5fq1wxz8 30 13 . . . cord-283202-5fq1wxz8 31 1 The the DT cord-283202-5fq1wxz8 31 2 degree degree NN cord-283202-5fq1wxz8 31 3 of of IN cord-283202-5fq1wxz8 31 4 mutation mutation NN cord-283202-5fq1wxz8 31 5 , , , cord-283202-5fq1wxz8 31 6 and and CC cord-283202-5fq1wxz8 31 7 therefore therefore RB cord-283202-5fq1wxz8 31 8 the the DT cord-283202-5fq1wxz8 31 9 development development NN cord-283202-5fq1wxz8 31 10 of of IN cord-283202-5fq1wxz8 31 11 a a DT cord-283202-5fq1wxz8 31 12 mutation mutation NN cord-283202-5fq1wxz8 31 13 leading lead VBG cord-283202-5fq1wxz8 31 14 to to IN cord-283202-5fq1wxz8 31 15 FIP FIP NNP cord-283202-5fq1wxz8 31 16 , , , cord-283202-5fq1wxz8 31 17 appear appear VBP cord-283202-5fq1wxz8 31 18 greater great JJR cord-283202-5fq1wxz8 31 19 in in IN cord-283202-5fq1wxz8 31 20 susceptible susceptible JJ cord-283202-5fq1wxz8 31 21 individuals individual NNS cord-283202-5fq1wxz8 31 22 as as RB cord-283202-5fq1wxz8 31 23 well well RB cord-283202-5fq1wxz8 31 24 as as IN cord-283202-5fq1wxz8 31 25 in in IN cord-283202-5fq1wxz8 31 26 individuals individual NNS cord-283202-5fq1wxz8 31 27 with with IN cord-283202-5fq1wxz8 31 28 a a DT cord-283202-5fq1wxz8 31 29 high high JJ cord-283202-5fq1wxz8 31 30 viral viral JJ cord-283202-5fq1wxz8 31 31 load load NN cord-283202-5fq1wxz8 31 32 . . . cord-283202-5fq1wxz8 32 1 15 15 CD cord-283202-5fq1wxz8 32 2 , , , cord-283202-5fq1wxz8 32 3 16 16 CD cord-283202-5fq1wxz8 33 1 In in IN cord-283202-5fq1wxz8 33 2 part part NN cord-283202-5fq1wxz8 33 3 , , , cord-283202-5fq1wxz8 33 4 this this DT cord-283202-5fq1wxz8 33 5 may may MD cord-283202-5fq1wxz8 33 6 explain explain VB cord-283202-5fq1wxz8 33 7 the the DT cord-283202-5fq1wxz8 33 8 fact fact NN cord-283202-5fq1wxz8 33 9 that that IN cord-283202-5fq1wxz8 33 10 more more JJR cord-283202-5fq1wxz8 33 11 than than IN cord-283202-5fq1wxz8 33 12 50 50 CD cord-283202-5fq1wxz8 33 13 % % NN cord-283202-5fq1wxz8 33 14 of of IN cord-283202-5fq1wxz8 33 15 cats cat NNS cord-283202-5fq1wxz8 33 16 with with IN cord-283202-5fq1wxz8 33 17 FIP FIP NNP cord-283202-5fq1wxz8 33 18 are be VBP cord-283202-5fq1wxz8 33 19 under under IN cord-283202-5fq1wxz8 33 20 a a DT cord-283202-5fq1wxz8 33 21 year year NN cord-283202-5fq1wxz8 33 22 of of IN cord-283202-5fq1wxz8 33 23 age age NN cord-283202-5fq1wxz8 33 24 . . . cord-283202-5fq1wxz8 34 1 3 3 CD cord-283202-5fq1wxz8 34 2 _SP cord-283202-5fq1wxz8 35 1 The the DT cord-283202-5fq1wxz8 35 2 initial initial JJ cord-283202-5fq1wxz8 35 3 step step NN cord-283202-5fq1wxz8 35 4 in in IN cord-283202-5fq1wxz8 35 5 the the DT cord-283202-5fq1wxz8 35 6 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 35 7 of of IN cord-283202-5fq1wxz8 35 8 FIP FIP NNP cord-283202-5fq1wxz8 35 9 is be VBZ cord-283202-5fq1wxz8 35 10 the the DT cord-283202-5fq1wxz8 35 11 mutation mutation NN cord-283202-5fq1wxz8 35 12 of of IN cord-283202-5fq1wxz8 35 13 FCoV FCoV NNP cord-283202-5fq1wxz8 35 14 , , , cord-283202-5fq1wxz8 35 15 in in IN cord-283202-5fq1wxz8 35 16 the the DT cord-283202-5fq1wxz8 35 17 process process NN cord-283202-5fq1wxz8 35 18 of of IN cord-283202-5fq1wxz8 35 19 which which WDT cord-283202-5fq1wxz8 35 20 the the DT cord-283202-5fq1wxz8 35 21 virus virus NN cord-283202-5fq1wxz8 35 22 gains gain VBZ cord-283202-5fq1wxz8 35 23 the the DT cord-283202-5fq1wxz8 35 24 ability ability NN cord-283202-5fq1wxz8 35 25 to to TO cord-283202-5fq1wxz8 35 26 replicate replicate VB cord-283202-5fq1wxz8 35 27 within within IN cord-283202-5fq1wxz8 35 28 macrophages macrophage NNS cord-283202-5fq1wxz8 35 29 . . . cord-283202-5fq1wxz8 36 1 Once once RB cord-283202-5fq1wxz8 36 2 this this DT cord-283202-5fq1wxz8 36 3 occurs occur VBZ cord-283202-5fq1wxz8 36 4 , , , cord-283202-5fq1wxz8 36 5 the the DT cord-283202-5fq1wxz8 36 6 virus virus NN cord-283202-5fq1wxz8 36 7 can can MD cord-283202-5fq1wxz8 36 8 be be VB cord-283202-5fq1wxz8 36 9 disseminated disseminate VBN cord-283202-5fq1wxz8 36 10 throughout throughout IN cord-283202-5fq1wxz8 36 11 the the DT cord-283202-5fq1wxz8 36 12 body body NN cord-283202-5fq1wxz8 36 13 . . . cord-283202-5fq1wxz8 37 1 Ultimately ultimately RB cord-283202-5fq1wxz8 37 2 , , , cord-283202-5fq1wxz8 37 3 FIP FIP NNP cord-283202-5fq1wxz8 37 4 is be VBZ cord-283202-5fq1wxz8 37 5 an an DT cord-283202-5fq1wxz8 37 6 immune immune JJ cord-283202-5fq1wxz8 37 7 complex complex JJ cord-283202-5fq1wxz8 37 8 disease disease NN cord-283202-5fq1wxz8 37 9 that that WDT cord-283202-5fq1wxz8 37 10 is be VBZ cord-283202-5fq1wxz8 37 11 a a DT cord-283202-5fq1wxz8 37 12 consequence consequence NN cord-283202-5fq1wxz8 37 13 of of IN cord-283202-5fq1wxz8 37 14 virus virus NN cord-283202-5fq1wxz8 37 15 or or CC cord-283202-5fq1wxz8 37 16 viral viral JJ cord-283202-5fq1wxz8 37 17 antigens antigen NNS cord-283202-5fq1wxz8 37 18 complexed complexe VBN cord-283202-5fq1wxz8 37 19 with with IN cord-283202-5fq1wxz8 37 20 antiviral antiviral JJ cord-283202-5fq1wxz8 37 21 antibodies antibody NNS cord-283202-5fq1wxz8 37 22 . . . cord-283202-5fq1wxz8 38 1 16 16 CD cord-283202-5fq1wxz8 39 1 After after IN cord-283202-5fq1wxz8 39 2 distribution distribution NN cord-283202-5fq1wxz8 39 3 by by IN cord-283202-5fq1wxz8 39 4 macrophages macrophage NNS cord-283202-5fq1wxz8 39 5 , , , cord-283202-5fq1wxz8 39 6 the the DT cord-283202-5fq1wxz8 39 7 virus virus NN cord-283202-5fq1wxz8 39 8 may may MD cord-283202-5fq1wxz8 39 9 enter enter VB cord-283202-5fq1wxz8 39 10 tissue tissue NN cord-283202-5fq1wxz8 39 11 and and CC cord-283202-5fq1wxz8 39 12 replicate replicate VB cord-283202-5fq1wxz8 39 13 , , , cord-283202-5fq1wxz8 39 14 resulting result VBG cord-283202-5fq1wxz8 39 15 in in IN cord-283202-5fq1wxz8 39 16 attrac attrac NN cord-283202-5fq1wxz8 39 17 - - HYPH cord-283202-5fq1wxz8 39 18 consisting consist VBG cord-283202-5fq1wxz8 39 19 primarily primarily RB cord-283202-5fq1wxz8 39 20 of of IN cord-283202-5fq1wxz8 39 21 lymphocytes lymphocyte NNS cord-283202-5fq1wxz8 39 22 , , , cord-283202-5fq1wxz8 39 23 macrophages macrophage NNS cord-283202-5fq1wxz8 39 24 , , , cord-283202-5fq1wxz8 39 25 and and CC cord-283202-5fq1wxz8 39 26 varying vary VBG cord-283202-5fq1wxz8 39 27 numbers number NNS cord-283202-5fq1wxz8 39 28 of of IN cord-283202-5fq1wxz8 39 29 plasma plasma NN cord-283202-5fq1wxz8 39 30 cells cell NNS cord-283202-5fq1wxz8 39 31 forming form VBG cord-283202-5fq1wxz8 39 32 perivascular perivascular JJ cord-283202-5fq1wxz8 39 33 cuffs cuff NNS cord-283202-5fq1wxz8 39 34 . . . cord-283202-5fq1wxz8 40 1 18 18 CD cord-283202-5fq1wxz8 41 1 Subependymal Subependymal NNP cord-283202-5fq1wxz8 41 2 periventricular periventricular VBD cord-283202-5fq1wxz8 41 3 inflammatory inflammatory JJ cord-283202-5fq1wxz8 41 4 infiltrate infiltrate NN cord-283202-5fq1wxz8 41 5 may may MD cord-283202-5fq1wxz8 41 6 obstruct obstruct VB cord-283202-5fq1wxz8 41 7 the the DT cord-283202-5fq1wxz8 41 8 mesencephalic mesencephalic NNP cord-283202-5fq1wxz8 41 9 aqueduct aqueduct NN cord-283202-5fq1wxz8 41 10 leading lead VBG cord-283202-5fq1wxz8 41 11 to to IN cord-283202-5fq1wxz8 41 12 obstructive obstructive JJ cord-283202-5fq1wxz8 41 13 hydrocephalus hydrocephalus NN cord-283202-5fq1wxz8 41 14 . . . cord-283202-5fq1wxz8 42 1 Similarly similarly RB cord-283202-5fq1wxz8 42 2 , , , cord-283202-5fq1wxz8 42 3 obstruction obstruction NN cord-283202-5fq1wxz8 42 4 of of IN cord-283202-5fq1wxz8 42 5 the the DT cord-283202-5fq1wxz8 42 6 central central JJ cord-283202-5fq1wxz8 42 7 canal canal NN cord-283202-5fq1wxz8 42 8 of of IN cord-283202-5fq1wxz8 42 9 the the DT cord-283202-5fq1wxz8 42 10 spinal spinal JJ cord-283202-5fq1wxz8 42 11 cord cord NN cord-283202-5fq1wxz8 42 12 may may MD cord-283202-5fq1wxz8 42 13 lead lead VB cord-283202-5fq1wxz8 42 14 to to IN cord-283202-5fq1wxz8 42 15 hydromyelia hydromyelia NNP cord-283202-5fq1wxz8 42 16 . . . cord-283202-5fq1wxz8 43 1 Occasionally occasionally RB cord-283202-5fq1wxz8 43 2 , , , cord-283202-5fq1wxz8 43 3 infiltrate infiltrate VB cord-283202-5fq1wxz8 43 4 extends extend VBZ cord-283202-5fq1wxz8 43 5 into into IN cord-283202-5fq1wxz8 43 6 the the DT cord-283202-5fq1wxz8 43 7 superficial superficial JJ cord-283202-5fq1wxz8 43 8 neuropil neuropil NN cord-283202-5fq1wxz8 43 9 and and CC cord-283202-5fq1wxz8 43 10 cranial cranial JJ cord-283202-5fq1wxz8 43 11 nerve nerve NN cord-283202-5fq1wxz8 43 12 roots root NNS cord-283202-5fq1wxz8 43 13 . . . cord-283202-5fq1wxz8 44 1 18 18 CD cord-283202-5fq1wxz8 44 2 _SP cord-283202-5fq1wxz8 44 3 Hematology Hematology NNP cord-283202-5fq1wxz8 44 4 in in IN cord-283202-5fq1wxz8 44 5 affected affect VBN cord-283202-5fq1wxz8 44 6 cats cat NNS cord-283202-5fq1wxz8 44 7 usually usually RB cord-283202-5fq1wxz8 44 8 reveals reveal VBZ cord-283202-5fq1wxz8 44 9 a a DT cord-283202-5fq1wxz8 44 10 normocytic normocytic JJ cord-283202-5fq1wxz8 44 11 , , , cord-283202-5fq1wxz8 44 12 normochromic normochromic NNP cord-283202-5fq1wxz8 44 13 , , , cord-283202-5fq1wxz8 44 14 nonregenerative nonregenerative JJ cord-283202-5fq1wxz8 44 15 anemia anemia NN cord-283202-5fq1wxz8 44 16 , , , cord-283202-5fq1wxz8 44 17 leukocytosis leukocytosis NNP cord-283202-5fq1wxz8 44 18 consisting consist VBG cord-283202-5fq1wxz8 44 19 of of IN cord-283202-5fq1wxz8 44 20 a a DT cord-283202-5fq1wxz8 44 21 neutrophilia neutrophilia NN cord-283202-5fq1wxz8 44 22 , , , cord-283202-5fq1wxz8 44 23 and and CC cord-283202-5fq1wxz8 44 24 lymphopenia lymphopenia NNP cord-283202-5fq1wxz8 44 25 . . . cord-283202-5fq1wxz8 45 1 22 22 CD cord-283202-5fq1wxz8 45 2 Approximately approximately RB cord-283202-5fq1wxz8 45 3 50 50 CD cord-283202-5fq1wxz8 45 4 % % NN cord-283202-5fq1wxz8 45 5 of of IN cord-283202-5fq1wxz8 45 6 cats cat NNS cord-283202-5fq1wxz8 45 7 with with IN cord-283202-5fq1wxz8 45 8 the the DT cord-283202-5fq1wxz8 45 9 effusive effusive JJ cord-283202-5fq1wxz8 45 10 form form NN cord-283202-5fq1wxz8 45 11 and and CC cord-283202-5fq1wxz8 45 12 70 70 CD cord-283202-5fq1wxz8 45 13 % % NN cord-283202-5fq1wxz8 45 14 of of IN cord-283202-5fq1wxz8 45 15 cats cat NNS cord-283202-5fq1wxz8 45 16 with with IN cord-283202-5fq1wxz8 45 17 the the DT cord-283202-5fq1wxz8 45 18 dry dry JJ cord-283202-5fq1wxz8 45 19 form form NN cord-283202-5fq1wxz8 45 20 have have VBP cord-283202-5fq1wxz8 45 21 increased increase VBN cord-283202-5fq1wxz8 45 22 serum serum NN cord-283202-5fq1wxz8 45 23 proteins protein NNS cord-283202-5fq1wxz8 45 24 , , , cord-283202-5fq1wxz8 45 25 primarily primarily RB cord-283202-5fq1wxz8 45 26 comprising comprise VBG cord-283202-5fq1wxz8 45 27 a a DT cord-283202-5fq1wxz8 45 28 hyperglobulinemia hyperglobulinemia NN cord-283202-5fq1wxz8 45 29 . . . cord-283202-5fq1wxz8 46 1 23 23 CD cord-283202-5fq1wxz8 46 2 Protein Protein NNP cord-283202-5fq1wxz8 46 3 electrophoresis electrophoresis NN cord-283202-5fq1wxz8 46 4 discloses disclose VBZ cord-283202-5fq1wxz8 46 5 a a DT cord-283202-5fq1wxz8 46 6 polyclonal polyclonal JJ cord-283202-5fq1wxz8 46 7 gammopathy gammopathy NN cord-283202-5fq1wxz8 46 8 , , , cord-283202-5fq1wxz8 46 9 mainly mainly RB cord-283202-5fq1wxz8 46 10 involving involve VBG cord-283202-5fq1wxz8 46 11 the the DT cord-283202-5fq1wxz8 46 12 γ γ NN cord-283202-5fq1wxz8 46 13 - - HYPH cord-283202-5fq1wxz8 46 14 globulins globulin NNS cord-283202-5fq1wxz8 46 15 . . . cord-283202-5fq1wxz8 47 1 24 24 CD cord-283202-5fq1wxz8 47 2 Other other JJ cord-283202-5fq1wxz8 47 3 biochemical biochemical JJ cord-283202-5fq1wxz8 47 4 changes change NNS cord-283202-5fq1wxz8 47 5 may may MD cord-283202-5fq1wxz8 47 6 be be VB cord-283202-5fq1wxz8 47 7 observed observe VBN cord-283202-5fq1wxz8 47 8 depending depend VBG cord-283202-5fq1wxz8 47 9 on on IN cord-283202-5fq1wxz8 47 10 the the DT cord-283202-5fq1wxz8 47 11 severity severity NN cord-283202-5fq1wxz8 47 12 of of IN cord-283202-5fq1wxz8 47 13 involvement involvement NN cord-283202-5fq1wxz8 47 14 of of IN cord-283202-5fq1wxz8 47 15 other other JJ cord-283202-5fq1wxz8 47 16 organ organ NN cord-283202-5fq1wxz8 47 17 systems system NNS cord-283202-5fq1wxz8 47 18 including include VBG cord-283202-5fq1wxz8 47 19 abnormal abnormal JJ cord-283202-5fq1wxz8 47 20 liver liver NN cord-283202-5fq1wxz8 47 21 enzyme enzyme NN cord-283202-5fq1wxz8 47 22 , , , cord-283202-5fq1wxz8 47 23 bilirubin bilirubin NN cord-283202-5fq1wxz8 47 24 , , , cord-283202-5fq1wxz8 47 25 blood blood NN cord-283202-5fq1wxz8 47 26 urea urea NN cord-283202-5fq1wxz8 47 27 nitrogen nitrogen NN cord-283202-5fq1wxz8 47 28 and and CC cord-283202-5fq1wxz8 47 29 creatinine creatinine NN cord-283202-5fq1wxz8 47 30 levels level NNS cord-283202-5fq1wxz8 47 31 . . . cord-283202-5fq1wxz8 48 1 25 25 CD cord-283202-5fq1wxz8 49 1 Although although IN cord-283202-5fq1wxz8 49 2 common common JJ cord-283202-5fq1wxz8 49 3 clinicopathologic clinicopathologic JJ cord-283202-5fq1wxz8 49 4 abnormalities abnormality NNS cord-283202-5fq1wxz8 49 5 in in IN cord-283202-5fq1wxz8 49 6 affected affected JJ cord-283202-5fq1wxz8 49 7 cats cat NNS cord-283202-5fq1wxz8 49 8 have have VBP cord-283202-5fq1wxz8 49 9 been be VBN cord-283202-5fq1wxz8 49 10 defined define VBN cord-283202-5fq1wxz8 49 11 , , , cord-283202-5fq1wxz8 49 12 changes change NNS cord-283202-5fq1wxz8 49 13 in in IN cord-283202-5fq1wxz8 49 14 routine routine JJ cord-283202-5fq1wxz8 49 15 hematology hematology NN cord-283202-5fq1wxz8 49 16 and and CC cord-283202-5fq1wxz8 49 17 biochemical biochemical JJ cord-283202-5fq1wxz8 49 18 evaluations evaluation NNS cord-283202-5fq1wxz8 49 19 are be VBP cord-283202-5fq1wxz8 49 20 often often RB cord-283202-5fq1wxz8 49 21 non non JJ cord-283202-5fq1wxz8 49 22 - - JJ cord-283202-5fq1wxz8 49 23 specific specific JJ cord-283202-5fq1wxz8 49 24 . . . cord-283202-5fq1wxz8 50 1 Consequently consequently RB cord-283202-5fq1wxz8 50 2 , , , cord-283202-5fq1wxz8 50 3 establishing establish VBG cord-283202-5fq1wxz8 50 4 a a DT cord-283202-5fq1wxz8 50 5 definitive definitive JJ cord-283202-5fq1wxz8 50 6 ante ante FW cord-283202-5fq1wxz8 50 7 mortem mortem FW cord-283202-5fq1wxz8 50 8 diagnosis diagnosis NN cord-283202-5fq1wxz8 50 9 of of IN cord-283202-5fq1wxz8 50 10 FIP FIP NNP cord-283202-5fq1wxz8 50 11 is be VBZ cord-283202-5fq1wxz8 50 12 extremely extremely RB cord-283202-5fq1wxz8 50 13 challenging challenging JJ cord-283202-5fq1wxz8 50 14 . . . cord-283202-5fq1wxz8 51 1 26 26 CD cord-283202-5fq1wxz8 51 2 Definitive definitive JJ cord-283202-5fq1wxz8 51 3 diagnosis diagnosis NN cord-283202-5fq1wxz8 51 4 can can MD cord-283202-5fq1wxz8 51 5 only only RB cord-283202-5fq1wxz8 51 6 be be VB cord-283202-5fq1wxz8 51 7 achieved achieve VBN cord-283202-5fq1wxz8 51 8 through through IN cord-283202-5fq1wxz8 51 9 histopathological histopathological JJ cord-283202-5fq1wxz8 51 10 identification identification NN cord-283202-5fq1wxz8 51 11 of of IN cord-283202-5fq1wxz8 51 12 pyogranulomatous pyogranulomatous JJ cord-283202-5fq1wxz8 51 13 inflammation inflammation NN cord-283202-5fq1wxz8 51 14 within within IN cord-283202-5fq1wxz8 51 15 tissue tissue NN cord-283202-5fq1wxz8 51 16 coupled couple VBN cord-283202-5fq1wxz8 51 17 with with IN cord-283202-5fq1wxz8 51 18 identification identification NN cord-283202-5fq1wxz8 51 19 of of IN cord-283202-5fq1wxz8 51 20 the the DT cord-283202-5fq1wxz8 51 21 virus virus NN cord-283202-5fq1wxz8 51 22 . . . cord-283202-5fq1wxz8 52 1 16 16 CD cord-283202-5fq1wxz8 52 2 Viral viral JJ cord-283202-5fq1wxz8 52 3 identification identification NN cord-283202-5fq1wxz8 52 4 in in IN cord-283202-5fq1wxz8 52 5 tissue tissue NN cord-283202-5fq1wxz8 52 6 samples sample NNS cord-283202-5fq1wxz8 52 7 can can MD cord-283202-5fq1wxz8 52 8 be be VB cord-283202-5fq1wxz8 52 9 performed perform VBN cord-283202-5fq1wxz8 52 10 using use VBG cord-283202-5fq1wxz8 52 11 immunohistochemistry immunohistochemistry NN cord-283202-5fq1wxz8 52 12 or or CC cord-283202-5fq1wxz8 52 13 through through IN cord-283202-5fq1wxz8 52 14 PCR PCR NNP cord-283202-5fq1wxz8 52 15 testing testing NN cord-283202-5fq1wxz8 52 16 . . . cord-283202-5fq1wxz8 53 1 However however RB cord-283202-5fq1wxz8 53 2 , , , cord-283202-5fq1wxz8 53 3 there there EX cord-283202-5fq1wxz8 53 4 are be VBP cord-283202-5fq1wxz8 53 5 several several JJ cord-283202-5fq1wxz8 53 6 tests test NNS cord-283202-5fq1wxz8 53 7 that that WDT cord-283202-5fq1wxz8 53 8 may may MD cord-283202-5fq1wxz8 53 9 help help VB cord-283202-5fq1wxz8 53 10 support support VB cord-283202-5fq1wxz8 53 11 a a DT cord-283202-5fq1wxz8 53 12 presumptive presumptive JJ cord-283202-5fq1wxz8 53 13 ante ante FW cord-283202-5fq1wxz8 53 14 mortem mortem FW cord-283202-5fq1wxz8 53 15 diagnosis diagnosis NN cord-283202-5fq1wxz8 53 16 . . . cord-283202-5fq1wxz8 54 1 Importantly importantly RB cord-283202-5fq1wxz8 54 2 , , , cord-283202-5fq1wxz8 54 3 interpretation interpretation NN cord-283202-5fq1wxz8 54 4 of of IN cord-283202-5fq1wxz8 54 5 results result NNS cord-283202-5fq1wxz8 54 6 from from IN cord-283202-5fq1wxz8 54 7 such such JJ cord-283202-5fq1wxz8 54 8 tests test NNS cord-283202-5fq1wxz8 54 9 should should MD cord-283202-5fq1wxz8 54 10 be be VB cord-283202-5fq1wxz8 54 11 evaluated evaluate VBN cord-283202-5fq1wxz8 54 12 in in IN cord-283202-5fq1wxz8 54 13 conjunction conjunction NN cord-283202-5fq1wxz8 54 14 with with IN cord-283202-5fq1wxz8 54 15 clinical clinical JJ cord-283202-5fq1wxz8 54 16 signs sign NNS cord-283202-5fq1wxz8 54 17 and and CC cord-283202-5fq1wxz8 54 18 results result NNS cord-283202-5fq1wxz8 54 19 of of IN cord-283202-5fq1wxz8 54 20 other other JJ cord-283202-5fq1wxz8 54 21 diagnostics diagnostic NNS cord-283202-5fq1wxz8 54 22 . . . cord-283202-5fq1wxz8 55 1 Taken take VBN cord-283202-5fq1wxz8 55 2 outside outside IN cord-283202-5fq1wxz8 55 3 the the DT cord-283202-5fq1wxz8 55 4 context context NN cord-283202-5fq1wxz8 55 5 of of IN cord-283202-5fq1wxz8 55 6 signs sign NNS cord-283202-5fq1wxz8 55 7 and and CC cord-283202-5fq1wxz8 55 8 other other JJ cord-283202-5fq1wxz8 55 9 clinicopathologic clinicopathologic JJ cord-283202-5fq1wxz8 55 10 data datum NNS cord-283202-5fq1wxz8 55 11 , , , cord-283202-5fq1wxz8 55 12 most most JJS cord-283202-5fq1wxz8 55 13 tests test NNS cord-283202-5fq1wxz8 55 14 are be VBP cord-283202-5fq1wxz8 55 15 unable unable JJ cord-283202-5fq1wxz8 55 16 to to TO cord-283202-5fq1wxz8 55 17 provide provide VB cord-283202-5fq1wxz8 55 18 a a DT cord-283202-5fq1wxz8 55 19 definitive definitive JJ cord-283202-5fq1wxz8 55 20 diagnosis diagnosis NN cord-283202-5fq1wxz8 55 21 . . . cord-283202-5fq1wxz8 56 1 When when WRB cord-283202-5fq1wxz8 56 2 present present JJ cord-283202-5fq1wxz8 56 3 , , , cord-283202-5fq1wxz8 56 4 effusions effusion NNS cord-283202-5fq1wxz8 56 5 should should MD cord-283202-5fq1wxz8 56 6 be be VB cord-283202-5fq1wxz8 56 7 analyzed analyze VBN cord-283202-5fq1wxz8 56 8 . . . cord-283202-5fq1wxz8 57 1 Typically typically RB cord-283202-5fq1wxz8 57 2 , , , cord-283202-5fq1wxz8 57 3 effusion effusion NN cord-283202-5fq1wxz8 57 4 from from IN cord-283202-5fq1wxz8 57 5 an an DT cord-283202-5fq1wxz8 57 6 affected affected JJ cord-283202-5fq1wxz8 57 7 cat cat NN cord-283202-5fq1wxz8 57 8 should should MD cord-283202-5fq1wxz8 57 9 be be VB cord-283202-5fq1wxz8 57 10 consistent consistent JJ cord-283202-5fq1wxz8 57 11 with with IN cord-283202-5fq1wxz8 57 12 a a DT cord-283202-5fq1wxz8 57 13 modified modify VBN cord-283202-5fq1wxz8 57 14 transudate transudate NN cord-283202-5fq1wxz8 57 15 . . . cord-283202-5fq1wxz8 58 1 3 3 LS cord-283202-5fq1wxz8 58 2 Cats cat NNS cord-283202-5fq1wxz8 58 3 with with IN cord-283202-5fq1wxz8 58 4 neurological neurological JJ cord-283202-5fq1wxz8 58 5 signs sign NNS cord-283202-5fq1wxz8 58 6 should should MD cord-283202-5fq1wxz8 58 7 undergo undergo VB cord-283202-5fq1wxz8 58 8 magnetic magnetic JJ cord-283202-5fq1wxz8 58 9 resonance resonance NN cord-283202-5fq1wxz8 58 10 imaging imaging NN cord-283202-5fq1wxz8 58 11 ( ( -LRB- cord-283202-5fq1wxz8 58 12 MRI MRI NNP cord-283202-5fq1wxz8 58 13 ) ) -RRB- cord-283202-5fq1wxz8 58 14 of of IN cord-283202-5fq1wxz8 58 15 the the DT cord-283202-5fq1wxz8 58 16 brain brain NN cord-283202-5fq1wxz8 58 17 . . . cord-283202-5fq1wxz8 59 1 This this DT cord-283202-5fq1wxz8 59 2 may may MD cord-283202-5fq1wxz8 59 3 disclose disclose VB cord-283202-5fq1wxz8 59 4 hydrocephalus hydrocephalus NN cord-283202-5fq1wxz8 59 5 . . . cord-283202-5fq1wxz8 60 1 18 18 CD cord-283202-5fq1wxz8 61 1 Additionally additionally RB cord-283202-5fq1wxz8 61 2 , , , cord-283202-5fq1wxz8 61 3 T2-weighted t2-weighte VBN cord-283202-5fq1wxz8 61 4 and and CC cord-283202-5fq1wxz8 61 5 T2weighted t2weighted JJ cord-283202-5fq1wxz8 61 6 FLAIR flair NN cord-283202-5fq1wxz8 61 7 images image NNS cord-283202-5fq1wxz8 61 8 may may MD cord-283202-5fq1wxz8 61 9 reveal reveal VB cord-283202-5fq1wxz8 61 10 periventricular periventricular NNP cord-283202-5fq1wxz8 61 11 hyperintensities hyperintensitie NNS cord-283202-5fq1wxz8 61 12 consistent consistent JJ cord-283202-5fq1wxz8 61 13 with with IN cord-283202-5fq1wxz8 61 14 periventriculitis periventriculitis NNP cord-283202-5fq1wxz8 61 15 . . . cord-283202-5fq1wxz8 62 1 18 18 CD cord-283202-5fq1wxz8 63 1 Although although IN cord-283202-5fq1wxz8 63 2 these these DT cord-283202-5fq1wxz8 63 3 findings finding NNS cord-283202-5fq1wxz8 63 4 are be VBP cord-283202-5fq1wxz8 63 5 not not RB cord-283202-5fq1wxz8 63 6 pathognomonic pathognomonic JJ cord-283202-5fq1wxz8 63 7 , , , cord-283202-5fq1wxz8 63 8 MRI MRI NNP cord-283202-5fq1wxz8 63 9 of of IN cord-283202-5fq1wxz8 63 10 the the DT cord-283202-5fq1wxz8 63 11 brain brain NN cord-283202-5fq1wxz8 63 12 should should MD cord-283202-5fq1wxz8 63 13 be be VB cord-283202-5fq1wxz8 63 14 pursued pursue VBN cord-283202-5fq1wxz8 63 15 in in IN cord-283202-5fq1wxz8 63 16 order order NN cord-283202-5fq1wxz8 63 17 to to TO cord-283202-5fq1wxz8 63 18 eliminate eliminate VB cord-283202-5fq1wxz8 63 19 the the DT cord-283202-5fq1wxz8 63 20 potential potential NN cord-283202-5fq1wxz8 63 21 that that IN cord-283202-5fq1wxz8 63 22 clinical clinical JJ cord-283202-5fq1wxz8 63 23 signs sign NNS cord-283202-5fq1wxz8 63 24 may may MD cord-283202-5fq1wxz8 63 25 be be VB cord-283202-5fq1wxz8 63 26 a a DT cord-283202-5fq1wxz8 63 27 consequence consequence NN cord-283202-5fq1wxz8 63 28 of of IN cord-283202-5fq1wxz8 63 29 a a DT cord-283202-5fq1wxz8 63 30 disease disease NN cord-283202-5fq1wxz8 63 31 process process NN cord-283202-5fq1wxz8 63 32 other other JJ cord-283202-5fq1wxz8 63 33 than than IN cord-283202-5fq1wxz8 63 34 FIPV FIPV NNS cord-283202-5fq1wxz8 63 35 . . . cord-283202-5fq1wxz8 64 1 Analysis analysis NN cord-283202-5fq1wxz8 64 2 of of IN cord-283202-5fq1wxz8 64 3 cerebrospinal cerebrospinal NN cord-283202-5fq1wxz8 64 4 fluid fluid NN cord-283202-5fq1wxz8 64 5 ( ( -LRB- cord-283202-5fq1wxz8 64 6 CSF CSF NNP cord-283202-5fq1wxz8 64 7 ) ) -RRB- cord-283202-5fq1wxz8 64 8 often often RB cord-283202-5fq1wxz8 64 9 reveals reveal VBZ cord-283202-5fq1wxz8 64 10 increased increase VBN cord-283202-5fq1wxz8 64 11 protein protein NN cord-283202-5fq1wxz8 64 12 content content NN cord-283202-5fq1wxz8 64 13 ( ( -LRB- cord-283202-5fq1wxz8 64 14 50 50 CD cord-283202-5fq1wxz8 64 15 - - SYM cord-283202-5fq1wxz8 64 16 350 350 CD cord-283202-5fq1wxz8 64 17 mg mg NNP cord-283202-5fq1wxz8 64 18 / / SYM cord-283202-5fq1wxz8 64 19 dl dl NNP cord-283202-5fq1wxz8 64 20 ) ) -RRB- cord-283202-5fq1wxz8 64 21 with with IN cord-283202-5fq1wxz8 64 22 a a DT cord-283202-5fq1wxz8 64 23 pleocytosis pleocytosis NN cord-283202-5fq1wxz8 64 24 consisting consist VBG cord-283202-5fq1wxz8 64 25 of of IN cord-283202-5fq1wxz8 64 26 neutrophils neutrophil NNS cord-283202-5fq1wxz8 64 27 , , , cord-283202-5fq1wxz8 64 28 lymphocytes lymphocyte NNS cord-283202-5fq1wxz8 64 29 and and CC cord-283202-5fq1wxz8 64 30 macrophages macrophage NNS cord-283202-5fq1wxz8 64 31 . . . cord-283202-5fq1wxz8 65 1 20 20 CD cord-283202-5fq1wxz8 65 2 , , , cord-283202-5fq1wxz8 65 3 27 27 CD cord-283202-5fq1wxz8 65 4 , , , cord-283202-5fq1wxz8 65 5 28 28 CD cord-283202-5fq1wxz8 66 1 The the DT cord-283202-5fq1wxz8 66 2 evaluation evaluation NN cord-283202-5fq1wxz8 66 3 of of IN cord-283202-5fq1wxz8 66 4 FCoV FCoV NNP cord-283202-5fq1wxz8 66 5 antibody antibody NN cord-283202-5fq1wxz8 66 6 titers titer NNS cord-283202-5fq1wxz8 66 7 ( ( -LRB- cord-283202-5fq1wxz8 66 8 often often RB cord-283202-5fq1wxz8 66 9 erroneously erroneously RB cord-283202-5fq1wxz8 66 10 referred refer VBN cord-283202-5fq1wxz8 66 11 to to IN cord-283202-5fq1wxz8 66 12 as as IN cord-283202-5fq1wxz8 66 13 an an DT cord-283202-5fq1wxz8 66 14 ' ' `` cord-283202-5fq1wxz8 66 15 FIP FIP NNP cord-283202-5fq1wxz8 66 16 titer titer NN cord-283202-5fq1wxz8 66 17 ' ' '' cord-283202-5fq1wxz8 66 18 ) ) -RRB- cord-283202-5fq1wxz8 66 19 in in IN cord-283202-5fq1wxz8 66 20 blood blood NN cord-283202-5fq1wxz8 66 21 and and CC cord-283202-5fq1wxz8 66 22 other other JJ cord-283202-5fq1wxz8 66 23 fluids fluid NNS cord-283202-5fq1wxz8 66 24 has have VBZ cord-283202-5fq1wxz8 66 25 been be VBN cord-283202-5fq1wxz8 66 26 extensively extensively RB cord-283202-5fq1wxz8 66 27 studied study VBN cord-283202-5fq1wxz8 66 28 . . . cord-283202-5fq1wxz8 67 1 However however RB cord-283202-5fq1wxz8 67 2 , , , cord-283202-5fq1wxz8 67 3 despite despite IN cord-283202-5fq1wxz8 67 4 years year NNS cord-283202-5fq1wxz8 67 5 of of IN cord-283202-5fq1wxz8 67 6 investigation investigation NN cord-283202-5fq1wxz8 67 7 , , , cord-283202-5fq1wxz8 67 8 caution caution NN cord-283202-5fq1wxz8 67 9 should should MD cord-283202-5fq1wxz8 67 10 be be VB cord-283202-5fq1wxz8 67 11 exercised exercise VBN cord-283202-5fq1wxz8 67 12 when when WRB cord-283202-5fq1wxz8 67 13 interpreting interpret VBG cord-283202-5fq1wxz8 67 14 FCoV fcov JJ cord-283202-5fq1wxz8 67 15 antibody antibody NN cord-283202-5fq1wxz8 67 16 titers titer NNS cord-283202-5fq1wxz8 67 17 in in IN cord-283202-5fq1wxz8 67 18 blood blood NN cord-283202-5fq1wxz8 67 19 and and CC cord-283202-5fq1wxz8 67 20 effusions effusion NNS cord-283202-5fq1wxz8 67 21 as as IN cord-283202-5fq1wxz8 67 22 high high JJ cord-283202-5fq1wxz8 67 23 titers titer NNS cord-283202-5fq1wxz8 67 24 can can MD cord-283202-5fq1wxz8 67 25 be be VB cord-283202-5fq1wxz8 67 26 observed observe VBN cord-283202-5fq1wxz8 67 27 in in IN cord-283202-5fq1wxz8 67 28 healthy healthy JJ cord-283202-5fq1wxz8 67 29 cats cat NNS cord-283202-5fq1wxz8 67 30 and and CC cord-283202-5fq1wxz8 67 31 low low JJ cord-283202-5fq1wxz8 67 32 to to IN cord-283202-5fq1wxz8 67 33 absent absent JJ cord-283202-5fq1wxz8 67 34 titers titer NNS cord-283202-5fq1wxz8 67 35 in in IN cord-283202-5fq1wxz8 67 36 affected affected JJ cord-283202-5fq1wxz8 67 37 cats cat NNS cord-283202-5fq1wxz8 67 38 . . . cord-283202-5fq1wxz8 68 1 3 3 CD cord-283202-5fq1wxz8 68 2 ✜ ✜ NN cord-283202-5fq1wxz8 68 3 FIPV FIPV NNS cord-283202-5fq1wxz8 68 4 is be VBZ cord-283202-5fq1wxz8 68 5 fatal fatal JJ cord-283202-5fq1wxz8 68 6 and and CC cord-283202-5fq1wxz8 68 7 treatment treatment NN cord-283202-5fq1wxz8 68 8 is be VBZ cord-283202-5fq1wxz8 68 9 mainly mainly RB cord-283202-5fq1wxz8 68 10 palliative palliative JJ cord-283202-5fq1wxz8 68 11 . . . cord-283202-5fq1wxz8 69 1 Since since IN cord-283202-5fq1wxz8 69 2 FIP FIP NNP cord-283202-5fq1wxz8 69 3 is be VBZ cord-283202-5fq1wxz8 69 4 an an DT cord-283202-5fq1wxz8 69 5 immune immune NN cord-283202-5fq1wxz8 69 6 - - HYPH cord-283202-5fq1wxz8 69 7 mediated mediate VBN cord-283202-5fq1wxz8 69 8 disease disease NN cord-283202-5fq1wxz8 69 9 process process NN cord-283202-5fq1wxz8 69 10 , , , cord-283202-5fq1wxz8 69 11 therapy therapy NN cord-283202-5fq1wxz8 69 12 has have VBZ cord-283202-5fq1wxz8 69 13 been be VBN cord-283202-5fq1wxz8 69 14 directed direct VBN cord-283202-5fq1wxz8 69 15 at at IN cord-283202-5fq1wxz8 69 16 immunosuppression immunosuppression NN cord-283202-5fq1wxz8 69 17 and/or and/or CC cord-283202-5fq1wxz8 69 18 immunomodulation immunomodulation NN cord-283202-5fq1wxz8 69 19 with with IN cord-283202-5fq1wxz8 69 20 the the DT cord-283202-5fq1wxz8 69 21 goal goal NN cord-283202-5fq1wxz8 69 22 of of IN cord-283202-5fq1wxz8 69 23 providing provide VBG cord-283202-5fq1wxz8 69 24 symptomatic symptomatic JJ cord-283202-5fq1wxz8 69 25 care care NN cord-283202-5fq1wxz8 69 26 . . . cord-283202-5fq1wxz8 70 1 Immunosuppressive immunosuppressive JJ cord-283202-5fq1wxz8 70 2 therapy therapy NN cord-283202-5fq1wxz8 70 3 using use VBG cord-283202-5fq1wxz8 70 4 corticosteroids corticosteroid NNS cord-283202-5fq1wxz8 70 5 ( ( -LRB- cord-283202-5fq1wxz8 70 6 prednisone prednisone NN cord-283202-5fq1wxz8 70 7 at at IN cord-283202-5fq1wxz8 70 8 2 2 CD cord-283202-5fq1wxz8 70 9 - - SYM cord-283202-5fq1wxz8 70 10 4 4 CD cord-283202-5fq1wxz8 70 11 mg mg NNP cord-283202-5fq1wxz8 70 12 / / SYM cord-283202-5fq1wxz8 70 13 kg kg NNP cord-283202-5fq1wxz8 70 14 / / SYM cord-283202-5fq1wxz8 70 15 day day NN cord-283202-5fq1wxz8 70 16 ) ) -RRB- cord-283202-5fq1wxz8 70 17 may may MD cord-283202-5fq1wxz8 70 18 allow allow VB cord-283202-5fq1wxz8 70 19 mildly mildly RB cord-283202-5fq1wxz8 70 20 affected affect VBN cord-283202-5fq1wxz8 70 21 cats cat NNS cord-283202-5fq1wxz8 70 22 to to TO cord-283202-5fq1wxz8 70 23 maintain maintain VB cord-283202-5fq1wxz8 70 24 an an DT cord-283202-5fq1wxz8 70 25 acceptable acceptable JJ cord-283202-5fq1wxz8 70 26 quality quality NN cord-283202-5fq1wxz8 70 27 of of IN cord-283202-5fq1wxz8 70 28 life life NN cord-283202-5fq1wxz8 70 29 for for IN cord-283202-5fq1wxz8 70 30 weeks week NNS cord-283202-5fq1wxz8 70 31 to to IN cord-283202-5fq1wxz8 70 32 months month NNS cord-283202-5fq1wxz8 70 33 . . . cord-283202-5fq1wxz8 71 1 In in IN cord-283202-5fq1wxz8 71 2 addition addition NN cord-283202-5fq1wxz8 71 3 to to IN cord-283202-5fq1wxz8 71 4 corticosteroids corticosteroid NNS cord-283202-5fq1wxz8 71 5 , , , cord-283202-5fq1wxz8 71 6 a a DT cord-283202-5fq1wxz8 71 7 wide wide JJ cord-283202-5fq1wxz8 71 8 array array NN cord-283202-5fq1wxz8 71 9 of of IN cord-283202-5fq1wxz8 71 10 drugs drug NNS cord-283202-5fq1wxz8 71 11 including include VBG cord-283202-5fq1wxz8 71 12 chemotherapy chemotherapy NN cord-283202-5fq1wxz8 71 13 agents agent NNS cord-283202-5fq1wxz8 71 14 ( ( -LRB- cord-283202-5fq1wxz8 71 15 cyclophosphamide cyclophosphamide NN cord-283202-5fq1wxz8 71 16 and and CC cord-283202-5fq1wxz8 71 17 melphalan melphalan NNP cord-283202-5fq1wxz8 71 18 ) ) -RRB- cord-283202-5fq1wxz8 71 19 , , , cord-283202-5fq1wxz8 71 20 an an DT cord-283202-5fq1wxz8 71 21 antiviral antiviral JJ cord-283202-5fq1wxz8 71 22 ( ( -LRB- cord-283202-5fq1wxz8 71 23 ribavrin ribavrin NNP cord-283202-5fq1wxz8 71 24 ) ) -RRB- cord-283202-5fq1wxz8 71 25 , , , cord-283202-5fq1wxz8 71 26 a a DT cord-283202-5fq1wxz8 71 27 thromboxane thromboxane NN cord-283202-5fq1wxz8 71 28 synthetase synthetase NN cord-283202-5fq1wxz8 71 29 inihibitor inihibitor NN cord-283202-5fq1wxz8 71 30 ( ( -LRB- cord-283202-5fq1wxz8 71 31 ozagrel ozagrel NNP cord-283202-5fq1wxz8 71 32 hydrochloride hydrochloride NNP cord-283202-5fq1wxz8 71 33 ) ) -RRB- cord-283202-5fq1wxz8 71 34 and and CC cord-283202-5fq1wxz8 71 35 a a DT cord-283202-5fq1wxz8 71 36 variety variety NN cord-283202-5fq1wxz8 71 37 of of IN cord-283202-5fq1wxz8 71 38 immunomodulating immunomodulate VBG cord-283202-5fq1wxz8 71 39 drugs drug NNS cord-283202-5fq1wxz8 71 40 ( ( -LRB- cord-283202-5fq1wxz8 71 41 promodulin promodulin NNP cord-283202-5fq1wxz8 71 42 , , , cord-283202-5fq1wxz8 71 43 human human JJ cord-283202-5fq1wxz8 71 44 interferon interferon NN cord-283202-5fq1wxz8 71 45 - - HYPH cord-283202-5fq1wxz8 71 46 α α NN cord-283202-5fq1wxz8 71 47 , , , cord-283202-5fq1wxz8 71 48 Propionibacterium Propionibacterium NNP cord-283202-5fq1wxz8 71 49 acnes acne NNS cord-283202-5fq1wxz8 71 50 , , , cord-283202-5fq1wxz8 71 51 and and CC cord-283202-5fq1wxz8 71 52 feline feline JJ cord-283202-5fq1wxz8 71 53 interferon interferon NN cord-283202-5fq1wxz8 71 54 - - HYPH cord-283202-5fq1wxz8 71 55 ω ω JJS cord-283202-5fq1wxz8 71 56 ) ) -RRB- cord-283202-5fq1wxz8 71 57 have have VBP cord-283202-5fq1wxz8 71 58 been be VBN cord-283202-5fq1wxz8 71 59 investigated investigate VBN cord-283202-5fq1wxz8 71 60 . . . cord-283202-5fq1wxz8 72 1 36 36 CD cord-283202-5fq1wxz8 73 1 The the DT cord-283202-5fq1wxz8 73 2 interpretation interpretation NN cord-283202-5fq1wxz8 73 3 of of IN cord-283202-5fq1wxz8 73 4 results result NNS cord-283202-5fq1wxz8 73 5 from from IN cord-283202-5fq1wxz8 73 6 most most JJS cord-283202-5fq1wxz8 73 7 studies study NNS cord-283202-5fq1wxz8 73 8 has have VBZ cord-283202-5fq1wxz8 73 9 been be VBN cord-283202-5fq1wxz8 73 10 hindered hinder VBN cord-283202-5fq1wxz8 73 11 by by IN cord-283202-5fq1wxz8 73 12 a a DT cord-283202-5fq1wxz8 73 13 lack lack NN cord-283202-5fq1wxz8 73 14 of of IN cord-283202-5fq1wxz8 73 15 control control NN cord-283202-5fq1wxz8 73 16 groups group NNS cord-283202-5fq1wxz8 73 17 and and CC cord-283202-5fq1wxz8 73 18 the the DT cord-283202-5fq1wxz8 73 19 difficulty difficulty NN cord-283202-5fq1wxz8 73 20 in in IN cord-283202-5fq1wxz8 73 21 establishing establish VBG cord-283202-5fq1wxz8 73 22 a a DT cord-283202-5fq1wxz8 73 23 definitive definitive JJ cord-283202-5fq1wxz8 73 24 diagnosis diagnosis NN cord-283202-5fq1wxz8 73 25 of of IN cord-283202-5fq1wxz8 73 26 FIP FIP NNP cord-283202-5fq1wxz8 73 27 in in IN cord-283202-5fq1wxz8 73 28 treated treat VBN cord-283202-5fq1wxz8 73 29 cats cat NNS cord-283202-5fq1wxz8 73 30 . . . cord-283202-5fq1wxz8 74 1 36 36 CD cord-283202-5fq1wxz8 74 2 Still still RB cord-283202-5fq1wxz8 74 3 , , , cord-283202-5fq1wxz8 74 4 most most RBS cord-283202-5fq1wxz8 74 5 therapeutic therapeutic JJ cord-283202-5fq1wxz8 74 6 trials trial NNS cord-283202-5fq1wxz8 74 7 have have VBP cord-283202-5fq1wxz8 74 8 failed fail VBN cord-283202-5fq1wxz8 74 9 and and CC cord-283202-5fq1wxz8 74 10 , , , cord-283202-5fq1wxz8 74 11 disappointingly disappointingly RB cord-283202-5fq1wxz8 74 12 , , , cord-283202-5fq1wxz8 74 13 an an DT cord-283202-5fq1wxz8 74 14 effective effective JJ cord-283202-5fq1wxz8 74 15 treatment treatment NN cord-283202-5fq1wxz8 74 16 regime regime NN cord-283202-5fq1wxz8 74 17 remains remain VBZ cord-283202-5fq1wxz8 74 18 elusive elusive JJ cord-283202-5fq1wxz8 74 19 . . . cord-283202-5fq1wxz8 75 1 presence presence NN cord-283202-5fq1wxz8 75 2 of of IN cord-283202-5fq1wxz8 75 3 neurological neurological JJ cord-283202-5fq1wxz8 75 4 FIPV FIPV NNS cord-283202-5fq1wxz8 75 5 . . . cord-283202-5fq1wxz8 76 1 18 18 CD cord-283202-5fq1wxz8 76 2 Cerebrospinal cerebrospinal NN cord-283202-5fq1wxz8 76 3 fluid fluid JJ cord-283202-5fq1wxz8 76 4 FCoV FCoV NNP cord-283202-5fq1wxz8 76 5 antibody antibody NN cord-283202-5fq1wxz8 76 6 titers titer NNS cord-283202-5fq1wxz8 76 7 correlate correlate VBP cord-283202-5fq1wxz8 76 8 with with IN cord-283202-5fq1wxz8 76 9 serum serum NN cord-283202-5fq1wxz8 76 10 FCoV fcov NN cord-283202-5fq1wxz8 76 11 antibody antibody NN cord-283202-5fq1wxz8 76 12 titers titer NNS cord-283202-5fq1wxz8 77 1 but but CC cord-283202-5fq1wxz8 77 2 , , , cord-283202-5fq1wxz8 77 3 most most RBS cord-283202-5fq1wxz8 77 4 importantly importantly RB cord-283202-5fq1wxz8 77 5 , , , cord-283202-5fq1wxz8 77 6 elevated elevate VBD cord-283202-5fq1wxz8 77 7 CSF CSF NNP cord-283202-5fq1wxz8 77 8 FCoV FCoV NNP cord-283202-5fq1wxz8 77 9 antibody antibody NN cord-283202-5fq1wxz8 77 10 titers titer NNS cord-283202-5fq1wxz8 77 11 may may MD cord-283202-5fq1wxz8 77 12 also also RB cord-283202-5fq1wxz8 77 13 be be VB cord-283202-5fq1wxz8 77 14 observed observe VBN cord-283202-5fq1wxz8 77 15 in in IN cord-283202-5fq1wxz8 77 16 cats cat NNS cord-283202-5fq1wxz8 77 17 affected affect VBN cord-283202-5fq1wxz8 77 18 by by IN cord-283202-5fq1wxz8 77 19 neurological neurological JJ cord-283202-5fq1wxz8 77 20 diseases disease NNS cord-283202-5fq1wxz8 77 21 other other JJ cord-283202-5fq1wxz8 77 22 than than IN cord-283202-5fq1wxz8 77 23 FIP FIP NNP cord-283202-5fq1wxz8 77 24 . . . cord-283202-5fq1wxz8 78 1 29 29 CD cord-283202-5fq1wxz8 79 1 While while IN cord-283202-5fq1wxz8 79 2 PCR PCR NNP cord-283202-5fq1wxz8 79 3 assays assay NNS cord-283202-5fq1wxz8 79 4 can can MD cord-283202-5fq1wxz8 79 5 be be VB cord-283202-5fq1wxz8 79 6 performed perform VBN cord-283202-5fq1wxz8 79 7 on on IN cord-283202-5fq1wxz8 79 8 blood blood NN cord-283202-5fq1wxz8 79 9 and and CC cord-283202-5fq1wxz8 79 10 effusions effusion NNS cord-283202-5fq1wxz8 79 11 in in IN cord-283202-5fq1wxz8 79 12 affected affect VBN cord-283202-5fq1wxz8 79 13 cats cat NNS cord-283202-5fq1wxz8 79 14 , , , cord-283202-5fq1wxz8 79 15 they -PRON- PRP cord-283202-5fq1wxz8 79 16 are be VBP cord-283202-5fq1wxz8 79 17 unable unable JJ cord-283202-5fq1wxz8 79 18 to to TO cord-283202-5fq1wxz8 79 19 distinguish distinguish VB cord-283202-5fq1wxz8 79 20 between between IN cord-283202-5fq1wxz8 79 21 the the DT cord-283202-5fq1wxz8 79 22 mutated mutate VBN cord-283202-5fq1wxz8 79 23 FCoV FCoV NNP cord-283202-5fq1wxz8 79 24 causing cause VBG cord-283202-5fq1wxz8 79 25 FIP fip NN cord-283202-5fq1wxz8 79 26 , , , cord-283202-5fq1wxz8 79 27 and and CC cord-283202-5fq1wxz8 79 28 the the DT cord-283202-5fq1wxz8 79 29 non non JJ cord-283202-5fq1wxz8 79 30 - - JJ cord-283202-5fq1wxz8 79 31 pathogenic pathogenic JJ cord-283202-5fq1wxz8 79 32 FCoV. fcov. CD cord-283202-5fq1wxz8 79 33 30 30 CD cord-283202-5fq1wxz8 80 1 In in IN cord-283202-5fq1wxz8 80 2 addition addition NN cord-283202-5fq1wxz8 80 3 , , , cord-283202-5fq1wxz8 80 4 healthy healthy JJ cord-283202-5fq1wxz8 80 5 cats cat NNS cord-283202-5fq1wxz8 80 6 can can MD cord-283202-5fq1wxz8 80 7 be be VB cord-283202-5fq1wxz8 80 8 viremic viremic JJ cord-283202-5fq1wxz8 80 9 with with IN cord-283202-5fq1wxz8 80 10 FCoV. fcov. CD cord-283202-5fq1wxz8 80 11 31 31 CD cord-283202-5fq1wxz8 81 1 Therefore therefore RB cord-283202-5fq1wxz8 81 2 , , , cord-283202-5fq1wxz8 81 3 PCR PCR NNP cord-283202-5fq1wxz8 81 4 identification identification NN cord-283202-5fq1wxz8 81 5 of of IN cord-283202-5fq1wxz8 81 6 virus virus NN cord-283202-5fq1wxz8 81 7 in in IN cord-283202-5fq1wxz8 81 8 blood blood NN cord-283202-5fq1wxz8 81 9 or or CC cord-283202-5fq1wxz8 81 10 effusions effusion NNS cord-283202-5fq1wxz8 81 11 does do VBZ cord-283202-5fq1wxz8 81 12 not not RB cord-283202-5fq1wxz8 81 13 provide provide VB cord-283202-5fq1wxz8 81 14 a a DT cord-283202-5fq1wxz8 81 15 definitive definitive JJ cord-283202-5fq1wxz8 81 16 diagnosis diagnosis NN cord-283202-5fq1wxz8 81 17 . . . cord-283202-5fq1wxz8 82 1 32 32 CD cord-283202-5fq1wxz8 83 1 While while IN cord-283202-5fq1wxz8 83 2 its -PRON- PRP$ cord-283202-5fq1wxz8 83 3 application application NN cord-283202-5fq1wxz8 83 4 in in IN cord-283202-5fq1wxz8 83 5 CSF CSF NNP cord-283202-5fq1wxz8 83 6 has have VBZ cord-283202-5fq1wxz8 83 7 not not RB cord-283202-5fq1wxz8 83 8 been be VBN cord-283202-5fq1wxz8 83 9 studied study VBN cord-283202-5fq1wxz8 83 10 , , , cord-283202-5fq1wxz8 83 11 PCR PCR NNP cord-283202-5fq1wxz8 83 12 identification identification NN cord-283202-5fq1wxz8 83 13 of of IN cord-283202-5fq1wxz8 83 14 virus virus NN cord-283202-5fq1wxz8 83 15 in in IN cord-283202-5fq1wxz8 83 16 CSF CSF NNP cord-283202-5fq1wxz8 83 17 may may MD cord-283202-5fq1wxz8 83 18 allow allow VB cord-283202-5fq1wxz8 83 19 a a DT cord-283202-5fq1wxz8 83 20 definitive definitive JJ cord-283202-5fq1wxz8 83 21 diagnosis diagnosis NN cord-283202-5fq1wxz8 83 22 of of IN cord-283202-5fq1wxz8 83 23 FIP FIP NNP cord-283202-5fq1wxz8 83 24 . . . cord-283202-5fq1wxz8 84 1 Measurement measurement NN cord-283202-5fq1wxz8 84 2 of of IN cord-283202-5fq1wxz8 84 3 serum serum NN cord-283202-5fq1wxz8 84 4 α1-acid α1-acid XX cord-283202-5fq1wxz8 84 5 glypoprotein glypoprotein NNP cord-283202-5fq1wxz8 84 6 ( ( -LRB- cord-283202-5fq1wxz8 84 7 AGP AGP NNP cord-283202-5fq1wxz8 84 8 ) ) -RRB- cord-283202-5fq1wxz8 84 9 , , , cord-283202-5fq1wxz8 84 10 an an DT cord-283202-5fq1wxz8 84 11 acute acute JJ cord-283202-5fq1wxz8 84 12 phase phase NN cord-283202-5fq1wxz8 84 13 protein protein NN cord-283202-5fq1wxz8 84 14 that that WDT cord-283202-5fq1wxz8 84 15 increases increase VBZ cord-283202-5fq1wxz8 84 16 during during IN cord-283202-5fq1wxz8 84 17 inflammation inflammation NN cord-283202-5fq1wxz8 84 18 , , , cord-283202-5fq1wxz8 84 19 has have VBZ cord-283202-5fq1wxz8 84 20 been be VBN cord-283202-5fq1wxz8 84 21 used use VBN cord-283202-5fq1wxz8 84 22 in in IN cord-283202-5fq1wxz8 84 23 the the DT cord-283202-5fq1wxz8 84 24 diagnosis diagnosis NN cord-283202-5fq1wxz8 84 25 of of IN cord-283202-5fq1wxz8 84 26 FIP FIP NNP cord-283202-5fq1wxz8 84 27 . . . cord-283202-5fq1wxz8 85 1 33 33 CD cord-283202-5fq1wxz8 85 2 , , , cord-283202-5fq1wxz8 85 3 34 34 CD cord-283202-5fq1wxz8 86 1 In in IN cord-283202-5fq1wxz8 86 2 cats cat NNS cord-283202-5fq1wxz8 86 3 with with IN cord-283202-5fq1wxz8 86 4 signs sign NNS cord-283202-5fq1wxz8 86 5 and and CC cord-283202-5fq1wxz8 86 6 clinicopathologic clinicopathologic JJ cord-283202-5fq1wxz8 86 7 data datum NNS cord-283202-5fq1wxz8 86 8 highly highly RB cord-283202-5fq1wxz8 86 9 suggestive suggestive JJ cord-283202-5fq1wxz8 86 10 of of IN cord-283202-5fq1wxz8 86 11 FIP fip NN cord-283202-5fq1wxz8 86 12 , , , cord-283202-5fq1wxz8 86 13 elevation elevation NN cord-283202-5fq1wxz8 86 14 in in IN cord-283202-5fq1wxz8 86 15 serum serum NN cord-283202-5fq1wxz8 86 16 AGP AGP NNP cord-283202-5fq1wxz8 86 17 provides provide VBZ cord-283202-5fq1wxz8 86 18 strong strong JJ cord-283202-5fq1wxz8 86 19 supportive supportive JJ cord-283202-5fq1wxz8 86 20 evidence evidence NN cord-283202-5fq1wxz8 86 21 of of IN cord-283202-5fq1wxz8 86 22 FIPV FIPV NNS cord-283202-5fq1wxz8 86 23 infection infection NN cord-283202-5fq1wxz8 86 24 . . . cord-283202-5fq1wxz8 87 1 33 33 CD cord-283202-5fq1wxz8 88 1 However however RB