id	sid	tid	token	lemma	pos
cord-017917-7aeh6quc	1	1	key	key	JJ
cord-017917-7aeh6quc	1	2	:	:	:
cord-017917-7aeh6quc	1	3	cord-017917	cord-017917	NNP
cord-017917-7aeh6quc	1	4	-	-	HYPH
cord-017917-7aeh6quc	1	5	7aeh6quc	7aeh6quc	CD
cord-017917-7aeh6quc	1	6	authors	author	NNS
cord-017917-7aeh6quc	1	7	:	:	:
cord-017917-7aeh6quc	1	8	Marten	Marten	NNP
cord-017917-7aeh6quc	1	9	,	,	,
cord-017917-7aeh6quc	1	10	Norman	Norman	NNP
cord-017917-7aeh6quc	1	11	W.	W.	NNP
cord-017917-7aeh6quc	1	12	;	;	:
cord-017917-7aeh6quc	1	13	Zhou	Zhou	NNP
cord-017917-7aeh6quc	1	14	,	,	,
cord-017917-7aeh6quc	1	15	Jiehao	Jiehao	NNP
cord-017917-7aeh6quc	1	16	title	title	NN
cord-017917-7aeh6quc	1	17	:	:	:
cord-017917-7aeh6quc	1	18	The	the	DT
cord-017917-7aeh6quc	1	19	Role	role	NN
cord-017917-7aeh6quc	1	20	of	of	IN
cord-017917-7aeh6quc	1	21	Metalloproteinases	Metalloproteinases	NNP
cord-017917-7aeh6quc	1	22	in	in	IN
cord-017917-7aeh6quc	1	23	Corona	Corona	NNP
cord-017917-7aeh6quc	1	24	Virus	Virus	NNP
cord-017917-7aeh6quc	1	25	Infection	Infection	NNP
cord-017917-7aeh6quc	1	26	date	date	NN
cord-017917-7aeh6quc	1	27	:	:	:
cord-017917-7aeh6quc	1	28	2005	2005	CD
cord-017917-7aeh6quc	1	29	journal	journal	NN
cord-017917-7aeh6quc	1	30	:	:	:
cord-017917-7aeh6quc	1	31	Experimental	Experimental	NNP
cord-017917-7aeh6quc	1	32	Models	Models	NNPS
cord-017917-7aeh6quc	1	33	of	of	IN
cord-017917-7aeh6quc	1	34	Multiple	Multiple	NNP
cord-017917-7aeh6quc	1	35	Sclerosis	Sclerosis	NNP
cord-017917-7aeh6quc	1	36	DOI	doi	NN
cord-017917-7aeh6quc	1	37	:	:	:
cord-017917-7aeh6quc	2	1	10.1007/0	10.1007/0	CD
cord-017917-7aeh6quc	2	2	-	-	SYM
cord-017917-7aeh6quc	2	3	387	387	CD
cord-017917-7aeh6quc	2	4	-	-	HYPH
cord-017917-7aeh6quc	2	5	25518	25518	CD
cord-017917-7aeh6quc	2	6	-	-	HYPH
cord-017917-7aeh6quc	2	7	4_48	4_48	CD
cord-017917-7aeh6quc	3	1	sha	sha	NNP
cord-017917-7aeh6quc	3	2	:	:	:
cord-017917-7aeh6quc	3	3	47dec3f246098058239e284844e835dd1122b999	47dec3f246098058239e284844e835dd1122b999	CD
cord-017917-7aeh6quc	3	4	doc_id	doc_id	CD
cord-017917-7aeh6quc	3	5	:	:	:
cord-017917-7aeh6quc	4	1	17917	17917	CD
cord-017917-7aeh6quc	4	2	cord_uid	cord_uid	NNS
cord-017917-7aeh6quc	4	3	:	:	:
cord-017917-7aeh6quc	4	4	7aeh6quc	7aeh6quc	CD
cord-017917-7aeh6quc	4	5	Infection	infection	NN
cord-017917-7aeh6quc	4	6	with	with	IN
cord-017917-7aeh6quc	4	7	neurotropic	neurotropic	NNP
cord-017917-7aeh6quc	4	8	strains	strain	NNS
cord-017917-7aeh6quc	4	9	of	of	IN
cord-017917-7aeh6quc	5	1	mouse	mouse	NNP
cord-017917-7aeh6quc	5	2	hepatitis	hepatitis	NNP
cord-017917-7aeh6quc	5	3	virus	virus	NN
cord-017917-7aeh6quc	5	4	(	(	-LRB-
cord-017917-7aeh6quc	5	5	MHV	MHV	NNP
cord-017917-7aeh6quc	5	6	)	)	-RRB-
cord-017917-7aeh6quc	5	7	results	result	VBZ
cord-017917-7aeh6quc	5	8	in	in	IN
cord-017917-7aeh6quc	5	9	rapid	rapid	JJ
cord-017917-7aeh6quc	5	10	leukocyte	leukocyte	NN
cord-017917-7aeh6quc	5	11	infiltration	infiltration	NN
cord-017917-7aeh6quc	5	12	into	into	IN
cord-017917-7aeh6quc	5	13	the	the	DT
cord-017917-7aeh6quc	5	14	central	central	JJ
cord-017917-7aeh6quc	5	15	nervous	nervous	JJ
cord-017917-7aeh6quc	5	16	system	system	NN
cord-017917-7aeh6quc	5	17	(	(	-LRB-
cord-017917-7aeh6quc	5	18	CNS	CNS	NNP
cord-017917-7aeh6quc	5	19	)	)	-RRB-
cord-017917-7aeh6quc	5	20	.	.	.
cord-017917-7aeh6quc	6	1	The	the	DT
cord-017917-7aeh6quc	6	2	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	6	3	response	response	NN
cord-017917-7aeh6quc	6	4	controls	control	VBZ
cord-017917-7aeh6quc	6	5	virus	virus	NN
cord-017917-7aeh6quc	6	6	replication	replication	NN
cord-017917-7aeh6quc	6	7	but	but	CC
cord-017917-7aeh6quc	6	8	fails	fail	VBZ
cord-017917-7aeh6quc	6	9	to	to	TO
cord-017917-7aeh6quc	6	10	mediate	mediate	VB
cord-017917-7aeh6quc	6	11	sterile	sterile	JJ
cord-017917-7aeh6quc	6	12	clearance	clearance	NN
cord-017917-7aeh6quc	6	13	.	.	.
cord-017917-7aeh6quc	7	1	The	the	DT
cord-017917-7aeh6quc	7	2	persistence	persistence	NN
cord-017917-7aeh6quc	7	3	of	of	IN
cord-017917-7aeh6quc	7	4	viral	viral	JJ
cord-017917-7aeh6quc	7	5	RNA	RNA	NNP
cord-017917-7aeh6quc	7	6	and	and	CC
cord-017917-7aeh6quc	7	7	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	7	8	cells	cell	NNS
cord-017917-7aeh6quc	7	9	within	within	IN
cord-017917-7aeh6quc	7	10	the	the	DT
cord-017917-7aeh6quc	7	11	CNS	CNS	NNP
cord-017917-7aeh6quc	7	12	is	be	VBZ
cord-017917-7aeh6quc	7	13	associated	associate	VBN
cord-017917-7aeh6quc	7	14	with	with	IN
cord-017917-7aeh6quc	7	15	the	the	DT
cord-017917-7aeh6quc	7	16	development	development	NN
cord-017917-7aeh6quc	7	17	of	of	IN
cord-017917-7aeh6quc	7	18	ongoing	ongoing	JJ
cord-017917-7aeh6quc	7	19	demyelination	demyelination	NN
cord-017917-7aeh6quc	7	20	.	.	.
cord-017917-7aeh6quc	8	1	Matrix	matrix	NN
cord-017917-7aeh6quc	8	2	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	8	3	(	(	-LRB-
cord-017917-7aeh6quc	8	4	MMPs	MMPs	NNP
cord-017917-7aeh6quc	8	5	)	)	-RRB-
cord-017917-7aeh6quc	8	6	are	be	VBP
cord-017917-7aeh6quc	8	7	a	a	DT
cord-017917-7aeh6quc	8	8	family	family	NN
cord-017917-7aeh6quc	8	9	of	of	IN
cord-017917-7aeh6quc	8	10	proteases	protease	NNS
cord-017917-7aeh6quc	8	11	involved	involve	VBN
cord-017917-7aeh6quc	8	12	in	in	IN
cord-017917-7aeh6quc	8	13	degradation	degradation	NN
cord-017917-7aeh6quc	8	14	of	of	IN
cord-017917-7aeh6quc	8	15	the	the	DT
cord-017917-7aeh6quc	8	16	extracellular	extracellular	JJ
cord-017917-7aeh6quc	8	17	matrix	matrix	NN
cord-017917-7aeh6quc	8	18	(	(	-LRB-
cord-017917-7aeh6quc	8	19	ECM	ECM	NNP
cord-017917-7aeh6quc	8	20	)	)	-RRB-
cord-017917-7aeh6quc	8	21	.	.	.
cord-017917-7aeh6quc	9	1	During	during	IN
cord-017917-7aeh6quc	9	2	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	9	3	responses	response	NNS
cord-017917-7aeh6quc	9	4	MMPs	mmp	NNS
cord-017917-7aeh6quc	9	5	are	be	VBP
cord-017917-7aeh6quc	9	6	thought	think	VBN
cord-017917-7aeh6quc	9	7	to	to	TO
cord-017917-7aeh6quc	9	8	play	play	VB
cord-017917-7aeh6quc	9	9	a	a	DT
cord-017917-7aeh6quc	9	10	significant	significant	JJ
cord-017917-7aeh6quc	9	11	role	role	NN
cord-017917-7aeh6quc	9	12	in	in	IN
cord-017917-7aeh6quc	9	13	breaking	break	VBG
cord-017917-7aeh6quc	9	14	down	down	RP
cord-017917-7aeh6quc	9	15	the	the	DT
cord-017917-7aeh6quc	9	16	basement	basement	NN
cord-017917-7aeh6quc	9	17	membrane	membrane	NN
cord-017917-7aeh6quc	9	18	surrounding	surround	VBG
cord-017917-7aeh6quc	9	19	blood	blood	NN
cord-017917-7aeh6quc	9	20	vessels	vessel	NNS
cord-017917-7aeh6quc	9	21	as	as	RB
cord-017917-7aeh6quc	9	22	well	well	RB
cord-017917-7aeh6quc	9	23	as	as	IN
cord-017917-7aeh6quc	9	24	parenchymal	parenchymal	NN
cord-017917-7aeh6quc	9	25	ECM	ECM	NNP
cord-017917-7aeh6quc	9	26	thereby	thereby	RB
cord-017917-7aeh6quc	9	27	facilitating	facilitate	VBG
cord-017917-7aeh6quc	9	28	leukocyte	leukocyte	NN
cord-017917-7aeh6quc	9	29	infiltration	infiltration	NN
cord-017917-7aeh6quc	9	30	.	.	.
cord-017917-7aeh6quc	10	1	MMPs	mmp	NNS
cord-017917-7aeh6quc	10	2	have	have	VBP
cord-017917-7aeh6quc	10	3	also	also	RB
cord-017917-7aeh6quc	10	4	been	be	VBN
cord-017917-7aeh6quc	10	5	associated	associate	VBN
cord-017917-7aeh6quc	10	6	with	with	IN
cord-017917-7aeh6quc	10	7	activation	activation	NN
cord-017917-7aeh6quc	10	8	of	of	IN
cord-017917-7aeh6quc	10	9	chemokines	chemokine	NNS
cord-017917-7aeh6quc	10	10	and	and	CC
cord-017917-7aeh6quc	10	11	perhaps	perhaps	RB
cord-017917-7aeh6quc	10	12	more	more	RBR
cord-017917-7aeh6quc	10	13	significantly	significantly	RB
cord-017917-7aeh6quc	10	14	the	the	DT
cord-017917-7aeh6quc	10	15	degradation	degradation	NN
cord-017917-7aeh6quc	10	16	of	of	IN
cord-017917-7aeh6quc	10	17	myelin	myelin	NN
cord-017917-7aeh6quc	10	18	proteins	protein	NNS
cord-017917-7aeh6quc	10	19	and	and	CC
cord-017917-7aeh6quc	10	20	generation	generation	NN
cord-017917-7aeh6quc	10	21	of	of	IN
cord-017917-7aeh6quc	10	22	autoantigens	autoantigens	NNP
cord-017917-7aeh6quc	10	23	.	.	.
cord-017917-7aeh6quc	11	1	Recent	recent	JJ
cord-017917-7aeh6quc	11	2	examination	examination	NN
cord-017917-7aeh6quc	11	3	of	of	IN
cord-017917-7aeh6quc	11	4	MMP	MMP	NNP
cord-017917-7aeh6quc	11	5	expression	expression	NN
cord-017917-7aeh6quc	11	6	during	during	IN
cord-017917-7aeh6quc	11	7	MHV	MHV	NNP
cord-017917-7aeh6quc	11	8	infection	infection	NN
cord-017917-7aeh6quc	11	9	suggests	suggest	VBZ
cord-017917-7aeh6quc	11	10	that	that	IN
cord-017917-7aeh6quc	11	11	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	11	12	,	,	,
cord-017917-7aeh6quc	11	13	-9	-9	NNP
cord-017917-7aeh6quc	11	14	and	and	CC
cord-017917-7aeh6quc	11	15	-12	-12	NNS
cord-017917-7aeh6quc	11	16	are	be	VBP
cord-017917-7aeh6quc	11	17	involved	involve	VBN
cord-017917-7aeh6quc	11	18	in	in	IN
cord-017917-7aeh6quc	11	19	the	the	DT
cord-017917-7aeh6quc	11	20	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	11	21	response	response	NN
cord-017917-7aeh6quc	11	22	.	.	.
cord-017917-7aeh6quc	12	1	The	the	DT
cord-017917-7aeh6quc	12	2	proinflammatory	proinflammatory	JJ
cord-017917-7aeh6quc	12	3	effects	effect	NNS
cord-017917-7aeh6quc	12	4	of	of	IN
cord-017917-7aeh6quc	12	5	these	these	DT
cord-017917-7aeh6quc	12	6	MMPs	mmp	NNS
cord-017917-7aeh6quc	12	7	are	be	VBP
cord-017917-7aeh6quc	12	8	likely	likely	RB
cord-017917-7aeh6quc	12	9	tempered	temper	VBN
cord-017917-7aeh6quc	12	10	by	by	IN
cord-017917-7aeh6quc	12	11	induction	induction	NN
cord-017917-7aeh6quc	12	12	of	of	IN
cord-017917-7aeh6quc	12	13	tissue	tissue	NN
cord-017917-7aeh6quc	12	14	inhibiter	inhibiter	NN
cord-017917-7aeh6quc	12	15	of	of	IN
cord-017917-7aeh6quc	12	16	metalloproteinase-1	metalloproteinase-1	NNP
cord-017917-7aeh6quc	12	17	expression	expression	NN
cord-017917-7aeh6quc	12	18	.	.	.
cord-017917-7aeh6quc	13	1	Mouse	Mouse	NNP
cord-017917-7aeh6quc	13	2	hepatitis	hepatitis	NN
cord-017917-7aeh6quc	13	3	virus	virus	NN
cord-017917-7aeh6quc	13	4	(	(	-LRB-
cord-017917-7aeh6quc	13	5	MHV	mhv	NN
cord-017917-7aeh6quc	13	6	)	)	-RRB-
cord-017917-7aeh6quc	13	7	can	can	MD
cord-017917-7aeh6quc	13	8	cause	cause	VB
cord-017917-7aeh6quc	13	9	respiratory	respiratory	JJ
cord-017917-7aeh6quc	13	10	,	,	,
cord-017917-7aeh6quc	13	11	enteric	enteric	JJ
cord-017917-7aeh6quc	13	12	,	,	,
cord-017917-7aeh6quc	13	13	hepatic	hepatic	JJ
cord-017917-7aeh6quc	13	14	or	or	CC
cord-017917-7aeh6quc	13	15	neurologic	neurologic	JJ
cord-017917-7aeh6quc	13	16	infections	infection	NNS
cord-017917-7aeh6quc	13	17	depending	depend	VBG
cord-017917-7aeh6quc	13	18	on	on	IN
cord-017917-7aeh6quc	13	19	the	the	DT
cord-017917-7aeh6quc	13	20	viral	viral	JJ
cord-017917-7aeh6quc	13	21	strain	strain	NN
cord-017917-7aeh6quc	13	22	,	,	,
cord-017917-7aeh6quc	13	23	age	age	NN
cord-017917-7aeh6quc	13	24	of	of	IN
cord-017917-7aeh6quc	13	25	the	the	DT
cord-017917-7aeh6quc	13	26	host	host	NN
cord-017917-7aeh6quc	13	27	and	and	CC
cord-017917-7aeh6quc	13	28	route	route	NN
cord-017917-7aeh6quc	13	29	of	of	IN
cord-017917-7aeh6quc	13	30	infection	infection	NN
cord-017917-7aeh6quc	13	31	(	(	-LRB-
cord-017917-7aeh6quc	13	32	33	33	CD
cord-017917-7aeh6quc	13	33	)	)	-RRB-
cord-017917-7aeh6quc	13	34	.	.	.
cord-017917-7aeh6quc	14	1	MHV	mhv	NN
cord-017917-7aeh6quc	14	2	infection	infection	NN
cord-017917-7aeh6quc	14	3	of	of	IN
cord-017917-7aeh6quc	14	4	the	the	DT
cord-017917-7aeh6quc	14	5	central	central	JJ
cord-017917-7aeh6quc	14	6	nervous	nervous	JJ
cord-017917-7aeh6quc	14	7	system	system	NN
cord-017917-7aeh6quc	14	8	(	(	-LRB-
cord-017917-7aeh6quc	14	9	CNS	CNS	NNP
cord-017917-7aeh6quc	14	10	)	)	-RRB-
cord-017917-7aeh6quc	14	11	as	as	IN
cord-017917-7aeh6quc	14	12	a	a	DT
cord-017917-7aeh6quc	14	13	model	model	NN
cord-017917-7aeh6quc	14	14	of	of	IN
cord-017917-7aeh6quc	14	15	demyelinating	demyelinating	JJ
cord-017917-7aeh6quc	14	16	disease	disease	NN
cord-017917-7aeh6quc	14	17	has	have	VBZ
cord-017917-7aeh6quc	14	18	been	be	VBN
cord-017917-7aeh6quc	14	19	studied	study	VBN
cord-017917-7aeh6quc	14	20	extensively	extensively	RB
cord-017917-7aeh6quc	14	21	using	use	VBG
cord-017917-7aeh6quc	14	22	strains	strain	NNS
cord-017917-7aeh6quc	14	23	derived	derive	VBN
cord-017917-7aeh6quc	14	24	from	from	IN
cord-017917-7aeh6quc	14	25	either	either	CC
cord-017917-7aeh6quc	14	26	the	the	DT
cord-017917-7aeh6quc	14	27	neurotropic	neurotropic	NNP
cord-017917-7aeh6quc	14	28	JHM	JHM	NNP
cord-017917-7aeh6quc	14	29	strain	strain	VB
cord-017917-7aeh6quc	15	1	(	(	-LRB-
cord-017917-7aeh6quc	15	2	MHV	MHV	NNP
cord-017917-7aeh6quc	15	3	-	-	HYPH
cord-017917-7aeh6quc	15	4	JHM	JHM	NNP
cord-017917-7aeh6quc	15	5	;	;	:
cord-017917-7aeh6quc	15	6	MHV-4	MHV-4	NNP
cord-017917-7aeh6quc	15	7	serotype	serotype	NN
cord-017917-7aeh6quc	15	8	)	)	-RRB-
cord-017917-7aeh6quc	15	9	or	or	CC
cord-017917-7aeh6quc	15	10	the	the	DT
cord-017917-7aeh6quc	15	11	MHV	MHV	NNP
cord-017917-7aeh6quc	15	12	-	-	HYPH
cord-017917-7aeh6quc	15	13	A59	A59	NNP
cord-017917-7aeh6quc	15	14	strain	strain	NN
cord-017917-7aeh6quc	15	15	,	,	,
cord-017917-7aeh6quc	15	16	which	which	WDT
cord-017917-7aeh6quc	15	17	is	be	VBZ
cord-017917-7aeh6quc	15	18	both	both	DT
cord-017917-7aeh6quc	15	19	hepatotropic	hepatotropic	NNP
cord-017917-7aeh6quc	15	20	and	and	CC
cord-017917-7aeh6quc	15	21	neurotropic	neurotropic	NNP
cord-017917-7aeh6quc	15	22	(	(	-LRB-
cord-017917-7aeh6quc	15	23	33	33	CD
cord-017917-7aeh6quc	15	24	,	,	,
cord-017917-7aeh6quc	15	25	43	43	CD
cord-017917-7aeh6quc	15	26	)	)	-RRB-
cord-017917-7aeh6quc	15	27	.	.	.
cord-017917-7aeh6quc	16	1	As	as	IN
cord-017917-7aeh6quc	16	2	described	describe	VBN
cord-017917-7aeh6quc	16	3	by	by	IN
cord-017917-7aeh6quc	16	4	others	other	NNS
cord-017917-7aeh6quc	16	5	,	,	,
cord-017917-7aeh6quc	16	6	and	and	CC
cord-017917-7aeh6quc	16	7	ourselves	-PRON-	PRP
cord-017917-7aeh6quc	16	8	acute	acute	JJ
cord-017917-7aeh6quc	16	9	MHV	MHV	NNP
cord-017917-7aeh6quc	16	10	infection	infection	NN
cord-017917-7aeh6quc	16	11	of	of	IN
cord-017917-7aeh6quc	16	12	the	the	DT
cord-017917-7aeh6quc	16	13	CNS	CNS	NNP
cord-017917-7aeh6quc	16	14	induces	induce	VBZ
cord-017917-7aeh6quc	16	15	a	a	DT
cord-017917-7aeh6quc	16	16	potent	potent	JJ
cord-017917-7aeh6quc	16	17	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	16	18	response	response	NN
cord-017917-7aeh6quc	16	19	involving	involve	VBG
cord-017917-7aeh6quc	16	20	neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	16	21	,	,	,
cord-017917-7aeh6quc	16	22	macrophages	macrophage	NNS
cord-017917-7aeh6quc	16	23	,	,	,
cord-017917-7aeh6quc	16	24	NK	NK	NNP
cord-017917-7aeh6quc	16	25	,	,	,
cord-017917-7aeh6quc	16	26	B	B	NNP
cord-017917-7aeh6quc	16	27	and	and	CC
cord-017917-7aeh6quc	16	28	T	t	NN
cord-017917-7aeh6quc	16	29	cells	cell	NNS
cord-017917-7aeh6quc	16	30	(	(	-LRB-
cord-017917-7aeh6quc	16	31	33	33	CD
cord-017917-7aeh6quc	16	32	,	,	,
cord-017917-7aeh6quc	16	33	43	43	CD
cord-017917-7aeh6quc	16	34	,	,	,
cord-017917-7aeh6quc	16	35	52	52	CD
cord-017917-7aeh6quc	16	36	)	)	-RRB-
cord-017917-7aeh6quc	16	37	.	.	.
cord-017917-7aeh6quc	17	1	In	in	IN
cord-017917-7aeh6quc	17	2	order	order	NN
cord-017917-7aeh6quc	17	3	to	to	TO
cord-017917-7aeh6quc	17	4	reach	reach	VB
cord-017917-7aeh6quc	17	5	the	the	DT
cord-017917-7aeh6quc	17	6	site	site	NN
cord-017917-7aeh6quc	17	7	of	of	IN
cord-017917-7aeh6quc	17	8	infection	infection	NN
cord-017917-7aeh6quc	17	9	,	,	,
cord-017917-7aeh6quc	17	10	however	however	RB
cord-017917-7aeh6quc	17	11	,	,	,
cord-017917-7aeh6quc	17	12	these	these	DT
cord-017917-7aeh6quc	17	13	cells	cell	NNS
cord-017917-7aeh6quc	17	14	must	must	MD
cord-017917-7aeh6quc	17	15	overcome	overcome	VB
cord-017917-7aeh6quc	17	16	physical	physical	JJ
cord-017917-7aeh6quc	17	17	barriers	barrier	NNS
cord-017917-7aeh6quc	17	18	represented	represent	VBN
cord-017917-7aeh6quc	17	19	by	by	IN
cord-017917-7aeh6quc	17	20	the	the	DT
cord-017917-7aeh6quc	17	21	blood	blood	NN
cord-017917-7aeh6quc	17	22	brain	brain	NN
cord-017917-7aeh6quc	17	23	barrier	barrier	NN
cord-017917-7aeh6quc	17	24	as	as	RB
cord-017917-7aeh6quc	17	25	well	well	RB
cord-017917-7aeh6quc	17	26	as	as	IN
cord-017917-7aeh6quc	17	27	the	the	DT
cord-017917-7aeh6quc	17	28	dense	dense	JJ
cord-017917-7aeh6quc	17	29	extracellular	extracellular	JJ
cord-017917-7aeh6quc	17	30	matrix	matrix	NN
cord-017917-7aeh6quc	17	31	(	(	-LRB-
cord-017917-7aeh6quc	17	32	ECM	ECM	NNP
cord-017917-7aeh6quc	17	33	)	)	-RRB-
cord-017917-7aeh6quc	17	34	of	of	IN
cord-017917-7aeh6quc	17	35	the	the	DT
cord-017917-7aeh6quc	17	36	CNS	CNS	NNP
cord-017917-7aeh6quc	17	37	parenchyma	parenchyma	NN
cord-017917-7aeh6quc	17	38	.	.	.
cord-017917-7aeh6quc	18	1	The	the	DT
cord-017917-7aeh6quc	18	2	ability	ability	NN
cord-017917-7aeh6quc	18	3	of	of	IN
cord-017917-7aeh6quc	18	4	leukocytes	leukocyte	NNS
cord-017917-7aeh6quc	18	5	to	to	TO
cord-017917-7aeh6quc	18	6	extravasate	extravasate	VB
cord-017917-7aeh6quc	18	7	from	from	IN
cord-017917-7aeh6quc	18	8	blood	blood	NN
cord-017917-7aeh6quc	18	9	vessels	vessel	NNS
cord-017917-7aeh6quc	18	10	and	and	CC
cord-017917-7aeh6quc	18	11	cross	cross	VB
cord-017917-7aeh6quc	18	12	the	the	DT
cord-017917-7aeh6quc	18	13	parenchymal	parenchymal	NN
cord-017917-7aeh6quc	18	14	tissues	tissue	NNS
cord-017917-7aeh6quc	18	15	is	be	VBZ
cord-017917-7aeh6quc	18	16	presumably	presumably	RB
cord-017917-7aeh6quc	18	17	dependent	dependent	JJ
cord-017917-7aeh6quc	18	18	on	on	IN
cord-017917-7aeh6quc	18	19	the	the	DT
cord-017917-7aeh6quc	18	20	activity	activity	NN
cord-017917-7aeh6quc	18	21	of	of	IN
cord-017917-7aeh6quc	18	22	extracellular	extracellular	JJ
cord-017917-7aeh6quc	18	23	proteases	protease	NNS
cord-017917-7aeh6quc	18	24	.	.	.
cord-017917-7aeh6quc	19	1	One	one	CD
cord-017917-7aeh6quc	19	2	family	family	NN
cord-017917-7aeh6quc	19	3	of	of	IN
cord-017917-7aeh6quc	19	4	proteases	protease	NNS
cord-017917-7aeh6quc	19	5	,	,	,
cord-017917-7aeh6quc	19	6	which	which	WDT
cord-017917-7aeh6quc	19	7	are	be	VBP
cord-017917-7aeh6quc	19	8	often	often	RB
cord-017917-7aeh6quc	19	9	associated	associate	VBN
cord-017917-7aeh6quc	19	10	with	with	IN
cord-017917-7aeh6quc	19	11	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	19	12	responses	response	NNS
cord-017917-7aeh6quc	19	13	are	be	VBP
cord-017917-7aeh6quc	19	14	the	the	DT
cord-017917-7aeh6quc	19	15	matrix	matrix	NN
cord-017917-7aeh6quc	19	16	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	19	17	(	(	-LRB-
cord-017917-7aeh6quc	19	18	MMPs	MMPs	NNP
cord-017917-7aeh6quc	19	19	)	)	-RRB-
cord-017917-7aeh6quc	19	20	.	.	.
