id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348746-yaf61cmx	Foley, Janet E.	A Review of Coronavirus Infection in the Central Nervous System of Cats and Mice	2008-06-28		.txt	text/plain	5478	323	37	F eline infectious peritonitis (FIP) is a fatal, immune-mediated disease produced as a result of infection of macrophages by mutant feline coronavirus strains (FIPVs). In acute MHV-A59 infection in CD8ϩ T-cell deficient mice, periventricular encephalitis occurs with lymphocytic infiltration into the choroid plexus, ependyma, and subependymal brain tissue. Depending on mouse strain and immunological status, MHV-JHM produces meningeal inflammation associated with T-cells and macrophages and demyelination but relatively little disease in axons. If mice are pretreated with passive infusions of antibodies or T-cells or if they receive neuroattenuated MHV strains, they develop chronic, but not fatal, disease after MHV-JHM infection. 62, 63 Immunocompetent C57BL/6 mice clear MHV-JHM virus from the brain but develop severe immune-mediated demyelination and paralysis. Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus	./cache/cord-348746-yaf61cmx.txt	./txt/cord-348746-yaf61cmx.txt