id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334577-wb6zhovi	Mangale, Vrushali	Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system	2020-05-25		.txt	text/plain	5118	245	43	Treatment with PLX5622, an inhibitor of colony stimulating factor 1 receptor (CSF1R) that efficiently depletes microglia, prior to infection of the central nervous system (CNS) with the neurotropic JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality compared with control mice that correlated with impaired control of viral replication. tor 1 receptor (CSF1R) that efficiently depletes microglia, prior to infection of the central nervous system (CNS) with the neurotropic JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality compared with control mice that correlated with impaired control of viral replication. Our findings emphasize an important role for microglia in aiding in host defense in response to JHMV infection of the CNS as well as influencing both the severity of spinal cord demyelination and remyelination in a model of murine coronavirus-induced neurologic disease.	./cache/cord-334577-wb6zhovi.txt	./txt/cord-334577-wb6zhovi.txt