id sid tid token lemma pos cord-005146-o3roa7br 1 1 key key JJ cord-005146-o3roa7br 2 1 : : : cord-005146-o3roa7br 2 2 cord-005146-o3roa7br cord-005146-o3roa7br NNP cord-005146-o3roa7br 2 3 authors author NNS cord-005146-o3roa7br 2 4 : : : cord-005146-o3roa7br 2 5 Sasaki Sasaki NNP cord-005146-o3roa7br 2 6 , , , cord-005146-o3roa7br 2 7 Makoto Makoto NNP cord-005146-o3roa7br 2 8 ; ; : cord-005146-o3roa7br 2 9 Ide Ide NNP cord-005146-o3roa7br 2 10 , , , cord-005146-o3roa7br 2 11 Chizuka Chizuka NNP cord-005146-o3roa7br 2 12 title title NN cord-005146-o3roa7br 2 13 : : : cord-005146-o3roa7br 2 14 Demyelination Demyelination NNP cord-005146-o3roa7br 2 15 and and CC cord-005146-o3roa7br 2 16 remyelination remyelination NN cord-005146-o3roa7br 2 17 in in IN cord-005146-o3roa7br 2 18 the the DT cord-005146-o3roa7br 2 19 dorsal dorsal JJ cord-005146-o3roa7br 2 20 funiculus funiculu NNS cord-005146-o3roa7br 2 21 of of IN cord-005146-o3roa7br 2 22 the the DT cord-005146-o3roa7br 2 23 rat rat NN cord-005146-o3roa7br 2 24 spinal spinal JJ cord-005146-o3roa7br 2 25 cord cord NN cord-005146-o3roa7br 2 26 after after IN cord-005146-o3roa7br 2 27 heat heat NN cord-005146-o3roa7br 2 28 injury injury NN cord-005146-o3roa7br 2 29 date date NN cord-005146-o3roa7br 2 30 : : : cord-005146-o3roa7br 2 31 1989 1989 CD cord-005146-o3roa7br 2 32 journal journal NNP cord-005146-o3roa7br 2 33 : : : cord-005146-o3roa7br 3 1 J J NNP cord-005146-o3roa7br 3 2 Neurocytol Neurocytol NNP cord-005146-o3roa7br 3 3 DOI DOI NNP cord-005146-o3roa7br 3 4 : : : cord-005146-o3roa7br 4 1 10.1007 10.1007 CD cord-005146-o3roa7br 4 2 / / SYM cord-005146-o3roa7br 4 3 bf01206664 bf01206664 NNP cord-005146-o3roa7br 4 4 sha sha NNP cord-005146-o3roa7br 4 5 : : : cord-005146-o3roa7br 4 6 2de8a8e4d7692a61cd0389c5488b8c301ccbf7a5 2de8a8e4d7692a61cd0389c5488b8c301ccbf7a5 CD cord-005146-o3roa7br 4 7 doc_id doc_id CD cord-005146-o3roa7br 4 8 : : : cord-005146-o3roa7br 4 9 5146 5146 CD cord-005146-o3roa7br 4 10 cord_uid cord_uid NNS cord-005146-o3roa7br 4 11 : : : cord-005146-o3roa7br 5 1 o3roa7br o3roa7br `` cord-005146-o3roa7br 5 2 Part part NN cord-005146-o3roa7br 5 3 of of IN cord-005146-o3roa7br 5 4 the the DT cord-005146-o3roa7br 5 5 dorsal dorsal JJ cord-005146-o3roa7br 5 6 funiculus funiculu NNS cord-005146-o3roa7br 5 7 of of IN cord-005146-o3roa7br 5 8 the the DT cord-005146-o3roa7br 5 9 adult adult NN cord-005146-o3roa7br 5 10 male male JJ cord-005146-o3roa7br 5 11 rat rat NN cord-005146-o3roa7br 5 12 ( ( -LRB- cord-005146-o3roa7br 5 13 Wistar Wistar NNP cord-005146-o3roa7br 5 14 ) ) -RRB- cord-005146-o3roa7br 5 15 spinal spinal JJ cord-005146-o3roa7br 5 16 cord cord NN cord-005146-o3roa7br 5 17 was be VBD cord-005146-o3roa7br 5 18 treated treat VBN cord-005146-o3roa7br 5 19 for for IN cord-005146-o3roa7br 5 20 l l NNP cord-005146-o3roa7br 5 21 h h NNP cord-005146-o3roa7br 5 22 at at IN cord-005146-o3roa7br 5 23 the the DT cord-005146-o3roa7br 5 24 thoracolumbar thoracolumbar NN cord-005146-o3roa7br 5 25 level level NN cord-005146-o3roa7br 5 26 by by IN cord-005146-o3roa7br 5 27 running run VBG cord-005146-o3roa7br 5 28 hot hot JJ cord-005146-o3roa7br 5 29 water water NN cord-005146-o3roa7br 5 30 , , , cord-005146-o3roa7br 5 31 at at IN cord-005146-o3roa7br 5 32 approximately approximately RB cord-005146-o3roa7br 5 33 48–50 48–50 CD cord-005146-o3roa7br 5 34 ° ° NN cord-005146-o3roa7br 5 35 C C NNP cord-005146-o3roa7br 5 36 , , , cord-005146-o3roa7br 5 37 through through IN cord-005146-o3roa7br 5 38 a a DT cord-005146-o3roa7br 5 39 polyethylene polyethylene NN cord-005146-o3roa7br 5 40 tube tube NN cord-005146-o3roa7br 5 41 2 2 CD cord-005146-o3roa7br 5 42 mm mm NN cord-005146-o3roa7br 5 43 in in IN cord-005146-o3roa7br 5 44 diameter diameter NN cord-005146-o3roa7br 5 45 in in IN cord-005146-o3roa7br 5 46 contact contact NN cord-005146-o3roa7br 5 47 with with IN cord-005146-o3roa7br 5 48 the the DT cord-005146-o3roa7br 5 49 dura dura NN cord-005146-o3roa7br 5 50 . . . cord-005146-o3roa7br 6 1 Animals animal NNS cord-005146-o3roa7br 6 2 were be VBD cord-005146-o3roa7br 6 3 fixed fix VBN cord-005146-o3roa7br 6 4 1 1 CD cord-005146-o3roa7br 6 5 day day NN cord-005146-o3roa7br 6 6 to to IN cord-005146-o3roa7br 6 7 4 4 CD cord-005146-o3roa7br 6 8 weeks week NNS cord-005146-o3roa7br 6 9 later later RB cord-005146-o3roa7br 6 10 and and CC cord-005146-o3roa7br 6 11 the the DT cord-005146-o3roa7br 6 12 spinal spinal JJ cord-005146-o3roa7br 6 13 cords cord NNS cord-005146-o3roa7br 6 14 were be VBD cord-005146-o3roa7br 6 15 examined examine VBN cord-005146-o3roa7br 6 16 by by IN cord-005146-o3roa7br 6 17 light light NN cord-005146-o3roa7br 6 18 and and CC cord-005146-o3roa7br 6 19 electron electron NN cord-005146-o3roa7br 6 20 microscopy microscopy NN cord-005146-o3roa7br 6 21 . . . cord-005146-o3roa7br 7 1 The the DT cord-005146-o3roa7br 7 2 affected affected JJ cord-005146-o3roa7br 7 3 area area NN cord-005146-o3roa7br 7 4 in in IN cord-005146-o3roa7br 7 5 the the DT cord-005146-o3roa7br 7 6 dorsal dorsal JJ cord-005146-o3roa7br 7 7 funiculus funiculus NNP cord-005146-o3roa7br 7 8 was be VBD cord-005146-o3roa7br 7 9 approximately approximately RB cord-005146-o3roa7br 7 10 1 1 CD cord-005146-o3roa7br 7 11 mm mm NN cord-005146-o3roa7br 7 12 long long RB cord-005146-o3roa7br 7 13 and and CC cord-005146-o3roa7br 7 14 less less JJR cord-005146-o3roa7br 7 15 than than IN cord-005146-o3roa7br 7 16 1 1 CD cord-005146-o3roa7br 7 17 mm mm NN cord-005146-o3roa7br 7 18 wide wide JJ cord-005146-o3roa7br 7 19 at at IN cord-005146-o3roa7br 7 20 the the DT cord-005146-o3roa7br 7 21 dorsal dorsal JJ cord-005146-o3roa7br 7 22 surface surface NN cord-005146-o3roa7br 7 23 , , , cord-005146-o3roa7br 7 24 and and CC cord-005146-o3roa7br 7 25 varied varied JJ cord-005146-o3roa7br 7 26 from from IN cord-005146-o3roa7br 7 27 0.4 0.4 CD cord-005146-o3roa7br 7 28 to to TO cord-005146-o3roa7br 7 29 0.7 0.7 CD cord-005146-o3roa7br 7 30 mm mm NNS cord-005146-o3roa7br 7 31 in in IN cord-005146-o3roa7br 7 32 depth depth NN cord-005146-o3roa7br 7 33 . . . cord-005146-o3roa7br 8 1 Within within IN cord-005146-o3roa7br 8 2 3 3 CD cord-005146-o3roa7br 8 3 days day NNS cord-005146-o3roa7br 8 4 after after IN cord-005146-o3roa7br 8 5 treatment treatment NN cord-005146-o3roa7br 8 6 , , , cord-005146-o3roa7br 8 7 almost almost RB cord-005146-o3roa7br 8 8 all all PDT cord-005146-o3roa7br 8 9 the the DT cord-005146-o3roa7br 8 10 myelin myelin JJ cord-005146-o3roa7br 8 11 sheaths sheath NNS cord-005146-o3roa7br 8 12 in in IN cord-005146-o3roa7br 8 13 the the DT cord-005146-o3roa7br 8 14 affected affected JJ cord-005146-o3roa7br 8 15 area area NN cord-005146-o3roa7br 8 16 were be VBD cord-005146-o3roa7br 8 17 degraded degrade VBN cord-005146-o3roa7br 8 18 , , , cord-005146-o3roa7br 8 19 leaving leave VBG cord-005146-o3roa7br 8 20 the the DT cord-005146-o3roa7br 8 21 axons axon NNS cord-005146-o3roa7br 8 22 denuded denude VBN cord-005146-o3roa7br 8 23 , , , cord-005146-o3roa7br 8 24 and and CC cord-005146-o3roa7br 8 25 at at IN cord-005146-o3roa7br 8 26 the the DT cord-005146-o3roa7br 8 27 same same JJ cord-005146-o3roa7br 8 28 time time NN cord-005146-o3roa7br 8 29 astrocyte astrocyte NNP cord-005146-o3roa7br 8 30 endfeet endfeet NNP cord-005146-o3roa7br 8 31 at at IN cord-005146-o3roa7br 8 32 the the DT cord-005146-o3roa7br 8 33 glial glial JJ cord-005146-o3roa7br 8 34 limiting limit VBG cord-005146-o3roa7br 8 35 membrane membrane NN cord-005146-o3roa7br 8 36 were be VBD cord-005146-o3roa7br 8 37 swollen swollen JJ cord-005146-o3roa7br 8 38 and and CC cord-005146-o3roa7br 8 39 partly partly RB cord-005146-o3roa7br 8 40 destroyed destroy VBN cord-005146-o3roa7br 8 41 . . . cord-005146-o3roa7br 9 1 Almost almost RB cord-005146-o3roa7br 9 2 all all PDT cord-005146-o3roa7br 9 3 the the DT cord-005146-o3roa7br 9 4 denuded denude VBN cord-005146-o3roa7br 9 5 axons axon NNS cord-005146-o3roa7br 9 6 remained remain VBD cord-005146-o3roa7br 9 7 intact intact JJ cord-005146-o3roa7br 9 8 , , , cord-005146-o3roa7br 9 9 exhibiting exhibit VBG cord-005146-o3roa7br 9 10 no no DT cord-005146-o3roa7br 9 11 noticeable noticeable JJ cord-005146-o3roa7br 9 12 morphological morphological JJ cord-005146-o3roa7br 9 13 changes change NNS cord-005146-o3roa7br 9 14 . . . cord-005146-o3roa7br 10 1 There there EX cord-005146-o3roa7br 10 2 was be VBD cord-005146-o3roa7br 10 3 evidence evidence NN cord-005146-o3roa7br 10 4 of of IN cord-005146-o3roa7br 10 5 a a DT cord-005146-o3roa7br 10 6 moderate moderate JJ cord-005146-o3roa7br 10 7 vasogenic vasogenic NN cord-005146-o3roa7br 10 8 oedema oedema NN cord-005146-o3roa7br 10 9 , , , cord-005146-o3roa7br 10 10 but but CC cord-005146-o3roa7br 10 11 minimal minimal JJ cord-005146-o3roa7br 10 12 signs sign NNS cord-005146-o3roa7br 10 13 of of IN cord-005146-o3roa7br 10 14 haemorrhage haemorrhage NN cord-005146-o3roa7br 10 15 in in IN cord-005146-o3roa7br 10 16 the the DT cord-005146-o3roa7br 10 17 lesion lesion NN cord-005146-o3roa7br 10 18 . . . cord-005146-o3roa7br 11 1 Seven seven CD cord-005146-o3roa7br 11 2 days day NNS cord-005146-o3roa7br 11 3 after after IN cord-005146-o3roa7br 11 4 treatment treatment NN cord-005146-o3roa7br 11 5 , , , cord-005146-o3roa7br 11 6 many many JJ cord-005146-o3roa7br 11 7 immature immature JJ cord-005146-o3roa7br 11 8 Schwann Schwann NNP cord-005146-o3roa7br 11 9 cells cell NNS cord-005146-o3roa7br 11 10 but but CC cord-005146-o3roa7br 11 11 no no DT cord-005146-o3roa7br 11 12 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 11 13 were be VBD cord-005146-o3roa7br 11 14 found find VBN cord-005146-o3roa7br 11 15 between between IN cord-005146-o3roa7br 11 16 the the DT cord-005146-o3roa7br 11 17 denuded denuded JJ cord-005146-o3roa7br 11 18 axons axon NNS cord-005146-o3roa7br 11 19 . . . cord-005146-o3roa7br 12 1 By by IN cord-005146-o3roa7br 12 2 2 2 CD cord-005146-o3roa7br 12 3 weeks week NNS cord-005146-o3roa7br 12 4 many many JJ cord-005146-o3roa7br 12 5 of of IN cord-005146-o3roa7br 12 6 the the DT cord-005146-o3roa7br 12 7 denuded denude VBN cord-005146-o3roa7br 12 8 axons axon NNS cord-005146-o3roa7br 12 9 were be VBD cord-005146-o3roa7br 12 10 remyelinated remyelinate VBN cord-005146-o3roa7br 12 11 , , , cord-005146-o3roa7br 12 12 and and CC cord-005146-o3roa7br 12 13 by by IN cord-005146-o3roa7br 12 14 4 4 CD cord-005146-o3roa7br 12 15 weeks week NNS cord-005146-o3roa7br 12 16 almost almost RB cord-005146-o3roa7br 12 17 all all DT cord-005146-o3roa7br 12 18 of of IN cord-005146-o3roa7br 12 19 those those DT cord-005146-o3roa7br 12 20 axons axon NNS cord-005146-o3roa7br 12 21 located locate VBN cord-005146-o3roa7br 12 22 near near IN cord-005146-o3roa7br 12 23 the the DT cord-005146-o3roa7br 12 24 pial pial JJ cord-005146-o3roa7br 12 25 and and CC cord-005146-o3roa7br 12 26 perivascular perivascular JJ cord-005146-o3roa7br 12 27 surfaces surface NNS cord-005146-o3roa7br 12 28 had have VBD cord-005146-o3roa7br 12 29 been be VBN cord-005146-o3roa7br 12 30 remyelinated remyelinate VBN cord-005146-o3roa7br 12 31 by by IN cord-005146-o3roa7br 12 32 Schwann Schwann NNP cord-005146-o3roa7br 12 33 cells cell NNS cord-005146-o3roa7br 12 34 , , , cord-005146-o3roa7br 12 35 while while IN cord-005146-o3roa7br 12 36 most most JJS cord-005146-o3roa7br 12 37 of of IN cord-005146-o3roa7br 12 38 those those DT cord-005146-o3roa7br 12 39 located locate VBN cord-005146-o3roa7br 12 40 in in IN cord-005146-o3roa7br 12 41 the the DT cord-005146-o3roa7br 12 42 deep deep JJ cord-005146-o3roa7br 12 43 and and CC cord-005146-o3roa7br 12 44 marginal marginal JJ cord-005146-o3roa7br 12 45 zones zone NNS cord-005146-o3roa7br 12 46 bordering border VBG cord-005146-o3roa7br 12 47 the the DT cord-005146-o3roa7br 12 48 adjoining adjoining JJ cord-005146-o3roa7br 12 49 intact intact JJ cord-005146-o3roa7br 12 50 areas area NNS cord-005146-o3roa7br 12 51 were be VBD cord-005146-o3roa7br 12 52 remyelinated remyelinate VBN cord-005146-o3roa7br 12 53 by by IN cord-005146-o3roa7br 12 54 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 12 55 . . . cord-005146-o3roa7br 13 1 Longitudinal longitudinal JJ cord-005146-o3roa7br 13 2 sections section NNS cord-005146-o3roa7br 13 3 revealed reveal VBD cord-005146-o3roa7br 13 4 that that IN cord-005146-o3roa7br 13 5 at at IN cord-005146-o3roa7br 13 6 nodes node NNS cord-005146-o3roa7br 13 7 of of IN cord-005146-o3roa7br 13 8 Ranvier Ranvier NNP cord-005146-o3roa7br 13 9 PNS PNS NNP cord-005146-o3roa7br 13 10 - - HYPH cord-005146-o3roa7br 13 11 type type NN cord-005146-o3roa7br 13 12 myelin myelin NN cord-005146-o3roa7br 13 13 sheaths sheath NNS cord-005146-o3roa7br 13 14 were be VBD cord-005146-o3roa7br 13 15 apposed appose VBN cord-005146-o3roa7br 13 16 by by IN cord-005146-o3roa7br 13 17 either either DT cord-005146-o3roa7br 13 18 intact intact JJ cord-005146-o3roa7br 13 19 or or CC cord-005146-o3roa7br 13 20 newly newly RB cord-005146-o3roa7br 13 21 formed form VBN cord-005146-o3roa7br 13 22 CNS CNS NNP cord-005146-o3roa7br 13 23 - - HYPH cord-005146-o3roa7br 13 24 type type NN cord-005146-o3roa7br 13 25 myelin myelin NN cord-005146-o3roa7br 13 26 sheaths sheath NNS cord-005146-o3roa7br 13 27 . . . cord-005146-o3roa7br 14 1 A a DT cord-005146-o3roa7br 14 2 typical typical JJ cord-005146-o3roa7br 14 3 glial glial NN cord-005146-o3roa7br 14 4 limiting limit VBG cord-005146-o3roa7br 14 5 membrane membrane NN cord-005146-o3roa7br 14 6 was be VBD cord-005146-o3roa7br 14 7 not not RB cord-005146-o3roa7br 14 8 reformed reform VBN cord-005146-o3roa7br 14 9 beneath beneath IN cord-005146-o3roa7br 14 10 the the DT cord-005146-o3roa7br 14 11 pial pial JJ cord-005146-o3roa7br 14 12 surface surface NN cord-005146-o3roa7br 14 13 , , , cord-005146-o3roa7br 14 14 but but CC cord-005146-o3roa7br 14 15 an an DT cord-005146-o3roa7br 14 16 inconspicuous inconspicuous JJ cord-005146-o3roa7br 14 17 one one NN cord-005146-o3roa7br 14 18 was be VBD cord-005146-o3roa7br 14 19 found find VBN cord-005146-o3roa7br 14 20 between between IN cord-005146-o3roa7br 14 21 the the DT cord-005146-o3roa7br 14 22 PNS- PNS- NNP cord-005146-o3roa7br 14 23 and and CC cord-005146-o3roa7br 14 24 CNS CNS NNP cord-005146-o3roa7br 14 25 - - HYPH cord-005146-o3roa7br 14 26 type type NN cord-005146-o3roa7br 14 27 fibre fibre NN cord-005146-o3roa7br 14 28 areas area NNS cord-005146-o3roa7br 14 29 . . . cord-005146-o3roa7br 15 1 Recently recently RB cord-005146-o3roa7br 15 2 , , , cord-005146-o3roa7br 15 3 therapeutic therapeutic JJ cord-005146-o3roa7br 15 4 hyperthermia hyperthermia NN cord-005146-o3roa7br 15 5 in in IN cord-005146-o3roa7br 15 6 localized localized JJ cord-005146-o3roa7br 15 7 or or CC cord-005146-o3roa7br 15 8 whole whole JJ cord-005146-o3roa7br 15 9 - - HYPH cord-005146-o3roa7br 15 10 body body NN cord-005146-o3roa7br 15 11 applications application NNS cord-005146-o3roa7br 15 12 has have VBZ cord-005146-o3roa7br 15 13 been be VBN cord-005146-o3roa7br 15 14 used use VBN cord-005146-o3roa7br 15 15 as as IN cord-005146-o3roa7br 15 16 a a DT cord-005146-o3roa7br 15 17 new new JJ cord-005146-o3roa7br 15 18 method method NN cord-005146-o3roa7br 15 19 of of IN cord-005146-o3roa7br 15 20 cancer cancer NN cord-005146-o3roa7br 15 21 therapy therapy NN cord-005146-o3roa7br 15 22 . . . cord-005146-o3roa7br 16 1 In in IN cord-005146-o3roa7br 16 2 focal focal JJ cord-005146-o3roa7br 16 3 hyperthermia hyperthermia NN cord-005146-o3roa7br 16 4 , , , cord-005146-o3roa7br 16 5 the the DT cord-005146-o3roa7br 16 6 tissue tissue NN cord-005146-o3roa7br 16 7 is be VBZ cord-005146-o3roa7br 16 8 heated heat VBN cord-005146-o3roa7br 16 9 with with IN cord-005146-o3roa7br 16 10 microwave microwave NN cord-005146-o3roa7br 16 11 or or CC cord-005146-o3roa7br 16 12 ultrasound ultrasound NN cord-005146-o3roa7br 16 13 transducers transducer NNS cord-005146-o3roa7br 16 14 to to IN cord-005146-o3roa7br 16 15 about about RB cord-005146-o3roa7br 16 16 40 40 CD cord-005146-o3roa7br 16 17 ~ ~ CD cord-005146-o3roa7br 16 18 C C NNP cord-005146-o3roa7br 16 19 , , , cord-005146-o3roa7br 16 20 a a DT cord-005146-o3roa7br 16 21 temperature temperature NN cord-005146-o3roa7br 16 22 which which WDT cord-005146-o3roa7br 16 23 damages damage VBZ cord-005146-o3roa7br 16 24 tumour tumour NN cord-005146-o3roa7br 16 25 cells cell NNS cord-005146-o3roa7br 16 26 but but CC cord-005146-o3roa7br 16 27 does do VBZ cord-005146-o3roa7br 16 28 not not RB cord-005146-o3roa7br 16 29 affect affect VB cord-005146-o3roa7br 16 30 the the DT cord-005146-o3roa7br 16 31 surrounding surround VBG cord-005146-o3roa7br 16 32 normal normal JJ cord-005146-o3roa7br 16 33 tissue tissue NN cord-005146-o3roa7br 16 34 ( ( -LRB- cord-005146-o3roa7br 16 35 Hahn Hahn NNP cord-005146-o3roa7br 16 36 , , , cord-005146-o3roa7br 16 37 1982 1982 CD cord-005146-o3roa7br 16 38 ) ) -RRB- cord-005146-o3roa7br 16 39 . . . cord-005146-o3roa7br 17 1 Changes change NNS cord-005146-o3roa7br 17 2 in in IN cord-005146-o3roa7br 17 3 the the DT cord-005146-o3roa7br 17 4 normal normal JJ cord-005146-o3roa7br 17 5 brain brain NN cord-005146-o3roa7br 17 6 and and CC cord-005146-o3roa7br 17 7 spinal spinal JJ cord-005146-o3roa7br 17 8 cord cord NN cord-005146-o3roa7br 17 9 tissues tissue NNS cord-005146-o3roa7br 17 10 resulting result VBG cord-005146-o3roa7br 17 11 as as IN cord-005146-o3roa7br 17 12 an an DT cord-005146-o3roa7br 17 13 adverse adverse JJ cord-005146-o3roa7br 17 14 effect effect NN cord-005146-o3roa7br 17 15 of of IN cord-005146-o3roa7br 17 16 clinical clinical JJ cord-005146-o3roa7br 17 17 or or CC cord-005146-o3roa7br 17 18 experimental experimental JJ cord-005146-o3roa7br 17 19 hyperthermia hyperthermia NN cord-005146-o3roa7br 17 20 have have VBP cord-005146-o3roa7br 17 21 been be VBN cord-005146-o3roa7br 17 22 studied study VBN cord-005146-o3roa7br 17 23 only only RB cord-005146-o3roa7br 17 24 sporadically sporadically RB cord-005146-o3roa7br 17 25 in in IN cord-005146-o3roa7br 17 26 the the DT cord-005146-o3roa7br 17 27 past past JJ cord-005146-o3roa7br 17 28 three three CD cord-005146-o3roa7br 17 29 decades decade NNS cord-005146-o3roa7br 18 1 ( ( -LRB- cord-005146-o3roa7br 18 2 Barnard Barnard NNP cord-005146-o3roa7br 18 3 et et NNP cord-005146-o3roa7br 18 4 al al NNP cord-005146-o3roa7br 18 5 . . NNP cord-005146-o3roa7br 18 6 , , , cord-005146-o3roa7br 18 7 1956 1956 CD cord-005146-o3roa7br 18 8 ; ; : cord-005146-o3roa7br 18 9 Fajardo Fajardo NNP cord-005146-o3roa7br 18 10 , , , cord-005146-o3roa7br 18 11 1984 1984 CD cord-005146-o3roa7br 18 12 ; ; . cord-005146-o3roa7br 19 1 Lyons Lyons NNP cord-005146-o3roa7br 19 2 et et NNP cord-005146-o3roa7br 19 3 al al NNP cord-005146-o3roa7br 19 4 . . NNP cord-005146-o3roa7br 19 5 , , , cord-005146-o3roa7br 19 6 1986 1986 CD cord-005146-o3roa7br 19 7 ) ) -RRB- cord-005146-o3roa7br 19 8 . . . cord-005146-o3roa7br 20 1 In in IN cord-005146-o3roa7br 20 2 a a DT cord-005146-o3roa7br 20 3 clinical clinical JJ cord-005146-o3roa7br 20 4 study study NN cord-005146-o3roa7br 20 5 ( ( -LRB- cord-005146-o3roa7br 20 6 Douglas Douglas NNP cord-005146-o3roa7br 20 7 et et NNP cord-005146-o3roa7br 20 8 al al NNP cord-005146-o3roa7br 20 9 . . NNP cord-005146-o3roa7br 20 10 , , , cord-005146-o3roa7br 20 11 1981 1981 CD cord-005146-o3roa7br 20 12 ) ) -RRB- cord-005146-o3roa7br 20 13 on on IN cord-005146-o3roa7br 20 14 the the DT cord-005146-o3roa7br 20 15 myelopathy myelopathy NN cord-005146-o3roa7br 20 16 induced induce VBN cord-005146-o3roa7br 20 17 by by IN cord-005146-o3roa7br 20 18 whole whole JJ cord-005146-o3roa7br 20 19 - - HYPH cord-005146-o3roa7br 20 20 body body NN cord-005146-o3roa7br 20 21 hyperthermia hyperthermia NN cord-005146-o3roa7br 20 22 at at IN cord-005146-o3roa7br 20 23 41.8~ 41.8~ CD cord-005146-o3roa7br 20 24 for for IN cord-005146-o3roa7br 20 25 6h 6h CD cord-005146-o3roa7br 20 26 , , , cord-005146-o3roa7br 20 27 severe severe JJ cord-005146-o3roa7br 20 28 demyelination demyelination NN cord-005146-o3roa7br 20 29 , , , cord-005146-o3roa7br 20 30 axonal axonal JJ cord-005146-o3roa7br 20 31 and and CC cord-005146-o3roa7br 20 32 gliaI gliai NN cord-005146-o3roa7br 20 33 cell cell NN cord-005146-o3roa7br 20 34 degeneration degeneration NN cord-005146-o3roa7br 20 35 , , , cord-005146-o3roa7br 20 36 and and CC cord-005146-o3roa7br 20 37 vascular vascular JJ cord-005146-o3roa7br 20 38 congestion congestion NN cord-005146-o3roa7br 20 39 were be VBD cord-005146-o3roa7br 20 40 noted note VBN cord-005146-o3roa7br 20 41 to to TO cord-005146-o3roa7br 20 42 occur occur VB cord-005146-o3roa7br 20 43 in in IN cord-005146-o3roa7br 20 44 the the DT cord-005146-o3roa7br 20 45 white white JJ cord-005146-o3roa7br 20 46 matter matter NN cord-005146-o3roa7br 20 47 ; ; : cord-005146-o3roa7br 20 48 and and CC cord-005146-o3roa7br 20 49 swelling swelling NN cord-005146-o3roa7br 20 50 and and CC cord-005146-o3roa7br 20 51 chromatolysis chromatolysis NN cord-005146-o3roa7br 20 52 of of IN cord-005146-o3roa7br 20 53 the the DT cord-005146-o3roa7br 20 54 neurons neuron NNS cord-005146-o3roa7br 20 55 were be VBD cord-005146-o3roa7br 20 56 seen see VBN cord-005146-o3roa7br 20 57 in in IN cord-005146-o3roa7br 20 58 the the DT cord-005146-o3roa7br 20 59 gray gray JJ cord-005146-o3roa7br 20 60 matter matter NN cord-005146-o3roa7br 20 61 . . . cord-005146-o3roa7br 21 1 Several several JJ cord-005146-o3roa7br 21 2 experimental experimental JJ cord-005146-o3roa7br 21 3 studies study NNS cord-005146-o3roa7br 21 4 of of IN cord-005146-o3roa7br 21 5 hyperthermia hyperthermia NN cord-005146-o3roa7br 21 6 ( ( -LRB- cord-005146-o3roa7br 21 7 Barnard Barnard NNP cord-005146-o3roa7br 21 8 et et NNP cord-005146-o3roa7br 21 9 al al NNP cord-005146-o3roa7br 21 10 . . NNP cord-005146-o3roa7br 21 11 , , , cord-005146-o3roa7br 21 12 1956 1956 CD cord-005146-o3roa7br 21 13 ; ; . cord-005146-o3roa7br 22 1 Britt Britt NNP cord-005146-o3roa7br 22 2 et et NNP cord-005146-o3roa7br 22 3 al al NNP cord-005146-o3roa7br 22 4 . . . cord-005146-o3roa7br 23 1 , , , cord-005146-o3roa7br 23 2 1983 1983 CD cord-005146-o3roa7br 23 3 ; ; : cord-005146-o3roa7br 23 4 Lyons Lyons NNP cord-005146-o3roa7br 23 5 et et NNP cord-005146-o3roa7br 23 6 aI. ai. NN cord-005146-o3roa7br 23 7 , , , cord-005146-o3roa7br 23 8 1984 1984 CD cord-005146-o3roa7br 23 9 ) ) -RRB- cord-005146-o3roa7br 23 10 have have VBP cord-005146-o3roa7br 23 11 also also RB cord-005146-o3roa7br 23 12 demonstrated demonstrate VBN cord-005146-o3roa7br 23 13 that that IN cord-005146-o3roa7br 23 14 acute acute JJ cord-005146-o3roa7br 23 15 changes change NNS cord-005146-o3roa7br 23 16 , , , cord-005146-o3roa7br 23 17 including include VBG cord-005146-o3roa7br 23 18 myelin myelin NN cord-005146-o3roa7br 23 19 sheath sheath NN cord-005146-o3roa7br 23 20 breakdown breakdown NN cord-005146-o3roa7br 23 21 , , , cord-005146-o3roa7br 23 22 vasogenic vasogenic NNP cord-005146-o3roa7br 23 23 oedema oedema NN cord-005146-o3roa7br 23 24 and and CC cord-005146-o3roa7br 23 25 * * NFP cord-005146-o3roa7br 23 26 To to TO cord-005146-o3roa7br 23 27 whom whom WP cord-005146-o3roa7br 23 28 correspondence correspondence NN cord-005146-o3roa7br 23 29 should should MD cord-005146-o3roa7br 23 30 be be VB cord-005146-o3roa7br 23 31 addressed address VBN cord-005146-o3roa7br 23 32 . . . cord-005146-o3roa7br 24 1 haemorrhage haemorrhage NN cord-005146-o3roa7br 24 2 , , , cord-005146-o3roa7br 24 3 were be VBD cord-005146-o3roa7br 24 4 found find VBN cord-005146-o3roa7br 24 5 mainly mainly RB cord-005146-o3roa7br 24 6 in in IN cord-005146-o3roa7br 24 7 the the DT cord-005146-o3roa7br 24 8 white white JJ cord-005146-o3roa7br 24 9 matter matter NN cord-005146-o3roa7br 24 10 after after IN cord-005146-o3roa7br 24 11 heat heat NN cord-005146-o3roa7br 24 12 treatment treatment NN cord-005146-o3roa7br 24 13 at at IN cord-005146-o3roa7br 24 14 a a DT cord-005146-o3roa7br 24 15 temperature temperature NN cord-005146-o3roa7br 24 16 of of IN cord-005146-o3roa7br 24 17 over over IN cord-005146-o3roa7br 24 18 42 42 CD cord-005146-o3roa7br 24 19 ~ ~ CD cord-005146-o3roa7br 24 20 C c NN cord-005146-o3roa7br 24 21 for for IN cord-005146-o3roa7br 24 22 about about RB cord-005146-o3roa7br 24 23 60 60 CD cord-005146-o3roa7br 24 24 min min NN cord-005146-o3roa7br 24 25 . . . cord-005146-o3roa7br 25 1 These these DT cord-005146-o3roa7br 25 2 studies study NNS cord-005146-o3roa7br 25 3 were be VBD cord-005146-o3roa7br 25 4 done do VBN cord-005146-o3roa7br 25 5 by by IN cord-005146-o3roa7br 25 6 light light JJ cord-005146-o3roa7br 25 7 microscopy microscopy NN cord-005146-o3roa7br 25 8 only only RB cord-005146-o3roa7br 25 9 , , , cord-005146-o3roa7br 25 10 and and CC cord-005146-o3roa7br 25 11 no no DT cord-005146-o3roa7br 25 12 ultrastructural ultrastructural JJ cord-005146-o3roa7br 25 13 study study NN cord-005146-o3roa7br 25 14 has have VBZ cord-005146-o3roa7br 25 15 so so RB cord-005146-o3roa7br 25 16 far far RB cord-005146-o3roa7br 25 17 been be VBN cord-005146-o3roa7br 25 18 reported report VBN cord-005146-o3roa7br 25 19 with with IN cord-005146-o3roa7br 25 20 regard regard NN cord-005146-o3roa7br 25 21 to to IN cord-005146-o3roa7br 25 22 the the DT cord-005146-o3roa7br 25 23 effects effect NNS cord-005146-o3roa7br 25 24 of of IN cord-005146-o3roa7br 25 25 hyperthermia hyperthermia NN cord-005146-o3roa7br 25 26 on on IN cord-005146-o3roa7br 25 27 normal normal JJ cord-005146-o3roa7br 25 28 CNS CNS NNP cord-005146-o3roa7br 25 29 tissues tissue NNS cord-005146-o3roa7br 25 30 . . . cord-005146-o3roa7br 26 1 To to TO cord-005146-o3roa7br 26 2 investigate investigate VB cord-005146-o3roa7br 26 3 more more RBR cord-005146-o3roa7br 26 4 precisely precisely RB cord-005146-o3roa7br 26 5 the the DT cord-005146-o3roa7br 26 6 histological histological JJ cord-005146-o3roa7br 26 7 changes change NNS cord-005146-o3roa7br 26 8 induced induce VBN cord-005146-o3roa7br 26 9 in in IN cord-005146-o3roa7br 26 10 CNS CNS NNP cord-005146-o3roa7br 26 11 tissues tissue NNS cord-005146-o3roa7br 26 12 after after IN cord-005146-o3roa7br 26 13 high high JJ cord-005146-o3roa7br 26 14 temperature temperature NN cord-005146-o3roa7br 26 15 treatment treatment NN cord-005146-o3roa7br 26 16 , , , cord-005146-o3roa7br 26 17 heat heat NN cord-005146-o3roa7br 26 18 injury injury NN cord-005146-o3roa7br 26 19 was be VBD cord-005146-o3roa7br 26 20 induced induce VBN cord-005146-o3roa7br 26 21 in in IN cord-005146-o3roa7br 26 22 the the DT cord-005146-o3roa7br 26 23 rat rat NN cord-005146-o3roa7br 26 24 spinal spinal JJ cord-005146-o3roa7br 26 25 cord cord NN cord-005146-o3roa7br 26 26 by by IN cord-005146-o3roa7br 26 27 transdural transdural NNP cord-005146-o3roa7br 26 28 heat heat NNP cord-005146-o3roa7br 26 29 application application NN cord-005146-o3roa7br 26 30 , , , cord-005146-o3roa7br 26 31 and and CC cord-005146-o3roa7br 26 32 early early JJ cord-005146-o3roa7br 26 33 degradation degradation NN cord-005146-o3roa7br 26 34 and and CC cord-005146-o3roa7br 26 35 subsequent subsequent JJ cord-005146-o3roa7br 26 36 repair repair NN cord-005146-o3roa7br 26 37 of of IN cord-005146-o3roa7br 26 38 the the DT cord-005146-o3roa7br 26 39 affected affect VBN cord-005146-o3roa7br 26 40 tissues tissue NNS cord-005146-o3roa7br 26 41 were be VBD cord-005146-o3roa7br 26 42 examined examine VBN cord-005146-o3roa7br 26 43 by by IN cord-005146-o3roa7br 26 44 light light NN cord-005146-o3roa7br 26 45 and and CC cord-005146-o3roa7br 26 46 electron electron NN cord-005146-o3roa7br 26 47 microscopy microscopy NN cord-005146-o3roa7br 26 48 . . . cord-005146-o3roa7br 27 1 Thirty thirty CD cord-005146-o3roa7br 27 2 male male JJ cord-005146-o3roa7br 27 3 rats