id sid tid token lemma pos cord-006824-btcdjmfp 1 1 key key NN cord-006824-btcdjmfp 1 2 : : : cord-006824-btcdjmfp 2 1 cord-006824-btcdjmfp cord-006824-btcdjmfp NNP cord-006824-btcdjmfp 2 2 authors author NNS cord-006824-btcdjmfp 2 3 : : : cord-006824-btcdjmfp 3 1 nan nan NNP cord-006824-btcdjmfp 3 2 title title NN cord-006824-btcdjmfp 3 3 : : : cord-006824-btcdjmfp 3 4 Key Key NNP cord-006824-btcdjmfp 3 5 Note Note NNP cord-006824-btcdjmfp 3 6 and and CC cord-006824-btcdjmfp 3 7 State State NNP cord-006824-btcdjmfp 3 8 of of IN cord-006824-btcdjmfp 3 9 the the DT cord-006824-btcdjmfp 3 10 Art Art NNP cord-006824-btcdjmfp 3 11 Lectures lecture NNS cord-006824-btcdjmfp 3 12 date date NN cord-006824-btcdjmfp 3 13 : : : cord-006824-btcdjmfp 3 14 2002 2002 CD cord-006824-btcdjmfp 3 15 - - HYPH cord-006824-btcdjmfp 3 16 09 09 CD cord-006824-btcdjmfp 3 17 - - HYPH cord-006824-btcdjmfp 3 18 07 07 CD cord-006824-btcdjmfp 3 19 journal journal NN cord-006824-btcdjmfp 3 20 : : : cord-006824-btcdjmfp 4 1 Ann Ann NNP cord-006824-btcdjmfp 4 2 Hematol Hematol NNP cord-006824-btcdjmfp 4 3 DOI DOI NNP cord-006824-btcdjmfp 4 4 : : : cord-006824-btcdjmfp 4 5 10.1007 10.1007 CD cord-006824-btcdjmfp 4 6 / / SYM cord-006824-btcdjmfp 4 7 s00277 s00277 CD cord-006824-btcdjmfp 4 8 - - HYPH cord-006824-btcdjmfp 4 9 002 002 CD cord-006824-btcdjmfp 4 10 - - HYPH cord-006824-btcdjmfp 4 11 0513 0513 CD cord-006824-btcdjmfp 4 12 - - SYM cord-006824-btcdjmfp 4 13 0 0 CD cord-006824-btcdjmfp 5 1 sha sha NNP cord-006824-btcdjmfp 5 2 : : : cord-006824-btcdjmfp 5 3 e163eae4e80d0cb9c23a5cbb06aba5c5dd3a9337 e163eae4e80d0cb9c23a5cbb06aba5c5dd3a9337 NNP cord-006824-btcdjmfp 5 4 doc_id doc_id CD cord-006824-btcdjmfp 5 5 : : : cord-006824-btcdjmfp 5 6 6824 6824 CD cord-006824-btcdjmfp 5 7 cord_uid cord_uid NNS cord-006824-btcdjmfp 5 8 : : : cord-006824-btcdjmfp 6 1 btcdjmfp btcdjmfp NNP cord-006824-btcdjmfp 6 2 nan nan NNP cord-006824-btcdjmfp 6 3 Non Non NNP cord-006824-btcdjmfp 6 4 - - NNP cord-006824-btcdjmfp 6 5 Hodgkin Hodgkin NNP cord-006824-btcdjmfp 6 6 's 's POS cord-006824-btcdjmfp 6 7 lymphoma lymphoma NN cord-006824-btcdjmfp 6 8 ( ( -LRB- cord-006824-btcdjmfp 6 9 NHL NHL NNP cord-006824-btcdjmfp 6 10 ) ) -RRB- cord-006824-btcdjmfp 6 11 is be VBZ cord-006824-btcdjmfp 6 12 a a DT cord-006824-btcdjmfp 6 13 hematologic hematologic JJ cord-006824-btcdjmfp 6 14 malignancy malignancy NN cord-006824-btcdjmfp 6 15 for for IN cord-006824-btcdjmfp 6 16 which which WDT cord-006824-btcdjmfp 6 17 a a DT cord-006824-btcdjmfp 6 18 rather rather RB cord-006824-btcdjmfp 6 19 dramatic dramatic JJ cord-006824-btcdjmfp 6 20 rise rise NN cord-006824-btcdjmfp 6 21 in in IN cord-006824-btcdjmfp 6 22 incidence incidence NN cord-006824-btcdjmfp 6 23 has have VBZ cord-006824-btcdjmfp 6 24 been be VBN cord-006824-btcdjmfp 6 25 noted note VBN cord-006824-btcdjmfp 6 26 during during IN cord-006824-btcdjmfp 6 27 the the DT cord-006824-btcdjmfp 6 28 past past JJ cord-006824-btcdjmfp 6 29 decade decade NN cord-006824-btcdjmfp 6 30 . . . cord-006824-btcdjmfp 7 1 NHL NHL NNP cord-006824-btcdjmfp 7 2 is be VBZ cord-006824-btcdjmfp 7 3 a a DT cord-006824-btcdjmfp 7 4 heterogeneous heterogeneous JJ cord-006824-btcdjmfp 7 5 condition condition NN cord-006824-btcdjmfp 7 6 in in IN cord-006824-btcdjmfp 7 7 every every DT cord-006824-btcdjmfp 7 8 respect respect NN cord-006824-btcdjmfp 7 9 . . . cord-006824-btcdjmfp 8 1 There there EX cord-006824-btcdjmfp 8 2 is be VBZ cord-006824-btcdjmfp 8 3 a a DT cord-006824-btcdjmfp 8 4 wide wide JJ cord-006824-btcdjmfp 8 5 range range NN cord-006824-btcdjmfp 8 6 of of IN cord-006824-btcdjmfp 8 7 histologic histologic JJ cord-006824-btcdjmfp 8 8 , , , cord-006824-btcdjmfp 8 9 immunologic immunologic JJ cord-006824-btcdjmfp 8 10 , , , cord-006824-btcdjmfp 8 11 molecular molecular JJ cord-006824-btcdjmfp 8 12 and and CC cord-006824-btcdjmfp 8 13 clinical clinical JJ cord-006824-btcdjmfp 8 14 expression expression NN cord-006824-btcdjmfp 8 15 of of IN cord-006824-btcdjmfp 8 16 this this DT cord-006824-btcdjmfp 8 17 condition condition NN cord-006824-btcdjmfp 8 18 with with IN cord-006824-btcdjmfp 8 19 marked marked JJ cord-006824-btcdjmfp 8 20 differences difference NNS cord-006824-btcdjmfp 8 21 in in IN cord-006824-btcdjmfp 8 22 response response NN cord-006824-btcdjmfp 8 23 to to IN cord-006824-btcdjmfp 8 24 therapy therapy NN cord-006824-btcdjmfp 8 25 and and CC cord-006824-btcdjmfp 8 26 survival survival NN cord-006824-btcdjmfp 8 27 . . . cord-006824-btcdjmfp 9 1 Various various JJ cord-006824-btcdjmfp 9 2 forms form NNS cord-006824-btcdjmfp 9 3 of of IN cord-006824-btcdjmfp 9 4 combination combination NN cord-006824-btcdjmfp 9 5 chemotherapy chemotherapy NN cord-006824-btcdjmfp 9 6 and and CC cord-006824-btcdjmfp 9 7 radiation radiation NN cord-006824-btcdjmfp 9 8 have have VBP cord-006824-btcdjmfp 9 9 been be VBN cord-006824-btcdjmfp 9 10 proven prove VBN cord-006824-btcdjmfp 9 11 to to TO cord-006824-btcdjmfp 9 12 be be VB cord-006824-btcdjmfp 9 13 successful successful JJ cord-006824-btcdjmfp 9 14 for for IN cord-006824-btcdjmfp 9 15 the the DT cord-006824-btcdjmfp 9 16 different different JJ cord-006824-btcdjmfp 9 17 types type NNS cord-006824-btcdjmfp 9 18 of of IN cord-006824-btcdjmfp 9 19 NHL NHL NNP cord-006824-btcdjmfp 9 20 , , , cord-006824-btcdjmfp 9 21 however however RB cord-006824-btcdjmfp 9 22 , , , cord-006824-btcdjmfp 9 23 on on IN cord-006824-btcdjmfp 9 24 average average JJ cord-006824-btcdjmfp 9 25 only only RB cord-006824-btcdjmfp 9 26 one one CD cord-006824-btcdjmfp 9 27 - - HYPH cord-006824-btcdjmfp 9 28 half half NN cord-006824-btcdjmfp 9 29 of of IN cord-006824-btcdjmfp 9 30 the the DT cord-006824-btcdjmfp 9 31 patient patient JJ cord-006824-btcdjmfp 9 32 population population NN cord-006824-btcdjmfp 9 33 with with IN cord-006824-btcdjmfp 9 34 disseminated disseminate VBN cord-006824-btcdjmfp 9 35 disease disease NN cord-006824-btcdjmfp 9 36 enters enter VBZ cord-006824-btcdjmfp 9 37 a a DT cord-006824-btcdjmfp 9 38 durable durable JJ cord-006824-btcdjmfp 9 39 remission remission NN cord-006824-btcdjmfp 9 40 [ [ -LRB- cord-006824-btcdjmfp 9 41 1 1 CD cord-006824-btcdjmfp 9 42 ] ] -RRB- cord-006824-btcdjmfp 9 43 . . . cord-006824-btcdjmfp 10 1 During during IN cord-006824-btcdjmfp 10 2 the the DT cord-006824-btcdjmfp 10 3 past past JJ cord-006824-btcdjmfp 10 4 25 25 CD cord-006824-btcdjmfp 10 5 years year NNS cord-006824-btcdjmfp 10 6 , , , cord-006824-btcdjmfp 10 7 many many JJ cord-006824-btcdjmfp 10 8 investigators investigator NNS cord-006824-btcdjmfp 10 9 have have VBP cord-006824-btcdjmfp 10 10 explored explore VBN cord-006824-btcdjmfp 10 11 various various JJ cord-006824-btcdjmfp 10 12 forms form NNS cord-006824-btcdjmfp 10 13 of of IN cord-006824-btcdjmfp 10 14 high high JJ cord-006824-btcdjmfp 10 15 dose dose NN cord-006824-btcdjmfp 10 16 therapy therapy NN cord-006824-btcdjmfp 10 17 followed follow VBN cord-006824-btcdjmfp 10 18 by by IN cord-006824-btcdjmfp 10 19 either either CC cord-006824-btcdjmfp 10 20 autologous autologous JJ cord-006824-btcdjmfp 10 21 or or CC cord-006824-btcdjmfp 10 22 allogeneic allogeneic IN cord-006824-btcdjmfp 10 23 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 10 24 cell cell NN cord-006824-btcdjmfp 10 25 transplantation transplantation NN cord-006824-btcdjmfp 10 26 . . . cord-006824-btcdjmfp 11 1 This this DT cord-006824-btcdjmfp 11 2 review review NN cord-006824-btcdjmfp 11 3 will will MD cord-006824-btcdjmfp 11 4 present present VB cord-006824-btcdjmfp 11 5 some some DT cord-006824-btcdjmfp 11 6 of of IN cord-006824-btcdjmfp 11 7 the the DT cord-006824-btcdjmfp 11 8 original original JJ cord-006824-btcdjmfp 11 9 data datum NNS cord-006824-btcdjmfp 11 10 and and CC cord-006824-btcdjmfp 11 11 provide provide VB cord-006824-btcdjmfp 11 12 new new JJ cord-006824-btcdjmfp 11 13 information information NN cord-006824-btcdjmfp 11 14 from from IN cord-006824-btcdjmfp 11 15 more more RBR cord-006824-btcdjmfp 11 16 recently recently RB cord-006824-btcdjmfp 11 17 published publish VBN cord-006824-btcdjmfp 11 18 clinical clinical JJ cord-006824-btcdjmfp 11 19 trials trial NNS cord-006824-btcdjmfp 11 20 . . . cord-006824-btcdjmfp 12 1 The the DT cord-006824-btcdjmfp 12 2 first first JJ cord-006824-btcdjmfp 12 3 group group NN cord-006824-btcdjmfp 12 4 of of IN cord-006824-btcdjmfp 12 5 patients patient NNS cord-006824-btcdjmfp 12 6 treated treat VBN cord-006824-btcdjmfp 12 7 with with IN cord-006824-btcdjmfp 12 8 high high JJ cord-006824-btcdjmfp 12 9 dose dose NN cord-006824-btcdjmfp 12 10 combination combination NN cord-006824-btcdjmfp 12 11 therapy therapy NN cord-006824-btcdjmfp 12 12 followed follow VBN cord-006824-btcdjmfp 12 13 by by IN cord-006824-btcdjmfp 12 14 autologous autologous JJ cord-006824-btcdjmfp 12 15 HCT HCT NNP cord-006824-btcdjmfp 12 16 dates date NNS cord-006824-btcdjmfp 12 17 back back RB cord-006824-btcdjmfp 12 18 to to IN cord-006824-btcdjmfp 12 19 1978 1978 CD cord-006824-btcdjmfp 12 20 . . . cord-006824-btcdjmfp 13 1 In in IN cord-006824-btcdjmfp 13 2 a a DT cord-006824-btcdjmfp 13 3 report report NN cord-006824-btcdjmfp 13 4 from from IN cord-006824-btcdjmfp 13 5 the the DT cord-006824-btcdjmfp 13 6 National National NNP cord-006824-btcdjmfp 13 7 Cancer Cancer NNP cord-006824-btcdjmfp 13 8 Institute Institute NNP cord-006824-btcdjmfp 13 9 , , , cord-006824-btcdjmfp 13 10 12 12 CD cord-006824-btcdjmfp 13 11 NHL NHL NNP cord-006824-btcdjmfp 13 12 patients patient NNS cord-006824-btcdjmfp 13 13 were be VBD cord-006824-btcdjmfp 13 14 described describe VBN cord-006824-btcdjmfp 13 15 of of IN cord-006824-btcdjmfp 13 16 whom whom WP cord-006824-btcdjmfp 13 17 four four CD cord-006824-btcdjmfp 13 18 currently currently RB cord-006824-btcdjmfp 13 19 are be VBP cord-006824-btcdjmfp 13 20 alive alive JJ cord-006824-btcdjmfp 13 21 and and CC cord-006824-btcdjmfp 13 22 well well RB cord-006824-btcdjmfp 13 23 more more JJR cord-006824-btcdjmfp 13 24 than than IN cord-006824-btcdjmfp 13 25 25 25 CD cord-006824-btcdjmfp 13 26 years year NNS cord-006824-btcdjmfp 13 27 after after IN cord-006824-btcdjmfp 13 28 HCT HCT NNP cord-006824-btcdjmfp 13 29 [ [ -LRB- cord-006824-btcdjmfp 13 30 2 2 CD cord-006824-btcdjmfp 13 31 ] ] -RRB- cord-006824-btcdjmfp 13 32 . . . cord-006824-btcdjmfp 14 1 This this DT cord-006824-btcdjmfp 14 2 encouraging encouraging JJ cord-006824-btcdjmfp 14 3 observation observation NN cord-006824-btcdjmfp 14 4 was be VBD cord-006824-btcdjmfp 14 5 followed follow VBN cord-006824-btcdjmfp 14 6 by by IN cord-006824-btcdjmfp 14 7 a a DT cord-006824-btcdjmfp 14 8 large large JJ cord-006824-btcdjmfp 14 9 number number NN cord-006824-btcdjmfp 14 10 of of IN cord-006824-btcdjmfp 14 11 clinical clinical JJ cord-006824-btcdjmfp 14 12 trials trial NNS cord-006824-btcdjmfp 14 13 , , , cord-006824-btcdjmfp 14 14 mostly mostly RB cord-006824-btcdjmfp 14 15 designed design VBN cord-006824-btcdjmfp 14 16 as as IN cord-006824-btcdjmfp 14 17 feasibility feasibility NN cord-006824-btcdjmfp 14 18 trials trial NNS cord-006824-btcdjmfp 14 19 or or CC cord-006824-btcdjmfp 14 20 phase phase NN cord-006824-btcdjmfp 14 21 II ii CD cord-006824-btcdjmfp 14 22 studies study NNS cord-006824-btcdjmfp 14 23 . . . cord-006824-btcdjmfp 15 1 A a DT cord-006824-btcdjmfp 15 2 comparison comparison NN cord-006824-btcdjmfp 15 3 between between IN cord-006824-btcdjmfp 15 4 high high JJ cord-006824-btcdjmfp 15 5 dose dose NN cord-006824-btcdjmfp 15 6 therapy therapy NN cord-006824-btcdjmfp 15 7 and and CC cord-006824-btcdjmfp 15 8 autologous autologous JJ cord-006824-btcdjmfp 15 9 HCT hct NN cord-006824-btcdjmfp 15 10 versus versus IN cord-006824-btcdjmfp 15 11 standard standard JJ cord-006824-btcdjmfp 15 12 dose dose NN cord-006824-btcdjmfp 15 13 chemotherapy chemotherapy NN cord-006824-btcdjmfp 15 14 was be VBD cord-006824-btcdjmfp 15 15 reported report VBN cord-006824-btcdjmfp 15 16 in in IN cord-006824-btcdjmfp 15 17 1995 1995 CD cord-006824-btcdjmfp 15 18 and and CC cord-006824-btcdjmfp 15 19 demonstrated demonstrate VBD cord-006824-btcdjmfp 15 20 a a DT cord-006824-btcdjmfp 15 21 significant significant JJ cord-006824-btcdjmfp 15 22 advantage advantage NN cord-006824-btcdjmfp 15 23 with with IN cord-006824-btcdjmfp 15 24 respect respect NN cord-006824-btcdjmfp 15 25 to to IN cord-006824-btcdjmfp 15 26 overall overall JJ cord-006824-btcdjmfp 15 27 survival survival NN cord-006824-btcdjmfp 15 28 and and CC cord-006824-btcdjmfp 15 29 disease disease NN cord-006824-btcdjmfp 15 30 - - HYPH cord-006824-btcdjmfp 15 31 free free JJ cord-006824-btcdjmfp 15 32 survival survival NN cord-006824-btcdjmfp 15 33 in in IN cord-006824-btcdjmfp 15 34 favor favor NN cord-006824-btcdjmfp 15 35 of of IN cord-006824-btcdjmfp 15 36 transplantation transplantation NN cord-006824-btcdjmfp 15 37 [ [ -LRB- cord-006824-btcdjmfp 15 38 3 3 CD cord-006824-btcdjmfp 15 39 ] ] -RRB- cord-006824-btcdjmfp 15 40 . . . cord-006824-btcdjmfp 16 1 During during IN cord-006824-btcdjmfp 16 2 the the DT cord-006824-btcdjmfp 16 3 past past JJ cord-006824-btcdjmfp 16 4 decade decade NN cord-006824-btcdjmfp 16 5 , , , cord-006824-btcdjmfp 16 6 patients patient NNS cord-006824-btcdjmfp 16 7 with with IN cord-006824-btcdjmfp 16 8 NHL NHL NNP cord-006824-btcdjmfp 16 9 who who WP cord-006824-btcdjmfp 16 10 had have VBD cord-006824-btcdjmfp 16 11 high high JJ cord-006824-btcdjmfp 16 12 risk risk NN cord-006824-btcdjmfp 16 13 features feature NNS cord-006824-btcdjmfp 16 14 have have VBP cord-006824-btcdjmfp 16 15 been be VBN cord-006824-btcdjmfp 16 16 transplanted transplant VBN cord-006824-btcdjmfp 16 17 electively electively RB cord-006824-btcdjmfp 16 18 during during IN cord-006824-btcdjmfp 16 19 their -PRON- PRP$ cord-006824-btcdjmfp 16 20 first first JJ cord-006824-btcdjmfp 16 21 clinical clinical JJ cord-006824-btcdjmfp 16 22 remission remission NN cord-006824-btcdjmfp 16 23 in in IN cord-006824-btcdjmfp 16 24 order order NN cord-006824-btcdjmfp 16 25 to to TO cord-006824-btcdjmfp 16 26 avoid avoid VB cord-006824-btcdjmfp 16 27 an an DT cord-006824-btcdjmfp 16 28 early early JJ cord-006824-btcdjmfp 16 29 relapse relapse NN cord-006824-btcdjmfp 16 30 . . . cord-006824-btcdjmfp 17 1 These these DT cord-006824-btcdjmfp 17 2 extended extend VBN cord-006824-btcdjmfp 17 3 phase phase NN cord-006824-btcdjmfp 17 4 II ii CD cord-006824-btcdjmfp 17 5 trials trial NNS cord-006824-btcdjmfp 17 6 have have VBP cord-006824-btcdjmfp 17 7 yielded yield VBN cord-006824-btcdjmfp 17 8 promising promising JJ cord-006824-btcdjmfp 17 9 results result NNS cord-006824-btcdjmfp 17 10 . . . cord-006824-btcdjmfp 18 1 A a DT cord-006824-btcdjmfp 18 2 prospective prospective JJ cord-006824-btcdjmfp 18 3 comparison comparison NN cord-006824-btcdjmfp 18 4 showing show VBG cord-006824-btcdjmfp 18 5 the the DT cord-006824-btcdjmfp 18 6 advantage advantage NN cord-006824-btcdjmfp 18 7 of of IN cord-006824-btcdjmfp 18 8 high high JJ cord-006824-btcdjmfp 18 9 dose dose NN cord-006824-btcdjmfp 18 10 sequential sequential JJ cord-006824-btcdjmfp 18 11 therapy therapy NN cord-006824-btcdjmfp 18 12 versus versus IN cord-006824-btcdjmfp 18 13 continued continued JJ cord-006824-btcdjmfp 18 14 standard standard JJ cord-006824-btcdjmfp 18 15 dose dose NN cord-006824-btcdjmfp 18 16 therapy therapy NN cord-006824-btcdjmfp 18 17 was be VBD cord-006824-btcdjmfp 18 18 reported report VBN cord-006824-btcdjmfp 18 19 five five CD cord-006824-btcdjmfp 18 20 years year NNS cord-006824-btcdjmfp 18 21 ago ago RB cord-006824-btcdjmfp 18 22 [ [ -LRB- cord-006824-btcdjmfp 18 23 4 4 CD cord-006824-btcdjmfp 18 24 ] ] -RRB- cord-006824-btcdjmfp 18 25 . . . cord-006824-btcdjmfp 19 1 The the DT cord-006824-btcdjmfp 19 2 leading leading JJ cord-006824-btcdjmfp 19 3 cause cause NN cord-006824-btcdjmfp 19 4 for for IN cord-006824-btcdjmfp 19 5 treatment treatment NN cord-006824-btcdjmfp 19 6 failure failure NN cord-006824-btcdjmfp 19 7 after after IN cord-006824-btcdjmfp 19 8 autologous autologous JJ cord-006824-btcdjmfp 19 9 HCT hct NN cord-006824-btcdjmfp 19 10 for for IN cord-006824-btcdjmfp 19 11 NHL NHL NNP cord-006824-btcdjmfp 19 12 is be VBZ cord-006824-btcdjmfp 19 13 the the DT cord-006824-btcdjmfp 19 14 relapse relapse NN cord-006824-btcdjmfp 19 15 of of IN cord-006824-btcdjmfp 19 16 the the DT cord-006824-btcdjmfp 19 17 underlying underlie VBG cord-006824-btcdjmfp 19 18 disease disease NN cord-006824-btcdjmfp 19 19 . . . cord-006824-btcdjmfp 20 1 A a DT cord-006824-btcdjmfp 20 2 number number NN cord-006824-btcdjmfp 20 3 of of IN cord-006824-btcdjmfp 20 4 strategies strategy NNS cord-006824-btcdjmfp 20 5 to to TO cord-006824-btcdjmfp 20 6 improve improve VB cord-006824-btcdjmfp 20 7 the the DT cord-006824-btcdjmfp 20 8 outcome outcome NN cord-006824-btcdjmfp 20 9 of of IN cord-006824-btcdjmfp 20 10 autologous autologous JJ cord-006824-btcdjmfp 20 11 HCT hct NN cord-006824-btcdjmfp 20 12 can can MD cord-006824-btcdjmfp 20 13 be be VB cord-006824-btcdjmfp 20 14 pursued pursue VBN cord-006824-btcdjmfp 20 15 ( ( -LRB- cord-006824-btcdjmfp 20 16 see see VB cord-006824-btcdjmfp 20 17 Table table NN cord-006824-btcdjmfp 20 18 1 1 CD cord-006824-btcdjmfp 20 19 ) ) -RRB- cord-006824-btcdjmfp 20 20 . . . cord-006824-btcdjmfp 21 1 In in IN cord-006824-btcdjmfp 21 2 this this DT cord-006824-btcdjmfp 21 3 presentation presentation NN cord-006824-btcdjmfp 21 4 , , , cord-006824-btcdjmfp 21 5 I -PRON- PRP cord-006824-btcdjmfp 21 6 will will MD cord-006824-btcdjmfp 21 7 show show VB cord-006824-btcdjmfp 21 8 several several JJ cord-006824-btcdjmfp 21 9 examples example NNS cord-006824-btcdjmfp 21 10 which which WDT cord-006824-btcdjmfp 21 11 indicate indicate VBP cord-006824-btcdjmfp 21 12 the the DT cord-006824-btcdjmfp 21 13 importance importance NN cord-006824-btcdjmfp 21 14 of of IN cord-006824-btcdjmfp 21 15 some some DT cord-006824-btcdjmfp 21 16 of of IN cord-006824-btcdjmfp 21 17 the the DT cord-006824-btcdjmfp 21 18 treatment treatment NN cord-006824-btcdjmfp 21 19 strategies strategy NNS cord-006824-btcdjmfp 21 20 mentioned mention VBN cord-006824-btcdjmfp 21 21 in in IN cord-006824-btcdjmfp 21 22 Table Table NNP cord-006824-btcdjmfp 21 23 1 1 CD cord-006824-btcdjmfp 21 24 [ [ -LRB- cord-006824-btcdjmfp 21 25 5 5 CD cord-006824-btcdjmfp 21 26 ] ] -RRB- cord-006824-btcdjmfp 21 27 . . . cord-006824-btcdjmfp 22 1 Table table NN cord-006824-btcdjmfp 22 2 1 1 CD cord-006824-btcdjmfp 22 3 . . . cord-006824-btcdjmfp 23 1 Opportunities opportunity NNS cord-006824-btcdjmfp 23 2 to to TO cord-006824-btcdjmfp 23 3 Improve improve VB cord-006824-btcdjmfp 23 4 the the DT cord-006824-btcdjmfp 23 5 Outcome outcome NN cord-006824-btcdjmfp 23 6 of of IN cord-006824-btcdjmfp 23 7 Autologous autologous JJ cord-006824-btcdjmfp 23 8 Hematopoietic Hematopoietic NNP cord-006824-btcdjmfp 23 9 Cell Cell NNP cord-006824-btcdjmfp 23 10 Transplantation transplantation NN cord-006824-btcdjmfp 24 1 • • NNP cord-006824-btcdjmfp 25 1 Timing timing NN cord-006824-btcdjmfp 25 2 of of IN cord-006824-btcdjmfp 25 3 autologous autologous JJ cord-006824-btcdjmfp 25 4 HCT hct NN cord-006824-btcdjmfp 25 5 with with IN cord-006824-btcdjmfp 25 6 respect respect NN cord-006824-btcdjmfp 25 7 to to IN cord-006824-btcdjmfp 25 8 remission remission NN cord-006824-btcdjmfp 25 9 status status NN cord-006824-btcdjmfp 26 1 • • NNP cord-006824-btcdjmfp 27 1 Selection selection NN cord-006824-btcdjmfp 27 2 of of IN cord-006824-btcdjmfp 27 3 myeloablative myeloablative JJ cord-006824-btcdjmfp 27 4 doses dose NNS cord-006824-btcdjmfp 27 5 and and CC cord-006824-btcdjmfp 27 6 combinations combination NNS cord-006824-btcdjmfp 27 7 of of IN cord-006824-btcdjmfp 27 8 drugs drug NNS cord-006824-btcdjmfp 27 9 with with IN cord-006824-btcdjmfp 27 10 or or CC cord-006824-btcdjmfp 27 11 without without IN cord-006824-btcdjmfp 27 12 irradiation irradiation NN cord-006824-btcdjmfp 27 13 • • NN cord-006824-btcdjmfp 28 1 Optimizing optimize VBG cord-006824-btcdjmfp 28 2 the the DT cord-006824-btcdjmfp 28 3 graft graft NN cord-006824-btcdjmfp 28 4 , , , cord-006824-btcdjmfp 28 5 i.e. i.e. FW cord-006824-btcdjmfp 28 6 , , , cord-006824-btcdjmfp 28 7 removal removal NN cord-006824-btcdjmfp 28 8 of of IN cord-006824-btcdjmfp 28 9 clonogenic clonogenic JJ cord-006824-btcdjmfp 28 10 tumors tumor NNS cord-006824-btcdjmfp 28 11 without without IN cord-006824-btcdjmfp 28 12 loss loss NN cord-006824-btcdjmfp 28 13 of of IN cord-006824-btcdjmfp 28 14 activity activity NN cord-006824-btcdjmfp 28 15 for for IN cord-006824-btcdjmfp 28 16 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 28 17 reconstitution reconstitution NN cord-006824-btcdjmfp 29 1 • • NNP cord-006824-btcdjmfp 30 1 Post post JJ cord-006824-btcdjmfp 30 2 - - JJ cord-006824-btcdjmfp 30 3 autologous autologous JJ cord-006824-btcdjmfp 30 4 HCT hct NN cord-006824-btcdjmfp 30 5 to to TO cord-006824-btcdjmfp 30 6 consolidate consolidate VB cord-006824-btcdjmfp 30 7 remission remission NN cord-006824-btcdjmfp 30 8 ( ( -LRB- cord-006824-btcdjmfp 30 9 cytokines cytokine NNS cord-006824-btcdjmfp 30 10 , , , cord-006824-btcdjmfp 30 11 monoclonal monoclonal JJ cord-006824-btcdjmfp 30 12 antibodies antibody NNS cord-006824-btcdjmfp 30 13 , , , cord-006824-btcdjmfp 30 14 vaccines vaccine NNS cord-006824-btcdjmfp 30 15 , , , cord-006824-btcdjmfp 30 16 cells cell NNS cord-006824-btcdjmfp 30 17 , , , cord-006824-btcdjmfp 30 18 involved involve VBN cord-006824-btcdjmfp 30 19 - - HYPH cord-006824-btcdjmfp 30 20 field field NN cord-006824-btcdjmfp 30 21 radiation radiation NN cord-006824-btcdjmfp 30 22 ) ) -RRB- cord-006824-btcdjmfp 31 1 The the DT cord-006824-btcdjmfp 31 2 timing timing NN cord-006824-btcdjmfp 31 3 of of IN cord-006824-btcdjmfp 31 4 high high JJ cord-006824-btcdjmfp 31 5 dose dose NN cord-006824-btcdjmfp 31 6 therapy therapy NN cord-006824-btcdjmfp 31 7 and and CC cord-006824-btcdjmfp 31 8 autologous autologous JJ cord-006824-btcdjmfp 31 9 HCT hct NN cord-006824-btcdjmfp 31 10 can can MD cord-006824-btcdjmfp 31 11 have have VB cord-006824-btcdjmfp 31 12 a a DT cord-006824-btcdjmfp 31 13 major major JJ cord-006824-btcdjmfp 31 14 influence influence NN cord-006824-btcdjmfp 31 15 upon upon IN cord-006824-btcdjmfp 31 16 the the DT cord-006824-btcdjmfp 31 17 treatment treatment NN cord-006824-btcdjmfp 31 18 result result NN cord-006824-btcdjmfp 31 19 . . . cord-006824-btcdjmfp 32 1 In in IN cord-006824-btcdjmfp 32 2 a a DT cord-006824-btcdjmfp 32 3 prospective prospective JJ cord-006824-btcdjmfp 32 4 phase phase NN cord-006824-btcdjmfp 32 5 II II NNP cord-006824-btcdjmfp 32 6 trial trial NN cord-006824-btcdjmfp 32 7 , , , cord-006824-btcdjmfp 32 8 we -PRON- PRP cord-006824-btcdjmfp 32 9 treated treat VBD cord-006824-btcdjmfp 32 10 37 37 CD cord-006824-btcdjmfp 32 11 patients patient NNS cord-006824-btcdjmfp 32 12 with with IN cord-006824-btcdjmfp 32 13 high high JJ cord-006824-btcdjmfp 32 14 dose dose NN cord-006824-btcdjmfp 32 15 therapy therapy NN cord-006824-btcdjmfp 32 16 and and CC cord-006824-btcdjmfp 32 17 autologous autologous JJ cord-006824-btcdjmfp 32 18 bone bone NN cord-006824-btcdjmfp 32 19 marrow marrow NN cord-006824-btcdjmfp 32 20 transplantation transplantation NN cord-006824-btcdjmfp 32 21 for for IN cord-006824-btcdjmfp 32 22 follicular follicular JJ cord-006824-btcdjmfp 32 23 lymphoma lymphoma NN cord-006824-btcdjmfp 32 24 in in IN cord-006824-btcdjmfp 32 25 first first JJ cord-006824-btcdjmfp 32 26 complete complete JJ cord-006824-btcdjmfp 32 27 or or CC cord-006824-btcdjmfp 32 28 partial partial JJ cord-006824-btcdjmfp 32 29 remission remission NN cord-006824-btcdjmfp 32 30 [ [ -LRB- cord-006824-btcdjmfp 32 31 6 6 CD cord-006824-btcdjmfp 32 32 ] ] -RRB- cord-006824-btcdjmfp 32 33 . . . cord-006824-btcdjmfp 33 1 Seventeen seventeen CD cord-006824-btcdjmfp 33 2 patients patient NNS cord-006824-btcdjmfp 33 3 were be VBD cord-006824-btcdjmfp 33 4 in in IN cord-006824-btcdjmfp 33 5 first first JJ cord-006824-btcdjmfp 33 6 complete complete JJ cord-006824-btcdjmfp 33 7 remission remission NN cord-006824-btcdjmfp 33 8 and and CC cord-006824-btcdjmfp 33 9 20 20 CD cord-006824-btcdjmfp 33 10 patients patient NNS cord-006824-btcdjmfp 33 11 were be VBD cord-006824-btcdjmfp 33 12 in in IN cord-006824-btcdjmfp 33 13 partial partial JJ cord-006824-btcdjmfp 33 14 remission remission NN cord-006824-btcdjmfp 33 15 . . . cord-006824-btcdjmfp 34 1 The the DT cord-006824-btcdjmfp 34 2 median median JJ cord-006824-btcdjmfp 34 3 age age NN cord-006824-btcdjmfp 34 4 of of IN cord-006824-btcdjmfp 34 5 this this DT cord-006824-btcdjmfp 34 6 patient patient JJ cord-006824-btcdjmfp 34 7 population population NN cord-006824-btcdjmfp 34 8 was be VBD cord-006824-btcdjmfp 34 9 37 37 CD cord-006824-btcdjmfp 34 10 years year NNS cord-006824-btcdjmfp 34 11 ranging range VBG cord-006824-btcdjmfp 34 12 from from IN cord-006824-btcdjmfp 34 13 24 24 CD cord-006824-btcdjmfp 34 14 to to TO cord-006824-btcdjmfp 34 15 49 49 CD cord-006824-btcdjmfp 34 16 years year NNS cord-006824-btcdjmfp 34 17 . . . cord-006824-btcdjmfp 35 1 The the DT cord-006824-btcdjmfp 35 2 preparatory preparatory JJ cord-006824-btcdjmfp 35 3 regimen regimen NN cord-006824-btcdjmfp 35 4 consisted consist VBD cord-006824-btcdjmfp 35 5 of of IN cord-006824-btcdjmfp 35 6 fractionated fractionated JJ cord-006824-btcdjmfp 35 7 total total JJ cord-006824-btcdjmfp 35 8 body body NN cord-006824-btcdjmfp 35 9 irradiation irradiation NN cord-006824-btcdjmfp 35 10 ( ( -LRB- cord-006824-btcdjmfp 35 11 1,200 1,200 CD cord-006824-btcdjmfp 35 12 cGy cGy NNS cord-006824-btcdjmfp 35 13 ) ) -RRB- cord-006824-btcdjmfp 35 14 , , , cord-006824-btcdjmfp 35 15 etoposide etoposide JJ cord-006824-btcdjmfp 35 16 ( ( -LRB- cord-006824-btcdjmfp 35 17 60 60 CD cord-006824-btcdjmfp 35 18 mg mg NNP cord-006824-btcdjmfp 35 19 / / SYM cord-006824-btcdjmfp 35 20 kg kg NNP cord-006824-btcdjmfp 35 21 ) ) -RRB- cord-006824-btcdjmfp 35 22 and and CC cord-006824-btcdjmfp 35 23 cy cy NNP cord-006824-btcdjmfp 35 24 - - HYPH cord-006824-btcdjmfp 35 25 clophosphamide clophosphamide NNP cord-006824-btcdjmfp 35 26 ( ( -LRB- cord-006824-btcdjmfp 35 27 100 100 CD cord-006824-btcdjmfp 35 28 mg mg NNP cord-006824-btcdjmfp 35 29 / / SYM cord-006824-btcdjmfp 35 30 kg kg NNP cord-006824-btcdjmfp 35 31 ) ) -RRB- cord-006824-btcdjmfp 35 32 . . . cord-006824-btcdjmfp 36 1 All all DT cord-006824-btcdjmfp 36 2 patients patient NNS cord-006824-btcdjmfp 36 3 received receive VBD cord-006824-btcdjmfp 36 4 autologous autologous JJ cord-006824-btcdjmfp 36 5 bone bone NN cord-006824-btcdjmfp 36 6 marrow marrow NN cord-006824-btcdjmfp 36 7 cells cell NNS cord-006824-btcdjmfp 36 8 which which WDT cord-006824-btcdjmfp 36 9 were be VBD cord-006824-btcdjmfp 36 10 purged purge VBN cord-006824-btcdjmfp 36 11 with with IN cord-006824-btcdjmfp 36 12 a a DT cord-006824-btcdjmfp 36 13 set set NN cord-006824-btcdjmfp 36 14 of of IN cord-006824-btcdjmfp 36 15 monoclonal monoclonal JJ cord-006824-btcdjmfp 36 16 antibodies antibody NNS cord-006824-btcdjmfp 36 17 directed direct VBN cord-006824-btcdjmfp 36 18 against against IN cord-006824-btcdjmfp 36 19 CD9 CD9 NNP cord-006824-btcdjmfp 36 20 , , , cord-006824-btcdjmfp 36 21 CD10 CD10 NNP cord-006824-btcdjmfp 36 22 , , , cord-006824-btcdjmfp 36 23 CD19 CD19 NNP cord-006824-btcdjmfp 36 24 and and CC cord-006824-btcdjmfp 36 25 CD20 CD20 NNP cord-006824-btcdjmfp 36 26 with with IN cord-006824-btcdjmfp 36 27 complement complement JJ cord-006824-btcdjmfp 36 28 lysis lysis NN cord-006824-btcdjmfp 36 29 . . . cord-006824-btcdjmfp 37 1 An an DT cord-006824-btcdjmfp 37 2 intent intent NN cord-006824-btcdjmfp 37 3 - - HYPH cord-006824-btcdjmfp 37 4 to to IN cord-006824-btcdjmfp 37 5 - - HYPH cord-006824-btcdjmfp 37 6 treat treat VB cord-006824-btcdjmfp 37 7 analysis analysis NN cord-006824-btcdjmfp 37 8 is be VBZ cord-006824-btcdjmfp 37 9 shown show VBN cord-006824-btcdjmfp 37 10 in in IN cord-006824-btcdjmfp 37 11 Figure figure NN cord-006824-btcdjmfp 37 12 1 1 CD cord-006824-btcdjmfp 37 13 . . . cord-006824-btcdjmfp 38 1 At at IN cord-006824-btcdjmfp 38 2 the the DT cord-006824-btcdjmfp 38 3 time time NN cord-006824-btcdjmfp 38 4 of of IN cord-006824-btcdjmfp 38 5 analysis analysis NN cord-006824-btcdjmfp 38 6 , , , cord-006824-btcdjmfp 38 7 the the DT cord-006824-btcdjmfp 38 8 31 31 CD cord-006824-btcdjmfp 38 9 surviving survive VBG cord-006824-btcdjmfp 38 10 patients patient NNS cord-006824-btcdjmfp 38 11 had have VBD cord-006824-btcdjmfp 38 12 been be VBN cord-006824-btcdjmfp 38 13 followed follow VBN cord-006824-btcdjmfp 38 14 for for IN cord-006824-btcdjmfp 38 15 8 8 CD cord-006824-btcdjmfp 38 16 - - SYM cord-006824-btcdjmfp 38 17 14 14 CD cord-006824-btcdjmfp 38 18 years year NNS cord-006824-btcdjmfp 38 19 . . . cord-006824-btcdjmfp 39 1 Overall overall JJ cord-006824-btcdjmfp 39 2 survival survival NN cord-006824-btcdjmfp 39 3 was be VBD cord-006824-btcdjmfp 39 4 84 84 CD cord-006824-btcdjmfp 39 5 % % NN cord-006824-btcdjmfp 39 6 , , , cord-006824-btcdjmfp 39 7 event event NN cord-006824-btcdjmfp 39 8 - - HYPH cord-006824-btcdjmfp 39 9 free free JJ cord-006824-btcdjmfp 39 10 survival survival NN cord-006824-btcdjmfp 39 11 62 62 CD cord-006824-btcdjmfp 39 12 % % NN cord-006824-btcdjmfp 39 13 and and CC cord-006824-btcdjmfp 39 14 the the DT cord-006824-btcdjmfp 39 15 relapse relapse NN cord-006824-btcdjmfp 39 16 rate rate NN cord-006824-btcdjmfp 39 17 was be VBD cord-006824-btcdjmfp 39 18 29 29 CD cord-006824-btcdjmfp 39 19 % % NN cord-006824-btcdjmfp 39 20 . . . cord-006824-btcdjmfp 40 1 The the DT cord-006824-btcdjmfp 40 2 causes cause NNS cord-006824-btcdjmfp 40 3 for for IN cord-006824-btcdjmfp 40 4 treatment treatment NN cord-006824-btcdjmfp 40 5 failure failure NN cord-006824-btcdjmfp 40 6 included include VBD cord-006824-btcdjmfp 40 7 one one CD cord-006824-btcdjmfp 40 8 early early JJ cord-006824-btcdjmfp 40 9 death death NN cord-006824-btcdjmfp 40 10 due due IN cord-006824-btcdjmfp 40 11 to to IN cord-006824-btcdjmfp 40 12 septicemia septicemia NN cord-006824-btcdjmfp 40 13 , , , cord-006824-btcdjmfp 40 14 two two CD cord-006824-btcdjmfp 40 15 patients patient NNS cord-006824-btcdjmfp 40 16 died die VBD cord-006824-btcdjmfp 40 17 from from IN cord-006824-btcdjmfp 40 18 acute acute JJ cord-006824-btcdjmfp 40 19 leukemia leukemia NN cord-006824-btcdjmfp 40 20 and and CC cord-006824-btcdjmfp 40 21 three three CD cord-006824-btcdjmfp 40 22 patients patient NNS cord-006824-btcdjmfp 40 23 succumbed succumb VBD cord-006824-btcdjmfp 40 24 to to IN cord-006824-btcdjmfp 40 25 lymphoma lymphoma NN cord-006824-btcdjmfp 40 26 . . . cord-006824-btcdjmfp 41 1 The the DT cord-006824-btcdjmfp 41 2 excellent excellent JJ cord-006824-btcdjmfp 41 3 long long JJ cord-006824-btcdjmfp 41 4 - - HYPH cord-006824-btcdjmfp 41 5 term term NN cord-006824-btcdjmfp 41 6 survival survival NN cord-006824-btcdjmfp 41 7 demonstrated demonstrate VBN cord-006824-btcdjmfp 41 8 in in IN cord-006824-btcdjmfp 41 9 this this DT cord-006824-btcdjmfp 41 10 study study NN cord-006824-btcdjmfp 41 11 indicates indicate VBZ cord-006824-btcdjmfp 41 12 that that IN cord-006824-btcdjmfp 41 13 the the DT cord-006824-btcdjmfp 41 14 natural natural JJ cord-006824-btcdjmfp 41 15 course course NN cord-006824-btcdjmfp 41 16 of of IN cord-006824-btcdjmfp 41 17 the the DT cord-006824-btcdjmfp 41 18 underlying underlie VBG cord-006824-btcdjmfp 41 19 disease disease NN cord-006824-btcdjmfp 41 20 has have VBZ cord-006824-btcdjmfp 41 21 been be VBN cord-006824-btcdjmfp 41 22 markedly markedly RB cord-006824-btcdjmfp 41 23 altered alter VBN cord-006824-btcdjmfp 41 24 by by IN cord-006824-btcdjmfp 41 25 the the DT cord-006824-btcdjmfp 41 26 autologous autologous JJ cord-006824-btcdjmfp 41 27 HCT HCT NNP cord-006824-btcdjmfp 41 28 approach approach NN cord-006824-btcdjmfp 41 29 . . . cord-006824-btcdjmfp 42 1 A a DT cord-006824-btcdjmfp 42 2 case case NN cord-006824-btcdjmfp 42 3 - - HYPH cord-006824-btcdjmfp 42 4 matched match VBN cord-006824-btcdjmfp 42 5 comparison comparison NN cord-006824-btcdjmfp 42 6 from from IN cord-006824-btcdjmfp 42 7 the the DT cord-006824-btcdjmfp 42 8 Stanford Stanford NNP cord-006824-btcdjmfp 42 9 NHL NHL NNP cord-006824-btcdjmfp 42 10 data data NN cord-006824-btcdjmfp 42 11 base base NN cord-006824-btcdjmfp 42 12 indicates indicate VBZ cord-006824-btcdjmfp 42 13 a a DT cord-006824-btcdjmfp 42 14 significant significant JJ cord-006824-btcdjmfp 42 15 survival survival NN cord-006824-btcdjmfp 42 16 advantage advantage NN cord-006824-btcdjmfp 42 17 compared compare VBN cord-006824-btcdjmfp 42 18 to to IN cord-006824-btcdjmfp 42 19 patients patient NNS cord-006824-btcdjmfp 42 20 not not RB cord-006824-btcdjmfp 42 21 undergoing undergo VBG cord-006824-btcdjmfp 42 22 transplantation transplantation NN cord-006824-btcdjmfp 42 23 . . . cord-006824-btcdjmfp 43 1 Conversely conversely RB cord-006824-btcdjmfp 43 2 , , , cord-006824-btcdjmfp 43 3 patients patient NNS cord-006824-btcdjmfp 43 4 with with IN cord-006824-btcdjmfp 43 5 follicular follicular JJ cord-006824-btcdjmfp 43 6 lymphoma lymphoma NN cord-006824-btcdjmfp 43 7 who who WP cord-006824-btcdjmfp 43 8 proceed proceed VBP cord-006824-btcdjmfp 43 9 to to IN cord-006824-btcdjmfp 43 10 transplantation transplantation NN cord-006824-btcdjmfp 43 11 have have VBP cord-006824-btcdjmfp 43 12 a a DT cord-006824-btcdjmfp 43 13 reduced reduce VBN cord-006824-btcdjmfp 43 14 chance chance NN cord-006824-btcdjmfp 43 15 for for IN cord-006824-btcdjmfp 43 16 long long JJ cord-006824-btcdjmfp 43 17 - - HYPH cord-006824-btcdjmfp 43 18 term term NN cord-006824-btcdjmfp 43 19 survival survival NN cord-006824-btcdjmfp 43 20 . . . cord-006824-btcdjmfp 44 1 Four four CD cord-006824-btcdjmfp 44 2 groups group NNS cord-006824-btcdjmfp 44 3 of of IN cord-006824-btcdjmfp 44 4 investigators investigator NNS cord-006824-btcdjmfp 44 5 at at IN cord-006824-btcdjmfp 44 6 Boston Boston NNP cord-006824-btcdjmfp 44 7 , , , cord-006824-btcdjmfp 44 8 London London NNP cord-006824-btcdjmfp 44 9 , , , cord-006824-btcdjmfp 44 10 Omaha Omaha NNP cord-006824-btcdjmfp 44 11 and and CC cord-006824-btcdjmfp 44 12 Stanford Stanford NNP cord-006824-btcdjmfp 44 13 have have VBP cord-006824-btcdjmfp 44 14 evaluated evaluate VBN cord-006824-btcdjmfp 44 15 360 360 CD cord-006824-btcdjmfp 44 16 autologous autologous JJ cord-006824-btcdjmfp 44 17 HCT hct NN cord-006824-btcdjmfp 44 18 recipients recipient NNS cord-006824-btcdjmfp 44 19 in in IN cord-006824-btcdjmfp 44 20 four four CD cord-006824-btcdjmfp 44 21 independent independent JJ cord-006824-btcdjmfp 44 22 trials trial NNS cord-006824-btcdjmfp 44 23 . . . cord-006824-btcdjmfp 45 1 Four four CD cord-006824-btcdjmfp 45 2 to to TO cord-006824-btcdjmfp 45 3 eight eight CD cord-006824-btcdjmfp 45 4 years year NNS cord-006824-btcdjmfp 45 5 following follow VBG cord-006824-btcdjmfp 45 6 autologous autologous JJ cord-006824-btcdjmfp 45 7 HCT hct NN cord-006824-btcdjmfp 45 8 , , , cord-006824-btcdjmfp 45 9 overall overall JJ cord-006824-btcdjmfp 45 10 survival survival NN cord-006824-btcdjmfp 45 11 ranged range VBD cord-006824-btcdjmfp 45 12 from from IN cord-006824-btcdjmfp 45 13 60 60 CD cord-006824-btcdjmfp 45 14 - - SYM cord-006824-btcdjmfp 45 15 69 69 CD cord-006824-btcdjmfp 45 16 % % NN cord-006824-btcdjmfp 45 17 and and CC cord-006824-btcdjmfp 45 18 freedom freedom NN cord-006824-btcdjmfp 45 19 from from IN cord-006824-btcdjmfp 45 20 relapse relapse NN cord-006824-btcdjmfp 45 21 ranged range VBD cord-006824-btcdjmfp 45 22 from from IN cord-006824-btcdjmfp 45 23 42 42 CD cord-006824-btcdjmfp 45 24 - - SYM cord-006824-btcdjmfp 45 25 63 63 CD cord-006824-btcdjmfp 45 26 % % NN cord-006824-btcdjmfp 45 27 . . . cord-006824-btcdjmfp 46 1 The the DT cord-006824-btcdjmfp 46 2 event event NN cord-006824-btcdjmfp 46 3 of of IN cord-006824-btcdjmfp 46 4 a a DT cord-006824-btcdjmfp 46 5 relapse relapse NN cord-006824-btcdjmfp 46 6 of of IN cord-006824-btcdjmfp 46 7 follicular follicular JJ cord-006824-btcdjmfp 46 8 NHL NHL NNP cord-006824-btcdjmfp 46 9 clearly clearly RB cord-006824-btcdjmfp 46 10 reduces reduce VBZ cord-006824-btcdjmfp 46 11 the the DT cord-006824-btcdjmfp 46 12 chance chance NN cord-006824-btcdjmfp 46 13 for for IN cord-006824-btcdjmfp 46 14 disease disease NN cord-006824-btcdjmfp 46 15 - - HYPH cord-006824-btcdjmfp 46 16 free free JJ cord-006824-btcdjmfp 46 17 survival survival NN cord-006824-btcdjmfp 46 18 . . . cord-006824-btcdjmfp 47 1 A a DT cord-006824-btcdjmfp 47 2 prospective prospective JJ cord-006824-btcdjmfp 47 3 clinical clinical JJ cord-006824-btcdjmfp 47 4 trial trial NN cord-006824-btcdjmfp 47 5 in in IN cord-006824-btcdjmfp 47 6 follicular follicular JJ cord-006824-btcdjmfp 47 7 lymphoma lymphoma NN cord-006824-btcdjmfp 47 8 has have VBZ cord-006824-btcdjmfp 47 9 been be VBN cord-006824-btcdjmfp 47 10 completed complete VBN cord-006824-btcdjmfp 47 11 recently recently RB cord-006824-btcdjmfp 47 12 in in IN cord-006824-btcdjmfp 47 13 Europe Europe NNP cord-006824-btcdjmfp 47 14 . . . cord-006824-btcdjmfp 48 1 In in IN cord-006824-btcdjmfp 48 2 this this DT cord-006824-btcdjmfp 48 3 study study NN cord-006824-btcdjmfp 48 4 , , , cord-006824-btcdjmfp 48 5 patients patient NNS cord-006824-btcdjmfp 48 6 with with IN cord-006824-btcdjmfp 48 7 this this DT cord-006824-btcdjmfp 48 8 type type NN cord-006824-btcdjmfp 48 9 of of IN cord-006824-btcdjmfp 48 10 lymphoma lymphoma NN cord-006824-btcdjmfp 48 11 were be VBD cord-006824-btcdjmfp 48 12 treated treat VBN cord-006824-btcdjmfp 48 13 with with IN cord-006824-btcdjmfp 48 14 cytoreductive cytoreductive JJ cord-006824-btcdjmfp 48 15 therapy therapy NN cord-006824-btcdjmfp 48 16 to to IN cord-006824-btcdjmfp 48 17 minimal minimal JJ cord-006824-btcdjmfp 48 18 disease disease NN cord-006824-btcdjmfp 48 19 and and CC cord-006824-btcdjmfp 48 20 were be VBD cord-006824-btcdjmfp 48 21 then then RB cord-006824-btcdjmfp 48 22 randomized randomize VBN cord-006824-btcdjmfp 48 23 to to TO cord-006824-btcdjmfp 48 24 receive receive VB cord-006824-btcdjmfp 48 25 either either CC cord-006824-btcdjmfp 48 26 high high JJ cord-006824-btcdjmfp 48 27 dose dose NN cord-006824-btcdjmfp 48 28 radiochemotherapy radiochemotherapy NN cord-006824-btcdjmfp 48 29 and and CC cord-006824-btcdjmfp 48 30 autologous autologous JJ cord-006824-btcdjmfp 48 31 HCT hct NN cord-006824-btcdjmfp 48 32 or or CC cord-006824-btcdjmfp 48 33 interferon interferon NN cord-006824-btcdjmfp 48 34 . . . cord-006824-btcdjmfp 49 1 The the DT cord-006824-btcdjmfp 49 2 data datum NNS cord-006824-btcdjmfp 49 3 of of IN cord-006824-btcdjmfp 49 4 this this DT cord-006824-btcdjmfp 49 5 trial trial NN cord-006824-btcdjmfp 49 6 are be VBP cord-006824-btcdjmfp 49 7 currently currently RB cord-006824-btcdjmfp 49 8 being be VBG cord-006824-btcdjmfp 49 9 prepared prepare VBN cord-006824-btcdjmfp 49 10 for for IN cord-006824-btcdjmfp 49 11 publication publication NN cord-006824-btcdjmfp 49 12 . . . cord-006824-btcdjmfp 50 1 A a DT cord-006824-btcdjmfp 50 2 preliminary preliminary JJ cord-006824-btcdjmfp 50 3 review review NN cord-006824-btcdjmfp 50 4 indicates indicate VBZ cord-006824-btcdjmfp 50 5 a a DT cord-006824-btcdjmfp 50 6 statistical statistical JJ cord-006824-btcdjmfp 50 7 advantage advantage NN cord-006824-btcdjmfp 50 8 in in IN cord-006824-btcdjmfp 50 9 progression progression NN cord-006824-btcdjmfp 50 10 - - HYPH cord-006824-btcdjmfp 50 11 free free JJ cord-006824-btcdjmfp 50 12 survival survival NN cord-006824-btcdjmfp 50 13 in in IN cord-006824-btcdjmfp 50 14 favor favor NN cord-006824-btcdjmfp 50 15 of of IN cord-006824-btcdjmfp 50 16 transplantation transplantation NN cord-006824-btcdjmfp 50 17 ( ( -LRB- cord-006824-btcdjmfp 50 18 W. W. NNP cord-006824-btcdjmfp 50 19 Hiddemann Hiddemann NNP cord-006824-btcdjmfp 50 20 , , , cord-006824-btcdjmfp 50 21 personal personal JJ cord-006824-btcdjmfp 50 22 communication communication NN cord-006824-btcdjmfp 50 23 , , , cord-006824-btcdjmfp 50 24 2002 2002 CD cord-006824-btcdjmfp 50 25 ) ) -RRB- cord-006824-btcdjmfp 50 26 . . . cord-006824-btcdjmfp 51 1 Other other JJ cord-006824-btcdjmfp 51 2 efforts effort NNS cord-006824-btcdjmfp 51 3 to to TO cord-006824-btcdjmfp 51 4 overcome overcome VB cord-006824-btcdjmfp 51 5 the the DT cord-006824-btcdjmfp 51 6 relapse relapse NN cord-006824-btcdjmfp 51 7 problem problem NN cord-006824-btcdjmfp 51 8 include include VBP cord-006824-btcdjmfp 51 9 the the DT cord-006824-btcdjmfp 51 10 use use NN cord-006824-btcdjmfp 51 11 of of IN cord-006824-btcdjmfp 51 12 maximum maximum JJ cord-006824-btcdjmfp 51 13 tolerated tolerate VBN cord-006824-btcdjmfp 51 14 regimens regimen NNS cord-006824-btcdjmfp 51 15 with with IN cord-006824-btcdjmfp 51 16 or or CC cord-006824-btcdjmfp 51 17 without without IN cord-006824-btcdjmfp 51 18 total total JJ cord-006824-btcdjmfp 51 19 body body NN cord-006824-btcdjmfp 51 20 irradiation irradiation NN cord-006824-btcdjmfp 51 21 . . . cord-006824-btcdjmfp 52 1 More more RBR cord-006824-btcdjmfp 52 2 recently recently RB cord-006824-btcdjmfp 52 3 , , , cord-006824-btcdjmfp 52 4 radiolabeled radiolabele VBN cord-006824-btcdjmfp 52 5 monoclonal monoclonal JJ cord-006824-btcdjmfp 52 6 antibodies antibody NNS cord-006824-btcdjmfp 52 7 have have VBP cord-006824-btcdjmfp 52 8 been be VBN cord-006824-btcdjmfp 52 9 introduced introduce VBN cord-006824-btcdjmfp 52 10 and and CC cord-006824-btcdjmfp 52 11 these these DT cord-006824-btcdjmfp 52 12 interesting interesting JJ cord-006824-btcdjmfp 52 13 efforts effort NNS cord-006824-btcdjmfp 52 14 have have VBP cord-006824-btcdjmfp 52 15 yielded yield VBN cord-006824-btcdjmfp 52 16 promising promising JJ cord-006824-btcdjmfp 52 17 results result NNS cord-006824-btcdjmfp 52 18 [ [ -LRB- cord-006824-btcdjmfp 52 19 7 7 CD cord-006824-btcdjmfp 52 20 ] ] -RRB- cord-006824-btcdjmfp 52 21 . . . cord-006824-btcdjmfp 53 1 Another another DT cord-006824-btcdjmfp 53 2 approach approach NN cord-006824-btcdjmfp 53 3 to to TO cord-006824-btcdjmfp 53 4 reduce reduce VB cord-006824-btcdjmfp 53 5 the the DT cord-006824-btcdjmfp 53 6 post post JJ cord-006824-btcdjmfp 53 7 - - JJ cord-006824-btcdjmfp 53 8 transplant transplant JJ cord-006824-btcdjmfp 53 9 relapse relapse NN cord-006824-btcdjmfp 53 10 rate rate NN cord-006824-btcdjmfp 53 11 is be VBZ cord-006824-btcdjmfp 53 12 the the DT cord-006824-btcdjmfp 53 13 employment employment NN cord-006824-btcdjmfp 53 14 of of IN cord-006824-btcdjmfp 53 15 monoclonal monoclonal JJ cord-006824-btcdjmfp 53 16 antibodies antibody NNS cord-006824-btcdjmfp 53 17 directed direct VBN cord-006824-btcdjmfp 53 18 against against IN cord-006824-btcdjmfp 53 19 epitopes epitope NNS cord-006824-btcdjmfp 53 20 expressed express VBN cord-006824-btcdjmfp 53 21 on on IN cord-006824-btcdjmfp 53 22 lymphoma lymphoma NN cord-006824-btcdjmfp 53 23 cells cell NNS cord-006824-btcdjmfp 53 24 . . . cord-006824-btcdjmfp 54 1 In in IN cord-006824-btcdjmfp 54 2 an an DT cord-006824-btcdjmfp 54 3 exploratory exploratory JJ cord-006824-btcdjmfp 54 4 trial trial NN cord-006824-btcdjmfp 54 5 , , , cord-006824-btcdjmfp 54 6 we -PRON- PRP cord-006824-btcdjmfp 54 7 have have VBP cord-006824-btcdjmfp 54 8 administered administer VBN cord-006824-btcdjmfp 54 9 the the DT cord-006824-btcdjmfp 54 10 antibody antibody NN cord-006824-btcdjmfp 54 11 directed direct VBN cord-006824-btcdjmfp 54 12 against against IN cord-006824-btcdjmfp 54 13 the the DT cord-006824-btcdjmfp 54 14 CD20 CD20 NNP cord-006824-btcdjmfp 54 15 epitope epitope NN cord-006824-btcdjmfp 54 16 to to IN cord-006824-btcdjmfp 54 17 35 35 CD cord-006824-btcdjmfp 54 18 autologous autologous JJ cord-006824-btcdjmfp 54 19 HCT HCT NNP cord-006824-btcdjmfp 54 20 recipients recipient NNS cord-006824-btcdjmfp 54 21 whose whose WP$ cord-006824-btcdjmfp 54 22 lymphoma lymphoma NN cord-006824-btcdjmfp 54 23 cells cell NNS cord-006824-btcdjmfp 54 24 expressed express VBD cord-006824-btcdjmfp 54 25 CD20 CD20 NNP cord-006824-btcdjmfp 54 26 [ [ -LRB- cord-006824-btcdjmfp 54 27 8 8 CD cord-006824-btcdjmfp 54 28 ] ] -RRB- cord-006824-btcdjmfp 54 29 . . . cord-006824-btcdjmfp 55 1 These these DT cord-006824-btcdjmfp 55 2 35 35 CD cord-006824-btcdjmfp 55 3 patients patient NNS cord-006824-btcdjmfp 55 4 had have VBD cord-006824-btcdjmfp 55 5 a a DT cord-006824-btcdjmfp 55 6 median median JJ cord-006824-btcdjmfp 55 7 age age NN cord-006824-btcdjmfp 55 8 of of IN cord-006824-btcdjmfp 55 9 51 51 CD cord-006824-btcdjmfp 55 10 years year NNS cord-006824-btcdjmfp 55 11 ranging range VBG cord-006824-btcdjmfp 55 12 from from IN cord-006824-btcdjmfp 55 13 28 28 CD cord-006824-btcdjmfp 55 14 to to TO cord-006824-btcdjmfp 55 15 70 70 CD cord-006824-btcdjmfp 55 16 years year NNS cord-006824-btcdjmfp 55 17 . . . cord-006824-btcdjmfp 56 1 Following follow VBG cord-006824-btcdjmfp 56 2 our -PRON- PRP$ cord-006824-btcdjmfp 56 3 standardized standardized JJ cord-006824-btcdjmfp 56 4 transplant transplant NN cord-006824-btcdjmfp 56 5 approach approach NN cord-006824-btcdjmfp 56 6 , , , cord-006824-btcdjmfp 56 7 an an DT cord-006824-btcdjmfp 56 8 intent intent NN cord-006824-btcdjmfp 56 9 - - HYPH cord-006824-btcdjmfp 56 10 to to IN cord-006824-btcdjmfp 56 11 - - HYPH cord-006824-btcdjmfp 56 12 treat treat VB cord-006824-btcdjmfp 56 13 analysis analysis NN cord-006824-btcdjmfp 56 14 shows show VBZ cord-006824-btcdjmfp 56 15 that that IN cord-006824-btcdjmfp 56 16 31 31 CD cord-006824-btcdjmfp 56 17 of of IN cord-006824-btcdjmfp 56 18 35 35 CD cord-006824-btcdjmfp 56 19 patients patient NNS cord-006824-btcdjmfp 56 20 are be VBP cord-006824-btcdjmfp 56 21 alive alive JJ cord-006824-btcdjmfp 56 22 and and CC cord-006824-btcdjmfp 56 23 29 29 CD cord-006824-btcdjmfp 56 24 are be VBP cord-006824-btcdjmfp 56 25 in in IN cord-006824-btcdjmfp 56 26 continued continue VBN cord-006824-btcdjmfp 56 27 complete complete JJ cord-006824-btcdjmfp 56 28 remission remission NN cord-006824-btcdjmfp 56 29 with with IN cord-006824-btcdjmfp 56 30 a a DT cord-006824-btcdjmfp 56 31 follow follow NN cord-006824-btcdjmfp 56 32 - - HYPH cord-006824-btcdjmfp 56 33 up up RP cord-006824-btcdjmfp 56 34 period period NN cord-006824-btcdjmfp 56 35 ranging range VBG cord-006824-btcdjmfp 56 36 from from IN cord-006824-btcdjmfp 56 37 1.3 1.3 CD cord-006824-btcdjmfp 56 38 to to IN cord-006824-btcdjmfp 56 39 4.1 4.1 CD cord-006824-btcdjmfp 56 40 years year NNS cord-006824-btcdjmfp 56 41 . . . cord-006824-btcdjmfp 57 1 A a DT cord-006824-btcdjmfp 57 2 comparison comparison NN cord-006824-btcdjmfp 57 3 with with IN cord-006824-btcdjmfp 57 4 similar similar JJ cord-006824-btcdjmfp 57 5 autologous autologous JJ cord-006824-btcdjmfp 57 6 HCT hct NN cord-006824-btcdjmfp 57 7 recipients recipient NNS cord-006824-btcdjmfp 57 8 with with IN cord-006824-btcdjmfp 57 9 NHL NHL NNP cord-006824-btcdjmfp 57 10 who who WP cord-006824-btcdjmfp 57 11 had have VBD cord-006824-btcdjmfp 57 12 not not RB cord-006824-btcdjmfp 57 13 been be VBN cord-006824-btcdjmfp 57 14 treated treat VBN cord-006824-btcdjmfp 57 15 with with IN cord-006824-btcdjmfp 57 16 the the DT cord-006824-btcdjmfp 57 17 monoclonal monoclonal JJ cord-006824-btcdjmfp 57 18 antibody antibody NN cord-006824-btcdjmfp 57 19 after after IN cord-006824-btcdjmfp 57 20 transplantation transplantation NN cord-006824-btcdjmfp 57 21 indicates indicate VBZ cord-006824-btcdjmfp 57 22 that that IN cord-006824-btcdjmfp 57 23 Figure figure NN cord-006824-btcdjmfp 57 24 1 1 CD cord-006824-btcdjmfp 57 25 : : : cord-006824-btcdjmfp 57 26 Overall overall JJ cord-006824-btcdjmfp 57 27 survival survival NN cord-006824-btcdjmfp 57 28 , , , cord-006824-btcdjmfp 57 29 event event NN cord-006824-btcdjmfp 57 30 - - HYPH cord-006824-btcdjmfp 57 31 free free JJ cord-006824-btcdjmfp 57 32 survival survival NN cord-006824-btcdjmfp 57 33 and and CC cord-006824-btcdjmfp 57 34 relapse relapse NN cord-006824-btcdjmfp 57 35 following follow VBG cord-006824-btcdjmfp 57 36 autologous autologous JJ cord-006824-btcdjmfp 57 37 bone bone NN cord-006824-btcdjmfp 57 38 marrow marrow NN cord-006824-btcdjmfp 57 39 transplantation transplantation NN cord-006824-btcdjmfp 57 40 in in IN cord-006824-btcdjmfp 57 41 37 37 CD cord-006824-btcdjmfp 57 42 patients patient NNS cord-006824-btcdjmfp 57 43 with with IN cord-006824-btcdjmfp 57 44 