id	sid	tid	token	lemma	pos
cord-022594-fx044gcd	1	1	key	key	JJ
cord-022594-fx044gcd	1	2	:	:	:
cord-022594-fx044gcd	1	3	cord-022594-fx044gcd	cord-022594-fx044gcd	CD
cord-022594-fx044gcd	1	4	authors	author	NNS
cord-022594-fx044gcd	1	5	:	:	:
cord-022594-fx044gcd	1	6	Pirko	Pirko	NNP
cord-022594-fx044gcd	1	7	,	,	,
cord-022594-fx044gcd	1	8	Istvan	Istvan	NNP
cord-022594-fx044gcd	1	9	;	;	:
cord-022594-fx044gcd	1	10	Noseworthy	Noseworthy	NNP
cord-022594-fx044gcd	1	11	,	,	,
cord-022594-fx044gcd	2	1	John	John	NNP
cord-022594-fx044gcd	2	2	H.	H.	NNP
cord-022594-fx044gcd	2	3	title	title	NN
cord-022594-fx044gcd	2	4	:	:	:
cord-022594-fx044gcd	3	1	Demyelinating	demyelinate	VBG
cord-022594-fx044gcd	3	2	Disorders	disorder	NNS
cord-022594-fx044gcd	3	3	of	of	IN
cord-022594-fx044gcd	3	4	the	the	DT
cord-022594-fx044gcd	3	5	Central	Central	NNP
cord-022594-fx044gcd	3	6	Nervous	Nervous	NNP
cord-022594-fx044gcd	3	7	System	System	NNP
cord-022594-fx044gcd	3	8	date	date	NN
cord-022594-fx044gcd	3	9	:	:	:
cord-022594-fx044gcd	3	10	2009	2009	CD
cord-022594-fx044gcd	3	11	-	-	SYM
cord-022594-fx044gcd	3	12	05	05	CD
cord-022594-fx044gcd	3	13	-	-	SYM
cord-022594-fx044gcd	3	14	18	18	CD
cord-022594-fx044gcd	3	15	journal	journal	NN
cord-022594-fx044gcd	3	16	:	:	:
cord-022594-fx044gcd	4	1	Textbook	textbook	NN
cord-022594-fx044gcd	4	2	of	of	IN
cord-022594-fx044gcd	4	3	Clinical	Clinical	NNP
cord-022594-fx044gcd	4	4	Neurology	Neurology	NNP
cord-022594-fx044gcd	4	5	DOI	DOI	NNP
cord-022594-fx044gcd	4	6	:	:	:
cord-022594-fx044gcd	5	1	10.1016	10.1016	CD
cord-022594-fx044gcd	5	2	/	/	SYM
cord-022594-fx044gcd	5	3	b978	b978	NNP
cord-022594-fx044gcd	5	4	-	-	HYPH
cord-022594-fx044gcd	5	5	141603618	141603618	CD
cord-022594-fx044gcd	5	6	-	-	HYPH
cord-022594-fx044gcd	5	7	0.10048	0.10048	CD
cord-022594-fx044gcd	5	8	-	-	SYM
cord-022594-fx044gcd	5	9	7	7	CD
cord-022594-fx044gcd	5	10	sha	sha	NN
cord-022594-fx044gcd	5	11	:	:	:
cord-022594-fx044gcd	5	12	fb064d9389faa4ca474ec0b4490857981484e522	fb064d9389faa4ca474ec0b4490857981484e522	NNP
cord-022594-fx044gcd	5	13	doc_id	doc_id	CD
cord-022594-fx044gcd	5	14	:	:	:
cord-022594-fx044gcd	6	1	22594	22594	CD
cord-022594-fx044gcd	6	2	cord_uid	cord_uid	NNS
cord-022594-fx044gcd	6	3	:	:	:
cord-022594-fx044gcd	6	4	fx044gcd	fx044gcd	NNP
cord-022594-fx044gcd	6	5	nan	nan	NNP
cord-022594-fx044gcd	6	6	Demyelinating	Demyelinating	NNP
cord-022594-fx044gcd	6	7	Disorders	disorder	NNS
cord-022594-fx044gcd	6	8	of	of	IN
cord-022594-fx044gcd	6	9	the	the	DT
cord-022594-fx044gcd	6	10	Central	Central	NNP