rat NNS cord-005146-o3roa7br 27 4 ( ( -LRB- cord-005146-o3roa7br 27 5 Wistar Wistar NNP cord-005146-o3roa7br 27 6 strain strain NN cord-005146-o3roa7br 27 7 ) ) -RRB- cord-005146-o3roa7br 27 8 , , , cord-005146-o3roa7br 27 9 weighing weigh VBG cord-005146-o3roa7br 27 10 200 200 CD cord-005146-o3roa7br 27 11 - - SYM cord-005146-o3roa7br 27 12 300 300 CD cord-005146-o3roa7br 27 13 g g NN cord-005146-o3roa7br 27 14 , , , cord-005146-o3roa7br 27 15 were be VBD cord-005146-o3roa7br 27 16 used use VBN cord-005146-o3roa7br 27 17 . . . cord-005146-o3roa7br 28 1 The the DT cord-005146-o3roa7br 28 2 animals animal NNS cord-005146-o3roa7br 28 3 were be VBD cord-005146-o3roa7br 28 4 anesthetized anesthetize VBN cord-005146-o3roa7br 28 5 by by IN cord-005146-o3roa7br 28 6 intraperitoneal intraperitoneal JJ cord-005146-o3roa7br 28 7 injection injection NN cord-005146-o3roa7br 28 8 of of IN cord-005146-o3roa7br 28 9 Nembutal Nembutal NNP cord-005146-o3roa7br 28 10 ( ( -LRB- cord-005146-o3roa7br 28 11 sodium sodium NN cord-005146-o3roa7br 28 12 pentobarbital pentobarbital NN cord-005146-o3roa7br 28 13 , , , cord-005146-o3roa7br 28 14 100 100 CD cord-005146-o3roa7br 28 15 mg mg NNP cord-005146-o3roa7br 28 16 / / SYM cord-005146-o3roa7br 28 17 kg kg NN cord-005146-o3roa7br 28 18 body body NN cord-005146-o3roa7br 28 19 weight weight NN cord-005146-o3roa7br 28 20 ) ) -RRB- cord-005146-o3roa7br 28 21 , , , cord-005146-o3roa7br 28 22 and and CC cord-005146-o3roa7br 28 23 the the DT cord-005146-o3roa7br 28 24 thoracolumbar thoracolumbar NN cord-005146-o3roa7br 28 25 region region NN cord-005146-o3roa7br 28 26 of of IN cord-005146-o3roa7br 28 27 the the DT cord-005146-o3roa7br 28 28 spinal spinal JJ cord-005146-o3roa7br 28 29 cord cord NN cord-005146-o3roa7br 28 30 was be VBD cord-005146-o3roa7br 28 31 exposed expose VBN cord-005146-o3roa7br 28 32 through through IN cord-005146-o3roa7br 28 33 a a DT cord-005146-o3roa7br 28 34 rectangular rectangular JJ cord-005146-o3roa7br 28 35 window window NN cord-005146-o3roa7br 28 36 made make VBN cord-005146-o3roa7br 28 37 by by IN cord-005146-o3roa7br 28 38 partial partial JJ cord-005146-o3roa7br 28 39 laminectomy laminectomy NN cord-005146-o3roa7br 28 40 . . . cord-005146-o3roa7br 29 1 A a DT cord-005146-o3roa7br 29 2 polyethylene polyethylene NN cord-005146-o3roa7br 29 3 tube tube NN cord-005146-o3roa7br 29 4 , , , cord-005146-o3roa7br 29 5 2 2 CD cord-005146-o3roa7br 29 6 mm mm NNS cord-005146-o3roa7br 29 7 in in IN cord-005146-o3roa7br 29 8 diameter diameter NN cord-005146-o3roa7br 29 9 , , , cord-005146-o3roa7br 29 10 was be VBD cord-005146-o3roa7br 29 11 bent bent JJ cord-005146-o3roa7br 29 12 and and CC cord-005146-o3roa7br 29 13 the the DT cord-005146-o3roa7br 29 14 tip tip NN cord-005146-o3roa7br 29 15 of of IN cord-005146-o3roa7br 29 16 the the DT cord-005146-o3roa7br 29 17 bent bent JJ cord-005146-o3roa7br 29 18 end end NN cord-005146-o3roa7br 29 19 was be VBD cord-005146-o3roa7br 29 20 placed place VBN cord-005146-o3roa7br 29 21 on on IN cord-005146-o3roa7br 29 22 the the DT cord-005146-o3roa7br 29 23 0300M864/89 0300m864/89 CD cord-005146-o3roa7br 29 24 $ $ $ cord-005146-o3roa7br 29 25 03.00 03.00 CD cord-005146-o3roa7br 29 26 + + CC cord-005146-o3roa7br 29 27 . . . cord-005146-o3roa7br 30 1 12 12 CD cord-005146-o3roa7br 30 2 9 9 CD cord-005146-o3roa7br 30 3 Chapman Chapman NNP cord-005146-o3roa7br 30 4 and and CC cord-005146-o3roa7br 30 5 Hall Hall NNP cord-005146-o3roa7br 30 6 Ltd. Ltd. NNP cord-005146-o3roa7br 30 7 Water Water NNP cord-005146-o3roa7br 30 8 was be VBD cord-005146-o3roa7br 30 9 circulated circulate VBN cord-005146-o3roa7br 30 10 by by IN cord-005146-o3roa7br 30 11 a a DT cord-005146-o3roa7br 30 12 flow flow NN cord-005146-o3roa7br 30 13 roller roller NN cord-005146-o3roa7br 30 14 pump pump NN cord-005146-o3roa7br 30 15 through through IN cord-005146-o3roa7br 30 16 a a DT cord-005146-o3roa7br 30 17 2 2 CD cord-005146-o3roa7br 30 18 ram ram NN cord-005146-o3roa7br 30 19 - - HYPH cord-005146-o3roa7br 30 20 diameter diameter NN cord-005146-o3roa7br 30 21 polyethylene polyethylene NN cord-005146-o3roa7br 30 22 tube tube NN cord-005146-o3roa7br 30 23 . . . cord-005146-o3roa7br 31 1 The the DT cord-005146-o3roa7br 31 2 water water NN cord-005146-o3roa7br 31 3 was be VBD cord-005146-o3roa7br 31 4 warmed warm VBN cord-005146-o3roa7br 31 5 to to IN cord-005146-o3roa7br 31 6 approximately approximately RB cord-005146-o3roa7br 31 7 60 60 CD cord-005146-o3roa7br 31 8 ~ ~ CD cord-005146-o3roa7br 31 9 C c NN cord-005146-o3roa7br 31 10 in in IN cord-005146-o3roa7br 31 11 the the DT cord-005146-o3roa7br 31 12 water water NN cord-005146-o3roa7br 31 13 bath bath NN cord-005146-o3roa7br 31 14 so so IN cord-005146-o3roa7br 31 15 that that IN cord-005146-o3roa7br 31 16 the the DT cord-005146-o3roa7br 31 17 temperature temperature NN cord-005146-o3roa7br 31 18 of of IN cord-005146-o3roa7br 31 19 the the DT cord-005146-o3roa7br 31 20 thermocouple thermocouple NN cord-005146-o3roa7br 31 21 at at IN cord-005146-o3roa7br 31 22 the the DT cord-005146-o3roa7br 31 23 bent bent JJ cord-005146-o3roa7br 31 24 tube tube NN cord-005146-o3roa7br 31 25 could could MD cord-005146-o3roa7br 31 26 be be VB cord-005146-o3roa7br 31 27 kept keep VBN cord-005146-o3roa7br 31 28 at at IN cord-005146-o3roa7br 31 29 48 48 CD cord-005146-o3roa7br 31 30 - - SYM cord-005146-o3roa7br 31 31 50 50 CD cord-005146-o3roa7br 32 1 ~ ~ NFP cord-005146-o3roa7br 32 2 C. C. NNP cord-005146-o3roa7br 32 3 The the DT cord-005146-o3roa7br 32 4 tube tube NN cord-005146-o3roa7br 32 5 was be VBD cord-005146-o3roa7br 32 6 wrapped wrap VBN cord-005146-o3roa7br 32 7 with with IN cord-005146-o3roa7br 32 8 adiabatic adiabatic JJ cord-005146-o3roa7br 32 9 material material NN cord-005146-o3roa7br 32 10 , , , cord-005146-o3roa7br 32 11 and and CC cord-005146-o3roa7br 32 12 the the DT cord-005146-o3roa7br 32 13 tip tip NN cord-005146-o3roa7br 32 14 of of IN cord-005146-o3roa7br 32 15 the the DT cord-005146-o3roa7br 32 16 bent bent JJ cord-005146-o3roa7br 32 17 tube tube NN cord-005146-o3roa7br 32 18 was be VBD cord-005146-o3roa7br 32 19 in in IN cord-005146-o3roa7br 32 20 contact contact NN cord-005146-o3roa7br 32 21 with with IN cord-005146-o3roa7br 32 22 the the DT cord-005146-o3roa7br 32 23 dural dural JJ cord-005146-o3roa7br 32 24 surface surface NN cord-005146-o3roa7br 32 25 of of IN cord-005146-o3roa7br 32 26 the the DT cord-005146-o3roa7br 32 27 spinal spinal JJ cord-005146-o3roa7br 32 28 cord cord NN cord-005146-o3roa7br 32 29 . . . cord-005146-o3roa7br 33 1 dura dura NNP cord-005146-o3roa7br 33 2 mater mater NN cord-005146-o3roa7br 33 3 using use VBG cord-005146-o3roa7br 33 4 a a DT cord-005146-o3roa7br 33 5 stereotaxic stereotaxic JJ cord-005146-o3roa7br 33 6 device device NN cord-005146-o3roa7br 33 7 . . . cord-005146-o3roa7br 34 1 Hot hot JJ cord-005146-o3roa7br 34 2 water water NN cord-005146-o3roa7br 34 3 , , , cord-005146-o3roa7br 34 4 heated heat VBN cord-005146-o3roa7br 34 5 in in IN cord-005146-o3roa7br 34 6 a a DT cord-005146-o3roa7br 34 7 water water NN cord-005146-o3roa7br 34 8 bath bath NN cord-005146-o3roa7br 34 9 ( ( -LRB- cord-005146-o3roa7br 34 10 Yamato Yamato NNP cord-005146-o3roa7br 34 11 BK33 BK33 NNP cord-005146-o3roa7br 34 12 ) ) -RRB- cord-005146-o3roa7br 34 13 , , , cord-005146-o3roa7br 34 14 was be VBD cord-005146-o3roa7br 34 15 circulated circulate VBN cord-005146-o3roa7br 34 16 through through IN cord-005146-o3roa7br 34 17 this this DT cord-005146-o3roa7br 34 18 tube tube NN cord-005146-o3roa7br 34 19 . . . cord-005146-o3roa7br 35 1 tube tube NN cord-005146-o3roa7br 35 2 . . . cord-005146-o3roa7br 36 1 The the DT cord-005146-o3roa7br 36 2 temperature temperature NN cord-005146-o3roa7br 36 3 was be VBD cord-005146-o3roa7br 36 4 maintained maintain VBN cord-005146-o3roa7br 36 5 at at IN cord-005146-o3roa7br 36 6 48 48 CD cord-005146-o3roa7br 36 7 - - SYM cord-005146-o3roa7br 36 8 50 50 CD cord-005146-o3roa7br 36 9 ~ ~ NFP cord-005146-o3roa7br 36 10 C c NN cord-005146-o3roa7br 36 11 for for IN cord-005146-o3roa7br 36 12 1 1 CD cord-005146-o3roa7br 36 13 h h NN cord-005146-o3roa7br 36 14 , , , cord-005146-o3roa7br 36 15 as as IN cord-005146-o3roa7br 36 16 monitored monitor VBN cord-005146-o3roa7br 36 17 with with IN cord-005146-o3roa7br 36 18 a a DT cord-005146-o3roa7br 36 19 thermocouple thermocouple NN cord-005146-o3roa7br 36 20 ( ( -LRB- cord-005146-o3roa7br 36 21 1.0 1.0 CD cord-005146-o3roa7br 36 22 mm mm NNS cord-005146-o3roa7br 36 23 in in IN cord-005146-o3roa7br 36 24 diameter diameter NN cord-005146-o3roa7br 36 25 ) ) -RRB- cord-005146-o3roa7br 36 26 inserted insert VBN cord-005146-o3roa7br 36 27 between between IN cord-005146-o3roa7br 36 28 the the DT cord-005146-o3roa7br 36 29 proximal proximal JJ cord-005146-o3roa7br 36 30 and and CC cord-005146-o3roa7br 36 31 distal distal JJ cord-005146-o3roa7br 36 32 limbs limb NNS cord-005146-o3roa7br 36 33 of of IN cord-005146-o3roa7br 36 34 the the DT cord-005146-o3roa7br 36 35 bent bent JJ cord-005146-o3roa7br 36 36 tube tube NN cord-005146-o3roa7br 36 37 , , , cord-005146-o3roa7br 36 38 10 10 CD cord-005146-o3roa7br 36 39 mm mm NNS cord-005146-o3roa7br 36 40 away away RB cord-005146-o3roa7br 36 41 from from IN cord-005146-o3roa7br 36 42 its -PRON- PRP$ cord-005146-o3roa7br 36 43 tip tip NN cord-005146-o3roa7br 37 1 ( ( -LRB- cord-005146-o3roa7br 37 2 Fig Fig NNP cord-005146-o3roa7br 37 3 . . NNP cord-005146-o3roa7br 37 4 1 1 CD cord-005146-o3roa7br 37 5 ) ) -RRB- cord-005146-o3roa7br 37 6 . . . cord-005146-o3roa7br 38 1 Room room NN cord-005146-o3roa7br 38 2 temperature temperature NN cord-005146-o3roa7br 38 3 was be VBD cord-005146-o3roa7br 38 4 kept keep VBN cord-005146-o3roa7br 38 5 at at IN cord-005146-o3roa7br 38 6 28 28 CD cord-005146-o3roa7br 38 7 - - SYM cord-005146-o3roa7br 38 8 30 30 CD cord-005146-o3roa7br 38 9 ~ ~ CD cord-005146-o3roa7br 38 10 C C NNP cord-005146-o3roa7br 38 11 , , , cord-005146-o3roa7br 38 12 and and CC cord-005146-o3roa7br 38 13 the the DT cord-005146-o3roa7br 38 14 tube tube NN cord-005146-o3roa7br 38 15 , , , cord-005146-o3roa7br 38 16 except except IN cord-005146-o3roa7br 38 17 the the DT cord-005146-o3roa7br 38 18 bent bent JJ cord-005146-o3roa7br 38 19 tip tip NN cord-005146-o3roa7br 38 20 , , , cord-005146-o3roa7br 38 21 was be VBD cord-005146-o3roa7br 38 22 shielded shield VBN cord-005146-o3roa7br 38 23 by by IN cord-005146-o3roa7br 38 24 adiabatic adiabatic JJ cord-005146-o3roa7br 38 25 material material NN cord-005146-o3roa7br 38 26 to to TO cord-005146-o3roa7br 38 27 prevent prevent VB cord-005146-o3roa7br 38 28 cooling cooling NN cord-005146-o3roa7br 38 29 by by IN cord-005146-o3roa7br 38 30 air air NN cord-005146-o3roa7br 38 31 . . . cord-005146-o3roa7br 39 1 The the DT cord-005146-o3roa7br 39 2 pressure pressure NN cord-005146-o3roa7br 39 3 on on IN cord-005146-o3roa7br 39 4 the the DT cord-005146-o3roa7br 39 5 dura dura NN cord-005146-o3roa7br 39 6 exerted exert VBN cord-005146-o3roa7br 39 7 by by IN cord-005146-o3roa7br 39 8 the the DT cord-005146-o3roa7br 39 9 tube tube NN cord-005146-o3roa7br 39 10 was be VBD cord-005146-o3roa7br 39 11 not not RB cord-005146-o3roa7br 39 12 so so RB cord-005146-o3roa7br 39 13 great great JJ cord-005146-o3roa7br 39 14 as as IN cord-005146-o3roa7br 39 15 to to TO cord-005146-o3roa7br 39 16 interrupt interrupt VB cord-005146-o3roa7br 39 17 the the DT cord-005146-o3roa7br 39 18 blood blood NN cord-005146-o3roa7br 39 19 flow flow NN cord-005146-o3roa7br 39 20 in in IN cord-005146-o3roa7br 39 21 the the DT cord-005146-o3roa7br 39 22 dorsal dorsal JJ cord-005146-o3roa7br 39 23 vein vein NN cord-005146-o3roa7br 39 24 of of IN cord-005146-o3roa7br 39 25 the the DT cord-005146-o3roa7br 39 26 spinal spinal JJ cord-005146-o3roa7br 39 27 cord cord NN cord-005146-o3roa7br 39 28 , , , cord-005146-o3roa7br 39 29 as as IN cord-005146-o3roa7br 39 30 checked check VBN cord-005146-o3roa7br 39 31 under under IN cord-005146-o3roa7br 39 32 a a DT cord-005146-o3roa7br 39 33 dissecting dissect VBG cord-005146-o3roa7br 39 34 microscope microscope NN cord-005146-o3roa7br 39 35 . . . cord-005146-o3roa7br 40 1 Control control NN cord-005146-o3roa7br 40 2 animals animal NNS cord-005146-o3roa7br 40 3 were be VBD cord-005146-o3roa7br 40 4 operated operate VBN cord-005146-o3roa7br 40 5 on on IN cord-005146-o3roa7br 40 6 and and CC cord-005146-o3roa7br 40 7 treated treat VBN cord-005146-o3roa7br 40 8 in in IN cord-005146-o3roa7br 40 9 the the DT cord-005146-o3roa7br 40 10 same same JJ cord-005146-o3roa7br 40 11 manner manner NN cord-005146-o3roa7br 40 12 , , , cord-005146-o3roa7br 40 13 except except IN cord-005146-o3roa7br 40 14 that that DT cord-005146-o3roa7br 40 15 hot hot JJ cord-005146-o3roa7br 40 16 water water NN cord-005146-o3roa7br 40 17 was be VBD cord-005146-o3roa7br 40 18 not not RB cord-005146-o3roa7br 40 19 circulated circulate VBN cord-005146-o3roa7br 40 20 through through IN cord-005146-o3roa7br 40 21 the the DT cord-005146-o3roa7br 40 22 tuba tuba NN cord-005146-o3roa7br 40 23 in in IN cord-005146-o3roa7br 40 24 two two CD cord-005146-o3roa7br 40 25 animals animal NNS cord-005146-o3roa7br 40 26 , , , cord-005146-o3roa7br 40 27 and and CC cord-005146-o3roa7br 40 28 hot hot JJ cord-005146-o3roa7br 40 29 water water NN cord-005146-o3roa7br 40 30 at at IN cord-005146-o3roa7br 40 31 40M5 40m5 CD cord-005146-o3roa7br 41 1 ~ ~ NFP cord-005146-o3roa7br 41 2 C C NNP cord-005146-o3roa7br 41 3 was be VBD cord-005146-o3roa7br 41 4 circulated circulate VBN cord-005146-o3roa7br 41 5 in in IN cord-005146-o3roa7br 41 6 five five CD cord-005146-o3roa7br 41 7 animals animal NNS cord-005146-o3roa7br 41 8 . . . cord-005146-o3roa7br 42 1 The the DT cord-005146-o3roa7br 42 2 animals animal NNS cord-005146-o3roa7br 42 3 were be VBD cord-005146-o3roa7br 42 4 killed kill VBN cord-005146-o3roa7br 42 5 1 1 CD cord-005146-o3roa7br 42 6 ( ( -LRB- cord-005146-o3roa7br 42 7 n-4 n-4 NNP cord-005146-o3roa7br 42 8 ) ) -RRB- cord-005146-o3roa7br 42 9 , , , cord-005146-o3roa7br 42 10 3 3 CD cord-005146-o3roa7br 42 11 ( ( -LRB- cord-005146-o3roa7br 42 12 n=4 n=4 NNP cord-005146-o3roa7br 42 13 ) ) -RRB- cord-005146-o3roa7br 42 14 , , , cord-005146-o3roa7br 42 15 5 5 CD cord-005146-o3roa7br 42 16 ( ( -LRB- cord-005146-o3roa7br 42 17 n~3 n~3 NNP cord-005146-o3roa7br 42 18 ) ) -RRB- cord-005146-o3roa7br 42 19 and and CC cord-005146-o3roa7br 42 20 7 7 CD cord-005146-o3roa7br 42 21 ( ( -LRB- cord-005146-o3roa7br 42 22 n-4 n-4 NNP cord-005146-o3roa7br 42 23 ) ) -RRB- cord-005146-o3roa7br 42 24 days day NNS cord-005146-o3roa7br 42 25 , , , cord-005146-o3roa7br 42 26 and and CC cord-005146-o3roa7br 42 27 2 2 LS cord-005146-o3roa7br 42 28 ( ( -LRB- cord-005146-o3roa7br 42 29 n=4 n=4 NNS cord-005146-o3roa7br 42 30 ) ) -RRB- cord-005146-o3roa7br 42 31 and and CC cord-005146-o3roa7br 42 32 4 4 CD cord-005146-o3roa7br 42 33 weeks week NNS cord-005146-o3roa7br 42 34 ( ( -LRB- cord-005146-o3roa7br 42 35 n=4 n=4 NNS cord-005146-o3roa7br 42 36 ) ) -RRB- cord-005146-o3roa7br 42 37 after after IN cord-005146-o3roa7br 42 38 the the DT cord-005146-o3roa7br 42 39 operation operation NN cord-005146-o3roa7br 42 40 by by IN cord-005146-o3roa7br 42 41 perfusion perfusion NN cord-005146-o3roa7br 42 42 through through IN cord-005146-o3roa7br 42 43 the the DT cord-005146-o3roa7br 42 44 heart heart NN cord-005146-o3roa7br 42 45 with with IN cord-005146-o3roa7br 42 46 a a DT cord-005146-o3roa7br 42 47 fixative fixative NN cord-005146-o3roa7br 42 48 containing contain VBG cord-005146-o3roa7br 42 49 2.0 2.0 CD cord-005146-o3roa7br 42 50 % % NN cord-005146-o3roa7br 42 51 paraformaldehyde paraformaldehyde NN cord-005146-o3roa7br 42 52 and and CC cord-005146-o3roa7br 42 53 2.5 2.5 CD cord-005146-o3roa7br 42 54 % % NN cord-005146-o3roa7br 42 55 glutaraldehyde glutaraldehyde VBN cord-005146-o3roa7br 42 56 in in IN cord-005146-o3roa7br 42 57 0.1 0.1 CD cord-005146-o3roa7br 42 58 M m NN cord-005146-o3roa7br 42 59 cacodylate cacodylate NN cord-005146-o3roa7br 42 60 buffer buffer NN cord-005146-o3roa7br 42 61 . . . cord-005146-o3roa7br 43 1 The the DT cord-005146-o3roa7br 43 2 treated treated JJ cord-005146-o3roa7br 43 3 parts part NNS cord-005146-o3roa7br 43 4 of of IN cord-005146-o3roa7br 43 5 the the DT cord-005146-o3roa7br 43 6 cord cord NN cord-005146-o3roa7br 43 7 were be VBD cord-005146-o3roa7br 43 8 excised excise VBN cord-005146-o3roa7br 43 9 , , , cord-005146-o3roa7br 43 10 together together RB cord-005146-o3roa7br 43 11 with with IN cord-005146-o3roa7br 43 12 the the DT cord-005146-o3roa7br 43 13 adjacent adjacent JJ cord-005146-o3roa7br 43 14 cranial cranial JJ cord-005146-o3roa7br 43 15 and and CC cord-005146-o3roa7br 43 16 caudal caudal JJ cord-005146-o3roa7br 43 17 segments segment NNS cord-005146-o3roa7br 43 18 and and CC cord-005146-o3roa7br 43 19 stored store VBN cord-005146-o3roa7br 43 20 overnight overnight RB cord-005146-o3roa7br 43 21 in in IN cord-005146-o3roa7br 43 22 the the DT cord-005146-o3roa7br 43 23 same same JJ cord-005146-o3roa7br 43 24 fixative fixative NN cord-005146-o3roa7br 43 25 . . . cord-005146-o3roa7br 44 1 Specimens specimen NNS cord-005146-o3roa7br 44 2 were be VBD cord-005146-o3roa7br 44 3 cut cut VBN cord-005146-o3roa7br 44 4 into into IN cord-005146-o3roa7br 44 5 small small JJ cord-005146-o3roa7br 44 6 blocks block NNS cord-005146-o3roa7br 44 7 , , , cord-005146-o3roa7br 44 8 and and CC cord-005146-o3roa7br 44 9 were be VBD cord-005146-o3roa7br 44 10 postfixed postfixed JJ cord-005146-o3roa7br 44 11 in in IN cord-005146-o3roa7br 44 12 1.0 1.0 CD cord-005146-o3roa7br 44 13 % % NN cord-005146-o3roa7br 44 14 osmium osmium NN cord-005146-o3roa7br 44 15 tetroxide tetroxide NN cord-005146-o3roa7br 44 16 solution solution NN cord-005146-o3roa7br 44 17 in in IN cord-005146-o3roa7br 44 18 0.1 0.1 CD cord-005146-o3roa7br 44 19 M m NN cord-005146-o3roa7br 44 20 cacodylate cacodylate NN cord-005146-o3roa7br 44 21 buffer buffer NN cord-005146-o3roa7br 44 22 for for IN cord-005146-o3roa7br 44 23 2 2 CD cord-005146-o3roa7br 44 24 h h NN cord-005146-o3roa7br 44 25 , , , cord-005146-o3roa7br 44 26 dehydrated dehydrate VBN cord-005146-o3roa7br 44 27 through through IN cord-005146-o3roa7br 44 28 a a DT cord-005146-o3roa7br 44 29 graded grade VBN cord-005146-o3roa7br 44 30 series series NN cord-005146-o3roa7br 44 31 of of IN cord-005146-o3roa7br 44 32 ethanol ethanol NN cord-005146-o3roa7br 44 33 , , , cord-005146-o3roa7br 44 34 and and CC cord-005146-o3roa7br 44 35 embedded embed VBN cord-005146-o3roa7br 44 36 in in IN cord-005146-o3roa7br 44 37 Epon Epon NNP cord-005146-o3roa7br 44 38 812 812 CD cord-005146-o3roa7br 44 39 . . . cord-005146-o3roa7br 45 1 Ultrathin ultrathin JJ cord-005146-o3roa7br 45 2 sections section NNS cord-005146-o3roa7br 45 3 were be VBD cord-005146-o3roa7br 45 4 cut cut VBN cord-005146-o3roa7br 45 5 on on IN cord-005146-o3roa7br 45 6 a a DT cord-005146-o3roa7br 45 7 LKB LKB NNP cord-005146-o3roa7br 45 8 Ultrotome Ultrotome NNP cord-005146-o3roa7br 45 9 and and CC cord-005146-o3roa7br 45 10 observed observe VBD cord-005146-o3roa7br 45 11 in in IN cord-005146-o3roa7br 45 12 a a DT cord-005146-o3roa7br 45 13 JEOL-100B jeol-100b JJ cord-005146-o3roa7br 45 14 electron electron NN cord-005146-o3roa7br 45 15 microscope microscope NN cord-005146-o3roa7br 45 16 after after IN cord-005146-o3roa7br 45 17 double double JJ cord-005146-o3roa7br 45 18 staining staining NN cord-005146-o3roa7br 45 19 with with IN cord-005146-o3roa7br 45 20 uranyl uranyl NN cord-005146-o3roa7br 45 21 acetate acetate NN cord-005146-o3roa7br 45 22 and and CC cord-005146-o3roa7br 45 23 lead lead NN cord-005146-o3roa7br 45 24 citrate citrate NN cord-005146-o3roa7br 45 25 . . . cord-005146-o3roa7br 46 1 Semithin Semithin NNP cord-005146-o3roa7br 46 2 sections section NNS cord-005146-o3roa7br 46 3 I -PRON- PRP cord-005146-o3roa7br 46 4 p p NN cord-005146-o3roa7br 47 1 ~m ~m NNP cord-005146-o3roa7br 47 2 thick thick JJ cord-005146-o3roa7br 47 3 were be VBD cord-005146-o3roa7br 47 4 stained stain VBN cord-005146-o3roa7br 47 5 with with IN cord-005146-o3roa7br 47 6 1 1 CD cord-005146-o3roa7br 47 7 % % NN cord-005146-o3roa7br 47 8 toluidine toluidine NN cord-005146-o3roa7br 47 9 blue blue NNP cord-005146-o3roa7br 47 10 and and CC cord-005146-o3roa7br 47 11 observed observe VBN cord-005146-o3roa7br 47 12 by by IN cord-005146-o3roa7br 47 13 light light JJ cord-005146-o3roa7br 47 14 microscopy microscopy NNS cord-005146-o3roa7br 47 15 . . . cord-005146-o3roa7br 48 1 The the DT cord-005146-o3roa7br 48 2 rats rat NNS cord-005146-o3roa7br 48 3 did do VBD cord-005146-o3roa7br 48 4 not not RB cord-005146-o3roa7br 48 5 show show VB cord-005146-o3roa7br 48 6 any any DT cord-005146-o3roa7br 48 7 gait gait NN cord-005146-o3roa7br 48 8 or or CC cord-005146-o3roa7br 48 9 other other JJ cord-005146-o3roa7br 48 10 behaviour behaviour NN cord-005146-o3roa7br 48 11 disturbance disturbance NN cord-005146-o3roa7br 48 12 after after IN cord-005146-o3roa7br 48 13 the the DT cord-005146-o3roa7br 48 14 operation operation NN cord-005146-o3roa7br 48 15 . . . cord-005146-o3roa7br 49 1 The the DT cord-005146-o3roa7br 49 2 lesion lesion NN cord-005146-o3roa7br 49 3 resulting result VBG cord-005146-o3roa7br 49 4 from from IN cord-005146-o3roa7br 49 5 the the DT cord-005146-o3roa7br 49 6 heat heat NN cord-005146-o3roa7br 49 7 treatment treatment NN cord-005146-o3roa7br 49 8 was be VBD cord-005146-o3roa7br 49 9 confined confine VBN cord-005146-o3roa7br 49 10 within within IN cord-005146-o3roa7br 49 11 the the DT cord-005146-o3roa7br 49 12 dorsal dorsal JJ cord-005146-o3roa7br 49 13 funiculus funiculu NNS cord-005146-o3roa7br 49 14 of of IN cord-005146-o3roa7br 49 15 the the DT cord-005146-o3roa7br 49 16 spinal spinal JJ cord-005146-o3roa7br 49 17 cord cord NN cord-005146-o3roa7br 49 18 . . . cord-005146-o3roa7br 50 1 The the DT cord-005146-o3roa7br 50 2 affected affected JJ cord-005146-o3roa7br 50 3 area area NN cord-005146-o3roa7br 50 4 was be VBD cord-005146-o3roa7br 50 5 approximately approximately RB cord-005146-o3roa7br 50 6 i i PRP cord-005146-o3roa7br 50 7 mm mm VBP cord-005146-o3roa7br 50 8 long long RB cord-005146-o3roa7br 50 9 , , , cord-005146-o3roa7br 50 10 and and CC cord-005146-o3roa7br 50 11 less less JJR cord-005146-o3roa7br 50 12 than than IN cord-005146-o3roa7br 50 13 1ram 1ram CD cord-005146-o3roa7br 50 14 wide wide JJ cord-005146-o3roa7br 50 15 at at IN cord-005146-o3roa7br 50 16 the the DT cord-005146-o3roa7br 50 17 dorsal dorsal JJ cord-005146-o3roa7br 50 18 surface surface NN cord-005146-o3roa7br 50 19 of of IN cord-005146-o3roa7br 50 20 the the DT cord-005146-o3roa7br 50 21 spinal spinal JJ cord-005146-o3roa7br 50 22 cord cord NN cord-005146-o3roa7br 50 23 . . . cord-005146-o3roa7br 51 1 The the DT cord-005146-o3roa7br 51 2 depth depth NN cord-005146-o3roa7br 51 3 of of IN cord-005146-o3roa7br 51 4 the the DT cord-005146-o3roa7br 51 5 lesion lesion NN cord-005146-o3roa7br 51 6 varied vary VBN cord-005146-o3roa7br 51 7 from from IN cord-005146-o3roa7br 51 8 0.4 0.4 CD cord-005146-o3roa7br 51 9 to to TO cord-005146-o3roa7br 51 10 0.7 0.7 CD cord-005146-o3roa7br 51 11 mm mm NNS cord-005146-o3roa7br 51 12 . . . cord-005146-o3roa7br 52 1 At at IN cord-005146-o3roa7br 52 2 every every DT cord-005146-o3roa7br 52 3 post post JJ cord-005146-o3roa7br 52 4 - - JJ cord-005146-o3roa7br 52 5 treatment treatment JJ cord-005146-o3roa7br 52 6 stage stage NN cord-005146-o3roa7br 52 7 only only RB cord-005146-o3roa7br 52 8 a a DT cord-005146-o3roa7br 52 9 few few JJ cord-005146-o3roa7br 52 10 degenerated degenerate VBN cord-005146-o3roa7br 52 11 axons axon NNS cord-005146-o3roa7br 52 12 were be VBD cord-005146-o3roa7br 52 13 observed observe VBN cord-005146-o3roa7br 52 14 in in IN cord-005146-o3roa7br 52 15 the the DT cord-005146-o3roa7br 52 16 dorsal dorsal JJ cord-005146-o3roa7br 52 17 funiculus funiculu NNS cord-005146-o3roa7br 52 18 at at IN cord-005146-o3roa7br 52 19 levels level NNS cord-005146-o3roa7br 52 20 cranial cranial JJ cord-005146-o3roa7br 52 21 to to IN cord-005146-o3roa7br 52 22 the the DT cord-005146-o3roa7br 52 23 lesion lesion NN cord-005146-o3roa7br 52 24 , , , cord-005146-o3roa7br 52 25 indicating indicate VBG cord-005146-o3roa7br 52 26 that that IN cord-005146-o3roa7br 52 27 the the DT cord-005146-o3roa7br 52 28 axons axon NNS cord-005146-o3roa7br 52 29 themselves -PRON- PRP cord-005146-o3roa7br 52 30 were be VBD cord-005146-o3roa7br 52 31 not not RB cord-005146-o3roa7br 52 32 damaged damage VBN cord-005146-o3roa7br 52 33 by by IN cord-005146-o3roa7br 52 34 the the DT cord-005146-o3roa7br 52 35 heat heat NN cord-005146-o3roa7br 52 36 treatment treatment NN cord-005146-o3roa7br 52 37 . . . cord-005146-o3roa7br 53 1 In in IN cord-005146-o3roa7br 53 2 the the DT cord-005146-o3roa7br 53 3 control control NN cord-005146-o3roa7br 53 4 cases case VBZ cord-005146-o3roa7br 53 5 the the DT cord-005146-o3roa7br 53 6 dorsal dorsal JJ cord-005146-o3roa7br 53 7 surface surface NN cord-005146-o3roa7br 53 8 of of IN cord-005146-o3roa7br 53 9 the the DT cord-005146-o3roa7br 53 10 spinal spinal JJ cord-005146-o3roa7br 53 11 cord cord NN cord-005146-o3roa7br 53 12 was be VBD cord-005146-o3roa7br 53 13 deformed deform VBN cord-005146-o3roa7br 53 14 to to IN cord-005146-o3roa7br 53 15 some some DT cord-005146-o3roa7br 53 16 extent extent NN cord-005146-o3roa7br 53 17 , , , cord-005146-o3roa7br 53 18 presumably presumably RB cord-005146-o3roa7br 53 19 due due JJ cord-005146-o3roa7br 53 20 to to IN cord-005146-o3roa7br 53 21 compression compression NN cord-005146-o3roa7br 53 22 by by IN cord-005146-o3roa7br 53 23 the the DT cord-005146-o3roa7br 53 24 tube tube NN cord-005146-o3roa7br 53 25 ' ' '' cord-005146-o3roa7br 53 26 . . . cord-005146-o3roa7br 54 1 However however RB cord-005146-o3roa7br 54 2 , , , cord-005146-o3roa7br 54 3 no no DT cord-005146-o3roa7br 54 4 focus focus NN cord-005146-o3roa7br 54 5 of of IN cord-005146-o3roa7br 54 6 demyelination demyelination NN cord-005146-o3roa7br 54 7 was be VBD cord-005146-o3roa7br 54 8 found find VBN cord-005146-o3roa7br 54 9 in in IN cord-005146-o3roa7br 54 10 the the DT cord-005146-o3roa7br 54 11 dorsal dorsal JJ cord-005146-o3roa7br 54 12 funiculus funiculu NNS cord-005146-o3roa7br 54 13 . . . cord-005146-o3roa7br 55 1 A a DT cord-005146-o3roa7br 55 2 few few JJ cord-005146-o3roa7br 55 3 fibres fibre NNS cord-005146-o3roa7br 55 4 whose whose WP$ cord-005146-o3roa7br 55 5 myelin myelin NN cord-005146-o3roa7br 55 6 sheaths sheath NNS cord-005146-o3roa7br 55 7 were be VBD cord-005146-o3roa7br 55 8 degraded degrade VBN cord-005146-o3roa7br 55 9 in in IN cord-005146-o3roa7br 55 10 the the DT cord-005146-o3roa7br 55 11 treated treated JJ cord-005146-o3roa7br 55 12 part part NN cord-005146-o3roa7br 55 13 of of IN cord-005146-o3roa7br 55 14 the the DT cord-005146-o3roa7br 55 15 dorsal dorsal JJ cord-005146-o3roa7br 55 16 funiculus funiculus NNP cord-005146-o3roa7br 55 17 were be VBD cord-005146-o3roa7br 55 18 noted note VBN cord-005146-o3roa7br 55 19 by by IN cord-005146-o3roa7br 55 20 light light JJ cord-005146-o3roa7br 55 21 microscopy microscopy NNS cord-005146-o3roa7br 55 22 . . . cord-005146-o3roa7br 56 1 Myelinated myelinated JJ cord-005146-o3roa7br 56 2 fibres fibre NNS cord-005146-o3roa7br 56 3 located locate VBN cord-005146-o3roa7br 56 4 near near IN cord-005146-o3roa7br 56 5 the the DT cord-005146-o3roa7br 56 6 pial pial JJ cord-005146-o3roa7br 56 7 surface surface NN cord-005146-o3roa7br 56 8 appeared appear VBD cord-005146-o3roa7br 56 9 loosely loosely RB cord-005146-o3roa7br 56 10 packed pack VBN cord-005146-o3roa7br 56 11 owing owe VBG cord-005146-o3roa7br 56 12 to to IN cord-005146-o3roa7br 