id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004911-fbge8tkc	Imrich, H.	On the role of peripheral macrophages during active experimental allergic encephalomyelitis (EAE)	2001		.txt	text/plain	6033	356	51	Severely and mildly diseased animals were analysed with respect to infiltration of T-cells, macrophages and upregulation of MHC class II molecules on microglia in the brain. Experimental allergic encephalomyelitis (EAE) is an inflammatory disease of the central nervous system (CNS) inducible in susceptible strains of rats by active immunisation with myelin basic protein (MBP) in adjuvant. To monitor such differences between diseased animals and animals without symptoms, leukocytes were isolated from the CNS and analysed by flow cytometry with regard to infiltrating T-cells (TCRϩ), macrophages (CD45 high ) and activation of resident microglia (CD45 low , MHC IIϩ). After immunisation of rats with MBP in CFA containing high dose of myc.T animals develop severe disease with high influx of T-cells and peripheral macrophages in brain tissue. After immunisation of rats with CFA containing low dose of myc.T, and constant concentrations of the autoantigen MBP animals failed to develop severe symptoms, nevertheless, they showed strong T-cell influx in brain parenchyma.	./cache/cord-004911-fbge8tkc.txt	./txt/cord-004911-fbge8tkc.txt