cord-022594-fx044gcd	6	11	Nervous	Nervous	NNP
cord-022594-fx044gcd	6	12	System	System	NNP
cord-022594-fx044gcd	6	13	Istvan	Istvan	NNP
cord-022594-fx044gcd	6	14	Pirko	Pirko	NNP
cord-022594-fx044gcd	6	15	and	and	CC
cord-022594-fx044gcd	6	16	John	John	NNP
cord-022594-fx044gcd	6	17	H.	H.	NNP
cord-022594-fx044gcd	6	18	Noseworthy	Noseworthy	NNP
cord-022594-fx044gcd	6	19	Multiple	multiple	JJ
cord-022594-fx044gcd	6	20	sclerosis	sclerosis	NN
cord-022594-fx044gcd	6	21	(	(	-LRB-
cord-022594-fx044gcd	6	22	MS	MS	NNP
cord-022594-fx044gcd	6	23	)	)	-RRB-
cord-022594-fx044gcd	6	24	is	be	VBZ
cord-022594-fx044gcd	6	25	now	now	RB
cord-022594-fx044gcd	6	26	known	know	VBN
cord-022594-fx044gcd	6	27	to	to	TO
cord-022594-fx044gcd	6	28	be	be	VB
cord-022594-fx044gcd	6	29	a	a	DT
cord-022594-fx044gcd	6	30	common	common	JJ
cord-022594-fx044gcd	6	31	malady	malady	NN
cord-022594-fx044gcd	6	32	even	even	RB
cord-022594-fx044gcd	6	33	though	though	IN
cord-022594-fx044gcd	6	34	it	-PRON-	PRP
cord-022594-fx044gcd	6	35	was	be	VBD
cord-022594-fx044gcd	6	36	first	first	RB
cord-022594-fx044gcd	6	37	recognized	recognize	VBN
cord-022594-fx044gcd	6	38	as	as	IN
cord-022594-fx044gcd	6	39	a	a	DT
cord-022594-fx044gcd	6	40	distinct	distinct	JJ
cord-022594-fx044gcd	6	41	clinicopathological	clinicopathological	JJ
cord-022594-fx044gcd	6	42	entity	entity	NN
cord-022594-fx044gcd	6	43	less	less	JJR
cord-022594-fx044gcd	6	44	than	than	IN
cord-022594-fx044gcd	6	45	150	150	CD
cord-022594-fx044gcd	6	46	years	year	NNS
cord-022594-fx044gcd	6	47	ago	ago	RB
cord-022594-fx044gcd	6	48	.	.	.
cord-022594-fx044gcd	7	1	1	1	LS
cord-022594-fx044gcd	8	1	The	the	DT
cord-022594-fx044gcd	8	2	lack	lack	NN
cord-022594-fx044gcd	8	3	of	of	IN
cord-022594-fx044gcd	8	4	clear	clear	JJ
cord-022594-fx044gcd	8	5	medical	medical	JJ
cord-022594-fx044gcd	8	6	reports	report	NNS
cord-022594-fx044gcd	8	7	before	before	IN
cord-022594-fx044gcd	8	8	the	the	DT
cord-022594-fx044gcd	8	9	early	early	JJ
cord-022594-fx044gcd	8	10	1800s	1800	NNS
cord-022594-fx044gcd	8	11	is	be	VBZ
cord-022594-fx044gcd	8	12	sometimes	sometimes	RB
cord-022594-fx044gcd	8	13	interpreted	interpret	VBN
cord-022594-fx044gcd	8	14	as	as	IN
cord-022594-fx044gcd	8	15	evidence	evidence	NN
cord-022594-fx044gcd	8	16	that	that	IN
cord-022594-fx044gcd	8	17	MS	MS	NNP
cord-022594-fx044gcd	8	18	is	be	VBZ
cord-022594-fx044gcd	8	19	a	a	DT
cord-022594-fx044gcd	8	20	relatively	relatively	RB
cord-022594-fx044gcd	8	21	new	new	JJ
cord-022594-fx044gcd	8	22	disease	disease	NN
cord-022594-fx044gcd	8	23	.	.	.