56 13 the the DT cord-005146-o3roa7br 56 14 increase increase NN cord-005146-o3roa7br 56 15 of of IN cord-005146-o3roa7br 56 16 extracellular extracellular JJ cord-005146-o3roa7br 56 17 spaces space NNS cord-005146-o3roa7br 56 18 ( ( -LRB- cord-005146-o3roa7br 56 19 Fig Fig NNP cord-005146-o3roa7br 56 20 . . . cord-005146-o3roa7br 56 21 2A 2a CD cord-005146-o3roa7br 56 22 , , , cord-005146-o3roa7br 56 23 B b NN cord-005146-o3roa7br 56 24 ) ) -RRB- cord-005146-o3roa7br 56 25 . . . cord-005146-o3roa7br 57 1 Electron electron NN cord-005146-o3roa7br 57 2 microscopy microscopy NNS cord-005146-o3roa7br 57 3 showed show VBD cord-005146-o3roa7br 57 4 that that IN cord-005146-o3roa7br 57 5 myelin myelin NN cord-005146-o3roa7br 57 6 sheath sheath NN cord-005146-o3roa7br 57 7 lamellae lamella NNS cord-005146-o3roa7br 57 8 of of IN cord-005146-o3roa7br 57 9 some some DT cord-005146-o3roa7br 57 10 myelinated myelinated JJ cord-005146-o3roa7br 57 11 fibres fibre NNS cord-005146-o3roa7br 57 12 were be VBD cord-005146-o3roa7br 57 13 loosened loosen VBN cord-005146-o3roa7br 57 14 or or CC cord-005146-o3roa7br 57 15 even even RB cord-005146-o3roa7br 57 16 broken break VBN cord-005146-o3roa7br 57 17 up up RP cord-005146-o3roa7br 57 18 into into IN cord-005146-o3roa7br 57 19 irregular irregular JJ cord-005146-o3roa7br 57 20 structures structure NNS cord-005146-o3roa7br 57 21 ( ( -LRB- cord-005146-o3roa7br 57 22 Fig Fig NNP cord-005146-o3roa7br 57 23 . . . cord-005146-o3roa7br 57 24 3 3 CD cord-005146-o3roa7br 57 25 ) ) -RRB- cord-005146-o3roa7br 57 26 . . . cord-005146-o3roa7br 58 1 In in IN cord-005146-o3roa7br 58 2 some some DT cord-005146-o3roa7br 58 3 fibres fibre NNS cord-005146-o3roa7br 58 4 the the DT cord-005146-o3roa7br 58 5 internal internal JJ cord-005146-o3roa7br 58 6 loops loop NNS cord-005146-o3roa7br 58 7 of of IN cord-005146-o3roa7br 58 8 myelin myelin NN cord-005146-o3roa7br 58 9 sheaths sheath NNS cord-005146-o3roa7br 58 10 were be VBD cord-005146-o3roa7br 58 11 markedly markedly RB cord-005146-o3roa7br 58 12 swollen swollen JJ cord-005146-o3roa7br 58 13 . . . cord-005146-o3roa7br 59 1 These these DT cord-005146-o3roa7br 59 2 were be VBD cord-005146-o3roa7br 59 3 features feature NNS cord-005146-o3roa7br 59 4 of of IN cord-005146-o3roa7br 59 5 the the DT cord-005146-o3roa7br 59 6 early early JJ cord-005146-o3roa7br 59 7 stages stage NNS cord-005146-o3roa7br 59 8 of of IN cord-005146-o3roa7br 59 9 myelin myelin NN cord-005146-o3roa7br 59 10 sheath sheath NN cord-005146-o3roa7br 59 11 degradation degradation NN cord-005146-o3roa7br 59 12 which which WDT cord-005146-o3roa7br 59 13 finally finally RB cord-005146-o3roa7br 59 14 led lead VBD cord-005146-o3roa7br 59 15 to to IN cord-005146-o3roa7br 59 16 the the DT cord-005146-o3roa7br 59 17 complete complete JJ cord-005146-o3roa7br 59 18 demyelination demyelination NN cord-005146-o3roa7br 59 19 of of IN cord-005146-o3roa7br 59 20 the the DT cord-005146-o3roa7br 59 21 affected affect VBN cord-005146-o3roa7br 59 22 fibres fibre NNS cord-005146-o3roa7br 59 23 . . . cord-005146-o3roa7br 60 1 The the DT cord-005146-o3roa7br 60 2 extracellular extracellular JJ cord-005146-o3roa7br 60 3 spaces space NNS cord-005146-o3roa7br 60 4 between between IN cord-005146-o3roa7br 60 5 the the DT cord-005146-o3roa7br 60 6 axons axon NNS cord-005146-o3roa7br 60 7 were be VBD cord-005146-o3roa7br 60 8 enlarged enlarge VBN cord-005146-o3roa7br 60 9 and and CC cord-005146-o3roa7br 60 10 contained contain VBN cord-005146-o3roa7br 60 11 proteinaceous proteinaceous JJ cord-005146-o3roa7br 60 12 oedema oedema NN cord-005146-o3roa7br 60 13 fluid fluid NN cord-005146-o3roa7br 60 14 and and CC cord-005146-o3roa7br 60 15 electron electron NN cord-005146-o3roa7br 60 16 - - HYPH cord-005146-o3roa7br 60 17 dense dense JJ cord-005146-o3roa7br 60 18 deposits deposit NNS cord-005146-o3roa7br 60 19 of of IN cord-005146-o3roa7br 60 20 fibrin fibrin NN cord-005146-o3roa7br 60 21 . . . cord-005146-o3roa7br 61 1 Astrocyte Astrocyte NNP cord-005146-o3roa7br 61 2 processes process NNS cord-005146-o3roa7br 61 3 , , , cord-005146-o3roa7br 61 4 including include VBG cord-005146-o3roa7br 61 5 endfeet endfeet NNP cord-005146-o3roa7br 61 6 of of IN cord-005146-o3roa7br 61 7 the the DT cord-005146-o3roa7br 61 8 subpial subpial JJ cord-005146-o3roa7br 61 9 glial glial NN cord-005146-o3roa7br 61 10 limiting limit VBG cord-005146-o3roa7br 61 11 membrane membrane NN cord-005146-o3roa7br 61 12 ( ( -LRB- cord-005146-o3roa7br 61 13 GLM GLM NNP cord-005146-o3roa7br 61 14 ) ) -RRB- cord-005146-o3roa7br 61 15 , , , cord-005146-o3roa7br 61 16 were be VBD cord-005146-o3roa7br 61 17 partly partly RB cord-005146-o3roa7br 61 18 swollen swollen JJ cord-005146-o3roa7br 61 19 and and CC cord-005146-o3roa7br 61 20 disrupted disrupt VBN cord-005146-o3roa7br 61 21 , , , cord-005146-o3roa7br 61 22 but but CC cord-005146-o3roa7br 61 23 the the DT cord-005146-o3roa7br 61 24 basal basal NN cord-005146-o3roa7br 61 25 lamina lamina NN cord-005146-o3roa7br 61 26 was be VBD cord-005146-o3roa7br 61 27 preserved preserve VBN cord-005146-o3roa7br 61 28 as as IN cord-005146-o3roa7br 61 29 a a DT cord-005146-o3roa7br 61 30 continuous continuous JJ cord-005146-o3roa7br 61 31 sheet sheet NN cord-005146-o3roa7br 61 32 covering cover VBG cord-005146-o3roa7br 61 33 the the DT cord-005146-o3roa7br 61 34 entire entire JJ cord-005146-o3roa7br 61 35 surface surface NN cord-005146-o3roa7br 61 36 of of IN cord-005146-o3roa7br 61 37 the the DT cord-005146-o3roa7br 61 38 spinal spinal JJ cord-005146-o3roa7br 61 39 cord cord NN cord-005146-o3roa7br 61 40 . . . cord-005146-o3roa7br 62 1 Oligodendrocyte Oligodendrocyte NNP cord-005146-o3roa7br 62 2 processes process NNS cord-005146-o3roa7br 62 3 forming form VBG cord-005146-o3roa7br 62 4 the the DT cord-005146-o3roa7br 62 5 myelin myelin NN cord-005146-o3roa7br 62 6 sheath sheath NN cord-005146-o3roa7br 62 7 outer outer JJ cord-005146-o3roa7br 62 8 loop loop NN cord-005146-o3roa7br 62 9 disappeared disappear VBD cord-005146-o3roa7br 62 10 from from IN cord-005146-o3roa7br 62 11 the the DT cord-005146-o3roa7br 62 12 degenerating degenerate VBG cord-005146-o3roa7br 62 13 myelin myelin NN cord-005146-o3roa7br 62 14 sheaths sheath NNS cord-005146-o3roa7br 62 15 . . . cord-005146-o3roa7br 63 1 In in IN cord-005146-o3roa7br 63 2 the the DT cord-005146-o3roa7br 63 3 affected affected JJ cord-005146-o3roa7br 63 4 area area NN cord-005146-o3roa7br 63 5 astrocytes astrocyte NNS cord-005146-o3roa7br 63 6 and and CC cord-005146-o3roa7br 63 7 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 63 8 contained contain VBD cord-005146-o3roa7br 63 9 many many JJ cord-005146-o3roa7br 63 10 vacuoles vacuole NNS cord-005146-o3roa7br 63 11 in in IN cord-005146-o3roa7br 63 12 their -PRON- PRP$ cord-005146-o3roa7br 63 13 cytoplasm cytoplasm NN cord-005146-o3roa7br 63 14 suggesting suggest VBG cord-005146-o3roa7br 63 15 early early JJ cord-005146-o3roa7br 63 16 degenerative degenerative JJ cord-005146-o3roa7br 63 17 changes change NNS cord-005146-o3roa7br 63 18 . . . cord-005146-o3roa7br 64 1 The the DT cord-005146-o3roa7br 64 2 vessel vessel NN cord-005146-o3roa7br 64 3 walls wall NNS cord-005146-o3roa7br 64 4 appeared appear VBD cord-005146-o3roa7br 64 5 undamaged undamaged JJ cord-005146-o3roa7br 64 6 and and CC cord-005146-o3roa7br 64 7 no no DT cord-005146-o3roa7br 64 8 haemorrhage haemorrhage NN cord-005146-o3roa7br 64 9 occurred occur VBD cord-005146-o3roa7br 64 10 in in IN cord-005146-o3roa7br 64 11 the the DT cord-005146-o3roa7br 64 12 lesion lesion NN cord-005146-o3roa7br 64 13 . . . cord-005146-o3roa7br 65 1 Light light JJ cord-005146-o3roa7br 65 2 microscopy microscopy NNS cord-005146-o3roa7br 65 3 showed show VBD cord-005146-o3roa7br 65 4 that that IN cord-005146-o3roa7br 65 5 most most JJS cord-005146-o3roa7br 65 6 fibres fibre NNS cord-005146-o3roa7br 65 7 located locate VBN cord-005146-o3roa7br 65 8 near near RB cord-005146-o3roa7br 65 9 to to IN cord-005146-o3roa7br 65 10 the the DT cord-005146-o3roa7br 65 11 pial pial JJ cord-005146-o3roa7br 65 12 surface surface NN cord-005146-o3roa7br 65 13 had have VBD cord-005146-o3roa7br 65 14 myelin myelin NN cord-005146-o3roa7br 65 15 sheaths sheath NNS cord-005146-o3roa7br 65 16 with with IN cord-005146-o3roa7br 65 17 much much RB cord-005146-o3roa7br 65 18 less less JJR cord-005146-o3roa7br 65 19 opacity opacity NN cord-005146-o3roa7br 65 20 , , , cord-005146-o3roa7br 65 21 reflecting reflect VBG cord-005146-o3roa7br 65 22 advanced advanced JJ cord-005146-o3roa7br 65 23 myelin myelin JJ cord-005146-o3roa7br 65 24 lamella lamella NN cord-005146-o3roa7br 65 25 disintegration disintegration NN cord-005146-o3roa7br 65 26 and and CC cord-005146-o3roa7br 65 27 breakdown breakdown NN cord-005146-o3roa7br 65 28 . . . cord-005146-o3roa7br 66 1 Extracellular Extracellular NNP cord-005146-o3roa7br 66 2 spaces space NNS cord-005146-o3roa7br 66 3 between between IN cord-005146-o3roa7br 66 4 the the DT cord-005146-o3roa7br 66 5 axons axon NNS cord-005146-o3roa7br 66 6 were be VBD cord-005146-o3roa7br 66 7 further further RB cord-005146-o3roa7br 66 8 enlarged enlarge VBN cord-005146-o3roa7br 66 9 , , , cord-005146-o3roa7br 66 10 and and CC cord-005146-o3roa7br 66 11 some some DT cord-005146-o3roa7br 66 12 macrophages macrophage NNS cord-005146-o3roa7br 66 13 were be VBD cord-005146-o3roa7br 66 14 found find VBN cord-005146-o3roa7br 66 15 in in IN cord-005146-o3roa7br 66 16 such such JJ cord-005146-o3roa7br 66 17 interaxonal interaxonal JJ cord-005146-o3roa7br 66 18 spaces space NNS cord-005146-o3roa7br 66 19 . . . cord-005146-o3roa7br 67 1 No no DT cord-005146-o3roa7br 67 2 haemorrhage haemorrhage NN cord-005146-o3roa7br 67 3 was be VBD cord-005146-o3roa7br 67 4 noted note VBN cord-005146-o3roa7br 67 5 ( ( -LRB- cord-005146-o3roa7br 67 6 Fig Fig NNP cord-005146-o3roa7br 67 7 . . . cord-005146-o3roa7br 67 8 2C 2C NNP cord-005146-o3roa7br 67 9 ) ) -RRB- cord-005146-o3roa7br 67 10 . . . cord-005146-o3roa7br 68 1 Electron electron NN cord-005146-o3roa7br 68 2 microscopy microscopy NNS cord-005146-o3roa7br 68 3 showed show VBD cord-005146-o3roa7br 68 4 that that IN cord-005146-o3roa7br 68 5 many many JJ cord-005146-o3roa7br 68 6 myelin myelin NN cord-005146-o3roa7br 68 7 sheath sheath NN cord-005146-o3roa7br 68 8 lamellae lamella NNS cord-005146-o3roa7br 68 9 were be VBD cord-005146-o3roa7br 68 10 split split VBN cord-005146-o3roa7br 68 11 extensively extensively RB cord-005146-o3roa7br 68 12 into into IN cord-005146-o3roa7br 68 13 irregularly irregularly RB cord-005146-o3roa7br 68 14 arranged arrange VBN cord-005146-o3roa7br 68 15 sheets sheet NNS cord-005146-o3roa7br 68 16 and and CC cord-005146-o3roa7br 68 17 had have VBD cord-005146-o3roa7br 68 18 partially partially RB cord-005146-o3roa7br 68 19 disintegrated disintegrate VBN cord-005146-o3roa7br 68 20 into into IN cord-005146-o3roa7br 68 21 vesicular vesicular JJ cord-005146-o3roa7br 68 22 structures structure NNS cord-005146-o3roa7br 68 23 , , , cord-005146-o3roa7br 68 24 losing lose VBG cord-005146-o3roa7br 68 25 their -PRON- PRP$ cord-005146-o3roa7br 68 26 original original JJ cord-005146-o3roa7br 68 27 electron electron NN cord-005146-o3roa7br 68 28 Fig fig NN cord-005146-o3roa7br 68 29 . . . cord-005146-o3roa7br 69 1 4 4 LS cord-005146-o3roa7br 69 2 . . . cord-005146-o3roa7br 70 1 Three three CD cord-005146-o3roa7br 70 2 days day NNS cord-005146-o3roa7br 70 3 after after IN cord-005146-o3roa7br 70 4 treatment treatment NN cord-005146-o3roa7br 70 5 . . . cord-005146-o3roa7br 71 1 This this DT cord-005146-o3roa7br 71 2 electron electron NN cord-005146-o3roa7br 71 3 micrograph micrograph NN cord-005146-o3roa7br 71 4 shows show VBZ cord-005146-o3roa7br 71 5 a a DT cord-005146-o3roa7br 71 6 later later JJ cord-005146-o3roa7br 71 7 stage stage NN cord-005146-o3roa7br 71 8 in in IN cord-005146-o3roa7br 71 9 myelin myelin NN cord-005146-o3roa7br 71 10 sheath sheath NN cord-005146-o3roa7br 71 11 degradation degradation NN cord-005146-o3roa7br 71 12 with with IN cord-005146-o3roa7br 71 13 interlamellar interlamellar JJ cord-005146-o3roa7br 71 14 splitting splitting NN cord-005146-o3roa7br 71 15 of of IN cord-005146-o3roa7br 71 16 all all PDT cord-005146-o3roa7br 71 17 the the DT cord-005146-o3roa7br 71 18 fibres fibre NNS cord-005146-o3roa7br 71 19 . . . cord-005146-o3roa7br 72 1 Some some DT cord-005146-o3roa7br 72 2 axons axon NNS cord-005146-o3roa7br 72 3 ( ( -LRB- cord-005146-o3roa7br 72 4 asterisk asterisk NN cord-005146-o3roa7br 72 5 ) ) -RRB- cord-005146-o3roa7br 72 6 appear appear VBP cord-005146-o3roa7br 72 7 to to TO cord-005146-o3roa7br 72 8 have have VB cord-005146-o3roa7br 72 9 been be VBN cord-005146-o3roa7br 72 10 damaged damage VBN cord-005146-o3roa7br 72 11 by by IN cord-005146-o3roa7br 72 12 heat heat NN cord-005146-o3roa7br 72 13 injury injury NN cord-005146-o3roa7br 72 14 , , , cord-005146-o3roa7br 72 15 but but CC cord-005146-o3roa7br 72 16 most most JJS cord-005146-o3roa7br 72 17 seem seem VBP cord-005146-o3roa7br 72 18 to to TO cord-005146-o3roa7br 72 19 be be VB cord-005146-o3roa7br 72 20 intact intact JJ cord-005146-o3roa7br 73 1 ( ( -LRB- cord-005146-o3roa7br 73 2 Ax Ax NNP cord-005146-o3roa7br 73 3 ) ) -RRB- cord-005146-o3roa7br 73 4 . . . cord-005146-o3roa7br 74 1 Astrocytes Astrocytes NNP cord-005146-o3roa7br 74 2 at at IN cord-005146-o3roa7br 74 3 the the DT cord-005146-o3roa7br 74 4 GLM GLM NNP cord-005146-o3roa7br 74 5 beneath beneath IN cord-005146-o3roa7br 74 6 the the DT cord-005146-o3roa7br 74 7 pia pia NNP cord-005146-o3roa7br 74 8 are be VBP cord-005146-o3roa7br 74 9 totally totally RB cord-005146-o3roa7br 74 10 destroyed destroy VBN cord-005146-o3roa7br 74 11 , , , cord-005146-o3roa7br 74 12 but but CC cord-005146-o3roa7br 74 13 the the DT cord-005146-o3roa7br 74 14 basal basal NN cord-005146-o3roa7br 74 15 laminae laminae NNP cord-005146-o3roa7br 74 16 are be VBP cord-005146-o3roa7br 74 17 largely largely RB cord-005146-o3roa7br 74 18 preserved preserve VBN cord-005146-o3roa7br 74 19 ( ( -LRB- cord-005146-o3roa7br 74 20 arrowheads arrowhead NNS cord-005146-o3roa7br 74 21 ) ) -RRB- cord-005146-o3roa7br 74 22 . . . cord-005146-o3roa7br 75 1 Extracellular Extracellular NNP cord-005146-o3roa7br 75 2 spaces space NNS cord-005146-o3roa7br 75 3 of of IN cord-005146-o3roa7br 75 4 the the DT cord-005146-o3roa7br 75 5 affected affected JJ cord-005146-o3roa7br 75 6 area area NN cord-005146-o3roa7br 75 7 have have VBP cord-005146-o3roa7br 75 8 become become VBN cord-005146-o3roa7br 75 9 much much RB cord-005146-o3roa7br 75 10 more more RBR cord-005146-o3roa7br 75 11 conspicuous conspicuous JJ cord-005146-o3roa7br 75 12 than than IN cord-005146-o3roa7br 75 13 in in IN cord-005146-o3roa7br 75 14 Fig Fig NNP cord-005146-o3roa7br 75 15 . . . cord-005146-o3roa7br 76 1 3 3 LS cord-005146-o3roa7br 76 2 . . . cord-005146-o3roa7br 77 1 x x LS cord-005146-o3roa7br 77 2 8600 8600 CD cord-005146-o3roa7br 77 3 . . . cord-005146-o3roa7br 78 1 opacity opacity NNP cord-005146-o3roa7br 78 2 ( ( -LRB- cord-005146-o3roa7br 78 3 Fig Fig NNP cord-005146-o3roa7br 78 4 . . . cord-005146-o3roa7br 78 5 4 4 CD cord-005146-o3roa7br 78 6 ) ) -RRB- cord-005146-o3roa7br 78 7 . . . cord-005146-o3roa7br 79 1 Other other JJ cord-005146-o3roa7br 79 2 myelin myelin NN cord-005146-o3roa7br 79 3 sheaths sheath NNS cord-005146-o3roa7br 79 4 , , , cord-005146-o3roa7br 79 5 while while IN cord-005146-o3roa7br 79 6 retaining retain VBG cord-005146-o3roa7br 79 7 densely densely RB cord-005146-o3roa7br 79 8 packed pack VBN cord-005146-o3roa7br 79 9 lamellae lamella NNS cord-005146-o3roa7br 79 10 , , , cord-005146-o3roa7br 79 11 exhibited exhibit VBD cord-005146-o3roa7br 79 12 a a DT cord-005146-o3roa7br 79 13 greatly greatly RB cord-005146-o3roa7br 79 14 decreased decrease VBN cord-005146-o3roa7br 79 15 electron electron NN cord-005146-o3roa7br 79 16 opacity opacity NN cord-005146-o3roa7br 79 17 . . . cord-005146-o3roa7br 80 1 Axons axon NNS cord-005146-o3roa7br 80 2 whose whose WP$ cord-005146-o3roa7br 80 3 myelin myelin NN cord-005146-o3roa7br 80 4 sheaths sheath NNS cord-005146-o3roa7br 80 5 had have VBD cord-005146-o3roa7br 80 6 become become VBN cord-005146-o3roa7br 80 7 degraded degrade VBN cord-005146-o3roa7br 80 8 appeared appear VBD cord-005146-o3roa7br 80 9 normal normal JJ cord-005146-o3roa7br 80 10 . . . cord-005146-o3roa7br 81 1 Astrocyte Astrocyte NNP cord-005146-o3roa7br 81 2 processes process VBZ cord-005146-o3roa7br 81 3 including include VBG cord-005146-o3roa7br 81 4 endfeet endfeet NNP cord-005146-o3roa7br 81 5 of of IN cord-005146-o3roa7br 81 6 the the DT cord-005146-o3roa7br 81 7 GLM GLM NNP cord-005146-o3roa7br 81 8 were be VBD cord-005146-o3roa7br 81 9 entirely entirely RB cord-005146-o3roa7br 81 10 disrupted disrupt VBN cord-005146-o3roa7br 81 11 and and CC cord-005146-o3roa7br 81 12 were be VBD cord-005146-o3roa7br 81 13 not not RB cord-005146-o3roa7br 81 14 visible visible JJ cord-005146-o3roa7br 81 15 . . . cord-005146-o3roa7br 82 1 However however RB cord-005146-o3roa7br 82 2 , , , cord-005146-o3roa7br 82 3 the the DT cord-005146-o3roa7br 82 4 basal basal NN cord-005146-o3roa7br 82 5 laminae laminae NN cord-005146-o3roa7br 82 6 of of IN cord-005146-o3roa7br 82 7 the the DT cord-005146-o3roa7br 82 8 GLM GLM NNP cord-005146-o3roa7br 82 9 remained remain VBD cord-005146-o3roa7br 82 10 intact intact JJ cord-005146-o3roa7br 82 11 separating separate VBG cord-005146-o3roa7br 82 12 the the DT cord-005146-o3roa7br 82 13 CNS CNS NNP cord-005146-o3roa7br 82 14 from from IN cord-005146-o3roa7br 82 15 the the DT cord-005146-o3roa7br 82 16 s s NNP cord-005146-o3roa7br 82 17 u u NN cord-005146-o3roa7br 82 18 r r NN cord-005146-o3roa7br 82 19 r r NN cord-005146-o3roa7br 82 20 o o NN cord-005146-o3roa7br 82 21 u u NN cord-005146-o3roa7br 82 22 n n NN cord-005146-o3roa7br 82 23 d d NNP cord-005146-o3roa7br 82 24 i i NNP cord-005146-o3roa7br 82 25 n n NN cord-005146-o3roa7br 82 26 g g NN cord-005146-o3roa7br 82 27 c c NN cord-005146-o3roa7br 82 28 o o NN cord-005146-o3roa7br 82 29 n n NN cord-005146-o3roa7br 83 1 n n NN cord-005146-o3roa7br 83 2 e e NN cord-005146-o3roa7br 83 3 c c NN cord-005146-o3roa7br 84 1 t t NNP cord-005146-o3roa7br 85 1 i i PRP cord-005146-o3roa7br 85 2 v v NN cord-005146-o3roa7br 85 3 e e DT cord-005146-o3roa7br 85 4 tissue tissue NN cord-005146-o3roa7br 85 5 . . . cord-005146-o3roa7br 86 1 No no DT cord-005146-o3roa7br 86 2 oligodendrocyte oligodendrocyte NNP cord-005146-o3roa7br 86 3 cell cell NN cord-005146-o3roa7br 86 4 bodies body NNS cord-005146-o3roa7br 86 5 or or CC cord-005146-o3roa7br 86 6 processes process NNS cord-005146-o3roa7br 86 7 were be VBD cord-005146-o3roa7br 86 8 found find VBN cord-005146-o3roa7br 86 9 in in IN cord-005146-o3roa7br 86 10 the the DT cord-005146-o3roa7br 86 11 areas area NNS cord-005146-o3roa7br 86 12 near near IN cord-005146-o3roa7br 86 13 the the DT cord-005146-o3roa7br 86 14 surface surface NN cord-005146-o3roa7br 86 15 or or CC cord-005146-o3roa7br 86 16 in in IN cord-005146-o3roa7br 86 17 the the DT cord-005146-o3roa7br 86 18 centre centre NN cord-005146-o3roa7br 86 19 of of IN cord-005146-o3roa7br 86 20 the the DT cord-005146-o3roa7br 86 21 lesion lesion NN cord-005146-o3roa7br 86 22 . . . cord-005146-o3roa7br 87 1 Fragments fragment NNS cord-005146-o3roa7br 87 2 of of IN cord-005146-o3roa7br 87 3 degraded degraded JJ cord-005146-o3roa7br 87 4 myelin myelin NN cord-005146-o3roa7br 87 5 sheaths sheath NNS cord-005146-o3roa7br 87 6 , , , cord-005146-o3roa7br 87 7 as as RB cord-005146-o3roa7br 87 8 well well RB cord-005146-o3roa7br 87 9 as as IN cord-005146-o3roa7br 87 10 fibrin fibrin NN cord-005146-o3roa7br 87 11 , , , cord-005146-o3roa7br 87 12 were be VBD cord-005146-o3roa7br 87 13 scattered scatter VBN cord-005146-o3roa7br 87 14 in in IN cord-005146-o3roa7br 87 15 wide wide JJ cord-005146-o3roa7br 87 16 interaxonal interaxonal JJ cord-005146-o3roa7br 87 17 spaces space NNS cord-005146-o3roa7br 87 18 , , , cord-005146-o3roa7br 87 19 and and CC cord-005146-o3roa7br 87 20 macrophages macrophage NNS cord-005146-o3roa7br 87 21 were be VBD cord-005146-o3roa7br 87 22 phagocytosing phagocytose VBG cord-005146-o3roa7br 87 23 cellular cellular JJ cord-005146-o3roa7br 87 24 debris debris NN cord-005146-o3roa7br 87 25 . . . cord-005146-o3roa7br 88 1 N N NNP cord-005146-o3roa7br 89 1 u u NNP cord-005146-o3roa7br 89 2 m m NNP cord-005146-o3roa7br 90 1 e e LS cord-005146-o3roa7br 90 2 r r NNP cord-005146-o3roa7br 91 1 o o UH cord-005146-o3roa7br 92 1 u u NNP cord-005146-o3roa7br 92 2 s s NNP cord-005146-o3roa7br 93 1 d d NNP cord-005146-o3roa7br 94 1 e e LS cord-005146-o3roa7br 94 2 n n NNP cord-005146-o3roa7br 94 3 u u NNP cord-005146-o3roa7br 94 4 d d NN cord-005146-o3roa7br 94 5 e e NNP cord-005146-o3roa7br 94 6 d d NNP cord-005146-o3roa7br 94 7 axons axon NNS cord-005146-o3roa7br 94 8 were be VBD cord-005146-o3roa7br 94 9 identified identify VBN cord-005146-o3roa7br 94 10 by by IN cord-005146-o3roa7br 94 11 light light JJ cord-005146-o3roa7br 94 12 microscopy microscopy NNS cord-005146-o3roa7br 94 13 as as IN cord-005146-o3roa7br 94 14 various various JJ cord-005146-o3roa7br 94 15 - - HYPH cord-005146-o3roa7br 94 16 sized sized JJ cord-005146-o3roa7br 94 17 bundles bundle NNS cord-005146-o3roa7br 94 18 within within IN cord-005146-o3roa7br 94 19 the the DT cord-005146-o3roa7br 94 20 heat heat NN cord-005146-o3roa7br 94 21 - - HYPH cord-005146-o3roa7br 94 22 injured injure VBN cord-005146-o3roa7br 94 23 areas area NNS cord-005146-o3roa7br 94 24 . . . cord-005146-o3roa7br 95 1 Macrophages macrophage NNS cord-005146-o3roa7br 95 2 containing contain VBG cord-005146-o3roa7br 95 3 myelin myelin NN cord-005146-o3roa7br 95 4 debris debris NN cord-005146-o3roa7br 95 5 were be VBD cord-005146-o3roa7br 95 6 scattered scatter VBN cord-005146-o3roa7br 95 7 between between IN cord-005146-o3roa7br 95 8 such such JJ cord-005146-o3roa7br 95 9 d d NN cord-005146-o3roa7br 95 10 e e NN cord-005146-o3roa7br 95 11 n n NN cord-005146-o3roa7br 95 12 u u NNP cord-005146-o3roa7br 95 13 d d NNP cord-005146-o3roa7br 95 14 e e NN cord-005146-o3roa7br 95 15 d d NNP cord-005146-o3roa7br 95 16 axons axon NNS cord-005146-o3roa7br 95 17 . . . cord-005146-o3roa7br 96 1 Spindle spindle NN cord-005146-o3roa7br 96 2 - - HYPH cord-005146-o3roa7br 96 3 shaped shape VBN cord-005146-o3roa7br 96 4 cells cell NNS cord-005146-o3roa7br 96 5 proliferated proliferate VBD cord-005146-o3roa7br 96 6 and and CC cord-005146-o3roa7br 96 7 made make VBD cord-005146-o3roa7br 96 8 a a DT cord-005146-o3roa7br 96 9 dense dense JJ cord-005146-o3roa7br 96 10 cell cell NN cord-005146-o3roa7br 96 11 layer layer NN cord-005146-o3roa7br 96 12 above above IN cord-005146-o3roa7br 96 13 the the DT cord-005146-o3roa7br 96 14 affected affected JJ cord-005146-o3roa7br 96 15 area area NN cord-005146-o3roa7br 97 1 ( ( -LRB- cord-005146-o3roa7br 97 2 Fig Fig NNP cord-005146-o3roa7br 97 3 . . . cord-005146-o3roa7br 97 4 2D 2D NNP cord-005146-o3roa7br 97 5 ) ) -RRB- cord-005146-o3roa7br 97 6 . . . cord-005146-o3roa7br 98 1 By by IN cord-005146-o3roa7br 98 2 electron electron NN cord-005146-o3roa7br 98 3 microscopy microscopy NN cord-005146-o3roa7br 98 4 almost almost RB cord-005146-o3roa7br 98 5 all all DT cord-005146-o3roa7br 98 6 axons axon NNS cord-005146-o3roa7br 98 7 were be VBD cord-005146-o3roa7br 98 8 completely completely RB cord-005146-o3roa7br 98 9 demyelinated demyelinate VBN cord-005146-o3roa7br 98 10 and and CC cord-005146-o3roa7br 98 11 closely closely RB cord-005146-o3roa7br 98 12 packed packed JJ cord-005146-o3roa7br 98 13 ( ( -LRB- cord-005146-o3roa7br 98 14 Fig fig NN cord-005146-o3roa7br 98 15 . . . cord-005146-o3roa7br 98 16 5A 5a CD cord-005146-o3roa7br 98 17 ) ) -RRB- cord-005146-o3roa7br 98 18 . . . cord-005146-o3roa7br 99 1 A a DT cord-005146-o3roa7br 99 2 notable notable JJ cord-005146-o3roa7br 99 3 finding finding NN cord-005146-o3roa7br 99 4 was be VBD cord-005146-o3roa7br 99 5 the the DT cord-005146-o3roa7br 99 6 presence presence NN cord-005146-o3roa7br 99 7 , , , cord-005146-o3roa7br 99 8 between between IN cord-005146-o3roa7br 99 9 the the DT cord-005146-o3roa7br 99 10 demyelinated demyelinate VBN cord-005146-o3roa7br 99 11 axons axon NNS cord-005146-o3roa7br 99 12 , , , cord-005146-o3roa7br 99 13 of of IN cord-005146-o3roa7br 99 14 cells cell NNS cord-005146-o3roa7br 99 15 with with IN cord-005146-o3roa7br 99 16 round round JJ cord-005146-o3roa7br 99 17 nuclei nucleus NNS cord-005146-o3roa7br 99 18 which which WDT cord-005146-o3roa7br 99 19 contained contain VBD cord-005146-o3roa7br 99 20 no no DT cord-005146-o3roa7br 99 21 myelin myelin JJ cord-005146-o3roa7br 99 22 debris debris NN cord-005146-o3roa7br 99 23 . . . cord-005146-o3roa7br 100 1 These these DT cord-005146-o3roa7br 100 2 cells cell NNS cord-005146-o3roa7br 100 3 often often RB cord-005146-o3roa7br 100 4 extended extend VBD cord-005146-o3roa7br 100 5 cytoplasmic cytoplasmic JJ cord-005146-o3roa7br 100 6 processes process NNS cord-005146-o3roa7br 100 7 around around IN cord-005146-o3roa7br 100 8 axons axon NNS cord-005146-o3roa7br 100 9 in in IN cord-005146-o3roa7br 100 10 the the DT cord-005146-o3roa7br 100 11 m m NNP cord-005146-o3roa7br 100 12 a a NNP cord-005146-o3roa7br 100 13 n n NN cord-005146-o3roa7br 100 14 n n NN cord-005146-o3roa7br 100 15 e e NN cord-005146-o3roa7br 100 16 r r NN cord-005146-o3roa7br 100 17 of of IN cord-005146-o3roa7br 100 18 developing develop VBG cord-005146-o3roa7br 100 19 Schwann Schwann NNP cord-005146-o3roa7br 100 20 and and CC cord-005146-o3roa7br 100 21 glial glial JJ cord-005146-o3roa7br 100 22 cells cell NNS cord-005146-o3roa7br 100 23 , , , cord-005146-o3roa7br 100 24 suggesting suggest VBG cord-005146-o3roa7br 100 25 that that IN cord-005146-o3roa7br 100 26 they -PRON- PRP cord-005146-o3roa7br 100 27 were be VBD cord-005146-o3roa7br 100 28 immature immature JJ cord-005146-o3roa7br 100 29 Schwann Schwann NNP cord-005146-o3roa7br 100 30 or or CC cord-005146-o3roa7br 100 31 glial glial JJ cord-005146-o3roa7br 100 32 cells cell NNS cord-005146-o3roa7br 100 33 migrating migrate VBG cord-005146-o3roa7br 100 34 through through IN cord-005146-o3roa7br 100 35 the the DT cord-005146-o3roa7br 100 36 interaxonal interaxonal JJ cord-005146-o3roa7br 100 37 spaces space NNS cord-005146-o3roa7br 100 38 ( ( -LRB- cord-005146-o3roa7br 100 39 Fig Fig NNP cord-005146-o3roa7br 100 40 . . . cord-005146-o3roa7br 100 41 5B 5b CD cord-005146-o3roa7br 100 42 ) ) -RRB- cord-005146-o3roa7br 100 43 . . . cord-005146-o3roa7br 101 1 Cells cell NNS cord-005146-o3roa7br 101 2 identifiable identifiable JJ cord-005146-o3roa7br 101 3 as as IN cord-005146-o3roa7br 101 4 astrocytes astrocyte NNS cord-005146-o3roa7br 101 5 and and CC cord-005146-o3roa7br 101 6 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 101 7 were be VBD cord-005146-o3roa7br 101 8 not not RB cord-005146-o3roa7br 101 9 observed observe VBN cord-005146-o3roa7br 101 10 within within IN cord-005146-o3roa7br 101 11 the the DT cord-005146-o3roa7br 101 12 affected affected JJ cord-005146-o3roa7br 101 13 area area NN cord-005146-o3roa7br 101 14 at at IN cord-005146-o3roa7br 101 15 this this DT cord-005146-o3roa7br 101 16 time time NN cord-005146-o3roa7br 101 17 . . . cord-005146-o3roa7br 102 1 The the DT cord-005146-o3roa7br 102 2 GLM GLM NNP cord-005146-o3roa7br 102 3 basal basal NN cord-005146-o3roa7br 102 4 lamina lamina NN cord-005146-o3roa7br 102 5 at at IN cord-005146-o3roa7br 102 6 the the DT cord-005146-o3roa7br 102 7 pial pial JJ cord-005146-o3roa7br 102 8 surface surface NN cord-005146-o3roa7br 102 9 was be VBD cord-005146-o3roa7br 