cord-283202-5fq1wxz8 88 2 , , , cord-283202-5fq1wxz8 88 3 AGP AGP NNP cord-283202-5fq1wxz8 88 4 may may MD cord-283202-5fq1wxz8 88 5 also also RB cord-283202-5fq1wxz8 88 6 increase increase VB cord-283202-5fq1wxz8 88 7 in in IN cord-283202-5fq1wxz8 88 8 other other JJ cord-283202-5fq1wxz8 88 9 conditions condition NNS cord-283202-5fq1wxz8 88 10 associated associate VBN cord-283202-5fq1wxz8 88 11 with with IN cord-283202-5fq1wxz8 88 12 inflammation inflammation NN cord-283202-5fq1wxz8 88 13 , , , cord-283202-5fq1wxz8 88 14 such such JJ cord-283202-5fq1wxz8 88 15 as as IN cord-283202-5fq1wxz8 88 16 feline feline JJ cord-283202-5fq1wxz8 88 17 immunodeficiency immunodeficiency NN cord-283202-5fq1wxz8 88 18 virus virus NN cord-283202-5fq1wxz8 88 19 ( ( -LRB- cord-283202-5fq1wxz8 88 20 FIV fiv NN cord-283202-5fq1wxz8 88 21 ) ) -RRB- cord-283202-5fq1wxz8 88 22 infection infection NN cord-283202-5fq1wxz8 88 23 , , , cord-283202-5fq1wxz8 88 24 or or CC cord-283202-5fq1wxz8 88 25 in in IN cord-283202-5fq1wxz8 88 26 cats cat NNS cord-283202-5fq1wxz8 88 27 with with IN cord-283202-5fq1wxz8 88 28 a a DT cord-283202-5fq1wxz8 88 29 high high JJ cord-283202-5fq1wxz8 88 30 viral viral JJ cord-283202-5fq1wxz8 88 31 load load NN cord-283202-5fq1wxz8 88 32 of of IN cord-283202-5fq1wxz8 88 33 FECV FECV NNP cord-283202-5fq1wxz8 88 34 , , , cord-283202-5fq1wxz8 88 35 which which WDT cord-283202-5fq1wxz8 88 36 may may MD cord-283202-5fq1wxz8 88 37 limit limit VB cord-283202-5fq1wxz8 88 38 its -PRON- PRP$ cord-283202-5fq1wxz8 88 39 potential potential NN cord-283202-5fq1wxz8 88 40 as as IN cord-283202-5fq1wxz8 88 41 a a DT cord-283202-5fq1wxz8 88 42 diagnostic diagnostic JJ cord-283202-5fq1wxz8 88 43 tool tool NN cord-283202-5fq1wxz8 88 44 for for IN cord-283202-5fq1wxz8 88 45 FIP FIP NNP cord-283202-5fq1wxz8 88 46 . . . cord-283202-5fq1wxz8 89 1 34 34 CD cord-283202-5fq1wxz8 89 2 , , , cord-283202-5fq1wxz8 89 3 35 35 CD cord-283202-5fq1wxz8 90 1 Prognosis prognosis NN cord-283202-5fq1wxz8 91 1 Unfortunately unfortunately RB cord-283202-5fq1wxz8 91 2 , , , cord-283202-5fq1wxz8 91 3 the the DT cord-283202-5fq1wxz8 91 4 prognosis prognosis NN cord-283202-5fq1wxz8 91 5 for for IN cord-283202-5fq1wxz8 91 6 cats cat NNS cord-283202-5fq1wxz8 91 7 with with IN cord-283202-5fq1wxz8 91 8 FIP FIP NNP cord-283202-5fq1wxz8 91 9 is be VBZ cord-283202-5fq1wxz8 91 10 grave grave JJ cord-283202-5fq1wxz8 91 11 as as IN cord-283202-5fq1wxz8 91 12 all all DT cord-283202-5fq1wxz8 91 13 affected affect VBN cord-283202-5fq1wxz8 91 14 cats cat NNS cord-283202-5fq1wxz8 91 15 succumb succumb VBP cord-283202-5fq1wxz8 91 16 to to IN cord-283202-5fq1wxz8 91 17 the the DT cord-283202-5fq1wxz8 91 18 disease disease NN cord-283202-5fq1wxz8 91 19 . . . cord-283202-5fq1wxz8 92 1 To to IN cord-283202-5fq1wxz8 92 2 date date NN cord-283202-5fq1wxz8 92 3 , , , cord-283202-5fq1wxz8 92 4 no no DT cord-283202-5fq1wxz8 92 5 therapy therapy NN cord-283202-5fq1wxz8 92 6 has have VBZ cord-283202-5fq1wxz8 92 7 been be VBN cord-283202-5fq1wxz8 92 8 shown show VBN cord-283202-5fq1wxz8 92 9 to to TO cord-283202-5fq1wxz8 92 10 alter alter VB cord-283202-5fq1wxz8 92 11 the the DT cord-283202-5fq1wxz8 92 12 eventuality eventuality NN cord-283202-5fq1wxz8 92 13 of of IN cord-283202-5fq1wxz8 92 14 humane humane JJ cord-283202-5fq1wxz8 92 15 euthanasia euthanasia NN cord-283202-5fq1wxz8 92 16 or or CC cord-283202-5fq1wxz8 92 17 death death NN cord-283202-5fq1wxz8 92 18 of of IN cord-283202-5fq1wxz8 92 19 affected affect VBN cord-283202-5fq1wxz8 92 20 cats cat NNS cord-283202-5fq1wxz8 92 21 . . . cord-283202-5fq1wxz8 93 1 Toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 93 2 is be VBZ cord-283202-5fq1wxz8 93 3 caused cause VBN cord-283202-5fq1wxz8 93 4 by by IN cord-283202-5fq1wxz8 93 5 an an DT cord-283202-5fq1wxz8 93 6 obligate obligate JJ cord-283202-5fq1wxz8 93 7 intracellular intracellular JJ cord-283202-5fq1wxz8 93 8 protozoan protozoan NN cord-283202-5fq1wxz8 93 9 parasite parasite NN cord-283202-5fq1wxz8 93 10 , , , cord-283202-5fq1wxz8 93 11 Toxoplasma toxoplasma NN cord-283202-5fq1wxz8 93 12 gondii gondii NN cord-283202-5fq1wxz8 93 13 . . . cord-283202-5fq1wxz8 94 1 The the DT cord-283202-5fq1wxz8 94 2 definitive definitive JJ cord-283202-5fq1wxz8 94 3 hosts host NNS cord-283202-5fq1wxz8 94 4 are be VBP cord-283202-5fq1wxz8 94 5 the the DT cord-283202-5fq1wxz8 94 6 domestic domestic JJ cord-283202-5fq1wxz8 94 7 cat cat NN cord-283202-5fq1wxz8 94 8 and and CC cord-283202-5fq1wxz8 94 9 other other JJ cord-283202-5fq1wxz8 94 10 Felidae Felidae NNP cord-283202-5fq1wxz8 94 11 . . . cord-283202-5fq1wxz8 95 1 Many many JJ cord-283202-5fq1wxz8 95 2 mammals mammal NNS cord-283202-5fq1wxz8 95 3 can can MD cord-283202-5fq1wxz8 95 4 become become VB cord-283202-5fq1wxz8 95 5 infected infect VBN cord-283202-5fq1wxz8 95 6 with with IN cord-283202-5fq1wxz8 95 7 T T NNP cord-283202-5fq1wxz8 95 8 gondii gondii NN cord-283202-5fq1wxz8 95 9 and and CC cord-283202-5fq1wxz8 95 10 serve serve VBP cord-283202-5fq1wxz8 95 11 as as IN cord-283202-5fq1wxz8 95 12 intermediate intermediate JJ cord-283202-5fq1wxz8 95 13 hosts host NNS cord-283202-5fq1wxz8 95 14 ; ; : cord-283202-5fq1wxz8 95 15 however however RB cord-283202-5fq1wxz8 95 16 , , , cord-283202-5fq1wxz8 95 17 fecal fecal JJ cord-283202-5fq1wxz8 95 18 shedding shedding NN cord-283202-5fq1wxz8 95 19 of of IN cord-283202-5fq1wxz8 95 20 infective infective JJ cord-283202-5fq1wxz8 95 21 oocysts oocyst NNS cord-283202-5fq1wxz8 95 22 occurs occur VBZ cord-283202-5fq1wxz8 95 23 only only RB cord-283202-5fq1wxz8 95 24 in in IN cord-283202-5fq1wxz8 95 25 cats cat NNS cord-283202-5fq1wxz8 95 26 . . . cord-283202-5fq1wxz8 96 1 Systemic systemic JJ cord-283202-5fq1wxz8 96 2 and and CC cord-283202-5fq1wxz8 96 3 ocular ocular JJ cord-283202-5fq1wxz8 96 4 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 96 5 have have VBP cord-283202-5fq1wxz8 96 6 been be VBN cord-283202-5fq1wxz8 96 7 well well RB cord-283202-5fq1wxz8 96 8 described describe VBN cord-283202-5fq1wxz8 96 9 in in IN cord-283202-5fq1wxz8 96 10 cats cat NNS cord-283202-5fq1wxz8 96 11 . . . cord-283202-5fq1wxz8 97 1 The the DT cord-283202-5fq1wxz8 97 2 emphasis emphasis NN cord-283202-5fq1wxz8 97 3 in in IN cord-283202-5fq1wxz8 97 4 the the DT cord-283202-5fq1wxz8 97 5 following following JJ cord-283202-5fq1wxz8 97 6 discussion discussion NN cord-283202-5fq1wxz8 97 7 is be VBZ cord-283202-5fq1wxz8 97 8 on on IN cord-283202-5fq1wxz8 97 9 central central JJ cord-283202-5fq1wxz8 97 10 nervous nervous JJ cord-283202-5fq1wxz8 97 11 system system NN cord-283202-5fq1wxz8 97 12 ( ( -LRB- cord-283202-5fq1wxz8 97 13 CNS CNS NNP cord-283202-5fq1wxz8 97 14 ) ) -RRB- cord-283202-5fq1wxz8 97 15 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 97 16 . . . cord-283202-5fq1wxz8 98 1 There there EX cord-283202-5fq1wxz8 98 2 are be VBP cord-283202-5fq1wxz8 98 3 three three CD cord-283202-5fq1wxz8 98 4 methods method NNS cord-283202-5fq1wxz8 98 5 of of IN cord-283202-5fq1wxz8 98 6 transmission transmission NN cord-283202-5fq1wxz8 98 7 of of IN cord-283202-5fq1wxz8 98 8 T T NNP cord-283202-5fq1wxz8 98 9 gondii gondii NN cord-283202-5fq1wxz8 98 10 : : : cord-283202-5fq1wxz8 98 11 fecal fecal JJ cord-283202-5fq1wxz8 98 12 - - HYPH cord-283202-5fq1wxz8 98 13 oral oral JJ cord-283202-5fq1wxz8 98 14 , , , cord-283202-5fq1wxz8 98 15 ingestion ingestion NN cord-283202-5fq1wxz8 98 16 of of IN cord-283202-5fq1wxz8 98 17 tissue tissue NN cord-283202-5fq1wxz8 98 18 cysts cyst NNS cord-283202-5fq1wxz8 98 19 , , , cord-283202-5fq1wxz8 98 20 and and CC cord-283202-5fq1wxz8 98 21 congenital congenital JJ cord-283202-5fq1wxz8 98 22 . . . cord-283202-5fq1wxz8 99 1 Reproduction reproduction NN cord-283202-5fq1wxz8 99 2 of of IN cord-283202-5fq1wxz8 99 3 the the DT cord-283202-5fq1wxz8 99 4 organism organism NN cord-283202-5fq1wxz8 99 5 can can MD cord-283202-5fq1wxz8 99 6 involve involve VB cord-283202-5fq1wxz8 99 7 both both CC cord-283202-5fq1wxz8 99 8 a a DT cord-283202-5fq1wxz8 99 9 sexual sexual JJ cord-283202-5fq1wxz8 99 10 and and CC cord-283202-5fq1wxz8 99 11 asexual asexual JJ cord-283202-5fq1wxz8 99 12 phase phase NN cord-283202-5fq1wxz8 99 13 . . . cord-283202-5fq1wxz8 100 1 The the DT cord-283202-5fq1wxz8 100 2 asexual asexual JJ cord-283202-5fq1wxz8 100 3 phase phase NN cord-283202-5fq1wxz8 100 4 occurs occur VBZ cord-283202-5fq1wxz8 100 5 in in IN cord-283202-5fq1wxz8 100 6 many many JJ cord-283202-5fq1wxz8 100 7 mammals mammal NNS cord-283202-5fq1wxz8 100 8 and and CC cord-283202-5fq1wxz8 100 9 birds bird NNS cord-283202-5fq1wxz8 100 10 , , , cord-283202-5fq1wxz8 100 11 which which WDT cord-283202-5fq1wxz8 100 12 serve serve VBP cord-283202-5fq1wxz8 100 13 as as IN cord-283202-5fq1wxz8 100 14 intermediate intermediate JJ cord-283202-5fq1wxz8 100 15 hosts host NNS cord-283202-5fq1wxz8 100 16 . . . cord-283202-5fq1wxz8 101 1 As as IN cord-283202-5fq1wxz8 101 2 the the DT cord-283202-5fq1wxz8 101 3 definitive definitive JJ cord-283202-5fq1wxz8 101 4 host host NN cord-283202-5fq1wxz8 101 5 , , , cord-283202-5fq1wxz8 101 6 the the DT cord-283202-5fq1wxz8 101 7 sexual sexual JJ cord-283202-5fq1wxz8 101 8 phase phase NN cord-283202-5fq1wxz8 101 9 of of IN cord-283202-5fq1wxz8 101 10 the the DT cord-283202-5fq1wxz8 101 11 life life NN cord-283202-5fq1wxz8 101 12 cycle cycle NN cord-283202-5fq1wxz8 101 13 can can MD cord-283202-5fq1wxz8 101 14 only only RB cord-283202-5fq1wxz8 101 15 occur occur VB cord-283202-5fq1wxz8 101 16 in in IN cord-283202-5fq1wxz8 101 17 cats cat NNS cord-283202-5fq1wxz8 101 18 and and CC cord-283202-5fq1wxz8 101 19 it -PRON- PRP cord-283202-5fq1wxz8 101 20 does do VBZ cord-283202-5fq1wxz8 101 21 so so RB cord-283202-5fq1wxz8 101 22 within within IN cord-283202-5fq1wxz8 101 23 the the DT cord-283202-5fq1wxz8 101 24 intestinal intestinal JJ cord-283202-5fq1wxz8 101 25 tract tract NN cord-283202-5fq1wxz8 101 26 . . . cord-283202-5fq1wxz8 102 1 As as IN cord-283202-5fq1wxz8 102 2 a a DT cord-283202-5fq1wxz8 102 3 result result NN cord-283202-5fq1wxz8 102 4 , , , cord-283202-5fq1wxz8 102 5 unsporulated unsporulated JJ cord-283202-5fq1wxz8 102 6 oocysts oocyst NNS cord-283202-5fq1wxz8 102 7 , , , cord-283202-5fq1wxz8 102 8 which which WDT cord-283202-5fq1wxz8 102 9 are be VBP cord-283202-5fq1wxz8 102 10 non non JJ cord-283202-5fq1wxz8 102 11 - - JJ cord-283202-5fq1wxz8 102 12 infectious infectious JJ cord-283202-5fq1wxz8 102 13 , , , cord-283202-5fq1wxz8 102 14 are be VBP cord-283202-5fq1wxz8 102 15 passed pass VBN cord-283202-5fq1wxz8 102 16 in in IN cord-283202-5fq1wxz8 102 17 the the DT cord-283202-5fq1wxz8 102 18 feces fece NNS cord-283202-5fq1wxz8 102 19 . . . cord-283202-5fq1wxz8 103 1 These these DT cord-283202-5fq1wxz8 103 2 oocysts oocyst NNS cord-283202-5fq1wxz8 103 3 require require VBP cord-283202-5fq1wxz8 103 4 1 1 CD cord-283202-5fq1wxz8 103 5 - - SYM cord-283202-5fq1wxz8 103 6 5 5 CD cord-283202-5fq1wxz8 103 7 days day NNS cord-283202-5fq1wxz8 103 8 for for IN cord-283202-5fq1wxz8 103 9 sporulation sporulation NN cord-283202-5fq1wxz8 103 10 to to TO cord-283202-5fq1wxz8 103 11 occur occur VB cord-283202-5fq1wxz8 103 12 , , , cord-283202-5fq1wxz8 103 13 at at IN cord-283202-5fq1wxz8 103 14 which which WDT cord-283202-5fq1wxz8 103 15 point point NN cord-283202-5fq1wxz8 103 16 they -PRON- PRP cord-283202-5fq1wxz8 103 17 become become VBP cord-283202-5fq1wxz8 103 18 infectious infectious JJ cord-283202-5fq1wxz8 103 19 . . . cord-283202-5fq1wxz8 104 1 Ingestion ingestion NN cord-283202-5fq1wxz8 104 2 of of IN cord-283202-5fq1wxz8 104 3 sporulated sporulate VBN cord-283202-5fq1wxz8 104 4 oocysts oocyst NNS cord-283202-5fq1wxz8 104 5 by by IN cord-283202-5fq1wxz8 104 6 another another DT cord-283202-5fq1wxz8 104 7 cat cat NN cord-283202-5fq1wxz8 104 8 begins begin VBZ cord-283202-5fq1wxz8 104 9 another another DT cord-283202-5fq1wxz8 104 10 cycle cycle NN cord-283202-5fq1wxz8 104 11 . . . cord-283202-5fq1wxz8 105 1 Toxoplasma toxoplasma NN cord-283202-5fq1wxz8 105 2 gondii gondii NNP cord-283202-5fq1wxz8 105 3 also also RB cord-283202-5fq1wxz8 105 4 displays display VBZ cord-283202-5fq1wxz8 105 5 an an DT cord-283202-5fq1wxz8 105 6 extraintestinal extraintestinal JJ cord-283202-5fq1wxz8 105 7 life life NN cord-283202-5fq1wxz8 105 8 cycle cycle NN cord-283202-5fq1wxz8 105 9 . . . cord-283202-5fq1wxz8 106 1 After after IN cord-283202-5fq1wxz8 106 2 infectious infectious JJ cord-283202-5fq1wxz8 106 3 oocysts oocyst NNS cord-283202-5fq1wxz8 106 4 have have VBP cord-283202-5fq1wxz8 106 5 been be VBN cord-283202-5fq1wxz8 106 6 ingested ingest VBN cord-283202-5fq1wxz8 106 7 , , , cord-283202-5fq1wxz8 106 8 the the DT cord-283202-5fq1wxz8 106 9 organism organism NN cord-283202-5fq1wxz8 106 10 is be VBZ cord-283202-5fq1wxz8 106 11 capable capable JJ cord-283202-5fq1wxz8 106 12 of of IN cord-283202-5fq1wxz8 106 13 penetrating penetrate VBG cord-283202-5fq1wxz8 106 14 the the DT cord-283202-5fq1wxz8 106 15 wall wall NN cord-283202-5fq1wxz8 106 16 of of IN cord-283202-5fq1wxz8 106 17 the the DT cord-283202-5fq1wxz8 106 18 intestinal intestinal JJ cord-283202-5fq1wxz8 106 19 tract tract NN cord-283202-5fq1wxz8 106 20 and and CC cord-283202-5fq1wxz8 106 21 disseminating disseminate VBG cord-283202-5fq1wxz8 106 22 to to IN cord-283202-5fq1wxz8 106 23 multiple multiple JJ cord-283202-5fq1wxz8 106 24 organs organ NNS cord-283202-5fq1wxz8 106 25 . . . cord-283202-5fq1wxz8 107 1 Within within IN cord-283202-5fq1wxz8 107 2 these these DT cord-283202-5fq1wxz8 107 3 other other JJ cord-283202-5fq1wxz8 107 4 organs organ NNS cord-283202-5fq1wxz8 107 5 , , , cord-283202-5fq1wxz8 107 6 asexual asexual JJ cord-283202-5fq1wxz8 107 7 reproduction reproduction NN cord-283202-5fq1wxz8 107 8 occurs occur VBZ cord-283202-5fq1wxz8 107 9 , , , cord-283202-5fq1wxz8 107 10 giving give VBG cord-283202-5fq1wxz8 107 11 rise rise NN cord-283202-5fq1wxz8 107 12 to to IN cord-283202-5fq1wxz8 107 13 tissue tissue NN cord-283202-5fq1wxz8 107 14 cysts cyst NNS cord-283202-5fq1wxz8 107 15 -bradyzoites -bradyzoites . cord-283202-5fq1wxz8 108 1 ( ( -LRB- cord-283202-5fq1wxz8 108 2 so so RB cord-283202-5fq1wxz8 108 3 named name VBN cord-283202-5fq1wxz8 108 4 given give VBN cord-283202-5fq1wxz8 108 5 their -PRON- PRP$ cord-283202-5fq1wxz8 108 6 slow slow JJ cord-283202-5fq1wxz8 108 7 replication replication NN cord-283202-5fq1wxz8 108 8 ) ) -RRB- cord-283202-5fq1wxz8 108 9 and and CC cord-283202-5fq1wxz8 108 10 tachyzoites tachyzoites NNP cord-283202-5fq1wxz8 108 11 ( ( -LRB- cord-283202-5fq1wxz8 108 12 in in IN cord-283202-5fq1wxz8 108 13 which which WDT cord-283202-5fq1wxz8 108 14 replication replication NN cord-283202-5fq1wxz8 108 15 is be VBZ cord-283202-5fq1wxz8 108 16 rapid rapid JJ cord-283202-5fq1wxz8 108 17 ) ) -RRB- cord-283202-5fq1wxz8 108 18 . . . cord-283202-5fq1wxz8 109 1 Ingestion ingestion NN cord-283202-5fq1wxz8 109 2 of of IN cord-283202-5fq1wxz8 109 3 bradyzoites bradyzoite NNS cord-283202-5fq1wxz8 109 4 in in IN cord-283202-5fq1wxz8 109 5 tissue tissue NN cord-283202-5fq1wxz8 109 6 is be VBZ cord-283202-5fq1wxz8 109 7 probably probably RB cord-283202-5fq1wxz8 109 8 responsible responsible JJ cord-283202-5fq1wxz8 109 9 for for IN cord-283202-5fq1wxz8 109 10 the the DT cord-283202-5fq1wxz8 109 11 majority majority NN cord-283202-5fq1wxz8 109 12 of of IN cord-283202-5fq1wxz8 109 13 infections infection NNS cord-283202-5fq1wxz8 109 14 . . . cord-283202-5fq1wxz8 110 1 In in IN cord-283202-5fq1wxz8 110 2 cats cat NNS cord-283202-5fq1wxz8 110 3 it -PRON- PRP cord-283202-5fq1wxz8 110 4 can can MD cord-283202-5fq1wxz8 110 5 result result VB cord-283202-5fq1wxz8 110 6 in in IN cord-283202-5fq1wxz8 110 7 intestinal intestinal JJ cord-283202-5fq1wxz8 110 8 replication replication NN cord-283202-5fq1wxz8 110 9 , , , cord-283202-5fq1wxz8 110 10 while while IN cord-283202-5fq1wxz8 110 11 ingestion ingestion NN cord-283202-5fq1wxz8 110 12 of of IN cord-283202-5fq1wxz8 110 13 bradyzoites bradyzoite NNS cord-283202-5fq1wxz8 110 14 by by IN cord-283202-5fq1wxz8 110 15 other other JJ cord-283202-5fq1wxz8 110 16 animals animal NNS cord-283202-5fq1wxz8 110 17 can can MD cord-283202-5fq1wxz8 110 18 only only RB cord-283202-5fq1wxz8 110 19 lead lead VB cord-283202-5fq1wxz8 110 20 to to IN cord-283202-5fq1wxz8 110 21 extraintestinal extraintestinal JJ cord-283202-5fq1wxz8 110 22 infection infection NN cord-283202-5fq1wxz8 110 23 . . . cord-283202-5fq1wxz8 111 1 Ingestion ingestion NN cord-283202-5fq1wxz8 111 2 of of IN cord-283202-5fq1wxz8 111 3 infectious infectious JJ cord-283202-5fq1wxz8 111 4 organism organism NN cord-283202-5fq1wxz8 111 5 during during IN cord-283202-5fq1wxz8 111 6 gestation gestation NN cord-283202-5fq1wxz8 111 7 can can MD cord-283202-5fq1wxz8 111 8 also also RB cord-283202-5fq1wxz8 111 9 lead lead VB cord-283202-5fq1wxz8 111 10 to to IN cord-283202-5fq1wxz8 111 11 congenital congenital JJ cord-283202-5fq1wxz8 111 12 infection infection NN cord-283202-5fq1wxz8 111 13 . . . cord-283202-5fq1wxz8 112 1 37 37 CD cord-283202-5fq1wxz8 112 2 Cysts cyst NNS cord-283202-5fq1wxz8 112 3 that that WDT cord-283202-5fq1wxz8 112 4 form form VBP cord-283202-5fq1wxz8 112 5 as as IN cord-283202-5fq1wxz8 112 6 a a DT cord-283202-5fq1wxz8 112 7 result result NN cord-283202-5fq1wxz8 112 8 of of IN cord-283202-5fq1wxz8 112 9 extraintestinal extraintestinal JJ cord-283202-5fq1wxz8 112 10 infection infection NN cord-283202-5fq1wxz8 112 11 are be VBP cord-283202-5fq1wxz8 112 12 likely likely JJ cord-283202-5fq1wxz8 112 13 to to TO cord-283202-5fq1wxz8 112 14 persist persist VB cord-283202-5fq1wxz8 112 15 for for IN cord-283202-5fq1wxz8 112 16 life life NN cord-283202-5fq1wxz8 112 17 . . . cord-283202-5fq1wxz8 113 1 38 38 CD cord-283202-5fq1wxz8 113 2 , , , cord-283202-5fq1wxz8 113 3 39 39 CD cord-283202-5fq1wxz8 113 4 Encysted Encysted NNP cord-283202-5fq1wxz8 113 5 bradyzoites bradyzoite NNS cord-283202-5fq1wxz8 113 6 are be VBP cord-283202-5fq1wxz8 113 7 the the DT cord-283202-5fq1wxz8 113 8 most most RBS cord-283202-5fq1wxz8 113 9 probable probable JJ cord-283202-5fq1wxz8 113 10 source source NN cord-283202-5fq1wxz8 113 11 of of IN cord-283202-5fq1wxz8 113 12 continual continual JJ cord-283202-5fq1wxz8 113 13 release release NN cord-283202-5fq1wxz8 113 14 of of IN cord-283202-5fq1wxz8 113 15 antigen antigen NN cord-283202-5fq1wxz8 113 16 and and CC cord-283202-5fq1wxz8 113 17 reactivation reactivation NN cord-283202-5fq1wxz8 113 18 of of IN cord-283202-5fq1wxz8 113 19 infection infection NN cord-283202-5fq1wxz8 113 20 . . . cord-283202-5fq1wxz8 114 1 38 38 CD cord-283202-5fq1wxz8 114 2 Reactivation reactivation NN cord-283202-5fq1wxz8 114 3 of of IN cord-283202-5fq1wxz8 114 4 infection infection NN cord-283202-5fq1wxz8 114 5 is be VBZ cord-283202-5fq1wxz8 114 6 thought think VBN cord-283202-5fq1wxz8 114 7 to to TO cord-283202-5fq1wxz8 114 8 occur occur VB cord-283202-5fq1wxz8 114 9 secondarily secondarily RB cord-283202-5fq1wxz8 114 10 to to IN cord-283202-5fq1wxz8 114 11 immunosuppression immunosuppression NN cord-283202-5fq1wxz8 114 12 . . . cord-283202-5fq1wxz8 115 1 Cats cat NNS cord-283202-5fq1wxz8 115 2 infected infect VBN cord-283202-5fq1wxz8 115 3 with with IN cord-283202-5fq1wxz8 115 4 FIV FIV NNP cord-283202-5fq1wxz8 115 5 appear appear VBP cord-283202-5fq1wxz8 115 6 to to TO cord-283202-5fq1wxz8 115 7 be be VB cord-283202-5fq1wxz8 115 8 predisposed predisposed JJ cord-283202-5fq1wxz8 115 9 to to IN cord-283202-5fq1wxz8 115 10 the the DT cord-283202-5fq1wxz8 115 11 development development NN cord-283202-5fq1wxz8 115 12 of of IN cord-283202-5fq1wxz8 115 13 acute acute JJ cord-283202-5fq1wxz8 115 14 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 115 15 . . . cord-283202-5fq1wxz8 116 1 40 40 CD cord-283202-5fq1wxz8 117 1 There there EX cord-283202-5fq1wxz8 117 2 appears appear VBZ cord-283202-5fq1wxz8 117 3 to to TO cord-283202-5fq1wxz8 117 4 be be VB cord-283202-5fq1wxz8 117 5 a a DT cord-283202-5fq1wxz8 117 6 high high JJ cord-283202-5fq1wxz8 117 7 seroprevalence seroprevalence NN cord-283202-5fq1wxz8 117 8 of of IN cord-283202-5fq1wxz8 117 9 T T NNP cord-283202-5fq1wxz8 117 10 gondii gondii NN cord-283202-5fq1wxz8 117 11 infection infection NN cord-283202-5fq1wxz8 117 12 in in IN cord-283202-5fq1wxz8 117 13 cats cat NNS cord-283202-5fq1wxz8 117 14 co co VBD cord-283202-5fq1wxz8 117 15 - - VBD cord-283202-5fq1wxz8 117 16 infected infect VBN cord-283202-5fq1wxz8 117 17 with with IN cord-283202-5fq1wxz8 117 18 FIV FIV NNP cord-283202-5fq1wxz8 117 19 . . . cord-283202-5fq1wxz8 118 1 41 41 CD cord-283202-5fq1wxz8 118 2 , , , cord-283202-5fq1wxz8 118 3 42 42 CD cord-283202-5fq1wxz8 119 1 The the DT cord-283202-5fq1wxz8 119 2 significance significance NN cord-283202-5fq1wxz8 119 3 of of IN cord-283202-5fq1wxz8 119 4 this this DT cord-283202-5fq1wxz8 119 5 relationship relationship NN cord-283202-5fq1wxz8 119 6 is be VBZ cord-283202-5fq1wxz8 119 7 unknown unknown JJ cord-283202-5fq1wxz8 119 8 as as IN cord-283202-5fq1wxz8 119 9 the the DT cord-283202-5fq1wxz8 119 10 seroprevalence seroprevalence NN cord-283202-5fq1wxz8 119 11 of of IN cord-283202-5fq1wxz8 119 12 T T NNP cord-283202-5fq1wxz8 119 13 gondii gondii NN cord-283202-5fq1wxz8 119 14 infection infection NN cord-283202-5fq1wxz8 119 15 in in IN cord-283202-5fq1wxz8 119 16 FIV fiv NN cord-283202-5fq1wxz8 119 17 - - HYPH cord-283202-5fq1wxz8 119 18 infected infect VBN cord-283202-5fq1wxz8 119 19 cats cat NNS cord-283202-5fq1wxz8 119 20 is be VBZ cord-283202-5fq1wxz8 119 21 similar similar JJ cord-283202-5fq1wxz8 119 22 to to IN cord-283202-5fq1wxz8 119 23 that that DT cord-283202-5fq1wxz8 119 24 in in IN cord-283202-5fq1wxz8 119 25 the the DT cord-283202-5fq1wxz8 119 26 general general JJ cord-283202-5fq1wxz8 119 27 population population NN cord-283202-5fq1wxz8 119 28 . . . cord-283202-5fq1wxz8 120 1 39 39 CD cord-283202-5fq1wxz8 120 2 , , , cord-283202-5fq1wxz8 120 3 43 43 CD cord-283202-5fq1wxz8 120 4 Immunosuppression Immunosuppression NNP cord-283202-5fq1wxz8 120 5 as as IN cord-283202-5fq1wxz8 120 6 a a DT cord-283202-5fq1wxz8 120 7 result result NN cord-283202-5fq1wxz8 120 8 of of IN cord-283202-5fq1wxz8 120 9 ciclosporin ciclosporin NN cord-283202-5fq1wxz8 120 10 therapy therapy NN cord-283202-5fq1wxz8 120 11 has have VBZ cord-283202-5fq1wxz8 120 12 also also RB cord-283202-5fq1wxz8 120 13 led lead VBN cord-283202-5fq1wxz8 120 14 to to IN cord-283202-5fq1wxz8 120 15 acute acute JJ cord-283202-5fq1wxz8 120 16 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 120 17 . . . cord-283202-5fq1wxz8 121 1 44 44 CD cord-283202-5fq1wxz8 121 2 , , , cord-283202-5fq1wxz8 121 3 45 45 CD cord-283202-5fq1wxz8 122 1 With with IN cord-283202-5fq1wxz8 122 2 the the DT cord-283202-5fq1wxz8 122 3 availability availability NN cord-283202-5fq1wxz8 122 4 of of IN cord-283202-5fq1wxz8 122 5 renal renal JJ cord-283202-5fq1wxz8 122 6 transplantation transplantation NN cord-283202-5fq1wxz8 122 7 in in IN cord-283202-5fq1wxz8 122 8 cats cat NNS cord-283202-5fq1wxz8 122 9 , , , cord-283202-5fq1wxz8 122 10 the the DT cord-283202-5fq1wxz8 122 11 role role NN cord-283202-5fq1wxz8 122 12 of of IN cord-283202-5fq1wxz8 122 13 immunosuppression immunosuppression NN cord-283202-5fq1wxz8 122 14 in in IN cord-283202-5fq1wxz8 122 15 reactivation reactivation NN cord-283202-5fq1wxz8 122 16 of of IN cord-283202-5fq1wxz8 122 17 infection infection NN cord-283202-5fq1wxz8 122 18 and and CC cord-283202-5fq1wxz8 122 19 the the DT cord-283202-5fq1wxz8 122 20 development development NN cord-283202-5fq1wxz8 122 21 of of IN cord-283202-5fq1wxz8 122 22 clinical clinical JJ cord-283202-5fq1wxz8 122 23 disease disease NN cord-283202-5fq1wxz8 122 24 has have VBZ cord-283202-5fq1wxz8 122 25 gained gain VBN cord-283202-5fq1wxz8 122 26 importance importance NN cord-283202-5fq1wxz8 122 27 . . . cord-283202-5fq1wxz8 123 1 [ [ -LRB- cord-283202-5fq1wxz8 123 2 46 46 CD cord-283202-5fq1wxz8 123 3 ] ] -RRB- cord-283202-5fq1wxz8 123 4 [ [ -LRB- cord-283202-5fq1wxz8 123 5 47 47 CD cord-283202-5fq1wxz8 123 6 ] ] -RRB- cord-283202-5fq1wxz8 124 1 [ [ -LRB- cord-283202-5fq1wxz8 124 2 48 48 CD cord-283202-5fq1wxz8 124 3 ] ] -RRB- cord-283202-5fq1wxz8 125 1 Clinical clinical JJ cord-283202-5fq1wxz8 125 2 signs sign NNS cord-283202-5fq1wxz8 125 3 Clinical clinical JJ cord-283202-5fq1wxz8 125 4 infection infection NN cord-283202-5fq1wxz8 125 5 with with IN cord-283202-5fq1wxz8 125 6 T T NNP cord-283202-5fq1wxz8 125 7 gondii gondii NN cord-283202-5fq1wxz8 125 8 is be VBZ cord-283202-5fq1wxz8 125 9 not not RB cord-283202-5fq1wxz8 125 10 common common JJ cord-283202-5fq1wxz8 125 11 in in IN cord-283202-5fq1wxz8 125 12 cats cat NNS cord-283202-5fq1wxz8 125 13 . . . cord-283202-5fq1wxz8 126 1 Infections infection NNS cord-283202-5fq1wxz8 126 2 can can MD cord-283202-5fq1wxz8 126 3 be be VB cord-283202-5fq1wxz8 126 4 considered consider VBN cord-283202-5fq1wxz8 126 5 acute acute JJ cord-283202-5fq1wxz8 126 6 or or CC cord-283202-5fq1wxz8 126 7 chronic chronic JJ cord-283202-5fq1wxz8 126 8 . . . cord-283202-5fq1wxz8 127 1 49 49 CD cord-283202-5fq1wxz8 127 2 Acute acute JJ cord-283202-5fq1wxz8 127 3 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 127 4 typically typically RB cord-283202-5fq1wxz8 127 5 affects affect VBZ cord-283202-5fq1wxz8 127 6 younger young JJR cord-283202-5fq1wxz8 127 7 cats cat NNS cord-283202-5fq1wxz8 127 8 . . . cord-283202-5fq1wxz8 128 1 The the DT cord-283202-5fq1wxz8 128 2 most most RBS cord-283202-5fq1wxz8 128 3 common common JJ cord-283202-5fq1wxz8 128 4 clinical clinical JJ cord-283202-5fq1wxz8 128 5 signs sign NNS cord-283202-5fq1wxz8 128 6 are be VBP cord-283202-5fq1wxz8 128 7 anorexia anorexia NN cord-283202-5fq1wxz8 128 8 , , , cord-283202-5fq1wxz8 128 9 lethargy lethargy NN cord-283202-5fq1wxz8 128 10 , , , cord-283202-5fq1wxz8 128 11 fever fever NN cord-283202-5fq1wxz8 128 12 , , , cord-283202-5fq1wxz8 128 13 dyspnea dyspnea NN cord-283202-5fq1wxz8 128 14 and and CC cord-283202-5fq1wxz8 128 15 sudden sudden JJ cord-283202-5fq1wxz8 128 16 death death NN cord-283202-5fq1wxz8 128 17 . . . cord-283202-5fq1wxz8 129 1 [ [ -LRB- cord-283202-5fq1wxz8 129 2 49 49 CD cord-283202-5fq1wxz8 129 3 ] ] -RRB- cord-283202-5fq1wxz8 129 4 [ [ -LRB- cord-283202-5fq1wxz8 129 5 50 50 CD cord-283202-5fq1wxz8 129 6 ] ] -RRB- cord-283202-5fq1wxz8 129 7 [ [ -LRB- cord-283202-5fq1wxz8 129 8 51 51 CD cord-283202-5fq1wxz8 129 9 ] ] -RRB- cord-283202-5fq1wxz8 130 1 [ [ -LRB- cord-283202-5fq1wxz8 130 2 52 52 CD cord-283202-5fq1wxz8 130 3 ] ] -RRB- cord-283202-5fq1wxz8 131 1 Chronic chronic JJ cord-283202-5fq1wxz8 131 2 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 131 3 typically typically RB cord-283202-5fq1wxz8 131 4 affects affect VBZ cord-283202-5fq1wxz8 131 5 older old JJR cord-283202-5fq1wxz8 131 6 cats cat NNS cord-283202-5fq1wxz8 131 7 and and CC cord-283202-5fq1wxz8 131 8 manifests manifest VBZ cord-283202-5fq1wxz8 131 9 over over IN cord-283202-5fq1wxz8 131 10 weeks week NNS cord-283202-5fq1wxz8 131 11 to to IN cord-283202-5fq1wxz8 131 12 months month NNS cord-283202-5fq1wxz8 131 13 . . . cord-283202-5fq1wxz8 132 1 Signs sign NNS cord-283202-5fq1wxz8 132 2 are be VBP cord-283202-5fq1wxz8 132 3 similar similar JJ cord-283202-5fq1wxz8 132 4 to to IN cord-283202-5fq1wxz8 132 5 acute acute JJ cord-283202-5fq1wxz8 132 6 infection infection NN cord-283202-5fq1wxz8 132 7 and and CC cord-283202-5fq1wxz8 132 8 may may MD cord-283202-5fq1wxz8 132 9 include include VB cord-283202-5fq1wxz8 132 10 vomiting vomit VBG cord-283202-5fq1wxz8 132 11 , , , cord-283202-5fq1wxz8 132 12 diarrhea diarrhea NN cord-283202-5fq1wxz8 132 13 , , , cord-283202-5fq1wxz8 132 14 anorexia anorexia NN cord-283202-5fq1wxz8 132 15 , , , cord-283202-5fq1wxz8 132 16 weight weight NN cord-283202-5fq1wxz8 132 17 loss loss NN cord-283202-5fq1wxz8 132 18 , , , cord-283202-5fq1wxz8 132 19 fever fever NN cord-283202-5fq1wxz8 132 20 and and CC cord-283202-5fq1wxz8 132 21 icterus icterus NN cord-283202-5fq1wxz8 132 22 . . . cord-283202-5fq1wxz8 133 1 42 42 CD cord-283202-5fq1wxz8 133 2 , , , cord-283202-5fq1wxz8 133 3 [ [ -LRB- cord-283202-5fq1wxz8 133 4 49 49 CD cord-283202-5fq1wxz8 133 5 ] ] -RRB- cord-283202-5fq1wxz8 133 6 [ [ -LRB- cord-283202-5fq1wxz8 133 7 50 50 CD cord-283202-5fq1wxz8 133 8 ] ] -RRB- cord-283202-5fq1wxz8 134 1 [ [ -LRB- cord-283202-5fq1wxz8 134 2 51 51 CD cord-283202-5fq1wxz8 134 3 ] ] -RRB- cord-283202-5fq1wxz8 134 4 _SP cord-283202-5fq1wxz8 135 1 With with IN cord-283202-5fq1wxz8 135 2 the the DT cord-283202-5fq1wxz8 135 3 exception exception NN cord-283202-5fq1wxz8 135 4 of of IN cord-283202-5fq1wxz8 135 5 finding find VBG cord-283202-5fq1wxz8 135 6 T t NN cord-283202-5fq1wxz8 135 7 gondii gondii NN cord-283202-5fq1wxz8 135 8 in in IN cord-283202-5fq1wxz8 135 9 tissue tissue NN cord-283202-5fq1wxz8 135 10 , , , cord-283202-5fq1wxz8 135 11 no no DT cord-283202-5fq1wxz8 135 12 single single JJ cord-283202-5fq1wxz8 135 13 test test NN cord-283202-5fq1wxz8 135 14 provides provide VBZ cord-283202-5fq1wxz8 135 15 a a DT cord-283202-5fq1wxz8 135 16 definitive definitive JJ cord-283202-5fq1wxz8 135 17 diagnosis diagnosis NN cord-283202-5fq1wxz8 135 18 . . . cord-283202-5fq1wxz8 136 1 Serology serology NN cord-283202-5fq1wxz8 136 2 for for IN cord-283202-5fq1wxz8 136 3 the the DT cord-283202-5fq1wxz8 136 4 detection detection NN cord-283202-5fq1wxz8 136 5 of of IN cord-283202-5fq1wxz8 136 6 IgG IgG NNP cord-283202-5fq1wxz8 136 7 and and CC cord-283202-5fq1wxz8 136 8 IgM IgM NNP cord-283202-5fq1wxz8 136 9 anti anti NNP cord-283202-5fq1wxz8 136 10 - - NNP cord-283202-5fq1wxz8 136 11 T t JJ cord-283202-5fq1wxz8 136 12 gondii gondii NN cord-283202-5fq1wxz8 136 13 antibodies antibody NNS cord-283202-5fq1wxz8 136 14 is be VBZ cord-283202-5fq1wxz8 136 15 widely widely RB cord-283202-5fq1wxz8 136 16 used use VBN cord-283202-5fq1wxz8 136 17 . . . cord-283202-5fq1wxz8 137 1 61 61 CD cord-283202-5fq1wxz8 138 1 After after IN cord-283202-5fq1wxz8 138 2 experimental experimental JJ cord-283202-5fq1wxz8 138 3 inoculation inoculation NN cord-283202-5fq1wxz8 138 4 , , , cord-283202-5fq1wxz8 138 5 an an DT cord-283202-5fq1wxz8 138 6 IgM IgM NNP cord-283202-5fq1wxz8 138 7 response response NN cord-283202-5fq1wxz8 138 8 is be VBZ cord-283202-5fq1wxz8 138 9 detected detect VBN cord-283202-5fq1wxz8 138 10 in in IN cord-283202-5fq1wxz8 138 11 1 1 CD cord-283202-5fq1wxz8 138 12 - - SYM cord-283202-5fq1wxz8 138 13 3 3 CD cord-283202-5fq1wxz8 138 14 weeks week NNS cord-283202-5fq1wxz8 138 15 and and CC cord-283202-5fq1wxz8 138 16 an an DT cord-283202-5fq1wxz8 138 17 IgG igg NN cord-283202-5fq1wxz8 138 18 response response NN cord-283202-5fq1wxz8 138 19 in in IN cord-283202-5fq1wxz8 138 20 2 2 CD cord-283202-5fq1wxz8 138 21 - - SYM cord-283202-5fq1wxz8 138 22 4 4 CD cord-283202-5fq1wxz8 138 23 weeks week NNS cord-283202-5fq1wxz8 138 24 . . . cord-283202-5fq1wxz8 139 1 Immunoglobulin Immunoglobulin NNP cord-283202-5fq1wxz8 139 2 M M NNP cord-283202-5fq1wxz8 139 3 responses response NNS cord-283202-5fq1wxz8 139 4 peak peak VBP cord-283202-5fq1wxz8 139 5 within within IN cord-283202-5fq1wxz8 139 6 3 3 CD cord-283202-5fq1wxz8 139 7 weeks week NNS cord-283202-5fq1wxz8 139 8 and and CC cord-283202-5fq1wxz8 139 9 persist persist VB cord-283202-5fq1wxz8 139 10 for for IN cord-283202-5fq1wxz8 139 11 3 3 CD cord-283202-5fq1wxz8 139 12 - - SYM cord-283202-5fq1wxz8 139 13 16 16 CD cord-283202-5fq1wxz8 139 14 weeks week NNS cord-283202-5fq1wxz8 139 15 . . . cord-283202-5fq1wxz8 140 1 In in IN cord-283202-5fq1wxz8 140 2 cats cat NNS cord-283202-5fq1wxz8 140 3 co co VBP cord-283202-5fq1wxz8 140 4 - - VBD cord-283202-5fq1wxz8 140 5 infected infect VBN cord-283202-5fq1wxz8 140 6 with with IN cord-283202-5fq1wxz8 140 7 FIV FIV NNP cord-283202-5fq1wxz8 140 8 , , , cord-283202-5fq1wxz8 140 9 there there EX cord-283202-5fq1wxz8 140 10 is be VBZ cord-283202-5fq1wxz8 140 11 a a DT cord-283202-5fq1wxz8 140 12 delayed delay VBN cord-283202-5fq1wxz8 140 13 conversion conversion NN cord-283202-5fq1wxz8 140 14 from from IN cord-283202-5fq1wxz8 140 15 an an DT cord-283202-5fq1wxz8 140 16 IgM igm NN cord-283202-5fq1wxz8 140 17 to to IN cord-283202-5fq1wxz8 140 18 an an DT cord-283202-5fq1wxz8 140 19 IgG igg NN cord-283202-5fq1wxz8 140 20 response response NN cord-283202-5fq1wxz8 140 21 . . . cord-283202-5fq1wxz8 141 1 62 62 CD cord-283202-5fq1wxz8 142 1 Unfortunately unfortunately RB cord-283202-5fq1wxz8 142 2 , , , cord-283202-5fq1wxz8 142 3 an an DT cord-283202-5fq1wxz8 142 4 IgM IgM NNP cord-283202-5fq1wxz8 142 5 response response NN cord-283202-5fq1wxz8 142 6 does do VBZ cord-283202-5fq1wxz8 142 7 not not RB cord-283202-5fq1wxz8 142 8 necessarily necessarily RB cord-283202-5fq1wxz8 142 9 correlate correlate VB cord-283202-5fq1wxz8 142 10 with with IN cord-283202-5fq1wxz8 142 11 active active JJ cord-283202-5fq1wxz8 142 12 disease disease NN cord-283202-5fq1wxz8 142 13 as as IN cord-283202-5fq1wxz8 142 14 occasionally occasionally RB cord-283202-5fq1wxz8 142 15 IgM IgM NNP cord-283202-5fq1wxz8 142 16 responses response NNS cord-283202-5fq1wxz8 142 17 can can MD cord-283202-5fq1wxz8 142 18 be be VB cord-283202-5fq1wxz8 142 19 detected detect VBN cord-283202-5fq1wxz8 142 20 in in IN cord-283202-5fq1wxz8 142 21 clinically clinically RB cord-283202-5fq1wxz8 142 22 normal normal JJ cord-283202-5fq1wxz8 142 23 cats cat NNS cord-283202-5fq1wxz8 142 24 with with IN cord-283202-5fq1wxz8 142 25 chronic chronic JJ cord-283202-5fq1wxz8 142 26 infection infection NN cord-283202-5fq1wxz8 142 27 . . . cord-283202-5fq1wxz8 143 1 Likewise likewise RB cord-283202-5fq1wxz8 143 2 , , , cord-283202-5fq1wxz8 143 3 a a DT cord-283202-5fq1wxz8 143 4 single single JJ cord-283202-5fq1wxz8 143 5 high high JJ cord-283202-5fq1wxz8 143 6 IgG igg NN cord-283202-5fq1wxz8 143 7 response response NN cord-283202-5fq1wxz8 143 8 does do VBZ cord-283202-5fq1wxz8 143 9 not not RB cord-283202-5fq1wxz8 143 10 predict predict VB cord-283202-5fq1wxz8 143 11 active active JJ cord-283202-5fq1wxz8 143 12 disease disease NN cord-283202-5fq1wxz8 143 13 , , , cord-283202-5fq1wxz8 143 14 as as IN cord-283202-5fq1wxz8 143 15 IgG igg NN cord-283202-5fq1wxz8 143 16 responses response NNS cord-283202-5fq1wxz8 143 17 can can MD cord-283202-5fq1wxz8 143 18 last last VB cord-283202-5fq1wxz8 143 19 up up IN cord-283202-5fq1wxz8 143 20 to to TO cord-283202-5fq1wxz8 143 21 6 6 CD cord-283202-5fq1wxz8 143 22 years year NNS cord-283202-5fq1wxz8 143 23 . . . cord-283202-5fq1wxz8 144 1 63 63 CD cord-283202-5fq1wxz8 145 1 A a DT cord-283202-5fq1wxz8 145 2 rising rise VBG cord-283202-5fq1wxz8 145 3 titer titer NN cord-283202-5fq1wxz8 145 4 is be VBZ cord-283202-5fq1wxz8 145 5 strongly strongly RB cord-283202-5fq1wxz8 145 6 suggestive suggestive JJ cord-283202-5fq1wxz8 145 7 of of IN cord-283202-5fq1wxz8 145 8 active active JJ cord-283202-5fq1wxz8 145 9 disease disease NN cord-283202-5fq1wxz8 145 10 , , , cord-283202-5fq1wxz8 145 11 however however RB cord-283202-5fq1wxz8 145 12 , , , cord-283202-5fq1wxz8 145 13 and and CC cord-283202-5fq1wxz8 145 14 maximal maximal JJ cord-283202-5fq1wxz8 145 15 titers titer NNS cord-283202-5fq1wxz8 145 16 are be VBP cord-283202-5fq1wxz8 145 17 reached reach VBN cord-283202-5fq1wxz8 145 18 within within IN cord-283202-5fq1wxz8 145 19 2 2 CD cord-283202-5fq1wxz8 145 20 - - SYM cord-283202-5fq1wxz8 145 21 3 3 CD cord-283202-5fq1wxz8 145 22 weeks week NNS cord-283202-5fq1wxz8 145 23 . . . cord-283202-5fq1wxz8 146 1 63 63 CD cord-283202-5fq1wxz8 147 1 In in IN cord-283202-5fq1wxz8 147 2 practice practice NN cord-283202-5fq1wxz8 147 3 , , , cord-283202-5fq1wxz8 147 4 given give VBN cord-283202-5fq1wxz8 147 5 the the DT cord-283202-5fq1wxz8 147 6 insidious insidious JJ cord-283202-5fq1wxz8 147 7 nature nature NN cord-283202-5fq1wxz8 147 8 of of IN cord-283202-5fq1wxz8 147 9 the the DT cord-283202-5fq1wxz8 147 10 disease disease NN cord-283202-5fq1wxz8 147 11 many many JJ cord-283202-5fq1wxz8 147 12 cats cat NNS cord-283202-5fq1wxz8 147 13 have have VBP cord-283202-5fq1wxz8 147 14 reached reach VBN cord-283202-5fq1wxz8 147 15 maximal maximal JJ cord-283202-5fq1wxz8 147 16 immune immune JJ cord-283202-5fq1wxz8 147 17 responses response NNS cord-283202-5fq1wxz8 147 18 by by IN cord-283202-5fq1wxz8 147 19 the the DT cord-283202-5fq1wxz8 147 20 time time NN cord-283202-5fq1wxz8 147 21 they -PRON- PRP cord-283202-5fq1wxz8 147 22 are be VBP cord-283202-5fq1wxz8 147 23 examined examine VBN cord-283202-5fq1wxz8 147 24 by by IN cord-283202-5fq1wxz8 147 25 a a DT cord-283202-5fq1wxz8 147 26 veterinarian veterinarian NN cord-283202-5fq1wxz8 147 27 , , , cord-283202-5fq1wxz8 147 28 making make VBG cord-283202-5fq1wxz8 147 29 documentation documentation NN cord-283202-5fq1wxz8 147 30 of of IN cord-283202-5fq1wxz8 147 31 a a DT cord-283202-5fq1wxz8 147 32 rising rise VBG cord-283202-5fq1wxz8 147 33 titer titer NN cord-283202-5fq1wxz8 147 34 difficult difficult JJ cord-283202-5fq1wxz8 147 35 . . . cord-283202-5fq1wxz8 148 1 61 61 CD cord-283202-5fq1wxz8 149 1 Theoretically theoretically RB cord-283202-5fq1wxz8 149 2 , , , cord-283202-5fq1wxz8 149 3 identification identification NN cord-283202-5fq1wxz8 149 4 of of IN cord-283202-5fq1wxz8 149 5 an an DT cord-283202-5fq1wxz8 149 6 immune immune JJ cord-283202-5fq1wxz8 149 7 response response NN cord-283202-5fq1wxz8 149 8 in in IN cord-283202-5fq1wxz8 149 9 the the DT cord-283202-5fq1wxz8 149 10 CNS CNS NNP cord-283202-5fq1wxz8 149 11 , , , cord-283202-5fq1wxz8 149 12 an an DT cord-283202-5fq1wxz8 149 13 immunoprivileged immunoprivilege VBN cord-283202-5fq1wxz8 149 14 site site NN cord-283202-5fq1wxz8 149 15 , , , cord-283202-5fq1wxz8 149 16 would would MD cord-283202-5fq1wxz8 149 17 suggest suggest VB cord-283202-5fq1wxz8 149 18 infection infection NN cord-283202-5fq1wxz8 149 19 . . . cord-283202-5fq1wxz8 150 1 However however RB cord-283202-5fq1wxz8 150 2 , , , cord-283202-5fq1wxz8 150 3 immunoglobulins immunoglobulin NNS cord-283202-5fq1wxz8 150 4 may may MD cord-283202-5fq1wxz8 150 5 extravasate extravasate VB cord-283202-5fq1wxz8 150 6 from from IN cord-283202-5fq1wxz8 150 7 the the DT cord-283202-5fq1wxz8 150 8 blood blood NN cord-283202-5fq1wxz8 150 9 into into IN cord-283202-5fq1wxz8 150 10 the the DT cord-283202-5fq1wxz8 150 11 CSF CSF NNP cord-283202-5fq1wxz8 150 12 in in IN cord-283202-5fq1wxz8 150 13 other other JJ cord-283202-5fq1wxz8 150 14 inflammatory inflammatory JJ cord-283202-5fq1wxz8 150 15 diseases disease NNS cord-283202-5fq1wxz8 150 16 that that WDT cord-283202-5fq1wxz8 150 17 disrupt disrupt VBP cord-283202-5fq1wxz8 150 18 the the DT cord-283202-5fq1wxz8 150 19 blood blood NN cord-283202-5fq1wxz8 150 20 - - HYPH cord-283202-5fq1wxz8 150 21 brain brain NN cord-283202-5fq1wxz8 150 22 barrier barrier NN cord-283202-5fq1wxz8 150 23 . . . cord-283202-5fq1wxz8 151 1 Defining define VBG cord-283202-5fq1wxz8 151 2 a a DT cord-283202-5fq1wxz8 151 3 ratio ratio NN cord-283202-5fq1wxz8 151 4 between between IN cord-283202-5fq1wxz8 151 5 serum serum NN cord-283202-5fq1wxz8 151 6 and and CC cord-283202-5fq1wxz8 151 7 CSF CSF NNP cord-283202-5fq1wxz8 151 8 IgG igg NN cord-283202-5fq1wxz8 151 9 responses response NNS cord-283202-5fq1wxz8 151 10 may may MD cord-283202-5fq1wxz8 151 11 help help VB cord-283202-5fq1wxz8 151 12 eliminate eliminate VB cord-283202-5fq1wxz8 151 13 the the DT cord-283202-5fq1wxz8 151 14 possibility possibility NN cord-283202-5fq1wxz8 151 15 of of IN cord-283202-5fq1wxz8 151 16 passive passive JJ cord-283202-5fq1wxz8 151 17 cross cross NN cord-283202-5fq1wxz8 151 18 over over IN cord-283202-5fq1wxz8 151 19 of of IN cord-283202-5fq1wxz8 151 20 antibodies antibody NNS cord-283202-5fq1wxz8 151 21 secondary secondary JJ cord-283202-5fq1wxz8 151 22 to to IN cord-283202-5fq1wxz8 151 23 another another DT cord-283202-5fq1wxz8 151 24 disease disease NN cord-283202-5fq1wxz8 151 25 that that WDT cord-283202-5fq1wxz8 151 26 compromises compromise VBZ cord-283202-5fq1wxz8 151 27 the the DT cord-283202-5fq1wxz8 151 28 integrity integrity NN cord-283202-5fq1wxz8 151 29 of of IN cord-283202-5fq1wxz8 151 30 the the DT cord-283202-5fq1wxz8 151 31 blood blood NN cord-283202-5fq1wxz8 151 32 - - HYPH cord-283202-5fq1wxz8 151 33 brain brain NN cord-283202-5fq1wxz8 151 34 barrier barrier NN cord-283202-5fq1wxz8 151 35 . . . cord-283202-5fq1wxz8 152 1 A a DT cord-283202-5fq1wxz8 152 2 serum serum NN cord-283202-5fq1wxz8 152 3 : : : cord-283202-5fq1wxz8 153 1 CSF CSF NNP cord-283202-5fq1wxz8 153 2 IgG igg NN cord-283202-5fq1wxz8 153 3 response response NN cord-283202-5fq1wxz8 153 4 > > XX cord-283202-5fq1wxz8 154 1 1 1 CD cord-283202-5fq1wxz8 154 2 suggests suggest VBZ cord-283202-5fq1wxz8 154 3 local local JJ cord-283202-5fq1wxz8 154 4 CNS CNS NNP cord-283202-5fq1wxz8 154 5 production production NN cord-283202-5fq1wxz8 154 6 of of IN cord-283202-5fq1wxz8 154 7 immunoglobulin immunoglobulin NN cord-283202-5fq1wxz8 154 8 . . . cord-283202-5fq1wxz8 155 1 In in IN cord-283202-5fq1wxz8 155 2 experimental experimental JJ cord-283202-5fq1wxz8 155 3 oral oral JJ cord-283202-5fq1wxz8 155 4 inoculation inoculation NN cord-283202-5fq1wxz8 155 5 , , , cord-283202-5fq1wxz8 155 6 cats cat NNS cord-283202-5fq1wxz8 155 7 remain remain VBP cord-283202-5fq1wxz8 155 8 clinically clinically RB cord-283202-5fq1wxz8 155 9 normal normal JJ cord-283202-5fq1wxz8 155 10 yet yet CC cord-283202-5fq1wxz8 155 11 develop develop VBP cord-283202-5fq1wxz8 155 12 a a DT cord-283202-5fq1wxz8 155 13 detectable detectable JJ cord-283202-5fq1wxz8 155 14 IgG igg NN cord-283202-5fq1wxz8 155 15 response response NN cord-283202-5fq1wxz8 155 16 in in IN cord-283202-5fq1wxz8 155 17 the the DT cord-283202-5fq1wxz8 155 18 CSF CSF NNP cord-283202-5fq1wxz8 155 19 4 4 CD cord-283202-5fq1wxz8 155 20 - - SYM cord-283202-5fq1wxz8 155 21 12 