id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355413-ls2nud43	Shi, Fu-Dong	Nature killer cells in the central nervous system	2010-01-29		.txt	text/plain	6858	345	45	The pathogenic mechanism observed appeared to represent a novel type of autoimmune reaction: an exogenously/chemically induced alteration in a specific subset of cells that was suggested to target them for direct NK cell-mediated killing. The migration of NK cells to the CNS during inflammatory responses and lack of inhibitory signal MHC class I expression within the CNS invites prediction that direct cytolytic effects of NK cells contribute to oligodendrocyte damage and demyelination to CNS diseases such as MS. Intracerebral infection of RAG1 / mice with a recombinant CXCL10-expressing murine coronavirus (MHV) resulted in protection from disease and increased survival that correlated with a significant increase in recruitment and activation of NK cells within the CNS (Walsh et al., 2007) . Associated with decreased resistance to viral infection, CCR5 / mice yielded significantly more virus and expressed higher levels of tumour necrosis factor alpha (TNF-), CXCL1, CCL2, CCL3 and CCL5 in the vagina, spinal cord, and/or brain stem than did wild-type mice.	./cache/cord-355413-ls2nud43.txt	./txt/cord-355413-ls2nud43.txt