102 10 largely largely RB cord-005146-o3roa7br 102 11 destroyed destroy VBN cord-005146-o3roa7br 102 12 . . . cord-005146-o3roa7br 103 1 Thus thus RB cord-005146-o3roa7br 103 2 naked naked JJ cord-005146-o3roa7br 103 3 axons axon NNS cord-005146-o3roa7br 103 4 and and CC cord-005146-o3roa7br 103 5 associated associated JJ cord-005146-o3roa7br 103 6 imma imma NN cord-005146-o3roa7br 103 7 - - HYPH cord-005146-o3roa7br 103 8 ture ture NN cord-005146-o3roa7br 103 9 Schwann Schwann NNP cord-005146-o3roa7br 103 10 cells cell NNS cord-005146-o3roa7br 103 11 were be VBD cord-005146-o3roa7br 103 12 in in IN cord-005146-o3roa7br 103 13 direct direct JJ cord-005146-o3roa7br 103 14 contact contact NN cord-005146-o3roa7br 103 15 with with IN cord-005146-o3roa7br 103 16 the the DT cord-005146-o3roa7br 103 17 pial pial JJ cord-005146-o3roa7br 103 18 connective connective JJ cord-005146-o3roa7br 103 19 tissues tissue NNS cord-005146-o3roa7br 103 20 at at IN cord-005146-o3roa7br 103 21 the the DT cord-005146-o3roa7br 103 22 pial pial JJ cord-005146-o3roa7br 103 23 surface surface NN cord-005146-o3roa7br 103 24 . . . cord-005146-o3roa7br 104 1 Spindle spindle NN cord-005146-o3roa7br 104 2 - - HYPH cord-005146-o3roa7br 104 3 shaped shape VBN cord-005146-o3roa7br 104 4 non non JJ cord-005146-o3roa7br 104 5 - - JJ cord-005146-o3roa7br 104 6 neural neural JJ cord-005146-o3roa7br 104 7 cells cell NNS cord-005146-o3roa7br 104 8 were be VBD cord-005146-o3roa7br 104 9 numerous numerous JJ cord-005146-o3roa7br 104 10 throughout throughout IN cord-005146-o3roa7br 104 11 the the DT cord-005146-o3roa7br 104 12 pial pial JJ cord-005146-o3roa7br 104 13 layer layer NN cord-005146-o3roa7br 104 14 . . . cord-005146-o3roa7br 105 1 Most Most JJS cord-005146-o3roa7br 105 2 axons axon NNS cord-005146-o3roa7br 105 3 near near IN cord-005146-o3roa7br 105 4 the the DT cord-005146-o3roa7br 105 5 pial pial JJ cord-005146-o3roa7br 105 6 surface surface NN cord-005146-o3roa7br 105 7 appeared appear VBD cord-005146-o3roa7br 105 8 thinly thinly RB cord-005146-o3roa7br 105 9 myelinated myelinate VBN cord-005146-o3roa7br 105 10 by by IN cord-005146-o3roa7br 105 11 light light JJ cord-005146-o3roa7br 105 12 microscopy microscopy NNS cord-005146-o3roa7br 105 13 , , , cord-005146-o3roa7br 105 14 while while IN cord-005146-o3roa7br 105 15 most most JJS cord-005146-o3roa7br 105 16 axons axon NNS cord-005146-o3roa7br 105 17 located locate VBN cord-005146-o3roa7br 105 18 toward toward IN cord-005146-o3roa7br 105 19 the the DT cord-005146-o3roa7br 105 20 deep deep JJ cord-005146-o3roa7br 105 21 or or CC cord-005146-o3roa7br 105 22 marginal marginal JJ cord-005146-o3roa7br 105 23 zones zone NNS cord-005146-o3roa7br 105 24 of of IN cord-005146-o3roa7br 105 25 the the DT cord-005146-o3roa7br 105 26 lesion lesion NN cord-005146-o3roa7br 105 27 remained remain VBD cord-005146-o3roa7br 105 28 denuded denuded JJ cord-005146-o3roa7br 105 29 . . . cord-005146-o3roa7br 106 1 Also also RB cord-005146-o3roa7br 106 2 noted note VBN cord-005146-o3roa7br 106 3 were be VBD cord-005146-o3roa7br 106 4 many many JJ cord-005146-o3roa7br 106 5 round round JJ cord-005146-o3roa7br 106 6 cells cell NNS cord-005146-o3roa7br 106 7 with with IN cord-005146-o3roa7br 106 8 relatively relatively RB cord-005146-o3roa7br 106 9 dark dark JJ cord-005146-o3roa7br 106 10 cytoplasm cytoplasm NN cord-005146-o3roa7br 106 11 , , , cord-005146-o3roa7br 106 12 intimately intimately RB cord-005146-o3roa7br 106 13 associated associate VBN cord-005146-o3roa7br 106 14 with with IN cord-005146-o3roa7br 106 15 the the DT cord-005146-o3roa7br 106 16 thinly thinly RB cord-005146-o3roa7br 106 17 myelinated myelinated JJ cord-005146-o3roa7br 106 18 axons axon NNS cord-005146-o3roa7br 106 19 . . . cord-005146-o3roa7br 107 1 Spindleshaped spindleshape VBN cord-005146-o3roa7br 107 2 non non JJ cord-005146-o3roa7br 107 3 - - JJ cord-005146-o3roa7br 107 4 neuronal neuronal JJ cord-005146-o3roa7br 107 5 cells cell NNS cord-005146-o3roa7br 107 6 and and CC cord-005146-o3roa7br 107 7 bundles bundle NNS cord-005146-o3roa7br 107 8 of of IN cord-005146-o3roa7br 107 9 collagen collagen NN cord-005146-o3roa7br 107 10 fibres fibre NNS cord-005146-o3roa7br 107 11 formed form VBD cord-005146-o3roa7br 107 12 a a DT cord-005146-o3roa7br 107 13 thick thick JJ cord-005146-o3roa7br 107 14 pial pial JJ cord-005146-o3roa7br 107 15 layer layer NN cord-005146-o3roa7br 107 16 on on IN cord-005146-o3roa7br 107 17 the the DT cord-005146-o3roa7br 107 18 surface surface NN cord-005146-o3roa7br 107 19 of of IN cord-005146-o3roa7br 107 20 the the DT cord-005146-o3roa7br 107 21 injured injure VBN cord-005146-o3roa7br 107 22 cord cord NN cord-005146-o3roa7br 107 23 . . . cord-005146-o3roa7br 108 1 Macrophages macrophage NNS cord-005146-o3roa7br 108 2 containing contain VBG cord-005146-o3roa7br 108 3 myelin myelin NN cord-005146-o3roa7br 108 4 debris debris NN cord-005146-o3roa7br 108 5 were be VBD cord-005146-o3roa7br 108 6 still still RB cord-005146-o3roa7br 108 7 present present JJ cord-005146-o3roa7br 108 8 in in IN cord-005146-o3roa7br 108 9 the the DT cord-005146-o3roa7br 108 10 lesion lesion NN cord-005146-o3roa7br 108 11 ( ( -LRB- cord-005146-o3roa7br 108 12 Fig Fig NNP cord-005146-o3roa7br 108 13 . . . cord-005146-o3roa7br 108 14 2E 2E NNP cord-005146-o3roa7br 108 15 ) ) -RRB- cord-005146-o3roa7br 108 16 . . . cord-005146-o3roa7br 109 1 By by IN cord-005146-o3roa7br 109 2 electron electron NN cord-005146-o3roa7br 109 3 microscopy microscopy NNS cord-005146-o3roa7br 109 4 , , , cord-005146-o3roa7br 109 5 many many JJ cord-005146-o3roa7br 109 6 axons axon NNS cord-005146-o3roa7br 109 7 were be VBD cord-005146-o3roa7br 109 8 noted note VBN cord-005146-o3roa7br 109 9 near near IN cord-005146-o3roa7br 109 10 the the DT cord-005146-o3roa7br 109 11 pial pial JJ cord-005146-o3roa7br 109 12 surface surface NN cord-005146-o3roa7br 109 13 covered cover VBN cord-005146-o3roa7br 109 14 mostly mostly RB cord-005146-o3roa7br 109 15 by by IN cord-005146-o3roa7br 109 16 very very RB cord-005146-o3roa7br 109 17 thin thin JJ cord-005146-o3roa7br 109 18 , , , cord-005146-o3roa7br 109 19 but but CC cord-005146-o3roa7br 109 20 occasionally occasionally RB cord-005146-o3roa7br 109 21 by by IN cord-005146-o3roa7br 109 22 relatively relatively RB cord-005146-o3roa7br 109 23 thick thick JJ cord-005146-o3roa7br 109 24 myelin myelin NN cord-005146-o3roa7br 109 25 sheaths sheath NNS cord-005146-o3roa7br 109 26 ( ( -LRB- cord-005146-o3roa7br 109 27 Fig fig NN cord-005146-o3roa7br 109 28 . . . cord-005146-o3roa7br 109 29 6 6 CD cord-005146-o3roa7br 109 30 ) ) -RRB- cord-005146-o3roa7br 109 31 . . . cord-005146-o3roa7br 110 1 It -PRON- PRP cord-005146-o3roa7br 110 2 was be VBD cord-005146-o3roa7br 110 3 evident evident JJ cord-005146-o3roa7br 110 4 that that IN cord-005146-o3roa7br 110 5 the the DT cord-005146-o3roa7br 110 6 round round JJ cord-005146-o3roa7br 110 7 cells cell NNS cord-005146-o3roa7br 110 8 were be VBD cord-005146-o3roa7br 110 9 associated associate VBN cord-005146-o3roa7br 110 10 1 1 CD cord-005146-o3roa7br 110 11 : : SYM cord-005146-o3roa7br 110 12 1 1 CD cord-005146-o3roa7br 110 13 with with IN cord-005146-o3roa7br 110 14 the the DT cord-005146-o3roa7br 110 15 axons axon NNS cord-005146-o3roa7br 110 16 , , , cord-005146-o3roa7br 110 17 and and CC cord-005146-o3roa7br 110 18 that that IN cord-005146-o3roa7br 110 19 they -PRON- PRP cord-005146-o3roa7br 110 20 were be VBD cord-005146-o3roa7br 110 21 covered cover VBN cord-005146-o3roa7br 110 22 by by IN cord-005146-o3roa7br 110 23 basal basal NN cord-005146-o3roa7br 110 24 lamina lamina NNP cord-005146-o3roa7br 110 25 , , , cord-005146-o3roa7br 110 26 features feature VBZ cord-005146-o3roa7br 110 27 typical typical JJ cord-005146-o3roa7br 110 28 of of IN cord-005146-o3roa7br 110 29 myelinating myelinate VBG cord-005146-o3roa7br 110 30 Schwann Schwann NNP cord-005146-o3roa7br 110 31 cells cell NNS cord-005146-o3roa7br 110 32 . . . cord-005146-o3roa7br 111 1 In in IN cord-005146-o3roa7br 111 2 the the DT cord-005146-o3roa7br 111 3 marginal marginal JJ cord-005146-o3roa7br 111 4 zone zone NN cord-005146-o3roa7br 111 5 bordering border VBG cord-005146-o3roa7br 111 6 the the DT cord-005146-o3roa7br 111 7 intact intact JJ cord-005146-o3roa7br 111 8 area area NN cord-005146-o3roa7br 111 9 , , , cord-005146-o3roa7br 111 10 some some DT cord-005146-o3roa7br 111 11 axons axon NNS cord-005146-o3roa7br 111 12 were be VBD cord-005146-o3roa7br 111 13 thinly thinly RB cord-005146-o3roa7br 111 14 myelinated myelinate VBN cord-005146-o3roa7br 111 15 by by IN cord-005146-o3roa7br 111 16 oligodendrocyte oligodendrocyte NNP cord-005146-o3roa7br 111 17 processes process NNS cord-005146-o3roa7br 112 1 ( ( -LRB- cord-005146-o3roa7br 112 2 Fig Fig NNP cord-005146-o3roa7br 112 3 . . . cord-005146-o3roa7br 113 1 7 7 LS cord-005146-o3roa7br 113 2 ) ) -RRB- cord-005146-o3roa7br 113 3 : : : cord-005146-o3roa7br 113 4 the the DT cord-005146-o3roa7br 113 5 myelin myelin NN cord-005146-o3roa7br 113 6 sheath sheath NN cord-005146-o3roa7br 113 7 had have VBD cord-005146-o3roa7br 113 8 an an DT cord-005146-o3roa7br 113 9 interlamellar interlamellar JJ cord-005146-o3roa7br 113 10 periodicity periodicity NN cord-005146-o3roa7br 113 11 of of IN cord-005146-o3roa7br 113 12 about about IN cord-005146-o3roa7br 113 13 130A. 130a. NN cord-005146-o3roa7br 114 1 At at IN cord-005146-o3roa7br 114 2 this this DT cord-005146-o3roa7br 114 3 stage stage NN cord-005146-o3roa7br 114 4 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 114 5 tended tend VBD cord-005146-o3roa7br 114 6 to to TO cord-005146-o3roa7br 114 7 be be VB cord-005146-o3roa7br 114 8 in in IN cord-005146-o3roa7br 114 9 contact contact NN cord-005146-o3roa7br 114 10 with with IN cord-005146-o3roa7br 114 11 or or CC cord-005146-o3roa7br 114 12 near near IN cord-005146-o3roa7br 114 13 these these DT cord-005146-o3roa7br 114 14 CNS CNS NNP cord-005146-o3roa7br 114 15 - - HYPH cord-005146-o3roa7br 114 16 type type NN cord-005146-o3roa7br 114 17 fibres fibre NNS cord-005146-o3roa7br 114 18 . . . cord-005146-o3roa7br 115 1 Astrocytes Astrocytes NNP cord-005146-o3roa7br 115 2 also also RB cord-005146-o3roa7br 115 3 appeared appear VBD cord-005146-o3roa7br 115 4 in in IN cord-005146-o3roa7br 115 5 the the DT cord-005146-o3roa7br 115 6 marginal marginal JJ cord-005146-o3roa7br 115 7 zone zone NN cord-005146-o3roa7br 115 8 bordering border VBG cord-005146-o3roa7br 115 9 the the DT cord-005146-o3roa7br 115 10 intact intact JJ cord-005146-o3roa7br 115 11 area area NN cord-005146-o3roa7br 115 12 . . . cord-005146-o3roa7br 116 1 By by IN cord-005146-o3roa7br 116 2 light light JJ cord-005146-o3roa7br 116 3 microscopy microscopy NNS cord-005146-o3roa7br 116 4 it -PRON- PRP cord-005146-o3roa7br 116 5 was be VBD cord-005146-o3roa7br 116 6 determined determine VBN cord-005146-o3roa7br 116 7 that that IN cord-005146-o3roa7br 116 8 almost almost RB cord-005146-o3roa7br 116 9 all all PDT cord-005146-o3roa7br 116 10 the the DT cord-005146-o3roa7br 116 11 axons axon NNS cord-005146-o3roa7br 116 12 located locate VBN cord-005146-o3roa7br 116 13 near near IN cord-005146-o3roa7br 116 14 the the DT cord-005146-o3roa7br 116 15 pial pial JJ cord-005146-o3roa7br 116 16 and and CC cord-005146-o3roa7br 116 17 perivascular perivascular JJ cord-005146-o3roa7br 116 18 surfaces surface NNS cord-005146-o3roa7br 116 19 were be VBD cord-005146-o3roa7br 116 20 covered cover VBN cord-005146-o3roa7br 116 21 by by IN cord-005146-o3roa7br 116 22 thick thick JJ cord-005146-o3roa7br 116 23 myelin myelin JJ cord-005146-o3roa7br 116 24 sheaths sheath NNS cord-005146-o3roa7br 116 25 . . . cord-005146-o3roa7br 117 1 Schwann Schwann NNP cord-005146-o3roa7br 117 2 cells cell NNS cord-005146-o3roa7br 117 3 were be VBD cord-005146-o3roa7br 117 4 associated associate VBN cord-005146-o3roa7br 117 5 with with IN cord-005146-o3roa7br 117 6 axons axon NNS cord-005146-o3roa7br 117 7 in in IN cord-005146-o3roa7br 117 8 a a DT cord-005146-o3roa7br 117 9 1:1 1:1 CD cord-005146-o3roa7br 117 10 relationship relationship NN cord-005146-o3roa7br 117 11 . . . cord-005146-o3roa7br 118 1 In in IN cord-005146-o3roa7br 118 2 the the DT cord-005146-o3roa7br 118 3 deep deep JJ cord-005146-o3roa7br 118 4 or or CC cord-005146-o3roa7br 118 5 marginal marginal JJ cord-005146-o3roa7br 118 6 zones zone NNS cord-005146-o3roa7br 118 7 bordering border VBG cord-005146-o3roa7br 118 8 the the DT cord-005146-o3roa7br 118 9 intact intact JJ cord-005146-o3roa7br 118 10 tissue tissue NN cord-005146-o3roa7br 118 11 , , , cord-005146-o3roa7br 118 12 most most JJS cord-005146-o3roa7br 118 13 axons axon NNS cord-005146-o3roa7br 118 14 had have VBD cord-005146-o3roa7br 118 15 thin thin JJ cord-005146-o3roa7br 118 16 myelin myelin NN cord-005146-o3roa7br 118 17 , , , cord-005146-o3roa7br 118 18 which which WDT cord-005146-o3roa7br 118 19 , , , cord-005146-o3roa7br 118 20 unlike unlike IN cord-005146-o3roa7br 118 21 Schwann Schwann NNP cord-005146-o3roa7br 118 22 cell cell NN cord-005146-o3roa7br 118 23 myelin myelin NN cord-005146-o3roa7br 118 24 , , , cord-005146-o3roa7br 118 25 had have VBD cord-005146-o3roa7br 118 26 no no DT cord-005146-o3roa7br 118 27 cytoplasmic cytoplasmic JJ cord-005146-o3roa7br 118 28 layer layer NN cord-005146-o3roa7br 118 29 or or CC cord-005146-o3roa7br 118 30 basal basal NN cord-005146-o3roa7br 118 31 lamina lamina NN cord-005146-o3roa7br 118 32 on on IN cord-005146-o3roa7br 118 33 the the DT cord-005146-o3roa7br 118 34 myelin myelin NN cord-005146-o3roa7br 118 35 sheath sheath NN cord-005146-o3roa7br 118 36 surface surface NN cord-005146-o3roa7br 118 37 , , , cord-005146-o3roa7br 118 38 indicating indicate VBG cord-005146-o3roa7br 118 39 that that IN cord-005146-o3roa7br 118 40 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 118 41 had have VBD cord-005146-o3roa7br 118 42 made make VBN cord-005146-o3roa7br 118 43 the the DT cord-005146-o3roa7br 118 44 myelin myelin NN cord-005146-o3roa7br 118 45 sheaths sheath NNS cord-005146-o3roa7br 118 46 around around IN cord-005146-o3roa7br 118 47 them -PRON- PRP cord-005146-o3roa7br 118 48 . . . cord-005146-o3roa7br 119 1 Blood blood NN cord-005146-o3roa7br 119 2 vessels vessel NNS cord-005146-o3roa7br 119 3 were be VBD cord-005146-o3roa7br 119 4 abundant abundant JJ cord-005146-o3roa7br 119 5 throughout throughout IN cord-005146-o3roa7br 119 6 the the DT cord-005146-o3roa7br 119 7 lesion lesion NN cord-005146-o3roa7br 119 8 but but CC cord-005146-o3roa7br 119 9 macrophages macrophage NNS cord-005146-o3roa7br 119 10 were be VBD cord-005146-o3roa7br 119 11 no no RB cord-005146-o3roa7br 119 12 longer long RBR cord-005146-o3roa7br 119 13 found find VBN cord-005146-o3roa7br 119 14 in in IN cord-005146-o3roa7br 119 15 the the DT cord-005146-o3roa7br 119 16 injured injured JJ cord-005146-o3roa7br 119 17 area area NN cord-005146-o3roa7br 120 1 ( ( -LRB- cord-005146-o3roa7br 120 2 Fig Fig NNP cord-005146-o3roa7br 120 3 . . . cord-005146-o3roa7br 120 4 2F 2F NNP cord-005146-o3roa7br 120 5 ) ) -RRB- cord-005146-o3roa7br 120 6 . . . cord-005146-o3roa7br 121 1 By by IN cord-005146-o3roa7br 121 2 electron electron NN cord-005146-o3roa7br 121 3 microscopy microscopy NN cord-005146-o3roa7br 121 4 it -PRON- PRP cord-005146-o3roa7br 121 5 was be VBD cord-005146-o3roa7br 121 6 determined determine VBN cord-005146-o3roa7br 121 7 that that IN cord-005146-o3roa7br 121 8 almost almost RB cord-005146-o3roa7br 121 9 all all PDT cord-005146-o3roa7br 121 10 the the DT cord-005146-o3roa7br 121 11 axons axon NNS cord-005146-o3roa7br 121 12 near near IN cord-005146-o3roa7br 121 13 the the DT cord-005146-o3roa7br 121 14 pia pia NNP cord-005146-o3roa7br 121 15 ! ! . cord-005146-o3roa7br 122 1 and and CC cord-005146-o3roa7br 122 2 perivascular perivascular NNP cord-005146-o3roa7br 122 3 surfaces surface NNS cord-005146-o3roa7br 122 4 were be VBD cord-005146-o3roa7br 122 5 myelinated myelinate VBN cord-005146-o3roa7br 122 6 by by IN cord-005146-o3roa7br 122 7 Schwann Schwann NNP cord-005146-o3roa7br 122 8 cells cell NNS cord-005146-o3roa7br 122 9 ( ( -LRB- cord-005146-o3roa7br 122 10 Fig Fig NNP cord-005146-o3roa7br 122 11 . . . cord-005146-o3roa7br 122 12 8) 8) NNP cord-005146-o3roa7br 122 13 . . . cord-005146-o3roa7br 123 1 The the DT cord-005146-o3roa7br 123 2 myelin myelin NN cord-005146-o3roa7br 123 3 sheaths sheath NNS cord-005146-o3roa7br 123 4 were be VBD cord-005146-o3roa7br 123 5 0.5 0.5 CD cord-005146-o3roa7br 123 6 - - SYM cord-005146-o3roa7br 123 7 1 1 CD cord-005146-o3roa7br 123 8 # # NN cord-005146-o3roa7br 123 9 , , , cord-005146-o3roa7br 123 10 m m NNP cord-005146-o3roa7br 123 11 thick thick JJ cord-005146-o3roa7br 123 12 and and CC cord-005146-o3roa7br 123 13 had have VBD cord-005146-o3roa7br 123 14 an an DT cord-005146-o3roa7br 123 15 interlamellar interlamellar JJ cord-005146-o3roa7br 123 16 periodicity periodicity NN cord-005146-o3roa7br 123 17 of of IN cord-005146-o3roa7br 123 18 about about IN cord-005146-o3roa7br 123 19 150A. 150a. JJ cord-005146-o3roa7br 123 20 Unmye-231 unmye-231 CD cord-005146-o3roa7br 123 21 linated linated JJ cord-005146-o3roa7br 123 22 axons axon NNS cord-005146-o3roa7br 123 23 were be VBD cord-005146-o3roa7br 123 24 wrapped wrap VBN cord-005146-o3roa7br 123 25 in in IN cord-005146-o3roa7br 123 26 a a DT cord-005146-o3roa7br 123 27 bundle bundle NN cord-005146-o3roa7br 123 28 of of IN cord-005146-o3roa7br 123 29 2 2 CD cord-005146-o3roa7br 123 30 - - SYM cord-005146-o3roa7br 123 31 3 3 CD cord-005146-o3roa7br 123 32 fibres fibre NNS cord-005146-o3roa7br 123 33 by by IN cord-005146-o3roa7br 123 34 a a DT cord-005146-o3roa7br 123 35 common common JJ cord-005146-o3roa7br 123 36 Schwann Schwann NNP cord-005146-o3roa7br 123 37 cell cell NN cord-005146-o3roa7br 123 38 , , , cord-005146-o3roa7br 123 39 as as IN cord-005146-o3roa7br 123 40 in in IN cord-005146-o3roa7br 123 41 unmyelinated unmyelinated JJ cord-005146-o3roa7br 123 42 fibres fibre NNS cord-005146-o3roa7br 123 43 of of IN cord-005146-o3roa7br 123 44 the the DT cord-005146-o3roa7br 123 45 PNS PNS NNP cord-005146-o3roa7br 123 46 . . . cord-005146-o3roa7br 124 1 Schwann Schwann NNP cord-005146-o3roa7br 124 2 cells cell NNS cord-005146-o3roa7br 124 3 were be VBD cord-005146-o3roa7br 124 4 invested invest VBN cord-005146-o3roa7br 124 5 with with IN cord-005146-o3roa7br 124 6 basal basal NN cord-005146-o3roa7br 124 7 laminae laminae NNP cord-005146-o3roa7br 124 8 associated associate VBN cord-005146-o3roa7br 124 9 with with IN cord-005146-o3roa7br 124 10 a a DT cord-005146-o3roa7br 124 11 few few JJ cord-005146-o3roa7br 124 12 collagen collagen NN cord-005146-o3roa7br 124 13 fibrils fibril NNS cord-005146-o3roa7br 124 14 on on IN cord-005146-o3roa7br 124 15 their -PRON- PRP$ cord-005146-o3roa7br 124 16 interstitial interstitial JJ cord-005146-o3roa7br 124 17 surfaces surface NNS cord-005146-o3roa7br 124 18 . . . cord-005146-o3roa7br 125 1 On on IN cord-005146-o3roa7br 125 2 the the DT cord-005146-o3roa7br 125 3 other other JJ cord-005146-o3roa7br 125 4 hand hand NN cord-005146-o3roa7br 125 5 , , , cord-005146-o3roa7br 125 6 in in IN cord-005146-o3roa7br 125 7 the the DT cord-005146-o3roa7br 125 8 deep deep JJ cord-005146-o3roa7br 125 9 and and CC cord-005146-o3roa7br 125 10 marginal marginal JJ cord-005146-o3roa7br 125 11 zones zone NNS cord-005146-o3roa7br 125 12 bordering border VBG cord-005146-o3roa7br 125 13 the the DT cord-005146-o3roa7br 125 14 intact intact JJ cord-005146-o3roa7br 125 15 area area NN cord-005146-o3roa7br 125 16 almost almost RB cord-005146-o3roa7br 125 17 all all PDT cord-005146-o3roa7br 125 18 the the DT cord-005146-o3roa7br 125 19 axons axon NNS cord-005146-o3roa7br 125 20 were be VBD cord-005146-o3roa7br 125 21 myelinated myelinate VBN cord-005146-o3roa7br 125 22 by by IN cord-005146-o3roa7br 125 23 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 125 24 ( ( -LRB- cord-005146-o3roa7br 125 25 Fig Fig NNP cord-005146-o3roa7br 125 26 . . . cord-005146-o3roa7br 125 27 _SP cord-005146-o3roa7br 125 28 9 9 CD cord-005146-o3roa7br 125 29 ) ) -RRB- cord-005146-o3roa7br 125 30 . . . cord-005146-o3roa7br 126 1 Such such JJ cord-005146-o3roa7br 126 2 CNS CNS NNP cord-005146-o3roa7br 126 3 - - HYPH cord-005146-o3roa7br 126 4 type type NN cord-005146-o3roa7br 126 5 myelin myelin NN cord-005146-o3roa7br 126 6 sheaths sheath NNS cord-005146-o3roa7br 126 7 were be VBD cord-005146-o3roa7br 126 8 extremely extremely RB cord-005146-o3roa7br 126 9 thin thin JJ cord-005146-o3roa7br 126 10 ( ( -LRB- cord-005146-o3roa7br 126 11 about about RB cord-005146-o3roa7br 126 12 0.1 0.1 CD cord-005146-o3roa7br 127 1 ~m ~m NNP cord-005146-o3roa7br 127 2 thick thick NNP cord-005146-o3roa7br 127 3 ) ) -RRB- cord-005146-o3roa7br 127 4 , , , cord-005146-o3roa7br 127 5 and and CC cord-005146-o3roa7br 127 6 had have VBD cord-005146-o3roa7br 127 7 an an DT cord-005146-o3roa7br 127 8 interlamellar interlamellar JJ cord-005146-o3roa7br 127 9 periodicity periodicity NN cord-005146-o3roa7br 127 10 of of IN cord-005146-o3roa7br 127 11 about about RB cord-005146-o3roa7br 127 12 130 130 CD cord-005146-o3roa7br 127 13 A. a. NN cord-005146-o3roa7br 128 1 At at IN cord-005146-o3roa7br 128 2 the the DT cord-005146-o3roa7br 128 3 oligodendrocyte oligodendrocyte VBN cord-005146-o3roa7br 128 4 - - : cord-005146-o3roa7br 128 5 and and CC cord-005146-o3roa7br 128 6 Schwann Schwann NNP cord-005146-o3roa7br 128 7 cellmyelination cellmyelination NN cord-005146-o3roa7br 128 8 transition transition NN cord-005146-o3roa7br 128 9 areas area NNS cord-005146-o3roa7br 128 10 , , , cord-005146-o3roa7br 128 11 PNS PNS NNP cord-005146-o3roa7br 128 12 - - HYPH cord-005146-o3roa7br 128 13 and and CC cord-005146-o3roa7br 128 14 CNS CNS NNP cord-005146-o3roa7br 128 15 - - HYPH cord-005146-o3roa7br 128 16 type type NN cord-005146-o3roa7br 128 17 fibres fibre NNS cord-005146-o3roa7br 128 18 intermingled intermingle VBN cord-005146-o3roa7br 128 19 with with IN cord-005146-o3roa7br 128 20 one one NN cord-005146-o3roa7br 128 21 another another DT cord-005146-o3roa7br 128 22 with with IN cord-005146-o3roa7br 128 23 no no DT cord-005146-o3roa7br 128 24 clear clear JJ cord-005146-o3roa7br 128 25 line line NN cord-005146-o3roa7br 128 26 of of IN cord-005146-o3roa7br 128 27 demarcation demarcation NN cord-005146-o3roa7br 128 28 ( ( -LRB- cord-005146-o3roa7br 128 29 Fig Fig NNP cord-005146-o3roa7br 128 30 . . . cord-005146-o3roa7br 128 31 10 10 CD cord-005146-o3roa7br 128 32 ) ) -RRB- cord-005146-o3roa7br 128 33 . . . cord-005146-o3roa7br 129 1 In in IN cord-005146-o3roa7br 129 2 such such JJ cord-005146-o3roa7br 129 3 transitional transitional JJ cord-005146-o3roa7br 129 4 zones zone NNS cord-005146-o3roa7br 129 5 , , , cord-005146-o3roa7br 129 6 the the DT cord-005146-o3roa7br 129 7 oligodendrocyte oligodendrocyte RB cord-005146-o3roa7br 129 8 - - HYPH cord-005146-o3roa7br 129 9 myelinated myelinate VBN cord-005146-o3roa7br 129 10 fibres fibre NNS cord-005146-o3roa7br 129 11 were be VBD cord-005146-o3roa7br 129 12 incompletely incompletely RB cord-005146-o3roa7br 129 13 covered cover VBN cord-005146-o3roa7br 129 14 by by IN cord-005146-o3roa7br 129 15 the the DT cord-005146-o3roa7br 129 16 astrocyte astrocyte NNP cord-005146-o3roa7br 129 17 processes process NNS cord-005146-o3roa7br 129 18 ; ; : cord-005146-o3roa7br 129 19 therefore therefore RB cord-005146-o3roa7br 129 20 CNS cns NN cord-005146-o3roa7br 129 21 - - HYPH cord-005146-o3roa7br 129 22 type type NN cord-005146-o3roa7br 129 23 myelin myelin NN cord-005146-o3roa7br 129 24 sheaths sheath NNS cord-005146-o3roa7br 129 25 and and CC cord-005146-o3roa7br 129 26 oligodendrocyte oligodendrocyte NN cord-005146-o3roa7br 129 27 processes process NNS cord-005146-o3roa7br 129 28 were be VBD cord-005146-o3roa7br 129 29 directly directly RB cord-005146-o3roa7br 129 30 contiguous contiguous JJ cord-005146-o3roa7br 129 31 to to IN cord-005146-o3roa7br 129 32 Schwann Schwann NNP cord-005146-o3roa7br 129 33 cell cell NN cord-005146-o3roa7br 129 34 basal basal NN cord-005146-o3roa7br 129 35 laminae laminae JJ cord-005146-o3roa7br 129 36 or or CC cord-005146-o3roa7br 129 37 collagen collagen NN cord-005146-o3roa7br 129 38 fibrils fibril NNS cord-005146-o3roa7br 129 39 . . . cord-005146-o3roa7br 130 1 Peculiar peculiar JJ cord-005146-o3roa7br 130 2 dark dark JJ cord-005146-o3roa7br 130 3 cells cell NNS cord-005146-o3roa7br 130 4 , , , cord-005146-o3roa7br 130 5 which which WDT cord-005146-o3roa7br 130 6 had have VBD cord-005146-o3roa7br 130 7 previously previously RB cord-005146-o3roa7br 130 8 appeared appear VBN cord-005146-o3roa7br 130 9 as as IN cord-005146-o3roa7br 130 10 spindle spindle NN cord-005146-o3roa7br 130 11 - - HYPH cord-005146-o3roa7br 130 12 shaped shape VBN cord-005146-o3roa7br 130 13 cells cell NNS cord-005146-o3roa7br 130 14 , , , cord-005146-o3roa7br 130 15 proliferated proliferate VBD cord-005146-o3roa7br 130 16 to to TO cord-005146-o3roa7br 130 17 form form VB cord-005146-o3roa7br 130 18 a a DT cord-005146-o3roa7br 130 19 thick thick JJ cord-005146-o3roa7br 130 20 layer layer NN cord-005146-o3roa7br 130 21 on on IN cord-005146-o3roa7br 130 22 the the DT cord-005146-o3roa7br 130 23 pial pial JJ cord-005146-o3roa7br 130 24 surface surface NN cord-005146-o3roa7br 130 25 of of IN cord-005146-o3roa7br 130 26 the the DT cord-005146-o3roa7br 130 27 lesion lesion NN cord-005146-o3roa7br 130 28 . . . cord-005146-o3roa7br 131 1 No no DT cord-005146-o3roa7br 131 2 astrocytic astrocytic JJ cord-005146-o3roa7br 131 3 layer layer NN cord-005146-o3roa7br 131 4 had have VBD cord-005146-o3roa7br 131 5 developed develop VBN cord-005146-o3roa7br 131 6 between between IN cord-005146-o3roa7br 131 7 this this DT cord-005146-o3roa7br 131 8 ' ' `` cord-005146-o3roa7br 131 9 pial pial JJ cord-005146-o3roa7br 131 10 ' ' '' cord-005146-o3roa7br 131 11 cell cell NN cord-005146-o3roa7br 131 12 layer layer NN cord-005146-o3roa7br 131 13 and and CC cord-005146-o3roa7br 131 14 the the DT cord-005146-o3roa7br 131 15 underlying underlying JJ cord-005146-o3roa7br 131 16 neural neural JJ cord-005146-o3roa7br 131 17 tissue tissue NN cord-005146-o3roa7br 131 18 . . . cord-005146-o3roa7br 132 1 Blood blood NN cord-005146-o3roa7br 132 2 vessels vessel NNS cord-005146-o3roa7br 132 3 within within IN cord-005146-o3roa7br 132 4 the the DT cord-005146-o3roa7br 132 5 Schwann Schwann NNP cord-005146-o3roa7br 132 6 cell cell NN cord-005146-o3roa7br 132 7 myelinated myelinated JJ cord-005146-o3roa7br 132 8 areas area NNS cord-005146-o3roa7br 132 9 lacked lack VBD cord-005146-o3roa7br 132 10 an an DT cord-005146-o3roa7br 132 11 astrocytic astrocytic JJ cord-005146-o3roa7br 132 12 covering covering NN cord-005146-o3roa7br 132 13 ; ; : cord-005146-o3roa7br 132 14 these these DT cord-005146-o3roa7br 132 15 vessels vessel NNS cord-005146-o3roa7br 132 16 were be VBD cord-005146-o3roa7br 132 17 thus thus RB cord-005146-o3roa7br 132 18 of of IN cord-005146-o3roa7br 132 19 similar similar JJ cord-005146-o3roa7br 132 20 appearance appearance NN cord-005146-o3roa7br 132 21 to to IN cord-005146-o3roa7br 132 22 those those DT cord-005146-o3roa7br 132 23 found find VBN cord-005146-o3roa7br 132 24 in in IN cord-005146-o3roa7br 132 25 the the DT cord-005146-o3roa7br 132 26 PNS PNS NNP cord-005146-o3roa7br 132 27 . . . cord-005146-o3roa7br 133 1 A a DT cord-005146-o3roa7br 133 2 few few JJ cord-005146-o3roa7br 133 3 macrophages macrophage NNS cord-005146-o3roa7br 133 4 containing contain VBG cord-005146-o3roa7br 133 5 myelin myelin NN cord-005146-o3roa7br 133 6 debris debris NN cord-005146-o3roa7br 133 7 were be VBD cord-005146-o3roa7br 133 