12 CD cord-283202-5fq1wxz8 155 22 weeks week NNS cord-283202-5fq1wxz8 155 23 post post NN cord-283202-5fq1wxz8 155 24 inoculation inoculation NN cord-283202-5fq1wxz8 155 25 and and CC cord-283202-5fq1wxz8 155 26 again again RB cord-283202-5fq1wxz8 155 27 8 8 CD cord-283202-5fq1wxz8 155 28 - - SYM cord-283202-5fq1wxz8 155 29 16 16 CD cord-283202-5fq1wxz8 155 30 weeks week NNS cord-283202-5fq1wxz8 155 31 after after IN cord-283202-5fq1wxz8 155 32 secondary secondary JJ cord-283202-5fq1wxz8 155 33 exposure exposure NN cord-283202-5fq1wxz8 155 34 . . . cord-283202-5fq1wxz8 156 1 64 64 CD cord-283202-5fq1wxz8 157 1 Importantly importantly RB cord-283202-5fq1wxz8 157 2 , , , cord-283202-5fq1wxz8 157 3 an an DT cord-283202-5fq1wxz8 157 4 IgG igg NN cord-283202-5fq1wxz8 157 5 response response NN cord-283202-5fq1wxz8 157 6 in in IN cord-283202-5fq1wxz8 157 7 the the DT cord-283202-5fq1wxz8 157 8 CSF CSF NNP cord-283202-5fq1wxz8 157 9 can can MD cord-283202-5fq1wxz8 157 10 occur occur VB cord-283202-5fq1wxz8 157 11 after after IN cord-283202-5fq1wxz8 157 12 exposure exposure NN cord-283202-5fq1wxz8 157 13 to to IN cord-283202-5fq1wxz8 157 14 killed kill VBN cord-283202-5fq1wxz8 157 15 tachyzoites tachyzoites NNP cord-283202-5fq1wxz8 157 16 in in IN cord-283202-5fq1wxz8 157 17 previously previously RB cord-283202-5fq1wxz8 157 18 infected infect VBN cord-283202-5fq1wxz8 157 19 cats cat NNS cord-283202-5fq1wxz8 157 20 . . . cord-283202-5fq1wxz8 158 1 65 65 CD cord-283202-5fq1wxz8 159 1 Therefore therefore RB cord-283202-5fq1wxz8 159 2 , , , cord-283202-5fq1wxz8 159 3 observation observation NN cord-283202-5fq1wxz8 159 4 of of IN cord-283202-5fq1wxz8 159 5 an an DT cord-283202-5fq1wxz8 159 6 IgG igg NN cord-283202-5fq1wxz8 159 7 response response NN cord-283202-5fq1wxz8 159 8 in in IN cord-283202-5fq1wxz8 159 9 CSF CSF NNP cord-283202-5fq1wxz8 159 10 does do VBZ cord-283202-5fq1wxz8 159 11 not not RB cord-283202-5fq1wxz8 159 12 necessarily necessarily RB cord-283202-5fq1wxz8 159 13 document document VB cord-283202-5fq1wxz8 159 14 infection infection NN cord-283202-5fq1wxz8 159 15 . . . cord-283202-5fq1wxz8 160 1 65 65 CD cord-283202-5fq1wxz8 160 2 Experimental experimental JJ cord-283202-5fq1wxz8 160 3 inoculation inoculation NN cord-283202-5fq1wxz8 160 4 does do VBZ cord-283202-5fq1wxz8 160 5 not not RB cord-283202-5fq1wxz8 160 6 result result VB cord-283202-5fq1wxz8 160 7 in in IN cord-283202-5fq1wxz8 160 8 an an DT cord-283202-5fq1wxz8 160 9 IgM igm NN cord-283202-5fq1wxz8 160 10 response response NN cord-283202-5fq1wxz8 160 11 in in IN cord-283202-5fq1wxz8 160 12 the the DT cord-283202-5fq1wxz8 160 13 CSF CSF NNP cord-283202-5fq1wxz8 160 14 . . . cord-283202-5fq1wxz8 161 1 64 64 CD cord-283202-5fq1wxz8 162 1 Potentially potentially RB cord-283202-5fq1wxz8 162 2 , , , cord-283202-5fq1wxz8 162 3 therefore therefore RB cord-283202-5fq1wxz8 162 4 , , , cord-283202-5fq1wxz8 162 5 detection detection NN cord-283202-5fq1wxz8 162 6 of of IN cord-283202-5fq1wxz8 162 7 an an DT cord-283202-5fq1wxz8 162 8 IgM igm NN cord-283202-5fq1wxz8 162 9 response response NN cord-283202-5fq1wxz8 162 10 in in IN cord-283202-5fq1wxz8 162 11 the the DT cord-283202-5fq1wxz8 162 12 CSF CSF NNP cord-283202-5fq1wxz8 162 13 may may MD cord-283202-5fq1wxz8 162 14 be be VB cord-283202-5fq1wxz8 162 15 indicative indicative JJ cord-283202-5fq1wxz8 162 16 of of IN cord-283202-5fq1wxz8 162 17 active active JJ cord-283202-5fq1wxz8 162 18 disease disease NN cord-283202-5fq1wxz8 162 19 , , , cord-283202-5fq1wxz8 162 20 but but CC cord-283202-5fq1wxz8 162 21 this this DT cord-283202-5fq1wxz8 162 22 is be VBZ cord-283202-5fq1wxz8 162 23 yet yet RB cord-283202-5fq1wxz8 162 24 to to TO cord-283202-5fq1wxz8 162 25 be be VB cord-283202-5fq1wxz8 162 26 confirmed confirm VBN cord-283202-5fq1wxz8 162 27 . . . cord-283202-5fq1wxz8 163 1 Clinical clinical JJ cord-283202-5fq1wxz8 163 2 signs sign NNS cord-283202-5fq1wxz8 163 3 reflecting reflect VBG cord-283202-5fq1wxz8 163 4 organ organ NN cord-283202-5fq1wxz8 163 5 involvement involvement NN cord-283202-5fq1wxz8 163 6 include include VBP cord-283202-5fq1wxz8 163 7 lymphadenopathy lymphadenopathy JJ cord-283202-5fq1wxz8 163 8 , , , cord-283202-5fq1wxz8 163 9 myocardial myocardial JJ cord-283202-5fq1wxz8 163 10 disease disease NN cord-283202-5fq1wxz8 163 11 , , , cord-283202-5fq1wxz8 163 12 pancreatitis pancreatitis NN cord-283202-5fq1wxz8 163 13 , , , cord-283202-5fq1wxz8 163 14 hepatitis hepatitis NN cord-283202-5fq1wxz8 163 15 , , , cord-283202-5fq1wxz8 163 16 anterior anterior NNP cord-283202-5fq1wxz8 163 17 uveitis uveitis NN cord-283202-5fq1wxz8 163 18 and and CC cord-283202-5fq1wxz8 163 19 chorioretinitis chorioretinitis NNP cord-283202-5fq1wxz8 163 20 . . . cord-283202-5fq1wxz8 164 1 41 41 CD cord-283202-5fq1wxz8 164 2 , , , cord-283202-5fq1wxz8 164 3 42 42 CD cord-283202-5fq1wxz8 164 4 , , , cord-283202-5fq1wxz8 164 5 [ [ -LRB- cord-283202-5fq1wxz8 164 6 49 49 CD cord-283202-5fq1wxz8 164 7 ] ] -RRB- cord-283202-5fq1wxz8 164 8 [ [ -LRB- cord-283202-5fq1wxz8 164 9 50 50 CD cord-283202-5fq1wxz8 164 10 ] ] -RRB- cord-283202-5fq1wxz8 165 1 [ [ -LRB- cord-283202-5fq1wxz8 165 2 51 51 CD cord-283202-5fq1wxz8 165 3 ] ] -RRB- cord-283202-5fq1wxz8 165 4 53 53 CD cord-283202-5fq1wxz8 165 5 , , , cord-283202-5fq1wxz8 165 6 54 54 CD cord-283202-5fq1wxz8 165 7 _SP cord-283202-5fq1wxz8 166 1 The the DT cord-283202-5fq1wxz8 166 2 diagnosis diagnosis NN cord-283202-5fq1wxz8 166 3 of of IN cord-283202-5fq1wxz8 166 4 clinical clinical JJ cord-283202-5fq1wxz8 166 5 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 166 6 can can MD cord-283202-5fq1wxz8 166 7 be be VB cord-283202-5fq1wxz8 166 8 challenging challenging JJ cord-283202-5fq1wxz8 166 9 . . . cord-283202-5fq1wxz8 167 1 Hematologic Hematologic NNP cord-283202-5fq1wxz8 167 2 findings finding NNS cord-283202-5fq1wxz8 167 3 are be VBP cord-283202-5fq1wxz8 167 4 nonspecific nonspecific JJ cord-283202-5fq1wxz8 167 5 , , , cord-283202-5fq1wxz8 167 6 often often RB cord-283202-5fq1wxz8 167 7 consisting consist VBG cord-283202-5fq1wxz8 167 8 of of IN cord-283202-5fq1wxz8 167 9 non non JJ cord-283202-5fq1wxz8 167 10 - - JJ cord-283202-5fq1wxz8 167 11 regenerative regenerative JJ cord-283202-5fq1wxz8 167 12 anemia anemia NN cord-283202-5fq1wxz8 167 13 , , , cord-283202-5fq1wxz8 167 14 neutrophilic neutrophilic NNP cord-283202-5fq1wxz8 167 15 leukocytosis leukocytosis NNP cord-283202-5fq1wxz8 167 16 , , , cord-283202-5fq1wxz8 167 17 lymphocytosis lymphocytosis NNP cord-283202-5fq1wxz8 167 18 and and CC cord-283202-5fq1wxz8 167 19 monocytosis monocytosis NNP cord-283202-5fq1wxz8 167 20 . . . cord-283202-5fq1wxz8 168 1 41 41 CD cord-283202-5fq1wxz8 168 2 , , , cord-283202-5fq1wxz8 168 3 42 42 CD cord-283202-5fq1wxz8 168 4 , , , cord-283202-5fq1wxz8 168 5 50 50 CD cord-283202-5fq1wxz8 168 6 Biochemical biochemical JJ cord-283202-5fq1wxz8 168 7 abnormalities abnormality NNS cord-283202-5fq1wxz8 168 8 generally generally RB cord-283202-5fq1wxz8 168 9 reflect reflect VBP cord-283202-5fq1wxz8 168 10 organ organ NN cord-283202-5fq1wxz8 168 11 involvement involvement NN cord-283202-5fq1wxz8 168 12 and and CC cord-283202-5fq1wxz8 168 13 include include VBP cord-283202-5fq1wxz8 168 14 azotemia azotemia NN cord-283202-5fq1wxz8 168 15 , , , cord-283202-5fq1wxz8 168 16 elevation elevation NN cord-283202-5fq1wxz8 168 17 in in IN cord-283202-5fq1wxz8 168 18 liver liver NN cord-283202-5fq1wxz8 168 19 enzymes enzyme NNS cord-283202-5fq1wxz8 168 20 , , , cord-283202-5fq1wxz8 168 21 hyperbilirubinemia hyperbilirubinemia NN cord-283202-5fq1wxz8 168 22 and and CC cord-283202-5fq1wxz8 168 23 hyperproteinemia hyperproteinemia NN cord-283202-5fq1wxz8 168 24 . . . cord-283202-5fq1wxz8 169 1 41 41 CD cord-283202-5fq1wxz8 169 2 , , , cord-283202-5fq1wxz8 169 3 42 42 CD cord-283202-5fq1wxz8 169 4 , , , cord-283202-5fq1wxz8 169 5 50 50 CD cord-283202-5fq1wxz8 169 6 Thoracic thoracic JJ cord-283202-5fq1wxz8 169 7 radiographs radiograph NNS cord-283202-5fq1wxz8 169 8 may may MD cord-283202-5fq1wxz8 169 9 show show VB cord-283202-5fq1wxz8 169 10 a a DT cord-283202-5fq1wxz8 169 11 diffuse diffuse JJ cord-283202-5fq1wxz8 169 12 interstitial interstitial NN cord-283202-5fq1wxz8 169 13 to to IN cord-283202-5fq1wxz8 169 14 bronchial bronchial JJ cord-283202-5fq1wxz8 169 15 pattern pattern NN cord-283202-5fq1wxz8 169 16 in in IN cord-283202-5fq1wxz8 169 17 which which WDT cord-283202-5fq1wxz8 169 18 infiltrate infiltrate NN cord-283202-5fq1wxz8 169 19 may may MD cord-283202-5fq1wxz8 169 20 coalesce coalesce VB cord-283202-5fq1wxz8 169 21 into into IN cord-283202-5fq1wxz8 169 22 areas area NNS cord-283202-5fq1wxz8 169 23 of of IN cord-283202-5fq1wxz8 169 24 patchy patchy JJ cord-283202-5fq1wxz8 169 25 alveolar alveolar NN cord-283202-5fq1wxz8 169 26 patterns pattern NNS cord-283202-5fq1wxz8 169 27 ( ( -LRB- cord-283202-5fq1wxz8 169 28 Fig Fig NNP cord-283202-5fq1wxz8 169 29 2 2 CD cord-283202-5fq1wxz8 169 30 ) ) -RRB- cord-283202-5fq1wxz8 169 31 . . . cord-283202-5fq1wxz8 170 1 [ [ -LRB- cord-283202-5fq1wxz8 170 2 49 49 CD cord-283202-5fq1wxz8 170 3 ] ] -RRB- cord-283202-5fq1wxz8 170 4 [ [ -LRB- cord-283202-5fq1wxz8 170 5 50 50 CD cord-283202-5fq1wxz8 170 6 ] ] -RRB- cord-283202-5fq1wxz8 171 1 [ [ -LRB- cord-283202-5fq1wxz8 171 2 51 51 CD cord-283202-5fq1wxz8 171 3 ] ] -RRB- cord-283202-5fq1wxz8 171 4 60 60 CD cord-283202-5fq1wxz8 171 5 Neurological neurological JJ cord-283202-5fq1wxz8 171 6 signs sign NNS cord-283202-5fq1wxz8 171 7 ✜ ✜ VBP cord-283202-5fq1wxz8 171 8 Central central JJ cord-283202-5fq1wxz8 171 9 nervous nervous JJ cord-283202-5fq1wxz8 171 10 system system NN cord-283202-5fq1wxz8 171 11 involvement involvement NN cord-283202-5fq1wxz8 171 12 occurs occur VBZ cord-283202-5fq1wxz8 171 13 in in IN cord-283202-5fq1wxz8 171 14 almost almost RB cord-283202-5fq1wxz8 171 15 all all DT cord-283202-5fq1wxz8 171 16 clinically clinically RB cord-283202-5fq1wxz8 171 17 affected affect VBN cord-283202-5fq1wxz8 171 18 cats cat NNS cord-283202-5fq1wxz8 171 19 . . . cord-283202-5fq1wxz8 172 1 50 50 CD cord-283202-5fq1wxz8 172 2 Neurological neurological JJ cord-283202-5fq1wxz8 172 3 signs sign NNS cord-283202-5fq1wxz8 172 4 typically typically RB cord-283202-5fq1wxz8 172 5 reflect reflect VBP cord-283202-5fq1wxz8 172 6 a a DT cord-283202-5fq1wxz8 172 7 multifocal multifocal JJ cord-283202-5fq1wxz8 172 8 distribution distribution NN cord-283202-5fq1wxz8 172 9 and and CC cord-283202-5fq1wxz8 172 10 include include VBP cord-283202-5fq1wxz8 172 11 hypothermia hypothermia NN cord-283202-5fq1wxz8 172 12 , , , cord-283202-5fq1wxz8 172 13 behavioral behavioral JJ cord-283202-5fq1wxz8 172 14 changes change NNS cord-283202-5fq1wxz8 172 15 , , , cord-283202-5fq1wxz8 172 16 seizures seizure NNS cord-283202-5fq1wxz8 172 17 , , , cord-283202-5fq1wxz8 172 18 ataxia ataxia NN cord-283202-5fq1wxz8 172 19 , , , cord-283202-5fq1wxz8 172 20 blindness blindness NN cord-283202-5fq1wxz8 172 21 , , , cord-283202-5fq1wxz8 172 22 anisocoria anisocoria NN cord-283202-5fq1wxz8 172 23 , , , cord-283202-5fq1wxz8 172 24 torticollis torticollis NN cord-283202-5fq1wxz8 172 25 , , , cord-283202-5fq1wxz8 172 26 vestibular vestibular JJ cord-283202-5fq1wxz8 172 27 disease disease NN cord-283202-5fq1wxz8 172 28 , , , cord-283202-5fq1wxz8 172 29 muscle muscle NNP cord-283202-5fq1wxz8 172 30 hyperesthesia hyperesthesia NNP cord-283202-5fq1wxz8 172 31 , , , cord-283202-5fq1wxz8 172 32 and and CC cord-283202-5fq1wxz8 172 33 paresis paresis NN cord-283202-5fq1wxz8 172 34 / / SYM cord-283202-5fq1wxz8 172 35 paralysis paralysis NN cord-283202-5fq1wxz8 172 36 . . . cord-283202-5fq1wxz8 173 1 21 21 CD cord-283202-5fq1wxz8 173 2 _SP cord-283202-5fq1wxz8 174 1 Cerebrospinal cerebrospinal JJ cord-283202-5fq1wxz8 174 2 fluid fluid NN cord-283202-5fq1wxz8 174 3 analysis analysis NN cord-283202-5fq1wxz8 174 4 typically typically RB cord-283202-5fq1wxz8 174 5 reveals reveal VBZ cord-283202-5fq1wxz8 174 6 a a DT cord-283202-5fq1wxz8 174 7 mild mild JJ cord-283202-5fq1wxz8 174 8 lymphocytic lymphocytic JJ cord-283202-5fq1wxz8 174 9 pleocytosis pleocytosis NN cord-283202-5fq1wxz8 174 10 predominantly predominantly RB cord-283202-5fq1wxz8 174 11 , , , cord-283202-5fq1wxz8 174 12 although although IN cord-283202-5fq1wxz8 174 13 other other JJ cord-283202-5fq1wxz8 174 14 cell cell NN cord-283202-5fq1wxz8 174 15 types type NNS cord-283202-5fq1wxz8 174 16 may may MD cord-283202-5fq1wxz8 174 17 be be VB cord-283202-5fq1wxz8 174 18 observed observe VBN cord-283202-5fq1wxz8 174 19 ; ; : cord-283202-5fq1wxz8 174 20 protein protein NN cord-283202-5fq1wxz8 174 21 may may MD cord-283202-5fq1wxz8 174 22 be be VB cord-283202-5fq1wxz8 174 23 elevated elevate VBN cord-283202-5fq1wxz8 174 24 to to IN cord-283202-5fq1wxz8 174 25 up up IN cord-283202-5fq1wxz8 174 26 to to TO cord-283202-5fq1wxz8 174 27 149 149 CD cord-283202-5fq1wxz8 174 28 mg mg NNP cord-283202-5fq1wxz8 174 29 / / SYM cord-283202-5fq1wxz8 174 30 dl dl NN cord-283202-5fq1wxz8 174 31 . . . cord-283202-5fq1wxz8 175 1 39 39 CD cord-283202-5fq1wxz8 175 2 Neutrophilic Neutrophilic NNP cord-283202-5fq1wxz8 175 3 pleocytosis pleocytosis NNP cord-283202-5fq1wxz8 175 4 has have VBZ cord-283202-5fq1wxz8 175 5 also also RB cord-283202-5fq1wxz8 175 6 been be VBN cord-283202-5fq1wxz8 175 7 reported report VBN cord-283202-5fq1wxz8 175 8 . . . cord-283202-5fq1wxz8 176 1 58 58 CD cord-283202-5fq1wxz8 177 1 With with IN cord-283202-5fq1wxz8 177 2 the the DT cord-283202-5fq1wxz8 177 3 exception exception NN cord-283202-5fq1wxz8 177 4 of of IN cord-283202-5fq1wxz8 177 5 identifying identify VBG cord-283202-5fq1wxz8 177 6 T T NNP cord-283202-5fq1wxz8 177 7 gondii gondii NN cord-283202-5fq1wxz8 177 8 in in IN cord-283202-5fq1wxz8 177 9 tissue tissue NN cord-283202-5fq1wxz8 177 10 , , , cord-283202-5fq1wxz8 177 11 no no DT cord-283202-5fq1wxz8 177 12 single single JJ cord-283202-5fq1wxz8 177 13 test test NN cord-283202-5fq1wxz8 177 14 provides provide VBZ cord-283202-5fq1wxz8 177 15 a a DT cord-283202-5fq1wxz8 177 16 definitive definitive JJ cord-283202-5fq1wxz8 177 17 diagnosis diagnosis NN cord-283202-5fq1wxz8 177 18 . . . cord-283202-5fq1wxz8 178 1 A a DT cord-283202-5fq1wxz8 178 2 presumptive presumptive JJ cord-283202-5fq1wxz8 178 3 diagnosis diagnosis NN cord-283202-5fq1wxz8 178 4 is be VBZ cord-283202-5fq1wxz8 178 5 based base VBN cord-283202-5fq1wxz8 178 6 on on IN cord-283202-5fq1wxz8 178 7 a a DT cord-283202-5fq1wxz8 178 8 combination combination NN cord-283202-5fq1wxz8 178 9 of of IN cord-283202-5fq1wxz8 178 10 clinical clinical JJ cord-283202-5fq1wxz8 178 11 signs sign NNS cord-283202-5fq1wxz8 178 12 , , , cord-283202-5fq1wxz8 178 13 evidence evidence NN cord-283202-5fq1wxz8 178 14 of of IN cord-283202-5fq1wxz8 178 15 recent recent JJ cord-283202-5fq1wxz8 178 16 or or CC cord-283202-5fq1wxz8 178 17 active active JJ cord-283202-5fq1wxz8 178 18 infection infection NN cord-283202-5fq1wxz8 178 19 ( ( -LRB- cord-283202-5fq1wxz8 178 20 gained gain VBN cord-283202-5fq1wxz8 178 21 via via IN cord-283202-5fq1wxz8 178 22 serology serology NN cord-283202-5fq1wxz8 178 23 for for IN cord-283202-5fq1wxz8 178 24 immunoglobulins immunoglobulin NNS cord-283202-5fq1wxz8 178 25 or or CC cord-283202-5fq1wxz8 178 26 immune immune JJ cord-283202-5fq1wxz8 178 27 complexes complex NNS cord-283202-5fq1wxz8 178 28 , , , cord-283202-5fq1wxz8 178 29 or or CC cord-283202-5fq1wxz8 178 30 PCR PCR NNP cord-283202-5fq1wxz8 178 31 ) ) -RRB- cord-283202-5fq1wxz8 178 32 , , , cord-283202-5fq1wxz8 178 33 exclusion exclusion NN cord-283202-5fq1wxz8 178 34 of of IN cord-283202-5fq1wxz8 178 35 other other JJ cord-283202-5fq1wxz8 178 36 disease disease NN cord-283202-5fq1wxz8 178 37 processes process NNS cord-283202-5fq1wxz8 178 38 , , , cord-283202-5fq1wxz8 178 39 and and CC cord-283202-5fq1wxz8 178 40 response response NN cord-283202-5fq1wxz8 178 41 to to IN cord-283202-5fq1wxz8 178 42 therapy therapy NN cord-283202-5fq1wxz8 178 43 . . . cord-283202-5fq1wxz8 179 1 39 39 CD cord-283202-5fq1wxz8 179 2 Hypertension hypertension NN cord-283202-5fq1wxz8 179 3 has have VBZ cord-283202-5fq1wxz8 179 4 been be VBN cord-283202-5fq1wxz8 179 5 defined define VBN cord-283202-5fq1wxz8 179 6 as as IN cord-283202-5fq1wxz8 179 7 a a DT cord-283202-5fq1wxz8 179 8 sustained sustained JJ cord-283202-5fq1wxz8 179 9 increase increase NN cord-283202-5fq1wxz8 179 10 in in IN cord-283202-5fq1wxz8 179 11 systolic systolic JJ cord-283202-5fq1wxz8 179 12 blood blood NN cord-283202-5fq1wxz8 179 13 pressure pressure NN cord-283202-5fq1wxz8 179 14 ≥ ≥ CD cord-283202-5fq1wxz8 179 15 160 160 CD cord-283202-5fq1wxz8 179 16 - - SYM cord-283202-5fq1wxz8 179 17 170 170 CD cord-283202-5fq1wxz8 179 18 mmHg mmHg NNS cord-283202-5fq1wxz8 179 19 . . . cord-283202-5fq1wxz8 180 1 75 75 CD cord-283202-5fq1wxz8 180 2 Although although IN cord-283202-5fq1wxz8 180 3 the the DT cord-283202-5fq1wxz8 180 4 prevalence prevalence NN cord-283202-5fq1wxz8 180 5 of of IN cord-283202-5fq1wxz8 180 6 hypertension hypertension NN cord-283202-5fq1wxz8 180 7 in in IN cord-283202-5fq1wxz8 180 8 cats cat NNS cord-283202-5fq1wxz8 180 9 has have VBZ cord-283202-5fq1wxz8 180 10 not not RB cord-283202-5fq1wxz8 180 11 been be VBN cord-283202-5fq1wxz8 180 12 accurately accurately RB cord-283202-5fq1wxz8 180 13 established establish VBN cord-283202-5fq1wxz8 180 14 , , , cord-283202-5fq1wxz8 180 15 one one CD cord-283202-5fq1wxz8 180 16 study study NN cord-283202-5fq1wxz8 180 17 documented document VBD cord-283202-5fq1wxz8 180 18 hypertension hypertension NN cord-283202-5fq1wxz8 180 19 in in IN cord-283202-5fq1wxz8 180 20 2 2 CD cord-283202-5fq1wxz8 180 21 % % NN cord-283202-5fq1wxz8 180 22 of of IN cord-283202-5fq1wxz8 180 23 healthy healthy JJ cord-283202-5fq1wxz8 180 24 cats cat NNS cord-283202-5fq1wxz8 180 25 . . . cord-283202-5fq1wxz8 181 1 80 80 CD cord-283202-5fq1wxz8 182 1 In in IN cord-283202-5fq1wxz8 182 2 cats cat NNS cord-283202-5fq1wxz8 182 3 referred refer VBD cord-283202-5fq1wxz8 182 4 for for IN cord-283202-5fq1wxz8 182 5 evaluation evaluation NN cord-283202-5fq1wxz8 182 6 of of IN cord-283202-5fq1wxz8 182 7 disease disease NN cord-283202-5fq1wxz8 182 8 associated associate VBN cord-283202-5fq1wxz8 182 9 with with IN cord-283202-5fq1wxz8 182 10 hypertension hypertension NN cord-283202-5fq1wxz8 182 11 , , , cord-283202-5fq1wxz8 182 12 or or CC cord-283202-5fq1wxz8 182 13 animals animal NNS cord-283202-5fq1wxz8 182 14 with with IN cord-283202-5fq1wxz8 182 15 clinical clinical JJ cord-283202-5fq1wxz8 182 16 signs sign NNS cord-283202-5fq1wxz8 182 17 compatible compatible JJ cord-283202-5fq1wxz8 182 18 with with IN cord-283202-5fq1wxz8 182 19 hypertension hypertension NN cord-283202-5fq1wxz8 182 20 , , , cord-283202-5fq1wxz8 182 21 a a DT cord-283202-5fq1wxz8 182 22 30 30 CD cord-283202-5fq1wxz8 182 23 % % NN cord-283202-5fq1wxz8 182 24 prevalence prevalence NN cord-283202-5fq1wxz8 182 25 was be VBD cord-283202-5fq1wxz8 182 26 found find VBN cord-283202-5fq1wxz8 182 27 . . . cord-283202-5fq1wxz8 183 1 79 79 CD cord-283202-5fq1wxz8 183 2 Hypertension hypertension NN cord-283202-5fq1wxz8 183 3 can can MD cord-283202-5fq1wxz8 183 4 be be VB cord-283202-5fq1wxz8 183 5 divided divide VBN cord-283202-5fq1wxz8 183 6 into into IN cord-283202-5fq1wxz8 183 7 three three CD cord-283202-5fq1wxz8 183 8 categories category NNS cord-283202-5fq1wxz8 183 9 : : : cord-283202-5fq1wxz8 183 10 white white JJ cord-283202-5fq1wxz8 183 11 coat coat NN cord-283202-5fq1wxz8 183 12 , , , cord-283202-5fq1wxz8 183 13 secondary secondary JJ cord-283202-5fq1wxz8 183 14 and and CC cord-283202-5fq1wxz8 183 15 idiopathic idiopathic JJ cord-283202-5fq1wxz8 183 16 . . . cord-283202-5fq1wxz8 184 1 ✜ ✜ NNP cord-283202-5fq1wxz8 184 2 White White NNP cord-283202-5fq1wxz8 184 3 coat coat NN cord-283202-5fq1wxz8 184 4 hypertension hypertension NN cord-283202-5fq1wxz8 184 5 is be VBZ cord-283202-5fq1wxz8 184 6 an an DT cord-283202-5fq1wxz8 184 7 artefactual artefactual JJ cord-283202-5fq1wxz8 184 8 increase increase NN cord-283202-5fq1wxz8 184 9 in in IN cord-283202-5fq1wxz8 184 10 blood blood NN cord-283202-5fq1wxz8 184 11 pressure pressure NN cord-283202-5fq1wxz8 184 12 that that WDT cord-283202-5fq1wxz8 184 13 develops develop VBZ cord-283202-5fq1wxz8 184 14 secondarily secondarily RB cord-283202-5fq1wxz8 184 15 to to IN cord-283202-5fq1wxz8 184 16 excitement excitement NN cord-283202-5fq1wxz8 184 17 or or CC cord-283202-5fq1wxz8 184 18 anxiety anxiety NN cord-283202-5fq1wxz8 184 19 , , , cord-283202-5fq1wxz8 184 20 and and CC cord-283202-5fq1wxz8 184 21 is be VBZ cord-283202-5fq1wxz8 184 22 likely likely JJ cord-283202-5fq1wxz8 184 23 to to TO cord-283202-5fq1wxz8 184 24 be be VB cord-283202-5fq1wxz8 184 25 the the DT cord-283202-5fq1wxz8 184 26 result result NN cord-283202-5fq1wxz8 184 27 of of IN cord-283202-5fq1wxz8 184 28 activation activation NN cord-283202-5fq1wxz8 184 29 of of IN cord-283202-5fq1wxz8 184 30 the the DT cord-283202-5fq1wxz8 184 31 sympathetic sympathetic JJ cord-283202-5fq1wxz8 184 32 nervous nervous JJ cord-283202-5fq1wxz8 184 33 system system NN cord-283202-5fq1wxz8 184 34 . . . cord-283202-5fq1wxz8 185 1 81 81 CD cord-283202-5fq1wxz8 186 1 It -PRON- PRP cord-283202-5fq1wxz8 186 2 is be VBZ cord-283202-5fq1wxz8 186 3 observed observe VBN cord-283202-5fq1wxz8 186 4 in in IN cord-283202-5fq1wxz8 186 5 cats cat NNS cord-283202-5fq1wxz8 186 6 , , , cord-283202-5fq1wxz8 186 7 and and CC cord-283202-5fq1wxz8 186 8 results result VBZ cord-283202-5fq1wxz8 186 9 in in IN cord-283202-5fq1wxz8 186 10 a a DT cord-283202-5fq1wxz8 186 11 median median JJ cord-283202-5fq1wxz8 186 12 increase increase NN cord-283202-5fq1wxz8 186 13 in in IN cord-283202-5fq1wxz8 186 14 systolic systolic JJ cord-283202-5fq1wxz8 186 15 blood blood NN cord-283202-5fq1wxz8 186 16 pressure pressure NN cord-283202-5fq1wxz8 186 17 of of IN cord-283202-5fq1wxz8 186 18 17.6 17.6 CD cord-283202-5fq1wxz8 186 19 mmHg mmHg NNP cord-283202-5fq1wxz8 186 20 ± ± NNP cord-283202-5fq1wxz8 186 21 1.5 1.5 CD cord-283202-5fq1wxz8 186 22 mmHg mmHg NNS cord-283202-5fq1wxz8 186 23 . . . cord-283202-5fq1wxz8 186 24 81 81 CD cord-283202-5fq1wxz8 187 1 Although although IN cord-283202-5fq1wxz8 187 2 PCR PCR NNP cord-283202-5fq1wxz8 187 3 assays assay NNS cord-283202-5fq1wxz8 187 4 have have VBP cord-283202-5fq1wxz8 187 5 not not RB cord-283202-5fq1wxz8 187 6 been be VBN cord-283202-5fq1wxz8 187 7 performed perform VBN cord-283202-5fq1wxz8 187 8 on on IN cord-283202-5fq1wxz8 187 9 CSF CSF NNP cord-283202-5fq1wxz8 187 10 for for IN cord-283202-5fq1wxz8 187 11 the the DT cord-283202-5fq1wxz8 187 12 detection detection NN cord-283202-5fq1wxz8 187 13 of of IN cord-283202-5fq1wxz8 187 14 T T NNP cord-283202-5fq1wxz8 187 15 gondii gondii NN cord-283202-5fq1wxz8 187 16 , , , cord-283202-5fq1wxz8 187 17 PCR PCR NNP cord-283202-5fq1wxz8 187 18 assays assay NNS cord-283202-5fq1wxz8 187 19 have have VBP cord-283202-5fq1wxz8 187 20 been be VBN cord-283202-5fq1wxz8 187 21 utilized utilize VBN cord-283202-5fq1wxz8 187 22 in in IN cord-283202-5fq1wxz8 187 23 the the DT cord-283202-5fq1wxz8 187 24 aqueous aqueous JJ cord-283202-5fq1wxz8 187 25 humor humor NN cord-283202-5fq1wxz8 187 26 , , , cord-283202-5fq1wxz8 187 27 another another DT cord-283202-5fq1wxz8 187 28 immunoprivileged immunoprivilege VBN cord-283202-5fq1wxz8 187 29 site site NN cord-283202-5fq1wxz8 187 30 . . . cord-283202-5fq1wxz8 188 1 66 66 CD cord-283202-5fq1wxz8 188 2 , , , cord-283202-5fq1wxz8 188 3 67 67 CD cord-283202-5fq1wxz8 188 4 Toxoplasma toxoplasma NN cord-283202-5fq1wxz8 188 5 gondii gondii NN cord-283202-5fq1wxz8 188 6 can can MD cord-283202-5fq1wxz8 188 7 be be VB cord-283202-5fq1wxz8 188 8 identified identify VBN cord-283202-5fq1wxz8 188 9 in in IN cord-283202-5fq1wxz8 188 10 the the DT cord-283202-5fq1wxz8 188 11 aqueous aqueous JJ cord-283202-5fq1wxz8 188 12 humor humor NN cord-283202-5fq1wxz8 188 13 of of IN cord-283202-5fq1wxz8 188 14 cats cat NNS cord-283202-5fq1wxz8 188 15 with with IN cord-283202-5fq1wxz8 188 16 uveitis uveitis NN cord-283202-5fq1wxz8 188 17 using use VBG cord-283202-5fq1wxz8 188 18 PCR PCR NNP cord-283202-5fq1wxz8 188 19 ; ; : cord-283202-5fq1wxz8 188 20 however however RB cord-283202-5fq1wxz8 188 21 , , , cord-283202-5fq1wxz8 188 22 the the DT cord-283202-5fq1wxz8 188 23 organism organism NN cord-283202-5fq1wxz8 188 24 can can MD cord-283202-5fq1wxz8 188 25 also also RB cord-283202-5fq1wxz8 188 26 be be VB cord-283202-5fq1wxz8 188 27 detected detect VBN cord-283202-5fq1wxz8 188 28 in in IN cord-283202-5fq1wxz8 188 29 the the DT cord-283202-5fq1wxz8 188 30 aqueous aqueous JJ cord-283202-5fq1wxz8 188 31 humor humor NN cord-283202-5fq1wxz8 188 32 of of IN cord-283202-5fq1wxz8 188 33 clinically clinically RB cord-283202-5fq1wxz8 188 34 normal normal JJ cord-283202-5fq1wxz8 188 35 cats cat NNS cord-283202-5fq1wxz8 188 36 that that WDT cord-283202-5fq1wxz8 188 37 have have VBP cord-283202-5fq1wxz8 188 38 naturally naturally RB cord-283202-5fq1wxz8 188 39 been be VBN cord-283202-5fq1wxz8 188 40 exposed expose VBN cord-283202-5fq1wxz8 188 41 to to IN cord-283202-5fq1wxz8 188 42 T T NNP cord-283202-5fq1wxz8 188 43 gondii gondii NNP cord-283202-5fq1wxz8 188 44 . . . cord-283202-5fq1wxz8 189 1 66 66 CD cord-283202-5fq1wxz8 190 1 Consequently consequently RB cord-283202-5fq1wxz8 190 2 , , , cord-283202-5fq1wxz8 190 3 PCR PCR NNP cord-283202-5fq1wxz8 190 4 detection detection NN cord-283202-5fq1wxz8 190 5 of of IN cord-283202-5fq1wxz8 190 6 T T NNP cord-283202-5fq1wxz8 190 7 gondii gondii NN cord-283202-5fq1wxz8 190 8 in in IN cord-283202-5fq1wxz8 190 9 aqueous aqueous JJ cord-283202-5fq1wxz8 190 10 humor humor NN cord-283202-5fq1wxz8 190 11 does do VBZ cord-283202-5fq1wxz8 190 12 not not RB cord-283202-5fq1wxz8 190 13 provide provide VB cord-283202-5fq1wxz8 190 14 definitive definitive JJ cord-283202-5fq1wxz8 190 15 proof proof NN cord-283202-5fq1wxz8 190 16 of of IN cord-283202-5fq1wxz8 190 17 active active JJ cord-283202-5fq1wxz8 190 18 disease disease NN cord-283202-5fq1wxz8 190 19 . . . cord-283202-5fq1wxz8 191 1 A a DT cord-283202-5fq1wxz8 191 2 similar similar JJ cord-283202-5fq1wxz8 191 3 interpretation interpretation NN cord-283202-5fq1wxz8 191 4 of of IN cord-283202-5fq1wxz8 191 5 PCR PCR NNP cord-283202-5fq1wxz8 191 6 analysis analysis NN cord-283202-5fq1wxz8 191 7 of of IN cord-283202-5fq1wxz8 191 8 CSF CSF NNP cord-283202-5fq1wxz8 191 9 is be VBZ cord-283202-5fq1wxz8 191 10 likely likely JJ cord-283202-5fq1wxz8 191 11 . . . cord-283202-5fq1wxz8 192 1 Unfortunately unfortunately RB cord-283202-5fq1wxz8 192 2 , , , cord-283202-5fq1wxz8 192 3 the the DT cord-283202-5fq1wxz8 192 4 prognosis prognosis NN cord-283202-5fq1wxz8 192 5 is be VBZ cord-283202-5fq1wxz8 192 6 poor poor JJ cord-283202-5fq1wxz8 192 7 for for IN cord-283202-5fq1wxz8 192 8 cats cat NNS cord-283202-5fq1wxz8 192 9 displaying display VBG cord-283202-5fq1wxz8 192 10 neurological neurological JJ cord-283202-5fq1wxz8 192 11 signs sign NNS cord-283202-5fq1wxz8 192 12 or or CC cord-283202-5fq1wxz8 192 13 severe severe JJ cord-283202-5fq1wxz8 192 14 respiratory respiratory JJ cord-283202-5fq1wxz8 192 15 disease disease NN cord-283202-5fq1wxz8 192 16 as as IN cord-283202-5fq1wxz8 192 17 most most JJS cord-283202-5fq1wxz8 192 18 will will MD cord-283202-5fq1wxz8 192 19 succumb succumb VB cord-283202-5fq1wxz8 192 20 to to IN cord-283202-5fq1wxz8 192 21 the the DT cord-283202-5fq1wxz8 192 22 disease disease NN cord-283202-5fq1wxz8 192 23 . . . cord-283202-5fq1wxz8 193 1 21 21 CD cord-283202-5fq1wxz8 193 2 , , , cord-283202-5fq1wxz8 193 3 [ [ -LRB- cord-283202-5fq1wxz8 193 4 56 56 CD cord-283202-5fq1wxz8 193 5 ] ] -RRB- cord-283202-5fq1wxz8 193 6 [ [ -LRB- cord-283202-5fq1wxz8 193 7 57 57 CD cord-283202-5fq1wxz8 193 8 ] ] -RRB- cord-283202-5fq1wxz8 193 9 [ [ -LRB- cord-283202-5fq1wxz8 193 10 58 58 CD cord-283202-5fq1wxz8 193 11 ] ] -RRB- cord-283202-5fq1wxz8 193 12 60 60 CD cord-283202-5fq1wxz8 193 13 , , , cord-283202-5fq1wxz8 193 14 73 73 CD cord-283202-5fq1wxz8 194 1 Despite despite IN cord-283202-5fq1wxz8 194 2 this this DT cord-283202-5fq1wxz8 194 3 , , , cord-283202-5fq1wxz8 194 4 cats cat NNS cord-283202-5fq1wxz8 194 5 with with IN cord-283202-5fq1wxz8 194 6 focal focal JJ cord-283202-5fq1wxz8 194 7 CNS cns JJ cord-283202-5fq1wxz8 194 8 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 194 9 may may MD cord-283202-5fq1wxz8 194 10 achieve achieve VB cord-283202-5fq1wxz8 194 11 long long JJ cord-283202-5fq1wxz8 194 12 term term NN cord-283202-5fq1wxz8 194 13 remission remission NN cord-283202-5fq1wxz8 194 14 . . . cord-283202-5fq1wxz8 195 1 59 59 CD cord-283202-5fq1wxz8 196 1 Since since IN cord-283202-5fq1wxz8 196 2 the the DT cord-283202-5fq1wxz8 196 3 initial initial JJ cord-283202-5fq1wxz8 196 4 description description NN cord-283202-5fq1wxz8 196 5 of of IN cord-283202-5fq1wxz8 196 6 systemic systemic JJ cord-283202-5fq1wxz8 196 7 hypertension hypertension NN cord-283202-5fq1wxz8 196 8 in in IN cord-283202-5fq1wxz8 196 9 cats cat NNS cord-283202-5fq1wxz8 196 10 , , , cord-283202-5fq1wxz8 196 11 74 74 CD cord-283202-5fq1wxz8 196 12 the the DT cord-283202-5fq1wxz8 196 13 impact impact NN cord-283202-5fq1wxz8 196 14 of of IN cord-283202-5fq1wxz8 196 15 hypertension hypertension NN cord-283202-5fq1wxz8 196 16 systemically systemically RB cord-283202-5fq1wxz8 196 17 and and CC cord-283202-5fq1wxz8 196 18 on on IN cord-283202-5fq1wxz8 196 19 the the DT cord-283202-5fq1wxz8 196 20 nervous nervous JJ cord-283202-5fq1wxz8 196 21 system system NN cord-283202-5fq1wxz8 196 22 has have VBZ cord-283202-5fq1wxz8 196 23 become become VBN cord-283202-5fq1wxz8 196 24 increasingly increasingly RB cord-283202-5fq1wxz8 196 25 recognized recognize VBN cord-283202-5fq1wxz8 196 26 . . . cord-283202-5fq1wxz8 197 1 A a DT cord-283202-5fq1wxz8 197 2 testament testament NN cord-283202-5fq1wxz8 197 3 to to IN cord-283202-5fq1wxz8 197 4 this this DT cord-283202-5fq1wxz8 197 5 is be VBZ cord-283202-5fq1wxz8 197 6 a a DT cord-283202-5fq1wxz8 197 7 recent recent JJ cord-283202-5fq1wxz8 197 8 consensus consensus NN cord-283202-5fq1wxz8 197 9 statement statement NN cord-283202-5fq1wxz8 197 10 from from IN cord-283202-5fq1wxz8 197 11 the the DT cord-283202-5fq1wxz8 197 12 American American NNP cord-283202-5fq1wxz8 197 13 College College NNP cord-283202-5fq1wxz8 197 14 of of IN cord-283202-5fq1wxz8 197 15 Veterinary Veterinary NNP cord-283202-5fq1wxz8 197 16 Internal Internal NNP cord-283202-5fq1wxz8 197 17 Medicine Medicine NNP cord-283202-5fq1wxz8 197 18 that that WDT cord-283202-5fq1wxz8 197 19 has have VBZ cord-283202-5fq1wxz8 197 20 established establish VBN cord-283202-5fq1wxz8 197 21 guidelines guideline NNS cord-283202-5fq1wxz8 197 22 for for IN cord-283202-5fq1wxz8 197 23 identification identification NN cord-283202-5fq1wxz8 197 24 , , , cord-283202-5fq1wxz8 197 25 evaluation evaluation NN cord-283202-5fq1wxz8 197 26 and and CC cord-283202-5fq1wxz8 197 27 management management NN cord-283202-5fq1wxz8 197 28 of of IN cord-283202-5fq1wxz8 197 29 hypertension hypertension NN cord-283202-5fq1wxz8 197 30 in in IN cord-283202-5fq1wxz8 197 31 dogs dog NNS cord-283202-5fq1wxz8 197 32 and and CC cord-283202-5fq1wxz8 197 33 cats cat NNS cord-283202-5fq1wxz8 197 34 . . . cord-283202-5fq1wxz8 198 1 75 75 CD cord-283202-5fq1wxz8 199 1 In in IN cord-283202-5fq1wxz8 199 2 healthy healthy JJ cord-283202-5fq1wxz8 199 3 cats cat NNS cord-283202-5fq1wxz8 199 4 , , , cord-283202-5fq1wxz8 199 5 normal normal JJ cord-283202-5fq1wxz8 199 6 systemic systemic JJ cord-283202-5fq1wxz8 199 7 blood blood NN cord-283202-5fq1wxz8 199 8 pressure pressure NN cord-283202-5fq1wxz8 199 9 , , , cord-283202-5fq1wxz8 199 10 which which WDT cord-283202-5fq1wxz8 199 11 is be VBZ cord-283202-5fq1wxz8 199 12 often often RB cord-283202-5fq1wxz8 199 13 reported report VBN cord-283202-5fq1wxz8 199 14 as as IN cord-283202-5fq1wxz8 199 15 a a DT cord-283202-5fq1wxz8 199 16 systolic systolic JJ cord-283202-5fq1wxz8 199 17 measurement measurement NN cord-283202-5fq1wxz8 199 18 , , , cord-283202-5fq1wxz8 199 19 is be VBZ cord-283202-5fq1wxz8 199 20 118 118 CD cord-283202-5fq1wxz8 199 21 - - SYM cord-283202-5fq1wxz8 199 22 162 162 CD cord-283202-5fq1wxz8 199 23 mmHg mmHg NNS cord-283202-5fq1wxz8 199 24 . . . cord-283202-5fq1wxz8 200 1 [ [ -LRB- cord-283202-5fq1wxz8 200 2 75 75 CD cord-283202-5fq1wxz8 200 3 ] ] -RRB- cord-283202-5fq1wxz8 200 4 [ [ -LRB- cord-283202-5fq1wxz8 200 5 76 76 CD cord-283202-5fq1wxz8 200 6 ] ] -RRB- cord-283202-5fq1wxz8 200 7 [ [ -LRB- cord-283202-5fq1wxz8 200 8 77 77 CD cord-283202-5fq1wxz8 200 9 ] ] -RRB- cord-283202-5fq1wxz8 201 1 The the DT cord-283202-5fq1wxz8 201 2 wide wide JJ cord-283202-5fq1wxz8 201 3 range range NN cord-283202-5fq1wxz8 201 4 in in IN cord-283202-5fq1wxz8 201 5 the the DT cord-283202-5fq1wxz8 201 6 reported reported JJ cord-283202-5fq1wxz8 201 7 normal normal JJ cord-283202-5fq1wxz8 201 8 values value NNS cord-283202-5fq1wxz8 201 9 is be VBZ cord-283202-5fq1wxz8 201 10 likely likely JJ cord-283202-5fq1wxz8 201 11 to to TO cord-283202-5fq1wxz8 201 12 reflect reflect VB cord-283202-5fq1wxz8 201 13 a a DT cord-283202-5fq1wxz8 201 14 lack lack NN cord-283202-5fq1wxz8 201 15 of of IN cord-283202-5fq1wxz8 201 16 standardization standardization NN cord-283202-5fq1wxz8 201 17 in in IN cord-283202-5fq1wxz8 201 18 technique technique NN cord-283202-5fq1wxz8 201 19 and and CC cord-283202-5fq1wxz8 201 20 equipment equipment NN cord-283202-5fq1wxz8 201 21 used use VBN cord-283202-5fq1wxz8 201 22 to to TO cord-283202-5fq1wxz8 201 23 measure measure VB cord-283202-5fq1wxz8 201 24 blood blood NN cord-283202-5fq1wxz8 201 25 pressure pressure NN cord-283202-5fq1wxz8 201 26 . . . cord-283202-5fq1wxz8 202 1 75 75 CD cord-283202-5fq1wxz8 203 1 Many many JJ cord-283202-5fq1wxz8 203 2 factors factor NNS cord-283202-5fq1wxz8 203 3 affect affect VBP cord-283202-5fq1wxz8 203 4 blood blood NN cord-283202-5fq1wxz8 203 5 pressure pressure NN cord-283202-5fq1wxz8 203 6 measurement measurement NN cord-283202-5fq1wxz8 203 7 including include VBG cord-283202-5fq1wxz8 203 8 recording record VBG cord-283202-5fq1wxz8 203 9 device device NN cord-283202-5fq1wxz8 203 10 , , , cord-283202-5fq1wxz8 203 11 cuff cuff NN cord-283202-5fq1wxz8 203 12 size size NN cord-283202-5fq1wxz8 203 13 and and CC cord-283202-5fq1wxz8 203 14 operator operator NN cord-283202-5fq1wxz8 203 15 skill skill NN cord-283202-5fq1wxz8 203 16 , , , cord-283202-5fq1wxz8 203 17 as as RB cord-283202-5fq1wxz8 203 18 well well RB cord-283202-5fq1wxz8 203 19 as as IN cord-283202-5fq1wxz8 203 20 patient patient JJ cord-283202-5fq1wxz8 203 21 factors factor NNS cord-283202-5fq1wxz8 203 22 such such JJ cord-283202-5fq1wxz8 203 23 as as IN cord-283202-5fq1wxz8 203 24 size size NN cord-283202-5fq1wxz8 203 25 and and CC cord-283202-5fq1wxz8 203 26 demeanor demeanor NN cord-283202-5fq1wxz8 203 27 of of IN cord-283202-5fq1wxz8 203 28 the the DT cord-283202-5fq1wxz8 203 29 cat cat NN cord-283202-5fq1wxz8 203 30 . . . cord-283202-5fq1wxz8 204 1 Although although IN cord-283202-5fq1wxz8 204 2 increasing increase VBG cord-283202-5fq1wxz8 204 3 age age NN cord-283202-5fq1wxz8 204 4 was be VBD cord-283202-5fq1wxz8 204 5 found find VBN cord-283202-5fq1wxz8 204 6 to to TO cord-283202-5fq1wxz8 204 7 be be VB cord-283202-5fq1wxz8 204 8 associated associate VBN cord-283202-5fq1wxz8 204 9 with with IN cord-283202-5fq1wxz8 204 10 increased increase VBN cord-283202-5fq1wxz8 204 11 blood blood NN cord-283202-5fq1wxz8 204 12 pressure pressure NN cord-283202-5fq1wxz8 204 13 in in IN cord-283202-5fq1wxz8 204 14 one one CD cord-283202-5fq1wxz8 204 15 study study NN cord-283202-5fq1wxz8 204 16 , , , cord-283202-5fq1wxz8 204 17 other other JJ cord-283202-5fq1wxz8 204 18 reports report NNS cord-283202-5fq1wxz8 204 19 have have VBP cord-283202-5fq1wxz8 204 20 found find VBN cord-283202-5fq1wxz8 204 21 no no DT cord-283202-5fq1wxz8 204 22 effect effect NN cord-283202-5fq1wxz8 204 23 of of IN cord-283202-5fq1wxz8 204 24 age age NN cord-283202-5fq1wxz8 204 25 on on IN cord-283202-5fq1wxz8 204 26 blood blood NN cord-283202-5fq1wxz8 204 27 pressure pressure NN cord-283202-5fq1wxz8 204 28 . . . cord-283202-5fq1wxz8 205 1 [ [ -LRB- cord-283202-5fq1wxz8 205 2 77 77 CD cord-283202-5fq1wxz8 205 3 ] ] -RRB- cord-283202-5fq1wxz8 205 4 [ [ -LRB- cord-283202-5fq1wxz8 205 5 78 78 CD cord-283202-5fq1wxz8 205 6 ] ] -RRB- cord-283202-5fq1wxz8 206 1 [ [ -LRB- cord-283202-5fq1wxz8 206 2 79 79 CD cord-283202-5fq1wxz8 206 3 ] ] -RRB- cord-283202-5fq1wxz8 206 4 _SP cord-283202-5fq1wxz8 207 1 The the DT cord-283202-5fq1wxz8 207 2 treatment treatment NN cord-283202-5fq1wxz8 207 3 of of IN cord-283202-5fq1wxz8 207 4 choice choice NN cord-283202-5fq1wxz8 207 5 for for IN cord-283202-5fq1wxz8 207 6 cats cat NNS cord-283202-5fq1wxz8 207 7 with with IN cord-283202-5fq1wxz8 207 8 clinical clinical JJ cord-283202-5fq1wxz8 207 9 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 207 10 is be VBZ cord-283202-5fq1wxz8 207 11 clindamycin clindamycin NN cord-283202-5fq1wxz8 207 12 hydrochloride hydrochloride NN cord-283202-5fq1wxz8 207 13 at at IN cord-283202-5fq1wxz8 208 1 12 12 CD cord-283202-5fq1wxz8 208 2 - - SYM cord-283202-5fq1wxz8 208 3 25 25 CD cord-283202-5fq1wxz8 208 4 mg mg NNP cord-283202-5fq1wxz8 208 5 / / SYM cord-283202-5fq1wxz8 208 6 kg kg NNS cord-283202-5fq1wxz8 208 7 divided divide VBN cord-283202-5fq1wxz8 208 8 per per IN cord-283202-5fq1wxz8 208 9 day day NN cord-283202-5fq1wxz8 208 10 . . . cord-283202-5fq1wxz8 209 1 39 39 CD cord-283202-5fq1wxz8 209 2 , , , cord-283202-5fq1wxz8 209 3 42 42 CD cord-283202-5fq1wxz8 209 4 Clindamycin clindamycin NN cord-283202-5fq1wxz8 209 5 is be VBZ cord-283202-5fq1wxz8 209 6 almost almost RB cord-283202-5fq1wxz8 209 7 completely completely RB cord-283202-5fq1wxz8 209 8 absorbed absorb VBN cord-283202-5fq1wxz8 209 9 after after IN cord-283202-5fq1wxz8 209 10 oral oral JJ cord-283202-5fq1wxz8 209 11 administration administration NN cord-283202-5fq1wxz8 209 12 and and CC cord-283202-5fq1wxz8 209 13 achieves achieve VBZ cord-283202-5fq1wxz8 209 14 high high JJ cord-283202-5fq1wxz8 209 15 concentrations concentration NNS cord-283202-5fq1wxz8 209 16 in in IN cord-283202-5fq1wxz8 209 17 most most JJS cord-283202-5fq1wxz8 209 18 tissues tissue NNS cord-283202-5fq1wxz8 209 19 , , , cord-283202-5fq1wxz8 209 20 including include VBG cord-283202-5fq1wxz8 209 21 the the DT cord-283202-5fq1wxz8 209 22 lung lung NN cord-283202-5fq1wxz8 209 23 . . . cord-283202-5fq1wxz8 210 1 68 68 CD cord-283202-5fq1wxz8 210 2 Concentrations concentration NNS cord-283202-5fq1wxz8 210 3 in in IN cord-283202-5fq1wxz8 210 4 CSF CSF NNP cord-283202-5fq1wxz8 210 5 are be VBP cord-283202-5fq1wxz8 210 6 low low JJ cord-283202-5fq1wxz8 210 7 ; ; : cord-283202-5fq1wxz8 210 8 69,70 69,70 CD cord-283202-5fq1wxz8 210 9 however however RB cord-283202-5fq1wxz8 210 10 , , , cord-283202-5fq1wxz8 210 11 the the DT cord-283202-5fq1wxz8 210 12 concentration concentration NN cord-283202-5fq1wxz8 210 13 in in IN cord-283202-5fq1wxz8 210 14 the the DT cord-283202-5fq1wxz8 210 15 brain brain NN cord-283202-5fq1wxz8 210 16 may may MD cord-283202-5fq1wxz8 210 17 be be VB cord-283202-5fq1wxz8 210 18 higher high JJR cord-283202-5fq1wxz8 210 19 given give VBN cord-283202-5fq1wxz8 210 20 the the DT cord-283202-5fq1wxz8 210 21 lipophilic lipophilic JJ cord-283202-5fq1wxz8 210 22 nature nature NN cord-283202-5fq1wxz8 210 23 of of IN cord-283202-5fq1wxz8 210 24 the the DT cord-283202-5fq1wxz8 210 25 drug drug NN cord-283202-5fq1wxz8 210 26 . . . cord-283202-5fq1wxz8 211 1 71 71 CD cord-283202-5fq1wxz8 211 2 Clindamycin clindamycin NN cord-283202-5fq1wxz8 211 3 is be VBZ cord-283202-5fq1wxz8 211 4 well well RB cord-283202-5fq1wxz8 211 5 tolerated tolerate VBN cord-283202-5fq1wxz8 211 6 , , , cord-283202-5fq1wxz8 211 7 with with IN cord-283202-5fq1wxz8 211 8 only only JJ cord-283202-5fq1wxz8 211 9 minimal minimal JJ cord-283202-5fq1wxz8 211 10 side side NN cord-283202-5fq1wxz8 211 11 effects effect NNS cord-283202-5fq1wxz8 211 12 ( ( -LRB- cord-283202-5fq1wxz8 211 13 eg eg IN cord-283202-5fq1wxz8 211 14 , , , cord-283202-5fq1wxz8 211 15 vomiting vomiting NN cord-283202-5fq1wxz8 211 16 and and CC cord-283202-5fq1wxz8 211 17 diarrhea diarrhea NN cord-283202-5fq1wxz8 211 18 ) ) -RRB- cord-283202-5fq1wxz8 211 19 reported report VBD cord-283202-5fq1wxz8 211 20 at at IN cord-283202-5fq1wxz8 211 21 dosages dosage NNS cord-283202-5fq1wxz8 211 22 two two CD cord-283202-5fq1wxz8 211 23 and and CC cord-283202-5fq1wxz8 211 24 a a DT cord-283202-5fq1wxz8 211 25 half half NN cord-283202-5fq1wxz8 211 26 to to IN cord-283202-5fq1wxz8 211 27 four four CD cord-283202-5fq1wxz8 211 28 times time NNS cord-283202-5fq1wxz8 211 29 the the DT cord-283202-5fq1wxz8 211 30 recommended recommend VBN cord-283202-5fq1wxz8 211 31 dosage dosage NN cord-283202-5fq1wxz8 211 32 . . . cord-283202-5fq1wxz8 212 1 72 72 CD cord-283202-5fq1wxz8 212 2 Parenteral Parenteral NNP cord-283202-5fq1wxz8 212 3 formulations formulation NNS cord-283202-5fq1wxz8 212 4 can can MD cord-283202-5fq1wxz8 212 5 be be VB cord-283202-5fq1wxz8 212 6 used use VBN cord-283202-5fq1wxz8 212 7 in in IN cord-283202-5fq1wxz8 212 8 animals animal NNS cord-283202-5fq1wxz8 212 9 unable unable JJ cord-283202-5fq1wxz8 212 10 to to TO cord-283202-5fq1wxz8 212 11 receive receive VB cord-283202-5fq1wxz8 212 12 oral oral JJ cord-283202-5fq1wxz8 212 13 medication medication NN cord-283202-5fq1wxz8 212 14 or or CC cord-283202-5fq1wxz8 212 15 those those DT cord-283202-5fq1wxz8 212 16 experiencing experience VBG cord-283202-5fq1wxz8 212 17 gastrointestinal gastrointestinal JJ cord-283202-5fq1wxz8 212 18 toxicity toxicity NN cord-283202-5fq1wxz8 212 19 . . . cord-283202-5fq1wxz8 213 1 Reports