id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017917-7aeh6quc	Marten, Norman W.	The Role of Metalloproteinases in Corona Virus Infection	2005		.txt	text/plain	3000	148	38	A number of MMPs and TIMPs have also been associated with the CNS inflammatory/demyelinating disease multiple sclerosis (MS) in humans (2,32) as well as its rodent model experimental autoimmune encephalitis (EAE) (10,38). The consistent association of MMP and TIMP expression with inflammatory demyelinating disease suggests that MMPs play either a direct or indirect role in promoting CNS pathology (2,27,32). However, subsequent analysis of individual cell populations sorted from infected brains indicated that MMP-9 gene expression is up regulated several fold among infiltrating inflammatory cells (Zhou, unpublished data) (Table 1) . Thus, MMP-9 from neutrophils is regulated at the level of degranulation as opposed to gene transcription and co-expression of TIMPs. These data suggest MMP-9 is likely released from both mononuclear and polymorphonuclear infiltrates during JHMV infection. Cell surface binding and activation of gelatinase A induced by expression of membrane-type-l-matrix metalloproteinase (MT1-MMP)	./cache/cord-017917-7aeh6quc.txt	./txt/cord-017917-7aeh6quc.txt