8 still still RB cord-005146-o3roa7br 133 9 observed observe VBN cord-005146-o3roa7br 133 10 in in IN cord-005146-o3roa7br 133 11 the the DT cord-005146-o3roa7br 133 12 affected affected JJ cord-005146-o3roa7br 133 13 area area NN cord-005146-o3roa7br 133 14 . . . cord-005146-o3roa7br 134 1 In in IN cord-005146-o3roa7br 134 2 longitudinal longitudinal JJ cord-005146-o3roa7br 134 3 sections section NNS cord-005146-o3roa7br 134 4 , , , cord-005146-o3roa7br 134 5 internodes internode NNS cord-005146-o3roa7br 134 6 of of IN cord-005146-o3roa7br 134 7 CNS CNS NNP cord-005146-o3roa7br 134 8 - - HYPH cord-005146-o3roa7br 134 9 type type NN cord-005146-o3roa7br 134 10 remyelinated remyelinate VBN cord-005146-o3roa7br 134 11 axons axon NNS cord-005146-o3roa7br 134 12 were be VBD cord-005146-o3roa7br 134 13 so so RB cord-005146-o3roa7br 134 14 short short JJ cord-005146-o3roa7br 134 15 that that IN cord-005146-o3roa7br 134 16 the the DT cord-005146-o3roa7br 134 17 entire entire JJ cord-005146-o3roa7br 134 18 internode internode NNP cord-005146-o3roa7br 134 19 could could MD cord-005146-o3roa7br 134 20 be be VB cord-005146-o3roa7br 134 21 followed follow VBN cord-005146-o3roa7br 134 22 in in IN cord-005146-o3roa7br 134 23 one one CD cord-005146-o3roa7br 134 24 section section NN cord-005146-o3roa7br 134 25 , , , cord-005146-o3roa7br 134 26 whereas whereas IN cord-005146-o3roa7br 134 27 those those DT cord-005146-o3roa7br 134 28 of of IN cord-005146-o3roa7br 134 29 PNS PNS NNP cord-005146-o3roa7br 134 30 - - HYPH cord-005146-o3roa7br 134 31 type type NN cord-005146-o3roa7br 134 32 internodes internode NNS cord-005146-o3roa7br 134 33 were be VBD cord-005146-o3roa7br 134 34 longer long JJR cord-005146-o3roa7br 134 35 and and CC cord-005146-o3roa7br 134 36 only only JJ cord-005146-o3roa7br 134 37 part part NN cord-005146-o3roa7br 134 38 of of IN cord-005146-o3roa7br 134 39 an an DT cord-005146-o3roa7br 134 40 internode internode NN cord-005146-o3roa7br 134 41 was be VBD cord-005146-o3roa7br 134 42 traceable traceable JJ cord-005146-o3roa7br 134 43 in in IN cord-005146-o3roa7br 134 44 one one CD cord-005146-o3roa7br 134 45 section section NN cord-005146-o3roa7br 134 46 . . . cord-005146-o3roa7br 135 1 Nodes node NNS cord-005146-o3roa7br 135 2 of of IN cord-005146-o3roa7br 135 3 Ranvier Ranvier NNP cord-005146-o3roa7br 135 4 of of IN cord-005146-o3roa7br 135 5 the the DT cord-005146-o3roa7br 135 6 PNS PNS NNP cord-005146-o3roa7br 135 7 - - HYPH cord-005146-o3roa7br 135 8 type type NN cord-005146-o3roa7br 135 9 had have VBD cord-005146-o3roa7br 135 10 a a DT cord-005146-o3roa7br 135 11 normal normal JJ cord-005146-o3roa7br 135 12 structure structure NN cord-005146-o3roa7br 135 13 , , , cord-005146-o3roa7br 135 14 while while IN cord-005146-o3roa7br 135 15 those those DT cord-005146-o3roa7br 135 16 of of IN cord-005146-o3roa7br 135 17 a a DT cord-005146-o3roa7br 135 18 CNS CNS NNP cord-005146-o3roa7br 135 19 - - HYPH cord-005146-o3roa7br 135 20 type type NN cord-005146-o3roa7br 135 21 occasionally occasionally RB cord-005146-o3roa7br 135 22 exhibited exhibit VBD cord-005146-o3roa7br 135 23 abnormally abnormally RB cord-005146-o3roa7br 135 24 wide wide JJ cord-005146-o3roa7br 135 25 gaps gap NNS cord-005146-o3roa7br 135 26 . . . cord-005146-o3roa7br 136 1 Oligodendrocytes Oligodendrocytes NNP cord-005146-o3roa7br 136 2 sometimes sometimes RB cord-005146-o3roa7br 136 3 formed form VBD cord-005146-o3roa7br 136 4 a a DT cord-005146-o3roa7br 136 5 thin thin JJ cord-005146-o3roa7br 136 6 myelin myelin NN cord-005146-o3roa7br 136 7 sheath sheath NN cord-005146-o3roa7br 136 8 on on IN cord-005146-o3roa7br 136 9 their -PRON- PRP$ cord-005146-o3roa7br 136 10 own own JJ cord-005146-o3roa7br 136 11 cell cell NN cord-005146-o3roa7br 136 12 body body NN cord-005146-o3roa7br 136 13 . . . cord-005146-o3roa7br 137 1 Newly newly RB cord-005146-o3roa7br 137 2 formed form VBN cord-005146-o3roa7br 137 3 PNS PNS NNP cord-005146-o3roa7br 137 4 - - : cord-005146-o3roa7br 137 5 or or CC cord-005146-o3roa7br 137 6 CNS CNS NNP cord-005146-o3roa7br 137 7 - - HYPH cord-005146-o3roa7br 137 8 type type NN cord-005146-o3roa7br 137 9 myelin myelin NN cord-005146-o3roa7br 137 10 sheaths sheath NNS cord-005146-o3roa7br 137 11 were be VBD cord-005146-o3roa7br 137 12 apposed appose VBN cord-005146-o3roa7br 137 13 to to IN cord-005146-o3roa7br 137 14 the the DT cord-005146-o3roa7br 137 15 adjacent adjacent JJ cord-005146-o3roa7br 137 16 intact intact JJ cord-005146-o3roa7br 137 17 CNS cns JJ cord-005146-o3roa7br 137 18 myelin myelin NN cord-005146-o3roa7br 137 19 sheaths sheath NNS cord-005146-o3roa7br 137 20 at at IN cord-005146-o3roa7br 137 21 nodes node NNS cord-005146-o3roa7br 137 22 of of IN cord-005146-o3roa7br 137 23 Ranvier Ranvier NNP cord-005146-o3roa7br 137 24 . . . cord-005146-o3roa7br 138 1 Sometimes sometimes RB cord-005146-o3roa7br 138 2 a a DT cord-005146-o3roa7br 138 3 single single JJ cord-005146-o3roa7br 138 4 axon axon NN cord-005146-o3roa7br 138 5 was be VBD cord-005146-o3roa7br 138 6 remyelinated remyelinate VBN cord-005146-o3roa7br 138 7 by by IN cord-005146-o3roa7br 138 8 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 138 9 and and CC cord-005146-o3roa7br 138 10 by by IN cord-005146-o3roa7br 138 11 Schwann Schwann NNP cord-005146-o3roa7br 138 12 cells cell NNS cord-005146-o3roa7br 138 13 forming form VBG cord-005146-o3roa7br 138 14 alternate alternate JJ cord-005146-o3roa7br 138 15 PNS PNS NNP cord-005146-o3roa7br 138 16 - - : cord-005146-o3roa7br 138 17 and and CC cord-005146-o3roa7br 138 18 CNS CNS NNP cord-005146-o3roa7br 138 19 - - HYPH cord-005146-o3roa7br 138 20 type type NN cord-005146-o3roa7br 138 21 myelin myelin NN cord-005146-o3roa7br 138 22 sheaths sheath NNS cord-005146-o3roa7br 138 23 ( ( -LRB- cord-005146-o3roa7br 138 24 Fig fig NN cord-005146-o3roa7br 138 25 . . . cord-005146-o3roa7br 138 26 11 11 CD cord-005146-o3roa7br 138 27 ) ) -RRB- cord-005146-o3roa7br 138 28 . . . cord-005146-o3roa7br 139 1 Usually usually RB cord-005146-o3roa7br 139 2 only only RB cord-005146-o3roa7br 139 3 a a DT cord-005146-o3roa7br 139 4 few few JJ cord-005146-o3roa7br 139 5 astrocyte astrocyte NN cord-005146-o3roa7br 139 6 processes process NNS cord-005146-o3roa7br 139 7 covered cover VBD cord-005146-o3roa7br 139 8 these these DT cord-005146-o3roa7br 139 9 newly newly RB cord-005146-o3roa7br 139 10 formed form VBN cord-005146-o3roa7br 139 11 nodes node NNS cord-005146-o3roa7br 139 12 of of IN cord-005146-o3roa7br 139 13 Ranvier Ranvier NNP cord-005146-o3roa7br 139 14 . . . cord-005146-o3roa7br 140 1 Unlike unlike IN cord-005146-o3roa7br 140 2 the the DT cord-005146-o3roa7br 140 3 normal normal JJ cord-005146-o3roa7br 140 4 PNS PNS NNP cord-005146-o3roa7br 140 5 - - HYPH cord-005146-o3roa7br 140 6 CNS CNS NNP cord-005146-o3roa7br 140 7 transition transition NN cord-005146-o3roa7br 140 8 in in IN cord-005146-o3roa7br 140 9 the the DT cord-005146-o3roa7br 140 10 nerve nerve NN cord-005146-o3roa7br 140 11 root root NN cord-005146-o3roa7br 140 12 , , , cord-005146-o3roa7br 140 13 lateral lateral JJ cord-005146-o3roa7br 140 14 loops loop NNS cord-005146-o3roa7br 140 15 of of IN cord-005146-o3roa7br 140 16 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 140 17 were be VBD cord-005146-o3roa7br 140 18 directly directly RB cord-005146-o3roa7br 140 19 contiguous contiguous JJ cord-005146-o3roa7br 140 20 with with IN cord-005146-o3roa7br 140 21 Schwann Schwann NNP cord-005146-o3roa7br 140 22 cell cell NN cord-005146-o3roa7br 140 23 processes process NNS cord-005146-o3roa7br 140 24 at at IN cord-005146-o3roa7br 140 25 the the DT cord-005146-o3roa7br 140 26 node node NN cord-005146-o3roa7br 140 27 ( ( -LRB- cord-005146-o3roa7br 140 28 Fig Fig NNP cord-005146-o3roa7br 140 29 . . NNP cord-005146-o3roa7br 140 30 11 11 CD cord-005146-o3roa7br 140 31 , , , cord-005146-o3roa7br 140 32 inset inset NN cord-005146-o3roa7br 140 33 . . . cord-005146-o3roa7br 140 34 ) ) -RRB- cord-005146-o3roa7br 140 35 . . . cord-005146-o3roa7br 140 36 _SP cord-005146-o3roa7br 141 1 The the DT cord-005146-o3roa7br 141 2 present present JJ cord-005146-o3roa7br 141 3 study study NN cord-005146-o3roa7br 141 4 has have VBZ cord-005146-o3roa7br 141 5 documented document VBN cord-005146-o3roa7br 141 6 the the DT cord-005146-o3roa7br 141 7 morphological morphological JJ cord-005146-o3roa7br 141 8 changes change NNS cord-005146-o3roa7br 141 9 in in IN cord-005146-o3roa7br 141 10 the the DT cord-005146-o3roa7br 141 11 spinal spinal JJ cord-005146-o3roa7br 141 12 cord cord NN cord-005146-o3roa7br 141 13 injured injure VBN cord-005146-o3roa7br 141 14 by by IN cord-005146-o3roa7br 141 15 heat heat NN cord-005146-o3roa7br 141 16 treatment treatment NN cord-005146-o3roa7br 141 17 , , , cord-005146-o3roa7br 141 18 as as IN cord-005146-o3roa7br 141 19 observed observe VBN cord-005146-o3roa7br 141 20 by by IN cord-005146-o3roa7br 141 21 light light NN cord-005146-o3roa7br 141 22 and and CC cord-005146-o3roa7br 141 23 electron electron NN cord-005146-o3roa7br 141 24 microscopy microscopy NN cord-005146-o3roa7br 141 25 . . . cord-005146-o3roa7br 142 1 Using use VBG cord-005146-o3roa7br 142 2 hot hot JJ cord-005146-o3roa7br 142 3 water water NN cord-005146-o3roa7br 142 4 circulating circulate VBG cord-005146-o3roa7br 142 5 in in IN cord-005146-o3roa7br 142 6 a a DT cord-005146-o3roa7br 142 7 tube tube NN cord-005146-o3roa7br 142 8 , , , cord-005146-o3roa7br 142 9 we -PRON- PRP cord-005146-o3roa7br 142 10 made make VBD cord-005146-o3roa7br 142 11 a a DT cord-005146-o3roa7br 142 12 small small JJ cord-005146-o3roa7br 142 13 ( ( -LRB- cord-005146-o3roa7br 142 14 less less JJR cord-005146-o3roa7br 142 15 than than IN cord-005146-o3roa7br 142 16 I -PRON- PRP cord-005146-o3roa7br 142 17 mm~ mm~ VBZ cord-005146-o3roa7br 142 18 ) ) -RRB- cord-005146-o3roa7br 142 19 , , , cord-005146-o3roa7br 142 20 well well RB cord-005146-o3roa7br 142 21 - - HYPH cord-005146-o3roa7br 142 22 confined confine VBN cord-005146-o3roa7br 142 23 lesion lesion NN cord-005146-o3roa7br 142 24 in in IN cord-005146-o3roa7br 142 25 the the DT cord-005146-o3roa7br 142 26 dorsal dorsal JJ cord-005146-o3roa7br 142 27 funiculus funiculu NNS cord-005146-o3roa7br 142 28 of of IN cord-005146-o3roa7br 142 29 the the DT cord-005146-o3roa7br 142 30 rat rat NN cord-005146-o3roa7br 142 31 spinal spinal JJ cord-005146-o3roa7br 142 32 cord cord NN cord-005146-o3roa7br 142 33 . . . cord-005146-o3roa7br 143 1 According accord VBG cord-005146-o3roa7br 143 2 to to IN cord-005146-o3roa7br 143 3 previous previous JJ cord-005146-o3roa7br 143 4 reports report NNS cord-005146-o3roa7br 143 5 ( ( -LRB- cord-005146-o3roa7br 143 6 Britt Britt NNP cord-005146-o3roa7br 143 7 et et NNP cord-005146-o3roa7br 143 8 al al NNP cord-005146-o3roa7br 143 9 . . NNP cord-005146-o3roa7br 143 10 , , , cord-005146-o3roa7br 143 11 1983 1983 CD cord-005146-o3roa7br 143 12 ; ; : cord-005146-o3roa7br 143 13 Lyons Lyons NNP cord-005146-o3roa7br 143 14 et et NNP cord-005146-o3roa7br 143 15 al al NNP cord-005146-o3roa7br 143 16 . . NNP cord-005146-o3roa7br 143 17 , , , cord-005146-o3roa7br 143 18 1984 1984 CD cord-005146-o3roa7br 143 19 ) ) -RRB- cord-005146-o3roa7br 143 20 , , , cord-005146-o3roa7br 143 21 the the DT cord-005146-o3roa7br 143 22 temperature temperature NN cord-005146-o3roa7br 143 23 threshold threshold NN cord-005146-o3roa7br 143 24 for for IN cord-005146-o3roa7br 143 25 cell cell NN cord-005146-o3roa7br 143 26 damage damage NN cord-005146-o3roa7br 143 27 in in IN cord-005146-o3roa7br 143 28 the the DT cord-005146-o3roa7br 143 29 CNS CNS NNP cord-005146-o3roa7br 143 30 is be VBZ cord-005146-o3roa7br 143 31 42 42 CD cord-005146-o3roa7br 143 32 - - SYM cord-005146-o3roa7br 143 33 43~ 43~ CD cord-005146-o3roa7br 143 34 C c NN cord-005146-o3roa7br 143 35 for for IN cord-005146-o3roa7br 143 36 a a DT cord-005146-o3roa7br 143 37 duration duration NN cord-005146-o3roa7br 143 38 of of IN cord-005146-o3roa7br 143 39 50 50 CD cord-005146-o3roa7br 143 40 - - SYM cord-005146-o3roa7br 143 41 60 60 CD cord-005146-o3roa7br 143 42 min min NN cord-005146-o3roa7br 143 43 . . . cord-005146-o3roa7br 144 1 In in IN cord-005146-o3roa7br 144 2 the the DT cord-005146-o3roa7br 144 3 present present JJ cord-005146-o3roa7br 144 4 study study NN cord-005146-o3roa7br 144 5 the the DT cord-005146-o3roa7br 144 6 tube tube NN cord-005146-o3roa7br 144 7 was be VBD cord-005146-o3roa7br 144 8 kept keep VBN cord-005146-o3roa7br 144 9 at at IN cord-005146-o3roa7br 144 10 48 48 CD cord-005146-o3roa7br 144 11 - - SYM cord-005146-o3roa7br 144 12 50 50 CD cord-005146-o3roa7br 145 1 ~ ~ NFP cord-005146-o3roa7br 145 2 C c NN cord-005146-o3roa7br 145 3 on on IN cord-005146-o3roa7br 145 4 the the DT cord-005146-o3roa7br 145 5 surface surface NN cord-005146-o3roa7br 145 6 of of IN cord-005146-o3roa7br 145 7 the the DT cord-005146-o3roa7br 145 8 dura dura NN cord-005146-o3roa7br 145 9 : : : cord-005146-o3roa7br 145 10 this this DT cord-005146-o3roa7br 145 11 elevated elevate VBD cord-005146-o3roa7br 145 12 the the DT cord-005146-o3roa7br 145 13 temperature temperature NN cord-005146-o3roa7br 145 14 in in IN cord-005146-o3roa7br 145 15 the the DT cord-005146-o3roa7br 145 16 tissue tissue NN cord-005146-o3roa7br 145 17 high high JJ cord-005146-o3roa7br 145 18 enough enough RB cord-005146-o3roa7br 145 19 to to TO cord-005146-o3roa7br 145 20 cause cause VB cord-005146-o3roa7br 145 21 damage damage NN cord-005146-o3roa7br 145 22 to to IN cord-005146-o3roa7br 145 23 glial glial JJ cord-005146-o3roa7br 145 24 cells cell NNS cord-005146-o3roa7br 145 25 but but CC cord-005146-o3roa7br 145 26 not not RB cord-005146-o3roa7br 145 27 axons axon NNS cord-005146-o3roa7br 145 28 . . . cord-005146-o3roa7br 146 1 The the DT cord-005146-o3roa7br 146 2 spinal spinal JJ cord-005146-o3roa7br 146 3 cord cord NN cord-005146-o3roa7br 146 4 is be VBZ cord-005146-o3roa7br 146 5 susceptible susceptible JJ cord-005146-o3roa7br 146 6 to to IN cord-005146-o3roa7br 146 7 compression compression NN cord-005146-o3roa7br 146 8 : : : cord-005146-o3roa7br 146 9 demyelination demyelination NN cord-005146-o3roa7br 146 10 as as RB cord-005146-o3roa7br 146 11 well well RB cord-005146-o3roa7br 146 12 as as IN cord-005146-o3roa7br 146 13 axonal axonal JJ cord-005146-o3roa7br 146 14 degeneration degeneration NN cord-005146-o3roa7br 146 15 can can MD cord-005146-o3roa7br 146 16 occur occur VB cord-005146-o3roa7br 146 17 following follow VBG cord-005146-o3roa7br 146 18 mild mild JJ cord-005146-o3roa7br 146 19 compression compression NN cord-005146-o3roa7br 146 20 ( ( -LRB- cord-005146-o3roa7br 146 21 Gledhill Gledhill NNP cord-005146-o3roa7br 146 22 et et NNP cord-005146-o3roa7br 146 23 al al NNP cord-005146-o3roa7br 146 24 . . NNP cord-005146-o3roa7br 146 25 , , , cord-005146-o3roa7br 146 26 1973 1973 CD cord-005146-o3roa7br 146 27 ; ; : cord-005146-o3roa7br 146 28 Harrison Harrison NNP cord-005146-o3roa7br 146 29 et et NNP cord-005146-o3roa7br 146 30 al al NNP cord-005146-o3roa7br 146 31 . . NNP cord-005146-o3roa7br 146 32 , , , cord-005146-o3roa7br 146 33 1975 1975 CD cord-005146-o3roa7br 146 34 ) ) -RRB- cord-005146-o3roa7br 146 35 . . . cord-005146-o3roa7br 147 1 In in IN cord-005146-o3roa7br 147 2 the the DT cord-005146-o3roa7br 147 3 present present JJ cord-005146-o3roa7br 147 4 study study NN cord-005146-o3roa7br 147 5 , , , cord-005146-o3roa7br 147 6 demyelination demyelination NN cord-005146-o3roa7br 147 7 was be VBD cord-005146-o3roa7br 147 8 not not RB cord-005146-o3roa7br 147 9 found find VBN cord-005146-o3roa7br 147 10 in in IN cord-005146-o3roa7br 147 11 the the DT cord-005146-o3roa7br 147 12 dorsal dorsal JJ cord-005146-o3roa7br 147 13 funiculus funiculu NNS cord-005146-o3roa7br 147 14 of of IN cord-005146-o3roa7br 147 15 any any DT cord-005146-o3roa7br 147 16 control control NN cord-005146-o3roa7br 147 17 animals animal NNS cord-005146-o3roa7br 147 18 , , , cord-005146-o3roa7br 147 19 including include VBG cord-005146-o3roa7br 147 20 those those DT cord-005146-o3roa7br 147 21 exposed expose VBN cord-005146-o3roa7br 147 22 to to IN cord-005146-o3roa7br 147 23 a a DT cord-005146-o3roa7br 147 24 temperature temperature NN cord-005146-o3roa7br 148 1 o o UH cord-005146-o3roa7br 148 2 f f NNP cord-005146-o3roa7br 148 3 40 40 CD cord-005146-o3roa7br 148 4 - - SYM cord-005146-o3roa7br 148 5 45 45 CD cord-005146-o3roa7br 149 1 ~ ~ NFP cord-005146-o3roa7br 149 2 C. C. NNP cord-005146-o3roa7br 150 1 Even even RB cord-005146-o3roa7br 150 2 in in IN cord-005146-o3roa7br 150 3 cases case NNS cord-005146-o3roa7br 150 4 in in IN cord-005146-o3roa7br 150 5 which which WDT cord-005146-o3roa7br 150 6 spinal spinal JJ cord-005146-o3roa7br 150 7 cords cord NNS cord-005146-o3roa7br 150 8 were be VBD cord-005146-o3roa7br 150 9 accidentally accidentally RB cord-005146-o3roa7br 150 10 deformed deform VBN cord-005146-o3roa7br 150 11 by by IN cord-005146-o3roa7br 150 12 compression compression NN cord-005146-o3roa7br 150 13 , , , cord-005146-o3roa7br 150 14 no no DT cord-005146-o3roa7br 150 15 demyelination demyelination NN cord-005146-o3roa7br 150 16 nor nor CC cord-005146-o3roa7br 150 17 axonal axonal JJ cord-005146-o3roa7br 150 18 degeneration degeneration NN cord-005146-o3roa7br 150 19 was be VBD cord-005146-o3roa7br 150 20 found find VBN cord-005146-o3roa7br 150 21 in in IN cord-005146-o3roa7br 150 22 the the DT cord-005146-o3roa7br 150 23 spinal spinal JJ cord-005146-o3roa7br 150 24 cord cord NN cord-005146-o3roa7br 150 25 indicating indicate VBG cord-005146-o3roa7br 150 26 that that IN cord-005146-o3roa7br 150 27 demyelination demyelination NN cord-005146-o3roa7br 150 28 was be VBD cord-005146-o3roa7br 150 29 not not RB cord-005146-o3roa7br 150 30 the the DT cord-005146-o3roa7br 150 31 result result NN cord-005146-o3roa7br 150 32 of of IN cord-005146-o3roa7br 150 33 compression compression NN cord-005146-o3roa7br 150 34 but but CC cord-005146-o3roa7br 150 35 the the DT cord-005146-o3roa7br 150 36 direct direct JJ cord-005146-o3roa7br 150 37 result result NN cord-005146-o3roa7br 150 38 of of IN cord-005146-o3roa7br 150 39 heating heating NN cord-005146-o3roa7br 150 40 . . . cord-005146-o3roa7br 151 1 In in IN cord-005146-o3roa7br 151 2 the the DT cord-005146-o3roa7br 151 3 present present JJ cord-005146-o3roa7br 151 4 study study NN cord-005146-o3roa7br 151 5 the the DT cord-005146-o3roa7br 151 6 widespread widespread JJ cord-005146-o3roa7br 151 7 demyelination demyelination NN cord-005146-o3roa7br 151 8 occurred occur VBD cord-005146-o3roa7br 151 9 without without IN cord-005146-o3roa7br 151 10 any any DT cord-005146-o3roa7br 151 11 noticeable noticeable JJ cord-005146-o3roa7br 151 12 damage damage NN cord-005146-o3roa7br 151 13 to to IN cord-005146-o3roa7br 151 14 the the DT cord-005146-o3roa7br 151 15 axons axon NNS cord-005146-o3roa7br 151 16 . . . cord-005146-o3roa7br 152 1 Most Most JJS cord-005146-o3roa7br 152 2 myelin myelin NN cord-005146-o3roa7br 152 3 sheaths sheath NNS cord-005146-o3roa7br 152 4 were be VBD cord-005146-o3roa7br 152 5 degraded degrade VBN cord-005146-o3roa7br 152 6 by by IN cord-005146-o3roa7br 152 7 splitting splitting NN cord-005146-o3roa7br 152 8 of of IN cord-005146-o3roa7br 152 9 the the DT cord-005146-o3roa7br 152 10 myelin myelin NN cord-005146-o3roa7br 152 11 lamellae lamella NNS cord-005146-o3roa7br 152 12 as as IN cord-005146-o3roa7br 152 13 was be VBD cord-005146-o3roa7br 152 14 reported report VBN cord-005146-o3roa7br 152 15 by by IN cord-005146-o3roa7br 152 16 Hirano Hirano NNP cord-005146-o3roa7br 152 17 ( ( -LRB- cord-005146-o3roa7br 152 18 1972 1972 CD cord-005146-o3roa7br 152 19 ) ) -RRB- cord-005146-o3roa7br 152 20 , , , cord-005146-o3roa7br 152 21 _SP cord-005146-o3roa7br 152 22 Fig Fig NNP cord-005146-o3roa7br 152 23 . . NNP cord-005146-o3roa7br 152 24 7 7 CD cord-005146-o3roa7br 152 25 . . . cord-005146-o3roa7br 153 1 Two two CD cord-005146-o3roa7br 153 2 weeks week NNS cord-005146-o3roa7br 153 3 after after IN cord-005146-o3roa7br 153 4 treatment treatment NN cord-005146-o3roa7br 153 5 . . . cord-005146-o3roa7br 154 1 This this DT cord-005146-o3roa7br 154 2 electron electron NN cord-005146-o3roa7br 154 3 micrograph micrograph NN cord-005146-o3roa7br 154 4 was be VBD cord-005146-o3roa7br 154 5 taken take VBN cord-005146-o3roa7br 154 6 from from IN cord-005146-o3roa7br 154 7 the the DT cord-005146-o3roa7br 154 8 deep deep JJ cord-005146-o3roa7br 154 9 zone zone NN cord-005146-o3roa7br 154 10 bordering border VBG cord-005146-o3roa7br 154 11 the the DT cord-005146-o3roa7br 154 12 intact intact JJ cord-005146-o3roa7br 154 13 area area NN cord-005146-o3roa7br 154 14 of of IN cord-005146-o3roa7br 154 15 the the DT cord-005146-o3roa7br 154 16 affected affected JJ cord-005146-o3roa7br 154 17 dorsal dorsal JJ cord-005146-o3roa7br 154 18 funiculus funiculu NNS cord-005146-o3roa7br 154 19 . . . cord-005146-o3roa7br 155 1 Almost almost RB cord-005146-o3roa7br 155 2 all all PDT cord-005146-o3roa7br 155 3 the the DT cord-005146-o3roa7br 155 4 axons axon NNS cord-005146-o3roa7br 155 5 ( ( -LRB- cord-005146-o3roa7br 155 6 Ax Ax NNP cord-005146-o3roa7br 155 7 ) ) -RRB- cord-005146-o3roa7br 155 8 in in IN cord-005146-o3roa7br 155 9 the the DT cord-005146-o3roa7br 155 10 area area NN cord-005146-o3roa7br 155 11 are be VBP cord-005146-o3roa7br 155 12 thinly thinly RB cord-005146-o3roa7br 155 13 myelinated myelinate VBN cord-005146-o3roa7br 155 14 by by IN cord-005146-o3roa7br 155 15 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 155 16 ( ( -LRB- cord-005146-o3roa7br 155 17 O1 O1 NNP cord-005146-o3roa7br 155 18 ) ) -RRB- cord-005146-o3roa7br 155 19 , , , cord-005146-o3roa7br 155 20 while while IN cord-005146-o3roa7br 155 21 a a DT cord-005146-o3roa7br 155 22 few few JJ cord-005146-o3roa7br 155 23 axons axon NNS cord-005146-o3roa7br 155 24 remain remain VBP cord-005146-o3roa7br 155 25 unmyelinated unmyelinated JJ cord-005146-o3roa7br 155 26 . . . cord-005146-o3roa7br 156 1 Proliferation proliferation NN cord-005146-o3roa7br 156 2 of of IN cord-005146-o3roa7br 156 3 astrocyte astrocyte NN cord-005146-o3roa7br 156 4 processes process NNS cord-005146-o3roa7br 156 5 ( ( -LRB- cord-005146-o3roa7br 156 6 As as IN cord-005146-o3roa7br 156 7 ) ) -RRB- cord-005146-o3roa7br 156 8 has have VBZ cord-005146-o3roa7br 156 9 occurred occur VBN cord-005146-o3roa7br 156 10 in in IN cord-005146-o3roa7br 156 11 the the DT cord-005146-o3roa7br 156 12 spaces space NNS cord-005146-o3roa7br 156 13 between between IN cord-005146-o3roa7br 156 14 these these DT cord-005146-o3roa7br 156 15 axons axon NNS cord-005146-o3roa7br 156 16 , , , cord-005146-o3roa7br 156 17 x x CD cord-005146-o3roa7br 156 18 7200 7200 CD cord-005146-o3roa7br 156 19 . . . cord-005146-o3roa7br 157 1 while while IN cord-005146-o3roa7br 157 2 others other NNS cord-005146-o3roa7br 157 3 initially initially RB cord-005146-o3roa7br 157 4 only only RB cord-005146-o3roa7br 157 5 lost lose VBD cord-005146-o3roa7br 157 6 their -PRON- PRP$ cord-005146-o3roa7br 157 7 electron electron NN cord-005146-o3roa7br 157 8 opacity opacity NN cord-005146-o3roa7br 157 9 while while IN cord-005146-o3roa7br 157 10 retaining retain VBG cord-005146-o3roa7br 157 11 their -PRON- PRP$ cord-005146-o3roa7br 157 12 original original JJ cord-005146-o3roa7br 157 13 compact compact JJ cord-005146-o3roa7br 157 14 lamellae lamella NNS cord-005146-o3roa7br 157 15 . . . cord-005146-o3roa7br 158 1 Myelin myelin NN cord-005146-o3roa7br 158 2 sheath sheath NN cord-005146-o3roa7br 158 3 changes change NNS cord-005146-o3roa7br 158 4 of of IN cord-005146-o3roa7br 158 5 the the DT cord-005146-o3roa7br 158 6 latter latter JJ cord-005146-o3roa7br 158 7 type type NN cord-005146-o3roa7br 158 8 have have VBP cord-005146-o3roa7br 158 9 also also RB cord-005146-o3roa7br 158 10 been be VBN cord-005146-o3roa7br 158 11 found find VBN cord-005146-o3roa7br 158 12 in in IN cord-005146-o3roa7br 158 13 the the DT cord-005146-o3roa7br 158 14 cryo cryo NN cord-005146-o3roa7br 158 15 - - HYPH cord-005146-o3roa7br 158 16 treated treat VBN cord-005146-o3roa7br 158 17 spinal spinal JJ cord-005146-o3roa7br 158 18 cord cord NN cord-005146-o3roa7br 158 19 ( ( -LRB- cord-005146-o3roa7br 158 20 unpublished unpublished JJ cord-005146-o3roa7br 158 21 observations observation NNS cord-005146-o3roa7br 158 22 ) ) -RRB- cord-005146-o3roa7br 158 23 . . . cord-005146-o3roa7br 159 1 Vulnerability vulnerability NN cord-005146-o3roa7br 159 2 of of IN cord-005146-o3roa7br 159 3 the the DT cord-005146-o3roa7br 159 4 myelin myelin NN cord-005146-o3roa7br 159 5 sheath sheath NN cord-005146-o3roa7br 159 6 to to IN cord-005146-o3roa7br 159 7 heating heating NN cord-005146-o3roa7br 159 8 can can MD cord-005146-o3roa7br 159 9 probably probably RB cord-005146-o3roa7br 159 10 be be VB cord-005146-o3roa7br 159 11 related relate VBN cord-005146-o3roa7br 159 12 to to IN cord-005146-o3roa7br 159 13 the the DT cord-005146-o3roa7br 159 14 high high JJ cord-005146-o3roa7br 159 15 lipid lipid NN cord-005146-o3roa7br 159 16 content content NN cord-005146-o3roa7br 159 17 and and CC cord-005146-o3roa7br 159 18 structural structural JJ cord-005146-o3roa7br 159 19 characteristics characteristic NNS cord-005146-o3roa7br 159 20 of of IN cord-005146-o3roa7br 159 21 the the DT cord-005146-o3roa7br 159 22 membrane membrane NN cord-005146-o3roa7br 159 23 . . . cord-005146-o3roa7br 160 1 Raison Raison NNP cord-005146-o3roa7br 160 2 et et NNP cord-005146-o3roa7br 160 3 al al NNP cord-005146-o3roa7br 160 4 . . . cord-005146-o3roa7br 161 1 ( ( -LRB- cord-005146-o3roa7br 161 2 1971 1971 CD cord-005146-o3roa7br 161 3 ) ) -RRB- cord-005146-o3roa7br 161 4 utilizing utilize VBG cord-005146-o3roa7br 161 5 electron electron NN cord-005146-o3roa7br 161 6 spin spin NN cord-005146-o3roa7br 161 7 resonance resonance NN cord-005146-o3roa7br 161 8 demonstrated demonstrate VBD cord-005146-o3roa7br 161 9 that that IN cord-005146-o3roa7br 161 10 heating heating NN cord-005146-o3roa7br 161 11 gives give VBZ cord-005146-o3roa7br 161 12 rise rise NN cord-005146-o3roa7br 161 13 to to IN cord-005146-o3roa7br 161 14 changes change NNS cord-005146-o3roa7br 161 15 in in IN cord-005146-o3roa7br 161 16 the the DT cord-005146-o3roa7br 161 17 lipid lipid NN cord-005146-o3roa7br 161 18 components component NNS cord-005146-o3roa7br 161 19 of of IN cord-005146-o3roa7br 161 20 the the DT cord-005146-o3roa7br 161 21 plasma plasma NN cord-005146-o3roa7br 161 22 membrane membrane NN cord-005146-o3roa7br 161 23 . . . cord-005146-o3roa7br 162 1 Similarly similarly RB cord-005146-o3roa7br 162 2 , , , cord-005146-o3roa7br 162 3 the the DT cord-005146-o3roa7br 162 4 organizations organization NNS cord-005146-o3roa7br 162 5 of of IN cord-005146-o3roa7br 162 6 membraneincorporated membraneincorporated JJ cord-005146-o3roa7br 162 7 proteins protein NNS cord-005146-o3roa7br 162 8 are be VBP cord-005146-o3roa7br 162 9 considered consider VBN cord-005146-o3roa7br 162 10 to to TO cord-005146-o3roa7br 162 11 be be VB cord-005146-o3roa7br 162 12 easily easily RB cord-005146-o3roa7br 162 13 altered alter VBN cord-005146-o3roa7br 162 14 by by IN cord-005146-o3roa7br 162 15 heating heat VBG cord-005146-o3roa7br 162 16 ( ( -LRB- cord-005146-o3roa7br 162 17 Hahn Hahn NNP cord-005146-o3roa7br 162 18 , , , cord-005146-o3roa7br 162 19 1982 1982 CD cord-005146-o3roa7br 162 20 ) ) -RRB- cord-005146-o3roa7br 162 21 . . . cord-005146-o3roa7br 163 1 The the DT cord-005146-o3roa7br 163 2 finding finding NN cord-005146-o3roa7br 163 3 that that IN cord-005146-o3roa7br 163 4 the the DT cord-005146-o3roa7br 163 5 glial glial JJ cord-005146-o3roa7br 163 6 cells cell NNS cord-005146-o3roa7br 163 7 and and CC