cord-017917-7aeh6quc	20	1	The	the	DT
cord-017917-7aeh6quc	20	2	descriptions	description	NNS
cord-017917-7aeh6quc	20	3	of	of	IN
cord-017917-7aeh6quc	20	4	MMP	MMP	NNP
cord-017917-7aeh6quc	20	5	regulation	regulation	NN
cord-017917-7aeh6quc	20	6	and	and	CC
cord-017917-7aeh6quc	20	7	function	function	NN
cord-017917-7aeh6quc	20	8	during	during	IN
cord-017917-7aeh6quc	20	9	normal	normal	JJ
cord-017917-7aeh6quc	20	10	physiological	physiological	JJ
cord-017917-7aeh6quc	20	11	as	as	RB
cord-017917-7aeh6quc	20	12	well	well	RB
cord-017917-7aeh6quc	20	13	as	as	IN
cord-017917-7aeh6quc	20	14	pathological	pathological	JJ
cord-017917-7aeh6quc	20	15	conditions	condition	NNS
cord-017917-7aeh6quc	20	16	have	have	VBP
cord-017917-7aeh6quc	20	17	been	be	VBN
cord-017917-7aeh6quc	20	18	described	describe	VBN
cord-017917-7aeh6quc	20	19	in	in	IN
cord-017917-7aeh6quc	20	20	numerous	numerous	JJ
cord-017917-7aeh6quc	20	21	publications	publication	NNS
cord-017917-7aeh6quc	20	22	(	(	-LRB-
cord-017917-7aeh6quc	20	23	32	32	CD
cord-017917-7aeh6quc	20	24	,	,	,
cord-017917-7aeh6quc	20	25	23	23	CD
cord-017917-7aeh6quc	20	26	,	,	,
cord-017917-7aeh6quc	20	27	41	41	CD
cord-017917-7aeh6quc	20	28	)	)	-RRB-
cord-017917-7aeh6quc	20	29	,	,	,
cord-017917-7aeh6quc	20	30	thus	thus	RB
cord-017917-7aeh6quc	20	31	only	only	RB
cord-017917-7aeh6quc	20	32	a	a	DT
cord-017917-7aeh6quc	20	33	brief	brief	JJ
cord-017917-7aeh6quc	20	34	summary	summary	NN
cord-017917-7aeh6quc	20	35	is	be	VBZ
cord-017917-7aeh6quc	20	36	provided	provide	VBN
cord-017917-7aeh6quc	20	37	herein	herein	RB
cord-017917-7aeh6quc	20	38	.	.	.
cord-017917-7aeh6quc	21	1	MMPs	MMPs	NNP
cord-017917-7aeh6quc	21	2	comprise	comprise	VBP
cord-017917-7aeh6quc	21	3	a	a	DT
cord-017917-7aeh6quc	21	4	large	large	JJ
cord-017917-7aeh6quc	21	5	group	group	NN
cord-017917-7aeh6quc	21	6	of	of	IN
cord-017917-7aeh6quc	21	7	endoproteinases	endoproteinase	NNS
cord-017917-7aeh6quc	21	8	that	that	WDT
cord-017917-7aeh6quc	21	9	,	,	,
cord-017917-7aeh6quc	21	10	in	in	IN
cord-017917-7aeh6quc	21	11	conjunction	conjunction	NN
cord-017917-7aeh6quc	21	12	with	with	IN
cord-017917-7aeh6quc	21	13	other	other	JJ
cord-017917-7aeh6quc	21	14	proteases	protease	NNS
cord-017917-7aeh6quc	21	15	,	,	,
cord-017917-7aeh6quc	21	16	mediate	mediate	VB
cord-017917-7aeh6quc	21	17	degradation	degradation	NN
cord-017917-7aeh6quc	21	18	during	during	IN
cord-017917-7aeh6quc	21	19	remodeling	remodeling	NN
cord-017917-7aeh6quc	21	20	of	of	IN
cord-017917-7aeh6quc	21	21	the	the	DT
cord-017917-7aeh6quc	21	22	extracellular	extracellular	JJ
cord-017917-7aeh6quc	21	23	matrix	matrix	NN
cord-017917-7aeh6quc	21	24	(	(	-LRB-
cord-017917-7aeh6quc	21	25	ECM	ECM	NNP
cord-017917-7aeh6quc	21	26	)	)	-RRB-
cord-017917-7aeh6quc	21	27	.	.	.
cord-017917-7aeh6quc	22	1	Twenty	twenty	CD
cord-017917-7aeh6quc	22	2	four	four	CD
cord-017917-7aeh6quc	22	3	different	different	JJ
cord-017917-7aeh6quc	22	4	MMPs	mmp	NNS
cord-017917-7aeh6quc	22	5	have	have	VBP
cord-017917-7aeh6quc	22	6	been	be	VBN
cord-017917-7aeh6quc	22	7	identified	identify	VBN
cord-017917-7aeh6quc	22	8	and	and	CC
cord-017917-7aeh6quc	22	9	classified	classify	VBN
cord-017917-7aeh6quc	22	10	as	as	IN
cord-017917-7aeh6quc	22	11	collagenases	collagenases	NNP
cord-017917-7aeh6quc	22	12	,	,	,
cord-017917-7aeh6quc	22	13	gelatinases	gelatinases	NNP
cord-017917-7aeh6quc	22	14	,	,	,
cord-017917-7aeh6quc	22	15	stromelysins	stromelysins	NNP
cord-017917-7aeh6quc	22	16	,	,	,
cord-017917-7aeh6quc	22	17	matrilysin	matrilysin	NNP
cord-017917-7aeh6quc	22	18	and	and	CC
cord-017917-7aeh6quc	22	19	membrane	membrane	NN
cord-017917-7aeh6quc	22	20	type	type	NN
cord-017917-7aeh6quc	22	21	MMPs	mmp	NNS
cord-017917-7aeh6quc	22	22	(	(	-LRB-
cord-017917-7aeh6quc	22	23	MT	MT	NNP
cord-017917-7aeh6quc	22	24	-	-	HYPH
cord-017917-7aeh6quc	22	25	MMPs	MMPs	NNP
cord-017917-7aeh6quc	22	26	)	)	-RRB-
cord-017917-7aeh6quc	22	27	based	base	VBN
cord-017917-7aeh6quc	22	28	on	on	IN
cord-017917-7aeh6quc	22	29	their	-PRON-	PRP$
cord-017917-7aeh6quc	22	30	substrate	substrate	NN
cord-017917-7aeh6quc	22	31	specificities	specificity	NNS
cord-017917-7aeh6quc	22	32	and	and	CC
cord-017917-7aeh6quc	22	33	protein	protein	NN
cord-017917-7aeh6quc	22	34	domain	domain	NN
cord-017917-7aeh6quc	22	35	structures	structure	NNS
cord-017917-7aeh6quc	22	36	(	(	-LRB-
cord-017917-7aeh6quc	22	37	24,34	24,34	CD
cord-017917-7aeh6quc	22	38	)	)	-RRB-
cord-017917-7aeh6quc	22	39	.	.	.
cord-017917-7aeh6quc	23	1	These	these	DT
cord-017917-7aeh6quc	23	2	proteases	protease	NNS
cord-017917-7aeh6quc	23	3	are	be	VBP
cord-017917-7aeh6quc	23	4	produced	produce	VBN
cord-017917-7aeh6quc	23	5	by	by	IN
cord-017917-7aeh6quc	23	6	a	a	DT
cord-017917-7aeh6quc	23	7	wide	wide	JJ
cord-017917-7aeh6quc	23	8	range	range	NN
cord-017917-7aeh6quc	23	9	of	of	IN
cord-017917-7aeh6quc	23	10	cell	cell	NN
cord-017917-7aeh6quc	23	11	types	type	NNS
cord-017917-7aeh6quc	23	12	,	,	,
cord-017917-7aeh6quc	23	13	including	include	VBG
cord-017917-7aeh6quc	23	14	endothelial	endothelial	JJ
cord-017917-7aeh6quc	23	15	,	,	,
cord-017917-7aeh6quc	23	16	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	23	17	and	and	CC
cord-017917-7aeh6quc	23	18	stromal	stromal	JJ
cord-017917-7aeh6quc	23	19	cells	cell	NNS
cord-017917-7aeh6quc	23	20	(	(	-LRB-
cord-017917-7aeh6quc	23	21	18	18	CD
cord-017917-7aeh6quc	23	22	,	,	,
cord-017917-7aeh6quc	23	23	23	23	CD
cord-017917-7aeh6quc	23	24	,	,	,
cord-017917-7aeh6quc	23	25	32	32	CD
cord-017917-7aeh6quc	23	26	)	)	-RRB-
cord-017917-7aeh6quc	23	27	.	.	.
cord-017917-7aeh6quc	24	1	Regulation	regulation	NN
cord-017917-7aeh6quc	24	2	of	of	IN
cord-017917-7aeh6quc	24	3	MMP	MMP	NNP
cord-017917-7aeh6quc	24	4	activity	activity	NN
cord-017917-7aeh6quc	24	5	has	have	VBZ
cord-017917-7aeh6quc	24	6	been	be	VBN
cord-017917-7aeh6quc	24	7	classically	classically	RB
cord-017917-7aeh6quc	24	8	defined	define	VBN
cord-017917-7aeh6quc	24	9	as	as	IN
cord-017917-7aeh6quc	24	10	occurring	occur	VBG
cord-017917-7aeh6quc	24	11	at	at	IN
cord-017917-7aeh6quc	24	12	three	three	CD
cord-017917-7aeh6quc	24	13	distinct	distinct	JJ
cord-017917-7aeh6quc	24	14	levels	level	NNS
cord-017917-7aeh6quc	24	15	.	.	.
cord-017917-7aeh6quc	25	1	Primary	primary	JJ
cord-017917-7aeh6quc	25	2	regulation	regulation	NN
cord-017917-7aeh6quc	25	3	of	of	IN
cord-017917-7aeh6quc	25	4	MMP	MMP	NNP
cord-017917-7aeh6quc	25	5	activity	activity	NN
cord-017917-7aeh6quc	25	6	occurs	occur	VBZ
cord-017917-7aeh6quc	25	7	at	at	IN
cord-017917-7aeh6quc	25	8	the	the	DT
cord-017917-7aeh6quc	25	9	transcriptional	transcriptional	JJ
cord-017917-7aeh6quc	25	10	level	level	NN
cord-017917-7aeh6quc	25	11	(	(	-LRB-
cord-017917-7aeh6quc	25	12	5	5	CD
cord-017917-7aeh6quc	25	13	,	,	,
cord-017917-7aeh6quc	25	14	12	12	CD
cord-017917-7aeh6quc	25	15	,	,	,
cord-017917-7aeh6quc	25	16	22	22	CD
cord-017917-7aeh6quc	25	17	,	,	,
cord-017917-7aeh6quc	25	18	30	30	CD
cord-017917-7aeh6quc	25	19	,	,	,
cord-017917-7aeh6quc	25	20	40	40	CD
cord-017917-7aeh6quc	25	21	)	)	-RRB-
cord-017917-7aeh6quc	25	22	.	.	.
cord-017917-7aeh6quc	26	1	MMP	MMP	NNP
cord-017917-7aeh6quc	26	2	gene	gene	NN
cord-017917-7aeh6quc	26	3	expression	expression	NN
cord-017917-7aeh6quc	26	4	can	can	MD
cord-017917-7aeh6quc	26	5	be	be	VB
cord-017917-7aeh6quc	26	6	induced	induce	VBN
cord-017917-7aeh6quc	26	7	by	by	IN
cord-017917-7aeh6quc	26	8	a	a	DT
cord-017917-7aeh6quc	26	9	wide	wide	JJ
cord-017917-7aeh6quc	26	10	range	range	NN
cord-017917-7aeh6quc	26	11	of	of	IN
cord-017917-7aeh6quc	26	12	signals	signal	NNS
cord-017917-7aeh6quc	26	13	including	include	VBG
cord-017917-7aeh6quc	26	14	acute	acute	JJ
cord-017917-7aeh6quc	26	15	phase	phase	NN
cord-017917-7aeh6quc	26	16	cytokines	cytokine	NNS
cord-017917-7aeh6quc	26	17	such	such	JJ
cord-017917-7aeh6quc	26	18	as	as	IN
cord-017917-7aeh6quc	26	19	IL	IL	NNP
cord-017917-7aeh6quc	26	20	-	-	HYPH
cord-017917-7aeh6quc	26	21	lc~	lc~	NN
cord-017917-7aeh6quc	26	22	and	and	CC
cord-017917-7aeh6quc	26	23	-13	-13	NNS
cord-017917-7aeh6quc	26	24	,	,	,
cord-017917-7aeh6quc	26	25	IL-6	IL-6	NNP
cord-017917-7aeh6quc	26	26	and	and	CC
cord-017917-7aeh6quc	26	27	TNF	TNF	NNP
cord-017917-7aeh6quc	26	28	-	-	HYPH
cord-017917-7aeh6quc	26	29	c~	c~	NNP
cord-017917-7aeh6quc	26	30	,	,	,
cord-017917-7aeh6quc	26	31	and	and	CC
cord-017917-7aeh6quc	26	32	chemokines	chemokine	NNS
cord-017917-7aeh6quc	26	33	such	such	JJ
cord-017917-7aeh6quc	26	34	as	as	IN
cord-017917-7aeh6quc	26	35	MIP113	MIP113	NNP
cord-017917-7aeh6quc	26	36	,	,	,
cord-017917-7aeh6quc	26	37	and	and	CC
cord-017917-7aeh6quc	26	38	RANTES	RANTES	NNP
cord-017917-7aeh6quc	26	39	(	(	-LRB-
cord-017917-7aeh6quc	26	40	6	6	CD
cord-017917-7aeh6quc	26	41	,	,	,
cord-017917-7aeh6quc	26	42	12	12	CD
cord-017917-7aeh6quc	26	43	,	,	,
cord-017917-7aeh6quc	26	44	22	22	CD
cord-017917-7aeh6quc	26	45	)	)	-RRB-
cord-017917-7aeh6quc	26	46	.	.	.
cord-017917-7aeh6quc	27	1	A	a	DT
cord-017917-7aeh6quc	27	2	second	second	JJ
cord-017917-7aeh6quc	27	3	level	level	NN
cord-017917-7aeh6quc	27	4	of	of	IN
cord-017917-7aeh6quc	27	5	regulation	regulation	NN
cord-017917-7aeh6quc	27	6	for	for	IN
cord-017917-7aeh6quc	27	7	MMP	MMP	NNP
cord-017917-7aeh6quc	27	8	activity	activity	NN
cord-017917-7aeh6quc	27	9	is	be	VBZ
cord-017917-7aeh6quc	27	10	post	post	JJ
cord-017917-7aeh6quc	27	11	-	-	JJ
cord-017917-7aeh6quc	27	12	translational	translational	JJ
cord-017917-7aeh6quc	27	13	,	,	,
cord-017917-7aeh6quc	27	14	as	as	IN
cord-017917-7aeh6quc	27	15	MMPs	mmp	NNS
cord-017917-7aeh6quc	27	16	require	require	VBP
cord-017917-7aeh6quc	27	17	proteolytic	proteolytic	JJ
cord-017917-7aeh6quc	27	18	cleavage	cleavage	NN
cord-017917-7aeh6quc	27	19	of	of	IN
cord-017917-7aeh6quc	27	20	their	-PRON-	PRP$
cord-017917-7aeh6quc	27	21	proenzyme	proenzyme	NNS
cord-017917-7aeh6quc	27	22	form	form	NN
cord-017917-7aeh6quc	27	23	to	to	TO
cord-017917-7aeh6quc	27	24	become	become	VB
cord-017917-7aeh6quc	27	25	activated	activate	VBN
cord-017917-7aeh6quc	27	26	(	(	-LRB-
cord-017917-7aeh6quc	27	27	4,34	4,34	CD
cord-017917-7aeh6quc	27	28	)	)	-RRB-
cord-017917-7aeh6quc	27	29	.	.	.
cord-017917-7aeh6quc	28	1	Following	follow	VBG
cord-017917-7aeh6quc	28	2	translation	translation	NN
cord-017917-7aeh6quc	28	3	,	,	,
cord-017917-7aeh6quc	28	4	most	most	JJS
cord-017917-7aeh6quc	28	5	proMMPs	proMMPs	NNP
cord-017917-7aeh6quc	28	6	are	be	VBP
cord-017917-7aeh6quc	28	7	released	release	VBN
cord-017917-7aeh6quc	28	8	into	into	IN
cord-017917-7aeh6quc	28	9	the	the	DT
cord-017917-7aeh6quc	28	10	extracellular	extracellular	JJ
cord-017917-7aeh6quc	28	11	space	space	NN
cord-017917-7aeh6quc	28	12	.	.	.
cord-017917-7aeh6quc	29	1	By	by	IN
cord-017917-7aeh6quc	29	2	contrast	contrast	NN
cord-017917-7aeh6quc	29	3	,	,	,
cord-017917-7aeh6quc	29	4	a	a	DT
cord-017917-7aeh6quc	29	5	subgroup	subgroup	NN
cord-017917-7aeh6quc	29	6	of	of	IN
cord-017917-7aeh6quc	29	7	membrane	membrane	NN
cord-017917-7aeh6quc	29	8	associated	associate	VBD
cord-017917-7aeh6quc	29	9	MMPs	MMPs	NNP
cord-017917-7aeh6quc	29	10	,	,	,
cord-017917-7aeh6quc	29	11	the	the	DT
cord-017917-7aeh6quc	29	12	MT	MT	NNP
cord-017917-7aeh6quc	29	13	-	-	HYPH
cord-017917-7aeh6quc	29	14	MMPs	MMPs	NNP
cord-017917-7aeh6quc	29	15	,	,	,
cord-017917-7aeh6quc	29	16	may	may	MD
cord-017917-7aeh6quc	29	17	play	play	VB
cord-017917-7aeh6quc	29	18	a	a	DT
cord-017917-7aeh6quc	29	19	role	role	NN
cord-017917-7aeh6quc	29	20	in	in	IN
cord-017917-7aeh6quc	29	21	the	the	DT
cord-017917-7aeh6quc	29	22	processing	processing	NN
cord-017917-7aeh6quc	29	23	of	of	IN
cord-017917-7aeh6quc	29	24	secreted	secrete	VBN
cord-017917-7aeh6quc	29	25	proMMPs	proMMPs	NNP
cord-017917-7aeh6quc	29	26	to	to	IN
cord-017917-7aeh6quc	29	27	their	-PRON-	PRP$
cord-017917-7aeh6quc	29	28	active	active	JJ
cord-017917-7aeh6quc	29	29	form	form	NN
cord-017917-7aeh6quc	29	30	(	(	-LRB-
cord-017917-7aeh6quc	29	31	20	20	CD
cord-017917-7aeh6quc	29	32	)	)	-RRB-
cord-017917-7aeh6quc	29	33	.	.	.
cord-017917-7aeh6quc	30	1	The	the	DT
cord-017917-7aeh6quc	30	2	final	final	JJ
cord-017917-7aeh6quc	30	3	level	level	NN
cord-017917-7aeh6quc	30	4	of	of	IN
cord-017917-7aeh6quc	30	5	control	control	NN
cord-017917-7aeh6quc	30	6	for	for	IN
cord-017917-7aeh6quc	30	7	MMP	MMP	NNP
cord-017917-7aeh6quc	30	8	activity	activity	NN
cord-017917-7aeh6quc	30	9	resides	reside	VBZ
cord-017917-7aeh6quc	30	10	in	in	IN
cord-017917-7aeh6quc	30	11	their	-PRON-	PRP$
cord-017917-7aeh6quc	30	12	regulation	regulation	NN
cord-017917-7aeh6quc	30	13	by	by	IN
cord-017917-7aeh6quc	30	14	a	a	DT
cord-017917-7aeh6quc	30	15	small	small	JJ
cord-017917-7aeh6quc	30	16	group	group	NN
cord-017917-7aeh6quc	30	17	of	of	IN
cord-017917-7aeh6quc	30	18	specific	specific	JJ
cord-017917-7aeh6quc	30	19	inhibitors	inhibitor	NNS
cord-017917-7aeh6quc	30	20	,	,	,
cord-017917-7aeh6quc	30	21	the	the	DT
cord-017917-7aeh6quc	30	22	tissue	tissue	NN
cord-017917-7aeh6quc	30	23	inhibitors	inhibitor	NNS
cord-017917-7aeh6quc	30	24	of	of	IN
cord-017917-7aeh6quc	30	25	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	30	26	(	(	-LRB-
cord-017917-7aeh6quc	30	27	TIMPs	TIMPs	NNP
cord-017917-7aeh6quc	30	28	)	)	-RRB-
cord-017917-7aeh6quc	30	29	(	(	-LRB-
cord-017917-7aeh6quc	30	30	7	7	CD
cord-017917-7aeh6quc	30	31	)	)	-RRB-
cord-017917-7aeh6quc	30	32	.	.	.
cord-017917-7aeh6quc	31	1	TIMPs	TIMPs	NNP
cord-017917-7aeh6quc	31	2	function	function	NN
cord-017917-7aeh6quc	31	3	primarily	primarily	RB
cord-017917-7aeh6quc	31	4	as	as	IN
cord-017917-7aeh6quc	31	5	specific	specific	JJ
cord-017917-7aeh6quc	31	6	inhibiters	inhibiter	NNS
cord-017917-7aeh6quc	31	7	,	,	,
cord-017917-7aeh6quc	31	8	binding	bind	VBG
cord-017917-7aeh6quc	31	9	to	to	IN
cord-017917-7aeh6quc	31	10	MMPs	mmp	NNS
cord-017917-7aeh6quc	31	11	in	in	IN
cord-017917-7aeh6quc	31	12	a	a	DT
cord-017917-7aeh6quc	31	13	1:1	1:1	CD
cord-017917-7aeh6quc	31	14	stoicheometry	stoicheometry	NN
cord-017917-7aeh6quc	31	15	.	.	.
cord-017917-7aeh6quc	32	1	Interestingly	interestingly	RB
cord-017917-7aeh6quc	32	2	,	,	,
cord-017917-7aeh6quc	32	3	there	there	EX
cord-017917-7aeh6quc	32	4	is	be	VBZ
cord-017917-7aeh6quc	32	5	evidence	evidence	NN
cord-017917-7aeh6quc	32	6	that	that	IN
cord-017917-7aeh6quc	32	7	TIMPs	TIMPs	NNP
cord-017917-7aeh6quc	32	8	may	may	MD
cord-017917-7aeh6quc	32	9	also	also	RB
cord-017917-7aeh6quc	32	10	act	act	VB
cord-017917-7aeh6quc	32	11	as	as	IN
cord-017917-7aeh6quc	32	12	chaperone	chaperone	NN
cord-017917-7aeh6quc	32	13	proteins	protein	NNS
cord-017917-7aeh6quc	32	14	during	during	IN
cord-017917-7aeh6quc	32	15	the	the	DT
cord-017917-7aeh6quc	32	16	processing	processing	NN
cord-017917-7aeh6quc	32	17	of	of	IN
cord-017917-7aeh6quc	32	18	MMPs	mmp	NNS
cord-017917-7aeh6quc	32	19	from	from	IN
cord-017917-7aeh6quc	32	20	proenzyme	proenzyme	NNS
cord-017917-7aeh6quc	32	21	to	to	IN
cord-017917-7aeh6quc	32	22	active	active	JJ
cord-017917-7aeh6quc	32	23	form	form	NN
cord-017917-7aeh6quc	32	24	,	,	,
cord-017917-7aeh6quc	32	25	suggesting	suggest	VBG
cord-017917-7aeh6quc	32	26	that	that	IN
cord-017917-7aeh6quc	32	27	they	-PRON-	PRP
cord-017917-7aeh6quc	32	28	can	can	MD
cord-017917-7aeh6quc	32	29	promote	promote	VB
cord-017917-7aeh6quc	32	30	as	as	RB
cord-017917-7aeh6quc	32	31	well	well	RB
cord-017917-7aeh6quc	32	32	as	as	IN
cord-017917-7aeh6quc	32	33	inhibit	inhibit	NN
cord-017917-7aeh6quc	32	34	MMP	MMP	NNP
cord-017917-7aeh6quc	32	35	enzymatic	enzymatic	JJ
cord-017917-7aeh6quc	32	36	activity	activity	NN
cord-017917-7aeh6quc	32	37	,	,	,
cord-017917-7aeh6quc	32	38	at	at	IN
cord-017917-7aeh6quc	32	39	least	least	JJS
cord-017917-7aeh6quc	32	40	for	for	IN
cord-017917-7aeh6quc	32	41	44	44	CD
cord-017917-7aeh6quc	32	42	)	)	-RRB-
cord-017917-7aeh6quc	32	43	.	.	.
cord-017917-7aeh6quc	33	1	MMPs	MMPs	NNP
cord-017917-7aeh6quc	33	2	and	and	CC
cord-017917-7aeh6quc	33	3	their	-PRON-	PRP$
cord-017917-7aeh6quc	33	4	inhibitors	inhibitor	NNS
cord-017917-7aeh6quc	33	5	are	be	VBP
cord-017917-7aeh6quc	33	6	involved	involve	VBN
cord-017917-7aeh6quc	33	7	in	in	IN
cord-017917-7aeh6quc	33	8	remodeling	remodeling	NN
cord-017917-7aeh6quc	33	9	of	of	IN
cord-017917-7aeh6quc	33	10	the	the	DT
cord-017917-7aeh6quc	33	11	ECM	ECM	NNP
cord-017917-7aeh6quc	33	12	during	during	IN
cord-017917-7aeh6quc	33	13	normal	normal	JJ
cord-017917-7aeh6quc	33	14	physiological	physiological	JJ
cord-017917-7aeh6quc	33	15	conditions	condition	NNS
cord-017917-7aeh6quc	33	16	.	.	.
cord-017917-7aeh6quc	34	1	However	however	RB
cord-017917-7aeh6quc	34	2	they	-PRON-	PRP
cord-017917-7aeh6quc	34	3	have	have	VBP
cord-017917-7aeh6quc	34	4	also	also	RB
cord-017917-7aeh6quc	34	5	been	be	VBN
cord-017917-7aeh6quc	34	6	associated	associate	VBN
cord-017917-7aeh6quc	34	7	with	with	IN
cord-017917-7aeh6quc	34	8	diverse	diverse	JJ
cord-017917-7aeh6quc	34	9	pathological	pathological	JJ
cord-017917-7aeh6quc	34	10	processes	process	NNS
cord-017917-7aeh6quc	34	11	from	from	IN
cord-017917-7aeh6quc	34	12	rheumatoid	rheumatoid	JJ
cord-017917-7aeh6quc	34	13	arthritis	arthritis	NN
cord-017917-7aeh6quc	34	14	to	to	TO
cord-017917-7aeh6quc	34	15	tumor	tumor	NN
cord-017917-7aeh6quc	34	16	invasion	invasion	NN
cord-017917-7aeh6quc	34	17	and	and	CC
cord-017917-7aeh6quc	34	18	metastasis	metastasis	NN
cord-017917-7aeh6quc	34	19	(	(	-LRB-
cord-017917-7aeh6quc	34	20	16	16	CD
cord-017917-7aeh6quc	34	21	,	,	,
cord-017917-7aeh6quc	34	22	25	25	CD
cord-017917-7aeh6quc	34	23	)	)	-RRB-
cord-017917-7aeh6quc	34	24	.	.	.
