id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311845-wnk7itha	Lubetzki, Catherine	Demyelination in multiple sclerosis	2014-02-05		.txt	text/plain	7400	345	37	Whereas multiple sclerosis was long considered as a T cell-mediated disease, the role of B lymphocytes is now increasingly recognized, and the influence of antibodies on tissue damage actively investigated. Multiple sclerosis (MS) is generally considered as an autoimmune disease, in which autoreactive T cells enter the central nervous system (CNS) from the peripheral circulation and induce an inflammatory cascade resulting in demyelination and axonal loss. Nevertheless, vesicular disruption of myelin seen in highly active MS lesions was found to be associated with anti-MOG and MBP antibodies, suggesting that demyelination might be causally related to the deposition of antigen-specific autoantibodies (Genain et al., 1999) . Recent findings have suggested that, following a primary oligodendrocyte or myelin injury, local APCs could process myelin antigens and traffic from the CNS to secondary lymphoid organs, where they may induce or enhance an adaptive demyelinating immune reaction.	./cache/cord-311845-wnk7itha.txt	./txt/cord-311845-wnk7itha.txt