cord-005146-o3roa7br 163 8 associated associated JJ cord-005146-o3roa7br 163 9 myelin myelin NN cord-005146-o3roa7br 163 10 sheaths sheath NNS cord-005146-o3roa7br 163 11 were be VBD cord-005146-o3roa7br 163 12 more more RBR cord-005146-o3roa7br 163 13 vulnerable vulnerable JJ cord-005146-o3roa7br 163 14 to to IN cord-005146-o3roa7br 163 15 heat heat NN cord-005146-o3roa7br 163 16 treatment treatment NN cord-005146-o3roa7br 163 17 than than IN cord-005146-o3roa7br 163 18 axons axon NNS cord-005146-o3roa7br 163 19 is be VBZ cord-005146-o3roa7br 163 20 in in IN cord-005146-o3roa7br 163 21 contrast contrast NN cord-005146-o3roa7br 163 22 to to IN cord-005146-o3roa7br 163 23 previous previous JJ cord-005146-o3roa7br 163 24 studies study NNS cord-005146-o3roa7br 163 25 using use VBG cord-005146-o3roa7br 163 26 ultrasound ultrasound NN cord-005146-o3roa7br 163 27 for for IN cord-005146-o3roa7br 163 28 heating heating NN cord-005146-o3roa7br 163 29 ( ( -LRB- cord-005146-o3roa7br 163 30 Fry Fry NNP cord-005146-o3roa7br 163 31 et et NNP cord-005146-o3roa7br 163 32 al al NNP cord-005146-o3roa7br 163 33 . . NNP cord-005146-o3roa7br 163 34 , , , cord-005146-o3roa7br 163 35 1955 1955 CD cord-005146-o3roa7br 163 36 ; ; : cord-005146-o3roa7br 163 37 Barnard Barnard NNP cord-005146-o3roa7br 163 38 et et NNP cord-005146-o3roa7br 163 39 al al NNP cord-005146-o3roa7br 163 40 . . NNP cord-005146-o3roa7br 163 41 , , , cord-005146-o3roa7br 163 42 1956 1956 CD cord-005146-o3roa7br 163 43 ) ) -RRB- cord-005146-o3roa7br 163 44 which which WDT cord-005146-o3roa7br 163 45 claimed claim VBD cord-005146-o3roa7br 163 46 that that IN cord-005146-o3roa7br 163 47 axons axon NNS cord-005146-o3roa7br 163 48 were be VBD cord-005146-o3roa7br 163 49 more more RBR cord-005146-o3roa7br 163 50 vulnerable vulnerable JJ cord-005146-o3roa7br 163 51 to to IN cord-005146-o3roa7br 163 52 heat heat NN cord-005146-o3roa7br 163 53 injury injury NN cord-005146-o3roa7br 163 54 than than IN cord-005146-o3roa7br 163 55 glial glial JJ cord-005146-o3roa7br 163 56 ceils ceil NNS cord-005146-o3roa7br 163 57 . . . cord-005146-o3roa7br 164 1 The the DT cord-005146-o3roa7br 164 2 discrepancy discrepancy NN cord-005146-o3roa7br 164 3 in in IN cord-005146-o3roa7br 164 4 the the DT cord-005146-o3roa7br 164 5 vulnerability vulnerability NN cord-005146-o3roa7br 164 6 between between IN cord-005146-o3roa7br 164 7 axons axon NNS cord-005146-o3roa7br 164 8 and and CC cord-005146-o3roa7br 164 9 glial glial JJ cord-005146-o3roa7br 164 10 cells cell NNS cord-005146-o3roa7br 164 11 between between IN cord-005146-o3roa7br 164 12 their -PRON- PRP$ cord-005146-o3roa7br 164 13 studies study NNS cord-005146-o3roa7br 164 14 and and CC cord-005146-o3roa7br 164 15 our -PRON- PRP$ cord-005146-o3roa7br 164 16 own own JJ cord-005146-o3roa7br 164 17 may may MD cord-005146-o3roa7br 164 18 be be VB cord-005146-o3roa7br 164 19 due due JJ cord-005146-o3roa7br 164 20 to to IN cord-005146-o3roa7br 164 21 the the DT cord-005146-o3roa7br 164 22 different different JJ cord-005146-o3roa7br 164 23 methods method NNS cord-005146-o3roa7br 164 24 employed employ VBN cord-005146-o3roa7br 164 25 . . . cord-005146-o3roa7br 165 1 The the DT cord-005146-o3roa7br 165 2 conductivity conductivity NN cord-005146-o3roa7br 165 3 and and CC cord-005146-o3roa7br 165 4 absorption absorption NN cord-005146-o3roa7br 165 5 rate rate NN cord-005146-o3roa7br 165 6 of of IN cord-005146-o3roa7br 165 7 the the DT cord-005146-o3roa7br 165 8 heat heat NN cord-005146-o3roa7br 165 9 in in IN cord-005146-o3roa7br 165 10 the the DT cord-005146-o3roa7br 165 11 CNS CNS NNP cord-005146-o3roa7br 165 12 tissues tissue NNS cord-005146-o3roa7br 165 13 would would MD cord-005146-o3roa7br 165 14 be be VB cord-005146-o3roa7br 165 15 different different JJ cord-005146-o3roa7br 165 16 in in IN cord-005146-o3roa7br 165 17 the the DT cord-005146-o3roa7br 165 18 two two CD cord-005146-o3roa7br 165 19 methods method NNS cord-005146-o3roa7br 165 20 which which WDT cord-005146-o3roa7br 165 21 could could MD cord-005146-o3roa7br 165 22 produce produce VB cord-005146-o3roa7br 165 23 different different JJ cord-005146-o3roa7br 165 24 effects effect NNS cord-005146-o3roa7br 165 25 on on IN cord-005146-o3roa7br 165 26 axons axon NNS cord-005146-o3roa7br 165 27 and and CC cord-005146-o3roa7br 165 28 on on IN cord-005146-o3roa7br 165 29 glial glial JJ cord-005146-o3roa7br 165 30 cells cell NNS cord-005146-o3roa7br 165 31 . . . cord-005146-o3roa7br 166 1 Primary primary JJ cord-005146-o3roa7br 166 2 demyelination demyelination NN cord-005146-o3roa7br 166 3 in in IN cord-005146-o3roa7br 166 4 the the DT cord-005146-o3roa7br 166 5 CNS CNS NNP cord-005146-o3roa7br 166 6 occurs occur VBZ cord-005146-o3roa7br 166 7 in in IN cord-005146-o3roa7br 166 8 multiple multiple JJ cord-005146-o3roa7br 166 9 sclerosis sclerosis NN cord-005146-o3roa7br 166 10 and and CC cord-005146-o3roa7br 166 11 experimental experimental JJ cord-005146-o3roa7br 166 12 infection infection NN cord-005146-o3roa7br 166 13 of of IN cord-005146-o3roa7br 166 14 Theiler Theiler NNP cord-005146-o3roa7br 166 15 's 's POS cord-005146-o3roa7br 166 16 murine murine JJ cord-005146-o3roa7br 166 17 encephalomyelitis encephalomyelitis NN cord-005146-o3roa7br 166 18 ( ( -LRB- cord-005146-o3roa7br 166 19 TME TME NNP cord-005146-o3roa7br 166 20 ) ) -RRB- cord-005146-o3roa7br 166 21 virus virus NN cord-005146-o3roa7br 166 22 ( ( -LRB- cord-005146-o3roa7br 166 23 Dal Dal NNP cord-005146-o3roa7br 166 24 Canto Canto NNP cord-005146-o3roa7br 166 25 & & CC cord-005146-o3roa7br 166 26 Lipton Lipton NNP cord-005146-o3roa7br 166 27 , , , cord-005146-o3roa7br 166 28 1980 1980 CD cord-005146-o3roa7br 166 29 ; ; : cord-005146-o3roa7br 166 30 Dal Dal NNP cord-005146-o3roa7br 166 31 Canto Canto NNP cord-005146-o3roa7br 166 32 & & CC cord-005146-o3roa7br 166 33 Barbano Barbano NNP cord-005146-o3roa7br 166 34 , , , cord-005146-o3roa7br 166 35 1984 1984 CD cord-005146-o3roa7br 166 36 ) ) -RRB- cord-005146-o3roa7br 166 37 as as RB cord-005146-o3roa7br 166 38 well well RB cord-005146-o3roa7br 166 39 as as IN cord-005146-o3roa7br 166 40 in in IN cord-005146-o3roa7br 166 41 other other JJ cord-005146-o3roa7br 166 42 experimental experimental JJ cord-005146-o3roa7br 166 43 injuries injury NNS cord-005146-o3roa7br 166 44 using use VBG cord-005146-o3roa7br 166 45 lysophosphatidylcholine lysophosphatidylcholine NNP cord-005146-o3roa7br 166 46 ( ( -LRB- cord-005146-o3roa7br 166 47 LCP lcp NN cord-005146-o3roa7br 166 48 ) ) -RRB- cord-005146-o3roa7br 166 49 ( ( -LRB- cord-005146-o3roa7br 166 50 Blakemore Blakemore NNP cord-005146-o3roa7br 166 51 , , , cord-005146-o3roa7br 166 52 1976 1976 CD cord-005146-o3roa7br 166 53 ) ) -RRB- cord-005146-o3roa7br 166 54 , , , cord-005146-o3roa7br 166 55 6-aminonicotinamide 6-aminonicotinamide CD cord-005146-o3roa7br 166 56 ( ( -LRB- cord-005146-o3roa7br 166 57 6-AN 6-an CD cord-005146-o3roa7br 166 58 ) ) -RRB- cord-005146-o3roa7br 167 1 ( ( -LRB- cord-005146-o3roa7br 167 2 Blakemore Blakemore NNP cord-005146-o3roa7br 167 3 , , , cord-005146-o3roa7br 167 4 1975 1975 CD cord-005146-o3roa7br 167 5 ) ) -RRB- cord-005146-o3roa7br 167 6 , , , cord-005146-o3roa7br 167 7 Cuprizone Cuprizone NNP cord-005146-o3roa7br 167 8 ( ( -LRB- cord-005146-o3roa7br 167 9 Ludwin Ludwin NNP cord-005146-o3roa7br 167 10 , , , cord-005146-o3roa7br 167 11 1978 1978 CD cord-005146-o3roa7br 167 12 ) ) -RRB- cord-005146-o3roa7br 167 13 and and CC cord-005146-o3roa7br 167 14 CSF CSF NNP cord-005146-o3roa7br 167 15 barbotage barbotage NNP cord-005146-o3roa7br 167 16 ( ( -LRB- cord-005146-o3roa7br 167 17 Bunge Bunge NNP cord-005146-o3roa7br 167 18 et et NNP cord-005146-o3roa7br 167 19 aI. ai. NN cord-005146-o3roa7br 167 20 , , , cord-005146-o3roa7br 167 21 1960 1960 CD cord-005146-o3roa7br 167 22 ) ) -RRB- cord-005146-o3roa7br 167 23 , , , cord-005146-o3roa7br 167 24 whereas whereas IN cord-005146-o3roa7br 167 25 in in IN cord-005146-o3roa7br 167 26 other other JJ cord-005146-o3roa7br 167 27 experimental experimental JJ cord-005146-o3roa7br 167 28 injuries injury NNS cord-005146-o3roa7br 167 29 such such JJ cord-005146-o3roa7br 167 30 as as IN cord-005146-o3roa7br 167 31 allergic allergic JJ cord-005146-o3roa7br 167 32 ence- ence- NNS cord-005146-o3roa7br 168 1 Fig Fig NNP cord-005146-o3roa7br 168 2 . . . cord-005146-o3roa7br 169 1 8 8 CD cord-005146-o3roa7br 169 2 . . . cord-005146-o3roa7br 170 1 One one CD cord-005146-o3roa7br 170 2 month month NN cord-005146-o3roa7br 170 3 after after IN cord-005146-o3roa7br 170 4 treatment treatment NN cord-005146-o3roa7br 170 5 . . . cord-005146-o3roa7br 171 1 This this DT cord-005146-o3roa7br 171 2 electron electron NN cord-005146-o3roa7br 171 3 micrograph micrograph NN cord-005146-o3roa7br 171 4 shows show VBZ cord-005146-o3roa7br 171 5 the the DT cord-005146-o3roa7br 171 6 subpial subpial JJ cord-005146-o3roa7br 171 7 area area NN cord-005146-o3roa7br 171 8 of of IN cord-005146-o3roa7br 171 9 the the DT cord-005146-o3roa7br 171 10 lesion lesion NN cord-005146-o3roa7br 171 11 . . . cord-005146-o3roa7br 172 1 All all PDT cord-005146-o3roa7br 172 2 the the DT cord-005146-o3roa7br 172 3 axons axon NNS cord-005146-o3roa7br 172 4 ( ( -LRB- cord-005146-o3roa7br 172 5 Ax)are ax)are VBP cord-005146-o3roa7br 172 6 thickly thickly RB cord-005146-o3roa7br 172 7 myelinated myelinate VBN cord-005146-o3roa7br 172 8 by by IN cord-005146-o3roa7br 172 9 Schwann Schwann NNP cord-005146-o3roa7br 172 10 cells cell NNS cord-005146-o3roa7br 172 11 ( ( -LRB- cord-005146-o3roa7br 172 12 S s NN cord-005146-o3roa7br 172 13 ) ) -RRB- cord-005146-o3roa7br 172 14 . . . cord-005146-o3roa7br 173 1 There there EX cord-005146-o3roa7br 173 2 is be VBZ cord-005146-o3roa7br 173 3 no no DT cord-005146-o3roa7br 173 4 typical typical JJ cord-005146-o3roa7br 173 5 GLM glm NN cord-005146-o3roa7br 173 6 at at IN cord-005146-o3roa7br 173 7 the the DT cord-005146-o3roa7br 173 8 surface surface NN cord-005146-o3roa7br 173 9 which which WDT cord-005146-o3roa7br 173 10 is be VBZ cord-005146-o3roa7br 173 11 covered cover VBN cord-005146-o3roa7br 173 12 by by IN cord-005146-o3roa7br 173 13 a a DT cord-005146-o3roa7br 173 14 thick thick JJ cord-005146-o3roa7br 173 15 cell cell NN cord-005146-o3roa7br 173 16 layer layer NN cord-005146-o3roa7br 173 17 ( ( -LRB- cord-005146-o3roa7br 173 18 P p NN cord-005146-o3roa7br 173 19 ) ) -RRB- cord-005146-o3roa7br 173 20 . . . cord-005146-o3roa7br 174 1 x x LS cord-005146-o3roa7br 174 2 7400 7400 CD cord-005146-o3roa7br 174 3 . . . cord-005146-o3roa7br 175 1 phalomyelitis phalomyelitis NNP cord-005146-o3roa7br 175 2 ( ( -LRB- cord-005146-o3roa7br 175 3 EAE EAE NNP cord-005146-o3roa7br 175 4 ) ) -RRB- cord-005146-o3roa7br 175 5 ( ( -LRB- cord-005146-o3roa7br 175 6 Lampert Lampert NNP cord-005146-o3roa7br 175 7 , , , cord-005146-o3roa7br 175 8 1967 1967 CD cord-005146-o3roa7br 175 9 ) ) -RRB- cord-005146-o3roa7br 175 10 , , , cord-005146-o3roa7br 175 11 diphtheria diphtheria NN cord-005146-o3roa7br 175 12 toxin toxin NN cord-005146-o3roa7br 175 13 injection injection NN cord-005146-o3roa7br 176 1 ( ( -LRB- cord-005146-o3roa7br 176 2 Harrison Harrison NNP cord-005146-o3roa7br 176 3 et et NNP cord-005146-o3roa7br 176 4 aI. aI. NNP cord-005146-o3roa7br 176 5 , , , cord-005146-o3roa7br 176 6 1972 1972 CD cord-005146-o3roa7br 176 7 ) ) -RRB- cord-005146-o3roa7br 176 8 , , , cord-005146-o3roa7br 176 9 and and CC cord-005146-o3roa7br 176 10 impact impact NN cord-005146-o3roa7br 176 11 injury injury NN cord-005146-o3roa7br 176 12 ( ( -LRB- cord-005146-o3roa7br 176 13 Griffith Griffith NNP cord-005146-o3roa7br 176 14 & & CC cord-005146-o3roa7br 176 15 McCulloch McCulloch NNP cord-005146-o3roa7br 176 16 , , , cord-005146-o3roa7br 176 17 1983 1983 CD cord-005146-o3roa7br 176 18 ) ) -RRB- cord-005146-o3roa7br 176 19 , , , cord-005146-o3roa7br 176 20 axons axon NNS cord-005146-o3roa7br 176 21 also also RB cord-005146-o3roa7br 176 22 undergo undergo VBP cord-005146-o3roa7br 176 23 degenerative degenerative JJ cord-005146-o3roa7br 176 24 changes change NNS cord-005146-o3roa7br 176 25 . . . cord-005146-o3roa7br 177 1 In in IN cord-005146-o3roa7br 177 2 these these DT cord-005146-o3roa7br 177 3 latter latter JJ cord-005146-o3roa7br 177 4 disorders disorder NNS cord-005146-o3roa7br 177 5 severe severe JJ cord-005146-o3roa7br 177 6 vasogenic vasogenic NNP cord-005146-o3roa7br 177 7 oedema oedema NN cord-005146-o3roa7br 177 8 and and CC cord-005146-o3roa7br 177 9 local local JJ cord-005146-o3roa7br 177 10 haemorrhage haemorrhage NN cord-005146-o3roa7br 177 11 occur occur VBP cord-005146-o3roa7br 177 12 , , , cord-005146-o3roa7br 177 13 which which WDT cord-005146-o3roa7br 177 14 are be VBP cord-005146-o3roa7br 177 15 considered consider VBN cord-005146-o3roa7br 177 16 to to TO cord-005146-o3roa7br 177 17 be be VB cord-005146-o3roa7br 177 18 harmful harmful JJ cord-005146-o3roa7br 177 19 to to IN cord-005146-o3roa7br 177 20 axons axon NNS cord-005146-o3roa7br 177 21 , , , cord-005146-o3roa7br 177 22 and and CC cord-005146-o3roa7br 177 23 thus thus RB cord-005146-o3roa7br 177 24 may may MD cord-005146-o3roa7br 177 25 be be VB cord-005146-o3roa7br 177 26 partly partly RB cord-005146-o3roa7br 177 27 responsible responsible JJ cord-005146-o3roa7br 177 28 for for IN cord-005146-o3roa7br 177 29 axonal axonal JJ cord-005146-o3roa7br 177 30 degeneration degeneration NN cord-005146-o3roa7br 177 31 . . . cord-005146-o3roa7br 178 1 It -PRON- PRP cord-005146-o3roa7br 178 2 seems seem VBZ cord-005146-o3roa7br 178 3 that that IN cord-005146-o3roa7br 178 4 heat heat NN cord-005146-o3roa7br 178 5 treatment treatment NN cord-005146-o3roa7br 178 6 does do VBZ cord-005146-o3roa7br 178 7 not not RB cord-005146-o3roa7br 178 8 produce produce VB cord-005146-o3roa7br 178 9 damage damage NN cord-005146-o3roa7br 178 10 of of IN cord-005146-o3roa7br 178 11 sufficient sufficient JJ cord-005146-o3roa7br 178 12 severity severity NN cord-005146-o3roa7br 178 13 to to IN cord-005146-o3roa7br 178 14 the the DT cord-005146-o3roa7br 178 15 blood blood NN cord-005146-o3roa7br 178 16 - - HYPH cord-005146-o3roa7br 178 17 brain brain NN cord-005146-o3roa7br 178 18 barrier barrier NN cord-005146-o3roa7br 178 19 ( ( -LRB- cord-005146-o3roa7br 178 20 BBB BBB NNP cord-005146-o3roa7br 178 21 ) ) -RRB- cord-005146-o3roa7br 178 22 so so IN cord-005146-o3roa7br 178 23 as as IN cord-005146-o3roa7br 178 24 to to TO cord-005146-o3roa7br 178 25 fatally fatally RB cord-005146-o3roa7br 178 26 affect affect VB cord-005146-o3roa7br 178 27 the the DT cord-005146-o3roa7br 178 28 axons axon NNS cord-005146-o3roa7br 178 29 , , , cord-005146-o3roa7br 178 30 although although IN cord-005146-o3roa7br 178 31 permeability permeability NN cord-005146-o3roa7br 178 32 of of IN cord-005146-o3roa7br 178 33 damaged damage VBN cord-005146-o3roa7br 178 34 blood blood NN cord-005146-o3roa7br 178 35 vessels vessel NNS cord-005146-o3roa7br 178 36 seemed seem VBD cord-005146-o3roa7br 178 37 to to TO cord-005146-o3roa7br 178 38 increase increase VB cord-005146-o3roa7br 178 39 to to IN cord-005146-o3roa7br 178 40 a a DT cord-005146-o3roa7br 178 41 certain certain JJ cord-005146-o3roa7br 178 42 degree degree NN cord-005146-o3roa7br 178 43 ( ( -LRB- cord-005146-o3roa7br 178 44 Muel!er Muel!er NNP cord-005146-o3roa7br 178 45 , , , cord-005146-o3roa7br 178 46 1979 1979 CD cord-005146-o3roa7br 178 47 ) ) -RRB- cord-005146-o3roa7br 178 48 . . . cord-005146-o3roa7br 179 1 It -PRON- PRP cord-005146-o3roa7br 179 2 was be VBD cord-005146-o3roa7br 179 3 shown show VBN cord-005146-o3roa7br 179 4 in in IN cord-005146-o3roa7br 179 5 the the DT cord-005146-o3roa7br 179 6 present present JJ cord-005146-o3roa7br 179 7 study study NN cord-005146-o3roa7br 179 8 that that WDT cord-005146-o3roa7br 179 9 demyelinated demyelinate VBD cord-005146-o3roa7br 179 10 axons axon NNS cord-005146-o3roa7br 179 11 are be VBP cord-005146-o3roa7br 179 12 effectively effectively RB cord-005146-o3roa7br 179 13 remyelinated remyelinate VBN cord-005146-o3roa7br 179 14 by by IN cord-005146-o3roa7br 179 15 either either DT cord-005146-o3roa7br 179 16 oligo oligo NN cord-005146-o3roa7br 179 17 - - HYPH cord-005146-o3roa7br 179 18 dendrocytes dendrocyte NNS cord-005146-o3roa7br 179 19 or or CC cord-005146-o3roa7br 179 20 Schwann Schwann NNP cord-005146-o3roa7br 179 21 cells cell NNS cord-005146-o3roa7br 179 22 . . . cord-005146-o3roa7br 180 1 The the DT cord-005146-o3roa7br 180 2 same same JJ cord-005146-o3roa7br 180 3 pattern pattern NN cord-005146-o3roa7br 180 4 of of IN cord-005146-o3roa7br 180 5 remyelination remyelination NN cord-005146-o3roa7br 180 6 by by IN cord-005146-o3roa7br 180 7 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 180 8 and and CC cord-005146-o3roa7br 180 9 Schwann Schwann NNP cord-005146-o3roa7br 180 10 cells cell NNS cord-005146-o3roa7br 180 11 has have VBZ cord-005146-o3roa7br 180 12 also also RB cord-005146-o3roa7br 180 13 been be VBN cord-005146-o3roa7br 180 14 noted note VBN cord-005146-o3roa7br 180 15 in in IN cord-005146-o3roa7br 180 16 CNS CNS NNP cord-005146-o3roa7br 180 17 lesions lesion NNS cord-005146-o3roa7br 180 18 induced induce VBN cord-005146-o3roa7br 180 19 by by IN cord-005146-o3roa7br 180 20 the the DT cord-005146-o3roa7br 180 21 murine murine JJ cord-005146-o3roa7br 180 22 corona corona NN cord-005146-o3roa7br 180 23 ( ( -LRB- cord-005146-o3roa7br 180 24 JHM JHM NNP cord-005146-o3roa7br 180 25 ) ) -RRB- cord-005146-o3roa7br 180 26 virus virus NN cord-005146-o3roa7br 180 27 ( ( -LRB- cord-005146-o3roa7br 180 28 Nagashima Nagashima NNP cord-005146-o3roa7br 180 29 et et NNP cord-005146-o3roa7br 180 30 al al NNP cord-005146-o3roa7br 180 31 . . NNP cord-005146-o3roa7br 180 32 , , , cord-005146-o3roa7br 180 33 1979 1979 CD cord-005146-o3roa7br 180 34 ) ) -RRB- cord-005146-o3roa7br 180 35 , , , cord-005146-o3roa7br 180 36 the the DT cord-005146-o3roa7br 180 37 TME TME NNP cord-005146-o3roa7br 180 38 virus virus NN cord-005146-o3roa7br 180 39 ( ( -LRB- cord-005146-o3roa7br 180 40 Dal Dal NNP cord-005146-o3roa7br 180 41 Canto Canto NNP cord-005146-o3roa7br 180 42 & & CC cord-005146-o3roa7br 180 43 Barbano Barbano NNP cord-005146-o3roa7br 180 44 , , , cord-005146-o3roa7br 180 45 1984 1984 CD cord-005146-o3roa7br 180 46 ) ) -RRB- cord-005146-o3roa7br 180 47 , , , cord-005146-o3roa7br 180 48 and and CC cord-005146-o3roa7br 180 49 cryo cryo NN cord-005146-o3roa7br 180 50 - - HYPH cord-005146-o3roa7br 180 51 treatment treatment NN cord-005146-o3roa7br 180 52 ( ( -LRB- cord-005146-o3roa7br 180 53 Collins Collins NNP cord-005146-o3roa7br 180 54 et et NNP cord-005146-o3roa7br 180 55 al al NNP cord-005146-o3roa7br 180 56 . . NNP cord-005146-o3roa7br 180 57 , , , cord-005146-o3roa7br 180 58 1986 1986 CD cord-005146-o3roa7br 180 59 ; ; : cord-005146-o3roa7br 180 60 our -PRON- PRP$ cord-005146-o3roa7br 180 61 unpublished unpublished JJ cord-005146-o3roa7br 180 62 observations observation NNS cord-005146-o3roa7br 180 63 ) ) -RRB- cord-005146-o3roa7br 180 64 as as RB cord-005146-o3roa7br 180 65 well well RB cord-005146-o3roa7br 180 66 as as IN cord-005146-o3roa7br 180 67 by by IN cord-005146-o3roa7br 180 68 X x NN cord-005146-o3roa7br 180 69 - - NN cord-005146-o3roa7br 180 70 ray ray JJ cord-005146-o3roa7br 180 71 irradiation irradiation NN cord-005146-o3roa7br 180 72 of of IN cord-005146-o3roa7br 180 73 the the DT cord-005146-o3roa7br 180 74 infant infant NN cord-005146-o3roa7br 180 75 spinal spinal JJ cord-005146-o3roa7br 180 76 cord cord NN cord-005146-o3roa7br 180 77 ( ( -LRB- cord-005146-o3roa7br 180 78 Gilmore Gilmore NNP cord-005146-o3roa7br 180 79 & & CC cord-005146-o3roa7br 180 80 Duncan Duncan NNP cord-005146-o3roa7br 180 81 , , , cord-005146-o3roa7br 180 82 1968 1968 CD cord-005146-o3roa7br 180 83 ; ; : cord-005146-o3roa7br 180 84 Blakemore Blakemore NNP cord-005146-o3roa7br 180 85 & & CC cord-005146-o3roa7br 180 86 Patterson Patterson NNP cord-005146-o3roa7br 180 87 , , , cord-005146-o3roa7br 180 88 1975 1975 CD cord-005146-o3roa7br 180 89 ; ; : cord-005146-o3roa7br 180 90 Gilmore Gilmore NNP cord-005146-o3roa7br 180 91 & & CC cord-005146-o3roa7br 180 92 Sims Sims NNP cord-005146-o3roa7br 180 93 , , , cord-005146-o3roa7br 180 94 1986 1986 CD cord-005146-o3roa7br 180 95 ) ) -RRB- cord-005146-o3roa7br 180 96 . . . cord-005146-o3roa7br 181 1 Remyelination remyelination NN cord-005146-o3roa7br 181 2 by by IN cord-005146-o3roa7br 181 3 Schwann Schwann NNP cord-005146-o3roa7br 181 4 cells cell NNS cord-005146-o3roa7br 181 5 is be VBZ cord-005146-o3roa7br 181 6 predominant predominant JJ cord-005146-o3roa7br 181 7 in in IN cord-005146-o3roa7br 181 8 6-AN 6-an CD cord-005146-o3roa7br 182 1 ( ( -LRB- cord-005146-o3roa7br 182 2 Blakemore Blakemore NNP cord-005146-o3roa7br 182 3 , , , cord-005146-o3roa7br 182 4 1975 1975 CD cord-005146-o3roa7br 182 5 ) ) -RRB- cord-005146-o3roa7br 182 6 and and CC cord-005146-o3roa7br 182 7 ethidium ethidium NN cord-005146-o3roa7br 182 8 bromide bromide NN cord-005146-o3roa7br 182 9 injected inject VBN cord-005146-o3roa7br 182 10 CNS CNS NNP cord-005146-o3roa7br 182 11 ( ( -LRB- cord-005146-o3roa7br 182 12 Blakemore Blakemore NNP cord-005146-o3roa7br 182 13 , , , cord-005146-o3roa7br 182 14 1982 1982 CD cord-005146-o3roa7br 182 15 ; ; : cord-005146-o3roa7br 183 1 Gra#a Gra#a NNP cord-005146-o3roa7br 183 2 & & CC cord-005146-o3roa7br 183 3 Blakemore Blakemore NNP cord-005146-o3roa7br 183 4 , , , cord-005146-o3roa7br 183 5 1986 1986 CD cord-005146-o3roa7br 183 6 ) ) -RRB- cord-005146-o3roa7br 183 7 , , , cord-005146-o3roa7br 183 8 whereas whereas IN cord-005146-o3roa7br 183 9 remyelination remyelination NN cord-005146-o3roa7br 183 10 by by IN cord-005146-o3roa7br 183 11 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 183 12 is be VBZ cord-005146-o3roa7br 183 13 prominent prominent JJ cord-005146-o3roa7br 183 14 in in IN cord-005146-o3roa7br 183 15 ordinary ordinary JJ cord-005146-o3roa7br 183 16 EAE EAE NNP cord-005146-o3roa7br 183 17 ( ( -LRB- cord-005146-o3roa7br 183 18 Lampert Lampert NNP cord-005146-o3roa7br 183 19 , , , cord-005146-o3roa7br 183 20 1965 1965 CD cord-005146-o3roa7br 183 21 ( ( -LRB- cord-005146-o3roa7br 183 22 Lampert Lampert NNP cord-005146-o3roa7br 183 23 , , , cord-005146-o3roa7br 183 24 , , , cord-005146-o3roa7br 183 25 1967 1967 CD cord-005146-o3roa7br 183 26 and and CC cord-005146-o3roa7br 183 27 Cuprizone Cuprizone NNP cord-005146-o3roa7br 183 28 treatment treatment NN cord-005146-o3roa7br 183 29 ( ( -LRB- cord-005146-o3roa7br 183 30 Ludwin Ludwin NNP cord-005146-o3roa7br 183 31 , , , cord-005146-o3roa7br 183 32 1978 1978 CD cord-005146-o3roa7br 183 33 ) ) -RRB- cord-005146-o3roa7br 183 34 . . . cord-005146-o3roa7br 184 1 It -PRON- PRP cord-005146-o3roa7br 184 2 should should MD cord-005146-o3roa7br 184 3 be be VB cord-005146-o3roa7br 184 4 noted note VBN cord-005146-o3roa7br 184 5 that that IN cord-005146-o3roa7br 184 6 Schwann Schwann NNP cord-005146-o3roa7br 184 7 cell cell NN cord-005146-o3roa7br 184 8 - - HYPH cord-005146-o3roa7br 184 9 remyelination remyelination NN cord-005146-o3roa7br 184 10 was be VBD cord-005146-o3roa7br 184 11 dominant dominant JJ cord-005146-o3roa7br 184 12 in in IN cord-005146-o3roa7br 184 13 the the DT cord-005146-o3roa7br 184 14 subpial subpial JJ cord-005146-o3roa7br 184 15 and and CC cord-005146-o3roa7br 184 16 perivascular perivascular JJ cord-005146-o3roa7br 184 17 areas area NNS cord-005146-o3roa7br 184 18 , , , cord-005146-o3roa7br 184 19 Fig Fig NNP cord-005146-o3roa7br 184 20 . . . cord-005146-o3roa7br 185 1 9 9 LS cord-005146-o3roa7br 185 2 . . . cord-005146-o3roa7br 186 1 One one CD cord-005146-o3roa7br 186 2 month month NN cord-005146-o3roa7br 186 3 after after IN cord-005146-o3roa7br 186 4 treatment treatment NN cord-005146-o3roa7br 186 5 . . . cord-005146-o3roa7br 187 1 This this DT cord-005146-o3roa7br 187 2 electron electron NN cord-005146-o3roa7br 187 3 micrograph micrograph NN cord-005146-o3roa7br 187 4 shows show VBZ cord-005146-o3roa7br 187 5 the the DT cord-005146-o3roa7br 187 6 deep deep JJ cord-005146-o3roa7br 187 7 zone zone NN cord-005146-o3roa7br 187 8 bordering border VBG cord-005146-o3roa7br 187 9 the the DT cord-005146-o3roa7br 187 10 intact intact JJ cord-005146-o3roa7br 187 11 areas area NNS cord-005146-o3roa7br 187 12 . . . cord-005146-o3roa7br 188 1 Most Most JJS cord-005146-o3roa7br 188 2 axons axon NNS cord-005146-o3roa7br 188 3 ( ( -LRB- cord-005146-o3roa7br 188 4 Ax ax NN cord-005146-o3roa7br 188 5 ) ) -RRB- cord-005146-o3roa7br 188 6 have have VB cord-005146-o3roa7br 188 7 CNS CNS NNP cord-005146-o3roa7br 188 8 - - HYPH cord-005146-o3roa7br 188 9 type type NN cord-005146-o3roa7br 188 10 myelin myelin NN cord-005146-o3roa7br 188 11 sheaths sheath NNS cord-005146-o3roa7br 188 12 , , , cord-005146-o3roa7br 188 13 that that RB cord-005146-o3roa7br 188 14 is is RB cord-005146-o3roa7br 188 15 , , , cord-005146-o3roa7br 188 16 they -PRON- PRP cord-005146-o3roa7br 188 17 have have VBP cord-005146-o3roa7br 188 18 been be VBN cord-005146-o3roa7br 188 19 myelinated myelinate VBN cord-005146-o3roa7br 188 20 by by IN cord-005146-o3roa7br 188 21 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 188 22 , , , cord-005146-o3roa7br 188 23 but but CC cord-005146-o3roa7br 188 24 their -PRON- PRP$ cord-005146-o3roa7br 188 25 myelin myelin JJ cord-005146-o3roa7br 188 26 sheaths sheath NNS cord-005146-o3roa7br 188 27 are be VBP cord-005146-o3roa7br 188 28 still still RB cord-005146-o3roa7br 188 29 very very RB cord-005146-o3roa7br 188 30 thin thin JJ cord-005146-o3roa7br 188 31 . . . cord-005146-o3roa7br 189 1 The the DT cord-005146-o3roa7br 189 2 axons axon NNS cord-005146-o3roa7br 189 3 with with IN cord-005146-o3roa7br 189 4 thick thick JJ cord-005146-o3roa7br 189 5 myelin myelin NN cord-005146-o3roa7br 189 6 sheaths sheath NNS cord-005146-o3roa7br 189 7 ( ( -LRB- cord-005146-o3roa7br 189 8 C C NNP cord-005146-o3roa7br 189 9 ) ) -RRB- cord-005146-o3roa7br 189 10 are be VBP cord-005146-o3roa7br 189 11 those those DT cord-005146-o3roa7br 189 12 that that WDT cord-005146-o3roa7br 189 13 were be VBD cord-005146-o3roa7br 189 14 unaffected unaffected JJ cord-005146-o3roa7br 189 15 by by IN cord-005146-o3roa7br 189 16 heat heat NN cord-005146-o3roa7br 189 17 injury injury NN cord-005146-o3roa7br 189 18 . . . cord-005146-o3roa7br 190 1 As as IN cord-005146-o3roa7br 190 2 : : : cord-005146-o3roa7br 190 3 astrocyte astrocyte NNP cord-005146-o3roa7br 190 4 , , , cord-005146-o3roa7br 190 5 x x NN cord-005146-o3roa7br 190 6 7800 7800 CD cord-005146-o3roa7br 190 7 . . . cord-005146-o3roa7br 191 1 whereas whereas IN cord-005146-o3roa7br 191 2 oligodendrocyte oligodendrocyte NNP cord-005146-o3roa7br 191 3 - - HYPH cord-005146-o3roa7br 191 4 remyelination remyelination NN cord-005146-o3roa7br 191 5 was be VBD cord-005146-o3roa7br 191 6 conspicuous conspicuous JJ cord-005146-o3roa7br 191 7 in in IN cord-005146-o3roa7br 191 8 the the DT cord-005146-o3roa7br 191 9 deep deep JJ cord-005146-o3roa7br 191 10 and and CC cord-005146-o3roa7br 191 11 border border NN cord-005146-o3roa7br 191 12 areas area NNS cord-005146-o3roa7br 191 13 of of IN cord-005146-o3roa7br 191 14 a a DT cord-005146-o3roa7br 191 15 lesion lesion NN cord-005146-o3roa7br 191 16 . . . cord-005146-o3roa7br 192 1 The the DT cord-005146-o3roa7br 192 2 appearance appearance NN cord-005146-o3roa7br 192 3 o o XX cord-005146-o3roa7br 192 4 f f LS cord-005146-o3roa7br 192 5 Schwann Schwann NNP cord-005146-o3roa7br 192 6 cells cell NNS cord-005146-o3roa7br 192 7 in in IN cord-005146-o3roa7br 192 8 the the DT cord-005146-o3roa7br 192 9 CNS CNS NNP cord-005146-o3roa7br 192 10 has have VBZ cord-005146-o3roa7br 192 11 