id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010187-ymhcfyxx	Gromeier, Matthias	Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis	2005-03-25		.txt	text/plain	5144	296	42	We report a comparison of the clinical course and the histopathological features of neurological disease resulting from intracerebral virus inoculation in normal micewith those of murine poliomyelitis in hPVR-tg mice. Histopathological analysis showed a diffuse encephalomyelitis induced by specific poliovirus serotype 2 isolates in normal mice, that affected neuronal cell populations without discrimination, whereas in hPVR-tg animals, damage was restricted to spinal motor neurons. 6 The hPVR is a highly glycosylated protein with an apparent molecular weight of 80kDa2 The animal model for poliomyelitis in hPVR-tg mice showed PV-induced damage of comparable anatomical distribution as in primates, 1°'11 an observation confirming views of the hPVR as the critical determinant conferring PV susceptibility. None of the normal mice injected with PVI(M) showed clinical signs of neurological damage, whereas inoculation of type 2 PV strains produced signs of CNS infection ( Table 2) .	./cache/cord-010187-ymhcfyxx.txt	./txt/cord-010187-ymhcfyxx.txt