cord-022594-fx044gcd	9	1	However	however	RB
cord-022594-fx044gcd	9	2	,	,	,
cord-022594-fx044gcd	9	3	it	-PRON-	PRP
cord-022594-fx044gcd	9	4	is	be	VBZ
cord-022594-fx044gcd	9	5	more	more	RBR
cord-022594-fx044gcd	9	6	likely	likely	JJ
cord-022594-fx044gcd	9	7	that	that	IN
cord-022594-fx044gcd	9	8	the	the	DT
cord-022594-fx044gcd	9	9	evolution	evolution	NN
cord-022594-fx044gcd	9	10	of	of	IN
cord-022594-fx044gcd	9	11	medicine	medicine	NN
cord-022594-fx044gcd	9	12	into	into	IN
cord-022594-fx044gcd	9	13	science	science	NN
cord-022594-fx044gcd	9	14	led	lead	VBD
cord-022594-fx044gcd	9	15	to	to	IN
cord-022594-fx044gcd	9	16	more	more	RBR
cord-022594-fx044gcd	9	17	precise	precise	JJ
cord-022594-fx044gcd	9	18	observation	observation	NN
cord-022594-fx044gcd	9	19	and	and	CC
cord-022594-fx044gcd	9	20	description	description	NN
cord-022594-fx044gcd	9	21	of	of	IN
cord-022594-fx044gcd	9	22	human	human	JJ
cord-022594-fx044gcd	9	23	diseases	disease	NNS
cord-022594-fx044gcd	9	24	,	,	,
cord-022594-fx044gcd	9	25	including	include	VBG
cord-022594-fx044gcd	9	26	MS	MS	NNP
cord-022594-fx044gcd	9	27	.	.	.
cord-022594-fx044gcd	10	1	Saint	Saint	NNP
cord-022594-fx044gcd	10	2	Lidwina	Lidwina	NNP
cord-022594-fx044gcd	10	3	of	of	IN
cord-022594-fx044gcd	10	4	Schiedam	Schiedam	NNP
cord-022594-fx044gcd	10	5	(	(	-LRB-
cord-022594-fx044gcd	10	6	1380	1380	CD
cord-022594-fx044gcd	10	7	-	-	SYM
cord-022594-fx044gcd	10	8	1433	1433	CD
cord-022594-fx044gcd	10	9	)	)	-RRB-
cord-022594-fx044gcd	10	10	developed	develop	VBD
cord-022594-fx044gcd	10	11	a	a	DT
cord-022594-fx044gcd	10	12	relapsing	relapse	VBG
cord-022594-fx044gcd	10	13	neurological	neurological	JJ
cord-022594-fx044gcd	10	14	disorder	disorder	NN
cord-022594-fx044gcd	10	15	at	at	IN
cord-022594-fx044gcd	10	16	the	the	DT
cord-022594-fx044gcd	10	17	age	age	NN
cord-022594-fx044gcd	10	18	of	of	IN
cord-022594-fx044gcd	10	19	18	18	CD
cord-022594-fx044gcd	10	20	and	and	CC
cord-022594-fx044gcd	10	21	may	may	MD
cord-022594-fx044gcd	10	22	be	be	VB
cord-022594-fx044gcd	10	23	the	the	DT
cord-022594-fx044gcd	10	24	first	first	JJ
cord-022594-fx044gcd	10	25	case	case	NN
cord-022594-fx044gcd	10	26	of	of	IN
cord-022594-fx044gcd	10	27	clinically	clinically	RB
cord-022594-fx044gcd	10	28	described	describe	VBN
cord-022594-fx044gcd	10	29	MS	MS	NNP
cord-022594-fx044gcd	10	30	.	.	.
cord-022594-fx044gcd	11	1	2	2	LS
cord-022594-fx044gcd	11	2	Ollivier	Ollivier	NNP
cord-022594-fx044gcd	11	3	was	be	VBD
cord-022594-fx044gcd	11	4	the	the	DT
cord-022594-fx044gcd	11	5	first	first	JJ
cord-022594-fx044gcd	11	6	to	to	TO
cord-022594-fx044gcd	11	7	report	report	VB
cord-022594-fx044gcd	11	8	a	a	DT
cord-022594-fx044gcd	11	9	clinical	clinical	JJ
cord-022594-fx044gcd	11	10	case	case	NN
cord-022594-fx044gcd	11	11	in	in	IN
cord-022594-fx044gcd	11	12	the	the	DT
cord-022594-fx044gcd	11	13	medical	medical	JJ
cord-022594-fx044gcd	11	14	literature	literature	NN
cord-022594-fx044gcd	11	15	in	in	IN
cord-022594-fx044gcd	11	16	1824	1824	CD
cord-022594-fx044gcd	11	17	.	.	.