follicular follicular JJ cord-006824-btcdjmfp 57 45 lymphoma lymphoma NN cord-006824-btcdjmfp 57 46 during during IN cord-006824-btcdjmfp 57 47 their -PRON- PRP$ cord-006824-btcdjmfp 57 48 first first JJ cord-006824-btcdjmfp 57 49 complete complete JJ cord-006824-btcdjmfp 57 50 or or CC cord-006824-btcdjmfp 57 51 first first JJ cord-006824-btcdjmfp 57 52 partial partial JJ cord-006824-btcdjmfp 57 53 chemotherapy chemotherapy NN cord-006824-btcdjmfp 57 54 - - HYPH cord-006824-btcdjmfp 57 55 induced induce VBN cord-006824-btcdjmfp 57 56 remissions remission NNS cord-006824-btcdjmfp 57 57 this this DT cord-006824-btcdjmfp 57 58 new new JJ cord-006824-btcdjmfp 57 59 post post JJ cord-006824-btcdjmfp 57 60 - - JJ cord-006824-btcdjmfp 57 61 transplant transplant NN cord-006824-btcdjmfp 57 62 therapy therapy NN cord-006824-btcdjmfp 57 63 has have VBZ cord-006824-btcdjmfp 57 64 contributed contribute VBN cord-006824-btcdjmfp 57 65 positively positively RB cord-006824-btcdjmfp 57 66 to to IN cord-006824-btcdjmfp 57 67 the the DT cord-006824-btcdjmfp 57 68 treatment treatment NN cord-006824-btcdjmfp 57 69 outcome outcome NN cord-006824-btcdjmfp 57 70 . . . cord-006824-btcdjmfp 58 1 Clearly clearly RB cord-006824-btcdjmfp 58 2 , , , cord-006824-btcdjmfp 58 3 a a DT cord-006824-btcdjmfp 58 4 prospective prospective JJ cord-006824-btcdjmfp 58 5 randomized randomized JJ cord-006824-btcdjmfp 58 6 study study NN cord-006824-btcdjmfp 58 7 is be VBZ cord-006824-btcdjmfp 58 8 needed need VBN cord-006824-btcdjmfp 58 9 to to TO cord-006824-btcdjmfp 58 10 confirm confirm VB cord-006824-btcdjmfp 58 11 our -PRON- PRP$ cord-006824-btcdjmfp 58 12 promising promising JJ cord-006824-btcdjmfp 58 13 observation observation NN cord-006824-btcdjmfp 58 14 . . . cord-006824-btcdjmfp 59 1 Such such JJ cord-006824-btcdjmfp 59 2 a a DT cord-006824-btcdjmfp 59 3 trial trial NN cord-006824-btcdjmfp 59 4 is be VBZ cord-006824-btcdjmfp 59 5 being be VBG cord-006824-btcdjmfp 59 6 performed perform VBN cord-006824-btcdjmfp 59 7 under under IN cord-006824-btcdjmfp 59 8 the the DT cord-006824-btcdjmfp 59 9 auspices auspex NNS cord-006824-btcdjmfp 59 10 of of IN cord-006824-btcdjmfp 59 11 the the DT cord-006824-btcdjmfp 59 12 Eastern Eastern NNP cord-006824-btcdjmfp 59 13 Oncology Oncology NNP cord-006824-btcdjmfp 59 14 Group Group NNP cord-006824-btcdjmfp 59 15 ( ( -LRB- cord-006824-btcdjmfp 59 16 ECOG ECOG NNP cord-006824-btcdjmfp 59 17 Trial Trial NNP cord-006824-btcdjmfp 59 18 2199 2199 CD cord-006824-btcdjmfp 59 19 ) ) -RRB- cord-006824-btcdjmfp 59 20 . . . cord-006824-btcdjmfp 60 1 In in IN cord-006824-btcdjmfp 60 2 1986 1986 CD cord-006824-btcdjmfp 60 3 , , , cord-006824-btcdjmfp 60 4 a a DT cord-006824-btcdjmfp 60 5 first first JJ cord-006824-btcdjmfp 60 6 group group NN cord-006824-btcdjmfp 60 7 of of IN cord-006824-btcdjmfp 60 8 17 17 CD cord-006824-btcdjmfp 60 9 patients patient NNS cord-006824-btcdjmfp 60 10 ( ( -LRB- cord-006824-btcdjmfp 60 11 14 14 CD cord-006824-btcdjmfp 60 12 with with IN cord-006824-btcdjmfp 60 13 NHL NHL NNP cord-006824-btcdjmfp 60 14 and and CC cord-006824-btcdjmfp 60 15 three three CD cord-006824-btcdjmfp 60 16 with with IN cord-006824-btcdjmfp 60 17 Hodgkin Hodgkin NNP cord-006824-btcdjmfp 60 18 's 's POS cord-006824-btcdjmfp 60 19 disease disease NN cord-006824-btcdjmfp 60 20 ) ) -RRB- cord-006824-btcdjmfp 60 21 was be VBD cord-006824-btcdjmfp 60 22 described describe VBN cord-006824-btcdjmfp 60 23 indicating indicate VBG cord-006824-btcdjmfp 60 24 that that IN cord-006824-btcdjmfp 60 25 extended extended JJ cord-006824-btcdjmfp 60 26 disease disease NN cord-006824-btcdjmfp 60 27 - - HYPH cord-006824-btcdjmfp 60 28 free free JJ cord-006824-btcdjmfp 60 29 long long JJ cord-006824-btcdjmfp 60 30 - - HYPH cord-006824-btcdjmfp 60 31 term term NN cord-006824-btcdjmfp 60 32 survival survival NN cord-006824-btcdjmfp 60 33 can can MD cord-006824-btcdjmfp 60 34 be be VB cord-006824-btcdjmfp 60 35 attained attain VBN cord-006824-btcdjmfp 60 36 with with IN cord-006824-btcdjmfp 60 37 high high JJ cord-006824-btcdjmfp 60 38 dose dose NN cord-006824-btcdjmfp 60 39 therapy therapy NN cord-006824-btcdjmfp 60 40 followed follow VBN cord-006824-btcdjmfp 60 41 by by IN cord-006824-btcdjmfp 60 42 allogeneic allogeneic NN cord-006824-btcdjmfp 60 43 transplantation transplantation NN cord-006824-btcdjmfp 60 44 utilizing utilize VBG cord-006824-btcdjmfp 60 45 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 60 46 cells cell NNS cord-006824-btcdjmfp 60 47 obtained obtain VBN cord-006824-btcdjmfp 60 48 either either CC cord-006824-btcdjmfp 60 49 from from IN cord-006824-btcdjmfp 60 50 fully fully RB cord-006824-btcdjmfp 60 51 or or CC cord-006824-btcdjmfp 60 52 closely closely RB cord-006824-btcdjmfp 60 53 matched match VBN cord-006824-btcdjmfp 60 54 related related JJ cord-006824-btcdjmfp 60 55 donors donor NNS cord-006824-btcdjmfp 60 56 [ [ -LRB- cord-006824-btcdjmfp 60 57 9 9 CD cord-006824-btcdjmfp 60 58 ] ] -RRB- cord-006824-btcdjmfp 60 59 . . . cord-006824-btcdjmfp 61 1 The the DT cord-006824-btcdjmfp 61 2 treatment treatment NN cord-006824-btcdjmfp 61 3 outcome outcome NN cord-006824-btcdjmfp 61 4 was be VBD cord-006824-btcdjmfp 61 5 greatly greatly RB cord-006824-btcdjmfp 61 6 influenced influence VBN cord-006824-btcdjmfp 61 7 by by IN cord-006824-btcdjmfp 61 8 the the DT cord-006824-btcdjmfp 61 9 remission remission NN cord-006824-btcdjmfp 61 10 status status NN cord-006824-btcdjmfp 61 11 of of IN cord-006824-btcdjmfp 61 12 the the DT cord-006824-btcdjmfp 61 13 transplant transplant NN cord-006824-btcdjmfp 61 14 recipient recipient NN cord-006824-btcdjmfp 61 15 at at IN cord-006824-btcdjmfp 61 16 the the DT cord-006824-btcdjmfp 61 17 time time NN cord-006824-btcdjmfp 61 18 when when WRB cord-006824-btcdjmfp 61 19 preparation preparation NN cord-006824-btcdjmfp 61 20 for for IN cord-006824-btcdjmfp 61 21 transplantation transplantation NN cord-006824-btcdjmfp 61 22 was be VBD cord-006824-btcdjmfp 61 23 begun begin VBN cord-006824-btcdjmfp 61 24 , , , cord-006824-btcdjmfp 61 25 age age NN cord-006824-btcdjmfp 61 26 of of IN cord-006824-btcdjmfp 61 27 the the DT cord-006824-btcdjmfp 61 28 recipient recipient NN cord-006824-btcdjmfp 61 29 , , , cord-006824-btcdjmfp 61 30 compatibility compatibility NN cord-006824-btcdjmfp 61 31 with with IN cord-006824-btcdjmfp 61 32 the the DT cord-006824-btcdjmfp 61 33 respective respective JJ cord-006824-btcdjmfp 61 34 donor donor NN cord-006824-btcdjmfp 61 35 and and CC cord-006824-btcdjmfp 61 36 incidence incidence NN cord-006824-btcdjmfp 61 37 of of IN cord-006824-btcdjmfp 61 38 post post JJ cord-006824-btcdjmfp 61 39 - - JJ cord-006824-btcdjmfp 61 40 transplant transplant JJ cord-006824-btcdjmfp 61 41 complications complication NNS cord-006824-btcdjmfp 61 42 . . . cord-006824-btcdjmfp 62 1 The the DT cord-006824-btcdjmfp 62 2 leading leading JJ cord-006824-btcdjmfp 62 3 cause cause NN cord-006824-btcdjmfp 62 4 for for IN cord-006824-btcdjmfp 62 5 treatment treatment NN cord-006824-btcdjmfp 62 6 failure failure NN cord-006824-btcdjmfp 62 7 remains remain VBZ cord-006824-btcdjmfp 62 8 graft graft NN cord-006824-btcdjmfp 62 9 - - HYPH cord-006824-btcdjmfp 62 10 versus versus IN cord-006824-btcdjmfp 62 11 - - HYPH cord-006824-btcdjmfp 62 12 host host NN cord-006824-btcdjmfp 62 13 disease disease NN cord-006824-btcdjmfp 62 14 ( ( -LRB- cord-006824-btcdjmfp 62 15 GVHD GVHD NNP cord-006824-btcdjmfp 62 16 ) ) -RRB- cord-006824-btcdjmfp 62 17 with with IN cord-006824-btcdjmfp 62 18 associated associated JJ cord-006824-btcdjmfp 62 19 infectious infectious JJ cord-006824-btcdjmfp 62 20 complications complication NNS cord-006824-btcdjmfp 62 21 , , , cord-006824-btcdjmfp 62 22 other other JJ cord-006824-btcdjmfp 62 23 toxicities toxicity NNS cord-006824-btcdjmfp 62 24 or or CC cord-006824-btcdjmfp 62 25 relapse relapse NN cord-006824-btcdjmfp 62 26 of of IN cord-006824-btcdjmfp 62 27 the the DT cord-006824-btcdjmfp 62 28 underlying underlie VBG cord-006824-btcdjmfp 62 29 disease disease NN cord-006824-btcdjmfp 62 30 . . . cord-006824-btcdjmfp 63 1 Figure figure NN cord-006824-btcdjmfp 63 2 2 2 CD cord-006824-btcdjmfp 63 3 illustrates illustrate VBZ cord-006824-btcdjmfp 63 4 our -PRON- PRP$ cord-006824-btcdjmfp 63 5 institutional institutional JJ cord-006824-btcdjmfp 63 6 experience experience NN cord-006824-btcdjmfp 63 7 with with IN cord-006824-btcdjmfp 63 8 36 36 CD cord-006824-btcdjmfp 63 9 patients patient NNS cord-006824-btcdjmfp 63 10 ( ( -LRB- cord-006824-btcdjmfp 63 11 seven seven CD cord-006824-btcdjmfp 63 12 children child NNS cord-006824-btcdjmfp 63 13 / / SYM cord-006824-btcdjmfp 63 14 adolescents adolescent NNS cord-006824-btcdjmfp 63 15 and and CC cord-006824-btcdjmfp 63 16 29 29 CD cord-006824-btcdjmfp 63 17 adults adult NNS cord-006824-btcdjmfp 63 18 ) ) -RRB- cord-006824-btcdjmfp 63 19 . . . cord-006824-btcdjmfp 64 1 The the DT cord-006824-btcdjmfp 64 2 median median JJ cord-006824-btcdjmfp 64 3 age age NN cord-006824-btcdjmfp 64 4 of of IN cord-006824-btcdjmfp 64 5 the the DT cord-006824-btcdjmfp 64 6 patient patient JJ cord-006824-btcdjmfp 64 7 population population NN cord-006824-btcdjmfp 64 8 was be VBD cord-006824-btcdjmfp 64 9 35 35 CD cord-006824-btcdjmfp 64 10 years year NNS cord-006824-btcdjmfp 64 11 ranging range VBG cord-006824-btcdjmfp 64 12 from from IN cord-006824-btcdjmfp 64 13 5 5 CD cord-006824-btcdjmfp 64 14 to to TO cord-006824-btcdjmfp 64 15 60 60 CD cord-006824-btcdjmfp 64 16 years year NNS cord-006824-btcdjmfp 64 17 . . . cord-006824-btcdjmfp 65 1 Median median JJ cord-006824-btcdjmfp 65 2 follow follow NN cord-006824-btcdjmfp 65 3 - - HYPH cord-006824-btcdjmfp 65 4 up up NN cord-006824-btcdjmfp 65 5 in in IN cord-006824-btcdjmfp 65 6 continued continued JJ cord-006824-btcdjmfp 65 7 complete complete JJ cord-006824-btcdjmfp 65 8 remission remission NN cord-006824-btcdjmfp 65 9 of of IN cord-006824-btcdjmfp 65 10 survivors survivor NNS cord-006824-btcdjmfp 65 11 is be VBZ cord-006824-btcdjmfp 65 12 in in IN cord-006824-btcdjmfp 65 13 excess excess NN cord-006824-btcdjmfp 65 14 of of IN cord-006824-btcdjmfp 65 15 six six CD cord-006824-btcdjmfp 65 16 years year NNS cord-006824-btcdjmfp 65 17 ranging range VBG cord-006824-btcdjmfp 65 18 from from IN cord-006824-btcdjmfp 65 19 six six CD cord-006824-btcdjmfp 65 20 months month NNS cord-006824-btcdjmfp 65 21 to to IN cord-006824-btcdjmfp 65 22 more more JJR cord-006824-btcdjmfp 65 23 than than IN cord-006824-btcdjmfp 65 24 10 10 CD cord-006824-btcdjmfp 65 25 years year NNS cord-006824-btcdjmfp 65 26 . . . cord-006824-btcdjmfp 66 1 Overall overall JJ cord-006824-btcdjmfp 66 2 survival survival NN cord-006824-btcdjmfp 66 3 is be VBZ cord-006824-btcdjmfp 66 4 50 50 CD cord-006824-btcdjmfp 66 5 % % NN cord-006824-btcdjmfp 66 6 with with IN cord-006824-btcdjmfp 66 7 relapse relapse NN cord-006824-btcdjmfp 66 8 causing cause VBG cord-006824-btcdjmfp 66 9 treatment treatment NN cord-006824-btcdjmfp 66 10 failure failure NN cord-006824-btcdjmfp 66 11 in in IN cord-006824-btcdjmfp 66 12 30 30 CD cord-006824-btcdjmfp 66 13 % % NN cord-006824-btcdjmfp 66 14 of of IN cord-006824-btcdjmfp 66 15 allogeneic allogeneic NN cord-006824-btcdjmfp 66 16 HCT hct NN cord-006824-btcdjmfp 66 17 recipients recipient NNS cord-006824-btcdjmfp 66 18 . . . cord-006824-btcdjmfp 67 1 The the DT cord-006824-btcdjmfp 67 2 remaining remain VBG cord-006824-btcdjmfp 67 3 20 20 CD cord-006824-btcdjmfp 67 4 % % NN cord-006824-btcdjmfp 67 5 of of IN cord-006824-btcdjmfp 67 6 patients patient NNS cord-006824-btcdjmfp 67 7 succumbed succumb VBN cord-006824-btcdjmfp 67 8 to to IN cord-006824-btcdjmfp 67 9 complications complication NNS cord-006824-btcdjmfp 67 10 such such JJ cord-006824-btcdjmfp 67 11 as as IN cord-006824-btcdjmfp 67 12 graft graft NN cord-006824-btcdjmfp 67 13 - - HYPH cord-006824-btcdjmfp 67 14 versus versus IN cord-006824-btcdjmfp 67 15 - - HYPH cord-006824-btcdjmfp 67 16 host host NN cord-006824-btcdjmfp 67 17 disease disease NN cord-006824-btcdjmfp 67 18 , , , cord-006824-btcdjmfp 67 19 infections infection NNS cord-006824-btcdjmfp 67 20 or or CC cord-006824-btcdjmfp 67 21 veno veno NN cord-006824-btcdjmfp 67 22 - - HYPH cord-006824-btcdjmfp 67 23 occlusive occlusive JJ cord-006824-btcdjmfp 67 24 disease disease NN cord-006824-btcdjmfp 67 25 . . . cord-006824-btcdjmfp 68 1 This this DT cord-006824-btcdjmfp 68 2 limited limited JJ cord-006824-btcdjmfp 68 3 experience experience NN cord-006824-btcdjmfp 68 4 is be VBZ cord-006824-btcdjmfp 68 5 nevertheless nevertheless RB cord-006824-btcdjmfp 68 6 representative representative JJ cord-006824-btcdjmfp 68 7 for for IN cord-006824-btcdjmfp 68 8 the the DT cord-006824-btcdjmfp 68 9 observations observation NNS cord-006824-btcdjmfp 68 10 made make VBN cord-006824-btcdjmfp 68 11 in in IN cord-006824-btcdjmfp 68 12 other other JJ cord-006824-btcdjmfp 68 13 trials trial NNS cord-006824-btcdjmfp 68 14 including include VBG cord-006824-btcdjmfp 68 15 results result NNS cord-006824-btcdjmfp 68 16 reported report VBN cord-006824-btcdjmfp 68 17 from from IN cord-006824-btcdjmfp 68 18 the the DT cord-006824-btcdjmfp 68 19 International International NNP cord-006824-btcdjmfp 68 20 Bone Bone NNP cord-006824-btcdjmfp 68 21 Marrow Marrow NNP cord-006824-btcdjmfp 68 22 Transplant Transplant NNP cord-006824-btcdjmfp 68 23 Registry Registry NNP cord-006824-btcdjmfp 68 24 . . . cord-006824-btcdjmfp 69 1 Without without IN cord-006824-btcdjmfp 69 2 question question NN cord-006824-btcdjmfp 69 3 , , , cord-006824-btcdjmfp 69 4 non non JJ cord-006824-btcdjmfp 69 5 - - JJ cord-006824-btcdjmfp 69 6 relapse relapse JJ cord-006824-btcdjmfp 69 7 mortality mortality NN cord-006824-btcdjmfp 69 8 ( ( -LRB- cord-006824-btcdjmfp 69 9 mostly mostly RB cord-006824-btcdjmfp 69 10 due due JJ cord-006824-btcdjmfp 69 11 to to IN cord-006824-btcdjmfp 69 12 GVHD GVHD NNP cord-006824-btcdjmfp 69 13 ) ) -RRB- cord-006824-btcdjmfp 69 14 is be VBZ cord-006824-btcdjmfp 69 15 a a DT cord-006824-btcdjmfp 69 16 major major JJ cord-006824-btcdjmfp 69 17 obstacle obstacle NN cord-006824-btcdjmfp 69 18 to to IN cord-006824-btcdjmfp 69 19 success success NN cord-006824-btcdjmfp 69 20 and and CC cord-006824-btcdjmfp 69 21 alternative alternative JJ cord-006824-btcdjmfp 69 22 technologies technology NNS cord-006824-btcdjmfp 69 23 need need VBP cord-006824-btcdjmfp 69 24 to to TO cord-006824-btcdjmfp 69 25 be be VB cord-006824-btcdjmfp 69 26 explored explore VBN cord-006824-btcdjmfp 69 27 . . . cord-006824-btcdjmfp 70 1 Very very RB cord-006824-btcdjmfp 70 2 promising promising JJ cord-006824-btcdjmfp 70 3 data datum NNS cord-006824-btcdjmfp 70 4 have have VBP cord-006824-btcdjmfp 70 5 recently recently RB cord-006824-btcdjmfp 70 6 been be VBN cord-006824-btcdjmfp 70 7 reported report VBN cord-006824-btcdjmfp 70 8 related relate VBN cord-006824-btcdjmfp 70 9 to to IN cord-006824-btcdjmfp 70 10 the the DT cord-006824-btcdjmfp 70 11 use use NN cord-006824-btcdjmfp 70 12 of of IN cord-006824-btcdjmfp 70 13 intensity intensity NN cord-006824-btcdjmfp 70 14 - - HYPH cord-006824-btcdjmfp 70 15 reduced reduce VBN cord-006824-btcdjmfp 70 16 regimens regimen NNS cord-006824-btcdjmfp 70 17 followed follow VBN cord-006824-btcdjmfp 70 18 by by IN cord-006824-btcdjmfp 70 19 allogeneic allogeneic NN cord-006824-btcdjmfp 70 20 HCT HCT NNP cord-006824-btcdjmfp 70 21 [ [ -LRB- cord-006824-btcdjmfp 70 22 10 10 CD cord-006824-btcdjmfp 70 23 ] ] -RRB- cord-006824-btcdjmfp 70 24 . . . cord-006824-btcdjmfp 71 1 It -PRON- PRP cord-006824-btcdjmfp 71 2 can can MD cord-006824-btcdjmfp 71 3 be be VB cord-006824-btcdjmfp 71 4 expected expect VBN cord-006824-btcdjmfp 71 5 that that IN cord-006824-btcdjmfp 71 6 this this DT cord-006824-btcdjmfp 71 7 novel novel JJ cord-006824-btcdjmfp 71 8 concept concept NN cord-006824-btcdjmfp 71 9 which which WDT cord-006824-btcdjmfp 71 10 relies rely VBZ cord-006824-btcdjmfp 71 11 mainly mainly RB cord-006824-btcdjmfp 71 12 on on IN cord-006824-btcdjmfp 71 13 a a DT cord-006824-btcdjmfp 71 14 graft graft NN cord-006824-btcdjmfp 71 15 - - HYPH cord-006824-btcdjmfp 71 16 versus versus IN cord-006824-btcdjmfp 71 17 - - HYPH cord-006824-btcdjmfp 71 18 lymphoma lymphoma NN cord-006824-btcdjmfp 71 19 effect effect NN cord-006824-btcdjmfp 71 20 will will MD cord-006824-btcdjmfp 71 21 lead lead VB cord-006824-btcdjmfp 71 22 to to IN cord-006824-btcdjmfp 71 23 an an DT cord-006824-btcdjmfp 71 24 increase increase NN cord-006824-btcdjmfp 71 25 in in IN cord-006824-btcdjmfp 71 26 the the DT cord-006824-btcdjmfp 71 27 successful successful JJ cord-006824-btcdjmfp 71 28 use use NN cord-006824-btcdjmfp 71 29 of of IN cord-006824-btcdjmfp 71 30 allogeneic allogeneic NN cord-006824-btcdjmfp 71 31 HCT hct NN cord-006824-btcdjmfp 71 32 while while IN cord-006824-btcdjmfp 71 33 the the DT cord-006824-btcdjmfp 71 34 procedure procedure NN cord-006824-btcdjmfp 71 35 - - HYPH cord-006824-btcdjmfp 71 36 related relate VBN cord-006824-btcdjmfp 71 37 mortality mortality NN cord-006824-btcdjmfp 71 38 is be VBZ cord-006824-btcdjmfp 71 39 dramatically dramatically RB cord-006824-btcdjmfp 71 40 decreased decrease VBN cord-006824-btcdjmfp 71 41 as as IN cord-006824-btcdjmfp 71 42 compared compare VBN cord-006824-btcdjmfp 71 43 to to IN cord-006824-btcdjmfp 71 44 high high JJ cord-006824-btcdjmfp 71 45 dose dose NN cord-006824-btcdjmfp 71 46 therapy therapy NN cord-006824-btcdjmfp 71 47 regimens regimen NNS cord-006824-btcdjmfp 71 48 . . . cord-006824-btcdjmfp 72 1 The the DT cord-006824-btcdjmfp 72 2 transplant transplant NN cord-006824-btcdjmfp 72 3 physician physician NN cord-006824-btcdjmfp 72 4 who who WP cord-006824-btcdjmfp 72 5 evaluates evaluate VBZ cord-006824-btcdjmfp 72 6 and and CC cord-006824-btcdjmfp 72 7 counsels counsel VBZ cord-006824-btcdjmfp 72 8 a a DT cord-006824-btcdjmfp 72 9 patient patient NN cord-006824-btcdjmfp 72 10 with with IN cord-006824-btcdjmfp 72 11 NHL NHL NNP cord-006824-btcdjmfp 72 12 concerning concern VBG cord-006824-btcdjmfp 72 13 the the DT cord-006824-btcdjmfp 72 14 type type NN cord-006824-btcdjmfp 72 15 of of IN cord-006824-btcdjmfp 72 16 transplantation transplantation NN cord-006824-btcdjmfp 72 17 is be VBZ cord-006824-btcdjmfp 72 18 faced face VBN cord-006824-btcdjmfp 72 19 with with IN cord-006824-btcdjmfp 72 20 a a DT cord-006824-btcdjmfp 72 21 serious serious JJ cord-006824-btcdjmfp 72 22 dilemma dilemma NN cord-006824-btcdjmfp 72 23 . . . cord-006824-btcdjmfp 73 1 Because because IN cord-006824-btcdjmfp 73 2 of of IN cord-006824-btcdjmfp 73 3 the the DT cord-006824-btcdjmfp 73 4 heterogeneity heterogeneity NN cord-006824-btcdjmfp 73 5 of of IN cord-006824-btcdjmfp 73 6 the the DT cord-006824-btcdjmfp 73 7 underlying underlie VBG cord-006824-btcdjmfp 73 8 disease disease NN cord-006824-btcdjmfp 73 9 , , , cord-006824-btcdjmfp 73 10 it -PRON- PRP cord-006824-btcdjmfp 73 11 has have VBZ cord-006824-btcdjmfp 73 12 so so RB cord-006824-btcdjmfp 73 13 far far RB cord-006824-btcdjmfp 73 14 not not RB cord-006824-btcdjmfp 73 15 been be VBN cord-006824-btcdjmfp 73 16 possible possible JJ cord-006824-btcdjmfp 73 17 to to TO cord-006824-btcdjmfp 73 18 come come VB cord-006824-btcdjmfp 73 19 to to IN cord-006824-btcdjmfp 73 20 a a DT cord-006824-btcdjmfp 73 21 clear clear JJ cord-006824-btcdjmfp 73 22 recommendation recommendation NN cord-006824-btcdjmfp 73 23 which which WDT cord-006824-btcdjmfp 73 24 of of IN cord-006824-btcdjmfp 73 25 the the DT cord-006824-btcdjmfp 73 26 types type NNS cord-006824-btcdjmfp 73 27 of of IN cord-006824-btcdjmfp 73 28 HCT HCT NNP cord-006824-btcdjmfp 73 29 should should MD cord-006824-btcdjmfp 73 30 be be VB cord-006824-btcdjmfp 73 31 pursued pursue VBN cord-006824-btcdjmfp 73 32 for for IN cord-006824-btcdjmfp 73 33 any any DT cord-006824-btcdjmfp 73 34 given give VBN cord-006824-btcdjmfp 73 35 patient patient NN cord-006824-btcdjmfp 73 36 , , , cord-006824-btcdjmfp 73 37 autologous autologous JJ cord-006824-btcdjmfp 73 38 or or CC cord-006824-btcdjmfp 73 39 allogeneic allogeneic IN cord-006824-btcdjmfp 73 40 HCT hct NN cord-006824-btcdjmfp 73 41 . . . cord-006824-btcdjmfp 74 1 The the DT cord-006824-btcdjmfp 74 2 earliest early JJS cord-006824-btcdjmfp 74 3 comparison comparison NN cord-006824-btcdjmfp 74 4 was be VBD cord-006824-btcdjmfp 74 5 reported report VBN cord-006824-btcdjmfp 74 6 15 15 CD cord-006824-btcdjmfp 74 7 years year NNS cord-006824-btcdjmfp 74 8 ago ago RB cord-006824-btcdjmfp 74 9 and and CC cord-006824-btcdjmfp 74 10 indicated indicate VBD cord-006824-btcdjmfp 74 11 equivalence equivalence NN cord-006824-btcdjmfp 74 12 in in IN cord-006824-btcdjmfp 74 13 outcome outcome NN cord-006824-btcdjmfp 74 14 [ [ -LRB- cord-006824-btcdjmfp 74 15 11 11 CD cord-006824-btcdjmfp 74 16 ] ] -RRB- cord-006824-btcdjmfp 74 17 . . . cord-006824-btcdjmfp 75 1 Since since IN cord-006824-btcdjmfp 75 2 then then RB cord-006824-btcdjmfp 75 3 , , , cord-006824-btcdjmfp 75 4 another another DT cord-006824-btcdjmfp 75 5 10 10 CD cord-006824-btcdjmfp 75 6 comparative comparative JJ cord-006824-btcdjmfp 75 7 studies study NNS cord-006824-btcdjmfp 75 8 have have VBP cord-006824-btcdjmfp 75 9 been be VBN cord-006824-btcdjmfp 75 10 described describe VBN cord-006824-btcdjmfp 75 11 in in IN cord-006824-btcdjmfp 75 12 the the DT cord-006824-btcdjmfp 75 13 peer peer NN cord-006824-btcdjmfp 75 14 reviewed review VBD cord-006824-btcdjmfp 75 15 literature literature NN cord-006824-btcdjmfp 75 16 . . . cord-006824-btcdjmfp 76 1 In in IN cord-006824-btcdjmfp 76 2 these these DT cord-006824-btcdjmfp 76 3 trials trial NNS cord-006824-btcdjmfp 76 4 , , , cord-006824-btcdjmfp 76 5 1,183 1,183 CD cord-006824-btcdjmfp 76 6 al al NNP cord-006824-btcdjmfp 76 7 - - HYPH cord-006824-btcdjmfp 76 8 lograft lograft NNP cord-006824-btcdjmfp 76 9 recipients recipient NNS cord-006824-btcdjmfp 76 10 were be VBD cord-006824-btcdjmfp 76 11 compared compare VBN cord-006824-btcdjmfp 76 12 to to IN cord-006824-btcdjmfp 76 13 10,087 10,087 CD cord-006824-btcdjmfp 76 14 autograft autograft NN cord-006824-btcdjmfp 76 15 recipients recipient NNS cord-006824-btcdjmfp 76 16 [ [ -LRB- cord-006824-btcdjmfp 76 17 12 12 CD cord-006824-btcdjmfp 76 18 ] ] -RRB- cord-006824-btcdjmfp 76 19 . . . cord-006824-btcdjmfp 77 1 Differences difference NNS cord-006824-btcdjmfp 77 2 in in IN cord-006824-btcdjmfp 77 3 histology histology NN cord-006824-btcdjmfp 77 4 , , , cord-006824-btcdjmfp 77 5 remission remission NN cord-006824-btcdjmfp 77 6 status status NN cord-006824-btcdjmfp 77 7 , , , cord-006824-btcdjmfp 77 8 source source NN cord-006824-btcdjmfp 77 9 of of IN cord-006824-btcdjmfp 77 10 autologous autologous JJ cord-006824-btcdjmfp 77 11 or or CC cord-006824-btcdjmfp 77 12 allogeneic allogeneic IN cord-006824-btcdjmfp 77 13 cells cell NNS cord-006824-btcdjmfp 77 14 ( ( -LRB- cord-006824-btcdjmfp 77 15 marrow marrow NN cord-006824-btcdjmfp 77 16 versus versus IN cord-006824-btcdjmfp 77 17 peripheral peripheral JJ cord-006824-btcdjmfp 77 18 blood blood NN cord-006824-btcdjmfp 77 19 , , , cord-006824-btcdjmfp 77 20 related relate VBN cord-006824-btcdjmfp 77 21 versus versus IN cord-006824-btcdjmfp 77 22 unrelated unrelated JJ cord-006824-btcdjmfp 77 23 donor donor NN cord-006824-btcdjmfp 77 24 ) ) -RRB- cord-006824-btcdjmfp 77 25 and and CC cord-006824-btcdjmfp 77 26 post post JJ cord-006824-btcdjmfp 77 27 - - JJ cord-006824-btcdjmfp 77 28 transplant transplant JJ cord-006824-btcdjmfp 77 29 management management NN cord-006824-btcdjmfp 77 30 make make VBP cord-006824-btcdjmfp 77 31 even even RB cord-006824-btcdjmfp 77 32 a a DT cord-006824-btcdjmfp 77 33 meta meta JJ cord-006824-btcdjmfp 77 34 - - HYPH cord-006824-btcdjmfp 77 35 analysis analysis NN cord-006824-btcdjmfp 77 36 relatively relatively RB cord-006824-btcdjmfp 77 37 meaningless meaningless JJ cord-006824-btcdjmfp 77 38 . . . cord-006824-btcdjmfp 78 1 One one PRP cord-006824-btcdjmfp 78 2 can can MD cord-006824-btcdjmfp 78 3 only only RB cord-006824-btcdjmfp 78 4 conclude conclude VB cord-006824-btcdjmfp 78 5 that that IN cord-006824-btcdjmfp 78 6 autologous autologous JJ cord-006824-btcdjmfp 78 7 HCT hct NN cord-006824-btcdjmfp 78 8 is be VBZ cord-006824-btcdjmfp 78 9 associated associate VBN cord-006824-btcdjmfp 78 10 with with IN cord-006824-btcdjmfp 78 11 a a DT cord-006824-btcdjmfp 78 12 post post JJ cord-006824-btcdjmfp 78 13 - - JJ cord-006824-btcdjmfp 78 14 transplant transplant JJ cord-006824-btcdjmfp 78 15 relapse relapse NN cord-006824-btcdjmfp 78 16 rate rate NN cord-006824-btcdjmfp 78 17 in in IN cord-006824-btcdjmfp 78 18 the the DT cord-006824-btcdjmfp 78 19 order order NN cord-006824-btcdjmfp 78 20 of of IN cord-006824-btcdjmfp 78 21 40 40 CD cord-006824-btcdjmfp 78 22 - - SYM cord-006824-btcdjmfp 78 23 50 50 CD cord-006824-btcdjmfp 78 24 % % NN cord-006824-btcdjmfp 78 25 while while IN cord-006824-btcdjmfp 78 26 allogeneic allogeneic NN cord-006824-btcdjmfp 78 27 HCT HCT NNP cord-006824-btcdjmfp 78 28 is be VBZ cord-006824-btcdjmfp 78 29 complicated complicate VBN cord-006824-btcdjmfp 78 30 mostly mostly RB cord-006824-btcdjmfp 78 31 by by IN cord-006824-btcdjmfp 78 32 GVHD GVHD NNP cord-006824-btcdjmfp 78 33 and and CC cord-006824-btcdjmfp 78 34 related related JJ cord-006824-btcdjmfp 78 35 toxicities toxicity NNS cord-006824-btcdjmfp 78 36 resulting result VBG cord-006824-btcdjmfp 78 37 in in IN cord-006824-btcdjmfp 78 38 equivalent equivalent JJ cord-006824-btcdjmfp 78 39 outcomes outcome NNS cord-006824-btcdjmfp 78 40 for for IN cord-006824-btcdjmfp 78 41 patients patient NNS cord-006824-btcdjmfp 78 42 with with IN cord-006824-btcdjmfp 78 43 NHL NHL NNP cord-006824-btcdjmfp 78 44 . . . cord-006824-btcdjmfp 79 1 A a DT cord-006824-btcdjmfp 79 2 collaborative collaborative JJ cord-006824-btcdjmfp 79 3 trial trial NN cord-006824-btcdjmfp 79 4 is be VBZ cord-006824-btcdjmfp 79 5 currently currently RB cord-006824-btcdjmfp 79 6 planned plan VBN cord-006824-btcdjmfp 79 7 by by IN cord-006824-btcdjmfp 79 8 the the DT cord-006824-btcdjmfp 79 9 Bone Bone NNP cord-006824-btcdjmfp 79 10 Marrow Marrow NNP cord-006824-btcdjmfp 79 11 Transplant Transplant NNP cord-006824-btcdjmfp 79 12 Clinical Clinical NNP cord-006824-btcdjmfp 79 13 Trials Trials NNPS cord-006824-btcdjmfp 79 14 Network Network NNP cord-006824-btcdjmfp 79 15 in in IN cord-006824-btcdjmfp 79 16 the the DT cord-006824-btcdjmfp 79 17 United United NNP cord-006824-btcdjmfp 79 18 States States NNP cord-006824-btcdjmfp 79 19 to to TO cord-006824-btcdjmfp 79 20 address address VB cord-006824-btcdjmfp 79 21 this this DT cord-006824-btcdjmfp 79 22 important important JJ cord-006824-btcdjmfp 79 23 question question NN cord-006824-btcdjmfp 79 24 which which WDT cord-006824-btcdjmfp 79 25 should should MD cord-006824-btcdjmfp 79 26 help help VB cord-006824-btcdjmfp 79 27 to to TO cord-006824-btcdjmfp 79 28 facilitate facilitate VB cord-006824-btcdjmfp 79 29 the the DT cord-006824-btcdjmfp 79 30 proper proper JJ cord-006824-btcdjmfp 79 31 choice choice NN cord-006824-btcdjmfp 79 32 for for IN cord-006824-btcdjmfp 79 33 transplant transplant NN cord-006824-btcdjmfp 79 34 candidates candidate NNS cord-006824-btcdjmfp 79 35 . . . cord-006824-btcdjmfp 80 1 For for IN cord-006824-btcdjmfp 80 2 the the DT cord-006824-btcdjmfp 80 3 time time NN cord-006824-btcdjmfp 80 4 being be VBG cord-006824-btcdjmfp 80 5 , , , cord-006824-btcdjmfp 80 6 most most JJS cord-006824-btcdjmfp 80 7 centers center NNS cord-006824-btcdjmfp 80 8 would would MD cord-006824-btcdjmfp 80 9 utilize utilize VB cord-006824-btcdjmfp 80 10 HCT hct NN cord-006824-btcdjmfp 80 11 if if IN cord-006824-btcdjmfp 80 12 a a DT cord-006824-btcdjmfp 80 13 suitably suitably RB cord-006824-btcdjmfp 80 14 matched match VBN cord-006824-btcdjmfp 80 15 donor donor NN cord-006824-btcdjmfp 80 16 is be VBZ cord-006824-btcdjmfp 80 17 available available JJ cord-006824-btcdjmfp 80 18 and and CC cord-006824-btcdjmfp 80 19 to to TO cord-006824-btcdjmfp 80 20 offer offer VB cord-006824-btcdjmfp 80 21 autologous autologous JJ cord-006824-btcdjmfp 80 22 HCT hct NN cord-006824-btcdjmfp 80 23 in in IN cord-006824-btcdjmfp 80 24 the the DT cord-006824-btcdjmfp 80 25 absence absence NN cord-006824-btcdjmfp 80 26 of of IN cord-006824-btcdjmfp 80 27 a a DT cord-006824-btcdjmfp 80 28 compatible compatible JJ cord-006824-btcdjmfp 80 29 donor donor NN cord-006824-btcdjmfp 80 30 . . . cord-006824-btcdjmfp 80 31 _SP cord-006824-btcdjmfp 81 1 Mortality mortality NN cord-006824-btcdjmfp 81 2 after after IN cord-006824-btcdjmfp 81 3 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 81 4 stem stem NN cord-006824-btcdjmfp 81 5 cell cell NN cord-006824-btcdjmfp 81 6 transplantation transplantation NN cord-006824-btcdjmfp 81 7 ( ( -LRB- cord-006824-btcdjmfp 81 8 HSCT HSCT NNP cord-006824-btcdjmfp 81 9 ) ) -RRB- cord-006824-btcdjmfp 81 10 could could MD cord-006824-btcdjmfp 81 11 be be VB cord-006824-btcdjmfp 81 12 reduced reduce VBN cord-006824-btcdjmfp 81 13 to to IN cord-006824-btcdjmfp 81 14 approximately approximately RB cord-006824-btcdjmfp 81 15 10 10 CD cord-006824-btcdjmfp 81 16 % % NN cord-006824-btcdjmfp 81 17 in in IN cord-006824-btcdjmfp 81 18 HLA HLA NNP cord-006824-btcdjmfp 81 19 - - HYPH cord-006824-btcdjmfp 81 20 identical identical JJ cord-006824-btcdjmfp 81 21 intrafamiliary intrafamiliary JJ cord-006824-btcdjmfp 81 22 pediatric pediatric JJ cord-006824-btcdjmfp 81 23 transplantations transplantation NNS cord-006824-btcdjmfp 81 24 and and CC cord-006824-btcdjmfp 81 25 ranges range VBZ cord-006824-btcdjmfp 81 26 between between IN cord-006824-btcdjmfp 81 27 20 20 CD cord-006824-btcdjmfp 81 28 and and CC cord-006824-btcdjmfp 81 29 40 40 CD cord-006824-btcdjmfp 81 30 % % NN cord-006824-btcdjmfp 81 31 in in IN cord-006824-btcdjmfp 81 32 HLA HLA NNP cord-006824-btcdjmfp 81 33 - - HYPH cord-006824-btcdjmfp 81 34 different different JJ cord-006824-btcdjmfp 81 35 , , , cord-006824-btcdjmfp 81 36 intrafamiliary intrafamiliary JJ cord-006824-btcdjmfp 81 37 as as RB cord-006824-btcdjmfp 81 38 well well RB cord-006824-btcdjmfp 81 39 as as IN cord-006824-btcdjmfp 81 40 HLA HLA NNP cord-006824-btcdjmfp 81 41 - - HYPH cord-006824-btcdjmfp 81 42 unrelated unrelated JJ cord-006824-btcdjmfp 81 43 transplantations transplantation NNS cord-006824-btcdjmfp 81 44 . . . cord-006824-btcdjmfp 82 1 In in IN cord-006824-btcdjmfp 82 2 contrast contrast NN cord-006824-btcdjmfp 82 3 , , , cord-006824-btcdjmfp 82 4 pulmonary pulmonary JJ cord-006824-btcdjmfp 82 5 complications complication NNS cord-006824-btcdjmfp 82 6 are be VBP cord-006824-btcdjmfp 82 7 a a DT cord-006824-btcdjmfp 82 8 leading leading JJ cord-006824-btcdjmfp 82 9 cause cause NN cord-006824-btcdjmfp 82 10 of of IN cord-006824-btcdjmfp 82 11 mortality mortality NN cord-006824-btcdjmfp 82 12 after after IN cord-006824-btcdjmfp 82 13 HSCT HSCT NNP cord-006824-btcdjmfp 82 14 and and CC cord-006824-btcdjmfp 82 15 contribute contribute VBP cord-006824-btcdjmfp 82 16 markedly markedly RB cord-006824-btcdjmfp 82 17 to to IN cord-006824-btcdjmfp 82 18 the the DT cord-006824-btcdjmfp 82 19 morbidity morbidity NN cord-006824-btcdjmfp 82 20 [ [ -LRB- cord-006824-btcdjmfp 82 21 33 33 CD cord-006824-btcdjmfp 82 22 ] ] -RRB- cord-006824-btcdjmfp 82 23 . . . cord-006824-btcdjmfp 83 1 The the DT cord-006824-btcdjmfp 83 2 pathophysiology pathophysiology NN cord-006824-btcdjmfp 83 3 of of IN cord-006824-btcdjmfp 83 4 these these DT cord-006824-btcdjmfp 83 5 diseases disease NNS cord-006824-btcdjmfp 83 6 is be VBZ cord-006824-btcdjmfp 83 7 poorly poorly RB cord-006824-btcdjmfp 83 8 understood understand VBN cord-006824-btcdjmfp 83 9 and and CC cord-006824-btcdjmfp 83 10 their -PRON- PRP$ cord-006824-btcdjmfp 83 11 classification classification NN cord-006824-btcdjmfp 83 12 is be VBZ cord-006824-btcdjmfp 83 13 highly highly RB cord-006824-btcdjmfp 83 14 descriptive descriptive JJ cord-006824-btcdjmfp 83 15 . . . cord-006824-btcdjmfp 84 1 This this DT cord-006824-btcdjmfp 84 2 overview overview NN cord-006824-btcdjmfp 84 3 is be VBZ cord-006824-btcdjmfp 84 4 focussed focusse VBN cord-006824-btcdjmfp 84 5 on on IN cord-006824-btcdjmfp 84 6 the the DT cord-006824-btcdjmfp 84 7 pediatric pediatric JJ cord-006824-btcdjmfp 84 8 age age NN cord-006824-btcdjmfp 84 9 group group NN cord-006824-btcdjmfp 84 10 and and CC cord-006824-btcdjmfp 84 11 ( ( -LRB- cord-006824-btcdjmfp 84 12 1 1 CD cord-006824-btcdjmfp 84 13 ) ) -RRB- cord-006824-btcdjmfp 84 14 elucidates elucidate VBZ cord-006824-btcdjmfp 84 15 the the DT cord-006824-btcdjmfp 84 16 circumstances circumstance NNS cord-006824-btcdjmfp 84 17 which which WDT cord-006824-btcdjmfp 84 18 render render VBP cord-006824-btcdjmfp 84 19 recipients recipient NNS cord-006824-btcdjmfp 84 20 at at IN cord-006824-btcdjmfp 84 21 increased increase VBN cord-006824-btcdjmfp 84 22 risk risk NN cord-006824-btcdjmfp 84 23 of of IN cord-006824-btcdjmfp 84 24 non non JJ cord-006824-btcdjmfp 84 25 - - JJ cord-006824-btcdjmfp 84 26 infectious infectious JJ cord-006824-btcdjmfp 84 27 pulmonary pulmonary JJ cord-006824-btcdjmfp 84 28 complications complication NNS cord-006824-btcdjmfp 84 29 , , , cord-006824-btcdjmfp 84 30 ( ( -LRB- cord-006824-btcdjmfp 84 31 2 2 LS cord-006824-btcdjmfp 84 32 ) ) -RRB- cord-006824-btcdjmfp 84 33 describes describe VBZ cord-006824-btcdjmfp 84 34 the the DT cord-006824-btcdjmfp 84 35 diseases disease NNS cord-006824-btcdjmfp 84 36 and and CC cord-006824-btcdjmfp 84 37 alterations alteration NNS cord-006824-btcdjmfp 84 38 which which WDT cord-006824-btcdjmfp 84 39 are be VBP cord-006824-btcdjmfp 84 40 encountered encounter VBN cord-006824-btcdjmfp 84 41 , , , cord-006824-btcdjmfp 84 42 and and CC cord-006824-btcdjmfp 84 43 ( ( -LRB- cord-006824-btcdjmfp 84 44 3 3 LS cord-006824-btcdjmfp 84 45 ) ) -RRB- cord-006824-btcdjmfp 84 46 discusses discuss VBZ cord-006824-btcdjmfp 84 47 diagnostic diagnostic JJ cord-006824-btcdjmfp 84 48 and and CC cord-006824-btcdjmfp 84 49 therapeutic therapeutic JJ cord-006824-btcdjmfp 84 50 consequences consequence NNS cord-006824-btcdjmfp 84 51 . . . cord-006824-btcdjmfp 85 1 The the DT cord-006824-btcdjmfp 85 2 number number NN cord-006824-btcdjmfp 85 3 of of IN cord-006824-btcdjmfp 85 4 hematopoetic hematopoetic JJ cord-006824-btcdjmfp 85 5 stem stem NN cord-006824-btcdjmfp 85 6 cell cell NN cord-006824-btcdjmfp 85 7 transplantations transplantation NNS cord-006824-btcdjmfp 85 8 has have VBZ cord-006824-btcdjmfp 85 9 increased increase VBN cord-006824-btcdjmfp 85 10 in in IN cord-006824-btcdjmfp 85 11 recent recent JJ cord-006824-btcdjmfp 85 12 years year NNS cord-006824-btcdjmfp 85 13 [ [ -LRB- cord-006824-btcdjmfp 85 14 53 53 CD cord-006824-btcdjmfp 85 15 ] ] -RRB- cord-006824-btcdjmfp 85 16 . . . cord-006824-btcdjmfp 86 1 Statistically statistically RB cord-006824-btcdjmfp 86 2 , , , cord-006824-btcdjmfp 86 3 pulmonary pulmonary JJ cord-006824-btcdjmfp 86 4 complications complication NNS cord-006824-btcdjmfp 86 5 with with IN cord-006824-btcdjmfp 86 6 respiratory respiratory JJ cord-006824-btcdjmfp 86 7 insufficiency insufficiency NN cord-006824-btcdjmfp 86 8 account account NN cord-006824-btcdjmfp 86 9 for for IN cord-006824-btcdjmfp 86 10 as as RB cord-006824-btcdjmfp 86 11 much much JJ cord-006824-btcdjmfp 86 12 as as IN cord-006824-btcdjmfp 86 13 60 60 CD cord-006824-btcdjmfp 86 14 % % NN cord-006824-btcdjmfp 86 15 of of IN cord-006824-btcdjmfp 86 16 the the DT cord-006824-btcdjmfp 86 17 mortality mortality NN cord-006824-btcdjmfp 86 18 , , , cord-006824-btcdjmfp 86 19 depending depend VBG cord-006824-btcdjmfp 86 20 on on IN cord-006824-btcdjmfp 86 21 the the DT cord-006824-btcdjmfp 86 22 patients patient NNS cord-006824-btcdjmfp 86 23 ' ' POS cord-006824-btcdjmfp 86 24 age age NN cord-006824-btcdjmfp 86 25 [ [ -LRB- cord-006824-btcdjmfp 86 26 12 12 CD cord-006824-btcdjmfp 86 27 , , , cord-006824-btcdjmfp 86 28 19 19 CD cord-006824-btcdjmfp 86 29 , , , cord-006824-btcdjmfp 86 30 36 36 CD cord-006824-btcdjmfp 86 31 , , , cord-006824-btcdjmfp 86 32 70 70 CD cord-006824-btcdjmfp 86 33 , , , cord-006824-btcdjmfp 86 34 64 64 CD cord-006824-btcdjmfp 86 35 ] ] -RRB- cord-006824-btcdjmfp 86 36 . . . cord-006824-btcdjmfp 87 1 Furthermore furthermore RB cord-006824-btcdjmfp 87 2 , , , cord-006824-btcdjmfp 87 3 respiratory respiratory JJ cord-006824-btcdjmfp 87 4 insufficiency insufficiency NN cord-006824-btcdjmfp 87 5 is be VBZ cord-006824-btcdjmfp 87 6 included include VBN cord-006824-btcdjmfp 87 7 under under IN cord-006824-btcdjmfp 87 8 diagnoses diagnosis NNS cord-006824-btcdjmfp 87 9 such such JJ cord-006824-btcdjmfp 87 10 as as IN cord-006824-btcdjmfp 87 11 graft graft NN cord-006824-btcdjmfp 87 12 - - HYPH cord-006824-btcdjmfp 87 13 versus versus IN cord-006824-btcdjmfp 87 14 - - HYPH cord-006824-btcdjmfp 87 15 host host NN cord-006824-btcdjmfp 87 16 - - HYPH cord-006824-btcdjmfp 87 17 disease disease NN cord-006824-btcdjmfp 87 18 ( ( -LRB- cord-006824-btcdjmfp 87 19 GVHD GVHD NNP cord-006824-btcdjmfp 87 20 ) ) -RRB- cord-006824-btcdjmfp 87 21 or or CC cord-006824-btcdjmfp 87 22 multi multi JJ cord-006824-btcdjmfp 87 23 organ organ NN cord-006824-btcdjmfp 87 24 insufficiency insufficiency NN cord-006824-btcdjmfp 87 25 . . . cord-006824-btcdjmfp 88 1 The the DT cord-006824-btcdjmfp 88 2 largest large JJS cord-006824-btcdjmfp 88 3 retrospective retrospective JJ cord-006824-btcdjmfp 88 4 analysis analysis NN cord-006824-btcdjmfp 88 5 of of IN cord-006824-btcdjmfp 88 6 Italian italian JJ cord-006824-btcdjmfp 88 7 children child NNS cord-006824-btcdjmfp 88 8 after after IN cord-006824-btcdjmfp 88 9 allogeneic allogeneic NN cord-006824-btcdjmfp 88 10 stem stem NN cord-006824-btcdjmfp 88 11 cell cell NN cord-006824-btcdjmfp 88 12 transplantation transplantation NN cord-006824-btcdjmfp 88 13 demonstrated demonstrate VBD cord-006824-btcdjmfp 88 14 a a DT cord-006824-btcdjmfp 88 15 pulmonary pulmonary JJ cord-006824-btcdjmfp 88 16 mortality mortality NN cord-006824-btcdjmfp 88 17 of of IN cord-006824-btcdjmfp 88 18 9 9 CD cord-006824-btcdjmfp 88 19 % % NN cord-006824-btcdjmfp 88 20 [ [ -LRB- cord-006824-btcdjmfp 88 21 28 28 CD cord-006824-btcdjmfp 88 22 ] ] -RRB- cord-006824-btcdjmfp 88 23 . . . cord-006824-btcdjmfp 89 1 Case case NN cord-006824-btcdjmfp 89 2 reports report NNS cord-006824-btcdjmfp 89 3 as as RB cord-006824-btcdjmfp 89 4 well well RB cord-006824-btcdjmfp 89 5 as as IN cord-006824-btcdjmfp 90 1 retrospective retrospective JJ cord-006824-btcdjmfp 90 2 or or CC cord-006824-btcdjmfp 90 3 prospective prospective JJ cord-006824-btcdjmfp 90 4 analyses analysis NNS cord-006824-btcdjmfp 90 5 of of IN cord-006824-btcdjmfp 90 6 different different JJ cord-006824-btcdjmfp 90 7 patient patient NN cord-006824-btcdjmfp 90 8 cohorts cohort NNS cord-006824-btcdjmfp 90 9 demonstrate demonstrate VBP cord-006824-btcdjmfp 90 10 between between IN cord-006824-btcdjmfp 90 11 10 10 CD cord-006824-btcdjmfp 90 12 % % NN cord-006824-btcdjmfp 90 13 and and CC cord-006824-btcdjmfp 90 14 40 40 CD cord-006824-btcdjmfp 90 15 % % NN cord-006824-btcdjmfp 90 16 incidence incidence NN cord-006824-btcdjmfp 90 17 of of IN cord-006824-btcdjmfp 90 18 irreversible irreversible JJ cord-006824-btcdjmfp 90 19 pulmonary pulmonary JJ cord-006824-btcdjmfp 90 20 function function NN cord-006824-btcdjmfp 90 21 loss loss NN cord-006824-btcdjmfp 90 22 after after IN cord-006824-btcdjmfp 90 23 HSCT HSCT NNP cord-006824-btcdjmfp 90 24 [ [ -LRB- cord-006824-btcdjmfp 90 25 68 68 CD cord-006824-btcdjmfp 90 26 , , , cord-006824-btcdjmfp 90 27 14 14 CD cord-006824-btcdjmfp 90 28 , , , cord-006824-btcdjmfp 90 29 48 48 CD cord-006824-btcdjmfp 90 30 , , , cord-006824-btcdjmfp 90 31 65 65 CD cord-006824-btcdjmfp 90 32 , , , cord-006824-btcdjmfp 90 33 43 43 CD cord-006824-btcdjmfp 90 34 , , , cord-006824-btcdjmfp 90 35 11 11 CD cord-006824-btcdjmfp 90 36 ] ] -RRB- cord-006824-btcdjmfp 90 37 . . . cord-006824-btcdjmfp 91 1 The the DT cord-006824-btcdjmfp 91 2 incidence incidence NN cord-006824-btcdjmfp 91 3 of of IN cord-006824-btcdjmfp 91 4 late late JJ cord-006824-btcdjmfp 91 5 - - HYPH cord-006824-btcdjmfp 91 6 onset onset NN cord-006824-btcdjmfp 91 7 non non JJ cord-006824-btcdjmfp 91 8 infectious infectious JJ cord-006824-btcdjmfp 91 9 pulmonary pulmonary JJ cord-006824-btcdjmfp 91 10 complications complication NNS cord-006824-btcdjmfp 91 11 ( ( -LRB- cord-006824-btcdjmfp 91 12 LONIPC LONIPC NNP cord-006824-btcdjmfp 91 13 ) ) -RRB- cord-006824-btcdjmfp 91 14 is be VBZ cord-006824-btcdjmfp 91 15 estimated estimate VBN cord-006824-btcdjmfp 91 16 to to TO cord-006824-btcdjmfp 91 17 be be VB cord-006824-btcdjmfp 91 18 approximately approximately RB cord-006824-btcdjmfp 91 19 10 10 CD cord-006824-btcdjmfp 91 20 % % NN cord-006824-btcdjmfp 91 21 . . . cord-006824-btcdjmfp 92 1 In in IN cord-006824-btcdjmfp 92 2 one one CD cord-006824-btcdjmfp 92 3 study study NN cord-006824-btcdjmfp 92 4 18 18 CD cord-006824-btcdjmfp 92 5 out out IN cord-006824-btcdjmfp 92 6 of of IN cord-006824-btcdjmfp 92 7 179 179 CD cord-006824-btcdjmfp 92 8 patients patient NNS cord-006824-btcdjmfp 92 9 suffered suffer VBD cord-006824-btcdjmfp 92 10 such such JJ cord-006824-btcdjmfp 92 11 complications complication NNS cord-006824-btcdjmfp 92 12 three three CD cord-006824-btcdjmfp 92 13 months month NNS cord-006824-btcdjmfp 92 14 after after IN cord-006824-btcdjmfp 92 15 allogeneic allogeneic NN cord-006824-btcdjmfp 92 16 HSCT HSCT NNP cord-006824-btcdjmfp 92 17 [ [ -LRB- cord-006824-btcdjmfp 92 18 60 60 CD cord-006824-btcdjmfp 92 19 , , , cord-006824-btcdjmfp 92 20 10 10 CD cord-006824-btcdjmfp 92 21 ] ] -RRB- cord-006824-btcdjmfp 92 22 . . . cord-006824-btcdjmfp 93 1 There there EX cord-006824-btcdjmfp 93 2 has have VBZ cord-006824-btcdjmfp 93 3 been be VBN cord-006824-btcdjmfp 93 4 no no DT cord-006824-btcdjmfp 93 5 improvement improvement NN cord-006824-btcdjmfp 93 6 over over IN cord-006824-btcdjmfp 93 7 the the DT cord-006824-btcdjmfp 93 8 past past JJ cord-006824-btcdjmfp 93 9 decade decade NN cord-006824-btcdjmfp 93 10 ( ( -LRB- cord-006824-btcdjmfp 93 11 11 11 CD cord-006824-btcdjmfp 93 12 ) ) -RRB- cord-006824-btcdjmfp 93 13 . . . cord-006824-btcdjmfp 94 1 Risk risk NN cord-006824-btcdjmfp 94 2 factors factor NNS cord-006824-btcdjmfp 94 3 are be VBP cord-006824-btcdjmfp 94 4 intrinsic intrinsic JJ cord-006824-btcdjmfp 94 5 to to IN cord-006824-btcdjmfp 94 6 the the DT cord-006824-btcdjmfp 94 7 procedure procedure NN cord-006824-btcdjmfp 94 8 ( ( -LRB- cord-006824-btcdjmfp 94 9 autologous autologous JJ cord-006824-btcdjmfp 94 10 vs. vs. FW cord-006824-btcdjmfp 94 11 allogeneic allogeneic NN cord-006824-btcdjmfp 94 12 transplantation transplantation NN cord-006824-btcdjmfp 94 13 with with IN cord-006824-btcdjmfp 94 14 rejection rejection NN cord-006824-btcdjmfp 94 15 by by IN cord-006824-btcdjmfp 94 16 residual residual JJ cord-006824-btcdjmfp 94 17 host host NN cord-006824-btcdjmfp 94 18 T t NN cord-006824-btcdjmfp 94 19 - - HYPH cord-006824-btcdjmfp 94 20 cells cell NNS cord-006824-btcdjmfp 94 21 , , , cord-006824-btcdjmfp 94 22 GVHD GVHD NNP cord-006824-btcdjmfp 94 23 ) ) -RRB- cord-006824-btcdjmfp 94 24 , , , cord-006824-btcdjmfp 94 25 to to IN cord-006824-btcdjmfp 94 26 the the DT cord-006824-btcdjmfp 94 27 immunosuppression immunosuppression NN cord-006824-btcdjmfp 94 28 ( ( -LRB- cord-006824-btcdjmfp 94 29 total total JJ cord-006824-btcdjmfp 94 30 body body NN cord-006824-btcdjmfp 94 31 irradiation irradiation NN cord-006824-btcdjmfp 94 32 , , , cord-006824-btcdjmfp 94 33 cyclophosphamide cyclophosphamide NN cord-006824-btcdjmfp 94 34 and and CC cord-006824-btcdjmfp 94 35 busulfan busulfan NN cord-006824-btcdjmfp 94 36 , , , cord-006824-btcdjmfp 94 37 both both DT cord-006824-btcdjmfp 94 38 leading lead VBG cord-006824-btcdjmfp 94 39 to to IN cord-006824-btcdjmfp 94 40 interstitial interstitial JJ cord-006824-btcdjmfp 94 41 pulmonary pulmonary JJ cord-006824-btcdjmfp 94 42 fibrosis fibrosis NN cord-006824-btcdjmfp 94 43 ) ) -RRB- cord-006824-btcdjmfp 94 44 , , , cord-006824-btcdjmfp 94 45 to to IN cord-006824-btcdjmfp 94 46 the the DT cord-006824-btcdjmfp 94 47 underlying underlie VBG cord-006824-btcdjmfp 94 48 disease disease NN cord-006824-btcdjmfp 94 49 ( ( -LRB- cord-006824-btcdjmfp 94 50 sickle sickle NN cord-006824-btcdjmfp 94 51 - - HYPH cord-006824-btcdjmfp 94 52 cell cell NN cord-006824-btcdjmfp 94 53 anemia anemia NN cord-006824-btcdjmfp 94 54 with with IN cord-006824-btcdjmfp 94 55 recurrent recurrent JJ cord-006824-btcdjmfp 94 56 episodes episode NNS cord-006824-btcdjmfp 94 57 of of IN cord-006824-btcdjmfp 94 58 chest chest NN cord-006824-btcdjmfp 94 59 syndrome syndrome NN cord-006824-btcdjmfp 94 60 and and CC cord-006824-btcdjmfp 94 61 pulmonary pulmonary JJ cord-006824-btcdjmfp 94 62 infarction infarction NN cord-006824-btcdjmfp 94 63 , , , cord-006824-btcdjmfp 94 64 severe severe JJ cord-006824-btcdjmfp 94 65 combined combine VBN cord-006824-btcdjmfp 94 66 immunodeficiency immunodeficiency NN cord-006824-btcdjmfp 94 67 with with IN cord-006824-btcdjmfp 94 68 recurrent recurrent JJ cord-006824-btcdjmfp 94 69 episodes episode NNS cord-006824-btcdjmfp 94 70 of of IN cord-006824-btcdjmfp 94 71 pneumonia pneumonia NN cord-006824-btcdjmfp 94 72 ) ) -RRB- cord-006824-btcdjmfp 94 73 , , , cord-006824-btcdjmfp 94 74 to to IN cord-006824-btcdjmfp 94 75 the the DT cord-006824-btcdjmfp 94 76 treatment treatment NN cord-006824-btcdjmfp 94 77 of of IN cord-006824-btcdjmfp 94 78 the the DT cord-006824-btcdjmfp 94 79 underlying underlie VBG cord-006824-btcdjmfp 94 80 disease disease NN cord-006824-btcdjmfp 94 81 ( ( -LRB- cord-006824-btcdjmfp 94 82 irradiation irradiation NN cord-006824-btcdjmfp 94 83 , , , cord-006824-btcdjmfp 94 84 resection resection NN cord-006824-btcdjmfp 94 85 ) ) -RRB- cord-006824-btcdjmfp 94 86 and and CC cord-006824-btcdjmfp 94 87 the the DT cord-006824-btcdjmfp 94 88 hyperimmune hyperimmune NNP cord-006824-btcdjmfp 94 89 status status NN cord-006824-btcdjmfp 94 90 ( ( -LRB- cord-006824-btcdjmfp 94 91 influenced influence VBN cord-006824-btcdjmfp 94 92 by by IN cord-006824-btcdjmfp 94 93 the the DT cord-006824-btcdjmfp 94 94 histocompatibility histocompatibility NN cord-006824-btcdjmfp 94 95 between between IN cord-006824-btcdjmfp 94 96 donor donor NN cord-006824-btcdjmfp 94 97 and and CC cord-006824-btcdjmfp 94 98 host host NN cord-006824-btcdjmfp 94 99 , , , cord-006824-btcdjmfp 94 100 e.g. e.g. RB cord-006824-btcdjmfp 94 101 donor donor NN cord-006824-btcdjmfp 94 102 T t NN cord-006824-btcdjmfp 94 103 - - HYPH cord-006824-btcdjmfp 94 104 cells cell NNS cord-006824-btcdjmfp 94 105 reacting react VBG cord-006824-btcdjmfp 94 106 to to IN cord-006824-btcdjmfp 94 107 HLAantigens HLAantigens NNP cord-006824-btcdjmfp 94 108 ) ) -RRB- cord-006824-btcdjmfp 94 109 . . . cord-006824-btcdjmfp 95 1 In in IN cord-006824-btcdjmfp 95 2 one one CD cord-006824-btcdjmfp 95 3 series series NN cord-006824-btcdjmfp 95 4 of of IN cord-006824-btcdjmfp 95 5 children child NNS cord-006824-btcdjmfp 95 6 undergoing undergo VBG cord-006824-btcdjmfp 95 7 transplantation transplantation NN cord-006824-btcdjmfp 95 8 for for IN cord-006824-btcdjmfp 95 9 hematologic hematologic JJ cord-006824-btcdjmfp 95 10 diseases disease NNS cord-006824-btcdjmfp 95 11 , , , cord-006824-btcdjmfp 95 12 44 44 CD cord-006824-btcdjmfp 95 13 % % NN cord-006824-btcdjmfp 95 14 had have VBD cord-006824-btcdjmfp 95 15 pulmonary pulmonary JJ cord-006824-btcdjmfp 95 16 function function NN cord-006824-btcdjmfp 95 17 abnormalities abnormality NNS cord-006824-btcdjmfp 95 18 before before IN cord-006824-btcdjmfp 95 19 the the DT cord-006824-btcdjmfp 95 20 procedure procedure NN cord-006824-btcdjmfp 95 21 ( ( -LRB- cord-006824-btcdjmfp 95 22 11 11 CD cord-006824-btcdjmfp 95 23 ) ) -RRB- cord-006824-btcdjmfp 95 24 . . . cord-006824-btcdjmfp 96 1 Although although IN cord-006824-btcdjmfp 96 2 the the DT cord-006824-btcdjmfp 96 3 topic topic NN cord-006824-btcdjmfp 96 4 of of IN cord-006824-btcdjmfp 96 5 this this DT cord-006824-btcdjmfp 96 6 review review NN cord-006824-btcdjmfp 96 7 is be VBZ cord-006824-btcdjmfp 96 8 non non JJ cord-006824-btcdjmfp 96 9 - - JJ cord-006824-btcdjmfp 96 10 infectious infectious JJ cord-006824-btcdjmfp 96 11 pulmonary pulmonary JJ cord-006824-btcdjmfp 96 12 complications