cord-017917-7aeh6quc	35	1	A	a	DT
cord-017917-7aeh6quc	35	2	number	number	NN
cord-017917-7aeh6quc	35	3	of	of	IN
cord-017917-7aeh6quc	35	4	MMPs	mmp	NNS
cord-017917-7aeh6quc	35	5	and	and	CC
cord-017917-7aeh6quc	35	6	TIMPs	TIMPs	NNP
cord-017917-7aeh6quc	35	7	have	have	VBP
cord-017917-7aeh6quc	35	8	also	also	RB
cord-017917-7aeh6quc	35	9	been	be	VBN
cord-017917-7aeh6quc	35	10	associated	associate	VBN
cord-017917-7aeh6quc	35	11	with	with	IN
cord-017917-7aeh6quc	35	12	the	the	DT
cord-017917-7aeh6quc	35	13	CNS	CNS	NNP
cord-017917-7aeh6quc	35	14	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	35	15	/	/	SYM
cord-017917-7aeh6quc	35	16	demyelinating	demyelinate	VBG
cord-017917-7aeh6quc	35	17	disease	disease	NN
cord-017917-7aeh6quc	35	18	multiple	multiple	JJ
cord-017917-7aeh6quc	35	19	sclerosis	sclerosis	NNP
cord-017917-7aeh6quc	35	20	(	(	-LRB-
cord-017917-7aeh6quc	35	21	MS	MS	NNP
cord-017917-7aeh6quc	35	22	)	)	-RRB-
cord-017917-7aeh6quc	35	23	in	in	IN
cord-017917-7aeh6quc	35	24	humans	human	NNS
cord-017917-7aeh6quc	35	25	(	(	-LRB-
cord-017917-7aeh6quc	35	26	2,32	2,32	LS
cord-017917-7aeh6quc	35	27	)	)	-RRB-
cord-017917-7aeh6quc	35	28	as	as	RB
cord-017917-7aeh6quc	35	29	well	well	RB
cord-017917-7aeh6quc	35	30	as	as	IN
cord-017917-7aeh6quc	35	31	its	-PRON-	PRP$
cord-017917-7aeh6quc	35	32	rodent	rodent	NN
cord-017917-7aeh6quc	35	33	model	model	NN
cord-017917-7aeh6quc	35	34	experimental	experimental	JJ
cord-017917-7aeh6quc	35	35	autoimmune	autoimmune	NN
cord-017917-7aeh6quc	35	36	encephalitis	encephalitis	RB
cord-017917-7aeh6quc	35	37	(	(	-LRB-
cord-017917-7aeh6quc	35	38	EAE	EAE	NNP
cord-017917-7aeh6quc	35	39	)	)	-RRB-
cord-017917-7aeh6quc	35	40	(	(	-LRB-
cord-017917-7aeh6quc	35	41	10,38	10,38	CD
cord-017917-7aeh6quc	35	42	)	)	-RRB-
cord-017917-7aeh6quc	35	43	.	.	.
cord-017917-7aeh6quc	36	1	In	in	IN
cord-017917-7aeh6quc	36	2	the	the	DT
cord-017917-7aeh6quc	36	3	case	case	NN
cord-017917-7aeh6quc	36	4	of	of	IN
cord-017917-7aeh6quc	36	5	MS	MS	NNP
cord-017917-7aeh6quc	36	6	,	,	,
cord-017917-7aeh6quc	36	7	these	these	DT
cord-017917-7aeh6quc	36	8	include	include	VBP
cord-017917-7aeh6quc	36	9	MMP-1	MMP-1	NNP
cord-017917-7aeh6quc	36	10	,	,	,
cord-017917-7aeh6quc	36	11	-2	-2	NNP
cord-017917-7aeh6quc	36	12	,	,	,
cord-017917-7aeh6quc	36	13	-3	-3	NNP
cord-017917-7aeh6quc	36	14	-7	-7	NNP
cord-017917-7aeh6quc	36	15	and	and	CC
cord-017917-7aeh6quc	36	16	-9	-9	NNP
cord-017917-7aeh6quc	36	17	and	and	CC
cord-017917-7aeh6quc	36	18	TLMP-1	TLMP-1	NNP
cord-017917-7aeh6quc	36	19	(	(	-LRB-
cord-017917-7aeh6quc	36	20	2,11,32	2,11,32	CD
cord-017917-7aeh6quc	36	21	)	)	-RRB-
cord-017917-7aeh6quc	36	22	.	.	.
cord-017917-7aeh6quc	37	1	These	these	DT
cord-017917-7aeh6quc	37	2	MMPs	mmp	NNS
cord-017917-7aeh6quc	37	3	and	and	CC
cord-017917-7aeh6quc	37	4	TIMPs	timp	NNS
cord-017917-7aeh6quc	37	5	have	have	VBP
cord-017917-7aeh6quc	37	6	been	be	VBN
cord-017917-7aeh6quc	37	7	detected	detect	VBN
cord-017917-7aeh6quc	37	8	by	by	IN
cord-017917-7aeh6quc	37	9	immunohistochemistry	immunohistochemistry	NN
cord-017917-7aeh6quc	37	10	in	in	IN
cord-017917-7aeh6quc	37	11	both	both	DT
cord-017917-7aeh6quc	37	12	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	37	13	infiltrates	infiltrate	NNS
cord-017917-7aeh6quc	37	14	and	and	CC
cord-017917-7aeh6quc	37	15	activated	activate	VBD
cord-017917-7aeh6quc	37	16	glia	glia	NNS
cord-017917-7aeh6quc	37	17	within	within	IN
cord-017917-7aeh6quc	37	18	acute	acute	JJ
cord-017917-7aeh6quc	37	19	MS	MS	NNP
cord-017917-7aeh6quc	37	20	lesions	lesion	NNS
cord-017917-7aeh6quc	37	21	as	as	RB
cord-017917-7aeh6quc	37	22	well	well	RB
cord-017917-7aeh6quc	37	23	as	as	IN
cord-017917-7aeh6quc	37	24	perivascular	perivascular	NNP
cord-017917-7aeh6quc	37	25	infiltrates	infiltrate	VBZ
cord-017917-7aeh6quc	37	26	.	.	.
cord-017917-7aeh6quc	38	1	Following	follow	VBG
cord-017917-7aeh6quc	38	2	EAE	EAE	NNP
cord-017917-7aeh6quc	38	3	induction	induction	NN
cord-017917-7aeh6quc	38	4	in	in	IN
cord-017917-7aeh6quc	38	5	mice	mouse	NNS
cord-017917-7aeh6quc	38	6	,	,	,
cord-017917-7aeh6quc	38	7	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	38	8	,	,	,
cord-017917-7aeh6quc	38	9	-9	-9	NNP
cord-017917-7aeh6quc	38	10	,	,	,
cord-017917-7aeh6quc	38	11	-12	-12	NN
cord-017917-7aeh6quc	38	12	and	and	CC
cord-017917-7aeh6quc	38	13	-14	-14	NN
cord-017917-7aeh6quc	38	14	as	as	RB
cord-017917-7aeh6quc	38	15	well	well	RB
cord-017917-7aeh6quc	38	16	as	as	IN
cord-017917-7aeh6quc	38	17	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	38	18	gene	gene	NN
cord-017917-7aeh6quc	38	19	expression	expression	NN
cord-017917-7aeh6quc	38	20	were	be	VBD
cord-017917-7aeh6quc	38	21	induced	induce	VBN
cord-017917-7aeh6quc	38	22	within	within	IN
cord-017917-7aeh6quc	38	23	the	the	DT
cord-017917-7aeh6quc	38	24	CNS	CNS	NNP
cord-017917-7aeh6quc	38	25	(	(	-LRB-
cord-017917-7aeh6quc	38	26	38	38	CD
cord-017917-7aeh6quc	38	27	)	)	-RRB-
cord-017917-7aeh6quc	38	28	.	.	.
cord-017917-7aeh6quc	39	1	MMP-1	MMP-1	NNP
cord-017917-7aeh6quc	39	2	and	and	CC
cord-017917-7aeh6quc	39	3	-10	-10	NNP
cord-017917-7aeh6quc	39	4	were	be	VBD
cord-017917-7aeh6quc	39	5	also	also	RB
cord-017917-7aeh6quc	39	6	induced	induce	VBN
cord-017917-7aeh6quc	39	7	although	although	IN
cord-017917-7aeh6quc	39	8	to	to	IN
cord-017917-7aeh6quc	39	9	a	a	DT
cord-017917-7aeh6quc	39	10	lesser	less	JJR
cord-017917-7aeh6quc	39	11	degree	degree	NN
cord-017917-7aeh6quc	39	12	than	than	IN
cord-017917-7aeh6quc	39	13	the	the	DT
cord-017917-7aeh6quc	39	14	aforementioned	aforementioned	JJ
cord-017917-7aeh6quc	39	15	genes	gene	NNS
cord-017917-7aeh6quc	39	16	(	(	-LRB-
cord-017917-7aeh6quc	39	17	38	38	CD
cord-017917-7aeh6quc	39	18	)	)	-RRB-
cord-017917-7aeh6quc	39	19	.	.	.
cord-017917-7aeh6quc	40	1	The	the	DT
cord-017917-7aeh6quc	40	2	induction	induction	NN
cord-017917-7aeh6quc	40	3	of	of	IN
cord-017917-7aeh6quc	40	4	MMP-7	MMP-7	NNP
cord-017917-7aeh6quc	40	5	mRNA	mRNA	NNP
cord-017917-7aeh6quc	40	6	expression	expression	NN
cord-017917-7aeh6quc	40	7	was	be	VBD
cord-017917-7aeh6quc	40	8	not	not	RB
cord-017917-7aeh6quc	40	9	detected	detect	VBN
cord-017917-7aeh6quc	40	10	but	but	CC
cord-017917-7aeh6quc	40	11	the	the	DT
cord-017917-7aeh6quc	40	12	presence	presence	NN
cord-017917-7aeh6quc	40	13	of	of	IN
cord-017917-7aeh6quc	40	14	MMP-7	MMP-7	NNP
cord-017917-7aeh6quc	40	15	protein	protein	NN
cord-017917-7aeh6quc	40	16	has	have	VBZ
cord-017917-7aeh6quc	40	17	also	also	RB
cord-017917-7aeh6quc	40	18	been	be	VBN
cord-017917-7aeh6quc	40	19	reported	report	VBN
cord-017917-7aeh6quc	40	20	during	during	IN
cord-017917-7aeh6quc	40	21	EAE	EAE	NNP
cord-017917-7aeh6quc	40	22	in	in	IN
cord-017917-7aeh6quc	40	23	rats	rat	NNS
cord-017917-7aeh6quc	40	24	(	(	-LRB-
cord-017917-7aeh6quc	40	25	10	10	CD
cord-017917-7aeh6quc	40	26	)	)	-RRB-
cord-017917-7aeh6quc	40	27	.	.	.
cord-017917-7aeh6quc	41	1	The	the	DT
cord-017917-7aeh6quc	41	2	consistent	consistent	JJ
cord-017917-7aeh6quc	41	3	association	association	NN
cord-017917-7aeh6quc	41	4	of	of	IN
cord-017917-7aeh6quc	41	5	MMP	MMP	NNP
cord-017917-7aeh6quc	41	6	and	and	CC
cord-017917-7aeh6quc	41	7	TIMP	TIMP	NNP
cord-017917-7aeh6quc	41	8	expression	expression	NN
cord-017917-7aeh6quc	41	9	with	with	IN
cord-017917-7aeh6quc	41	10	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	41	11	demyelinating	demyelinating	JJ
cord-017917-7aeh6quc	41	12	disease	disease	NN
cord-017917-7aeh6quc	41	13	suggests	suggest	VBZ
cord-017917-7aeh6quc	41	14	that	that	IN
cord-017917-7aeh6quc	41	15	MMPs	mmp	NNS
cord-017917-7aeh6quc	41	16	play	play	VB
cord-017917-7aeh6quc	41	17	either	either	CC
cord-017917-7aeh6quc	41	18	a	a	DT
cord-017917-7aeh6quc	41	19	direct	direct	JJ
cord-017917-7aeh6quc	41	20	or	or	CC
cord-017917-7aeh6quc	41	21	indirect	indirect	JJ
cord-017917-7aeh6quc	41	22	role	role	NN
cord-017917-7aeh6quc	41	23	in	in	IN
cord-017917-7aeh6quc	41	24	promoting	promote	VBG
cord-017917-7aeh6quc	41	25	CNS	CNS	NNP
cord-017917-7aeh6quc	41	26	pathology	pathology	NN
cord-017917-7aeh6quc	41	27	(	(	-LRB-
cord-017917-7aeh6quc	41	28	2,27,32	2,27,32	CD
cord-017917-7aeh6quc	41	29	)	)	-RRB-
cord-017917-7aeh6quc	41	30	.	.	.
cord-017917-7aeh6quc	42	1	However	however	RB
cord-017917-7aeh6quc	42	2	,	,	,
cord-017917-7aeh6quc	42	3	as	as	IN
cord-017917-7aeh6quc	42	4	discussed	discuss	VBN
cord-017917-7aeh6quc	42	5	below	below	RB
cord-017917-7aeh6quc	42	6	,	,	,
cord-017917-7aeh6quc	42	7	identifying	identify	VBG
cord-017917-7aeh6quc	42	8	specific	specific	JJ
cord-017917-7aeh6quc	42	9	MMPs	mmp	NNS
cord-017917-7aeh6quc	42	10	and	and	CC
cord-017917-7aeh6quc	42	11	their	-PRON-	PRP$
cord-017917-7aeh6quc	42	12	exact	exact	JJ
cord-017917-7aeh6quc	42	13	role	role	NN
cord-017917-7aeh6quc	42	14	in	in	IN
cord-017917-7aeh6quc	42	15	promoting	promote	VBG
cord-017917-7aeh6quc	42	16	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	42	17	/	/	SYM
cord-017917-7aeh6quc	42	18	demyelinating	demyelinating	NN
cord-017917-7aeh6quc	42	19	has	have	VBZ
cord-017917-7aeh6quc	42	20	proven	prove	VBN
cord-017917-7aeh6quc	42	21	to	to	TO
cord-017917-7aeh6quc	42	22	be	be	VB
cord-017917-7aeh6quc	42	23	difficult	difficult	JJ
cord-017917-7aeh6quc	42	24	.	.	.
cord-017917-7aeh6quc	43	1	In	in	IN
cord-017917-7aeh6quc	43	2	vitro	vitro	FW
cord-017917-7aeh6quc	43	3	infection	infection	NN
cord-017917-7aeh6quc	43	4	of	of	IN
cord-017917-7aeh6quc	43	5	human	human	JJ
cord-017917-7aeh6quc	43	6	astrocytic	astrocytic	JJ
cord-017917-7aeh6quc	43	7	and	and	CC
cord-017917-7aeh6quc	43	8	microglial	microglial	JJ
cord-017917-7aeh6quc	43	9	cell	cell	NN
cord-017917-7aeh6quc	43	10	lines	line	NNS
cord-017917-7aeh6quc	43	11	with	with	IN
cord-017917-7aeh6quc	43	12	human	human	JJ
cord-017917-7aeh6quc	43	13	coronavirus	coronavirus	NN
cord-017917-7aeh6quc	43	14	induced	induce	VBN
cord-017917-7aeh6quc	43	15	up	up	IN
cord-017917-7aeh6quc	43	16	-	-	HYPH
cord-017917-7aeh6quc	43	17	regulation	regulation	NN
cord-017917-7aeh6quc	43	18	of	of	IN
cord-017917-7aeh6quc	43	19	MMP-2	MMP-2	NNP
cord-017917-7aeh6quc	43	20	and	and	CC
cord-017917-7aeh6quc	43	21	-9	-9	NNP
cord-017917-7aeh6quc	43	22	protein	protein	NN
cord-017917-7aeh6quc	43	23	suggesting	suggest	VBG
cord-017917-7aeh6quc	43	24	that	that	IN
cord-017917-7aeh6quc	43	25	virus	virus	NN
cord-017917-7aeh6quc	43	26	infection	infection	NN
cord-017917-7aeh6quc	43	27	can	can	MD
cord-017917-7aeh6quc	43	28	up	up	RB
cord-017917-7aeh6quc	43	29	-	-	HYPH
cord-017917-7aeh6quc	43	30	regulate	regulate	VB
cord-017917-7aeh6quc	43	31	MMP	MMP	NNP
cord-017917-7aeh6quc	43	32	expression	expression	NN
cord-017917-7aeh6quc	43	33	within	within	IN
cord-017917-7aeh6quc	43	34	the	the	DT
cord-017917-7aeh6quc	43	35	CNS	CNS	NNP
cord-017917-7aeh6quc	43	36	(	(	-LRB-
cord-017917-7aeh6quc	43	37	15	15	CD
cord-017917-7aeh6quc	43	38	)	)	-RRB-
cord-017917-7aeh6quc	43	39	.	.	.
cord-017917-7aeh6quc	44	1	The	the	DT
cord-017917-7aeh6quc	44	2	mechanism	mechanism	NN
cord-017917-7aeh6quc	44	3	by	by	IN
cord-017917-7aeh6quc	44	4	which	which	WDT
cord-017917-7aeh6quc	44	5	MMPs	mmp	NNS
cord-017917-7aeh6quc	44	6	were	be	VBD
cord-017917-7aeh6quc	44	7	up	up	RB
cord-017917-7aeh6quc	44	8	-	-	HYPH
cord-017917-7aeh6quc	44	9	regulated	regulate	VBN
cord-017917-7aeh6quc	44	10	by	by	IN
cord-017917-7aeh6quc	44	11	infection	infection	NN
cord-017917-7aeh6quc	44	12	where	where	WRB
cord-017917-7aeh6quc	44	13	not	not	RB
cord-017917-7aeh6quc	44	14	known	know	VBN
cord-017917-7aeh6quc	44	15	,	,	,
cord-017917-7aeh6quc	44	16	however	however	RB
cord-017917-7aeh6quc	44	17	,	,	,
cord-017917-7aeh6quc	44	18	virus	virus	NN
cord-017917-7aeh6quc	44	19	infection	infection	NN
cord-017917-7aeh6quc	44	20	of	of	IN
cord-017917-7aeh6quc	44	21	the	the	DT
cord-017917-7aeh6quc	44	22	glial	glial	JJ
cord-017917-7aeh6quc	44	23	cell	cell	NN
cord-017917-7aeh6quc	44	24	lines	line	NNS
cord-017917-7aeh6quc	44	25	induced	induce	VBN
cord-017917-7aeh6quc	44	26	expression	expression	NN
cord-017917-7aeh6quc	44	27	of	of	IN
cord-017917-7aeh6quc	45	1	IL-6	IL-6	NNP
cord-017917-7aeh6quc	45	2	,	,	,
cord-017917-7aeh6quc	45	3	TNF	TNF	NNP
cord-017917-7aeh6quc	45	4	-	-	HYPH
cord-017917-7aeh6quc	45	5	c~	c~	NNP
cord-017917-7aeh6quc	45	6	and	and	CC
cord-017917-7aeh6quc	45	7	MCP-1	MCP-1	NNP
cord-017917-7aeh6quc	45	8	,	,	,
cord-017917-7aeh6quc	45	9	which	which	WDT
cord-017917-7aeh6quc	45	10	are	be	VBP
cord-017917-7aeh6quc	45	11	all	all	DT
cord-017917-7aeh6quc	45	12	inducers	inducer	NNS
cord-017917-7aeh6quc	45	13	of	of	IN
cord-017917-7aeh6quc	45	14	MMP	MMP	NNP
cord-017917-7aeh6quc	45	15	expression	expression	NN
cord-017917-7aeh6quc	45	16	(	(	-LRB-
cord-017917-7aeh6quc	45	17	15	15	CD
cord-017917-7aeh6quc	45	18	)	)	-RRB-
cord-017917-7aeh6quc	45	19	.	.	.
cord-017917-7aeh6quc	46	1	Transfer	transfer	NN
cord-017917-7aeh6quc	46	2	of	of	IN
cord-017917-7aeh6quc	46	3	non	non	JJ
cord-017917-7aeh6quc	46	4	-	-	JJ
cord-017917-7aeh6quc	46	5	infectious	infectious	JJ
cord-017917-7aeh6quc	46	6	supernatants	supernatant	NNS
cord-017917-7aeh6quc	46	7	from	from	IN
cord-017917-7aeh6quc	46	8	infected	infected	JJ
cord-017917-7aeh6quc	46	9	cultures	culture	NNS
cord-017917-7aeh6quc	46	10	to	to	IN
cord-017917-7aeh6quc	46	11	uninfected	uninfected	JJ
cord-017917-7aeh6quc	46	12	cells	cell	NNS
cord-017917-7aeh6quc	46	13	was	be	VBD
cord-017917-7aeh6quc	46	14	sufficient	sufficient	JJ
cord-017917-7aeh6quc	46	15	to	to	TO
cord-017917-7aeh6quc	46	16	induce	induce	VB
cord-017917-7aeh6quc	46	17	expression	expression	NN
cord-017917-7aeh6quc	46	18	of	of	IN
cord-017917-7aeh6quc	46	19	MMP-2	MMP-2	NNP
cord-017917-7aeh6quc	47	1	and	and	CC
cord-017917-7aeh6quc	47	2	-9	-9	NNP
cord-017917-7aeh6quc	47	3	.	.	.
cord-017917-7aeh6quc	48	1	MMP	MMP	NNP
cord-017917-7aeh6quc	48	2	expression	expression	NN
cord-017917-7aeh6quc	48	3	,	,	,
cord-017917-7aeh6quc	48	4	including	include	VBG
cord-017917-7aeh6quc	48	5	MMP-2	MMP-2	NNP
cord-017917-7aeh6quc	48	6	and	and	CC
cord-017917-7aeh6quc	48	7	-9	-9	NNP
cord-017917-7aeh6quc	48	8	,	,	,
cord-017917-7aeh6quc	48	9	is	be	VBZ
cord-017917-7aeh6quc	48	10	also	also	RB
cord-017917-7aeh6quc	48	11	elevated	elevate	VBN
cord-017917-7aeh6quc	48	12	in	in	IN
cord-017917-7aeh6quc	48	13	na'fve	na'fve	RB
cord-017917-7aeh6quc	48	14	transgenic	transgenic	JJ
cord-017917-7aeh6quc	48	15	mice	mouse	NNS
cord-017917-7aeh6quc	48	16	,	,	,
cord-017917-7aeh6quc	48	17	which	which	WDT
cord-017917-7aeh6quc	48	18	express	express	VBP
cord-017917-7aeh6quc	48	19	IL-6	IL-6	NNP
cord-017917-7aeh6quc	48	20	and	and	CC
cord-017917-7aeh6quc	48	21	TNF	TNF	NNP
cord-017917-7aeh6quc	48	22	-	-	HYPH
cord-017917-7aeh6quc	48	23	c~	c~	NNP
cord-017917-7aeh6quc	48	24	within	within	IN
cord-017917-7aeh6quc	48	25	the	the	DT
cord-017917-7aeh6quc	48	26	CNS	CNS	NNP
cord-017917-7aeh6quc	48	27	(	(	-LRB-
cord-017917-7aeh6quc	48	28	38	38	CD
cord-017917-7aeh6quc	48	29	)	)	-RRB-
cord-017917-7aeh6quc	48	30	.	.	.
cord-017917-7aeh6quc	49	1	These	these	DT
cord-017917-7aeh6quc	49	2	observations	observation	NNS
cord-017917-7aeh6quc	49	3	suggest	suggest	VBP
cord-017917-7aeh6quc	49	4	that	that	IN
cord-017917-7aeh6quc	49	5	viral	viral	JJ
cord-017917-7aeh6quc	49	6	infections	infection	NNS
cord-017917-7aeh6quc	49	7	induce	induce	VBP
cord-017917-7aeh6quc	49	8	expression	expression	NN
cord-017917-7aeh6quc	49	9	of	of	IN
cord-017917-7aeh6quc	49	10	chemokines	chemokine	NNS
cord-017917-7aeh6quc	49	11	/	/	SYM
cord-017917-7aeh6quc	49	12	cytokines	cytokine	NNS
cord-017917-7aeh6quc	49	13	,	,	,
cord-017917-7aeh6quc	49	14	which	which	WDT
cord-017917-7aeh6quc	49	15	in	in	IN
cord-017917-7aeh6quc	49	16	turn	turn	NN
cord-017917-7aeh6quc	49	17	induce	induce	VBP
cord-017917-7aeh6quc	49	18	MMP	MMP	NNP
cord-017917-7aeh6quc	49	19	expression	expression	NN
cord-017917-7aeh6quc	49	20	in	in	IN
cord-017917-7aeh6quc	49	21	neighboring	neighboring	NN
cord-017917-7aeh6quc	49	22	cells	cell	NNS
cord-017917-7aeh6quc	49	23	(	(	-LRB-
cord-017917-7aeh6quc	49	24	15	15	CD
cord-017917-7aeh6quc	49	25	,	,	,
cord-017917-7aeh6quc	49	26	38	38	CD
cord-017917-7aeh6quc	49	27	)	)	-RRB-
cord-017917-7aeh6quc	49	28	.	.	.
cord-017917-7aeh6quc	50	1	Recent	recent	JJ
cord-017917-7aeh6quc	50	2	examination	examination	NN
cord-017917-7aeh6quc	50	3	of	of	IN
cord-017917-7aeh6quc	50	4	MMP	MMP	NNP
cord-017917-7aeh6quc	50	5	gene	gene	NN
cord-017917-7aeh6quc	50	6	expression	expression	NN
cord-017917-7aeh6quc	50	7	within	within	IN
cord-017917-7aeh6quc	50	8	the	the	DT
cord-017917-7aeh6quc	50	9	brains	brain	NNS
cord-017917-7aeh6quc	50	10	of	of	IN
cord-017917-7aeh6quc	50	11	mice	mouse	NNS
cord-017917-7aeh6quc	50	12	infected	infect	VBN
cord-017917-7aeh6quc	50	13	with	with	IN
cord-017917-7aeh6quc	50	14	lethal	lethal	JJ
cord-017917-7aeh6quc	50	15	and	and	CC
cord-017917-7aeh6quc	50	16	attenuated	attenuated	JJ
cord-017917-7aeh6quc	50	17	MHV	MHV	NNP
cord-017917-7aeh6quc	50	18	-	-	HYPH
cord-017917-7aeh6quc	50	19	JHM	JHM	NNP
cord-017917-7aeh6quc	50	20	variants	variant	NNS
cord-017917-7aeh6quc	50	21	showed	show	VBD
cord-017917-7aeh6quc	50	22	that	that	IN
cord-017917-7aeh6quc	50	23	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	50	24	and	and	CC
cord-017917-7aeh6quc	50	25	-12	-12	:
cord-017917-7aeh6quc	50	26	mRNA	mRNA	NNP
cord-017917-7aeh6quc	50	27	were	be	VBD
cord-017917-7aeh6quc	50	28	rapidly	rapidly	RB
cord-017917-7aeh6quc	50	29	up	up	RB
cord-017917-7aeh6quc	50	30	regulated	regulate	VBN
cord-017917-7aeh6quc	50	31	during	during	IN
cord-017917-7aeh6quc	50	32	acute	acute	JJ
cord-017917-7aeh6quc	50	33	infections	infection	NNS
cord-017917-7aeh6quc	50	34	(	(	-LRB-
cord-017917-7aeh6quc	50	35	51	51	CD
cord-017917-7aeh6quc	50	36	,	,	,
cord-017917-7aeh6quc	50	37	53	53	CD
cord-017917-7aeh6quc	50	38	)	)	-RRB-
cord-017917-7aeh6quc	50	39	.	.	.
cord-017917-7aeh6quc	51	1	By	by	IN
cord-017917-7aeh6quc	51	2	contrast	contrast	NN
cord-017917-7aeh6quc	51	3	,	,	,
cord-017917-7aeh6quc	51	4	infection	infection	NN
cord-017917-7aeh6quc	51	5	did	do	VBD
cord-017917-7aeh6quc	51	6	not	not	RB
cord-017917-7aeh6quc	51	7	alter	alter	VB
cord-017917-7aeh6quc	51	8	transcription	transcription	NN
cord-017917-7aeh6quc	51	9	of	of	IN
cord-017917-7aeh6quc	51	10	the	the	DT
cord-017917-7aeh6quc	51	11	genes	gene	NNS
cord-017917-7aeh6quc	51	12	encoding	encode	VBG
cord-017917-7aeh6quc	51	13	MMP-2	MMP-2	NNP
cord-017917-7aeh6quc	51	14	,	,	,
cord-017917-7aeh6quc	51	15	-9	-9	ADD
cord-017917-7aeh6quc	51	16	,	,	,
cord-017917-7aeh6quc	51	17	-11	-11	''
cord-017917-7aeh6quc	51	18	or	or	CC
cord-017917-7aeh6quc	51	19	-14	-14	NNP
cord-017917-7aeh6quc	51	20	,	,	,
cord-017917-7aeh6quc	51	21	which	which	WDT
cord-017917-7aeh6quc	51	22	were	be	VBD
cord-017917-7aeh6quc	51	23	constitutively	constitutively	RB
cord-017917-7aeh6quc	51	24	expressed	express	VBN
cord-017917-7aeh6quc	51	25	in	in	IN
cord-017917-7aeh6quc	51	26	the	the	DT
cord-017917-7aeh6quc	51	27	CNS	CNS	NNP
cord-017917-7aeh6quc	51	28	of	of	IN
cord-017917-7aeh6quc	51	29	na'fve	na'fve	NN
cord-017917-7aeh6quc	52	1	BALB	BALB	NNP
cord-017917-7aeh6quc	52	2	/	/	SYM
cord-017917-7aeh6quc	52	3	c	c	NN
cord-017917-7aeh6quc	52	4	mice	mouse	NNS
cord-017917-7aeh6quc	52	5	(	(	-LRB-
cord-017917-7aeh6quc	52	6	51	51	CD
cord-017917-7aeh6quc	52	7	)	)	-RRB-
cord-017917-7aeh6quc	52	8	.	.	.