cord-022594-fx044gcd	12	1	1	1	LS
cord-022594-fx044gcd	13	1	Shortly	shortly	RB
cord-022594-fx044gcd	13	2	thereafter	thereafter	RB
cord-022594-fx044gcd	13	3	,	,	,
cord-022594-fx044gcd	13	4	Carswell	Carswell	NNP
cord-022594-fx044gcd	13	5	illustrated	illustrate	VBD
cord-022594-fx044gcd	13	6	a	a	DT
cord-022594-fx044gcd	13	7	case	case	NN
cord-022594-fx044gcd	13	8	of	of	IN
cord-022594-fx044gcd	13	9	what	what	WP
cord-022594-fx044gcd	13	10	is	be	VBZ
cord-022594-fx044gcd	13	11	now	now	RB
cord-022594-fx044gcd	13	12	clearly	clearly	RB
cord-022594-fx044gcd	13	13	recognizable	recognizable	JJ
cord-022594-fx044gcd	13	14	as	as	IN
cord-022594-fx044gcd	13	15	MS	MS	NNP
cord-022594-fx044gcd	13	16	in	in	IN
cord-022594-fx044gcd	13	17	his	-PRON-	PRP$
cord-022594-fx044gcd	13	18	atlas	atlas	NN
cord-022594-fx044gcd	13	19	of	of	IN
cord-022594-fx044gcd	13	20	anatomical	anatomical	JJ
cord-022594-fx044gcd	13	21	pathology	pathology	NN
cord-022594-fx044gcd	13	22	.	.	.
cord-022594-fx044gcd	14	1	Cruveilhier	Cruveilhier	NNP
cord-022594-fx044gcd	14	2	published	publish	VBD
cord-022594-fx044gcd	14	3	gross	gross	JJ
cord-022594-fx044gcd	14	4	pathological	pathological	JJ
cord-022594-fx044gcd	14	5	and	and	CC
cord-022594-fx044gcd	14	6	clinical	clinical	JJ
cord-022594-fx044gcd	14	7	descriptions	description	NNS
cord-022594-fx044gcd	14	8	of	of	IN
cord-022594-fx044gcd	14	9	MS	MS	NNP
cord-022594-fx044gcd	14	10	.	.	.
cord-022594-fx044gcd	15	1	Vulpian	Vulpian	NNP
cord-022594-fx044gcd	15	2	first	first	RB
cord-022594-fx044gcd	15	3	suggested	suggest	VBD
cord-022594-fx044gcd	15	4	the	the	DT
cord-022594-fx044gcd	15	5	rubric	rubric	NN
cord-022594-fx044gcd	15	6	of	of	IN
cord-022594-fx044gcd	15	7	"	"	``
cord-022594-fx044gcd	15	8	sclerose	sclerose	NNP
cord-022594-fx044gcd	15	9	en	en	IN
cord-022594-fx044gcd	15	10	plaque	plaque	NN
cord-022594-fx044gcd	15	11	"	"	''
cord-022594-fx044gcd	15	12	in	in	IN
cord-022594-fx044gcd	15	13	1866	1866	CD
cord-022594-fx044gcd	15	14	.	.	.
cord-022594-fx044gcd	16	1	Charcot	Charcot	NNP
cord-022594-fx044gcd	16	2	was	be	VBD
cord-022594-fx044gcd	16	3	primarily	primarily	RB
cord-022594-fx044gcd	16	4	responsible	responsible	JJ
cord-022594-fx044gcd	16	5	for	for	IN
cord-022594-fx044gcd	16	6	establishing	establish	VBG
cord-022594-fx044gcd	16	7	MS	MS	NNP
cord-022594-fx044gcd	16	8	as	as	IN
cord-022594-fx044gcd	16	9	a	a	DT
cord-022594-fx044gcd	16	10	unique	unique	JJ
cord-022594-fx044gcd	16	11	and	and	CC
cord-022594-fx044gcd	16	12	recognizable	recognizable	JJ
cord-022594-fx044gcd	16	13	syndrome	syndrome	NN
cord-022594-fx044gcd	16	14	.	.	.
cord-022594-fx044gcd	17	1	3	3	LS
cord-022594-fx044gcd	18	1	He	-PRON-	PRP
cord-022594-fx044gcd	18	2	also	also	RB
cord-022594-fx044gcd	18	3	described	describe	VBD
cord-022594-fx044gcd	18	4	the	the	DT
cord-022594-fx044gcd	18	5	clinical	clinical	JJ
cord-022594-fx044gcd	18	6	spectrum	spectrum	NN
cord-022594-fx044gcd	18	7	and	and	CC
cord-022594-fx044gcd	18	8	the	the	DT
cord-022594-fx044gcd	18	9	histological	histological	JJ
cord-022594-fx044gcd	18	10	appearance	appearance	NN
cord-022594-fx044gcd	18	11	.	.	.