complication NNS cord-006824-btcdjmfp 96 13 , , , cord-006824-btcdjmfp 96 14 it -PRON- PRP cord-006824-btcdjmfp 96 15 is be VBZ cord-006824-btcdjmfp 96 16 impossible impossible JJ cord-006824-btcdjmfp 96 17 to to TO cord-006824-btcdjmfp 96 18 completely completely RB cord-006824-btcdjmfp 96 19 distinguish distinguish VB cord-006824-btcdjmfp 96 20 these these DT cord-006824-btcdjmfp 96 21 from from IN cord-006824-btcdjmfp 96 22 infectious infectious JJ cord-006824-btcdjmfp 96 23 ones one NNS cord-006824-btcdjmfp 96 24 , , , cord-006824-btcdjmfp 96 25 as as IN cord-006824-btcdjmfp 96 26 the the DT cord-006824-btcdjmfp 96 27 latter latter JJ cord-006824-btcdjmfp 96 28 may may MD cord-006824-btcdjmfp 96 29 trigger trigger VB cord-006824-btcdjmfp 96 30 hyperimmune hyperimmune JJ cord-006824-btcdjmfp 96 31 reactions reaction NNS cord-006824-btcdjmfp 96 32 , , , cord-006824-btcdjmfp 96 33 lead lead VBP cord-006824-btcdjmfp 96 34 to to IN cord-006824-btcdjmfp 96 35 vascular vascular JJ cord-006824-btcdjmfp 96 36 alterations alteration NNS cord-006824-btcdjmfp 96 37 , , , cord-006824-btcdjmfp 96 38 enhance enhance VB cord-006824-btcdjmfp 96 39 antigen antigen NN cord-006824-btcdjmfp 96 40 presentation presentation NN cord-006824-btcdjmfp 96 41 and and CC cord-006824-btcdjmfp 96 42 fibroblast fibroblast NN cord-006824-btcdjmfp 96 43 activity activity NN cord-006824-btcdjmfp 96 44 , , , cord-006824-btcdjmfp 96 45 attract attract VBP cord-006824-btcdjmfp 96 46 neutrophils neutrophil NNS cord-006824-btcdjmfp 96 47 and and CC cord-006824-btcdjmfp 96 48 eosinophils eosinophil NNS cord-006824-btcdjmfp 96 49 with with IN cord-006824-btcdjmfp 96 50 release release NN cord-006824-btcdjmfp 96 51 of of IN cord-006824-btcdjmfp 96 52 their -PRON- PRP$ cord-006824-btcdjmfp 96 53 toxic toxic JJ cord-006824-btcdjmfp 96 54 products product NNS cord-006824-btcdjmfp 96 55 and and CC cord-006824-btcdjmfp 96 56 disturb disturb VB cord-006824-btcdjmfp 96 57 the the DT cord-006824-btcdjmfp 96 58 level level NN cord-006824-btcdjmfp 96 59 of of IN cord-006824-btcdjmfp 96 60 immunotolerance immunotolerance NN cord-006824-btcdjmfp 96 61 . . . cord-006824-btcdjmfp 97 1 In in IN cord-006824-btcdjmfp 97 2 contrast contrast NN cord-006824-btcdjmfp 97 3 , , , cord-006824-btcdjmfp 97 4 augmented augment VBN cord-006824-btcdjmfp 97 5 immunosuppression immunosuppression NN cord-006824-btcdjmfp 97 6 in in IN cord-006824-btcdjmfp 97 7 the the DT cord-006824-btcdjmfp 97 8 course course NN cord-006824-btcdjmfp 97 9 of of IN cord-006824-btcdjmfp 97 10 interstitial interstitial JJ cord-006824-btcdjmfp 97 11 lung lung NN cord-006824-btcdjmfp 97 12 disease disease NN cord-006824-btcdjmfp 97 13 enhances enhance VBZ cord-006824-btcdjmfp 97 14 the the DT cord-006824-btcdjmfp 97 15 susceptibility susceptibility NN cord-006824-btcdjmfp 97 16 for for IN cord-006824-btcdjmfp 97 17 infections infection NNS cord-006824-btcdjmfp 97 18 leading lead VBG cord-006824-btcdjmfp 97 19 to to IN cord-006824-btcdjmfp 97 20 additional additional JJ cord-006824-btcdjmfp 97 21 damage damage NN cord-006824-btcdjmfp 97 22 . . . cord-006824-btcdjmfp 98 1 The the DT cord-006824-btcdjmfp 98 2 extent extent NN cord-006824-btcdjmfp 98 3 of of IN cord-006824-btcdjmfp 98 4 pulmonary pulmonary JJ cord-006824-btcdjmfp 98 5 mortality mortality NN cord-006824-btcdjmfp 98 6 and and CC cord-006824-btcdjmfp 98 7 morbidity morbidity NN cord-006824-btcdjmfp 98 8 , , , cord-006824-btcdjmfp 98 9 the the DT cord-006824-btcdjmfp 98 10 degree degree NN cord-006824-btcdjmfp 98 11 and and CC cord-006824-btcdjmfp 98 12 the the DT cord-006824-btcdjmfp 98 13 spectrum spectrum NN cord-006824-btcdjmfp 98 14 of of IN cord-006824-btcdjmfp 98 15 pulmonary pulmonary JJ cord-006824-btcdjmfp 98 16 diseases disease NNS cord-006824-btcdjmfp 98 17 in in IN cord-006824-btcdjmfp 98 18 children child NNS cord-006824-btcdjmfp 98 19 as as RB cord-006824-btcdjmfp 98 20 well well RB cord-006824-btcdjmfp 98 21 as as IN cord-006824-btcdjmfp 98 22 the the DT cord-006824-btcdjmfp 98 23 relevance relevance NN cord-006824-btcdjmfp 98 24 of of IN cord-006824-btcdjmfp 98 25 possible possible JJ cord-006824-btcdjmfp 98 26 monocausal monocausal NN cord-006824-btcdjmfp 98 27 or or CC cord-006824-btcdjmfp 98 28 multifactorial multifactorial JJ cord-006824-btcdjmfp 98 29 etiologic etiologic JJ cord-006824-btcdjmfp 98 30 risk risk NN cord-006824-btcdjmfp 98 31 factors factor NNS cord-006824-btcdjmfp 98 32 ( ( -LRB- cord-006824-btcdjmfp 98 33 GVH gvh NN cord-006824-btcdjmfp 98 34 - - HYPH cord-006824-btcdjmfp 98 35 disease disease NN cord-006824-btcdjmfp 98 36 , , , cord-006824-btcdjmfp 98 37 irradiation irradiation NN cord-006824-btcdjmfp 98 38 , , , cord-006824-btcdjmfp 98 39 chemotherapy chemotherapy NN cord-006824-btcdjmfp 98 40 especially especially RB cord-006824-btcdjmfp 98 41 with with IN cord-006824-btcdjmfp 98 42 cyclophosphamide cyclophosphamide NN cord-006824-btcdjmfp 98 43 , , , cord-006824-btcdjmfp 98 44 bleomycin bleomycin NN cord-006824-btcdjmfp 98 45 , , , cord-006824-btcdjmfp 98 46 busulfane busulfane NNP cord-006824-btcdjmfp 98 47 , , , cord-006824-btcdjmfp 98 48 melphalane melphalane NNP cord-006824-btcdjmfp 98 49 ) ) -RRB- cord-006824-btcdjmfp 98 50 is be VBZ cord-006824-btcdjmfp 98 51 still still RB cord-006824-btcdjmfp 98 52 classified classify VBN cord-006824-btcdjmfp 98 53 insufficiently insufficiently RB cord-006824-btcdjmfp 98 54 [ [ -LRB- cord-006824-btcdjmfp 98 55 26 26 CD cord-006824-btcdjmfp 98 56 , , , cord-006824-btcdjmfp 98 57 52 52 CD cord-006824-btcdjmfp 98 58 , , , cord-006824-btcdjmfp 98 59 8 8 CD cord-006824-btcdjmfp 98 60 , , , cord-006824-btcdjmfp 98 61 17 17 CD cord-006824-btcdjmfp 98 62 , , , cord-006824-btcdjmfp 98 63 3 3 CD cord-006824-btcdjmfp 98 64 ] ] -RRB- cord-006824-btcdjmfp 98 65 . . . cord-006824-btcdjmfp 99 1 The the DT cord-006824-btcdjmfp 99 2 introduction introduction NN cord-006824-btcdjmfp 99 3 of of IN cord-006824-btcdjmfp 99 4 fractional fractional JJ cord-006824-btcdjmfp 99 5 irradiation irradiation NN cord-006824-btcdjmfp 99 6 schedules schedule NNS cord-006824-btcdjmfp 99 7 has have VBZ cord-006824-btcdjmfp 99 8 led lead VBN cord-006824-btcdjmfp 99 9 to to IN cord-006824-btcdjmfp 99 10 a a DT cord-006824-btcdjmfp 99 11 reduction reduction NN cord-006824-btcdjmfp 99 12 of of IN cord-006824-btcdjmfp 99 13 the the DT cord-006824-btcdjmfp 99 14 incidence incidence NN cord-006824-btcdjmfp 99 15 of of IN cord-006824-btcdjmfp 99 16 interstitial interstitial JJ cord-006824-btcdjmfp 99 17 pneumonia pneumonia NN cord-006824-btcdjmfp 99 18 [ [ -LRB- cord-006824-btcdjmfp 99 19 17 17 CD cord-006824-btcdjmfp 99 20 ] ] -RRB- cord-006824-btcdjmfp 99 21 . . . cord-006824-btcdjmfp 100 1 Latent latent JJ cord-006824-btcdjmfp 100 2 viral viral JJ cord-006824-btcdjmfp 100 3 infections infection NNS cord-006824-btcdjmfp 100 4 , , , cord-006824-btcdjmfp 100 5 GVHD GVHD NNP cord-006824-btcdjmfp 100 6 and and CC cord-006824-btcdjmfp 100 7 cytotoxic cytotoxic JJ cord-006824-btcdjmfp 100 8 factors factor NNS cord-006824-btcdjmfp 100 9 are be VBP cord-006824-btcdjmfp 100 10 not not RB cord-006824-btcdjmfp 100 11 well well RB cord-006824-btcdjmfp 100 12 defined define VBN cord-006824-btcdjmfp 100 13 in in IN cord-006824-btcdjmfp 100 14 their -PRON- PRP$ cord-006824-btcdjmfp 100 15 pathogenetic pathogenetic JJ cord-006824-btcdjmfp 100 16 role role NN cord-006824-btcdjmfp 100 17 and and CC cord-006824-btcdjmfp 100 18 S11 S11 NNP cord-006824-btcdjmfp 100 19 data datum NNS cord-006824-btcdjmfp 100 20 about about IN cord-006824-btcdjmfp 100 21 the the DT cord-006824-btcdjmfp 100 22 influence influence NN cord-006824-btcdjmfp 100 23 of of IN cord-006824-btcdjmfp 100 24 fungi fungus NNS cord-006824-btcdjmfp 100 25 is be VBZ cord-006824-btcdjmfp 100 26 limited limit VBN cord-006824-btcdjmfp 100 27 [ [ -LRB- cord-006824-btcdjmfp 100 28 5 5 CD cord-006824-btcdjmfp 100 29 , , , cord-006824-btcdjmfp 100 30 20 20 CD cord-006824-btcdjmfp 100 31 , , , cord-006824-btcdjmfp 100 32 13 13 CD cord-006824-btcdjmfp 100 33 ] ] -RRB- cord-006824-btcdjmfp 100 34 . . . cord-006824-btcdjmfp 101 1 Histologic Histologic NNP cord-006824-btcdjmfp 101 2 evaluations evaluation NNS cord-006824-btcdjmfp 101 3 of of IN cord-006824-btcdjmfp 101 4 lung lung NN cord-006824-btcdjmfp 101 5 tissue tissue NN cord-006824-btcdjmfp 101 6 in in IN cord-006824-btcdjmfp 101 7 GVHD GVHD NNP cord-006824-btcdjmfp 101 8 - - HYPH cord-006824-btcdjmfp 101 9 patients patient NNS cord-006824-btcdjmfp 101 10 show show VBP cord-006824-btcdjmfp 101 11 epithelial epithelial JJ cord-006824-btcdjmfp 101 12 and and CC cord-006824-btcdjmfp 101 13 interstitial interstitial JJ cord-006824-btcdjmfp 101 14 lesions lesion NNS cord-006824-btcdjmfp 101 15 typical typical JJ cord-006824-btcdjmfp 101 16 for for IN cord-006824-btcdjmfp 101 17 GVHD GVHD NNP cord-006824-btcdjmfp 101 18 of of IN cord-006824-btcdjmfp 101 19 the the DT cord-006824-btcdjmfp 101 20 skin skin NN cord-006824-btcdjmfp 101 21 and and CC cord-006824-btcdjmfp 101 22 the the DT cord-006824-btcdjmfp 101 23 intestine intestine NN cord-006824-btcdjmfp 101 24 [ [ -LRB- cord-006824-btcdjmfp 101 25 83 83 CD cord-006824-btcdjmfp 101 26 ] ] -RRB- cord-006824-btcdjmfp 101 27 . . . cord-006824-btcdjmfp 102 1 There there EX cord-006824-btcdjmfp 102 2 is be VBZ cord-006824-btcdjmfp 102 3 some some DT cord-006824-btcdjmfp 102 4 evidence evidence NN cord-006824-btcdjmfp 102 5 for for IN cord-006824-btcdjmfp 102 6 an an DT cord-006824-btcdjmfp 102 7 active active JJ cord-006824-btcdjmfp 102 8 role role NN cord-006824-btcdjmfp 102 9 of of IN cord-006824-btcdjmfp 102 10 CMV CMV NNP cord-006824-btcdjmfp 102 11 in in IN cord-006824-btcdjmfp 102 12 bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 102 13 obliterans obliterans NNP cord-006824-btcdjmfp 102 14 ( ( -LRB- cord-006824-btcdjmfp 102 15 BO BO NNP cord-006824-btcdjmfp 102 16 ) ) -RRB- cord-006824-btcdjmfp 102 17 as as RB cord-006824-btcdjmfp 102 18 well well RB cord-006824-btcdjmfp 102 19 as as IN cord-006824-btcdjmfp 102 20 in in IN cord-006824-btcdjmfp 102 21 interstitial interstitial JJ cord-006824-btcdjmfp 102 22 pneumonias pneumonia NNS cord-006824-btcdjmfp 102 23 . . . cord-006824-btcdjmfp 103 1 Since since IN cord-006824-btcdjmfp 103 2 the the DT cord-006824-btcdjmfp 103 3 detection detection NN cord-006824-btcdjmfp 103 4 of of IN cord-006824-btcdjmfp 103 5 CMV CMV NNP cord-006824-btcdjmfp 103 6 in in IN cord-006824-btcdjmfp 103 7 bronchoalveolar bronchoalveolar NNP cord-006824-btcdjmfp 103 8 lavage lavage NNP cord-006824-btcdjmfp 103 9 ( ( -LRB- cord-006824-btcdjmfp 103 10 BAL BAL NNP cord-006824-btcdjmfp 103 11 ) ) -RRB- cord-006824-btcdjmfp 103 12 can can MD cord-006824-btcdjmfp 103 13 be be VB cord-006824-btcdjmfp 103 14 taken take VBN cord-006824-btcdjmfp 103 15 as as IN cord-006824-btcdjmfp 103 16 an an DT cord-006824-btcdjmfp 103 17 indicator indicator NN cord-006824-btcdjmfp 103 18 of of IN cord-006824-btcdjmfp 103 19 invasive invasive JJ cord-006824-btcdjmfp 103 20 infection infection NN cord-006824-btcdjmfp 103 21 [ [ -LRB- cord-006824-btcdjmfp 103 22 9 9 CD cord-006824-btcdjmfp 103 23 , , , cord-006824-btcdjmfp 103 24 69 69 CD cord-006824-btcdjmfp 103 25 , , , cord-006824-btcdjmfp 103 26 63 63 CD cord-006824-btcdjmfp 103 27 ] ] -RRB- cord-006824-btcdjmfp 103 28 , , , cord-006824-btcdjmfp 103 29 screening screen VBG cord-006824-btcdjmfp 103 30 for for IN cord-006824-btcdjmfp 103 31 CMV CMV NNP cord-006824-btcdjmfp 103 32 in in IN cord-006824-btcdjmfp 103 33 BAL bal NN cord-006824-btcdjmfp 103 34 and and CC cord-006824-btcdjmfp 103 35 blood blood NN cord-006824-btcdjmfp 103 36 has have VBZ cord-006824-btcdjmfp 103 37 been be VBN cord-006824-btcdjmfp 103 38 suggested suggest VBN cord-006824-btcdjmfp 103 39 as as IN cord-006824-btcdjmfp 103 40 a a DT cord-006824-btcdjmfp 103 41 basis basis NN cord-006824-btcdjmfp 103 42 for for IN cord-006824-btcdjmfp 103 43 rigorous rigorous JJ cord-006824-btcdjmfp 103 44 treatment treatment NN cord-006824-btcdjmfp 103 45 [ [ -LRB- cord-006824-btcdjmfp 103 46 38 38 CD cord-006824-btcdjmfp 103 47 , , , cord-006824-btcdjmfp 103 48 1 1 CD cord-006824-btcdjmfp 103 49 , , , cord-006824-btcdjmfp 103 50 30 30 CD cord-006824-btcdjmfp 103 51 , , , cord-006824-btcdjmfp 103 52 39 39 CD cord-006824-btcdjmfp 103 53 , , , cord-006824-btcdjmfp 103 54 25 25 CD cord-006824-btcdjmfp 103 55 ] ] -RRB- cord-006824-btcdjmfp 103 56 . . . cord-006824-btcdjmfp 104 1 The the DT cord-006824-btcdjmfp 104 2 same same JJ cord-006824-btcdjmfp 104 3 may may MD cord-006824-btcdjmfp 104 4 hold hold VB cord-006824-btcdjmfp 104 5 true true JJ cord-006824-btcdjmfp 104 6 for for IN cord-006824-btcdjmfp 104 7 other other JJ cord-006824-btcdjmfp 104 8 viruses virus NNS cord-006824-btcdjmfp 104 9 such such JJ cord-006824-btcdjmfp 104 10 as as IN cord-006824-btcdjmfp 104 11 adeno- adeno- NN cord-006824-btcdjmfp 104 12 , , , cord-006824-btcdjmfp 104 13 EBV EBV NNP cord-006824-btcdjmfp 104 14 , , , cord-006824-btcdjmfp 104 15 influenza influenza NN cord-006824-btcdjmfp 104 16 , , , cord-006824-btcdjmfp 104 17 parainfluenza parainfluenza NNP cord-006824-btcdjmfp 104 18 virus virus NN cord-006824-btcdjmfp 104 19 , , , cord-006824-btcdjmfp 104 20 HHV-6 HHV-6 NNP cord-006824-btcdjmfp 104 21 and and CC cord-006824-btcdjmfp 104 22 RSV RSV NNP cord-006824-btcdjmfp 104 23 ( ( -LRB- cord-006824-btcdjmfp 104 24 75 75 CD cord-006824-btcdjmfp 104 25 , , , cord-006824-btcdjmfp 104 26 34 34 CD cord-006824-btcdjmfp 104 27 ) ) -RRB- cord-006824-btcdjmfp 104 28 . . . cord-006824-btcdjmfp 105 1 It -PRON- PRP cord-006824-btcdjmfp 105 2 is be VBZ cord-006824-btcdjmfp 105 3 usual usual JJ cord-006824-btcdjmfp 105 4 to to TO cord-006824-btcdjmfp 105 5 separate separate JJ cord-006824-btcdjmfp 105 6 pulmonary pulmonary JJ cord-006824-btcdjmfp 105 7 complications complication NNS cord-006824-btcdjmfp 105 8 up up IN cord-006824-btcdjmfp 105 9 to to IN cord-006824-btcdjmfp 105 10 day day NN cord-006824-btcdjmfp 105 11 100 100 CD cord-006824-btcdjmfp 105 12 ( ( -LRB- cord-006824-btcdjmfp 105 13 early early RB cord-006824-btcdjmfp 105 14 ) ) -RRB- cord-006824-btcdjmfp 105 15 from from IN cord-006824-btcdjmfp 105 16 those those DT cord-006824-btcdjmfp 105 17 after after IN cord-006824-btcdjmfp 105 18 day day NN cord-006824-btcdjmfp 105 19 100 100 CD cord-006824-btcdjmfp 105 20 ( ( -LRB- cord-006824-btcdjmfp 105 21 late late JJ cord-006824-btcdjmfp 105 22 ) ) -RRB- cord-006824-btcdjmfp 105 23 , , , cord-006824-btcdjmfp 105 24 although although IN cord-006824-btcdjmfp 105 25 for for IN cord-006824-btcdjmfp 105 26 some some DT cord-006824-btcdjmfp 105 27 risks risk NNS cord-006824-btcdjmfp 105 28 the the DT cord-006824-btcdjmfp 105 29 division division NN cord-006824-btcdjmfp 105 30 is be VBZ cord-006824-btcdjmfp 105 31 arbitrary arbitrary JJ cord-006824-btcdjmfp 105 32 . . . cord-006824-btcdjmfp 106 1 If if IN cord-006824-btcdjmfp 106 2 one one PRP cord-006824-btcdjmfp 106 3 follows follow VBZ cord-006824-btcdjmfp 106 4 lung lung NN cord-006824-btcdjmfp 106 5 function function NN cord-006824-btcdjmfp 106 6 parameters parameter NNS cord-006824-btcdjmfp 106 7 over over IN cord-006824-btcdjmfp 106 8 time time NN cord-006824-btcdjmfp 106 9 in in IN cord-006824-btcdjmfp 106 10 clinically clinically RB cord-006824-btcdjmfp 106 11 asyptomatic asyptomatic JJ cord-006824-btcdjmfp 106 12 patients patient NNS cord-006824-btcdjmfp 106 13 after after IN cord-006824-btcdjmfp 106 14 HSCT HSCT NNP cord-006824-btcdjmfp 106 15 for for IN cord-006824-btcdjmfp 106 16 childhood childhood NN cord-006824-btcdjmfp 106 17 leukemia leukemia NN cord-006824-btcdjmfp 106 18 [ [ -LRB- cord-006824-btcdjmfp 106 19 11 11 CD cord-006824-btcdjmfp 106 20 ] ] -RRB- cord-006824-btcdjmfp 106 21 , , , cord-006824-btcdjmfp 106 22 abnormalities abnormality NNS cord-006824-btcdjmfp 106 23 can can MD cord-006824-btcdjmfp 106 24 be be VB cord-006824-btcdjmfp 106 25 observed observe VBN cord-006824-btcdjmfp 106 26 in in IN cord-006824-btcdjmfp 106 27 more more JJR cord-006824-btcdjmfp 106 28 than than IN cord-006824-btcdjmfp 106 29 80 80 CD cord-006824-btcdjmfp 106 30 % % NN cord-006824-btcdjmfp 106 31 of of IN cord-006824-btcdjmfp 106 32 patients patient NNS cord-006824-btcdjmfp 106 33 with with IN cord-006824-btcdjmfp 106 34 predominance predominance NN cord-006824-btcdjmfp 106 35 of of IN cord-006824-btcdjmfp 106 36 a a DT cord-006824-btcdjmfp 106 37 restrictive restrictive JJ cord-006824-btcdjmfp 106 38 pattern pattern NN cord-006824-btcdjmfp 106 39 6 6 CD cord-006824-btcdjmfp 106 40 months month NNS cord-006824-btcdjmfp 106 41 after after IN cord-006824-btcdjmfp 106 42 transplantation transplantation NN cord-006824-btcdjmfp 106 43 ( ( -LRB- cord-006824-btcdjmfp 106 44 possibly possibly RB cord-006824-btcdjmfp 106 45 due due JJ cord-006824-btcdjmfp 106 46 to to IN cord-006824-btcdjmfp 106 47 conditioning conditioning NN cord-006824-btcdjmfp 106 48 ) ) -RRB- cord-006824-btcdjmfp 106 49 . . . cord-006824-btcdjmfp 107 1 Lung lung NN cord-006824-btcdjmfp 107 2 function function NN cord-006824-btcdjmfp 107 3 abnormalities abnormality NNS cord-006824-btcdjmfp 107 4 tend tend VBP cord-006824-btcdjmfp 107 5 to to TO cord-006824-btcdjmfp 107 6 persist persist VB cord-006824-btcdjmfp 107 7 in in IN cord-006824-btcdjmfp 107 8 patients patient NNS cord-006824-btcdjmfp 107 9 with with IN cord-006824-btcdjmfp 107 10 advanced advanced JJ cord-006824-btcdjmfp 107 11 disease disease NN cord-006824-btcdjmfp 107 12 states state NNS cord-006824-btcdjmfp 107 13 before before IN cord-006824-btcdjmfp 107 14 transplantation transplantation NN cord-006824-btcdjmfp 107 15 but but CC cord-006824-btcdjmfp 107 16 decrease decrease NN cord-006824-btcdjmfp 107 17 by by IN cord-006824-btcdjmfp 107 18 50 50 CD cord-006824-btcdjmfp 107 19 % % NN cord-006824-btcdjmfp 107 20 in in IN cord-006824-btcdjmfp 107 21 those those DT cord-006824-btcdjmfp 107 22 with with IN cord-006824-btcdjmfp 107 23 transplantation transplantation NN cord-006824-btcdjmfp 107 24 at at IN cord-006824-btcdjmfp 107 25 early early JJ cord-006824-btcdjmfp 107 26 stages stage NNS cord-006824-btcdjmfp 107 27 of of IN cord-006824-btcdjmfp 107 28 childhood childhood NN cord-006824-btcdjmfp 107 29 leukemia leukemia NN cord-006824-btcdjmfp 107 30 , , , cord-006824-btcdjmfp 107 31 suggesting suggest VBG cord-006824-btcdjmfp 107 32 a a DT cord-006824-btcdjmfp 107 33 summation summation NN cord-006824-btcdjmfp 107 34 of of IN cord-006824-btcdjmfp 107 35 adverse adverse JJ cord-006824-btcdjmfp 107 36 effects effect NNS cord-006824-btcdjmfp 107 37 . . . cord-006824-btcdjmfp 108 1 Toxic toxic JJ cord-006824-btcdjmfp 108 2 pulmonary pulmonary JJ cord-006824-btcdjmfp 108 3 reactions reaction NNS cord-006824-btcdjmfp 108 4 may may MD cord-006824-btcdjmfp 108 5 occur occur VB cord-006824-btcdjmfp 108 6 within within IN cord-006824-btcdjmfp 108 7 90 90 CD cord-006824-btcdjmfp 108 8 days day NNS cord-006824-btcdjmfp 108 9 after after IN cord-006824-btcdjmfp 108 10 irradiation irradiation NN cord-006824-btcdjmfp 108 11 . . . cord-006824-btcdjmfp 109 1 Clinically clinically RB cord-006824-btcdjmfp 109 2 overt overt JJ cord-006824-btcdjmfp 109 3 non non JJ cord-006824-btcdjmfp 109 4 - - JJ cord-006824-btcdjmfp 109 5 infectious infectious JJ cord-006824-btcdjmfp 109 6 pulmonary pulmonary JJ cord-006824-btcdjmfp 109 7 complications complication NNS cord-006824-btcdjmfp 109 8 in in IN cord-006824-btcdjmfp 109 9 the the DT cord-006824-btcdjmfp 109 10 neutropenic neutropenic JJ cord-006824-btcdjmfp 109 11 ( ( -LRB- cord-006824-btcdjmfp 109 12 early early JJ cord-006824-btcdjmfp 109 13 ) ) -RRB- cord-006824-btcdjmfp 109 14 phase phase NN cord-006824-btcdjmfp 109 15 after after IN cord-006824-btcdjmfp 109 16 transplantation transplantation NN cord-006824-btcdjmfp 109 17 occur occur VBP cord-006824-btcdjmfp 109 18 in in IN cord-006824-btcdjmfp 109 19 the the DT cord-006824-btcdjmfp 109 20 form form NN cord-006824-btcdjmfp 109 21 of of IN cord-006824-btcdjmfp 109 22 engraftment engraftment NN cord-006824-btcdjmfp 109 23 - - HYPH cord-006824-btcdjmfp 109 24 syndrome syndrome NN cord-006824-btcdjmfp 109 25 , , , cord-006824-btcdjmfp 109 26 idiopathic idiopathic JJ cord-006824-btcdjmfp 109 27 pneumonia pneumonia NN cord-006824-btcdjmfp 109 28 syndrome syndrome NN cord-006824-btcdjmfp 109 29 ( ( -LRB- cord-006824-btcdjmfp 109 30 IPS IPS NNP cord-006824-btcdjmfp 109 31 ) ) -RRB- cord-006824-btcdjmfp 109 32 or or CC cord-006824-btcdjmfp 109 33 diffuse diffuse VB cord-006824-btcdjmfp 109 34 alveolar alveolar NN cord-006824-btcdjmfp 109 35 hemorrhagesyndrome hemorrhagesyndrome NNP cord-006824-btcdjmfp 109 36 ( ( -LRB- cord-006824-btcdjmfp 109 37 DAH DAH NNP cord-006824-btcdjmfp 109 38 ) ) -RRB- cord-006824-btcdjmfp 109 39 . . . cord-006824-btcdjmfp 110 1 Furthermore furthermore RB cord-006824-btcdjmfp 110 2 the the DT cord-006824-btcdjmfp 110 3 lung lung NN cord-006824-btcdjmfp 110 4 can can MD cord-006824-btcdjmfp 110 5 be be VB cord-006824-btcdjmfp 110 6 part part NN cord-006824-btcdjmfp 110 7 of of IN cord-006824-btcdjmfp 110 8 a a DT cord-006824-btcdjmfp 110 9 systemic systemic JJ cord-006824-btcdjmfp 110 10 vascular vascular JJ cord-006824-btcdjmfp 110 11 process process NN cord-006824-btcdjmfp 110 12 ( ( -LRB- cord-006824-btcdjmfp 110 13 capillary capillary JJ cord-006824-btcdjmfp 110 14 - - HYPH cord-006824-btcdjmfp 110 15 leak leak NN cord-006824-btcdjmfp 110 16 - - HYPH cord-006824-btcdjmfp 110 17 syndrome syndrome NN cord-006824-btcdjmfp 110 18 , , , cord-006824-btcdjmfp 110 19 thrombotic thrombotic JJ cord-006824-btcdjmfp 110 20 - - HYPH cord-006824-btcdjmfp 110 21 thrombocytopenic thrombocytopenic JJ cord-006824-btcdjmfp 110 22 purpura purpura NN cord-006824-btcdjmfp 110 23 or or CC cord-006824-btcdjmfp 110 24 cytokine cytokine NN cord-006824-btcdjmfp 110 25 - - HYPH cord-006824-btcdjmfp 110 26 syndrome syndrome NN cord-006824-btcdjmfp 110 27 ) ) -RRB- cord-006824-btcdjmfp 110 28 . . . cord-006824-btcdjmfp 111 1 Late late JJ cord-006824-btcdjmfp 111 2 pulmonary pulmonary JJ cord-006824-btcdjmfp 111 3 sequelae sequela NNS cord-006824-btcdjmfp 111 4 manifest manifest VBP cord-006824-btcdjmfp 111 5 as as IN cord-006824-btcdjmfp 111 6 bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 111 7 obliterans obliterans NNP cord-006824-btcdjmfp 111 8 ( ( -LRB- cord-006824-btcdjmfp 111 9 BO BO NNP cord-006824-btcdjmfp 111 10 ) ) -RRB- cord-006824-btcdjmfp 111 11 , , , cord-006824-btcdjmfp 111 12 bronchiolitis bronchiolitis NNP cord-006824-btcdjmfp 111 13 obliterans obliterans NNP cord-006824-btcdjmfp 111 14 organizing organize VBG cord-006824-btcdjmfp 111 15 pneumonia pneumonia NN cord-006824-btcdjmfp 111 16 ( ( -LRB- cord-006824-btcdjmfp 111 17 BOOP BOOP NNP cord-006824-btcdjmfp 111 18 ) ) -RRB- cord-006824-btcdjmfp 111 19 or or CC cord-006824-btcdjmfp 111 20 fibrosis fibrosis NN cord-006824-btcdjmfp 111 21 . . . cord-006824-btcdjmfp 112 1 There there EX cord-006824-btcdjmfp 112 2 are be VBP cord-006824-btcdjmfp 112 3 several several JJ cord-006824-btcdjmfp 112 4 distinct distinct JJ cord-006824-btcdjmfp 112 5 cellular cellular JJ cord-006824-btcdjmfp 112 6 systems system NNS cord-006824-btcdjmfp 112 7 involved involve VBN cord-006824-btcdjmfp 112 8 in in IN cord-006824-btcdjmfp 112 9 the the DT cord-006824-btcdjmfp 112 10 maintenance maintenance NN cord-006824-btcdjmfp 112 11 of of IN cord-006824-btcdjmfp 112 12 pulmonary pulmonary JJ cord-006824-btcdjmfp 112 13 integrity integrity NN cord-006824-btcdjmfp 112 14 and and CC cord-006824-btcdjmfp 112 15 , , , cord-006824-btcdjmfp 112 16 accordingly accordingly RB cord-006824-btcdjmfp 112 17 , , , cord-006824-btcdjmfp 112 18 in in IN cord-006824-btcdjmfp 112 19 the the DT cord-006824-btcdjmfp 112 20 disease disease NN cord-006824-btcdjmfp 112 21 process process NN cord-006824-btcdjmfp 112 22 : : : cord-006824-btcdjmfp 112 23 ( ( -LRB- cord-006824-btcdjmfp 112 24 a a DT cord-006824-btcdjmfp 112 25 ) ) -RRB- cord-006824-btcdjmfp 112 26 Alveolar alveolar NN cord-006824-btcdjmfp 112 27 cells cell NNS cord-006824-btcdjmfp 112 28 or or CC cord-006824-btcdjmfp 112 29 pneumocytes pneumocyte NNS cord-006824-btcdjmfp 112 30 are be VBP cord-006824-btcdjmfp 112 31 a a DT cord-006824-btcdjmfp 112 32 source source NN cord-006824-btcdjmfp 112 33 of of IN cord-006824-btcdjmfp 112 34 surfactant surfactant NN cord-006824-btcdjmfp 112 35 and and CC cord-006824-btcdjmfp 112 36 contribute contribute VB cord-006824-btcdjmfp 112 37 to to IN cord-006824-btcdjmfp 112 38 metabolism metabolism NN cord-006824-btcdjmfp 112 39 within within IN cord-006824-btcdjmfp 112 40 the the DT cord-006824-btcdjmfp 112 41 lung lung NN cord-006824-btcdjmfp 112 42 as as RB cord-006824-btcdjmfp 112 43 well well RB cord-006824-btcdjmfp 112 44 as as IN cord-006824-btcdjmfp 112 45 to to IN cord-006824-btcdjmfp 112 46 lung lung NN cord-006824-btcdjmfp 112 47 defence defence NN cord-006824-btcdjmfp 112 48 . . . cord-006824-btcdjmfp 113 1 ( ( -LRB- cord-006824-btcdjmfp 113 2 b b LS cord-006824-btcdjmfp 113 3 ) ) -RRB- cord-006824-btcdjmfp 113 4 Bronchial bronchial JJ cord-006824-btcdjmfp 113 5 epithelial epithelial JJ cord-006824-btcdjmfp 113 6 cells cell NNS cord-006824-btcdjmfp 113 7 contribute contribute VBP cord-006824-btcdjmfp 113 8 to to IN cord-006824-btcdjmfp 113 9 the the DT cord-006824-btcdjmfp 113 10 clearance clearance NN cord-006824-btcdjmfp 113 11 of of IN cord-006824-btcdjmfp 113 12 bacteria bacteria NNS cord-006824-btcdjmfp 113 13 and and CC cord-006824-btcdjmfp 113 14 are be VBP cord-006824-btcdjmfp 113 15 important important JJ cord-006824-btcdjmfp 113 16 barriers barrier NNS cord-006824-btcdjmfp 113 17 against against IN cord-006824-btcdjmfp 113 18 invasion invasion NN cord-006824-btcdjmfp 113 19 . . . cord-006824-btcdjmfp 114 1 ( ( -LRB- cord-006824-btcdjmfp 114 2 c c NN cord-006824-btcdjmfp 114 3 ) ) -RRB- cord-006824-btcdjmfp 114 4 Vascular vascular JJ cord-006824-btcdjmfp 114 5 endothelial endothelial JJ cord-006824-btcdjmfp 114 6 cells cell NNS cord-006824-btcdjmfp 114 7 are be VBP cord-006824-btcdjmfp 114 8 essential essential JJ cord-006824-btcdjmfp 114 9 for for IN cord-006824-btcdjmfp 114 10 regulating regulate VBG cord-006824-btcdjmfp 114 11 gas gas NN cord-006824-btcdjmfp 114 12 exchange exchange NN cord-006824-btcdjmfp 114 13 , , , cord-006824-btcdjmfp 114 14 fluid fluid JJ cord-006824-btcdjmfp 114 15 homeostasis homeostasis NN cord-006824-btcdjmfp 114 16 ( ( -LRB- cord-006824-btcdjmfp 114 17 selectins selectin NNS cord-006824-btcdjmfp 114 18 , , , cord-006824-btcdjmfp 114 19 endothelin endothelin NNP cord-006824-btcdjmfp 114 20 ) ) -RRB- cord-006824-btcdjmfp 114 21 , , , cord-006824-btcdjmfp 114 22 and and CC cord-006824-btcdjmfp 114 23 the the DT cord-006824-btcdjmfp 114 24 migration migration NN cord-006824-btcdjmfp 114 25 of of IN cord-006824-btcdjmfp 114 26 blood blood NN cord-006824-btcdjmfp 114 27 cells cell NNS cord-006824-btcdjmfp 114 28 . . . cord-006824-btcdjmfp 115 1 ( ( -LRB- cord-006824-btcdjmfp 115 2 d d LS cord-006824-btcdjmfp 115 3 ) ) -RRB- cord-006824-btcdjmfp 115 4 Fibroblasts fibroblast NNS cord-006824-btcdjmfp 115 5 are be VBP cord-006824-btcdjmfp 115 6 sources source NNS cord-006824-btcdjmfp 115 7 of of IN cord-006824-btcdjmfp 115 8 metalloproteinases metalloproteinase NNS cord-006824-btcdjmfp 115 9 and and CC cord-006824-btcdjmfp 115 10 contribute contribute VB cord-006824-btcdjmfp 115 11 to to IN cord-006824-btcdjmfp 115 12 the the DT cord-006824-btcdjmfp 115 13 repair repair NN cord-006824-btcdjmfp 115 14 ( ( -LRB- cord-006824-btcdjmfp 115 15 and and CC cord-006824-btcdjmfp 115 16 fibrotic fibrotic JJ cord-006824-btcdjmfp 115 17 changes change NNS cord-006824-btcdjmfp 115 18 ) ) -RRB- cord-006824-btcdjmfp 115 19 of of IN cord-006824-btcdjmfp 115 20 lung lung NN cord-006824-btcdjmfp 115 21 tissue tissue NN cord-006824-btcdjmfp 115 22 . . . cord-006824-btcdjmfp 116 1 ( ( -LRB- cord-006824-btcdjmfp 116 2 e e LS cord-006824-btcdjmfp 116 3 ) ) -RRB- cord-006824-btcdjmfp 116 4 Dendritic dendritic JJ cord-006824-btcdjmfp 116 5 cells cell NNS cord-006824-btcdjmfp 116 6 act act VBP cord-006824-btcdjmfp 116 7 as as IN cord-006824-btcdjmfp 116 8 antigen antigen NN cord-006824-btcdjmfp 116 9 - - HYPH cord-006824-btcdjmfp 116 10 presenting present VBG cord-006824-btcdjmfp 116 11 - - HYPH cord-006824-btcdjmfp 116 12 cells cell NNS cord-006824-btcdjmfp 116 13 . . . cord-006824-btcdjmfp 117 1 ( ( -LRB- cord-006824-btcdjmfp 117 2 f f LS cord-006824-btcdjmfp 117 3 ) ) -RRB- cord-006824-btcdjmfp 117 4 T T NNP cord-006824-btcdjmfp 117 5 - - HYPH cord-006824-btcdjmfp 117 6 cells cell NNS cord-006824-btcdjmfp 117 7 target target VBP cord-006824-btcdjmfp 117 8 pulmonary pulmonary JJ cord-006824-btcdjmfp 117 9 structures structure NNS cord-006824-btcdjmfp 117 10 in in IN cord-006824-btcdjmfp 117 11 GVHD GVHD NNP cord-006824-btcdjmfp 117 12 or or CC cord-006824-btcdjmfp 117 13 autoimmunity autoimmunity NN cord-006824-btcdjmfp 117 14 . . . cord-006824-btcdjmfp 118 1 ( ( -LRB- cord-006824-btcdjmfp 118 2 g g NN cord-006824-btcdjmfp 118 3 ) ) -RRB- cord-006824-btcdjmfp 118 4 Neutrophils Neutrophils NNP cord-006824-btcdjmfp 118 5 are be VBP cord-006824-btcdjmfp 118 6 the the DT cord-006824-btcdjmfp 118 7 leading lead VBG cord-006824-btcdjmfp 118 8 cells cell NNS cord-006824-btcdjmfp 118 9 in in IN cord-006824-btcdjmfp 118 10 bacterial bacterial JJ cord-006824-btcdjmfp 118 11 defense defense NN cord-006824-btcdjmfp 118 12 but but CC cord-006824-btcdjmfp 118 13 are be VBP cord-006824-btcdjmfp 118 14 also also RB cord-006824-btcdjmfp 118 15 sources source NNS cord-006824-btcdjmfp 118 16 of of IN cord-006824-btcdjmfp 118 17 proteases protease NNS cord-006824-btcdjmfp 118 18 with with IN cord-006824-btcdjmfp 118 19 strong strong JJ cord-006824-btcdjmfp 118 20 elastolytic elastolytic JJ cord-006824-btcdjmfp 118 21 activity activity NN cord-006824-btcdjmfp 118 22 . . . cord-006824-btcdjmfp 119 1 ( ( -LRB- cord-006824-btcdjmfp 119 2 h h NN cord-006824-btcdjmfp 119 3 ) ) -RRB- cord-006824-btcdjmfp 120 1 Recently recently RB cord-006824-btcdjmfp 120 2 a a DT cord-006824-btcdjmfp 120 3 role role NN cord-006824-btcdjmfp 120 4 has have VBZ cord-006824-btcdjmfp 120 5 been be VBN cord-006824-btcdjmfp 120 6 proposed propose VBN cord-006824-btcdjmfp 120 7 for for IN cord-006824-btcdjmfp 120 8 alveolar alveolar JJ cord-006824-btcdjmfp 120 9 macrophages macrophage NNS cord-006824-btcdjmfp 120 10 in in IN cord-006824-btcdjmfp 120 11 disease disease NN cord-006824-btcdjmfp 120 12 processes process NNS cord-006824-btcdjmfp 120 13 after after IN cord-006824-btcdjmfp 120 14 HSCT HSCT NNP cord-006824-btcdjmfp 120 15 ( ( -LRB- cord-006824-btcdjmfp 120 16 76 76 CD cord-006824-btcdjmfp 120 17 ) ) -RRB- cord-006824-btcdjmfp 120 18 . . . cord-006824-btcdjmfp 121 1 It -PRON- PRP cord-006824-btcdjmfp 121 2 is be VBZ cord-006824-btcdjmfp 121 3 beyond beyond IN cord-006824-btcdjmfp 121 4 the the DT cord-006824-btcdjmfp 121 5 scope scope NN cord-006824-btcdjmfp 121 6 of of IN cord-006824-btcdjmfp 121 7 this this DT cord-006824-btcdjmfp 121 8 review review NN cord-006824-btcdjmfp 121 9 to to TO cord-006824-btcdjmfp 121 10 evalute evalute VB cord-006824-btcdjmfp 121 11 the the DT cord-006824-btcdjmfp 121 12 literature literature NN cord-006824-btcdjmfp 121 13 on on IN cord-006824-btcdjmfp 121 14 the the DT cord-006824-btcdjmfp 121 15 spectrum spectrum NN cord-006824-btcdjmfp 121 16 of of IN cord-006824-btcdjmfp 121 17 immune immune JJ cord-006824-btcdjmfp 121 18 mechanisms mechanism NNS cord-006824-btcdjmfp 121 19 which which WDT cord-006824-btcdjmfp 121 20 include include VBP cord-006824-btcdjmfp 121 21 direct direct JJ cord-006824-btcdjmfp 121 22 and and CC cord-006824-btcdjmfp 121 23 indirect indirect JJ cord-006824-btcdjmfp 121 24 allorecognition allorecognition NN cord-006824-btcdjmfp 121 25 as as RB cord-006824-btcdjmfp 121 26 well well RB cord-006824-btcdjmfp 121 27 as as IN cord-006824-btcdjmfp 121 28 the the DT cord-006824-btcdjmfp 121 29 activation activation NN cord-006824-btcdjmfp 121 30 of of IN cord-006824-btcdjmfp 121 31 chemokines chemokine NNS cord-006824-btcdjmfp 121 32 and and CC cord-006824-btcdjmfp 121 33 lymphokines lymphokine NNS cord-006824-btcdjmfp 121 34 . . . cord-006824-btcdjmfp 122 1 Pulmonary pulmonary JJ cord-006824-btcdjmfp 122 2 diagnostics diagnostic NNS cord-006824-btcdjmfp 122 3 include include VBP cord-006824-btcdjmfp 122 4 lung lung NN cord-006824-btcdjmfp 122 5 function function NN cord-006824-btcdjmfp 122 6 testing testing NN cord-006824-btcdjmfp 122 7 ( ( -LRB- cord-006824-btcdjmfp 122 8 bedside bedside NN cord-006824-btcdjmfp 122 9 with with IN cord-006824-btcdjmfp 122 10 portable portable JJ cord-006824-btcdjmfp 122 11 spirometers spirometer NNS cord-006824-btcdjmfp 122 12 , , , cord-006824-btcdjmfp 122 13 bodyplethysmography bodyplethysmography NN cord-006824-btcdjmfp 122 14 ) ) -RRB- cord-006824-btcdjmfp 122 15 , , , cord-006824-btcdjmfp 122 16 capillary capillary JJ cord-006824-btcdjmfp 122 17 blood blood NN cord-006824-btcdjmfp 122 18 gas gas NN cord-006824-btcdjmfp 122 19 analysis analysis NN cord-006824-btcdjmfp 122 20 , , , cord-006824-btcdjmfp 122 21 non non JJ cord-006824-btcdjmfp 122 22 - - JJ cord-006824-btcdjmfp 122 23 invasive invasive JJ cord-006824-btcdjmfp 122 24 transcutaneous transcutaneous JJ cord-006824-btcdjmfp 122 25 assessment assessment NN cord-006824-btcdjmfp 122 26 of of IN cord-006824-btcdjmfp 122 27 oxygen oxygen NN cord-006824-btcdjmfp 122 28 saturation saturation NN cord-006824-btcdjmfp 122 29 , , , cord-006824-btcdjmfp 122 30 exercise exercise NN cord-006824-btcdjmfp 122 31 tests test NNS cord-006824-btcdjmfp 122 32 , , , cord-006824-btcdjmfp 122 33 bronchoalveolar bronchoalveolar NNP cord-006824-btcdjmfp 122 34 lavage lavage NNP cord-006824-btcdjmfp 122 35 ( ( -LRB- cord-006824-btcdjmfp 122 36 BAL BAL NNP cord-006824-btcdjmfp 122 37 ) ) -RRB- cord-006824-btcdjmfp 122 38 , , , cord-006824-btcdjmfp 122 39 transbronchial transbronchial NNP cord-006824-btcdjmfp 122 40 ( ( -LRB- cord-006824-btcdjmfp 122 41 TBB TBB NNP cord-006824-btcdjmfp 122 42 ) ) -RRB- cord-006824-btcdjmfp 122 43 or or CC cord-006824-btcdjmfp 122 44 open open JJ cord-006824-btcdjmfp 122 45 lung lung NN cord-006824-btcdjmfp 122 46 biopsy biopsy NN cord-006824-btcdjmfp 122 47 , , , cord-006824-btcdjmfp 122 48 ultrafast ultrafast JJ cord-006824-btcdjmfp 122 49 or or CC cord-006824-btcdjmfp 122 50 thin thin JJ cord-006824-btcdjmfp 122 51 section section NN cord-006824-btcdjmfp 122 52 computed compute VBN cord-006824-btcdjmfp 122 53 tomography tomography NN cord-006824-btcdjmfp 122 54 ( ( -LRB- cord-006824-btcdjmfp 122 55 CT CT NNP cord-006824-btcdjmfp 122 56 ) ) -RRB- cord-006824-btcdjmfp 122 57 ( ( -LRB- cord-006824-btcdjmfp 122 58 45 45 CD cord-006824-btcdjmfp 122 59 , , , cord-006824-btcdjmfp 122 60 49 49 CD cord-006824-btcdjmfp 122 61 , , , cord-006824-btcdjmfp 122 62 27 27 CD cord-006824-btcdjmfp 122 63 , , , cord-006824-btcdjmfp 122 64 21 21 CD cord-006824-btcdjmfp 122 65 , , , cord-006824-btcdjmfp 122 66 50 50 CD cord-006824-btcdjmfp 122 67 , , , cord-006824-btcdjmfp 122 68 19 19 CD cord-006824-btcdjmfp 122 69 , , , cord-006824-btcdjmfp 122 70 54 54 CD cord-006824-btcdjmfp 122 71 ) ) -RRB- cord-006824-btcdjmfp 122 72 . . . cord-006824-btcdjmfp 123 1 Material material NN cord-006824-btcdjmfp 123 2 obtained obtain VBN cord-006824-btcdjmfp 123 3 should should MD cord-006824-btcdjmfp 123 4 be be VB cord-006824-btcdjmfp 123 5 evaluated evaluate VBN cord-006824-btcdjmfp 123 6 by by IN cord-006824-btcdjmfp 123 7 the the DT cord-006824-btcdjmfp 123 8 most most RBS cord-006824-btcdjmfp 123 9 sensitive sensitive JJ cord-006824-btcdjmfp 123 10 and and CC cord-006824-btcdjmfp 123 11 specific specific JJ cord-006824-btcdjmfp 123 12 microbiological microbiological JJ cord-006824-btcdjmfp 123 13 and and CC cord-006824-btcdjmfp 123 14 pathological pathological JJ cord-006824-btcdjmfp 123 15 techniques technique NNS cord-006824-btcdjmfp 123 16 ( ( -LRB- cord-006824-btcdjmfp 123 17 7 7 CD cord-006824-btcdjmfp 123 18 ) ) -RRB- cord-006824-btcdjmfp 123 19 . . . cord-006824-btcdjmfp 124 1 In in IN cord-006824-btcdjmfp 124 2 the the DT cord-006824-btcdjmfp 124 3 early early JJ cord-006824-btcdjmfp 124 4 phase phase NN cord-006824-btcdjmfp 124 5 , , , cord-006824-btcdjmfp 124 6 infectious infectious JJ cord-006824-btcdjmfp 124 7 complications complication NNS cord-006824-btcdjmfp 124 8 are be VBP cord-006824-btcdjmfp 124 9 the the DT cord-006824-btcdjmfp 124 10 leading lead VBG cord-006824-btcdjmfp 124 11 differential differential JJ cord-006824-btcdjmfp 124 12 diagnoses diagnosis NNS cord-006824-btcdjmfp 124 13 , , , cord-006824-btcdjmfp 124 14 predominantly predominantly RB cord-006824-btcdjmfp 124 15 by by IN cord-006824-btcdjmfp 124 16 gram gram NN cord-006824-btcdjmfp 124 17 - - HYPH cord-006824-btcdjmfp 124 18 positive positive JJ cord-006824-btcdjmfp 124 19 and and CC cord-006824-btcdjmfp 124 20 gram gram JJ cord-006824-btcdjmfp 124 21 - - HYPH cord-006824-btcdjmfp 124 22 negative negative JJ cord-006824-btcdjmfp 124 23 bacteria bacteria NNS cord-006824-btcdjmfp 124 24 of of IN cord-006824-btcdjmfp 124 25 the the DT cord-006824-btcdjmfp 124 26 endogenous endogenous JJ cord-006824-btcdjmfp 124 27 flora flora NNS cord-006824-btcdjmfp 124 28 . . . cord-006824-btcdjmfp 125 1 In in IN cord-006824-btcdjmfp 125 2 prolonged prolonged JJ cord-006824-btcdjmfp 125 3 neutropenia neutropenia NN cord-006824-btcdjmfp 125 4 , , , cord-006824-btcdjmfp 125 5 invasive invasive JJ cord-006824-btcdjmfp 125 6 fungal fungal JJ cord-006824-btcdjmfp 125 7 infections infection NNS cord-006824-btcdjmfp 125 8 pose pose VBP cord-006824-btcdjmfp 125 9 considerable considerable JJ cord-006824-btcdjmfp 125 10 diagnostic diagnostic JJ cord-006824-btcdjmfp 125 11 and and CC cord-006824-btcdjmfp 125 12 therapeutic therapeutic JJ cord-006824-btcdjmfp 125 13 problems problem NNS cord-006824-btcdjmfp 125 14 . . . cord-006824-btcdjmfp 126 1 Secondly secondly RB cord-006824-btcdjmfp 126 2 , , , cord-006824-btcdjmfp 126 3 infections infection NNS cord-006824-btcdjmfp 126 4 by by IN cord-006824-btcdjmfp 126 5 cytomegaly cytomegaly NNP cord-006824-btcdjmfp 126 6 , , , cord-006824-btcdjmfp 126 7 EBV EBV NNP cord-006824-btcdjmfp 126 8 , , , cord-006824-btcdjmfp 126 9 adeno- adeno- NN cord-006824-btcdjmfp 126 10 , , , cord-006824-btcdjmfp 126 11 respiratory respiratory JJ cord-006824-btcdjmfp 126 12 - - HYPH cord-006824-btcdjmfp 126 13 syncytial syncytial JJ cord-006824-btcdjmfp 126 14 , , , cord-006824-btcdjmfp 126 15 parainfluenza parainfluenza NNP cord-006824-btcdjmfp 126 16 and and CC cord-006824-btcdjmfp 126 17 influenza influenza NN cord-006824-btcdjmfp 126 18 virus virus NN cord-006824-btcdjmfp 126 19 , , , cord-006824-btcdjmfp 126 20 HHV-6 HHV-6 NNP cord-006824-btcdjmfp 126 21 , , , cord-006824-btcdjmfp 126 22 as as RB cord-006824-btcdjmfp 126 23 well well RB cord-006824-btcdjmfp 126 24 as as IN cord-006824-btcdjmfp 126 25 by by IN cord-006824-btcdjmfp 126 26 chlamydia chlamydia NNP cord-006824-btcdjmfp 126 27 , , , cord-006824-btcdjmfp 126 28 mycoplasms mycoplasms NNP cord-006824-btcdjmfp 126 29 , , , cord-006824-btcdjmfp 126 30 legionella legionella NN cord-006824-btcdjmfp 126 31 , , , cord-006824-btcdjmfp 126 32 mycobacteria mycobacterium NNS cord-006824-btcdjmfp 126 33 , , , cord-006824-btcdjmfp 126 34 toxo toxo NN cord-006824-btcdjmfp 126 35 - - HYPH cord-006824-btcdjmfp 126 36 plasma plasma NN cord-006824-btcdjmfp 126 37 , , , cord-006824-btcdjmfp 126 38 and and CC cord-006824-btcdjmfp 126 39 pneumocystis pneumocystis NN cord-006824-btcdjmfp 126 40 - - HYPH cord-006824-btcdjmfp 126 41 carinii carinii FW cord-006824-btcdjmfp 126 42 should should MD cord-006824-btcdjmfp 126 43 be be VB cord-006824-btcdjmfp 126 44 considered consider VBN cord-006824-btcdjmfp 126 45 . . . cord-006824-btcdjmfp 127 1 Infections infection NNS cord-006824-btcdjmfp 127 2 by by IN cord-006824-btcdjmfp 127 3 herpes herpe NNS cord-006824-btcdjmfp 127 4 virus virus NN cord-006824-btcdjmfp 127 5 have have VBP cord-006824-btcdjmfp 127 6 reached reach VBN cord-006824-btcdjmfp 127 7 their -PRON- PRP$ cord-006824-btcdjmfp 127 8 nadir nadir NN cord-006824-btcdjmfp 128 1 90 90 CD cord-006824-btcdjmfp 128 2 days day NNS cord-006824-btcdjmfp 128 3 post post NN cord-006824-btcdjmfp 128 4 HSCT HSCT NNP cord-006824-btcdjmfp 128 5 . . . cord-006824-btcdjmfp 129 1 However however RB cord-006824-btcdjmfp 129 2 , , , cord-006824-btcdjmfp 129 3 all all DT cord-006824-btcdjmfp 129 4 viral viral JJ cord-006824-btcdjmfp 129 5 , , , cord-006824-btcdjmfp 129 6 bacterial bacterial JJ cord-006824-btcdjmfp 129 7 and and CC cord-006824-btcdjmfp 129 8 fungal fungal JJ cord-006824-btcdjmfp 129 9 infections infection NNS cord-006824-btcdjmfp 129 10 can can MD cord-006824-btcdjmfp 129 11 also also RB cord-006824-btcdjmfp 129 12 occur occur VB cord-006824-btcdjmfp 129 13 at at IN cord-006824-btcdjmfp 129 14 a a DT cord-006824-btcdjmfp 129 15 later later JJ cord-006824-btcdjmfp 129 16 time time NN cord-006824-btcdjmfp 129 17 point point NN cord-006824-btcdjmfp 129 18 depending depend VBG cord-006824-btcdjmfp 129 19 on on IN cord-006824-btcdjmfp 129 20 the the DT cord-006824-btcdjmfp 129 21 state state NN cord-006824-btcdjmfp 129 22 of of IN cord-006824-btcdjmfp 129 23 immunity immunity NN cord-006824-btcdjmfp 129 24 , , , cord-006824-btcdjmfp 129 25 donor donor NN cord-006824-btcdjmfp 129 26 selection selection NN cord-006824-btcdjmfp 129 27 , , , cord-006824-btcdjmfp 129 28 and and CC cord-006824-btcdjmfp 129 29 preparation preparation NN cord-006824-btcdjmfp 129 30 of of IN cord-006824-btcdjmfp 129 31 the the DT cord-006824-btcdjmfp 129 32 transplant transplant NN cord-006824-btcdjmfp 129 33 . . . cord-006824-btcdjmfp 130 1 Furthermore furthermore RB cord-006824-btcdjmfp 130 2 , , , cord-006824-btcdjmfp 130 3 GVHD GVHD NNP cord-006824-btcdjmfp 130 4 and and CC cord-006824-btcdjmfp 130 5 its -PRON- PRP$ cord-006824-btcdjmfp 130 6 therapy therapy NN cord-006824-btcdjmfp 130 7 play play VBP cord-006824-btcdjmfp 130 8 a a DT cord-006824-btcdjmfp 130 9 pathogenetic pathogenetic JJ cord-006824-btcdjmfp 130 10 role role NN cord-006824-btcdjmfp 130 11 in in IN cord-006824-btcdjmfp 130 12 the the DT cord-006824-btcdjmfp 130 13 development development NN cord-006824-btcdjmfp 130 14 of of IN cord-006824-btcdjmfp 130 15 so so RB cord-006824-btcdjmfp 130 16 - - HYPH cord-006824-btcdjmfp 130 17 called call VBN cord-006824-btcdjmfp 130 18 noninfectious noninfectious JJ cord-006824-btcdjmfp 130 19 pulmonary pulmonary JJ cord-006824-btcdjmfp 130 20 complications complication NNS cord-006824-btcdjmfp 130 21 . . . cord-006824-btcdjmfp 131 1 The the DT cord-006824-btcdjmfp 131 2 treatment treatment NN cord-006824-btcdjmfp 131 3 or or CC cord-006824-btcdjmfp 131 4 prophylaxis prophylaxis NN cord-006824-btcdjmfp 131 5 of of IN cord-006824-btcdjmfp 131 6 infectious infectious JJ cord-006824-btcdjmfp 131 7 diseases disease NNS cord-006824-btcdjmfp 131 8 may may MD cord-006824-btcdjmfp 131 9 have have VB cord-006824-btcdjmfp 131 10 equally equally RB cord-006824-btcdjmfp 131 11 profound profound JJ cord-006824-btcdjmfp 131 12 impact impact NN cord-006824-btcdjmfp 131 13 on on IN cord-006824-btcdjmfp 131 14 the the DT cord-006824-btcdjmfp 131 15 pattern pattern NN cord-006824-btcdjmfp 131 16 of of IN cord-006824-btcdjmfp 131 17 non non JJ cord-006824-btcdjmfp 131 18 - - JJ cord-006824-btcdjmfp 131 19 infectious infectious JJ cord-006824-btcdjmfp 131 20 lung lung NN cord-006824-btcdjmfp 131 21 diseases disease NNS cord-006824-btcdjmfp 131 22 observed observe VBD cord-006824-btcdjmfp 131 23 ( ( -LRB- cord-006824-btcdjmfp 131 24 4 4 CD cord-006824-btcdjmfp 131 25 ) ) -RRB- cord-006824-btcdjmfp 131 26 . . . cord-006824-btcdjmfp 132 1 Among among IN cord-006824-btcdjmfp 132 2 non non JJ cord-006824-btcdjmfp 132 3 - - JJ cord-006824-btcdjmfp 132 4 infectious infectious JJ cord-006824-btcdjmfp 132 5 pulmonary pulmonary JJ cord-006824-btcdjmfp 132 6 complications complication NNS cord-006824-btcdjmfp 132 7 in in IN cord-006824-btcdjmfp 132 8 the the DT cord-006824-btcdjmfp 132 9 early early JJ cord-006824-btcdjmfp 132 10 phase phase NN cord-006824-btcdjmfp 132 11 , , , cord-006824-btcdjmfp 132 12 a a DT cord-006824-btcdjmfp 132 13 group group NN cord-006824-btcdjmfp 132 14 of of IN cord-006824-btcdjmfp 132 15 diffuse diffuse JJ cord-006824-btcdjmfp 132 16 interstitial interstitial JJ cord-006824-btcdjmfp 132 17 pneumonias pneumonia NNS cord-006824-btcdjmfp 132 18 is be VBZ cord-006824-btcdjmfp 132 19 responsible responsible JJ cord-006824-btcdjmfp 132 20 for for IN cord-006824-btcdjmfp 132 21 high high JJ cord-006824-btcdjmfp 132 22 mortality mortality NN cord-006824-btcdjmfp 132 23 . . . cord-006824-btcdjmfp 133 1 Some some DT cord-006824-btcdjmfp 133 2 of of IN cord-006824-btcdjmfp 133 3 these these DT cord-006824-btcdjmfp 133 4 alterations alteration NNS cord-006824-btcdjmfp 133 5 were be VBD cord-006824-btcdjmfp 133 6 defined define VBN cord-006824-btcdjmfp 133 7 at at IN cord-006824-btcdjmfp 133 8 the the DT cord-006824-btcdjmfp 133 9 1991 1991 CD cord-006824-btcdjmfp 133 10 NIHLBI NIHLBI NNP cord-006824-btcdjmfp 133 11 Workshop Workshop NNP cord-006824-btcdjmfp 133 12 in in IN cord-006824-btcdjmfp 133 13 Bethesda Bethesda NNP cord-006824-btcdjmfp 133 14 as as IN cord-006824-btcdjmfp 133 15 " " `` cord-006824-btcdjmfp 133 16 idiopathic idiopathic JJ cord-006824-btcdjmfp 133 17 pneumonia pneumonia NN cord-006824-btcdjmfp 133 18 syndrome syndrome NN cord-006824-btcdjmfp 133 19 " " '' cord-006824-btcdjmfp 133 20 ( ( -LRB- cord-006824-btcdjmfp 133 21 IPS IPS NNP cord-006824-btcdjmfp 133 22 ) ) -RRB- cord-006824-btcdjmfp 133 23 [ [ -LRB- cord-006824-btcdjmfp 133 24 15 15 CD cord-006824-btcdjmfp 133 25 ] ] -RRB- cord-006824-btcdjmfp 133 26 . . . cord-006824-btcdjmfp 134 1 Immediately immediately RB cord-006824-btcdjmfp 134 2 after after IN cord-006824-btcdjmfp 134 3 transplantation transplantation NN cord-006824-btcdjmfp 134 4 the the DT cord-006824-btcdjmfp 134 5 so so RB cord-006824-btcdjmfp 134 6 - - HYPH cord-006824-btcdjmfp 134 7 called call VBN cord-006824-btcdjmfp 134 8 " " `` cord-006824-btcdjmfp 134 9 engraftment engraftment NNP cord-006824-btcdjmfp 134 10 syndrome syndrome NN cord-006824-btcdjmfp 134 11 " " '' cord-006824-btcdjmfp 134 12 or or CC cord-006824-btcdjmfp 134 13 " " `` cord-006824-btcdjmfp 134 14 capillary capillary JJ cord-006824-btcdjmfp 134 15 - - HYPH cord-006824-btcdjmfp 134 16 leak leak NN cord-006824-btcdjmfp 134 17 syndrome syndrome NN cord-006824-btcdjmfp 134 18 " " '' cord-006824-btcdjmfp 134 19 play play VB cord-006824-btcdjmfp 134 20 an an DT cord-006824-btcdjmfp 134 21 important important JJ cord-006824-btcdjmfp 134 22 role role NN cord-006824-btcdjmfp 134 23 ( ( -LRB- cord-006824-btcdjmfp 134 24 47 47 CD cord-006824-btcdjmfp 134 25 ) ) -RRB- cord-006824-btcdjmfp 134 26 , , , cord-006824-btcdjmfp 134 27 which which WDT cord-006824-btcdjmfp 134 28 has have VBZ cord-006824-btcdjmfp 134 29 to to TO cord-006824-btcdjmfp 134 30 be be VB cord-006824-btcdjmfp 134 31 distiguished distiguishe VBN cord-006824-btcdjmfp 134 32 from from IN cord-006824-btcdjmfp 134 33 diffuse diffuse JJ cord-006824-btcdjmfp 134 34 alveolar alveolar JJ cord-006824-btcdjmfp 134 35 damage damage NN cord-006824-btcdjmfp 134 36 ( ( -LRB- cord-006824-btcdjmfp 134 37 DAD DAD NNP cord-006824-btcdjmfp 134 38 ) ) -RRB- cord-006824-btcdjmfp 134 39 or or CC cord-006824-btcdjmfp 134 40 the the DT cord-006824-btcdjmfp 134 41 idiopathic idiopathic JJ cord-006824-btcdjmfp 134 42 pneumonia pneumonia NN cord-006824-btcdjmfp 134 43 syndrome syndrome NN cord-006824-btcdjmfp 134 44 . . . cord-006824-btcdjmfp 135 1 The the DT cord-006824-btcdjmfp 135 2 latter latter JJ cord-006824-btcdjmfp 135 3 ones one NNS cord-006824-btcdjmfp 135 4 are be VBP cord-006824-btcdjmfp 135 5 considered consider VBN cord-006824-btcdjmfp 135 6 primarily primarily RB cord-006824-btcdjmfp 135 7 as as IN cord-006824-btcdjmfp 135 8 forms form NNS cord-006824-btcdjmfp 135 9 of of IN cord-006824-btcdjmfp 135 10 ARDS ARDS NNP cord-006824-btcdjmfp 135 11 because because IN cord-006824-btcdjmfp 135 12 their -PRON- PRP$ cord-006824-btcdjmfp 135 13 time time NN cord-006824-btcdjmfp 135 14 course