id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269861-r07osd0w	Kim, Jin Hyoung	CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4(+)Foxp3(+) T and IL-17(+)CD4(+) Th17 cells	2016-07-20		.txt	text/plain	12067	720	60	Our results also revealed that adoptive transfer of sorted CCR5(+)CD4(+)Foxp3(+) Tregs into Ccr5(−/−) mice could ameliorate JE progression without apparently altering the viral burden and CNS infiltration of IL-17(+)CD4(+) Th17 cells, myeloid-derived Ly-6C(hi) monocytes and Ly-6G(hi) granulocytes. The frequency and absolute number of CD4 + Foxp3 + Tregs (a, c), IFN-γ + CD4 + Th1, and IL-17 + CD4 + Th17 cells (b, d) in the spleen (a, b) and brain (c, d) of Ccr5 +/+ and Ccr5 −/− mice were determined by flow cytometric analysis at 3 and 5 days following JEV (3.0 × 10 7 pfu) infection. Although our results suggest that the increased number of CD4 + Foxp3 + Tregs in extraneural lymphoid tissue and the CNS of Ccr5 +/+ mice is associated with mild JE, we did not provide direct evidence regarding whether the enhanced response of CD4 + Foxp3 + Tregs plays a beneficial role in JE progression.	./cache/cord-269861-r07osd0w.txt	./txt/cord-269861-r07osd0w.txt