cord-022594-fx044gcd	19	1	Pierre	Pierre	NNP
cord-022594-fx044gcd	19	2	Marie	Marie	NNP
cord-022594-fx044gcd	19	3	was	be	VBD
cord-022594-fx044gcd	19	4	the	the	DT
cord-022594-fx044gcd	19	5	first	first	JJ
cord-022594-fx044gcd	19	6	to	to	TO
cord-022594-fx044gcd	19	7	suggest	suggest	VB
cord-022594-fx044gcd	19	8	an	an	DT
cord-022594-fx044gcd	19	9	infectious	infectious	JJ
cord-022594-fx044gcd	19	10	cause	cause	NN
cord-022594-fx044gcd	19	11	of	of	IN
cord-022594-fx044gcd	19	12	MS	MS	NNP
cord-022594-fx044gcd	19	13	in	in	IN
cord-022594-fx044gcd	19	14	1884	1884	CD
cord-022594-fx044gcd	19	15	,	,	,
cord-022594-fx044gcd	19	16	a	a	DT
cord-022594-fx044gcd	19	17	hypothesis	hypothesis	NN
cord-022594-fx044gcd	19	18	that	that	WDT
cord-022594-fx044gcd	19	19	is	be	VBZ
cord-022594-fx044gcd	19	20	still	still	RB
cord-022594-fx044gcd	19	21	debated	debate	VBN
cord-022594-fx044gcd	19	22	.	.	.
cord-022594-fx044gcd	20	1	Toxins	toxin	NNS
cord-022594-fx044gcd	20	2	were	be	VBD
cord-022594-fx044gcd	20	3	also	also	RB
cord-022594-fx044gcd	20	4	considered	consider	VBN
cord-022594-fx044gcd	20	5	to	to	TO
cord-022594-fx044gcd	20	6	be	be	VB
cord-022594-fx044gcd	20	7	responsible	responsible	JJ
cord-022594-fx044gcd	20	8	in	in	IN
cord-022594-fx044gcd	20	9	the	the	DT
cord-022594-fx044gcd	20	10	early	early	JJ
cord-022594-fx044gcd	20	11	1900s	1900s	CD
cord-022594-fx044gcd	20	12	.	.	.
cord-022594-fx044gcd	21	1	A	a	DT
cord-022594-fx044gcd	21	2	major	major	JJ
cord-022594-fx044gcd	21	3	advance	advance	NN
cord-022594-fx044gcd	21	4	toward	toward	IN
cord-022594-fx044gcd	21	5	the	the	DT
cord-022594-fx044gcd	21	6	understanding	understanding	NN
cord-022594-fx044gcd	21	7	of	of	IN
cord-022594-fx044gcd	21	8	demyelinating	demyelinate	VBG
cord-022594-fx044gcd	21	9	diseases	disease	NNS
cord-022594-fx044gcd	21	10	was	be	VBD
cord-022594-fx044gcd	21	11	the	the	DT
cord-022594-fx044gcd	21	12	discovery	discovery	NN
cord-022594-fx044gcd	21	13	of	of	IN
cord-022594-fx044gcd	21	14	experimental	experimental	JJ
cord-022594-fx044gcd	21	15	allergic	allergic	JJ
cord-022594-fx044gcd	21	16	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	21	17	(	(	-LRB-
cord-022594-fx044gcd	21	18	EAE	EAE	NNP
cord-022594-fx044gcd	21	19	)	)	-RRB-
cord-022594-fx044gcd	21	20	by	by	IN
cord-022594-fx044gcd	21	21	Rivers	Rivers	NNPS
cord-022594-fx044gcd	21	22	in	in	IN
cord-022594-fx044gcd	21	23	1935	1935	CD
cord-022594-fx044gcd	21	24	.	.	.
