id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018042-qt7055fw	Müller, Marcus	Chemokine Actions in the CNS: Insights from Transgenic Mice	2008		.txt	text/plain	5804	268	42	So while constitutive, astrocyte-targeted production of CXCL10 can promote the recruitment of leukocytes to the CNS, this chemokine lacks the ability to further influence these cells, in particular, to drive a functional immune response. Although it has been possible to produce stimulus-evoked encephalopathy in MBP-and GFAP-CCL2 transgenic mice by systemic innate immune challenge these disorders are largely transient and therefore do not model the increased levels of CNS CCL2 that have been reported to occur in chronic neurological diseases such as human immunodeficiency virus type 1-associated dementia, amyotrophic lateral sclerosis, and multiple sclerosis. It is speculated that CCL21 derived from transgenic oligodendrocytes in the brain of the MBP-CCL21 mice may have interacted with CXCR3 on microglia inducing an inflammatory response that led to the influx of inflammatory cells into the CNS. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis	./cache/cord-018042-qt7055fw.txt	./txt/cord-018042-qt7055fw.txt