cord-017917-7aeh6quc	53	1	These	these	DT
cord-017917-7aeh6quc	53	2	data	datum	NNS
cord-017917-7aeh6quc	53	3	are	be	VBP
cord-017917-7aeh6quc	53	4	summarized	summarize	VBN
cord-017917-7aeh6quc	53	5	in	in	IN
cord-017917-7aeh6quc	53	6	Table	Table	NNP
cord-017917-7aeh6quc	53	7	1	1	CD
cord-017917-7aeh6quc	53	8	.	.	.
cord-017917-7aeh6quc	54	1	Kinetic	kinetic	JJ
cord-017917-7aeh6quc	54	2	analysis	analysis	NN
cord-017917-7aeh6quc	54	3	of	of	IN
cord-017917-7aeh6quc	54	4	MMP	MMP	NNP
cord-017917-7aeh6quc	54	5	expression	expression	NN
cord-017917-7aeh6quc	54	6	indicated	indicate	VBD
cord-017917-7aeh6quc	54	7	that	that	IN
cord-017917-7aeh6quc	54	8	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	54	9	and	and	CC
cord-017917-7aeh6quc	54	10	MMP-12	MMP-12	NNP
cord-017917-7aeh6quc	54	11	expression	expression	NN
cord-017917-7aeh6quc	54	12	peaked	peak	VBD
cord-017917-7aeh6quc	54	13	by	by	IN
cord-017917-7aeh6quc	54	14	6	6	CD
cord-017917-7aeh6quc	54	15	days	day	NNS
cord-017917-7aeh6quc	54	16	post	post	NN
cord-017917-7aeh6quc	54	17	infection	infection	NN
cord-017917-7aeh6quc	54	18	(	(	-LRB-
cord-017917-7aeh6quc	54	19	p.i	p.i	NNP
cord-017917-7aeh6quc	54	20	.	.	NNP
cord-017917-7aeh6quc	54	21	)	)	-RRB-
cord-017917-7aeh6quc	55	1	in	in	IN
cord-017917-7aeh6quc	55	2	accord	accord	NN
cord-017917-7aeh6quc	55	3	with	with	IN
cord-017917-7aeh6quc	55	4	viral	viral	JJ
cord-017917-7aeh6quc	55	5	load	load	NN
cord-017917-7aeh6quc	55	6	,	,	,
cord-017917-7aeh6quc	55	7	however	however	RB
cord-017917-7aeh6quc	55	8	,	,	,
cord-017917-7aeh6quc	55	9	expression	expression	NN
cord-017917-7aeh6quc	55	10	was	be	VBD
cord-017917-7aeh6quc	55	11	significantly	significantly	RB
cord-017917-7aeh6quc	55	12	higher	high	JJR
cord-017917-7aeh6quc	55	13	in	in	IN
cord-017917-7aeh6quc	55	14	lethally	lethally	RB
cord-017917-7aeh6quc	55	15	infected	infect	VBN
cord-017917-7aeh6quc	55	16	mice	mouse	NNS
cord-017917-7aeh6quc	55	17	(	(	-LRB-
cord-017917-7aeh6quc	55	18	51,52	51,52	CD
cord-017917-7aeh6quc	55	19	)	)	-RRB-
cord-017917-7aeh6quc	55	20	.	.	.
cord-017917-7aeh6quc	56	1	Comparisons	comparison	NNS
cord-017917-7aeh6quc	56	2	of	of	IN
cord-017917-7aeh6quc	56	3	MMP	MMP	NNP
cord-017917-7aeh6quc	56	4	/	/	SYM
cord-017917-7aeh6quc	56	5	TIMP	TIMP	NNP
cord-017917-7aeh6quc	56	6	expression	expression	NN
cord-017917-7aeh6quc	56	7	in	in	IN
cord-017917-7aeh6quc	56	8	infected	infected	JJ
cord-017917-7aeh6quc	56	9	irradiated	irradiate	VBN
cord-017917-7aeh6quc	56	10	and	and	CC
cord-017917-7aeh6quc	56	11	control	control	NN
cord-017917-7aeh6quc	56	12	mice	mouse	NNS
cord-017917-7aeh6quc	56	13	revealed	reveal	VBD
cord-017917-7aeh6quc	56	14	relatively	relatively	RB
cord-017917-7aeh6quc	56	15	little	little	JJ
cord-017917-7aeh6quc	56	16	loss	loss	NN
cord-017917-7aeh6quc	56	17	in	in	IN
cord-017917-7aeh6quc	56	18	MMP	MMP	NNP
cord-017917-7aeh6quc	56	19	or	or	CC
cord-017917-7aeh6quc	56	20	TIMP	TIMP	NNP
cord-017917-7aeh6quc	56	21	expression	expression	NN
cord-017917-7aeh6quc	56	22	in	in	IN
cord-017917-7aeh6quc	56	23	immunosuppressed	immunosuppressed	JJ
cord-017917-7aeh6quc	56	24	mice	mouse	NNS
cord-017917-7aeh6quc	56	25	(	(	-LRB-
cord-017917-7aeh6quc	56	26	51	51	CD
cord-017917-7aeh6quc	56	27	)	)	-RRB-
cord-017917-7aeh6quc	56	28	.	.	.
cord-017917-7aeh6quc	57	1	These	these	DT
cord-017917-7aeh6quc	57	2	results	result	NNS
cord-017917-7aeh6quc	57	3	indicated	indicate	VBD
cord-017917-7aeh6quc	57	4	that	that	IN
cord-017917-7aeh6quc	57	5	CNS	CNS	NNP
cord-017917-7aeh6quc	57	6	resident	resident	NN
cord-017917-7aeh6quc	57	7	cells	cell	NNS
cord-017917-7aeh6quc	57	8	were	be	VBD
cord-017917-7aeh6quc	57	9	responsible	responsible	JJ
cord-017917-7aeh6quc	57	10	for	for	IN
cord-017917-7aeh6quc	57	11	the	the	DT
cord-017917-7aeh6quc	57	12	majority	majority	NN
cord-017917-7aeh6quc	57	13	of	of	IN
cord-017917-7aeh6quc	57	14	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	57	15	,	,	,
cord-017917-7aeh6quc	57	16	and	and	CC
cord-017917-7aeh6quc	57	17	-12	-12	:
cord-017917-7aeh6quc	57	18	gene	gene	NN
cord-017917-7aeh6quc	57	19	expression	expression	NN
cord-017917-7aeh6quc	57	20	detected	detect	VBN
cord-017917-7aeh6quc	57	21	within	within	IN
cord-017917-7aeh6quc	57	22	the	the	DT
cord-017917-7aeh6quc	57	23	brain	brain	NN
cord-017917-7aeh6quc	57	24	and	and	CC
cord-017917-7aeh6quc	57	25	that	that	IN
cord-017917-7aeh6quc	57	26	this	this	DT
cord-017917-7aeh6quc	57	27	gene	gene	NN
cord-017917-7aeh6quc	57	28	induction	induction	NN
cord-017917-7aeh6quc	57	29	was	be	VBD
cord-017917-7aeh6quc	57	30	relatively	relatively	RB
cord-017917-7aeh6quc	57	31	independent	independent	JJ
cord-017917-7aeh6quc	57	32	of	of	IN
cord-017917-7aeh6quc	57	33	the	the	DT
cord-017917-7aeh6quc	57	34	presence	presence	NN
cord-017917-7aeh6quc	57	35	of	of	IN
cord-017917-7aeh6quc	57	36	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	57	37	cell	cell	NN
cord-017917-7aeh6quc	57	38	infiltration	infiltration	NN
cord-017917-7aeh6quc	57	39	.	.	.
cord-017917-7aeh6quc	58	1	Expression	expression	NN
cord-017917-7aeh6quc	58	2	of	of	IN
cord-017917-7aeh6quc	58	3	MMPs	mmp	NNS
cord-017917-7aeh6quc	58	4	constitutively	constitutively	RB
cord-017917-7aeh6quc	58	5	expressed	express	VBN
cord-017917-7aeh6quc	58	6	in	in	IN
cord-017917-7aeh6quc	58	7	naive	naive	JJ
cord-017917-7aeh6quc	58	8	mice	mouse	NNS
cord-017917-7aeh6quc	58	9	(	(	-LRB-
cord-017917-7aeh6quc	58	10	MMP-2	MMP-2	NNP
cord-017917-7aeh6quc	58	11	,	,	,
cord-017917-7aeh6quc	58	12	-9	-9	ADD
cord-017917-7aeh6quc	58	13	,	,	,
cord-017917-7aeh6quc	58	14	-11	-11	NNP
cord-017917-7aeh6quc	58	15	,	,	,
cord-017917-7aeh6quc	58	16	-14	-14	NN
cord-017917-7aeh6quc	58	17	)	)	-RRB-
cord-017917-7aeh6quc	58	18	were	be	VBD
cord-017917-7aeh6quc	58	19	unaffected	unaffected	JJ
cord-017917-7aeh6quc	58	20	by	by	IN
cord-017917-7aeh6quc	58	21	immunosuppression	immunosuppression	NN
cord-017917-7aeh6quc	58	22	.	.	.
cord-017917-7aeh6quc	59	1	TIMP-2	TIMP-2	NNP
cord-017917-7aeh6quc	59	2	TIMP-3	TIMP-3	NNP
cord-017917-7aeh6quc	59	3	RNA	RNA	NNP
cord-017917-7aeh6quc	59	4	was	be	VBD
cord-017917-7aeh6quc	59	5	prepared	prepare	VBN
cord-017917-7aeh6quc	59	6	from	from	IN
cord-017917-7aeh6quc	59	7	brains	brain	NNS
cord-017917-7aeh6quc	59	8	of	of	IN
cord-017917-7aeh6quc	59	9	MHV	MHV	NNP
cord-017917-7aeh6quc	59	10	-	-	HYPH
cord-017917-7aeh6quc	59	11	JHM	JHM	NNP
cord-017917-7aeh6quc	59	12	infected	infect	VBD
cord-017917-7aeh6quc	59	13	mice	mouse	NNS
cord-017917-7aeh6quc	59	14	.	.	.
cord-017917-7aeh6quc	60	1	Relative	relative	JJ
cord-017917-7aeh6quc	60	2	gene	gene	NN
cord-017917-7aeh6quc	60	3	expression	expression	NN
cord-017917-7aeh6quc	60	4	was	be	VBD
cord-017917-7aeh6quc	60	5	determined	determine	VBN
cord-017917-7aeh6quc	60	6	by	by	IN
cord-017917-7aeh6quc	60	7	RNase	rnase	NN
cord-017917-7aeh6quc	60	8	protection	protection	NN
cord-017917-7aeh6quc	60	9	assay	assay	NN
cord-017917-7aeh6quc	60	10	.	.	.
cord-017917-7aeh6quc	61	1	b	b	LS
cord-017917-7aeh6quc	61	2	Analysis	Analysis	NNP
cord-017917-7aeh6quc	61	3	of	of	IN
cord-017917-7aeh6quc	61	4	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	61	5	expression	expression	NN
cord-017917-7aeh6quc	61	6	by	by	IN
cord-017917-7aeh6quc	61	7	RNase	rnase	NN
cord-017917-7aeh6quc	61	8	protection	protection	NN
cord-017917-7aeh6quc	61	9	assay	assay	NN
cord-017917-7aeh6quc	61	10	did	do	VBD
cord-017917-7aeh6quc	61	11	not	not	RB
cord-017917-7aeh6quc	61	12	reveal	reveal	VB
cord-017917-7aeh6quc	61	13	an	an	DT
cord-017917-7aeh6quc	61	14	increase	increase	NN
cord-017917-7aeh6quc	61	15	in	in	IN
cord-017917-7aeh6quc	61	16	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	61	17	expression	expression	NN
cord-017917-7aeh6quc	61	18	in	in	IN
cord-017917-7aeh6quc	61	19	RNA	RNA	NNP
cord-017917-7aeh6quc	61	20	prepared	prepare	VBN
cord-017917-7aeh6quc	61	21	from	from	IN
cord-017917-7aeh6quc	61	22	total	total	JJ
cord-017917-7aeh6quc	61	23	brain	brain	NN
cord-017917-7aeh6quc	61	24	.	.	.
cord-017917-7aeh6quc	62	1	However	however	RB
cord-017917-7aeh6quc	62	2	,	,	,
cord-017917-7aeh6quc	62	3	analysis	analysis	NN
cord-017917-7aeh6quc	62	4	of	of	IN
cord-017917-7aeh6quc	62	5	MMP	MMP	NNP
cord-017917-7aeh6quc	62	6	expression	expression	NN
cord-017917-7aeh6quc	62	7	from	from	IN
cord-017917-7aeh6quc	62	8	CD45	CD45	NNP
cord-017917-7aeh6quc	62	9	hi	hi	CD
cord-017917-7aeh6quc	62	10	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	62	11	cells	cell	NNS
cord-017917-7aeh6quc	62	12	isolated	isolate	VBN
cord-017917-7aeh6quc	62	13	from	from	IN
cord-017917-7aeh6quc	62	14	the	the	DT
cord-017917-7aeh6quc	62	15	CNS	CNS	NNP
cord-017917-7aeh6quc	62	16	indicated	indicate	VBD
cord-017917-7aeh6quc	62	17	that	that	IN
cord-017917-7aeh6quc	62	18	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	62	19	expression	expression	NN
cord-017917-7aeh6quc	62	20	was	be	VBD
cord-017917-7aeh6quc	62	21	increased	increase	VBN
cord-017917-7aeh6quc	62	22	during	during	IN
cord-017917-7aeh6quc	62	23	MHV	MHV	NNP
cord-017917-7aeh6quc	62	24	infection	infection	NN
cord-017917-7aeh6quc	62	25	.	.	.
cord-017917-7aeh6quc	63	1	Four	four	CD
cord-017917-7aeh6quc	63	2	TIMPs	timp	NNS
cord-017917-7aeh6quc	63	3	have	have	VBP
cord-017917-7aeh6quc	63	4	been	be	VBN
cord-017917-7aeh6quc	63	5	characterized	characterize	VBN
cord-017917-7aeh6quc	63	6	and	and	CC
cord-017917-7aeh6quc	63	7	all	all	DT
cord-017917-7aeh6quc	63	8	are	be	VBP
cord-017917-7aeh6quc	63	9	capable	capable	JJ
cord-017917-7aeh6quc	63	10	of	of	IN
cord-017917-7aeh6quc	63	11	inhibiting	inhibit	VBG
cord-017917-7aeh6quc	63	12	a	a	DT
cord-017917-7aeh6quc	63	13	range	range	NN
cord-017917-7aeh6quc	63	14	of	of	IN
cord-017917-7aeh6quc	63	15	MMPs	mmp	NNS
cord-017917-7aeh6quc	63	16	(	(	-LRB-
cord-017917-7aeh6quc	63	17	7	7	CD
cord-017917-7aeh6quc	63	18	,	,	,
cord-017917-7aeh6quc	63	19	23	23	CD
cord-017917-7aeh6quc	63	20	)	)	-RRB-
cord-017917-7aeh6quc	63	21	.	.	.
cord-017917-7aeh6quc	64	1	Basal	basal	JJ
cord-017917-7aeh6quc	64	2	expression	expression	NN
cord-017917-7aeh6quc	64	3	of	of	IN
cord-017917-7aeh6quc	64	4	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	64	5	is	be	VBZ
cord-017917-7aeh6quc	64	6	low	low	JJ
cord-017917-7aeh6quc	64	7	but	but	CC
cord-017917-7aeh6quc	64	8	readily	readily	RB
cord-017917-7aeh6quc	64	9	induced	induce	VBN
cord-017917-7aeh6quc	64	10	in	in	IN
cord-017917-7aeh6quc	64	11	response	response	NN
cord-017917-7aeh6quc	64	12	to	to	IN
cord-017917-7aeh6quc	64	13	a	a	DT
cord-017917-7aeh6quc	64	14	multitude	multitude	NN
cord-017917-7aeh6quc	64	15	of	of	IN
cord-017917-7aeh6quc	64	16	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	64	17	signals	signal	NNS
cord-017917-7aeh6quc	64	18	(	(	-LRB-
cord-017917-7aeh6quc	64	19	5,7	5,7	CD
cord-017917-7aeh6quc	64	20	)	)	-RRB-
cord-017917-7aeh6quc	64	21	.	.	.
cord-017917-7aeh6quc	65	1	By	by	IN
cord-017917-7aeh6quc	65	2	comparison	comparison	NN
cord-017917-7aeh6quc	65	3	,	,	,
cord-017917-7aeh6quc	65	4	TIMP-2	TIMP-2	NNP
cord-017917-7aeh6quc	65	5	,	,	,
cord-017917-7aeh6quc	65	6	-3	-3	NNP
cord-017917-7aeh6quc	65	7	and	and	CC
cord-017917-7aeh6quc	65	8	-4	-4	NNP
cord-017917-7aeh6quc	65	9	are	be	VBP
cord-017917-7aeh6quc	65	10	expressed	express	VBN
cord-017917-7aeh6quc	65	11	constitutively	constitutively	RB
cord-017917-7aeh6quc	65	12	and	and	CC
cord-017917-7aeh6quc	65	13	alterations	alteration	NNS
cord-017917-7aeh6quc	65	14	in	in	IN
cord-017917-7aeh6quc	65	15	their	-PRON-	PRP$
cord-017917-7aeh6quc	65	16	expression	expression	NN
cord-017917-7aeh6quc	65	17	are	be	VBP
cord-017917-7aeh6quc	65	18	less	less	RBR
cord-017917-7aeh6quc	65	19	frequently	frequently	RB
cord-017917-7aeh6quc	65	20	associated	associate	VBN
cord-017917-7aeh6quc	65	21	with	with	IN
cord-017917-7aeh6quc	65	22	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	65	23	responses	response	NNS
cord-017917-7aeh6quc	65	24	(	(	-LRB-
cord-017917-7aeh6quc	65	25	26,31,38	26,31,38	CD
cord-017917-7aeh6quc	65	26	)	)	-RRB-
cord-017917-7aeh6quc	65	27	.	.	.
cord-017917-7aeh6quc	66	1	Examination	examination	NN
cord-017917-7aeh6quc	66	2	of	of	IN
cord-017917-7aeh6quc	66	3	naive	naive	JJ
cord-017917-7aeh6quc	66	4	and	and	CC
cord-017917-7aeh6quc	66	5	MHV	MHV	NNP
cord-017917-7aeh6quc	66	6	-	-	HYPH
cord-017917-7aeh6quc	66	7	JHM	JHM	NNP
cord-017917-7aeh6quc	66	8	infected	infect	VBN
cord-017917-7aeh6quc	66	9	brains	brain	NNS
cord-017917-7aeh6quc	66	10	revealed	reveal	VBD
cord-017917-7aeh6quc	66	11	that	that	IN
cord-017917-7aeh6quc	66	12	TIMP-2	TIMP-2	NNP
cord-017917-7aeh6quc	66	13	and	and	CC
cord-017917-7aeh6quc	66	14	-3	-3	NNP
cord-017917-7aeh6quc	66	15	were	be	VBD
cord-017917-7aeh6quc	66	16	unaffected	unaffected	JJ
cord-017917-7aeh6quc	66	17	by	by	IN
cord-017917-7aeh6quc	66	18	the	the	DT
cord-017917-7aeh6quc	66	19	infection	infection	NN
cord-017917-7aeh6quc	66	20	(	(	-LRB-
cord-017917-7aeh6quc	66	21	51	51	CD
cord-017917-7aeh6quc	66	22	)	)	-RRB-
cord-017917-7aeh6quc	66	23	(	(	-LRB-
cord-017917-7aeh6quc	66	24	Table	table	NN
cord-017917-7aeh6quc	66	25	1	1	CD
cord-017917-7aeh6quc	66	26	)	)	-RRB-
cord-017917-7aeh6quc	66	27	.	.	.
cord-017917-7aeh6quc	67	1	By	by	IN
cord-017917-7aeh6quc	67	2	contrast	contrast	NN
cord-017917-7aeh6quc	67	3	,	,	,
cord-017917-7aeh6quc	67	4	MHV	MHV	NNP
cord-017917-7aeh6quc	67	5	infection	infection	NN
cord-017917-7aeh6quc	67	6	induced	induce	VBD
cord-017917-7aeh6quc	67	7	rapid	rapid	JJ
cord-017917-7aeh6quc	67	8	expression	expression	NN
cord-017917-7aeh6quc	67	9	of	of	IN
cord-017917-7aeh6quc	67	10	T1MP-1	T1MP-1	NNP
cord-017917-7aeh6quc	67	11	(	(	-LRB-
cord-017917-7aeh6quc	67	12	51	51	CD
cord-017917-7aeh6quc	67	13	)	)	-RRB-
cord-017917-7aeh6quc	68	1	(	(	-LRB-
cord-017917-7aeh6quc	68	2	Table	table	NN
cord-017917-7aeh6quc	68	3	 	 	_SP
cord-017917-7aeh6quc	68	4	1	1	CD
cord-017917-7aeh6quc	68	5	)	)	-RRB-
cord-017917-7aeh6quc	68	6	.	.	.
cord-017917-7aeh6quc	69	1	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	69	2	expression	expression	NN
cord-017917-7aeh6quc	69	3	peaked	peak	VBD
cord-017917-7aeh6quc	69	4	by	by	IN
cord-017917-7aeh6quc	69	5	6	6	CD
cord-017917-7aeh6quc	69	6	p.i	p.i	NNP
cord-017917-7aeh6quc	69	7	.	.	NNP
cord-017917-7aeh6quc	69	8	in	in	IN
cord-017917-7aeh6quc	69	9	conjunction	conjunction	NN
cord-017917-7aeh6quc	69	10	with	with	IN
cord-017917-7aeh6quc	69	11	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	69	12	and	and	CC
cord-017917-7aeh6quc	69	13	-12	-12	CD
cord-017917-7aeh6quc	69	14	expression	expression	NN
cord-017917-7aeh6quc	69	15	(	(	-LRB-
cord-017917-7aeh6quc	69	16	51,52	51,52	CD
cord-017917-7aeh6quc	69	17	)	)	-RRB-
cord-017917-7aeh6quc	69	18	.	.	.
cord-017917-7aeh6quc	70	1	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	70	2	expression	expression	NN
cord-017917-7aeh6quc	70	3	was	be	VBD
cord-017917-7aeh6quc	70	4	higher	high	JJR
cord-017917-7aeh6quc	70	5	in	in	IN
cord-017917-7aeh6quc	70	6	lethally	lethally	RB
cord-017917-7aeh6quc	70	7	infected	infected	JJ
cord-017917-7aeh6quc	70	8	mice	mouse	NNS
cord-017917-7aeh6quc	70	9	compared	compare	VBN
cord-017917-7aeh6quc	70	10	to	to	IN
cord-017917-7aeh6quc	70	11	sublethally	sublethally	RB
cord-017917-7aeh6quc	70	12	infected	infected	JJ
cord-017917-7aeh6quc	70	13	mice	mouse	NNS
cord-017917-7aeh6quc	70	14	suggesting	suggest	VBG
cord-017917-7aeh6quc	70	15	that	that	IN
cord-017917-7aeh6quc	70	16	expression	expression	NN
cord-017917-7aeh6quc	70	17	is	be	VBZ
cord-017917-7aeh6quc	70	18	dependent	dependent	JJ
cord-017917-7aeh6quc	70	19	on	on	IN
cord-017917-7aeh6quc	70	20	viral	viral	JJ
cord-017917-7aeh6quc	70	21	load	load	NN
cord-017917-7aeh6quc	70	22	and/or	and/or	CC
cord-017917-7aeh6quc	70	23	virulence	virulence	NN
cord-017917-7aeh6quc	70	24	.	.	.
cord-017917-7aeh6quc	71	1	T1MP-1	t1mp-1	NN
cord-017917-7aeh6quc	71	2	expression	expression	NN
cord-017917-7aeh6quc	71	3	has	have	VBZ
cord-017917-7aeh6quc	71	4	been	be	VBN
cord-017917-7aeh6quc	71	5	reported	report	VBN
cord-017917-7aeh6quc	71	6	to	to	TO
cord-017917-7aeh6quc	71	7	be	be	VB
cord-017917-7aeh6quc	71	8	associated	associate	VBN
cord-017917-7aeh6quc	71	9	with	with	IN
cord-017917-7aeh6quc	71	10	both	both	DT
cord-017917-7aeh6quc	71	11	tissue	tissue	NN
cord-017917-7aeh6quc	71	12	resident	resident	NN
cord-017917-7aeh6quc	71	13	cells	cell	NNS
cord-017917-7aeh6quc	71	14	as	as	RB
cord-017917-7aeh6quc	71	15	well	well	RB
cord-017917-7aeh6quc	71	16	as	as	IN
cord-017917-7aeh6quc	71	17	most	most	JJS
cord-017917-7aeh6quc	71	18	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	71	19	cells	cell	NNS
cord-017917-7aeh6quc	71	20	(	(	-LRB-
cord-017917-7aeh6quc	71	21	7	7	CD
cord-017917-7aeh6quc	71	22	)	)	-RRB-
cord-017917-7aeh6quc	71	23	.	.	.
cord-017917-7aeh6quc	72	1	Expression	expression	NN
cord-017917-7aeh6quc	72	2	levels	level	NNS
cord-017917-7aeh6quc	72	3	of	of	IN
cord-017917-7aeh6quc	72	4	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	72	5	were	be	VBD
cord-017917-7aeh6quc	72	6	higher	high	JJR
cord-017917-7aeh6quc	72	7	in	in	IN
cord-017917-7aeh6quc	72	8	irradiated	irradiate	VBN
cord-017917-7aeh6quc	72	9	,	,	,
cord-017917-7aeh6quc	72	10	immuncompromised	immuncompromised	JJ
cord-017917-7aeh6quc	72	11	mice	mouse	NNS
cord-017917-7aeh6quc	72	12	compared	compare	VBN
cord-017917-7aeh6quc	72	13	to	to	TO
cord-017917-7aeh6quc	72	14	control	control	NN
cord-017917-7aeh6quc	72	15	animals	animal	NNS
cord-017917-7aeh6quc	72	16	,	,	,
cord-017917-7aeh6quc	72	17	indicating	indicate	VBG
cord-017917-7aeh6quc	72	18	that	that	IN
cord-017917-7aeh6quc	72	19	most	most	JJS
cord-017917-7aeh6quc	72	20	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	72	21	is	be	VBZ
cord-017917-7aeh6quc	72	22	produced	produce	VBN
cord-017917-7aeh6quc	72	23	by	by	IN
cord-017917-7aeh6quc	72	24	CNS	CNS	NNP
cord-017917-7aeh6quc	72	25	resident	resident	NN
cord-017917-7aeh6quc	72	26	cells	cell	NNS
cord-017917-7aeh6quc	72	27	(	(	-LRB-
cord-017917-7aeh6quc	72	28	51	51	CD
cord-017917-7aeh6quc	72	29	)	)	-RRB-
cord-017917-7aeh6quc	72	30	.	.	.