report NNS cord-283202-5fq1wxz8 213 2 of of IN cord-283202-5fq1wxz8 213 3 successful successful JJ cord-283202-5fq1wxz8 213 4 treatment treatment NN cord-283202-5fq1wxz8 213 5 are be VBP cord-283202-5fq1wxz8 213 6 rare rare JJ cord-283202-5fq1wxz8 213 7 , , , cord-283202-5fq1wxz8 213 8 which which WDT cord-283202-5fq1wxz8 213 9 may may MD cord-283202-5fq1wxz8 213 10 reflect reflect VB cord-283202-5fq1wxz8 213 11 the the DT cord-283202-5fq1wxz8 213 12 difficulty difficulty NN cord-283202-5fq1wxz8 213 13 of of IN cord-283202-5fq1wxz8 213 14 establishing establish VBG cord-283202-5fq1wxz8 213 15 a a DT cord-283202-5fq1wxz8 213 16 definitive definitive JJ cord-283202-5fq1wxz8 213 17 diagnosis diagnosis NN cord-283202-5fq1wxz8 213 18 . . . cord-283202-5fq1wxz8 214 1 Systemic systemic JJ cord-283202-5fq1wxz8 214 2 clinical clinical JJ cord-283202-5fq1wxz8 214 3 signs sign NNS cord-283202-5fq1wxz8 214 4 typically typically RB cord-283202-5fq1wxz8 214 5 show show VBP cord-283202-5fq1wxz8 214 6 improvement improvement NN cord-283202-5fq1wxz8 214 7 within within IN cord-283202-5fq1wxz8 214 8 24 24 CD cord-283202-5fq1wxz8 214 9 - - SYM cord-283202-5fq1wxz8 214 10 48 48 CD cord-283202-5fq1wxz8 214 11 h h NN cord-283202-5fq1wxz8 214 12 of of IN cord-283202-5fq1wxz8 214 13 initiation initiation NN cord-283202-5fq1wxz8 214 14 of of IN cord-283202-5fq1wxz8 214 15 treatment treatment NN cord-283202-5fq1wxz8 214 16 . . . cord-283202-5fq1wxz8 215 1 39 39 CD cord-283202-5fq1wxz8 215 2 Cats cat NNS cord-283202-5fq1wxz8 215 3 with with IN cord-283202-5fq1wxz8 215 4 systemic systemic JJ cord-283202-5fq1wxz8 215 5 or or CC cord-283202-5fq1wxz8 215 6 ocular ocular JJ cord-283202-5fq1wxz8 215 7 disease disease NN cord-283202-5fq1wxz8 215 8 treated treat VBN cord-283202-5fq1wxz8 215 9 with with IN cord-283202-5fq1wxz8 215 10 antibiotic antibiotic JJ cord-283202-5fq1wxz8 215 11 therapy therapy NN cord-283202-5fq1wxz8 215 12 may may MD cord-283202-5fq1wxz8 215 13 achieve achieve VB cord-283202-5fq1wxz8 215 14 clinical clinical JJ cord-283202-5fq1wxz8 215 15 remission remission NN cord-283202-5fq1wxz8 215 16 ; ; : cord-283202-5fq1wxz8 215 17 however however RB cord-283202-5fq1wxz8 215 18 , , , cord-283202-5fq1wxz8 215 19 recurrence recurrence NN cord-283202-5fq1wxz8 215 20 of of IN cord-283202-5fq1wxz8 215 21 signs sign NNS cord-283202-5fq1wxz8 215 22 is be VBZ cord-283202-5fq1wxz8 215 23 likely likely JJ cord-283202-5fq1wxz8 215 24 as as IN cord-283202-5fq1wxz8 215 25 antibiotic antibiotic JJ cord-283202-5fq1wxz8 215 26 therapy therapy NN cord-283202-5fq1wxz8 215 27 is be VBZ cord-283202-5fq1wxz8 215 28 unlikely unlikely JJ cord-283202-5fq1wxz8 215 29 to to TO cord-283202-5fq1wxz8 215 30 eliminate eliminate VB cord-283202-5fq1wxz8 215 31 the the DT cord-283202-5fq1wxz8 215 32 organism organism NN cord-283202-5fq1wxz8 215 33 entirely entirely RB cord-283202-5fq1wxz8 215 34 . . . cord-283202-5fq1wxz8 216 1 42 42 CD cord-283202-5fq1wxz8 216 2 Chronic chronic JJ cord-283202-5fq1wxz8 216 3 systemic systemic JJ cord-283202-5fq1wxz8 216 4 hypertension hypertension NN cord-283202-5fq1wxz8 216 5 has have VBZ cord-283202-5fq1wxz8 216 6 a a DT cord-283202-5fq1wxz8 216 7 variety variety NN cord-283202-5fq1wxz8 216 8 of of IN cord-283202-5fq1wxz8 216 9 pathological pathological JJ cord-283202-5fq1wxz8 216 10 consequences consequence NNS cord-283202-5fq1wxz8 216 11 that that WDT cord-283202-5fq1wxz8 216 12 collectively collectively RB cord-283202-5fq1wxz8 216 13 are be VBP cord-283202-5fq1wxz8 216 14 referred refer VBN cord-283202-5fq1wxz8 216 15 to to IN cord-283202-5fq1wxz8 216 16 as as RB cord-283202-5fq1wxz8 216 17 end end NN cord-283202-5fq1wxz8 216 18 - - HYPH cord-283202-5fq1wxz8 216 19 organ organ NN cord-283202-5fq1wxz8 216 20 or or CC cord-283202-5fq1wxz8 216 21 target target NN cord-283202-5fq1wxz8 216 22 organ organ NN cord-283202-5fq1wxz8 216 23 damage damage NN cord-283202-5fq1wxz8 216 24 . . . cord-283202-5fq1wxz8 217 1 Important important JJ cord-283202-5fq1wxz8 217 2 target target NN cord-283202-5fq1wxz8 217 3 organ organ NN cord-283202-5fq1wxz8 217 4 damage damage NN cord-283202-5fq1wxz8 217 5 is be VBZ cord-283202-5fq1wxz8 217 6 observed observe VBN cord-283202-5fq1wxz8 217 7 in in IN cord-283202-5fq1wxz8 217 8 the the DT cord-283202-5fq1wxz8 217 9 kidneys kidney NNS cord-283202-5fq1wxz8 217 10 , , , cord-283202-5fq1wxz8 217 11 eyes eye NNS cord-283202-5fq1wxz8 217 12 , , , cord-283202-5fq1wxz8 217 13 heart heart NN cord-283202-5fq1wxz8 217 14 and and CC cord-283202-5fq1wxz8 217 15 nervous nervous JJ cord-283202-5fq1wxz8 217 16 system system NN cord-283202-5fq1wxz8 217 17 . . . cord-283202-5fq1wxz8 218 1 90 90 CD cord-283202-5fq1wxz8 219 1 In in IN cord-283202-5fq1wxz8 219 2 the the DT cord-283202-5fq1wxz8 219 3 kidney kidney NN cord-283202-5fq1wxz8 219 4 , , , cord-283202-5fq1wxz8 219 5 this this DT cord-283202-5fq1wxz8 219 6 leads lead VBZ cord-283202-5fq1wxz8 219 7 to to IN cord-283202-5fq1wxz8 219 8 an an DT cord-283202-5fq1wxz8 219 9 accelerated accelerated JJ cord-283202-5fq1wxz8 219 10 decline decline NN cord-283202-5fq1wxz8 219 11 in in IN cord-283202-5fq1wxz8 219 12 renal renal JJ cord-283202-5fq1wxz8 219 13 function function NN cord-283202-5fq1wxz8 219 14 , , , cord-283202-5fq1wxz8 219 15 proteinuria proteinuria NN cord-283202-5fq1wxz8 219 16 and and CC cord-283202-5fq1wxz8 219 17 death death NN cord-283202-5fq1wxz8 219 18 . . . cord-283202-5fq1wxz8 220 1 Hypertension hypertension NN cord-283202-5fq1wxz8 220 2 can can MD cord-283202-5fq1wxz8 220 3 exist exist VB cord-283202-5fq1wxz8 220 4 in in IN cord-283202-5fq1wxz8 220 5 animals animal NNS cord-283202-5fq1wxz8 220 6 at at IN cord-283202-5fq1wxz8 220 7 any any DT cord-283202-5fq1wxz8 220 8 stage stage NN cord-283202-5fq1wxz8 220 9 of of IN cord-283202-5fq1wxz8 220 10 renal renal JJ cord-283202-5fq1wxz8 220 11 disease disease NN cord-283202-5fq1wxz8 220 12 , , , cord-283202-5fq1wxz8 220 13 and and CC cord-283202-5fq1wxz8 220 14 may may MD cord-283202-5fq1wxz8 220 15 be be VB cord-283202-5fq1wxz8 220 16 seen see VBN cord-283202-5fq1wxz8 220 17 in in IN cord-283202-5fq1wxz8 220 18 nonazotemic nonazotemic JJ cord-283202-5fq1wxz8 220 19 animals animal NNS cord-283202-5fq1wxz8 220 20 . . . cord-283202-5fq1wxz8 221 1 75 75 CD cord-283202-5fq1wxz8 222 1 In in IN cord-283202-5fq1wxz8 222 2 the the DT cord-283202-5fq1wxz8 222 3 eye eye NN cord-283202-5fq1wxz8 222 4 , , , cord-283202-5fq1wxz8 222 5 hypertension hypertension NN cord-283202-5fq1wxz8 222 6 leads lead VBZ cord-283202-5fq1wxz8 222 7 to to IN cord-283202-5fq1wxz8 222 8 hypertensive hypertensive JJ cord-283202-5fq1wxz8 222 9 retinopathy retinopathy NN cord-283202-5fq1wxz8 222 10 and and CC cord-283202-5fq1wxz8 222 11 choroidopathy choroidopathy NNP cord-283202-5fq1wxz8 222 12 ( ( -LRB- cord-283202-5fq1wxz8 222 13 Fig Fig NNP cord-283202-5fq1wxz8 222 14 3 3 CD cord-283202-5fq1wxz8 222 15 ) ) -RRB- cord-283202-5fq1wxz8 222 16 . . . cord-283202-5fq1wxz8 223 1 Exudative exudative JJ cord-283202-5fq1wxz8 223 2 retinal retinal JJ cord-283202-5fq1wxz8 223 3 detachment detachment NN cord-283202-5fq1wxz8 223 4 , , , cord-283202-5fq1wxz8 223 5 retinal retinal JJ cord-283202-5fq1wxz8 223 6 hemorrhage hemorrhage NN cord-283202-5fq1wxz8 223 7 , , , cord-283202-5fq1wxz8 223 8 multifocal multifocal JJ cord-283202-5fq1wxz8 223 9 retinal retinal JJ cord-283202-5fq1wxz8 223 10 edema edema NN cord-283202-5fq1wxz8 223 11 and and CC cord-283202-5fq1wxz8 223 12 tortuosity tortuosity NN cord-283202-5fq1wxz8 223 13 of of IN cord-283202-5fq1wxz8 223 14 the the DT cord-283202-5fq1wxz8 223 15 retinal retinal JJ cord-283202-5fq1wxz8 223 16 vessels vessel NNS cord-283202-5fq1wxz8 223 17 may may MD cord-283202-5fq1wxz8 223 18 be be VB cord-283202-5fq1wxz8 223 19 observed observe VBN cord-283202-5fq1wxz8 223 20 , , , cord-283202-5fq1wxz8 223 21 and and CC cord-283202-5fq1wxz8 223 22 commonly commonly RB cord-283202-5fq1wxz8 223 23 result result VB cord-283202-5fq1wxz8 223 24 in in IN cord-283202-5fq1wxz8 223 25 blindness blindness NN cord-283202-5fq1wxz8 223 26 . . . cord-283202-5fq1wxz8 224 1 74 74 CD cord-283202-5fq1wxz8 224 2 , , , cord-283202-5fq1wxz8 224 3 82 82 CD cord-283202-5fq1wxz8 224 4 , , , cord-283202-5fq1wxz8 224 5 83 83 CD cord-283202-5fq1wxz8 224 6 , , , cord-283202-5fq1wxz8 224 7 89 89 CD cord-283202-5fq1wxz8 224 8 , , , cord-283202-5fq1wxz8 224 9 [ [ -LRB- cord-283202-5fq1wxz8 224 10 91 91 CD cord-283202-5fq1wxz8 224 11 ] ] -RRB- cord-283202-5fq1wxz8 224 12 [ [ -LRB- cord-283202-5fq1wxz8 224 13 92 92 CD cord-283202-5fq1wxz8 224 14 ] ] -RRB- cord-283202-5fq1wxz8 225 1 [ [ -LRB- cord-283202-5fq1wxz8 225 2 93 93 CD cord-283202-5fq1wxz8 225 3 ] ] -RRB- cord-283202-5fq1wxz8 226 1 In in IN cord-283202-5fq1wxz8 226 2 the the DT cord-283202-5fq1wxz8 226 3 heart heart NN cord-283202-5fq1wxz8 226 4 , , , cord-283202-5fq1wxz8 226 5 hypertension hypertension NN cord-283202-5fq1wxz8 226 6 may may MD cord-283202-5fq1wxz8 226 7 result result VB cord-283202-5fq1wxz8 226 8 in in IN cord-283202-5fq1wxz8 226 9 cardiomegaly cardiomegaly NN cord-283202-5fq1wxz8 226 10 and and CC cord-283202-5fq1wxz8 226 11 left leave VBN cord-283202-5fq1wxz8 226 12 ventricular ventricular JJ cord-283202-5fq1wxz8 226 13 hypertrophy hypertrophy NN cord-283202-5fq1wxz8 226 14 . . . cord-283202-5fq1wxz8 227 1 74 74 CD cord-283202-5fq1wxz8 227 2 , , , cord-283202-5fq1wxz8 227 3 83 83 CD cord-283202-5fq1wxz8 227 4 , , , cord-283202-5fq1wxz8 227 5 89 89 CD cord-283202-5fq1wxz8 227 6 , , , cord-283202-5fq1wxz8 227 7 94 94 CD cord-283202-5fq1wxz8 227 8 A a DT cord-283202-5fq1wxz8 227 9 systolic systolic JJ cord-283202-5fq1wxz8 227 10 murmur murmur NN cord-283202-5fq1wxz8 227 11 , , , cord-283202-5fq1wxz8 227 12 gallop gallop VB cord-283202-5fq1wxz8 227 13 rhythm rhythm NN cord-283202-5fq1wxz8 227 14 and and CC cord-283202-5fq1wxz8 227 15 congestive congestive JJ cord-283202-5fq1wxz8 227 16 heart heart NN cord-283202-5fq1wxz8 227 17 failure failure NN cord-283202-5fq1wxz8 227 18 may may MD cord-283202-5fq1wxz8 227 19 be be VB cord-283202-5fq1wxz8 227 20 observed observe VBN cord-283202-5fq1wxz8 227 21 . . . cord-283202-5fq1wxz8 228 1 82 82 CD cord-283202-5fq1wxz8 229 1 , , , cord-283202-5fq1wxz8 229 2 89 89 CD cord-283202-5fq1wxz8 230 1 In in IN cord-283202-5fq1wxz8 230 2 the the DT cord-283202-5fq1wxz8 230 3 nervous nervous JJ cord-283202-5fq1wxz8 230 4 system system NN cord-283202-5fq1wxz8 230 5 , , , cord-283202-5fq1wxz8 230 6 hypertension hypertension NN cord-283202-5fq1wxz8 230 7 may may MD cord-283202-5fq1wxz8 230 8 result result VB cord-283202-5fq1wxz8 230 9 in in IN cord-283202-5fq1wxz8 230 10 a a DT cord-283202-5fq1wxz8 230 11 hypertensive hypertensive JJ cord-283202-5fq1wxz8 230 12 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 230 13 . . . cord-283202-5fq1wxz8 231 1 83 83 CD cord-283202-5fq1wxz8 231 2 , , , cord-283202-5fq1wxz8 231 3 85 85 CD cord-283202-5fq1wxz8 231 4 , , , cord-283202-5fq1wxz8 231 5 86 86 CD cord-283202-5fq1wxz8 231 6 , , , cord-283202-5fq1wxz8 231 7 89 89 CD cord-283202-5fq1wxz8 231 8 , , , cord-283202-5fq1wxz8 231 9 95 95 CD cord-283202-5fq1wxz8 231 10 Two two CD cord-283202-5fq1wxz8 231 11 studies study NNS cord-283202-5fq1wxz8 231 12 have have VBP cord-283202-5fq1wxz8 231 13 variously variously RB cord-283202-5fq1wxz8 231 14 documented document VBN cord-283202-5fq1wxz8 231 15 neurological neurological JJ cord-283202-5fq1wxz8 231 16 signs sign NNS cord-283202-5fq1wxz8 231 17 in in IN cord-283202-5fq1wxz8 231 18 29 29 CD cord-283202-5fq1wxz8 231 19 % % NN cord-283202-5fq1wxz8 231 20 and and CC cord-283202-5fq1wxz8 231 21 46 46 CD cord-283202-5fq1wxz8 231 22 % % NN cord-283202-5fq1wxz8 231 23 of of IN cord-283202-5fq1wxz8 231 24 cats cat NNS cord-283202-5fq1wxz8 231 25 with with IN cord-283202-5fq1wxz8 231 26 hypertension hypertension NN cord-283202-5fq1wxz8 231 27 . . . cord-283202-5fq1wxz8 232 1 83 83 CD cord-283202-5fq1wxz8 232 2 , , , cord-283202-5fq1wxz8 232 3 89 89 CD cord-283202-5fq1wxz8 232 4 Clinical clinical JJ cord-283202-5fq1wxz8 232 5 signs sign NNS cord-283202-5fq1wxz8 232 6 Since since IN cord-283202-5fq1wxz8 232 7 hypertension hypertension NN cord-283202-5fq1wxz8 232 8 in in IN cord-283202-5fq1wxz8 232 9 most most JJS cord-283202-5fq1wxz8 232 10 cats cat NNS cord-283202-5fq1wxz8 232 11 can can MD cord-283202-5fq1wxz8 232 12 be be VB cord-283202-5fq1wxz8 232 13 cat cat NN cord-283202-5fq1wxz8 232 14 egorized egorize VBN cord-283202-5fq1wxz8 232 15 as as IN cord-283202-5fq1wxz8 232 16 secondary secondary JJ cord-283202-5fq1wxz8 232 17 , , , cord-283202-5fq1wxz8 232 18 clinical clinical JJ cord-283202-5fq1wxz8 232 19 signs sign NNS cord-283202-5fq1wxz8 232 20 typically typically RB cord-283202-5fq1wxz8 232 21 reflect reflect VBP cord-283202-5fq1wxz8 232 22 the the DT cord-283202-5fq1wxz8 232 23 underlying underlie VBG cord-283202-5fq1wxz8 232 24 disease disease NN cord-283202-5fq1wxz8 232 25 process process NN cord-283202-5fq1wxz8 232 26 . . . cord-283202-5fq1wxz8 233 1 Consequently consequently RB cord-283202-5fq1wxz8 233 2 , , , cord-283202-5fq1wxz8 233 3 affected affected JJ cord-283202-5fq1wxz8 233 4 cats cat NNS cord-283202-5fq1wxz8 233 5 often often RB cord-283202-5fq1wxz8 233 6 demonstrate demonstrate VBP cord-283202-5fq1wxz8 233 7 signs sign NNS cord-283202-5fq1wxz8 233 8 relating relate VBG cord-283202-5fq1wxz8 233 9 to to IN cord-283202-5fq1wxz8 233 10 renal renal JJ cord-283202-5fq1wxz8 233 11 disease disease NN cord-283202-5fq1wxz8 233 12 or or CC cord-283202-5fq1wxz8 233 13 hyperthyroidism hyperthyroidism NN cord-283202-5fq1wxz8 233 14 , , , cord-283202-5fq1wxz8 233 15 given give VBN cord-283202-5fq1wxz8 233 16 the the DT cord-283202-5fq1wxz8 233 17 high high JJ cord-283202-5fq1wxz8 233 18 prevalence prevalence NN cord-283202-5fq1wxz8 233 19 of of IN cord-283202-5fq1wxz8 233 20 hypertension hypertension NN cord-283202-5fq1wxz8 233 21 with with IN cord-283202-5fq1wxz8 233 22 these these DT cord-283202-5fq1wxz8 233 23 disorders disorder NNS cord-283202-5fq1wxz8 233 24 . . . cord-283202-5fq1wxz8 234 1 Although although IN cord-283202-5fq1wxz8 234 2 the the DT cord-283202-5fq1wxz8 234 3 pathophysiology pathophysiology NN cord-283202-5fq1wxz8 234 4 underlying underlie VBG cord-283202-5fq1wxz8 234 5 hypertensive hypertensive JJ cord-283202-5fq1wxz8 234 6 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 234 7 remains remain VBZ cord-283202-5fq1wxz8 234 8 unclear unclear JJ cord-283202-5fq1wxz8 234 9 , , , cord-283202-5fq1wxz8 234 10 it -PRON- PRP cord-283202-5fq1wxz8 234 11 is be VBZ cord-283202-5fq1wxz8 234 12 thought think VBN cord-283202-5fq1wxz8 234 13 to to TO cord-283202-5fq1wxz8 234 14 involve involve VB cord-283202-5fq1wxz8 234 15 the the DT cord-283202-5fq1wxz8 234 16 development development NN cord-283202-5fq1wxz8 234 17 of of IN cord-283202-5fq1wxz8 234 18 vasogenic vasogenic NNP cord-283202-5fq1wxz8 234 19 edema edema NN cord-283202-5fq1wxz8 234 20 , , , cord-283202-5fq1wxz8 234 21 which which WDT cord-283202-5fq1wxz8 234 22 predominantly predominantly RB cord-283202-5fq1wxz8 234 23 affects affect VBZ cord-283202-5fq1wxz8 234 24 the the DT cord-283202-5fq1wxz8 234 25 white white JJ cord-283202-5fq1wxz8 234 26 matter matter NN cord-283202-5fq1wxz8 234 27 . . . cord-283202-5fq1wxz8 235 1 96 96 CD cord-283202-5fq1wxz8 235 2 , , , cord-283202-5fq1wxz8 235 3 97 97 CD cord-283202-5fq1wxz8 235 4 With with IN cord-283202-5fq1wxz8 235 5 acute acute JJ cord-283202-5fq1wxz8 235 6 hypertension hypertension NN cord-283202-5fq1wxz8 235 7 , , , cord-283202-5fq1wxz8 235 8 the the DT cord-283202-5fq1wxz8 235 9 autoregulatory autoregulatory NNP cord-283202-5fq1wxz8 235 10 capacity capacity NN cord-283202-5fq1wxz8 235 11 of of IN cord-283202-5fq1wxz8 235 12 the the DT cord-283202-5fq1wxz8 235 13 brain brain NN cord-283202-5fq1wxz8 235 14 vasculature vasculature NN cord-283202-5fq1wxz8 235 15 may may MD cord-283202-5fq1wxz8 235 16 be be VB cord-283202-5fq1wxz8 235 17 exceeded exceed VBN cord-283202-5fq1wxz8 235 18 , , , cord-283202-5fq1wxz8 235 19 leading lead VBG cord-283202-5fq1wxz8 235 20 to to IN cord-283202-5fq1wxz8 235 21 hyperperfusion hyperperfusion NN cord-283202-5fq1wxz8 235 22 , , , cord-283202-5fq1wxz8 235 23 breakdown breakdown NN cord-283202-5fq1wxz8 235 24 of of IN cord-283202-5fq1wxz8 235 25 the the DT cord-283202-5fq1wxz8 235 26 blood blood NN cord-283202-5fq1wxz8 235 27 - - HYPH cord-283202-5fq1wxz8 235 28 brain brain NN cord-283202-5fq1wxz8 235 29 barrier barrier NN cord-283202-5fq1wxz8 235 30 , , , cord-283202-5fq1wxz8 235 31 and and CC cord-283202-5fq1wxz8 235 32 cerebral cerebral JJ cord-283202-5fq1wxz8 235 33 edema edema NN cord-283202-5fq1wxz8 235 34 . . . cord-283202-5fq1wxz8 236 1 96 96 CD cord-283202-5fq1wxz8 236 2 , , , cord-283202-5fq1wxz8 236 3 98 98 CD cord-283202-5fq1wxz8 237 1 In in IN cord-283202-5fq1wxz8 237 2 experimental experimental JJ cord-283202-5fq1wxz8 237 3 acute acute JJ cord-283202-5fq1wxz8 237 4 hypertension hypertension NN cord-283202-5fq1wxz8 237 5 in in IN cord-283202-5fq1wxz8 237 6 cats cat NNS cord-283202-5fq1wxz8 237 7 , , , cord-283202-5fq1wxz8 237 8 gross gross JJ cord-283202-5fq1wxz8 237 9 findings finding NNS cord-283202-5fq1wxz8 237 10 include include VBP cord-283202-5fq1wxz8 237 11 coning cone VBG cord-283202-5fq1wxz8 237 12 of of IN cord-283202-5fq1wxz8 237 13 the the DT cord-283202-5fq1wxz8 237 14 vermis vermis NN cord-283202-5fq1wxz8 237 15 of of IN cord-283202-5fq1wxz8 237 16 the the DT cord-283202-5fq1wxz8 237 17 cerebellum cerebellum NN cord-283202-5fq1wxz8 237 18 , , , cord-283202-5fq1wxz8 237 19 cerebel cerebel NNP cord-283202-5fq1wxz8 237 20 - - HYPH cord-283202-5fq1wxz8 237 21 lar lar NNP cord-283202-5fq1wxz8 237 22 herniation herniation NN cord-283202-5fq1wxz8 237 23 into into IN cord-283202-5fq1wxz8 237 24 the the DT cord-283202-5fq1wxz8 237 25 foramen foramen NNP cord-283202-5fq1wxz8 237 26 magnum magnum NN cord-283202-5fq1wxz8 237 27 ( ( -LRB- cord-283202-5fq1wxz8 237 28 Fig Fig NNP cord-283202-5fq1wxz8 237 29 4 4 CD cord-283202-5fq1wxz8 237 30 ) ) -RRB- cord-283202-5fq1wxz8 237 31 , , , cord-283202-5fq1wxz8 237 32 rostral rostral JJ cord-283202-5fq1wxz8 237 33 displacement displacement NN cord-283202-5fq1wxz8 237 34 of of IN cord-283202-5fq1wxz8 237 35 the the DT cord-283202-5fq1wxz8 237 36 colliculi colliculi NNP cord-283202-5fq1wxz8 237 37 , , , cord-283202-5fq1wxz8 237 38 and and CC cord-283202-5fq1wxz8 237 39 widening widen VBG cord-283202-5fq1wxz8 237 40 and and CC cord-283202-5fq1wxz8 237 41 flattening flattening NN cord-283202-5fq1wxz8 237 42 of of IN cord-283202-5fq1wxz8 237 43 the the DT cord-283202-5fq1wxz8 237 44 cerebral cerebral JJ cord-283202-5fq1wxz8 237 45 gyri gyrus NNS cord-283202-5fq1wxz8 237 46 , , , cord-283202-5fq1wxz8 237 47 all all DT cord-283202-5fq1wxz8 237 48 of of IN cord-283202-5fq1wxz8 237 49 which which WDT cord-283202-5fq1wxz8 237 50 reflect reflect VBP cord-283202-5fq1wxz8 237 51 raised raise VBN cord-283202-5fq1wxz8 237 52 intracranial intracranial JJ cord-283202-5fq1wxz8 237 53 pressure pressure NN cord-283202-5fq1wxz8 237 54 . . . cord-283202-5fq1wxz8 238 1 95 95 CD cord-283202-5fq1wxz8 238 2 Microscopically microscopically RB cord-283202-5fq1wxz8 238 3 , , , cord-283202-5fq1wxz8 238 4 the the DT cord-283202-5fq1wxz8 238 5 consequences consequence NNS cord-283202-5fq1wxz8 238 6 of of IN cord-283202-5fq1wxz8 238 7 edema edema NN cord-283202-5fq1wxz8 238 8 are be VBP cord-283202-5fq1wxz8 238 9 observed observe VBN cord-283202-5fq1wxz8 238 10 such such JJ cord-283202-5fq1wxz8 238 11 as as IN cord-283202-5fq1wxz8 238 12 marked marked JJ cord-283202-5fq1wxz8 238 13 pallor pallor NN cord-283202-5fq1wxz8 238 14 of of IN cord-283202-5fq1wxz8 238 15 the the DT cord-283202-5fq1wxz8 238 16 cerebral cerebral JJ cord-283202-5fq1wxz8 238 17 white white JJ cord-283202-5fq1wxz8 238 18 matter matter NN cord-283202-5fq1wxz8 238 19 , , , cord-283202-5fq1wxz8 238 20 accentuation accentuation NN cord-283202-5fq1wxz8 238 21 of of IN cord-283202-5fq1wxz8 238 22 the the DT cord-283202-5fq1wxz8 238 23 separation separation NN cord-283202-5fq1wxz8 238 24 between between IN cord-283202-5fq1wxz8 238 25 axons axon NNS cord-283202-5fq1wxz8 238 26 and and CC cord-283202-5fq1wxz8 238 27 myelin myelin NN cord-283202-5fq1wxz8 238 28 sheaths sheath NNS cord-283202-5fq1wxz8 238 29 , , , cord-283202-5fq1wxz8 238 30 and and CC cord-283202-5fq1wxz8 238 31 widening widen VBG cord-283202-5fq1wxz8 238 32 of of IN cord-283202-5fq1wxz8 238 33 the the DT cord-283202-5fq1wxz8 238 34 perivascular perivascular JJ cord-283202-5fq1wxz8 238 35 space space NN cord-283202-5fq1wxz8 238 36 . . . cord-283202-5fq1wxz8 239 1 95 95 CD cord-283202-5fq1wxz8 240 1 In in IN cord-283202-5fq1wxz8 240 2 chronic chronic JJ cord-283202-5fq1wxz8 240 3 hypertension hypertension NN cord-283202-5fq1wxz8 240 4 , , , cord-283202-5fq1wxz8 240 5 brain brain NN cord-283202-5fq1wxz8 240 6 vasculature vasculature NN cord-283202-5fq1wxz8 240 7 may may MD cord-283202-5fq1wxz8 240 8 be be VB cord-283202-5fq1wxz8 240 9 chronically chronically RB cord-283202-5fq1wxz8 240 10 vasoconstricted vasoconstricte VBN cord-283202-5fq1wxz8 240 11 leading lead VBG cord-283202-5fq1wxz8 240 12 to to IN cord-283202-5fq1wxz8 240 13 hypertrophy hypertrophy NN cord-283202-5fq1wxz8 240 14 and and CC cord-283202-5fq1wxz8 240 15 hyperplasia hyperplasia NN cord-283202-5fq1wxz8 240 16 of of IN cord-283202-5fq1wxz8 240 17 the the DT cord-283202-5fq1wxz8 240 18 smooth smooth JJ cord-283202-5fq1wxz8 240 19 muscle muscle NN cord-283202-5fq1wxz8 240 20 . . . cord-283202-5fq1wxz8 241 1 89 89 CD cord-283202-5fq1wxz8 242 1 As as IN cord-283202-5fq1wxz8 242 2 a a DT cord-283202-5fq1wxz8 242 3 result result NN cord-283202-5fq1wxz8 242 4 , , , cord-283202-5fq1wxz8 242 5 fibrous fibrous JJ cord-283202-5fq1wxz8 242 6 changes change NNS cord-283202-5fq1wxz8 242 7 develop develop VBP cord-283202-5fq1wxz8 242 8 , , , cord-283202-5fq1wxz8 242 9 allowing allow VBG cord-283202-5fq1wxz8 242 10 leakage leakage NN cord-283202-5fq1wxz8 242 11 of of IN cord-283202-5fq1wxz8 242 12 plasma plasma NN cord-283202-5fq1wxz8 242 13 which which WDT cord-283202-5fq1wxz8 242 14 ultimately ultimately RB cord-283202-5fq1wxz8 242 15 causes cause VBZ cord-283202-5fq1wxz8 242 16 degeneration degeneration NN cord-283202-5fq1wxz8 242 17 of of IN cord-283202-5fq1wxz8 242 18 the the DT cord-283202-5fq1wxz8 242 19 vasculature vasculature NN cord-283202-5fq1wxz8 242 20 predisposing predispose VBG cord-283202-5fq1wxz8 242 21 to to IN cord-283202-5fq1wxz8 242 22 ruptures rupture NNS cord-283202-5fq1wxz8 242 23 and and CC cord-283202-5fq1wxz8 242 24 microhemorrhages microhemorrhage NNS cord-283202-5fq1wxz8 242 25 . . . cord-283202-5fq1wxz8 243 1 89 89 CD cord-283202-5fq1wxz8 243 2 Multifocal multifocal JJ cord-283202-5fq1wxz8 243 3 cerebral cerebral JJ cord-283202-5fq1wxz8 243 4 arteriosclerosis arteriosclerosis NN cord-283202-5fq1wxz8 243 5 with with IN cord-283202-5fq1wxz8 243 6 hemorrhages hemorrhage NNS cord-283202-5fq1wxz8 243 7 has have VBZ cord-283202-5fq1wxz8 243 8 been be VBN cord-283202-5fq1wxz8 243 9 observed observe VBN cord-283202-5fq1wxz8 243 10 in in IN cord-283202-5fq1wxz8 243 11 cats cat NNS cord-283202-5fq1wxz8 243 12 with with IN cord-283202-5fq1wxz8 243 13 spontaneous spontaneous JJ cord-283202-5fq1wxz8 243 14 hypertension hypertension NN cord-283202-5fq1wxz8 243 15 . . . cord-283202-5fq1wxz8 244 1 83 83 CD cord-283202-5fq1wxz8 245 1 A a DT cord-283202-5fq1wxz8 245 2 presumptive presumptive JJ cord-283202-5fq1wxz8 245 3 diagnosis diagnosis NN cord-283202-5fq1wxz8 245 4 of of IN cord-283202-5fq1wxz8 245 5 hypertensive hypertensive JJ cord-283202-5fq1wxz8 245 6 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 245 7 is be VBZ cord-283202-5fq1wxz8 245 8 relatively relatively RB cord-283202-5fq1wxz8 245 9 straightforward straightforward JJ cord-283202-5fq1wxz8 245 10 and and CC cord-283202-5fq1wxz8 245 11 requires require VBZ cord-283202-5fq1wxz8 245 12 the the DT cord-283202-5fq1wxz8 245 13 documentation documentation NN cord-283202-5fq1wxz8 245 14 of of IN cord-283202-5fq1wxz8 245 15 hypertension hypertension NN cord-283202-5fq1wxz8 245 16 ( ( -LRB- cord-283202-5fq1wxz8 245 17 systolic systolic JJ cord-283202-5fq1wxz8 245 18 blood blood NN cord-283202-5fq1wxz8 245 19 pressure pressure NN cord-283202-5fq1wxz8 245 20 ≥ ≥ CD cord-283202-5fq1wxz8 245 21 160 160 CD cord-283202-5fq1wxz8 245 22 - - SYM cord-283202-5fq1wxz8 245 23 170 170 CD cord-283202-5fq1wxz8 245 24 mmHg mmHg NNS cord-283202-5fq1wxz8 245 25 ) ) -RRB- cord-283202-5fq1wxz8 245 26 with with IN cord-283202-5fq1wxz8 245 27 contemporaneous contemporaneous JJ cord-283202-5fq1wxz8 245 28 neurological neurological JJ cord-283202-5fq1wxz8 245 29 signs sign NNS cord-283202-5fq1wxz8 245 30 . . . cord-283202-5fq1wxz8 246 1 The the DT cord-283202-5fq1wxz8 246 2 gold gold NN cord-283202-5fq1wxz8 246 3 standard standard NN cord-283202-5fq1wxz8 246 4 for for IN cord-283202-5fq1wxz8 246 5 blood blood NN cord-283202-5fq1wxz8 246 6 pressure pressure NN cord-283202-5fq1wxz8 246 7 measurement measurement NN cord-283202-5fq1wxz8 246 8 is be VBZ cord-283202-5fq1wxz8 246 9 invasive invasive JJ cord-283202-5fq1wxz8 246 10 intra intra JJ cord-283202-5fq1wxz8 246 11 - - JJ cord-283202-5fq1wxz8 246 12 arterial arterial JJ cord-283202-5fq1wxz8 246 13 monitoring monitoring NN cord-283202-5fq1wxz8 246 14 . . . cord-283202-5fq1wxz8 247 1 However however RB cord-283202-5fq1wxz8 247 2 , , , cord-283202-5fq1wxz8 247 3 this this DT cord-283202-5fq1wxz8 247 4 is be VBZ cord-283202-5fq1wxz8 247 5 often often RB cord-283202-5fq1wxz8 247 6 not not RB cord-283202-5fq1wxz8 247 7 feasible feasible JJ cord-283202-5fq1wxz8 247 8 in in IN cord-283202-5fq1wxz8 247 9 clinical clinical JJ cord-283202-5fq1wxz8 247 10 practice practice NN cord-283202-5fq1wxz8 247 11 . . . cord-283202-5fq1wxz8 248 1 99 99 CD cord-283202-5fq1wxz8 249 1 Consequently consequently RB cord-283202-5fq1wxz8 249 2 , , , cord-283202-5fq1wxz8 249 3 indirect indirect JJ cord-283202-5fq1wxz8 249 4 blood blood NN cord-283202-5fq1wxz8 249 5 pressure pressure NN cord-283202-5fq1wxz8 249 6 monitoring monitoring NN cord-283202-5fq1wxz8 249 7 is be VBZ cord-283202-5fq1wxz8 249 8 used use VBN cord-283202-5fq1wxz8 249 9 most most RBS cord-283202-5fq1wxz8 249 10 commonly commonly RB cord-283202-5fq1wxz8 249 11 . . . cord-283202-5fq1wxz8 250 1 99 99 CD cord-283202-5fq1wxz8 250 2 Accurate accurate JJ cord-283202-5fq1wxz8 250 3 and and CC cord-283202-5fq1wxz8 250 4 reliable reliable JJ cord-283202-5fq1wxz8 250 5 indirect indirect JJ cord-283202-5fq1wxz8 250 6 blood blood NN cord-283202-5fq1wxz8 250 7 pressure pressure NN cord-283202-5fq1wxz8 250 8 measurements measurement NNS cord-283202-5fq1wxz8 250 9 can can MD cord-283202-5fq1wxz8 250 10 be be VB cord-283202-5fq1wxz8 250 11 performed perform VBN cord-283202-5fq1wxz8 250 12 using use VBG cord-283202-5fq1wxz8 250 13 Doppler Doppler NNP cord-283202-5fq1wxz8 250 14 flow flow NN cord-283202-5fq1wxz8 250 15 ultrasonography ultrasonography NN cord-283202-5fq1wxz8 250 16 and and CC cord-283202-5fq1wxz8 250 17 oscillometry oscillometry NN cord-283202-5fq1wxz8 250 18 . . . cord-283202-5fq1wxz8 251 1 99 99 CD cord-283202-5fq1wxz8 251 2 Minimal minimal JJ cord-283202-5fq1wxz8 251 3 , , , cord-283202-5fq1wxz8 251 4 mild mild JJ cord-283202-5fq1wxz8 251 5 , , , cord-283202-5fq1wxz8 251 6 moderate moderate JJ cord-283202-5fq1wxz8 251 7 and and CC cord-283202-5fq1wxz8 251 8 severe severe JJ cord-283202-5fq1wxz8 251 9 risk risk NN cord-283202-5fq1wxz8 251 10 categories category NNS cord-283202-5fq1wxz8 251 11 for for IN cord-283202-5fq1wxz8 251 12 target target NN cord-283202-5fq1wxz8 251 13 organ organ NN cord-283202-5fq1wxz8 251 14 damage damage NN cord-283202-5fq1wxz8 251 15 have have VBP cord-283202-5fq1wxz8 251 16 been be VBN cord-283202-5fq1wxz8 251 17 defined define VBN cord-283202-5fq1wxz8 251 18 based base VBN cord-283202-5fq1wxz8 251 19 on on IN cord-283202-5fq1wxz8 251 20 blood blood NN cord-283202-5fq1wxz8 251 21 pressure pressure NN cord-283202-5fq1wxz8 251 22 recordings recording NNS cord-283202-5fq1wxz8 251 23 ( ( -LRB- cord-283202-5fq1wxz8 251 24 see see VB cord-283202-5fq1wxz8 251 25 below below RB cord-283202-5fq1wxz8 251 26 ) ) -RRB- cord-283202-5fq1wxz8 251 27 . . . cord-283202-5fq1wxz8 252 1 75 75 CD cord-283202-5fq1wxz8 252 2 Identification identification NN cord-283202-5fq1wxz8 252 3 of of IN cord-283202-5fq1wxz8 252 4 hypertension hypertension NN cord-283202-5fq1wxz8 252 5 should should MD cord-283202-5fq1wxz8 252 6 prompt prompt VB cord-283202-5fq1wxz8 252 7 investigation investigation NN cord-283202-5fq1wxz8 252 8 for for IN cord-283202-5fq1wxz8 252 9 an an DT cord-283202-5fq1wxz8 252 10 underlying underlie VBG cord-283202-5fq1wxz8 252 11 disease disease NN cord-283202-5fq1wxz8 252 12 process process NN cord-283202-5fq1wxz8 252 13 . . . cord-283202-5fq1wxz8 253 1 A a DT cord-283202-5fq1wxz8 253 2 complete complete JJ cord-283202-5fq1wxz8 253 3 blood blood NN cord-283202-5fq1wxz8 253 4 count count NN cord-283202-5fq1wxz8 253 5 , , , cord-283202-5fq1wxz8 253 6 biochemistry biochemistry NN cord-283202-5fq1wxz8 253 7 profile profile NN cord-283202-5fq1wxz8 253 8 and and CC cord-283202-5fq1wxz8 253 9 urinalysis urinalysis NN cord-283202-5fq1wxz8 253 10 should should MD cord-283202-5fq1wxz8 253 11 be be VB cord-283202-5fq1wxz8 253 12 performed perform VBN cord-283202-5fq1wxz8 253 13 in in IN cord-283202-5fq1wxz8 253 14 all all DT cord-283202-5fq1wxz8 253 15 hypertensive hypertensive JJ cord-283202-5fq1wxz8 253 16 cats cat NNS cord-283202-5fq1wxz8 253 17 . . . cord-283202-5fq1wxz8 254 1 In in IN cord-283202-5fq1wxz8 254 2 cats cat NNS cord-283202-5fq1wxz8 254 3 older old JJR cord-283202-5fq1wxz8 254 4 than than IN cord-283202-5fq1wxz8 254 5 5 5 CD cord-283202-5fq1wxz8 254 6 years year NNS cord-283202-5fq1wxz8 254 7 of of IN cord-283202-5fq1wxz8 254 8 age age NN cord-283202-5fq1wxz8 254 9 , , , cord-283202-5fq1wxz8 254 10 serum serum NN cord-283202-5fq1wxz8 254 11 thyroxine thyroxine NN cord-283202-5fq1wxz8 254 12 level level NN cord-283202-5fq1wxz8 254 13 should should MD cord-283202-5fq1wxz8 254 14 also also RB cord-283202-5fq1wxz8 254 15 be be VB cord-283202-5fq1wxz8 254 16 measured measure VBN cord-283202-5fq1wxz8 254 17 . . . cord-283202-5fq1wxz8 255 1 When when WRB cord-283202-5fq1wxz8 255 2 indicated indicate VBN cord-283202-5fq1wxz8 255 3 , , , cord-283202-5fq1wxz8 255 4 endocrinological endocrinological JJ cord-283202-5fq1wxz8 255 5 testing testing NN cord-283202-5fq1wxz8 255 6 for for IN cord-283202-5fq1wxz8 255 7 Cushing Cushing NNP cord-283202-5fq1wxz8 255 8 's 's POS cord-283202-5fq1wxz8 255 9 disease disease NN cord-283202-5fq1wxz8 255 10 or or CC cord-283202-5fq1wxz8 255 11 diabetes diabetes NN cord-283202-5fq1wxz8 255 12 mellitus mellitus NN cord-283202-5fq1wxz8 255 13 should should MD cord-283202-5fq1wxz8 255 14 be be VB cord-283202-5fq1wxz8 255 15 performed perform VBN cord-283202-5fq1wxz8 255 16 . . . cord-283202-5fq1wxz8 256 1 In in IN cord-283202-5fq1wxz8 256 2 cats cat NNS cord-283202-5fq1wxz8 256 3 with with IN cord-283202-5fq1wxz8 256 4 suspected suspect VBN cord-283202-5fq1wxz8 256 5 or or CC cord-283202-5fq1wxz8 256 6 confirmed confirm VBN cord-283202-5fq1wxz8 256 7 renal renal JJ cord-283202-5fq1wxz8 256 8 disease disease NN cord-283202-5fq1wxz8 256 9 , , , cord-283202-5fq1wxz8 256 10 quantification quantification NN cord-283202-5fq1wxz8 256 11 of of IN cord-283202-5fq1wxz8 256 12 a a DT cord-283202-5fq1wxz8 256 13 proteinuria proteinuria NN cord-283202-5fq1wxz8 256 14 should should MD cord-283202-5fq1wxz8 256 15 be be VB cord-283202-5fq1wxz8 256 16 performed perform VBN cord-283202-5fq1wxz8 256 17 . . . cord-283202-5fq1wxz8 257 1 Thoracic thoracic JJ cord-283202-5fq1wxz8 257 2 radiographs radiograph NNS cord-283202-5fq1wxz8 257 3 should should MD cord-283202-5fq1wxz8 257 4 be be VB cord-283202-5fq1wxz8 257 5 obtained obtain VBN cord-283202-5fq1wxz8 257 6 to to TO cord-283202-5fq1wxz8 257 7 assess assess VB cord-283202-5fq1wxz8 257 8 cardiovascular cardiovascular JJ cord-283202-5fq1wxz8 257 9 structures structure NNS cord-283202-5fq1wxz8 257 10 , , , cord-283202-5fq1wxz8 257 11 and and CC cord-283202-5fq1wxz8 257 12 abdominal abdominal JJ cord-283202-5fq1wxz8 257 13 ultrasonography ultrasonography NN cord-283202-5fq1wxz8 257 14 should should MD cord-283202-5fq1wxz8 257 15 be be VB cord-283202-5fq1wxz8 257 16 performed perform VBN cord-283202-5fq1wxz8 257 17 to to TO cord-283202-5fq1wxz8 257 18 assess assess VB cord-283202-5fq1wxz8 257 19 renal renal JJ cord-283202-5fq1wxz8 257 20 structure structure NN cord-283202-5fq1wxz8 257 21 and and CC cord-283202-5fq1wxz8 257 22 identify identify VB cord-283202-5fq1wxz8 257 23 any any DT cord-283202-5fq1wxz8 257 24 concurrent concurrent JJ cord-283202-5fq1wxz8 257 25 disease disease NN cord-283202-5fq1wxz8 257 26 . . . cord-283202-5fq1wxz8 258 1 Echocardi Echocardi NNP cord-283202-5fq1wxz8 258 2 ography ography NN cord-283202-5fq1wxz8 258 3 is be VBZ cord-283202-5fq1wxz8 258 4 warranted warrant VBN cord-283202-5fq1wxz8 258 5 in in IN cord-283202-5fq1wxz8 258 6 cats cat NNS cord-283202-5fq1wxz8 258 7 with with IN cord-283202-5fq1wxz8 258 8 a a DT cord-283202-5fq1wxz8 258 9 murmur murmur NN cord-283202-5fq1wxz8 258 10 , , , cord-283202-5fq1wxz8 258 11 gallop gallop VB cord-283202-5fq1wxz8 258 12 rhythm rhythm NN cord-283202-5fq1wxz8 258 13 or or CC cord-283202-5fq1wxz8 258 14 other other JJ cord-283202-5fq1wxz8 258 15 signs sign NNS cord-283202-5fq1wxz8 258 16 consistent consistent JJ cord-283202-5fq1wxz8 258 17 with with IN cord-283202-5fq1wxz8 258 18 cardiac cardiac JJ cord-283202-5fq1wxz8 258 19 disease disease NN cord-283202-5fq1wxz8 258 20 . . . cord-283202-5fq1wxz8 259 1 In in IN cord-283202-5fq1wxz8 259 2 all all DT cord-283202-5fq1wxz8 259 3 cats cat NNS cord-283202-5fq1wxz8 259 4 with with IN cord-283202-5fq1wxz8 259 5 hypertension hypertension NN cord-283202-5fq1wxz8 259 6 , , , cord-283202-5fq1wxz8 259 7 echocardiography echocardiography NN cord-283202-5fq1wxz8 259 8 allows allow VBZ cord-283202-5fq1wxz8 259 9 assessment assessment NN cord-283202-5fq1wxz8 259 10 of of IN cord-283202-5fq1wxz8 259 11 any any DT cord-283202-5fq1wxz8 259 12 secondary secondary JJ cord-283202-5fq1wxz8 259 13 cardiac cardiac JJ cord-283202-5fq1wxz8 259 14 changes change NNS cord-283202-5fq1wxz8 259 15 . . . cord-283202-5fq1wxz8 260 1 In in IN cord-283202-5fq1wxz8 260 2 cats cat NNS cord-283202-5fq1wxz8 260 3 with with IN cord-283202-5fq1wxz8 260 4 severe severe JJ cord-283202-5fq1wxz8 260 5 neurological neurological JJ cord-283202-5fq1wxz8 260 6 dysfunction dysfunction NN cord-283202-5fq1wxz8 260 7 MRI MRI NNP cord-283202-5fq1wxz8 260 8 may may MD cord-283202-5fq1wxz8 260 9 be be VB cord-283202-5fq1wxz8 260 10 warranted warrant VBN cord-283202-5fq1wxz8 260 11 . . . cord-283202-5fq1wxz8 261 1 In in IN cord-283202-5fq1wxz8 261 2 addition addition NN cord-283202-5fq1wxz8 261 3 to to IN cord-283202-5fq1wxz8 261 4 assessing assess VBG cord-283202-5fq1wxz8 261 5 CNS CNS NNP cord-283202-5fq1wxz8 261 6 pathology pathology NN cord-283202-5fq1wxz8 261 7 related relate VBN cord-283202-5fq1wxz8 261 8 to to IN cord-283202-5fq1wxz8 261 9 hypertension hypertension NN cord-283202-5fq1wxz8 261 10 , , , cord-283202-5fq1wxz8 261 11 MRI MRI NNP cord-283202-5fq1wxz8 261 12 allows allow VBZ cord-283202-5fq1wxz8 261 13 exclusion exclusion NN cord-283202-5fq1wxz8 261 14 of of IN cord-283202-5fq1wxz8 261 15 other other JJ cord-283202-5fq1wxz8 261 16 disease disease NN cord-283202-5fq1wxz8 261 17 processes process NNS cord-283202-5fq1wxz8 261 18 that that WDT cord-283202-5fq1wxz8 261 19 can can MD cord-283202-5fq1wxz8 261 20 produce produce VB cord-283202-5fq1wxz8 261 21 similar similar JJ cord-283202-5fq1wxz8 261 22 neurological neurological JJ cord-283202-5fq1wxz8 261 23 signs sign NNS cord-283202-5fq1wxz8 261 24 . . . cord-283202-5fq1wxz8 262 1 Given give VBN cord-283202-5fq1wxz8 262 2 the the DT cord-283202-5fq1wxz8 262 3 potential potential NN cord-283202-5fq1wxz8 262 4 for for IN cord-283202-5fq1wxz8 262 5 raised raise VBN cord-283202-5fq1wxz8 262 6 intracranial intracranial JJ cord-283202-5fq1wxz8 262 7 pressure pressure NN cord-283202-5fq1wxz8 262 8 and and CC cord-283202-5fq1wxz8 262 9 brain brain NN cord-283202-5fq1wxz8 262 10 herniation herniation NN cord-283202-5fq1wxz8 262 11 in in IN cord-283202-5fq1wxz8 262 12 hypertensive hypertensive JJ cord-283202-5fq1wxz8 262 13 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 262 14 , , , cord-283202-5fq1wxz8 262 15 caution caution NN cord-283202-5fq1wxz8 262 16 should should MD cord-283202-5fq1wxz8 262 17 be be VB cord-283202-5fq1wxz8 262 18 exercised exercise VBN cord-283202-5fq1wxz8 262 19 prior prior RB cord-283202-5fq1wxz8 262 20 to to IN cord-283202-5fq1wxz8 262 21 advanced advanced JJ cord-283202-5fq1wxz8 262 22 imaging imaging NN cord-283202-5fq1wxz8 262 23 ; ; : cord-283202-5fq1wxz8 262 24 the the DT cord-283202-5fq1wxz8 262 25 requirement requirement NN cord-283202-5fq1wxz8 262 26 for for IN cord-283202-5fq1wxz8 262 27 general general JJ cord-283202-5fq1wxz8 262 28 anesthesia anesthesia NNP cord-283202-5fq1wxz8 262 29 can can MD cord-283202-5fq1wxz8 262 30 lead lead VB cord-283202-5fq1wxz8 262 31 to to IN cord-283202-5fq1wxz8 262 32 deterioration deterioration NN cord-283202-5fq1wxz8 262 33 or or CC cord-283202-5fq1wxz8 262 34 death death NN cord-283202-5fq1wxz8 262 35 in in IN cord-283202-5fq1wxz8 262 36 animals animal NNS cord-283202-5fq1wxz8 262 37 with with IN cord-283202-5fq1wxz8 262 38 severe severe JJ cord-283202-5fq1wxz8 262 39 raised raise VBN cord-283202-5fq1wxz8 262 40 intracranial intracranial JJ cord-283202-5fq1wxz8 262 41 pressure pressure NN cord-283202-5fq1wxz8 262 42 . . . cord-283202-5fq1wxz8 263 1 In in IN cord-283202-5fq1wxz8 263 2 humans human NNS cord-283202-5fq1wxz8 263 3 with with IN cord-283202-5fq1wxz8 263 4 hypertensive hypertensive JJ cord-283202-5fq1wxz8 263 5 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 263 6 , , , cord-283202-5fq1wxz8 263 7 MRI MRI NNP cord-283202-5fq1wxz8 263 8 of of IN cord-283202-5fq1wxz8 263 9 the the DT cord-283202-5fq1wxz8 263 10 402 402 CD cord-283202-5fq1wxz8 263 11 JFMS JFMS NNP cord-283202-5fq1wxz8 263 12 CLINICAL CLINICAL NNP cord-283202-5fq1wxz8 263 13 PRACTICE practice NN cord-283202-5fq1wxz8 263 14 brain brain NN cord-283202-5fq1wxz8 263 15 discloses disclose VBZ cord-283202-5fq1wxz8 263 16 hyperintensities hyperintensitie NNS cord-283202-5fq1wxz8 263 17 in in IN cord-283202-5fq1wxz8 263 18 the the DT cord-283202-5fq1wxz8 263 19 white white JJ cord-283202-5fq1wxz8 263 20 matter matter NN cord-283202-5fq1wxz8 263 21 of of IN cord-283202-5fq1wxz8 263 22 the the DT cord-283202-5fq1wxz8 263 23 parietal parietal JJ cord-283202-5fq1wxz8 263 24 and and CC cord-283202-5fq1wxz8 263 25 occipital occipital JJ cord-283202-5fq1wxz8 263 26 lobes lobe NNS cord-283202-5fq1wxz8 263 27 of of IN cord-283202-5fq1wxz8 263 28 the the DT cord-283202-5fq1wxz8 263 29 cerebrum cerebrum NN cord-283202-5fq1wxz8 263 30 on on IN cord-283202-5fq1wxz8 263 31 T2-weighted t2-weighte VBN cord-283202-5fq1wxz8 263 32 images image NNS cord-283202-5fq1wxz8 263 33 . . . cord-283202-5fq1wxz8 264 1 96 96 CD cord-283202-5fq1wxz8 264 2 Less less RBR cord-283202-5fq1wxz8 264 3 frequently frequently RB cord-283202-5fq1wxz8 264 4 , , , cord-283202-5fq1wxz8 264 5 similar similar JJ cord-283202-5fq1wxz8 264 6 findings finding NNS cord-283202-5fq1wxz8 264 7 may may MD cord-283202-5fq1wxz8 264 8 be be VB cord-283202-5fq1wxz8 264 9 observed observe VBN cord-283202-5fq1wxz8 264 10 in in IN cord-283202-5fq1wxz8 264 11 the the DT cord-283202-5fq1wxz8 264 12 brainstem brainstem NN cord-283202-5fq1wxz8 264 13 . . . cord-283202-5fq1wxz8 265 1 100 100 CD cord-283202-5fq1wxz8 265 2 Magnetic magnetic JJ cord-283202-5fq1wxz8 265 3 resonance resonance NN cord-283202-5fq1wxz8 265 4 imaging imaging NN cord-283202-5fq1wxz8 265 5 in in IN cord-283202-5fq1wxz8 265 6 hypertensive hypertensive JJ cord-283202-5fq1wxz8 265 7 cats cat NNS cord-283202-5fq1wxz8 265 8 has have VBZ cord-283202-5fq1wxz8 265 9 not not RB cord-283202-5fq1wxz8 265 10 been be VBN cord-283202-5fq1wxz8 265 11 studied study VBN cord-283202-5fq1wxz8 265 12 ; ; : cord-283202-5fq1wxz8 265 13 however however RB cord-283202-5fq1wxz8 265 14 , , , cord-283202-5fq1wxz8 265 15 given give VBN cord-283202-5fq1wxz8 265 16 the the DT cord-283202-5fq1wxz8 265 17 gross gross JJ cord-283202-5fq1wxz8 265 18 and and CC cord-283202-5fq1wxz8 265 19 microscopic microscopic JJ cord-283202-5fq1wxz8 265 20 changes change NNS cord-283202-5fq1wxz8 265 21 observed observe VBN cord-283202-5fq1wxz8 265 22 in in IN cord-283202-5fq1wxz8 265 23 affected affected JJ cord-283202-5fq1wxz8 265 24 cats cat NNS cord-283202-5fq1wxz8 265 25 , , , cord-283202-5fq1wxz8 265 26 similar similar JJ cord-283202-5fq1wxz8 265 27 findings finding NNS cord-283202-5fq1wxz8 265 28 would would MD cord-283202-5fq1wxz8 265 29 be be VB cord-283202-5fq1wxz8 265 30 expected expect VBN cord-283202-5fq1wxz8 265 31 . . . cord-283202-5fq1wxz8 266 1 Unfortunately unfortunately RB cord-283202-5fq1wxz8 266 2 , , , cord-283202-5fq1wxz8 266 3 control control NN cord-283202-5fq1wxz8 266 4 of of IN cord-283202-5fq1wxz8 266 5 hypertension hypertension NN cord-283202-5fq1wxz8 266 6 does do VBZ cord-283202-5fq1wxz8 266 7 not not RB cord-283202-5fq1wxz8 266 8 appear appear VB cord-283202-5fq1wxz8 266 9 to to TO cord-283202-5fq1wxz8 266 10 have have VB cord-283202-5fq1wxz8 266 11 a a DT cord-283202-5fq1wxz8 266 12 significant significant JJ cord-283202-5fq1wxz8 266 13 effect effect NN cord-283202-5fq1wxz8 266 14 on on IN cord-283202-5fq1wxz8 266 15 survival survival NN cord-283202-5fq1wxz8 266 16 time time NN cord-283202-5fq1wxz8 