been be VBN cord-005146-o3roa7br 192 12 controversial controversial JJ cord-005146-o3roa7br 192 13 and and CC cord-005146-o3roa7br 192 14 various various JJ cord-005146-o3roa7br 192 15 prerequisites prerequisite NNS cord-005146-o3roa7br 192 16 for for IN cord-005146-o3roa7br 192 17 ectopic ectopic JJ cord-005146-o3roa7br 192 18 Schwann Schwann NNP cord-005146-o3roa7br 192 19 cells cell NNS cord-005146-o3roa7br 192 20 in in IN cord-005146-o3roa7br 192 21 the the DT cord-005146-o3roa7br 192 22 CNS CNS NNP cord-005146-o3roa7br 192 23 have have VBP cord-005146-o3roa7br 192 24 been be VBN cord-005146-o3roa7br 192 25 proposed propose VBN cord-005146-o3roa7br 192 26 which which WDT cord-005146-o3roa7br 192 27 include include VBP cord-005146-o3roa7br 192 28 ( ( -LRB- cord-005146-o3roa7br 192 29 1 1 CD cord-005146-o3roa7br 192 30 ) ) -RRB- cord-005146-o3roa7br 192 31 breakdown breakdown NN cord-005146-o3roa7br 192 32 of of IN cord-005146-o3roa7br 192 33 the the DT cord-005146-o3roa7br 192 34 GLM glm NN cord-005146-o3roa7br 192 35 , , , cord-005146-o3roa7br 192 36 ( ( -LRB- cord-005146-o3roa7br 192 37 2 2 LS cord-005146-o3roa7br 192 38 ) ) -RRB- cord-005146-o3roa7br 192 39 absence absence NN cord-005146-o3roa7br 192 40 of of IN cord-005146-o3roa7br 192 41 astrocytes astrocyte NNS cord-005146-o3roa7br 192 42 , , , cord-005146-o3roa7br 192 43 and and CC cord-005146-o3roa7br 192 44 ( ( -LRB- cord-005146-o3roa7br 192 45 3 3 LS cord-005146-o3roa7br 192 46 ) ) -RRB- cord-005146-o3roa7br 192 47 presence presence NN cord-005146-o3roa7br 192 48 of of IN cord-005146-o3roa7br 192 49 denuded denuded JJ cord-005146-o3roa7br 192 50 axons axon NNS cord-005146-o3roa7br 192 51 ( ( -LRB- cord-005146-o3roa7br 192 52 Blakemore Blakemore NNP cord-005146-o3roa7br 192 53 , , , cord-005146-o3roa7br 192 54 1983 1983 CD cord-005146-o3roa7br 192 55 ; ; : cord-005146-o3roa7br 192 56 Sims Sims NNP cord-005146-o3roa7br 192 57 & & CC cord-005146-o3roa7br 192 58 Gilmore Gilmore NNP cord-005146-o3roa7br 192 59 , , , cord-005146-o3roa7br 192 60 1983 1983 CD cord-005146-o3roa7br 192 61 ; ; : cord-005146-o3roa7br 192 62 Harrison Harrison NNP cord-005146-o3roa7br 192 63 , , , cord-005146-o3roa7br 192 64 1985 1985 CD cord-005146-o3roa7br 192 65 ; ; : cord-005146-o3roa7br 192 66 Gilmore Gilmore NNP cord-005146-o3roa7br 192 67 & & CC cord-005146-o3roa7br 192 68 Sims Sims NNP cord-005146-o3roa7br 192 69 , , , cord-005146-o3roa7br 192 70 1986 1986 CD cord-005146-o3roa7br 192 71 ) ) -RRB- cord-005146-o3roa7br 192 72 . . . cord-005146-o3roa7br 193 1 As as IN cord-005146-o3roa7br 193 2 described describe VBN cord-005146-o3roa7br 193 3 by by IN cord-005146-o3roa7br 193 4 previous previous JJ cord-005146-o3roa7br 193 5 authors author NNS cord-005146-o3roa7br 193 6 ( ( -LRB- cord-005146-o3roa7br 193 7 Blakemore Blakemore NNP cord-005146-o3roa7br 193 8 , , , cord-005146-o3roa7br 193 9 1983 1983 CD cord-005146-o3roa7br 193 10 ; ; : cord-005146-o3roa7br 193 11 Sims Sims NNP cord-005146-o3roa7br 193 12 & & CC cord-005146-o3roa7br 193 13 Gilmore Gilmore NNP cord-005146-o3roa7br 193 14 1983 1983 CD cord-005146-o3roa7br 193 15 ; ; : cord-005146-o3roa7br 193 16 Harrison Harrison NNP cord-005146-o3roa7br 193 17 , , , cord-005146-o3roa7br 193 18 1985 1985 CD cord-005146-o3roa7br 193 19 ) ) -RRB- cord-005146-o3roa7br 193 20 , , , cord-005146-o3roa7br 193 21 the the DT cord-005146-o3roa7br 193 22 breakdown breakdown NN cord-005146-o3roa7br 193 23 of of IN cord-005146-o3roa7br 193 24 the the DT cord-005146-o3roa7br 193 25 subpial subpial JJ cord-005146-o3roa7br 193 26 and and CC cord-005146-o3roa7br 193 27 perivascular perivascular NNP cord-005146-o3roa7br 193 28 GLM GLM NNP cord-005146-o3roa7br 193 29 might may MD cord-005146-o3roa7br 193 30 be be VB cord-005146-o3roa7br 193 31 the the DT cord-005146-o3roa7br 193 32 most most RBS cord-005146-o3roa7br 193 33 critical critical JJ cord-005146-o3roa7br 193 34 factor factor NN cord-005146-o3roa7br 193 35 for for IN cord-005146-o3roa7br 193 36 the the DT cord-005146-o3roa7br 193 37 appearance appearance NN cord-005146-o3roa7br 193 38 of of IN cord-005146-o3roa7br 193 39 Schwann Schwann NNP cord-005146-o3roa7br 193 40 cells cell NNS cord-005146-o3roa7br 193 41 . . . cord-005146-o3roa7br 194 1 Thus thus RB cord-005146-o3roa7br 194 2 in in IN cord-005146-o3roa7br 194 3 Cuprizone Cuprizone NNP cord-005146-o3roa7br 194 4 ( ( -LRB- cord-005146-o3roa7br 194 5 Ludwin Ludwin NNP cord-005146-o3roa7br 194 6 , , , cord-005146-o3roa7br 194 7 1978 1978 CD cord-005146-o3roa7br 194 8 ) ) -RRB- cord-005146-o3roa7br 194 9 and and CC cord-005146-o3roa7br 194 10 ordinary ordinary JJ cord-005146-o3roa7br 194 11 EAE EAE NNP cord-005146-o3roa7br 194 12 ( ( -LRB- cord-005146-o3roa7br 194 13 Lampert Lampert NNP cord-005146-o3roa7br 194 14 , , , cord-005146-o3roa7br 194 15 1965 1965 CD cord-005146-o3roa7br 194 16 ) ) -RRB- cord-005146-o3roa7br 194 17 injuries injury NNS cord-005146-o3roa7br 194 18 in in IN cord-005146-o3roa7br 194 19 which which WDT cord-005146-o3roa7br 194 20 the the DT cord-005146-o3roa7br 194 21 GLM GLM NNP cord-005146-o3roa7br 194 22 is be VBZ cord-005146-o3roa7br 194 23 retained retain VBN cord-005146-o3roa7br 194 24 intact intact JJ cord-005146-o3roa7br 194 25 , , , cord-005146-o3roa7br 194 26 few few JJ cord-005146-o3roa7br 194 27 Schwann Schwann NNP cord-005146-o3roa7br 194 28 cells cell NNS cord-005146-o3roa7br 194 29 appear appear VBP cord-005146-o3roa7br 194 30 in in IN cord-005146-o3roa7br 194 31 the the DT cord-005146-o3roa7br 194 32 lesion lesion NN cord-005146-o3roa7br 194 33 . . . cord-005146-o3roa7br 195 1 Harrison Harrison NNP cord-005146-o3roa7br 195 2 ( ( -LRB- cord-005146-o3roa7br 195 3 1985 1985 CD cord-005146-o3roa7br 195 4 ) ) -RRB- cord-005146-o3roa7br 195 5 thinks think VBZ cord-005146-o3roa7br 195 6 that that IN cord-005146-o3roa7br 195 7 Schwann Schwann NNP cord-005146-o3roa7br 195 8 cells cell NNS cord-005146-o3roa7br 195 9 invade invade VBP cord-005146-o3roa7br 195 10 the the DT cord-005146-o3roa7br 195 11 CNS CNS NNP cord-005146-o3roa7br 195 12 tissue tissue NN cord-005146-o3roa7br 195 13 through through IN cord-005146-o3roa7br 195 14 damaged damage VBN cord-005146-o3roa7br 195 15 GLM glm NN cord-005146-o3roa7br 195 16 at at IN cord-005146-o3roa7br 195 17 the the DT cord-005146-o3roa7br 195 18 perivascular perivascular JJ cord-005146-o3roa7br 195 19 and and CC cord-005146-o3roa7br 195 20 subpial subpial JJ cord-005146-o3roa7br 195 21 surfaces surface NNS cord-005146-o3roa7br 195 22 . . . cord-005146-o3roa7br 196 1 Astrocytes Astrocytes NNP cord-005146-o3roa7br 196 2 therefore therefore RB cord-005146-o3roa7br 196 3 seem seem VBP cord-005146-o3roa7br 196 4 to to TO cord-005146-o3roa7br 196 5 block block VB cord-005146-o3roa7br 196 6 the the DT cord-005146-o3roa7br 196 7 invasion invasion NN cord-005146-o3roa7br 196 8 of of IN cord-005146-o3roa7br 196 9 Schwann Schwann NNP cord-005146-o3roa7br 196 10 cells cell NNS cord-005146-o3roa7br 196 11 . . . cord-005146-o3roa7br 197 1 No no DT cord-005146-o3roa7br 197 2 astrocytes astrocyte NNS cord-005146-o3roa7br 197 3 were be VBD cord-005146-o3roa7br 197 4 found find VBN cord-005146-o3roa7br 197 5 in in IN cord-005146-o3roa7br 197 6 CNS CNS NNP cord-005146-o3roa7br 197 7 lesions lesion NNS cord-005146-o3roa7br 197 8 where where WRB cord-005146-o3roa7br 197 9 axons axon NNS cord-005146-o3roa7br 197 10 were be VBD cord-005146-o3roa7br 197 11 exclusively exclusively RB cord-005146-o3roa7br 197 12 myelinated myelinate VBN cord-005146-o3roa7br 197 13 by by IN cord-005146-o3roa7br 197 14 Schwann Schwann NNP cord-005146-o3roa7br 197 15 cells cell NNS cord-005146-o3roa7br 197 16 ( ( -LRB- cord-005146-o3roa7br 197 17 Hammang Hammang NNP cord-005146-o3roa7br 197 18 et et FW cord-005146-o3roa7br 197 19 al al NNP cord-005146-o3roa7br 197 20 . . NNP cord-005146-o3roa7br 197 21 , , , cord-005146-o3roa7br 197 22 1986 1986 CD cord-005146-o3roa7br 197 23 ) ) -RRB- cord-005146-o3roa7br 197 24 . . . cord-005146-o3roa7br 198 1 In in IN cord-005146-o3roa7br 198 2 contrast contrast NN cord-005146-o3roa7br 198 3 , , , cord-005146-o3roa7br 198 4 Schwann Schwann NNP cord-005146-o3roa7br 198 5 cells cell NNS cord-005146-o3roa7br 198 6 are be VBP cord-005146-o3roa7br 198 7 rarely rarely RB cord-005146-o3roa7br 198 8 seen see VBN cord-005146-o3roa7br 198 9 at at IN cord-005146-o3roa7br 198 10 the the DT cord-005146-o3roa7br 198 11 sites site NNS cord-005146-o3roa7br 198 12 where where WRB cord-005146-o3roa7br 198 13 astrocyte astrocyte NNP cord-005146-o3roa7br 198 14 processes process NNS cord-005146-o3roa7br 198 15 have have VBP cord-005146-o3roa7br 198 16 proliferated proliferate VBN cord-005146-o3roa7br 198 17 throughout throughout IN cord-005146-o3roa7br 198 18 the the DT cord-005146-o3roa7br 198 19 CNS CNS NNP cord-005146-o3roa7br 198 20 lesions lesion NNS cord-005146-o3roa7br 198 21 as as IN cord-005146-o3roa7br 198 22 a a DT cord-005146-o3roa7br 198 23 result result NN cord-005146-o3roa7br 198 24 of of IN cord-005146-o3roa7br 198 25 LPC LPC NNP cord-005146-o3roa7br 198 26 and and CC cord-005146-o3roa7br 198 27 6-AN 6-an CD cord-005146-o3roa7br 198 28 treatment treatment NN cord-005146-o3roa7br 198 29 , , , cord-005146-o3roa7br 198 30 and and CC cord-005146-o3roa7br 198 31 JHM JHM NNP cord-005146-o3roa7br 198 32 virus virus NN cord-005146-o3roa7br 198 33 and and CC cord-005146-o3roa7br 198 34 TME TME NNP cord-005146-o3roa7br 198 35 virus virus NN cord-005146-o3roa7br 198 36 infection infection NN cord-005146-o3roa7br 198 37 ( ( -LRB- cord-005146-o3roa7br 198 38 Blakemore Blakemore NNP cord-005146-o3roa7br 198 39 , , , cord-005146-o3roa7br 198 40 1975 1975 CD cord-005146-o3roa7br 198 41 ( ( -LRB- cord-005146-o3roa7br 198 42 Blakemore Blakemore NNP cord-005146-o3roa7br 198 43 , , , cord-005146-o3roa7br 198 44 , , , cord-005146-o3roa7br 198 45 1976 1976 CD cord-005146-o3roa7br 198 46 Nagashima Nagashima NNP cord-005146-o3roa7br 198 47 et et NNP cord-005146-o3roa7br 198 48 al al NNP cord-005146-o3roa7br 198 49 . . NNP cord-005146-o3roa7br 198 50 , , , cord-005146-o3roa7br 198 51 1979 1979 CD cord-005146-o3roa7br 198 52 ; ; : cord-005146-o3roa7br 198 53 Dal Dal NNP cord-005146-o3roa7br 198 54 Canto Canto NNP cord-005146-o3roa7br 198 55 & & CC cord-005146-o3roa7br 198 56 Lipton Lipton NNP cord-005146-o3roa7br 198 57 , , , cord-005146-o3roa7br 198 58 1980 1980 CD cord-005146-o3roa7br 198 59 ) ) -RRB- cord-005146-o3roa7br 198 60 , , , cord-005146-o3roa7br 198 61 as as RB cord-005146-o3roa7br 198 62 well well RB cord-005146-o3roa7br 198 63 as as IN cord-005146-o3roa7br 198 64 Schwann Schwann NNP cord-005146-o3roa7br 198 65 cell cell NN cord-005146-o3roa7br 198 66 implantation implantation NN cord-005146-o3roa7br 198 67 into into IN cord-005146-o3roa7br 198 68 normal normal JJ cord-005146-o3roa7br 198 69 nervous nervous JJ cord-005146-o3roa7br 198 70 tissue tissue NN cord-005146-o3roa7br 199 1 ( ( -LRB- cord-005146-o3roa7br 199 2 Blakemore Blakemore NNP cord-005146-o3roa7br 199 3 et et NNP cord-005146-o3roa7br 199 4 al al NNP cord-005146-o3roa7br 199 5 . . NNP cord-005146-o3roa7br 199 6 , , , cord-005146-o3roa7br 199 7 1986 1986 CD cord-005146-o3roa7br 199 8 ) ) -RRB- cord-005146-o3roa7br 199 9 . . . cord-005146-o3roa7br 200 1 Denuded denuded JJ cord-005146-o3roa7br 200 2 axons axon NNS cord-005146-o3roa7br 200 3 seem seem VBP cord-005146-o3roa7br 200 4 necessary necessary JJ cord-005146-o3roa7br 200 5 for for IN cord-005146-o3roa7br 200 6 Schwann Schwann NNP cord-005146-o3roa7br 200 7 cells cell NNS cord-005146-o3roa7br 200 8 to to TO cord-005146-o3roa7br 200 9 invade invade VB cord-005146-o3roa7br 200 10 the the DT cord-005146-o3roa7br 200 11 CNS CNS NNP cord-005146-o3roa7br 200 12 and and CC cord-005146-o3roa7br 200 13 proliferate proliferate VB cord-005146-o3roa7br 200 14 . . . cord-005146-o3roa7br 201 1 It -PRON- PRP cord-005146-o3roa7br 201 2 was be VBD cord-005146-o3roa7br 201 3 reported report VBN cord-005146-o3roa7br 201 4 that that IN cord-005146-o3roa7br 201 5 naked naked JJ cord-005146-o3roa7br 201 6 axons axon NNS cord-005146-o3roa7br 201 7 have have VBP cord-005146-o3roa7br 201 8 a a DT cord-005146-o3roa7br 201 9 mitogenic mitogenic JJ cord-005146-o3roa7br 201 10 influence influence NN cord-005146-o3roa7br 201 11 on on IN cord-005146-o3roa7br 201 12 Schwann Schwann NNP cord-005146-o3roa7br 201 13 cells cell NNS cord-005146-o3roa7br 201 14 in in IN cord-005146-o3roa7br 201 15 vitro vitro FW cord-005146-o3roa7br 201 16 ( ( -LRB- cord-005146-o3roa7br 201 17 Wood Wood NNP cord-005146-o3roa7br 201 18 & & CC cord-005146-o3roa7br 201 19 Bunge Bunge NNP cord-005146-o3roa7br 201 20 , , , cord-005146-o3roa7br 201 21 1975 1975 CD cord-005146-o3roa7br 201 22 ) ) -RRB- cord-005146-o3roa7br 201 23 . . . cord-005146-o3roa7br 202 1 Harrison Harrison NNP cord-005146-o3roa7br 202 2 ( ( -LRB- cord-005146-o3roa7br 202 3 1987 1987 CD cord-005146-o3roa7br 202 4 ) ) -RRB- cord-005146-o3roa7br 203 1 Fig Fig NNP cord-005146-o3roa7br 203 2 . . . cord-005146-o3roa7br 204 1 10 10 CD cord-005146-o3roa7br 204 2 . . . cord-005146-o3roa7br 205 1 One one CD cord-005146-o3roa7br 205 2 month month NN cord-005146-o3roa7br 205 3 after after IN cord-005146-o3roa7br 205 4 treatment treatment NN cord-005146-o3roa7br 205 5 . . . cord-005146-o3roa7br 206 1 This this DT cord-005146-o3roa7br 206 2 micrograph micrograph NN cord-005146-o3roa7br 206 3 was be VBD cord-005146-o3roa7br 206 4 taken take VBN cord-005146-o3roa7br 206 5 at at IN cord-005146-o3roa7br 206 6 the the DT cord-005146-o3roa7br 206 7 transitional transitional JJ cord-005146-o3roa7br 206 8 zone zone NN cord-005146-o3roa7br 206 9 between between IN cord-005146-o3roa7br 206 10 the the DT cord-005146-o3roa7br 206 11 Schwann Schwann NNP cord-005146-o3roa7br 206 12 cell cell NN cord-005146-o3roa7br 206 13 - - HYPH cord-005146-o3roa7br 206 14 myelinated myelinated JJ cord-005146-o3roa7br 206 15 area area NN cord-005146-o3roa7br 206 16 and and CC cord-005146-o3roa7br 206 17 the the DT cord-005146-o3roa7br 206 18 oligodendrocyte oligodendrocyte RB cord-005146-o3roa7br 206 19 - - HYPH cord-005146-o3roa7br 206 20 myelinated myelinated JJ cord-005146-o3roa7br 206 21 area area NN cord-005146-o3roa7br 206 22 . . . cord-005146-o3roa7br 207 1 Oligodendrocyte Oligodendrocyte NNP cord-005146-o3roa7br 207 2 - - HYPH cord-005146-o3roa7br 207 3 myelinated myelinate VBN cord-005146-o3roa7br 207 4 axons axon NNS cord-005146-o3roa7br 207 5 ( ( -LRB- cord-005146-o3roa7br 207 6 Ax Ax NNP cord-005146-o3roa7br 207 7 ) ) -RRB- cord-005146-o3roa7br 207 8 and and CC cord-005146-o3roa7br 207 9 oligodendrocyte oligodendrocyte NNP cord-005146-o3roa7br 207 10 cytoplasm cytoplasm NNP cord-005146-o3roa7br 207 11 ( ( -LRB- cord-005146-o3roa7br 207 12 O1 o1 NN cord-005146-o3roa7br 207 13 ) ) -RRB- cord-005146-o3roa7br 208 1 both both DT cord-005146-o3roa7br 208 2 directly directly RB cord-005146-o3roa7br 208 3 abut abut VBP cord-005146-o3roa7br 208 4 ( ( -LRB- cord-005146-o3roa7br 208 5 arrows arrow NNS cord-005146-o3roa7br 208 6 ) ) -RRB- cord-005146-o3roa7br 208 7 on on IN cord-005146-o3roa7br 208 8 the the DT cord-005146-o3roa7br 208 9 basal basal NN cord-005146-o3roa7br 208 10 laminae laminae NN cord-005146-o3roa7br 208 11 of of IN cord-005146-o3roa7br 208 12 the the DT cord-005146-o3roa7br 208 13 Schwann Schwann NNP cord-005146-o3roa7br 208 14 cells cell NNS cord-005146-o3roa7br 208 15 ( ( -LRB- cord-005146-o3roa7br 208 16 S s NN cord-005146-o3roa7br 208 17 ) ) -RRB- cord-005146-o3roa7br 208 18 without without IN cord-005146-o3roa7br 208 19 any any DT cord-005146-o3roa7br 208 20 intervening intervene VBG cord-005146-o3roa7br 208 21 astrocyte astrocyte NNP cord-005146-o3roa7br 208 22 processes process NNS cord-005146-o3roa7br 208 23 . . . cord-005146-o3roa7br 209 1 x x LS cord-005146-o3roa7br 209 2 23 23 CD cord-005146-o3roa7br 209 3 000 000 CD cord-005146-o3roa7br 209 4 . . . cord-005146-o3roa7br 210 1 demonstrated demonstrate VBN cord-005146-o3roa7br 210 2 by by IN cord-005146-o3roa7br 210 3 autoradiography autoradiography NNP cord-005146-o3roa7br 210 4 that that IN cord-005146-o3roa7br 210 5 Schwann Schwann NNP cord-005146-o3roa7br 210 6 cell cell NN cord-005146-o3roa7br 210 7 division division NN cord-005146-o3roa7br 210 8 is be VBZ cord-005146-o3roa7br 210 9 only only RB cord-005146-o3roa7br 210 10 initiated initiate VBN cord-005146-o3roa7br 210 11 and and CC cord-005146-o3roa7br 210 12 promoted promote VBN cord-005146-o3roa7br 210 13 by by IN cord-005146-o3roa7br 210 14 direct direct JJ cord-005146-o3roa7br 210 15 contact contact NN cord-005146-o3roa7br 210 16 with with IN cord-005146-o3roa7br 210 17 denuded denuded JJ cord-005146-o3roa7br 210 18 axons axon NNS cord-005146-o3roa7br 210 19 . . . cord-005146-o3roa7br 211 1 It -PRON- PRP cord-005146-o3roa7br 211 2 has have VBZ cord-005146-o3roa7br 211 3 also also RB cord-005146-o3roa7br 211 4 been be VBN cord-005146-o3roa7br 211 5 suggested suggest VBN cord-005146-o3roa7br 211 6 that that IN cord-005146-o3roa7br 211 7 ensheathment ensheathment NN cord-005146-o3roa7br 211 8 of of IN cord-005146-o3roa7br 211 9 denuded denuded JJ cord-005146-o3roa7br 211 10 axons axon NNS cord-005146-o3roa7br 211 11 by by IN cord-005146-o3roa7br 211 12 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 211 13 or or CC cord-005146-o3roa7br 211 14 astrocytes astrocyte NNS cord-005146-o3roa7br 211 15 eliminated eliminate VBD cord-005146-o3roa7br 211 16 mitogenic mitogenic JJ cord-005146-o3roa7br 211 17 influences influence NNS cord-005146-o3roa7br 211 18 of of IN cord-005146-o3roa7br 211 19 naked naked JJ cord-005146-o3roa7br 211 20 axons axon NNS cord-005146-o3roa7br 211 21 on on IN cord-005146-o3roa7br 211 22 Schwann Schwann NNP cord-005146-o3roa7br 211 23 cells cell NNS cord-005146-o3roa7br 211 24 ( ( -LRB- cord-005146-o3roa7br 211 25 Sims Sims NNP cord-005146-o3roa7br 211 26 & & CC cord-005146-o3roa7br 211 27 Gilmore Gilmore NNP cord-005146-o3roa7br 211 28 , , , cord-005146-o3roa7br 211 29 1983 1983 CD cord-005146-o3roa7br 211 30 ) ) -RRB- cord-005146-o3roa7br 211 31 . . . cord-005146-o3roa7br 212 1 Where where WRB cord-005146-o3roa7br 212 2 are be VBP cord-005146-o3roa7br 212 3 the the DT cord-005146-o3roa7br 212 4 sources source NNS cord-005146-o3roa7br 212 5 of of IN cord-005146-o3roa7br 212 6 ectopic ectopic JJ cord-005146-o3roa7br 212 7 Schwann Schwann NNP cord-005146-o3roa7br 212 8 cells cell NNS cord-005146-o3roa7br 212 9 ? ? . cord-005146-o3roa7br 213 1 Since since IN cord-005146-o3roa7br 213 2 many many JJ cord-005146-o3roa7br 213 3 ectopic ectopic JJ cord-005146-o3roa7br 213 4 Schwann Schwann NNP cord-005146-o3roa7br 213 5 cells cell NNS cord-005146-o3roa7br 213 6 are be VBP cord-005146-o3roa7br 213 7 found find VBN cord-005146-o3roa7br 213 8 near near IN cord-005146-o3roa7br 213 9 the the DT cord-005146-o3roa7br 213 10 nerve nerve NN cord-005146-o3roa7br 213 11 root root NN cord-005146-o3roa7br 213 12 entry entry NN cord-005146-o3roa7br 213 13 , , , cord-005146-o3roa7br 213 14 it -PRON- PRP cord-005146-o3roa7br 213 15 is be VBZ cord-005146-o3roa7br 213 16 supposed suppose VBN cord-005146-o3roa7br 213 17 that that IN cord-005146-o3roa7br 213 18 Schwann Schwann NNP cord-005146-o3roa7br 213 19 cells cell NNS cord-005146-o3roa7br 213 20 in in IN cord-005146-o3roa7br 213 21 the the DT cord-005146-o3roa7br 213 22 root root NN cord-005146-o3roa7br 213 23 could could MD cord-005146-o3roa7br 213 24 move move VB cord-005146-o3roa7br 213 25 along along IN cord-005146-o3roa7br 213 26 the the DT cord-005146-o3roa7br 213 27 denuded denuded JJ cord-005146-o3roa7br 213 28 axons axon NNS cord-005146-o3roa7br 213 29 into into IN cord-005146-o3roa7br 213 30 the the DT cord-005146-o3roa7br 213 31 injured injure VBN cord-005146-o3roa7br 213 32 CNS CNS NNP cord-005146-o3roa7br 213 33 ( ( -LRB- cord-005146-o3roa7br 213 34 Gilmore Gilmore NNP cord-005146-o3roa7br 213 35 & & CC cord-005146-o3roa7br 213 36 Duncan Duncan NNP cord-005146-o3roa7br 213 37 , , , cord-005146-o3roa7br 213 38 1968 1968 CD cord-005146-o3roa7br 213 39 ) ) -RRB- cord-005146-o3roa7br 213 40 . . . cord-005146-o3roa7br 214 1 However however RB cord-005146-o3roa7br 214 2 , , , cord-005146-o3roa7br 214 3 even even RB cord-005146-o3roa7br 214 4 when when WRB cord-005146-o3roa7br 214 5 the the DT cord-005146-o3roa7br 214 6 roots root NNS cord-005146-o3roa7br 214 7 and and CC cord-005146-o3roa7br 214 8 their -PRON- PRP$ cord-005146-o3roa7br 214 9 entry entry NN cord-005146-o3roa7br 214 10 zones zone NNS cord-005146-o3roa7br 214 11 are be VBP cord-005146-o3roa7br 214 12 preserved preserve VBN cord-005146-o3roa7br 214 13 undamaged undamaged JJ cord-005146-o3roa7br 214 14 , , , cord-005146-o3roa7br 214 15 many many JJ cord-005146-o3roa7br 214 16 Schwann Schwann NNP cord-005146-o3roa7br 214 17 cells cell NNS cord-005146-o3roa7br 214 18 have have VBP cord-005146-o3roa7br 214 19 been be VBN cord-005146-o3roa7br 214 20 seen see VBN cord-005146-o3roa7br 214 21 in in IN cord-005146-o3roa7br 214 22 the the DT cord-005146-o3roa7br 214 23 midline midline NN cord-005146-o3roa7br 214 24 of of IN cord-005146-o3roa7br 214 25 the the DT cord-005146-o3roa7br 214 26 dorsal dorsal JJ cord-005146-o3roa7br 214 27 funiculus funiculu NNS cord-005146-o3roa7br 214 28 , , , cord-005146-o3roa7br 214 29 far far RB cord-005146-o3roa7br 214 30 from from IN cord-005146-o3roa7br 214 31 the the DT cord-005146-o3roa7br 214 32 root root NN cord-005146-o3roa7br 214 33 entry entry NN cord-005146-o3roa7br 214 34 ( ( -LRB- cord-005146-o3roa7br 214 35 Gilmore Gilmore NNP cord-005146-o3roa7br 214 36 & & CC cord-005146-o3roa7br 214 37 Sims Sims NNP cord-005146-o3roa7br 214 38 , , , cord-005146-o3roa7br 214 39 1986 1986 CD cord-005146-o3roa7br 214 40 ) ) -RRB- cord-005146-o3roa7br 214 41 . . . cord-005146-o3roa7br 215 1 On on IN cord-005146-o3roa7br 215 2 the the DT cord-005146-o3roa7br 215 3 other other JJ cord-005146-o3roa7br 215 4 hand hand NN cord-005146-o3roa7br 215 5 , , , cord-005146-o3roa7br 215 6 Schwann Schwann NNP cord-005146-o3roa7br 215 7 cells cell NNS cord-005146-o3roa7br 215 8 of of IN cord-005146-o3roa7br 215 9 the the DT cord-005146-o3roa7br 215 10 perivascular perivascular JJ cord-005146-o3roa7br 215 11 autonomic autonomic JJ cord-005146-o3roa7br 215 12 nerves nerve NNS cord-005146-o3roa7br 215 13 ( ( -LRB- cord-005146-o3roa7br 215 14 Ghatak Ghatak NNP cord-005146-o3roa7br 215 15 et et NNP cord-005146-o3roa7br 215 16 aI. ai. NN cord-005146-o3roa7br 215 17 , , , cord-005146-o3roa7br 215 18 1973 1973 CD cord-005146-o3roa7br 215 19 ) ) -RRB- cord-005146-o3roa7br 215 20 and and CC cord-005146-o3roa7br 215 21 of of IN cord-005146-o3roa7br 215 22 small small JJ cord-005146-o3roa7br 215 23 nerves nerve NNS cord-005146-o3roa7br 215 24 located locate VBN cord-005146-o3roa7br 215 25 in in IN cord-005146-o3roa7br 215 26 a a DT cord-005146-o3roa7br 215 27 pial pial JJ cord-005146-o3roa7br 215 28 layer layer NN cord-005146-o3roa7br 215 29 ( ( -LRB- cord-005146-o3roa7br 215 30 Blakemore Blakemore NNP cord-005146-o3roa7br 215 31 , , , cord-005146-o3roa7br 215 32 1983 1983 CD cord-005146-o3roa7br 215 33 ) ) -RRB- cord-005146-o3roa7br 215 34 could could MD cord-005146-o3roa7br 215 35 proliferate proliferate VB cord-005146-o3roa7br 215 36 and and CC cord-005146-o3roa7br 215 37 migrate migrate VB cord-005146-o3roa7br 215 38 into into IN cord-005146-o3roa7br 215 39 the the DT cord-005146-o3roa7br 215 40 lesion lesion NN cord-005146-o3roa7br 215 41 . . . cord-005146-o3roa7br 216 1 Though though IN cord-005146-o3roa7br 216 2 the the DT cord-005146-o3roa7br 216 3 sources source NNS cord-005146-o3roa7br 216 4 of of IN cord-005146-o3roa7br 216 5 ectopic ectopic JJ cord-005146-o3roa7br 216 6 Schwann Schwann NNP cord-005146-o3roa7br 216 7 cells cell NNS cord-005146-o3roa7br 216 8 could could MD cord-005146-o3roa7br 216 9 not not RB cord-005146-o3roa7br 216 10 be be VB cord-005146-o3roa7br 216 11 clearly clearly RB cord-005146-o3roa7br 216 12 identified identify VBN cord-005146-o3roa7br 216 13 , , , cord-005146-o3roa7br 216 14 the the DT cord-005146-o3roa7br 216 15 present present JJ cord-005146-o3roa7br 216 16 study study NN cord-005146-o3roa7br 216 17 indicates indicate VBZ cord-005146-o3roa7br 216 18 that that IN cord-005146-o3roa7br 216 19 damage damage NN cord-005146-o3roa7br 216 20 to to IN cord-005146-o3roa7br 216 21 glial glial JJ cord-005146-o3roa7br 216 22 cells cell NNS cord-005146-o3roa7br 216 23 as as RB cord-005146-o3roa7br 216 24 well well RB cord-005146-o3roa7br 216 25 as as IN cord-005146-o3roa7br 216 26 the the DT cord-005146-o3roa7br 216 27 GLM GLM NNP cord-005146-o3roa7br 216 28 at at IN cord-005146-o3roa7br 216 29 the the DT cord-005146-o3roa7br 216 30 pial pial JJ cord-005146-o3roa7br 216 31 and and CC cord-005146-o3roa7br 216 32 perivascular perivascular JJ cord-005146-o3roa7br 216 33 surfaces surface NNS cord-005146-o3roa7br 216 34 might may MD cord-005146-o3roa7br 216 35 be be VB cord-005146-o3roa7br 216 36 the the DT cord-005146-o3roa7br 216 37 most most RBS cord-005146-o3roa7br 216 38 important important JJ cord-005146-o3roa7br 216 39 prerequisite prerequisite NN cord-005146-o3roa7br 216 40 ( ( -LRB- cord-005146-o3roa7br 216 41 Blakemore Blakemore NNP cord-005146-o3roa7br 216 42 et et NNP cord-005146-o3roa7br 216 43 aI. ai. NN cord-005146-o3roa7br 216 44 , , , cord-005146-o3roa7br 216 45 1986 1986 CD cord-005146-o3roa7br 216 46 ) ) -RRB- cord-005146-o3roa7br 216 47 . . . cord-005146-o3roa7br 217 1 Oligodendrocytes Oligodendrocytes NNP cord-005146-o3roa7br 217 2 remyelinate remyelinate NN cord-005146-o3roa7br 217 3 denuded denude VBD cord-005146-o3roa7br 217 4 axons axon NNS cord-005146-o3roa7br 217 5 after after IN cord-005146-o3roa7br 217 6 Cuprizone Cuprizone NNP cord-005146-o3roa7br 217 7 intoxication intoxication NN cord-005146-o3roa7br 217 8 ( ( -LRB- cord-005146-o3roa7br 217 9 Ludwin Ludwin NNP cord-005146-o3roa7br 217 10 , , , cord-005146-o3roa7br 217 11 1987 1987 CD cord-005146-o3roa7br 218 1 ( ( -LRB- cord-005146-o3roa7br 218 2 Ludwin Ludwin NNP cord-005146-o3roa7br 218 3 , , , cord-005146-o3roa7br 218 4 , , , cord-005146-o3roa7br 218 5 1988 1988 CD cord-005146-o3roa7br 218 6 and and CC cord-005146-o3roa7br 218 7 other other JJ cord-005146-o3roa7br 218 8 CNS CNS NNP cord-005146-o3roa7br 218 9 lesions lesion NNS cord-005146-o3roa7br 218 10 including include VBG cord-005146-o3roa7br 218 11 chronic chronic JJ cord-005146-o3roa7br 218 12 relapsing relapse VBG cord-005146-o3roa7br 218 13 EAE EAE NNP cord-005146-o3roa7br 218 14 ( ( -LRB- cord-005146-o3roa7br 218 15 Raine Raine NNP cord-005146-o3roa7br 218 16 & & CC cord-005146-o3roa7br 218 17 Traugott Traugott NNP cord-005146-o3roa7br 218 18 , , , cord-005146-o3roa7br 218 19 1985 1985 CD cord-005146-o3roa7br 218 20 ) ) -RRB- cord-005146-o3roa7br 218 21 and and CC cord-005146-o3roa7br 218 22 TME TME NNP cord-005146-o3roa7br 218 23 virus virus NN cord-005146-o3roa7br 218 24 infection infection NN cord-005146-o3roa7br 218 25 ( ( -LRB- cord-005146-o3roa7br 218 26 Dal Dal NNP cord-005146-o3roa7br 218 27 Canto Canto NNP cord-005146-o3roa7br 218 28 & & CC cord-005146-o3roa7br 218 29 Barbano Barbano NNP cord-005146-o3roa7br 218 30 , , , cord-005146-o3roa7br 218 31 1984 1984 CD cord-005146-o3roa7br 218 32 ) ) -RRB- cord-005146-o3roa7br 218 33 . . . cord-005146-o3roa7br 219 1 In in IN cord-005146-o3roa7br 219 2 these these DT cord-005146-o3roa7br 219 3 studies study NNS cord-005146-o3roa7br 219 4 , , , cord-005146-o3roa7br 219 5 as as IN cord-005146-o3roa7br 219 6 in in IN cord-005146-o3roa7br 219 7 the the DT cord-005146-o3roa7br 219 8 present present JJ cord-005146-o3roa7br 219 9 study study NN cord-005146-o3roa7br 219 10 , , , cord-005146-o3roa7br 