cord-022594-fx044gcd	22	1	4	4	LS
cord-022594-fx044gcd	23	1	A	a	DT
cord-022594-fx044gcd	23	2	variety	variety	NN
cord-022594-fx044gcd	23	3	of	of	IN
cord-022594-fx044gcd	23	4	different	different	JJ
cord-022594-fx044gcd	23	5	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	23	6	diseases	disease	NNS
cord-022594-fx044gcd	23	7	have	have	VBP
cord-022594-fx044gcd	23	8	subsequently	subsequently	RB
cord-022594-fx044gcd	23	9	been	be	VBN
cord-022594-fx044gcd	23	10	described	describe	VBN
cord-022594-fx044gcd	23	11	(	(	-LRB-
cord-022594-fx044gcd	23	12	Table	table	NN
cord-022594-fx044gcd	23	13	48	48	CD
cord-022594-fx044gcd	23	14	-1	-1	CD
cord-022594-fx044gcd	23	15	)	)	-RRB-
cord-022594-fx044gcd	23	16	.	.	.
cord-022594-fx044gcd	24	1	Myelin	Myelin	NNP
cord-022594-fx044gcd	24	2	provides	provide	VBZ
cord-022594-fx044gcd	24	3	insulation	insulation	NN
cord-022594-fx044gcd	24	4	for	for	IN
cord-022594-fx044gcd	24	5	axons	axon	NNS
cord-022594-fx044gcd	24	6	and	and	CC
cord-022594-fx044gcd	24	7	is	be	VBZ
cord-022594-fx044gcd	24	8	necessary	necessary	JJ
cord-022594-fx044gcd	24	9	for	for	IN
cord-022594-fx044gcd	24	10	saltatory	saltatory	JJ
cord-022594-fx044gcd	24	11	conduction	conduction	NN
cord-022594-fx044gcd	24	12	.	.	.
cord-022594-fx044gcd	25	1	It	-PRON-	PRP
cord-022594-fx044gcd	25	2	is	be	VBZ
cord-022594-fx044gcd	25	3	composed	compose	VBN
cord-022594-fx044gcd	25	4	of	of	IN
cord-022594-fx044gcd	25	5	tightly	tightly	RB
cord-022594-fx044gcd	25	6	wrapped	wrap	VBN
cord-022594-fx044gcd	25	7	lipid	lipid	NN
cord-022594-fx044gcd	25	8	bilayers	bilayer	NNS
cord-022594-fx044gcd	25	9	with	with	IN
cord-022594-fx044gcd	25	10	specialized	specialized	JJ
cord-022594-fx044gcd	25	11	protein	protein	NN
cord-022594-fx044gcd	25	12	constituents	constituent	NNS
cord-022594-fx044gcd	25	13	.	.	.
cord-022594-fx044gcd	26	1	Peripheral	peripheral	JJ
cord-022594-fx044gcd	26	2	nervous	nervous	JJ
cord-022594-fx044gcd	26	3	system	system	NN
cord-022594-fx044gcd	26	4	(	(	-LRB-
cord-022594-fx044gcd	26	5	PNS	PNS	NNP
cord-022594-fx044gcd	26	6	)	)	-RRB-
cord-022594-fx044gcd	26	7	myelin	myelin	NN
cord-022594-fx044gcd	26	8	is	be	VBZ
cord-022594-fx044gcd	26	9	formed	form	VBN
cord-022594-fx044gcd	26	10	by	by	IN
cord-022594-fx044gcd	26	11	the	the	DT
cord-022594-fx044gcd	26	12	extension	extension	NN
cord-022594-fx044gcd	26	13	of	of	IN
cord-022594-fx044gcd	26	14	Schwann	Schwann	NNP
cord-022594-fx044gcd	26	15	cells	cell	NNS
cord-022594-fx044gcd	26	16	,	,	,
cord-022594-fx044gcd	26	17	and	and	CC
cord-022594-fx044gcd	26	18	central	central	JJ
cord-022594-fx044gcd	26	19	nervous	nervous	JJ
cord-022594-fx044gcd	26	20	system	system	NN
cord-022594-fx044gcd	26	21	(	(	-LRB-
cord-022594-fx044gcd	26	22	CNS	CNS	NNP
cord-022594-fx044gcd	26	23	)	)	-RRB-
cord-022594-fx044gcd	26	24	myelin	myelin	NN
cord-022594-fx044gcd	26	25	is	be	VBZ
cord-022594-fx044gcd	26	26	produced	produce	VBN
cord-022594-fx044gcd	26	27	by	by	IN
cord-022594-fx044gcd	26	28	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	26	29	.	.	.