266 17 . . . cord-283202-5fq1wxz8 267 1 82 82 CD cord-283202-5fq1wxz8 267 2 , , , cord-283202-5fq1wxz8 267 3 83 83 CD cord-283202-5fq1wxz8 267 4 , , , cord-283202-5fq1wxz8 267 5 108 108 CD cord-283202-5fq1wxz8 267 6 , , , cord-283202-5fq1wxz8 267 7 109 109 CD cord-283202-5fq1wxz8 267 8 However however RB cord-283202-5fq1wxz8 267 9 , , , cord-283202-5fq1wxz8 267 10 amlodipine amlodipine NN cord-283202-5fq1wxz8 267 11 does do VBZ cord-283202-5fq1wxz8 267 12 seem seem VB cord-283202-5fq1wxz8 267 13 to to TO cord-283202-5fq1wxz8 267 14 reduce reduce VB cord-283202-5fq1wxz8 267 15 the the DT cord-283202-5fq1wxz8 267 16 degree degree NN cord-283202-5fq1wxz8 267 17 of of IN cord-283202-5fq1wxz8 267 18 proteinuria proteinuria NN cord-283202-5fq1wxz8 267 19 in in IN cord-283202-5fq1wxz8 267 20 cats cat NNS cord-283202-5fq1wxz8 267 21 with with IN cord-283202-5fq1wxz8 267 22 renal renal JJ cord-283202-5fq1wxz8 267 23 disease disease NN cord-283202-5fq1wxz8 267 24 , , , cord-283202-5fq1wxz8 267 25 and and CC cord-283202-5fq1wxz8 267 26 a a DT cord-283202-5fq1wxz8 267 27 reduction reduction NN cord-283202-5fq1wxz8 267 28 in in IN cord-283202-5fq1wxz8 267 29 proteinuria proteinuria NN cord-283202-5fq1wxz8 267 30 appears appear VBZ cord-283202-5fq1wxz8 267 31 to to TO cord-283202-5fq1wxz8 267 32 have have VB cord-283202-5fq1wxz8 267 33 a a DT cord-283202-5fq1wxz8 267 34 positive positive JJ cord-283202-5fq1wxz8 267 35 effect effect NN cord-283202-5fq1wxz8 267 36 on on IN cord-283202-5fq1wxz8 267 37 survival survival NN cord-283202-5fq1wxz8 267 38 time time NN cord-283202-5fq1wxz8 267 39 . . . cord-283202-5fq1wxz8 268 1 108 108 CD cord-283202-5fq1wxz8 268 2 , , , cord-283202-5fq1wxz8 268 3 109 109 CD cord-283202-5fq1wxz8 269 1 Unless unless IN cord-283202-5fq1wxz8 269 2 animals animal NNS cord-283202-5fq1wxz8 269 3 are be VBP cord-283202-5fq1wxz8 269 4 showing show VBG cord-283202-5fq1wxz8 269 5 evidence evidence NN cord-283202-5fq1wxz8 269 6 of of IN cord-283202-5fq1wxz8 269 7 target target NN cord-283202-5fq1wxz8 269 8 organ organ NN cord-283202-5fq1wxz8 269 9 damage damage NN cord-283202-5fq1wxz8 269 10 , , , cord-283202-5fq1wxz8 269 11 or or CC cord-283202-5fq1wxz8 269 12 are be VBP cord-283202-5fq1wxz8 269 13 at at IN cord-283202-5fq1wxz8 269 14 severe severe JJ cord-283202-5fq1wxz8 269 15 risk risk NN cord-283202-5fq1wxz8 269 16 of of IN cord-283202-5fq1wxz8 269 17 developing develop VBG cord-283202-5fq1wxz8 269 18 target target NN cord-283202-5fq1wxz8 269 19 organ organ NN cord-283202-5fq1wxz8 269 20 damage damage NN cord-283202-5fq1wxz8 269 21 ( ( -LRB- cord-283202-5fq1wxz8 269 22 see see VB cord-283202-5fq1wxz8 269 23 box box NN cord-283202-5fq1wxz8 269 24 on on IN cord-283202-5fq1wxz8 269 25 page page NN cord-283202-5fq1wxz8 269 26 401 401 CD cord-283202-5fq1wxz8 269 27 ) ) -RRB- cord-283202-5fq1wxz8 269 28 , , , cord-283202-5fq1wxz8 269 29 there there EX cord-283202-5fq1wxz8 269 30 is be VBZ cord-283202-5fq1wxz8 269 31 no no DT cord-283202-5fq1wxz8 269 32 requirement requirement NN cord-283202-5fq1wxz8 269 33 for for IN cord-283202-5fq1wxz8 269 34 immediate immediate JJ cord-283202-5fq1wxz8 269 35 therapeutic therapeutic JJ cord-283202-5fq1wxz8 269 36 intervention intervention NN cord-283202-5fq1wxz8 269 37 . . . cord-283202-5fq1wxz8 270 1 Instead instead RB cord-283202-5fq1wxz8 270 2 , , , cord-283202-5fq1wxz8 270 3 repeated repeat VBD cord-283202-5fq1wxz8 270 4 blood blood NN cord-283202-5fq1wxz8 270 5 measurements measurement NNS cord-283202-5fq1wxz8 270 6 over over IN cord-283202-5fq1wxz8 270 7 a a DT cord-283202-5fq1wxz8 270 8 period period NN cord-283202-5fq1wxz8 270 9 of of IN cord-283202-5fq1wxz8 270 10 time time NN cord-283202-5fq1wxz8 270 11 , , , cord-283202-5fq1wxz8 270 12 combined combine VBN cord-283202-5fq1wxz8 270 13 with with IN cord-283202-5fq1wxz8 270 14 identification identification NN cord-283202-5fq1wxz8 270 15 and and CC cord-283202-5fq1wxz8 270 16 treatment treatment NN cord-283202-5fq1wxz8 270 17 of of IN cord-283202-5fq1wxz8 270 18 any any DT cord-283202-5fq1wxz8 270 19 potential potential JJ cord-283202-5fq1wxz8 270 20 underlying underlie VBG cord-283202-5fq1wxz8 270 21 disease disease NN cord-283202-5fq1wxz8 270 22 process process NN cord-283202-5fq1wxz8 270 23 leading lead VBG cord-283202-5fq1wxz8 270 24 to to IN cord-283202-5fq1wxz8 270 25 hypertension hypertension NN cord-283202-5fq1wxz8 270 26 , , , cord-283202-5fq1wxz8 270 27 may may MD cord-283202-5fq1wxz8 270 28 be be VB cord-283202-5fq1wxz8 270 29 all all DT cord-283202-5fq1wxz8 270 30 that that WDT cord-283202-5fq1wxz8 270 31 is be VBZ cord-283202-5fq1wxz8 270 32 needed need VBN cord-283202-5fq1wxz8 270 33 to to TO cord-283202-5fq1wxz8 270 34 control control VB cord-283202-5fq1wxz8 270 35 blood blood NN cord-283202-5fq1wxz8 270 36 pressure pressure NN cord-283202-5fq1wxz8 270 37 . . . cord-283202-5fq1wxz8 271 1 In in IN cord-283202-5fq1wxz8 271 2 cats cat NNS cord-283202-5fq1wxz8 271 3 that that WDT cord-283202-5fq1wxz8 271 4 remain remain VBP cord-283202-5fq1wxz8 271 5 hypertensive hypertensive JJ cord-283202-5fq1wxz8 271 6 despite despite IN cord-283202-5fq1wxz8 271 7 control control NN cord-283202-5fq1wxz8 271 8 of of IN cord-283202-5fq1wxz8 271 9 an an DT cord-283202-5fq1wxz8 271 10 underlying underlie VBG cord-283202-5fq1wxz8 271 11 disease disease NN cord-283202-5fq1wxz8 271 12 process process NN cord-283202-5fq1wxz8 271 13 , , , cord-283202-5fq1wxz8 271 14 or or CC cord-283202-5fq1wxz8 271 15 those those DT cord-283202-5fq1wxz8 271 16 with with IN cord-283202-5fq1wxz8 271 17 idiopathic idiopathic JJ cord-283202-5fq1wxz8 271 18 hypertension hypertension NN cord-283202-5fq1wxz8 271 19 in in IN cord-283202-5fq1wxz8 271 20 the the DT cord-283202-5fq1wxz8 271 21 mild mild JJ cord-283202-5fq1wxz8 271 22 to to TO cord-283202-5fq1wxz8 271 23 moderate moderate JJ cord-283202-5fq1wxz8 271 24 risk risk NN cord-283202-5fq1wxz8 271 25 category category NN cord-283202-5fq1wxz8 271 26 for for IN cord-283202-5fq1wxz8 271 27 target target NN cord-283202-5fq1wxz8 271 28 organ organ NN cord-283202-5fq1wxz8 271 29 damage damage NN cord-283202-5fq1wxz8 271 30 , , , cord-283202-5fq1wxz8 271 31 the the DT cord-283202-5fq1wxz8 271 32 decision decision NN cord-283202-5fq1wxz8 271 33 to to TO cord-283202-5fq1wxz8 271 34 pursue pursue VB cord-283202-5fq1wxz8 271 35 hypertensive hypertensive JJ cord-283202-5fq1wxz8 271 36 therapy therapy NN cord-283202-5fq1wxz8 271 37 requires require VBZ cord-283202-5fq1wxz8 271 38 a a DT cord-283202-5fq1wxz8 271 39 dedicated dedicated JJ cord-283202-5fq1wxz8 271 40 owner owner NN cord-283202-5fq1wxz8 271 41 as as IN cord-283202-5fq1wxz8 271 42 treatment treatment NN cord-283202-5fq1wxz8 271 43 is be VBZ cord-283202-5fq1wxz8 271 44 generally generally RB cord-283202-5fq1wxz8 271 45 lifelong lifelong JJ cord-283202-5fq1wxz8 271 46 and and CC cord-283202-5fq1wxz8 271 47 involves involve VBZ cord-283202-5fq1wxz8 271 48 frequent frequent JJ cord-283202-5fq1wxz8 271 49 re re NNS cord-283202-5fq1wxz8 271 50 - - NNS cord-283202-5fq1wxz8 271 51 evaluations evaluation NNS cord-283202-5fq1wxz8 271 52 . . . cord-283202-5fq1wxz8 272 1 In in IN cord-283202-5fq1wxz8 272 2 animals animal NNS cord-283202-5fq1wxz8 272 3 displaying display VBG cord-283202-5fq1wxz8 272 4 signs sign NNS cord-283202-5fq1wxz8 272 5 consistent consistent JJ cord-283202-5fq1wxz8 272 6 with with IN cord-283202-5fq1wxz8 272 7 hypertensive hypertensive JJ cord-283202-5fq1wxz8 272 8 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 272 9 , , , cord-283202-5fq1wxz8 272 10 prompt prompt JJ cord-283202-5fq1wxz8 272 11 intervention intervention NN cord-283202-5fq1wxz8 272 12 should should MD cord-283202-5fq1wxz8 272 13 be be VB cord-283202-5fq1wxz8 272 14 pursued pursue VBN cord-283202-5fq1wxz8 272 15 . . . cord-283202-5fq1wxz8 273 1 The the DT cord-283202-5fq1wxz8 273 2 treatment treatment NN cord-283202-5fq1wxz8 273 3 of of IN cord-283202-5fq1wxz8 273 4 choice choice NN cord-283202-5fq1wxz8 273 5 for for IN cord-283202-5fq1wxz8 273 6 hypertension hypertension NN cord-283202-5fq1wxz8 273 7 in in IN cord-283202-5fq1wxz8 273 8 cats cat NNS cord-283202-5fq1wxz8 273 9 is be VBZ cord-283202-5fq1wxz8 273 10 amlodipine amlodipine NN cord-283202-5fq1wxz8 273 11 besylate besylate NNP cord-283202-5fq1wxz8 273 12 , , , cord-283202-5fq1wxz8 273 13 a a DT cord-283202-5fq1wxz8 273 14 calcium calcium NN cord-283202-5fq1wxz8 273 15 channel channel NN cord-283202-5fq1wxz8 273 16 blocker blocker NN cord-283202-5fq1wxz8 273 17 . . . cord-283202-5fq1wxz8 274 1 82,99,101 82,99,101 CD cord-283202-5fq1wxz8 274 2 - - SYM cord-283202-5fq1wxz8 274 3 103 103 CD cord-283202-5fq1wxz8 274 4 A a DT cord-283202-5fq1wxz8 274 5 dose dose NN cord-283202-5fq1wxz8 274 6 of of IN cord-283202-5fq1wxz8 274 7 0.625 0.625 CD cord-283202-5fq1wxz8 274 8 - - SYM cord-283202-5fq1wxz8 274 9 1.25 1.25 CD cord-283202-5fq1wxz8 274 10 mg mg NNP cord-283202-5fq1wxz8 274 11 / / SYM cord-283202-5fq1wxz8 274 12 cat cat NN cord-283202-5fq1wxz8 274 13 orally orally RB cord-283202-5fq1wxz8 274 14 once once RB cord-283202-5fq1wxz8 274 15 to to IN cord-283202-5fq1wxz8 274 16 twice twice RB cord-283202-5fq1wxz8 274 17 daily daily RB cord-283202-5fq1wxz8 274 18 reliably reliably RB cord-283202-5fq1wxz8 274 19 reduces reduce VBZ cord-283202-5fq1wxz8 274 20 blood blood NN cord-283202-5fq1wxz8 274 21 pressure pressure NN cord-283202-5fq1wxz8 274 22 with with IN cord-283202-5fq1wxz8 274 23 minimal minimal JJ cord-283202-5fq1wxz8 274 24 risk risk NN cord-283202-5fq1wxz8 274 25 of of IN cord-283202-5fq1wxz8 274 26 causing cause VBG cord-283202-5fq1wxz8 274 27 hypotension hypotension NN cord-283202-5fq1wxz8 274 28 . . . cord-283202-5fq1wxz8 275 1 82,101 82,101 CD cord-283202-5fq1wxz8 275 2 - - SYM cord-283202-5fq1wxz8 275 3 104 104 CD cord-283202-5fq1wxz8 276 1 Furthermore furthermore RB cord-283202-5fq1wxz8 276 2 , , , cord-283202-5fq1wxz8 276 3 treatment treatment NN cord-283202-5fq1wxz8 276 4 with with IN cord-283202-5fq1wxz8 276 5 amlodipine amlodipine NN cord-283202-5fq1wxz8 276 6 is be VBZ cord-283202-5fq1wxz8 276 7 not not RB cord-283202-5fq1wxz8 276 8 associated associate VBN cord-283202-5fq1wxz8 276 9 with with IN cord-283202-5fq1wxz8 276 10 increases increase NNS cord-283202-5fq1wxz8 276 11 in in IN cord-283202-5fq1wxz8 276 12 blood blood NN cord-283202-5fq1wxz8 276 13 urea urea NN cord-283202-5fq1wxz8 276 14 nitrogen nitrogen NN cord-283202-5fq1wxz8 276 15 and and CC cord-283202-5fq1wxz8 276 16 creatinine creatinine NN cord-283202-5fq1wxz8 276 17 in in IN cord-283202-5fq1wxz8 276 18 cats cat NNS cord-283202-5fq1wxz8 276 19 with with IN cord-283202-5fq1wxz8 276 20 chronic chronic JJ cord-283202-5fq1wxz8 276 21 renal renal JJ cord-283202-5fq1wxz8 276 22 failure failure NN cord-283202-5fq1wxz8 276 23 . . . cord-283202-5fq1wxz8 277 1 103 103 CD cord-283202-5fq1wxz8 277 2 , , , cord-283202-5fq1wxz8 277 3 104 104 CD cord-283202-5fq1wxz8 278 1 In in IN cord-283202-5fq1wxz8 278 2 cats cat NNS cord-283202-5fq1wxz8 278 3 in in IN cord-283202-5fq1wxz8 278 4 which which WDT cord-283202-5fq1wxz8 278 5 amlodipine amlodipine NN cord-283202-5fq1wxz8 278 6 is be VBZ cord-283202-5fq1wxz8 278 7 ineffective ineffective JJ cord-283202-5fq1wxz8 278 8 at at IN cord-283202-5fq1wxz8 278 9 controlling control VBG cord-283202-5fq1wxz8 278 10 hypertension hypertension NN cord-283202-5fq1wxz8 278 11 , , , cord-283202-5fq1wxz8 278 12 adjunctive adjunctive JJ cord-283202-5fq1wxz8 278 13 therapy therapy NN cord-283202-5fq1wxz8 278 14 with with IN cord-283202-5fq1wxz8 278 15 the the DT cord-283202-5fq1wxz8 278 16 β1 β1 NNP cord-283202-5fq1wxz8 278 17 selective selective JJ cord-283202-5fq1wxz8 278 18 β β NN cord-283202-5fq1wxz8 278 19 - - HYPH cord-283202-5fq1wxz8 278 20 blocker blocker NNP cord-283202-5fq1wxz8 278 21 , , , cord-283202-5fq1wxz8 278 22 atenolol atenolol NN cord-283202-5fq1wxz8 278 23 , , , cord-283202-5fq1wxz8 278 24 may may MD cord-283202-5fq1wxz8 278 25 be be VB cord-283202-5fq1wxz8 278 26 instituted institute VBN cord-283202-5fq1wxz8 278 27 at at IN cord-283202-5fq1wxz8 278 28 6.25 6.25 CD cord-283202-5fq1wxz8 278 29 - - SYM cord-283202-5fq1wxz8 278 30 12.5 12.5 CD cord-283202-5fq1wxz8 278 31 mg mg NNP cord-283202-5fq1wxz8 278 32 / / SYM cord-283202-5fq1wxz8 278 33 cat cat NN cord-283202-5fq1wxz8 278 34 PO po NN cord-283202-5fq1wxz8 278 35 q q NNP cord-283202-5fq1wxz8 278 36 12 12 CD cord-283202-5fq1wxz8 278 37 - - SYM cord-283202-5fq1wxz8 278 38 24 24 CD cord-283202-5fq1wxz8 278 39 h. h. NN cord-283202-5fq1wxz8 278 40 105 105 CD cord-283202-5fq1wxz8 279 1 Alternatively alternatively RB cord-283202-5fq1wxz8 279 2 , , , cord-283202-5fq1wxz8 279 3 the the DT cord-283202-5fq1wxz8 279 4 angiotensin angiotensin NN cord-283202-5fq1wxz8 279 5 - - HYPH cord-283202-5fq1wxz8 279 6 converting convert VBG cord-283202-5fq1wxz8 279 7 enzyme enzyme NN cord-283202-5fq1wxz8 279 8 inhibitor inhibitor NN cord-283202-5fq1wxz8 279 9 , , , cord-283202-5fq1wxz8 279 10 benazepril benazepril NNP cord-283202-5fq1wxz8 279 11 , , , cord-283202-5fq1wxz8 279 12 at at IN cord-283202-5fq1wxz8 279 13 0.25 0.25 CD cord-283202-5fq1wxz8 279 14 - - SYM cord-283202-5fq1wxz8 279 15 0.5 0.5 CD cord-283202-5fq1wxz8 279 16 mg mg NNP cord-283202-5fq1wxz8 279 17 / / SYM cord-283202-5fq1wxz8 279 18 kg kg NNP cord-283202-5fq1wxz8 279 19 PO po NN cord-283202-5fq1wxz8 279 20 q q NNP cord-283202-5fq1wxz8 279 21 12 12 CD cord-283202-5fq1wxz8 279 22 - - SYM cord-283202-5fq1wxz8 279 23 24 24 CD cord-283202-5fq1wxz8 279 24 h h NN cord-283202-5fq1wxz8 279 25 can can MD cord-283202-5fq1wxz8 279 26 be be VB cord-283202-5fq1wxz8 279 27 used use VBN cord-283202-5fq1wxz8 279 28 . . . cord-283202-5fq1wxz8 280 1 106 106 CD cord-283202-5fq1wxz8 281 1 However however RB cord-283202-5fq1wxz8 281 2 , , , cord-283202-5fq1wxz8 281 3 benazepril benazepril NNP cord-283202-5fq1wxz8 281 4 therapy therapy NNP cord-283202-5fq1wxz8 281 5 is be VBZ cord-283202-5fq1wxz8 281 6 associated associate VBN cord-283202-5fq1wxz8 281 7 with with IN cord-283202-5fq1wxz8 281 8 only only RB cord-283202-5fq1wxz8 281 9 a a DT cord-283202-5fq1wxz8 281 10 small small JJ cord-283202-5fq1wxz8 281 11 but but CC cord-283202-5fq1wxz8 281 12 significant significant JJ cord-283202-5fq1wxz8 281 13 reduction reduction NN cord-283202-5fq1wxz8 281 14 in in IN cord-283202-5fq1wxz8 281 15 blood blood NN cord-283202-5fq1wxz8 281 16 pressure pressure NN cord-283202-5fq1wxz8 281 17 in in IN cord-283202-5fq1wxz8 281 18 cats cat NNS cord-283202-5fq1wxz8 281 19 with with IN cord-283202-5fq1wxz8 281 20 chronic chronic JJ cord-283202-5fq1wxz8 281 21 renal renal JJ cord-283202-5fq1wxz8 281 22 failure failure NN cord-283202-5fq1wxz8 281 23 . . . cord-283202-5fq1wxz8 282 1 106 106 CD cord-283202-5fq1wxz8 283 1 In in IN cord-283202-5fq1wxz8 283 2 acute acute JJ cord-283202-5fq1wxz8 283 3 hypertension hypertension NN cord-283202-5fq1wxz8 283 4 , , , cord-283202-5fq1wxz8 283 5 subcutaneous subcutaneous JJ cord-283202-5fq1wxz8 283 6 hydralazine hydralazine NNP cord-283202-5fq1wxz8 283 7 ( ( -LRB- cord-283202-5fq1wxz8 283 8 1.0 1.0 CD cord-283202-5fq1wxz8 283 9 - - SYM cord-283202-5fq1wxz8 283 10 2.5 2.5 CD cord-283202-5fq1wxz8 283 11 mg mg NNP cord-283202-5fq1wxz8 283 12 / / SYM cord-283202-5fq1wxz8 283 13 cat cat NN cord-283202-5fq1wxz8 283 14 ) ) -RRB- cord-283202-5fq1wxz8 283 15 has have VBZ cord-283202-5fq1wxz8 283 16 been be VBN cord-283202-5fq1wxz8 283 17 effective effective JJ cord-283202-5fq1wxz8 283 18 at at IN cord-283202-5fq1wxz8 283 19 reducing reduce VBG cord-283202-5fq1wxz8 283 20 blood blood NN cord-283202-5fq1wxz8 283 21 pressure pressure NN cord-283202-5fq1wxz8 283 22 without without IN cord-283202-5fq1wxz8 283 23 significant significant JJ cord-283202-5fq1wxz8 283 24 risk risk NN cord-283202-5fq1wxz8 283 25 of of IN cord-283202-5fq1wxz8 283 26 hypotension hypotension NN cord-283202-5fq1wxz8 283 27 . . . cord-283202-5fq1wxz8 284 1 84 84 CD cord-283202-5fq1wxz8 285 1 While while IN cord-283202-5fq1wxz8 285 2 parenteral parenteral JJ cord-283202-5fq1wxz8 285 3 hypotensive hypotensive JJ cord-283202-5fq1wxz8 285 4 medications medication NNS cord-283202-5fq1wxz8 285 5 may may MD cord-283202-5fq1wxz8 285 6 be be VB cord-283202-5fq1wxz8 285 7 preferable preferable JJ cord-283202-5fq1wxz8 285 8 in in IN cord-283202-5fq1wxz8 285 9 the the DT cord-283202-5fq1wxz8 285 10 setting setting NN cord-283202-5fq1wxz8 285 11 of of IN cord-283202-5fq1wxz8 285 12 severe severe JJ cord-283202-5fq1wxz8 285 13 hypertensive hypertensive JJ cord-283202-5fq1wxz8 285 14 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 285 15 , , , cord-283202-5fq1wxz8 285 16 the the DT cord-283202-5fq1wxz8 285 17 use use NN cord-283202-5fq1wxz8 285 18 of of IN cord-283202-5fq1wxz8 285 19 such such JJ cord-283202-5fq1wxz8 285 20 medications medication NNS cord-283202-5fq1wxz8 285 21 requires require VBZ cord-283202-5fq1wxz8 285 22 continuous continuous JJ cord-283202-5fq1wxz8 285 23 , , , cord-283202-5fq1wxz8 285 24 direct direct JJ cord-283202-5fq1wxz8 285 25 arterial arterial JJ cord-283202-5fq1wxz8 285 26 blood blood NN cord-283202-5fq1wxz8 285 27 pressure pressure NN cord-283202-5fq1wxz8 285 28 measurement measurement NN cord-283202-5fq1wxz8 285 29 and and CC cord-283202-5fq1wxz8 285 30 is be VBZ cord-283202-5fq1wxz8 285 31 associated associate VBN cord-283202-5fq1wxz8 285 32 with with IN cord-283202-5fq1wxz8 285 33 a a DT cord-283202-5fq1wxz8 285 34 significant significant JJ cord-283202-5fq1wxz8 285 35 risk risk NN cord-283202-5fq1wxz8 285 36 of of IN cord-283202-5fq1wxz8 285 37 hypotension hypotension NN cord-283202-5fq1wxz8 285 38 . . . cord-283202-5fq1wxz8 286 1 In in IN cord-283202-5fq1wxz8 286 2 cats cat NNS cord-283202-5fq1wxz8 286 3 with with IN cord-283202-5fq1wxz8 286 4 severe severe JJ cord-283202-5fq1wxz8 286 5 neurological neurological JJ cord-283202-5fq1wxz8 286 6 dysfunction dysfunction NN cord-283202-5fq1wxz8 286 7 that that WDT cord-283202-5fq1wxz8 286 8 do do VBP cord-283202-5fq1wxz8 286 9 not not RB cord-283202-5fq1wxz8 286 10 respond respond VB cord-283202-5fq1wxz8 286 11 to to IN cord-283202-5fq1wxz8 286 12 a a DT cord-283202-5fq1wxz8 286 13 reduction reduction NN cord-283202-5fq1wxz8 286 14 in in IN cord-283202-5fq1wxz8 286 15 blood blood NN cord-283202-5fq1wxz8 286 16 pressure pressure NN cord-283202-5fq1wxz8 286 17 , , , cord-283202-5fq1wxz8 286 18 treatment treatment NN cord-283202-5fq1wxz8 286 19 for for IN cord-283202-5fq1wxz8 286 20 raised raise VBN cord-283202-5fq1wxz8 286 21 intracranial intracranial JJ cord-283202-5fq1wxz8 286 22 pressure pressure NN cord-283202-5fq1wxz8 286 23 due due IN cord-283202-5fq1wxz8 286 24 to to IN cord-283202-5fq1wxz8 286 25 brain brain NN cord-283202-5fq1wxz8 286 26 edema edema NN cord-283202-5fq1wxz8 286 27 may may MD cord-283202-5fq1wxz8 286 28 be be VB cord-283202-5fq1wxz8 286 29 warranted warrant VBN cord-283202-5fq1wxz8 286 30 . . . cord-283202-5fq1wxz8 287 1 This this DT cord-283202-5fq1wxz8 287 2 entails entail VBZ cord-283202-5fq1wxz8 287 3 diuretic diuretic JJ cord-283202-5fq1wxz8 287 4 therapy therapy NN cord-283202-5fq1wxz8 287 5 with with IN cord-283202-5fq1wxz8 287 6 mannitol mannitol NNP cord-283202-5fq1wxz8 287 7 ( ( -LRB- cord-283202-5fq1wxz8 287 8 0.5 0.5 CD cord-283202-5fq1wxz8 287 9 to to TO cord-283202-5fq1wxz8 287 10 2 2 CD cord-283202-5fq1wxz8 287 11 g g NN cord-283202-5fq1wxz8 287 12 / / SYM cord-283202-5fq1wxz8 287 13 kg kg NN cord-283202-5fq1wxz8 287 14 IV IV NNP cord-283202-5fq1wxz8 287 15 over over IN cord-283202-5fq1wxz8 287 16 10 10 CD cord-283202-5fq1wxz8 287 17 - - SYM cord-283202-5fq1wxz8 287 18 15 15 CD cord-283202-5fq1wxz8 287 19 mins min NNS cord-283202-5fq1wxz8 287 20 often often RB cord-283202-5fq1wxz8 287 21 combined combine VBN cord-283202-5fq1wxz8 287 22 with with IN cord-283202-5fq1wxz8 287 23 furosemide furosemide NN cord-283202-5fq1wxz8 287 24 0.7 0.7 CD cord-283202-5fq1wxz8 287 25 mg mg NNP cord-283202-5fq1wxz8 287 26 / / SYM cord-283202-5fq1wxz8 287 27 kg kg NNP cord-283202-5fq1wxz8 287 28 IV IV NNP cord-283202-5fq1wxz8 287 29 ) ) -RRB- cord-283202-5fq1wxz8 287 30 , , , cord-283202-5fq1wxz8 287 31 or or CC cord-283202-5fq1wxz8 287 32 other other JJ cord-283202-5fq1wxz8 287 33 hypertonic hypertonic JJ cord-283202-5fq1wxz8 287 34 agents agent NNS cord-283202-5fq1wxz8 287 35 . . . cord-283202-5fq1wxz8 288 1 107 107 CD cord-283202-5fq1wxz8 288 2 Note note VB cord-283202-5fq1wxz8 288 3 , , , cord-283202-5fq1wxz8 288 4 however however RB cord-283202-5fq1wxz8 288 5 , , , cord-283202-5fq1wxz8 288 6 that that DT cord-283202-5fq1wxz8 288 7 diuretic diuretic JJ cord-283202-5fq1wxz8 288 8 therapy therapy NN cord-283202-5fq1wxz8 288 9 should should MD cord-283202-5fq1wxz8 288 10 not not RB cord-283202-5fq1wxz8 288 11 be be VB cord-283202-5fq1wxz8 288 12 used use VBN cord-283202-5fq1wxz8 288 13 until until IN cord-283202-5fq1wxz8 288 14 blood blood NN cord-283202-5fq1wxz8 288 15 pressure pressure NN cord-283202-5fq1wxz8 288 16 has have VBZ cord-283202-5fq1wxz8 288 17 normalized normalize VBN cord-283202-5fq1wxz8 288 18 , , , cord-283202-5fq1wxz8 288 19 as as IN cord-283202-5fq1wxz8 288 20 these these DT cord-283202-5fq1wxz8 288 21 agents agent NNS cord-283202-5fq1wxz8 288 22 can can MD cord-283202-5fq1wxz8 288 23 transiently transiently RB cord-283202-5fq1wxz8 288 24 increase increase VB cord-283202-5fq1wxz8 288 25 blood blood NN cord-283202-5fq1wxz8 288 26 pressure pressure NN cord-283202-5fq1wxz8 288 27 . . . cord-283202-5fq1wxz8 289 1 107 107 CD cord-283202-5fq1wxz8 289 2 Tre Tre NNP cord-283202-5fq1wxz8 289 3 a a DT cord-283202-5fq1wxz8 289 4 t t NN cord-283202-5fq1wxz8 289 5 m m NN cord-283202-5fq1wxz8 289 6 e e NN cord-283202-5fq1wxz8 289 7 n n NN cord-283202-5fq1wxz8 289 8 t t NN cord-283202-5fq1wxz8 289 9 o o NN cord-283202-5fq1wxz8 290 1 f f NNP cord-283202-5fq1wxz8 290 2 h h NNP cord-283202-5fq1wxz8 290 3 y y NNP cord-283202-5fq1wxz8 290 4 p p NN cord-283202-5fq1wxz8 291 1 e e LS cord-283202-5fq1wxz8 292 1 r r NNP cord-283202-5fq1wxz8 292 2 t t NNP cord-283202-5fq1wxz8 293 1 e e LS cord-283202-5fq1wxz8 293 2 n n NN cord-283202-5fq1wxz8 293 3 s s NNP cord-283202-5fq1wxz8 294 1 i i PRP cord-283202-5fq1wxz8 294 2 o o VBP cord-283202-5fq1wxz8 294 3 n n NN cord-283202-5fq1wxz8 294 4 _SP cord-283202-5fq1wxz8 294 5 Hepatic hepatic JJ cord-283202-5fq1wxz8 294 6 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 294 7 is be VBZ cord-283202-5fq1wxz8 294 8 the the DT cord-283202-5fq1wxz8 294 9 clinical clinical JJ cord-283202-5fq1wxz8 294 10 syndrome syndrome NN cord-283202-5fq1wxz8 294 11 of of IN cord-283202-5fq1wxz8 294 12 abnormal abnormal JJ cord-283202-5fq1wxz8 294 13 neurological neurological JJ cord-283202-5fq1wxz8 294 14 function function NN cord-283202-5fq1wxz8 294 15 caused cause VBN cord-283202-5fq1wxz8 294 16 by by IN cord-283202-5fq1wxz8 294 17 portosystemic portosystemic JJ cord-283202-5fq1wxz8 294 18 shunting shunt VBG cord-283202-5fq1wxz8 294 19 , , , cord-283202-5fq1wxz8 294 20 with with IN cord-283202-5fq1wxz8 294 21 or or CC cord-283202-5fq1wxz8 294 22 without without IN cord-283202-5fq1wxz8 294 23 intrinsic intrinsic JJ cord-283202-5fq1wxz8 294 24 liver liver NN cord-283202-5fq1wxz8 294 25 disease disease NN cord-283202-5fq1wxz8 294 26 . . . cord-283202-5fq1wxz8 295 1 110 110 CD cord-283202-5fq1wxz8 296 1 As as IN cord-283202-5fq1wxz8 296 2 a a DT cord-283202-5fq1wxz8 296 3 result result NN cord-283202-5fq1wxz8 296 4 , , , cord-283202-5fq1wxz8 296 5 HE he PRP cord-283202-5fq1wxz8 296 6 can can MD cord-283202-5fq1wxz8 296 7 develop develop VB cord-283202-5fq1wxz8 296 8 in in IN cord-283202-5fq1wxz8 296 9 cats cat NNS cord-283202-5fq1wxz8 296 10 with with IN cord-283202-5fq1wxz8 296 11 acquired acquire VBN cord-283202-5fq1wxz8 296 12 or or CC cord-283202-5fq1wxz8 296 13 congenital congenital JJ cord-283202-5fq1wxz8 296 14 liver liver NN cord-283202-5fq1wxz8 296 15 disorders disorder NNS cord-283202-5fq1wxz8 296 16 . . . cord-283202-5fq1wxz8 297 1 By by IN cord-283202-5fq1wxz8 297 2 far far RB cord-283202-5fq1wxz8 297 3 the the DT cord-283202-5fq1wxz8 297 4 most most RBS cord-283202-5fq1wxz8 297 5 common common JJ cord-283202-5fq1wxz8 297 6 cause cause NN cord-283202-5fq1wxz8 297 7 of of IN cord-283202-5fq1wxz8 297 8 HE he PRP cord-283202-5fq1wxz8 297 9 in in IN cord-283202-5fq1wxz8 297 10 cats cat NNS cord-283202-5fq1wxz8 297 11 is be VBZ cord-283202-5fq1wxz8 297 12 portosystemic portosystemic JJ cord-283202-5fq1wxz8 297 13 shunting shunt VBG cord-283202-5fq1wxz8 297 14 of of IN cord-283202-5fq1wxz8 297 15 blood blood NN cord-283202-5fq1wxz8 297 16 secondary secondary JJ cord-283202-5fq1wxz8 297 17 to to IN cord-283202-5fq1wxz8 297 18 a a DT cord-283202-5fq1wxz8 297 19 congenital congenital JJ cord-283202-5fq1wxz8 297 20 vascular vascular JJ cord-283202-5fq1wxz8 297 21 anomaly anomaly NN cord-283202-5fq1wxz8 297 22 . . . cord-283202-5fq1wxz8 298 1 111 111 CD cord-283202-5fq1wxz8 299 1 Regardless regardless RB cord-283202-5fq1wxz8 299 2 of of IN cord-283202-5fq1wxz8 299 3 the the DT cord-283202-5fq1wxz8 299 4 cause cause NN cord-283202-5fq1wxz8 299 5 of of IN cord-283202-5fq1wxz8 299 6 the the DT cord-283202-5fq1wxz8 299 7 underlying underlying JJ cord-283202-5fq1wxz8 299 8 liver liver NN cord-283202-5fq1wxz8 299 9 disease disease NN cord-283202-5fq1wxz8 299 10 , , , cord-283202-5fq1wxz8 299 11 the the DT cord-283202-5fq1wxz8 299 12 clinical clinical JJ cord-283202-5fq1wxz8 299 13 signs sign NNS cord-283202-5fq1wxz8 299 14 of of IN cord-283202-5fq1wxz8 299 15 HE he PRP cord-283202-5fq1wxz8 299 16 are be VBP cord-283202-5fq1wxz8 299 17 similar similar JJ cord-283202-5fq1wxz8 299 18 and and CC cord-283202-5fq1wxz8 299 19 can can MD cord-283202-5fq1wxz8 299 20 be be VB cord-283202-5fq1wxz8 299 21 divided divide VBN cord-283202-5fq1wxz8 299 22 into into IN cord-283202-5fq1wxz8 299 23 systemic systemic JJ cord-283202-5fq1wxz8 299 24 and and CC cord-283202-5fq1wxz8 299 25 neurological neurological JJ cord-283202-5fq1wxz8 299 26 signs sign NNS cord-283202-5fq1wxz8 299 27 . . . cord-283202-5fq1wxz8 300 1 Affected affected JJ cord-283202-5fq1wxz8 300 2 cats cat NNS cord-283202-5fq1wxz8 300 3 often often RB cord-283202-5fq1wxz8 300 4 display display VBP cord-283202-5fq1wxz8 300 5 intermittent intermittent JJ cord-283202-5fq1wxz8 300 6 clinical clinical JJ cord-283202-5fq1wxz8 300 7 signs sign NNS cord-283202-5fq1wxz8 300 8 that that WDT cord-283202-5fq1wxz8 300 9 may may MD cord-283202-5fq1wxz8 300 10 be be VB cord-283202-5fq1wxz8 300 11 associated associate VBN cord-283202-5fq1wxz8 300 12 with with IN cord-283202-5fq1wxz8 300 13 eating eat VBG cord-283202-5fq1wxz8 300 14 . . . cord-283202-5fq1wxz8 301 1 112 112 CD cord-283202-5fq1wxz8 301 2 Cats cat NNS cord-283202-5fq1wxz8 301 3 with with IN cord-283202-5fq1wxz8 301 4 portosystemic portosystemic JJ cord-283202-5fq1wxz8 301 5 shunts shunt NNS cord-283202-5fq1wxz8 301 6 are be VBP cord-283202-5fq1wxz8 301 7 generally generally RB cord-283202-5fq1wxz8 301 8 small small JJ cord-283202-5fq1wxz8 301 9 in in IN cord-283202-5fq1wxz8 301 10 stature stature NN cord-283202-5fq1wxz8 301 11 , , , cord-283202-5fq1wxz8 301 12 fail fail VBP cord-283202-5fq1wxz8 301 13 to to TO cord-283202-5fq1wxz8 301 14 thrive thrive VB cord-283202-5fq1wxz8 301 15 and and CC cord-283202-5fq1wxz8 301 16 grow grow VB cord-283202-5fq1wxz8 301 17 , , , cord-283202-5fq1wxz8 301 18 and and CC cord-283202-5fq1wxz8 301 19 lose lose VB cord-283202-5fq1wxz8 301 20 weight weight NN cord-283202-5fq1wxz8 301 21 . . . cord-283202-5fq1wxz8 302 1 [ [ -LRB- cord-283202-5fq1wxz8 302 2 112 112 CD cord-283202-5fq1wxz8 302 3 ] ] -RRB- cord-283202-5fq1wxz8 302 4 [ [ -LRB- cord-283202-5fq1wxz8 302 5 113 113 CD cord-283202-5fq1wxz8 302 6 ] ] -RRB- cord-283202-5fq1wxz8 302 7 [ [ -LRB- cord-283202-5fq1wxz8 302 8 114 114 CD cord-283202-5fq1wxz8 302 9 ] ] -RRB- cord-283202-5fq1wxz8 303 1 [ [ -LRB- cord-283202-5fq1wxz8 303 2 115 115 CD cord-283202-5fq1wxz8 303 3 ] ] -RRB- cord-283202-5fq1wxz8 303 4 Pytalism Pytalism NNP cord-283202-5fq1wxz8 303 5 is be VBZ cord-283202-5fq1wxz8 303 6 a a DT cord-283202-5fq1wxz8 303 7 common common JJ cord-283202-5fq1wxz8 303 8 clinical clinical JJ cord-283202-5fq1wxz8 303 9 sign sign NN cord-283202-5fq1wxz8 303 10 , , , cord-283202-5fq1wxz8 303 11 occurring occur VBG cord-283202-5fq1wxz8 303 12 in in IN cord-283202-5fq1wxz8 303 13 approximately approximately RB cord-283202-5fq1wxz8 303 14 75 75 CD cord-283202-5fq1wxz8 303 15 % % NN cord-283202-5fq1wxz8 303 16 of of IN cord-283202-5fq1wxz8 303 17 cats cat NNS cord-283202-5fq1wxz8 303 18 . . . cord-283202-5fq1wxz8 304 1 112 112 CD cord-283202-5fq1wxz8 304 2 , , , cord-283202-5fq1wxz8 304 3 [ [ -LRB- cord-283202-5fq1wxz8 304 4 116 116 CD cord-283202-5fq1wxz8 304 5 ] ] -RRB- cord-283202-5fq1wxz8 304 6 [ [ -LRB- cord-283202-5fq1wxz8 304 7 117 117 CD cord-283202-5fq1wxz8 304 8 ] ] -RRB- cord-283202-5fq1wxz8 304 9 [ [ -LRB- cord-283202-5fq1wxz8 304 10 118 118 CD cord-283202-5fq1wxz8 304 11 ] ] -RRB- cord-283202-5fq1wxz8 304 12 [ [ -LRB- cord-283202-5fq1wxz8 304 13 119 119 CD cord-283202-5fq1wxz8 304 14 ] ] -RRB- cord-283202-5fq1wxz8 305 1 [ [ -LRB- cord-283202-5fq1wxz8 305 2 120 120 CD cord-283202-5fq1wxz8 305 3 ] ] -RRB- cord-283202-5fq1wxz8 306 1 Other other JJ cord-283202-5fq1wxz8 306 2 , , , cord-283202-5fq1wxz8 306 3 less less RBR cord-283202-5fq1wxz8 306 4 common common JJ cord-283202-5fq1wxz8 306 5 clinical clinical JJ cord-283202-5fq1wxz8 306 6 signs sign NNS cord-283202-5fq1wxz8 306 7 include include VBP cord-283202-5fq1wxz8 306 8 gastrointestinal gastrointestinal JJ cord-283202-5fq1wxz8 306 9 signs sign NNS cord-283202-5fq1wxz8 306 10 such such JJ cord-283202-5fq1wxz8 306 11 as as IN cord-283202-5fq1wxz8 306 12 decreased decrease VBN cord-283202-5fq1wxz8 306 13 appetite appetite NN cord-283202-5fq1wxz8 306 14 , , , cord-283202-5fq1wxz8 306 15 anorexia anorexia NN cord-283202-5fq1wxz8 306 16 , , , cord-283202-5fq1wxz8 306 17 pica pica NN cord-283202-5fq1wxz8 306 18 , , , cord-283202-5fq1wxz8 306 19 vomiting vomiting NN cord-283202-5fq1wxz8 306 20 , , , cord-283202-5fq1wxz8 306 21 diarrhea diarrhea NN cord-283202-5fq1wxz8 306 22 or or CC cord-283202-5fq1wxz8 306 23 constipation constipation NN cord-283202-5fq1wxz8 306 24 . . . cord-283202-5fq1wxz8 307 1 112 112 CD cord-283202-5fq1wxz8 307 2 , , , cord-283202-5fq1wxz8 307 3 113 113 CD cord-283202-5fq1wxz8 307 4 , , , cord-283202-5fq1wxz8 307 5 117 117 CD cord-283202-5fq1wxz8 307 6 Cats cat NNS cord-283202-5fq1wxz8 307 7 may may MD cord-283202-5fq1wxz8 307 8 demonstrate demonstrate VB cord-283202-5fq1wxz8 307 9 polydipsia polydipsia NN cord-283202-5fq1wxz8 307 10 , , , cord-283202-5fq1wxz8 307 11 and and CC cord-283202-5fq1wxz8 307 12 polyuria polyuria NN cord-283202-5fq1wxz8 307 13 , , , cord-283202-5fq1wxz8 307 14 pollakiuria pollakiuria NNP cord-283202-5fq1wxz8 307 15 and and CC cord-283202-5fq1wxz8 307 16 stranguria stranguria NNP cord-283202-5fq1wxz8 307 17 may may MD cord-283202-5fq1wxz8 307 18 occur occur VB cord-283202-5fq1wxz8 307 19 as as IN cord-283202-5fq1wxz8 307 20 a a DT cord-283202-5fq1wxz8 307 21 consequence consequence NN cord-283202-5fq1wxz8 307 22 of of IN cord-283202-5fq1wxz8 307 23 cystic cystic JJ cord-283202-5fq1wxz8 307 24 calculi calculus NNS cord-283202-5fq1wxz8 307 25 . . . cord-283202-5fq1wxz8 308 1 112 112 CD cord-283202-5fq1wxz8 308 2 , , , cord-283202-5fq1wxz8 308 3 113 113 CD cord-283202-5fq1wxz8 308 4 , , , cord-283202-5fq1wxz8 308 5 117 117 CD cord-283202-5fq1wxz8 308 6 Affected affected JJ cord-283202-5fq1wxz8 308 7 cats cat NNS cord-283202-5fq1wxz8 308 8 may may MD cord-283202-5fq1wxz8 308 9 have have VB cord-283202-5fq1wxz8 308 10 copper copper NN cord-283202-5fq1wxz8 308 11 - - HYPH cord-283202-5fq1wxz8 308 12 coloured coloured JJ cord-283202-5fq1wxz8 308 13 irises iris NNS cord-283202-5fq1wxz8 308 14 . . . cord-283202-5fq1wxz8 309 1 121 121 CD cord-283202-5fq1wxz8 310 1 Although although IN cord-283202-5fq1wxz8 310 2 a a DT cord-283202-5fq1wxz8 310 3 complete complete JJ cord-283202-5fq1wxz8 310 4 understanding understanding NN cord-283202-5fq1wxz8 310 5 of of IN cord-283202-5fq1wxz8 310 6 the the DT cord-283202-5fq1wxz8 310 7 mechanisms mechanism NNS cord-283202-5fq1wxz8 310 8 underlying underlie VBG cord-283202-5fq1wxz8 310 9 HE he PRP cord-283202-5fq1wxz8 310 10 remains remain VBZ cord-283202-5fq1wxz8 310 11 elusive elusive JJ cord-283202-5fq1wxz8 310 12 , , , cord-283202-5fq1wxz8 310 13 it -PRON- PRP cord-283202-5fq1wxz8 310 14 is be VBZ cord-283202-5fq1wxz8 310 15 clear clear JJ cord-283202-5fq1wxz8 310 16 that that IN cord-283202-5fq1wxz8 310 17 the the DT cord-283202-5fq1wxz8 310 18 pathophysiology pathophysiology NN cord-283202-5fq1wxz8 310 19 involved involve VBN cord-283202-5fq1wxz8 310 20 is be VBZ cord-283202-5fq1wxz8 310 21 multifactorial multifactorial JJ cord-283202-5fq1wxz8 310 22 . . . cord-283202-5fq1wxz8 311 1 Despite despite IN cord-283202-5fq1wxz8 311 2 numerous numerous JJ cord-283202-5fq1wxz8 311 3 potential potential JJ cord-283202-5fq1wxz8 311 4 factors factor NNS cord-283202-5fq1wxz8 311 5 , , , cord-283202-5fq1wxz8 311 6 ammonia ammonia NN cord-283202-5fq1wxz8 311 7 remains remain VBZ cord-283202-5fq1wxz8 311 8 key key JJ cord-283202-5fq1wxz8 311 9 in in IN cord-283202-5fq1wxz8 311 10 the the DT cord-283202-5fq1wxz8 311 11 development development NN cord-283202-5fq1wxz8 311 12 of of IN cord-283202-5fq1wxz8 311 13 HE HE NNP cord-283202-5fq1wxz8 311 14 . . . cord-283202-5fq1wxz8 312 1 124 124 CD cord-283202-5fq1wxz8 313 1 Ammonia ammonia NN cord-283202-5fq1wxz8 313 2 is be VBZ cord-283202-5fq1wxz8 313 3 produced produce VBN cord-283202-5fq1wxz8 313 4 by by IN cord-283202-5fq1wxz8 313 5 bacteria bacteria NNS cord-283202-5fq1wxz8 313 6 in in IN cord-283202-5fq1wxz8 313 7 the the DT cord-283202-5fq1wxz8 313 8 gastrointestinal gastrointestinal JJ cord-283202-5fq1wxz8 313 9 tract tract NN cord-283202-5fq1wxz8 313 10 , , , cord-283202-5fq1wxz8 313 11 primarily primarily RB cord-283202-5fq1wxz8 313 12 the the DT cord-283202-5fq1wxz8 313 13 colon colon NN cord-283202-5fq1wxz8 313 14 , , , cord-283202-5fq1wxz8 313 15 as as IN cord-283202-5fq1wxz8 313 16 a a DT cord-283202-5fq1wxz8 313 17 consequence consequence NN cord-283202-5fq1wxz8 313 18 of of IN cord-283202-5fq1wxz8 313 19 protein protein NN cord-283202-5fq1wxz8 313 20 metabolism metabolism NN cord-283202-5fq1wxz8 313 21 . . . cord-283202-5fq1wxz8 314 1 125 125 CD cord-283202-5fq1wxz8 315 1 It -PRON- PRP cord-283202-5fq1wxz8 315 2 is be VBZ cord-283202-5fq1wxz8 315 3 also also RB cord-283202-5fq1wxz8 315 4 produced produce VBN cord-283202-5fq1wxz8 315 5 by by IN cord-283202-5fq1wxz8 315 6 the the DT cord-283202-5fq1wxz8 315 7 gastrointestinal gastrointestinal JJ cord-283202-5fq1wxz8 315 8 cells cell NNS cord-283202-5fq1wxz8 315 9 as as IN cord-283202-5fq1wxz8 315 10 a a DT cord-283202-5fq1wxz8 315 11 result result NN cord-283202-5fq1wxz8 315 12 of of IN cord-283202-5fq1wxz8 315 13 metabolism metabolism NN cord-283202-5fq1wxz8 315 14 of of IN cord-283202-5fq1wxz8 315 15 glutamine glutamine NN cord-283202-5fq1wxz8 315 16 , , , cord-283202-5fq1wxz8 315 17 the the DT cord-283202-5fq1wxz8 315 18 main main JJ cord-283202-5fq1wxz8 315 19 cellular cellular JJ cord-283202-5fq1wxz8 315 20 energy energy NN cord-283202-5fq1wxz8 315 21 source source NN cord-283202-5fq1wxz8 315 22 for for IN cord-283202-5fq1wxz8 315 23 the the DT cord-283202-5fq1wxz8 315 24 epithelium epithelium NN cord-283202-5fq1wxz8 315 25 . . . cord-283202-5fq1wxz8 316 1 126 126 CD cord-283202-5fq1wxz8 317 1 A a DT cord-283202-5fq1wxz8 317 2 further further JJ cord-283202-5fq1wxz8 317 3 source source NN cord-283202-5fq1wxz8 317 4 of of IN cord-283202-5fq1wxz8 317 5 ammonia ammonia NN cord-283202-5fq1wxz8 317 6 is be VBZ cord-283202-5fq1wxz8 317 7 the the DT cord-283202-5fq1wxz8 317 8 kidneys kidney NNS cord-283202-5fq1wxz8 317 9 , , , cord-283202-5fq1wxz8 317 10 during during IN cord-283202-5fq1wxz8 317 11 states state NNS cord-283202-5fq1wxz8 317 12 of of IN cord-283202-5fq1wxz8 317 13 hypokalemia hypokalemia NN cord-283202-5fq1wxz8 317 14 or or CC cord-283202-5fq1wxz8 317 15 alkalosis alkalosis NN cord-283202-5fq1wxz8 317 16 . . . cord-283202-5fq1wxz8 318 1 126 126 CD cord-283202-5fq1wxz8 319 1 Normally normally RB cord-283202-5fq1wxz8 319 2 , , , cord-283202-5fq1wxz8 319 3 the the DT cord-283202-5fq1wxz8 319 4 liver liver NN cord-283202-5fq1wxz8 319 5 efficiently efficiently RB cord-283202-5fq1wxz8 319 6 removes remove VBZ cord-283202-5fq1wxz8 319 7 ammonia ammonia NN cord-283202-5fq1wxz8 319 8 from from IN cord-283202-5fq1wxz8 319 9 the the DT cord-283202-5fq1wxz8 319 10 portal portal JJ cord-283202-5fq1wxz8 319 11 vasculature vasculature NN cord-283202-5fq1wxz8 319 12 , , , cord-283202-5fq1wxz8 319 13 ultimately ultimately RB cord-283202-5fq1wxz8 319 14 converting convert VBG cord-283202-5fq1wxz8 319 15 it -PRON- PRP cord-283202-5fq1wxz8 319 16 to to IN cord-283202-5fq1wxz8 319 17 urea urea VB cord-283202-5fq1wxz8 319 18 . . . cord-283202-5fq1wxz8 320 1 In in IN cord-283202-5fq1wxz8 320 2 animals animal NNS cord-283202-5fq1wxz8 320 3 with with IN cord-283202-5fq1wxz8 320 4 hepatic hepatic JJ cord-283202-5fq1wxz8 320 5 failure failure NN cord-283202-5fq1wxz8 320 6 or or CC cord-283202-5fq1wxz8 320 7 portosystemic portosystemic JJ cord-283202-5fq1wxz8 320 8 shunts shunt NNS cord-283202-5fq1wxz8 320 9 , , , cord-283202-5fq1wxz8 320 10 hyperammonemia hyperammonemia NNP cord-283202-5fq1wxz8 320 11 may may MD cord-283202-5fq1wxz8 320 12 develop develop VB cord-283202-5fq1wxz8 320 13 . . . cord-283202-5fq1wxz8 321 1 However however RB cord-283202-5fq1wxz8 321 2 , , , cord-283202-5fq1wxz8 321 3 the the DT cord-283202-5fq1wxz8 321 4 severity severity NN cord-283202-5fq1wxz8 321 5 of of IN cord-283202-5fq1wxz8 321 6 the the DT cord-283202-5fq1wxz8 321 7 neurological neurological JJ cord-283202-5fq1wxz8 321 8 signs sign NNS cord-283202-5fq1wxz8 321 9 does do VBZ cord-283202-5fq1wxz8 321 10 not not RB cord-283202-5fq1wxz8 321 11 always always RB cord-283202-5fq1wxz8 321 12 correlate correlate VB cord-283202-5fq1wxz8 321 13 with with IN cord-283202-5fq1wxz8 321 14 the the DT cord-283202-5fq1wxz8 321 15 degree degree NN cord-283202-5fq1wxz8 321 16 of of IN cord-283202-5fq1wxz8 321 17 hyperammonemia hyperammonemia NNP cord-283202-5fq1wxz8 321 18 . . . cord-283202-5fq1wxz8 322 1 127 127 CD cord-283202-5fq1wxz8 323 1 In in IN cord-283202-5fq1wxz8 323 2 fact fact NN cord-283202-5fq1wxz8 323 3 , , , cord-283202-5fq1wxz8 323 4 blood blood NN cord-283202-5fq1wxz8 323 5 ammonia ammonia NN cord-283202-5fq1wxz8 323 6 levels level NNS cord-283202-5fq1wxz8 323 7 may may MD cord-283202-5fq1wxz8 323 8 be be VB cord-283202-5fq1wxz8 323 9 normal normal JJ cord-283202-5fq1wxz8 323 10 in in IN cord-283202-5fq1wxz8 323 11 cats cat NNS cord-283202-5fq1wxz8 323 12 with with IN cord-283202-5fq1wxz8 323 13 HE he PRP cord-283202-5fq1wxz8 323 14 . . . cord-283202-5fq1wxz8 324 1 127 127 CD cord-283202-5fq1wxz8 325 1 This this DT cord-283202-5fq1wxz8 325 2 relates relate VBZ cord-283202-5fq1wxz8 325 3 to to IN cord-283202-5fq1wxz8 325 4 a a DT cord-283202-5fq1wxz8 325 5 greater great JJR cord-283202-5fq1wxz8 325 6 rate rate NN cord-283202-5fq1wxz8 325 7 of of IN cord-283202-5fq1wxz8 325 8 uptake uptake NN cord-283202-5fq1wxz8 325 9 of of IN cord-283202-5fq1wxz8 325 10 ammonia ammonia NN cord-283202-5fq1wxz8 325 11 in in IN cord-283202-5fq1wxz8 325 12 the the DT cord-283202-5fq1wxz8 325 13 CNS CNS NNP cord-283202-5fq1wxz8 325 14 in in IN cord-283202-5fq1wxz8 325 15 HE HE NNP cord-283202-5fq1wxz8 325 16 , , , cord-283202-5fq1wxz8 325 17 leading lead VBG cord-283202-5fq1wxz8 325 18 potentially potentially RB cord-283202-5fq1wxz8 325 19 to to IN cord-283202-5fq1wxz8 325 20 a a DT cord-283202-5fq1wxz8 325 21 high high JJ cord-283202-5fq1wxz8 325 22 CNS CNS NNP cord-283202-5fq1wxz8 325 23 ammonia ammonia NN cord-283202-5fq1wxz8 325 24 level level NN cord-283202-5fq1wxz8 325 25 in in IN cord-283202-5fq1wxz8 325 26 the the DT cord-283202-5fq1wxz8 325 27 face face NN cord-283202-5fq1wxz8 325 28 of of IN cord-283202-5fq1wxz8 325 29 a a DT cord-283202-5fq1wxz8 325 30 normal normal JJ cord-283202-5fq1wxz8 325 31 blood blood NN cord-283202-5fq1wxz8 325 32 ammonia ammonia NN cord-283202-5fq1wxz8 325 33 level level NN cord-283202-5fq1wxz8 325 34 . . . cord-283202-5fq1wxz8 326 1 128 128 CD cord-283202-5fq1wxz8 327 1 Although although IN cord-283202-5fq1wxz8 327 2 HE he PRP cord-283202-5fq1wxz8 327 3 is be VBZ cord-283202-5fq1wxz8 327 4 a a DT cord-283202-5fq1wxz8 327 5 syndrome syndrome NN cord-283202-5fq1wxz8 327 6 of of IN cord-283202-5fq1wxz8 327 7 neuronal neuronal JJ cord-283202-5fq1wxz8 327 8 dysfunction dysfunction NN cord-283202-5fq1wxz8 327 9 , , , cord-283202-5fq1wxz8 327 10 the the DT cord-283202-5fq1wxz8 327 11 neuropathological neuropathological JJ cord-283202-5fq1wxz8 327 12 consequences consequence NNS cord-283202-5fq1wxz8 327 13 of of IN cord-283202-5fq1wxz8 327 14 increased increase VBN cord-283202-5fq1wxz8 327 15 CNS CNS NNP cord-283202-5fq1wxz8 327 16 ammonia ammonia NN cord-283202-5fq1wxz8 327 17 are be VBP cord-283202-5fq1wxz8 327 18 played play VBN cord-283202-5fq1wxz8 327 19 out out RP cord-283202-5fq1wxz8 327 20 in in IN cord-283202-5fq1wxz8 327 21 the the DT cord-283202-5fq1wxz8 327 22 astrocyte astrocyte NN cord-283202-5fq1wxz8 327 23 . . . cord-283202-5fq1wxz8 328 1 129 129 CD cord-283202-5fq1wxz8 329 1 Normally normally RB cord-283202-5fq1wxz8 329 2 , , , cord-283202-5fq1wxz8 329 3 CNS CNS NNP cord-283202-5fq1wxz8 329 4 ammonia ammonia NN cord-283202-5fq1wxz8 329 5 undergoes undergo VBZ cord-283202-5fq1wxz8 329 6 energy energy NN cord-283202-5fq1wxz8 329 7 - - HYPH cord-283202-5fq1wxz8 329 8 dependent dependent JJ cord-283202-5fq1wxz8 329 9 metabolism metabolism NN