course NN cord-006824-btcdjmfp 135 15 , , , cord-006824-btcdjmfp 135 16 their -PRON- PRP$ cord-006824-btcdjmfp 135 17 histopathologic histopathologic JJ cord-006824-btcdjmfp 135 18 morphological morphological JJ cord-006824-btcdjmfp 135 19 criteria criterion NNS cord-006824-btcdjmfp 135 20 and and CC cord-006824-btcdjmfp 135 21 their -PRON- PRP$ cord-006824-btcdjmfp 135 22 clinical clinical JJ cord-006824-btcdjmfp 135 23 appearance appearance NN cord-006824-btcdjmfp 135 24 closely closely RB cord-006824-btcdjmfp 135 25 resemble resemble VB cord-006824-btcdjmfp 135 26 this this DT cord-006824-btcdjmfp 135 27 complicationwhich complicationwhich NN cord-006824-btcdjmfp 135 28 , , , cord-006824-btcdjmfp 135 29 despite despite IN cord-006824-btcdjmfp 135 30 various various JJ cord-006824-btcdjmfp 135 31 causes cause NNS cord-006824-btcdjmfp 135 32 , , , cord-006824-btcdjmfp 135 33 generally generally RB cord-006824-btcdjmfp 135 34 has have VBZ cord-006824-btcdjmfp 135 35 an an DT cord-006824-btcdjmfp 135 36 unfavourable unfavourable JJ cord-006824-btcdjmfp 135 37 prognosis prognosis NN cord-006824-btcdjmfp 135 38 [ [ -LRB- cord-006824-btcdjmfp 135 39 12 12 CD cord-006824-btcdjmfp 135 40 , , , cord-006824-btcdjmfp 135 41 13 13 CD cord-006824-btcdjmfp 135 42 ] ] -RRB- cord-006824-btcdjmfp 135 43 . . . cord-006824-btcdjmfp 136 1 The the DT cord-006824-btcdjmfp 136 2 incidence incidence NN cord-006824-btcdjmfp 136 3 of of IN cord-006824-btcdjmfp 136 4 IPS IPS NNP cord-006824-btcdjmfp 136 5 after after IN cord-006824-btcdjmfp 136 6 allogeneic allogeneic NN cord-006824-btcdjmfp 136 7 HSCT HSCT NNP cord-006824-btcdjmfp 136 8 has have VBZ cord-006824-btcdjmfp 136 9 been be VBN cord-006824-btcdjmfp 136 10 reported report VBN cord-006824-btcdjmfp 136 11 as as IN cord-006824-btcdjmfp 136 12 12 12 CD cord-006824-btcdjmfp 136 13 % % NN cord-006824-btcdjmfp 136 14 [ [ -LRB- cord-006824-btcdjmfp 136 15 15 15 CD cord-006824-btcdjmfp 136 16 ] ] -RRB- cord-006824-btcdjmfp 136 17 or or CC cord-006824-btcdjmfp 136 18 8 8 CD cord-006824-btcdjmfp 136 19 % % NN cord-006824-btcdjmfp 136 20 [ [ -LRB- cord-006824-btcdjmfp 136 21 41 41 CD cord-006824-btcdjmfp 136 22 ] ] -RRB- cord-006824-btcdjmfp 136 23 for for IN cord-006824-btcdjmfp 136 24 all all DT cord-006824-btcdjmfp 136 25 ages age NNS cord-006824-btcdjmfp 136 26 , , , cord-006824-btcdjmfp 136 27 and and CC cord-006824-btcdjmfp 136 28 is be VBZ cord-006824-btcdjmfp 136 29 certainly certainly RB cord-006824-btcdjmfp 136 30 lower low JJR cord-006824-btcdjmfp 136 31 for for IN cord-006824-btcdjmfp 136 32 all all DT cord-006824-btcdjmfp 136 33 donors donor NNS cord-006824-btcdjmfp 136 34 among among IN cord-006824-btcdjmfp 136 35 children child NNS cord-006824-btcdjmfp 136 36 . . . cord-006824-btcdjmfp 137 1 The the DT cord-006824-btcdjmfp 137 2 mortality mortality NN cord-006824-btcdjmfp 137 3 of of IN cord-006824-btcdjmfp 137 4 this this DT cord-006824-btcdjmfp 137 5 complication complication NN cord-006824-btcdjmfp 137 6 is be VBZ cord-006824-btcdjmfp 137 7 high high JJ cord-006824-btcdjmfp 137 8 , , , cord-006824-btcdjmfp 137 9 despite despite IN cord-006824-btcdjmfp 137 10 intensive intensive JJ cord-006824-btcdjmfp 137 11 care care NN cord-006824-btcdjmfp 137 12 treatment treatment NN cord-006824-btcdjmfp 137 13 including include VBG cord-006824-btcdjmfp 137 14 mechanical mechanical JJ cord-006824-btcdjmfp 137 15 ventilation ventilation NN cord-006824-btcdjmfp 137 16 ( ( -LRB- cord-006824-btcdjmfp 137 17 36 36 CD cord-006824-btcdjmfp 137 18 ) ) -RRB- cord-006824-btcdjmfp 137 19 . . . cord-006824-btcdjmfp 138 1 According accord VBG cord-006824-btcdjmfp 138 2 to to IN cord-006824-btcdjmfp 138 3 a a DT cord-006824-btcdjmfp 138 4 retrospective retrospective JJ cord-006824-btcdjmfp 138 5 analysis analysis NN cord-006824-btcdjmfp 138 6 of of IN cord-006824-btcdjmfp 138 7 1165 1165 CD cord-006824-btcdjmfp 138 8 HSCT HSCT NNP cord-006824-btcdjmfp 138 9 patients patient NNS cord-006824-btcdjmfp 138 10 , , , cord-006824-btcdjmfp 138 11 mortality mortality NN cord-006824-btcdjmfp 138 12 is be VBZ cord-006824-btcdjmfp 138 13 estimated estimate VBN cord-006824-btcdjmfp 138 14 to to TO cord-006824-btcdjmfp 138 15 be be VB cord-006824-btcdjmfp 138 16 around around IN cord-006824-btcdjmfp 138 17 70 70 CD cord-006824-btcdjmfp 138 18 % % NN cord-006824-btcdjmfp 138 19 [ [ -LRB- cord-006824-btcdjmfp 138 20 41 41 CD cord-006824-btcdjmfp 138 21 ] ] -RRB- cord-006824-btcdjmfp 138 22 . . . cord-006824-btcdjmfp 139 1 Essential essential JJ cord-006824-btcdjmfp 139 2 diagnostic diagnostic JJ cord-006824-btcdjmfp 139 3 criteria criterion NNS cord-006824-btcdjmfp 139 4 are be VBP cord-006824-btcdjmfp 139 5 ( ( -LRB- cord-006824-btcdjmfp 139 6 1 1 CD cord-006824-btcdjmfp 139 7 ) ) -RRB- cord-006824-btcdjmfp 139 8 indicators indicator NNS cord-006824-btcdjmfp 139 9 of of IN cord-006824-btcdjmfp 139 10 diffuse diffuse JJ cord-006824-btcdjmfp 139 11 alveolar alveolar NN cord-006824-btcdjmfp 139 12 damage damage NN cord-006824-btcdjmfp 139 13 ( ( -LRB- cord-006824-btcdjmfp 139 14 multilobular multilobular NNP cord-006824-btcdjmfp 139 15 infiltrates infiltrate VBZ cord-006824-btcdjmfp 139 16 in in IN cord-006824-btcdjmfp 139 17 thorax thorax NN cord-006824-btcdjmfp 139 18 X x NN cord-006824-btcdjmfp 139 19 - - NN cord-006824-btcdjmfp 139 20 ray ray NN cord-006824-btcdjmfp 139 21 or or CC cord-006824-btcdjmfp 139 22 disturbance disturbance NN cord-006824-btcdjmfp 139 23 of of IN cord-006824-btcdjmfp 139 24 gas gas NN cord-006824-btcdjmfp 139 25 transfer transfer NN cord-006824-btcdjmfp 139 26 , , , cord-006824-btcdjmfp 139 27 a a DT cord-006824-btcdjmfp 139 28 restrictive restrictive JJ cord-006824-btcdjmfp 139 29 ventilatory ventilatory JJ cord-006824-btcdjmfp 139 30 defect defect NN cord-006824-btcdjmfp 139 31 , , , cord-006824-btcdjmfp 139 32 clinical clinical JJ cord-006824-btcdjmfp 139 33 signs sign NNS cord-006824-btcdjmfp 139 34 of of IN cord-006824-btcdjmfp 139 35 pneumonia pneumonia NN cord-006824-btcdjmfp 139 36 ) ) -RRB- cord-006824-btcdjmfp 139 37 and and CC cord-006824-btcdjmfp 139 38 ( ( -LRB- cord-006824-btcdjmfp 139 39 2 2 LS cord-006824-btcdjmfp 139 40 ) ) -RRB- cord-006824-btcdjmfp 139 41 the the DT cord-006824-btcdjmfp 139 42 exclusion exclusion NN cord-006824-btcdjmfp 139 43 of of IN cord-006824-btcdjmfp 139 44 active active JJ cord-006824-btcdjmfp 139 45 infection infection NN cord-006824-btcdjmfp 139 46 of of IN cord-006824-btcdjmfp 139 47 lower low JJR cord-006824-btcdjmfp 139 48 airways airway NNS cord-006824-btcdjmfp 139 49 by by IN cord-006824-btcdjmfp 139 50 bronchoalveolar bronchoalveolar NNP cord-006824-btcdjmfp 139 51 lavage lavage NNP cord-006824-btcdjmfp 139 52 ( ( -LRB- cord-006824-btcdjmfp 139 53 BAL BAL NNP cord-006824-btcdjmfp 139 54 ) ) -RRB- cord-006824-btcdjmfp 139 55 or or CC cord-006824-btcdjmfp 139 56 transbronchial transbronchial JJ cord-006824-btcdjmfp 139 57 biopsy biopsy NN cord-006824-btcdjmfp 139 58 ( ( -LRB- cord-006824-btcdjmfp 139 59 TBB TBB NNP cord-006824-btcdjmfp 139 60 ) ) -RRB- cord-006824-btcdjmfp 139 61 . . . cord-006824-btcdjmfp 140 1 Patients patient NNS cord-006824-btcdjmfp 140 2 with with IN cord-006824-btcdjmfp 140 3 severe severe JJ cord-006824-btcdjmfp 140 4 acute acute JJ cord-006824-btcdjmfp 140 5 graft graft NN cord-006824-btcdjmfp 140 6 versus versus IN cord-006824-btcdjmfp 140 7 host host NN cord-006824-btcdjmfp 140 8 disease disease NN cord-006824-btcdjmfp 140 9 ( ( -LRB- cord-006824-btcdjmfp 140 10 GVHD GVHD NNP cord-006824-btcdjmfp 140 11 grade grade NN cord-006824-btcdjmfp 140 12 III III NNP cord-006824-btcdjmfp 140 13 - - HYPH cord-006824-btcdjmfp 140 14 IV IV NNP cord-006824-btcdjmfp 140 15 ) ) -RRB- cord-006824-btcdjmfp 140 16 have have VBP cord-006824-btcdjmfp 140 17 a a DT cord-006824-btcdjmfp 140 18 largely largely RB cord-006824-btcdjmfp 140 19 increased increase VBN cord-006824-btcdjmfp 140 20 risk risk NN cord-006824-btcdjmfp 140 21 of of IN cord-006824-btcdjmfp 140 22 developing develop VBG cord-006824-btcdjmfp 140 23 IPS IPS NNP cord-006824-btcdjmfp 140 24 . . . cord-006824-btcdjmfp 141 1 It -PRON- PRP cord-006824-btcdjmfp 141 2 has have VBZ cord-006824-btcdjmfp 141 3 not not RB cord-006824-btcdjmfp 141 4 been be VBN cord-006824-btcdjmfp 141 5 clear clear JJ cord-006824-btcdjmfp 141 6 whether whether IN cord-006824-btcdjmfp 141 7 IPS IPS NNP cord-006824-btcdjmfp 141 8 after after IN cord-006824-btcdjmfp 141 9 transplantation transplantation NN cord-006824-btcdjmfp 141 10 represents represent VBZ cord-006824-btcdjmfp 141 11 T t NN cord-006824-btcdjmfp 141 12 - - HYPH cord-006824-btcdjmfp 141 13 cell cell NN cord-006824-btcdjmfp 141 14 - - HYPH cord-006824-btcdjmfp 141 15 mediated mediate VBN cord-006824-btcdjmfp 141 16 lung lung NN cord-006824-btcdjmfp 141 17 damage damage NN cord-006824-btcdjmfp 142 1 ( ( -LRB- cord-006824-btcdjmfp 142 2 e.g. e.g. RB cord-006824-btcdjmfp 142 3 " " `` cord-006824-btcdjmfp 142 4 acute acute JJ cord-006824-btcdjmfp 142 5 GVHD GVHD NNP cord-006824-btcdjmfp 142 6 of of IN cord-006824-btcdjmfp 142 7 the the DT cord-006824-btcdjmfp 142 8 lung lung NN cord-006824-btcdjmfp 142 9 " " '' cord-006824-btcdjmfp 142 10 ) ) -RRB- cord-006824-btcdjmfp 142 11 or or CC cord-006824-btcdjmfp 142 12 is be VBZ cord-006824-btcdjmfp 142 13 triggered trigger VBN cord-006824-btcdjmfp 142 14 by by IN cord-006824-btcdjmfp 142 15 occult occult JJ cord-006824-btcdjmfp 142 16 viral viral JJ cord-006824-btcdjmfp 142 17 infections infection NNS cord-006824-btcdjmfp 142 18 ( ( -LRB- cord-006824-btcdjmfp 142 19 e.g. e.g. RB cord-006824-btcdjmfp 142 20 adeno adeno NNP cord-006824-btcdjmfp 142 21 or or CC cord-006824-btcdjmfp 142 22 HHV-6 HHV-6 NNP cord-006824-btcdjmfp 142 23 ) ) -RRB- cord-006824-btcdjmfp 142 24 , , , cord-006824-btcdjmfp 142 25 or or CC cord-006824-btcdjmfp 142 26 can can MD cord-006824-btcdjmfp 142 27 be be VB cord-006824-btcdjmfp 142 28 considered consider VBN cord-006824-btcdjmfp 142 29 as as IN cord-006824-btcdjmfp 142 30 a a DT cord-006824-btcdjmfp 142 31 consequence consequence NN cord-006824-btcdjmfp 142 32 of of IN cord-006824-btcdjmfp 142 33 a a DT cord-006824-btcdjmfp 142 34 multiple multiple JJ cord-006824-btcdjmfp 142 35 organ organ NN cord-006824-btcdjmfp 142 36 failure failure NN cord-006824-btcdjmfp 142 37 during during IN cord-006824-btcdjmfp 142 38 generalised generalised JJ cord-006824-btcdjmfp 142 39 activation activation NN cord-006824-btcdjmfp 142 40 of of IN cord-006824-btcdjmfp 142 41 inflammatory inflammatory JJ cord-006824-btcdjmfp 142 42 mediators mediator NNS cord-006824-btcdjmfp 142 43 ( ( -LRB- cord-006824-btcdjmfp 142 44 analogous analogous JJ cord-006824-btcdjmfp 142 45 to to IN cord-006824-btcdjmfp 142 46 the the DT cord-006824-btcdjmfp 142 47 multifactorial multifactorial JJ cord-006824-btcdjmfp 142 48 ARDS ARDS NNP cord-006824-btcdjmfp 142 49 of of IN cord-006824-btcdjmfp 142 50 non non JJ cord-006824-btcdjmfp 142 51 - - JJ cord-006824-btcdjmfp 142 52 transplanted transplanted JJ cord-006824-btcdjmfp 142 53 patients patient NNS cord-006824-btcdjmfp 142 54 ) ) -RRB- cord-006824-btcdjmfp 142 55 in in IN cord-006824-btcdjmfp 142 56 acute acute JJ cord-006824-btcdjmfp 142 57 GVHD GVHD NNP cord-006824-btcdjmfp 142 58 , , , cord-006824-btcdjmfp 142 59 in in IN cord-006824-btcdjmfp 142 60 the the DT cord-006824-btcdjmfp 142 61 course course NN cord-006824-btcdjmfp 142 62 of of IN cord-006824-btcdjmfp 142 63 viral viral JJ cord-006824-btcdjmfp 142 64 infections infection NNS cord-006824-btcdjmfp 142 65 or or CC cord-006824-btcdjmfp 142 66 sepsis sepsis NN cord-006824-btcdjmfp 142 67 . . . cord-006824-btcdjmfp 143 1 There there EX cord-006824-btcdjmfp 143 2 is be VBZ cord-006824-btcdjmfp 143 3 no no DT cord-006824-btcdjmfp 143 4 specific specific JJ cord-006824-btcdjmfp 143 5 therapy therapy NN cord-006824-btcdjmfp 143 6 for for IN cord-006824-btcdjmfp 143 7 the the DT cord-006824-btcdjmfp 143 8 IPS IPS NNP cord-006824-btcdjmfp 143 9 to to IN cord-006824-btcdjmfp 143 10 date date NN cord-006824-btcdjmfp 143 11 . . . cord-006824-btcdjmfp 144 1 Therefore therefore RB cord-006824-btcdjmfp 144 2 diffuse diffuse VB cord-006824-btcdjmfp 144 3 infiltrates infiltrate NNS cord-006824-btcdjmfp 144 4 on on IN cord-006824-btcdjmfp 144 5 X x NN cord-006824-btcdjmfp 144 6 - - NN cord-006824-btcdjmfp 144 7 ray ray NN cord-006824-btcdjmfp 144 8 after after IN cord-006824-btcdjmfp 144 9 transplantation transplantation NN cord-006824-btcdjmfp 144 10 have have VBP cord-006824-btcdjmfp 144 11 to to TO cord-006824-btcdjmfp 144 12 be be VB cord-006824-btcdjmfp 144 13 subject subject JJ cord-006824-btcdjmfp 144 14 to to IN cord-006824-btcdjmfp 144 15 a a DT cord-006824-btcdjmfp 144 16 thorough thorough JJ cord-006824-btcdjmfp 144 17 work work NN cord-006824-btcdjmfp 144 18 - - HYPH cord-006824-btcdjmfp 144 19 up up NN cord-006824-btcdjmfp 144 20 . . . cord-006824-btcdjmfp 145 1 If if IN cord-006824-btcdjmfp 145 2 they -PRON- PRP cord-006824-btcdjmfp 145 3 do do VBP cord-006824-btcdjmfp 145 4 not not RB cord-006824-btcdjmfp 145 5 respond respond VB cord-006824-btcdjmfp 145 6 to to IN cord-006824-btcdjmfp 145 7 diuretics diuretic NNS cord-006824-btcdjmfp 145 8 ( ( -LRB- cord-006824-btcdjmfp 145 9 to to TO cord-006824-btcdjmfp 145 10 exclude exclude VB cord-006824-btcdjmfp 145 11 pulmonary pulmonary JJ cord-006824-btcdjmfp 145 12 edema edema NN cord-006824-btcdjmfp 145 13 ) ) -RRB- cord-006824-btcdjmfp 145 14 , , , cord-006824-btcdjmfp 145 15 they -PRON- PRP cord-006824-btcdjmfp 145 16 have have VBP cord-006824-btcdjmfp 145 17 to to TO cord-006824-btcdjmfp 145 18 be be VB cord-006824-btcdjmfp 145 19 evaluated evaluate VBN cord-006824-btcdjmfp 145 20 radialogically radialogically RB cord-006824-btcdjmfp 145 21 , , , cord-006824-btcdjmfp 145 22 treated treat VBN cord-006824-btcdjmfp 145 23 empirically empirically RB cord-006824-btcdjmfp 145 24 for for IN cord-006824-btcdjmfp 145 25 a a DT cord-006824-btcdjmfp 145 26 short short JJ cord-006824-btcdjmfp 145 27 time time NN cord-006824-btcdjmfp 145 28 and/or and/or CC cord-006824-btcdjmfp 145 29 evaluated evaluate VBN cord-006824-btcdjmfp 145 30 invasively invasively RB cord-006824-btcdjmfp 145 31 depending depend VBG cord-006824-btcdjmfp 145 32 upon upon IN cord-006824-btcdjmfp 145 33 the the DT cord-006824-btcdjmfp 145 34 radiological radiological JJ cord-006824-btcdjmfp 145 35 appearance appearance NN cord-006824-btcdjmfp 145 36 before before IN cord-006824-btcdjmfp 145 37 or or CC cord-006824-btcdjmfp 145 38 shortly shortly RB cord-006824-btcdjmfp 145 39 after after IN cord-006824-btcdjmfp 145 40 the the DT cord-006824-btcdjmfp 145 41 start start NN cord-006824-btcdjmfp 145 42 of of IN cord-006824-btcdjmfp 145 43 antibiotics antibiotic NNS cord-006824-btcdjmfp 145 44 . . . cord-006824-btcdjmfp 146 1 Diagnostic diagnostic JJ cord-006824-btcdjmfp 146 2 criteria criterion NNS cord-006824-btcdjmfp 146 3 for for IN cord-006824-btcdjmfp 146 4 " " `` cord-006824-btcdjmfp 146 5 capillary capillary JJ cord-006824-btcdjmfp 146 6 leak leak NN cord-006824-btcdjmfp 146 7 syndrome syndrome NN cord-006824-btcdjmfp 146 8 " " '' cord-006824-btcdjmfp 146 9 , , , cord-006824-btcdjmfp 146 10 which which WDT cord-006824-btcdjmfp 146 11 also also RB cord-006824-btcdjmfp 146 12 occurs occur VBZ cord-006824-btcdjmfp 146 13 in in IN cord-006824-btcdjmfp 146 14 the the DT cord-006824-btcdjmfp 146 15 early early JJ cord-006824-btcdjmfp 146 16 phase phase NN cord-006824-btcdjmfp 146 17 after after IN cord-006824-btcdjmfp 146 18 transplantation transplantation NN cord-006824-btcdjmfp 146 19 , , , cord-006824-btcdjmfp 146 20 are be VBP cord-006824-btcdjmfp 146 21 inadequate inadequate JJ cord-006824-btcdjmfp 146 22 weight weight NN cord-006824-btcdjmfp 146 23 gain gain NN cord-006824-btcdjmfp 146 24 and and CC cord-006824-btcdjmfp 146 25 disturbance disturbance NN cord-006824-btcdjmfp 146 26 of of IN cord-006824-btcdjmfp 146 27 gas gas NN cord-006824-btcdjmfp 146 28 transfer transfer NN cord-006824-btcdjmfp 146 29 . . . cord-006824-btcdjmfp 147 1 Therapy therapy NN cord-006824-btcdjmfp 147 2 with with IN cord-006824-btcdjmfp 147 3 C1-esterase c1-esterase NN cord-006824-btcdjmfp 147 4 inhibitor inhibitor NN cord-006824-btcdjmfp 147 5 is be VBZ cord-006824-btcdjmfp 147 6 currently currently RB cord-006824-btcdjmfp 147 7 under under IN cord-006824-btcdjmfp 147 8 evaluation evaluation NN cord-006824-btcdjmfp 147 9 ( ( -LRB- cord-006824-btcdjmfp 147 10 56 56 CD cord-006824-btcdjmfp 147 11 ) ) -RRB- cord-006824-btcdjmfp 147 12 . . . cord-006824-btcdjmfp 148 1 Diffuse diffuse JJ cord-006824-btcdjmfp 148 2 alveolar alveolar NN cord-006824-btcdjmfp 148 3 hemorrhage hemorrhage NN cord-006824-btcdjmfp 148 4 syndrome syndrome NN cord-006824-btcdjmfp 149 1 ( ( -LRB- cord-006824-btcdjmfp 149 2 DAH DAH NNP cord-006824-btcdjmfp 149 3 ) ) -RRB- cord-006824-btcdjmfp 149 4 is be VBZ cord-006824-btcdjmfp 149 5 another another DT cord-006824-btcdjmfp 149 6 early early JJ cord-006824-btcdjmfp 149 7 " " `` cord-006824-btcdjmfp 149 8 non non JJ cord-006824-btcdjmfp 149 9 - - JJ cord-006824-btcdjmfp 149 10 infectious infectious JJ cord-006824-btcdjmfp 149 11 " " `` cord-006824-btcdjmfp 149 12 pulmonary pulmonary JJ cord-006824-btcdjmfp 149 13 complication complication NN cord-006824-btcdjmfp 149 14 ( ( -LRB- cord-006824-btcdjmfp 149 15 day day NN cord-006824-btcdjmfp 149 16 +7 +7 CD cord-006824-btcdjmfp 149 17 until until IN cord-006824-btcdjmfp 149 18 +40 +40 CD cord-006824-btcdjmfp 149 19 ) ) -RRB- cord-006824-btcdjmfp 149 20 . . . cord-006824-btcdjmfp 150 1 Its -PRON- PRP$ cord-006824-btcdjmfp 150 2 occurrence occurrence NN cord-006824-btcdjmfp 150 3 has have VBZ cord-006824-btcdjmfp 150 4 been be VBN cord-006824-btcdjmfp 150 5 described describe VBN cord-006824-btcdjmfp 150 6 predominantly predominantly RB cord-006824-btcdjmfp 150 7 after after IN cord-006824-btcdjmfp 150 8 autologous autologous JJ cord-006824-btcdjmfp 150 9 transplantation transplantation NN cord-006824-btcdjmfp 150 10 [ [ -LRB- cord-006824-btcdjmfp 150 11 78 78 CD cord-006824-btcdjmfp 150 12 , , , cord-006824-btcdjmfp 150 13 2 2 CD cord-006824-btcdjmfp 150 14 ] ] -RRB- cord-006824-btcdjmfp 150 15 . . . cord-006824-btcdjmfp 151 1 Mortality mortality NN cord-006824-btcdjmfp 151 2 of of IN cord-006824-btcdjmfp 151 3 this this DT cord-006824-btcdjmfp 151 4 disorder disorder NN cord-006824-btcdjmfp 151 5 ranges range VBZ cord-006824-btcdjmfp 151 6 from from IN cord-006824-btcdjmfp 151 7 50 50 CD cord-006824-btcdjmfp 151 8 - - SYM cord-006824-btcdjmfp 151 9 80 80 CD cord-006824-btcdjmfp 151 10 % % NN cord-006824-btcdjmfp 151 11 . . . cord-006824-btcdjmfp 152 1 Nonspecific nonspecific JJ cord-006824-btcdjmfp 152 2 symptoms symptom NNS cord-006824-btcdjmfp 152 3 such such JJ cord-006824-btcdjmfp 152 4 as as IN cord-006824-btcdjmfp 152 5 progredient progredient NNP cord-006824-btcdjmfp 152 6 dyspnoea dyspnoea NNS cord-006824-btcdjmfp 152 7 , , , cord-006824-btcdjmfp 152 8 dry dry JJ cord-006824-btcdjmfp 152 9 cough cough NN cord-006824-btcdjmfp 152 10 , , , cord-006824-btcdjmfp 152 11 fever fever NN cord-006824-btcdjmfp 152 12 , , , cord-006824-btcdjmfp 152 13 hypoxia hypoxia NN cord-006824-btcdjmfp 152 14 and and CC cord-006824-btcdjmfp 152 15 diffuse diffuse VB cord-006824-btcdjmfp 152 16 lobular lobular JJ cord-006824-btcdjmfp 152 17 consolidation consolidation NN cord-006824-btcdjmfp 152 18 in in IN cord-006824-btcdjmfp 152 19 Xray Xray NNP cord-006824-btcdjmfp 152 20 are be VBP cord-006824-btcdjmfp 152 21 considered consider VBN cord-006824-btcdjmfp 152 22 typical typical JJ cord-006824-btcdjmfp 152 23 . . . cord-006824-btcdjmfp 153 1 Hemoptoe Hemoptoe NNP cord-006824-btcdjmfp 153 2 is be VBZ cord-006824-btcdjmfp 153 3 rare rare JJ cord-006824-btcdjmfp 153 4 . . . cord-006824-btcdjmfp 154 1 Early early JJ cord-006824-btcdjmfp 154 2 diagnosis diagnosis NN cord-006824-btcdjmfp 154 3 ( ( -LRB- cord-006824-btcdjmfp 154 4 BAL BAL NNP cord-006824-btcdjmfp 154 5 ) ) -RRB- cord-006824-btcdjmfp 154 6 is be VBZ cord-006824-btcdjmfp 154 7 important important JJ cord-006824-btcdjmfp 154 8 since since IN cord-006824-btcdjmfp 154 9 high high JJ cord-006824-btcdjmfp 154 10 - - HYPH cord-006824-btcdjmfp 154 11 dose dose NN cord-006824-btcdjmfp 154 12 corticosteroids corticosteroid NNS cord-006824-btcdjmfp 154 13 can can MD cord-006824-btcdjmfp 154 14 then then RB cord-006824-btcdjmfp 154 15 be be VB cord-006824-btcdjmfp 154 16 applied apply VBN cord-006824-btcdjmfp 154 17 efficiently efficiently RB cord-006824-btcdjmfp 154 18 [ [ -LRB- cord-006824-btcdjmfp 154 19 70 70 CD cord-006824-btcdjmfp 154 20 ] ] -RRB- cord-006824-btcdjmfp 154 21 . . . cord-006824-btcdjmfp 155 1 Because because IN cord-006824-btcdjmfp 155 2 of of IN cord-006824-btcdjmfp 155 3 its -PRON- PRP$ cord-006824-btcdjmfp 155 4 high high JJ cord-006824-btcdjmfp 155 5 mortality mortality NN cord-006824-btcdjmfp 155 6 , , , cord-006824-btcdjmfp 155 7 the the DT cord-006824-btcdjmfp 155 8 late late JJ cord-006824-btcdjmfp 155 9 complication complication NN cord-006824-btcdjmfp 155 10 " " '' cord-006824-btcdjmfp 155 11 bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 155 12 obliterans obliteran NNS cord-006824-btcdjmfp 155 13 " " '' cord-006824-btcdjmfp 155 14 ( ( -LRB- cord-006824-btcdjmfp 155 15 BO BO NNP cord-006824-btcdjmfp 155 16 ) ) -RRB- cord-006824-btcdjmfp 155 17 stands stand VBZ cord-006824-btcdjmfp 155 18 -together -together : cord-006824-btcdjmfp 155 19 with with IN cord-006824-btcdjmfp 155 20 non non JJ cord-006824-btcdjmfp 155 21 - - JJ cord-006824-btcdjmfp 155 22 classifiable classifiable JJ cord-006824-btcdjmfp 155 23 interstitial interstitial JJ cord-006824-btcdjmfp 155 24 pneumonia pneumonia NN cord-006824-btcdjmfp 155 25 , , , cord-006824-btcdjmfp 155 26 -in -in : cord-006824-btcdjmfp 155 27 the the DT cord-006824-btcdjmfp 155 28 first first JJ cord-006824-btcdjmfp 155 29 line line NN cord-006824-btcdjmfp 155 30 of of IN cord-006824-btcdjmfp 155 31 differential differential JJ cord-006824-btcdjmfp 155 32 diagnoses diagnosis NNS cord-006824-btcdjmfp 155 33 for for IN cord-006824-btcdjmfp 155 34 non non JJ cord-006824-btcdjmfp 155 35 - - JJ cord-006824-btcdjmfp 155 36 infectious infectious JJ cord-006824-btcdjmfp 155 37 pulmonary pulmonary JJ cord-006824-btcdjmfp 155 38 complications complication NNS cord-006824-btcdjmfp 155 39 after after IN cord-006824-btcdjmfp 155 40 HSCT HSCT NNP cord-006824-btcdjmfp 155 41 . . . cord-006824-btcdjmfp 156 1 Not not RB cord-006824-btcdjmfp 156 2 unlike unlike IN cord-006824-btcdjmfp 156 3 BO BO NNP cord-006824-btcdjmfp 156 4 after after IN cord-006824-btcdjmfp 156 5 lung lung NN cord-006824-btcdjmfp 156 6 transplantation transplantation NN cord-006824-btcdjmfp 156 7 , , , cord-006824-btcdjmfp 156 8 the the DT cord-006824-btcdjmfp 156 9 etiology etiology NN cord-006824-btcdjmfp 156 10 remains remain VBZ cord-006824-btcdjmfp 156 11 unclear unclear JJ cord-006824-btcdjmfp 156 12 . . . cord-006824-btcdjmfp 157 1 Lymphocyt Lymphocyt NNP cord-006824-btcdjmfp 157 2 - - HYPH cord-006824-btcdjmfp 157 3 ic ic NNP cord-006824-btcdjmfp 157 4 bronchitis bronchitis NN cord-006824-btcdjmfp 157 5 , , , cord-006824-btcdjmfp 157 6 alloreactivity alloreactivity NN cord-006824-btcdjmfp 157 7 after after IN cord-006824-btcdjmfp 157 8 pathologic pathologic JJ cord-006824-btcdjmfp 157 9 expression expression NN cord-006824-btcdjmfp 157 10 of of IN cord-006824-btcdjmfp 157 11 antigens antigen NNS cord-006824-btcdjmfp 157 12 due due IN cord-006824-btcdjmfp 157 13 to to IN cord-006824-btcdjmfp 157 14 stress stress NN cord-006824-btcdjmfp 157 15 ( ( -LRB- cord-006824-btcdjmfp 157 16 viral viral JJ cord-006824-btcdjmfp 157 17 , , , cord-006824-btcdjmfp 157 18 radiation radiation NN cord-006824-btcdjmfp 157 19 , , , cord-006824-btcdjmfp 157 20 medications medication NNS cord-006824-btcdjmfp 157 21 ) ) -RRB- cord-006824-btcdjmfp 157 22 , , , cord-006824-btcdjmfp 157 23 malnutrition malnutrition NN cord-006824-btcdjmfp 157 24 of of IN cord-006824-btcdjmfp 157 25 the the DT cord-006824-btcdjmfp 157 26 bronchial bronchial JJ cord-006824-btcdjmfp 157 27 wall wall NN cord-006824-btcdjmfp 157 28 , , , cord-006824-btcdjmfp 157 29 vascular vascular JJ cord-006824-btcdjmfp 157 30 changes change NNS cord-006824-btcdjmfp 157 31 , , , cord-006824-btcdjmfp 157 32 occult occult JJ cord-006824-btcdjmfp 157 33 aspirations aspiration NNS cord-006824-btcdjmfp 157 34 -are -are : cord-006824-btcdjmfp 157 35 all all DT cord-006824-btcdjmfp 157 36 considered consider VBN cord-006824-btcdjmfp 157 37 to to TO cord-006824-btcdjmfp 157 38 be be VB cord-006824-btcdjmfp 157 39 causative causative JJ cord-006824-btcdjmfp 157 40 events event NNS cord-006824-btcdjmfp 157 41 ( ( -LRB- cord-006824-btcdjmfp 157 42 71 71 CD cord-006824-btcdjmfp 157 43 ) ) -RRB- cord-006824-btcdjmfp 157 44 . . . cord-006824-btcdjmfp 158 1 Histologically histologically RB cord-006824-btcdjmfp 158 2 the the DT cord-006824-btcdjmfp 158 3 disease disease NN cord-006824-btcdjmfp 158 4 resembles resemble VBZ cord-006824-btcdjmfp 158 5 BO BO NNP cord-006824-btcdjmfp 158 6 in in IN cord-006824-btcdjmfp 158 7 patients patient NNS cord-006824-btcdjmfp 158 8 after after IN cord-006824-btcdjmfp 158 9 heart heart NN cord-006824-btcdjmfp 158 10 - - HYPH cord-006824-btcdjmfp 158 11 lung lung NN cord-006824-btcdjmfp 158 12 and and CC cord-006824-btcdjmfp 158 13 lung lung NN cord-006824-btcdjmfp 158 14 transplantation transplantation NN cord-006824-btcdjmfp 158 15 ; ; : cord-006824-btcdjmfp 158 16 it -PRON- PRP cord-006824-btcdjmfp 158 17 is be VBZ cord-006824-btcdjmfp 158 18 interpreted interpret VBN cord-006824-btcdjmfp 158 19 as as IN cord-006824-btcdjmfp 158 20 chronic chronic JJ cord-006824-btcdjmfp 158 21 rejection rejection NN cord-006824-btcdjmfp 158 22 ( ( -LRB- cord-006824-btcdjmfp 158 23 prevalence prevalence NN cord-006824-btcdjmfp 158 24 > > XX cord-006824-btcdjmfp 158 25 35 35 CD cord-006824-btcdjmfp 158 26 % % NN cord-006824-btcdjmfp 158 27 ) ) -RRB- cord-006824-btcdjmfp 158 28 with with IN cord-006824-btcdjmfp 158 29 high high JJ cord-006824-btcdjmfp 158 30 mortality mortality NN cord-006824-btcdjmfp 158 31 ( ( -LRB- cord-006824-btcdjmfp 158 32 25 25 CD cord-006824-btcdjmfp 158 33 % % NN cord-006824-btcdjmfp 158 34 ) ) -RRB- cord-006824-btcdjmfp 158 35 [ [ -LRB- cord-006824-btcdjmfp 158 36 79 79 CD cord-006824-btcdjmfp 158 37 ] ] -RRB- cord-006824-btcdjmfp 158 38 . . . cord-006824-btcdjmfp 159 1 The the DT cord-006824-btcdjmfp 159 2 first first JJ cord-006824-btcdjmfp 159 3 description description NN cord-006824-btcdjmfp 159 4 of of IN cord-006824-btcdjmfp 159 5 BO BO NNP cord-006824-btcdjmfp 159 6 after after IN cord-006824-btcdjmfp 159 7 allogeneic allogeneic IN cord-006824-btcdjmfp 159 8 hematopoetic hematopoetic JJ cord-006824-btcdjmfp 159 9 stem stem NN cord-006824-btcdjmfp 159 10 cell cell NN cord-006824-btcdjmfp 159 11 transplantation transplantation NN cord-006824-btcdjmfp 159 12 dates date NNS cord-006824-btcdjmfp 159 13 from from IN cord-006824-btcdjmfp 159 14 1982 1982 CD cord-006824-btcdjmfp 159 15 [ [ -LRB- cord-006824-btcdjmfp 159 16 66 66 CD cord-006824-btcdjmfp 159 17 ] ] -RRB- cord-006824-btcdjmfp 159 18 . . . cord-006824-btcdjmfp 160 1 Since since IN cord-006824-btcdjmfp 160 2 then then RB cord-006824-btcdjmfp 160 3 this this DT cord-006824-btcdjmfp 160 4 complication complication NN cord-006824-btcdjmfp 160 5 has have VBZ cord-006824-btcdjmfp 160 6 been be VBN cord-006824-btcdjmfp 160 7 described describe VBN cord-006824-btcdjmfp 160 8 after after IN cord-006824-btcdjmfp 160 9 all all DT cord-006824-btcdjmfp 160 10 types type NNS cord-006824-btcdjmfp 160 11 of of IN cord-006824-btcdjmfp 160 12 transplantation transplantation NN cord-006824-btcdjmfp 160 13 , , , cord-006824-btcdjmfp 160 14 including include VBG cord-006824-btcdjmfp 160 15 cord cord NN cord-006824-btcdjmfp 160 16 blood blood NN cord-006824-btcdjmfp 160 17 cell cell NN cord-006824-btcdjmfp 160 18 transplantation transplantation NN cord-006824-btcdjmfp 160 19 [ [ -LRB- cord-006824-btcdjmfp 160 20 57 57 CD cord-006824-btcdjmfp 160 21 ] ] -RRB- cord-006824-btcdjmfp 160 22 . . . cord-006824-btcdjmfp 161 1 In in IN cord-006824-btcdjmfp 161 2 adults adult NNS cord-006824-btcdjmfp 161 3 one one PRP cord-006824-btcdjmfp 161 4 assumes assume VBZ cord-006824-btcdjmfp 161 5 a a DT cord-006824-btcdjmfp 161 6 prevalence prevalence NN cord-006824-btcdjmfp 161 7 of of IN cord-006824-btcdjmfp 161 8 bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 161 9 obliterans obliterans NNP cord-006824-btcdjmfp 161 10 after after IN cord-006824-btcdjmfp 161 11 hematopoetic hematopoetic JJ cord-006824-btcdjmfp 161 12 stem stem NN cord-006824-btcdjmfp 161 13 cell cell NN cord-006824-btcdjmfp 161 14 transplantation transplantation NN cord-006824-btcdjmfp 161 15 in in IN cord-006824-btcdjmfp 161 16 a a DT cord-006824-btcdjmfp 161 17 range range NN cord-006824-btcdjmfp 161 18 between between IN cord-006824-btcdjmfp 161 19 5 5 CD cord-006824-btcdjmfp 161 20 - - SYM cord-006824-btcdjmfp 161 21 10 10 CD cord-006824-btcdjmfp 161 22 % % NN cord-006824-btcdjmfp 161 23 [ [ -LRB- cord-006824-btcdjmfp 161 24 62 62 CD cord-006824-btcdjmfp 161 25 , , , cord-006824-btcdjmfp 161 26 81 81 CD cord-006824-btcdjmfp 161 27 ] ] -RRB- cord-006824-btcdjmfp 161 28 . . . cord-006824-btcdjmfp 162 1 In in IN cord-006824-btcdjmfp 162 2 children child NNS cord-006824-btcdjmfp 162 3 , , , cord-006824-btcdjmfp 162 4 incidences incidence NNS cord-006824-btcdjmfp 162 5 of of IN cord-006824-btcdjmfp 162 6 up up IN cord-006824-btcdjmfp 162 7 to to TO cord-006824-btcdjmfp 162 8 20 20 CD cord-006824-btcdjmfp 162 9 % % NN cord-006824-btcdjmfp 162 10 have have VBP cord-006824-btcdjmfp 162 11 been be VBN cord-006824-btcdjmfp 162 12 reported report VBN cord-006824-btcdjmfp 162 13 [ [ -LRB- cord-006824-btcdjmfp 162 14 68 68 CD cord-006824-btcdjmfp 162 15 ] ] -RRB- cord-006824-btcdjmfp 162 16 . . . cord-006824-btcdjmfp 163 1 If if IN cord-006824-btcdjmfp 163 2 unrecognised unrecognised JJ cord-006824-btcdjmfp 163 3 , , , cord-006824-btcdjmfp 163 4 this this DT cord-006824-btcdjmfp 163 5 late late JJ cord-006824-btcdjmfp 163 6 complication complication NN cord-006824-btcdjmfp 163 7 tends tend VBZ cord-006824-btcdjmfp 163 8 to to TO cord-006824-btcdjmfp 163 9 be be VB cord-006824-btcdjmfp 163 10 lethal lethal JJ cord-006824-btcdjmfp 163 11 , , , cord-006824-btcdjmfp 163 12 since since IN cord-006824-btcdjmfp 163 13 the the DT cord-006824-btcdjmfp 163 14 therapeutic therapeutic JJ cord-006824-btcdjmfp 163 15 effect effect NN cord-006824-btcdjmfp 163 16 of of IN cord-006824-btcdjmfp 163 17 corticosteroids corticosteroid NNS cord-006824-btcdjmfp 163 18 in in IN cord-006824-btcdjmfp 163 19 advanced advanced JJ cord-006824-btcdjmfp 163 20 stages stage NNS cord-006824-btcdjmfp 163 21 is be VBZ cord-006824-btcdjmfp 163 22 poor poor JJ cord-006824-btcdjmfp 163 23 . . . cord-006824-btcdjmfp 164 1 The the DT cord-006824-btcdjmfp 164 2 speed speed NN cord-006824-btcdjmfp 164 3 of of IN cord-006824-btcdjmfp 164 4 progression progression NN cord-006824-btcdjmfp 164 5 for for IN cord-006824-btcdjmfp 164 6 BO BO NNP cord-006824-btcdjmfp 164 7 and and CC cord-006824-btcdjmfp 164 8 the the DT cord-006824-btcdjmfp 164 9 ideal ideal JJ cord-006824-btcdjmfp 164 10 time time NN cord-006824-btcdjmfp 164 11 for for IN cord-006824-btcdjmfp 164 12 therapeutic therapeutic JJ cord-006824-btcdjmfp 164 13 intervention intervention NN cord-006824-btcdjmfp 164 14 are be VBP cord-006824-btcdjmfp 164 15 unknown unknown JJ cord-006824-btcdjmfp 164 16 . . . cord-006824-btcdjmfp 165 1 BO BO NNP cord-006824-btcdjmfp 165 2 is be VBZ cord-006824-btcdjmfp 165 3 frequently frequently RB cord-006824-btcdjmfp 165 4 associated associate VBN cord-006824-btcdjmfp 165 5 with with IN cord-006824-btcdjmfp 165 6 chronic chronic JJ cord-006824-btcdjmfp 165 7 GVHD GVHD NNP cord-006824-btcdjmfp 165 8 [ [ -LRB- cord-006824-btcdjmfp 165 9 81 81 CD cord-006824-btcdjmfp 165 10 , , , cord-006824-btcdjmfp 165 11 60 60 CD cord-006824-btcdjmfp 165 12 ] ] -RRB- cord-006824-btcdjmfp 165 13 and and CC cord-006824-btcdjmfp 165 14 they -PRON- PRP cord-006824-btcdjmfp 165 15 occur occur VBP cord-006824-btcdjmfp 165 16 in in IN cord-006824-btcdjmfp 165 17 combination combination NN cord-006824-btcdjmfp 165 18 in in IN cord-006824-btcdjmfp 165 19 up up IN cord-006824-btcdjmfp 165 20 to to TO cord-006824-btcdjmfp 165 21 10 10 CD cord-006824-btcdjmfp 165 22 % % NN cord-006824-btcdjmfp 165 23 of of IN cord-006824-btcdjmfp 165 24 adult adult NN cord-006824-btcdjmfp 165 25 patients patient NNS cord-006824-btcdjmfp 165 26 [ [ -LRB- cord-006824-btcdjmfp 165 27 42 42 CD cord-006824-btcdjmfp 165 28 ] ] -RRB- cord-006824-btcdjmfp 165 29 and and CC cord-006824-btcdjmfp 165 30 up up IN cord-006824-btcdjmfp 165 31 to to TO cord-006824-btcdjmfp 165 32 30 30 CD cord-006824-btcdjmfp 165 33 % % NN cord-006824-btcdjmfp 165 34 in in IN cord-006824-btcdjmfp 165 35 children child NNS cord-006824-btcdjmfp 165 36 with with IN cord-006824-btcdjmfp 165 37 GVHD GVHD NNP cord-006824-btcdjmfp 165 38 [ [ -LRB- cord-006824-btcdjmfp 165 39 68 68 CD cord-006824-btcdjmfp 165 40 ] ] -RRB- cord-006824-btcdjmfp 165 41 . . . cord-006824-btcdjmfp 166 1 The the DT cord-006824-btcdjmfp 166 2 clinical clinical JJ cord-006824-btcdjmfp 166 3 symptoms symptom NNS cord-006824-btcdjmfp 166 4 are be VBP cord-006824-btcdjmfp 166 5 nonspecific nonspecific JJ cord-006824-btcdjmfp 166 6 with with IN cord-006824-btcdjmfp 166 7 expiratory expiratory JJ cord-006824-btcdjmfp 166 8 wheeze wheeze NN cord-006824-btcdjmfp 166 9 , , , cord-006824-btcdjmfp 166 10 cough cough NN cord-006824-btcdjmfp 166 11 , , , cord-006824-btcdjmfp 166 12 dyspnoea dyspnoea NNS cord-006824-btcdjmfp 166 13 and and CC cord-006824-btcdjmfp 166 14 hypoxia hypoxia NN cord-006824-btcdjmfp 166 15 upon upon IN cord-006824-btcdjmfp 166 16 exertion exertion NN cord-006824-btcdjmfp 166 17 . . . cord-006824-btcdjmfp 167 1 Typical typical JJ cord-006824-btcdjmfp 167 2 HR HR NNP cord-006824-btcdjmfp 167 3 - - HYPH cord-006824-btcdjmfp 167 4 CT ct NN cord-006824-btcdjmfp 167 5 - - HYPH cord-006824-btcdjmfp 167 6 signs sign NNS cord-006824-btcdjmfp 167 7 of of IN cord-006824-btcdjmfp 167 8 the the DT cord-006824-btcdjmfp 167 9 thorax thorax NN cord-006824-btcdjmfp 167 10 for for IN cord-006824-btcdjmfp 167 11 BO BO NNP cord-006824-btcdjmfp 167 12 are be VBP cord-006824-btcdjmfp 167 13 peripheral peripheral JJ cord-006824-btcdjmfp 167 14 hypovascularity hypovascularity NN cord-006824-btcdjmfp 167 15 , , , cord-006824-btcdjmfp 167 16 enlargement enlargement NN cord-006824-btcdjmfp 167 17 of of IN cord-006824-btcdjmfp 167 18 segmental segmental JJ cord-006824-btcdjmfp 167 19 - - HYPH cord-006824-btcdjmfp 167 20 and and CC cord-006824-btcdjmfp 167 21 subsegmental subsegmental JJ cord-006824-btcdjmfp 167 22 bronchi bronchi NN cord-006824-btcdjmfp 167 23 , , , cord-006824-btcdjmfp 167 24 fixed fix VBN cord-006824-btcdjmfp 167 25 hyperinflation hyperinflation NN cord-006824-btcdjmfp 167 26 ( ( -LRB- cord-006824-btcdjmfp 167 27 " " `` cord-006824-btcdjmfp 167 28 mosaic mosaic JJ cord-006824-btcdjmfp 167 29 pattern pattern NN cord-006824-btcdjmfp 167 30 " " '' cord-006824-btcdjmfp 167 31 ) ) -RRB- cord-006824-btcdjmfp 167 32 , , , cord-006824-btcdjmfp 167 33 and and CC cord-006824-btcdjmfp 167 34 deformed deformed JJ cord-006824-btcdjmfp 167 35 peripheral peripheral JJ cord-006824-btcdjmfp 167 36 vessels vessel NNS cord-006824-btcdjmfp 167 37 [ [ -LRB- cord-006824-btcdjmfp 167 38 31 31 CD cord-006824-btcdjmfp 167 39 , , , cord-006824-btcdjmfp 167 40 67 67 CD cord-006824-btcdjmfp 167 41 , , , cord-006824-btcdjmfp 167 42 6 6 CD cord-006824-btcdjmfp 167 43 , , , cord-006824-btcdjmfp 167 44 80 80 CD cord-006824-btcdjmfp 167 45 , , , cord-006824-btcdjmfp 167 46 35 35 CD cord-006824-btcdjmfp 167 47 , , , cord-006824-btcdjmfp 167 48 58 58 CD cord-006824-btcdjmfp 167 49 ] ] -RRB- cord-006824-btcdjmfp 167 50 . . . cord-006824-btcdjmfp 168 1 It -PRON- PRP cord-006824-btcdjmfp 168 2 is be VBZ cord-006824-btcdjmfp 168 3 debatable debatable JJ cord-006824-btcdjmfp 168 4 , , , cord-006824-btcdjmfp 168 5 however however RB cord-006824-btcdjmfp 168 6 , , , cord-006824-btcdjmfp 168 7 whether whether IN cord-006824-btcdjmfp 168 8 these these DT cord-006824-btcdjmfp 168 9 signs sign NNS cord-006824-btcdjmfp 168 10 are be VBP cord-006824-btcdjmfp 168 11 also also RB cord-006824-btcdjmfp 168 12 typical typical JJ cord-006824-btcdjmfp 168 13 for for IN cord-006824-btcdjmfp 168 14 BO BO NNP cord-006824-btcdjmfp 168 15 after after IN cord-006824-btcdjmfp 168 16 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 168 17 stem stem NN cord-006824-btcdjmfp 168 18 cell cell NN cord-006824-btcdjmfp 168 19 transplantation transplantation NN cord-006824-btcdjmfp 168 20 . . . cord-006824-btcdjmfp 169 1 Some some DT cord-006824-btcdjmfp 169 2 of of IN cord-006824-btcdjmfp 169 3 these these DT cord-006824-btcdjmfp 169 4 signs sign NNS cord-006824-btcdjmfp 169 5 can can MD cord-006824-btcdjmfp 169 6 only only RB cord-006824-btcdjmfp 169 7 be be VB cord-006824-btcdjmfp 169 8 interpreted interpret VBN cord-006824-btcdjmfp 169 9 correctly correctly RB cord-006824-btcdjmfp 169 10 if if IN cord-006824-btcdjmfp 169 11 sequential sequential JJ cord-006824-btcdjmfp 169 12 examinations examination NNS cord-006824-btcdjmfp 169 13 have have VBP cord-006824-btcdjmfp 169 14 been be VBN cord-006824-btcdjmfp 169 15 performed perform VBN cord-006824-btcdjmfp 169 16 . . . cord-006824-btcdjmfp 170 1 Furthermore furthermore RB cord-006824-btcdjmfp 170 2 , , , cord-006824-btcdjmfp 170 3 CT CT NNP cord-006824-btcdjmfp 170 4 studies study NNS cord-006824-btcdjmfp 170 5 in in IN cord-006824-btcdjmfp 170 6 children child NNS cord-006824-btcdjmfp 170 7 are be VBP cord-006824-btcdjmfp 170 8 rare rare JJ cord-006824-btcdjmfp 170 9 . . . cord-006824-btcdjmfp 171 1 In in IN cord-006824-btcdjmfp 171 2 BAL bal NN cord-006824-btcdjmfp 171 3 differential differential NN cord-006824-btcdjmfp 171 4 cytology cytology NN cord-006824-btcdjmfp 171 5 the the DT cord-006824-btcdjmfp 171 6 relative relative JJ cord-006824-btcdjmfp 171 7 number number NN cord-006824-btcdjmfp 171 8 of of IN cord-006824-btcdjmfp 171 9 neutrophils neutrophil NNS cord-006824-btcdjmfp 171 10 is be VBZ cord-006824-btcdjmfp 171 11 elevated elevate VBN cord-006824-btcdjmfp 171 12 [ [ -LRB- cord-006824-btcdjmfp 171 13 70 70 CD cord-006824-btcdjmfp 171 14 ] ] -RRB- cord-006824-btcdjmfp 171 15 . . . cord-006824-btcdjmfp 172 1 The the DT cord-006824-btcdjmfp 172 2 definite definite JJ cord-006824-btcdjmfp 172 3 diagnosis diagnosis NN cord-006824-btcdjmfp 172 4 of of IN cord-006824-btcdjmfp 172 5 bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 172 6 obliterans obliterans NNP cord-006824-btcdjmfp 172 7 can can MD cord-006824-btcdjmfp 172 8 frequently frequently RB cord-006824-btcdjmfp 172 9 only only RB cord-006824-btcdjmfp 172 10 be be VB cord-006824-btcdjmfp 172 11 achieved achieve VBN cord-006824-btcdjmfp 172 12 by by IN cord-006824-btcdjmfp 172 13 open open JJ cord-006824-btcdjmfp 172 14 lung lung NN cord-006824-btcdjmfp 172 15 biopsy biopsy NN cord-006824-btcdjmfp 172 16 . . . cord-006824-btcdjmfp 173 1 The the DT cord-006824-btcdjmfp 173 2 histopathological histopathological JJ cord-006824-btcdjmfp 173 3 finding finding NN cord-006824-btcdjmfp 173 4 is be VBZ cord-006824-btcdjmfp 173 5 bronchiolar bronchiolar JJ cord-006824-btcdjmfp 173 6 inflammation inflammation NN cord-006824-btcdjmfp 173 7 with with IN cord-006824-btcdjmfp 173 8 luminar luminar NNP cord-006824-btcdjmfp 173 9 scarring scarring NN cord-006824-btcdjmfp 173 10 , , , cord-006824-btcdjmfp 173 11 fibrous fibrous JJ cord-006824-btcdjmfp 173 12 tissue tissue NN cord-006824-btcdjmfp 173 13 and and CC cord-006824-btcdjmfp 173 14 obliteration obliteration NN cord-006824-btcdjmfp 173 15 of of IN cord-006824-btcdjmfp 173 16 the the DT cord-006824-btcdjmfp 173 17 small small JJ cord-006824-btcdjmfp 173 18 bronchioli bronchioli NN cord-006824-btcdjmfp 173 19 without without IN cord-006824-btcdjmfp 173 20 occluding occlude VBG cord-006824-btcdjmfp 173 21 the the DT cord-006824-btcdjmfp 173 22 alveolar alveolar NN cord-006824-btcdjmfp 173 23 ducts duct NNS cord-006824-btcdjmfp 173 24 . . . cord-006824-btcdjmfp 174 1 In in IN cord-006824-btcdjmfp 174 2 lung lung NN cord-006824-btcdjmfp 174 3 function function NN cord-006824-btcdjmfp 174 4 the the DT cord-006824-btcdjmfp 174 5 small small JJ cord-006824-btcdjmfp 174 6 airways airway NNS cord-006824-btcdjmfp 174 7 are be VBP cord-006824-btcdjmfp 174 8 affected affect VBN cord-006824-btcdjmfp 174 9 first first RB cord-006824-btcdjmfp 174 10 ( ( -LRB- cord-006824-btcdjmfp 174 11 hyperinflation hyperinflation NN cord-006824-btcdjmfp 174 12 ) ) -RRB- cord-006824-btcdjmfp 174 13 and and CC cord-006824-btcdjmfp 174 14 there there EX cord-006824-btcdjmfp 174 15 is be VBZ cord-006824-btcdjmfp 174 16 exercise exercise NN cord-006824-btcdjmfp 174 17 limitation limitation NN cord-006824-btcdjmfp 174 18 without without IN cord-006824-btcdjmfp 174 19 hypoxia hypoxia NN cord-006824-btcdjmfp 174 20 . . . cord-006824-btcdjmfp 175 1 The the DT cord-006824-btcdjmfp 175 2 involvement involvement NN cord-006824-btcdjmfp 175 3 of of IN cord-006824-btcdjmfp 175 4 vessels vessel NNS cord-006824-btcdjmfp 175 5 can can MD cord-006824-btcdjmfp 175 6 vary vary VB cord-006824-btcdjmfp 175 7 . . . cord-006824-btcdjmfp 176 1 Therapeutically therapeutically RB cord-006824-btcdjmfp 176 2 , , , cord-006824-btcdjmfp 176 3 systemic systemic JJ cord-006824-btcdjmfp 176 4 glucocorticosteroids glucocorticosteroid NNS cord-006824-btcdjmfp 176 5 , , , cord-006824-btcdjmfp 176 6 cyclophosphamide cyclophosphamide RB cord-006824-btcdjmfp 176 7 , , , cord-006824-btcdjmfp 176 8 azathioprine azathioprine NN cord-006824-btcdjmfp 176 9 , , , cord-006824-btcdjmfp 176 10 chloroquine chloroquine NN cord-006824-btcdjmfp 176 11 , , , cord-006824-btcdjmfp 176 12 glucocorticosteroid glucocorticosteroid NNP cord-006824-btcdjmfp 176 13 pulses pulse VBZ cord-006824-btcdjmfp 176 14 , , , cord-006824-btcdjmfp 176 15 cyclosporine cyclosporine NN cord-006824-btcdjmfp 176 16 , , , cord-006824-btcdjmfp 176 17 anti anti JJ cord-006824-btcdjmfp 176 18 - - JJ cord-006824-btcdjmfp 176 19 thymocyte thymocyte JJ cord-006824-btcdjmfp 176 20 globulin globulin NN cord-006824-btcdjmfp 176 21 , , , cord-006824-btcdjmfp 176 22 tacrolimus tacrolimus NNP cord-006824-btcdjmfp 176 23 , , , cord-006824-btcdjmfp 176 24 methotrexate methotrexate NNP cord-006824-btcdjmfp 176 25 , , , cord-006824-btcdjmfp 176 26 total total JJ cord-006824-btcdjmfp 176 27 lymphoid lymphoid JJ cord-006824-btcdjmfp 176 28 irradiation irradiation NN cord-006824-btcdjmfp 176 29 , , , cord-006824-btcdjmfp 176 30 thalidomide thalidomide NN cord-006824-btcdjmfp 176 31 , , , cord-006824-btcdjmfp 176 32 clofazimine clofazimine NNP cord-006824-btcdjmfp 176 33 , , , cord-006824-btcdjmfp 176 34 extracorporal extracorporal NNP cord-006824-btcdjmfp 176 35 photopheresis photopheresis NNP cord-006824-btcdjmfp 176 36 , , , cord-006824-btcdjmfp 176 37 humanized humanize VBD cord-006824-btcdjmfp 176 38 monoclonal monoclonal JJ cord-006824-btcdjmfp 176 39 anti anti JJ cord-006824-btcdjmfp 176 40 - - JJ cord-006824-btcdjmfp 176 41 IL-2 il-2 JJ cord-006824-btcdjmfp 176 42 receptor receptor NN cord-006824-btcdjmfp 176 43 antibodies antibody NNS cord-006824-btcdjmfp 176 44 are be VBP cord-006824-btcdjmfp 176 45 applied apply VBN cord-006824-btcdjmfp 176 46 in in IN cord-006824-btcdjmfp 176 47 BO BO NNP cord-006824-btcdjmfp 176 48 without without IN cord-006824-btcdjmfp 176 49 convincing convincing JJ cord-006824-btcdjmfp 176 50 success success NN cord-006824-btcdjmfp 176 51 . . . cord-006824-btcdjmfp 177 1 Furthermore furthermore RB cord-006824-btcdjmfp 177 2 , , , cord-006824-btcdjmfp 177 3 there there EX cord-006824-btcdjmfp 177 4 have have VBP cord-006824-btcdjmfp 177 5 been be VBN cord-006824-btcdjmfp 177 6 no no DT cord-006824-btcdjmfp 177 7 controlled control VBN cord-006824-btcdjmfp 177 8 studies study NNS cord-006824-btcdjmfp 177 9 of of IN cord-006824-btcdjmfp 177 10 any any DT cord-006824-btcdjmfp 177 11 of of IN cord-006824-btcdjmfp 177 12 the the DT cord-006824-btcdjmfp 177 13 above above RB cord-006824-btcdjmfp 177 14 - - HYPH cord-006824-btcdjmfp 177 15 mentioned mention VBN cord-006824-btcdjmfp 177 16 medications medication NNS cord-006824-btcdjmfp 177 17 . . . cord-006824-btcdjmfp 178 1 As as IN cord-006824-btcdjmfp 178 2 a a DT cord-006824-btcdjmfp 178 3 number number NN cord-006824-btcdjmfp 178 4 of of IN cord-006824-btcdjmfp 178 5 interstitial interstitial JJ cord-006824-btcdjmfp 178 6 diseases disease NNS cord-006824-btcdjmfp 178 7 in in IN cord-006824-btcdjmfp 178 8 childhood childhood NN cord-006824-btcdjmfp 178 9 have have VBP cord-006824-btcdjmfp 178 10 shown show VBN cord-006824-btcdjmfp 178 11 a a DT cord-006824-btcdjmfp 178 12 favourable favourable JJ cord-006824-btcdjmfp 178 13 response response NN cord-006824-btcdjmfp 178 14 [ [ -LRB- cord-006824-btcdjmfp 178 15 22 22 CD cord-006824-btcdjmfp 178 16 , , , cord-006824-btcdjmfp 178 17 61 61 CD cord-006824-btcdjmfp 178 18 , , , cord-006824-btcdjmfp 178 19 59 59 CD cord-006824-btcdjmfp 178 20 ] ] -RRB- cord-006824-btcdjmfp 178 21 , , , cord-006824-btcdjmfp 178 22 our -PRON- PRP$ cord-006824-btcdjmfp 178 23 approach approach NN cord-006824-btcdjmfp 178 24 is be VBZ cord-006824-btcdjmfp 178 25 to to TO cord-006824-btcdjmfp 178 26 try try VB cord-006824-btcdjmfp 178 27 to to TO cord-006824-btcdjmfp 178 28 detect detect VB cord-006824-btcdjmfp 178 29 the the DT cord-006824-btcdjmfp 178 30 disease disease NN cord-006824-btcdjmfp 178 31 at at IN cord-006824-btcdjmfp 178 32 an an DT cord-006824-btcdjmfp 178 33 incipient incipient JJ cord-006824-btcdjmfp 178 34 stage stage NN cord-006824-btcdjmfp 178 35 and and CC cord-006824-btcdjmfp 178 36 use use VB cord-006824-btcdjmfp 178 37 methylprednisolone methylprednisolone NN cord-006824-btcdjmfp 178 38 pulse pulse NN cord-006824-btcdjmfp 178 39 therapy therapy NN cord-006824-btcdjmfp 178 40 as as IN cord-006824-btcdjmfp 178 41 a a DT cord-006824-btcdjmfp 178 42 first first JJ cord-006824-btcdjmfp 178 43 - - HYPH cord-006824-btcdjmfp 178 44 line line NN cord-006824-btcdjmfp 178 45 treatment treatment NN cord-006824-btcdjmfp 178 46 ( ( -LRB- cord-006824-btcdjmfp 178 47 32 32 CD cord-006824-btcdjmfp 178 48 ) ) -RRB- cord-006824-btcdjmfp 178 49 . . . cord-006824-btcdjmfp 179 1 In in IN cord-006824-btcdjmfp 179 2 about about RB cord-006824-btcdjmfp 179 3 30 30 CD cord-006824-btcdjmfp 179 4 - - SYM cord-006824-btcdjmfp 179 5 50 50 CD cord-006824-btcdjmfp 179 6 % % NN cord-006824-btcdjmfp 179 7 of of IN cord-006824-btcdjmfp 179 8 cases case NNS cord-006824-btcdjmfp 179 9 , , , cord-006824-btcdjmfp 179 10 at at IN cord-006824-btcdjmfp 179 11 least least JJS cord-006824-btcdjmfp 179 12 a a DT cord-006824-btcdjmfp 179 13 temporary temporary JJ cord-006824-btcdjmfp 179 14 response response NN cord-006824-btcdjmfp 179 15 can can MD cord-006824-btcdjmfp 179 16 be be VB cord-006824-btcdjmfp 179 17 seen see VBN cord-006824-btcdjmfp 179 18 . . . cord-006824-btcdjmfp 180 1 Unfortunately unfortunately RB cord-006824-btcdjmfp 180 2 , , , cord-006824-btcdjmfp 180 3 the the DT cord-006824-btcdjmfp 180 4 time time NN cord-006824-btcdjmfp 180 5 window window NN cord-006824-btcdjmfp 180 6 for for IN cord-006824-btcdjmfp 180 7 intervention intervention NN cord-006824-btcdjmfp 180 8 is be VBZ cord-006824-btcdjmfp 180 9 small small JJ cord-006824-btcdjmfp 180 10 in in IN cord-006824-btcdjmfp 180 11 most most JJS cord-006824-btcdjmfp 180 12 cases case NNS cord-006824-btcdjmfp 180 13 and and CC cord-006824-btcdjmfp 180 14 the the DT cord-006824-btcdjmfp 180 15 speed speed NN cord-006824-btcdjmfp 180 16 of of IN cord-006824-btcdjmfp 180 17 progression progression NN cord-006824-btcdjmfp 180 18 extremely extremely RB cord-006824-btcdjmfp 180 19 variable variable JJ cord-006824-btcdjmfp 180 20 , , , cord-006824-btcdjmfp 180 21 rendering rendering JJ cord-006824-btcdjmfp 180 22 evaluation evaluation NN cord-006824-btcdjmfp 180 23 of of IN cord-006824-btcdjmfp 180 24 therapeutic therapeutic JJ cord-006824-btcdjmfp 180 25 success success