id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330553-sukrjl22	Stonedahl, Sarah	The Role of Microglia during West Nile Virus Infection of the Central Nervous System	2020-08-28		.txt	text/plain	5545	283	41	WNV infection also induces neuroinflammation characterized by activation of innate immune cells, including microglia and astrocytes, production of inflammatory cytokines, breakdown of the blood-brain barrier, and infiltration of peripheral leukocytes. In this review, we will discuss the role of microglia in WNV-induced CNS disease as a contributor both to the protective innate immune response and to the development of long-term neurological damage. Inhibition of these chemokines/cytokines following treatment with minocycline resulted in decreased neuronal cell death following WNV infection of ex vivo spinal cord slice cultures [42] , suggesting they contribute to disease; however, depletion of microglia did not significantly change chemokine/cytokine expression in the brains of WNV-infected mice [60] so it is unclear what role microglia play in the production of these proteins. Death Receptor-Mediated Apoptotic Signaling Is Activated in the Brain following Infection with West Nile Virus in the Absence of a Peripheral Immune Response	./cache/cord-330553-sukrjl22.txt	./txt/cord-330553-sukrjl22.txt