cord-283202-5fq1wxz8 329 10 to to IN cord-283202-5fq1wxz8 329 11 glutamine glutamine NN cord-283202-5fq1wxz8 329 12 by by IN cord-283202-5fq1wxz8 329 13 the the DT cord-283202-5fq1wxz8 329 14 astrocytes astrocyte NNS cord-283202-5fq1wxz8 329 15 . . . cord-283202-5fq1wxz8 330 1 130 130 CD cord-283202-5fq1wxz8 330 2 With with IN cord-283202-5fq1wxz8 330 3 increased increase VBN cord-283202-5fq1wxz8 330 4 CNS CNS NNP cord-283202-5fq1wxz8 330 5 ammonia ammonia NN cord-283202-5fq1wxz8 330 6 , , , cord-283202-5fq1wxz8 330 7 astrocytes astrocyte NNS cord-283202-5fq1wxz8 330 8 become become VBN cord-283202-5fq1wxz8 330 9 overwhelmed overwhelmed JJ cord-283202-5fq1wxz8 330 10 , , , cord-283202-5fq1wxz8 330 11 leading lead VBG cord-283202-5fq1wxz8 330 12 to to IN cord-283202-5fq1wxz8 330 13 energy energy NN cord-283202-5fq1wxz8 330 14 depletion depletion NN cord-283202-5fq1wxz8 330 15 . . . cord-283202-5fq1wxz8 331 1 110 110 CD cord-283202-5fq1wxz8 331 2 Additionally additionally RB cord-283202-5fq1wxz8 331 3 , , , cord-283202-5fq1wxz8 331 4 the the DT cord-283202-5fq1wxz8 331 5 increased increase VBN cord-283202-5fq1wxz8 331 6 concentration concentration NN cord-283202-5fq1wxz8 331 7 of of IN cord-283202-5fq1wxz8 331 8 glutamine glutamine NN cord-283202-5fq1wxz8 331 9 in in IN cord-283202-5fq1wxz8 331 10 astrocytes astrocyte NNS cord-283202-5fq1wxz8 331 11 may may MD cord-283202-5fq1wxz8 331 12 act act VB cord-283202-5fq1wxz8 331 13 as as IN cord-283202-5fq1wxz8 331 14 an an DT cord-283202-5fq1wxz8 331 15 osmotic osmotic JJ cord-283202-5fq1wxz8 331 16 stress stress NN cord-283202-5fq1wxz8 331 17 , , , cord-283202-5fq1wxz8 331 18 leading lead VBG cord-283202-5fq1wxz8 331 19 to to IN cord-283202-5fq1wxz8 331 20 cell cell NN cord-283202-5fq1wxz8 331 21 swelling swelling NN cord-283202-5fq1wxz8 331 22 . . . cord-283202-5fq1wxz8 332 1 110 110 CD cord-283202-5fq1wxz8 332 2 Increased increase VBN cord-283202-5fq1wxz8 332 3 numbers number NNS cord-283202-5fq1wxz8 332 4 of of IN cord-283202-5fq1wxz8 332 5 swollen swollen JJ cord-283202-5fq1wxz8 332 6 astrocytes astrocyte NNS cord-283202-5fq1wxz8 332 7 -referred -referre VBN cord-283202-5fq1wxz8 333 1 to to IN cord-283202-5fq1wxz8 333 2 as as IN cord-283202-5fq1wxz8 333 3 Alzeheimer Alzeheimer NNP cord-283202-5fq1wxz8 333 4 type type NN cord-283202-5fq1wxz8 333 5 II II NNP cord-283202-5fq1wxz8 333 6 astrocytes astrocyte NNS cord-283202-5fq1wxz8 333 7 -is -is . cord-283202-5fq1wxz8 334 1 the the DT cord-283202-5fq1wxz8 334 2 only only JJ cord-283202-5fq1wxz8 334 3 structural structural JJ cord-283202-5fq1wxz8 334 4 change change NN cord-283202-5fq1wxz8 334 5 observed observe VBN cord-283202-5fq1wxz8 334 6 microscopically microscopically RB cord-283202-5fq1wxz8 334 7 in in IN cord-283202-5fq1wxz8 334 8 the the DT cord-283202-5fq1wxz8 334 9 brain brain NN cord-283202-5fq1wxz8 334 10 in in IN cord-283202-5fq1wxz8 334 11 HE HE NNP cord-283202-5fq1wxz8 334 12 . . . cord-283202-5fq1wxz8 335 1 131 131 CD cord-283202-5fq1wxz8 336 1 As as IN cord-283202-5fq1wxz8 336 2 a a DT cord-283202-5fq1wxz8 336 3 consequence consequence NN cord-283202-5fq1wxz8 336 4 of of IN cord-283202-5fq1wxz8 336 5 cellular cellular JJ cord-283202-5fq1wxz8 336 6 edema edema NN cord-283202-5fq1wxz8 336 7 , , , cord-283202-5fq1wxz8 336 8 neurotransmitter neurotransmitter NN cord-283202-5fq1wxz8 336 9 processing processing NN cord-283202-5fq1wxz8 336 10 in in IN cord-283202-5fq1wxz8 336 11 the the DT cord-283202-5fq1wxz8 336 12 astrocytes astrocyte NNS cord-283202-5fq1wxz8 336 13 is be VBZ cord-283202-5fq1wxz8 336 14 affected affect VBN cord-283202-5fq1wxz8 336 15 , , , cord-283202-5fq1wxz8 336 16 resulting result VBG cord-283202-5fq1wxz8 336 17 in in IN cord-283202-5fq1wxz8 336 18 upregulation upregulation NN cord-283202-5fq1wxz8 336 19 of of IN cord-283202-5fq1wxz8 336 20 neuronal neuronal JJ cord-283202-5fq1wxz8 336 21 benzodiazepine benzodiazepine NN cord-283202-5fq1wxz8 336 22 receptors receptor NNS cord-283202-5fq1wxz8 336 23 and and CC cord-283202-5fq1wxz8 336 24 the the DT cord-283202-5fq1wxz8 336 25 production production NN cord-283202-5fq1wxz8 336 26 of of IN cord-283202-5fq1wxz8 336 27 neurosteroids neurosteroid NNS cord-283202-5fq1wxz8 336 28 which which WDT cord-283202-5fq1wxz8 336 29 increase increase VBP cord-283202-5fq1wxz8 336 30 γ γ NN cord-283202-5fq1wxz8 336 31 - - HYPH cord-283202-5fq1wxz8 336 32 aminobutyric aminobutyric NN cord-283202-5fq1wxz8 336 33 acid acid NN cord-283202-5fq1wxz8 336 34 ( ( -LRB- cord-283202-5fq1wxz8 336 35 GABA GABA NNP cord-283202-5fq1wxz8 336 36 ) ) -RRB- cord-283202-5fq1wxz8 336 37 neurotransmission neurotransmission NN cord-283202-5fq1wxz8 336 38 and and CC cord-283202-5fq1wxz8 336 39 thereby thereby RB cord-283202-5fq1wxz8 336 40 ultimately ultimately RB cord-283202-5fq1wxz8 336 41 affect affect VBP cord-283202-5fq1wxz8 336 42 neuronal neuronal JJ cord-283202-5fq1wxz8 336 43 function function NN cord-283202-5fq1wxz8 336 44 . . . cord-283202-5fq1wxz8 337 1 110 110 CD cord-283202-5fq1wxz8 337 2 Ammonia ammonia NN cord-283202-5fq1wxz8 337 3 may may MD cord-283202-5fq1wxz8 337 4 also also RB cord-283202-5fq1wxz8 337 5 have have VB cord-283202-5fq1wxz8 337 6 a a DT cord-283202-5fq1wxz8 337 7 direct direct JJ cord-283202-5fq1wxz8 337 8 toxic toxic JJ cord-283202-5fq1wxz8 337 9 effect effect NN cord-283202-5fq1wxz8 337 10 on on IN cord-283202-5fq1wxz8 337 11 neurons neuron NNS cord-283202-5fq1wxz8 337 12 . . . cord-283202-5fq1wxz8 338 1 110 110 CD cord-283202-5fq1wxz8 339 1 While while IN cord-283202-5fq1wxz8 339 2 ammonia ammonia NN cord-283202-5fq1wxz8 339 3 remains remain VBZ cord-283202-5fq1wxz8 339 4 a a DT cord-283202-5fq1wxz8 339 5 focal focal JJ cord-283202-5fq1wxz8 339 6 point point NN cord-283202-5fq1wxz8 339 7 in in IN cord-283202-5fq1wxz8 339 8 the the DT cord-283202-5fq1wxz8 339 9 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 339 10 of of IN cord-283202-5fq1wxz8 339 11 HE HE NNP cord-283202-5fq1wxz8 339 12 , , , cord-283202-5fq1wxz8 339 13 other other JJ cord-283202-5fq1wxz8 339 14 factors factor NNS cord-283202-5fq1wxz8 339 15 are be VBP cord-283202-5fq1wxz8 339 16 also also RB cord-283202-5fq1wxz8 339 17 involved involve VBN cord-283202-5fq1wxz8 339 18 . . . cord-283202-5fq1wxz8 340 1 Mercaptans mercaptan NNS cord-283202-5fq1wxz8 340 2 are be VBP cord-283202-5fq1wxz8 340 3 formed form VBN cord-283202-5fq1wxz8 340 4 during during IN cord-283202-5fq1wxz8 340 5 the the DT cord-283202-5fq1wxz8 340 6 degradation degradation NN cord-283202-5fq1wxz8 340 7 of of IN cord-283202-5fq1wxz8 340 8 sulfur sulfur NN cord-283202-5fq1wxz8 340 9 - - HYPH cord-283202-5fq1wxz8 340 10 containing contain VBG cord-283202-5fq1wxz8 340 11 amino amino NN cord-283202-5fq1wxz8 340 12 acids acid NNS cord-283202-5fq1wxz8 340 13 . . . cord-283202-5fq1wxz8 341 1 These these DT cord-283202-5fq1wxz8 341 2 substances substance NNS cord-283202-5fq1wxz8 341 3 exert exert VBP cord-283202-5fq1wxz8 341 4 a a DT cord-283202-5fq1wxz8 341 5 neurotoxic neurotoxic JJ cord-283202-5fq1wxz8 341 6 effect effect NN cord-283202-5fq1wxz8 341 7 through through IN cord-283202-5fq1wxz8 341 8 inhibition inhibition NN cord-283202-5fq1wxz8 341 9 of of IN cord-283202-5fq1wxz8 341 10 ATPase ATPase NNP cord-283202-5fq1wxz8 341 11 activity activity NN cord-283202-5fq1wxz8 341 12 , , , cord-283202-5fq1wxz8 341 13 thereby thereby RB cord-283202-5fq1wxz8 341 14 potentiating potentiate VBG cord-283202-5fq1wxz8 341 15 the the DT cord-283202-5fq1wxz8 341 16 effect effect NN cord-283202-5fq1wxz8 341 17 of of IN cord-283202-5fq1wxz8 341 18 ammonia ammonia NN cord-283202-5fq1wxz8 341 19 . . . cord-283202-5fq1wxz8 342 1 132 132 CD cord-283202-5fq1wxz8 342 2 Short short JJ cord-283202-5fq1wxz8 342 3 and and CC cord-283202-5fq1wxz8 342 4 medium medium JJ cord-283202-5fq1wxz8 342 5 chain chain NN cord-283202-5fq1wxz8 342 6 fatty fatty JJ cord-283202-5fq1wxz8 342 7 acids acid NNS cord-283202-5fq1wxz8 342 8 are be VBP cord-283202-5fq1wxz8 342 9 derived derive VBN cord-283202-5fq1wxz8 342 10 from from IN cord-283202-5fq1wxz8 342 11 bacterial bacterial JJ cord-283202-5fq1wxz8 342 12 metabolism metabolism NN cord-283202-5fq1wxz8 342 13 of of IN cord-283202-5fq1wxz8 342 14 carbohydrates carbohydrate NNS cord-283202-5fq1wxz8 342 15 or or CC cord-283202-5fq1wxz8 342 16 from from IN cord-283202-5fq1wxz8 342 17 incomplete incomplete JJ cord-283202-5fq1wxz8 342 18 β β NN cord-283202-5fq1wxz8 342 19 - - HYPH cord-283202-5fq1wxz8 342 20 oxidation oxidation NN cord-283202-5fq1wxz8 342 21 of of IN cord-283202-5fq1wxz8 342 22 long long JJ cord-283202-5fq1wxz8 342 23 chain chain NN cord-283202-5fq1wxz8 342 24 fatty fatty JJ cord-283202-5fq1wxz8 342 25 acids acid NNS cord-283202-5fq1wxz8 342 26 in in IN cord-283202-5fq1wxz8 342 27 the the DT cord-283202-5fq1wxz8 342 28 liver liver NN cord-283202-5fq1wxz8 342 29 . . . cord-283202-5fq1wxz8 343 1 127 127 CD cord-283202-5fq1wxz8 344 1 Like like IN cord-283202-5fq1wxz8 344 2 mercaptans mercaptan NNS cord-283202-5fq1wxz8 344 3 , , , cord-283202-5fq1wxz8 344 4 these these DT cord-283202-5fq1wxz8 344 5 molecules molecule NNS cord-283202-5fq1wxz8 344 6 may may MD cord-283202-5fq1wxz8 344 7 inhibit inhibit VB cord-283202-5fq1wxz8 344 8 energy energy NN cord-283202-5fq1wxz8 344 9 metabolism metabolism NN cord-283202-5fq1wxz8 344 10 as as RB cord-283202-5fq1wxz8 344 11 well well RB cord-283202-5fq1wxz8 344 12 as as IN cord-283202-5fq1wxz8 344 13 inhibiting inhibit VBG cord-283202-5fq1wxz8 344 14 urea urea NN cord-283202-5fq1wxz8 344 15 cycle cycle NN cord-283202-5fq1wxz8 344 16 enzymes enzyme NNS cord-283202-5fq1wxz8 344 17 in in IN cord-283202-5fq1wxz8 344 18 the the DT cord-283202-5fq1wxz8 344 19 liver liver NN cord-283202-5fq1wxz8 344 20 . . . cord-283202-5fq1wxz8 345 1 126 126 CD cord-283202-5fq1wxz8 346 1 A a DT cord-283202-5fq1wxz8 346 2 putative putative JJ cord-283202-5fq1wxz8 346 3 role role NN cord-283202-5fq1wxz8 346 4 for for IN cord-283202-5fq1wxz8 346 5 mercaptans mercaptan NNS cord-283202-5fq1wxz8 346 6 , , , cord-283202-5fq1wxz8 346 7 short short JJ cord-283202-5fq1wxz8 346 8 and and CC cord-283202-5fq1wxz8 346 9 long long JJ cord-283202-5fq1wxz8 346 10 chain chain NN cord-283202-5fq1wxz8 346 11 fatty fatty JJ cord-283202-5fq1wxz8 346 12 acids acid NNS cord-283202-5fq1wxz8 346 13 is be VBZ cord-283202-5fq1wxz8 346 14 unknown unknown JJ cord-283202-5fq1wxz8 346 15 , , , cord-283202-5fq1wxz8 346 16 but but CC cord-283202-5fq1wxz8 346 17 they -PRON- PRP cord-283202-5fq1wxz8 346 18 may may MD cord-283202-5fq1wxz8 346 19 act act VB cord-283202-5fq1wxz8 346 20 synergistically synergistically RB cord-283202-5fq1wxz8 346 21 with with IN cord-283202-5fq1wxz8 346 22 ammonia ammonia NN cord-283202-5fq1wxz8 346 23 . . . cord-283202-5fq1wxz8 347 1 127 127 CD cord-283202-5fq1wxz8 347 2 Hepatic hepatic JJ cord-283202-5fq1wxz8 347 3 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 347 4 may may MD cord-283202-5fq1wxz8 347 5 develop develop VB cord-283202-5fq1wxz8 347 6 through through IN cord-283202-5fq1wxz8 347 7 an an DT cord-283202-5fq1wxz8 347 8 imbalance imbalance NN cord-283202-5fq1wxz8 347 9 of of IN cord-283202-5fq1wxz8 347 10 inhibitory inhibitory JJ cord-283202-5fq1wxz8 347 11 ( ( -LRB- cord-283202-5fq1wxz8 347 12 GABA GABA NNP cord-283202-5fq1wxz8 347 13 ) ) -RRB- cord-283202-5fq1wxz8 347 14 and and CC cord-283202-5fq1wxz8 347 15 excitatory excitatory JJ cord-283202-5fq1wxz8 347 16 ( ( -LRB- cord-283202-5fq1wxz8 347 17 glutamate glutamate NN cord-283202-5fq1wxz8 347 18 ) ) -RRB- cord-283202-5fq1wxz8 347 19 neuro neuro NNP cord-283202-5fq1wxz8 347 20 transmitters transmitter NNS cord-283202-5fq1wxz8 347 21 . . . cord-283202-5fq1wxz8 348 1 133 133 CD cord-283202-5fq1wxz8 349 1 There there EX cord-283202-5fq1wxz8 349 2 is be VBZ cord-283202-5fq1wxz8 349 3 evidence evidence NN cord-283202-5fq1wxz8 349 4 to to TO cord-283202-5fq1wxz8 349 5 implicate implicate VB cord-283202-5fq1wxz8 349 6 exces- exces- FW cord-283202-5fq1wxz8 349 7 sive sive JJ cord-283202-5fq1wxz8 349 8 GABAergic GABAergic NNP cord-283202-5fq1wxz8 349 9 tone tone NN cord-283202-5fq1wxz8 349 10 in in IN cord-283202-5fq1wxz8 349 11 HE HE NNP cord-283202-5fq1wxz8 349 12 , , , cord-283202-5fq1wxz8 349 13 which which WDT cord-283202-5fq1wxz8 349 14 would would MD cord-283202-5fq1wxz8 349 15 result result VB cord-283202-5fq1wxz8 349 16 in in IN cord-283202-5fq1wxz8 349 17 global global JJ cord-283202-5fq1wxz8 349 18 inhibition inhibition NN cord-283202-5fq1wxz8 349 19 of of IN cord-283202-5fq1wxz8 349 20 neurological neurological JJ cord-283202-5fq1wxz8 349 21 function function NN cord-283202-5fq1wxz8 349 22 . . . cord-283202-5fq1wxz8 350 1 133 133 CD cord-283202-5fq1wxz8 351 1 In in IN cord-283202-5fq1wxz8 351 2 humans human NNS cord-283202-5fq1wxz8 351 3 with with IN cord-283202-5fq1wxz8 351 4 HE HE NNP cord-283202-5fq1wxz8 351 5 , , , cord-283202-5fq1wxz8 351 6 there there EX cord-283202-5fq1wxz8 351 7 are be VBP cord-283202-5fq1wxz8 351 8 increased increase VBN cord-283202-5fq1wxz8 351 9 GABA GABA NNP cord-283202-5fq1wxz8 351 10 concentrations concentration NNS cord-283202-5fq1wxz8 351 11 in in IN cord-283202-5fq1wxz8 351 12 the the DT cord-283202-5fq1wxz8 351 13 CNS CNS NNP cord-283202-5fq1wxz8 351 14 leading lead VBG cord-283202-5fq1wxz8 351 15 to to IN cord-283202-5fq1wxz8 351 16 excessive excessive JJ cord-283202-5fq1wxz8 351 17 GABAergic gabaergic NN cord-283202-5fq1wxz8 351 18 tone tone NN cord-283202-5fq1wxz8 351 19 . . . cord-283202-5fq1wxz8 352 1 134 134 CD cord-283202-5fq1wxz8 353 1 In in IN cord-283202-5fq1wxz8 353 2 addition addition NN cord-283202-5fq1wxz8 353 3 , , , cord-283202-5fq1wxz8 353 4 there there EX cord-283202-5fq1wxz8 353 5 may may MD cord-283202-5fq1wxz8 353 6 also also RB cord-283202-5fq1wxz8 353 7 be be VB cord-283202-5fq1wxz8 353 8 increased increase VBN cord-283202-5fq1wxz8 353 9 concentrations concentration NNS cord-283202-5fq1wxz8 353 10 of of IN cord-283202-5fq1wxz8 353 11 endogenous endogenous JJ cord-283202-5fq1wxz8 353 12 benzodiazepines benzodiazepine NNS cord-283202-5fq1wxz8 353 13 in in IN cord-283202-5fq1wxz8 353 14 the the DT cord-283202-5fq1wxz8 353 15 CNS CNS NNP cord-283202-5fq1wxz8 353 16 . . . cord-283202-5fq1wxz8 354 1 127 127 CD cord-283202-5fq1wxz8 354 2 , , , cord-283202-5fq1wxz8 354 3 133 133 CD cord-283202-5fq1wxz8 354 4 Benzodiazepines benzodiazepine NNS cord-283202-5fq1wxz8 354 5 also also RB cord-283202-5fq1wxz8 354 6 bind bind VBP cord-283202-5fq1wxz8 354 7 to to IN cord-283202-5fq1wxz8 354 8 the the DT cord-283202-5fq1wxz8 354 9 GABA GABA NNP cord-283202-5fq1wxz8 354 10 receptor receptor NN cord-283202-5fq1wxz8 354 11 , , , cord-283202-5fq1wxz8 354 12 potentiating potentiate VBG cord-283202-5fq1wxz8 354 13 the the DT cord-283202-5fq1wxz8 354 14 effect effect NN cord-283202-5fq1wxz8 354 15 of of IN cord-283202-5fq1wxz8 354 16 GABA GABA NNP cord-283202-5fq1wxz8 354 17 . . . cord-283202-5fq1wxz8 355 1 126 126 CD cord-283202-5fq1wxz8 355 2 False false JJ cord-283202-5fq1wxz8 355 3 neurotransmitters neurotransmitter NNS cord-283202-5fq1wxz8 355 4 may may MD cord-283202-5fq1wxz8 355 5 also also RB cord-283202-5fq1wxz8 355 6 play play VB cord-283202-5fq1wxz8 355 7 a a DT cord-283202-5fq1wxz8 355 8 role role NN cord-283202-5fq1wxz8 355 9 in in IN cord-283202-5fq1wxz8 355 10 HE HE NNP cord-283202-5fq1wxz8 355 11 . . . cord-283202-5fq1wxz8 356 1 126 126 CD cord-283202-5fq1wxz8 357 1 In in IN cord-283202-5fq1wxz8 357 2 liver liver NN cord-283202-5fq1wxz8 357 3 disease disease NN cord-283202-5fq1wxz8 357 4 , , , cord-283202-5fq1wxz8 357 5 the the DT cord-283202-5fq1wxz8 357 6 production production NN cord-283202-5fq1wxz8 357 7 of of IN cord-283202-5fq1wxz8 357 8 branched branched JJ cord-283202-5fq1wxz8 357 9 chain chain NN cord-283202-5fq1wxz8 357 10 amino amino NN cord-283202-5fq1wxz8 357 11 acids acid NNS cord-283202-5fq1wxz8 357 12 is be VBZ cord-283202-5fq1wxz8 357 13 reduced reduce VBN cord-283202-5fq1wxz8 357 14 . . . cord-283202-5fq1wxz8 358 1 127 127 CD cord-283202-5fq1wxz8 359 1 Branched branched JJ cord-283202-5fq1wxz8 359 2 and and CC cord-283202-5fq1wxz8 359 3 aromatic aromatic JJ cord-283202-5fq1wxz8 359 4 amino amino NN cord-283202-5fq1wxz8 359 5 acids acid NNS cord-283202-5fq1wxz8 359 6 compete compete VBP cord-283202-5fq1wxz8 359 7 for for IN cord-283202-5fq1wxz8 359 8 the the DT cord-283202-5fq1wxz8 359 9 same same JJ cord-283202-5fq1wxz8 359 10 transporter transporter NN cord-283202-5fq1wxz8 359 11 into into IN cord-283202-5fq1wxz8 359 12 the the DT cord-283202-5fq1wxz8 359 13 CNS CNS NNP cord-283202-5fq1wxz8 359 14 . . . cord-283202-5fq1wxz8 360 1 126 126 CD cord-283202-5fq1wxz8 361 1 As as IN cord-283202-5fq1wxz8 361 2 a a DT cord-283202-5fq1wxz8 361 3 consequence consequence NN cord-283202-5fq1wxz8 361 4 of of IN cord-283202-5fq1wxz8 361 5 reduced reduce VBN cord-283202-5fq1wxz8 361 6 branched branched JJ cord-283202-5fq1wxz8 361 7 chain chain NN cord-283202-5fq1wxz8 361 8 amino amino NN cord-283202-5fq1wxz8 361 9 acids acid NNS cord-283202-5fq1wxz8 361 10 , , , cord-283202-5fq1wxz8 361 11 there there EX cord-283202-5fq1wxz8 361 12 may may MD cord-283202-5fq1wxz8 361 13 be be VB cord-283202-5fq1wxz8 361 14 a a DT cord-283202-5fq1wxz8 361 15 relative relative JJ cord-283202-5fq1wxz8 361 16 increase increase NN cord-283202-5fq1wxz8 361 17 in in IN cord-283202-5fq1wxz8 361 18 the the DT cord-283202-5fq1wxz8 361 19 aromatic aromatic JJ cord-283202-5fq1wxz8 361 20 amino amino NN cord-283202-5fq1wxz8 361 21 acids acid NNS cord-283202-5fq1wxz8 361 22 ; ; : cord-283202-5fq1wxz8 361 23 these these DT cord-283202-5fq1wxz8 361 24 so so RB cord-283202-5fq1wxz8 361 25 - - HYPH cord-283202-5fq1wxz8 361 26 called call VBN cord-283202-5fq1wxz8 361 27 false false JJ cord-283202-5fq1wxz8 361 28 neurotransmitters neurotransmitter NNS cord-283202-5fq1wxz8 361 29 may may MD cord-283202-5fq1wxz8 361 30 act act VB cord-283202-5fq1wxz8 361 31 like like IN cord-283202-5fq1wxz8 361 32 GABA GABA NNP cord-283202-5fq1wxz8 361 33 and and CC cord-283202-5fq1wxz8 361 34 other other JJ cord-283202-5fq1wxz8 361 35 inhibitory inhibitory JJ cord-283202-5fq1wxz8 361 36 neurotransmitters neurotransmitter NNS cord-283202-5fq1wxz8 361 37 . . . cord-283202-5fq1wxz8 362 1 135 135 CD cord-283202-5fq1wxz8 363 1 Ultimately ultimately RB cord-283202-5fq1wxz8 363 2 , , , cord-283202-5fq1wxz8 363 3 the the DT cord-283202-5fq1wxz8 363 4 clinical clinical JJ cord-283202-5fq1wxz8 363 5 signs sign NNS cord-283202-5fq1wxz8 363 6 of of IN cord-283202-5fq1wxz8 363 7 HE he PRP cord-283202-5fq1wxz8 363 8 may may MD cord-283202-5fq1wxz8 363 9 be be VB cord-283202-5fq1wxz8 363 10 a a DT cord-283202-5fq1wxz8 363 11 result result NN cord-283202-5fq1wxz8 363 12 of of IN cord-283202-5fq1wxz8 363 13 global global JJ cord-283202-5fq1wxz8 363 14 inhibition inhibition NN cord-283202-5fq1wxz8 363 15 of of IN cord-283202-5fq1wxz8 363 16 neurotransmission neurotransmission NN cord-283202-5fq1wxz8 363 17 . . . cord-283202-5fq1wxz8 364 1 A a DT cord-283202-5fq1wxz8 364 2 complete complete JJ cord-283202-5fq1wxz8 364 3 blood blood NN cord-283202-5fq1wxz8 364 4 count count NN cord-283202-5fq1wxz8 364 5 , , , cord-283202-5fq1wxz8 364 6 biochemistry biochemistry NN cord-283202-5fq1wxz8 364 7 and and CC cord-283202-5fq1wxz8 364 8 urinalysis urinalysis NN cord-283202-5fq1wxz8 364 9 should should MD cord-283202-5fq1wxz8 364 10 be be VB cord-283202-5fq1wxz8 364 11 performed perform VBN cord-283202-5fq1wxz8 364 12 in in IN cord-283202-5fq1wxz8 364 13 all all DT cord-283202-5fq1wxz8 364 14 animals animal NNS cord-283202-5fq1wxz8 364 15 with with IN cord-283202-5fq1wxz8 364 16 clinical clinical JJ cord-283202-5fq1wxz8 364 17 signs sign NNS cord-283202-5fq1wxz8 364 18 suggestive suggestive JJ cord-283202-5fq1wxz8 364 19 of of IN cord-283202-5fq1wxz8 364 20 HE he PRP cord-283202-5fq1wxz8 364 21 . . . cord-283202-5fq1wxz8 365 1 On on IN cord-283202-5fq1wxz8 365 2 hema hema NNP cord-283202-5fq1wxz8 365 3 tol tol NNP cord-283202-5fq1wxz8 365 4 ogy ogy NNP cord-283202-5fq1wxz8 365 5 , , , cord-283202-5fq1wxz8 365 6 microcytosis microcytosis NNP cord-283202-5fq1wxz8 365 7 may may MD cord-283202-5fq1wxz8 365 8 be be VB cord-283202-5fq1wxz8 365 9 present present JJ cord-283202-5fq1wxz8 365 10 . . . cord-283202-5fq1wxz8 366 1 112 112 CD cord-283202-5fq1wxz8 366 2 Biochemical biochemical JJ cord-283202-5fq1wxz8 366 3 abnormalities abnormality NNS cord-283202-5fq1wxz8 366 4 may may MD cord-283202-5fq1wxz8 366 5 include include VB cord-283202-5fq1wxz8 366 6 low low JJ cord-283202-5fq1wxz8 366 7 blood blood NN cord-283202-5fq1wxz8 366 8 urea urea NN cord-283202-5fq1wxz8 366 9 nitrogen nitrogen NN cord-283202-5fq1wxz8 366 10 , , , cord-283202-5fq1wxz8 366 11 increased increase VBN cord-283202-5fq1wxz8 366 12 liver liver NN cord-283202-5fq1wxz8 366 13 enzymes enzyme NNS cord-283202-5fq1wxz8 366 14 , , , cord-283202-5fq1wxz8 366 15 decreased decrease VBD cord-283202-5fq1wxz8 366 16 total total JJ cord-283202-5fq1wxz8 366 17 protein protein NN cord-283202-5fq1wxz8 366 18 and and CC cord-283202-5fq1wxz8 366 19 albumin albumin NN cord-283202-5fq1wxz8 366 20 concentrations concentration NNS cord-283202-5fq1wxz8 366 21 , , , cord-283202-5fq1wxz8 366 22 and and CC cord-283202-5fq1wxz8 366 23 hypocholesterolemia hypocholesterolemia NN cord-283202-5fq1wxz8 366 24 . . . cord-283202-5fq1wxz8 367 1 112 112 CD cord-283202-5fq1wxz8 367 2 Urinalysis Urinalysis NNP cord-283202-5fq1wxz8 367 3 may may MD cord-283202-5fq1wxz8 367 4 disclose disclose VB cord-283202-5fq1wxz8 367 5 hyposthenuria hyposthenuria NNP cord-283202-5fq1wxz8 367 6 and and CC cord-283202-5fq1wxz8 367 7 ammonium ammonium NN cord-283202-5fq1wxz8 367 8 urate urate NN cord-283202-5fq1wxz8 367 9 crystals crystal NNS cord-283202-5fq1wxz8 367 10 . . . cord-283202-5fq1wxz8 368 1 112 112 CD cord-283202-5fq1wxz8 369 1 A a DT cord-283202-5fq1wxz8 369 2 presumptive presumptive JJ cord-283202-5fq1wxz8 369 3 diagnosis diagnosis NN cord-283202-5fq1wxz8 369 4 can can MD cord-283202-5fq1wxz8 369 5 be be VB cord-283202-5fq1wxz8 369 6 made make VBN cord-283202-5fq1wxz8 369 7 by by IN cord-283202-5fq1wxz8 369 8 documenting document VBG cord-283202-5fq1wxz8 369 9 altered alter VBN cord-283202-5fq1wxz8 369 10 liver liver NN cord-283202-5fq1wxz8 369 11 function function NN cord-283202-5fq1wxz8 369 12 in in IN cord-283202-5fq1wxz8 369 13 the the DT cord-283202-5fq1wxz8 369 14 setting setting NN cord-283202-5fq1wxz8 369 15 of of IN cord-283202-5fq1wxz8 369 16 clinical clinical JJ cord-283202-5fq1wxz8 369 17 signs sign NNS cord-283202-5fq1wxz8 369 18 consistent consistent JJ cord-283202-5fq1wxz8 369 19 with with IN cord-283202-5fq1wxz8 369 20 HE he PRP cord-283202-5fq1wxz8 369 21 . . . cord-283202-5fq1wxz8 370 1 An an DT cord-283202-5fq1wxz8 370 2 elevated elevated JJ cord-283202-5fq1wxz8 370 3 fasting fast VBG cord-283202-5fq1wxz8 370 4 blood blood NN cord-283202-5fq1wxz8 370 5 ammonia ammonia NN cord-283202-5fq1wxz8 370 6 level level NN cord-283202-5fq1wxz8 370 7 helps help VBZ cord-283202-5fq1wxz8 370 8 confirm confirm VB cord-283202-5fq1wxz8 370 9 the the DT cord-283202-5fq1wxz8 370 10 clinical clinical JJ cord-283202-5fq1wxz8 370 11 suspicion suspicion NN cord-283202-5fq1wxz8 370 12 . . . cord-283202-5fq1wxz8 371 1 In in IN cord-283202-5fq1wxz8 371 2 order order NN cord-283202-5fq1wxz8 371 3 to to TO cord-283202-5fq1wxz8 371 4 provide provide VB cord-283202-5fq1wxz8 371 5 accurate accurate JJ cord-283202-5fq1wxz8 371 6 results result NNS cord-283202-5fq1wxz8 371 7 , , , cord-283202-5fq1wxz8 371 8 blood blood NN cord-283202-5fq1wxz8 371 9 samples sample NNS cord-283202-5fq1wxz8 371 10 should should MD cord-283202-5fq1wxz8 371 11 be be VB cord-283202-5fq1wxz8 371 12 Treatment treatment NN cord-283202-5fq1wxz8 371 13 should should MD cord-283202-5fq1wxz8 371 14 be be VB cord-283202-5fq1wxz8 371 15 directed direct VBN cord-283202-5fq1wxz8 371 16 at at IN cord-283202-5fq1wxz8 371 17 the the DT cord-283202-5fq1wxz8 371 18 underlying underlying JJ cord-283202-5fq1wxz8 371 19 cause cause NN cord-283202-5fq1wxz8 371 20 of of IN cord-283202-5fq1wxz8 371 21 HE he PRP cord-283202-5fq1wxz8 371 22 as as RB cord-283202-5fq1wxz8 371 23 well well RB cord-283202-5fq1wxz8 371 24 as as IN cord-283202-5fq1wxz8 371 25 controlling control VBG cord-283202-5fq1wxz8 371 26 the the DT cord-283202-5fq1wxz8 371 27 clinical clinical JJ cord-283202-5fq1wxz8 371 28 signs sign NNS cord-283202-5fq1wxz8 371 29 of of IN cord-283202-5fq1wxz8 371 30 HE he PRP cord-283202-5fq1wxz8 371 31 . . . cord-283202-5fq1wxz8 372 1 One one CD cord-283202-5fq1wxz8 372 2 of of IN cord-283202-5fq1wxz8 372 3 the the DT cord-283202-5fq1wxz8 372 4 primary primary JJ cord-283202-5fq1wxz8 372 5 aims aim NNS cord-283202-5fq1wxz8 372 6 is be VBZ cord-283202-5fq1wxz8 372 7 to to TO cord-283202-5fq1wxz8 372 8 reduce reduce VB cord-283202-5fq1wxz8 372 9 blood blood NN cord-283202-5fq1wxz8 372 10 ammonia ammonia NN cord-283202-5fq1wxz8 372 11 levels level NNS cord-283202-5fq1wxz8 372 12 . . . cord-283202-5fq1wxz8 373 1 For for IN cord-283202-5fq1wxz8 373 2 animals animal NNS cord-283202-5fq1wxz8 373 3 with with IN cord-283202-5fq1wxz8 373 4 mild mild JJ cord-283202-5fq1wxz8 373 5 to to IN cord-283202-5fq1wxz8 373 6 moderately moderately RB cord-283202-5fq1wxz8 373 7 severe severe JJ cord-283202-5fq1wxz8 373 8 clinical clinical JJ cord-283202-5fq1wxz8 373 9 signs sign NNS cord-283202-5fq1wxz8 373 10 , , , cord-283202-5fq1wxz8 373 11 which which WDT cord-283202-5fq1wxz8 373 12 are be VBP cord-283202-5fq1wxz8 373 13 capable capable JJ cord-283202-5fq1wxz8 373 14 of of IN cord-283202-5fq1wxz8 373 15 taking take VBG cord-283202-5fq1wxz8 373 16 oral oral JJ cord-283202-5fq1wxz8 373 17 medications medication NNS cord-283202-5fq1wxz8 373 18 , , , cord-283202-5fq1wxz8 373 19 lactulose lactulose NN cord-283202-5fq1wxz8 373 20 should should MD cord-283202-5fq1wxz8 373 21 be be VB cord-283202-5fq1wxz8 373 22 administered administer VBN cord-283202-5fq1wxz8 373 23 at at IN cord-283202-5fq1wxz8 373 24 a a DT cord-283202-5fq1wxz8 373 25 starting starting NN cord-283202-5fq1wxz8 373 26 dose dose NN cord-283202-5fq1wxz8 373 27 of of IN cord-283202-5fq1wxz8 373 28 1 1 CD cord-283202-5fq1wxz8 373 29 ml ml NN cord-283202-5fq1wxz8 373 30 PO po NN cord-283202-5fq1wxz8 373 31 q q NNP cord-283202-5fq1wxz8 373 32 8 8 CD cord-283202-5fq1wxz8 373 33 - - SYM cord-283202-5fq1wxz8 373 34 12 12 CD cord-283202-5fq1wxz8 373 35 h. h. NN cord-283202-5fq1wxz8 373 36 116 116 CD cord-283202-5fq1wxz8 374 1 The the DT cord-283202-5fq1wxz8 374 2 dosage dosage NN cord-283202-5fq1wxz8 374 3 is be VBZ cord-283202-5fq1wxz8 374 4 adjusted adjust VBN cord-283202-5fq1wxz8 374 5 based base VBN cord-283202-5fq1wxz8 374 6 on on IN cord-283202-5fq1wxz8 374 7 stool stool NN cord-283202-5fq1wxz8 374 8 consistency consistency NN cord-283202-5fq1wxz8 374 9 and and CC cord-283202-5fq1wxz8 374 10 response response NN cord-283202-5fq1wxz8 374 11 . . . cord-283202-5fq1wxz8 375 1 In in IN cord-283202-5fq1wxz8 375 2 more more RBR cord-283202-5fq1wxz8 375 3 severely severely RB cord-283202-5fq1wxz8 375 4 affected affect VBN cord-283202-5fq1wxz8 375 5 cats cat NNS cord-283202-5fq1wxz8 375 6 , , , cord-283202-5fq1wxz8 375 7 lactulose lactulose NN cord-283202-5fq1wxz8 375 8 can can MD cord-283202-5fq1wxz8 375 9 also also RB cord-283202-5fq1wxz8 375 10 be be VB cord-283202-5fq1wxz8 375 11 administered administer VBN cord-283202-5fq1wxz8 375 12 per per IN cord-283202-5fq1wxz8 375 13 rectum rectum NN cord-283202-5fq1wxz8 375 14 . . . cord-283202-5fq1wxz8 376 1 Prior prior RB cord-283202-5fq1wxz8 376 2 to to IN cord-283202-5fq1wxz8 376 3 rectal rectal JJ cord-283202-5fq1wxz8 376 4 administration administration NN cord-283202-5fq1wxz8 376 5 , , , cord-283202-5fq1wxz8 376 6 warm warm JJ cord-283202-5fq1wxz8 376 7 water water NN cord-283202-5fq1wxz8 376 8 enemas enema NNS cord-283202-5fq1wxz8 376 9 should should MD cord-283202-5fq1wxz8 376 10 be be VB cord-283202-5fq1wxz8 376 11 performed perform VBN cord-283202-5fq1wxz8 376 12 to to TO cord-283202-5fq1wxz8 376 13 remove remove VB cord-283202-5fq1wxz8 376 14 fecal fecal JJ cord-283202-5fq1wxz8 376 15 material material NN cord-283202-5fq1wxz8 376 16 . . . cord-283202-5fq1wxz8 377 1 Lactulose Lactulose NNP cord-283202-5fq1wxz8 377 2 is be VBZ cord-283202-5fq1wxz8 377 3 a a DT cord-283202-5fq1wxz8 377 4 non non JJ cord-283202-5fq1wxz8 377 5 - - JJ cord-283202-5fq1wxz8 377 6 aborbable aborbable JJ cord-283202-5fq1wxz8 377 7 disaccharide disaccharide NN cord-283202-5fq1wxz8 377 8 that that WDT cord-283202-5fq1wxz8 377 9 undergoes undergo VBZ cord-283202-5fq1wxz8 377 10 extensive extensive JJ cord-283202-5fq1wxz8 377 11 metabolism metabolism NN cord-283202-5fq1wxz8 377 12 by by IN cord-283202-5fq1wxz8 377 13 colonic colonic JJ cord-283202-5fq1wxz8 377 14 bacteria bacteria NNS cord-283202-5fq1wxz8 377 15 , , , cord-283202-5fq1wxz8 377 16 first first RB cord-283202-5fq1wxz8 377 17 to to IN cord-283202-5fq1wxz8 377 18 constituent constituent NN cord-283202-5fq1wxz8 377 19 monosaccharides monosaccharide NNS cord-283202-5fq1wxz8 377 20 and and CC cord-283202-5fq1wxz8 377 21 then then RB cord-283202-5fq1wxz8 377 22 to to IN cord-283202-5fq1wxz8 377 23 volatile volatile JJ cord-283202-5fq1wxz8 377 24 fatty fatty JJ cord-283202-5fq1wxz8 377 25 acids acid NNS cord-283202-5fq1wxz8 377 26 . . . cord-283202-5fq1wxz8 378 1 140 140 CD cord-283202-5fq1wxz8 379 1 Ultimately ultimately RB cord-283202-5fq1wxz8 379 2 , , , cord-283202-5fq1wxz8 379 3 lactulose lactulose NN cord-283202-5fq1wxz8 379 4 decreases decrease VBZ cord-283202-5fq1wxz8 379 5 the the DT cord-283202-5fq1wxz8 379 6 production production NN cord-283202-5fq1wxz8 379 7 / / SYM cord-283202-5fq1wxz8 379 8 absorption absorption NN cord-283202-5fq1wxz8 379 9 of of IN cord-283202-5fq1wxz8 379 10 ammonia ammonia NN cord-283202-5fq1wxz8 379 11 . . . cord-283202-5fq1wxz8 380 1 140 140 CD cord-283202-5fq1wxz8 381 1 This this DT cord-283202-5fq1wxz8 381 2 is be VBZ cord-283202-5fq1wxz8 381 3 accomplished accomplish VBN cord-283202-5fq1wxz8 381 4 in in IN cord-283202-5fq1wxz8 381 5 several several JJ cord-283202-5fq1wxz8 381 6 ways way NNS cord-283202-5fq1wxz8 381 7 : : : cord-283202-5fq1wxz8 381 8 namely namely RB cord-283202-5fq1wxz8 381 9 , , , cord-283202-5fq1wxz8 381 10 by by IN cord-283202-5fq1wxz8 381 11 decreasing decrease VBG cord-283202-5fq1wxz8 381 12 the the DT cord-283202-5fq1wxz8 381 13 colonic colonic JJ cord-283202-5fq1wxz8 381 14 luminal luminal JJ cord-283202-5fq1wxz8 381 15 pH pH NNP cord-283202-5fq1wxz8 381 16 , , , cord-283202-5fq1wxz8 381 17 leading lead VBG cord-283202-5fq1wxz8 381 18 to to IN cord-283202-5fq1wxz8 381 19 conversion conversion NN cord-283202-5fq1wxz8 381 20 of of IN cord-283202-5fq1wxz8 381 21 ammonia ammonia NN cord-283202-5fq1wxz8 381 22 ( ( -LRB- cord-283202-5fq1wxz8 381 23 NH NH NNP cord-283202-5fq1wxz8 381 24 3 3 CD cord-283202-5fq1wxz8 381 25 ) ) -RRB- cord-283202-5fq1wxz8 381 26 to to IN cord-283202-5fq1wxz8 381 27 ammonium ammonium NN cord-283202-5fq1wxz8 381 28 ( ( -LRB- cord-283202-5fq1wxz8 381 29 NH NH NNP cord-283202-5fq1wxz8 381 30 4 4 CD cord-283202-5fq1wxz8 381 31 + + SYM cord-283202-5fq1wxz8 381 32 ) ) -RRB- cord-283202-5fq1wxz8 381 33 , , , cord-283202-5fq1wxz8 381 34 trapping trap VBG cord-283202-5fq1wxz8 381 35 it -PRON- PRP cord-283202-5fq1wxz8 381 36 intraluminally intraluminally RB cord-283202-5fq1wxz8 381 37 ; ; : cord-283202-5fq1wxz8 381 38 decreasing decrease VBG cord-283202-5fq1wxz8 381 39 transit transit NN cord-283202-5fq1wxz8 381 40 time time NN cord-283202-5fq1wxz8 381 41 through through IN cord-283202-5fq1wxz8 381 42 the the DT cord-283202-5fq1wxz8 381 43 osmotic osmotic JJ cord-283202-5fq1wxz8 381 44 cathartic cathartic JJ cord-283202-5fq1wxz8 381 45 effect effect NN cord-283202-5fq1wxz8 381 46 of of IN cord-283202-5fq1wxz8 381 47 lactulose lactulose NN cord-283202-5fq1wxz8 381 48 ; ; : cord-283202-5fq1wxz8 381 49 and and CC cord-283202-5fq1wxz8 381 50 interfering interfere VBG cord-283202-5fq1wxz8 381 51 with with IN cord-283202-5fq1wxz8 381 52 intestinal intestinal JJ cord-283202-5fq1wxz8 381 53 absorption absorption NN cord-283202-5fq1wxz8 381 54 of of IN cord-283202-5fq1wxz8 381 55 glutamine glutamine NN cord-283202-5fq1wxz8 381 56 , , , cord-283202-5fq1wxz8 381 57 thereby thereby RB cord-283202-5fq1wxz8 381 58 decreasing decrease VBG cord-283202-5fq1wxz8 381 59 the the DT cord-283202-5fq1wxz8 381 60 production production NN cord-283202-5fq1wxz8 381 61 of of IN cord-283202-5fq1wxz8 381 62 ammonia ammonia NN cord-283202-5fq1wxz8 381 63 . . . cord-283202-5fq1wxz8 382 1 141 141 CD cord-283202-5fq1wxz8 382 2 Antibiotic antibiotic JJ cord-283202-5fq1wxz8 382 3 therapy therapy NN cord-283202-5fq1wxz8 382 4 is be VBZ cord-283202-5fq1wxz8 382 5 often often RB cord-283202-5fq1wxz8 382 6 combined combine VBN cord-283202-5fq1wxz8 382 7 with with IN cord-283202-5fq1wxz8 382 8 lactulose lactulose NNP cord-283202-5fq1wxz8 382 9 administration administration NN cord-283202-5fq1wxz8 382 10 . . . cord-283202-5fq1wxz8 383 1 Antibiotics antibiotic NNS cord-283202-5fq1wxz8 383 2 with with IN cord-283202-5fq1wxz8 383 3 activity activity NN cord-283202-5fq1wxz8 383 4 against against IN cord-283202-5fq1wxz8 383 5 ureaseproducing ureaseproduce VBG cord-283202-5fq1wxz8 383 6 bacteria bacteria NNS cord-283202-5fq1wxz8 383 7 are be VBP cord-283202-5fq1wxz8 383 8 effective effective JJ cord-283202-5fq1wxz8 383 9 at at IN cord-283202-5fq1wxz8 383 10 reducing reduce VBG cord-283202-5fq1wxz8 383 11 ammonia ammonia NN cord-283202-5fq1wxz8 383 12 production production NN cord-283202-5fq1wxz8 383 13 . . . cord-283202-5fq1wxz8 384 1 Neomycin Neomycin NNP cord-283202-5fq1wxz8 384 2 is be VBZ cord-283202-5fq1wxz8 384 3 an an DT cord-283202-5fq1wxz8 384 4 oral oral JJ cord-283202-5fq1wxz8 384 5 aminoglycoside aminoglycoside NN cord-283202-5fq1wxz8 384 6 antibiotic antibiotic NN cord-283202-5fq1wxz8 384 7 that that WDT cord-283202-5fq1wxz8 384 8 undergoes undergo VBZ cord-283202-5fq1wxz8 384 9 minimal minimal JJ cord-283202-5fq1wxz8 384 10 systemic systemic JJ cord-283202-5fq1wxz8 384 11 absorption absorption NN cord-283202-5fq1wxz8 384 12 . . . cord-283202-5fq1wxz8 385 1 It -PRON- PRP cord-283202-5fq1wxz8 385 2 is be VBZ cord-283202-5fq1wxz8 385 3 administered administer VBN cord-283202-5fq1wxz8 385 4 at at IN cord-283202-5fq1wxz8 385 5 20 20 CD cord-283202-5fq1wxz8 385 6 mg mg NN cord-283202-5fq1wxz8 385 7 / / SYM cord-283202-5fq1wxz8 385 8 kg kg NNP cord-283202-5fq1wxz8 385 9 PO po NN cord-283202-5fq1wxz8 385 10 q q NNP cord-283202-5fq1wxz8 385 11 8 8 CD cord-283202-5fq1wxz8 385 12 h. h. NN cord-283202-5fq1wxz8 385 13 116 116 CD cord-283202-5fq1wxz8 386 1 Despite despite IN cord-283202-5fq1wxz8 386 2 the the DT cord-283202-5fq1wxz8 386 3 limited limited JJ cord-283202-5fq1wxz8 386 4 systemic systemic JJ cord-283202-5fq1wxz8 386 5 absorption absorption NN cord-283202-5fq1wxz8 386 6 , , , cord-283202-5fq1wxz8 386 7 systemic systemic JJ cord-283202-5fq1wxz8 386 8 concentrations concentration NNS cord-283202-5fq1wxz8 386 9 capable capable JJ cord-283202-5fq1wxz8 386 10 of of IN cord-283202-5fq1wxz8 386 11 causing cause VBG cord-283202-5fq1wxz8 386 12 side side NN cord-283202-5fq1wxz8 386 13 effects effect NNS cord-283202-5fq1wxz8 386 14 are be VBP cord-283202-5fq1wxz8 386 15 possible possible JJ cord-283202-5fq1wxz8 386 16 . . . cord-283202-5fq1wxz8 387 1 116 116 CD cord-283202-5fq1wxz8 387 2 Metronidazole Metronidazole NNP cord-283202-5fq1wxz8 387 3 is be VBZ cord-283202-5fq1wxz8 387 4 also also RB cord-283202-5fq1wxz8 387 5 effective effective JJ cord-283202-5fq1wxz8 387 6 at at IN cord-283202-5fq1wxz8 387 7 reducing reduce VBG cord-283202-5fq1wxz8 387 8 urease urease NN cord-283202-5fq1wxz8 387 9 - - HYPH cord-283202-5fq1wxz8 387 10 producing produce VBG cord-283202-5fq1wxz8 387 11 microbes microbe NNS cord-283202-5fq1wxz8 387 12 , , , cord-283202-5fq1wxz8 387 13 and and CC cord-283202-5fq1wxz8 387 14 is be VBZ cord-283202-5fq1wxz8 387 15 administered administer VBN cord-283202-5fq1wxz8 387 16 at at IN cord-283202-5fq1wxz8 387 17 10 10 CD cord-283202-5fq1wxz8 387 18 mg mg NN cord-283202-5fq1wxz8 387 19 / / SYM cord-283202-5fq1wxz8 387 20 kg kg NNP cord-283202-5fq1wxz8 388 1 PO PO NNP cord-283202-5fq1wxz8 388 2 q q NNP cord-283202-5fq1wxz8 388 3 12 12 CD cord-283202-5fq1wxz8 388 4 h. h. NN cord-283202-5fq1wxz8 388 5 116 116 CD cord-283202-5fq1wxz8 389 1 Reduced reduce VBN cord-283202-5fq1wxz8 389 2 hepatic hepatic JJ cord-283202-5fq1wxz8 389 3 metabolism metabolism NN cord-283202-5fq1wxz8 389 4 in in IN cord-283202-5fq1wxz8 389 5 animals animal NNS cord-283202-5fq1wxz8 389 6 with with IN cord-283202-5fq1wxz8 389 7 liver liver NN cord-283202-5fq1wxz8 389 8 disease disease NN cord-283202-5fq1wxz8 389 9 may may MD cord-283202-5fq1wxz8 389 10 result result VB cord-283202-5fq1wxz8 389 11 in in IN cord-283202-5fq1wxz8 389 12 an an DT cord-283202-5fq1wxz8 389 13 increased increase VBN cord-283202-5fq1wxz8 389 14 incidence incidence NN cord-283202-5fq1wxz8 389 15 of of IN cord-283202-5fq1wxz8 389 16 neurotoxicity neurotoxicity NN cord-283202-5fq1wxz8 389 17 . . . cord-283202-5fq1wxz8 390 1 142 142 CD cord-283202-5fq1wxz8 390 2 Alternatively alternatively RB cord-283202-5fq1wxz8 390 3 , , , cord-283202-5fq1wxz8 390 4 ampicillin ampicillin NN cord-283202-5fq1wxz8 390 5 or or CC cord-283202-5fq1wxz8 390 6 amoxicillin amoxicillin NNP cord-283202-5fq1wxz8 390 7 - - HYPH cord-283202-5fq1wxz8 390 8 clavulanate clavulanate NNP cord-283202-5fq1wxz8 390 9 can can MD cord-283202-5fq1wxz8 390 10 be be VB cord-283202-5fq1wxz8 390 11 administered administer VBN cord-283202-5fq1wxz8 390 12 . . . cord-283202-5fq1wxz8 391 1 In in IN cord-283202-5fq1wxz8 391 2 severely severely RB cord-283202-5fq1wxz8 391 3 affected affect VBN cord-283202-5fq1wxz8 391 4 animals animal NNS cord-283202-5fq1wxz8 391 5 , , , cord-283202-5fq1wxz8 391 6 antibiotics antibiotic NNS cord-283202-5fq1wxz8 391 7 ( ( -LRB- cord-283202-5fq1wxz8 391 8 ampicillin ampicillin NNP cord-283202-5fq1wxz8 391 9 , , , cord-283202-5fq1wxz8 391 10 amoxicillin amoxicillin NNP cord-283202-5fq1wxz8 391 11 or or CC cord-283202-5fq1wxz8 391 12 metronidazole metronidazole NNP cord-283202-5fq1wxz8 391 13 ) ) -RRB- cord-283202-5fq1wxz8 391 14 should should MD cord-283202-5fq1wxz8 391 15 be be VB cord-283202-5fq1wxz8 391 16 administered administer VBN cord-283202-5fq1wxz8 391 17 parenterally parenterally RB cord-283202-5fq1wxz8 391 18 . . . cord-283202-5fq1wxz8 392 1 There there EX cord-283202-5fq1wxz8 392 2 are be VBP cord-283202-5fq1wxz8 392 3 several several JJ cord-283202-5fq1wxz8 392 4 precipitating precipitate VBG cord-283202-5fq1wxz8 392 5 factors factor NNS cord-283202-5fq1wxz8 392 6 that that WDT cord-283202-5fq1wxz8 392 7 can can MD cord-283202-5fq1wxz8 392 8 lead lead VB cord-283202-5fq1wxz8 392 9 to to IN cord-283202-5fq1wxz8 392 10 HE HE NNP cord-283202-5fq1wxz8 392 11 , , , cord-283202-5fq1wxz8 392 12 and and CC cord-283202-5fq1wxz8 392 13 these these DT cord-283202-5fq1wxz8 392 14 should should MD cord-283202-5fq1wxz8 392 15 be be VB cord-283202-5fq1wxz8 392 16 identified identify VBN cord-283202-5fq1wxz8 392 17 and and CC cord-283202-5fq1wxz8 392 18 corrected correct VBN cord-283202-5fq1wxz8 392 19 in in IN cord-283202-5fq1wxz8 392 20 the the DT cord-283202-5fq1wxz8 392 21 individual individual JJ cord-283202-5fq1wxz8 392 22 animal animal NN cord-283202-5fq1wxz8 392 23 . . . cord-283202-5fq1wxz8 393 1 Correction correction NN cord-283202-5fq1wxz8 393 2 of of IN cord-283202-5fq1wxz8 393 3 dehydration dehydration NN cord-283202-5fq1wxz8 393 4 , , , cord-283202-5fq1wxz8 393 5 hypoglycemia hypoglycemia NN cord-283202-5fq1wxz8 393 6 and and CC cord-283202-5fq1wxz8 393 7 hypokalemia hypokalemia NN cord-283202-5fq1wxz8 393 8 is be VBZ cord-283202-5fq1wxz8 393 9 imperative imperative JJ cord-283202-5fq1wxz8 393 10 . . . cord-283202-5fq1wxz8 394 1 Animals animal NNS cord-283202-5fq1wxz8 394 2 with with IN cord-283202-5fq1wxz8 394 3 clinical clinical JJ cord-283202-5fq1wxz8 394 4 signs sign NNS cord-283202-5fq1wxz8 394 5 suggestive suggestive JJ cord-283202-5fq1wxz8 394 6 of of IN cord-283202-5fq1wxz8 394 7 gastrointestinal gastrointestinal JJ cord-283202-5fq1wxz8 394 8 bleeding bleeding NN cord-283202-5fq1wxz8 394 9 , , , cord-283202-5fq1wxz8 394 10 such such JJ cord-283202-5fq1wxz8 394 11 as as IN cord-283202-5fq1wxz8 394 12 melena melena NN cord-283202-5fq1wxz8 394 13 , , , cord-283202-5fq1wxz8 394 14 anorexia anorexia NN cord-283202-5fq1wxz8 394 15 and and CC cord-283202-5fq1wxz8 394 16 vomiting vomiting NN cord-283202-5fq1wxz8 394 17 , , , cord-283202-5fq1wxz8 394 18 should should MD cord-283202-5fq1wxz8 394 19 be be VB cord-283202-5fq1wxz8 394 20 treated treat VBN cord-283202-5fq1wxz8 394 21 with with IN cord-283202-5fq1wxz8 394 22 H H NNP cord-283202-5fq1wxz8 394 23 2 2 CD cord-283202-5fq1wxz8 394 24 -blockers -blocker NNS cord-283202-5fq1wxz8 394 25 . . . cord-283202-5fq1wxz8 395 1 In in IN cord-283202-5fq1wxz8 395 2 moderately moderately RB cord-283202-5fq1wxz8 395 3 to to IN cord-283202-5fq1wxz8 395 4 severely severely RB cord-283202-5fq1wxz8 395 5 affected affect VBN cord-283202-5fq1wxz8 395 6 animals animal NNS cord-283202-5fq1wxz8 395 7 , , , cord-283202-5fq1wxz8 395 8 food food NN cord-283202-5fq1wxz8 395 9 should should MD cord-283202-5fq1wxz8 395 10 be be VB cord-283202-5fq1wxz8 395 11 withheld withhold VBN cord-283202-5fq1wxz8 395 12 until until IN cord-283202-5fq1wxz8 395 13 therapy therapy NN cord-283202-5fq1wxz8 395 14 results result NNS cord-283202-5fq1wxz8 395 15 in in IN cord-283202-5fq1wxz8 395 16 significant significant JJ cord-283202-5fq1wxz8 395 17 improvements improvement NNS cord-283202-5fq1wxz8 395 18 . . . cord-283202-5fq1wxz8 396 1 Once once RB cord-283202-5fq1wxz8 396 2 a a DT