NN cord-006824-btcdjmfp 180 26 difficult difficult JJ cord-006824-btcdjmfp 180 27 . . . cord-006824-btcdjmfp 181 1 Complications complication NNS cord-006824-btcdjmfp 181 2 of of IN cord-006824-btcdjmfp 181 3 BO BO NNP cord-006824-btcdjmfp 181 4 are be VBP cord-006824-btcdjmfp 181 5 pneumothorax pneumothorax NN cord-006824-btcdjmfp 181 6 , , , cord-006824-btcdjmfp 181 7 pneumomediastinum pneumomediastinum NNP cord-006824-btcdjmfp 181 8 , , , cord-006824-btcdjmfp 181 9 bronchiectases bronchiectases NNP cord-006824-btcdjmfp 181 10 , , , cord-006824-btcdjmfp 181 11 hypercapnia hypercapnia NN cord-006824-btcdjmfp 181 12 and and CC cord-006824-btcdjmfp 181 13 pulmonary pulmonary JJ cord-006824-btcdjmfp 181 14 hypertension hypertension NN cord-006824-btcdjmfp 181 15 with with IN cord-006824-btcdjmfp 181 16 cardiac cardiac JJ cord-006824-btcdjmfp 181 17 failure failure NN cord-006824-btcdjmfp 181 18 . . . cord-006824-btcdjmfp 182 1 The the DT cord-006824-btcdjmfp 182 2 " " `` cord-006824-btcdjmfp 182 3 bronchiolitis bronchiolitis NNP cord-006824-btcdjmfp 182 4 obliterans obliterans NNP cord-006824-btcdjmfp 182 5 organizing organize VBG cord-006824-btcdjmfp 182 6 peumonia peumonia NNP cord-006824-btcdjmfp 182 7 " " '' cord-006824-btcdjmfp 182 8 ( ( -LRB- cord-006824-btcdjmfp 182 9 BOOP BOOP NNP cord-006824-btcdjmfp 182 10 ) ) -RRB- cord-006824-btcdjmfp 182 11 , , , cord-006824-btcdjmfp 182 12 which which WDT cord-006824-btcdjmfp 182 13 occurs occur VBZ cord-006824-btcdjmfp 182 14 more more RBR cord-006824-btcdjmfp 182 15 rarely rarely RB cord-006824-btcdjmfp 182 16 , , , cord-006824-btcdjmfp 182 17 was be VBD cord-006824-btcdjmfp 182 18 defined define VBN cord-006824-btcdjmfp 182 19 1985 1985 CD cord-006824-btcdjmfp 182 20 by by IN cord-006824-btcdjmfp 182 21 Epler Epler NNP cord-006824-btcdjmfp 182 22 [ [ -LRB- cord-006824-btcdjmfp 182 23 24 24 CD cord-006824-btcdjmfp 182 24 ] ] -RRB- cord-006824-btcdjmfp 182 25 . . . cord-006824-btcdjmfp 183 1 The the DT cord-006824-btcdjmfp 183 2 etiology etiology NN cord-006824-btcdjmfp 183 3 remains remain VBZ cord-006824-btcdjmfp 183 4 unclear unclear JJ cord-006824-btcdjmfp 183 5 . . . cord-006824-btcdjmfp 184 1 In in IN cord-006824-btcdjmfp 184 2 the the DT cord-006824-btcdjmfp 184 3 literature literature NN cord-006824-btcdjmfp 184 4 BOOP BOOP NNP cord-006824-btcdjmfp 184 5 has have VBZ cord-006824-btcdjmfp 184 6 been be VBN cord-006824-btcdjmfp 184 7 described describe VBN cord-006824-btcdjmfp 184 8 in in IN cord-006824-btcdjmfp 184 9 autoimmune autoimmune JJ cord-006824-btcdjmfp 184 10 diseases disease NNS cord-006824-btcdjmfp 184 11 , , , cord-006824-btcdjmfp 184 12 after after IN cord-006824-btcdjmfp 184 13 medication medication NN cord-006824-btcdjmfp 184 14 , , , cord-006824-btcdjmfp 184 15 as as RB cord-006824-btcdjmfp 184 16 well well RB cord-006824-btcdjmfp 184 17 as as IN cord-006824-btcdjmfp 184 18 with with IN cord-006824-btcdjmfp 184 19 viral viral JJ cord-006824-btcdjmfp 184 20 and and CC cord-006824-btcdjmfp 184 21 bacterial bacterial JJ cord-006824-btcdjmfp 184 22 infection infection NN cord-006824-btcdjmfp 184 23 and and CC cord-006824-btcdjmfp 184 24 as as IN cord-006824-btcdjmfp 184 25 idiopathic idiopathic JJ cord-006824-btcdjmfp 184 26 BOOP BOOP NNP cord-006824-btcdjmfp 184 27 [ [ -LRB- cord-006824-btcdjmfp 184 28 18 18 CD cord-006824-btcdjmfp 184 29 ] ] -RRB- cord-006824-btcdjmfp 184 30 . . . cord-006824-btcdjmfp 185 1 Lately lately RB cord-006824-btcdjmfp 185 2 a a DT cord-006824-btcdjmfp 185 3 number number NN cord-006824-btcdjmfp 185 4 of of IN cord-006824-btcdjmfp 185 5 cases case NNS cord-006824-btcdjmfp 185 6 have have VBP cord-006824-btcdjmfp 185 7 been be VBN cord-006824-btcdjmfp 185 8 published publish VBN cord-006824-btcdjmfp 185 9 after after IN cord-006824-btcdjmfp 185 10 HSCT HSCT NNP cord-006824-btcdjmfp 185 11 with with IN cord-006824-btcdjmfp 185 12 GVHD GVHD NNP cord-006824-btcdjmfp 185 13 [ [ -LRB- cord-006824-btcdjmfp 185 14 44 44 CD cord-006824-btcdjmfp 185 15 , , , cord-006824-btcdjmfp 185 16 48 48 CD cord-006824-btcdjmfp 185 17 , , , cord-006824-btcdjmfp 185 18 74 74 CD cord-006824-btcdjmfp 185 19 , , , cord-006824-btcdjmfp 185 20 40 40 CD cord-006824-btcdjmfp 185 21 ] ] -RRB- cord-006824-btcdjmfp 185 22 . . . cord-006824-btcdjmfp 186 1 There there EX cord-006824-btcdjmfp 186 2 are be VBP cord-006824-btcdjmfp 186 3 also also RB cord-006824-btcdjmfp 186 4 reports report NNS cord-006824-btcdjmfp 186 5 on on IN cord-006824-btcdjmfp 186 6 early early JJ cord-006824-btcdjmfp 186 7 and and CC cord-006824-btcdjmfp 186 8 fulminant fulminant JJ cord-006824-btcdjmfp 186 9 courses course NNS cord-006824-btcdjmfp 186 10 [ [ -LRB- cord-006824-btcdjmfp 186 11 55 55 CD cord-006824-btcdjmfp 186 12 , , , cord-006824-btcdjmfp 186 13 16 16 CD cord-006824-btcdjmfp 186 14 , , , cord-006824-btcdjmfp 186 15 82 82 CD cord-006824-btcdjmfp 186 16 ] ] -RRB- cord-006824-btcdjmfp 186 17 . . . cord-006824-btcdjmfp 187 1 The the DT cord-006824-btcdjmfp 187 2 clinical clinical JJ cord-006824-btcdjmfp 187 3 picture picture NN cord-006824-btcdjmfp 187 4 is be VBZ cord-006824-btcdjmfp 187 5 non non JJ cord-006824-btcdjmfp 187 6 - - JJ cord-006824-btcdjmfp 187 7 specific specific JJ cord-006824-btcdjmfp 187 8 , , , cord-006824-btcdjmfp 187 9 with with IN cord-006824-btcdjmfp 187 10 cough cough NN cord-006824-btcdjmfp 187 11 , , , cord-006824-btcdjmfp 187 12 dyspnea dyspnea NN cord-006824-btcdjmfp 187 13 , , , cord-006824-btcdjmfp 187 14 and and CC cord-006824-btcdjmfp 187 15 hypoxia hypoxia NN cord-006824-btcdjmfp 187 16 . . . cord-006824-btcdjmfp 188 1 Lung lung NN cord-006824-btcdjmfp 188 2 function function NN cord-006824-btcdjmfp 188 3 shows show VBZ cord-006824-btcdjmfp 188 4 a a DT cord-006824-btcdjmfp 188 5 restrictive restrictive JJ cord-006824-btcdjmfp 188 6 pattern pattern NN cord-006824-btcdjmfp 188 7 and and CC cord-006824-btcdjmfp 188 8 impairied impairie VBN cord-006824-btcdjmfp 188 9 diffusion diffusion NN cord-006824-btcdjmfp 188 10 capacity capacity NN cord-006824-btcdjmfp 188 11 . . . cord-006824-btcdjmfp 189 1 Histopathology Histopathology NNP cord-006824-btcdjmfp 189 2 demonstrates demonstrate VBZ cord-006824-btcdjmfp 189 3 granulation granulation NN cord-006824-btcdjmfp 189 4 -and -and HYPH cord-006824-btcdjmfp 189 5 fibrous fibrous JJ cord-006824-btcdjmfp 189 6 tissue tissue NN cord-006824-btcdjmfp 189 7 in in IN cord-006824-btcdjmfp 189 8 terminal terminal JJ cord-006824-btcdjmfp 189 9 bronchioles bronchiole NNS cord-006824-btcdjmfp 189 10 reaching reach VBG cord-006824-btcdjmfp 189 11 into into IN cord-006824-btcdjmfp 189 12 alveoli alveolus NNS cord-006824-btcdjmfp 189 13 -as -as . cord-006824-btcdjmfp 190 1 well well RB cord-006824-btcdjmfp 190 2 as as IN cord-006824-btcdjmfp 190 3 interstitial interstitial JJ cord-006824-btcdjmfp 190 4 lymphocytic lymphocytic JJ cord-006824-btcdjmfp 190 5 inflammation inflammation NN cord-006824-btcdjmfp 190 6 . . . cord-006824-btcdjmfp 191 1 Cellular cellular JJ cord-006824-btcdjmfp 191 2 profiles profile NNS cord-006824-btcdjmfp 191 3 of of IN cord-006824-btcdjmfp 191 4 BAL BAL NNP cord-006824-btcdjmfp 191 5 show show VBP cord-006824-btcdjmfp 191 6 high high JJ cord-006824-btcdjmfp 191 7 lymphocyte lymphocyte NN cord-006824-btcdjmfp 191 8 counts count NNS cord-006824-btcdjmfp 191 9 , , , cord-006824-btcdjmfp 191 10 with with IN cord-006824-btcdjmfp 191 11 low low JJ cord-006824-btcdjmfp 191 12 CD4 CD4 NNP cord-006824-btcdjmfp 191 13 / / SYM cord-006824-btcdjmfp 191 14 CD8-ratio CD8-ratio NNP cord-006824-btcdjmfp 191 15 ( ( -LRB- cord-006824-btcdjmfp 191 16 results result NNS cord-006824-btcdjmfp 191 17 from from IN cord-006824-btcdjmfp 191 18 adults adult NNS cord-006824-btcdjmfp 191 19 ) ) -RRB- cord-006824-btcdjmfp 191 20 [ [ -LRB- cord-006824-btcdjmfp 191 21 64 64 CD cord-006824-btcdjmfp 191 22 ] ] -RRB- cord-006824-btcdjmfp 191 23 . . . cord-006824-btcdjmfp 192 1 Characteristic characteristic JJ cord-006824-btcdjmfp 192 2 HR HR NNP cord-006824-btcdjmfp 192 3 - - HYPH cord-006824-btcdjmfp 192 4 CT ct NN cord-006824-btcdjmfp 192 5 - - HYPH cord-006824-btcdjmfp 192 6 patterns pattern NNS cord-006824-btcdjmfp 192 7 in in IN cord-006824-btcdjmfp 192 8 BOOP BOOP NNP cord-006824-btcdjmfp 192 9 are be VBP cord-006824-btcdjmfp 192 10 ground ground NN cord-006824-btcdjmfp 192 11 - - HYPH cord-006824-btcdjmfp 192 12 glass glass NN cord-006824-btcdjmfp 192 13 opacification opacification NN cord-006824-btcdjmfp 192 14 and and CC cord-006824-btcdjmfp 192 15 nodular nodular JJ cord-006824-btcdjmfp 192 16 shadows shadow NNS cord-006824-btcdjmfp 192 17 [ [ -LRB- cord-006824-btcdjmfp 192 18 29 29 CD cord-006824-btcdjmfp 192 19 ] ] -RRB- cord-006824-btcdjmfp 192 20 . . . cord-006824-btcdjmfp 193 1 Typical typical JJ cord-006824-btcdjmfp 193 2 bilateral bilateral JJ cord-006824-btcdjmfp 193 3 , , , cord-006824-btcdjmfp 193 4 focal focal JJ cord-006824-btcdjmfp 193 5 , , , cord-006824-btcdjmfp 193 6 predominantly predominantly RB cord-006824-btcdjmfp 193 7 peripheral peripheral JJ cord-006824-btcdjmfp 193 8 infiltrates infiltrate NNS cord-006824-btcdjmfp 193 9 can can MD cord-006824-btcdjmfp 193 10 be be VB cord-006824-btcdjmfp 193 11 detected detect VBN cord-006824-btcdjmfp 193 12 earlier early RBR cord-006824-btcdjmfp 193 13 using use VBG cord-006824-btcdjmfp 193 14 HR HR NNP cord-006824-btcdjmfp 193 15 - - HYPH cord-006824-btcdjmfp 193 16 CT CT NNP cord-006824-btcdjmfp 193 17 rather rather RB cord-006824-btcdjmfp 193 18 than than IN cord-006824-btcdjmfp 193 19 by by IN cord-006824-btcdjmfp 193 20 X x NN cord-006824-btcdjmfp 193 21 - - NN cord-006824-btcdjmfp 193 22 ray ray NN cord-006824-btcdjmfp 193 23 of of IN cord-006824-btcdjmfp 193 24 the the DT cord-006824-btcdjmfp 193 25 thorax thorax NN cord-006824-btcdjmfp 193 26 [ [ -LRB- cord-006824-btcdjmfp 193 27 51 51 CD cord-006824-btcdjmfp 193 28 , , , cord-006824-btcdjmfp 193 29 46 46 CD cord-006824-btcdjmfp 193 30 ] ] -RRB- cord-006824-btcdjmfp 193 31 . . . cord-006824-btcdjmfp 194 1 In in IN cord-006824-btcdjmfp 194 2 the the DT cord-006824-btcdjmfp 194 3 literature literature NN cord-006824-btcdjmfp 194 4 ( ( -LRB- cord-006824-btcdjmfp 194 5 including include VBG cord-006824-btcdjmfp 194 6 patients patient NNS cord-006824-btcdjmfp 194 7 after after IN cord-006824-btcdjmfp 194 8 HSCT HSCT NNP cord-006824-btcdjmfp 194 9 ) ) -RRB- cord-006824-btcdjmfp 195 1 the the DT cord-006824-btcdjmfp 195 2 beneficial beneficial JJ cord-006824-btcdjmfp 195 3 effect effect NN cord-006824-btcdjmfp 195 4 of of IN cord-006824-btcdjmfp 195 5 treatment treatment NN cord-006824-btcdjmfp 195 6 with with IN cord-006824-btcdjmfp 195 7 glucocorticosteroids glucocorticosteroids NNP cord-006824-btcdjmfp 195 8 is be VBZ cord-006824-btcdjmfp 195 9 emphasized emphasize VBN cord-006824-btcdjmfp 195 10 beginning begin VBG cord-006824-btcdjmfp 195 11 at at IN cord-006824-btcdjmfp 195 12 an an DT cord-006824-btcdjmfp 195 13 early early JJ cord-006824-btcdjmfp 195 14 stage stage NN cord-006824-btcdjmfp 195 15 and and CC cord-006824-btcdjmfp 195 16 continuing continue VBG cord-006824-btcdjmfp 195 17 for for IN cord-006824-btcdjmfp 195 18 6 6 CD cord-006824-btcdjmfp 195 19 - - SYM cord-006824-btcdjmfp 195 20 12 12 CD cord-006824-btcdjmfp 195 21 months month NNS cord-006824-btcdjmfp 195 22 ( ( -LRB- cord-006824-btcdjmfp 195 23 18 18 CD cord-006824-btcdjmfp 195 24 , , , cord-006824-btcdjmfp 195 25 40 40 CD cord-006824-btcdjmfp 195 26 , , , cord-006824-btcdjmfp 195 27 44 44 CD cord-006824-btcdjmfp 195 28 , , , cord-006824-btcdjmfp 195 29 48 48 CD cord-006824-btcdjmfp 195 30 , , , cord-006824-btcdjmfp 195 31 50 50 CD cord-006824-btcdjmfp 195 32 , , , cord-006824-btcdjmfp 195 33 75 75 CD cord-006824-btcdjmfp 195 34 ) ) -RRB- cord-006824-btcdjmfp 195 35 . . . cord-006824-btcdjmfp 196 1 Bronchiolitis Bronchiolitis NNP cord-006824-btcdjmfp 196 2 obliterans obliteran NNS cord-006824-btcdjmfp 196 3 organizing organize VBG cord-006824-btcdjmfp 196 4 pneumonia pneumonia NN cord-006824-btcdjmfp 196 5 ( ( -LRB- cord-006824-btcdjmfp 196 6 BOOP BOOP NNP cord-006824-btcdjmfp 196 7 ) ) -RRB- cord-006824-btcdjmfp 196 8 must must MD cord-006824-btcdjmfp 196 9 be be VB cord-006824-btcdjmfp 196 10 separated separate VBN cord-006824-btcdjmfp 196 11 diagnostically diagnostically RB cord-006824-btcdjmfp 196 12 from from IN cord-006824-btcdjmfp 196 13 " " `` cord-006824-btcdjmfp 196 14 lymphocytic lymphocytic JJ cord-006824-btcdjmfp 196 15 interstitial interstitial JJ cord-006824-btcdjmfp 196 16 pneumonia pneumonia NN cord-006824-btcdjmfp 196 17 ( ( -LRB- cord-006824-btcdjmfp 196 18 LIP LIP NNP cord-006824-btcdjmfp 196 19 ) ) -RRB- cord-006824-btcdjmfp 196 20 " " '' cord-006824-btcdjmfp 196 21 , , , cord-006824-btcdjmfp 196 22 " " `` cord-006824-btcdjmfp 196 23 diffuse diffuse VB cord-006824-btcdjmfp 196 24 alveolar alveolar NN cord-006824-btcdjmfp 196 25 damage damage NN cord-006824-btcdjmfp 196 26 " " '' cord-006824-btcdjmfp 196 27 ( ( -LRB- cord-006824-btcdjmfp 196 28 DAD DAD NNP cord-006824-btcdjmfp 196 29 ) ) -RRB- cord-006824-btcdjmfp 196 30 and and CC cord-006824-btcdjmfp 196 31 " " `` cord-006824-btcdjmfp 196 32 lung lung NN cord-006824-btcdjmfp 196 33 fibrosis fibrosis NN cord-006824-btcdjmfp 196 34 " " '' cord-006824-btcdjmfp 196 35 as as RB cord-006824-btcdjmfp 196 36 well well RB cord-006824-btcdjmfp 196 37 as as IN cord-006824-btcdjmfp 196 38 a a DT cord-006824-btcdjmfp 196 39 NSID NSID NNP cord-006824-btcdjmfp 196 40 ( ( -LRB- cord-006824-btcdjmfp 196 41 nonspecific nonspecific JJ cord-006824-btcdjmfp 196 42 interstitial interstitial JJ cord-006824-btcdjmfp 196 43 disease disease NN cord-006824-btcdjmfp 196 44 ) ) -RRB- cord-006824-btcdjmfp 196 45 and and CC cord-006824-btcdjmfp 196 46 pulmonary pulmonary JJ cord-006824-btcdjmfp 196 47 veno veno NN cord-006824-btcdjmfp 196 48 - - HYPH cord-006824-btcdjmfp 196 49 occlusive occlusive JJ cord-006824-btcdjmfp 196 50 disease disease NN cord-006824-btcdjmfp 196 51 ( ( -LRB- cord-006824-btcdjmfp 196 52 42 42 CD cord-006824-btcdjmfp 196 53 , , , cord-006824-btcdjmfp 196 54 77 77 CD cord-006824-btcdjmfp 196 55 , , , cord-006824-btcdjmfp 196 56 3 3 CD cord-006824-btcdjmfp 196 57 , , , cord-006824-btcdjmfp 196 58 4 4 CD cord-006824-btcdjmfp 196 59 ) ) -RRB- cord-006824-btcdjmfp 196 60 . . . cord-006824-btcdjmfp 197 1 These these DT cord-006824-btcdjmfp 197 2 diseases disease NNS cord-006824-btcdjmfp 197 3 tend tend VBP cord-006824-btcdjmfp 197 4 to to TO cord-006824-btcdjmfp 197 5 occur occur VB cord-006824-btcdjmfp 197 6 after after IN cord-006824-btcdjmfp 197 7 hematologic hematologic JJ cord-006824-btcdjmfp 197 8 diseases disease NNS cord-006824-btcdjmfp 197 9 , , , cord-006824-btcdjmfp 197 10 infections infection NNS cord-006824-btcdjmfp 197 11 and and CC cord-006824-btcdjmfp 197 12 therapeutical therapeutical JJ cord-006824-btcdjmfp 197 13 interventions intervention NNS cord-006824-btcdjmfp 197 14 ( ( -LRB- cord-006824-btcdjmfp 197 15 radiation radiation NN cord-006824-btcdjmfp 197 16 , , , cord-006824-btcdjmfp 197 17 chemotherapy chemotherapy NN cord-006824-btcdjmfp 197 18 ) ) -RRB- cord-006824-btcdjmfp 197 19 . . . cord-006824-btcdjmfp 198 1 Some some DT cord-006824-btcdjmfp 198 2 of of IN cord-006824-btcdjmfp 198 3 them -PRON- PRP cord-006824-btcdjmfp 198 4 are be VBP cord-006824-btcdjmfp 198 5 termed term VBN cord-006824-btcdjmfp 198 6 as as IN cord-006824-btcdjmfp 198 7 late late JJ cord-006824-btcdjmfp 198 8 onset onset NN cord-006824-btcdjmfp 198 9 non non JJ cord-006824-btcdjmfp 198 10 specific specific JJ cord-006824-btcdjmfp 198 11 interstitial interstitial JJ cord-006824-btcdjmfp 198 12 lung lung NN cord-006824-btcdjmfp 198 13 disease disease NN cord-006824-btcdjmfp 198 14 ( ( -LRB- cord-006824-btcdjmfp 198 15 LONSILD LONSILD NNP cord-006824-btcdjmfp 198 16 ) ) -RRB- cord-006824-btcdjmfp 198 17 . . . cord-006824-btcdjmfp 199 1 Prognosis prognosis NN cord-006824-btcdjmfp 199 2 varies vary VBZ cord-006824-btcdjmfp 199 3 greatly greatly RB cord-006824-btcdjmfp 199 4 . . . cord-006824-btcdjmfp 200 1 Treatment treatment NN cord-006824-btcdjmfp 200 2 modalities modality NNS cord-006824-btcdjmfp 200 3 range range VBP cord-006824-btcdjmfp 200 4 from from IN cord-006824-btcdjmfp 200 5 antioxidants antioxidant NNS cord-006824-btcdjmfp 200 6 to to IN cord-006824-btcdjmfp 200 7 supportive supportive JJ cord-006824-btcdjmfp 200 8 care care NN cord-006824-btcdjmfp 200 9 ( ( -LRB- cord-006824-btcdjmfp 200 10 oxygen oxygen NN cord-006824-btcdjmfp 200 11 ) ) -RRB- cord-006824-btcdjmfp 200 12 ( ( -LRB- cord-006824-btcdjmfp 200 13 72 72 CD cord-006824-btcdjmfp 200 14 ) ) -RRB- cord-006824-btcdjmfp 200 15 . . . cord-006824-btcdjmfp 201 1 With with IN cord-006824-btcdjmfp 201 2 severe severe JJ cord-006824-btcdjmfp 201 3 progression progression NN cord-006824-btcdjmfp 201 4 , , , cord-006824-btcdjmfp 201 5 the the DT cord-006824-btcdjmfp 201 6 only only JJ cord-006824-btcdjmfp 201 7 chance chance NN cord-006824-btcdjmfp 201 8 for for IN cord-006824-btcdjmfp 201 9 survival survival NN cord-006824-btcdjmfp 201 10 may may MD cord-006824-btcdjmfp 201 11 be be VB cord-006824-btcdjmfp 201 12 lung lung NN cord-006824-btcdjmfp 201 13 transplantation transplantation NN cord-006824-btcdjmfp 201 14 . . . cord-006824-btcdjmfp 202 1 Post post JJ cord-006824-btcdjmfp 202 2 transplant transplant NN cord-006824-btcdjmfp 202 3 lymphoproliferative lymphoproliferative JJ cord-006824-btcdjmfp 202 4 disease disease NN cord-006824-btcdjmfp 202 5 ( ( -LRB- cord-006824-btcdjmfp 202 6 PTLPD PTLPD NNP cord-006824-btcdjmfp 202 7 ) ) -RRB- cord-006824-btcdjmfp 202 8 can can MD cord-006824-btcdjmfp 202 9 manifest manifest VB cord-006824-btcdjmfp 202 10 itself -PRON- PRP cord-006824-btcdjmfp 202 11 in in IN cord-006824-btcdjmfp 202 12 the the DT cord-006824-btcdjmfp 202 13 lung lung NN cord-006824-btcdjmfp 202 14 and and CC cord-006824-btcdjmfp 202 15 can can MD cord-006824-btcdjmfp 202 16 occur occur VB cord-006824-btcdjmfp 202 17 any any DT cord-006824-btcdjmfp 202 18 time time NN cord-006824-btcdjmfp 202 19 after after IN cord-006824-btcdjmfp 202 20 transplantation transplantation NN cord-006824-btcdjmfp 202 21 . . . cord-006824-btcdjmfp 203 1 Frequency frequency NN cord-006824-btcdjmfp 203 2 varies vary VBZ cord-006824-btcdjmfp 203 3 depending depend VBG cord-006824-btcdjmfp 203 4 on on IN cord-006824-btcdjmfp 203 5 the the DT cord-006824-btcdjmfp 203 6 kind kind NN cord-006824-btcdjmfp 203 7 of of IN cord-006824-btcdjmfp 203 8 transplantation transplantation NN cord-006824-btcdjmfp 203 9 , , , cord-006824-btcdjmfp 203 10 intensity intensity NN cord-006824-btcdjmfp 203 11 and and CC cord-006824-btcdjmfp 203 12 mode mode NN cord-006824-btcdjmfp 203 13 of of IN cord-006824-btcdjmfp 203 14 immunosuppression immunosuppression NN cord-006824-btcdjmfp 203 15 , , , cord-006824-btcdjmfp 203 16 EBV EBV NNP cord-006824-btcdjmfp 203 17 - - HYPH cord-006824-btcdjmfp 203 18 status status NN cord-006824-btcdjmfp 203 19 of of IN cord-006824-btcdjmfp 203 20 donor donor NN cord-006824-btcdjmfp 203 21 and and CC cord-006824-btcdjmfp 203 22 recipient recipient NN cord-006824-btcdjmfp 203 23 , , , cord-006824-btcdjmfp 203 24 and and CC cord-006824-btcdjmfp 203 25 bone bone NN cord-006824-btcdjmfp 203 26 marrow marrow NN cord-006824-btcdjmfp 203 27 reconstitution reconstitution NN cord-006824-btcdjmfp 203 28 . . . cord-006824-btcdjmfp 204 1 Although although IN cord-006824-btcdjmfp 204 2 rarely rarely RB cord-006824-btcdjmfp 204 3 confined confine VBN cord-006824-btcdjmfp 204 4 to to IN cord-006824-btcdjmfp 204 5 the the DT cord-006824-btcdjmfp 204 6 lung lung NN cord-006824-btcdjmfp 204 7 , , , cord-006824-btcdjmfp 204 8 the the DT cord-006824-btcdjmfp 204 9 occurrence occurrence NN cord-006824-btcdjmfp 204 10 of of IN cord-006824-btcdjmfp 204 11 this this DT cord-006824-btcdjmfp 204 12 lesion lesion NN cord-006824-btcdjmfp 204 13 together together RB cord-006824-btcdjmfp 204 14 with with IN cord-006824-btcdjmfp 204 15 other other JJ cord-006824-btcdjmfp 204 16 infections infection NNS cord-006824-btcdjmfp 204 17 ( ( -LRB- cord-006824-btcdjmfp 204 18 like like IN cord-006824-btcdjmfp 204 19 aspergillus aspergillus NN cord-006824-btcdjmfp 204 20 ) ) -RRB- cord-006824-btcdjmfp 204 21 or or CC cord-006824-btcdjmfp 204 22 GVHD GVHD NNP cord-006824-btcdjmfp 204 23 makes make VBZ cord-006824-btcdjmfp 204 24 diagnosis diagnosis NN cord-006824-btcdjmfp 204 25 difficult difficult JJ cord-006824-btcdjmfp 204 26 , , , cord-006824-btcdjmfp 204 27 usually usually RB cord-006824-btcdjmfp 204 28 requiring require VBG cord-006824-btcdjmfp 204 29 an an DT cord-006824-btcdjmfp 204 30 invasive invasive JJ cord-006824-btcdjmfp 204 31 approach approach NN cord-006824-btcdjmfp 204 32 . . . cord-006824-btcdjmfp 205 1 The the DT cord-006824-btcdjmfp 205 2 WHO who WP cord-006824-btcdjmfp 205 3 classification classification NN cord-006824-btcdjmfp 205 4 is be VBZ cord-006824-btcdjmfp 205 5 not not RB cord-006824-btcdjmfp 205 6 applied apply VBN cord-006824-btcdjmfp 205 7 uniquely uniquely RB cord-006824-btcdjmfp 205 8 . . . cord-006824-btcdjmfp 206 1 Treatment treatment NN cord-006824-btcdjmfp 206 2 modalities modality NNS cord-006824-btcdjmfp 206 3 range range VBP cord-006824-btcdjmfp 206 4 from from IN cord-006824-btcdjmfp 206 5 lowering lower VBG cord-006824-btcdjmfp 206 6 immunosuppression immunosuppression NN cord-006824-btcdjmfp 206 7 to to IN cord-006824-btcdjmfp 206 8 chemotherapy chemotherapy NN cord-006824-btcdjmfp 206 9 , , , cord-006824-btcdjmfp 206 10 using use VBG cord-006824-btcdjmfp 206 11 anti anti JJ cord-006824-btcdjmfp 206 12 CD CD NNP cord-006824-btcdjmfp 206 13 20 20 CD cord-006824-btcdjmfp 206 14 antibodies antibody NNS cord-006824-btcdjmfp 206 15 to to IN cord-006824-btcdjmfp 206 16 antiviral antiviral JJ cord-006824-btcdjmfp 206 17 therapy therapy NN cord-006824-btcdjmfp 206 18 , , , cord-006824-btcdjmfp 206 19 depending depending NN cord-006824-btcdjmfp 206 20 , , , cord-006824-btcdjmfp 206 21 among among IN cord-006824-btcdjmfp 206 22 other other JJ cord-006824-btcdjmfp 206 23 factors factor NNS cord-006824-btcdjmfp 206 24 , , , cord-006824-btcdjmfp 206 25 on on IN cord-006824-btcdjmfp 206 26 histology histology NN cord-006824-btcdjmfp 206 27 , , , cord-006824-btcdjmfp 206 28 EBV EBV NNP cord-006824-btcdjmfp 206 29 - - HYPH cord-006824-btcdjmfp 206 30 status status NN cord-006824-btcdjmfp 206 31 , , , cord-006824-btcdjmfp 206 32 extent extent NN cord-006824-btcdjmfp 206 33 of of IN cord-006824-btcdjmfp 206 34 the the DT cord-006824-btcdjmfp 206 35 disease disease NN cord-006824-btcdjmfp 206 36 , , , cord-006824-btcdjmfp 206 37 and and CC cord-006824-btcdjmfp 206 38 clinical clinical JJ cord-006824-btcdjmfp 206 39 course course NN cord-006824-btcdjmfp 206 40 . . . cord-006824-btcdjmfp 207 1 Lung lung NN cord-006824-btcdjmfp 207 2 transplantation transplantation NN cord-006824-btcdjmfp 207 3 has have VBZ cord-006824-btcdjmfp 207 4 been be VBN cord-006824-btcdjmfp 207 5 applied apply VBN cord-006824-btcdjmfp 207 6 as as IN cord-006824-btcdjmfp 207 7 ultima ultima NNP cord-006824-btcdjmfp 207 8 ratio ratio NN cord-006824-btcdjmfp 207 9 in in IN cord-006824-btcdjmfp 207 10 patients patient NNS cord-006824-btcdjmfp 207 11 after after IN cord-006824-btcdjmfp 207 12 an an DT cord-006824-btcdjmfp 207 13 interval interval NN cord-006824-btcdjmfp 207 14 of of IN cord-006824-btcdjmfp 207 15 up up IN cord-006824-btcdjmfp 207 16 to to TO cord-006824-btcdjmfp 207 17 14 14 CD cord-006824-btcdjmfp 207 18 years year NNS cord-006824-btcdjmfp 207 19 after after IN cord-006824-btcdjmfp 207 20 HSCT HSCT NNP cord-006824-btcdjmfp 207 21 , , , cord-006824-btcdjmfp 207 22 mostly mostly RB cord-006824-btcdjmfp 207 23 after after IN cord-006824-btcdjmfp 207 24 pulmonary pulmonary JJ cord-006824-btcdjmfp 207 25 complications complication NNS cord-006824-btcdjmfp 207 26 involving involve VBG cord-006824-btcdjmfp 207 27 GVHD GVHD NNP cord-006824-btcdjmfp 207 28 . . . cord-006824-btcdjmfp 208 1 The the DT cord-006824-btcdjmfp 208 2 preferred preferred JJ cord-006824-btcdjmfp 208 3 surgical surgical JJ cord-006824-btcdjmfp 208 4 technique technique NN cord-006824-btcdjmfp 208 5 in in IN cord-006824-btcdjmfp 208 6 most most JJS cord-006824-btcdjmfp 208 7 cases case NNS cord-006824-btcdjmfp 208 8 has have VBZ cord-006824-btcdjmfp 208 9 been be VBN cord-006824-btcdjmfp 208 10 double double JJ cord-006824-btcdjmfp 208 11 lung lung NN cord-006824-btcdjmfp 208 12 transplant transplant NN cord-006824-btcdjmfp 208 13 . . . cord-006824-btcdjmfp 209 1 Reported report VBN cord-006824-btcdjmfp 209 2 survival survival NN cord-006824-btcdjmfp 209 3 is be VBZ cord-006824-btcdjmfp 209 4 similar similar JJ cord-006824-btcdjmfp 209 5 to to IN cord-006824-btcdjmfp 209 6 transplantation transplantation NN cord-006824-btcdjmfp 209 7 for for IN cord-006824-btcdjmfp 209 8 other other JJ cord-006824-btcdjmfp 209 9 causes cause NNS cord-006824-btcdjmfp 210 1 -with -with . cord-006824-btcdjmfp 211 1 one one CD cord-006824-btcdjmfp 211 2 patient patient NN cord-006824-btcdjmfp 211 3 surviving survive VBG cord-006824-btcdjmfp 211 4 more more JJR cord-006824-btcdjmfp 211 5 than than IN cord-006824-btcdjmfp 211 6 seven seven CD cord-006824-btcdjmfp 211 7 years year NNS cord-006824-btcdjmfp 211 8 [ [ -LRB- cord-006824-btcdjmfp 211 9 37 37 CD cord-006824-btcdjmfp 211 10 ] ] -RRB- cord-006824-btcdjmfp 211 11 . . . cord-006824-btcdjmfp 212 1 Out out IN cord-006824-btcdjmfp 212 2 of of IN cord-006824-btcdjmfp 212 3 this this DT cord-006824-btcdjmfp 212 4 series series NN cord-006824-btcdjmfp 212 5 , , , cord-006824-btcdjmfp 212 6 one one CD cord-006824-btcdjmfp 212 7 patient patient NN cord-006824-btcdjmfp 212 8 developed develop VBD cord-006824-btcdjmfp 212 9 BOOP BOOP NNP cord-006824-btcdjmfp 212 10 , , , cord-006824-btcdjmfp 212 11 a a DT cord-006824-btcdjmfp 212 12 condition condition NN cord-006824-btcdjmfp 212 13 rarely rarely RB cord-006824-btcdjmfp 212 14 seen see VBN cord-006824-btcdjmfp 212 15 after after IN cord-006824-btcdjmfp 212 16 lung lung NN cord-006824-btcdjmfp 212 17 transplantation transplantation NN cord-006824-btcdjmfp 212 18 . . . cord-006824-btcdjmfp 213 1 A a DT cord-006824-btcdjmfp 213 2 girl girl NN cord-006824-btcdjmfp 213 3 with with IN cord-006824-btcdjmfp 213 4 a a DT cord-006824-btcdjmfp 213 5 lobar lobar NN cord-006824-btcdjmfp 213 6 transplant transplant NN cord-006824-btcdjmfp 213 7 from from IN cord-006824-btcdjmfp 213 8 the the DT cord-006824-btcdjmfp 213 9 same same JJ cord-006824-btcdjmfp 213 10 living living NN cord-006824-btcdjmfp 213 11 donor donor NN cord-006824-btcdjmfp 213 12 as as IN cord-006824-btcdjmfp 213 13 her -PRON- PRP$ cord-006824-btcdjmfp 213 14 hematopoetic hematopoetic JJ cord-006824-btcdjmfp 213 15 stem stem NN cord-006824-btcdjmfp 213 16 cells cell NNS cord-006824-btcdjmfp 213 17 is be VBZ cord-006824-btcdjmfp 213 18 the the DT cord-006824-btcdjmfp 213 19 only only RB cord-006824-btcdjmfp 213 20 known know VBN cord-006824-btcdjmfp 213 21 person person NN cord-006824-btcdjmfp 213 22 without without IN cord-006824-btcdjmfp 213 23 immunosuppression immunosuppression NN cord-006824-btcdjmfp 213 24 after after IN cord-006824-btcdjmfp 213 25 lung lung NN cord-006824-btcdjmfp 213 26 transplantation transplantation NN cord-006824-btcdjmfp 213 27 [ [ -LRB- cord-006824-btcdjmfp 213 28 73 73 CD cord-006824-btcdjmfp 213 29 ] ] -RRB- cord-006824-btcdjmfp 213 30 . . . cord-006824-btcdjmfp 214 1 Generally generally RB cord-006824-btcdjmfp 214 2 , , , cord-006824-btcdjmfp 214 3 prognosis prognosis NN cord-006824-btcdjmfp 214 4 after after IN cord-006824-btcdjmfp 214 5 lung lung NN cord-006824-btcdjmfp 214 6 transplantation transplantation NN cord-006824-btcdjmfp 214 7 is be VBZ cord-006824-btcdjmfp 214 8 a a DT cord-006824-btcdjmfp 214 9 45 45 CD cord-006824-btcdjmfp 214 10 % % NN cord-006824-btcdjmfp 214 11 survival survival NN cord-006824-btcdjmfp 214 12 rate rate NN cord-006824-btcdjmfp 214 13 after after IN cord-006824-btcdjmfp 214 14 5 5 CD cord-006824-btcdjmfp 214 15 years year NNS cord-006824-btcdjmfp 214 16 . . . cord-006824-btcdjmfp 215 1 Pulmonary pulmonary JJ cord-006824-btcdjmfp 215 2 complications complication NNS cord-006824-btcdjmfp 215 3 after after IN cord-006824-btcdjmfp 215 4 hematopoetic hematopoetic JJ cord-006824-btcdjmfp 215 5 stem stem NN cord-006824-btcdjmfp 215 6 cell cell NN cord-006824-btcdjmfp 215 7 transplantation transplantation NN cord-006824-btcdjmfp 215 8 are be VBP cord-006824-btcdjmfp 215 9 poorly poorly RB cord-006824-btcdjmfp 215 10 understood understand VBN cord-006824-btcdjmfp 215 11 and and CC cord-006824-btcdjmfp 215 12 treatment treatment NN cord-006824-btcdjmfp 215 13 is be VBZ cord-006824-btcdjmfp 215 14 unsatisfactory unsatisfactory JJ cord-006824-btcdjmfp 215 15 . . . cord-006824-btcdjmfp 216 1 There there EX cord-006824-btcdjmfp 216 2 is be VBZ cord-006824-btcdjmfp 216 3 no no DT cord-006824-btcdjmfp 216 4 standardised standardised JJ cord-006824-btcdjmfp 216 5 pulmonary pulmonary JJ cord-006824-btcdjmfp 216 6 follow follow NN cord-006824-btcdjmfp 216 7 - - HYPH cord-006824-btcdjmfp 216 8 up up NN cord-006824-btcdjmfp 216 9 for for IN cord-006824-btcdjmfp 216 10 children child NNS cord-006824-btcdjmfp 216 11 after after IN cord-006824-btcdjmfp 216 12 hematopoetic hematopoetic JJ cord-006824-btcdjmfp 216 13 stem stem NN cord-006824-btcdjmfp 216 14 cell cell NN cord-006824-btcdjmfp 216 15 transplantation transplantation NN cord-006824-btcdjmfp 216 16 with with IN cord-006824-btcdjmfp 216 17 disappointing disappointing JJ cord-006824-btcdjmfp 216 18 rates rate NNS cord-006824-btcdjmfp 216 19 of of IN cord-006824-btcdjmfp 216 20 pulmonary pulmonary JJ cord-006824-btcdjmfp 216 21 function function NN cord-006824-btcdjmfp 216 22 measurements measurement NNS cord-006824-btcdjmfp 216 23 [ [ -LRB- cord-006824-btcdjmfp 216 24 23 23 CD cord-006824-btcdjmfp 216 25 ] ] -RRB- cord-006824-btcdjmfp 216 26 . . . cord-006824-btcdjmfp 217 1 On on IN cord-006824-btcdjmfp 217 2 the the DT cord-006824-btcdjmfp 217 3 other other JJ cord-006824-btcdjmfp 217 4 hand hand NN cord-006824-btcdjmfp 217 5 , , , cord-006824-btcdjmfp 217 6 the the DT cord-006824-btcdjmfp 217 7 spectrum spectrum NN cord-006824-btcdjmfp 217 8 of of IN cord-006824-btcdjmfp 217 9 pulmonary pulmonary JJ cord-006824-btcdjmfp 217 10 complications complication NNS cord-006824-btcdjmfp 217 11 is be VBZ cord-006824-btcdjmfp 217 12 limited limit VBN cord-006824-btcdjmfp 217 13 and and CC cord-006824-btcdjmfp 217 14 the the DT cord-006824-btcdjmfp 217 15 time time NN cord-006824-btcdjmfp 217 16 sequence sequence NN cord-006824-btcdjmfp 217 17 more more RBR cord-006824-btcdjmfp 217 18 or or CC cord-006824-btcdjmfp 217 19 less less RBR cord-006824-btcdjmfp 217 20 known known JJ cord-006824-btcdjmfp 217 21 . . . cord-006824-btcdjmfp 218 1 Diagnostically diagnostically RB cord-006824-btcdjmfp 218 2 it -PRON- PRP cord-006824-btcdjmfp 218 3 would would MD cord-006824-btcdjmfp 218 4 seem seem VB cord-006824-btcdjmfp 218 5 essential essential JJ cord-006824-btcdjmfp 218 6 to to TO cord-006824-btcdjmfp 218 7 follow follow VB cord-006824-btcdjmfp 218 8 a a DT cord-006824-btcdjmfp 218 9 scheduled schedule VBN cord-006824-btcdjmfp 218 10 plan plan NN cord-006824-btcdjmfp 218 11 of of IN cord-006824-btcdjmfp 218 12 pulmonary pulmonary JJ cord-006824-btcdjmfp 218 13 surveillance surveillance NN cord-006824-btcdjmfp 218 14 measures measure NNS cord-006824-btcdjmfp 218 15 including include VBG cord-006824-btcdjmfp 218 16 body body NN cord-006824-btcdjmfp 218 17 plethysmography plethysmography NN cord-006824-btcdjmfp 218 18 , , , cord-006824-btcdjmfp 218 19 assessment assessment NN cord-006824-btcdjmfp 218 20 of of IN cord-006824-btcdjmfp 218 21 gas gas NN cord-006824-btcdjmfp 218 22 exchange exchange NN cord-006824-btcdjmfp 218 23 and and CC cord-006824-btcdjmfp 218 24 exercise exercise NN cord-006824-btcdjmfp 218 25 capacity capacity NN cord-006824-btcdjmfp 218 26 as as RB cord-006824-btcdjmfp 218 27 well well RB cord-006824-btcdjmfp 218 28 as as IN cord-006824-btcdjmfp 218 29 screening screening NN cord-006824-btcdjmfp 218 30 for for IN cord-006824-btcdjmfp 218 31 infections infection NNS cord-006824-btcdjmfp 218 32 . . . cord-006824-btcdjmfp 219 1 This this DT cord-006824-btcdjmfp 219 2 should should MD cord-006824-btcdjmfp 219 3 make make VB cord-006824-btcdjmfp 219 4 it -PRON- PRP cord-006824-btcdjmfp 219 5 possible possible JJ cord-006824-btcdjmfp 219 6 to to TO cord-006824-btcdjmfp 219 7 gain gain VB cord-006824-btcdjmfp 219 8 insight insight NN cord-006824-btcdjmfp 219 9 into into IN cord-006824-btcdjmfp 219 10 the the DT cord-006824-btcdjmfp 219 11 pathogenesis pathogenesis NN cord-006824-btcdjmfp 219 12 of of IN cord-006824-btcdjmfp 219 13 the the DT cord-006824-btcdjmfp 219 14 diseases disease NNS cord-006824-btcdjmfp 219 15 and and CC cord-006824-btcdjmfp 219 16 examine examine VB cord-006824-btcdjmfp 219 17 whether whether IN cord-006824-btcdjmfp 219 18 bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 219 19 obliterans obliteran NNS cord-006824-btcdjmfp 219 20 can can MD cord-006824-btcdjmfp 219 21 be be VB cord-006824-btcdjmfp 219 22 prevented prevent VBN cord-006824-btcdjmfp 219 23 by by IN cord-006824-btcdjmfp 219 24 therapeutical therapeutical JJ cord-006824-btcdjmfp 219 25 measures measure NNS cord-006824-btcdjmfp 219 26 at at IN cord-006824-btcdjmfp 219 27 an an DT cord-006824-btcdjmfp 219 28 early early JJ cord-006824-btcdjmfp 219 29 stage stage NN cord-006824-btcdjmfp 219 30 . . . cord-006824-btcdjmfp 220 1 As as IN cord-006824-btcdjmfp 220 2 therapeutical therapeutical JJ cord-006824-btcdjmfp 220 3 options option NNS cord-006824-btcdjmfp 220 4 are be VBP cord-006824-btcdjmfp 220 5 limited limit VBN cord-006824-btcdjmfp 220 6 in in IN cord-006824-btcdjmfp 220 7 advanced advanced JJ cord-006824-btcdjmfp 220 8 BO BO NNP cord-006824-btcdjmfp 220 9 , , , cord-006824-btcdjmfp 220 10 prophylaxis prophylaxis NN cord-006824-btcdjmfp 220 11 and and CC cord-006824-btcdjmfp 220 12 preemptive preemptive JJ cord-006824-btcdjmfp 220 13 therapy therapy NN cord-006824-btcdjmfp 220 14 may may MD cord-006824-btcdjmfp 220 15 be be VB cord-006824-btcdjmfp 220 16 crucial crucial JJ cord-006824-btcdjmfp 220 17 . . . cord-006824-btcdjmfp 221 1 As as IN cord-006824-btcdjmfp 221 2 a a DT cord-006824-btcdjmfp 221 3 prerequisite prerequisite NN cord-006824-btcdjmfp 221 4 , , , cord-006824-btcdjmfp 221 5 risk risk NN cord-006824-btcdjmfp 221 6 factors factor NNS cord-006824-btcdjmfp 221 7 should should MD cord-006824-btcdjmfp 221 8 be be VB cord-006824-btcdjmfp 221 9 carefully carefully RB cord-006824-btcdjmfp 221 10 studied study VBN cord-006824-btcdjmfp 221 11 and and CC cord-006824-btcdjmfp 221 12 causal causal JJ cord-006824-btcdjmfp 221 13 strategies strategy NNS cord-006824-btcdjmfp 221 14 developed develop VBN cord-006824-btcdjmfp 221 15 in in IN cord-006824-btcdjmfp 221 16 a a DT cord-006824-btcdjmfp 221 17 multicenter multicenter JJ cord-006824-btcdjmfp 221 18 approach approach NN cord-006824-btcdjmfp 221 19 . . . cord-006824-btcdjmfp 222 1 ( ( -LRB- cord-006824-btcdjmfp 222 2 7 7 CD cord-006824-btcdjmfp 222 3 ) ) -RRB- cord-006824-btcdjmfp 222 4 _SP cord-006824-btcdjmfp 223 1 The the DT cord-006824-btcdjmfp 223 2 treatment treatment NN cord-006824-btcdjmfp 223 3 of of IN cord-006824-btcdjmfp 223 4 inborn inborn JJ cord-006824-btcdjmfp 223 5 metabolic metabolic JJ cord-006824-btcdjmfp 223 6 diseases disease NNS cord-006824-btcdjmfp 223 7 such such JJ cord-006824-btcdjmfp 223 8 as as IN cord-006824-btcdjmfp 223 9 lysosomal lysosomal JJ cord-006824-btcdjmfp 223 10 hydrolase hydrolase NN cord-006824-btcdjmfp 223 11 deficiencies deficiency NNS cord-006824-btcdjmfp 223 12 [ [ -LRB- cord-006824-btcdjmfp 223 13 21 21 CD cord-006824-btcdjmfp 223 14 , , , cord-006824-btcdjmfp 223 15 32 32 CD cord-006824-btcdjmfp 223 16 ] ] -RRB- cord-006824-btcdjmfp 223 17 and and CC cord-006824-btcdjmfp 223 18 peroxisomal peroxisomal JJ cord-006824-btcdjmfp 223 19 disorders disorder NNS cord-006824-btcdjmfp 223 20 such such JJ cord-006824-btcdjmfp 223 21 as as IN cord-006824-btcdjmfp 223 22 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 223 23 ( ( -LRB- cord-006824-btcdjmfp 223 24 ALD ALD NNP cord-006824-btcdjmfp 223 25 ) ) -RRB- cord-006824-btcdjmfp 223 26 [ [ -LRB- cord-006824-btcdjmfp 223 27 1 1 CD cord-006824-btcdjmfp 223 28 , , , cord-006824-btcdjmfp 223 29 28 28 CD cord-006824-btcdjmfp 223 30 ] ] -RRB- cord-006824-btcdjmfp 223 31 has have VBZ cord-006824-btcdjmfp 223 32 been be VBN cord-006824-btcdjmfp 223 33 limited limit VBN cord-006824-btcdjmfp 223 34 to to IN cord-006824-btcdjmfp 223 35 symptomatic symptomatic JJ cord-006824-btcdjmfp 223 36 supportive supportive JJ cord-006824-btcdjmfp 223 37 care care NN cord-006824-btcdjmfp 223 38 . . . cord-006824-btcdjmfp 224 1 Intravenous intravenous JJ cord-006824-btcdjmfp 224 2 enzyme enzyme NN cord-006824-btcdjmfp 224 3 replacement replacement NN cord-006824-btcdjmfp 224 4 has have VBZ cord-006824-btcdjmfp 224 5 been be VBN cord-006824-btcdjmfp 224 6 largely largely RB cord-006824-btcdjmfp 224 7 ineffective ineffective JJ cord-006824-btcdjmfp 224 8 , , , cord-006824-btcdjmfp 224 9 especially especially RB cord-006824-btcdjmfp 224 10 in in IN cord-006824-btcdjmfp 224 11 storage storage NN cord-006824-btcdjmfp 224 12 diseases disease NNS cord-006824-btcdjmfp 224 13 with with IN cord-006824-btcdjmfp 224 14 central central JJ cord-006824-btcdjmfp 224 15 nervous nervous JJ cord-006824-btcdjmfp 224 16 system system NN cord-006824-btcdjmfp 224 17 ( ( -LRB- cord-006824-btcdjmfp 224 18 CNS CNS NNP cord-006824-btcdjmfp 224 19 ) ) -RRB- cord-006824-btcdjmfp 224 20 manifestations manifestation NNS cord-006824-btcdjmfp 224 21 . . . cord-006824-btcdjmfp 225 1 Allogeneic allogeneic IN cord-006824-btcdjmfp 225 2 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 225 3 cell cell NN cord-006824-btcdjmfp 225 4 transplantation transplantation NN cord-006824-btcdjmfp 225 5 ( ( -LRB- cord-006824-btcdjmfp 225 6 HCT HCT NNP cord-006824-btcdjmfp 225 7 ) ) -RRB- cord-006824-btcdjmfp 225 8 with with IN cord-006824-btcdjmfp 225 9 related related JJ cord-006824-btcdjmfp 225 10 or or CC cord-006824-btcdjmfp 225 11 unrelated unrelated JJ cord-006824-btcdjmfp 225 12 bone bone NN cord-006824-btcdjmfp 225 13 marrow marrow NN cord-006824-btcdjmfp 225 14 cells cell NNS cord-006824-btcdjmfp 225 15 , , , cord-006824-btcdjmfp 225 16 peripheral peripheral JJ cord-006824-btcdjmfp 225 17 blood blood NN cord-006824-btcdjmfp 225 18 progenitor progenitor NN cord-006824-btcdjmfp 225 19 cells cell NNS cord-006824-btcdjmfp 225 20 , , , cord-006824-btcdjmfp 225 21 or or CC cord-006824-btcdjmfp 226 1 placental placental JJ cord-006824-btcdjmfp 226 2 ( ( -LRB- cord-006824-btcdjmfp 226 3 umbilical umbilical JJ cord-006824-btcdjmfp 226 4 cord cord NN cord-006824-btcdjmfp 226 5 ) ) -RRB- cord-006824-btcdjmfp 226 6 blood blood NN cord-006824-btcdjmfp 226 7 cells cell NNS cord-006824-btcdjmfp 226 8 in in IN cord-006824-btcdjmfp 226 9 these these DT cord-006824-btcdjmfp 226 10 conditions condition NNS cord-006824-btcdjmfp 226 11 repopulates repopulate VBZ cord-006824-btcdjmfp 226 12 recipient recipient NN cord-006824-btcdjmfp 226 13 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 226 14 and and CC cord-006824-btcdjmfp 226 15 lymphoid lymphoid JJ cord-006824-btcdjmfp 226 16 cells cell NNS cord-006824-btcdjmfp 226 17 with with IN cord-006824-btcdjmfp 226 18 metabolically metabolically RB cord-006824-btcdjmfp 226 19 normal normal JJ cord-006824-btcdjmfp 226 20 donor donor NN cord-006824-btcdjmfp 226 21 - - HYPH cord-006824-btcdjmfp 226 22 derived derive VBN cord-006824-btcdjmfp 226 23 cells cell NNS cord-006824-btcdjmfp 226 24 and and CC cord-006824-btcdjmfp 226 25 thus thus RB cord-006824-btcdjmfp 226 26 provides provide VBZ cord-006824-btcdjmfp 226 27 a a DT cord-006824-btcdjmfp 226 28 self self NN cord-006824-btcdjmfp 226 29 - - HYPH cord-006824-btcdjmfp 226 30 renewing renew VBG cord-006824-btcdjmfp 226 31 source source NN cord-006824-btcdjmfp 226 32 of of IN cord-006824-btcdjmfp 226 33 hydrolase hydrolase NN cord-006824-btcdjmfp 226 34 . . . cord-006824-btcdjmfp 227 1 In in IN cord-006824-btcdjmfp 227 2 addition addition NN cord-006824-btcdjmfp 227 3 , , , cord-006824-btcdjmfp 227 4 HCT HCT NNP cord-006824-btcdjmfp 227 5 effectively effectively RB cord-006824-btcdjmfp 227 6 repopulates repopulate VBZ cord-006824-btcdjmfp 227 7 mononuclear mononuclear JJ cord-006824-btcdjmfp 227 8 phagocytic phagocytic JJ cord-006824-btcdjmfp 227 9 cells cell NNS cord-006824-btcdjmfp 227 10 , , , cord-006824-btcdjmfp 227 11 including include VBG cord-006824-btcdjmfp 227 12 macrophages macrophage NNS cord-006824-btcdjmfp 227 13 , , , cord-006824-btcdjmfp 227 14 hepatic hepatic JJ cord-006824-btcdjmfp 227 15 Kupffer Kupffer NNP cord-006824-btcdjmfp 227 16 cells cell NNS cord-006824-btcdjmfp 227 17 , , , cord-006824-btcdjmfp 227 18 and and CC cord-006824-btcdjmfp 227 19 pulmonary pulmonary JJ cord-006824-btcdjmfp 227 20 alveolar alveolar NN cord-006824-btcdjmfp 227 21 macrophages macrophage NNS cord-006824-btcdjmfp 227 22 , , , cord-006824-btcdjmfp 227 23 in in IN cord-006824-btcdjmfp 227 24 which which WDT cord-006824-btcdjmfp 227 25 substrate substrate NN cord-006824-btcdjmfp 227 26 often often RB cord-006824-btcdjmfp 227 27 accumulates accumulate VBZ cord-006824-btcdjmfp 227 28 in in IN cord-006824-btcdjmfp 227 29 storage storage NN cord-006824-btcdjmfp 227 30 diseases disease NNS cord-006824-btcdjmfp 227 31 . . . cord-006824-btcdjmfp 228 1 As as IN cord-006824-btcdjmfp 228 2 discussed discuss VBN cord-006824-btcdjmfp 228 3 below below RB cord-006824-btcdjmfp 228 4 , , , cord-006824-btcdjmfp 228 5 the the DT cord-006824-btcdjmfp 228 6 repopulation repopulation NN cord-006824-btcdjmfp 228 7 of of IN cord-006824-btcdjmfp 228 8 microglia microglia NN cord-006824-btcdjmfp 228 9 with with IN cord-006824-btcdjmfp 228 10 donor donor NN cord-006824-btcdjmfp 228 11 - - HYPH cord-006824-btcdjmfp 228 12 derived derive VBN cord-006824-btcdjmfp 228 13 cells cell NNS cord-006824-btcdjmfp 228 14 after after IN cord-006824-btcdjmfp 228 15 allogeneic allogeneic NN cord-006824-btcdjmfp 228 16 HCT hct NN cord-006824-btcdjmfp 228 17 is be VBZ cord-006824-btcdjmfp 228 18 a a DT cord-006824-btcdjmfp 228 19 potentially potentially RB cord-006824-btcdjmfp 228 20 important important JJ cord-006824-btcdjmfp 228 21 therapeutic therapeutic JJ cord-006824-btcdjmfp 228 22 mechanism mechanism NN cord-006824-btcdjmfp 228 23 of of IN cord-006824-btcdjmfp 228 24 allogeneic allogeneic NN cord-006824-btcdjmfp 228 25 HCT hct NN cord-006824-btcdjmfp 228 26 in in IN cord-006824-btcdjmfp 228 27 patients patient NNS cord-006824-btcdjmfp 228 28 with with IN cord-006824-btcdjmfp 228 29 CNS CNS NNP cord-006824-btcdjmfp 228 30 manifestations manifestation NNS cord-006824-btcdjmfp 228 31 of of IN cord-006824-btcdjmfp 228 32 metabolic metabolic JJ cord-006824-btcdjmfp 228 33 diseases disease NNS cord-006824-btcdjmfp 228 34 . . . cord-006824-btcdjmfp 229 1 Intercellular intercellular JJ cord-006824-btcdjmfp 229 2 transport transport NN cord-006824-btcdjmfp 229 3 of of IN cord-006824-btcdjmfp 229 4 lysosomal lysosomal JJ cord-006824-btcdjmfp 229 5 hydrolase hydrolase NN cord-006824-btcdjmfp 229 6 from from IN cord-006824-btcdjmfp 229 7 normal normal JJ cord-006824-btcdjmfp 229 8 donor donor NN cord-006824-btcdjmfp 229 9 cells cell NNS cord-006824-btcdjmfp 229 10 occurs occur VBZ cord-006824-btcdjmfp 229 11 by by IN cord-006824-btcdjmfp 229 12 both both DT cord-006824-btcdjmfp 229 13 receptor receptor NN cord-006824-btcdjmfp 229 14 - - HYPH cord-006824-btcdjmfp 229 15 mediated mediate VBN cord-006824-btcdjmfp 229 16 endocytosis endocytosis NN cord-006824-btcdjmfp 229 17 and and CC cord-006824-btcdjmfp 229 18 direct direct JJ cord-006824-btcdjmfp 229 19 transfer transfer NN cord-006824-btcdjmfp 229 20 of of IN cord-006824-btcdjmfp 229 21 enzyme enzyme NN cord-006824-btcdjmfp 229 22 from from IN cord-006824-btcdjmfp 229 23 adjacent adjacent JJ cord-006824-btcdjmfp 229 24 cells cell NNS cord-006824-btcdjmfp 229 25 [ [ -LRB- cord-006824-btcdjmfp 229 26 2 2 CD cord-006824-btcdjmfp 229 27 ] ] -RRB- cord-006824-btcdjmfp 229 28 . . . cord-006824-btcdjmfp 230 1 The the DT cord-006824-btcdjmfp 230 2 heterogeneity heterogeneity NN cord-006824-btcdjmfp 230 3 of of IN cord-006824-btcdjmfp 230 4 receptor receptor NN cord-006824-btcdjmfp 230 5 - - HYPH cord-006824-btcdjmfp 230 6 mediated mediate VBN cord-006824-btcdjmfp 230 7 endocytosis endocytosis NN cord-006824-btcdjmfp 230 8 systems system NNS cord-006824-btcdjmfp 230 9 limits limit VBZ cord-006824-btcdjmfp 230 10 the the DT cord-006824-btcdjmfp 230 11 extent extent NN cord-006824-btcdjmfp 230 12 of of IN cord-006824-btcdjmfp 230 13 hydrolase hydrolase NN cord-006824-btcdjmfp 230 14 uptake uptake NN cord-006824-btcdjmfp 230 15 among among IN cord-006824-btcdjmfp 230 16 various various JJ cord-006824-btcdjmfp 230 17 cell cell NN cord-006824-btcdjmfp 230 18 types type NNS cord-006824-btcdjmfp 230 19 and and CC cord-006824-btcdjmfp 230 20 tissues tissue NNS cord-006824-btcdjmfp 230 21 [ [ -LRB- cord-006824-btcdjmfp 230 22 38 38 CD cord-006824-btcdjmfp 230 23 , , , cord-006824-btcdjmfp 230 24 40 40 CD cord-006824-btcdjmfp 230 25 ] ] -RRB- cord-006824-btcdjmfp 230 26 . . . cord-006824-btcdjmfp 231 1 Direct direct JJ cord-006824-btcdjmfp 231 2 intercellular intercellular JJ cord-006824-btcdjmfp 231 3 transfer transfer NN cord-006824-btcdjmfp 231 4 of of IN cord-006824-btcdjmfp 231 5 hydrolase hydrolase NN cord-006824-btcdjmfp 231 6 occurs occur VBZ cord-006824-btcdjmfp 231 7 independent independent JJ cord-006824-btcdjmfp 231 8 of of IN cord-006824-btcdjmfp 231 9 specific specific JJ cord-006824-btcdjmfp 231 10 receptors receptor NNS cord-006824-btcdjmfp 231 11 but but CC cord-006824-btcdjmfp 231 12 requires require VBZ cord-006824-btcdjmfp 231 13 cell cell NN cord-006824-btcdjmfp 231 14 - - HYPH cord-006824-btcdjmfp 231 15 to to IN cord-006824-btcdjmfp 231 16 - - HYPH cord-006824-btcdjmfp 231 17 cell cell NN cord-006824-btcdjmfp 231 18 contact contact NN cord-006824-btcdjmfp 231 19 and and CC cord-006824-btcdjmfp 231 20 participation participation NN cord-006824-btcdjmfp 231 21 of of IN cord-006824-btcdjmfp 231 22 adhesion adhesion NN cord-006824-btcdjmfp 231 23 molecules molecule NNS cord-006824-btcdjmfp 231 24 such such JJ cord-006824-btcdjmfp 231 25 as as IN cord-006824-btcdjmfp 231 26 LFA-1 LFA-1 NNP cord-006824-btcdjmfp 231 27 and and CC cord-006824-btcdjmfp 231 28 -3 -3 NNP cord-006824-btcdjmfp 231 29 , , , cord-006824-btcdjmfp 231 30 ICAM-1 ICAM-1 NNP cord-006824-btcdjmfp 231 31 , , , cord-006824-btcdjmfp 231 32 -2 -2 NNP cord-006824-btcdjmfp 231 33 , , , cord-006824-btcdjmfp 231 34 and and CC cord-006824-btcdjmfp 231 35 -3 -3 NNP cord-006824-btcdjmfp 231 36 , , , cord-006824-btcdjmfp 231 37 and and CC cord-006824-btcdjmfp 231 38 CD2 CD2 NNP cord-006824-btcdjmfp 231 39 ( ( -LRB- cord-006824-btcdjmfp 231 40 the the DT cord-006824-btcdjmfp 231 41 sheep sheep NN cord-006824-btcdjmfp 231 42 erythrocyte erythrocyte NN cord-006824-btcdjmfp 231 43 receptor receptor NN cord-006824-btcdjmfp 231 44 on on IN cord-006824-btcdjmfp 231 45 T t NN cord-006824-btcdjmfp 231 46 lymphocytes lymphocyte NNS cord-006824-btcdjmfp 231 47 ) ) -RRB- cord-006824-btcdjmfp 231 48 [ [ -LRB- cord-006824-btcdjmfp 231 49 2 2 CD cord-006824-btcdjmfp 231 50 , , , cord-006824-btcdjmfp 231 51 34 34 CD cord-006824-btcdjmfp 231 52 ] ] -RRB- cord-006824-btcdjmfp 231 53 . . . cord-006824-btcdjmfp 232 1 Unlike unlike IN cord-006824-btcdjmfp 232 2 lysosomal lysosomal JJ cord-006824-btcdjmfp 232 3 storage storage NN cord-006824-btcdjmfp 232 4 diseases disease NNS cord-006824-btcdjmfp 232 5 , , , cord-006824-btcdjmfp 232 6 ALD ALD NNP cord-006824-btcdjmfp 232 7 is be VBZ cord-006824-btcdjmfp 232 8 due due JJ cord-006824-btcdjmfp 232 9 to to IN cord-006824-btcdjmfp 232 10 a a DT cord-006824-btcdjmfp 232 11 defective defective JJ cord-006824-btcdjmfp 232 12 protein protein NN cord-006824-btcdjmfp 232 13 component component NN cord-006824-btcdjmfp 232 14 of of IN cord-006824-btcdjmfp 232 15 the the DT cord-006824-btcdjmfp 232 16 peroxisomal peroxisomal JJ cord-006824-btcdjmfp 232 17 membrane membrane NN cord-006824-btcdjmfp 232 18 that that WDT cord-006824-btcdjmfp 232 19 is be VBZ cord-006824-btcdjmfp 232 20 neither neither CC cord-006824-btcdjmfp 232 21 secreted secrete VBN cord-006824-btcdjmfp 232 22 from from IN cord-006824-btcdjmfp 232 23 normal normal JJ cord-006824-btcdjmfp 232 24 cells cell NNS cord-006824-btcdjmfp 232 25 nor nor CC cord-006824-btcdjmfp 232 26 transferred transfer VBN cord-006824-btcdjmfp 232 27 between between IN cord-006824-btcdjmfp 232 28 cells cell NNS cord-006824-btcdjmfp 232 29 , , , cord-006824-btcdjmfp 232 30 leading lead VBG cord-006824-btcdjmfp 232 31 to to IN cord-006824-btcdjmfp 232 32 defective defective JJ cord-006824-btcdjmfp 232 33 oxidation oxidation NN cord-006824-btcdjmfp 232 34 and and CC cord-006824-btcdjmfp 232 35 elevated elevated JJ cord-006824-btcdjmfp 232 36 plasma plasma NN cord-006824-btcdjmfp 232 37 levels level NNS cord-006824-btcdjmfp 232 38 of of IN cord-006824-btcdjmfp 232 39 very very RB cord-006824-btcdjmfp 232 40 long long JJ cord-006824-btcdjmfp 232 41 chain chain NN cord-006824-btcdjmfp 232 42 fatty fatty JJ cord-006824-btcdjmfp 232 43 acids acid NNS cord-006824-btcdjmfp 232 44 ( ( -LRB- cord-006824-btcdjmfp 232 45 VLCFAs VLCFAs NNP cord-006824-btcdjmfp 232 46 ) ) -RRB- cord-006824-btcdjmfp 232 47 [ [ -LRB- cord-006824-btcdjmfp 232 48 30 30 CD cord-006824-btcdjmfp 232 49 ] ] -RRB- cord-006824-btcdjmfp 232 50 . . . cord-006824-btcdjmfp 233 1 Co co NN cord-006824-btcdjmfp 233 2 - - NN cord-006824-btcdjmfp 233 3 culture culture NN cord-006824-btcdjmfp 233 4 with with IN cord-006824-btcdjmfp 233 5 normal normal JJ cord-006824-btcdjmfp 233 6 cells cell NNS cord-006824-btcdjmfp 233 7 does do VBZ cord-006824-btcdjmfp 233 8 not not RB cord-006824-btcdjmfp 233 9 improve improve VB cord-006824-btcdjmfp 233 10 VLCFA VLCFA NNP cord-006824-btcdjmfp 233 11 oxidation oxidation NN cord-006824-btcdjmfp 233 12 by by IN cord-006824-btcdjmfp 233 13 ALD ALD NNP cord-006824-btcdjmfp 233 14 fibroblasts fibroblast NNS cord-006824-btcdjmfp 233 15 , , , cord-006824-btcdjmfp 233 16 indicating indicate VBG cord-006824-btcdjmfp 233 17 that that IN cord-006824-btcdjmfp 233 18 improvement improvement NN cord-006824-btcdjmfp 233 19 of of IN cord-006824-btcdjmfp 233 20 ALD ALD NNP cord-006824-btcdjmfp 233 21 after after IN cord-006824-btcdjmfp 233 22 HCT HCT NNP cord-006824-btcdjmfp 233 23 is be VBZ cord-006824-btcdjmfp 233 24 likely likely JJ cord-006824-btcdjmfp 233 25 due due IN cord-006824-btcdjmfp 233 26 to to IN cord-006824-btcdjmfp 233 27 repopulation repopulation NN cord-006824-btcdjmfp 233 28 by by IN cord-006824-btcdjmfp 233 29 metabolically metabolically RB cord-006824-btcdjmfp 233 30 normal normal JJ cord-006824-btcdjmfp 233 31 cells cell NNS cord-006824-btcdjmfp 233 32 instead instead RB cord-006824-btcdjmfp 233 33 of of IN cord-006824-btcdjmfp 233 34 intracellular intracellular JJ cord-006824-btcdjmfp 233 35 transfer transfer NN cord-006824-btcdjmfp 233 36 of of IN cord-006824-btcdjmfp 233 37 molecules molecule NNS cord-006824-btcdjmfp 233 38 from from IN cord-006824-btcdjmfp 233 39 donor donor NN cord-006824-btcdjmfp 233 40 cells cell NNS cord-006824-btcdjmfp 233 41 . . . cord-006824-btcdjmfp 234 1 Other other JJ cord-006824-btcdjmfp 234 2 beneficial beneficial JJ cord-006824-btcdjmfp 234 3 effects effect NNS cord-006824-btcdjmfp 234 4 of of IN cord-006824-btcdjmfp 234 5 allogeneic allogeneic NN cord-006824-btcdjmfp 234 6 HCT hct NN cord-006824-btcdjmfp 234 7 in in IN cord-006824-btcdjmfp 234 8 ALD ALD NNP cord-006824-btcdjmfp 234 9 include include VBP cord-006824-btcdjmfp 234 10 normalization normalization NN cord-006824-btcdjmfp 234 11 of of IN cord-006824-btcdjmfp 234 12 plasma plasma NN cord-006824-btcdjmfp 234 13 VLCFA VLCFA NNP cord-006824-btcdjmfp 234 14 levels level NNS cord-006824-btcdjmfp 234 15 and and CC cord-006824-btcdjmfp 234 16 decreased decrease VBD cord-006824-btcdjmfp 234 17 perivascular perivascular JJ cord-006824-btcdjmfp 234 18 inflammation inflammation NN cord-006824-btcdjmfp 234 19 . . . cord-006824-btcdjmfp 235 1 Microglia Microglia NNP cord-006824-btcdjmfp 235 2 are be VBP cord-006824-btcdjmfp 235 3 the the DT cord-006824-btcdjmfp 235 4 mononuclear mononuclear JJ cord-006824-btcdjmfp 235 5 phagocytic phagocytic JJ cord-006824-btcdjmfp 235 6 cells cell NNS cord-006824-btcdjmfp 235 7 in in IN cord-006824-btcdjmfp 235 8 the the DT cord-006824-btcdjmfp 235 9 CNS CNS NNP cord-006824-btcdjmfp 235 10 [ [ -LRB- cord-006824-btcdjmfp 235 11 11 11 CD cord-006824-btcdjmfp 235 12 , , , cord-006824-btcdjmfp 235 13 24 24 CD cord-006824-btcdjmfp 235 14 ] ] -RRB- cord-006824-btcdjmfp 235 15 and and CC cord-006824-btcdjmfp 235 16 account account VBP cord-006824-btcdjmfp 235 17 for for IN cord-006824-btcdjmfp 235 18 approximately approximately RB cord-006824-btcdjmfp 235 19 5 5 CD cord-006824-btcdjmfp 235 20 % % NN cord-006824-btcdjmfp 235 21 to to TO cord-006824-btcdjmfp 235 22 10 10 CD cord-006824-btcdjmfp 235 23 % % NN cord-006824-btcdjmfp 235 24 of of IN cord-006824-btcdjmfp 235 25 non non JJ cord-006824-btcdjmfp 235 26 - - JJ cord-006824-btcdjmfp 235 27 neuronal neuronal JJ cord-006824-btcdjmfp 235 28 cells cell NNS cord-006824-btcdjmfp 235 29 in in IN cord-006824-btcdjmfp 235 30 the the DT cord-006824-btcdjmfp 235 31 brain brain NN cord-006824-btcdjmfp 235 32 . . . cord-006824-btcdjmfp 236 1 Activated activate VBN cord-006824-btcdjmfp 236 2 microglia microglia NNS cord-006824-btcdjmfp 236 3 , , , cord-006824-btcdjmfp 236 4 also also RB cord-006824-btcdjmfp 236 5 referred refer VBD cord-006824-btcdjmfp 236 6 to to IN cord-006824-btcdjmfp 236 7 as as IN cord-006824-btcdjmfp 236 8 CNS CNS NNP cord-006824-btcdjmfp 236 9 macrophages macrophage NNS cord-006824-btcdjmfp 236 10 , , , cord-006824-btcdjmfp 236 11 are be VBP cord-006824-btcdjmfp 236 12 involved involve VBN cord-006824-btcdjmfp 236 13 in in IN cord-006824-btcdjmfp 236 14 antigen antigen NN cord-006824-btcdjmfp 236 15 presentation presentation NN cord-006824-btcdjmfp 236 16 and and CC cord-006824-btcdjmfp 236 17 responses response NNS cord-006824-btcdjmfp 236 18 to to IN cord-006824-btcdjmfp 236 19 inflammation inflammation NN cord-006824-btcdjmfp 236 20 , , , cord-006824-btcdjmfp 236 21 infection infection NN cord-006824-btcdjmfp 236 22 , , , cord-006824-btcdjmfp 236 23 or or CC cord-006824-btcdjmfp 236 24 CNS CNS NNP cord-006824-btcdjmfp 236 25 injury injury NN cord-006824-btcdjmfp 236 26 [ [ -LRB- cord-006824-btcdjmfp 236 27 11 11 CD cord-006824-btcdjmfp 236 28 ] ] -RRB- cord-006824-btcdjmfp 236 29 . . . cord-006824-btcdjmfp 237 1 Microglia Microglia NNP cord-006824-btcdjmfp 237 2 are be VBP cord-006824-btcdjmfp 237 3 derived derive VBN cord-006824-btcdjmfp 237 4 from from IN cord-006824-btcdjmfp 237 5 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 237 6 precursors precursor NNS cord-006824-btcdjmfp 237 7 that that WDT cord-006824-btcdjmfp 237 8 normally normally RB cord-006824-btcdjmfp 237 9 enter enter VBP cord-006824-btcdjmfp 237 10 the the DT cord-006824-btcdjmfp 237 11 brain brain NN cord-006824-btcdjmfp 237 12 from from IN cord-006824-btcdjmfp 237 13 the the DT cord-006824-btcdjmfp 237 14 peripheral peripheral JJ cord-006824-btcdjmfp 237 15 circulation circulation NN cord-006824-btcdjmfp 237 16 during during IN cord-006824-btcdjmfp 237 17 embryonic embryonic JJ cord-006824-btcdjmfp 237 18 and and CC cord-006824-btcdjmfp 237 19 early early JJ cord-006824-btcdjmfp 237 20 postnatal postnatal JJ cord-006824-btcdjmfp 237 21 life life NN cord-006824-btcdjmfp 237 22 but but CC cord-006824-btcdjmfp 237 23 not not RB cord-006824-btcdjmfp 237 24 in in IN cord-006824-btcdjmfp 237 25 adulthood adulthood NN cord-006824-btcdjmfp 237 26 [ [ -LRB- cord-006824-btcdjmfp 237 27 35 35 CD cord-006824-btcdjmfp 237 28 ] ] -RRB- cord-006824-btcdjmfp 237 29 . . . cord-006824-btcdjmfp 238 1 In in IN cord-006824-btcdjmfp 238 2 rodent rodent NN cord-006824-btcdjmfp 238 3 HCT hct NN cord-006824-btcdjmfp 238 4 recipients recipient NNS cord-006824-btcdjmfp 238 5 , , , cord-006824-btcdjmfp 238 6 donor donor NN cord-006824-btcdjmfp 238 7 - - HYPH cord-006824-btcdjmfp 238 8 derived derive VBN cord-006824-btcdjmfp 238 9 cells cell NNS cord-006824-btcdjmfp 238 10 can can MD cord-006824-btcdjmfp 238 11 be be VB cord-006824-btcdjmfp 238 12 identified identify VBN cord-006824-btcdjmfp 238 13 throughout throughout IN cord-006824-btcdjmfp 238 14 the the DT cord-006824-btcdjmfp 238 15 CNS CNS NNP cord-006824-btcdjmfp 238 16 [ [ -LRB- cord-006824-btcdjmfp 238 17 12 12 CD cord-006824-btcdjmfp 238 18 ] ] -RRB- cord-006824-btcdjmfp 238 19 and and CC cord-006824-btcdjmfp 238 20 over over IN cord-006824-btcdjmfp 238 21 time time NN cord-006824-btcdjmfp 238 22 completely completely RB cord-006824-btcdjmfp 238 23 repopulate repopulate VBP cord-006824-btcdjmfp 238 24 the the DT cord-006824-btcdjmfp 238 25 microglial microglial JJ cord-006824-btcdjmfp 238 26 compartment compartment NNP cord-006824-btcdjmfp 238 27 [ [ -LRB- cord-006824-btcdjmfp 238 28 18 18 CD cord-006824-btcdjmfp 238 29 , , , cord-006824-btcdjmfp 238 30 22 22 CD cord-006824-btcdjmfp 238 31 , , , cord-006824-btcdjmfp 238 32 59 59 CD cord-006824-btcdjmfp 238 33 ] ] -RRB- cord-006824-btcdjmfp 238 34 . . . cord-006824-btcdjmfp 239 1 In in IN cord-006824-btcdjmfp 239 2 feline feline JJ cord-006824-btcdjmfp 239 3 β β NN cord-006824-btcdjmfp 239 4 - - HYPH cord-006824-btcdjmfp 239 5 mannosidosis mannosidosis NNP cord-006824-btcdjmfp 239 6 , , , cord-006824-btcdjmfp 239 7 these these DT cord-006824-btcdjmfp 239 8 donor donor NN cord-006824-btcdjmfp 239 9 cells cell NNS cord-006824-btcdjmfp 239 10 effectively effectively RB cord-006824-btcdjmfp 239 11 transfer transfer VBP cord-006824-btcdjmfp 239 12 lysosomal lysosomal JJ cord-006824-btcdjmfp 239 13 hydrolase hydrolase NN cord-006824-btcdjmfp 239 14 to to IN cord-006824-btcdjmfp 239 15 recipient recipient NN cord-006824-btcdjmfp 239 16 neurons neuron NNS cord-006824-btcdjmfp 239 17 in in IN cord-006824-btcdjmfp 239 18 vivo vivo NNP cord-006824-btcdjmfp 239 19 [ [ -LRB- cord-006824-btcdjmfp 239 20 52 52 CD cord-006824-btcdjmfp 239 21 ] ] -RRB- cord-006824-btcdjmfp 239 22 . . . cord-006824-btcdjmfp 240 1 After after IN cord-006824-btcdjmfp 240 2 HCT hct NN cord-006824-btcdjmfp 240 3 , , , cord-006824-btcdjmfp 240 4 donor donor NN cord-006824-btcdjmfp 240 5 - - HYPH cord-006824-btcdjmfp 240 6 derived derive VBN cord-006824-btcdjmfp 240 7 cells cell NNS cord-006824-btcdjmfp 240 8 also also RB cord-006824-btcdjmfp 240 9 differentiate differentiate VBP cord-006824-btcdjmfp 240 10 into into IN cord-006824-btcdjmfp 240 11 other other JJ cord-006824-btcdjmfp 240 12 non non JJ cord-006824-btcdjmfp 240 13 - - JJ cord-006824-btcdjmfp 240 14 neuronal neuronal JJ cord-006824-btcdjmfp 240 15 CNS cns NN cord-006824-btcdjmfp 240 16 cell cell NN cord-006824-btcdjmfp 240 17 populations population NNS cord-006824-btcdjmfp 240 18 such such JJ cord-006824-btcdjmfp 240 19 as as IN cord-006824-btcdjmfp 240 20 astrocytes astrocyte NNS cord-006824-btcdjmfp 240 21 ( ( -LRB- cord-006824-btcdjmfp 240 22 also also RB cord-006824-btcdjmfp 240 23 referred refer VBN cord-006824-btcdjmfp 240 24 to to IN cord-006824-btcdjmfp 240 25 as as IN cord-006824-btcdjmfp 240 26 macroglia macroglia NNP cord-006824-btcdjmfp 240 27 ) ) -RRB- cord-006824-btcdjmfp 240 28 [ [ -LRB- cord-006824-btcdjmfp 240 29 5 5 CD cord-006824-btcdjmfp 240 30 , , , cord-006824-btcdjmfp 240 31 31 31 CD cord-006824-btcdjmfp 240 32 ] ] -RRB- cord-006824-btcdjmfp 240 33 . . . cord-006824-btcdjmfp 241 1 Postmortem Postmortem NNP cord-006824-btcdjmfp 241 2 studies study NNS cord-006824-btcdjmfp 241 3 confirm confirm VBP cord-006824-btcdjmfp 241 4 that that IN cord-006824-btcdjmfp 241 5 donor donor NN cord-006824-btcdjmfp 241 6 mononuclear mononuclear NN cord-006824-btcdjmfp 241 7 cells cell NNS cord-006824-btcdjmfp 241 8 are be VBP cord-006824-btcdjmfp 241 9 also also RB cord-006824-btcdjmfp 241 10 present present JJ cord-006824-btcdjmfp 241 11 throughout throughout IN cord-006824-btcdjmfp 241 12 the the DT cord-006824-btcdjmfp 241 13 brains brain NNS cord-006824-btcdjmfp 241 14 of of IN cord-006824-btcdjmfp 241 15 human human NN cord-006824-btcdjmfp 241 16 allogeneic allogeneic NN cord-006824-btcdjmfp 241 17 HCT HCT NNP cord-006824-btcdjmfp 241 18 recipients recipient NNS cord-006824-btcdjmfp 241 19 [ [ -LRB- cord-006824-btcdjmfp 241 20 51 51 CD cord-006824-btcdjmfp 241 21 ] ] -RRB- cord-006824-btcdjmfp 241 22 . . . cord-006824-btcdjmfp 242 1 The the DT cord-006824-btcdjmfp 242 2 kinetics kinetic NNS cord-006824-btcdjmfp 242 3 of of IN cord-006824-btcdjmfp 242 4 repopulation repopulation NN cord-006824-btcdjmfp 242 5 of of IN cord-006824-btcdjmfp 242 6 microglia microglia NN cord-006824-btcdjmfp 242 7 after after IN cord-006824-btcdjmfp 242 8 HCT HCT NNP cord-006824-btcdjmfp 242 9 is be VBZ cord-006824-btcdjmfp 242 10 slower slow JJR cord-006824-btcdjmfp 242 11 than than IN cord-006824-btcdjmfp 242 12 that that DT cord-006824-btcdjmfp 242 13 observed observe VBN cord-006824-btcdjmfp 242 14 with with IN cord-006824-btcdjmfp 242 15 other other JJ cord-006824-btcdjmfp 242 16 mononuclear mononuclear JJ cord-006824-btcdjmfp 242 17 phagocytes phagocyte NNS cord-006824-btcdjmfp 242 18 like like IN cord-006824-btcdjmfp 242 19 pulmonary pulmonary JJ cord-006824-btcdjmfp 242 20 alveolar alveolar NN cord-006824-btcdjmfp 242 21 macrophages macrophage NNS cord-006824-btcdjmfp 242 22 and and CC cord-006824-btcdjmfp 242 23 hepatic hepatic JJ cord-006824-btcdjmfp 242 24 Kupffer Kupffer NNP cord-006824-btcdjmfp 242 25 cells cell NNS cord-006824-btcdjmfp 242 26 [ [ -LRB- cord-006824-btcdjmfp 242 27 3 3 CD cord-006824-btcdjmfp 242 28 , , , cord-006824-btcdjmfp 242 29 25 25 CD cord-006824-btcdjmfp 242 30 ] ] -RRB- cord-006824-btcdjmfp 242 31 . . . cord-006824-btcdjmfp 243 1 In in IN cord-006824-btcdjmfp 243 2 humans human NNS cord-006824-btcdjmfp 243 3 , , , cord-006824-btcdjmfp 243 4 post post JJ cord-006824-btcdjmfp 243 5 - - JJ cord-006824-btcdjmfp 243 6 HCT hct JJ cord-006824-btcdjmfp 243 7 repopulation repopulation NN cord-006824-btcdjmfp 243 8 with with IN cord-006824-btcdjmfp 243 9 donor donor NN cord-006824-btcdjmfp 243 10 - - HYPH cord-006824-btcdjmfp 243 11 derived derive VBN cord-006824-btcdjmfp 243 12 microglia microglia NN cord-006824-btcdjmfp 243 13 requires require VBZ cord-006824-btcdjmfp 243 14 approximately approximately RB cord-006824-btcdjmfp 243 15 1 1 CD cord-006824-btcdjmfp 243 16 year year NN cord-006824-btcdjmfp 243 17 , , , cord-006824-btcdjmfp 243 18 which which WDT cord-006824-btcdjmfp 243 19 may may MD cord-006824-btcdjmfp 243 20 explain explain VB cord-006824-btcdjmfp 243 21 the the DT cord-006824-btcdjmfp 243 22 ineffectiveness ineffectiveness NN cord-006824-btcdjmfp 243 23 of of IN cord-006824-btcdjmfp 243 24 allogeneic allogeneic NN cord-006824-btcdjmfp 243 25 HCT hct NN cord-006824-btcdjmfp 243 26 in in IN cord-006824-btcdjmfp 243 27 stabilizing stabilize VBG cord-006824-btcdjmfp 243 28 or or CC cord-006824-btcdjmfp 243 29 pre pre JJ cord-006824-btcdjmfp 243 30 - - JJ cord-006824-btcdjmfp 243 31 venting venting JJ cord-006824-btcdjmfp 243 32 neurological neurological JJ cord-006824-btcdjmfp 243 33 deterioration deterioration NN cord-006824-btcdjmfp 243 34 in in IN cord-006824-btcdjmfp 243 35 some some DT cord-006824-btcdjmfp 243 36 rapidly rapidly RB cord-006824-btcdjmfp 243 37 progressive progressive JJ cord-006824-btcdjmfp 243 38 storage storage NN cord-006824-btcdjmfp 243 39 diseases disease NNS cord-006824-btcdjmfp 243 40 [ [ -LRB- cord-006824-btcdjmfp 243 41 24 24 CD cord-006824-btcdjmfp 243 42 , , , cord-006824-btcdjmfp 243 43 25 25 CD cord-006824-btcdjmfp 243 44 ] ] -RRB- cord-006824-btcdjmfp 243 45 . . . cord-006824-btcdjmfp 244 1 The the DT cord-006824-btcdjmfp 244 2 availability availability NN cord-006824-btcdjmfp 244 3 of of IN cord-006824-btcdjmfp 244 4 spontaneously spontaneously RB cord-006824-btcdjmfp 244 5 occurring occur VBG cord-006824-btcdjmfp 244 6 heritable heritable JJ cord-006824-btcdjmfp 244 7 animal animal NN cord-006824-btcdjmfp 244 8 models model NNS cord-006824-btcdjmfp 244 9 and and CC cord-006824-btcdjmfp 244 10 the the DT cord-006824-btcdjmfp 244 11 development development NN cord-006824-btcdjmfp 244 12 of of IN cord-006824-btcdjmfp 244 13 transgenic transgenic JJ cord-006824-btcdjmfp 244 14 " " `` cord-006824-btcdjmfp 244 15 knockout knockout NN cord-006824-btcdjmfp 244 16 " " '' cord-006824-btcdjmfp 244 17 lysosomal lysosomal JJ cord-006824-btcdjmfp 244 18 hydrolase hydrolase NN cord-006824-btcdjmfp 244 19 deficient deficient JJ cord-006824-btcdjmfp 244 20 animals animal NNS cord-006824-btcdjmfp 244 21 allows allow VBZ cord-006824-btcdjmfp 244 22 preclinical preclinical JJ cord-006824-btcdjmfp 244 23 evaluation evaluation NN cord-006824-btcdjmfp 244 24 of of IN cord-006824-btcdjmfp 244 25 the the DT cord-006824-btcdjmfp 244 26 biochemical biochemical JJ cord-006824-btcdjmfp 244 27 , , , cord-006824-btcdjmfp 244 28 physiological physiological JJ cord-006824-btcdjmfp 244 29 and and CC cord-006824-btcdjmfp 244 30 clinical clinical JJ cord-006824-btcdjmfp 244 31 effects effect NNS cord-006824-btcdjmfp 244 32 of of IN cord-006824-btcdjmfp 244 33 allogeneic allogeneic NN cord-006824-btcdjmfp 244 34 HCT hct NN cord-006824-btcdjmfp 244 35 in in IN cord-006824-btcdjmfp 244 36 storage storage NN cord-006824-btcdjmfp 244 37 diseases disease NNS cord-006824-btcdjmfp 244 38 . . . cord-006824-btcdjmfp 245 1 The the DT cord-006824-btcdjmfp 245 2 most most RBS cord-006824-btcdjmfp 245 3 extensive extensive JJ cord-006824-btcdjmfp 245 4 studies study NNS cord-006824-btcdjmfp 245 5 of of IN cord-006824-btcdjmfp 245 6 HCT HCT NNP cord-006824-btcdjmfp 245 7 in in IN cord-006824-btcdjmfp 245 8 preclinical preclinical JJ cord-006824-btcdjmfp 245 9 storage storage NN cord-006824-btcdjmfp 245 10 disease disease NN cord-006824-btcdjmfp 245 11 models model NNS cord-006824-btcdjmfp 245 12 have have VBP cord-006824-btcdjmfp 245 13 been be VBN cord-006824-btcdjmfp 245 14 in in IN cord-006824-btcdjmfp 245 15 canine canine JJ cord-006824-btcdjmfp 245 16 α α NN cord-006824-btcdjmfp 245 17 - - HYPH cord-006824-btcdjmfp 245 18 L l NN cord-006824-btcdjmfp 245 19 - - HYPH cord-006824-btcdjmfp 245 20 iduronidase iduronidase NNP cord-006824-btcdjmfp 245 21 deficiency deficiency NN cord-006824-btcdjmfp 245 22 ( ( -LRB- cord-006824-btcdjmfp 245 23 a a DT cord-006824-btcdjmfp 245 24 model model NN cord-006824-btcdjmfp 245 25 of of IN cord-006824-btcdjmfp 245 26 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 245 27 [ [ -LRB- cord-006824-btcdjmfp 245 28 MPS MPS NNP cord-006824-btcdjmfp 245 29 ] ] -RRB- cord-006824-btcdjmfp 245 30 IH IH NNP cord-006824-btcdjmfp 245 31 , , , cord-006824-btcdjmfp 245 32 or or CC cord-006824-btcdjmfp 245 33 Hurler Hurler NNP cord-006824-btcdjmfp 245 34 syndrome syndrome NN cord-006824-btcdjmfp 245 35 ) ) -RRB- cord-006824-btcdjmfp 245 36 [ [ -LRB- cord-006824-btcdjmfp 245 37 3 3 CD cord-006824-btcdjmfp 245 38 , , , cord-006824-btcdjmfp 245 39 8 8 CD cord-006824-btcdjmfp 245 40 , , , cord-006824-btcdjmfp 245 41 45 45 CD cord-006824-btcdjmfp 245 42 ] ] -RRB- cord-006824-btcdjmfp 245 43 , , , cord-006824-btcdjmfp 245 44 murine murine JJ cord-006824-btcdjmfp 245 45 β β NN cord-006824-btcdjmfp 245 46 - - HYPH cord-006824-btcdjmfp 245 47 galactosidase galactosidase NN cord-006824-btcdjmfp 245 48 deficiency deficiency NN cord-006824-btcdjmfp 245 49 ( ( -LRB- cord-006824-btcdjmfp 245 50 a a DT cord-006824-btcdjmfp 245 51 model model NN cord-006824-btcdjmfp 245 52 of of IN cord-006824-btcdjmfp 245 53 MPS MPS NNP cord-006824-btcdjmfp 245 54 VII VII NNP cord-006824-btcdjmfp 245 55 , , , cord-006824-btcdjmfp 245 56 or or CC cord-006824-btcdjmfp 245 57 Sly Sly NNP cord-006824-btcdjmfp 245 58 syndrome syndrome NN cord-006824-btcdjmfp 245 59 ) ) -RRB- cord-006824-btcdjmfp 245 60 [ [ -LRB- cord-006824-btcdjmfp 245 61 4 4 CD cord-006824-btcdjmfp 245 62 , , , cord-006824-btcdjmfp 245 63 42 42 CD cord-006824-btcdjmfp 245 64 , , , cord-006824-btcdjmfp 245 65 55 55 CD cord-006824-btcdjmfp 245 66 ] ] -RRB- cord-006824-btcdjmfp 245 67 , , , cord-006824-btcdjmfp 245 68 and and CC cord-006824-btcdjmfp 245 69 murine murine JJ cord-006824-btcdjmfp 245 70 galactosylceramidase galactosylceramidase NN cord-006824-btcdjmfp 245 71 deficiency deficiency NN cord-006824-btcdjmfp 245 72 ( ( -LRB- cord-006824-btcdjmfp 245 73 the the DT cord-006824-btcdjmfp 245 74 " " `` cord-006824-btcdjmfp 245 75 twitcher twitcher NN cord-006824-btcdjmfp 245 76 " " '' cord-006824-btcdjmfp 245 77 mouse mouse NN cord-006824-btcdjmfp 245 78 , , , cord-006824-btcdjmfp 245 79 a a DT cord-006824-btcdjmfp 245 80 model model NN cord-006824-btcdjmfp 245 81 of of IN cord-006824-btcdjmfp 245 82 the the DT cord-006824-btcdjmfp 245 83 sphingolipidosis sphingolipidosis NNP cord-006824-btcdjmfp 245 84 globoid globoid NNP cord-006824-btcdjmfp 245 85 cell cell NN cord-006824-btcdjmfp 245 86 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 245 87 [ [ -LRB- cord-006824-btcdjmfp 245 88 GCL GCL NNP cord-006824-btcdjmfp 245 89 ] ] -RRB- cord-006824-btcdjmfp 245 90 ) ) -RRB- cord-006824-btcdjmfp 245 91 . . . cord-006824-btcdjmfp 246 1 We -PRON- PRP cord-006824-btcdjmfp 246 2 have have VBP cord-006824-btcdjmfp 246 3 extensively extensively RB cord-006824-btcdjmfp 246 4 studied study VBN cord-006824-btcdjmfp 246 5 HCT hct NN cord-006824-btcdjmfp 246 6 in in IN cord-006824-btcdjmfp 246 7 the the DT cord-006824-btcdjmfp 246 8 twitcher twitcher NN cord-006824-btcdjmfp 246 9 murine murine JJ cord-006824-btcdjmfp 246 10 model model NN cord-006824-btcdjmfp 246 11 [ [ -LRB- cord-006824-btcdjmfp 246 12 49 49 CD cord-006824-btcdjmfp 246 13 ] ] -RRB- cord-006824-btcdjmfp 246 14 , , , cord-006824-btcdjmfp 246 15 which which WDT cord-006824-btcdjmfp 246 16 most most RBS cord-006824-btcdjmfp 246 17 closely closely RB cord-006824-btcdjmfp 246 18 resembles resemble VBZ cord-006824-btcdjmfp 246 19 Krabbe Krabbe NNP cord-006824-btcdjmfp 246 20 disease disease NN cord-006824-btcdjmfp 246 21 , , , cord-006824-btcdjmfp 246 22 the the DT cord-006824-btcdjmfp 246 23 early early JJ cord-006824-btcdjmfp 246 24 infantile infantile JJ cord-006824-btcdjmfp 246 25 form form NN cord-006824-btcdjmfp 246 26 of of IN cord-006824-btcdjmfp 246 27 human human JJ cord-006824-btcdjmfp 246 28 GCL GCL NNP cord-006824-btcdjmfp 246 29 . . . cord-006824-btcdjmfp 247 1 HCT HCT NNP cord-006824-btcdjmfp 247 2 leads lead VBZ cord-006824-btcdjmfp 247 3 to to IN cord-006824-btcdjmfp 247 4 prolonged prolong VBN cord-006824-btcdjmfp 247 5 survival survival NN cord-006824-btcdjmfp 247 6 , , , cord-006824-btcdjmfp 247 7 clinical clinical JJ cord-006824-btcdjmfp 247 8 improvement improvement NN cord-006824-btcdjmfp 247 9 , , , cord-006824-btcdjmfp 247 10 attenuation attenuation NN cord-006824-btcdjmfp 247 11 of of IN cord-006824-btcdjmfp 247 12 hindlimb hindlimb NN cord-006824-btcdjmfp 247 13 paralysis paralysis NN cord-006824-btcdjmfp 247 14 [ [ -LRB- cord-006824-btcdjmfp 247 15 57 57 CD cord-006824-btcdjmfp 247 16 , , , cord-006824-btcdjmfp 247 17 58 58 CD cord-006824-btcdjmfp 247 18 ] ] -RRB- cord-006824-btcdjmfp 247 19 , , , cord-006824-btcdjmfp 247 20 remyelination remyelination NN cord-006824-btcdjmfp 247 21 in in IN cord-006824-btcdjmfp 247 22 peripheral peripheral JJ cord-006824-btcdjmfp 247 23 nerves nerve NNS cord-006824-btcdjmfp 247 24 and and CC cord-006824-btcdjmfp 247 25 CNS CNS NNP cord-006824-btcdjmfp 247 26 [ [ -LRB- cord-006824-btcdjmfp 247 27 58 58 CD cord-006824-btcdjmfp 247 28 ] ] -RRB- cord-006824-btcdjmfp 247 29 , , , cord-006824-btcdjmfp 247 30 and and CC cord-006824-btcdjmfp 247 31 stabilization stabilization NN cord-006824-btcdjmfp 247 32 of of IN cord-006824-btcdjmfp 247 33 motor motor NN cord-006824-btcdjmfp 247 34 nerve nerve NN cord-006824-btcdjmfp 247 35 conduction conduction NN cord-006824-btcdjmfp 247 36 velocities velocity NNS cord-006824-btcdjmfp 247 37 [ [ -LRB- cord-006824-btcdjmfp 247 38 50 50 CD cord-006824-btcdjmfp 247 39 ] ] -RRB- cord-006824-btcdjmfp 247 40 in in IN cord-006824-btcdjmfp 247 41 presymptomatic presymptomatic NNP cord-006824-btcdjmfp 247 42 twitcher twitcher NNP cord-006824-btcdjmfp 247 43 mice mouse NNS cord-006824-btcdjmfp 248 1 but but CC cord-006824-btcdjmfp 248 2 is be VBZ cord-006824-btcdjmfp 248 3 of of IN cord-006824-btcdjmfp 248 4 no no DT cord-006824-btcdjmfp 248 5 benefit benefit NN cord-006824-btcdjmfp 248 6 in in IN cord-006824-btcdjmfp 248 7 symptomatic symptomatic JJ cord-006824-btcdjmfp 248 8 animals animal NNS cord-006824-btcdjmfp 248 9 . . . cord-006824-btcdjmfp 249 1 After after IN cord-006824-btcdjmfp 249 2 HCT HCT NNP cord-006824-btcdjmfp 249 3 , , , cord-006824-btcdjmfp 249 4 galactosylceramidase galactosylceramidase NN cord-006824-btcdjmfp 249 5 is be VBZ cord-006824-btcdjmfp 249 6 present present JJ cord-006824-btcdjmfp 249 7 in in IN cord-006824-btcdjmfp 249 8 the the DT cord-006824-btcdjmfp 249 9 CNS CNS NNP cord-006824-btcdjmfp 249 10 and and CC cord-006824-btcdjmfp 249 11 non non JJ cord-006824-btcdjmfp 249 12 - - JJ cord-006824-btcdjmfp 249 13 neural neural JJ cord-006824-btcdjmfp 249 14 tissues tissue NNS cord-006824-btcdjmfp 249 15 [ [ -LRB- cord-006824-btcdjmfp 249 16 14 14 CD cord-006824-btcdjmfp 249 17 , , , cord-006824-btcdjmfp 249 18 60 60 CD cord-006824-btcdjmfp 249 19 ] ] -RRB- cord-006824-btcdjmfp 249 20 , , , cord-006824-btcdjmfp 249 21 and and CC cord-006824-btcdjmfp 249 22 levels level NNS cord-006824-btcdjmfp 249 23 of of IN cord-006824-btcdjmfp 249 24 the the DT cord-006824-btcdjmfp 249 25 toxic toxic JJ cord-006824-btcdjmfp 249 26 metabolite metabolite NN cord-006824-btcdjmfp 249 27 psychosine psychosine NN cord-006824-btcdjmfp 249 28 ( ( -LRB- cord-006824-btcdjmfp 249 29 galactosylsphingosine galactosylsphingosine NNP cord-006824-btcdjmfp 249 30 ) ) -RRB- cord-006824-btcdjmfp 249 31 [ [ -LRB- cord-006824-btcdjmfp 249 32 15 15 CD cord-006824-btcdjmfp 249 33 ] ] -RRB- cord-006824-btcdjmfp 249 34 , , , cord-006824-btcdjmfp 249 35 are be VBP cord-006824-btcdjmfp 249 36 significantly significantly RB cord-006824-btcdjmfp 249 37 decreased decrease VBN cord-006824-btcdjmfp 249 38 in in IN cord-006824-btcdjmfp 249 39 the the DT cord-006824-btcdjmfp 249 40 CNS CNS NNP cord-006824-btcdjmfp 249 41 [ [ -LRB- cord-006824-btcdjmfp 249 42 14 14 CD cord-006824-btcdjmfp 249 43 ] ] -RRB- cord-006824-btcdjmfp 249 44 . . . cord-006824-btcdjmfp 250 1 Postnatal postnatal JJ cord-006824-btcdjmfp 250 2 HCT hct NN cord-006824-btcdjmfp 250 3 is be VBZ cord-006824-btcdjmfp 250 4 not not RB cord-006824-btcdjmfp 250 5 curative curative JJ cord-006824-btcdjmfp 250 6 in in IN cord-006824-btcdjmfp 250 7 murine murine JJ cord-006824-btcdjmfp 250 8 GCL GCL NNP cord-006824-btcdjmfp 250 9 , , , cord-006824-btcdjmfp 250 10 most most RBS cord-006824-btcdjmfp 250 11 likely likely JJ cord-006824-btcdjmfp 250 12 because because IN cord-006824-btcdjmfp 250 13 repopulation repopulation NN cord-006824-btcdjmfp 250 14 of of IN cord-006824-btcdjmfp 250 15 the the DT cord-006824-btcdjmfp 250 16 CNS CNS NNP cord-006824-btcdjmfp 250 17 and and CC cord-006824-btcdjmfp 250 18 peripheral peripheral JJ cord-006824-btcdjmfp 250 19 nervous nervous JJ cord-006824-btcdjmfp 250 20 system system NN cord-006824-btcdjmfp 250 21 with with IN cord-006824-btcdjmfp 250 22 donor donor NN cord-006824-btcdjmfp 250 23 cells cell NNS cord-006824-btcdjmfp 250 24 does do VBZ cord-006824-btcdjmfp 250 25 not not RB cord-006824-btcdjmfp 250 26 occur occur VB cord-006824-btcdjmfp 250 27 rapidly rapidly RB cord-006824-btcdjmfp 250 28 enough enough RB cord-006824-btcdjmfp 250 29 to to TO cord-006824-btcdjmfp 250 30 stabilize stabilize VB cord-006824-btcdjmfp 250 31 the the DT cord-006824-btcdjmfp 250 32 progressive progressive JJ cord-006824-btcdjmfp 250 33 demyelination demyelination NN cord-006824-btcdjmfp 250 34 . . . cord-006824-btcdjmfp 251 1 Murine murine JJ cord-006824-btcdjmfp 251 2 GCL GCL NNP cord-006824-btcdjmfp 251 3 may may MD cord-006824-btcdjmfp 251 4 be be VB cord-006824-btcdjmfp 251 5 an an DT cord-006824-btcdjmfp 251 6 important important JJ cord-006824-btcdjmfp 251 7 model model NN cord-006824-btcdjmfp 251 8 for for IN cord-006824-btcdjmfp 251 9 critical critical JJ cord-006824-btcdjmfp 251 10 evaluation evaluation NN cord-006824-btcdjmfp 251 11 of of IN cord-006824-btcdjmfp 251 12 the the DT cord-006824-btcdjmfp 251 13 effects effect NNS cord-006824-btcdjmfp 251 14 of of IN cord-006824-btcdjmfp 251 15 intrauterine intrauterine JJ cord-006824-btcdjmfp 251 16 cellular cellular JJ cord-006824-btcdjmfp 251 17 transplantation transplantation NN cord-006824-btcdjmfp 251 18 for for IN cord-006824-btcdjmfp 251 19 infantile infantile JJ cord-006824-btcdjmfp 251 20 - - HYPH cord-006824-btcdjmfp 251 21 onset onset NN cord-006824-btcdjmfp 251 22 sphingolipidosis sphingolipidosis NN cord-006824-btcdjmfp 251 23 . . . cord-006824-btcdjmfp 252 1 Several several JJ cord-006824-btcdjmfp 252 2 recent recent JJ cord-006824-btcdjmfp 252 3 reports report NNS cord-006824-btcdjmfp 252 4 have have VBP cord-006824-btcdjmfp 252 5 summarized summarize VBN cord-006824-btcdjmfp 252 6 the the DT cord-006824-btcdjmfp 252 7 results result NNS cord-006824-btcdjmfp 252 8 of of IN cord-006824-btcdjmfp 252 9 allogeneic allogeneic NN cord-006824-btcdjmfp 252 10 HCT hct NN cord-006824-btcdjmfp 252 11 for for IN cord-006824-btcdjmfp 252 12 storage storage NN cord-006824-btcdjmfp 252 13 diseases disease NNS cord-006824-btcdjmfp 252 14 and and CC cord-006824-btcdjmfp 252 15 ALD ALD NNP cord-006824-btcdjmfp 252 16 [ [ -LRB- cord-006824-btcdjmfp 252 17 27 27 CD cord-006824-btcdjmfp 252 18 , , , cord-006824-btcdjmfp 252 19 44 44 CD cord-006824-btcdjmfp 252 20 , , , cord-006824-btcdjmfp 252 21 56 56 CD cord-006824-btcdjmfp 252 22 ] ] -RRB- cord-006824-btcdjmfp 252 23 . . . cord-006824-btcdjmfp 253 1 This this DT cord-006824-btcdjmfp 253 2 review review NN cord-006824-btcdjmfp 253 3 will will MD cord-006824-btcdjmfp 253 4 focus focus VB cord-006824-btcdjmfp 253 5 on on IN cord-006824-btcdjmfp 253 6 current current JJ cord-006824-btcdjmfp 253 7 concepts concept NNS cord-006824-btcdjmfp 253 8 of of IN cord-006824-btcdjmfp 253 9 allogeneic allogeneic NN cord-006824-btcdjmfp 253 10 HCT hct NN cord-006824-btcdjmfp 253 11 for for IN cord-006824-btcdjmfp 253 12 MPS MPS NNP cord-006824-btcdjmfp 253 13 IH IH NNP cord-006824-btcdjmfp 253 14 ( ( -LRB- cord-006824-btcdjmfp 253 15 Hurler Hurler NNP cord-006824-btcdjmfp 253 16 syndrome syndrome NN cord-006824-btcdjmfp 253 17 ) ) -RRB- cord-006824-btcdjmfp 253 18 , , , cord-006824-btcdjmfp 253 19 globoid globoid JJ cord-006824-btcdjmfp 253 20 cell cell NN cord-006824-btcdjmfp 253 21 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 253 22 and and CC cord-006824-btcdjmfp 253 23 ceramidase ceramidase NN cord-006824-btcdjmfp 253 24 deficiency deficiency NN cord-006824-btcdjmfp 253 25 ( ( -LRB- cord-006824-btcdjmfp 253 26 Farber Farber NNP cord-006824-btcdjmfp 253 27 disease disease NN cord-006824-btcdjmfp 253 28 ) ) -RRB- cord-006824-btcdjmfp 253 29 . . . cord-006824-btcdjmfp 254 1 The the DT cord-006824-btcdjmfp 254 2 prognosis prognosis NN cord-006824-btcdjmfp 254 3 of of IN cord-006824-btcdjmfp 254 4 untreated untreated JJ cord-006824-btcdjmfp 254 5 MPS MPS NNP cord-006824-btcdjmfp 254 6 IH IH NNP cord-006824-btcdjmfp 254 7 ( ( -LRB- cord-006824-btcdjmfp 254 8 α α NN cord-006824-btcdjmfp 254 9 - - HYPH cord-006824-btcdjmfp 254 10 L l NN cord-006824-btcdjmfp 254 11 - - HYPH cord-006824-btcdjmfp 254 12 iduronidase iduronidase JJ cord-006824-btcdjmfp 254 13 deficiency deficiency NN cord-006824-btcdjmfp 254 14 ) ) -RRB- cord-006824-btcdjmfp 254 15 is be VBZ cord-006824-btcdjmfp 254 16 poor poor JJ cord-006824-btcdjmfp 254 17 , , , cord-006824-btcdjmfp 254 18 with with IN cord-006824-btcdjmfp 254 19 a a DT cord-006824-btcdjmfp 254 20 median median JJ cord-006824-btcdjmfp 254 21 survival survival NN cord-006824-btcdjmfp 254 22 of of IN cord-006824-btcdjmfp 254 23 4.5 4.5 CD cord-006824-btcdjmfp 254 24 years year NNS cord-006824-btcdjmfp 254 25 and and CC cord-006824-btcdjmfp 254 26 with with IN cord-006824-btcdjmfp 254 27 very very RB cord-006824-btcdjmfp 254 28 few few JJ cord-006824-btcdjmfp 254 29 children child NNS cord-006824-btcdjmfp 254 30 surviving survive VBG cord-006824-btcdjmfp 254 31 into into IN cord-006824-btcdjmfp 254 32 the the DT cord-006824-btcdjmfp 254 33 second second JJ cord-006824-btcdjmfp 254 34 decade decade NN cord-006824-btcdjmfp 254 35 of of IN cord-006824-btcdjmfp 254 36 life life NN cord-006824-btcdjmfp 254 37 [ [ -LRB- cord-006824-btcdjmfp 254 38 23 23 CD cord-006824-btcdjmfp 254 39 ] ] -RRB- cord-006824-btcdjmfp 254 40 . . . cord-006824-btcdjmfp 255 1 In in IN cord-006824-btcdjmfp 255 2 contrast contrast NN cord-006824-btcdjmfp 255 3 , , , cord-006824-btcdjmfp 255 4 survival survival NN cord-006824-btcdjmfp 255 5 after after IN cord-006824-btcdjmfp 255 6 HCT hct NN cord-006824-btcdjmfp 255 7 in in IN cord-006824-btcdjmfp 255 8 children child NNS cord-006824-btcdjmfp 255 9 with with IN cord-006824-btcdjmfp 255 10 MPS MPS NNP cord-006824-btcdjmfp 255 11 IH IH NNP cord-006824-btcdjmfp 255 12 is be VBZ cord-006824-btcdjmfp 255 13 75 75 CD cord-006824-btcdjmfp 255 14 % % NN cord-006824-btcdjmfp 255 15 after after IN cord-006824-btcdjmfp 255 16 bone bone NN cord-006824-btcdjmfp 255 17 marrow marrow NN cord-006824-btcdjmfp 255 18 transplantation transplantation NN cord-006824-btcdjmfp 255 19 ( ( -LRB- cord-006824-btcdjmfp 255 20 BMT BMT NNP cord-006824-btcdjmfp 255 21 ) ) -RRB- cord-006824-btcdjmfp 255 22 from from IN cord-006824-btcdjmfp 255 23 HLA HLA NNP cord-006824-btcdjmfp 255 24 - - HYPH cord-006824-btcdjmfp 255 25 identical identical JJ cord-006824-btcdjmfp 255 26 siblings sibling NNS cord-006824-btcdjmfp 255 27 , , , cord-006824-btcdjmfp 255 28 53 53 CD cord-006824-btcdjmfp 255 29 % % NN cord-006824-btcdjmfp 255 30 after after IN cord-006824-btcdjmfp 255 31 BMT BMT NNP cord-006824-btcdjmfp 255 32 from from IN cord-006824-btcdjmfp 255 33 HLA HLA NNP cord-006824-btcdjmfp 255 34 - - HYPH cord-006824-btcdjmfp 255 35 mismatched mismatch VBN cord-006824-btcdjmfp 255 36 relatives relative NNS cord-006824-btcdjmfp 255 37 , , , cord-006824-btcdjmfp 255 38 and and CC cord-006824-btcdjmfp 255 39 49 49 CD cord-006824-btcdjmfp 255 40 % % NN cord-006824-btcdjmfp 255 41 after after IN cord-006824-btcdjmfp 255 42 BMT BMT NNP cord-006824-btcdjmfp 255 43 from from IN cord-006824-btcdjmfp 255 44 unrelated unrelated JJ cord-006824-btcdjmfp 255 45 donors donor NNS cord-006824-btcdjmfp 255 46 [ [ -LRB- cord-006824-btcdjmfp 255 47 36 36 CD cord-006824-btcdjmfp 255 48 , , , cord-006824-btcdjmfp 255 49 37 37 CD cord-006824-btcdjmfp 255 50 ] ] -RRB- cord-006824-btcdjmfp 255 51 . . . cord-006824-btcdjmfp 256 1 Hepatosplenomegaly Hepatosplenomegaly NNP cord-006824-btcdjmfp 256 2 , , , cord-006824-btcdjmfp 256 3 joint joint JJ cord-006824-btcdjmfp 256 4 mobility mobility NN cord-006824-btcdjmfp 256 5 , , , cord-006824-btcdjmfp 256 6 and and CC cord-006824-btcdjmfp 256 7 upper upper JJ cord-006824-btcdjmfp 256 8 airway airway NN cord-006824-btcdjmfp 256 9 obstruction obstruction NN cord-006824-btcdjmfp 256 10 in in IN cord-006824-btcdjmfp 256 11 MPS MPS NNP cord-006824-btcdjmfp 256 12 IH IH NNP cord-006824-btcdjmfp 256 13 resolve resolve VB cord-006824-btcdjmfp 256 14 within within IN cord-006824-btcdjmfp 256 15 months month NNS cord-006824-btcdjmfp 256 16 to to IN cord-006824-btcdjmfp 256 17 a a DT cord-006824-btcdjmfp 256 18 year year NN cord-006824-btcdjmfp 256 19 after after IN cord-006824-btcdjmfp 256 20 HCT HCT NNP cord-006824-btcdjmfp 256 21 . . . cord-006824-btcdjmfp 257 1 Corneal corneal JJ cord-006824-btcdjmfp 257 2 clouding clouding NN cord-006824-btcdjmfp 257 3 stabilizes stabilize VBZ cord-006824-btcdjmfp 257 4 or or CC cord-006824-btcdjmfp 257 5 slowly slowly RB cord-006824-btcdjmfp 257 6 resolves resolve VBZ cord-006824-btcdjmfp 257 7 [ [ -LRB- cord-006824-btcdjmfp 257 8 9 9 CD cord-006824-btcdjmfp 257 9 ] ] -RRB- cord-006824-btcdjmfp 257 10 , , , cord-006824-btcdjmfp 257 11 and and CC cord-006824-btcdjmfp 257 12 visual visual JJ cord-006824-btcdjmfp 257 13 acuity acuity NN cord-006824-btcdjmfp 257 14 may may MD cord-006824-btcdjmfp 257 15 improve improve VB cord-006824-btcdjmfp 257 16 even even RB cord-006824-btcdjmfp 257 17 without without IN cord-006824-btcdjmfp 257 18 regression regression NN cord-006824-btcdjmfp 257 19 of of IN cord-006824-btcdjmfp 257 20 corneal corneal JJ cord-006824-btcdjmfp 257 21 clouding clouding NN cord-006824-btcdjmfp 257 22 . . . cord-006824-btcdjmfp 258 1 Unfortunately unfortunately RB cord-006824-btcdjmfp 258 2 HCT HCT NNP cord-006824-btcdjmfp 258 3 does do VBZ cord-006824-btcdjmfp 258 4 not not RB cord-006824-btcdjmfp 258 5 correct correct VB cord-006824-btcdjmfp 258 6 the the DT cord-006824-btcdjmfp 258 7 skeletal skeletal JJ cord-006824-btcdjmfp 258 8 manifestations manifestation NNS cord-006824-btcdjmfp 258 9 ( ( -LRB- cord-006824-btcdjmfp 258 10 dysostosis dysostosis NNP cord-006824-btcdjmfp 258 11 multiplex multiplex NN cord-006824-btcdjmfp 258 12 ) ) -RRB- cord-006824-btcdjmfp 258 13 of of IN cord-006824-btcdjmfp 258 14 MPS MPS NNP cord-006824-btcdjmfp 258 15 IH IH NNP cord-006824-btcdjmfp 258 16 , , , cord-006824-btcdjmfp 258 17 which which WDT cord-006824-btcdjmfp 258 18 are be VBP cord-006824-btcdjmfp 258 19 due due JJ cord-006824-btcdjmfp 258 20 to to IN cord-006824-btcdjmfp 258 21 metabolic metabolic JJ cord-006824-btcdjmfp 258 22 dysfunction dysfunction NN cord-006824-btcdjmfp 258 23 in in IN cord-006824-btcdjmfp 258 24 chondrocytes chondrocyte NNS cord-006824-btcdjmfp 258 25 and and CC cord-006824-btcdjmfp 258 26 osteoblasts osteoblast NNS cord-006824-btcdjmfp 258 27 that that WDT cord-006824-btcdjmfp 258 28 arise arise VBP cord-006824-btcdjmfp 258 29 from from IN cord-006824-btcdjmfp 258 30 mesenchymal mesenchymal JJ cord-006824-btcdjmfp 258 31 precursors precursor NNS cord-006824-btcdjmfp 258 32 . . . cord-006824-btcdjmfp 259 1 The the DT cord-006824-btcdjmfp 259 2 orthopaedic orthopaedic JJ cord-006824-btcdjmfp 259 3 complications complication NNS cord-006824-btcdjmfp 259 4 of of IN cord-006824-btcdjmfp 259 5 MPS MPS NNP cord-006824-btcdjmfp 259 6 IH IH NNP cord-006824-btcdjmfp 259 7 require require VB cord-006824-btcdjmfp 259 8 ongoing ongoing JJ cord-006824-btcdjmfp 259 9 evaluation evaluation NN cord-006824-btcdjmfp 259 10 and and CC cord-006824-btcdjmfp 259 11 surgical surgical JJ cord-006824-btcdjmfp 259 12 management management NN cord-006824-btcdjmfp 259 13 even even RB cord-006824-btcdjmfp 259 14 after after IN cord-006824-btcdjmfp 259 15 HCT HCT NNP cord-006824-btcdjmfp 259 16 [ [ -LRB- cord-006824-btcdjmfp 259 17 7 7 CD cord-006824-btcdjmfp 259 18 ] ] -RRB- cord-006824-btcdjmfp 259 19 . . . cord-006824-btcdjmfp 260 1 Mental mental JJ cord-006824-btcdjmfp 260 2 retardation retardation NN cord-006824-btcdjmfp 260 3 is be VBZ cord-006824-btcdjmfp 260 4 a a DT cord-006824-btcdjmfp 260 5 hallmark hallmark NN cord-006824-btcdjmfp 260 6 of of IN cord-006824-btcdjmfp 260 7 untreated untreated JJ cord-006824-btcdjmfp 260 8 MPS MPS NNP cord-006824-btcdjmfp 260 9 IH IH NNP cord-006824-btcdjmfp 260 10 [ [ -LRB- cord-006824-btcdjmfp 260 11 53 53 CD cord-006824-btcdjmfp 260 12 ] ] -RRB- cord-006824-btcdjmfp 260 13 , , , cord-006824-btcdjmfp 260 14 and and CC cord-006824-btcdjmfp 260 15 both both DT cord-006824-btcdjmfp 260 16 age age NN cord-006824-btcdjmfp 260 17 and and CC cord-006824-btcdjmfp 260 18 neurodevelopmental neurodevelopmental JJ cord-006824-btcdjmfp 260 19 status status NN cord-006824-btcdjmfp 260 20 are be VBP cord-006824-btcdjmfp 260 21 important important JJ cord-006824-btcdjmfp 260 22 determinants determinant NNS cord-006824-btcdjmfp 260 23 of of IN cord-006824-btcdjmfp 260 24 outcome outcome NN cord-006824-btcdjmfp 260 25 after after IN cord-006824-btcdjmfp 260 26 HCT HCT NNP cord-006824-btcdjmfp 260 27 . . . cord-006824-btcdjmfp 261 1 When when WRB cord-006824-btcdjmfp 261 2 carried carry VBN cord-006824-btcdjmfp 261 3 out out RP cord-006824-btcdjmfp 261 4 in in IN cord-006824-btcdjmfp 261 5 patients patient NNS cord-006824-btcdjmfp 261 6 under under IN cord-006824-btcdjmfp 261 7 age age NN cord-006824-btcdjmfp 261 8 2 2 CD cord-006824-btcdjmfp 261 9 years year NNS cord-006824-btcdjmfp 261 10 , , , cord-006824-btcdjmfp 261 11 HCT hct NN cord-006824-btcdjmfp 261 12 preserves preserve VBZ cord-006824-btcdjmfp 261 13 neurocognitive neurocognitive JJ cord-006824-btcdjmfp 261 14 function function NN cord-006824-btcdjmfp 261 15 and and CC cord-006824-btcdjmfp 261 16 prevents prevent NNS cord-006824-btcdjmfp 261 17 or or CC cord-006824-btcdjmfp 261 18 reverses reverse VBZ cord-006824-btcdjmfp 261 19 increased increase VBN cord-006824-btcdjmfp 261 20 intracranial intracranial JJ cord-006824-btcdjmfp 261 21 pressure pressure NN cord-006824-btcdjmfp 261 22 . . . cord-006824-btcdjmfp 262 1 This this DT cord-006824-btcdjmfp 262 2 favorable favorable JJ cord-006824-btcdjmfp 262 3 outcome outcome NN cord-006824-btcdjmfp 262 4 is be VBZ cord-006824-btcdjmfp 262 5 in in IN cord-006824-btcdjmfp 262 6 part part NN cord-006824-btcdjmfp 262 7 due due IN cord-006824-btcdjmfp 262 8 to to IN cord-006824-btcdjmfp 262 9 the the DT cord-006824-btcdjmfp 262 10 fact fact NN cord-006824-btcdjmfp 262 11 that that IN cord-006824-btcdjmfp 262 12 the the DT cord-006824-btcdjmfp 262 13 developmental developmental JJ cord-006824-btcdjmfp 262 14 quotient quotient NN cord-006824-btcdjmfp 262 15 ( ( -LRB- cord-006824-btcdjmfp 262 16 DQ DQ NNP cord-006824-btcdjmfp 262 17 ) ) -RRB- cord-006824-btcdjmfp 262 18 falls fall VBZ cord-006824-btcdjmfp 262 19 below below IN cord-006824-btcdjmfp 262 20 70 70 CD cord-006824-btcdjmfp 262 21 in in IN cord-006824-btcdjmfp 262 22 most most JJS cord-006824-btcdjmfp 262 23 children child NNS cord-006824-btcdjmfp 262 24 with with IN cord-006824-btcdjmfp 262 25 MPS MPS NNP cord-006824-btcdjmfp 262 26 IH IH NNP cord-006824-btcdjmfp 262 27 after after IN cord-006824-btcdjmfp 262 28 age age NN cord-006824-btcdjmfp 262 29 2 2 CD cord-006824-btcdjmfp 262 30 years year NNS cord-006824-btcdjmfp 262 31 [ [ -LRB- cord-006824-btcdjmfp 262 32 43 43 CD cord-006824-btcdjmfp 262 33 ] ] -RRB- cord-006824-btcdjmfp 262 34 . . . cord-006824-btcdjmfp 263 1 In in IN cord-006824-btcdjmfp 263 2 general general JJ cord-006824-btcdjmfp 263 3 , , , cord-006824-btcdjmfp 263 4 children child NNS cord-006824-btcdjmfp 263 5 with with IN cord-006824-btcdjmfp 263 6 MPS MPS NNP cord-006824-btcdjmfp 263 7 IH IH NNP cord-006824-btcdjmfp 263 8 with with IN cord-006824-btcdjmfp 263 9 normal normal JJ cord-006824-btcdjmfp 263 10 intelligence intelligence NN cord-006824-btcdjmfp 263 11 before before IN cord-006824-btcdjmfp 263 12 HCT HCT NNP cord-006824-btcdjmfp 263 13 maintain maintain VBP cord-006824-btcdjmfp 263 14 that that DT cord-006824-btcdjmfp 263 15 level level NN cord-006824-btcdjmfp 263 16 of of IN cord-006824-btcdjmfp 263 17 cognitive cognitive JJ cord-006824-btcdjmfp 263 18 functioning functioning NN cord-006824-btcdjmfp 263 19 after after IN cord-006824-btcdjmfp 263 20 transplant transplant NN cord-006824-btcdjmfp 263 21 [ [ -LRB- cord-006824-btcdjmfp 263 22 36 36 CD cord-006824-btcdjmfp 263 23 , , , cord-006824-btcdjmfp 263 24 43 43 CD cord-006824-btcdjmfp 263 25 , , , cord-006824-btcdjmfp 263 26 54 54 CD cord-006824-btcdjmfp 263 27 ] ] -RRB- cord-006824-btcdjmfp 263 28 , , , cord-006824-btcdjmfp 263 29 but but CC cord-006824-btcdjmfp 263 30 those those DT cord-006824-btcdjmfp 263 31 with with IN cord-006824-btcdjmfp 263 32 significant significant JJ cord-006824-btcdjmfp 263 33 neurocognitive neurocognitive NNS cord-006824-btcdjmfp 263 34 impairment impairment NN cord-006824-btcdjmfp 263 35 ( ( -LRB- cord-006824-btcdjmfp 263 36 e.g. e.g. RB cord-006824-btcdjmfp 263 37 , , , cord-006824-btcdjmfp 263 38 DQ DQ NNP cord-006824-btcdjmfp 263 39 below below IN cord-006824-btcdjmfp 263 40 70 70 CD cord-006824-btcdjmfp 263 41 ) ) -RRB- cord-006824-btcdjmfp 263 42 at at IN cord-006824-btcdjmfp 263 43 HCT HCT NNP cord-006824-btcdjmfp 263 44 have have VBP cord-006824-btcdjmfp 263 45 progressive progressive JJ cord-006824-btcdjmfp 263 46 deterioration deterioration NN cord-006824-btcdjmfp 263 47 and and CC cord-006824-btcdjmfp 263 48 do do VBP cord-006824-btcdjmfp 263 49 not not RB cord-006824-btcdjmfp 263 50 benefit benefit VB cord-006824-btcdjmfp 263 51 from from IN cord-006824-btcdjmfp 263 52 the the DT cord-006824-btcdjmfp 263 53 procedure procedure NN cord-006824-btcdjmfp 263 54 . . . cord-006824-btcdjmfp 264 1 Globoid globoid JJ cord-006824-btcdjmfp 264 2 cell cell NN cord-006824-btcdjmfp 264 3 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 264 4 ( ( -LRB- cord-006824-btcdjmfp 264 5 galactosylceramidase galactosylceramidase NNP cord-006824-btcdjmfp 264 6 deficiency deficiency NN cord-006824-btcdjmfp 264 7 ) ) -RRB- cord-006824-btcdjmfp 264 8 is be VBZ cord-006824-btcdjmfp 264 9 one one CD cord-006824-btcdjmfp 264 10 of of IN cord-006824-btcdjmfp 264 11 the the DT cord-006824-btcdjmfp 264 12 sphingolipidoses sphingolipidose NNS cord-006824-btcdjmfp 264 13 , , , cord-006824-btcdjmfp 264 14 which which WDT cord-006824-btcdjmfp 264 15 are be VBP cord-006824-btcdjmfp 264 16 characterized characterize VBN cord-006824-btcdjmfp 264 17 by by IN cord-006824-btcdjmfp 264 18 demyelin demyelin JJ cord-006824-btcdjmfp 264 19 - - HYPH cord-006824-btcdjmfp 264 20 ation ation NN cord-006824-btcdjmfp 264 21 of of IN cord-006824-btcdjmfp 264 22 the the DT cord-006824-btcdjmfp 264 23 CNS CNS NNP cord-006824-btcdjmfp 264 24 and/or and/or CC cord-006824-btcdjmfp 264 25 peripheral peripheral JJ cord-006824-btcdjmfp 264 26 nervous nervous JJ cord-006824-btcdjmfp 264 27 system system NN cord-006824-btcdjmfp 264 28 because because IN cord-006824-btcdjmfp 264 29 of of IN cord-006824-btcdjmfp 264 30 deficiencies deficiency NNS cord-006824-btcdjmfp 264 31 in in IN cord-006824-btcdjmfp 264 32 specific specific JJ cord-006824-btcdjmfp 264 33 acid acid NN cord-006824-btcdjmfp 264 34 hydrolases hydrolase NNS cord-006824-btcdjmfp 264 35 involved involve VBN cord-006824-btcdjmfp 264 36 in in IN cord-006824-btcdjmfp 264 37 the the DT cord-006824-btcdjmfp 264 38 metabolism metabolism NN cord-006824-btcdjmfp 264 39 of of IN cord-006824-btcdjmfp 264 40 sphingomyelin sphingomyelin NN cord-006824-btcdjmfp 264 41 , , , cord-006824-btcdjmfp 264 42 gangliosides ganglioside NNS cord-006824-btcdjmfp 264 43 and and CC cord-006824-btcdjmfp 264 44 cerebrosides cerebroside NNS cord-006824-btcdjmfp 264 45 [ [ -LRB- cord-006824-btcdjmfp 264 46 48 48 CD cord-006824-btcdjmfp 264 47 ] ] -RRB- cord-006824-btcdjmfp 264 48 . . . cord-006824-btcdjmfp 265 1 Characteristic characteristic JJ cord-006824-btcdjmfp 265 2 globoid globoid NN cord-006824-btcdjmfp 265 3 cells cell NNS cord-006824-btcdjmfp 265 4 , , , cord-006824-btcdjmfp 265 5 derived derive VBN cord-006824-btcdjmfp 265 6 from from IN cord-006824-btcdjmfp 265 7 microglia microglia NNS cord-006824-btcdjmfp 265 8 or or CC cord-006824-btcdjmfp 265 9 CNS CNS NNP cord-006824-btcdjmfp 265 10 macrophages macrophage NNS cord-006824-btcdjmfp 265 11 and and CC cord-006824-btcdjmfp 265 12 containing contain VBG cord-006824-btcdjmfp 265 13 periodic periodic JJ cord-006824-btcdjmfp 265 14 acid acid NN cord-006824-btcdjmfp 265 15 - - HYPH cord-006824-btcdjmfp 265 16 Schiff Schiff NNP cord-006824-btcdjmfp 265 17 ( ( -LRB- cord-006824-btcdjmfp 265 18 PAS)-positive pas)-positive JJ cord-006824-btcdjmfp 265 19 myelin myelin NN cord-006824-btcdjmfp 265 20 breakdown breakdown NN cord-006824-btcdjmfp 265 21 material material NN cord-006824-btcdjmfp 265 22 , , , cord-006824-btcdjmfp 265 23 are be VBP cord-006824-btcdjmfp 265 24 present present JJ cord-006824-btcdjmfp 265 25 in in IN cord-006824-btcdjmfp 265 26 the the DT cord-006824-btcdjmfp 265 27 brains brain NNS cord-006824-btcdjmfp 265 28 , , , cord-006824-btcdjmfp 265 29 spinal spinal JJ cord-006824-btcdjmfp 265 30 cord cord NN cord-006824-btcdjmfp 265 31 and and CC cord-006824-btcdjmfp 265 32 peripheral peripheral JJ cord-006824-btcdjmfp 265 33 nerves nerve NNS cord-006824-btcdjmfp 265 34 . . . cord-006824-btcdjmfp 