219 11 remyelination remyelination NN cord-005146-o3roa7br 219 12 by by IN cord-005146-o3roa7br 219 13 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 219 14 occurred occur VBD cord-005146-o3roa7br 219 15 in in IN cord-005146-o3roa7br 219 16 deep deep JJ cord-005146-o3roa7br 219 17 areas area NNS cord-005146-o3roa7br 219 18 of of IN cord-005146-o3roa7br 219 19 the the DT cord-005146-o3roa7br 219 20 lesion lesion NN cord-005146-o3roa7br 219 21 , , , cord-005146-o3roa7br 219 22 where where WRB cord-005146-o3roa7br 219 23 there there EX cord-005146-o3roa7br 219 24 might may MD cord-005146-o3roa7br 219 25 be be VB cord-005146-o3roa7br 219 26 no no DT cord-005146-o3roa7br 219 27 influence influence NN cord-005146-o3roa7br 219 28 of of IN cord-005146-o3roa7br 219 29 the the DT cord-005146-o3roa7br 219 30 damaged damage VBN cord-005146-o3roa7br 219 31 GLM GLM NNP cord-005146-o3roa7br 219 32 . . . cord-005146-o3roa7br 220 1 On on IN cord-005146-o3roa7br 220 2 the the DT cord-005146-o3roa7br 220 3 other other JJ cord-005146-o3roa7br 220 4 hand hand NN cord-005146-o3roa7br 220 5 , , , cord-005146-o3roa7br 220 6 there there EX cord-005146-o3roa7br 220 7 is be VBZ cord-005146-o3roa7br 220 8 evidence evidence NN cord-005146-o3roa7br 220 9 that that IN cord-005146-o3roa7br 220 10 astrocytes astrocyte NNS cord-005146-o3roa7br 220 11 can can MD cord-005146-o3roa7br 220 12 co co VB cord-005146-o3roa7br 220 13 - - VB cord-005146-o3roa7br 220 14 operate operate VB cord-005146-o3roa7br 220 15 to to IN cord-005146-o3roa7br 220 16 some some DT cord-005146-o3roa7br 220 17 extent extent NN cord-005146-o3roa7br 220 18 with with IN cord-005146-o3roa7br 220 19 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 220 20 in in IN cord-005146-o3roa7br 220 21 the the DT cord-005146-o3roa7br 220 22 facilitation facilitation NN cord-005146-o3roa7br 220 23 of of IN cord-005146-o3roa7br 220 24 myelination myelination NN cord-005146-o3roa7br 220 25 ( ( -LRB- cord-005146-o3roa7br 220 26 Blakemore Blakemore NNP cord-005146-o3roa7br 220 27 , , , cord-005146-o3roa7br 220 28 1975 1975 CD cord-005146-o3roa7br 220 29 ( ( -LRB- cord-005146-o3roa7br 220 30 Blakemore Blakemore NNP cord-005146-o3roa7br 220 31 , , , cord-005146-o3roa7br 220 32 , , , cord-005146-o3roa7br 220 33 1984 1984 CD cord-005146-o3roa7br 220 34 Fig Fig NNP cord-005146-o3roa7br 220 35 . . . cord-005146-o3roa7br 221 1 11 11 CD cord-005146-o3roa7br 221 2 . . . cord-005146-o3roa7br 222 1 One one CD cord-005146-o3roa7br 222 2 month month NN cord-005146-o3roa7br 222 3 after after IN cord-005146-o3roa7br 222 4 treatment treatment NN cord-005146-o3roa7br 222 5 . . . cord-005146-o3roa7br 223 1 This this DT cord-005146-o3roa7br 223 2 electron electron NN cord-005146-o3roa7br 223 3 micrograph micrograph NN cord-005146-o3roa7br 223 4 shows show VBZ cord-005146-o3roa7br 223 5 a a DT cord-005146-o3roa7br 223 6 longitudinal longitudinal JJ cord-005146-o3roa7br 223 7 section section NN cord-005146-o3roa7br 223 8 from from IN cord-005146-o3roa7br 223 9 the the DT cord-005146-o3roa7br 223 10 caudal caudal JJ cord-005146-o3roa7br 223 11 part part NN cord-005146-o3roa7br 223 12 of of IN cord-005146-o3roa7br 223 13 the the DT cord-005146-o3roa7br 223 14 lesion lesion NN cord-005146-o3roa7br 223 15 . . . cord-005146-o3roa7br 224 1 A a DT cord-005146-o3roa7br 224 2 myelin myelin NN cord-005146-o3roa7br 224 3 sheath sheath NN cord-005146-o3roa7br 224 4 newly newly RB cord-005146-o3roa7br 224 5 formed form VBN cord-005146-o3roa7br 224 6 by by IN cord-005146-o3roa7br 224 7 Schwann Schwann NNP cord-005146-o3roa7br 224 8 cells cell NNS cord-005146-o3roa7br 224 9 ( ( -LRB- cord-005146-o3roa7br 224 10 S s NN cord-005146-o3roa7br 224 11 ) ) -RRB- cord-005146-o3roa7br 224 12 makes make VBZ cord-005146-o3roa7br 224 13 a a DT cord-005146-o3roa7br 224 14 node node NN cord-005146-o3roa7br 224 15 of of IN cord-005146-o3roa7br 224 16 Ranvier Ranvier NNP cord-005146-o3roa7br 224 17 ( ( -LRB- cord-005146-o3roa7br 224 18 arrow arrow NN cord-005146-o3roa7br 224 19 ) ) -RRB- cord-005146-o3roa7br 224 20 at at IN cord-005146-o3roa7br 224 21 the the DT cord-005146-o3roa7br 224 22 junction junction NN cord-005146-o3roa7br 224 23 with with IN cord-005146-o3roa7br 224 24 a a DT cord-005146-o3roa7br 224 25 thick thick JJ cord-005146-o3roa7br 224 26 CNS CNS NNP cord-005146-o3roa7br 224 27 - - HYPH cord-005146-o3roa7br 224 28 type type NN cord-005146-o3roa7br 224 29 myelin myelin NN cord-005146-o3roa7br 224 30 sheath sheath NN cord-005146-o3roa7br 224 31 ( ( -LRB- cord-005146-o3roa7br 224 32 C C NNP cord-005146-o3roa7br 224 33 ) ) -RRB- cord-005146-o3roa7br 224 34 which which WDT cord-005146-o3roa7br 224 35 presumably presumably RB cord-005146-o3roa7br 224 36 survived survive VBD cord-005146-o3roa7br 224 37 the the DT cord-005146-o3roa7br 224 38 heat heat NN cord-005146-o3roa7br 224 39 treatment treatment NN cord-005146-o3roa7br 224 40 . . . cord-005146-o3roa7br 225 1 There there EX cord-005146-o3roa7br 225 2 are be VBP cord-005146-o3roa7br 225 3 two two CD cord-005146-o3roa7br 225 4 fibres fibre NNS cord-005146-o3roa7br 225 5 that that WDT cord-005146-o3roa7br 225 6 are be VBP cord-005146-o3roa7br 225 7 partly partly RB cord-005146-o3roa7br 225 8 myelinated myelinate VBN cord-005146-o3roa7br 225 9 by by IN cord-005146-o3roa7br 225 10 Schwann Schwann NNP cord-005146-o3roa7br 225 11 cells cell NNS cord-005146-o3roa7br 225 12 ( ( -LRB- cord-005146-o3roa7br 225 13 S s NN cord-005146-o3roa7br 225 14 ) ) -RRB- cord-005146-o3roa7br 225 15 and and CC cord-005146-o3roa7br 225 16 partly partly RB cord-005146-o3roa7br 225 17 by by IN cord-005146-o3roa7br 225 18 otigodendrocytes otigodendrocytes NNP cord-005146-o3roa7br 225 19 ( ( -LRB- cord-005146-o3roa7br 225 20 O1 O1 NNP cord-005146-o3roa7br 225 21 ) ) -RRB- cord-005146-o3roa7br 225 22 , , , cord-005146-o3roa7br 225 23 forming form VBG cord-005146-o3roa7br 225 24 new new JJ cord-005146-o3roa7br 225 25 nodes node NNS cord-005146-o3roa7br 225 26 of of IN cord-005146-o3roa7br 225 27 Ranvier Ranvier NNP cord-005146-o3roa7br 225 28 between between IN cord-005146-o3roa7br 225 29 them -PRON- PRP cord-005146-o3roa7br 225 30 ( ( -LRB- cord-005146-o3roa7br 225 31 arrowheads arrowhead NNS cord-005146-o3roa7br 225 32 ) ) -RRB- cord-005146-o3roa7br 225 33 . . . cord-005146-o3roa7br 226 1 x x LS cord-005146-o3roa7br 226 2 7600 7600 CD cord-005146-o3roa7br 226 3 . . . cord-005146-o3roa7br 227 1 Inset Inset NNP cord-005146-o3roa7br 227 2 : : : cord-005146-o3roa7br 227 3 a a DT cord-005146-o3roa7br 227 4 high high RB cord-005146-o3roa7br 227 5 - - HYPH cord-005146-o3roa7br 227 6 powered powered JJ cord-005146-o3roa7br 227 7 micrograpl~ micrograpl~ NN cord-005146-o3roa7br 227 8 showing show VBG cord-005146-o3roa7br 227 9 a a DT cord-005146-o3roa7br 227 10 similar similar JJ cord-005146-o3roa7br 227 11 node node NN cord-005146-o3roa7br 227 12 of of IN cord-005146-o3roa7br 227 13 Ranvier Ranvier NNP cord-005146-o3roa7br 227 14 taken take VBN cord-005146-o3roa7br 227 15 from from IN cord-005146-o3roa7br 227 16 other other JJ cord-005146-o3roa7br 227 17 section section NN cord-005146-o3roa7br 227 18 . . . cord-005146-o3roa7br 228 1 A a DT cord-005146-o3roa7br 228 2 lateral lateral JJ cord-005146-o3roa7br 228 3 loop loop NN cord-005146-o3roa7br 228 4 ( ( -LRB- cord-005146-o3roa7br 228 5 asterisk asterisk NN cord-005146-o3roa7br 228 6 ) ) -RRB- cord-005146-o3roa7br 228 7 of of IN cord-005146-o3roa7br 228 8 the the DT cord-005146-o3roa7br 228 9 oligodendrocyte oligodendrocyte NNP cord-005146-o3roa7br 228 10 is be VBZ cord-005146-o3roa7br 228 11 contiguous contiguous JJ cord-005146-o3roa7br 228 12 with with IN cord-005146-o3roa7br 228 13 a a DT cord-005146-o3roa7br 228 14 Schwann Schwann NNP cord-005146-o3roa7br 228 15 cell cell NN cord-005146-o3roa7br 228 16 process process NN cord-005146-o3roa7br 228 17 ( ( -LRB- cord-005146-o3roa7br 228 18 arrowhead arrowhead NNP cord-005146-o3roa7br 228 19 ) ) -RRB- cord-005146-o3roa7br 228 20 . . . cord-005146-o3roa7br 229 1 No no DT cord-005146-o3roa7br 229 2 astrocyte astrocyte NN cord-005146-o3roa7br 229 3 process process NN cord-005146-o3roa7br 229 4 is be VBZ cord-005146-o3roa7br 229 5 interposed interpose VBN cord-005146-o3roa7br 229 6 between between IN cord-005146-o3roa7br 229 7 them -PRON- PRP cord-005146-o3roa7br 229 8 . . . cord-005146-o3roa7br 230 1 x x LS cord-005146-o3roa7br 230 2 28 28 CD cord-005146-o3roa7br 230 3 000 000 CD cord-005146-o3roa7br 230 4 . . . cord-005146-o3roa7br 231 1 Harrison Harrison NNP cord-005146-o3roa7br 231 2 , , , cord-005146-o3roa7br 231 3 1985 1985 CD cord-005146-o3roa7br 231 4 ) ) -RRB- cord-005146-o3roa7br 231 5 . . . cord-005146-o3roa7br 232 1 In in IN cord-005146-o3roa7br 232 2 the the DT cord-005146-o3roa7br 232 3 present present JJ cord-005146-o3roa7br 232 4 study study NN cord-005146-o3roa7br 232 5 , , , cord-005146-o3roa7br 232 6 however however RB cord-005146-o3roa7br 232 7 , , , cord-005146-o3roa7br 232 8 there there EX cord-005146-o3roa7br 232 9 were be VBD cord-005146-o3roa7br 232 10 relatively relatively RB cord-005146-o3roa7br 232 11 greater great JJR cord-005146-o3roa7br 232 12 numbers number NNS cord-005146-o3roa7br 232 13 of of IN cord-005146-o3roa7br 232 14 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 232 15 in in IN cord-005146-o3roa7br 232 16 the the DT cord-005146-o3roa7br 232 17 CNS CNS NNP cord-005146-o3roa7br 232 18 - - HYPH cord-005146-o3roa7br 232 19 PNS PNS NNP cord-005146-o3roa7br 232 20 border border NN cord-005146-o3roa7br 232 21 zone zone NN cord-005146-o3roa7br 232 22 in in IN cord-005146-o3roa7br 232 23 which which WDT cord-005146-o3roa7br 232 24 astrocytes astrocyte NNS cord-005146-o3roa7br 232 25 and and CC cord-005146-o3roa7br 232 26 their -PRON- PRP$ cord-005146-o3roa7br 232 27 processes process NNS cord-005146-o3roa7br 232 28 were be VBD cord-005146-o3roa7br 232 29 sparse sparse JJ cord-005146-o3roa7br 232 30 . . . cord-005146-o3roa7br 233 1 This this DT cord-005146-o3roa7br 233 2 finding finding NN cord-005146-o3roa7br 233 3 indicates indicate VBZ cord-005146-o3roa7br 233 4 that that IN cord-005146-o3roa7br 233 5 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 233 6 can can MD cord-005146-o3roa7br 233 7 myelinate myelinate VB cord-005146-o3roa7br 233 8 d d NNP cord-005146-o3roa7br 233 9 e e NNP cord-005146-o3roa7br 233 10 n n NNP cord-005146-o3roa7br 233 11 u u NNP cord-005146-o3roa7br 233 12 d d NN cord-005146-o3roa7br 233 13 e e NNP cord-005146-o3roa7br 233 14 d d NNP cord-005146-o3roa7br 233 15 axons axon NNS cord-005146-o3roa7br 233 16 in in IN cord-005146-o3roa7br 233 17 the the DT cord-005146-o3roa7br 233 18 presence presence NN cord-005146-o3roa7br 233 19 of of IN cord-005146-o3roa7br 233 20 even even RB cord-005146-o3roa7br 233 21 only only RB cord-005146-o3roa7br 233 22 a a DT cord-005146-o3roa7br 233 23 few few JJ cord-005146-o3roa7br 233 24 astrocytes astrocyte NNS cord-005146-o3roa7br 233 25 . . . cord-005146-o3roa7br 233 26 _SP cord-005146-o3roa7br 234 1 Small small JJ cord-005146-o3roa7br 234 2 localized localized JJ cord-005146-o3roa7br 234 3 ultrasonic ultrasonic JJ cord-005146-o3roa7br 234 4 lesions lesion NNS cord-005146-o3roa7br 234 5 in in IN cord-005146-o3roa7br 234 6 the the DT cord-005146-o3roa7br 234 7 white white JJ cord-005146-o3roa7br 234 8 and and CC cord-005146-o3roa7br 234 9 gray gray JJ cord-005146-o3roa7br 234 10 matter matter NN cord-005146-o3roa7br 234 11 of of IN cord-005146-o3roa7br 234 12 the the DT cord-005146-o3roa7br 234 13 cat cat NN cord-005146-o3roa7br 234 14 brain brain NN cord-005146-o3roa7br 234 15 Remyelination Remyelination NNP cord-005146-o3roa7br 234 16 by by IN cord-005146-o3roa7br 234 17 Schwann Schwann NNP cord-005146-o3roa7br 234 18 cells cell NNS cord-005146-o3roa7br 234 19 of of IN cord-005146-o3roa7br 234 20 axons axon NNS cord-005146-o3roa7br 234 21 demyelinated demyelinate VBN cord-005146-o3roa7br 234 22 by by IN cord-005146-o3roa7br 234 23 intraspinal intraspinal JJ cord-005146-o3roa7br 234 24 injection injection NN cord-005146-o3roa7br 234 25 of of IN cord-005146-o3roa7br 234 26 6-aminonicotinamide 6-aminonicotinamide CD cord-005146-o3roa7br 234 27 in in IN cord-005146-o3roa7br 234 28 the the DT cord-005146-o3roa7br 234 29 rat rat NN cord-005146-o3roa7br 234 30 Remyelination Remyelination NNP cord-005146-o3roa7br 234 31 inmultiple inmultiple NN cord-005146-o3roa7br 234 32 sclerosis sclerosis NN cord-005146-o3roa7br 234 33 with with IN cord-005146-o3roa7br 234 34 peripheral peripheral JJ cord-005146-o3roa7br 234 35 type type NN cord-005146-o3roa7br 234 36 myelin myelin NN cord-005146-o3roa7br 234 37 On on IN cord-005146-o3roa7br 234 38 the the DT cord-005146-o3roa7br 234 39 presence presence NN cord-005146-o3roa7br 234 40 of of IN cord-005146-o3roa7br 234 41 peripheral peripheral JJ cord-005146-o3roa7br 234 42 - - HYPH cord-005146-o3roa7br 234 43 like like JJ cord-005146-o3roa7br 234 44 nervous nervous JJ cord-005146-o3roa7br 234 45 and and CC cord-005146-o3roa7br 234 46 connective connective JJ cord-005146-o3roa7br 234 47 tissue tissue NN cord-005146-o3roa7br 234 48 within within IN cord-005146-o3roa7br 234 49 irradiated irradiate VBN cord-005146-o3roa7br 234 50 spinal spinal JJ cord-005146-o3roa7br 234 51 cord cord NN cord-005146-o3roa7br 235 1 The the DT cord-005146-o3roa7br 235 2 role role NN cord-005146-o3roa7br 235 3 of of IN cord-005146-o3roa7br 235 4 Schwann Schwann NNP cord-005146-o3roa7br 235 5 cells cell NNS cord-005146-o3roa7br 235 6 in in IN cord-005146-o3roa7br 235 7 the the DT cord-005146-o3roa7br 235 8 repair repair NN cord-005146-o3roa7br 235 9 of of IN cord-005146-o3roa7br 235 10 glial glial JJ cord-005146-o3roa7br 235 11 cell cell NN cord-005146-o3roa7br 235 12 deficits deficit NNS cord-005146-o3roa7br 235 13 in in IN cord-005146-o3roa7br 235 14 the the DT cord-005146-o3roa7br 235 15 spinal spinal JJ cord-005146-o3roa7br 235 16 cord cord NN cord-005146-o3roa7br 235 17 Demyelination Demyelination NNP cord-005146-o3roa7br 235 18 and and CC cord-005146-o3roa7br 235 19 remyelination remyelination NN cord-005146-o3roa7br 235 20 after after IN cord-005146-o3roa7br 235 21 acute acute JJ cord-005146-o3roa7br 235 22 spinal spinal JJ cord-005146-o3roa7br 235 23 cord cord NN cord-005146-o3roa7br 235 24 compression compression NN cord-005146-o3roa7br 235 25 Delayed delay VBN cord-005146-o3roa7br 235 26 remyelination remyelination NN cord-005146-o3roa7br 235 27 in in IN cord-005146-o3roa7br 235 28 rat rat NN cord-005146-o3roa7br 235 29 spinal spinal JJ cord-005146-o3roa7br 235 30 cord cord NN cord-005146-o3roa7br 235 31 following follow VBG cord-005146-o3roa7br 235 32 ethidium ethidium NN cord-005146-o3roa7br 235 33 bromide bromide NN cord-005146-o3roa7br 235 34 injection injection NN cord-005146-o3roa7br 235 35 Nerve nerve NN cord-005146-o3roa7br 235 36 fibres fibre NNS cord-005146-o3roa7br 235 37 in in IN cord-005146-o3roa7br 235 38 spinal spinal JJ cord-005146-o3roa7br 235 39 cord cord NN cord-005146-o3roa7br 235 40 impact impact NN cord-005146-o3roa7br 235 41 injuries injury NNS cord-005146-o3roa7br 235 42 part part NN cord-005146-o3roa7br 235 43 1 1 CD cord-005146-o3roa7br 235 44 . . . cord-005146-o3roa7br 236 1 Changes change NNS cord-005146-o3roa7br 236 2 in in IN cord-005146-o3roa7br 236 3 the the DT cord-005146-o3roa7br 236 4 myelin myelin NN cord-005146-o3roa7br 236 5 sheath sheath NN cord-005146-o3roa7br 236 6 during during IN cord-005146-o3roa7br 236 7 the the DT cord-005146-o3roa7br 236 8 initial initial JJ cord-005146-o3roa7br 236 9 5 5 CD cord-005146-o3roa7br 236 10 weeks week NNS cord-005146-o3roa7br 236 11 Hyperthermia hyperthermia NN cord-005146-o3roa7br 236 12 and and CC cord-005146-o3roa7br 236 13 Cancer Cancer NNP cord-005146-o3roa7br 236 14 Degenerative degenerative JJ cord-005146-o3roa7br 236 15 changes change NNS cord-005146-o3roa7br 236 16 in in IN cord-005146-o3roa7br 236 17 rat rat NN cord-005146-o3roa7br 236 18 intraspinal intraspinal JJ cord-005146-o3roa7br 236 19 Schwann Schwann NNP cord-005146-o3roa7br 236 20 cells cell NNS cord-005146-o3roa7br 236 21 following follow VBG cord-005146-o3roa7br 236 22 tellurium tellurium NN cord-005146-o3roa7br 236 23 intoxication intoxication NN cord-005146-o3roa7br 236 24 Schwann Schwann NNP cord-005146-o3roa7br 236 25 cell cell NN cord-005146-o3roa7br 236 26 and and CC cord-005146-o3roa7br 236 27 oligodendrocyte oligodendrocyte NNP cord-005146-o3roa7br 236 28 remyelination remyelination NN cord-005146-o3roa7br 236 29 in in IN cord-005146-o3roa7br 236 30 lysolecithin lysolecithin NNP cord-005146-o3roa7br 236 31 - - HYPH cord-005146-o3roa7br 236 32 induced induce VBN cord-005146-o3roa7br 236 33 lesions lesion NNS cord-005146-o3roa7br 236 34 in in IN cord-005146-o3roa7br 236 35 irradiated irradiate VBN cord-005146-o3roa7br 236 36 rat rat NN cord-005146-o3roa7br 236 37 spinal spinal JJ cord-005146-o3roa7br 236 38 cord cord NN cord-005146-o3roa7br 236 39 Schwann Schwann NNP cord-005146-o3roa7br 236 40 cells cell NNS cord-005146-o3roa7br 236 41 divide divide VBP cord-005146-o3roa7br 236 42 in in IN cord-005146-o3roa7br 236 43 a a DT cord-005146-o3roa7br 236 44 demyelinating demyelinating JJ cord-005146-o3roa7br 236 45 lesion lesion NN cord-005146-o3roa7br 236 46 of of IN cord-005146-o3roa7br 236 47 the the DT cord-005146-o3roa7br 236 48 central central JJ cord-005146-o3roa7br 236 49 nervous nervous JJ cord-005146-o3roa7br 236 50 system system NN cord-005146-o3roa7br 236 51 Remyelination Remyelination NNP cord-005146-o3roa7br 236 52 after after IN cord-005146-o3roa7br 236 53 transient transient JJ cord-005146-o3roa7br 236 54 compression compression NN cord-005146-o3roa7br 236 55 of of IN cord-005146-o3roa7br 236 56 the the DT cord-005146-o3roa7br 236 57 spinal spinal JJ cord-005146-o3roa7br 236 58 cord cord NN cord-005146-o3roa7br 236 59 Central central JJ cord-005146-o3roa7br 236 60 demyelination demyelination NN cord-005146-o3roa7br 236 61 produced produce VBN cord-005146-o3roa7br 236 62 by by IN cord-005146-o3roa7br 236 63 diphtheria diphtheria NN cord-005146-o3roa7br 236 64 toxin toxin NN cord-005146-o3roa7br 236 65 : : : cord-005146-o3roa7br 236 66 an an DT cord-005146-o3roa7br 236 67 electron electron NN cord-005146-o3roa7br 236 68 microscopic microscopic JJ cord-005146-o3roa7br 236 69 study study NN cord-005146-o3roa7br 237 1 The the DT cord-005146-o3roa7br 237 2 pathology pathology NN cord-005146-o3roa7br 237 3 of of IN cord-005146-o3roa7br 237 4 the the DT cord-005146-o3roa7br 237 5 central central JJ cord-005146-o3roa7br 237 6 myelinated myelinated JJ cord-005146-o3roa7br 237 7 axon axon NN cord-005146-o3roa7br 237 8 Demyelination Demyelination NNP cord-005146-o3roa7br 237 9 and and CC cord-005146-o3roa7br 237 10 remyelination remyelination NN cord-005146-o3roa7br 237 11 in in IN cord-005146-o3roa7br 237 12 experimental experimental JJ cord-005146-o3roa7br 237 13 allergic allergic NN cord-005146-o3roa7br 237 14 encepahlomyelitis encepahlomyelitis NNP cord-005146-o3roa7br 237 15 Electron Electron NNP cord-005146-o3roa7br 237 16 microscopic microscopic JJ cord-005146-o3roa7br 237 17 studies study NNS cord-005146-o3roa7br 237 18 on on IN cord-005146-o3roa7br 237 19 ordinary ordinary JJ cord-005146-o3roa7br 237 20 and and CC cord-005146-o3roa7br 237 21 hyperacute hyperacute JJ cord-005146-o3roa7br 237 22 experimental experimental JJ cord-005146-o3roa7br 237 23 allergic allergic JJ cord-005146-o3roa7br 237 24 encephalomyelitis encephalomyelitis NN cord-005146-o3roa7br 237 25 Central central JJ cord-005146-o3roa7br 237 26 nervous nervous JJ cord-005146-o3roa7br 237 27 system system NN cord-005146-o3roa7br 237 28 demyelination demyelination NN cord-005146-o3roa7br 237 29 and and CC cord-005146-o3roa7br 237 30 remyelination remyelination NN cord-005146-o3roa7br 237 31 in in IN cord-005146-o3roa7br 237 32 the the DT cord-005146-o3roa7br 237 33 mouse mouse NN cord-005146-o3roa7br 237 34 . . . cord-005146-o3roa7br 238 1 An an DT cord-005146-o3roa7br 238 2 ultrastructural ultrastructural JJ cord-005146-o3roa7br 238 3 study study NN cord-005146-o3roa7br 238 4 of of IN cord-005146-o3roa7br 238 5 Cuprizone Cuprizone NNP cord-005146-o3roa7br 238 6 toxicity toxicity NN cord-005146-o3roa7br 238 7 Regeneration regeneration NN cord-005146-o3roa7br 238 8 of of IN cord-005146-o3roa7br 238 9 myelin myelin NN cord-005146-o3roa7br 238 10 and and CC cord-005146-o3roa7br 238 11 oligodendrocytes oligodendrocyte NNS cord-005146-o3roa7br 238 12 in in IN cord-005146-o3roa7br 238 13 the the DT cord-005146-o3roa7br 238 14 central central JJ cord-005146-o3roa7br 238 15 nervous nervous JJ cord-005146-o3roa7br 238 16 system system NN cord-005146-o3roa7br 238 17 Remyelination Remyelination NNP cord-005146-o3roa7br 238 18 in in IN cord-005146-o3roa7br 238 19 the the DT cord-005146-o3roa7br 238 20 central central JJ cord-005146-o3roa7br 238 21 nervous nervous JJ cord-005146-o3roa7br 238 22 system system NN cord-005146-o3roa7br 238 23 and and CC cord-005146-o3roa7br 238 24 the the DT cord-005146-o3roa7br 238 25 peripheral peripheral JJ cord-005146-o3roa7br 238 26 nervous nervous JJ cord-005146-o3roa7br 238 27 system system NN cord-005146-o3roa7br 238 28 Localized localize VBN cord-005146-o3roa7br 238 29 hyperthermia hyperthermia NN cord-005146-o3roa7br 238 30 in in IN cord-005146-o3roa7br 238 31 the the DT cord-005146-o3roa7br 238 32 treatment treatment NN cord-005146-o3roa7br 238 33 of of IN cord-005146-o3roa7br 238 34 malignant malignant JJ cord-005146-o3roa7br 238 35 brain brain NN cord-005146-o3roa7br 238 36 tumors tumor NNS cord-005146-o3roa7br 238 37 using use VBG cord-005146-o3roa7br 238 38 an an DT cord-005146-o3roa7br 238 39 interstitial interstitial JJ cord-005146-o3roa7br 238 40 microwave microwave NN cord-005146-o3roa7br 238 41 antenna antenna NN cord-005146-o3roa7br 238 42 array array NN cord-005146-o3roa7br 238 43 Chronic chronic JJ cord-005146-o3roa7br 238 44 histological histological JJ cord-005146-o3roa7br 238 45 effects effect NNS cord-005146-o3roa7br 238 46 of of IN cord-005146-o3roa7br 238 47 ultrasonic ultrasonic JJ cord-005146-o3roa7br 238 48 hyperthermia hyperthermia NN cord-005146-o3roa7br 238 49 on on IN cord-005146-o3roa7br 238 50 normal normal JJ cord-005146-o3roa7br 238 51 feline feline JJ cord-005146-o3roa7br 238 52 brain brain NN cord-005146-o3roa7br 238 53 tissue tissue NN cord-005146-o3roa7br 238 54 Increased increase VBN cord-005146-o3roa7br 238 55 blood blood NN cord-005146-o3roa7br 238 56 - - HYPH cord-005146-o3roa7br 238 57 brain brain NN cord-005146-o3roa7br 238 58 barrier barrier NN cord-005146-o3roa7br 238 59 permeability permeability NN cord-005146-o3roa7br 238 60 during during IN cord-005146-o3roa7br 238 61 hyperthermia hyperthermia NN cord-005146-o3roa7br 238 62 in in IN cord-005146-o3roa7br 238 63 the the DT cord-005146-o3roa7br 238 64 awake awake JJ cord-005146-o3roa7br 238 65 rat rat NN cord-005146-o3roa7br 238 66 Demyelinating demyelinate VBG cord-005146-o3roa7br 238 67 encephalomyelitis encephalomyelitis NN cord-005146-o3roa7br 238 68 induced induce VBN cord-005146-o3roa7br 238 69 by by IN cord-005146-o3roa7br 238 70 a a DT cord-005146-o3roa7br 238 71 long long JJ cord-005146-o3roa7br 238 72 - - HYPH cord-005146-o3roa7br 238 73 term term NN cord-005146-o3roa7br 238 74 corona corona NN cord-005146-o3roa7br 238 75 virus virus NN cord-005146-o3roa7br 238 76 infection infection NN cord-005146-o3roa7br 238 77 in in IN cord-005146-o3roa7br 238 78 rats rat NNS cord-005146-o3roa7br 238 79 Remyelination Remyelination NNP cord-005146-o3roa7br 238 80 in in IN cord-005146-o3roa7br 238 81 chronic chronic JJ cord-005146-o3roa7br 238 82 experimental experimental JJ cord-005146-o3roa7br 238 83 allergic allergic JJ cord-005146-o3roa7br 238 84 encephalomyelitis encephalomyelitis NN cord-005146-o3roa7br 238 85 and and CC cord-005146-o3roa7br 238 86 multiple multiple JJ cord-005146-o3roa7br 238 87 sclerosis sclerosis NN cord-005146-o3roa7br 238 88 Temperature temperature NN cord-005146-o3roa7br 238 89 - - HYPH cord-005146-o3roa7br 238 90 induced induce VBN cord-005146-o3roa7br 238 91 phase phase NN cord-005146-o3roa7br 238 92 changes change NNS cord-005146-o3roa7br 238 93 in in IN cord-005146-o3roa7br 238 94 mitochondrial mitochondrial JJ cord-005146-o3roa7br 238 95 membranes membrane NNS cord-005146-o3roa7br 238 96 detected detect VBN cord-005146-o3roa7br 238 97 by by IN cord-005146-o3roa7br 238 98 spin spin NN cord-005146-o3roa7br 238 99 labeling labeling NN cord-005146-o3roa7br 238 100 Interactions interaction NNS cord-005146-o3roa7br 238 101 between between IN cord-005146-o3roa7br 238 102 intraspinal intraspinal JJ cord-005146-o3roa7br 238 103 Schwann Schwann NNP cord-005146-o3roa7br 238 104 cells cell NNS cord-005146-o3roa7br 238 105 and and CC cord-005146-o3roa7br 238 106 the the DT cord-005146-o3roa7br 238 107 cellular cellular JJ cord-005146-o3roa7br 238 108 constituents constituent NNS cord-005146-o3roa7br 238 109 normally normally RB cord-005146-o3roa7br 238 110 occurring occur VBG cord-005146-o3roa7br 238 111 in in IN cord-005146-o3roa7br 238 112 the the DT cord-005146-o3roa7br 238 113 spinal spinal JJ cord-005146-o3roa7br 238 114 cord cord NN cord-005146-o3roa7br 238 115 : : : cord-005146-o3roa7br 239 1 an an DT cord-005146-o3roa7br 239 2 ultrastructural ultrastructural JJ cord-005146-o3roa7br 239 3 , , , cord-005146-o3roa7br 239 4 ~study ~study NNP cord-005146-o3roa7br 239 5 in in IN cord-005146-o3roa7br 239 6 the the DT cord-005146-o3roa7br 239 7 irradiated irradiate VBN cord-005146-o3roa7br 239 8 rat rat NN cord-005146-o3roa7br 239 9 P~ p~ NN cord-005146-o3roa7br 239 10 ( ( -LRB- cord-005146-o3roa7br 239 11 1975 1975 CD cord-005146-o3roa7br 239 12 ) ) -RRB- cord-005146-o3roa7br 239 13 Evidence evidence NN cord-005146-o3roa7br 239 14 that that IN cord-005146-o3roa7br 239 15 sensory sensory JJ cord-005146-o3roa7br 239 16 axons axon NNS cord-005146-o3roa7br 239 17 are be VBP cord-005146-o3roa7br 239 18 mitogenic mitogenic JJ cord-005146-o3roa7br 239 19 for for IN cord-005146-o3roa7br 239 20 Schwann Schwann NNP cord-005146-o3roa7br 239 21 cells cell NNS cord-005146-o3roa7br 240 1 The the DT cord-005146-o3roa7br 240 2 authors author NNS cord-005146-o3roa7br 240 3 wish wish VBP cord-005146-o3roa7br 240 4 to to TO cord-005146-o3roa7br 240 5 thank thank VB cord-005146-o3roa7br 240 6 Dr Dr NNP cord-005146-o3roa7br 240 7 T. T. NNP cord-005146-o3roa7br 240 8 Ushiki Ushiki NNP cord-005146-o3roa7br 240 9 and and CC cord-005146-o3roa7br 240 10 Dr Dr NNP cord-005146-o3roa7br 240 11 K. K. NNP cord-005146-o3roa7br 240 12 Tohyama Tohyama NNP cord-005146-o3roa7br 240 13 for for IN cord-005146-o3roa7br 240 14 their -PRON- PRP$ cord-005146-o3roa7br 240 15 kind kind NN cord-005146-o3roa7br 240 16 suggestions suggestion NNS cord-005146-o3roa7br 240 17 in in IN cord-005146-o3roa7br 240 18 th th XX cord-005146-o3roa7br 240 19 e e NN cord-005146-o3roa7br 240 20 preparation preparation NN cord-005146-o3roa7br 240 21 of of IN cord-005146-o3roa7br 240 22 manuscript manuscript NN cord-005146-o3roa7br 240 23 . . . cord-005146-o3roa7br 241 1 The the DT cord-005146-o3roa7br 241 2 authors author NNS cord-005146-o3roa7br 241 3 also also RB cord-005146-o3roa7br 241 4 thank thank VBP cord-005146-o3roa7br 241 5 Professor Professor NNP cord-005146-o3roa7br 241 6 Paul Paul NNP cord-005146-o3roa7br 241 7 Langman Langman NNP cord-005146-o3roa7br 241 8 for for IN cord-005146-o3roa7br 241 9 his -PRON- PRP$ cord-005146-o3roa7br 241 10 suggestions suggestion NNS cord-005146-o3roa7br 241 11 concerning concern VBG cord-005146-o3roa7br 241 12 English english JJ cord-005146-o3roa7br 241 13 usage usage NN cord-005146-o3roa7br 241 14 . . .