cord-283202-5fq1wxz8 396 3 clinically clinically RB cord-283202-5fq1wxz8 396 4 significant significant JJ cord-283202-5fq1wxz8 396 5 improvement improvement NN cord-283202-5fq1wxz8 396 6 is be VBZ cord-283202-5fq1wxz8 396 7 obtained obtain VBN cord-283202-5fq1wxz8 396 8 , , , cord-283202-5fq1wxz8 396 9 affected affected JJ cord-283202-5fq1wxz8 396 10 animals animal NNS cord-283202-5fq1wxz8 396 11 should should MD cord-283202-5fq1wxz8 396 12 be be VB cord-283202-5fq1wxz8 396 13 fed feed VBN cord-283202-5fq1wxz8 396 14 a a DT cord-283202-5fq1wxz8 396 15 diet diet NN cord-283202-5fq1wxz8 396 16 restricted restrict VBN cord-283202-5fq1wxz8 396 17 in in IN cord-283202-5fq1wxz8 396 18 protein protein NN cord-283202-5fq1wxz8 396 19 , , , cord-283202-5fq1wxz8 396 20 with with IN cord-283202-5fq1wxz8 396 21 limited limited JJ cord-283202-5fq1wxz8 396 22 aromatic aromatic JJ cord-283202-5fq1wxz8 396 23 amino amino NN cord-283202-5fq1wxz8 396 24 acids acid NNS cord-283202-5fq1wxz8 396 25 and and CC cord-283202-5fq1wxz8 396 26 short short JJ cord-283202-5fq1wxz8 396 27 chain chain NN cord-283202-5fq1wxz8 396 28 fatty fatty JJ cord-283202-5fq1wxz8 396 29 acids acid NNS cord-283202-5fq1wxz8 396 30 . . . cord-283202-5fq1wxz8 397 1 114 114 CD cord-283202-5fq1wxz8 397 2 KEY KEY NNP cord-283202-5fq1wxz8 397 3 POINTS point NNS cord-283202-5fq1wxz8 397 4 : : : cord-283202-5fq1wxz8 398 1 HEPATIC HEPATIC NNP cord-283202-5fq1wxz8 398 2 ENCEPHALOPATHY ENCEPHALOPATHY NNS cord-283202-5fq1wxz8 398 3 placed place VBD cord-283202-5fq1wxz8 398 4 in in IN cord-283202-5fq1wxz8 398 5 a a DT cord-283202-5fq1wxz8 398 6 heparinized heparinize VBN cord-283202-5fq1wxz8 398 7 tube tube NN cord-283202-5fq1wxz8 398 8 and and CC cord-283202-5fq1wxz8 398 9 transferred transfer VBN cord-283202-5fq1wxz8 398 10 to to IN cord-283202-5fq1wxz8 398 11 the the DT cord-283202-5fq1wxz8 398 12 laboratory laboratory NN cord-283202-5fq1wxz8 398 13 on on IN cord-283202-5fq1wxz8 398 14 ice ice NN cord-283202-5fq1wxz8 398 15 for for IN cord-283202-5fq1wxz8 398 16 immediate immediate JJ cord-283202-5fq1wxz8 398 17 testing testing NN cord-283202-5fq1wxz8 398 18 . . . cord-283202-5fq1wxz8 399 1 Red red JJ cord-283202-5fq1wxz8 399 2 blood blood NN cord-283202-5fq1wxz8 399 3 cells cell NNS cord-283202-5fq1wxz8 399 4 contain contain VBP cord-283202-5fq1wxz8 399 5 large large JJ cord-283202-5fq1wxz8 399 6 amounts amount NNS cord-283202-5fq1wxz8 399 7 of of IN cord-283202-5fq1wxz8 399 8 ammonia ammonia NN cord-283202-5fq1wxz8 399 9 ; ; : cord-283202-5fq1wxz8 399 10 hence hence RB cord-283202-5fq1wxz8 399 11 hemolysis hemolysis NN cord-283202-5fq1wxz8 399 12 may may MD cord-283202-5fq1wxz8 399 13 result result VB cord-283202-5fq1wxz8 399 14 in in IN cord-283202-5fq1wxz8 399 15 falsely falsely RB cord-283202-5fq1wxz8 399 16 elevated elevated JJ cord-283202-5fq1wxz8 399 17 blood blood NN cord-283202-5fq1wxz8 399 18 ammonia ammonia NN cord-283202-5fq1wxz8 399 19 levels level NNS cord-283202-5fq1wxz8 399 20 . . . cord-283202-5fq1wxz8 400 1 Alternatively alternatively RB cord-283202-5fq1wxz8 400 2 , , , cord-283202-5fq1wxz8 400 3 a a DT cord-283202-5fq1wxz8 400 4 presumptive presumptive JJ cord-283202-5fq1wxz8 400 5 diagnosis diagnosis NN cord-283202-5fq1wxz8 400 6 of of IN cord-283202-5fq1wxz8 400 7 HE he PRP cord-283202-5fq1wxz8 400 8 can can MD cord-283202-5fq1wxz8 400 9 be be VB cord-283202-5fq1wxz8 400 10 made make VBN cord-283202-5fq1wxz8 400 11 by by IN cord-283202-5fq1wxz8 400 12 demonstrating demonstrate VBG cord-283202-5fq1wxz8 400 13 altered alter VBN cord-283202-5fq1wxz8 400 14 liver liver NN cord-283202-5fq1wxz8 400 15 function function NN cord-283202-5fq1wxz8 400 16 through through IN cord-283202-5fq1wxz8 400 17 fasting fast VBG cord-283202-5fq1wxz8 400 18 bile bile NN cord-283202-5fq1wxz8 400 19 acid acid NN cord-283202-5fq1wxz8 400 20 stimulation stimulation NN cord-283202-5fq1wxz8 400 21 testing testing NN cord-283202-5fq1wxz8 400 22 and and CC cord-283202-5fq1wxz8 400 23 on on IN cord-283202-5fq1wxz8 400 24 the the DT cord-283202-5fq1wxz8 400 25 basis basis NN cord-283202-5fq1wxz8 400 26 of of IN cord-283202-5fq1wxz8 400 27 response response NN cord-283202-5fq1wxz8 400 28 to to IN cord-283202-5fq1wxz8 400 29 therapy therapy NN cord-283202-5fq1wxz8 400 30 . . . cord-283202-5fq1wxz8 401 1 A a DT cord-283202-5fq1wxz8 401 2 suspected suspect VBN cord-283202-5fq1wxz8 401 3 or or CC cord-283202-5fq1wxz8 401 4 confirmed confirm VBN cord-283202-5fq1wxz8 401 5 diagnosis diagnosis NN cord-283202-5fq1wxz8 401 6 of of IN cord-283202-5fq1wxz8 401 7 HE he PRP cord-283202-5fq1wxz8 401 8 should should MD cord-283202-5fq1wxz8 401 9 prompt prompt VB cord-283202-5fq1wxz8 401 10 investigations investigation NNS cord-283202-5fq1wxz8 401 11 for for IN cord-283202-5fq1wxz8 401 12 congenital congenital JJ cord-283202-5fq1wxz8 401 13 or or CC cord-283202-5fq1wxz8 401 14 acquired acquire VBN cord-283202-5fq1wxz8 401 15 portosystemic portosystemic NN cord-283202-5fq1wxz8 401 16 shunting shunt VBG cord-283202-5fq1wxz8 401 17 . . . cord-283202-5fq1wxz8 402 1 Portosystemic portosystemic JJ cord-283202-5fq1wxz8 402 2 shunts shunt NNS cord-283202-5fq1wxz8 402 3 are be VBP cord-283202-5fq1wxz8 402 4 most most RBS cord-283202-5fq1wxz8 402 5 commonly commonly RB cord-283202-5fq1wxz8 402 6 diagnosed diagnose VBN cord-283202-5fq1wxz8 402 7 by by IN cord-283202-5fq1wxz8 402 8 ultrasonography ultrasonography NN cord-283202-5fq1wxz8 402 9 or or CC cord-283202-5fq1wxz8 402 10 per per IN cord-283202-5fq1wxz8 402 11 rectal rectal JJ cord-283202-5fq1wxz8 402 12 portal portal JJ cord-283202-5fq1wxz8 402 13 scintigraphy scintigraphy NN cord-283202-5fq1wxz8 402 14 using use VBG cord-283202-5fq1wxz8 402 15 99 99 CD cord-283202-5fq1wxz8 402 16 m m CD cord-283202-5fq1wxz8 402 17 technetium technetium NN cord-283202-5fq1wxz8 402 18 pertechnetate pertechnetate NN cord-283202-5fq1wxz8 402 19 . . . cord-283202-5fq1wxz8 403 1 [ [ -LRB- cord-283202-5fq1wxz8 403 2 136 136 CD cord-283202-5fq1wxz8 403 3 ] ] -RRB- cord-283202-5fq1wxz8 403 4 [ [ -LRB- cord-283202-5fq1wxz8 403 5 137 137 CD cord-283202-5fq1wxz8 403 6 ] ] -RRB- cord-283202-5fq1wxz8 404 1 [ [ -LRB- cord-283202-5fq1wxz8 404 2 138 138 CD cord-283202-5fq1wxz8 404 3 ] ] -RRB- cord-283202-5fq1wxz8 404 4 [ [ -LRB- cord-283202-5fq1wxz8 404 5 139 139 CD cord-283202-5fq1wxz8 404 6 ] ] -RRB- cord-283202-5fq1wxz8 405 1 Positive positive JJ cord-283202-5fq1wxz8 405 2 contrast contrast NN cord-283202-5fq1wxz8 405 3 portography portography NNP cord-283202-5fq1wxz8 405 4 also also RB cord-283202-5fq1wxz8 405 5 can can MD cord-283202-5fq1wxz8 405 6 be be VB cord-283202-5fq1wxz8 405 7 performed perform VBN cord-283202-5fq1wxz8 405 8 ; ; : cord-283202-5fq1wxz8 405 9 however however RB cord-283202-5fq1wxz8 405 10 , , , cord-283202-5fq1wxz8 405 11 this this DT cord-283202-5fq1wxz8 405 12 necessitates necessitate VBZ cord-283202-5fq1wxz8 405 13 general general JJ cord-283202-5fq1wxz8 405 14 anesthesia anesthesia NN cord-283202-5fq1wxz8 405 15 and and CC cord-283202-5fq1wxz8 405 16 laparotomy laparotomy NN cord-283202-5fq1wxz8 405 17 . . . cord-283202-5fq1wxz8 406 1 113 113 CD cord-283202-5fq1wxz8 407 1 The the DT cord-283202-5fq1wxz8 407 2 prognosis prognosis NN cord-283202-5fq1wxz8 407 3 for for IN cord-283202-5fq1wxz8 407 4 animals animal NNS cord-283202-5fq1wxz8 407 5 with with IN cord-283202-5fq1wxz8 407 6 HE he PRP cord-283202-5fq1wxz8 407 7 is be VBZ cord-283202-5fq1wxz8 407 8 dependent dependent JJ cord-283202-5fq1wxz8 407 9 on on IN cord-283202-5fq1wxz8 407 10 the the DT cord-283202-5fq1wxz8 407 11 underlying underlying JJ cord-283202-5fq1wxz8 407 12 liver liver NN cord-283202-5fq1wxz8 407 13 disease disease NN cord-283202-5fq1wxz8 407 14 . . . cord-283202-5fq1wxz8 408 1 With with IN cord-283202-5fq1wxz8 408 2 treatment treatment NN cord-283202-5fq1wxz8 408 3 , , , cord-283202-5fq1wxz8 408 4 most most JJS cord-283202-5fq1wxz8 408 5 animals animal NNS cord-283202-5fq1wxz8 408 6 experience experience VBP cord-283202-5fq1wxz8 408 7 an an DT cord-283202-5fq1wxz8 408 8 improvement improvement NN cord-283202-5fq1wxz8 408 9 in in IN cord-283202-5fq1wxz8 408 10 the the DT cord-283202-5fq1wxz8 408 11 clinical clinical JJ cord-283202-5fq1wxz8 408 12 signs sign NNS cord-283202-5fq1wxz8 408 13 related relate VBN cord-283202-5fq1wxz8 408 14 to to IN cord-283202-5fq1wxz8 408 15 HE he PRP cord-283202-5fq1wxz8 408 16 . . . cord-283202-5fq1wxz8 409 1 Severely severely RB cord-283202-5fq1wxz8 409 2 affected affect VBN cord-283202-5fq1wxz8 409 3 animals animal NNS cord-283202-5fq1wxz8 409 4 may may MD cord-283202-5fq1wxz8 409 5 not not RB cord-283202-5fq1wxz8 409 6 respond respond VB cord-283202-5fq1wxz8 409 7 to to IN cord-283202-5fq1wxz8 409 8 therapy therapy NN cord-283202-5fq1wxz8 409 9 , , , cord-283202-5fq1wxz8 409 10 however however RB cord-283202-5fq1wxz8 409 11 . . . cord-283202-5fq1wxz8 410 1 Animals animal NNS cord-283202-5fq1wxz8 410 2 with with IN cord-283202-5fq1wxz8 410 3 increased increase VBN cord-283202-5fq1wxz8 410 4 blood blood NN cord-283202-5fq1wxz8 410 5 ammonia ammonia NN cord-283202-5fq1wxz8 410 6 tend tend VBP cord-283202-5fq1wxz8 410 7 to to TO cord-283202-5fq1wxz8 410 8 respond respond VB cord-283202-5fq1wxz8 410 9 better better RB cord-283202-5fq1wxz8 410 10 to to IN cord-283202-5fq1wxz8 410 11 treatment treatment NN cord-283202-5fq1wxz8 410 12 than than IN cord-283202-5fq1wxz8 410 13 those those DT cord-283202-5fq1wxz8 410 14 with with IN cord-283202-5fq1wxz8 410 15 normal normal JJ cord-283202-5fq1wxz8 410 16 blood blood NN cord-283202-5fq1wxz8 410 17 ammonia ammonia NN cord-283202-5fq1wxz8 410 18 . . . cord-283202-5fq1wxz8 411 1 Feline feline JJ cord-283202-5fq1wxz8 411 2 infectious infectious JJ cord-283202-5fq1wxz8 411 3 peritonitis peritonitis NN cord-283202-5fq1wxz8 411 4 , , , cord-283202-5fq1wxz8 411 5 part part NN cord-283202-5fq1wxz8 411 6 2 2 CD cord-283202-5fq1wxz8 411 7 Feline feline JJ cord-283202-5fq1wxz8 411 8 infectious infectious JJ cord-283202-5fq1wxz8 411 9 peritonitis peritonitis NN cord-283202-5fq1wxz8 411 10 and and CC cord-283202-5fq1wxz8 411 11 feline feline JJ cord-283202-5fq1wxz8 411 12 enteric enteric JJ cord-283202-5fq1wxz8 411 13 coronavirus coronavirus NN cord-283202-5fq1wxz8 411 14 infections infection NNS cord-283202-5fq1wxz8 411 15 . . . cord-283202-5fq1wxz8 412 1 I. I. NNP cord-283202-5fq1wxz8 412 2 Feline feline JJ cord-283202-5fq1wxz8 412 3 enteric enteric JJ cord-283202-5fq1wxz8 412 4 coronaviruses coronaviruse NNS cord-283202-5fq1wxz8 413 1 Clinical clinical JJ cord-283202-5fq1wxz8 413 2 , , , cord-283202-5fq1wxz8 413 3 cerebrospinal cerebrospinal JJ cord-283202-5fq1wxz8 413 4 fluid fluid NN cord-283202-5fq1wxz8 413 5 , , , cord-283202-5fq1wxz8 413 6 and and CC cord-283202-5fq1wxz8 413 7 histological histological JJ cord-283202-5fq1wxz8 413 8 data datum NNS cord-283202-5fq1wxz8 413 9 from from IN cord-283202-5fq1wxz8 413 10 twenty twenty CD cord-283202-5fq1wxz8 413 11 - - HYPH cord-283202-5fq1wxz8 413 12 seven seven CD cord-283202-5fq1wxz8 413 13 cats cat NNS cord-283202-5fq1wxz8 413 14 with with IN cord-283202-5fq1wxz8 413 15 primary primary JJ cord-283202-5fq1wxz8 413 16 inflammatory inflammatory JJ cord-283202-5fq1wxz8 413 17 disease disease NN cord-283202-5fq1wxz8 413 18 of of IN cord-283202-5fq1wxz8 413 19 the the DT cord-283202-5fq1wxz8 413 20 central central JJ cord-283202-5fq1wxz8 413 21 nervous nervous JJ cord-283202-5fq1wxz8 413 22 system system NN cord-283202-5fq1wxz8 413 23 Inflammation inflammation NN cord-283202-5fq1wxz8 413 24 and and CC cord-283202-5fq1wxz8 413 25 changes change NNS cord-283202-5fq1wxz8 413 26 in in IN cord-283202-5fq1wxz8 413 27 cytokine cytokine NN cord-283202-5fq1wxz8 413 28 levels level NNS cord-283202-5fq1wxz8 413 29 in in IN cord-283202-5fq1wxz8 413 30 neurological neurological JJ cord-283202-5fq1wxz8 413 31 feline feline JJ cord-283202-5fq1wxz8 413 32 infectious infectious JJ cord-283202-5fq1wxz8 413 33 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 34 Use use NN cord-283202-5fq1wxz8 413 35 of of IN cord-283202-5fq1wxz8 413 36 anti anti JJ cord-283202-5fq1wxz8 413 37 - - JJ cord-283202-5fq1wxz8 413 38 coronavirus coronavirus JJ cord-283202-5fq1wxz8 413 39 antibody antibody NN cord-283202-5fq1wxz8 413 40 testing testing NN cord-283202-5fq1wxz8 413 41 of of IN cord-283202-5fq1wxz8 413 42 cerebrospinal cerebrospinal JJ cord-283202-5fq1wxz8 413 43 fluid fluid NN cord-283202-5fq1wxz8 413 44 for for IN cord-283202-5fq1wxz8 413 45 diagnosis diagnosis NN cord-283202-5fq1wxz8 413 46 of of IN cord-283202-5fq1wxz8 413 47 feline feline JJ cord-283202-5fq1wxz8 413 48 infectious infectious JJ cord-283202-5fq1wxz8 413 49 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 50 involving involve VBG cord-283202-5fq1wxz8 413 51 the the DT cord-283202-5fq1wxz8 413 52 central central JJ cord-283202-5fq1wxz8 413 53 nervous nervous JJ cord-283202-5fq1wxz8 413 54 system system NN cord-283202-5fq1wxz8 413 55 in in IN cord-283202-5fq1wxz8 413 56 cats cat NNS cord-283202-5fq1wxz8 413 57 Detection Detection NNP cord-283202-5fq1wxz8 413 58 of of IN cord-283202-5fq1wxz8 413 59 feline feline JJ cord-283202-5fq1wxz8 413 60 coronavirus coronavirus NN cord-283202-5fq1wxz8 413 61 RNA rna NN cord-283202-5fq1wxz8 413 62 in in IN cord-283202-5fq1wxz8 413 63 feces fece NNS cord-283202-5fq1wxz8 413 64 , , , cord-283202-5fq1wxz8 413 65 tissues tissue NNS cord-283202-5fq1wxz8 413 66 , , , cord-283202-5fq1wxz8 413 67 and and CC cord-283202-5fq1wxz8 413 68 body body NN cord-283202-5fq1wxz8 413 69 fluids fluid NNS cord-283202-5fq1wxz8 413 70 of of IN cord-283202-5fq1wxz8 413 71 naturally naturally RB cord-283202-5fq1wxz8 413 72 infected infect VBN cord-283202-5fq1wxz8 413 73 cats cat NNS cord-283202-5fq1wxz8 413 74 by by IN cord-283202-5fq1wxz8 413 75 reverse reverse JJ cord-283202-5fq1wxz8 413 76 transcriptase transcriptase NN cord-283202-5fq1wxz8 413 77 PCR PCR NNP cord-283202-5fq1wxz8 413 78 Detection Detection NNP cord-283202-5fq1wxz8 413 79 of of IN cord-283202-5fq1wxz8 413 80 feline feline JJ cord-283202-5fq1wxz8 413 81 coronaviruses coronaviruse NNS cord-283202-5fq1wxz8 413 82 by by IN cord-283202-5fq1wxz8 413 83 culture culture NN cord-283202-5fq1wxz8 413 84 and and CC cord-283202-5fq1wxz8 413 85 reverse reverse VB cord-283202-5fq1wxz8 413 86 transcriptase transcriptase NN cord-283202-5fq1wxz8 413 87 - - HYPH cord-283202-5fq1wxz8 413 88 polymerase polymerase NN cord-283202-5fq1wxz8 413 89 chain chain NN cord-283202-5fq1wxz8 413 90 reaction reaction NN cord-283202-5fq1wxz8 413 91 of of IN cord-283202-5fq1wxz8 413 92 blood blood NN cord-283202-5fq1wxz8 413 93 samples sample NNS cord-283202-5fq1wxz8 413 94 from from IN cord-283202-5fq1wxz8 413 95 healthy healthy JJ cord-283202-5fq1wxz8 413 96 cats cat NNS cord-283202-5fq1wxz8 413 97 and and CC cord-283202-5fq1wxz8 413 98 cats cat NNS cord-283202-5fq1wxz8 413 99 with with IN cord-283202-5fq1wxz8 413 100 clinical clinical JJ cord-283202-5fq1wxz8 413 101 feline feline JJ cord-283202-5fq1wxz8 413 102 infectious infectious JJ cord-283202-5fq1wxz8 413 103 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 104 Development Development NNP cord-283202-5fq1wxz8 413 105 of of IN cord-283202-5fq1wxz8 413 106 a a DT cord-283202-5fq1wxz8 413 107 nested nest VBN cord-283202-5fq1wxz8 413 108 PCR PCR NNP cord-283202-5fq1wxz8 413 109 assay assay NN cord-283202-5fq1wxz8 413 110 for for IN cord-283202-5fq1wxz8 413 111 detection detection NN cord-283202-5fq1wxz8 413 112 of of IN cord-283202-5fq1wxz8 413 113 feline feline JJ cord-283202-5fq1wxz8 413 114 infectious infectious JJ cord-283202-5fq1wxz8 413 115 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 116 virus virus NN cord-283202-5fq1wxz8 413 117 in in IN cord-283202-5fq1wxz8 413 118 clinical clinical JJ cord-283202-5fq1wxz8 413 119 specimens specimen NNS cord-283202-5fq1wxz8 413 120 Critical critical JJ cord-283202-5fq1wxz8 413 121 assessment assessment NN cord-283202-5fq1wxz8 413 122 of of IN cord-283202-5fq1wxz8 413 123 the the DT cord-283202-5fq1wxz8 413 124 diagnostic diagnostic JJ cord-283202-5fq1wxz8 413 125 value value NN cord-283202-5fq1wxz8 413 126 of of IN cord-283202-5fq1wxz8 413 127 feline feline JJ cord-283202-5fq1wxz8 413 128 alpha1-acid alpha1-acid JJ cord-283202-5fq1wxz8 413 129 glycoprotein glycoprotein NN cord-283202-5fq1wxz8 413 130 for for IN cord-283202-5fq1wxz8 413 131 feline feline JJ cord-283202-5fq1wxz8 413 132 infectious infectious JJ cord-283202-5fq1wxz8 413 133 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 134 using use VBG cord-283202-5fq1wxz8 413 135 the the DT cord-283202-5fq1wxz8 413 136 likelihood likelihood NN cord-283202-5fq1wxz8 413 137 ratios ratio NNS cord-283202-5fq1wxz8 413 138 approach approach VBP cord-283202-5fq1wxz8 413 139 Value Value NNP cord-283202-5fq1wxz8 413 140 of of IN cord-283202-5fq1wxz8 413 141 agr1-acid agr1-acid NNP cord-283202-5fq1wxz8 413 142 glycoprotein glycoprotein NN cord-283202-5fq1wxz8 413 143 in in IN cord-283202-5fq1wxz8 413 144 the the DT cord-283202-5fq1wxz8 413 145 diagnosis diagnosis NN cord-283202-5fq1wxz8 413 146 of of IN cord-283202-5fq1wxz8 413 147 feline feline JJ cord-283202-5fq1wxz8 413 148 infectious infectious JJ cord-283202-5fq1wxz8 413 149 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 150 Serum serum NN cord-283202-5fq1wxz8 413 151 [ [ -LRB- cord-283202-5fq1wxz8 413 152 alpha]1-acid alpha]1-acid NN cord-283202-5fq1wxz8 413 153 glycoprotein glycoprotein NN cord-283202-5fq1wxz8 413 154 ( ( -LRB- cord-283202-5fq1wxz8 413 155 AGP AGP NNP cord-283202-5fq1wxz8 413 156 ) ) -RRB- cord-283202-5fq1wxz8 413 157 concentration concentration NN cord-283202-5fq1wxz8 413 158 in in IN cord-283202-5fq1wxz8 413 159 non non JJ cord-283202-5fq1wxz8 413 160 - - JJ cord-283202-5fq1wxz8 413 161 symptomatic symptomatic JJ cord-283202-5fq1wxz8 413 162 cats cat NNS cord-283202-5fq1wxz8 413 163 with with IN cord-283202-5fq1wxz8 413 164 feline feline JJ cord-283202-5fq1wxz8 413 165 coronavirus coronavirus NN cord-283202-5fq1wxz8 413 166 ( ( -LRB- cord-283202-5fq1wxz8 413 167 FCoV FCoV NNP cord-283202-5fq1wxz8 413 168 ) ) -RRB- cord-283202-5fq1wxz8 413 169 infection infection NN cord-283202-5fq1wxz8 413 170 Treatment treatment NN cord-283202-5fq1wxz8 413 171 of of IN cord-283202-5fq1wxz8 413 172 cats cat NNS cord-283202-5fq1wxz8 413 173 with with IN cord-283202-5fq1wxz8 413 174 feline feline JJ cord-283202-5fq1wxz8 413 175 infectious infectious JJ cord-283202-5fq1wxz8 413 176 peritonitis peritonitis NN cord-283202-5fq1wxz8 413 177 Diagnosis diagnosis NN cord-283202-5fq1wxz8 413 178 of of IN cord-283202-5fq1wxz8 413 179 induced induce VBN cord-283202-5fq1wxz8 413 180 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 413 181 in in IN cord-283202-5fq1wxz8 413 182 neonatal neonatal JJ cord-283202-5fq1wxz8 413 183 cats cat NNS cord-283202-5fq1wxz8 413 184 Toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 413 185 in in IN cord-283202-5fq1wxz8 413 186 cats cat NNS cord-283202-5fq1wxz8 413 187 Infectious infectious JJ cord-283202-5fq1wxz8 413 188 diseases disease NNS cord-283202-5fq1wxz8 413 189 of of IN cord-283202-5fq1wxz8 413 190 the the DT cord-283202-5fq1wxz8 413 191 dog dog NN cord-283202-5fq1wxz8 413 192 and and CC cord-283202-5fq1wxz8 413 193 cat cat VB cord-283202-5fq1wxz8 413 194 Feline feline JJ cord-283202-5fq1wxz8 413 195 immunodeficiency immunodeficiency NN cord-283202-5fq1wxz8 413 196 virus virus NN cord-283202-5fq1wxz8 413 197 predisposes predispose VBZ cord-283202-5fq1wxz8 413 198 cats cat NNS cord-283202-5fq1wxz8 413 199 to to TO cord-283202-5fq1wxz8 413 200 acute acute JJ cord-283202-5fq1wxz8 413 201 generalized generalized JJ cord-283202-5fq1wxz8 413 202 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 413 203 Clinical clinical JJ cord-283202-5fq1wxz8 413 204 and and CC cord-283202-5fq1wxz8 413 205 epidemiological epidemiological JJ cord-283202-5fq1wxz8 413 206 aspects aspect NNS cord-283202-5fq1wxz8 413 207 of of IN cord-283202-5fq1wxz8 413 208 feline feline JJ cord-283202-5fq1wxz8 413 209 immunodeficiency immunodeficiency NN cord-283202-5fq1wxz8 413 210 virus virus NN cord-283202-5fq1wxz8 413 211 and and CC cord-283202-5fq1wxz8 413 212 Toxoplasma Toxoplasma NNP cord-283202-5fq1wxz8 413 213 gondii gondii NN cord-283202-5fq1wxz8 413 214 coinfections coinfection NNS cord-283202-5fq1wxz8 413 215 in in IN cord-283202-5fq1wxz8 413 216 cats cat NNS cord-283202-5fq1wxz8 413 217 Clinical clinical JJ cord-283202-5fq1wxz8 413 218 feline feline JJ cord-283202-5fq1wxz8 413 219 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 413 220 : : : cord-283202-5fq1wxz8 413 221 serological serological JJ cord-283202-5fq1wxz8 413 222 diagnosis diagnosis NN cord-283202-5fq1wxz8 413 223 and and CC cord-283202-5fq1wxz8 413 224 therapeutic therapeutic JJ cord-283202-5fq1wxz8 413 225 management management NN cord-283202-5fq1wxz8 413 226 of of IN cord-283202-5fq1wxz8 413 227 15 15 CD cord-283202-5fq1wxz8 413 228 cases case NNS cord-283202-5fq1wxz8 413 229 Prevalence prevalence NN cord-283202-5fq1wxz8 413 230 of of IN cord-283202-5fq1wxz8 413 231 Toxoplasma toxoplasma JJ cord-283202-5fq1wxz8 413 232 gondii gondii NN cord-283202-5fq1wxz8 413 233 infection infection NN cord-283202-5fq1wxz8 413 234 in in IN cord-283202-5fq1wxz8 413 235 cats cat NNS cord-283202-5fq1wxz8 413 236 in in IN cord-283202-5fq1wxz8 413 237 Georgia Georgia NNP cord-283202-5fq1wxz8 413 238 using use VBG cord-283202-5fq1wxz8 413 239 enzyme enzyme NN cord-283202-5fq1wxz8 413 240 - - HYPH cord-283202-5fq1wxz8 413 241 linked link VBN cord-283202-5fq1wxz8 413 242 immunosorbent immunosorbent JJ cord-283202-5fq1wxz8 413 243 assays assay NNS cord-283202-5fq1wxz8 413 244 for for IN cord-283202-5fq1wxz8 413 245 IgM IgM NNP cord-283202-5fq1wxz8 413 246 , , , cord-283202-5fq1wxz8 413 247 IgG IgG NNP cord-283202-5fq1wxz8 413 248 , , , cord-283202-5fq1wxz8 413 249 and and CC cord-283202-5fq1wxz8 413 250 antigens antigen VBD cord-283202-5fq1wxz8 413 251 Antemortem Antemortem NNP cord-283202-5fq1wxz8 413 252 diagnosis diagnosis NN cord-283202-5fq1wxz8 413 253 and and CC cord-283202-5fq1wxz8 413 254 treatment treatment NN cord-283202-5fq1wxz8 413 255 of of IN cord-283202-5fq1wxz8 413 256 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 413 257 in in IN cord-283202-5fq1wxz8 413 258 two two CD cord-283202-5fq1wxz8 413 259 cats cat NNS cord-283202-5fq1wxz8 413 260 on on IN cord-283202-5fq1wxz8 413 261 cyclosporin cyclosporin NN cord-283202-5fq1wxz8 413 262 therapy therapy NN cord-283202-5fq1wxz8 413 263 A a DT cord-283202-5fq1wxz8 413 264 case case NN cord-283202-5fq1wxz8 413 265 of of IN cord-283202-5fq1wxz8 413 266 fatal fatal JJ cord-283202-5fq1wxz8 413 267 systemic systemic JJ cord-283202-5fq1wxz8 413 268 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 413 269 in in IN cord-283202-5fq1wxz8 413 270 a a DT cord-283202-5fq1wxz8 413 271 cat cat NN cord-283202-5fq1wxz8 413 272 being be VBG cord-283202-5fq1wxz8 413 273 treated treat VBN cord-283202-5fq1wxz8 413 274 with with IN cord-283202-5fq1wxz8 413 275 cyclosporin cyclosporin NN cord-283202-5fq1wxz8 413 276 A a NN cord-283202-5fq1wxz8 413 277 for for IN cord-283202-5fq1wxz8 413 278 feline feline JJ cord-283202-5fq1wxz8 413 279 atopy atopy NN cord-283202-5fq1wxz8 413 280 BSAVA BSAVA NNP cord-283202-5fq1wxz8 413 281 manual manual NN cord-283202-5fq1wxz8 413 282 of of IN cord-283202-5fq1wxz8 413 283 canine canine JJ cord-283202-5fq1wxz8 413 284 and and CC cord-283202-5fq1wxz8 413 285 feline feline JJ cord-283202-5fq1wxz8 413 286 neurology neurology NN cord-283202-5fq1wxz8 413 287 Neurological neurological JJ cord-283202-5fq1wxz8 413 288 history history NN cord-283202-5fq1wxz8 413 289 and and CC cord-283202-5fq1wxz8 413 290 examination examination NN cord-283202-5fq1wxz8 413 291 . . . cord-283202-5fq1wxz8 414 1 In in IN cord-283202-5fq1wxz8 414 2 : : : cord-283202-5fq1wxz8 414 3 Handbook Handbook NNP cord-283202-5fq1wxz8 414 4 of of IN cord-283202-5fq1wxz8 414 5 veterinary veterinary JJ cord-283202-5fq1wxz8 414 6 neurology neurology NN cord-283202-5fq1wxz8 414 7 Feline feline JJ cord-283202-5fq1wxz8 414 8 infectious infectious JJ cord-283202-5fq1wxz8 414 9 peritonitis peritonitis NN cord-283202-5fq1wxz8 415 1 Some some DT cord-283202-5fq1wxz8 415 2 important important JJ cord-283202-5fq1wxz8 415 3 disorders disorder NNS cord-283202-5fq1wxz8 415 4 of of IN cord-283202-5fq1wxz8 415 5 cats cat NNS cord-283202-5fq1wxz8 415 6 Feline feline JJ cord-283202-5fq1wxz8 415 7 infectious infectious JJ cord-283202-5fq1wxz8 415 8 peritonitis peritonitis NN cord-283202-5fq1wxz8 415 9 : : : cord-283202-5fq1wxz8 415 10 isolation isolation NN cord-283202-5fq1wxz8 415 11 of of IN cord-283202-5fq1wxz8 415 12 a a DT cord-283202-5fq1wxz8 415 13 coronavirus coronavirus NN cord-283202-5fq1wxz8 415 14 Feline feline JJ cord-283202-5fq1wxz8 415 15 infectious infectious JJ cord-283202-5fq1wxz8 415 16 peritonitis peritonitis NN cord-283202-5fq1wxz8 415 17 viruses virus NNS cord-283202-5fq1wxz8 415 18 arise arise VBP cord-283202-5fq1wxz8 415 19 by by IN cord-283202-5fq1wxz8 415 20 mutation mutation NN cord-283202-5fq1wxz8 415 21 from from IN cord-283202-5fq1wxz8 415 22 endemic endemic JJ cord-283202-5fq1wxz8 415 23 feline feline JJ cord-283202-5fq1wxz8 415 24 enteric enteric JJ cord-283202-5fq1wxz8 415 25 coronaviruses coronaviruse NNS cord-283202-5fq1wxz8 416 1 Seroprevalence Seroprevalence NNP cord-283202-5fq1wxz8 416 2 study study NN cord-283202-5fq1wxz8 416 3 of of IN cord-283202-5fq1wxz8 416 4 feline feline JJ cord-283202-5fq1wxz8 416 5 coronavirus coronavirus NN cord-283202-5fq1wxz8 416 6 in in IN cord-283202-5fq1wxz8 416 7 owned own VBN cord-283202-5fq1wxz8 416 8 and and CC cord-283202-5fq1wxz8 416 9 feral feral JJ cord-283202-5fq1wxz8 416 10 cats cat NNS cord-283202-5fq1wxz8 416 11 in in IN cord-283202-5fq1wxz8 416 12 Sydney Sydney NNP cord-283202-5fq1wxz8 416 13 Feline feline JJ cord-283202-5fq1wxz8 416 14 coronavirus coronavirus NN cord-283202-5fq1wxz8 416 15 antibodies antibody NNS cord-283202-5fq1wxz8 416 16 in in IN cord-283202-5fq1wxz8 416 17 UK UK NNP cord-283202-5fq1wxz8 416 18 cats cat NNS cord-283202-5fq1wxz8 416 19 Comparison Comparison NNP cord-283202-5fq1wxz8 416 20 of of IN cord-283202-5fq1wxz8 416 21 serologic serologic JJ cord-283202-5fq1wxz8 416 22 techniques technique NNS cord-283202-5fq1wxz8 416 23 for for IN cord-283202-5fq1wxz8 416 24 the the DT cord-283202-5fq1wxz8 416 25 detection detection NN cord-283202-5fq1wxz8 416 26 of of IN cord-283202-5fq1wxz8 416 27 antibodies antibody NNS cord-283202-5fq1wxz8 416 28 against against IN cord-283202-5fq1wxz8 416 29 feline feline JJ cord-283202-5fq1wxz8 416 30 coronaviruses coronaviruse NNS cord-283202-5fq1wxz8 416 31 Feline feline JJ cord-283202-5fq1wxz8 416 32 coronavirus coronavirus NN cord-283202-5fq1wxz8 416 33 serotypes serotypes NN cord-283202-5fq1wxz8 416 34 1 1 CD cord-283202-5fq1wxz8 416 35 and and CC cord-283202-5fq1wxz8 416 36 2 2 CD cord-283202-5fq1wxz8 416 37 : : : cord-283202-5fq1wxz8 416 38 seroprevalence seroprevalence NN cord-283202-5fq1wxz8 416 39 and and CC cord-283202-5fq1wxz8 416 40 association association NN cord-283202-5fq1wxz8 416 41 with with IN cord-283202-5fq1wxz8 416 42 disease disease NN cord-283202-5fq1wxz8 416 43 in in IN cord-283202-5fq1wxz8 416 44 Switzerland Switzerland NNP cord-283202-5fq1wxz8 416 45 Feline feline JJ cord-283202-5fq1wxz8 416 46 coronavirus coronavirus NN cord-283202-5fq1wxz8 416 47 antibodies antibody NNS cord-283202-5fq1wxz8 416 48 in in IN cord-283202-5fq1wxz8 416 49 cats cat NNS cord-283202-5fq1wxz8 416 50 Serologic Serologic NNP cord-283202-5fq1wxz8 416 51 studies study NNS cord-283202-5fq1wxz8 416 52 of of IN cord-283202-5fq1wxz8 416 53 naturally naturally RB cord-283202-5fq1wxz8 416 54 occurring occur VBG cord-283202-5fq1wxz8 416 55 feline feline JJ cord-283202-5fq1wxz8 416 56 infectious infectious JJ cord-283202-5fq1wxz8 416 57 peritonitis peritonitis NN cord-283202-5fq1wxz8 416 58 Prevalence prevalence NN cord-283202-5fq1wxz8 416 59 of of IN cord-283202-5fq1wxz8 416 60 feline feline JJ cord-283202-5fq1wxz8 416 61 infectious infectious JJ cord-283202-5fq1wxz8 416 62 peritonitis peritonitis NN cord-283202-5fq1wxz8 416 63 in in IN cord-283202-5fq1wxz8 416 64 specific specific JJ cord-283202-5fq1wxz8 416 65 cat cat NN cord-283202-5fq1wxz8 416 66 breeds breed VBZ cord-283202-5fq1wxz8 416 67 Patterns pattern NNS cord-283202-5fq1wxz8 416 68 of of IN cord-283202-5fq1wxz8 416 69 feline feline JJ cord-283202-5fq1wxz8 416 70 coronavirus coronavirus NN cord-283202-5fq1wxz8 416 71 infection infection NN cord-283202-5fq1wxz8 416 72 and and CC cord-283202-5fq1wxz8 416 73 fecal fecal JJ cord-283202-5fq1wxz8 416 74 shedding shedding NN cord-283202-5fq1wxz8 416 75 from from IN cord-283202-5fq1wxz8 416 76 cats cat NNS cord-283202-5fq1wxz8 416 77 in in IN cord-283202-5fq1wxz8 416 78 multiple multiple JJ cord-283202-5fq1wxz8 416 79 - - HYPH cord-283202-5fq1wxz8 416 80 cat cat NN cord-283202-5fq1wxz8 416 81 environments environment NNS cord-283202-5fq1wxz8 416 82 Risk risk NN cord-283202-5fq1wxz8 416 83 factors factor NNS cord-283202-5fq1wxz8 416 84 for for IN cord-283202-5fq1wxz8 416 85 feline feline JJ cord-283202-5fq1wxz8 416 86 infectious infectious JJ cord-283202-5fq1wxz8 416 87 peritonitis peritonitis NN cord-283202-5fq1wxz8 416 88 among among IN cord-283202-5fq1wxz8 416 89 cats cat NNS cord-283202-5fq1wxz8 416 90 in in IN cord-283202-5fq1wxz8 416 91 multiple multiple JJ cord-283202-5fq1wxz8 416 92 - - HYPH cord-283202-5fq1wxz8 416 93 cat cat NN cord-283202-5fq1wxz8 416 94 environments environment NNS cord-283202-5fq1wxz8 416 95 with with IN cord-283202-5fq1wxz8 416 96 endemic endemic JJ cord-283202-5fq1wxz8 416 97 feline feline JJ cord-283202-5fq1wxz8 416 98 enteric enteric JJ cord-283202-5fq1wxz8 416 99 coronavirus coronavirus NN cord-283202-5fq1wxz8 417 1 An an DT cord-283202-5fq1wxz8 417 2 overview overview NN cord-283202-5fq1wxz8 417 3 of of IN cord-283202-5fq1wxz8 417 4 feline feline JJ cord-283202-5fq1wxz8 417 5 enteric enteric JJ cord-283202-5fq1wxz8 417 6 coronavirus coronavirus NN cord-283202-5fq1wxz8 417 7 and and CC cord-283202-5fq1wxz8 417 8 infectious infectious JJ cord-283202-5fq1wxz8 417 9 peritonitis peritonitis NN cord-283202-5fq1wxz8 417 10 virus virus NN cord-283202-5fq1wxz8 417 11 infections infection NNS cord-283202-5fq1wxz8 417 12 Topics topic NNS cord-283202-5fq1wxz8 417 13 in in IN cord-283202-5fq1wxz8 417 14 feline feline JJ cord-283202-5fq1wxz8 417 15 neurology neurology NN cord-283202-5fq1wxz8 417 16 Diagnostic Diagnostic NNP cord-283202-5fq1wxz8 417 17 features feature NNS cord-283202-5fq1wxz8 417 18 of of IN cord-283202-5fq1wxz8 417 19 clinical clinical JJ cord-283202-5fq1wxz8 417 20 neurologic neurologic JJ cord-283202-5fq1wxz8 417 21 feline feline JJ cord-283202-5fq1wxz8 417 22 infectious infectious JJ cord-283202-5fq1wxz8 417 23 peritonitis peritonitis NN cord-283202-5fq1wxz8 417 24 A a DT cord-283202-5fq1wxz8 417 25 review review NN cord-283202-5fq1wxz8 417 26 of of IN cord-283202-5fq1wxz8 417 27 coronavirus coronavirus NN cord-283202-5fq1wxz8 417 28 infection infection NN cord-283202-5fq1wxz8 417 29 in in IN cord-283202-5fq1wxz8 417 30 the the DT cord-283202-5fq1wxz8 417 31 central central JJ cord-283202-5fq1wxz8 417 32 nervous nervous JJ cord-283202-5fq1wxz8 417 33 system system NN cord-283202-5fq1wxz8 417 34 of of IN cord-283202-5fq1wxz8 417 35 cats cat NNS cord-283202-5fq1wxz8 417 36 and and CC cord-283202-5fq1wxz8 417 37 mice mouse NNS cord-283202-5fq1wxz8 417 38 Feline feline JJ cord-283202-5fq1wxz8 417 39 infectious infectious JJ cord-283202-5fq1wxz8 417 40 peritonitis peritonitis NN cord-283202-5fq1wxz8 417 41 with with IN cord-283202-5fq1wxz8 417 42 neurologic neurologic JJ cord-283202-5fq1wxz8 417 43 involvement involvement NN cord-283202-5fq1wxz8 417 44 : : : cord-283202-5fq1wxz8 417 45 clinical clinical JJ cord-283202-5fq1wxz8 417 46 and and CC cord-283202-5fq1wxz8 417 47 pathological pathological JJ cord-283202-5fq1wxz8 417 48 findings finding NNS cord-283202-5fq1wxz8 417 49 in in IN cord-283202-5fq1wxz8 417 50 24 24 CD cord-283202-5fq1wxz8 417 51 cats cat NNS cord-283202-5fq1wxz8 417 52 Results result NNS cord-283202-5fq1wxz8 417 53 of of IN cord-283202-5fq1wxz8 417 54 magnetic magnetic JJ cord-283202-5fq1wxz8 417 55 resonance resonance NN cord-283202-5fq1wxz8 417 56 imaging imaging NN cord-283202-5fq1wxz8 417 57 in in IN cord-283202-5fq1wxz8 417 58 14 14 CD cord-283202-5fq1wxz8 417 59 cats cat NNS cord-283202-5fq1wxz8 417 60 with with IN cord-283202-5fq1wxz8 417 61 meningoencephalitis meningoencephalitis NNP cord-283202-5fq1wxz8 417 62 Laboratory Laboratory NNP cord-283202-5fq1wxz8 417 63 profiles profile NNS cord-283202-5fq1wxz8 417 64 in in IN cord-283202-5fq1wxz8 417 65 cats cat NNS cord-283202-5fq1wxz8 417 66 with with IN cord-283202-5fq1wxz8 417 67 different different JJ cord-283202-5fq1wxz8 417 68 pathological pathological JJ cord-283202-5fq1wxz8 417 69 and and CC cord-283202-5fq1wxz8 417 70 immunohistochemical immunohistochemical JJ cord-283202-5fq1wxz8 417 71 findings finding NNS cord-283202-5fq1wxz8 417 72 due due JJ cord-283202-5fq1wxz8 417 73 to to IN cord-283202-5fq1wxz8 417 74 feline feline JJ cord-283202-5fq1wxz8 417 75 infectious infectious JJ cord-283202-5fq1wxz8 417 76 peritonitis peritonitis NN cord-283202-5fq1wxz8 417 77 ( ( -LRB- cord-283202-5fq1wxz8 417 78 FIP fip NN cord-283202-5fq1wxz8 417 79 ) ) -RRB- cord-283202-5fq1wxz8 418 1 An an DT cord-283202-5fq1wxz8 418 2 appraisal appraisal NN cord-283202-5fq1wxz8 418 3 of of IN cord-283202-5fq1wxz8 418 4 the the DT cord-283202-5fq1wxz8 418 5 value value NN cord-283202-5fq1wxz8 418 6 of of IN cord-283202-5fq1wxz8 418 7 laboratory laboratory NN cord-283202-5fq1wxz8 418 8 tests test NNS cord-283202-5fq1wxz8 418 9 in in IN cord-283202-5fq1wxz8 418 10 the the DT cord-283202-5fq1wxz8 418 11 diagnosis diagnosis NN cord-283202-5fq1wxz8 418 12 of of IN cord-283202-5fq1wxz8 418 13 feline feline JJ cord-283202-5fq1wxz8 418 14 infectious infectious JJ cord-283202-5fq1wxz8 418 15 peritonitis peritonitis NN cord-283202-5fq1wxz8 418 16 Feline feline JJ cord-283202-5fq1wxz8 418 17 infectious infectious JJ cord-283202-5fq1wxz8 418 18 peritonitis peritonitis NN cord-283202-5fq1wxz8 418 19 in in IN cord-283202-5fq1wxz8 418 20 a a DT cord-283202-5fq1wxz8 418 21 closed closed JJ cord-283202-5fq1wxz8 418 22 breeding breeding NN cord-283202-5fq1wxz8 418 23 colony colony NN cord-283202-5fq1wxz8 418 24 Acute acute JJ cord-283202-5fq1wxz8 418 25 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 418 26 following follow VBG cord-283202-5fq1wxz8 418 27 renal renal JJ cord-283202-5fq1wxz8 418 28 transplantation transplantation NN cord-283202-5fq1wxz8 418 29 in in IN cord-283202-5fq1wxz8 418 30 three three CD cord-283202-5fq1wxz8 418 31 cats cat NNS cord-283202-5fq1wxz8 418 32 and and CC cord-283202-5fq1wxz8 418 33 a a DT cord-283202-5fq1wxz8 418 34 dog dog NN cord-283202-5fq1wxz8 418 35 Diagnostic diagnostic JJ cord-283202-5fq1wxz8 418 36 predictors predictor NNS cord-283202-5fq1wxz8 418 37 of of IN cord-283202-5fq1wxz8 418 38 complications complication NNS cord-283202-5fq1wxz8 418 39 and and CC cord-283202-5fq1wxz8 418 40 survival survival NN cord-283202-5fq1wxz8 418 41 after after IN cord-283202-5fq1wxz8 418 42 renal renal JJ cord-283202-5fq1wxz8 418 43 transplantation transplantation NN cord-283202-5fq1wxz8 418 44 in in IN cord-283202-5fq1wxz8 418 45 cats cat NNS cord-283202-5fq1wxz8 418 46 Evaluation Evaluation NNP cord-283202-5fq1wxz8 418 47 of of IN cord-283202-5fq1wxz8 418 48 the the DT cord-283202-5fq1wxz8 418 49 prevalence prevalence NN cord-283202-5fq1wxz8 418 50 of of IN cord-283202-5fq1wxz8 418 51 infections infection NNS cord-283202-5fq1wxz8 418 52 in in IN cord-283202-5fq1wxz8 418 53 cats cat NNS cord-283202-5fq1wxz8 418 54 after after IN cord-283202-5fq1wxz8 418 55 renal renal JJ cord-283202-5fq1wxz8 418 56 transplantation transplantation NN cord-283202-5fq1wxz8 418 57 : : : cord-283202-5fq1wxz8 418 58 169 169 CD cord-283202-5fq1wxz8 418 59 cases case NNS cord-283202-5fq1wxz8 418 60 Histologically Histologically NNP cord-283202-5fq1wxz8 418 61 confirmed confirm VBD cord-283202-5fq1wxz8 418 62 clinical clinical JJ cord-283202-5fq1wxz8 418 63 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 418 64 in in IN cord-283202-5fq1wxz8 418 65 cats cat NNS cord-283202-5fq1wxz8 418 66 : : : cord-283202-5fq1wxz8 418 67 100 100 CD cord-283202-5fq1wxz8 418 68 cases case NNS cord-283202-5fq1wxz8 418 69 ( ( -LRB- cord-283202-5fq1wxz8 418 70 1952 1952 CD cord-283202-5fq1wxz8 418 71 - - SYM cord-283202-5fq1wxz8 418 72 1990 1990 CD cord-283202-5fq1wxz8 418 73 ) ) -RRB- cord-283202-5fq1wxz8 419 1 Toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 419 2 in in IN cord-283202-5fq1wxz8 419 3 the the DT cord-283202-5fq1wxz8 419 4 cat cat NN cord-283202-5fq1wxz8 419 5 ; ; : cord-283202-5fq1wxz8 419 6 fourteen fourteen CD cord-283202-5fq1wxz8 419 7 cases case NNS cord-283202-5fq1wxz8 419 8 Fatal fatal JJ cord-283202-5fq1wxz8 419 9 neonatal neonatal JJ cord-283202-5fq1wxz8 419 10 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 419 11 in in IN cord-283202-5fq1wxz8 419 12 cats cat NNS cord-283202-5fq1wxz8 419 13 Lesions lesion NNS cord-283202-5fq1wxz8 419 14 of of IN cord-283202-5fq1wxz8 419 15 neonatally neonatally RB cord-283202-5fq1wxz8 419 16 induced induce VBN cord-283202-5fq1wxz8 419 17 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 419 18 in in IN cord-283202-5fq1wxz8 419 19 cats cat NNS cord-283202-5fq1wxz8 419 20 Suspected suspect VBD cord-283202-5fq1wxz8 419 21 toxoplasma toxoplasma NN cord-283202-5fq1wxz8 419 22 - - HYPH cord-283202-5fq1wxz8 419 23 associated associate VBN cord-283202-5fq1wxz8 419 24 myocarditis myocarditis NN cord-283202-5fq1wxz8 419 25 in in IN cord-283202-5fq1wxz8 419 26 a a DT cord-283202-5fq1wxz8 419 27 cat cat NN cord-283202-5fq1wxz8 419 28 Clinical clinical JJ cord-283202-5fq1wxz8 419 29 and and CC cord-283202-5fq1wxz8 419 30 magnetic magnetic JJ cord-283202-5fq1wxz8 419 31 resonance resonance NN cord-283202-5fq1wxz8 419 32 imaging imaging NN cord-283202-5fq1wxz8 419 33 findings finding NNS cord-283202-5fq1wxz8 419 34 in in IN cord-283202-5fq1wxz8 419 35 92 92 CD cord-283202-5fq1wxz8 419 36 cats cat NNS cord-283202-5fq1wxz8 419 37 with with IN cord-283202-5fq1wxz8 419 38 clinical clinical JJ cord-283202-5fq1wxz8 419 39 signs sign NNS cord-283202-5fq1wxz8 419 40 of of IN cord-283202-5fq1wxz8 419 41 spinal spinal JJ cord-283202-5fq1wxz8 419 42 cord cord NN cord-283202-5fq1wxz8 419 43 disease disease NN cord-283202-5fq1wxz8 419 44 Myelitis Myelitis NNP cord-283202-5fq1wxz8 419 45 in in IN cord-283202-5fq1wxz8 419 46 a a DT cord-283202-5fq1wxz8 419 47 cat cat NN cord-283202-5fq1wxz8 419 48 infected infect VBN cord-283202-5fq1wxz8 419 49 with with IN cord-283202-5fq1wxz8 419 50 Toxoplasma toxoplasma JJ cord-283202-5fq1wxz8 419 51 gondii gondii NN cord-283202-5fq1wxz8 419 52 and and CC cord-283202-5fq1wxz8 419 53 feline feline JJ cord-283202-5fq1wxz8 419 54 immunodeficiency immunodeficiency NN cord-283202-5fq1wxz8 419 55 virus virus NN cord-283202-5fq1wxz8 419 56 Eosinophilic eosinophilic JJ cord-283202-5fq1wxz8 419 57 fibrosing fibrose VBG cord-283202-5fq1wxz8 419 58 gastritis gastritis NN cord-283202-5fq1wxz8 419 59 and and CC cord-283202-5fq1wxz8 419 60 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 419 61 in in IN cord-283202-5fq1wxz8 419 62 a a DT cord-283202-5fq1wxz8 419 63 cat cat NN cord-283202-5fq1wxz8 419 64 Inflammatory inflammatory JJ cord-283202-5fq1wxz8 419 65 cerebrospinal cerebrospinal JJ cord-283202-5fq1wxz8 419 66 fluid fluid NN cord-283202-5fq1wxz8 419 67 analysis analysis NN cord-283202-5fq1wxz8 419 68 in in IN cord-283202-5fq1wxz8 419 69 cats cat NNS cord-283202-5fq1wxz8 419 70 : : : cord-283202-5fq1wxz8 419 71 clinical clinical JJ cord-283202-5fq1wxz8 419 72 diagnosis diagnosis NN cord-283202-5fq1wxz8 419 73 and and CC cord-283202-5fq1wxz8 419 74 outcome outcome NN cord-283202-5fq1wxz8 419 75 Intracranial intracranial JJ cord-283202-5fq1wxz8 419 76 Toxoplasma Toxoplasma NNP cord-283202-5fq1wxz8 419 77 gondii gondii NN cord-283202-5fq1wxz8 419 78 granuloma granuloma NN cord-283202-5fq1wxz8 419 79 in in IN cord-283202-5fq1wxz8 419 80 a a DT cord-283202-5fq1wxz8 419 81 cat cat NN cord-283202-5fq1wxz8 420 1 An an DT cord-283202-5fq1wxz8 420 2 unusual unusual JJ cord-283202-5fq1wxz8 420 3 case case NN cord-283202-5fq1wxz8 420 4 of of IN cord-283202-5fq1wxz8 420 5 acute acute JJ cord-283202-5fq1wxz8 420 6 disseminated disseminate VBN cord-283202-5fq1wxz8 420 7 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 420 8 in in IN cord-283202-5fq1wxz8 420 9 a a DT cord-283202-5fq1wxz8 420 10 cat cat NN cord-283202-5fq1wxz8 420 11 Feline feline JJ cord-283202-5fq1wxz8 420 12 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 420 13 : : : cord-283202-5fq1wxz8 420 14 interpretation interpretation NN cord-283202-5fq1wxz8 420 15 of of IN cord-283202-5fq1wxz8 420 16 diagnostic diagnostic JJ cord-283202-5fq1wxz8 420 17 test test NN cord-283202-5fq1wxz8 420 18 results result NNS cord-283202-5fq1wxz8 420 19 Effect effect NN cord-283202-5fq1wxz8 420 20 of of IN cord-283202-5fq1wxz8 420 21 feline feline JJ cord-283202-5fq1wxz8 420 22 immunodeficiency immunodeficiency NN cord-283202-5fq1wxz8 420 23 virus virus NN cord-283202-5fq1wxz8 420 24 infection infection NN cord-283202-5fq1wxz8 420 25 on on IN cord-283202-5fq1wxz8 420 26 Toxoplasma toxoplasma JJ cord-283202-5fq1wxz8 420 27 gondii gondii NN cord-283202-5fq1wxz8 420 28 - - HYPH cord-283202-5fq1wxz8 420 29 specific specific JJ cord-283202-5fq1wxz8 420 30 humoral humoral JJ cord-283202-5fq1wxz8 420 31 and and CC cord-283202-5fq1wxz8 420 32 cell cell NN