266 1 Interestingly interestingly RB cord-006824-btcdjmfp 266 2 , , , cord-006824-btcdjmfp 266 3 the the DT cord-006824-btcdjmfp 266 4 widespread widespread JJ cord-006824-btcdjmfp 266 5 demyelination demyelination NN cord-006824-btcdjmfp 266 6 in in IN cord-006824-btcdjmfp 266 7 GCL GCL NNP cord-006824-btcdjmfp 266 8 is be VBZ cord-006824-btcdjmfp 266 9 due due JJ cord-006824-btcdjmfp 266 10 to to IN cord-006824-btcdjmfp 266 11 accumulation accumulation NN cord-006824-btcdjmfp 266 12 of of IN cord-006824-btcdjmfp 266 13 psychosine psychosine NN cord-006824-btcdjmfp 266 14 ( ( -LRB- cord-006824-btcdjmfp 266 15 galactosylsphingosine galactosylsphingosine NNP cord-006824-btcdjmfp 266 16 ) ) -RRB- cord-006824-btcdjmfp 266 17 , , , cord-006824-btcdjmfp 266 18 which which WDT cord-006824-btcdjmfp 266 19 is be VBZ cord-006824-btcdjmfp 266 20 derived derive VBN cord-006824-btcdjmfp 266 21 from from IN cord-006824-btcdjmfp 266 22 the the DT cord-006824-btcdjmfp 266 23 substrate substrate JJ cord-006824-btcdjmfp 266 24 galactosylceramide galactosylceramide NN cord-006824-btcdjmfp 266 25 and and CC cord-006824-btcdjmfp 266 26 is be VBZ cord-006824-btcdjmfp 266 27 toxic toxic JJ cord-006824-btcdjmfp 266 28 to to IN cord-006824-btcdjmfp 266 29 both both DT cord-006824-btcdjmfp 266 30 oligodendroglia oligodendroglia NNS cord-006824-btcdjmfp 266 31 and and CC cord-006824-btcdjmfp 266 32 Schwann Schwann NNP cord-006824-btcdjmfp 266 33 cells cell NNS cord-006824-btcdjmfp 266 34 [ [ -LRB- cord-006824-btcdjmfp 266 35 15 15 CD cord-006824-btcdjmfp 266 36 ] ] -RRB- cord-006824-btcdjmfp 266 37 . . . cord-006824-btcdjmfp 267 1 The the DT cord-006824-btcdjmfp 267 2 four four CD cord-006824-btcdjmfp 267 3 clinical clinical JJ cord-006824-btcdjmfp 267 4 phenotypes phenotype NNS cord-006824-btcdjmfp 267 5 of of IN cord-006824-btcdjmfp 267 6 human human JJ cord-006824-btcdjmfp 267 7 GCL GCL NNP cord-006824-btcdjmfp 267 8 vary vary VBP cord-006824-btcdjmfp 267 9 in in IN cord-006824-btcdjmfp 267 10 clinical clinical JJ cord-006824-btcdjmfp 267 11 manifestations manifestation NNS cord-006824-btcdjmfp 267 12 and and CC cord-006824-btcdjmfp 267 13 tempo tempo NN cord-006824-btcdjmfp 267 14 of of IN cord-006824-btcdjmfp 267 15 disease disease NN cord-006824-btcdjmfp 267 16 progression progression NN cord-006824-btcdjmfp 267 17 . . . cord-006824-btcdjmfp 268 1 Patients patient NNS cord-006824-btcdjmfp 268 2 with with IN cord-006824-btcdjmfp 268 3 early early JJ cord-006824-btcdjmfp 268 4 ( ( -LRB- cord-006824-btcdjmfp 268 5 age age NN cord-006824-btcdjmfp 268 6 of of IN cord-006824-btcdjmfp 268 7 onset onset NN cord-006824-btcdjmfp 268 8 , , , cord-006824-btcdjmfp 268 9 3 3 CD cord-006824-btcdjmfp 268 10 to to TO cord-006824-btcdjmfp 268 11 6 6 CD cord-006824-btcdjmfp 268 12 months month NNS cord-006824-btcdjmfp 268 13 ) ) -RRB- cord-006824-btcdjmfp 268 14 or or CC cord-006824-btcdjmfp 268 15 late late JJ cord-006824-btcdjmfp 268 16 ( ( -LRB- cord-006824-btcdjmfp 268 17 age age NN cord-006824-btcdjmfp 268 18 of of IN cord-006824-btcdjmfp 268 19 onset onset NN cord-006824-btcdjmfp 268 20 , , , cord-006824-btcdjmfp 268 21 6 6 CD cord-006824-btcdjmfp 268 22 months month NNS cord-006824-btcdjmfp 268 23 to to IN cord-006824-btcdjmfp 268 24 3 3 CD cord-006824-btcdjmfp 268 25 years year NNS cord-006824-btcdjmfp 268 26 ) ) -RRB- cord-006824-btcdjmfp 268 27 infantile infantile JJ cord-006824-btcdjmfp 268 28 GCL GCL NNP cord-006824-btcdjmfp 268 29 have have VBP cord-006824-btcdjmfp 268 30 profound profound JJ cord-006824-btcdjmfp 268 31 psychomotor psychomotor JJ cord-006824-btcdjmfp 268 32 retardation retardation NN cord-006824-btcdjmfp 268 33 , , , cord-006824-btcdjmfp 268 34 failure failure NN cord-006824-btcdjmfp 268 35 to to TO cord-006824-btcdjmfp 268 36 thrive thrive VB cord-006824-btcdjmfp 268 37 , , , cord-006824-btcdjmfp 268 38 spasticity spasticity NN cord-006824-btcdjmfp 268 39 , , , cord-006824-btcdjmfp 268 40 seizures seizure NNS cord-006824-btcdjmfp 268 41 , , , cord-006824-btcdjmfp 268 42 optic optic JJ cord-006824-btcdjmfp 268 43 atrophy atrophy NN cord-006824-btcdjmfp 268 44 and and CC cord-006824-btcdjmfp 268 45 cortical cortical JJ cord-006824-btcdjmfp 268 46 blindness blindness NN cord-006824-btcdjmfp 268 47 [ [ -LRB- cord-006824-btcdjmfp 268 48 10 10 CD cord-006824-btcdjmfp 268 49 ] ] -RRB- cord-006824-btcdjmfp 268 50 . . . cord-006824-btcdjmfp 269 1 Juvenile juvenile JJ cord-006824-btcdjmfp 269 2 GCL GCL NNP cord-006824-btcdjmfp 269 3 affects affect VBZ cord-006824-btcdjmfp 269 4 children child NNS cord-006824-btcdjmfp 269 5 from from IN cord-006824-btcdjmfp 269 6 3 3 CD cord-006824-btcdjmfp 269 7 to to TO cord-006824-btcdjmfp 269 8 10 10 CD cord-006824-btcdjmfp 269 9 years year NNS cord-006824-btcdjmfp 269 10 of of IN cord-006824-btcdjmfp 269 11 age age NN cord-006824-btcdjmfp 269 12 , , , cord-006824-btcdjmfp 269 13 with with IN cord-006824-btcdjmfp 269 14 insidious insidious JJ cord-006824-btcdjmfp 269 15 onset onset NN cord-006824-btcdjmfp 269 16 and and CC cord-006824-btcdjmfp 269 17 progression progression NN cord-006824-btcdjmfp 269 18 of of IN cord-006824-btcdjmfp 269 19 visual visual JJ cord-006824-btcdjmfp 269 20 loss loss NN cord-006824-btcdjmfp 269 21 , , , cord-006824-btcdjmfp 269 22 lower low JJR cord-006824-btcdjmfp 269 23 extremity extremity NN cord-006824-btcdjmfp 269 24 spasticity spasticity NN cord-006824-btcdjmfp 269 25 , , , cord-006824-btcdjmfp 269 26 and and CC cord-006824-btcdjmfp 269 27 in in IN cord-006824-btcdjmfp 269 28 some some DT cord-006824-btcdjmfp 269 29 patients patient NNS cord-006824-btcdjmfp 269 30 dementia dementia NN cord-006824-btcdjmfp 269 31 . . . cord-006824-btcdjmfp 270 1 Adult adult NN cord-006824-btcdjmfp 270 2 GCL GCL NNP cord-006824-btcdjmfp 270 3 occurs occur VBZ cord-006824-btcdjmfp 270 4 in in IN cord-006824-btcdjmfp 270 5 patients patient NNS cord-006824-btcdjmfp 270 6 over over IN cord-006824-btcdjmfp 270 7 age age NN cord-006824-btcdjmfp 270 8 10 10 CD cord-006824-btcdjmfp 270 9 years year NNS cord-006824-btcdjmfp 270 10 and and CC cord-006824-btcdjmfp 270 11 is be VBZ cord-006824-btcdjmfp 270 12 characterized characterize VBN cord-006824-btcdjmfp 270 13 by by IN cord-006824-btcdjmfp 270 14 slowly slowly RB cord-006824-btcdjmfp 270 15 progressive progressive JJ cord-006824-btcdjmfp 270 16 difficulty difficulty NN cord-006824-btcdjmfp 270 17 in in IN cord-006824-btcdjmfp 270 18 walking walking NN cord-006824-btcdjmfp 270 19 , , , cord-006824-btcdjmfp 270 20 long long JJ cord-006824-btcdjmfp 270 21 - - HYPH cord-006824-btcdjmfp 270 22 tract tract NN cord-006824-btcdjmfp 270 23 signs sign NNS cord-006824-btcdjmfp 270 24 , , , cord-006824-btcdjmfp 270 25 asymmetric asymmetric JJ cord-006824-btcdjmfp 270 26 weakness weakness NN cord-006824-btcdjmfp 270 27 of of IN cord-006824-btcdjmfp 270 28 the the DT cord-006824-btcdjmfp 270 29 extremities extremity NNS cord-006824-btcdjmfp 270 30 , , , cord-006824-btcdjmfp 270 31 and and CC cord-006824-btcdjmfp 270 32 difficulties difficulty NNS cord-006824-btcdjmfp 270 33 with with IN cord-006824-btcdjmfp 270 34 coordination coordination NN cord-006824-btcdjmfp 270 35 and and CC cord-006824-btcdjmfp 270 36 balance balance NN cord-006824-btcdjmfp 270 37 , , , cord-006824-btcdjmfp 270 38 but but CC cord-006824-btcdjmfp 270 39 intellect intellect NN cord-006824-btcdjmfp 270 40 is be VBZ cord-006824-btcdjmfp 270 41 generally generally RB cord-006824-btcdjmfp 270 42 unaffected unaffected JJ cord-006824-btcdjmfp 270 43 [ [ -LRB- cord-006824-btcdjmfp 270 44 20 20 CD cord-006824-btcdjmfp 270 45 ] ] -RRB- cord-006824-btcdjmfp 270 46 . . . cord-006824-btcdjmfp 271 1 Allogeneic Allogeneic NNP cord-006824-btcdjmfp 271 2 HCT HCT NNP cord-006824-btcdjmfp 271 3 is be VBZ cord-006824-btcdjmfp 271 4 not not RB cord-006824-btcdjmfp 271 5 curative curative JJ cord-006824-btcdjmfp 271 6 in in IN cord-006824-btcdjmfp 271 7 symptomatic symptomatic JJ cord-006824-btcdjmfp 271 8 early early JJ cord-006824-btcdjmfp 271 9 infantile infantile JJ cord-006824-btcdjmfp 271 10 GCL GCL NNP cord-006824-btcdjmfp 271 11 ( ( -LRB- cord-006824-btcdjmfp 271 12 Krabbe Krabbe NNP cord-006824-btcdjmfp 271 13 disease disease NN cord-006824-btcdjmfp 271 14 ) ) -RRB- cord-006824-btcdjmfp 271 15 , , , cord-006824-btcdjmfp 271 16 in in IN cord-006824-btcdjmfp 271 17 which which WDT cord-006824-btcdjmfp 271 18 neurodegeneration neurodegeneration NN cord-006824-btcdjmfp 271 19 persists persist VBZ cord-006824-btcdjmfp 271 20 despite despite IN cord-006824-btcdjmfp 271 21 post post JJ cord-006824-btcdjmfp 271 22 - - JJ cord-006824-btcdjmfp 271 23 transplant transplant JJ cord-006824-btcdjmfp 271 24 biochemical biochemical JJ cord-006824-btcdjmfp 271 25 improvement improvement NN cord-006824-btcdjmfp 271 26 [ [ -LRB- cord-006824-btcdjmfp 271 27 23 23 CD cord-006824-btcdjmfp 271 28 , , , cord-006824-btcdjmfp 271 29 26 26 CD cord-006824-btcdjmfp 271 30 ] ] -RRB- cord-006824-btcdjmfp 271 31 , , , cord-006824-btcdjmfp 271 32 analogous analogous JJ cord-006824-btcdjmfp 271 33 to to IN cord-006824-btcdjmfp 271 34 observations observation NNS cord-006824-btcdjmfp 271 35 in in IN cord-006824-btcdjmfp 271 36 the the DT cord-006824-btcdjmfp 271 37 preclinical preclinical JJ cord-006824-btcdjmfp 271 38 studies study NNS cord-006824-btcdjmfp 271 39 of of IN cord-006824-btcdjmfp 271 40 HCT HCT NNP cord-006824-btcdjmfp 271 41 in in IN cord-006824-btcdjmfp 271 42 murine murine JJ cord-006824-btcdjmfp 271 43 GCL GCL NNP cord-006824-btcdjmfp 271 44 . . . cord-006824-btcdjmfp 272 1 Although although IN cord-006824-btcdjmfp 272 2 very very RB cord-006824-btcdjmfp 272 3 limited limited JJ cord-006824-btcdjmfp 272 4 experience experience NN cord-006824-btcdjmfp 272 5 suggests suggest VBZ cord-006824-btcdjmfp 272 6 that that IN cord-006824-btcdjmfp 272 7 presymptomatic presymptomatic JJ cord-006824-btcdjmfp 272 8 infants infant NNS cord-006824-btcdjmfp 272 9 with with IN cord-006824-btcdjmfp 272 10 infantile infantile JJ cord-006824-btcdjmfp 272 11 GCL GCL NNP cord-006824-btcdjmfp 272 12 may may MD cord-006824-btcdjmfp 272 13 benefit benefit VB cord-006824-btcdjmfp 272 14 from from IN cord-006824-btcdjmfp 272 15 HCT HCT NNP cord-006824-btcdjmfp 272 16 [ [ -LRB- cord-006824-btcdjmfp 272 17 26 26 CD cord-006824-btcdjmfp 272 18 ] ] -RRB- cord-006824-btcdjmfp 272 19 , , , cord-006824-btcdjmfp 272 20 early early JJ cord-006824-btcdjmfp 272 21 identification identification NN cord-006824-btcdjmfp 272 22 of of IN cord-006824-btcdjmfp 272 23 the the DT cord-006824-btcdjmfp 272 24 affected affect VBN cord-006824-btcdjmfp 272 25 infant infant NN cord-006824-btcdjmfp 272 26 and and CC cord-006824-btcdjmfp 272 27 of of IN cord-006824-btcdjmfp 272 28 a a DT cord-006824-btcdjmfp 272 29 suitable suitable JJ cord-006824-btcdjmfp 272 30 HCT hct NN cord-006824-btcdjmfp 272 31 donor donor NN cord-006824-btcdjmfp 272 32 are be VBP cord-006824-btcdjmfp 272 33 obvious obvious JJ cord-006824-btcdjmfp 272 34 practical practical JJ cord-006824-btcdjmfp 272 35 challenges challenge NNS cord-006824-btcdjmfp 272 36 to to IN cord-006824-btcdjmfp 272 37 this this DT cord-006824-btcdjmfp 272 38 therapeutic therapeutic JJ cord-006824-btcdjmfp 272 39 strategy strategy NN cord-006824-btcdjmfp 272 40 . . . cord-006824-btcdjmfp 273 1 The the DT cord-006824-btcdjmfp 273 2 role role NN cord-006824-btcdjmfp 273 3 for for IN cord-006824-btcdjmfp 273 4 allogeneic allogeneic NN cord-006824-btcdjmfp 273 5 HCT HCT NNP cord-006824-btcdjmfp 273 6 is be VBZ cord-006824-btcdjmfp 273 7 more more RBR cord-006824-btcdjmfp 273 8 firmly firmly RB cord-006824-btcdjmfp 273 9 established establish VBN cord-006824-btcdjmfp 273 10 in in IN cord-006824-btcdjmfp 273 11 patients patient NNS cord-006824-btcdjmfp 273 12 with with IN cord-006824-btcdjmfp 273 13 presymptomatic presymptomatic NN cord-006824-btcdjmfp 273 14 or or CC cord-006824-btcdjmfp 273 15 minimally minimally RB cord-006824-btcdjmfp 273 16 symptomatic symptomatic JJ cord-006824-btcdjmfp 273 17 juvenile juvenile JJ cord-006824-btcdjmfp 273 18 or or CC cord-006824-btcdjmfp 273 19 adult adult NN cord-006824-btcdjmfp 273 20 GCL GCL NNP cord-006824-btcdjmfp 273 21 , , , cord-006824-btcdjmfp 273 22 in in IN cord-006824-btcdjmfp 273 23 whom whom WP cord-006824-btcdjmfp 273 24 HCT HCT NNP cord-006824-btcdjmfp 273 25 leads lead VBZ cord-006824-btcdjmfp 273 26 to to IN cord-006824-btcdjmfp 273 27 stabilization stabilization NN cord-006824-btcdjmfp 273 28 and and CC cord-006824-btcdjmfp 273 29 gradual gradual JJ cord-006824-btcdjmfp 273 30 improvement improvement NN cord-006824-btcdjmfp 273 31 in in IN cord-006824-btcdjmfp 273 32 clinical clinical JJ cord-006824-btcdjmfp 273 33 , , , cord-006824-btcdjmfp 273 34 neurological neurological JJ cord-006824-btcdjmfp 273 35 and and CC cord-006824-btcdjmfp 273 36 neurocognitive neurocognitive JJ cord-006824-btcdjmfp 273 37 status status NN cord-006824-btcdjmfp 273 38 [ [ -LRB- cord-006824-btcdjmfp 273 39 13 13 CD cord-006824-btcdjmfp 273 40 , , , cord-006824-btcdjmfp 273 41 26 26 CD cord-006824-btcdjmfp 273 42 , , , cord-006824-btcdjmfp 273 43 43 43 CD cord-006824-btcdjmfp 273 44 ] ] -RRB- cord-006824-btcdjmfp 273 45 . . . cord-006824-btcdjmfp 274 1 Of of IN cord-006824-btcdjmfp 274 2 the the DT cord-006824-btcdjmfp 274 3 six six CD cord-006824-btcdjmfp 274 4 phenotypes phenotype NNS cord-006824-btcdjmfp 274 5 of of IN cord-006824-btcdjmfp 274 6 ceramidase ceramidase NN cord-006824-btcdjmfp 274 7 deficiency deficiency NN cord-006824-btcdjmfp 274 8 [ [ -LRB- cord-006824-btcdjmfp 274 9 29 29 CD cord-006824-btcdjmfp 274 10 ] ] -RRB- cord-006824-btcdjmfp 274 11 , , , cord-006824-btcdjmfp 274 12 at at RB cord-006824-btcdjmfp 274 13 least least JJS cord-006824-btcdjmfp 274 14 50 50 CD cord-006824-btcdjmfp 274 15 % % NN cord-006824-btcdjmfp 274 16 of of IN cord-006824-btcdjmfp 274 17 patients patient NNS cord-006824-btcdjmfp 274 18 have have VBP cord-006824-btcdjmfp 274 19 the the DT cord-006824-btcdjmfp 274 20 classic classic JJ cord-006824-btcdjmfp 274 21 infantile infantile JJ cord-006824-btcdjmfp 274 22 form form NN cord-006824-btcdjmfp 274 23 , , , cord-006824-btcdjmfp 274 24 or or CC cord-006824-btcdjmfp 274 25 Farber Farber NNP cord-006824-btcdjmfp 274 26 disease disease NN cord-006824-btcdjmfp 274 27 phenotype phenotype NN cord-006824-btcdjmfp 274 28 . . . cord-006824-btcdjmfp 275 1 Affected affected JJ cord-006824-btcdjmfp 275 2 infants infant NNS cord-006824-btcdjmfp 275 3 have have VBP cord-006824-btcdjmfp 275 4 painful painful JJ cord-006824-btcdjmfp 275 5 joint joint JJ cord-006824-btcdjmfp 275 6 swelling swelling NN cord-006824-btcdjmfp 275 7 , , , cord-006824-btcdjmfp 275 8 multiple multiple JJ cord-006824-btcdjmfp 275 9 painful painful JJ cord-006824-btcdjmfp 275 10 subcutaneous subcutaneous JJ cord-006824-btcdjmfp 275 11 nodules nodule NNS cord-006824-btcdjmfp 275 12 , , , cord-006824-btcdjmfp 275 13 hoarseness hoarseness NN cord-006824-btcdjmfp 275 14 , , , cord-006824-btcdjmfp 275 15 swallowing swallow VBG cord-006824-btcdjmfp 275 16 difficulties difficulty NNS cord-006824-btcdjmfp 275 17 , , , cord-006824-btcdjmfp 275 18 and and CC cord-006824-btcdjmfp 275 19 failure failure NN cord-006824-btcdjmfp 275 20 to to TO cord-006824-btcdjmfp 275 21 thrive thrive VB cord-006824-btcdjmfp 275 22 [ [ -LRB- cord-006824-btcdjmfp 275 23 6 6 CD cord-006824-btcdjmfp 275 24 ] ] -RRB- cord-006824-btcdjmfp 275 25 . . . cord-006824-btcdjmfp 276 1 Microscopic microscopic JJ cord-006824-btcdjmfp 276 2 examination examination NN cord-006824-btcdjmfp 276 3 of of IN cord-006824-btcdjmfp 276 4 the the DT cord-006824-btcdjmfp 276 5 nodules nodule NNS cord-006824-btcdjmfp 276 6 shows show VBZ cord-006824-btcdjmfp 276 7 granulomata granulomata NNP cord-006824-btcdjmfp 276 8 containing contain VBG cord-006824-btcdjmfp 276 9 ceramide ceramide NN cord-006824-btcdjmfp 276 10 - - HYPH cord-006824-btcdjmfp 276 11 laden laden NN cord-006824-btcdjmfp 276 12 macrophages macrophage NNS cord-006824-btcdjmfp 276 13 . . . cord-006824-btcdjmfp 277 1 Granulomata Granulomata NNP cord-006824-btcdjmfp 277 2 in in IN cord-006824-btcdjmfp 277 3 the the DT cord-006824-btcdjmfp 277 4 aerodigestive aerodigestive JJ cord-006824-btcdjmfp 277 5 tract tract NN cord-006824-btcdjmfp 277 6 cause cause NN cord-006824-btcdjmfp 277 7 hoarseness hoarseness NN cord-006824-btcdjmfp 277 8 and and CC cord-006824-btcdjmfp 277 9 deglutition deglutition NN cord-006824-btcdjmfp 277 10 problems problem NNS cord-006824-btcdjmfp 277 11 . . . cord-006824-btcdjmfp 278 1 Hepatomegaly Hepatomegaly NNP cord-006824-btcdjmfp 278 2 , , , cord-006824-btcdjmfp 278 3 recurrent recurrent JJ cord-006824-btcdjmfp 278 4 pulmonary pulmonary JJ cord-006824-btcdjmfp 278 5 infections infection NNS cord-006824-btcdjmfp 278 6 and and CC cord-006824-btcdjmfp 278 7 respiratory respiratory JJ cord-006824-btcdjmfp 278 8 difficulties difficulty NNS cord-006824-btcdjmfp 278 9 are be VBP cord-006824-btcdjmfp 278 10 common common JJ cord-006824-btcdjmfp 278 11 and and CC cord-006824-btcdjmfp 278 12 due due JJ cord-006824-btcdjmfp 278 13 in in IN cord-006824-btcdjmfp 278 14 large large JJ cord-006824-btcdjmfp 278 15 part part NN cord-006824-btcdjmfp 278 16 to to IN cord-006824-btcdjmfp 278 17 organ organ NN cord-006824-btcdjmfp 278 18 infiltration infiltration NN cord-006824-btcdjmfp 278 19 by by IN cord-006824-btcdjmfp 278 20 ceramide ceramide NN cord-006824-btcdjmfp 278 21 - - HYPH cord-006824-btcdjmfp 278 22 laden laden JJ cord-006824-btcdjmfp 278 23 macrophages macrophage NNS cord-006824-btcdjmfp 278 24 . . . cord-006824-btcdjmfp 279 1 Infants infant NNS cord-006824-btcdjmfp 279 2 with with IN cord-006824-btcdjmfp 279 3 Farber Farber NNP cord-006824-btcdjmfp 279 4 disease disease NN cord-006824-btcdjmfp 279 5 die die VBP cord-006824-btcdjmfp 279 6 with with IN cord-006824-btcdjmfp 279 7 progressive progressive JJ cord-006824-btcdjmfp 279 8 and and CC cord-006824-btcdjmfp 279 9 profound profound JJ cord-006824-btcdjmfp 279 10 psychomotor psychomotor JJ cord-006824-btcdjmfp 279 11 retardation retardation NN cord-006824-btcdjmfp 279 12 at at IN cord-006824-btcdjmfp 279 13 a a DT cord-006824-btcdjmfp 279 14 mean mean JJ cord-006824-btcdjmfp 279 15 age age NN cord-006824-btcdjmfp 279 16 of of IN cord-006824-btcdjmfp 279 17 18 18 CD cord-006824-btcdjmfp 279 18 to to TO cord-006824-btcdjmfp 279 19 20 20 CD cord-006824-btcdjmfp 279 20 months month NNS cord-006824-btcdjmfp 279 21 [ [ -LRB- cord-006824-btcdjmfp 279 22 29 29 CD cord-006824-btcdjmfp 279 23 ] ] -RRB- cord-006824-btcdjmfp 279 24 . . . cord-006824-btcdjmfp 280 1 Two two CD cord-006824-btcdjmfp 280 2 infants infant NNS cord-006824-btcdjmfp 280 3 with with IN cord-006824-btcdjmfp 280 4 Farber Farber NNP cord-006824-btcdjmfp 280 5 disease disease NN cord-006824-btcdjmfp 280 6 received receive VBD cord-006824-btcdjmfp 280 7 allogeneic allogeneic IN cord-006824-btcdjmfp 280 8 BMT BMT NNP cord-006824-btcdjmfp 280 9 at at IN cord-006824-btcdjmfp 280 10 18 18 CD cord-006824-btcdjmfp 280 11 months month NNS cord-006824-btcdjmfp 280 12 [ [ -LRB- cord-006824-btcdjmfp 280 13 47 47 CD cord-006824-btcdjmfp 280 14 ] ] -RRB- cord-006824-btcdjmfp 280 15 and and CC cord-006824-btcdjmfp 280 16 9 9 CD cord-006824-btcdjmfp 280 17 months month NNS cord-006824-btcdjmfp 280 18 [ [ -LRB- cord-006824-btcdjmfp 280 19 61 61 CD cord-006824-btcdjmfp 280 20 ] ] -RRB- cord-006824-btcdjmfp 280 21 of of IN cord-006824-btcdjmfp 280 22 age age NN cord-006824-btcdjmfp 280 23 , , , cord-006824-btcdjmfp 280 24 respectively respectively RB cord-006824-btcdjmfp 280 25 . . . cord-006824-btcdjmfp 281 1 Subcutaneous subcutaneous JJ cord-006824-btcdjmfp 281 2 nodules nodule NNS cord-006824-btcdjmfp 281 3 , , , cord-006824-btcdjmfp 281 4 joint joint JJ cord-006824-btcdjmfp 281 5 pain pain NN cord-006824-btcdjmfp 281 6 and and CC cord-006824-btcdjmfp 281 7 hoarseness hoarseness NN cord-006824-btcdjmfp 281 8 regressed regress VBN cord-006824-btcdjmfp 281 9 within within IN cord-006824-btcdjmfp 281 10 2 2 CD cord-006824-btcdjmfp 281 11 months month NNS cord-006824-btcdjmfp 281 12 after after IN cord-006824-btcdjmfp 281 13 transplant transplant NN cord-006824-btcdjmfp 281 14 in in IN cord-006824-btcdjmfp 281 15 both both DT cord-006824-btcdjmfp 281 16 patients patient NNS cord-006824-btcdjmfp 281 17 . . . cord-006824-btcdjmfp 282 1 The the DT cord-006824-btcdjmfp 282 2 older old JJR cord-006824-btcdjmfp 282 3 patient patient NN cord-006824-btcdjmfp 282 4 had have VBD cord-006824-btcdjmfp 282 5 progressive progressive JJ cord-006824-btcdjmfp 282 6 neurodegeneration neurodegeneration NN cord-006824-btcdjmfp 282 7 and and CC cord-006824-btcdjmfp 282 8 died die VBD cord-006824-btcdjmfp 282 9 6 6 CD cord-006824-btcdjmfp 282 10 months month NNS cord-006824-btcdjmfp 282 11 after after IN cord-006824-btcdjmfp 282 12 BMT BMT NNP cord-006824-btcdjmfp 282 13 . . . cord-006824-btcdjmfp 283 1 The the DT cord-006824-btcdjmfp 283 2 younger young JJR cord-006824-btcdjmfp 283 3 patient patient JJ cord-006824-btcdjmfp 283 4 , , , cord-006824-btcdjmfp 283 5 who who WP cord-006824-btcdjmfp 283 6 had have VBD cord-006824-btcdjmfp 283 7 mild mild JJ cord-006824-btcdjmfp 283 8 developmental developmental JJ cord-006824-btcdjmfp 283 9 delay delay NN cord-006824-btcdjmfp 283 10 and and CC cord-006824-btcdjmfp 283 11 slight slight JJ cord-006824-btcdjmfp 283 12 hypotonia hypotonia NNS cord-006824-btcdjmfp 283 13 at at IN cord-006824-btcdjmfp 283 14 BMT BMT NNP cord-006824-btcdjmfp 283 15 , , , cord-006824-btcdjmfp 283 16 had have VBD cord-006824-btcdjmfp 283 17 progressive progressive JJ cord-006824-btcdjmfp 283 18 psychomotor psychomotor JJ cord-006824-btcdjmfp 283 19 retardation retardation NN cord-006824-btcdjmfp 283 20 and and CC cord-006824-btcdjmfp 283 21 graft graft NN cord-006824-btcdjmfp 283 22 failure failure NN cord-006824-btcdjmfp 283 23 , , , cord-006824-btcdjmfp 283 24 with with IN cord-006824-btcdjmfp 283 25 a a DT cord-006824-btcdjmfp 283 26 developmental developmental JJ cord-006824-btcdjmfp 283 27 age age NN cord-006824-btcdjmfp 283 28 of of IN cord-006824-btcdjmfp 283 29 4 4 CD cord-006824-btcdjmfp 283 30 months month NNS cord-006824-btcdjmfp 283 31 at at IN cord-006824-btcdjmfp 283 32 chronological chronological JJ cord-006824-btcdjmfp 283 33 age age NN cord-006824-btcdjmfp 283 34 32 32 CD cord-006824-btcdjmfp 283 35 months month NNS cord-006824-btcdjmfp 283 36 . . . cord-006824-btcdjmfp 284 1 Despite despite IN cord-006824-btcdjmfp 284 2 loss loss NN cord-006824-btcdjmfp 284 3 of of IN cord-006824-btcdjmfp 284 4 donor donor NN cord-006824-btcdjmfp 284 5 cell cell NN cord-006824-btcdjmfp 284 6 engraftment engraftment NN cord-006824-btcdjmfp 284 7 , , , cord-006824-btcdjmfp 284 8 levels level NNS cord-006824-btcdjmfp 284 9 of of IN cord-006824-btcdjmfp 284 10 ceramidase ceramidase NN cord-006824-btcdjmfp 284 11 in in IN cord-006824-btcdjmfp 284 12 the the DT cord-006824-btcdjmfp 284 13 peripheral peripheral JJ cord-006824-btcdjmfp 284 14 blood blood NN cord-006824-btcdjmfp 284 15 leukocytes leukocyte NNS cord-006824-btcdjmfp 284 16 remained remain VBD cord-006824-btcdjmfp 284 17 in in IN cord-006824-btcdjmfp 284 18 the the DT cord-006824-btcdjmfp 284 19 donor donor NN cord-006824-btcdjmfp 284 20 heterozygous heterozygous JJ cord-006824-btcdjmfp 284 21 range range NN cord-006824-btcdjmfp 284 22 , , , cord-006824-btcdjmfp 284 23 suggesting suggest VBG cord-006824-btcdjmfp 284 24 ongoing ongoing JJ cord-006824-btcdjmfp 284 25 production production NN cord-006824-btcdjmfp 284 26 of of IN cord-006824-btcdjmfp 284 27 ceramidase ceramidase NN cord-006824-btcdjmfp 284 28 by by IN cord-006824-btcdjmfp 284 29 non non JJ cord-006824-btcdjmfp 284 30 - - JJ cord-006824-btcdjmfp 284 31 circulating circulating JJ cord-006824-btcdjmfp 284 32 donor donor NN cord-006824-btcdjmfp 284 33 cells cell NNS cord-006824-btcdjmfp 284 34 and and CC cord-006824-btcdjmfp 284 35 hydrolase hydrolase NN cord-006824-btcdjmfp 284 36 uptake uptake NN cord-006824-btcdjmfp 284 37 by by IN cord-006824-btcdjmfp 284 38 recipient recipient NN cord-006824-btcdjmfp 284 39 blood blood NN cord-006824-btcdjmfp 284 40 cells cell NNS cord-006824-btcdjmfp 284 41 [ [ -LRB- cord-006824-btcdjmfp 284 42 61 61 CD cord-006824-btcdjmfp 284 43 ] ] -RRB- cord-006824-btcdjmfp 284 44 . . . cord-006824-btcdjmfp 285 1 These these DT cord-006824-btcdjmfp 285 2 limited limited JJ cord-006824-btcdjmfp 285 3 observations observation NNS cord-006824-btcdjmfp 285 4 indicate indicate VBP cord-006824-btcdjmfp 285 5 that that IN cord-006824-btcdjmfp 285 6 HCT HCT NNP cord-006824-btcdjmfp 285 7 does do VBZ cord-006824-btcdjmfp 285 8 not not RB cord-006824-btcdjmfp 285 9 stabilize stabilize VB cord-006824-btcdjmfp 285 10 the the DT cord-006824-btcdjmfp 285 11 rapid rapid JJ cord-006824-btcdjmfp 285 12 neurological neurological JJ cord-006824-btcdjmfp 285 13 deterioration deterioration NN cord-006824-btcdjmfp 285 14 in in IN cord-006824-btcdjmfp 285 15 classic classic JJ cord-006824-btcdjmfp 285 16 Farber Farber NNP cord-006824-btcdjmfp 285 17 disease disease NN cord-006824-btcdjmfp 285 18 . . . cord-006824-btcdjmfp 286 1 Among among IN cord-006824-btcdjmfp 286 2 new new JJ cord-006824-btcdjmfp 286 3 approaches approach NNS cord-006824-btcdjmfp 286 4 for for IN cord-006824-btcdjmfp 286 5 treatment treatment NN cord-006824-btcdjmfp 286 6 of of IN cord-006824-btcdjmfp 286 7 metabolic metabolic JJ cord-006824-btcdjmfp 286 8 disorders disorder NNS cord-006824-btcdjmfp 286 9 by by IN cord-006824-btcdjmfp 286 10 cellular cellular JJ cord-006824-btcdjmfp 286 11 transplantation transplantation NN cord-006824-btcdjmfp 286 12 , , , cord-006824-btcdjmfp 286 13 intrauterine intrauterine JJ cord-006824-btcdjmfp 286 14 HCT hct NN cord-006824-btcdjmfp 286 15 may may MD cord-006824-btcdjmfp 286 16 be be VB cord-006824-btcdjmfp 286 17 worthy worthy JJ cord-006824-btcdjmfp 286 18 of of IN cord-006824-btcdjmfp 286 19 exploration exploration NN cord-006824-btcdjmfp 286 20 , , , cord-006824-btcdjmfp 286 21 especially especially RB cord-006824-btcdjmfp 286 22 in in IN cord-006824-btcdjmfp 286 23 the the DT cord-006824-btcdjmfp 286 24 rapidly rapidly RB cord-006824-btcdjmfp 286 25 progressive progressive JJ cord-006824-btcdjmfp 286 26 infantile infantile JJ cord-006824-btcdjmfp 286 27 forms form NNS cord-006824-btcdjmfp 286 28 in in IN cord-006824-btcdjmfp 286 29 which which WDT cord-006824-btcdjmfp 286 30 postnatal postnatal JJ cord-006824-btcdjmfp 286 31 HCT hct NN cord-006824-btcdjmfp 286 32 is be VBZ cord-006824-btcdjmfp 286 33 not not RB cord-006824-btcdjmfp 286 34 effective effective JJ cord-006824-btcdjmfp 286 35 . . . cord-006824-btcdjmfp 287 1 The the DT cord-006824-btcdjmfp 287 2 major major JJ cord-006824-btcdjmfp 287 3 limitation limitation NN cord-006824-btcdjmfp 287 4 to to IN cord-006824-btcdjmfp 287 5 this this DT cord-006824-btcdjmfp 287 6 approach approach NN cord-006824-btcdjmfp 287 7 is be VBZ cord-006824-btcdjmfp 287 8 the the DT cord-006824-btcdjmfp 287 9 low low JJ cord-006824-btcdjmfp 287 10 levels level NNS cord-006824-btcdjmfp 287 11 of of IN cord-006824-btcdjmfp 287 12 donor donor NN cord-006824-btcdjmfp 287 13 cell cell NN cord-006824-btcdjmfp 287 14 engraftment engraftment NN cord-006824-btcdjmfp 287 15 , , , cord-006824-btcdjmfp 287 16 which which WDT cord-006824-btcdjmfp 287 17 may may MD cord-006824-btcdjmfp 287 18 not not RB cord-006824-btcdjmfp 287 19 provide provide VB cord-006824-btcdjmfp 287 20 sufficient sufficient JJ cord-006824-btcdjmfp 287 21 hydrolase hydrolase NN cord-006824-btcdjmfp 287 22 or or CC cord-006824-btcdjmfp 287 23 metabolically metabolically RB cord-006824-btcdjmfp 287 24 active active JJ cord-006824-btcdjmfp 287 25 cells cell NNS cord-006824-btcdjmfp 287 26 to to TO cord-006824-btcdjmfp 287 27 correct correct VB cord-006824-btcdjmfp 287 28 the the DT cord-006824-btcdjmfp 287 29 underlying underlying JJ cord-006824-btcdjmfp 287 30 biochemical biochemical JJ cord-006824-btcdjmfp 287 31 defect defect NN cord-006824-btcdjmfp 287 32 [ [ -LRB- cord-006824-btcdjmfp 287 33 17 17 CD cord-006824-btcdjmfp 287 34 ] ] -RRB- cord-006824-btcdjmfp 287 35 . . . cord-006824-btcdjmfp 288 1 Allogeneic Allogeneic NNP cord-006824-btcdjmfp 288 2 HCT hct NN cord-006824-btcdjmfp 288 3 using use VBG cord-006824-btcdjmfp 288 4 reduced reduce VBN cord-006824-btcdjmfp 288 5 - - HYPH cord-006824-btcdjmfp 288 6 intensity intensity NN cord-006824-btcdjmfp 288 7 nonmyeloablative nonmyeloablative JJ cord-006824-btcdjmfp 288 8 preparative preparative JJ cord-006824-btcdjmfp 288 9 regimens regimen NNS cord-006824-btcdjmfp 288 10 may may MD cord-006824-btcdjmfp 288 11 be be VB cord-006824-btcdjmfp 288 12 considered consider VBN cord-006824-btcdjmfp 288 13 in in IN cord-006824-btcdjmfp 288 14 some some DT cord-006824-btcdjmfp 288 15 indolent indolent JJ cord-006824-btcdjmfp 288 16 forms form NNS cord-006824-btcdjmfp 288 17 of of IN cord-006824-btcdjmfp 288 18 storage storage NN cord-006824-btcdjmfp 288 19 diseases disease NNS cord-006824-btcdjmfp 288 20 , , , cord-006824-btcdjmfp 288 21 providing provide VBG cord-006824-btcdjmfp 288 22 gradual gradual JJ cord-006824-btcdjmfp 288 23 donor donor NN cord-006824-btcdjmfp 288 24 cell cell NN cord-006824-btcdjmfp 288 25 engraftment engraftment NN cord-006824-btcdjmfp 288 26 without without IN cord-006824-btcdjmfp 288 27 the the DT cord-006824-btcdjmfp 288 28 risk risk NN cord-006824-btcdjmfp 288 29 of of IN cord-006824-btcdjmfp 288 30 aplasia aplasia NNP cord-006824-btcdjmfp 288 31 and and CC cord-006824-btcdjmfp 288 32 other other JJ cord-006824-btcdjmfp 288 33 short short JJ cord-006824-btcdjmfp 288 34 - - HYPH cord-006824-btcdjmfp 288 35 and and CC cord-006824-btcdjmfp 288 36 long long JJ cord-006824-btcdjmfp 288 37 - - HYPH cord-006824-btcdjmfp 288 38 term term NN cord-006824-btcdjmfp 288 39 toxicities toxicity NNS cord-006824-btcdjmfp 288 40 associated associate VBN cord-006824-btcdjmfp 288 41 with with IN cord-006824-btcdjmfp 288 42 intensive intensive JJ cord-006824-btcdjmfp 288 43 marrow marrow NN cord-006824-btcdjmfp 288 44 - - HYPH cord-006824-btcdjmfp 288 45 lethal lethal JJ cord-006824-btcdjmfp 288 46 preparative preparative JJ cord-006824-btcdjmfp 288 47 regimens regimen NNS cord-006824-btcdjmfp 288 48 [ [ -LRB- cord-006824-btcdjmfp 288 49 19 19 CD cord-006824-btcdjmfp 288 50 , , , cord-006824-btcdjmfp 288 51 46 46 CD cord-006824-btcdjmfp 288 52 ] ] -RRB- cord-006824-btcdjmfp 288 53 . . . cord-006824-btcdjmfp 289 1 The the DT cord-006824-btcdjmfp 289 2 use use NN cord-006824-btcdjmfp 289 3 of of IN cord-006824-btcdjmfp 289 4 these these DT cord-006824-btcdjmfp 289 5 regimens regimen NNS cord-006824-btcdjmfp 289 6 is be VBZ cord-006824-btcdjmfp 289 7 not not RB cord-006824-btcdjmfp 289 8 feasible feasible JJ cord-006824-btcdjmfp 289 9 in in IN cord-006824-btcdjmfp 289 10 more more RBR cord-006824-btcdjmfp 289 11 aggressive aggressive JJ cord-006824-btcdjmfp 289 12 forms form NNS cord-006824-btcdjmfp 289 13 of of IN cord-006824-btcdjmfp 289 14 storage storage NN cord-006824-btcdjmfp 289 15 diseases disease NNS cord-006824-btcdjmfp 289 16 . . . cord-006824-btcdjmfp 290 1 Insertion insertion NN cord-006824-btcdjmfp 290 2 of of IN cord-006824-btcdjmfp 290 3 genes gene NNS cord-006824-btcdjmfp 290 4 for for IN cord-006824-btcdjmfp 290 5 specific specific JJ cord-006824-btcdjmfp 290 6 lysosomal lysosomal JJ cord-006824-btcdjmfp 290 7 hydrolases hydrolase NNS cord-006824-btcdjmfp 290 8 or or CC cord-006824-btcdjmfp 290 9 for for IN cord-006824-btcdjmfp 290 10 the the DT cord-006824-btcdjmfp 290 11 ALD ALD NNP cord-006824-btcdjmfp 290 12 protein protein NN cord-006824-btcdjmfp 290 13 into into IN cord-006824-btcdjmfp 290 14 autologous autologous JJ cord-006824-btcdjmfp 290 15 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 290 16 stem stem NN cord-006824-btcdjmfp 290 17 cells cell NNS cord-006824-btcdjmfp 290 18 ( ( -LRB- cord-006824-btcdjmfp 290 19 HSCs hscs NN cord-006824-btcdjmfp 290 20 ) ) -RRB- cord-006824-btcdjmfp 290 21 and and CC cord-006824-btcdjmfp 290 22 transplantation transplantation NN cord-006824-btcdjmfp 290 23 of of IN cord-006824-btcdjmfp 290 24 these these DT cord-006824-btcdjmfp 290 25 cells cell NNS cord-006824-btcdjmfp 290 26 is be VBZ cord-006824-btcdjmfp 290 27 theoretically theoretically RB cord-006824-btcdjmfp 290 28 very very RB cord-006824-btcdjmfp 290 29 attractive attractive JJ cord-006824-btcdjmfp 290 30 but but CC cord-006824-btcdjmfp 290 31 remains remain VBZ cord-006824-btcdjmfp 290 32 at at IN cord-006824-btcdjmfp 290 33 the the DT cord-006824-btcdjmfp 290 34 level level NN cord-006824-btcdjmfp 290 35 of of IN cord-006824-btcdjmfp 290 36 preclinical preclinical JJ cord-006824-btcdjmfp 290 37 investigation investigation NN cord-006824-btcdjmfp 290 38 at at IN cord-006824-btcdjmfp 290 39 this this DT cord-006824-btcdjmfp 290 40 time time NN cord-006824-btcdjmfp 290 41 because because IN cord-006824-btcdjmfp 290 42 of of IN cord-006824-btcdjmfp 290 43 ongoing ongoing JJ cord-006824-btcdjmfp 290 44 challenges challenge NNS cord-006824-btcdjmfp 290 45 such such JJ cord-006824-btcdjmfp 290 46 as as IN cord-006824-btcdjmfp 290 47 efficient efficient JJ cord-006824-btcdjmfp 290 48 introduction introduction NN cord-006824-btcdjmfp 290 49 and and CC cord-006824-btcdjmfp 290 50 integration integration NN cord-006824-btcdjmfp 290 51 of of IN cord-006824-btcdjmfp 290 52 the the DT cord-006824-btcdjmfp 290 53 exogenous exogenous JJ cord-006824-btcdjmfp 290 54 gene gene NN cord-006824-btcdjmfp 290 55 in in IN cord-006824-btcdjmfp 290 56 truly truly RB cord-006824-btcdjmfp 290 57 primitive primitive JJ cord-006824-btcdjmfp 290 58 HSCs hscs NN cord-006824-btcdjmfp 290 59 and and CC cord-006824-btcdjmfp 290 60 sustained sustain VBN cord-006824-btcdjmfp 290 61 , , , cord-006824-btcdjmfp 290 62 consistent consistent JJ cord-006824-btcdjmfp 290 63 high high JJ cord-006824-btcdjmfp 290 64 - - HYPH cord-006824-btcdjmfp 290 65 level level NN cord-006824-btcdjmfp 290 66 expression expression NN cord-006824-btcdjmfp 290 67 of of IN cord-006824-btcdjmfp 290 68 the the DT cord-006824-btcdjmfp 290 69 hydrolase hydrolase NN cord-006824-btcdjmfp 290 70 in in IN cord-006824-btcdjmfp 290 71 these these DT cord-006824-btcdjmfp 290 72 cells cell NNS cord-006824-btcdjmfp 290 73 and and CC cord-006824-btcdjmfp 290 74 their -PRON- PRP$ cord-006824-btcdjmfp 290 75 progeny progeny NN cord-006824-btcdjmfp 290 76 [ [ -LRB- cord-006824-btcdjmfp 290 77 41 41 CD cord-006824-btcdjmfp 290 78 ] ] -RRB- cord-006824-btcdjmfp 290 79 . . . cord-006824-btcdjmfp 291 1 A a DT cord-006824-btcdjmfp 291 2 potentially potentially RB cord-006824-btcdjmfp 291 3 exciting exciting JJ cord-006824-btcdjmfp 291 4 approach approach NN cord-006824-btcdjmfp 291 5 for for IN cord-006824-btcdjmfp 291 6 storage storage NN cord-006824-btcdjmfp 291 7 diseases disease NNS cord-006824-btcdjmfp 291 8 with with IN cord-006824-btcdjmfp 291 9 skeletal skeletal JJ cord-006824-btcdjmfp 291 10 manifestations manifestation NNS cord-006824-btcdjmfp 291 11 ( ( -LRB- cord-006824-btcdjmfp 291 12 dysostosis dysostosis NNP cord-006824-btcdjmfp 291 13 multiplex multiplex NN cord-006824-btcdjmfp 291 14 ) ) -RRB- cord-006824-btcdjmfp 291 15 is be VBZ cord-006824-btcdjmfp 291 16 the the DT cord-006824-btcdjmfp 291 17 co co NN cord-006824-btcdjmfp 291 18 - - NN cord-006824-btcdjmfp 291 19 transplantation transplantation NN cord-006824-btcdjmfp 291 20 of of IN cord-006824-btcdjmfp 291 21 mesenchymal mesenchymal JJ cord-006824-btcdjmfp 291 22 stem stem NN cord-006824-btcdjmfp 291 23 cells cell NNS cord-006824-btcdjmfp 291 24 ( ( -LRB- cord-006824-btcdjmfp 291 25 MSCs msc NNS cord-006824-btcdjmfp 291 26 ) ) -RRB- cord-006824-btcdjmfp 291 27 , , , cord-006824-btcdjmfp 291 28 which which WDT cord-006824-btcdjmfp 291 29 may may MD cord-006824-btcdjmfp 291 30 differentiate differentiate VB cord-006824-btcdjmfp 291 31 into into IN cord-006824-btcdjmfp 291 32 chondrocytes chondrocyte NNS cord-006824-btcdjmfp 291 33 and and CC cord-006824-btcdjmfp 291 34 osteoblasts osteoblast NNS cord-006824-btcdjmfp 291 35 [ [ -LRB- cord-006824-btcdjmfp 291 36 33 33 CD cord-006824-btcdjmfp 291 37 , , , cord-006824-btcdjmfp 291 38 39 39 CD cord-006824-btcdjmfp 291 39 ] ] -RRB- cord-006824-btcdjmfp 291 40 . . . cord-006824-btcdjmfp 292 1 Although although IN cord-006824-btcdjmfp 292 2 clearly clearly RB cord-006824-btcdjmfp 292 3 not not RB cord-006824-btcdjmfp 292 4 a a DT cord-006824-btcdjmfp 292 5 clinical clinical JJ cord-006824-btcdjmfp 292 6 therapeutic therapeutic JJ cord-006824-btcdjmfp 292 7 option option NN cord-006824-btcdjmfp 292 8 at at IN cord-006824-btcdjmfp 292 9 this this DT cord-006824-btcdjmfp 292 10 time time NN cord-006824-btcdjmfp 292 11 , , , cord-006824-btcdjmfp 292 12 intracerebral intracerebral JJ cord-006824-btcdjmfp 292 13 injection injection NN cord-006824-btcdjmfp 292 14 of of IN cord-006824-btcdjmfp 292 15 MSCs msc NNS cord-006824-btcdjmfp 292 16 may may MD cord-006824-btcdjmfp 292 17 favorably favorably RB cord-006824-btcdjmfp 292 18 affect affect VB cord-006824-btcdjmfp 292 19 the the DT cord-006824-btcdjmfp 292 20 neuropathological neuropathological JJ cord-006824-btcdjmfp 292 21 and and CC cord-006824-btcdjmfp 292 22 biochemical biochemical JJ cord-006824-btcdjmfp 292 23 abnormalities abnormality NNS cord-006824-btcdjmfp 292 24 in in IN cord-006824-btcdjmfp 292 25 a a DT cord-006824-btcdjmfp 292 26 murine murine JJ cord-006824-btcdjmfp 292 27 model model NN cord-006824-btcdjmfp 292 28 of of IN cord-006824-btcdjmfp 292 29 acid acid NN cord-006824-btcdjmfp 292 30 sphingomyelinase sphingomyelinase NN cord-006824-btcdjmfp 292 31 deficiency deficiency NN cord-006824-btcdjmfp 292 32 ( ( -LRB- cord-006824-btcdjmfp 292 33 Niemann Niemann NNP cord-006824-btcdjmfp 292 34 - - HYPH cord-006824-btcdjmfp 292 35 Pick Pick NNP cord-006824-btcdjmfp 292 36 disease disease NN cord-006824-btcdjmfp 292 37 types type NNS cord-006824-btcdjmfp 292 38 A a NN cord-006824-btcdjmfp 292 39 and and CC cord-006824-btcdjmfp 292 40 B b NN cord-006824-btcdjmfp 292 41 ) ) -RRB- cord-006824-btcdjmfp 292 42 [ [ -LRB- cord-006824-btcdjmfp 292 43 16 16 CD cord-006824-btcdjmfp 292 44 ] ] -RRB- cord-006824-btcdjmfp 292 45 . . . cord-006824-btcdjmfp 293 1 Clinical clinical JJ cord-006824-btcdjmfp 293 2 experience experience NN cord-006824-btcdjmfp 293 3 for for IN cord-006824-btcdjmfp 293 4 more more JJR cord-006824-btcdjmfp 293 5 than than IN cord-006824-btcdjmfp 293 6 two two CD cord-006824-btcdjmfp 293 7 decades decade NNS cord-006824-btcdjmfp 293 8 has have VBZ cord-006824-btcdjmfp 293 9 shown show VBN cord-006824-btcdjmfp 293 10 that that IN cord-006824-btcdjmfp 293 11 allogeneic allogeneic NN cord-006824-btcdjmfp 293 12 HCT hct NN cord-006824-btcdjmfp 293 13 may may MD cord-006824-btcdjmfp 293 14 benefit benefit VB cord-006824-btcdjmfp 293 15 some some DT cord-006824-btcdjmfp 293 16 but but CC cord-006824-btcdjmfp 293 17 not not RB cord-006824-btcdjmfp 293 18 all all DT cord-006824-btcdjmfp 293 19 patients patient NNS cord-006824-btcdjmfp 293 20 with with IN cord-006824-btcdjmfp 293 21 inherited inherit VBN cord-006824-btcdjmfp 293 22 metabolic metabolic JJ cord-006824-btcdjmfp 293 23 diseases disease NNS cord-006824-btcdjmfp 293 24 . . . cord-006824-btcdjmfp 294 1 The the DT cord-006824-btcdjmfp 294 2 HCT HCT NNP cord-006824-btcdjmfp 294 3 procedure procedure NN cord-006824-btcdjmfp 294 4 is be VBZ cord-006824-btcdjmfp 294 5 most most RBS cord-006824-btcdjmfp 294 6 effective effective JJ cord-006824-btcdjmfp 294 7 in in IN cord-006824-btcdjmfp 294 8 presymptomatic presymptomatic JJ cord-006824-btcdjmfp 294 9 patients patient NNS cord-006824-btcdjmfp 294 10 and and CC cord-006824-btcdjmfp 294 11 those those DT cord-006824-btcdjmfp 294 12 with with IN cord-006824-btcdjmfp 294 13 indolent indolent JJ cord-006824-btcdjmfp 294 14 forms form NNS cord-006824-btcdjmfp 294 15 of of IN cord-006824-btcdjmfp 294 16 storage storage NN cord-006824-btcdjmfp 294 17 diseases disease NNS cord-006824-btcdjmfp 294 18 but but CC cord-006824-btcdjmfp 294 19 is be VBZ cord-006824-btcdjmfp 294 20 ineffective ineffective JJ cord-006824-btcdjmfp 294 21 in in IN cord-006824-btcdjmfp 294 22 those those DT cord-006824-btcdjmfp 294 23 with with IN cord-006824-btcdjmfp 294 24 overt overt JJ cord-006824-btcdjmfp 294 25 neurological neurological JJ cord-006824-btcdjmfp 294 26 symptoms symptom NNS cord-006824-btcdjmfp 294 27 or or CC cord-006824-btcdjmfp 294 28 aggressive aggressive JJ cord-006824-btcdjmfp 294 29 neonatal neonatal JJ cord-006824-btcdjmfp 294 30 or or CC cord-006824-btcdjmfp 294 31 infantile infantile JJ cord-006824-btcdjmfp 294 32 forms form NNS cord-006824-btcdjmfp 294 33 . . . cord-006824-btcdjmfp 295 1 HCT HCT NNP cord-006824-btcdjmfp 295 2 alone alone RB cord-006824-btcdjmfp 295 3 does do VBZ cord-006824-btcdjmfp 295 4 not not RB cord-006824-btcdjmfp 295 5 correct correct VB cord-006824-btcdjmfp 295 6 skeletal skeletal JJ cord-006824-btcdjmfp 295 7 dysplasia dysplasia NN cord-006824-btcdjmfp 295 8 in in IN cord-006824-btcdjmfp 295 9 MPSs mpss NN cord-006824-btcdjmfp 295 10 and and CC cord-006824-btcdjmfp 295 11 may may MD cord-006824-btcdjmfp 295 12 not not RB cord-006824-btcdjmfp 295 13 prevent prevent VB cord-006824-btcdjmfp 295 14 development development NN cord-006824-btcdjmfp 295 15 or or CC cord-006824-btcdjmfp 295 16 progression progression NN cord-006824-btcdjmfp 295 17 of of IN cord-006824-btcdjmfp 295 18 the the DT cord-006824-btcdjmfp 295 19 peripheral peripheral JJ cord-006824-btcdjmfp 295 20 neuropathy neuropathy NN cord-006824-btcdjmfp 295 21 in in IN cord-006824-btcdjmfp 295 22 sphingolipidoses sphingolipidose NNS cord-006824-btcdjmfp 295 23 and and CC cord-006824-btcdjmfp 295 24 ALD ALD NNP cord-006824-btcdjmfp 295 25 . . . cord-006824-btcdjmfp 296 1 Decisions decision NNS cord-006824-btcdjmfp 296 2 regarding regard VBG cord-006824-btcdjmfp 296 3 HCT hct NN cord-006824-btcdjmfp 296 4 in in IN cord-006824-btcdjmfp 296 5 patients patient NNS cord-006824-btcdjmfp 296 6 with with IN cord-006824-btcdjmfp 296 7 storage storage NN cord-006824-btcdjmfp 296 8 diseases disease NNS cord-006824-btcdjmfp 296 9 should should MD cord-006824-btcdjmfp 296 10 be be VB cord-006824-btcdjmfp 296 11 made make VBN cord-006824-btcdjmfp 296 12 by by IN cord-006824-btcdjmfp 296 13 investigators investigator NNS cord-006824-btcdjmfp 296 14 knowledgeable knowledgeable JJ cord-006824-btcdjmfp 296 15 about about IN cord-006824-btcdjmfp 296 16 these these DT cord-006824-btcdjmfp 296 17 diseases disease NNS cord-006824-btcdjmfp 296 18 , , , cord-006824-btcdjmfp 296 19 with with IN cord-006824-btcdjmfp 296 20 judicious judicious JJ cord-006824-btcdjmfp 296 21 use use NN cord-006824-btcdjmfp 296 22 of of IN cord-006824-btcdjmfp 296 23 laboratory laboratory NN cord-006824-btcdjmfp 296 24 and and CC cord-006824-btcdjmfp 296 25 clinical clinical JJ cord-006824-btcdjmfp 296 26 resources resource NNS cord-006824-btcdjmfp 296 27 necessary necessary JJ cord-006824-btcdjmfp 296 28 to to TO cord-006824-btcdjmfp 296 29 reach reach VB cord-006824-btcdjmfp 296 30 the the DT cord-006824-btcdjmfp 296 31 best good JJS cord-006824-btcdjmfp 296 32 therapeutic therapeutic JJ cord-006824-btcdjmfp 296 33 decision decision NN cord-006824-btcdjmfp 296 34 for for IN cord-006824-btcdjmfp 296 35 the the DT cord-006824-btcdjmfp 296 36 individual individual JJ cord-006824-btcdjmfp 296 37 patient patient NN cord-006824-btcdjmfp 296 38 . . . cord-006824-btcdjmfp 297 1 Treatment treatment NN cord-006824-btcdjmfp 297 2 of of IN cord-006824-btcdjmfp 297 3 malignant malignant JJ cord-006824-btcdjmfp 297 4 lymphoma lymphoma NN cord-006824-btcdjmfp 297 5 in in IN cord-006824-btcdjmfp 297 6 100 100 CD cord-006824-btcdjmfp 297 7 patients patient NNS cord-006824-btcdjmfp 297 8 with with IN cord-006824-btcdjmfp 297 9 chemotherapy chemotherapy NN cord-006824-btcdjmfp 297 10 , , , cord-006824-btcdjmfp 297 11 total total JJ cord-006824-btcdjmfp 297 12 body body NN cord-006824-btcdjmfp 297 13 irradiation irradiation NN cord-006824-btcdjmfp 297 14 , , , cord-006824-btcdjmfp 297 15 and and CC cord-006824-btcdjmfp 297 16 marrow marrow NN cord-006824-btcdjmfp 297 17 transplantation transplantation NN cord-006824-btcdjmfp 298 1 Allogeneic allogeneic IN cord-006824-btcdjmfp 298 2 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 298 3 cell cell NN cord-006824-btcdjmfp 298 4 transplantation transplantation NN cord-006824-btcdjmfp 298 5 for for IN cord-006824-btcdjmfp 298 6 chronic chronic JJ cord-006824-btcdjmfp 298 7 lymphocytic lymphocytic JJ cord-006824-btcdjmfp 298 8 leukemia leukemia NN cord-006824-btcdjmfp 298 9 and and CC cord-006824-btcdjmfp 298 10 lymphoma lymphoma NN cord-006824-btcdjmfp 298 11 High high JJ cord-006824-btcdjmfp 298 12 - - HYPH cord-006824-btcdjmfp 298 13 resolution resolution NN cord-006824-btcdjmfp 298 14 computed compute VBN cord-006824-btcdjmfp 298 15 tomography tomography NN cord-006824-btcdjmfp 298 16 of of IN cord-006824-btcdjmfp 298 17 bronchiolitis bronchiolitis NNP cord-006824-btcdjmfp 298 18 obliterans obliterans NNP cord-006824-btcdjmfp 298 19 syndrome syndrome NN cord-006824-btcdjmfp 298 20 after after IN cord-006824-btcdjmfp 298 21 bone bone NN cord-006824-btcdjmfp 298 22 marrow marrow NN cord-006824-btcdjmfp 298 23 transplantation transplantation NN cord-006824-btcdjmfp 298 24 Idiopathic idiopathic JJ cord-006824-btcdjmfp 298 25 pulmonary pulmonary JJ cord-006824-btcdjmfp 298 26 fibrosis fibrosis NN cord-006824-btcdjmfp 298 27 in in IN cord-006824-btcdjmfp 298 28 infants infant NNS cord-006824-btcdjmfp 298 29 Late late JJ cord-006824-btcdjmfp 298 30 - - HYPH cord-006824-btcdjmfp 298 31 onset onset JJ cord-006824-btcdjmfp 298 32 noninfectious noninfectious JJ cord-006824-btcdjmfp 298 33 pulmonary pulmonary JJ cord-006824-btcdjmfp 298 34 complications complication NNS cord-006824-btcdjmfp 298 35 after after IN cord-006824-btcdjmfp 298 36 allogeneic allogeneic NN cord-006824-btcdjmfp 298 37 bone bone NN cord-006824-btcdjmfp 298 38 marrow marrow NN cord-006824-btcdjmfp 298 39 transplantation transplantation NN cord-006824-btcdjmfp 299 1 Increasing increase VBG cord-006824-btcdjmfp 299 2 dose dose NN cord-006824-btcdjmfp 299 3 of of IN cord-006824-btcdjmfp 299 4 methylprednisolone methylprednisolone JJ cord-006824-btcdjmfp 299 5 pulse pulse NN cord-006824-btcdjmfp 299 6 therapy therapy NN cord-006824-btcdjmfp 299 7 treats treat VBZ cord-006824-btcdjmfp 299 8 desquamative desquamative JJ cord-006824-btcdjmfp 299 9 intersitial intersitial JJ cord-006824-btcdjmfp 299 10 pneumonitis pneumonitis NN cord-006824-btcdjmfp 299 11 in in IN cord-006824-btcdjmfp 299 12 a a DT cord-006824-btcdjmfp 299 13 child child NN cord-006824-btcdjmfp 299 14 Post post NN cord-006824-btcdjmfp 299 15 - - JJ cord-006824-btcdjmfp 299 16 transplant transplant JJ cord-006824-btcdjmfp 299 17 obstructive obstructive JJ cord-006824-btcdjmfp 299 18 lung lung NN cord-006824-btcdjmfp 299 19 disease disease NN cord-006824-btcdjmfp 299 20 ( ( -LRB- cord-006824-btcdjmfp 299 21 " " `` cord-006824-btcdjmfp 299 22 bronchiolitis bronchiolitis NNP cord-006824-btcdjmfp 299 23 obliterans obliterans NNP cord-006824-btcdjmfp 299 24 " " '' cord-006824-btcdjmfp 299 25 ) ) -RRB- cord-006824-btcdjmfp 299 26 : : : cord-006824-btcdjmfp 299 27 a a DT cord-006824-btcdjmfp 299 28 clinical clinical JJ cord-006824-btcdjmfp 299 29 comparative comparative JJ cord-006824-btcdjmfp 299 30 study study NN cord-006824-btcdjmfp 299 31 of of IN cord-006824-btcdjmfp 299 32 bone bone NN cord-006824-btcdjmfp 299 33 marrow marrow NN cord-006824-btcdjmfp 299 34 and and CC cord-006824-btcdjmfp 299 35 lung lung NN cord-006824-btcdjmfp 299 36 transplant transplant NN cord-006824-btcdjmfp 299 37 patients patient NNS cord-006824-btcdjmfp 299 38 Clinical clinical JJ cord-006824-btcdjmfp 299 39 strategies strategy NNS cord-006824-btcdjmfp 299 40 for for IN cord-006824-btcdjmfp 299 41 the the DT cord-006824-btcdjmfp 299 42 management management NN cord-006824-btcdjmfp 299 43 of of IN cord-006824-btcdjmfp 299 44 cytomegalovirus cytomegalovirus JJ cord-006824-btcdjmfp 299 45 infection infection NN cord-006824-btcdjmfp 299 46 and and CC cord-006824-btcdjmfp 299 47 disease disease NN cord-006824-btcdjmfp 