cord-017917-7aeh6quc	73	1	Analysis	analysis	NN
cord-017917-7aeh6quc	73	2	of	of	IN
cord-017917-7aeh6quc	73	3	whole	whole	JJ
cord-017917-7aeh6quc	73	4	brain	brain	NN
cord-017917-7aeh6quc	73	5	samples	sample	NNS
cord-017917-7aeh6quc	73	6	for	for	IN
cord-017917-7aeh6quc	73	7	MMP	MMP	NNP
cord-017917-7aeh6quc	73	8	RNA	RNA	NNP
cord-017917-7aeh6quc	73	9	and	and	CC
cord-017917-7aeh6quc	73	10	protein	protein	NN
cord-017917-7aeh6quc	73	11	failed	fail	VBD
cord-017917-7aeh6quc	73	12	to	to	TO
cord-017917-7aeh6quc	73	13	detect	detect	VB
cord-017917-7aeh6quc	73	14	induction	induction	NN
cord-017917-7aeh6quc	73	15	of	of	IN
cord-017917-7aeh6quc	73	16	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	73	17	expression	expression	NN
cord-017917-7aeh6quc	73	18	during	during	IN
cord-017917-7aeh6quc	73	19	MHV	MHV	NNP
cord-017917-7aeh6quc	73	20	infection	infection	NN
cord-017917-7aeh6quc	73	21	(	(	-LRB-
cord-017917-7aeh6quc	73	22	51	51	CD
cord-017917-7aeh6quc	73	23	)	)	-RRB-
cord-017917-7aeh6quc	73	24	,	,	,
cord-017917-7aeh6quc	73	25	which	which	WDT
cord-017917-7aeh6quc	73	26	was	be	VBD
cord-017917-7aeh6quc	73	27	in	in	IN
cord-017917-7aeh6quc	73	28	sharp	sharp	JJ
cord-017917-7aeh6quc	73	29	contrast	contrast	NN
cord-017917-7aeh6quc	73	30	to	to	IN
cord-017917-7aeh6quc	73	31	its	-PRON-	PRP$
cord-017917-7aeh6quc	73	32	prominence	prominence	NN
cord-017917-7aeh6quc	73	33	in	in	IN
cord-017917-7aeh6quc	73	34	MS	MS	NNP
cord-017917-7aeh6quc	73	35	.	.	.
cord-017917-7aeh6quc	74	1	However	however	RB
cord-017917-7aeh6quc	74	2	,	,	,
cord-017917-7aeh6quc	74	3	subsequent	subsequent	JJ
cord-017917-7aeh6quc	74	4	analysis	analysis	NN
cord-017917-7aeh6quc	74	5	of	of	IN
cord-017917-7aeh6quc	74	6	individual	individual	JJ
cord-017917-7aeh6quc	74	7	cell	cell	NN
cord-017917-7aeh6quc	74	8	populations	population	NNS
cord-017917-7aeh6quc	74	9	sorted	sort	VBN
cord-017917-7aeh6quc	74	10	from	from	IN
cord-017917-7aeh6quc	74	11	infected	infected	JJ
cord-017917-7aeh6quc	74	12	brains	brain	NNS
cord-017917-7aeh6quc	74	13	indicated	indicate	VBD
cord-017917-7aeh6quc	74	14	that	that	IN
cord-017917-7aeh6quc	74	15	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	74	16	gene	gene	NN
cord-017917-7aeh6quc	74	17	expression	expression	NN
cord-017917-7aeh6quc	74	18	is	be	VBZ
cord-017917-7aeh6quc	74	19	up	up	RB
cord-017917-7aeh6quc	74	20	regulated	regulate	VBN
cord-017917-7aeh6quc	74	21	several	several	JJ
cord-017917-7aeh6quc	74	22	fold	fold	NN
cord-017917-7aeh6quc	74	23	among	among	IN
cord-017917-7aeh6quc	74	24	infiltrating	infiltrate	VBG
cord-017917-7aeh6quc	74	25	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	74	26	cells	cell	NNS
cord-017917-7aeh6quc	74	27	(	(	-LRB-
cord-017917-7aeh6quc	74	28	Zhou	Zhou	NNP
cord-017917-7aeh6quc	74	29	,	,	,
cord-017917-7aeh6quc	74	30	unpublished	unpublished	JJ
cord-017917-7aeh6quc	74	31	data	datum	NNS
cord-017917-7aeh6quc	74	32	)	)	-RRB-
cord-017917-7aeh6quc	75	1	(	(	-LRB-
cord-017917-7aeh6quc	75	2	Table	table	NN
cord-017917-7aeh6quc	75	3	1	1	CD
cord-017917-7aeh6quc	75	4	)	)	-RRB-
cord-017917-7aeh6quc	75	5	.	.	.
cord-017917-7aeh6quc	76	1	Similarly	similarly	RB
cord-017917-7aeh6quc	76	2	,	,	,
cord-017917-7aeh6quc	76	3	a	a	DT
cord-017917-7aeh6quc	76	4	strong	strong	JJ
cord-017917-7aeh6quc	76	5	induction	induction	NN
cord-017917-7aeh6quc	76	6	in	in	IN
cord-017917-7aeh6quc	76	7	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	76	8	expression	expression	NN
cord-017917-7aeh6quc	76	9	within	within	IN
cord-017917-7aeh6quc	76	10	the	the	DT
cord-017917-7aeh6quc	76	11	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	76	12	cell	cell	NN
cord-017917-7aeh6quc	76	13	populations	population	NNS
cord-017917-7aeh6quc	76	14	(	(	-LRB-
cord-017917-7aeh6quc	76	15	Zhou	Zhou	NNP
cord-017917-7aeh6quc	76	16	,	,	,
cord-017917-7aeh6quc	76	17	unpublished	unpublished	JJ
cord-017917-7aeh6quc	76	18	data	datum	NNS
cord-017917-7aeh6quc	76	19	)	)	-RRB-
cord-017917-7aeh6quc	76	20	suggests	suggest	VBZ
cord-017917-7aeh6quc	76	21	that	that	IN
cord-017917-7aeh6quc	76	22	T	T	NNP
cord-017917-7aeh6quc	76	23	cells	cell	NNS
cord-017917-7aeh6quc	76	24	are	be	VBP
cord-017917-7aeh6quc	76	25	,	,	,
cord-017917-7aeh6quc	76	26	at	at	IN
cord-017917-7aeh6quc	76	27	least	least	JJS
cord-017917-7aeh6quc	76	28	in	in	IN
cord-017917-7aeh6quc	76	29	part	part	NN
cord-017917-7aeh6quc	76	30	,	,	,
cord-017917-7aeh6quc	76	31	a	a	DT
cord-017917-7aeh6quc	76	32	source	source	NN
cord-017917-7aeh6quc	76	33	of	of	IN
cord-017917-7aeh6quc	76	34	both	both	CC
cord-017917-7aeh6quc	76	35	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	76	36	and	and	CC
cord-017917-7aeh6quc	76	37	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	76	38	as	as	IN
cord-017917-7aeh6quc	76	39	both	both	DT
cord-017917-7aeh6quc	76	40	of	of	IN
cord-017917-7aeh6quc	76	41	these	these	DT
cord-017917-7aeh6quc	76	42	genes	gene	NNS
cord-017917-7aeh6quc	76	43	are	be	VBP
cord-017917-7aeh6quc	76	44	co	co	VBN
cord-017917-7aeh6quc	76	45	-	-	VBN
cord-017917-7aeh6quc	76	46	expressed	express	VBN
cord-017917-7aeh6quc	76	47	by	by	IN
cord-017917-7aeh6quc	76	48	T	T	NNP
cord-017917-7aeh6quc	76	49	cells	cell	NNS
cord-017917-7aeh6quc	76	50	(	(	-LRB-
cord-017917-7aeh6quc	76	51	35	35	CD
cord-017917-7aeh6quc	76	52	)	)	-RRB-
cord-017917-7aeh6quc	76	53	.	.	.
cord-017917-7aeh6quc	77	1	Furthermore	furthermore	RB
cord-017917-7aeh6quc	77	2	,	,	,
cord-017917-7aeh6quc	77	3	analysis	analysis	NN
cord-017917-7aeh6quc	77	4	of	of	IN
cord-017917-7aeh6quc	77	5	cell	cell	NN
cord-017917-7aeh6quc	77	6	extracts	extract	NNS
cord-017917-7aeh6quc	77	7	prepared	prepare	VBN
cord-017917-7aeh6quc	77	8	from	from	IN
cord-017917-7aeh6quc	77	9	infiltrating	infiltrate	VBG
cord-017917-7aeh6quc	77	10	cells	cell	NNS
cord-017917-7aeh6quc	77	11	revealed	reveal	VBD
cord-017917-7aeh6quc	77	12	that	that	IN
cord-017917-7aeh6quc	77	13	MHV	MHV	NNP
cord-017917-7aeh6quc	77	14	infection	infection	NN
cord-017917-7aeh6quc	77	15	also	also	RB
cord-017917-7aeh6quc	77	16	induced	induce	VBD
cord-017917-7aeh6quc	77	17	a	a	DT
cord-017917-7aeh6quc	77	18	sharp	sharp	JJ
cord-017917-7aeh6quc	77	19	rise	rise	NN
cord-017917-7aeh6quc	77	20	in	in	IN
cord-017917-7aeh6quc	77	21	the	the	DT
cord-017917-7aeh6quc	77	22	level	level	NN
cord-017917-7aeh6quc	77	23	of	of	IN
cord-017917-7aeh6quc	77	24	intracellular	intracellular	JJ
cord-017917-7aeh6quc	77	25	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	77	26	protein	protein	NN
cord-017917-7aeh6quc	77	27	(	(	-LRB-
cord-017917-7aeh6quc	77	28	51	51	CD
cord-017917-7aeh6quc	77	29	,	,	,
cord-017917-7aeh6quc	77	30	53	53	CD
cord-017917-7aeh6quc	77	31	)	)	-RRB-
cord-017917-7aeh6quc	77	32	.	.	.
cord-017917-7aeh6quc	78	1	The	the	DT
cord-017917-7aeh6quc	78	2	increase	increase	NN
cord-017917-7aeh6quc	78	3	in	in	IN
cord-017917-7aeh6quc	78	4	intracellular	intracellular	JJ
cord-017917-7aeh6quc	78	5	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	78	6	protein	protein	NN
cord-017917-7aeh6quc	78	7	was	be	VBD
cord-017917-7aeh6quc	78	8	attributed	attribute	VBN
cord-017917-7aeh6quc	78	9	to	to	IN
cord-017917-7aeh6quc	78	10	the	the	DT
cord-017917-7aeh6quc	78	11	presence	presence	NN
cord-017917-7aeh6quc	78	12	of	of	IN
cord-017917-7aeh6quc	78	13	polymorphonuclear	polymorphonuclear	JJ
cord-017917-7aeh6quc	78	14	cell	cell	NN
cord-017917-7aeh6quc	78	15	infiltrates	infiltrate	VBZ
cord-017917-7aeh6quc	78	16	in	in	IN
cord-017917-7aeh6quc	78	17	response	response	NN
cord-017917-7aeh6quc	78	18	to	to	IN
cord-017917-7aeh6quc	78	19	infection	infection	NN
cord-017917-7aeh6quc	78	20	(	(	-LRB-
cord-017917-7aeh6quc	78	21	51	51	CD
cord-017917-7aeh6quc	78	22	,	,	,
cord-017917-7aeh6quc	78	23	53	53	CD
cord-017917-7aeh6quc	78	24	)	)	-RRB-
cord-017917-7aeh6quc	78	25	.	.	.
cord-017917-7aeh6quc	79	1	Neutrophil	Neutrophil	NNP
cord-017917-7aeh6quc	79	2	synthesis	synthesis	NN
cord-017917-7aeh6quc	79	3	of	of	IN
cord-017917-7aeh6quc	79	4	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	79	5	differs	differ	VBZ
cord-017917-7aeh6quc	79	6	from	from	IN
cord-017917-7aeh6quc	79	7	other	other	JJ
cord-017917-7aeh6quc	79	8	cell	cell	NN
cord-017917-7aeh6quc	79	9	types	type	NNS
cord-017917-7aeh6quc	79	10	in	in	IN
cord-017917-7aeh6quc	79	11	two	two	CD
cord-017917-7aeh6quc	79	12	key	key	JJ
cord-017917-7aeh6quc	79	13	ways	way	NNS
cord-017917-7aeh6quc	79	14	.	.	.
cord-017917-7aeh6quc	80	1	First	first	RB
cord-017917-7aeh6quc	80	2	,	,	,
cord-017917-7aeh6quc	80	3	in	in	IN
cord-017917-7aeh6quc	80	4	contrast	contrast	NN
cord-017917-7aeh6quc	80	5	to	to	IN
cord-017917-7aeh6quc	80	6	mononuclear	mononuclear	JJ
cord-017917-7aeh6quc	80	7	cells	cell	NNS
cord-017917-7aeh6quc	80	8	,	,	,
cord-017917-7aeh6quc	80	9	which	which	WDT
cord-017917-7aeh6quc	80	10	release	release	VBP
cord-017917-7aeh6quc	80	11	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	80	12	directly	directly	RB
cord-017917-7aeh6quc	80	13	into	into	IN
cord-017917-7aeh6quc	80	14	the	the	DT
cord-017917-7aeh6quc	80	15	extracellular	extracellular	JJ
cord-017917-7aeh6quc	80	16	space	space	NN
cord-017917-7aeh6quc	80	17	,	,	,
cord-017917-7aeh6quc	80	18	neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	80	19	store	store	VBP
cord-017917-7aeh6quc	80	20	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	80	21	proenzyme	proenzyme	NNS
cord-017917-7aeh6quc	80	22	in	in	IN
cord-017917-7aeh6quc	80	23	granules	granule	NNS
cord-017917-7aeh6quc	80	24	for	for	IN
cord-017917-7aeh6quc	80	25	release	release	NN
cord-017917-7aeh6quc	80	26	during	during	IN
cord-017917-7aeh6quc	80	27	degranulation	degranulation	NN
cord-017917-7aeh6quc	80	28	(	(	-LRB-
cord-017917-7aeh6quc	80	29	35	35	CD
cord-017917-7aeh6quc	80	30	)	)	-RRB-
cord-017917-7aeh6quc	80	31	,	,	,
cord-017917-7aeh6quc	80	32	therefore	therefore	RB
cord-017917-7aeh6quc	80	33	permitting	permit	VBG
cord-017917-7aeh6quc	80	34	neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	80	35	to	to	TO
cord-017917-7aeh6quc	80	36	rapidly	rapidly	RB
cord-017917-7aeh6quc	80	37	release	release	VB
cord-017917-7aeh6quc	80	38	large	large	JJ
cord-017917-7aeh6quc	80	39	quantities	quantity	NNS
cord-017917-7aeh6quc	80	40	of	of	IN
cord-017917-7aeh6quc	80	41	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	80	42	in	in	IN
cord-017917-7aeh6quc	80	43	the	the	DT
cord-017917-7aeh6quc	80	44	absence	absence	NN
cord-017917-7aeh6quc	80	45	of	of	IN
cord-017917-7aeh6quc	80	46	de	de	NNP
cord-017917-7aeh6quc	80	47	novo	novo	NNP
cord-017917-7aeh6quc	80	48	synthesis	synthesis	NNP
cord-017917-7aeh6quc	80	49	.	.	.
cord-017917-7aeh6quc	81	1	Second	second	JJ
cord-017917-7aeh6quc	81	2	,	,	,
cord-017917-7aeh6quc	81	3	expression	expression	NN
cord-017917-7aeh6quc	81	4	of	of	IN
cord-017917-7aeh6quc	81	5	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	81	6	in	in	IN
cord-017917-7aeh6quc	81	7	neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	81	8	is	be	VBZ
cord-017917-7aeh6quc	81	9	not	not	RB
cord-017917-7aeh6quc	81	10	linked	link	VBN
cord-017917-7aeh6quc	81	11	to	to	TO
cord-017917-7aeh6quc	81	12	co	co	NN
cord-017917-7aeh6quc	81	13	-	-	JJ
cord-017917-7aeh6quc	81	14	expression	expression	NN
cord-017917-7aeh6quc	81	15	of	of	IN
cord-017917-7aeh6quc	81	16	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	81	17	as	as	IN
cord-017917-7aeh6quc	81	18	is	be	VBZ
cord-017917-7aeh6quc	81	19	the	the	DT
cord-017917-7aeh6quc	81	20	case	case	NN
cord-017917-7aeh6quc	81	21	for	for	IN
cord-017917-7aeh6quc	81	22	T	t	NN
cord-017917-7aeh6quc	81	23	cells	cell	NNS
cord-017917-7aeh6quc	81	24	(	(	-LRB-
cord-017917-7aeh6quc	81	25	35	35	CD
cord-017917-7aeh6quc	81	26	)	)	-RRB-
cord-017917-7aeh6quc	81	27	.	.	.
cord-017917-7aeh6quc	82	1	Thus	thus	RB
cord-017917-7aeh6quc	82	2	,	,	,
cord-017917-7aeh6quc	82	3	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	82	4	from	from	IN
cord-017917-7aeh6quc	82	5	neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	82	6	is	be	VBZ
cord-017917-7aeh6quc	82	7	regulated	regulate	VBN
cord-017917-7aeh6quc	82	8	at	at	IN
cord-017917-7aeh6quc	82	9	the	the	DT
cord-017917-7aeh6quc	82	10	level	level	NN
cord-017917-7aeh6quc	82	11	of	of	IN
cord-017917-7aeh6quc	82	12	degranulation	degranulation	NN
cord-017917-7aeh6quc	82	13	as	as	IN
cord-017917-7aeh6quc	82	14	opposed	oppose	VBN
cord-017917-7aeh6quc	82	15	to	to	IN
cord-017917-7aeh6quc	82	16	gene	gene	NN
cord-017917-7aeh6quc	82	17	transcription	transcription	NN
cord-017917-7aeh6quc	82	18	and	and	CC
cord-017917-7aeh6quc	82	19	co	co	NN
cord-017917-7aeh6quc	82	20	-	-	NN
cord-017917-7aeh6quc	82	21	expression	expression	NN
cord-017917-7aeh6quc	82	22	of	of	IN
cord-017917-7aeh6quc	82	23	TIMPs	TIMPs	NNP
cord-017917-7aeh6quc	82	24	.	.	.
cord-017917-7aeh6quc	83	1	These	these	DT
cord-017917-7aeh6quc	83	2	data	datum	NNS
cord-017917-7aeh6quc	83	3	suggest	suggest	VBP
cord-017917-7aeh6quc	83	4	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	83	5	is	be	VBZ
cord-017917-7aeh6quc	83	6	likely	likely	RB
cord-017917-7aeh6quc	83	7	released	release	VBN
cord-017917-7aeh6quc	83	8	from	from	IN
cord-017917-7aeh6quc	83	9	both	both	DT
cord-017917-7aeh6quc	83	10	mononuclear	mononuclear	JJ
cord-017917-7aeh6quc	83	11	and	and	CC
cord-017917-7aeh6quc	83	12	polymorphonuclear	polymorphonuclear	JJ
cord-017917-7aeh6quc	83	13	infiltrates	infiltrate	VBZ
cord-017917-7aeh6quc	83	14	during	during	IN
cord-017917-7aeh6quc	83	15	JHMV	JHMV	NNP
cord-017917-7aeh6quc	83	16	infection	infection	NN
cord-017917-7aeh6quc	83	17	.	.	.
cord-017917-7aeh6quc	84	1	Thus	thus	RB
cord-017917-7aeh6quc	84	2	,	,	,
cord-017917-7aeh6quc	84	3	with	with	IN
cord-017917-7aeh6quc	84	4	the	the	DT
cord-017917-7aeh6quc	84	5	exception	exception	NN
cord-017917-7aeh6quc	84	6	that	that	WDT
cord-017917-7aeh6quc	84	7	MMP-7	MMP-7	NNP
cord-017917-7aeh6quc	84	8	was	be	VBD
cord-017917-7aeh6quc	84	9	not	not	RB
cord-017917-7aeh6quc	84	10	detected	detect	VBN
cord-017917-7aeh6quc	84	11	during	during	IN
cord-017917-7aeh6quc	84	12	MHV	MHV	NNP
cord-017917-7aeh6quc	84	13	infection	infection	NN
cord-017917-7aeh6quc	84	14	(	(	-LRB-
cord-017917-7aeh6quc	84	15	51	51	CD
cord-017917-7aeh6quc	84	16	)	)	-RRB-
cord-017917-7aeh6quc	84	17	,	,	,
cord-017917-7aeh6quc	84	18	the	the	DT
cord-017917-7aeh6quc	84	19	overall	overall	JJ
cord-017917-7aeh6quc	84	20	expression	expression	NN
cord-017917-7aeh6quc	84	21	patterns	pattern	NNS
cord-017917-7aeh6quc	84	22	for	for	IN
cord-017917-7aeh6quc	84	23	both	both	DT
cord-017917-7aeh6quc	84	24	MMPs	mmp	NNS
cord-017917-7aeh6quc	84	25	(	(	-LRB-
cord-017917-7aeh6quc	84	26	-3	-3	NNP
cord-017917-7aeh6quc	84	27	,	,	,
cord-017917-7aeh6quc	84	28	-9	-9	NNP
cord-017917-7aeh6quc	84	29	and	and	CC
cord-017917-7aeh6quc	84	30	-12	-12	LS
cord-017917-7aeh6quc	84	31	)	)	-RRB-
cord-017917-7aeh6quc	84	32	and	and	CC
cord-017917-7aeh6quc	84	33	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	84	34	during	during	IN
cord-017917-7aeh6quc	84	35	MHV	MHV	NNP
cord-017917-7aeh6quc	84	36	infection	infection	NN
cord-017917-7aeh6quc	84	37	,	,	,
cord-017917-7aeh6quc	84	38	EAE	EAE	NNP
cord-017917-7aeh6quc	84	39	and	and	CC
cord-017917-7aeh6quc	84	40	MS	MS	NNP
cord-017917-7aeh6quc	84	41	are	be	VBP
cord-017917-7aeh6quc	84	42	extremely	extremely	RB
cord-017917-7aeh6quc	84	43	similar	similar	JJ
cord-017917-7aeh6quc	84	44	.	.	.
cord-017917-7aeh6quc	85	1	Linkage	linkage	NN
cord-017917-7aeh6quc	85	2	between	between	IN
cord-017917-7aeh6quc	85	3	MMP	MMP	NNP
cord-017917-7aeh6quc	85	4	/	/	SYM
cord-017917-7aeh6quc	85	5	TIMP	TIMP	NNP
cord-017917-7aeh6quc	85	6	expression	expression	NN
cord-017917-7aeh6quc	85	7	during	during	IN
cord-017917-7aeh6quc	85	8	demyelinating	demyelinate	VBG
cord-017917-7aeh6quc	85	9	disease	disease	NN
cord-017917-7aeh6quc	85	10	has	have	VBZ
cord-017917-7aeh6quc	85	11	been	be	VBN
cord-017917-7aeh6quc	85	12	well	well	RB
cord-017917-7aeh6quc	85	13	chronicled	chronicle	VBN
cord-017917-7aeh6quc	85	14	(	(	-LRB-
cord-017917-7aeh6quc	85	15	32,38,51	32,38,51	CD
cord-017917-7aeh6quc	85	16	)	)	-RRB-
cord-017917-7aeh6quc	85	17	.	.	.
cord-017917-7aeh6quc	86	1	By	by	IN
cord-017917-7aeh6quc	86	2	contrast	contrast	NN
cord-017917-7aeh6quc	86	3	,	,	,
cord-017917-7aeh6quc	86	4	determining	determine	VBG
cord-017917-7aeh6quc	86	5	a	a	DT
cord-017917-7aeh6quc	86	6	definitive	definitive	JJ
cord-017917-7aeh6quc	86	7	role	role	NN
cord-017917-7aeh6quc	86	8	for	for	IN
cord-017917-7aeh6quc	86	9	MMPs	mmp	NNS
cord-017917-7aeh6quc	86	10	during	during	IN
cord-017917-7aeh6quc	86	11	demyelinating	demyelinate	VBG
cord-017917-7aeh6quc	86	12	disease	disease	NN
cord-017917-7aeh6quc	86	13	has	have	VBZ
cord-017917-7aeh6quc	86	14	proven	prove	VBN
cord-017917-7aeh6quc	86	15	to	to	TO
cord-017917-7aeh6quc	86	16	be	be	VB
cord-017917-7aeh6quc	86	17	far	far	RB
cord-017917-7aeh6quc	86	18	more	more	RBR
cord-017917-7aeh6quc	86	19	elusive	elusive	JJ
cord-017917-7aeh6quc	86	20	.	.	.
cord-017917-7aeh6quc	87	1	During	during	IN
cord-017917-7aeh6quc	87	2	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	87	3	processes	process	NNS
cord-017917-7aeh6quc	87	4	within	within	IN
cord-017917-7aeh6quc	87	5	the	the	DT
cord-017917-7aeh6quc	87	6	CNS	CNS	NNP
cord-017917-7aeh6quc	87	7	,	,	,
cord-017917-7aeh6quc	87	8	MMPs	mmp	NNS
cord-017917-7aeh6quc	87	9	most	most	RBS
cord-017917-7aeh6quc	87	10	likely	likely	RB
cord-017917-7aeh6quc	87	11	play	play	VB
cord-017917-7aeh6quc	87	12	two	two	CD
cord-017917-7aeh6quc	87	13	key	key	JJ
cord-017917-7aeh6quc	87	14	roles	role	NNS
cord-017917-7aeh6quc	87	15	:	:	:
cord-017917-7aeh6quc	88	1	1	1	LS
cord-017917-7aeh6quc	88	2	)	)	-RRB-
cord-017917-7aeh6quc	88	3	Breaking	break	VBG
cord-017917-7aeh6quc	88	4	down	down	RP
cord-017917-7aeh6quc	88	5	the	the	DT
cord-017917-7aeh6quc	88	6	basal	basal	NN
cord-017917-7aeh6quc	88	7	lamina	lamina	NN
cord-017917-7aeh6quc	88	8	surrounding	surround	VBG
cord-017917-7aeh6quc	88	9	the	the	DT
cord-017917-7aeh6quc	88	10	blood	blood	NN
cord-017917-7aeh6quc	88	11	brain	brain	NN
cord-017917-7aeh6quc	88	12	barrier	barrier	NN
cord-017917-7aeh6quc	88	13	,	,	,
cord-017917-7aeh6quc	88	14	thereby	thereby	RB
cord-017917-7aeh6quc	88	15	allowing	allow	VBG
cord-017917-7aeh6quc	88	16	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	88	17	cells	cell	NNS
cord-017917-7aeh6quc	88	18	to	to	TO
cord-017917-7aeh6quc	88	19	enter	enter	VB
cord-017917-7aeh6quc	88	20	the	the	DT
cord-017917-7aeh6quc	88	21	CNS	CNS	NNP
cord-017917-7aeh6quc	88	22	(	(	-LRB-
cord-017917-7aeh6quc	88	23	35	35	CD
cord-017917-7aeh6quc	88	24	)	)	-RRB-
cord-017917-7aeh6quc	88	25	;	;	:
cord-017917-7aeh6quc	88	26	and	and	CC
cord-017917-7aeh6quc	88	27	2	2	LS
cord-017917-7aeh6quc	88	28	)	)	-RRB-
cord-017917-7aeh6quc	88	29	breaking	break	VBG
cord-017917-7aeh6quc	88	30	down	down	RP
cord-017917-7aeh6quc	88	31	connective	connective	JJ
cord-017917-7aeh6quc	88	32	tissues	tissue	NNS
cord-017917-7aeh6quc	88	33	linking	link	VBG
cord-017917-7aeh6quc	88	34	tightly	tightly	RB
cord-017917-7aeh6quc	88	35	packed	pack	VBN
cord-017917-7aeh6quc	88	36	CNS	CNS	NNP
cord-017917-7aeh6quc	88	37	resident	resident	NN
cord-017917-7aeh6quc	88	38	cells	cell	NNS
cord-017917-7aeh6quc	88	39	,	,	,
cord-017917-7aeh6quc	88	40	thereby	thereby	RB
cord-017917-7aeh6quc	88	41	allowing	allow	VBG
cord-017917-7aeh6quc	88	42	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	88	43	cells	cell	NNS
cord-017917-7aeh6quc	88	44	to	to	TO
cord-017917-7aeh6quc	88	45	migrate	migrate	VB
cord-017917-7aeh6quc	88	46	along	along	IN
cord-017917-7aeh6quc	88	47	chemokine	chemokine	NN
cord-017917-7aeh6quc	88	48	gradients	gradient	NNS
cord-017917-7aeh6quc	88	49	towards	towards	IN
cord-017917-7aeh6quc	88	50	the	the	DT
cord-017917-7aeh6quc	88	51	sites	site	NNS
cord-017917-7aeh6quc	88	52	of	of	IN
cord-017917-7aeh6quc	88	53	infection	infection	NN
cord-017917-7aeh6quc	88	54	/	/	SYM
cord-017917-7aeh6quc	88	55	injury	injury	NN
cord-017917-7aeh6quc	88	56	(	(	-LRB-
cord-017917-7aeh6quc	88	57	18	18	CD
cord-017917-7aeh6quc	88	58	,	,	,
cord-017917-7aeh6quc	88	59	50	50	CD
cord-017917-7aeh6quc	88	60	)	)	-RRB-
cord-017917-7aeh6quc	88	61	.	.	.