cord-283202-5fq1wxz8 420 33 - - HYPH cord-283202-5fq1wxz8 420 34 mediated mediate VBN cord-283202-5fq1wxz8 420 35 immune immune JJ cord-283202-5fq1wxz8 420 36 responses response NNS cord-283202-5fq1wxz8 420 37 of of IN cord-283202-5fq1wxz8 420 38 cats cat NNS cord-283202-5fq1wxz8 420 39 with with IN cord-283202-5fq1wxz8 420 40 serologic serologic JJ cord-283202-5fq1wxz8 420 41 evidence evidence NN cord-283202-5fq1wxz8 420 42 of of IN cord-283202-5fq1wxz8 420 43 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 420 44 Long long JJ cord-283202-5fq1wxz8 420 45 - - HYPH cord-283202-5fq1wxz8 420 46 term term NN cord-283202-5fq1wxz8 420 47 antibody antibody NN cord-283202-5fq1wxz8 420 48 responses response NNS cord-283202-5fq1wxz8 420 49 of of IN cord-283202-5fq1wxz8 420 50 cats cat NNS cord-283202-5fq1wxz8 420 51 fed feed VBD cord-283202-5fq1wxz8 420 52 Toxoplasma Toxoplasma NNP cord-283202-5fq1wxz8 420 53 gondii gondii NN cord-283202-5fq1wxz8 420 54 tissue tissue NN cord-283202-5fq1wxz8 420 55 cysts cyst NNS cord-283202-5fq1wxz8 420 56 Sequential sequential JJ cord-283202-5fq1wxz8 420 57 measurement measurement NN cord-283202-5fq1wxz8 420 58 of of IN cord-283202-5fq1wxz8 420 59 Toxoplasma toxoplasma JJ cord-283202-5fq1wxz8 420 60 gondii gondii NN cord-283202-5fq1wxz8 420 61 - - HYPH cord-283202-5fq1wxz8 420 62 specific specific JJ cord-283202-5fq1wxz8 420 63 antibodies antibody NNS cord-283202-5fq1wxz8 420 64 in in IN cord-283202-5fq1wxz8 420 65 the the DT cord-283202-5fq1wxz8 420 66 cerebrospinal cerebrospinal JJ cord-283202-5fq1wxz8 420 67 fluid fluid NN cord-283202-5fq1wxz8 420 68 of of IN cord-283202-5fq1wxz8 420 69 cats cat NNS cord-283202-5fq1wxz8 420 70 with with IN cord-283202-5fq1wxz8 420 71 experimentally experimentally RB cord-283202-5fq1wxz8 420 72 induced induce VBN cord-283202-5fq1wxz8 420 73 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 420 74 Feline feline JJ cord-283202-5fq1wxz8 420 75 ocular ocular JJ cord-283202-5fq1wxz8 420 76 and and CC cord-283202-5fq1wxz8 420 77 cerebrospinal cerebrospinal JJ cord-283202-5fq1wxz8 420 78 fluid fluid JJ cord-283202-5fq1wxz8 420 79 Toxoplasma toxoplasma NN cord-283202-5fq1wxz8 420 80 gondii gondii NN cord-283202-5fq1wxz8 420 81 - - HYPH cord-283202-5fq1wxz8 420 82 specific specific JJ cord-283202-5fq1wxz8 420 83 humoral humoral JJ cord-283202-5fq1wxz8 420 84 immune immune JJ cord-283202-5fq1wxz8 420 85 responses response NNS cord-283202-5fq1wxz8 420 86 following follow VBG cord-283202-5fq1wxz8 420 87 specific specific JJ cord-283202-5fq1wxz8 420 88 and and CC cord-283202-5fq1wxz8 420 89 nonspecific nonspecific JJ cord-283202-5fq1wxz8 420 90 immune immune JJ cord-283202-5fq1wxz8 420 91 stimulation stimulation NN cord-283202-5fq1wxz8 420 92 Polymerase polymerase NN cord-283202-5fq1wxz8 420 93 chain chain NN cord-283202-5fq1wxz8 420 94 reaction reaction NN cord-283202-5fq1wxz8 420 95 for for IN cord-283202-5fq1wxz8 420 96 the the DT cord-283202-5fq1wxz8 420 97 detection detection NN cord-283202-5fq1wxz8 420 98 of of IN cord-283202-5fq1wxz8 420 99 Toxoplasma toxoplasma JJ cord-283202-5fq1wxz8 420 100 gondii gondii NN cord-283202-5fq1wxz8 420 101 within within IN cord-283202-5fq1wxz8 420 102 aqueous aqueous JJ cord-283202-5fq1wxz8 420 103 humor humor NN cord-283202-5fq1wxz8 420 104 of of IN cord-283202-5fq1wxz8 420 105 experimentally experimentally RB cord-283202-5fq1wxz8 420 106 - - HYPH cord-283202-5fq1wxz8 420 107 inoculated inoculate VBN cord-283202-5fq1wxz8 420 108 cats cat NNS cord-283202-5fq1wxz8 420 109 Polymerase Polymerase NNP cord-283202-5fq1wxz8 420 110 chain chain NN cord-283202-5fq1wxz8 420 111 reaction reaction NN cord-283202-5fq1wxz8 420 112 for for IN cord-283202-5fq1wxz8 420 113 the the DT cord-283202-5fq1wxz8 420 114 detection detection NN cord-283202-5fq1wxz8 420 115 of of IN cord-283202-5fq1wxz8 420 116 Toxoplasma toxoplasma JJ cord-283202-5fq1wxz8 420 117 gondii gondii NN cord-283202-5fq1wxz8 420 118 in in IN cord-283202-5fq1wxz8 420 119 aqueous aqueous JJ cord-283202-5fq1wxz8 420 120 humor humor NN cord-283202-5fq1wxz8 420 121 of of IN cord-283202-5fq1wxz8 420 122 cats cat NNS cord-283202-5fq1wxz8 420 123 Pharmacologic Pharmacologic NNP cord-283202-5fq1wxz8 420 124 features feature NNS cord-283202-5fq1wxz8 420 125 of of IN cord-283202-5fq1wxz8 420 126 clindamycin clindamycin NN cord-283202-5fq1wxz8 420 127 in in IN cord-283202-5fq1wxz8 420 128 dogs dog NNS cord-283202-5fq1wxz8 420 129 and and CC cord-283202-5fq1wxz8 420 130 cats cat NNS cord-283202-5fq1wxz8 421 1 Paradoxical paradoxical JJ cord-283202-5fq1wxz8 421 2 effect effect NN cord-283202-5fq1wxz8 421 3 of of IN cord-283202-5fq1wxz8 421 4 clindamycin clindamycin NN cord-283202-5fq1wxz8 421 5 in in IN cord-283202-5fq1wxz8 421 6 experimental experimental JJ cord-283202-5fq1wxz8 421 7 , , , cord-283202-5fq1wxz8 421 8 acute acute JJ cord-283202-5fq1wxz8 421 9 toxoplasmosis toxoplasmosis NN cord-283202-5fq1wxz8 421 10 in in IN cord-283202-5fq1wxz8 421 11 cats cat NNS cord-283202-5fq1wxz8 421 12 Tissue tissue NN cord-283202-5fq1wxz8 421 13 concentrations concentration NNS cord-283202-5fq1wxz8 421 14 of of IN cord-283202-5fq1wxz8 421 15 clindamycin clindamycin NN cord-283202-5fq1wxz8 421 16 after after IN cord-283202-5fq1wxz8 421 17 multiple multiple JJ cord-283202-5fq1wxz8 421 18 oral oral JJ cord-283202-5fq1wxz8 421 19 doses dose NNS cord-283202-5fq1wxz8 421 20 in in IN cord-283202-5fq1wxz8 421 21 normal normal JJ cord-283202-5fq1wxz8 421 22 cats cat NNS cord-283202-5fq1wxz8 421 23 Chloramphenicol Chloramphenicol NNP cord-283202-5fq1wxz8 421 24 and and CC cord-283202-5fq1wxz8 421 25 derivatives derivative NNS cord-283202-5fq1wxz8 421 26 , , , cord-283202-5fq1wxz8 421 27 macrolides macrolide NNS cord-283202-5fq1wxz8 421 28 , , , cord-283202-5fq1wxz8 421 29 lincosamides lincosamide NNS cord-283202-5fq1wxz8 421 30 , , , cord-283202-5fq1wxz8 421 31 and and CC cord-283202-5fq1wxz8 421 32 miscellaneous miscellaneous JJ cord-283202-5fq1wxz8 421 33 antimicrobials antimicrobial NNS cord-283202-5fq1wxz8 421 34 Effect Effect NNP cord-283202-5fq1wxz8 421 35 of of IN cord-283202-5fq1wxz8 421 36 clindamycin clindamycin NN cord-283202-5fq1wxz8 421 37 on on IN cord-283202-5fq1wxz8 421 38 clinical clinical JJ cord-283202-5fq1wxz8 421 39 , , , cord-283202-5fq1wxz8 421 40 hematological hematological JJ cord-283202-5fq1wxz8 421 41 , , , cord-283202-5fq1wxz8 421 42 and and CC cord-283202-5fq1wxz8 421 43 biochemical biochemical JJ cord-283202-5fq1wxz8 421 44 parameters parameter NNS cord-283202-5fq1wxz8 421 45 in in IN cord-283202-5fq1wxz8 421 46 clinically clinically RB cord-283202-5fq1wxz8 421 47 healthy healthy JJ cord-283202-5fq1wxz8 421 48 cats cat NNS cord-283202-5fq1wxz8 421 49 Encephalitic encephalitic JJ cord-283202-5fq1wxz8 421 50 toxoplasmosis toxoplasmosi NNS cord-283202-5fq1wxz8 421 51 in in IN cord-283202-5fq1wxz8 421 52 a a DT cord-283202-5fq1wxz8 421 53 cat cat NN cord-283202-5fq1wxz8 421 54 Systemic systemic JJ cord-283202-5fq1wxz8 421 55 hypertension hypertension NN cord-283202-5fq1wxz8 421 56 in in IN cord-283202-5fq1wxz8 421 57 four four CD cord-283202-5fq1wxz8 421 58 cats cat NNS cord-283202-5fq1wxz8 421 59 : : : cord-283202-5fq1wxz8 421 60 ocular ocular JJ cord-283202-5fq1wxz8 421 61 and and CC cord-283202-5fq1wxz8 421 62 medical medical JJ cord-283202-5fq1wxz8 421 63 findings finding NNS cord-283202-5fq1wxz8 421 64 Guidelines guideline NNS cord-283202-5fq1wxz8 421 65 for for IN cord-283202-5fq1wxz8 421 66 the the DT cord-283202-5fq1wxz8 421 67 identification identification NN cord-283202-5fq1wxz8 421 68 , , , cord-283202-5fq1wxz8 421 69 evaluation evaluation NN cord-283202-5fq1wxz8 421 70 , , , cord-283202-5fq1wxz8 421 71 and and CC cord-283202-5fq1wxz8 421 72 management management NN cord-283202-5fq1wxz8 421 73 of of IN cord-283202-5fq1wxz8 421 74 systemic systemic JJ cord-283202-5fq1wxz8 421 75 hypertension hypertension NN cord-283202-5fq1wxz8 421 76 in in IN cord-283202-5fq1wxz8 421 77 dogs dog NNS cord-283202-5fq1wxz8 421 78 and and CC cord-283202-5fq1wxz8 421 79 cats cat NNS cord-283202-5fq1wxz8 421 80 Effects effect NNS cord-283202-5fq1wxz8 421 81 of of IN cord-283202-5fq1wxz8 421 82 certain certain JJ cord-283202-5fq1wxz8 421 83 vasoactive vasoactive JJ cord-283202-5fq1wxz8 421 84 agents agent NNS cord-283202-5fq1wxz8 421 85 on on IN cord-283202-5fq1wxz8 421 86 the the DT cord-283202-5fq1wxz8 421 87 long long JJ cord-283202-5fq1wxz8 421 88 - - HYPH cord-283202-5fq1wxz8 421 89 term term NN cord-283202-5fq1wxz8 421 90 pattern pattern NN cord-283202-5fq1wxz8 421 91 of of IN cord-283202-5fq1wxz8 421 92 blood blood NN cord-283202-5fq1wxz8 421 93 pressure pressure NN cord-283202-5fq1wxz8 421 94 , , , cord-283202-5fq1wxz8 421 95 heart heart NN cord-283202-5fq1wxz8 421 96 rate rate NN cord-283202-5fq1wxz8 421 97 , , , cord-283202-5fq1wxz8 421 98 and and CC cord-283202-5fq1wxz8 421 99 motor motor NN cord-283202-5fq1wxz8 421 100 activity activity NN cord-283202-5fq1wxz8 421 101 in in IN cord-283202-5fq1wxz8 421 102 cats cat NNS cord-283202-5fq1wxz8 421 103 Non non JJ cord-283202-5fq1wxz8 421 104 - - JJ cord-283202-5fq1wxz8 421 105 invasive invasive JJ cord-283202-5fq1wxz8 421 106 blood blood NN cord-283202-5fq1wxz8 421 107 pressure pressure NN cord-283202-5fq1wxz8 421 108 measurements measurement NNS cord-283202-5fq1wxz8 421 109 in in IN cord-283202-5fq1wxz8 421 110 cats cat NNS cord-283202-5fq1wxz8 421 111 : : : cord-283202-5fq1wxz8 421 112 clinical clinical JJ cord-283202-5fq1wxz8 421 113 significance significance NN cord-283202-5fq1wxz8 421 114 of of IN cord-283202-5fq1wxz8 421 115 hypertension hypertension NN cord-283202-5fq1wxz8 421 116 associated associate VBN cord-283202-5fq1wxz8 421 117 with with IN cord-283202-5fq1wxz8 421 118 chronic chronic JJ cord-283202-5fq1wxz8 421 119 renal renal JJ cord-283202-5fq1wxz8 421 120 failure failure NN cord-283202-5fq1wxz8 421 121 Hypertension hypertension NN cord-283202-5fq1wxz8 421 122 in in IN cord-283202-5fq1wxz8 421 123 cats cat NNS cord-283202-5fq1wxz8 421 124 with with IN cord-283202-5fq1wxz8 421 125 chronic chronic JJ cord-283202-5fq1wxz8 421 126 renal renal JJ cord-283202-5fq1wxz8 421 127 failure failure NN cord-283202-5fq1wxz8 421 128 or or CC cord-283202-5fq1wxz8 421 129 hyperthyroidism hyperthyroidism NN cord-283202-5fq1wxz8 421 130 Inter Inter NNP cord-283202-5fq1wxz8 421 131 - - : cord-283202-5fq1wxz8 421 132 and and CC cord-283202-5fq1wxz8 421 133 intraindividual intraindividual JJ cord-283202-5fq1wxz8 421 134 variation variation NN cord-283202-5fq1wxz8 421 135 in in IN cord-283202-5fq1wxz8 421 136 Doppler Doppler NNP cord-283202-5fq1wxz8 421 137 ultrasonic ultrasonic JJ cord-283202-5fq1wxz8 421 138 indirect indirect JJ cord-283202-5fq1wxz8 421 139 blood blood NN cord-283202-5fq1wxz8 421 140 pressure pressure NN cord-283202-5fq1wxz8 421 141 measurements measurement NNS cord-283202-5fq1wxz8 421 142 in in IN cord-283202-5fq1wxz8 421 143 healthy healthy JJ cord-283202-5fq1wxz8 421 144 cats cat NNS cord-283202-5fq1wxz8 422 1 Epidemiological epidemiological JJ cord-283202-5fq1wxz8 422 2 study study NN cord-283202-5fq1wxz8 422 3 of of IN cord-283202-5fq1wxz8 422 4 blood blood NN cord-283202-5fq1wxz8 422 5 pressure pressure NN cord-283202-5fq1wxz8 422 6 in in IN cord-283202-5fq1wxz8 422 7 domestic domestic JJ cord-283202-5fq1wxz8 422 8 cats cat NNS cord-283202-5fq1wxz8 422 9 Evaluation Evaluation NNP cord-283202-5fq1wxz8 422 10 of of IN cord-283202-5fq1wxz8 422 11 the the DT cord-283202-5fq1wxz8 422 12 white white JJ cord-283202-5fq1wxz8 422 13 - - HYPH cord-283202-5fq1wxz8 422 14 coat coat NN cord-283202-5fq1wxz8 422 15 effect effect NN cord-283202-5fq1wxz8 422 16 in in IN cord-283202-5fq1wxz8 422 17 cats cat NNS cord-283202-5fq1wxz8 422 18 Feline feline JJ cord-283202-5fq1wxz8 422 19 hypertension hypertension NN cord-283202-5fq1wxz8 422 20 : : : cord-283202-5fq1wxz8 422 21 clinical clinical JJ cord-283202-5fq1wxz8 422 22 findings finding NNS cord-283202-5fq1wxz8 422 23 and and CC cord-283202-5fq1wxz8 422 24 response response NN cord-283202-5fq1wxz8 422 25 to to IN cord-283202-5fq1wxz8 422 26 antihypertensive antihypertensive JJ cord-283202-5fq1wxz8 422 27 treatment treatment NN cord-283202-5fq1wxz8 422 28 in in IN cord-283202-5fq1wxz8 422 29 30 30 CD cord-283202-5fq1wxz8 422 30 cases case NNS cord-283202-5fq1wxz8 422 31 Spontaneous spontaneous JJ cord-283202-5fq1wxz8 422 32 systemic systemic JJ cord-283202-5fq1wxz8 422 33 hypertension hypertension NN cord-283202-5fq1wxz8 422 34 in in IN cord-283202-5fq1wxz8 422 35 24 24 CD cord-283202-5fq1wxz8 422 36 cats cat NNS cord-283202-5fq1wxz8 422 37 Management Management NNP cord-283202-5fq1wxz8 422 38 of of IN cord-283202-5fq1wxz8 422 39 hypertension hypertension NN cord-283202-5fq1wxz8 422 40 controls control NNS cord-283202-5fq1wxz8 422 41 postoperative postoperative JJ cord-283202-5fq1wxz8 422 42 neurologic neurologic JJ cord-283202-5fq1wxz8 422 43 disorders disorder NNS cord-283202-5fq1wxz8 422 44 after after IN cord-283202-5fq1wxz8 422 45 renal renal JJ cord-283202-5fq1wxz8 422 46 transplantation transplantation NN cord-283202-5fq1wxz8 422 47 in in IN cord-283202-5fq1wxz8 422 48 cats cat NNS cord-283202-5fq1wxz8 422 49 Central central JJ cord-283202-5fq1wxz8 422 50 nervous nervous JJ cord-283202-5fq1wxz8 422 51 system system NN cord-283202-5fq1wxz8 422 52 disorders disorder NNS cord-283202-5fq1wxz8 422 53 after after IN cord-283202-5fq1wxz8 422 54 renal renal JJ cord-283202-5fq1wxz8 422 55 transplantation transplantation NN cord-283202-5fq1wxz8 422 56 in in IN cord-283202-5fq1wxz8 422 57 cats cat NNS cord-283202-5fq1wxz8 422 58 Renal renal JJ cord-283202-5fq1wxz8 422 59 transplants transplant NNS cord-283202-5fq1wxz8 422 60 in in IN cord-283202-5fq1wxz8 422 61 cats cat NNS cord-283202-5fq1wxz8 422 62 : : : cord-283202-5fq1wxz8 422 63 66 66 CD cord-283202-5fq1wxz8 422 64 cases case NNS cord-283202-5fq1wxz8 422 65 ( ( -LRB- cord-283202-5fq1wxz8 422 66 1987 1987 CD cord-283202-5fq1wxz8 422 67 - - SYM cord-283202-5fq1wxz8 422 68 1996 1996 CD cord-283202-5fq1wxz8 422 69 ) ) -RRB- cord-283202-5fq1wxz8 423 1 Use use NN cord-283202-5fq1wxz8 423 2 of of IN cord-283202-5fq1wxz8 423 3 recombinant recombinant JJ cord-283202-5fq1wxz8 423 4 human human JJ cord-283202-5fq1wxz8 423 5 erythropoietin erythropoietin NN cord-283202-5fq1wxz8 423 6 for for IN cord-283202-5fq1wxz8 423 7 management management NN cord-283202-5fq1wxz8 423 8 of of IN cord-283202-5fq1wxz8 423 9 anemia anemia NN cord-283202-5fq1wxz8 423 10 in in IN cord-283202-5fq1wxz8 423 11 dogs dog NNS cord-283202-5fq1wxz8 423 12 and and CC cord-283202-5fq1wxz8 423 13 cats cat NNS cord-283202-5fq1wxz8 423 14 with with IN cord-283202-5fq1wxz8 423 15 renal renal JJ cord-283202-5fq1wxz8 423 16 failure failure NN cord-283202-5fq1wxz8 424 1 Primary primary JJ cord-283202-5fq1wxz8 424 2 hyperaldosteronism hyperaldosteronism NN cord-283202-5fq1wxz8 424 3 in in IN cord-283202-5fq1wxz8 424 4 two two CD cord-283202-5fq1wxz8 424 5 cats cat NNS cord-283202-5fq1wxz8 424 6 Ocular ocular JJ cord-283202-5fq1wxz8 424 7 lesions lesion NNS cord-283202-5fq1wxz8 424 8 associated associate VBN cord-283202-5fq1wxz8 424 9 with with IN cord-283202-5fq1wxz8 424 10 systemic systemic JJ cord-283202-5fq1wxz8 424 11 hypertension hypertension NN cord-283202-5fq1wxz8 424 12 in in IN cord-283202-5fq1wxz8 424 13 cats cat NNS cord-283202-5fq1wxz8 424 14 : : : cord-283202-5fq1wxz8 425 1 69 69 CD cord-283202-5fq1wxz8 425 2 cases case NNS cord-283202-5fq1wxz8 425 3 ( ( -LRB- cord-283202-5fq1wxz8 425 4 1985 1985 CD cord-283202-5fq1wxz8 425 5 - - SYM cord-283202-5fq1wxz8 425 6 1998 1998 CD cord-283202-5fq1wxz8 425 7 ) ) -RRB- cord-283202-5fq1wxz8 425 8 Hypertension hypertension NN cord-283202-5fq1wxz8 425 9 and and CC cord-283202-5fq1wxz8 425 10 renal renal JJ cord-283202-5fq1wxz8 425 11 disease disease NN cord-283202-5fq1wxz8 425 12 Idiopathic idiopathic JJ cord-283202-5fq1wxz8 425 13 hypertension hypertension NN cord-283202-5fq1wxz8 425 14 in in IN cord-283202-5fq1wxz8 425 15 a a DT cord-283202-5fq1wxz8 425 16 cat cat NN cord-283202-5fq1wxz8 425 17 with with IN cord-283202-5fq1wxz8 425 18 secondary secondary JJ cord-283202-5fq1wxz8 425 19 hypertensive hypertensive JJ cord-283202-5fq1wxz8 425 20 retinopathy retinopathy NN cord-283202-5fq1wxz8 425 21 associated associate VBN cord-283202-5fq1wxz8 425 22 with with IN cord-283202-5fq1wxz8 425 23 a a DT cord-283202-5fq1wxz8 425 24 high high JJ cord-283202-5fq1wxz8 425 25 - - HYPH cord-283202-5fq1wxz8 425 26 salt salt NN cord-283202-5fq1wxz8 425 27 diet diet NN cord-283202-5fq1wxz8 426 1 The the DT cord-283202-5fq1wxz8 426 2 prevalence prevalence NN cord-283202-5fq1wxz8 426 3 of of IN cord-283202-5fq1wxz8 426 4 retinopathy retinopathy NN cord-283202-5fq1wxz8 426 5 in in IN cord-283202-5fq1wxz8 426 6 cats cat NNS cord-283202-5fq1wxz8 426 7 with with IN cord-283202-5fq1wxz8 426 8 systemic systemic JJ cord-283202-5fq1wxz8 426 9 hypertension hypertension NN cord-283202-5fq1wxz8 426 10 and and CC cord-283202-5fq1wxz8 426 11 chronic chronic JJ cord-283202-5fq1wxz8 426 12 renal renal JJ cord-283202-5fq1wxz8 426 13 failure failure NN cord-283202-5fq1wxz8 426 14 or or CC cord-283202-5fq1wxz8 426 15 hyperthyroidism hyperthyroidism NN cord-283202-5fq1wxz8 426 16 Ocular ocular JJ cord-283202-5fq1wxz8 426 17 disease disease NN cord-283202-5fq1wxz8 426 18 associated associate VBN cord-283202-5fq1wxz8 426 19 with with IN cord-283202-5fq1wxz8 426 20 hypertension hypertension NN cord-283202-5fq1wxz8 426 21 in in IN cord-283202-5fq1wxz8 426 22 16 16 CD cord-283202-5fq1wxz8 426 23 cats cat NNS cord-283202-5fq1wxz8 426 24 Spectrum Spectrum NNP cord-283202-5fq1wxz8 426 25 of of IN cord-283202-5fq1wxz8 426 26 M M NNP cord-283202-5fq1wxz8 426 27 - - HYPH cord-283202-5fq1wxz8 426 28 mode mode NN cord-283202-5fq1wxz8 426 29 echocardiographic echocardiographic JJ cord-283202-5fq1wxz8 426 30 abnormalities abnormality NNS cord-283202-5fq1wxz8 426 31 in in IN cord-283202-5fq1wxz8 426 32 75 75 CD cord-283202-5fq1wxz8 426 33 cats cat NNS cord-283202-5fq1wxz8 426 34 with with IN cord-283202-5fq1wxz8 426 35 systemic systemic JJ cord-283202-5fq1wxz8 426 36 hypertension hypertension NN cord-283202-5fq1wxz8 426 37 Hypertensive hypertensive JJ cord-283202-5fq1wxz8 426 38 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 426 39 in in IN cord-283202-5fq1wxz8 426 40 cats cat NNS cord-283202-5fq1wxz8 426 41 with with IN cord-283202-5fq1wxz8 426 42 reduced reduce VBN cord-283202-5fq1wxz8 426 43 renal renal JJ cord-283202-5fq1wxz8 426 44 function function NN cord-283202-5fq1wxz8 426 45 A a DT cord-283202-5fq1wxz8 426 46 reversible reversible JJ cord-283202-5fq1wxz8 426 47 posterior posterior JJ cord-283202-5fq1wxz8 426 48 leukoencephalopathy leukoencephalopathy NNP cord-283202-5fq1wxz8 426 49 syndrome syndrome NN cord-283202-5fq1wxz8 427 1 Brainstem Brainstem NNP cord-283202-5fq1wxz8 427 2 involvement involvement NN cord-283202-5fq1wxz8 427 3 in in IN cord-283202-5fq1wxz8 427 4 hypertensive hypertensive JJ cord-283202-5fq1wxz8 427 5 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 427 6 : : : cord-283202-5fq1wxz8 427 7 a a DT cord-283202-5fq1wxz8 427 8 report report NN cord-283202-5fq1wxz8 427 9 of of IN cord-283202-5fq1wxz8 427 10 two two CD cord-283202-5fq1wxz8 427 11 cases case NNS cord-283202-5fq1wxz8 427 12 and and CC cord-283202-5fq1wxz8 427 13 literature literature NN cord-283202-5fq1wxz8 427 14 review review NN cord-283202-5fq1wxz8 427 15 The the DT cord-283202-5fq1wxz8 427 16 blood blood NN cord-283202-5fq1wxz8 427 17 - - HYPH cord-283202-5fq1wxz8 427 18 brain brain NN cord-283202-5fq1wxz8 427 19 barrier barrier NN cord-283202-5fq1wxz8 427 20 and and CC cord-283202-5fq1wxz8 427 21 cerebral cerebral JJ cord-283202-5fq1wxz8 427 22 blood blood NN cord-283202-5fq1wxz8 427 23 flow flow NN cord-283202-5fq1wxz8 427 24 in in IN cord-283202-5fq1wxz8 427 25 acute acute JJ cord-283202-5fq1wxz8 427 26 hypertension hypertension NN cord-283202-5fq1wxz8 427 27 Hypertension hypertension NN cord-283202-5fq1wxz8 427 28 in in IN cord-283202-5fq1wxz8 427 29 renal renal JJ cord-283202-5fq1wxz8 427 30 disease disease NN cord-283202-5fq1wxz8 427 31 : : : cord-283202-5fq1wxz8 427 32 diagnosis diagnosis NN cord-283202-5fq1wxz8 427 33 and and CC cord-283202-5fq1wxz8 427 34 treatment treatment NN cord-283202-5fq1wxz8 427 35 Posterior posterior JJ cord-283202-5fq1wxz8 427 36 reversible reversible JJ cord-283202-5fq1wxz8 427 37 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 427 38 syndrome syndrome NN cord-283202-5fq1wxz8 427 39 , , , cord-283202-5fq1wxz8 427 40 part part NN cord-283202-5fq1wxz8 427 41 1 1 CD cord-283202-5fq1wxz8 427 42 : : : cord-283202-5fq1wxz8 427 43 Fundamental fundamental JJ cord-283202-5fq1wxz8 427 44 imaging imaging NN cord-283202-5fq1wxz8 427 45 and and CC cord-283202-5fq1wxz8 427 46 clinical clinical JJ cord-283202-5fq1wxz8 427 47 features feature NNS cord-283202-5fq1wxz8 428 1 Amlodipine Amlodipine NNP cord-283202-5fq1wxz8 428 2 : : : cord-283202-5fq1wxz8 429 1 a a DT cord-283202-5fq1wxz8 429 2 randomized randomized JJ cord-283202-5fq1wxz8 429 3 , , , cord-283202-5fq1wxz8 429 4 blinded blind VBN cord-283202-5fq1wxz8 429 5 clinical clinical JJ cord-283202-5fq1wxz8 429 6 trial trial NN cord-283202-5fq1wxz8 429 7 in in IN cord-283202-5fq1wxz8 429 8 9 9 CD cord-283202-5fq1wxz8 429 9 cats cat NNS cord-283202-5fq1wxz8 429 10 with with IN cord-283202-5fq1wxz8 429 11 systemic systemic JJ cord-283202-5fq1wxz8 429 12 hypertension hypertension NN cord-283202-5fq1wxz8 429 13 Effect effect NN cord-283202-5fq1wxz8 429 14 of of IN cord-283202-5fq1wxz8 429 15 amlodipine amlodipine NN cord-283202-5fq1wxz8 429 16 on on IN cord-283202-5fq1wxz8 429 17 echocardiographic echocardiographic JJ cord-283202-5fq1wxz8 429 18 variables variable NNS cord-283202-5fq1wxz8 429 19 in in IN cord-283202-5fq1wxz8 429 20 cats cat NNS cord-283202-5fq1wxz8 429 21 with with IN cord-283202-5fq1wxz8 429 22 systemic systemic JJ cord-283202-5fq1wxz8 429 23 hypertension hypertension NN cord-283202-5fq1wxz8 429 24 Treatment treatment NN cord-283202-5fq1wxz8 429 25 of of IN cord-283202-5fq1wxz8 429 26 systemic systemic JJ cord-283202-5fq1wxz8 429 27 hypertension hypertension NN cord-283202-5fq1wxz8 429 28 in in IN cord-283202-5fq1wxz8 429 29 cats cat NNS cord-283202-5fq1wxz8 429 30 with with IN cord-283202-5fq1wxz8 429 31 amlodipine amlodipine NN cord-283202-5fq1wxz8 429 32 besylate besylate NNP cord-283202-5fq1wxz8 429 33 Effects effect NNS cord-283202-5fq1wxz8 429 34 of of IN cord-283202-5fq1wxz8 429 35 the the DT cord-283202-5fq1wxz8 429 36 calcium calcium NN cord-283202-5fq1wxz8 429 37 channel channel NN cord-283202-5fq1wxz8 429 38 antagonist antagonist NN cord-283202-5fq1wxz8 429 39 amlodipine amlodipine NN cord-283202-5fq1wxz8 429 40 in in IN cord-283202-5fq1wxz8 429 41 cats cat NNS cord-283202-5fq1wxz8 429 42 with with IN cord-283202-5fq1wxz8 429 43 surgically surgically RB cord-283202-5fq1wxz8 429 44 induced induce VBN cord-283202-5fq1wxz8 429 45 hypertensive hypertensive JJ cord-283202-5fq1wxz8 429 46 renal renal JJ cord-283202-5fq1wxz8 429 47 insufficiency insufficiency NN cord-283202-5fq1wxz8 429 48 Diagnosis diagnosis NN cord-283202-5fq1wxz8 429 49 and and CC cord-283202-5fq1wxz8 429 50 treatment treatment NN cord-283202-5fq1wxz8 429 51 of of IN cord-283202-5fq1wxz8 429 52 systemic systemic JJ cord-283202-5fq1wxz8 429 53 hypertension hypertension NN cord-283202-5fq1wxz8 429 54 Effects effect NNS cord-283202-5fq1wxz8 429 55 of of IN cord-283202-5fq1wxz8 429 56 the the DT cord-283202-5fq1wxz8 429 57 angiotensin angiotensin NN cord-283202-5fq1wxz8 429 58 converting convert VBG cord-283202-5fq1wxz8 429 59 enzyme enzyme NN cord-283202-5fq1wxz8 429 60 inhibitor inhibitor NN cord-283202-5fq1wxz8 429 61 benazepril benazepril NNP cord-283202-5fq1wxz8 429 62 in in IN cord-283202-5fq1wxz8 429 63 cats cat NNS cord-283202-5fq1wxz8 429 64 with with IN cord-283202-5fq1wxz8 429 65 induced induce VBN cord-283202-5fq1wxz8 429 66 renal renal JJ cord-283202-5fq1wxz8 429 67 insufficiency insufficiency NN cord-283202-5fq1wxz8 429 68 Pathophysiologic Pathophysiologic NNP cord-283202-5fq1wxz8 429 69 sequelae sequela NNS cord-283202-5fq1wxz8 429 70 of of IN cord-283202-5fq1wxz8 429 71 intracranial intracranial JJ cord-283202-5fq1wxz8 429 72 disease disease NN cord-283202-5fq1wxz8 429 73 Effect effect NN cord-283202-5fq1wxz8 429 74 of of IN cord-283202-5fq1wxz8 429 75 control control NN cord-283202-5fq1wxz8 429 76 of of IN cord-283202-5fq1wxz8 429 77 systolic systolic JJ cord-283202-5fq1wxz8 429 78 blood blood NN cord-283202-5fq1wxz8 429 79 pressure pressure NN cord-283202-5fq1wxz8 429 80 on on IN cord-283202-5fq1wxz8 429 81 survival survival NN cord-283202-5fq1wxz8 429 82 in in IN cord-283202-5fq1wxz8 429 83 cats cat NNS cord-283202-5fq1wxz8 429 84 with with IN cord-283202-5fq1wxz8 429 85 systemic systemic JJ cord-283202-5fq1wxz8 429 86 hypertension hypertension NN cord-283202-5fq1wxz8 429 87 Survival survival NN cord-283202-5fq1wxz8 429 88 of of IN cord-283202-5fq1wxz8 429 89 cats cat NNS cord-283202-5fq1wxz8 429 90 with with IN cord-283202-5fq1wxz8 429 91 naturally naturally RB cord-283202-5fq1wxz8 429 92 occurring occur VBG cord-283202-5fq1wxz8 429 93 chronic chronic JJ cord-283202-5fq1wxz8 429 94 renal renal JJ cord-283202-5fq1wxz8 429 95 failure failure NN cord-283202-5fq1wxz8 429 96 is be VBZ cord-283202-5fq1wxz8 429 97 related relate VBN cord-283202-5fq1wxz8 429 98 to to IN cord-283202-5fq1wxz8 429 99 severity severity NN cord-283202-5fq1wxz8 429 100 of of IN cord-283202-5fq1wxz8 429 101 proteinuria proteinuria NN cord-283202-5fq1wxz8 429 102 The the DT cord-283202-5fq1wxz8 429 103 molecular molecular JJ cord-283202-5fq1wxz8 429 104 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 429 105 of of IN cord-283202-5fq1wxz8 429 106 hepatic hepatic JJ cord-283202-5fq1wxz8 429 107 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 429 108 Kirk Kirk NNP cord-283202-5fq1wxz8 429 109 's 's POS cord-283202-5fq1wxz8 429 110 current current JJ cord-283202-5fq1wxz8 429 111 veterinary veterinary JJ cord-283202-5fq1wxz8 429 112 therapy therapy NN cord-283202-5fq1wxz8 429 113 XII XII NNP cord-283202-5fq1wxz8 429 114 small small JJ cord-283202-5fq1wxz8 429 115 animal animal NN cord-283202-5fq1wxz8 429 116 practice practice NN cord-283202-5fq1wxz8 429 117 Historical historical JJ cord-283202-5fq1wxz8 429 118 , , , cord-283202-5fq1wxz8 429 119 physical physical JJ cord-283202-5fq1wxz8 429 120 examination examination NN cord-283202-5fq1wxz8 429 121 , , , cord-283202-5fq1wxz8 429 122 and and CC cord-283202-5fq1wxz8 429 123 clinicopathologic clinicopathologic NNP cord-283202-5fq1wxz8 429 124 features feature NNS cord-283202-5fq1wxz8 429 125 of of IN cord-283202-5fq1wxz8 429 126 portosystemic portosystemic JJ cord-283202-5fq1wxz8 429 127 vascular vascular JJ cord-283202-5fq1wxz8 429 128 anomalies anomaly NNS cord-283202-5fq1wxz8 429 129 in in IN cord-283202-5fq1wxz8 429 130 the the DT cord-283202-5fq1wxz8 429 131 dog dog NN cord-283202-5fq1wxz8 429 132 and and CC cord-283202-5fq1wxz8 429 133 cat cat NN cord-283202-5fq1wxz8 430 1 Feline feline JJ cord-283202-5fq1wxz8 430 2 portosystemic portosystemic JJ cord-283202-5fq1wxz8 430 3 shunts shunt NNS cord-283202-5fq1wxz8 431 1 Kirk Kirk NNP cord-283202-5fq1wxz8 431 2 's 's POS cord-283202-5fq1wxz8 431 3 current current JJ cord-283202-5fq1wxz8 431 4 veterinary veterinary JJ cord-283202-5fq1wxz8 431 5 therapy therapy NN cord-283202-5fq1wxz8 431 6 XII XII NNP cord-283202-5fq1wxz8 431 7 small small JJ cord-283202-5fq1wxz8 431 8 animal animal NN cord-283202-5fq1wxz8 431 9 practice practice VBP cord-283202-5fq1wxz8 431 10 Feline feline JJ cord-283202-5fq1wxz8 431 11 portosystemic portosystemic JJ cord-283202-5fq1wxz8 431 12 shunts shunt NNS cord-283202-5fq1wxz8 432 1 Surgical surgical JJ cord-283202-5fq1wxz8 432 2 treatment treatment NN cord-283202-5fq1wxz8 432 3 of of IN cord-283202-5fq1wxz8 432 4 intrahepatic intrahepatic JJ cord-283202-5fq1wxz8 432 5 portosystemic portosystemic JJ cord-283202-5fq1wxz8 432 6 shunts shunt NNS cord-283202-5fq1wxz8 432 7 in in IN cord-283202-5fq1wxz8 432 8 six six CD cord-283202-5fq1wxz8 432 9 cats cat NNS cord-283202-5fq1wxz8 432 10 Results result NNS cord-283202-5fq1wxz8 432 11 of of IN cord-283202-5fq1wxz8 432 12 surgical surgical JJ cord-283202-5fq1wxz8 432 13 management management NN cord-283202-5fq1wxz8 432 14 of of IN cord-283202-5fq1wxz8 432 15 feline feline JJ cord-283202-5fq1wxz8 432 16 portosystemic portosystemic JJ cord-283202-5fq1wxz8 432 17 shunts shunt NNS cord-283202-5fq1wxz8 432 18 Portosystemic Portosystemic NNP cord-283202-5fq1wxz8 432 19 shunts shunt NNS cord-283202-5fq1wxz8 432 20 in in IN cord-283202-5fq1wxz8 432 21 cats cat NNS cord-283202-5fq1wxz8 432 22 : : : cord-283202-5fq1wxz8 432 23 seven seven CD cord-283202-5fq1wxz8 432 24 cases case NNS cord-283202-5fq1wxz8 432 25 ( ( -LRB- cord-283202-5fq1wxz8 432 26 1976 1976 CD cord-283202-5fq1wxz8 432 27 - - SYM cord-283202-5fq1wxz8 432 28 1984 1984 CD cord-283202-5fq1wxz8 432 29 ) ) -RRB- cord-283202-5fq1wxz8 433 1 Congenital congenital JJ cord-283202-5fq1wxz8 433 2 portacaval portacaval NN cord-283202-5fq1wxz8 433 3 shunts shunt NNS cord-283202-5fq1wxz8 433 4 in in IN cord-283202-5fq1wxz8 433 5 two two CD cord-283202-5fq1wxz8 433 6 cats cat NNS cord-283202-5fq1wxz8 433 7 : : : cord-283202-5fq1wxz8 433 8 diagnosis diagnosis NN cord-283202-5fq1wxz8 433 9 and and CC cord-283202-5fq1wxz8 433 10 surgical surgical JJ cord-283202-5fq1wxz8 433 11 correction correction NN cord-283202-5fq1wxz8 433 12 Congenital congenital JJ cord-283202-5fq1wxz8 433 13 feline feline JJ cord-283202-5fq1wxz8 433 14 portosystemic portosystemic JJ cord-283202-5fq1wxz8 433 15 shunts shunt NNS cord-283202-5fq1wxz8 433 16 Complications complication NNS cord-283202-5fq1wxz8 433 17 and and CC cord-283202-5fq1wxz8 433 18 long long JJ cord-283202-5fq1wxz8 433 19 - - HYPH cord-283202-5fq1wxz8 433 20 term term NN cord-283202-5fq1wxz8 433 21 outcomes outcome NNS cord-283202-5fq1wxz8 433 22 of of IN cord-283202-5fq1wxz8 433 23 the the DT cord-283202-5fq1wxz8 433 24 ligation ligation NN cord-283202-5fq1wxz8 433 25 of of IN cord-283202-5fq1wxz8 433 26 congenital congenital JJ cord-283202-5fq1wxz8 433 27 portosystemic portosystemic JJ cord-283202-5fq1wxz8 433 28 shunts shunt NNS cord-283202-5fq1wxz8 433 29 in in IN cord-283202-5fq1wxz8 433 30 49 49 CD cord-283202-5fq1wxz8 433 31 cats cat NNS cord-283202-5fq1wxz8 433 32 Unusual unusual JJ cord-283202-5fq1wxz8 433 33 congenital congenital JJ cord-283202-5fq1wxz8 433 34 portosystemic portosystemic JJ cord-283202-5fq1wxz8 433 35 communication communication NN cord-283202-5fq1wxz8 433 36 resulting result VBG cord-283202-5fq1wxz8 433 37 from from IN cord-283202-5fq1wxz8 433 38 persistence persistence NN cord-283202-5fq1wxz8 433 39 of of IN cord-283202-5fq1wxz8 433 40 the the DT cord-283202-5fq1wxz8 433 41 extrahepatic extrahepatic JJ cord-283202-5fq1wxz8 433 42 umbilical umbilical JJ cord-283202-5fq1wxz8 433 43 vein vein NN cord-283202-5fq1wxz8 433 44 Atypical atypical JJ cord-283202-5fq1wxz8 433 45 portosystemic portosystemic JJ cord-283202-5fq1wxz8 433 46 shunt shunt NN cord-283202-5fq1wxz8 433 47 in in IN cord-283202-5fq1wxz8 433 48 a a DT cord-283202-5fq1wxz8 433 49 cat cat NN cord-283202-5fq1wxz8 433 50 Hepatic hepatic JJ cord-283202-5fq1wxz8 433 51 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 433 52 : : : cord-283202-5fq1wxz8 433 53 from from IN cord-283202-5fq1wxz8 433 54 pathophysiology pathophysiology NN cord-283202-5fq1wxz8 433 55 to to IN cord-283202-5fq1wxz8 433 56 treatment treatment NN cord-283202-5fq1wxz8 433 57 Perspectives perspective NNS cord-283202-5fq1wxz8 433 58 in in IN cord-283202-5fq1wxz8 433 59 hepatic hepatic JJ cord-283202-5fq1wxz8 433 60 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 434 1 Hepatic hepatic JJ cord-283202-5fq1wxz8 434 2 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 434 3 in in IN cord-283202-5fq1wxz8 434 4 liver liver NN cord-283202-5fq1wxz8 434 5 cirrhosis cirrhosis NN cord-283202-5fq1wxz8 434 6 : : : cord-283202-5fq1wxz8 434 7 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 434 8 , , , cord-283202-5fq1wxz8 434 9 diagnosis diagnosis NN cord-283202-5fq1wxz8 434 10 and and CC cord-283202-5fq1wxz8 434 11 management management NN cord-283202-5fq1wxz8 434 12 Hepatic hepatic JJ cord-283202-5fq1wxz8 434 13 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 434 14 . . . cord-283202-5fq1wxz8 435 1 Current current JJ cord-283202-5fq1wxz8 435 2 concepts concept NNS cord-283202-5fq1wxz8 435 3 of of IN cord-283202-5fq1wxz8 435 4 the the DT cord-283202-5fq1wxz8 435 5 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 436 1 The the DT cord-283202-5fq1wxz8 436 2 dynamics dynamic NNS cord-283202-5fq1wxz8 436 3 of of IN cord-283202-5fq1wxz8 436 4 ammonia ammonia NN cord-283202-5fq1wxz8 436 5 metabolism metabolism NN cord-283202-5fq1wxz8 436 6 in in IN cord-283202-5fq1wxz8 436 7 man man NN cord-283202-5fq1wxz8 436 8 . . . cord-283202-5fq1wxz8 437 1 Effects effect NNS cord-283202-5fq1wxz8 437 2 of of IN cord-283202-5fq1wxz8 437 3 liver liver NN cord-283202-5fq1wxz8 437 4 disease disease NN cord-283202-5fq1wxz8 437 5 and and CC cord-283202-5fq1wxz8 437 6 hyperammonemia hyperammonemia NN cord-283202-5fq1wxz8 437 7 Hepatic hepatic JJ cord-283202-5fq1wxz8 437 8 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 437 9 : : : cord-283202-5fq1wxz8 437 10 molecular molecular JJ cord-283202-5fq1wxz8 437 11 mechanisms mechanism NNS cord-283202-5fq1wxz8 437 12 underlying underlie VBG cord-283202-5fq1wxz8 437 13 the the DT cord-283202-5fq1wxz8 437 14 clinical clinical JJ cord-283202-5fq1wxz8 437 15 syndrome syndrome NN cord-283202-5fq1wxz8 437 16 Metabolic metabolic JJ cord-283202-5fq1wxz8 437 17 compartments compartment NNS cord-283202-5fq1wxz8 437 18 in in IN cord-283202-5fq1wxz8 437 19 vivo vivo NN cord-283202-5fq1wxz8 437 20 . . . cord-283202-5fq1wxz8 438 1 Ammonia ammonia NN cord-283202-5fq1wxz8 438 2 and and CC cord-283202-5fq1wxz8 438 3 glutamic glutamic NN cord-283202-5fq1wxz8 438 4 acid acid NN cord-283202-5fq1wxz8 438 5 metabolism metabolism NN cord-283202-5fq1wxz8 438 6 in in IN cord-283202-5fq1wxz8 438 7 brain brain NN cord-283202-5fq1wxz8 438 8 and and CC cord-283202-5fq1wxz8 438 9 liver liver NN cord-283202-5fq1wxz8 438 10 Spongy Spongy NNP cord-283202-5fq1wxz8 438 11 degeneration degeneration NN cord-283202-5fq1wxz8 438 12 in in IN cord-283202-5fq1wxz8 438 13 the the DT cord-283202-5fq1wxz8 438 14 central central JJ cord-283202-5fq1wxz8 438 15 nervous nervous JJ cord-283202-5fq1wxz8 438 16 system system NN cord-283202-5fq1wxz8 438 17 of of IN cord-283202-5fq1wxz8 438 18 domestic domestic JJ cord-283202-5fq1wxz8 438 19 animals animal NNS cord-283202-5fq1wxz8 438 20 . . . cord-283202-5fq1wxz8 439 1 Part part NN cord-283202-5fq1wxz8 439 2 III iii CD cord-283202-5fq1wxz8 439 3 : : : cord-283202-5fq1wxz8 440 1 Occurrence occurrence NN cord-283202-5fq1wxz8 440 2 and and CC cord-283202-5fq1wxz8 440 3 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 440 4 of of IN cord-283202-5fq1wxz8 440 5 hepatocerebral hepatocerebral JJ cord-283202-5fq1wxz8 440 6 disease disease NN cord-283202-5fq1wxz8 440 7 caused cause VBN cord-283202-5fq1wxz8 440 8 by by IN cord-283202-5fq1wxz8 440 9 hyperammonaemia hyperammonaemia NN cord-283202-5fq1wxz8 440 10 Synergism synergism NN cord-283202-5fq1wxz8 440 11 between between IN cord-283202-5fq1wxz8 440 12 mercaptans mercaptan NNS cord-283202-5fq1wxz8 440 13 and and CC cord-283202-5fq1wxz8 440 14 ammonia ammonia NN cord-283202-5fq1wxz8 440 15 or or CC cord-283202-5fq1wxz8 440 16 fatty fatty JJ cord-283202-5fq1wxz8 440 17 acids acid NNS cord-283202-5fq1wxz8 440 18 in in IN cord-283202-5fq1wxz8 440 19 the the DT cord-283202-5fq1wxz8 440 20 production production NN cord-283202-5fq1wxz8 440 21 of of IN cord-283202-5fq1wxz8 440 22 coma coma NN cord-283202-5fq1wxz8 440 23 : : : cord-283202-5fq1wxz8 440 24 a a DT cord-283202-5fq1wxz8 440 25 possible possible JJ cord-283202-5fq1wxz8 440 26 role role NN cord-283202-5fq1wxz8 440 27 for for IN cord-283202-5fq1wxz8 440 28 mercaptans mercaptan NNS cord-283202-5fq1wxz8 440 29 in in IN cord-283202-5fq1wxz8 440 30 the the DT cord-283202-5fq1wxz8 440 31 pathogenesis pathogenesis NN cord-283202-5fq1wxz8 440 32 of of IN cord-283202-5fq1wxz8 440 33 hepatic hepatic JJ cord-283202-5fq1wxz8 440 34 coma coma NN cord-283202-5fq1wxz8 440 35 Experimental experimental JJ cord-283202-5fq1wxz8 440 36 hepatic hepatic JJ cord-283202-5fq1wxz8 440 37 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 440 38 : : : cord-283202-5fq1wxz8 440 39 changes change NNS cord-283202-5fq1wxz8 440 40 in in IN cord-283202-5fq1wxz8 440 41 the the DT cord-283202-5fq1wxz8 440 42 binding binding NN cord-283202-5fq1wxz8 440 43 of of IN cord-283202-5fq1wxz8 440 44 gamma gamma NN cord-283202-5fq1wxz8 440 45 - - HYPH cord-283202-5fq1wxz8 440 46 aminobutyric aminobutyric NN cord-283202-5fq1wxz8 440 47 acid acid NN cord-283202-5fq1wxz8 440 48 Hyperammonaemia Hyperammonaemia NNP cord-283202-5fq1wxz8 440 49 , , , cord-283202-5fq1wxz8 440 50 plasma plasma NN cord-283202-5fq1wxz8 440 51 aminoacid aminoacid JJ cord-283202-5fq1wxz8 440 52 imbalance imbalance NN cord-283202-5fq1wxz8 440 53 , , , cord-283202-5fq1wxz8 440 54 and and CC cord-283202-5fq1wxz8 440 55 blood blood NN cord-283202-5fq1wxz8 440 56 - - HYPH cord-283202-5fq1wxz8 440 57 brain brain NN cord-283202-5fq1wxz8 440 58 aminoacid aminoacid JJ cord-283202-5fq1wxz8 440 59 transport transport NN cord-283202-5fq1wxz8 440 60 : : : cord-283202-5fq1wxz8 440 61 a a DT cord-283202-5fq1wxz8 440 62 unified unified JJ cord-283202-5fq1wxz8 440 63 theory theory NN cord-283202-5fq1wxz8 440 64 of of IN cord-283202-5fq1wxz8 440 65 portal portal JJ cord-283202-5fq1wxz8 440 66 - - HYPH cord-283202-5fq1wxz8 440 67 systemic systemic JJ cord-283202-5fq1wxz8 440 68 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 440 69 Per per IN cord-283202-5fq1wxz8 440 70 rectal rectal JJ cord-283202-5fq1wxz8 440 71 portal portal NN cord-283202-5fq1wxz8 440 72 scintigraphy scintigraphy NN cord-283202-5fq1wxz8 440 73 using use VBG cord-283202-5fq1wxz8 440 74 99 99 CD cord-283202-5fq1wxz8 440 75 m m CD cord-283202-5fq1wxz8 440 76 technetium technetium NN cord-283202-5fq1wxz8 440 77 pertechnetate pertechnetate NN cord-283202-5fq1wxz8 440 78 to to TO cord-283202-5fq1wxz8 440 79 diagnose diagnose VB cord-283202-5fq1wxz8 440 80 portosystemic portosystemic JJ cord-283202-5fq1wxz8 440 81 shunts shunt NNS cord-283202-5fq1wxz8 440 82 in in IN cord-283202-5fq1wxz8 440 83 dogs dog NNS cord-283202-5fq1wxz8 440 84 and and CC cord-283202-5fq1wxz8 440 85 cats cat NNS cord-283202-5fq1wxz8 440 86 Diagnosis diagnosis NN cord-283202-5fq1wxz8 440 87 and and CC cord-283202-5fq1wxz8 440 88 treatment treatment NN cord-283202-5fq1wxz8 440 89 of of IN cord-283202-5fq1wxz8 440 90 portosystemic portosystemic JJ cord-283202-5fq1wxz8 440 91 shunts shunt NNS cord-283202-5fq1wxz8 440 92 in in IN cord-283202-5fq1wxz8 440 93 the the DT cord-283202-5fq1wxz8 440 94 cat cat NN cord-283202-5fq1wxz8 440 95 Ultrasonographic Ultrasonographic NNP cord-283202-5fq1wxz8 440 96 diagnosis diagnosis NN cord-283202-5fq1wxz8 440 97 of of IN cord-283202-5fq1wxz8 440 98 portosystemic portosystemic JJ cord-283202-5fq1wxz8 440 99 shunting shunt VBG cord-283202-5fq1wxz8 440 100 in in IN cord-283202-5fq1wxz8 440 101 dogs dog NNS cord-283202-5fq1wxz8 440 102 and and CC cord-283202-5fq1wxz8 440 103 cats cat NNS cord-283202-5fq1wxz8 440 104 Transcolonic Transcolonic NNP cord-283202-5fq1wxz8 440 105 sodium sodium NN cord-283202-5fq1wxz8 440 106 pertechnetate pertechnetate NNP cord-283202-5fq1wxz8 441 1 Tc Tc NNP cord-283202-5fq1wxz8 441 2 99 99 CD cord-283202-5fq1wxz8 441 3 m m NN cord-283202-5fq1wxz8 441 4 scintigraphy scintigraphy NN cord-283202-5fq1wxz8 441 5 for for IN cord-283202-5fq1wxz8 441 6 diagnosis diagnosis NN cord-283202-5fq1wxz8 441 7 of of IN cord-283202-5fq1wxz8 441 8 macrovascular macrovascular JJ cord-283202-5fq1wxz8 441 9 portosystemic portosystemic JJ cord-283202-5fq1wxz8 441 10 shunts shunt NNS cord-283202-5fq1wxz8 441 11 in in IN cord-283202-5fq1wxz8 441 12 dogs dog NNS cord-283202-5fq1wxz8 441 13 , , , cord-283202-5fq1wxz8 441 14 cats cat NNS cord-283202-5fq1wxz8 441 15 , , , cord-283202-5fq1wxz8 441 16 and and CC cord-283202-5fq1wxz8 441 17 potbellied potbellied JJ cord-283202-5fq1wxz8 441 18 pigs pig NNS cord-283202-5fq1wxz8 441 19 : : : cord-283202-5fq1wxz8 441 20 176 176 CD cord-283202-5fq1wxz8 441 21 cases case NNS cord-283202-5fq1wxz8 441 22 ( ( -LRB- cord-283202-5fq1wxz8 441 23 1988 1988 CD cord-283202-5fq1wxz8 441 24 - - SYM cord-283202-5fq1wxz8 441 25 1992 1992 CD cord-283202-5fq1wxz8 441 26 ) ) -RRB- cord-283202-5fq1wxz8 442 1 The the DT cord-283202-5fq1wxz8 442 2 treatment treatment NN cord-283202-5fq1wxz8 442 3 of of IN cord-283202-5fq1wxz8 442 4 hepatic hepatic JJ cord-283202-5fq1wxz8 442 5 encephalopathy encephalopathy NN cord-283202-5fq1wxz8 442 6 New new JJ cord-283202-5fq1wxz8 442 7 mode mode NN cord-283202-5fq1wxz8 442 8 of of IN cord-283202-5fq1wxz8 442 9 action action NN cord-283202-5fq1wxz8 442 10 for for IN cord-283202-5fq1wxz8 442 11 lactulose lactulose NN cord-283202-5fq1wxz8 442 12 Medical medical JJ cord-283202-5fq1wxz8 442 13 management management NN cord-283202-5fq1wxz8 442 14 of of IN cord-283202-5fq1wxz8 442 15 animals animal NNS cord-283202-5fq1wxz8 442 16 with with IN cord-283202-5fq1wxz8 442 17 portosystemic portosystemic JJ cord-283202-5fq1wxz8 442 18 shunts shunt NNS cord-283202-5fq1wxz8 442 19 Available available JJ cord-283202-5fq1wxz8 442 20 online online RB cord-283202-5fq1wxz8 442 21 at at IN cord-283202-5fq1wxz8 442 22 www.sciencedirect.com www.sciencedirect.com ADD