299 48 in in IN cord-006824-btcdjmfp 299 49 allogeneic allogeneic NN cord-006824-btcdjmfp 299 50 bone bone NN cord-006824-btcdjmfp 299 51 marrow marrow NN cord-006824-btcdjmfp 299 52 transplant transplant NN cord-006824-btcdjmfp 300 1 The the DT cord-006824-btcdjmfp 300 2 lung lung NN cord-006824-btcdjmfp 300 3 as as IN cord-006824-btcdjmfp 300 4 a a DT cord-006824-btcdjmfp 300 5 critical critical JJ cord-006824-btcdjmfp 300 6 organ organ NN cord-006824-btcdjmfp 300 7 in in IN cord-006824-btcdjmfp 300 8 marrow marrow NN cord-006824-btcdjmfp 300 9 transplantation transplantation NN cord-006824-btcdjmfp 301 1 The the DT cord-006824-btcdjmfp 301 2 effects effect NNS cord-006824-btcdjmfp 301 3 of of IN cord-006824-btcdjmfp 301 4 bone bone NN cord-006824-btcdjmfp 301 5 marrow marrow NN cord-006824-btcdjmfp 301 6 transplantation transplantation NN cord-006824-btcdjmfp 301 7 on on IN cord-006824-btcdjmfp 301 8 pulmonary pulmonary JJ cord-006824-btcdjmfp 301 9 function function NN cord-006824-btcdjmfp 301 10 in in IN cord-006824-btcdjmfp 301 11 children child NNS cord-006824-btcdjmfp 301 12 Fatal fatal JJ cord-006824-btcdjmfp 301 13 airway airway NN cord-006824-btcdjmfp 301 14 disease disease NN cord-006824-btcdjmfp 301 15 in in IN cord-006824-btcdjmfp 301 16 an an DT cord-006824-btcdjmfp 301 17 adult adult NN cord-006824-btcdjmfp 301 18 with with IN cord-006824-btcdjmfp 301 19 chronic chronic JJ cord-006824-btcdjmfp 301 20 graft graft NN cord-006824-btcdjmfp 301 21 - - HYPH cord-006824-btcdjmfp 301 22 versus versus IN cord-006824-btcdjmfp 301 23 - - HYPH cord-006824-btcdjmfp 301 24 host host NN cord-006824-btcdjmfp 301 25 disease disease NN cord-006824-btcdjmfp 301 26 Obstructive obstructive JJ cord-006824-btcdjmfp 301 27 lung lung NN cord-006824-btcdjmfp 301 28 disease disease NN cord-006824-btcdjmfp 301 29 in in IN cord-006824-btcdjmfp 301 30 children child NNS cord-006824-btcdjmfp 301 31 after after IN cord-006824-btcdjmfp 301 32 allogeneic allogeneic NN cord-006824-btcdjmfp 301 33 bone bone NN cord-006824-btcdjmfp 301 34 marrow marrow NN cord-006824-btcdjmfp 301 35 transplantation transplantation NN cord-006824-btcdjmfp 301 36 : : : cord-006824-btcdjmfp 301 37 evaluation evaluation NN cord-006824-btcdjmfp 301 38 with with IN cord-006824-btcdjmfp 301 39 high high JJ cord-006824-btcdjmfp 301 40 - - HYPH cord-006824-btcdjmfp 301 41 resolution resolution NN cord-006824-btcdjmfp 301 42 CT CT NNP cord-006824-btcdjmfp 301 43 Obstructive obstructive JJ cord-006824-btcdjmfp 301 44 lung lung NN cord-006824-btcdjmfp 301 45 disease disease NN cord-006824-btcdjmfp 301 46 in in IN cord-006824-btcdjmfp 301 47 children child NNS cord-006824-btcdjmfp 301 48 after after IN cord-006824-btcdjmfp 301 49 allogeneic allogeneic NN cord-006824-btcdjmfp 301 50 bone bone NN cord-006824-btcdjmfp 301 51 marrow marrow NN cord-006824-btcdjmfp 301 52 transplantation transplantation NN cord-006824-btcdjmfp 302 1 The the DT cord-006824-btcdjmfp 302 2 laboratory laboratory NN cord-006824-btcdjmfp 302 3 evaluation evaluation NN cord-006824-btcdjmfp 302 4 of of IN cord-006824-btcdjmfp 302 5 opportunistic opportunistic JJ cord-006824-btcdjmfp 302 6 pulmonary pulmonary JJ cord-006824-btcdjmfp 302 7 infections infection NNS cord-006824-btcdjmfp 302 8 Pulmonary pulmonary JJ cord-006824-btcdjmfp 302 9 complications complication NNS cord-006824-btcdjmfp 302 10 of of IN cord-006824-btcdjmfp 302 11 bone bone NN cord-006824-btcdjmfp 302 12 marrow marrow NN cord-006824-btcdjmfp 302 13 transplantation transplantation NN cord-006824-btcdjmfp 302 14 Lymphocytic lymphocytic JJ cord-006824-btcdjmfp 302 15 pneumonitis pneumonitis NN cord-006824-btcdjmfp 302 16 following follow VBG cord-006824-btcdjmfp 302 17 bone bone NN cord-006824-btcdjmfp 302 18 marrow marrow NN cord-006824-btcdjmfp 302 19 transplantation transplantation NN cord-006824-btcdjmfp 302 20 in in IN cord-006824-btcdjmfp 302 21 severe severe JJ cord-006824-btcdjmfp 302 22 combined combine VBN cord-006824-btcdjmfp 302 23 immunodefiency immunodefiency NN cord-006824-btcdjmfp 302 24 Immunmodulatory Immunmodulatory NNP cord-006824-btcdjmfp 302 25 and and CC cord-006824-btcdjmfp 302 26 antimicrobial antimicrobial JJ cord-006824-btcdjmfp 302 27 efficacy efficacy NN cord-006824-btcdjmfp 302 28 of of IN cord-006824-btcdjmfp 302 29 intravenous intravenous JJ cord-006824-btcdjmfp 302 30 immunoglobulin immunoglobulin NN cord-006824-btcdjmfp 302 31 in in IN cord-006824-btcdjmfp 302 32 bone bone NN cord-006824-btcdjmfp 302 33 marrow marrow NN cord-006824-btcdjmfp 302 34 transplantation transplantation NN cord-006824-btcdjmfp 302 35 Transplantation transplantation NN cord-006824-btcdjmfp 302 36 of of IN cord-006824-btcdjmfp 302 37 a a DT cord-006824-btcdjmfp 302 38 lobe lobe NN cord-006824-btcdjmfp 302 39 of of IN cord-006824-btcdjmfp 302 40 lung lung NN cord-006824-btcdjmfp 302 41 from from IN cord-006824-btcdjmfp 302 42 mother mother NN cord-006824-btcdjmfp 302 43 to to IN cord-006824-btcdjmfp 302 44 child child NN cord-006824-btcdjmfp 302 45 following follow VBG cord-006824-btcdjmfp 302 46 previous previous JJ cord-006824-btcdjmfp 302 47 transplantation transplantation NN cord-006824-btcdjmfp 302 48 with with IN cord-006824-btcdjmfp 302 49 maternal maternal JJ cord-006824-btcdjmfp 302 50 bone bone NN cord-006824-btcdjmfp 302 51 marrow marrow NN cord-006824-btcdjmfp 302 52 Bronchiolitis bronchiolitis NN cord-006824-btcdjmfp 302 53 obliterans obliterans NN cord-006824-btcdjmfp 302 54 organizing organize VBG cord-006824-btcdjmfp 302 55 pneumonia pneumonia NN cord-006824-btcdjmfp 302 56 as as IN cord-006824-btcdjmfp 302 57 a a DT cord-006824-btcdjmfp 302 58 complication complication NN cord-006824-btcdjmfp 302 59 of of IN cord-006824-btcdjmfp 302 60 allogeneic allogeneic NN cord-006824-btcdjmfp 302 61 bone bone NN cord-006824-btcdjmfp 302 62 marrow marrow NN cord-006824-btcdjmfp 302 63 transplantation transplantation NN cord-006824-btcdjmfp 302 64 Parainfluenza Parainfluenza NNP cord-006824-btcdjmfp 302 65 virus virus NN cord-006824-btcdjmfp 302 66 respiratory respiratory JJ cord-006824-btcdjmfp 302 67 infection infection NN cord-006824-btcdjmfp 302 68 after after IN cord-006824-btcdjmfp 302 69 bone bone NN cord-006824-btcdjmfp 302 70 marrow marrow NN cord-006824-btcdjmfp 302 71 transplantation transplantation NN cord-006824-btcdjmfp 302 72 Alveolar Alveolar NNP cord-006824-btcdjmfp 302 73 macrophage macrophage NN cord-006824-btcdjmfp 302 74 activity activity NN cord-006824-btcdjmfp 302 75 and and CC cord-006824-btcdjmfp 302 76 the the DT cord-006824-btcdjmfp 302 77 pulmonary pulmonary JJ cord-006824-btcdjmfp 302 78 complications complication NNS cord-006824-btcdjmfp 302 79 of of IN cord-006824-btcdjmfp 302 80 haematopoetic haematopoetic JJ cord-006824-btcdjmfp 302 81 stem stem NN cord-006824-btcdjmfp 302 82 cell cell NN cord-006824-btcdjmfp 302 83 transplantation transplantation NN cord-006824-btcdjmfp 302 84 Interstitial interstitial JJ cord-006824-btcdjmfp 302 85 pneumonitis pneumonitis NN cord-006824-btcdjmfp 302 86 after after IN cord-006824-btcdjmfp 302 87 allogenic allogenic JJ cord-006824-btcdjmfp 302 88 bone bone NN cord-006824-btcdjmfp 302 89 marrow marrow NN cord-006824-btcdjmfp 302 90 transplantation transplantation NN cord-006824-btcdjmfp 302 91 X x NN cord-006824-btcdjmfp 302 92 - - HYPH cord-006824-btcdjmfp 302 93 linked link VBN cord-006824-btcdjmfp 302 94 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 302 95 Lysosomal Lysosomal NNP cord-006824-btcdjmfp 302 96 storage storage NN cord-006824-btcdjmfp 302 97 diseases disease NNS cord-006824-btcdjmfp 302 98 : : : cord-006824-btcdjmfp 302 99 mechanisms mechanism NNS cord-006824-btcdjmfp 302 100 of of IN cord-006824-btcdjmfp 302 101 enzyme enzyme NN cord-006824-btcdjmfp 302 102 replacement replacement NN cord-006824-btcdjmfp 302 103 therapy therapy NN cord-006824-btcdjmfp 302 104 Long long JJ cord-006824-btcdjmfp 302 105 - - HYPH cord-006824-btcdjmfp 302 106 term term NN cord-006824-btcdjmfp 302 107 effects effect NNS cord-006824-btcdjmfp 302 108 of of IN cord-006824-btcdjmfp 302 109 bone bone NN cord-006824-btcdjmfp 302 110 marrow marrow NN cord-006824-btcdjmfp 302 111 transplantation transplantation NN cord-006824-btcdjmfp 302 112 in in IN cord-006824-btcdjmfp 302 113 dogs dog NNS cord-006824-btcdjmfp 302 114 with with IN cord-006824-btcdjmfp 302 115 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 303 1 I -PRON- PRP cord-006824-btcdjmfp 304 1 In in IN cord-006824-btcdjmfp 304 2 utero utero NN cord-006824-btcdjmfp 304 3 transplantation transplantation NN cord-006824-btcdjmfp 304 4 of of IN cord-006824-btcdjmfp 304 5 fetal fetal JJ cord-006824-btcdjmfp 304 6 liver liver NN cord-006824-btcdjmfp 304 7 cells cell NNS cord-006824-btcdjmfp 304 8 in in IN cord-006824-btcdjmfp 304 9 the the DT cord-006824-btcdjmfp 304 10 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 304 11 type type NN cord-006824-btcdjmfp 304 12 VII VII NNP cord-006824-btcdjmfp 304 13 mouse mouse NN cord-006824-btcdjmfp 304 14 results result NNS cord-006824-btcdjmfp 304 15 in in IN cord-006824-btcdjmfp 304 16 low low JJ cord-006824-btcdjmfp 304 17 - - HYPH cord-006824-btcdjmfp 304 18 level level NN cord-006824-btcdjmfp 304 19 chimerism chimerism NN cord-006824-btcdjmfp 304 20 , , , cord-006824-btcdjmfp 304 21 but but CC cord-006824-btcdjmfp 304 22 overexpression overexpression NN cord-006824-btcdjmfp 304 23 of of IN cord-006824-btcdjmfp 304 24 beta beta NN cord-006824-btcdjmfp 304 25 - - HYPH cord-006824-btcdjmfp 304 26 glucuronidase glucuronidase NN cord-006824-btcdjmfp 304 27 can can MD cord-006824-btcdjmfp 304 28 delay delay VB cord-006824-btcdjmfp 304 29 onset onset NN cord-006824-btcdjmfp 304 30 of of IN cord-006824-btcdjmfp 304 31 clinical clinical JJ cord-006824-btcdjmfp 304 32 signs sign NNS cord-006824-btcdjmfp 304 33 Hematopoietic Hematopoietic NNP cord-006824-btcdjmfp 304 34 cells cell NNS cord-006824-btcdjmfp 304 35 differentiate differentiate VBP cord-006824-btcdjmfp 304 36 into into IN cord-006824-btcdjmfp 304 37 both both CC cord-006824-btcdjmfp 304 38 microglia microglia NNS cord-006824-btcdjmfp 304 39 and and CC cord-006824-btcdjmfp 304 40 macroglia macroglia NN cord-006824-btcdjmfp 304 41 in in IN cord-006824-btcdjmfp 304 42 the the DT cord-006824-btcdjmfp 304 43 brains brain NNS cord-006824-btcdjmfp 304 44 of of IN cord-006824-btcdjmfp 304 45 adult adult NN cord-006824-btcdjmfp 304 46 mice mouse NNS cord-006824-btcdjmfp 304 47 Lipogranulomatosis Lipogranulomatosis NNP cord-006824-btcdjmfp 304 48 . . . cord-006824-btcdjmfp 305 1 A a DT cord-006824-btcdjmfp 305 2 new new JJ cord-006824-btcdjmfp 305 3 lipoglycoprotein lipoglycoprotein JJ cord-006824-btcdjmfp 305 4 storage storage NN cord-006824-btcdjmfp 305 5 disease disease NN cord-006824-btcdjmfp 305 6 Bone Bone NNP cord-006824-btcdjmfp 305 7 - - HYPH cord-006824-btcdjmfp 305 8 marrow marrow NN cord-006824-btcdjmfp 305 9 transplantation transplantation NN cord-006824-btcdjmfp 305 10 in in IN cord-006824-btcdjmfp 305 11 Hurler Hurler NNP cord-006824-btcdjmfp 305 12 's 's POS cord-006824-btcdjmfp 305 13 syndrome syndrome NN cord-006824-btcdjmfp 305 14 . . . cord-006824-btcdjmfp 306 1 Effect effect NN cord-006824-btcdjmfp 306 2 on on IN cord-006824-btcdjmfp 306 3 skeletal skeletal JJ cord-006824-btcdjmfp 306 4 development development NN cord-006824-btcdjmfp 306 5 Constantopoulos Constantopoulos NNP cord-006824-btcdjmfp 306 6 GC GC NNP cord-006824-btcdjmfp 306 7 ( ( -LRB- cord-006824-btcdjmfp 306 8 1990 1990 CD cord-006824-btcdjmfp 306 9 ) ) -RRB- cord-006824-btcdjmfp 307 1 Cardiovascular cardiovascular JJ cord-006824-btcdjmfp 307 2 changes change NNS cord-006824-btcdjmfp 307 3 after after IN cord-006824-btcdjmfp 307 4 bone bone NN cord-006824-btcdjmfp 307 5 marrow marrow NN cord-006824-btcdjmfp 307 6 transplantation transplantation NN cord-006824-btcdjmfp 307 7 in in IN cord-006824-btcdjmfp 307 8 dogs dog NNS cord-006824-btcdjmfp 307 9 with with IN cord-006824-btcdjmfp 307 10 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 308 1 I -PRON- PRP cord-006824-btcdjmfp 308 2 Ocular ocular JJ cord-006824-btcdjmfp 308 3 abnormalities abnormality NNS cord-006824-btcdjmfp 308 4 in in IN cord-006824-btcdjmfp 308 5 the the DT cord-006824-btcdjmfp 308 6 mucopolysaccharidoses mucopolysaccharidose NNS cord-006824-btcdjmfp 308 7 after after IN cord-006824-btcdjmfp 308 8 bone bone NN cord-006824-btcdjmfp 308 9 marrow marrow NN cord-006824-btcdjmfp 308 10 transplantation transplantation NN cord-006824-btcdjmfp 308 11 . . . cord-006824-btcdjmfp 309 1 Longer long RBR cord-006824-btcdjmfp 309 2 follow follow VB cord-006824-btcdjmfp 309 3 - - HYPH cord-006824-btcdjmfp 309 4 up up RP cord-006824-btcdjmfp 309 5 Infantile infantile JJ cord-006824-btcdjmfp 309 6 globoid globoid JJ cord-006824-btcdjmfp 309 7 cell cell NN cord-006824-btcdjmfp 309 8 leucodystrophy leucodystrophy NN cord-006824-btcdjmfp 309 9 ( ( -LRB- cord-006824-btcdjmfp 309 10 Krabbe Krabbe NNP cord-006824-btcdjmfp 309 11 's 's POS cord-006824-btcdjmfp 309 12 disease disease NN cord-006824-btcdjmfp 309 13 ) ) -RRB- cord-006824-btcdjmfp 309 14 : : : cord-006824-btcdjmfp 309 15 a a DT cord-006824-btcdjmfp 309 16 clinical clinical JJ cord-006824-btcdjmfp 309 17 and and CC cord-006824-btcdjmfp 309 18 genetic genetic JJ cord-006824-btcdjmfp 309 19 study study NN cord-006824-btcdjmfp 309 20 of of IN cord-006824-btcdjmfp 309 21 32 32 CD cord-006824-btcdjmfp 309 22 Swedish swedish JJ cord-006824-btcdjmfp 309 23 cases case NNS cord-006824-btcdjmfp 309 24 1953 1953 CD cord-006824-btcdjmfp 309 25 - - SYM cord-006824-btcdjmfp 309 26 1967 1967 CD cord-006824-btcdjmfp 310 1 Migration migration NN cord-006824-btcdjmfp 310 2 of of IN cord-006824-btcdjmfp 310 3 hematogenous hematogenous NNP cord-006824-btcdjmfp 310 4 cells cell NNS cord-006824-btcdjmfp 310 5 through through IN cord-006824-btcdjmfp 310 6 the the DT cord-006824-btcdjmfp 310 7 blood blood NN cord-006824-btcdjmfp 310 8 - - HYPH cord-006824-btcdjmfp 310 9 brain brain NN cord-006824-btcdjmfp 310 10 barrier barrier NN cord-006824-btcdjmfp 310 11 and and CC cord-006824-btcdjmfp 310 12 the the DT cord-006824-btcdjmfp 310 13 initiation initiation NN cord-006824-btcdjmfp 310 14 of of IN cord-006824-btcdjmfp 310 15 CNS CNS NNP cord-006824-btcdjmfp 310 16 inflammation inflammation NN cord-006824-btcdjmfp 310 17 Perivascular Perivascular NNP cord-006824-btcdjmfp 310 18 microglial microglial JJ cord-006824-btcdjmfp 310 19 cells cell NNS cord-006824-btcdjmfp 310 20 of of IN cord-006824-btcdjmfp 310 21 the the DT cord-006824-btcdjmfp 310 22 CNS CNS NNP cord-006824-btcdjmfp 310 23 are be VBP cord-006824-btcdjmfp 310 24 bone bone NN cord-006824-btcdjmfp 310 25 marrow marrow NN cord-006824-btcdjmfp 310 26 - - HYPH cord-006824-btcdjmfp 310 27 derived derive VBN cord-006824-btcdjmfp 310 28 and and CC cord-006824-btcdjmfp 310 29 present present JJ cord-006824-btcdjmfp 310 30 antigen antigen NN cord-006824-btcdjmfp 310 31 in in IN cord-006824-btcdjmfp 310 32 vivo vivo NN cord-006824-btcdjmfp 310 33 Allogeneic allogeneic IN cord-006824-btcdjmfp 310 34 bone bone NN cord-006824-btcdjmfp 310 35 marrow marrow NN cord-006824-btcdjmfp 310 36 transplantation transplantation NN cord-006824-btcdjmfp 310 37 for for IN cord-006824-btcdjmfp 310 38 lysosomal lysosomal JJ cord-006824-btcdjmfp 310 39 storage storage NN cord-006824-btcdjmfp 310 40 diseases disease NNS cord-006824-btcdjmfp 310 41 . . . cord-006824-btcdjmfp 311 1 The the DT cord-006824-btcdjmfp 311 2 European European NNP cord-006824-btcdjmfp 311 3 Group Group NNP cord-006824-btcdjmfp 311 4 for for IN cord-006824-btcdjmfp 311 5 Bone Bone NNP cord-006824-btcdjmfp 311 6 Marrow Marrow NNP cord-006824-btcdjmfp 311 7 Transplantation Transplantation NNP cord-006824-btcdjmfp 311 8 Hematopoietic hematopoietic JJ cord-006824-btcdjmfp 311 9 cell cell NN cord-006824-btcdjmfp 311 10 transplantation transplantation NN cord-006824-btcdjmfp 311 11 in in IN cord-006824-btcdjmfp 311 12 murine murine JJ cord-006824-btcdjmfp 311 13 globoid globoid JJ cord-006824-btcdjmfp 311 14 cell cell NN cord-006824-btcdjmfp 311 15 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 311 16 ( ( -LRB- cord-006824-btcdjmfp 311 17 the the DT cord-006824-btcdjmfp 311 18 twitcher twitcher NN cord-006824-btcdjmfp 311 19 mouse mouse NN cord-006824-btcdjmfp 311 20 ) ) -RRB- cord-006824-btcdjmfp 311 21 : : : cord-006824-btcdjmfp 311 22 effects effect NNS cord-006824-btcdjmfp 311 23 on on IN cord-006824-btcdjmfp 311 24 levels level NNS cord-006824-btcdjmfp 311 25 of of IN cord-006824-btcdjmfp 311 26 galactosylceramidase galactosylceramidase NN cord-006824-btcdjmfp 311 27 , , , cord-006824-btcdjmfp 311 28 psychosine psychosine NN cord-006824-btcdjmfp 311 29 , , , cord-006824-btcdjmfp 311 30 and and CC cord-006824-btcdjmfp 311 31 galactocerebrosides galactocerebroside VBZ cord-006824-btcdjmfp 311 32 Progressive progressive JJ cord-006824-btcdjmfp 311 33 accumulation accumulation NN cord-006824-btcdjmfp 311 34 of of IN cord-006824-btcdjmfp 311 35 toxic toxic JJ cord-006824-btcdjmfp 311 36 metabolite metabolite NN cord-006824-btcdjmfp 311 37 in in IN cord-006824-btcdjmfp 311 38 a a DT cord-006824-btcdjmfp 311 39 genetic genetic JJ cord-006824-btcdjmfp 311 40 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 311 41 Intracerebral Intracerebral NNP cord-006824-btcdjmfp 311 42 transplantation transplantation NN cord-006824-btcdjmfp 311 43 of of IN cord-006824-btcdjmfp 311 44 mesenchymal mesenchymal JJ cord-006824-btcdjmfp 311 45 stem stem NN cord-006824-btcdjmfp 311 46 cells cell NNS cord-006824-btcdjmfp 311 47 into into IN cord-006824-btcdjmfp 311 48 acid acid NN cord-006824-btcdjmfp 311 49 sphingomyelinase sphingomyelinase NN cord-006824-btcdjmfp 311 50 - - HYPH cord-006824-btcdjmfp 311 51 deficient deficient JJ cord-006824-btcdjmfp 311 52 mice mice NN cord-006824-btcdjmfp 311 53 delays delay VBZ cord-006824-btcdjmfp 311 54 the the DT cord-006824-btcdjmfp 311 55 onset onset NN cord-006824-btcdjmfp 311 56 of of IN cord-006824-btcdjmfp 311 57 neurological neurological JJ cord-006824-btcdjmfp 311 58 abnormalities abnormality NNS cord-006824-btcdjmfp 311 59 and and CC cord-006824-btcdjmfp 311 60 extends extend VBZ cord-006824-btcdjmfp 311 61 their -PRON- PRP$ cord-006824-btcdjmfp 311 62 life life NN cord-006824-btcdjmfp 311 63 span span NN cord-006824-btcdjmfp 312 1 In in IN cord-006824-btcdjmfp 312 2 utero utero NN cord-006824-btcdjmfp 312 3 haematopoietic haematopoietic NNP cord-006824-btcdjmfp 312 4 stem stem NN cord-006824-btcdjmfp 312 5 cell cell NN cord-006824-btcdjmfp 312 6 transplantation transplantation NN cord-006824-btcdjmfp 312 7 : : : cord-006824-btcdjmfp 312 8 current current JJ cord-006824-btcdjmfp 312 9 perspectives perspective NNS cord-006824-btcdjmfp 312 10 and and CC cord-006824-btcdjmfp 312 11 future future JJ cord-006824-btcdjmfp 312 12 potential potential JJ cord-006824-btcdjmfp 312 13 Kinetics kinetic NNS cord-006824-btcdjmfp 312 14 of of IN cord-006824-btcdjmfp 312 15 central central JJ cord-006824-btcdjmfp 312 16 nervous nervous JJ cord-006824-btcdjmfp 312 17 system system NN cord-006824-btcdjmfp 312 18 microglial microglial NN cord-006824-btcdjmfp 312 19 and and CC cord-006824-btcdjmfp 312 20 macrophage macrophage NN cord-006824-btcdjmfp 312 21 engraftment engraftment NN cord-006824-btcdjmfp 312 22 : : : cord-006824-btcdjmfp 312 23 analysis analysis NN cord-006824-btcdjmfp 312 24 using use VBG cord-006824-btcdjmfp 312 25 a a DT cord-006824-btcdjmfp 312 26 transgenic transgenic JJ cord-006824-btcdjmfp 312 27 bone bone NN cord-006824-btcdjmfp 312 28 marrow marrow NN cord-006824-btcdjmfp 312 29 transplantation transplantation NN cord-006824-btcdjmfp 312 30 model model NN cord-006824-btcdjmfp 312 31 Transplant Transplant NNP cord-006824-btcdjmfp 312 32 - - HYPH cord-006824-btcdjmfp 312 33 lite lite NNP cord-006824-btcdjmfp 312 34 : : : cord-006824-btcdjmfp 312 35 induction induction NN cord-006824-btcdjmfp 312 36 of of IN cord-006824-btcdjmfp 312 37 graft graft NN cord-006824-btcdjmfp 312 38 - - HYPH cord-006824-btcdjmfp 312 39 versus versus IN cord-006824-btcdjmfp 312 40 - - HYPH cord-006824-btcdjmfp 312 41 malignancy malignancy NN cord-006824-btcdjmfp 312 42 using use VBG cord-006824-btcdjmfp 312 43 fludarabine fludarabine NN cord-006824-btcdjmfp 312 44 - - HYPH cord-006824-btcdjmfp 312 45 based base VBN cord-006824-btcdjmfp 312 46 nonablative nonablative JJ cord-006824-btcdjmfp 312 47 chemotherapy chemotherapy NN cord-006824-btcdjmfp 312 48 and and CC cord-006824-btcdjmfp 312 49 allogeneic allogeneic IN cord-006824-btcdjmfp 312 50 blood blood NN cord-006824-btcdjmfp 312 51 progenitor progenitor NN cord-006824-btcdjmfp 312 52 - - HYPH cord-006824-btcdjmfp 312 53 cell cell NN cord-006824-btcdjmfp 312 54 transplantation transplantation NN cord-006824-btcdjmfp 312 55 as as IN cord-006824-btcdjmfp 312 56 treatment treatment NN cord-006824-btcdjmfp 312 57 for for IN cord-006824-btcdjmfp 312 58 lymphoid lymphoid JJ cord-006824-btcdjmfp 312 59 malignancies malignancy NNS cord-006824-btcdjmfp 313 1 Late late JJ cord-006824-btcdjmfp 313 2 - - HYPH cord-006824-btcdjmfp 313 3 onset onset NN cord-006824-btcdjmfp 313 4 Krabbe Krabbe NNP cord-006824-btcdjmfp 313 5 disease disease NN cord-006824-btcdjmfp 313 6 ( ( -LRB- cord-006824-btcdjmfp 313 7 globoid globoid JJ cord-006824-btcdjmfp 313 8 cell cell NN cord-006824-btcdjmfp 313 9 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 313 10 ) ) -RRB- cord-006824-btcdjmfp 313 11 : : : cord-006824-btcdjmfp 314 1 clinical clinical JJ cord-006824-btcdjmfp 314 2 and and CC cord-006824-btcdjmfp 314 3 biochemical biochemical JJ cord-006824-btcdjmfp 314 4 features feature NNS cord-006824-btcdjmfp 314 5 of of IN cord-006824-btcdjmfp 314 6 15 15 CD cord-006824-btcdjmfp 314 7 cases case NNS cord-006824-btcdjmfp 314 8 Lysosomal Lysosomal NNP cord-006824-btcdjmfp 314 9 storage storage NN cord-006824-btcdjmfp 314 10 defects defect NNS cord-006824-btcdjmfp 314 11 Cells cell NNS cord-006824-btcdjmfp 314 12 expressing express VBG cord-006824-btcdjmfp 314 13 human human JJ cord-006824-btcdjmfp 314 14 glucocerebrosidase glucocerebrosidase NN cord-006824-btcdjmfp 314 15 from from IN cord-006824-btcdjmfp 314 16 a a DT cord-006824-btcdjmfp 314 17 retroviral retroviral JJ cord-006824-btcdjmfp 314 18 vector vector NN cord-006824-btcdjmfp 314 19 repopulate repopulate VBP cord-006824-btcdjmfp 314 20 macrophages macrophage NNS cord-006824-btcdjmfp 314 21 and and CC cord-006824-btcdjmfp 314 22 central central JJ cord-006824-btcdjmfp 314 23 nervous nervous JJ cord-006824-btcdjmfp 314 24 system system NN cord-006824-btcdjmfp 314 25 microglia microglia NNS cord-006824-btcdjmfp 314 26 after after IN cord-006824-btcdjmfp 314 27 murine murine JJ cord-006824-btcdjmfp 314 28 bone bone NN cord-006824-btcdjmfp 314 29 marrow marrow NN cord-006824-btcdjmfp 314 30 transplantation transplantation NN cord-006824-btcdjmfp 315 1 The the DT cord-006824-btcdjmfp 315 2 future future NN cord-006824-btcdjmfp 315 3 for for IN cord-006824-btcdjmfp 315 4 treatment treatment NN cord-006824-btcdjmfp 315 5 by by IN cord-006824-btcdjmfp 315 6 bone bone NN cord-006824-btcdjmfp 315 7 marrow marrow NN cord-006824-btcdjmfp 315 8 transplantation transplantation NN cord-006824-btcdjmfp 315 9 for for IN cord-006824-btcdjmfp 315 10 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 315 11 , , , cord-006824-btcdjmfp 315 12 metachromatic metachromatic NNP cord-006824-btcdjmfp 315 13 leukodystrophy leukodystrophy NNP cord-006824-btcdjmfp 315 14 , , , cord-006824-btcdjmfp 315 15 globoid globoid NNP cord-006824-btcdjmfp 315 16 cell cell NN cord-006824-btcdjmfp 315 17 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 315 18 , , , cord-006824-btcdjmfp 315 19 and and CC cord-006824-btcdjmfp 315 20 Hurler Hurler NNP cord-006824-btcdjmfp 315 21 syndrome syndrome NN cord-006824-btcdjmfp 315 22 Microglia Microglia NNP cord-006824-btcdjmfp 315 23 : : : cord-006824-btcdjmfp 315 24 the the DT cord-006824-btcdjmfp 315 25 effector effector JJ cord-006824-btcdjmfp 315 26 cell cell NN cord-006824-btcdjmfp 315 27 for for IN cord-006824-btcdjmfp 315 28 reconstitution reconstitution NN cord-006824-btcdjmfp 315 29 of of IN cord-006824-btcdjmfp 315 30 the the DT cord-006824-btcdjmfp 315 31 central central JJ cord-006824-btcdjmfp 315 32 nervous nervous JJ cord-006824-btcdjmfp 315 33 system system NN cord-006824-btcdjmfp 315 34 following follow VBG cord-006824-btcdjmfp 315 35 bone bone NN cord-006824-btcdjmfp 315 36 marrow marrow NN cord-006824-btcdjmfp 315 37 transplantation transplantation NN cord-006824-btcdjmfp 315 38 for for IN cord-006824-btcdjmfp 315 39 lysosomal lysosomal JJ cord-006824-btcdjmfp 315 40 and and CC cord-006824-btcdjmfp 315 41 peroxisomal peroxisomal JJ cord-006824-btcdjmfp 315 42 storage storage NN cord-006824-btcdjmfp 315 43 diseases disease NNS cord-006824-btcdjmfp 315 44 Bone Bone NNP cord-006824-btcdjmfp 315 45 marrow marrow NN cord-006824-btcdjmfp 315 46 transplantation transplantation NN cord-006824-btcdjmfp 315 47 treatment treatment NN cord-006824-btcdjmfp 315 48 for for IN cord-006824-btcdjmfp 315 49 globoid globoid NNP cord-006824-btcdjmfp 315 50 cell cell NN cord-006824-btcdjmfp 315 51 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 315 52 , , , cord-006824-btcdjmfp 315 53 metachromatic metachromatic JJ cord-006824-btcdjmfp 315 54 leukodystrophy leukodystrophy NNP cord-006824-btcdjmfp 315 55 , , , cord-006824-btcdjmfp 315 56 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 315 57 , , , cord-006824-btcdjmfp 315 58 and and CC cord-006824-btcdjmfp 315 59 Hurler Hurler NNP cord-006824-btcdjmfp 315 60 syndrome syndrome NN cord-006824-btcdjmfp 315 61 Hematopoietic Hematopoietic NNP cord-006824-btcdjmfp 315 62 stem stem NN cord-006824-btcdjmfp 315 63 - - HYPH cord-006824-btcdjmfp 315 64 cell cell NN cord-006824-btcdjmfp 315 65 transplantation transplantation NN cord-006824-btcdjmfp 315 66 in in IN cord-006824-btcdjmfp 315 67 globoid globoid JJ cord-006824-btcdjmfp 315 68 cell cell NN cord-006824-btcdjmfp 315 69 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 315 70 Bone Bone NNP cord-006824-btcdjmfp 315 71 marrow marrow NN cord-006824-btcdjmfp 315 72 transplantation transplantation NN cord-006824-btcdjmfp 315 73 as as IN cord-006824-btcdjmfp 315 74 effective effective JJ cord-006824-btcdjmfp 315 75 treatment treatment NN cord-006824-btcdjmfp 315 76 of of IN cord-006824-btcdjmfp 315 77 central central JJ cord-006824-btcdjmfp 315 78 nervous nervous JJ cord-006824-btcdjmfp 315 79 system system NN cord-006824-btcdjmfp 315 80 disease disease NN cord-006824-btcdjmfp 315 81 in in IN cord-006824-btcdjmfp 315 82 globoid globoid JJ cord-006824-btcdjmfp 315 83 cell cell NN cord-006824-btcdjmfp 315 84 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 315 85 , , , cord-006824-btcdjmfp 315 86 metachromatic metachromatic JJ cord-006824-btcdjmfp 315 87 leukodystrophy leukodystrophy NNP cord-006824-btcdjmfp 315 88 , , , cord-006824-btcdjmfp 315 89 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 315 90 , , , cord-006824-btcdjmfp 315 91 mannosidosis mannosidosis NNP cord-006824-btcdjmfp 315 92 , , , cord-006824-btcdjmfp 315 93 fucosidosis fucosidosis NNP cord-006824-btcdjmfp 315 94 , , , cord-006824-btcdjmfp 315 95 aspartylglucosaminuria aspartylglucosaminuria NNP cord-006824-btcdjmfp 315 96 , , , cord-006824-btcdjmfp 315 97 Hurler Hurler NNP cord-006824-btcdjmfp 315 98 , , , cord-006824-btcdjmfp 315 99 Maroteaux Maroteaux NNP cord-006824-btcdjmfp 315 100 - - HYPH cord-006824-btcdjmfp 315 101 Lamy Lamy NNP cord-006824-btcdjmfp 315 102 and and CC cord-006824-btcdjmfp 315 103 Sly Sly NNP cord-006824-btcdjmfp 315 104 syndromes syndrome NNS cord-006824-btcdjmfp 315 105 , , , cord-006824-btcdjmfp 315 106 and and CC cord-006824-btcdjmfp 315 107 Gaucher Gaucher NNP cord-006824-btcdjmfp 315 108 disease disease NN cord-006824-btcdjmfp 315 109 type type NN cord-006824-btcdjmfp 315 110 III III NNP cord-006824-btcdjmfp 316 1 The the DT cord-006824-btcdjmfp 316 2 Metabolic Metabolic NNP cord-006824-btcdjmfp 316 3 and and CC cord-006824-btcdjmfp 316 4 Molecular Molecular NNP cord-006824-btcdjmfp 316 5 Bases Bases NNPS cord-006824-btcdjmfp 316 6 of of IN cord-006824-btcdjmfp 316 7 Inherited Inherited NNP cord-006824-btcdjmfp 316 8 Disease Disease NNP cord-006824-btcdjmfp 316 9 Farber Farber NNP cord-006824-btcdjmfp 316 10 disease disease NN cord-006824-btcdjmfp 316 11 ( ( -LRB- cord-006824-btcdjmfp 316 12 lipogranulomatosis lipogranulomatosis NN cord-006824-btcdjmfp 316 13 ) ) -RRB- cord-006824-btcdjmfp 317 1 The the DT cord-006824-btcdjmfp 317 2 gene gene NN cord-006824-btcdjmfp 317 3 responsible responsible JJ cord-006824-btcdjmfp 317 4 for for IN cord-006824-btcdjmfp 317 5 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 317 6 encodes encode VBZ cord-006824-btcdjmfp 317 7 a a DT cord-006824-btcdjmfp 317 8 peroxisomal peroxisomal JJ cord-006824-btcdjmfp 317 9 membrane membrane NN cord-006824-btcdjmfp 317 10 protein protein NN cord-006824-btcdjmfp 317 11 Differentiation differentiation NN cord-006824-btcdjmfp 317 12 of of IN cord-006824-btcdjmfp 317 13 transplanted transplant VBN cord-006824-btcdjmfp 317 14 bone bone NN cord-006824-btcdjmfp 317 15 marrow marrow NN cord-006824-btcdjmfp 317 16 cells cell NNS cord-006824-btcdjmfp 317 17 in in IN cord-006824-btcdjmfp 317 18 the the DT cord-006824-btcdjmfp 317 19 adult adult NN cord-006824-btcdjmfp 317 20 mouse mouse NN cord-006824-btcdjmfp 317 21 brain brain NN cord-006824-btcdjmfp 318 1 Lysosomal lysosomal JJ cord-006824-btcdjmfp 318 2 storage storage NN cord-006824-btcdjmfp 318 3 diseases disease NNS cord-006824-btcdjmfp 318 4 Cells cell NNS cord-006824-btcdjmfp 318 5 capable capable JJ cord-006824-btcdjmfp 318 6 of of IN cord-006824-btcdjmfp 318 7 bone bone NN cord-006824-btcdjmfp 318 8 production production NN cord-006824-btcdjmfp 318 9 engraft engraft NN cord-006824-btcdjmfp 318 10 from from IN cord-006824-btcdjmfp 318 11 whole whole JJ cord-006824-btcdjmfp 318 12 bone bone NN cord-006824-btcdjmfp 318 13 marrow marrow NN cord-006824-btcdjmfp 318 14 transplants transplant NNS cord-006824-btcdjmfp 318 15 in in IN cord-006824-btcdjmfp 318 16 nonablated nonablated JJ cord-006824-btcdjmfp 318 17 mice mice NN cord-006824-btcdjmfp 318 18 Role role NN cord-006824-btcdjmfp 318 19 of of IN cord-006824-btcdjmfp 318 20 cell cell NN cord-006824-btcdjmfp 318 21 adhesion adhesion NN cord-006824-btcdjmfp 318 22 in in IN cord-006824-btcdjmfp 318 23 contact contact NN cord-006824-btcdjmfp 318 24 - - HYPH cord-006824-btcdjmfp 318 25 dependent dependent JJ cord-006824-btcdjmfp 318 26 transfer transfer NN cord-006824-btcdjmfp 318 27 of of IN cord-006824-btcdjmfp 318 28 a a DT cord-006824-btcdjmfp 318 29 lysosomal lysosomal JJ cord-006824-btcdjmfp 318 30 enzyme enzyme NN cord-006824-btcdjmfp 318 31 from from IN cord-006824-btcdjmfp 318 32 lymphocytes lymphocyte NNS cord-006824-btcdjmfp 318 33 to to IN cord-006824-btcdjmfp 318 34 fibroblasts fibroblast NNS cord-006824-btcdjmfp 318 35 Macrophages macrophage NNS cord-006824-btcdjmfp 318 36 and and CC cord-006824-btcdjmfp 318 37 the the DT cord-006824-btcdjmfp 318 38 nervous nervous JJ cord-006824-btcdjmfp 318 39 system system NN cord-006824-btcdjmfp 318 40 Outcome outcome NN cord-006824-btcdjmfp 318 41 of of IN cord-006824-btcdjmfp 318 42 unrelated unrelated JJ cord-006824-btcdjmfp 318 43 donor donor NN cord-006824-btcdjmfp 318 44 bone bone NN cord-006824-btcdjmfp 318 45 marrow marrow NN cord-006824-btcdjmfp 318 46 transplantation transplantation NN cord-006824-btcdjmfp 318 47 in in IN cord-006824-btcdjmfp 318 48 40 40 CD cord-006824-btcdjmfp 318 49 children child NNS cord-006824-btcdjmfp 318 50 with with IN cord-006824-btcdjmfp 318 51 Hurler Hurler NNP cord-006824-btcdjmfp 318 52 syndrome syndrome NN cord-006824-btcdjmfp 318 53 Hurler Hurler NNP cord-006824-btcdjmfp 318 54 syndrome syndrome NN cord-006824-btcdjmfp 318 55 : : : cord-006824-btcdjmfp 318 56 II II NNP cord-006824-btcdjmfp 318 57 . . . cord-006824-btcdjmfp 319 1 Outcome outcome NN cord-006824-btcdjmfp 319 2 of of IN cord-006824-btcdjmfp 319 3 HLAgenotypically hlagenotypically RB cord-006824-btcdjmfp 320 1 identical identical JJ cord-006824-btcdjmfp 320 2 sibling sibling NN cord-006824-btcdjmfp 320 3 and and CC cord-006824-btcdjmfp 320 4 HLA HLA NNP cord-006824-btcdjmfp 320 5 - - HYPH cord-006824-btcdjmfp 320 6 haploidentical haploidentical JJ cord-006824-btcdjmfp 320 7 related related JJ cord-006824-btcdjmfp 320 8 donor donor NN cord-006824-btcdjmfp 320 9 bone bone NN cord-006824-btcdjmfp 320 10 marrow marrow NN cord-006824-btcdjmfp 320 11 transplantation transplantation NN cord-006824-btcdjmfp 320 12 in in IN cord-006824-btcdjmfp 320 13 fifty fifty CD cord-006824-btcdjmfp 320 14 - - HYPH cord-006824-btcdjmfp 320 15 four four CD cord-006824-btcdjmfp 320 16 children child NNS cord-006824-btcdjmfp 320 17 . . . cord-006824-btcdjmfp 321 1 The the DT cord-006824-btcdjmfp 321 2 Storage Storage NNP cord-006824-btcdjmfp 321 3 Disease Disease NNP cord-006824-btcdjmfp 321 4 Collaborative Collaborative NNP cord-006824-btcdjmfp 321 5 Study Study NNP cord-006824-btcdjmfp 321 6 Group Group NNP cord-006824-btcdjmfp 321 7 Targeting Targeting NNP cord-006824-btcdjmfp 321 8 of of IN cord-006824-btcdjmfp 321 9 proteins protein NNS cord-006824-btcdjmfp 321 10 to to IN cord-006824-btcdjmfp 321 11 the the DT cord-006824-btcdjmfp 321 12 lysosome lysosome NN cord-006824-btcdjmfp 321 13 Marrow Marrow NNP cord-006824-btcdjmfp 321 14 stromal stromal NN cord-006824-btcdjmfp 321 15 cells cell NNS cord-006824-btcdjmfp 321 16 as as IN cord-006824-btcdjmfp 321 17 stem stem NN cord-006824-btcdjmfp 321 18 cells cell NNS cord-006824-btcdjmfp 321 19 for for IN cord-006824-btcdjmfp 321 20 nonhematopoietic nonhematopoietic JJ cord-006824-btcdjmfp 321 21 tissues tissue NNS cord-006824-btcdjmfp 321 22 Endocytosis Endocytosis NNP cord-006824-btcdjmfp 321 23 and and CC cord-006824-btcdjmfp 321 24 trancytosis trancytosis NNP cord-006824-btcdjmfp 321 25 Gene Gene NNP cord-006824-btcdjmfp 321 26 therapy therapy NN cord-006824-btcdjmfp 321 27 of of IN cord-006824-btcdjmfp 321 28 lysosomal lysosomal JJ cord-006824-btcdjmfp 321 29 storage storage NN cord-006824-btcdjmfp 321 30 disorders disorder NNS cord-006824-btcdjmfp 322 1 Murine murine JJ cord-006824-btcdjmfp 322 2 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 322 3 type type NN cord-006824-btcdjmfp 322 4 VII vii NN cord-006824-btcdjmfp 322 5 : : : cord-006824-btcdjmfp 322 6 long long JJ cord-006824-btcdjmfp 322 7 term term NN cord-006824-btcdjmfp 322 8 therapeutic therapeutic JJ cord-006824-btcdjmfp 322 9 effects effect NNS cord-006824-btcdjmfp 322 10 of of IN cord-006824-btcdjmfp 322 11 enzyme enzyme NN cord-006824-btcdjmfp 322 12 replacement replacement NN cord-006824-btcdjmfp 322 13 and and CC cord-006824-btcdjmfp 322 14 enzyme enzyme NN cord-006824-btcdjmfp 322 15 replacement replacement NN cord-006824-btcdjmfp 322 16 followed follow VBN cord-006824-btcdjmfp 322 17 by by IN cord-006824-btcdjmfp 322 18 bone bone NN cord-006824-btcdjmfp 322 19 marrow marrow NN cord-006824-btcdjmfp 322 20 transplantation transplantation NN cord-006824-btcdjmfp 322 21 Neuropsychological neuropsychological JJ cord-006824-btcdjmfp 322 22 outcomes outcome NNS cord-006824-btcdjmfp 322 23 of of IN cord-006824-btcdjmfp 322 24 several several JJ cord-006824-btcdjmfp 322 25 storage storage NN cord-006824-btcdjmfp 322 26 diseases disease NNS cord-006824-btcdjmfp 322 27 with with IN cord-006824-btcdjmfp 322 28 and and CC cord-006824-btcdjmfp 322 29 without without IN cord-006824-btcdjmfp 322 30 bone bone NN cord-006824-btcdjmfp 322 31 marrow marrow NN cord-006824-btcdjmfp 322 32 transplantation transplantation NN cord-006824-btcdjmfp 322 33 Long long JJ cord-006824-btcdjmfp 322 34 - - HYPH cord-006824-btcdjmfp 322 35 term term NN cord-006824-btcdjmfp 322 36 effect effect NN cord-006824-btcdjmfp 322 37 of of IN cord-006824-btcdjmfp 322 38 bone bone NN cord-006824-btcdjmfp 322 39 - - HYPH cord-006824-btcdjmfp 322 40 marrow marrow NN cord-006824-btcdjmfp 322 41 transplantation transplantation NN cord-006824-btcdjmfp 322 42 for for IN cord-006824-btcdjmfp 322 43 childhood childhood NN cord-006824-btcdjmfp 322 44 - - HYPH cord-006824-btcdjmfp 322 45 onset onset NN cord-006824-btcdjmfp 322 46 cerebral cerebral JJ cord-006824-btcdjmfp 322 47 X x NN cord-006824-btcdjmfp 322 48 - - HYPH cord-006824-btcdjmfp 322 49 linked link VBN cord-006824-btcdjmfp 322 50 adrenoleukodystrophy adrenoleukodystrophy NN cord-006824-btcdjmfp 322 51 Bone bone NN cord-006824-btcdjmfp 322 52 marrow marrow NN cord-006824-btcdjmfp 322 53 transplantation transplantation NN cord-006824-btcdjmfp 322 54 in in IN cord-006824-btcdjmfp 322 55 canine canine JJ cord-006824-btcdjmfp 322 56 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 322 57 I. I. NNP cord-006824-btcdjmfp 322 58 Effects Effects NNP cord-006824-btcdjmfp 322 59 within within IN cord-006824-btcdjmfp 322 60 the the DT cord-006824-btcdjmfp 322 61 central central JJ cord-006824-btcdjmfp 322 62 nervous nervous JJ cord-006824-btcdjmfp 322 63 system system NN cord-006824-btcdjmfp 322 64 Nonmyeloablative Nonmyeloablative NNP cord-006824-btcdjmfp 322 65 stem stem NN cord-006824-btcdjmfp 322 66 cell cell NN cord-006824-btcdjmfp 322 67 transplantation transplantation NN cord-006824-btcdjmfp 322 68 and and CC cord-006824-btcdjmfp 322 69 cell cell NN cord-006824-btcdjmfp 322 70 therapy therapy NN cord-006824-btcdjmfp 322 71 as as IN cord-006824-btcdjmfp 322 72 an an DT cord-006824-btcdjmfp 322 73 alternative alternative NN cord-006824-btcdjmfp 322 74 to to IN cord-006824-btcdjmfp 322 75 conventional conventional JJ cord-006824-btcdjmfp 322 76 bone bone NN cord-006824-btcdjmfp 322 77 marrow marrow NN cord-006824-btcdjmfp 322 78 transplantation transplantation NN cord-006824-btcdjmfp 322 79 with with IN cord-006824-btcdjmfp 322 80 lethal lethal JJ cord-006824-btcdjmfp 322 81 cytoreduction cytoreduction NN cord-006824-btcdjmfp 322 82 for for IN cord-006824-btcdjmfp 322 83 the the DT cord-006824-btcdjmfp 322 84 treatment treatment NN cord-006824-btcdjmfp 322 85 of of IN cord-006824-btcdjmfp 322 86 malignant malignant JJ cord-006824-btcdjmfp 322 87 and and CC cord-006824-btcdjmfp 322 88 nonmalignant nonmalignant JJ cord-006824-btcdjmfp 322 89 hematologic hematologic JJ cord-006824-btcdjmfp 322 90 diseases disease NNS cord-006824-btcdjmfp 323 1 Outcome outcome NN cord-006824-btcdjmfp 323 2 of of IN cord-006824-btcdjmfp 323 3 displacement displacement NN cord-006824-btcdjmfp 323 4 bone bone NN cord-006824-btcdjmfp 323 5 marrow marrow NN cord-006824-btcdjmfp 323 6 transplantation transplantation NN cord-006824-btcdjmfp 323 7 in in IN cord-006824-btcdjmfp 323 8 Farber Farber NNP cord-006824-btcdjmfp 323 9 's 's POS cord-006824-btcdjmfp 323 10 disease disease NN cord-006824-btcdjmfp 323 11 : : : cord-006824-btcdjmfp 323 12 a a DT cord-006824-btcdjmfp 323 13 report report NN cord-006824-btcdjmfp 323 14 of of IN cord-006824-btcdjmfp 323 15 a a DT cord-006824-btcdjmfp 323 16 case case NN cord-006824-btcdjmfp 323 17 Genetic genetic JJ cord-006824-btcdjmfp 323 18 disorders disorder NNS cord-006824-btcdjmfp 323 19 of of IN cord-006824-btcdjmfp 323 20 lipid lipid NN cord-006824-btcdjmfp 323 21 , , , cord-006824-btcdjmfp 323 22 glucoprotein glucoprotein NNP cord-006824-btcdjmfp 323 23 , , , cord-006824-btcdjmfp 323 24 and and CC cord-006824-btcdjmfp 323 25 mucopolysaccharide mucopolysaccharide NN cord-006824-btcdjmfp 323 26 metabolism metabolism NN cord-006824-btcdjmfp 324 1 The the DT cord-006824-btcdjmfp 324 2 twitcher twitcher NN cord-006824-btcdjmfp 324 3 mouse mouse NN cord-006824-btcdjmfp 324 4 : : : cord-006824-btcdjmfp 324 5 a a DT cord-006824-btcdjmfp 324 6 model model NN cord-006824-btcdjmfp 324 7 for for IN cord-006824-btcdjmfp 324 8 Krabbe Krabbe NNP cord-006824-btcdjmfp 324 9 disease disease NN cord-006824-btcdjmfp 324 10 and and CC cord-006824-btcdjmfp 324 11 for for IN cord-006824-btcdjmfp 324 12 experimental experimental JJ cord-006824-btcdjmfp 324 13 therapies therapy NNS cord-006824-btcdjmfp 324 14 Nerve nerve NN cord-006824-btcdjmfp 324 15 conduction conduction NN cord-006824-btcdjmfp 324 16 studies study NNS cord-006824-btcdjmfp 324 17 in in IN cord-006824-btcdjmfp 324 18 the the DT cord-006824-btcdjmfp 324 19 twitcher twitcher NN cord-006824-btcdjmfp 324 20 mouse mouse NN cord-006824-btcdjmfp 324 21 ( ( -LRB- cord-006824-btcdjmfp 324 22 murine murine JJ cord-006824-btcdjmfp 324 23 globoid globoid JJ cord-006824-btcdjmfp 324 24 cell cell NN cord-006824-btcdjmfp 324 25 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 324 26 ) ) -RRB- cord-006824-btcdjmfp 325 1 Male male JJ cord-006824-btcdjmfp 325 2 donor donor NN cord-006824-btcdjmfp 325 3 - - HYPH cord-006824-btcdjmfp 325 4 derived derive VBN cord-006824-btcdjmfp 325 5 cells cell NNS cord-006824-btcdjmfp 325 6 in in IN cord-006824-btcdjmfp 325 7 the the DT cord-006824-btcdjmfp 325 8 brains brain NNS cord-006824-btcdjmfp 325 9 of of IN cord-006824-btcdjmfp 325 10 female female JJ cord-006824-btcdjmfp 325 11 sex sex NN cord-006824-btcdjmfp 325 12 - - HYPH cord-006824-btcdjmfp 325 13 mismatched mismatch VBN cord-006824-btcdjmfp 325 14 bone bone NN cord-006824-btcdjmfp 325 15 marrow marrow NN cord-006824-btcdjmfp 325 16 transplant transplant NN cord-006824-btcdjmfp 325 17 recipients recipient NNS cord-006824-btcdjmfp 325 18 : : : cord-006824-btcdjmfp 325 19 a a DT cord-006824-btcdjmfp 325 20 Ychromosome Ychromosome NNP cord-006824-btcdjmfp 325 21 specific specific JJ cord-006824-btcdjmfp 325 22 in in IN cord-006824-btcdjmfp 325 23 situ situ JJ cord-006824-btcdjmfp 325 24 hybridization hybridization NN cord-006824-btcdjmfp 325 25 study study NN cord-006824-btcdjmfp 325 26 Bone Bone NNP cord-006824-btcdjmfp 325 27 marrow marrow NN cord-006824-btcdjmfp 325 28 transplantation transplantation NN cord-006824-btcdjmfp 325 29 corrects correct VBZ cord-006824-btcdjmfp 325 30 the the DT cord-006824-btcdjmfp 325 31 enzyme enzyme NN cord-006824-btcdjmfp 325 32 defect defect NN cord-006824-btcdjmfp 325 33 in in IN cord-006824-btcdjmfp 325 34 neurons neuron NNS cord-006824-btcdjmfp 325 35 of of IN cord-006824-btcdjmfp 325 36 the the DT cord-006824-btcdjmfp 325 37 central central JJ cord-006824-btcdjmfp 325 38 nervous nervous JJ cord-006824-btcdjmfp 325 39 system system NN cord-006824-btcdjmfp 325 40 in in IN cord-006824-btcdjmfp 325 41 a a DT cord-006824-btcdjmfp 325 42 lysosomal lysosomal JJ cord-006824-btcdjmfp 325 43 storage storage NN cord-006824-btcdjmfp 325 44 disease disease NN cord-006824-btcdjmfp 326 1 The the DT cord-006824-btcdjmfp 326 2 mucopolysaccharidoses mucopolysaccharidose NNS cord-006824-btcdjmfp 326 3 Longterm Longterm NNP cord-006824-btcdjmfp 326 4 outcome outcome NN cord-006824-btcdjmfp 326 5 of of IN cord-006824-btcdjmfp 326 6 Hurler Hurler NNP cord-006824-btcdjmfp 326 7 syndrome syndrome NN cord-006824-btcdjmfp 326 8 following follow VBG cord-006824-btcdjmfp 326 9 bone bone NN cord-006824-btcdjmfp 326 10 marrow marrow NN cord-006824-btcdjmfp 326 11 transplantation transplantation NN cord-006824-btcdjmfp 326 12 Reversal reversal NN cord-006824-btcdjmfp 326 13 of of IN cord-006824-btcdjmfp 326 14 pathology pathology NN cord-006824-btcdjmfp 326 15 in in IN cord-006824-btcdjmfp 326 16 murine murine JJ cord-006824-btcdjmfp 326 17 mucopolysaccharidosis mucopolysaccharidosis NN cord-006824-btcdjmfp 326 18 type type NN cord-006824-btcdjmfp 326 19 VII VII NNP cord-006824-btcdjmfp 326 20 by by IN cord-006824-btcdjmfp 327 1 somatic somatic JJ cord-006824-btcdjmfp 327 2 cell cell NN cord-006824-btcdjmfp 327 3 gene gene NN cord-006824-btcdjmfp 327 4 transfer transfer NN cord-006824-btcdjmfp 327 5 Stem Stem NNP cord-006824-btcdjmfp 327 6 cell cell NN cord-006824-btcdjmfp 327 7 transplantation transplantation NN cord-006824-btcdjmfp 327 8 in in IN cord-006824-btcdjmfp 327 9 lysosomal lysosomal JJ cord-006824-btcdjmfp 327 10 storage storage NN cord-006824-btcdjmfp 327 11 diseases disease NNS cord-006824-btcdjmfp 328 1 Prolonged prolonged JJ cord-006824-btcdjmfp 328 2 survival survival NN cord-006824-btcdjmfp 328 3 and and CC cord-006824-btcdjmfp 328 4 remyelination remyelination NN cord-006824-btcdjmfp 328 5 after after IN cord-006824-btcdjmfp 328 6 hematopoietic hematopoietic JJ cord-006824-btcdjmfp 328 7 cell cell NN cord-006824-btcdjmfp 328 8 transplantation transplantation NN cord-006824-btcdjmfp 328 9 in in IN cord-006824-btcdjmfp 328 10 the the DT cord-006824-btcdjmfp 328 11 twitcher twitcher NN cord-006824-btcdjmfp 328 12 mouse mouse NN cord-006824-btcdjmfp 328 13 ( ( -LRB- cord-006824-btcdjmfp 328 14 murine murine JJ cord-006824-btcdjmfp 328 15 globoid globoid JJ cord-006824-btcdjmfp 328 16 cell cell NN cord-006824-btcdjmfp 328 17 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 328 18 ) ) -RRB- cord-006824-btcdjmfp 329 1 Hematopoietic hematopoietic JJ cord-006824-btcdjmfp 329 2 cell cell NN cord-006824-btcdjmfp 329 3 transplantation transplantation NN cord-006824-btcdjmfp 329 4 after after IN cord-006824-btcdjmfp 329 5 administration administration NN cord-006824-btcdjmfp 329 6 of of IN cord-006824-btcdjmfp 329 7 high high JJ cord-006824-btcdjmfp 329 8 - - HYPH cord-006824-btcdjmfp 329 9 dose dose NN cord-006824-btcdjmfp 329 10 busulfan busulfan NN cord-006824-btcdjmfp 329 11 in in IN cord-006824-btcdjmfp 329 12 murine murine JJ cord-006824-btcdjmfp 329 13 globoid globoid JJ cord-006824-btcdjmfp 329 14 cell cell NN cord-006824-btcdjmfp 329 15 leukodystrophy leukodystrophy NN cord-006824-btcdjmfp 329 16 ( ( -LRB- cord-006824-btcdjmfp 329 17 the the DT cord-006824-btcdjmfp 329 18 twitcher twitcher NN cord-006824-btcdjmfp 329 19 mouse mouse NN cord-006824-btcdjmfp 330 1 ) ) -RRB- cord-006824-btcdjmfp 330 2 Repopulation repopulation NN cord-006824-btcdjmfp 330 3 by by IN cord-006824-btcdjmfp 330 4 donor donor NN cord-006824-btcdjmfp 330 5 - - HYPH cord-006824-btcdjmfp 330 6 derived derive VBN cord-006824-btcdjmfp 330 7 macrophages macrophage NNS cord-006824-btcdjmfp 330 8 in in IN cord-006824-btcdjmfp 330 9 the the DT cord-006824-btcdjmfp 330 10 murine murine JJ cord-006824-btcdjmfp 330 11 central central JJ cord-006824-btcdjmfp 330 12 nervous nervous JJ cord-006824-btcdjmfp 330 13 system system NN cord-006824-btcdjmfp 330 14 ( ( -LRB- cord-006824-btcdjmfp 330 15 CNS CNS NNP cord-006824-btcdjmfp 330 16 ) ) -RRB- cord-006824-btcdjmfp 330 17 after after IN cord-006824-btcdjmfp 330 18 congenic congenic NNP cord-006824-btcdjmfp 330 19 bone bone NN cord-006824-btcdjmfp 330 20 marrow marrow NN cord-006824-btcdjmfp 330 21 transplantation transplantation NN cord-006824-btcdjmfp 330 22 ( ( -LRB- cord-006824-btcdjmfp 330 23 BMT BMT NNP cord-006824-btcdjmfp 330 24 ) ) -RRB- cord-006824-btcdjmfp 330 25 : : : cord-006824-btcdjmfp 330 26 a a DT cord-006824-btcdjmfp 330 27 quantitative quantitative JJ cord-006824-btcdjmfp 330 28 study study NN cord-006824-btcdjmfp 330 29 Hematopoietic hematopoietic JJ cord-006824-btcdjmfp 330 30 cell cell NN cord-006824-btcdjmfp 330 31 transplantation transplantation NN cord-006824-btcdjmfp 330 32 in in IN cord-006824-btcdjmfp 330 33 the the DT cord-006824-btcdjmfp 330 34 twitcher twitcher NN cord-006824-btcdjmfp 330 35 mouse mouse NN cord-006824-btcdjmfp 330 36 . . . cord-006824-btcdjmfp 331 1 The the DT cord-006824-btcdjmfp 331 2 effects effect NNS cord-006824-btcdjmfp 331 3 of of IN cord-006824-btcdjmfp 331 4 pretransplant pretransplant NN cord-006824-btcdjmfp 331 5 conditioning conditioning NN cord-006824-btcdjmfp 331 6 with with IN cord-006824-btcdjmfp 331 7 graded grade VBN cord-006824-btcdjmfp 331 8 doses dose NNS cord-006824-btcdjmfp 331 9 of of IN cord-006824-btcdjmfp 331 10 busulfan busulfan NNP cord-006824-btcdjmfp 331 11 Bone Bone NNP cord-006824-btcdjmfp 331 12 marrow marrow NN cord-006824-btcdjmfp 331 13 transplantation transplantation NN cord-006824-btcdjmfp 331 14 for for IN cord-006824-btcdjmfp 331 15 infantile infantile JJ cord-006824-btcdjmfp 331 16 ceramidase ceramidase NN cord-006824-btcdjmfp 331 17 deficiency deficiency NN cord-006824-btcdjmfp 331 18 ( ( -LRB- cord-006824-btcdjmfp 331 19 Farber Farber NNP cord-006824-btcdjmfp 331 20 disease disease NN cord-006824-btcdjmfp 331 21 ) ) -RRB-