cord-017917-7aeh6quc	89	1	Other	other	JJ
cord-017917-7aeh6quc	89	2	key	key	JJ
cord-017917-7aeh6quc	89	3	mechanisms	mechanism	NNS
cord-017917-7aeh6quc	89	4	in	in	IN
cord-017917-7aeh6quc	89	5	the	the	DT
cord-017917-7aeh6quc	89	6	genesis	genesis	NN
cord-017917-7aeh6quc	89	7	of	of	IN
cord-017917-7aeh6quc	89	8	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	89	9	demyelination	demyelination	NN
cord-017917-7aeh6quc	89	10	have	have	VBP
cord-017917-7aeh6quc	89	11	been	be	VBN
cord-017917-7aeh6quc	89	12	associated	associate	VBN
cord-017917-7aeh6quc	89	13	with	with	IN
cord-017917-7aeh6quc	89	14	MMPs	mmp	NNS
cord-017917-7aeh6quc	89	15	.	.	.
cord-017917-7aeh6quc	90	1	These	these	DT
cord-017917-7aeh6quc	90	2	include	include	VBP
cord-017917-7aeh6quc	90	3	activation	activation	NN
cord-017917-7aeh6quc	90	4	of	of	IN
cord-017917-7aeh6quc	90	5	cytokines	cytokine	NNS
cord-017917-7aeh6quc	90	6	and	and	CC
cord-017917-7aeh6quc	90	7	chemokines	chemokine	NNS
cord-017917-7aeh6quc	90	8	,	,	,
cord-017917-7aeh6quc	90	9	such	such	JJ
cord-017917-7aeh6quc	90	10	as	as	IN
cord-017917-7aeh6quc	90	11	the	the	DT
cord-017917-7aeh6quc	90	12	conversion	conversion	NN
cord-017917-7aeh6quc	90	13	of	of	IN
cord-017917-7aeh6quc	90	14	TNF	TNF	NNP
cord-017917-7aeh6quc	90	15	-	-	:
cord-017917-7aeh6quc	90	16	a	a	NN
cord-017917-7aeh6quc	90	17	from	from	IN
cord-017917-7aeh6quc	90	18	pro	pro	JJ
cord-017917-7aeh6quc	90	19	to	to	IN
cord-017917-7aeh6quc	90	20	active	active	JJ
cord-017917-7aeh6quc	90	21	form	form	NN
cord-017917-7aeh6quc	90	22	(	(	-LRB-
cord-017917-7aeh6quc	90	23	8)	8)	NN
cord-017917-7aeh6quc	90	24	and	and	CC
cord-017917-7aeh6quc	90	25	increasing	increase	VBG
cord-017917-7aeh6quc	90	26	the	the	DT
cord-017917-7aeh6quc	90	27	potency	potency	NN
cord-017917-7aeh6quc	90	28	of	of	IN
cord-017917-7aeh6quc	90	29	the	the	DT
cord-017917-7aeh6quc	90	30	chemokine	chemokine	NN
cord-017917-7aeh6quc	90	31	.	.	.
cord-017917-7aeh6quc	91	1	Furthermore	furthermore	RB
cord-017917-7aeh6quc	91	2	,	,	,
cord-017917-7aeh6quc	91	3	activated	activate	VBN
cord-017917-7aeh6quc	91	4	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	91	5	can	can	MD
cord-017917-7aeh6quc	91	6	convert	convert	VB
cord-017917-7aeh6quc	91	7	pro	pro	JJ
cord-017917-7aeh6quc	91	8	-	-	JJ
cord-017917-7aeh6quc	91	9	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	91	10	into	into	IN
cord-017917-7aeh6quc	91	11	it	-PRON-	PRP
cord-017917-7aeh6quc	91	12	active	active	JJ
cord-017917-7aeh6quc	91	13	form	form	NN
cord-017917-7aeh6quc	91	14	(	(	-LRB-
cord-017917-7aeh6quc	91	15	13	13	CD
cord-017917-7aeh6quc	91	16	)	)	-RRB-
cord-017917-7aeh6quc	91	17	.	.	.
cord-017917-7aeh6quc	92	1	Thus	thus	RB
cord-017917-7aeh6quc	92	2	MMP-3	MMP-3	NNP
cord-017917-7aeh6quc	92	3	produced	produce	VBN
cord-017917-7aeh6quc	92	4	by	by	IN
cord-017917-7aeh6quc	92	5	CNS	CNS	NNP
cord-017917-7aeh6quc	92	6	resident	resident	NN
cord-017917-7aeh6quc	92	7	cells	cell	NNS
cord-017917-7aeh6quc	92	8	may	may	MD
cord-017917-7aeh6quc	92	9	be	be	VB
cord-017917-7aeh6quc	92	10	involved	involve	VBN
cord-017917-7aeh6quc	92	11	in	in	IN
cord-017917-7aeh6quc	92	12	activating	activate	VBG
cord-017917-7aeh6quc	92	13	pro	pro	JJ
cord-017917-7aeh6quc	92	14	-	-	JJ
cord-017917-7aeh6quc	92	15	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	92	16	synthesized	synthesize	VBN
cord-017917-7aeh6quc	92	17	by	by	IN
cord-017917-7aeh6quc	92	18	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	92	19	cells	cell	NNS
cord-017917-7aeh6quc	92	20	.	.	.
cord-017917-7aeh6quc	93	1	Activation	activation	NN
cord-017917-7aeh6quc	93	2	of	of	IN
cord-017917-7aeh6quc	93	3	these	these	DT
cord-017917-7aeh6quc	93	4	proinflammatory	proinflammatory	JJ
cord-017917-7aeh6quc	93	5	proteins	protein	NNS
cord-017917-7aeh6quc	93	6	by	by	IN
cord-017917-7aeh6quc	93	7	MMPs	mmps	NN
cord-017917-7aeh6quc	93	8	increases	increase	VBZ
cord-017917-7aeh6quc	93	9	the	the	DT
cord-017917-7aeh6quc	93	10	potential	potential	NN
cord-017917-7aeh6quc	93	11	for	for	IN
cord-017917-7aeh6quc	93	12	immune	immune	JJ
cord-017917-7aeh6quc	93	13	mediated	mediate	VBN
cord-017917-7aeh6quc	93	14	damage	damage	NN
cord-017917-7aeh6quc	93	15	to	to	IN
cord-017917-7aeh6quc	93	16	the	the	DT
cord-017917-7aeh6quc	93	17	CNS	CNS	NNP
cord-017917-7aeh6quc	93	18	.	.	.
cord-017917-7aeh6quc	94	1	A	a	DT
cord-017917-7aeh6quc	94	2	number	number	NN
cord-017917-7aeh6quc	94	3	of	of	IN
cord-017917-7aeh6quc	94	4	MMPs	mmp	NNS
cord-017917-7aeh6quc	94	5	including	include	VBG
cord-017917-7aeh6quc	94	6	-3	-3	NNP
cord-017917-7aeh6quc	94	7	,	,	,
cord-017917-7aeh6quc	94	8	-9	-9	NNP
cord-017917-7aeh6quc	94	9	,	,	,
cord-017917-7aeh6quc	94	10	and	and	CC
cord-017917-7aeh6quc	94	11	-12	-12	NNS
cord-017917-7aeh6quc	94	12	,	,	,
cord-017917-7aeh6quc	94	13	which	which	WDT
cord-017917-7aeh6quc	94	14	are	be	VBP
cord-017917-7aeh6quc	94	15	common	common	JJ
cord-017917-7aeh6quc	94	16	to	to	IN
cord-017917-7aeh6quc	94	17	many	many	JJ
cord-017917-7aeh6quc	94	18	demyelinating	demyelinating	JJ
cord-017917-7aeh6quc	94	19	diseases	disease	NNS
cord-017917-7aeh6quc	94	20	,	,	,
cord-017917-7aeh6quc	94	21	are	be	VBP
cord-017917-7aeh6quc	94	22	capable	capable	JJ
cord-017917-7aeh6quc	94	23	of	of	IN
cord-017917-7aeh6quc	94	24	breaking	break	VBG
cord-017917-7aeh6quc	94	25	down	down	RP
cord-017917-7aeh6quc	94	26	proteins	protein	NNS
cord-017917-7aeh6quc	94	27	of	of	IN
cord-017917-7aeh6quc	94	28	the	the	DT
cord-017917-7aeh6quc	94	29	myelin	myelin	NN
cord-017917-7aeh6quc	94	30	sheath	sheath	NN
cord-017917-7aeh6quc	94	31	(	(	-LRB-
cord-017917-7aeh6quc	94	32	8	8	CD
cord-017917-7aeh6quc	94	33	,	,	,
cord-017917-7aeh6quc	94	34	9	9	CD
cord-017917-7aeh6quc	94	35	,	,	,
cord-017917-7aeh6quc	94	36	39	39	CD
cord-017917-7aeh6quc	94	37	)	)	-RRB-
cord-017917-7aeh6quc	94	38	.	.	.
cord-017917-7aeh6quc	95	1	The	the	DT
cord-017917-7aeh6quc	95	2	consequences	consequence	NNS
cord-017917-7aeh6quc	95	3	of	of	IN
cord-017917-7aeh6quc	95	4	this	this	DT
cord-017917-7aeh6quc	95	5	are	be	VBP
cord-017917-7aeh6quc	95	6	two	two	CD
cord-017917-7aeh6quc	95	7	fold	fold	JJ
cord-017917-7aeh6quc	95	8	.	.	.
cord-017917-7aeh6quc	96	1	First	first	RB
cord-017917-7aeh6quc	96	2	,	,	,
cord-017917-7aeh6quc	96	3	induction	induction	NN
cord-017917-7aeh6quc	96	4	of	of	IN
cord-017917-7aeh6quc	96	5	an	an	DT
cord-017917-7aeh6quc	96	6	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	96	7	response	response	NN
cord-017917-7aeh6quc	96	8	to	to	IN
cord-017917-7aeh6quc	96	9	a	a	DT
cord-017917-7aeh6quc	96	10	foreign	foreign	JJ
cord-017917-7aeh6quc	96	11	antigen	antigen	NN
cord-017917-7aeh6quc	96	12	within	within	IN
cord-017917-7aeh6quc	96	13	the	the	DT
cord-017917-7aeh6quc	96	14	CNS	CNS	NNP
cord-017917-7aeh6quc	96	15	may	may	MD
cord-017917-7aeh6quc	96	16	nonspecifically	nonspecifically	RB
cord-017917-7aeh6quc	96	17	initiate	initiate	VB
cord-017917-7aeh6quc	96	18	destruction	destruction	NN
cord-017917-7aeh6quc	96	19	of	of	IN
cord-017917-7aeh6quc	96	20	the	the	DT
cord-017917-7aeh6quc	96	21	myelin	myelin	NN
cord-017917-7aeh6quc	96	22	sheath	sheath	NN
cord-017917-7aeh6quc	96	23	through	through	IN
cord-017917-7aeh6quc	96	24	the	the	DT
cord-017917-7aeh6quc	96	25	release	release	NN
cord-017917-7aeh6quc	96	26	of	of	IN
cord-017917-7aeh6quc	96	27	MMPs	mmp	NNS
cord-017917-7aeh6quc	96	28	.	.	.
cord-017917-7aeh6quc	97	1	Second	second	JJ
cord-017917-7aeh6quc	97	2	,	,	,
cord-017917-7aeh6quc	97	3	generation	generation	NN
cord-017917-7aeh6quc	97	4	of	of	IN
cord-017917-7aeh6quc	97	5	potential	potential	JJ
cord-017917-7aeh6quc	97	6	autoreactive	autoreactive	JJ
cord-017917-7aeh6quc	97	7	self	self	NN
cord-017917-7aeh6quc	97	8	-	-	HYPH
cord-017917-7aeh6quc	97	9	antigens	antigen	NNS
cord-017917-7aeh6quc	97	10	by	by	IN
cord-017917-7aeh6quc	97	11	MMP	MMP	NNP
cord-017917-7aeh6quc	97	12	mediated	mediate	VBN
cord-017917-7aeh6quc	97	13	breakdown	breakdown	NN
cord-017917-7aeh6quc	97	14	of	of	IN
cord-017917-7aeh6quc	97	15	myelin	myelin	NN
cord-017917-7aeh6quc	97	16	proteins	protein	NNS
cord-017917-7aeh6quc	97	17	may	may	MD
cord-017917-7aeh6quc	97	18	initiate	initiate	VB
cord-017917-7aeh6quc	97	19	specific	specific	JJ
cord-017917-7aeh6quc	97	20	responses	response	NNS
cord-017917-7aeh6quc	97	21	against	against	IN
cord-017917-7aeh6quc	97	22	oligodendroglia	oligodendroglia	NNP
cord-017917-7aeh6quc	97	23	resulting	result	VBG
cord-017917-7aeh6quc	97	24	in	in	IN
cord-017917-7aeh6quc	97	25	additional	additional	JJ
cord-017917-7aeh6quc	97	26	demyelination	demyelination	NN
cord-017917-7aeh6quc	97	27	(	(	-LRB-
cord-017917-7aeh6quc	97	28	36	36	CD
cord-017917-7aeh6quc	97	29	,	,	,
cord-017917-7aeh6quc	97	30	39	39	CD
cord-017917-7aeh6quc	97	31	)	)	-RRB-
cord-017917-7aeh6quc	97	32	.	.	.
cord-017917-7aeh6quc	98	1	Of	of	IN
cord-017917-7aeh6quc	98	2	the	the	DT
cord-017917-7aeh6quc	98	3	MMPs	mmp	NNS
cord-017917-7aeh6quc	98	4	associated	associate	VBN
cord-017917-7aeh6quc	98	5	with	with	IN
cord-017917-7aeh6quc	98	6	MHV	MHV	NNP
cord-017917-7aeh6quc	98	7	infection	infection	NN
cord-017917-7aeh6quc	98	8	of	of	IN
cord-017917-7aeh6quc	98	9	the	the	DT
cord-017917-7aeh6quc	98	10	CNS	CNS	NNP
cord-017917-7aeh6quc	98	11	,	,	,
cord-017917-7aeh6quc	98	12	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	98	13	and	and	CC
cord-017917-7aeh6quc	98	14	its	-PRON-	PRP$
cord-017917-7aeh6quc	98	15	specific	specific	JJ
cord-017917-7aeh6quc	98	16	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	98	17	,	,	,
cord-017917-7aeh6quc	98	18	TIMP	TIMP	NNP
cord-017917-7aeh6quc	98	19	-	-	HYPH
cord-017917-7aeh6quc	98	20	I	I	NNP
cord-017917-7aeh6quc	98	21	,	,	,
cord-017917-7aeh6quc	98	22	are	be	VBP
cord-017917-7aeh6quc	98	23	of	of	IN
cord-017917-7aeh6quc	98	24	particular	particular	JJ
cord-017917-7aeh6quc	98	25	interest	interest	NN
cord-017917-7aeh6quc	98	26	for	for	IN
cord-017917-7aeh6quc	98	27	several	several	JJ
cord-017917-7aeh6quc	98	28	reasons	reason	NNS
cord-017917-7aeh6quc	98	29	.	.	.
cord-017917-7aeh6quc	99	1	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	99	2	and	and	CC
cord-017917-7aeh6quc	99	3	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	99	4	are	be	VBP
cord-017917-7aeh6quc	99	5	produced	produce	VBN
cord-017917-7aeh6quc	99	6	by	by	IN
cord-017917-7aeh6quc	99	7	both	both	CC
cord-017917-7aeh6quc	99	8	activated	activate	VBN
cord-017917-7aeh6quc	99	9	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	99	10	as	as	RB
cord-017917-7aeh6quc	99	11	well	well	RB
cord-017917-7aeh6quc	99	12	as	as	IN
cord-017917-7aeh6quc	99	13	CNS	CNS	NNP
cord-017917-7aeh6quc	99	14	resident	resident	NN
cord-017917-7aeh6quc	99	15	cells	cell	NNS
cord-017917-7aeh6quc	99	16	(	(	-LRB-
cord-017917-7aeh6quc	99	17	19	19	CD
cord-017917-7aeh6quc	99	18	,	,	,
cord-017917-7aeh6quc	99	19	35	35	CD
cord-017917-7aeh6quc	99	20	,	,	,
cord-017917-7aeh6quc	99	21	47	47	CD
cord-017917-7aeh6quc	99	22	)	)	-RRB-
cord-017917-7aeh6quc	99	23	.	.	.
cord-017917-7aeh6quc	100	1	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	100	2	is	be	VBZ
cord-017917-7aeh6quc	100	3	specific	specific	JJ
cord-017917-7aeh6quc	100	4	for	for	IN
cord-017917-7aeh6quc	100	5	type	type	NN
cord-017917-7aeh6quc	100	6	IV	IV	NNP
cord-017917-7aeh6quc	100	7	collagens	collagen	NNS
cord-017917-7aeh6quc	100	8	,	,	,
cord-017917-7aeh6quc	100	9	which	which	WDT
cord-017917-7aeh6quc	100	10	make	make	VBP
cord-017917-7aeh6quc	100	11	up	up	RP
cord-017917-7aeh6quc	100	12	the	the	DT
cord-017917-7aeh6quc	100	13	basement	basement	NN
cord-017917-7aeh6quc	100	14	membrane	membrane	NN
cord-017917-7aeh6quc	100	15	surrounding	surround	VBG
cord-017917-7aeh6quc	100	16	the	the	DT
cord-017917-7aeh6quc	100	17	blood	blood	NN
cord-017917-7aeh6quc	100	18	brain	brain	NN
cord-017917-7aeh6quc	100	19	barrier	barrier	NN
cord-017917-7aeh6quc	100	20	(	(	-LRB-
cord-017917-7aeh6quc	100	21	49	49	CD
cord-017917-7aeh6quc	100	22	)	)	-RRB-
cord-017917-7aeh6quc	100	23	.	.	.
cord-017917-7aeh6quc	101	1	This	this	DT
cord-017917-7aeh6quc	101	2	suggests	suggest	VBZ
cord-017917-7aeh6quc	101	3	that	that	IN
cord-017917-7aeh6quc	101	4	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	101	5	contributes	contribute	VBZ
cord-017917-7aeh6quc	101	6	to	to	IN
cord-017917-7aeh6quc	101	7	the	the	DT
cord-017917-7aeh6quc	101	8	ability	ability	NN
cord-017917-7aeh6quc	101	9	of	of	IN
cord-017917-7aeh6quc	101	10	activated	activate	VBN
cord-017917-7aeh6quc	101	11	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	101	12	cells	cell	NNS
cord-017917-7aeh6quc	101	13	to	to	TO
cord-017917-7aeh6quc	101	14	cross	cross	VB
cord-017917-7aeh6quc	101	15	this	this	DT
cord-017917-7aeh6quc	101	16	barrier	barrier	NN
cord-017917-7aeh6quc	101	17	.	.	.
cord-017917-7aeh6quc	102	1	Support	support	NN
cord-017917-7aeh6quc	102	2	for	for	IN
cord-017917-7aeh6quc	102	3	the	the	DT
cord-017917-7aeh6quc	102	4	role	role	NN
cord-017917-7aeh6quc	102	5	of	of	IN
cord-017917-7aeh6quc	102	6	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	102	7	in	in	IN
cord-017917-7aeh6quc	102	8	T	t	NN
cord-017917-7aeh6quc	102	9	cell	cell	NN
cord-017917-7aeh6quc	102	10	trafficking	trafficking	NN
cord-017917-7aeh6quc	102	11	comes	come	VBZ
cord-017917-7aeh6quc	102	12	from	from	IN
cord-017917-7aeh6quc	102	13	MS	MS	NNP
cord-017917-7aeh6quc	102	14	patients	patient	NNS
cord-017917-7aeh6quc	102	15	undergoing	undergo	VBG
cord-017917-7aeh6quc	102	16	IFN-13	ifn-13	JJ
cord-017917-7aeh6quc	102	17	treatment	treatment	NN
cord-017917-7aeh6quc	102	18	,	,	,
cord-017917-7aeh6quc	102	19	one	one	CD
cord-017917-7aeh6quc	102	20	of	of	IN
cord-017917-7aeh6quc	102	21	the	the	DT
cord-017917-7aeh6quc	102	22	few	few	JJ
cord-017917-7aeh6quc	102	23	therapeutics	therapeutic	NNS
cord-017917-7aeh6quc	102	24	shown	show	VBN
cord-017917-7aeh6quc	102	25	to	to	TO
cord-017917-7aeh6quc	102	26	have	have	VB
cord-017917-7aeh6quc	102	27	a	a	DT
cord-017917-7aeh6quc	102	28	positive	positive	JJ
cord-017917-7aeh6quc	102	29	effect	effect	NN
cord-017917-7aeh6quc	102	30	.	.	.
cord-017917-7aeh6quc	103	1	Although	although	IN
cord-017917-7aeh6quc	103	2	no	no	DT
cord-017917-7aeh6quc	103	3	single	single	JJ
cord-017917-7aeh6quc	103	4	conclusive	conclusive	JJ
cord-017917-7aeh6quc	103	5	mechanism	mechanism	NN
cord-017917-7aeh6quc	103	6	for	for	IN
cord-017917-7aeh6quc	103	7	the	the	DT
cord-017917-7aeh6quc	103	8	anti	anti	JJ
cord-017917-7aeh6quc	103	9	-	-	JJ
cord-017917-7aeh6quc	103	10	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	103	11	activity	activity	NN
cord-017917-7aeh6quc	103	12	of	of	IN
cord-017917-7aeh6quc	103	13	IFN-[3	IFN-[3	NNP
cord-017917-7aeh6quc	103	14	has	have	VBZ
cord-017917-7aeh6quc	103	15	been	be	VBN
cord-017917-7aeh6quc	103	16	demonstrated	demonstrate	VBN
cord-017917-7aeh6quc	103	17	,	,	,
cord-017917-7aeh6quc	103	18	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	103	19	gene	gene	NN
cord-017917-7aeh6quc	103	20	expression	expression	NN
cord-017917-7aeh6quc	103	21	is	be	VBZ
cord-017917-7aeh6quc	103	22	down	down	RB
cord-017917-7aeh6quc	103	23	regulated	regulate	VBN
cord-017917-7aeh6quc	103	24	by	by	IN
cord-017917-7aeh6quc	103	25	45	45	CD
cord-017917-7aeh6quc	103	26	,	,	,
cord-017917-7aeh6quc	103	27	46	46	CD
cord-017917-7aeh6quc	103	28	)	)	-RRB-
cord-017917-7aeh6quc	103	29	.	.	.
cord-017917-7aeh6quc	104	1	Conversely	conversely	RB
cord-017917-7aeh6quc	104	2	,	,	,
cord-017917-7aeh6quc	104	3	TIMP	TIMP	NNP
cord-017917-7aeh6quc	104	4	-	-	HYPH
cord-017917-7aeh6quc	104	5	I	I	NNP
cord-017917-7aeh6quc	104	6	,	,	,
cord-017917-7aeh6quc	104	7	which	which	WDT
cord-017917-7aeh6quc	104	8	inhibits	inhibit	VBZ
cord-017917-7aeh6quc	104	9	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	104	10	,	,	,
cord-017917-7aeh6quc	104	11	is	be	VBZ
cord-017917-7aeh6quc	104	12	up	up	RB
cord-017917-7aeh6quc	104	13	regulated	regulate	VBN
cord-017917-7aeh6quc	104	14	by	by	IN
cord-017917-7aeh6quc	104	15	.	.	.
cord-017917-7aeh6quc	105	1	This	this	DT
cord-017917-7aeh6quc	105	2	suggests	suggest	VBZ
cord-017917-7aeh6quc	105	3	that	that	IN
cord-017917-7aeh6quc	105	4	one	one	CD
cord-017917-7aeh6quc	105	5	of	of	IN
cord-017917-7aeh6quc	105	6	the	the	DT
cord-017917-7aeh6quc	105	7	mechanisms	mechanism	NNS
cord-017917-7aeh6quc	105	8	by	by	IN
cord-017917-7aeh6quc	105	9	which	which	WDT
cord-017917-7aeh6quc	105	10	IFN-13	IFN-13	NNP
cord-017917-7aeh6quc	105	11	works	work	VBZ
cord-017917-7aeh6quc	105	12	is	be	VBZ
cord-017917-7aeh6quc	105	13	through	through	IN
cord-017917-7aeh6quc	105	14	inhibition	inhibition	NN
cord-017917-7aeh6quc	105	15	of	of	IN
cord-017917-7aeh6quc	105	16	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	105	17	mediated	mediate	VBD
cord-017917-7aeh6quc	105	18	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	105	19	cell	cell	NN
cord-017917-7aeh6quc	105	20	trafficking	trafficking	NN
cord-017917-7aeh6quc	105	21	.	.	.
cord-017917-7aeh6quc	106	1	These	these	DT
cord-017917-7aeh6quc	106	2	data	datum	NNS
cord-017917-7aeh6quc	106	3	are	be	VBP
cord-017917-7aeh6quc	106	4	supported	support	VBN
cord-017917-7aeh6quc	106	5	by	by	IN
cord-017917-7aeh6quc	106	6	treatment	treatment	NN
cord-017917-7aeh6quc	106	7	of	of	IN
cord-017917-7aeh6quc	106	8	EAE	EAE	NNP
cord-017917-7aeh6quc	106	9	mice	mouse	NNS
cord-017917-7aeh6quc	106	10	with	with	IN
cord-017917-7aeh6quc	106	11	MMP	MMP	NNP
cord-017917-7aeh6quc	106	12	inhibitors	inhibitor	NNS
cord-017917-7aeh6quc	106	13	,	,	,
cord-017917-7aeh6quc	106	14	which	which	WDT
cord-017917-7aeh6quc	106	15	have	have	VBP
cord-017917-7aeh6quc	106	16	generally	generally	RB
cord-017917-7aeh6quc	106	17	prevented	prevent	VBN
cord-017917-7aeh6quc	106	18	disease	disease	NN
cord-017917-7aeh6quc	106	19	induction	induction	NN
cord-017917-7aeh6quc	106	20	or	or	CC
cord-017917-7aeh6quc	106	21	reduced	reduce	VBN
cord-017917-7aeh6quc	106	22	clinical	clinical	JJ
cord-017917-7aeh6quc	106	23	symptoms	symptom	NNS
cord-017917-7aeh6quc	106	24	when	when	WRB
cord-017917-7aeh6quc	106	25	treatment	treatment	NN
cord-017917-7aeh6quc	106	26	was	be	VBD
cord-017917-7aeh6quc	106	27	initiated	initiate	VBN
cord-017917-7aeh6quc	106	28	after	after	IN
cord-017917-7aeh6quc	106	29	active	active	JJ
cord-017917-7aeh6quc	106	30	disease	disease	NN
cord-017917-7aeh6quc	106	31	was	be	VBD
cord-017917-7aeh6quc	106	32	apparent	apparent	JJ
cord-017917-7aeh6quc	106	33	(	(	-LRB-
cord-017917-7aeh6quc	106	34	17,21,28	17,21,28	CD
cord-017917-7aeh6quc	106	35	)	)	-RRB-
cord-017917-7aeh6quc	106	36	.	.	.
cord-017917-7aeh6quc	107	1	MMP	MMP	NNP
cord-017917-7aeh6quc	107	2	and	and	CC
cord-017917-7aeh6quc	107	3	TIMP	TIMP	NNP
cord-017917-7aeh6quc	107	4	expression	expression	NN
cord-017917-7aeh6quc	107	5	are	be	VBP
cord-017917-7aeh6quc	107	6	closely	closely	RB
cord-017917-7aeh6quc	107	7	associated	associate	VBN
cord-017917-7aeh6quc	107	8	with	with	IN
cord-017917-7aeh6quc	107	9	the	the	DT
cord-017917-7aeh6quc	107	10	human	human	JJ
cord-017917-7aeh6quc	107	11	demyelinating	demyelinating	NN
cord-017917-7aeh6quc	107	12	disease	disease	NN
cord-017917-7aeh6quc	107	13	MS	MS	NNP
cord-017917-7aeh6quc	107	14	as	as	RB
cord-017917-7aeh6quc	107	15	well	well	RB
cord-017917-7aeh6quc	107	16	as	as	IN
cord-017917-7aeh6quc	107	17	experimental	experimental	JJ
cord-017917-7aeh6quc	107	18	animal	animal	NN
cord-017917-7aeh6quc	107	19	models	model	NNS
cord-017917-7aeh6quc	107	20	of	of	IN
cord-017917-7aeh6quc	107	21	demyelinating	demyelinate	VBG
cord-017917-7aeh6quc	107	22	disease	disease	NN
cord-017917-7aeh6quc	107	23	.	.	.
cord-017917-7aeh6quc	108	1	MMP	MMP	NNP
cord-017917-7aeh6quc	108	2	expression	expression	NN
cord-017917-7aeh6quc	108	3	within	within	IN
cord-017917-7aeh6quc	108	4	the	the	DT
cord-017917-7aeh6quc	108	5	CNS	CNS	NNP
cord-017917-7aeh6quc	108	6	is	be	VBZ
cord-017917-7aeh6quc	108	7	most	most	RBS
cord-017917-7aeh6quc	108	8	likely	likely	RB
cord-017917-7aeh6quc	108	9	up	up	RP
cord-017917-7aeh6quc	108	10	regulated	regulate	VBN
cord-017917-7aeh6quc	108	11	by	by	IN
cord-017917-7aeh6quc	108	12	the	the	DT
cord-017917-7aeh6quc	108	13	presence	presence	NN
cord-017917-7aeh6quc	108	14	of	of	IN
cord-017917-7aeh6quc	108	15	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	108	16	cytokines	cytokine	NNS
cord-017917-7aeh6quc	108	17	.	.	.
cord-017917-7aeh6quc	109	1	However	however	RB
cord-017917-7aeh6quc	109	2	,	,	,
cord-017917-7aeh6quc	109	3	as	as	IN
cord-017917-7aeh6quc	109	4	stated	state	VBN
cord-017917-7aeh6quc	109	5	previously	previously	RB
cord-017917-7aeh6quc	109	6	,	,	,
cord-017917-7aeh6quc	109	7	confirmation	confirmation	NN
cord-017917-7aeh6quc	109	8	of	of	IN
cord-017917-7aeh6quc	109	9	a	a	DT
cord-017917-7aeh6quc	109	10	specific	specific	JJ
cord-017917-7aeh6quc	109	11	role	role	NN
cord-017917-7aeh6quc	109	12	for	for	IN
cord-017917-7aeh6quc	109	13	MMPs	mmp	NNS
cord-017917-7aeh6quc	109	14	in	in	IN
cord-017917-7aeh6quc	109	15	the	the	DT
cord-017917-7aeh6quc	109	16	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	109	17	process	process	NN
cord-017917-7aeh6quc	109	18	is	be	VBZ
cord-017917-7aeh6quc	109	19	lacking	lack	VBG
cord-017917-7aeh6quc	109	20	.	.	.
cord-017917-7aeh6quc	110	1	The	the	DT
cord-017917-7aeh6quc	110	2	use	use	NN
cord-017917-7aeh6quc	110	3	of	of	IN
cord-017917-7aeh6quc	110	4	knockout	knockout	NN
cord-017917-7aeh6quc	110	5	mice	mouse	NNS
cord-017917-7aeh6quc	110	6	to	to	TO
cord-017917-7aeh6quc	110	7	determine	determine	VB
cord-017917-7aeh6quc	110	8	the	the	DT
cord-017917-7aeh6quc	110	9	role	role	NN
cord-017917-7aeh6quc	110	10	of	of	IN
cord-017917-7aeh6quc	110	11	specific	specific	JJ
cord-017917-7aeh6quc	110	12	MMPs	mmp	NNS
cord-017917-7aeh6quc	110	13	in	in	IN
cord-017917-7aeh6quc	110	14	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	110	15	responses	response	NNS
cord-017917-7aeh6quc	110	16	have	have	VBP
cord-017917-7aeh6quc	110	17	generated	generate	VBN
cord-017917-7aeh6quc	110	18	mixed	mixed	JJ
cord-017917-7aeh6quc	110	19	results	result	NNS
cord-017917-7aeh6quc	110	20	,	,	,
cord-017917-7aeh6quc	110	21	particularly	particularly	RB
cord-017917-7aeh6quc	110	22	in	in	IN
cord-017917-7aeh6quc	110	23	regard	regard	NN
cord-017917-7aeh6quc	110	24	to	to	IN
cord-017917-7aeh6quc	110	25	blood	blood	NN
cord-017917-7aeh6quc	110	26	brain	brain	NN
cord-017917-7aeh6quc	110	27	barrier	barrier	NN
cord-017917-7aeh6quc	110	28	breakdown	breakdown	NN
cord-017917-7aeh6quc	110	29	and	and	CC
cord-017917-7aeh6quc	110	30	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	110	31	cell	cell	NN
cord-017917-7aeh6quc	110	32	infiltration	infiltration	NN
cord-017917-7aeh6quc	110	33	across	across	IN
cord-017917-7aeh6quc	110	34	endothelial	endothelial	JJ
cord-017917-7aeh6quc	110	35	cell	cell	NN
cord-017917-7aeh6quc	110	36	barriers	barrier	NNS
cord-017917-7aeh6quc	110	37	(	(	-LRB-
cord-017917-7aeh6quc	110	38	1	1	CD
cord-017917-7aeh6quc	110	39	,	,	,
cord-017917-7aeh6quc	110	40	3	3	CD
cord-017917-7aeh6quc	110	41	,	,	,
cord-017917-7aeh6quc	110	42	14	14	CD
cord-017917-7aeh6quc	110	43	,	,	,
cord-017917-7aeh6quc	110	44	29	29	CD
cord-017917-7aeh6quc	110	45	)	)	-RRB-
cord-017917-7aeh6quc	110	46	.	.	.
cord-017917-7aeh6quc	111	1	This	this	DT
cord-017917-7aeh6quc	111	2	may	may	MD
cord-017917-7aeh6quc	111	3	in	in	IN
cord-017917-7aeh6quc	111	4	part	part	NN
cord-017917-7aeh6quc	111	5	be	be	VB
cord-017917-7aeh6quc	111	6	explained	explain	VBN
cord-017917-7aeh6quc	111	7	by	by	IN
cord-017917-7aeh6quc	111	8	the	the	DT
cord-017917-7aeh6quc	111	9	large	large	JJ
cord-017917-7aeh6quc	111	10	number	number	NN
cord-017917-7aeh6quc	111	11	of	of	IN
cord-017917-7aeh6quc	111	12	MMPs	mmp	NNS
cord-017917-7aeh6quc	111	13	with	with	IN
cord-017917-7aeh6quc	111	14	overlapping	overlap	VBG
cord-017917-7aeh6quc	111	15	specificities	specificity	NNS
cord-017917-7aeh6quc	111	16	as	as	RB
cord-017917-7aeh6quc	111	17	well	well	RB
cord-017917-7aeh6quc	111	18	as	as	IN
cord-017917-7aeh6quc	111	19	the	the	DT
cord-017917-7aeh6quc	111	20	presence	presence	NN
cord-017917-7aeh6quc	111	21	of	of	IN
cord-017917-7aeh6quc	111	22	other	other	JJ
cord-017917-7aeh6quc	111	23	proteases	protease	NNS
cord-017917-7aeh6quc	111	24	.	.	.
cord-017917-7aeh6quc	112	1	Thus	thus	RB
cord-017917-7aeh6quc	112	2	,	,	,
cord-017917-7aeh6quc	112	3	although	although	IN
cord-017917-7aeh6quc	112	4	MMP	MMP	NNP
cord-017917-7aeh6quc	112	5	expression	expression	NN
cord-017917-7aeh6quc	112	6	is	be	VBZ
cord-017917-7aeh6quc	112	7	clearly	clearly	RB
cord-017917-7aeh6quc	112	8	associated	associate	VBN
cord-017917-7aeh6quc	112	9	with	with	IN
cord-017917-7aeh6quc	112	10	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	112	11	responses	response	NNS
cord-017917-7aeh6quc	112	12	during	during	IN
cord-017917-7aeh6quc	112	13	demyelinating	demyelinate	VBG
cord-017917-7aeh6quc	112	14	disease	disease	NN
cord-017917-7aeh6quc	112	15	,	,	,
cord-017917-7aeh6quc	112	16	the	the	DT
cord-017917-7aeh6quc	112	17	role	role	NN
cord-017917-7aeh6quc	112	18	of	of	IN
cord-017917-7aeh6quc	112	19	individual	individual	JJ
cord-017917-7aeh6quc	112	20	MMPs	mmp	NNS
cord-017917-7aeh6quc	112	21	as	as	IN
cord-017917-7aeh6quc	112	22	active	active	JJ
cord-017917-7aeh6quc	112	23	participants	participant	NNS
cord-017917-7aeh6quc	112	24	or	or	CC
cord-017917-7aeh6quc	112	25	simply	simply	RB
cord-017917-7aeh6quc	112	26	as	as	IN
cord-017917-7aeh6quc	112	27	markers	marker	NNS
cord-017917-7aeh6quc	112	28	remains	remain	VBZ
cord-017917-7aeh6quc	112	29	to	to	TO
cord-017917-7aeh6quc	112	30	be	be	VB
cord-017917-7aeh6quc	112	31	determined	determine	VBN
cord-017917-7aeh6quc	112	32	.	.	.
cord-017917-7aeh6quc	113	1	Neutrophils	neutrophils	NN
cord-017917-7aeh6quc	113	2	from	from	IN
cord-017917-7aeh6quc	113	3	MMP-9-or	mmp-9-or	NN
cord-017917-7aeh6quc	114	1	neutrophil	neutrophil	NN
cord-017917-7aeh6quc	114	2	elastase	elastase	NN
cord-017917-7aeh6quc	114	3	-	-	HYPH
cord-017917-7aeh6quc	114	4	deficient	deficient	JJ
cord-017917-7aeh6quc	114	5	mice	mouse	NNS
cord-017917-7aeh6quc	114	6	show	show	VBP
cord-017917-7aeh6quc	114	7	no	no	DT
cord-017917-7aeh6quc	114	8	defect	defect	NN
cord-017917-7aeh6quc	114	9	in	in	IN
cord-017917-7aeh6quc	114	10	transendothelial	transendothelial	JJ
cord-017917-7aeh6quc	114	11	migration	migration	NN
cord-017917-7aeh6quc	114	12	under	under	IN
cord-017917-7aeh6quc	114	13	flow	flow	NN
cord-017917-7aeh6quc	114	14	in	in	IN
cord-017917-7aeh6quc	114	15	vitro	vitro	FW
cord-017917-7aeh6quc	114	16	Differential	differential	JJ
cord-017917-7aeh6quc	114	17	matrix	matrix	NN
cord-017917-7aeh6quc	114	18	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	114	19	expression	expression	NN
cord-017917-7aeh6quc	114	20	in	in	IN
cord-017917-7aeh6quc	114	21	cases	case	NNS
cord-017917-7aeh6quc	114	22	of	of	IN
cord-017917-7aeh6quc	114	23	multiple	multiple	JJ
cord-017917-7aeh6quc	114	24	sclerosis	sclerosis	NN
cord-017917-7aeh6quc	114	25	and	and	CC
cord-017917-7aeh6quc	114	26	stroke	stroke	NN
cord-017917-7aeh6quc	114	27	Effects	effect	NNS
cord-017917-7aeh6quc	114	28	of	of	IN
cord-017917-7aeh6quc	114	29	matrix	matrix	NN
cord-017917-7aeh6quc	114	30	metalloproteinase-9	metalloproteinase-9	NNP
cord-017917-7aeh6quc	114	31	gene	gene	NN
cord-017917-7aeh6quc	114	32	knock	knock	NNP
cord-017917-7aeh6quc	114	33	-	-	HYPH
cord-017917-7aeh6quc	114	34	out	out	NN
cord-017917-7aeh6quc	114	35	on	on	IN
cord-017917-7aeh6quc	114	36	the	the	DT
cord-017917-7aeh6quc	114	37	proteolysis	proteolysis	NN
cord-017917-7aeh6quc	114	38	of	of	IN
cord-017917-7aeh6quc	114	39	blood	blood	NN
cord-017917-7aeh6quc	114	40	-	-	HYPH
cord-017917-7aeh6quc	114	41	brain	brain	NN
cord-017917-7aeh6quc	114	42	barrier	barrier	NN
cord-017917-7aeh6quc	114	43	and	and	CC
cord-017917-7aeh6quc	114	44	white	white	JJ
cord-017917-7aeh6quc	114	45	matter	matter	NN
cord-017917-7aeh6quc	114	46	components	component	NNS
cord-017917-7aeh6quc	114	47	after	after	IN
cord-017917-7aeh6quc	114	48	cerebral	cerebral	JJ
cord-017917-7aeh6quc	114	49	ischemia	ischemia	NN
cord-017917-7aeh6quc	114	50	Matrix	Matrix	NNP
cord-017917-7aeh6quc	114	51	Metalloproteinases	Metalloproteinases	NNPS
cord-017917-7aeh6quc	114	52	:	:	:
cord-017917-7aeh6quc	114	53	a	a	DT
cord-017917-7aeh6quc	114	54	review	review	NN
cord-017917-7aeh6quc	114	55	Synergistic	synergistic	JJ
cord-017917-7aeh6quc	114	56	upregulation	upregulation	NN
cord-017917-7aeh6quc	114	57	of	of	IN
cord-017917-7aeh6quc	114	58	Metalloproteinase-9	Metalloproteinase-9	NNP
cord-017917-7aeh6quc	114	59	by	by	IN
cord-017917-7aeh6quc	114	60	growth	growth	NN
cord-017917-7aeh6quc	114	61	factors	factor	NNS
cord-017917-7aeh6quc	114	62	and	and	CC
cord-017917-7aeh6quc	114	63	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	114	64	cytokines	cytokine	NNS
cord-017917-7aeh6quc	114	65	:	:	:
cord-017917-7aeh6quc	115	1	an	an	DT
cord-017917-7aeh6quc	115	2	absolute	absolute	JJ
cord-017917-7aeh6quc	115	3	requirement	requirement	NN
cord-017917-7aeh6quc	115	4	for	for	IN
cord-017917-7aeh6quc	115	5	transcription	transcription	NN
cord-017917-7aeh6quc	115	6	factor	factor	NN
cord-017917-7aeh6quc	115	7	NF	NF	NNP
cord-017917-7aeh6quc	115	8	-	-	HYPH
cord-017917-7aeh6quc	115	9	kB	kB	NNP
cord-017917-7aeh6quc	115	10	Nuclear	Nuclear	NNP
cord-017917-7aeh6quc	115	11	factor	factor	NN
cord-017917-7aeh6quc	115	12	kappaB	kappaB	NNP
cord-017917-7aeh6quc	115	13	activity	activity	NN
cord-017917-7aeh6quc	115	14	is	be	VBZ
cord-017917-7aeh6quc	115	15	essential	essential	JJ
cord-017917-7aeh6quc	115	16	for	for	IN
cord-017917-7aeh6quc	115	17	matrix	matrix	NN
cord-017917-7aeh6quc	115	18	metalloproteinase-1	metalloproteinase-1	NNP
cord-017917-7aeh6quc	115	19	and	and	CC
cord-017917-7aeh6quc	115	20	-3	-3	NNP
cord-017917-7aeh6quc	115	21	upregulation	upregulation	NN
cord-017917-7aeh6quc	115	22	in	in	IN
cord-017917-7aeh6quc	115	23	rabbit	rabbit	NN
cord-017917-7aeh6quc	115	24	dermal	dermal	JJ
cord-017917-7aeh6quc	115	25	fibroblasts	fibroblast	VBZ
cord-017917-7aeh6quc	115	26	Macrophage	Macrophage	NNP
cord-017917-7aeh6quc	115	27	metalloelastase	metalloelastase	NN
cord-017917-7aeh6quc	115	28	degrades	degrade	VBZ
cord-017917-7aeh6quc	115	29	matrix	matrix	NN
cord-017917-7aeh6quc	115	30	and	and	CC
cord-017917-7aeh6quc	115	31	myelin	myelin	NN
cord-017917-7aeh6quc	115	32	proteins	protein	NNS
cord-017917-7aeh6quc	115	33	and	and	CC
cord-017917-7aeh6quc	115	34	processes	process	VBZ
cord-017917-7aeh6quc	115	35	a	a	DT
cord-017917-7aeh6quc	115	36	tumour	tumour	NN
cord-017917-7aeh6quc	115	37	necrosis	necrosis	NN
cord-017917-7aeh6quc	115	38	factor	factor	NN
cord-017917-7aeh6quc	115	39	-	-	HYPH
cord-017917-7aeh6quc	115	40	alpha	alpha	NN
cord-017917-7aeh6quc	115	41	fusion	fusion	NN
cord-017917-7aeh6quc	115	42	protein	protein	NN
cord-017917-7aeh6quc	115	43	Matrix	Matrix	NNP
cord-017917-7aeh6quc	115	44	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	115	45	degrade	degrade	VBP
cord-017917-7aeh6quc	115	46	myelin	myelin	JJ
cord-017917-7aeh6quc	115	47	basic	basic	JJ
cord-017917-7aeh6quc	115	48	protein	protein	NN
cord-017917-7aeh6quc	115	49	Matrix	Matrix	NNP
cord-017917-7aeh6quc	115	50	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	115	51	expression	expression	NN
cord-017917-7aeh6quc	115	52	during	during	IN
cord-017917-7aeh6quc	115	53	experimental	experimental	JJ
cord-017917-7aeh6quc	115	54	autoimmune	autoimmune	JJ
cord-017917-7aeh6quc	115	55	encephalomyelitis	encephalomyelitis	NN
cord-017917-7aeh6quc	115	56	and	and	CC
cord-017917-7aeh6quc	115	57	effects	effect	NNS
cord-017917-7aeh6quc	115	58	of	of	IN
cord-017917-7aeh6quc	115	59	a	a	DT
cord-017917-7aeh6quc	115	60	combined	combine	VBN
cord-017917-7aeh6quc	115	61	matrix	matrix	NN
cord-017917-7aeh6quc	115	62	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	115	63	and	and	CC
cord-017917-7aeh6quc	115	64	tumour	tumour	NN
cord-017917-7aeh6quc	115	65	necrosis	necrosis	NN
cord-017917-7aeh6quc	115	66	factoralpha	factoralpha	NN
cord-017917-7aeh6quc	115	67	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	115	68	Plasminogen	Plasminogen	NNP
cord-017917-7aeh6quc	115	69	activators	activator	NNS
cord-017917-7aeh6quc	115	70	and	and	CC
cord-017917-7aeh6quc	115	71	matrix	matrix	NN
cord-017917-7aeh6quc	115	72	metalloproteases	metalloprotease	NNS
cord-017917-7aeh6quc	115	73	,	,	,
cord-017917-7aeh6quc	115	74	mediators	mediator	NNS
cord-017917-7aeh6quc	115	75	of	of	IN
cord-017917-7aeh6quc	115	76	extracellular	extracellular	JJ
cord-017917-7aeh6quc	115	77	proteolysis	proteolysis	NN
cord-017917-7aeh6quc	115	78	in	in	IN
cord-017917-7aeh6quc	115	79	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	115	80	demyelination	demyelination	NN
cord-017917-7aeh6quc	115	81	of	of	IN
cord-017917-7aeh6quc	115	82	the	the	DT
cord-017917-7aeh6quc	115	83	central	central	JJ
cord-017917-7aeh6quc	115	84	nervous	nervous	JJ
cord-017917-7aeh6quc	115	85	system	system	NN
cord-017917-7aeh6quc	115	86	Resistance	Resistance	NNP
cord-017917-7aeh6quc	115	87	of	of	IN
cord-017917-7aeh6quc	115	88	young	young	JJ
cord-017917-7aeh6quc	115	89	gelatinase	gelatinase	NN
cord-017917-7aeh6quc	115	90	B	b	NN
cord-017917-7aeh6quc	115	91	-	-	HYPH
cord-017917-7aeh6quc	115	92	deficient	deficient	JJ
cord-017917-7aeh6quc	115	93	mice	mouse	NNS
cord-017917-7aeh6quc	115	94	to	to	IN
cord-017917-7aeh6quc	115	95	experimental	experimental	JJ
cord-017917-7aeh6quc	115	96	autoimmune	autoimmune	JJ
cord-017917-7aeh6quc	115	97	encephalomyelitis	encephalomyelitis	NN
cord-017917-7aeh6quc	115	98	and	and	CC
cord-017917-7aeh6quc	115	99	necrotizing	necrotize	VBG
cord-017917-7aeh6quc	115	100	tail	tail	NN
cord-017917-7aeh6quc	115	101	lesions	lesion	NNS
cord-017917-7aeh6quc	115	102	Activation	activation	NN
cord-017917-7aeh6quc	115	103	of	of	IN
cord-017917-7aeh6quc	115	104	glial	glial	JJ
cord-017917-7aeh6quc	115	105	cells	cell	NNS
cord-017917-7aeh6quc	115	106	by	by	IN
cord-017917-7aeh6quc	115	107	human	human	JJ
cord-017917-7aeh6quc	115	108	coronavirus	coronavirus	NN
cord-017917-7aeh6quc	115	109	OC43	OC43	NNP
cord-017917-7aeh6quc	115	110	infection	infection	NN
cord-017917-7aeh6quc	115	111	Induction	induction	NN
cord-017917-7aeh6quc	115	112	of	of	IN
cord-017917-7aeh6quc	115	113	cell	cell	NN
cord-017917-7aeh6quc	115	114	migration	migration	NN
cord-017917-7aeh6quc	115	115	by	by	IN
cord-017917-7aeh6quc	115	116	matrix	matrix	NN
cord-017917-7aeh6quc	115	117	metalloprotease-2	metalloprotease-2	NNP
cord-017917-7aeh6quc	115	118	cleavage	cleavage	NN
cord-017917-7aeh6quc	115	119	of	of	IN
cord-017917-7aeh6quc	115	120	laminin-5	laminin-5	NNP
cord-017917-7aeh6quc	115	121	Reversal	reversal	NN
cord-017917-7aeh6quc	115	122	of	of	IN
cord-017917-7aeh6quc	115	123	experimental	experimental	JJ
cord-017917-7aeh6quc	115	124	autoimmune	autoimmune	JJ
cord-017917-7aeh6quc	115	125	encephalomyelitis	encephalomyelitis	NN
cord-017917-7aeh6quc	115	126	with	with	IN
cord-017917-7aeh6quc	115	127	a	a	DT
cord-017917-7aeh6quc	115	128	hydroxamate	hydroxamate	NN
cord-017917-7aeh6quc	115	129	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	115	130	of	of	IN
cord-017917-7aeh6quc	115	131	matrix	matrix	NN
cord-017917-7aeh6quc	115	132	metalloproteases	metalloprotease	NNS
cord-017917-7aeh6quc	115	133	Matrix	Matrix	NNP
cord-017917-7aeh6quc	115	134	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	115	135	in	in	IN
cord-017917-7aeh6quc	115	136	immunity	immunity	NN
cord-017917-7aeh6quc	116	1	Cytokines	cytokine	NNS
cord-017917-7aeh6quc	116	2	regulate	regulate	VBP
cord-017917-7aeh6quc	116	3	gelatinase	gelatinase	NN
cord-017917-7aeh6quc	116	4	A	a	NN
cord-017917-7aeh6quc	116	5	and	and	CC
cord-017917-7aeh6quc	116	6	B	b	NN
cord-017917-7aeh6quc	116	7	(	(	-LRB-
cord-017917-7aeh6quc	116	8	matrix	matrix	NN
cord-017917-7aeh6quc	116	9	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	116	10	2	2	CD
cord-017917-7aeh6quc	116	11	and	and	CC
cord-017917-7aeh6quc	116	12	9	9	CD
cord-017917-7aeh6quc	116	13	)	)	-RRB-
cord-017917-7aeh6quc	116	14	activity	activity	NN
cord-017917-7aeh6quc	116	15	in	in	IN
cord-017917-7aeh6quc	116	16	cultured	cultured	JJ
cord-017917-7aeh6quc	116	17	rat	rat	NN
cord-017917-7aeh6quc	116	18	astrocytes	astrocyte	NNS
cord-017917-7aeh6quc	117	1	The	the	DT
cord-017917-7aeh6quc	117	2	role	role	NN
cord-017917-7aeh6quc	117	3	of	of	IN
cord-017917-7aeh6quc	117	4	matrix	matrix	NN
cord-017917-7aeh6quc	117	5	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	117	6	in	in	IN
cord-017917-7aeh6quc	117	7	autoimmune	autoimmune	JJ
cord-017917-7aeh6quc	117	8	damage	damage	NN
cord-017917-7aeh6quc	117	9	to	to	IN
cord-017917-7aeh6quc	117	10	the	the	DT
cord-017917-7aeh6quc	117	11	central	central	JJ
cord-017917-7aeh6quc	117	12	and	and	CC
cord-017917-7aeh6quc	117	13	peripheral	peripheral	JJ
cord-017917-7aeh6quc	117	14	nervous	nervous	JJ
cord-017917-7aeh6quc	117	15	system	system	NN
cord-017917-7aeh6quc	117	16	Suppression	suppression	NN
cord-017917-7aeh6quc	117	17	of	of	IN
cord-017917-7aeh6quc	117	18	experimental	experimental	JJ
cord-017917-7aeh6quc	117	19	allergic	allergic	JJ
cord-017917-7aeh6quc	117	20	encephalomyelitis	encephalomyelitis	NN
cord-017917-7aeh6quc	117	21	in	in	IN
cord-017917-7aeh6quc	117	22	the	the	DT
cord-017917-7aeh6quc	117	23	Lewis	Lewis	NNP
cord-017917-7aeh6quc	117	24	rat	rat	NN
cord-017917-7aeh6quc	117	25	by	by	IN
cord-017917-7aeh6quc	117	26	the	the	DT
cord-017917-7aeh6quc	117	27	matrix	matrix	NN
cord-017917-7aeh6quc	117	28	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	117	29	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	117	30	Ro31	Ro31	NNP
cord-017917-7aeh6quc	117	31	-	-	HYPH
cord-017917-7aeh6quc	117	32	9790	9790	CD
cord-017917-7aeh6quc	117	33	Cytokine	cytokine	NN
cord-017917-7aeh6quc	117	34	inducible	inducible	JJ
cord-017917-7aeh6quc	117	35	matrix	matrix	NN
cord-017917-7aeh6quc	117	36	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	117	37	expression	expression	NN
cord-017917-7aeh6quc	117	38	in	in	IN
cord-017917-7aeh6quc	117	39	immortalized	immortalize	VBN
cord-017917-7aeh6quc	117	40	rat	rat	NN
cord-017917-7aeh6quc	117	41	chondrocytes	chondrocyte	NNS
cord-017917-7aeh6quc	117	42	is	be	VBZ
cord-017917-7aeh6quc	117	43	independent	independent	JJ
cord-017917-7aeh6quc	117	44	of	of	IN
cord-017917-7aeh6quc	117	45	nitric	nitric	JJ
cord-017917-7aeh6quc	117	46	oxide	oxide	NN
cord-017917-7aeh6quc	117	47	stimulation	stimulation	NN
cord-017917-7aeh6quc	117	48	Matrix	matrix	NN
cord-017917-7aeh6quc	117	49	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	117	50	in	in	IN
cord-017917-7aeh6quc	117	51	tumor	tumor	NN
cord-017917-7aeh6quc	117	52	invasion	invasion	NN
cord-017917-7aeh6quc	117	53	Structural	structural	JJ
cord-017917-7aeh6quc	117	54	biochemistry	biochemistry	NN
cord-017917-7aeh6quc	117	55	and	and	CC
cord-017917-7aeh6quc	117	56	activation	activation	NN
cord-017917-7aeh6quc	117	57	of	of	IN
cord-017917-7aeh6quc	117	58	matrix	matrix	NNP
cord-017917-7aeh6quc	117	59	metalloproteases	metalloproteases	NNP
cord-017917-7aeh6quc	117	60	Analysis	Analysis	NNP
cord-017917-7aeh6quc	117	61	of	of	IN
cord-017917-7aeh6quc	117	62	16	16	CD
cord-017917-7aeh6quc	117	63	different	different	JJ
cord-017917-7aeh6quc	117	64	matrix	matrix	NN
cord-017917-7aeh6quc	117	65	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	117	66	(	(	-LRB-
cord-017917-7aeh6quc	117	67	MMP-1	MMP-1	NNP
cord-017917-7aeh6quc	117	68	to	to	IN
cord-017917-7aeh6quc	117	69	MMP-20	MMP-20	NNP
cord-017917-7aeh6quc	117	70	)	)	-RRB-
cord-017917-7aeh6quc	117	71	in	in	IN
cord-017917-7aeh6quc	117	72	the	the	DT
cord-017917-7aeh6quc	117	73	synovial	synovial	JJ
cord-017917-7aeh6quc	117	74	membrane	membrane	NN
cord-017917-7aeh6quc	117	75	:	:	:
cord-017917-7aeh6quc	117	76	different	different	JJ
cord-017917-7aeh6quc	117	77	profiles	profile	NNS
cord-017917-7aeh6quc	117	78	in	in	IN
cord-017917-7aeh6quc	117	79	trauma	trauma	NN
cord-017917-7aeh6quc	117	80	and	and	CC
cord-017917-7aeh6quc	117	81	rheumatoid	rheumatoid	NN
cord-017917-7aeh6quc	117	82	arthritis	arthritis	NN
cord-017917-7aeh6quc	117	83	Differential	differential	NN
cord-017917-7aeh6quc	117	84	regulation	regulation	NN
cord-017917-7aeh6quc	117	85	of	of	IN
cord-017917-7aeh6quc	117	86	TIMP-1	TIMP-1	NNP
cord-017917-7aeh6quc	117	87	and	and	CC
cord-017917-7aeh6quc	117	88	TIMP-2	TIMP-2	NNP
cord-017917-7aeh6quc	117	89	mRNA	mRNA	NNP
cord-017917-7aeh6quc	117	90	expression	expression	NN
cord-017917-7aeh6quc	117	91	in	in	IN
cord-017917-7aeh6quc	117	92	normal	normal	JJ
cord-017917-7aeh6quc	117	93	and	and	CC
cord-017917-7aeh6quc	117	94	Ha	Ha	NNP
cord-017917-7aeh6quc	117	95	-	-	HYPH
cord-017917-7aeh6quc	117	96	ras	ras	NNP
cord-017917-7aeh6quc	117	97	-	-	HYPH
cord-017917-7aeh6quc	117	98	transformed	transform	VBN
cord-017917-7aeh6quc	117	99	murine	murine	JJ
cord-017917-7aeh6quc	117	100	fibroblasts	fibroblast	NNS
cord-017917-7aeh6quc	117	101	Expression	expression	NN
cord-017917-7aeh6quc	117	102	of	of	IN
cord-017917-7aeh6quc	117	103	matrix	matrix	NN
cord-017917-7aeh6quc	117	104	metalloproteinase-9	metalloproteinase-9	NNP
cord-017917-7aeh6quc	117	105	and	and	CC
cord-017917-7aeh6quc	117	106	its	-PRON-	PRP$
cord-017917-7aeh6quc	117	107	inhibitors	inhibitor	NNS
cord-017917-7aeh6quc	117	108	in	in	IN
cord-017917-7aeh6quc	117	109	mononuclear	mononuclear	JJ
cord-017917-7aeh6quc	117	110	blood	blood	NN
cord-017917-7aeh6quc	117	111	cells	cell	NNS
cord-017917-7aeh6quc	117	112	of	of	IN
cord-017917-7aeh6quc	117	113	patients	patient	NNS
cord-017917-7aeh6quc	117	114	with	with	IN
cord-017917-7aeh6quc	117	115	multiple	multiple	JJ
cord-017917-7aeh6quc	117	116	sclerosis	sclerosis	NN
cord-017917-7aeh6quc	117	117	Effective	effective	JJ
cord-017917-7aeh6quc	117	118	treatment	treatment	NN
cord-017917-7aeh6quc	117	119	of	of	IN
cord-017917-7aeh6quc	117	120	models	model	NNS
cord-017917-7aeh6quc	117	121	of	of	IN
cord-017917-7aeh6quc	117	122	multiple	multiple	JJ
cord-017917-7aeh6quc	117	123	sclerosis	sclerosis	NN
cord-017917-7aeh6quc	117	124	by	by	IN
cord-017917-7aeh6quc	117	125	matrix	matrix	NN
cord-017917-7aeh6quc	117	126	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	117	127	inhibitors	inhibitor	NNS
cord-017917-7aeh6quc	117	128	Gelatinase	Gelatinase	NNP
cord-017917-7aeh6quc	117	129	B	B	NNP
cord-017917-7aeh6quc	117	130	-	-	HYPH
cord-017917-7aeh6quc	117	131	deficient	deficient	JJ
cord-017917-7aeh6quc	117	132	mice	mouse	NNS
cord-017917-7aeh6quc	117	133	are	be	VBP
cord-017917-7aeh6quc	117	134	resistant	resistant	JJ
cord-017917-7aeh6quc	117	135	to	to	IN
cord-017917-7aeh6quc	117	136	experimental	experimental	JJ
cord-017917-7aeh6quc	117	137	bullous	bullous	JJ
cord-017917-7aeh6quc	117	138	pemphigoid	pemphigoid	NNP
cord-017917-7aeh6quc	117	139	Transcriptional	Transcriptional	NNP
cord-017917-7aeh6quc	117	140	suppression	suppression	NN
cord-017917-7aeh6quc	117	141	of	of	IN
cord-017917-7aeh6quc	117	142	matrix	matrix	NNP
cord-017917-7aeh6quc	117	143	metalloproteinase-9	metalloproteinase-9	NNP
cord-017917-7aeh6quc	117	144	gene	gene	NN
cord-017917-7aeh6quc	117	145	expression	expression	NN
cord-017917-7aeh6quc	117	146	by	by	IN
cord-017917-7aeh6quc	117	147	IFN	IFN	NNP
cord-017917-7aeh6quc	117	148	-	-	HYPH
cord-017917-7aeh6quc	117	149	gamma	gamma	NNP
cord-017917-7aeh6quc	117	150	and	and	CC
cord-017917-7aeh6quc	117	151	IFN	IFN	NNP
cord-017917-7aeh6quc	117	152	-	-	HYPH
cord-017917-7aeh6quc	117	153	beta	beta	NN
cord-017917-7aeh6quc	117	154	:	:	:
cord-017917-7aeh6quc	117	155	critical	critical	JJ
cord-017917-7aeh6quc	117	156	role	role	NN
cord-017917-7aeh6quc	117	157	of	of	IN
cord-017917-7aeh6quc	117	158	STAT	stat	NN
cord-017917-7aeh6quc	117	159	-	-	HYPH
cord-017917-7aeh6quc	117	160	lalpha	lalpha	NNS
cord-017917-7aeh6quc	117	161	Selective	selective	JJ
cord-017917-7aeh6quc	117	162	induction	induction	NN
cord-017917-7aeh6quc	117	163	of	of	IN
cord-017917-7aeh6quc	117	164	tissue	tissue	NN
cord-017917-7aeh6quc	117	165	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	117	166	of	of	IN
cord-017917-7aeh6quc	117	167	metalloproteinase-1	metalloproteinase-1	NNP
cord-017917-7aeh6quc	117	168	in	in	IN
cord-017917-7aeh6quc	117	169	bleomycin	bleomycin	NN
cord-017917-7aeh6quc	117	170	-	-	HYPH
cord-017917-7aeh6quc	117	171	induced	induce	VBN
cord-017917-7aeh6quc	117	172	pulmonary	pulmonary	JJ
cord-017917-7aeh6quc	117	173	fibrosis	fibrosis	NN
cord-017917-7aeh6quc	117	174	Matrix	Matrix	NNP
cord-017917-7aeh6quc	117	175	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	117	176	in	in	IN
cord-017917-7aeh6quc	117	177	the	the	DT
cord-017917-7aeh6quc	117	178	normal	normal	JJ
cord-017917-7aeh6quc	117	179	human	human	JJ
cord-017917-7aeh6quc	117	180	central	central	JJ
cord-017917-7aeh6quc	117	181	nervous	nervous	JJ
cord-017917-7aeh6quc	117	182	system	system	NN
cord-017917-7aeh6quc	117	183	,	,	,
cord-017917-7aeh6quc	117	184	microglial	microglial	JJ
cord-017917-7aeh6quc	117	185	nodules	nodule	NNS
cord-017917-7aeh6quc	117	186	,	,	,
cord-017917-7aeh6quc	117	187	and	and	CC
cord-017917-7aeh6quc	117	188	multiple	multiple	JJ
cord-017917-7aeh6quc	117	189	sclerosis	sclerosis	NN
cord-017917-7aeh6quc	117	190	lesions	lesion	NNS
cord-017917-7aeh6quc	117	191	MHV	MHV	NNP
cord-017917-7aeh6quc	117	192	infection	infection	NN
cord-017917-7aeh6quc	117	193	of	of	IN
cord-017917-7aeh6quc	117	194	the	the	DT
cord-017917-7aeh6quc	117	195	CNS	CNS	NNP
cord-017917-7aeh6quc	117	196	:	:	:
cord-017917-7aeh6quc	117	197	mechanisms	mechanism	NNS
cord-017917-7aeh6quc	117	198	of	of	IN
cord-017917-7aeh6quc	117	199	immune	immune	NN
cord-017917-7aeh6quc	117	200	-	-	HYPH
cord-017917-7aeh6quc	117	201	mediated	mediate	VBN
cord-017917-7aeh6quc	117	202	control	control	NN
cord-017917-7aeh6quc	117	203	Matrix	matrix	NN
cord-017917-7aeh6quc	117	204	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	117	205	Gelatinase	Gelatinase	NNP
cord-017917-7aeh6quc	117	206	B	B	NNP
cord-017917-7aeh6quc	117	207	functions	function	NNS
cord-017917-7aeh6quc	117	208	as	as	IN
cord-017917-7aeh6quc	117	209	regulator	regulator	NN
cord-017917-7aeh6quc	117	210	and	and	CC
cord-017917-7aeh6quc	117	211	effector	effector	VB
cord-017917-7aeh6quc	117	212	in	in	IN
cord-017917-7aeh6quc	117	213	leukocyte	leukocyte	NN
cord-017917-7aeh6quc	117	214	biology	biology	NN
cord-017917-7aeh6quc	117	215	Gelatinase	Gelatinase	NNP
cord-017917-7aeh6quc	117	216	B	B	NNP
cord-017917-7aeh6quc	117	217	:	:	:
cord-017917-7aeh6quc	117	218	a	a	DT
cord-017917-7aeh6quc	117	219	tuner	tuner	NN
cord-017917-7aeh6quc	117	220	and	and	CC
cord-017917-7aeh6quc	117	221	amplifier	amplifier	NN
cord-017917-7aeh6quc	117	222	of	of	IN
cord-017917-7aeh6quc	117	223	immune	immune	JJ
cord-017917-7aeh6quc	117	224	functions	function	NNS
cord-017917-7aeh6quc	117	225	Multiple	multiple	JJ
cord-017917-7aeh6quc	117	226	sclerosis	sclerosis	NN
cord-017917-7aeh6quc	117	227	:	:	:
cord-017917-7aeh6quc	117	228	pro	pro	JJ
cord-017917-7aeh6quc	117	229	-	-	JJ
cord-017917-7aeh6quc	117	230	and	and	CC
cord-017917-7aeh6quc	117	231	anti	anti	JJ
cord-017917-7aeh6quc	117	232	-	-	JJ
cord-017917-7aeh6quc	117	233	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	117	234	cytokines	cytokine	NNS
cord-017917-7aeh6quc	117	235	and	and	CC
cord-017917-7aeh6quc	117	236	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	117	237	are	be	VBP
cord-017917-7aeh6quc	117	238	affected	affect	VBN
cord-017917-7aeh6quc	117	239	differentially	differentially	RB
cord-017917-7aeh6quc	117	240	by	by	IN
cord-017917-7aeh6quc	117	241	treatment	treatment	NN
cord-017917-7aeh6quc	117	242	with	with	IN
cord-017917-7aeh6quc	117	243	IFN	IFN	NNP
cord-017917-7aeh6quc	117	244	-	-	HYPH
cord-017917-7aeh6quc	117	245	beta	beta	NNP
cord-017917-7aeh6quc	117	246	Differential	differential	JJ
cord-017917-7aeh6quc	117	247	expression	expression	NN
cord-017917-7aeh6quc	117	248	of	of	IN
cord-017917-7aeh6quc	117	249	matrix	matrix	NN
cord-017917-7aeh6quc	117	250	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	117	251	and	and	CC
cord-017917-7aeh6quc	117	252	tissue	tissue	NN
cord-017917-7aeh6quc	117	253	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	117	254	of	of	IN
cord-017917-7aeh6quc	117	255	matrix	matrix	NN
cord-017917-7aeh6quc	117	256	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	117	257	genes	gene	NNS
cord-017917-7aeh6quc	117	258	in	in	IN
cord-017917-7aeh6quc	117	259	the	the	DT
cord-017917-7aeh6quc	117	260	mouse	mouse	NN
cord-017917-7aeh6quc	117	261	central	central	JJ
cord-017917-7aeh6quc	117	262	nervous	nervous	JJ
cord-017917-7aeh6quc	117	263	system	system	NN
cord-017917-7aeh6quc	117	264	in	in	IN
cord-017917-7aeh6quc	117	265	normal	normal	JJ
cord-017917-7aeh6quc	117	266	and	and	CC
cord-017917-7aeh6quc	117	267	inflammatory	inflammatory	JJ
cord-017917-7aeh6quc	117	268	states	state	NNS
cord-017917-7aeh6quc	118	1	Leukocyte	Leukocyte	NNP
cord-017917-7aeh6quc	118	2	gelatinase	gelatinase	NN
cord-017917-7aeh6quc	118	3	B	b	NN
cord-017917-7aeh6quc	118	4	cleavage	cleavage	NN
cord-017917-7aeh6quc	118	5	releases	release	NNS
cord-017917-7aeh6quc	118	6	encephalitogens	encephalitogen	NNS
cord-017917-7aeh6quc	118	7	from	from	IN
cord-017917-7aeh6quc	118	8	human	human	JJ
cord-017917-7aeh6quc	118	9	myelin	myelin	JJ
cord-017917-7aeh6quc	118	10	basic	basic	JJ
cord-017917-7aeh6quc	118	11	protein	protein	NN
cord-017917-7aeh6quc	118	12	cytokine	cytokine	NN
cord-017917-7aeh6quc	118	13	regulation	regulation	NN
cord-017917-7aeh6quc	118	14	of	of	IN
cord-017917-7aeh6quc	118	15	Matrix	Matrix	NNP
cord-017917-7aeh6quc	118	16	Metalloproteinase	Metalloproteinase	NNP
cord-017917-7aeh6quc	118	17	activity	activity	NN
cord-017917-7aeh6quc	118	18	and	and	CC
cord-017917-7aeh6quc	118	19	its	-PRON-	PRP$
cord-017917-7aeh6quc	118	20	regulatory	regulatory	JJ
cord-017917-7aeh6quc	118	21	dysfunction	dysfunction	NN
cord-017917-7aeh6quc	118	22	in	in	IN
cord-017917-7aeh6quc	118	23	disease	disease	NN
cord-017917-7aeh6quc	118	24	Coordinate	coordinate	VB
cord-017917-7aeh6quc	118	25	expression	expression	NN
cord-017917-7aeh6quc	118	26	of	of	IN
cord-017917-7aeh6quc	118	27	matrix	matrix	NN
cord-017917-7aeh6quc	118	28	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	118	29	family	family	NN
cord-017917-7aeh6quc	118	30	members	member	NNS
cord-017917-7aeh6quc	118	31	in	in	IN
cord-017917-7aeh6quc	118	32	the	the	DT
cord-017917-7aeh6quc	118	33	uterus	uterus	NN
cord-017917-7aeh6quc	118	34	of	of	IN
cord-017917-7aeh6quc	118	35	normal	normal	JJ
cord-017917-7aeh6quc	118	36	,	,	,
cord-017917-7aeh6quc	118	37	matrilysin	matrilysin	NN
cord-017917-7aeh6quc	118	38	-	-	HYPH
cord-017917-7aeh6quc	118	39	deficient	deficient	JJ
cord-017917-7aeh6quc	118	40	,	,	,
cord-017917-7aeh6quc	118	41	and	and	CC
cord-017917-7aeh6quc	118	42	stromelysin	stromelysin	NNP
cord-017917-7aeh6quc	118	43	-	-	HYPH
cord-017917-7aeh6quc	118	44	l	l	NN
cord-017917-7aeh6quc	118	45	-	-	HYPH
cord-017917-7aeh6quc	118	46	deficient	deficient	JJ
cord-017917-7aeh6quc	118	47	mice	mouse	NNS
cord-017917-7aeh6quc	118	48	Cell	cell	NN
cord-017917-7aeh6quc	118	49	surface	surface	NN
cord-017917-7aeh6quc	118	50	binding	binding	NN
cord-017917-7aeh6quc	118	51	and	and	CC
cord-017917-7aeh6quc	118	52	activation	activation	NN
cord-017917-7aeh6quc	118	53	of	of	IN
cord-017917-7aeh6quc	118	54	gelatinase	gelatinase	NN
cord-017917-7aeh6quc	118	55	A	A	NNP
cord-017917-7aeh6quc	118	56	induced	induce	VBN
cord-017917-7aeh6quc	118	57	by	by	IN
cord-017917-7aeh6quc	118	58	expression	expression	NN
cord-017917-7aeh6quc	118	59	of	of	IN
cord-017917-7aeh6quc	118	60	membrane	membrane	NN
cord-017917-7aeh6quc	118	61	-	-	HYPH
cord-017917-7aeh6quc	118	62	type	type	NN
cord-017917-7aeh6quc	118	63	-	-	HYPH
cord-017917-7aeh6quc	118	64	l	l	NN
cord-017917-7aeh6quc	118	65	-	-	HYPH
cord-017917-7aeh6quc	118	66	matrix	matrix	NN
cord-017917-7aeh6quc	118	67	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	118	68	(	(	-LRB-
cord-017917-7aeh6quc	118	69	MT1-MMP	MT1-MMP	NNP
cord-017917-7aeh6quc	118	70	)	)	-RRB-
cord-017917-7aeh6quc	118	71	Mouse	Mouse	NNP
cord-017917-7aeh6quc	118	72	hepatitis	hepatitis	NN
cord-017917-7aeh6quc	118	73	virus	virus	NN
cord-017917-7aeh6quc	118	74	Mechanism	mechanism	NN
cord-017917-7aeh6quc	118	75	of	of	IN
cord-017917-7aeh6quc	118	76	cell	cell	NN
cord-017917-7aeh6quc	118	77	surface	surface	NN
cord-017917-7aeh6quc	118	78	activation	activation	NN
cord-017917-7aeh6quc	118	79	of	of	IN
cord-017917-7aeh6quc	118	80	72-kDa	72-kda	CD
cord-017917-7aeh6quc	118	81	type	type	NN
cord-017917-7aeh6quc	118	82	IV	IV	NNP
cord-017917-7aeh6quc	118	83	collagenase	collagenase	NNP
cord-017917-7aeh6quc	118	84	.	.	.
cord-017917-7aeh6quc	119	1	Isolation	isolation	NN
cord-017917-7aeh6quc	119	2	of	of	IN
cord-017917-7aeh6quc	119	3	the	the	DT
cord-017917-7aeh6quc	119	4	activated	activate	VBN
cord-017917-7aeh6quc	119	5	form	form	NN
cord-017917-7aeh6quc	119	6	of	of	IN
cord-017917-7aeh6quc	119	7	the	the	DT
cord-017917-7aeh6quc	119	8	membrane	membrane	NN
cord-017917-7aeh6quc	119	9	metalloprotease	metalloprotease	NNP
cord-017917-7aeh6quc	120	1	Interferon	interferon	NN
cord-017917-7aeh6quc	120	2	beta	beta	NN
cord-017917-7aeh6quc	120	3	-	-	HYPH
cord-017917-7aeh6quc	120	4	lb	lb	NN
cord-017917-7aeh6quc	120	5	decreases	decrease	VBZ
cord-017917-7aeh6quc	120	6	the	the	DT
cord-017917-7aeh6quc	120	7	migration	migration	NN
cord-017917-7aeh6quc	120	8	of	of	IN
cord-017917-7aeh6quc	120	9	T	t	NN
cord-017917-7aeh6quc	120	10	lymphocytes	lymphocyte	NNS
cord-017917-7aeh6quc	120	11	in	in	IN
cord-017917-7aeh6quc	120	12	vitro	vitro	FW
cord-017917-7aeh6quc	120	13	:	:	:
cord-017917-7aeh6quc	120	14	effects	effect	NNS
cord-017917-7aeh6quc	120	15	on	on	IN
cord-017917-7aeh6quc	120	16	matrix	matrix	NN
cord-017917-7aeh6quc	120	17	metalloproteinase-9	metalloproteinase-9	NNP
cord-017917-7aeh6quc	120	18	Changes	change	NNS
cord-017917-7aeh6quc	120	19	of	of	IN
cord-017917-7aeh6quc	120	20	serum	serum	NN
cord-017917-7aeh6quc	120	21	sICAM-1	sICAM-1	NNP
cord-017917-7aeh6quc	120	22	and	and	CC
cord-017917-7aeh6quc	120	23	MMP-9	MMP-9	NNP
cord-017917-7aeh6quc	120	24	induced	induce	VBN
cord-017917-7aeh6quc	120	25	by	by	IN
cord-017917-7aeh6quc	120	26	rIFNbeta	rifnbeta	NN
cord-017917-7aeh6quc	120	27	-	-	HYPH
cord-017917-7aeh6quc	120	28	lb	lb	NN
cord-017917-7aeh6quc	120	29	treatment	treatment	NN
cord-017917-7aeh6quc	120	30	in	in	IN
cord-017917-7aeh6quc	120	31	relapsingremitting	relapsingremitte	VBG
cord-017917-7aeh6quc	120	32	MS	MS	NNP
cord-017917-7aeh6quc	120	33	Neutrophil	Neutrophil	NNP
cord-017917-7aeh6quc	120	34	gelatinase	gelatinase	NN
cord-017917-7aeh6quc	120	35	B	b	NN
cord-017917-7aeh6quc	121	1	potentiates	potentiate	VBZ
cord-017917-7aeh6quc	121	2	interleukin-8	interleukin-8	NNP
cord-017917-7aeh6quc	121	3	tenfold	tenfold	RB
cord-017917-7aeh6quc	121	4	by	by	IN
cord-017917-7aeh6quc	121	5	aminoterminal	aminoterminal	JJ
cord-017917-7aeh6quc	121	6	processing	processing	NN
cord-017917-7aeh6quc	121	7	,	,	,
cord-017917-7aeh6quc	121	8	whereas	whereas	IN
cord-017917-7aeh6quc	121	9	it	-PRON-	PRP
cord-017917-7aeh6quc	121	10	degrades	degrade	VBZ
cord-017917-7aeh6quc	121	11	CTAP	CTAP	NNP
cord-017917-7aeh6quc	121	12	-	-	HYPH
cord-017917-7aeh6quc	121	13	III	III	NNP
cord-017917-7aeh6quc	121	14	,	,	,
cord-017917-7aeh6quc	121	15	PF-4	PF-4	NNP
cord-017917-7aeh6quc	121	16	,	,	,
cord-017917-7aeh6quc	121	17	and	and	CC
cord-017917-7aeh6quc	121	18	GRO	gro	NN
cord-017917-7aeh6quc	121	19	-	-	HYPH
cord-017917-7aeh6quc	121	20	alpha	alpha	NN
cord-017917-7aeh6quc	121	21	and	and	CC
cord-017917-7aeh6quc	121	22	leaves	leave	VBZ
cord-017917-7aeh6quc	121	23	RANTES	RANTES	NNPS
cord-017917-7aeh6quc	121	24	and	and	CC
cord-017917-7aeh6quc	121	25	MCP-2	mcp-2	JJ
cord-017917-7aeh6quc	121	26	intact	intact	JJ
cord-017917-7aeh6quc	121	27	Gelatinase	Gelatinase	NNP
cord-017917-7aeh6quc	121	28	contributes	contribute	VBZ
cord-017917-7aeh6quc	121	29	to	to	IN
cord-017917-7aeh6quc	121	30	the	the	DT
cord-017917-7aeh6quc	121	31	degradation	degradation	NN
cord-017917-7aeh6quc	121	32	of	of	IN
cord-017917-7aeh6quc	121	33	glomerular	glomerular	JJ
cord-017917-7aeh6quc	121	34	basement	basement	NN
cord-017917-7aeh6quc	121	35	membrane	membrane	NN
cord-017917-7aeh6quc	121	36	collagen	collagen	NN
cord-017917-7aeh6quc	121	37	by	by	IN
cord-017917-7aeh6quc	121	38	human	human	JJ
cord-017917-7aeh6quc	121	39	neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	121	40	Matrix	Matrix	NNP
cord-017917-7aeh6quc	121	41	metalloproteinases	metalloproteinase	NNS
cord-017917-7aeh6quc	121	42	and	and	CC
cord-017917-7aeh6quc	121	43	diseases	disease	NNS
cord-017917-7aeh6quc	121	44	of	of	IN
cord-017917-7aeh6quc	121	45	the	the	DT
cord-017917-7aeh6quc	121	46	CNS	CNS	NNP
cord-017917-7aeh6quc	121	47	Matrix	Matrix	NNP
cord-017917-7aeh6quc	121	48	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	121	49	expression	expression	NN
cord-017917-7aeh6quc	121	50	correlates	correlate	VBZ
cord-017917-7aeh6quc	121	51	with	with	IN
cord-017917-7aeh6quc	121	52	virulence	virulence	NN
cord-017917-7aeh6quc	121	53	following	follow	VBG
cord-017917-7aeh6quc	122	1	neurotropic	neurotropic	NNP
cord-017917-7aeh6quc	122	2	mouse	mouse	NNP
cord-017917-7aeh6quc	122	3	hepatitis	hepatitis	NNP
cord-017917-7aeh6quc	122	4	virus	virus	NN
cord-017917-7aeh6quc	122	5	infection	infection	NN
cord-017917-7aeh6quc	122	6	Neutrophils	neutrophil	NNS
cord-017917-7aeh6quc	122	7	modulate	modulate	VBP
cord-017917-7aeh6quc	122	8	inflammation	inflammation	NN
cord-017917-7aeh6quc	122	9	during	during	IN
cord-017917-7aeh6quc	122	10	viral	viral	JJ
cord-017917-7aeh6quc	122	11	induced	induce	VBN
cord-017917-7aeh6quc	122	12	encephalitis	encephalitis	NN
cord-017917-7aeh6quc	122	13	Regulation	regulation	NN
cord-017917-7aeh6quc	122	14	of	of	IN
cord-017917-7aeh6quc	122	15	matrix	matrix	NN
cord-017917-7aeh6quc	122	16	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	122	17	(	(	-LRB-
cord-017917-7aeh6quc	122	18	MMP	MMP	NNP
cord-017917-7aeh6quc	122	19	)	)	-RRB-
cord-017917-7aeh6quc	122	20	and	and	CC
cord-017917-7aeh6quc	122	21	tissue	tissue	NN
cord-017917-7aeh6quc	122	22	inhibitor	inhibitor	NN
cord-017917-7aeh6quc	122	23	of	of	IN
cord-017917-7aeh6quc	122	24	matrix	matrix	NN
cord-017917-7aeh6quc	122	25	metalloproteinase	metalloproteinase	NN
cord-017917-7aeh6quc	122	26	(	(	-LRB-
cord-017917-7aeh6quc	122	27	TIMP	TIMP	NNP
cord-017917-7aeh6quc	122	28	)	)	-RRB-
cord-017917-7aeh6quc	122	29	genes	gene	NNS
cord-017917-7aeh6quc	122	30	during	during	IN
cord-017917-7aeh6quc	122	31	JHMV	JHMV	NNP
cord-017917-7aeh6quc	122	32	infection	infection	NN
cord-017917-7aeh6quc	122	33	of	of	IN
cord-017917-7aeh6quc	122	34	the	the	DT
cord-017917-7aeh6quc	122	35	central	central	JJ
cord-017917-7aeh6quc	122	36	nervous	nervous	JJ
cord-017917-7aeh6quc	122	37	system	system	NN