cord-022594-fx044gcd	27	1	The	the	DT
cord-022594-fx044gcd	27	2	myelin	myelin	NN
cord-022594-fx044gcd	27	3	coating	coating	NN
cord-022594-fx044gcd	27	4	is	be	VBZ
cord-022594-fx044gcd	27	5	interrupted	interrupt	VBN
cord-022594-fx044gcd	27	6	at	at	IN
cord-022594-fx044gcd	27	7	regular	regular	JJ
cord-022594-fx044gcd	27	8	intervals	interval	NNS
cord-022594-fx044gcd	27	9	(	(	-LRB-
cord-022594-fx044gcd	27	10	nodes	node	NNS
cord-022594-fx044gcd	27	11	of	of	IN
cord-022594-fx044gcd	27	12	Ranvier	Ranvier	NNP
cord-022594-fx044gcd	27	13	)	)	-RRB-
cord-022594-fx044gcd	27	14	where	where	WRB
cord-022594-fx044gcd	27	15	the	the	DT
cord-022594-fx044gcd	27	16	axon	axon	NN
cord-022594-fx044gcd	27	17	membrane	membrane	NN
cord-022594-fx044gcd	27	18	with	with	IN
cord-022594-fx044gcd	27	19	its	-PRON-	PRP$
cord-022594-fx044gcd	27	20	concentration	concentration	NN
cord-022594-fx044gcd	27	21	of	of	IN
cord-022594-fx044gcd	27	22	voltagegated	voltagegate	VBN
cord-022594-fx044gcd	27	23	sodium	sodium	NN
cord-022594-fx044gcd	27	24	channels	channel	NNS
cord-022594-fx044gcd	27	25	is	be	VBZ
cord-022594-fx044gcd	27	26	exposed	expose	VBN
cord-022594-fx044gcd	27	27	to	to	IN
cord-022594-fx044gcd	27	28	the	the	DT
cord-022594-fx044gcd	27	29	extracellular	extracellular	JJ
cord-022594-fx044gcd	27	30	environment	environment	NN
cord-022594-fx044gcd	27	31	(	(	-LRB-
cord-022594-fx044gcd	27	32	Fig	fig	NN
cord-022594-fx044gcd	27	33	.	.	.
cord-022594-fx044gcd	28	1	48	48	CD
cord-022594-fx044gcd	28	2	-	-	SYM
cord-022594-fx044gcd	28	3	1	1	CD
cord-022594-fx044gcd	28	4	)	)	-RRB-
cord-022594-fx044gcd	28	5	.	.	.
cord-022594-fx044gcd	29	1	5	5	LS
cord-022594-fx044gcd	30	1	The	the	DT
cord-022594-fx044gcd	30	2	presence	presence	NN
cord-022594-fx044gcd	30	3	of	of	IN
cord-022594-fx044gcd	30	4	myelin	myelin	NN
cord-022594-fx044gcd	30	5	is	be	VBZ
cord-022594-fx044gcd	30	6	essential	essential	JJ
cord-022594-fx044gcd	30	7	to	to	TO
cord-022594-fx044gcd	30	8	maintain	maintain	VB
cord-022594-fx044gcd	30	9	conduction	conduction	NN
cord-022594-fx044gcd	30	10	velocity	velocity	NN
cord-022594-fx044gcd	30	11	;	;	:
cord-022594-fx044gcd	30	12	its	-PRON-	PRP$
cord-022594-fx044gcd	30	13	loss	loss	NN
cord-022594-fx044gcd	30	14	or	or	CC
cord-022594-fx044gcd	30	15	damage	damage	NN
cord-022594-fx044gcd	30	16	can	can	MD
cord-022594-fx044gcd	30	17	lead	lead	VB
cord-022594-fx044gcd	30	18	to	to	IN
cord-022594-fx044gcd	30	19	significantly	significantly	RB
cord-022594-fx044gcd	30	20	slower	slow	JJR
cord-022594-fx044gcd	30	21	conduction	conduction	NN
cord-022594-fx044gcd	30	22	or	or	CC
cord-022594-fx044gcd	30	23	conduction	conduction	NN
cord-022594-fx044gcd	30	24	block	block	NN
cord-022594-fx044gcd	30	25	.	.	.
cord-022594-fx044gcd	31	1	Other	other	JJ
cord-022594-fx044gcd	31	2	factors	factor	NNS
cord-022594-fx044gcd	31	3	affect	affect	VBP
cord-022594-fx044gcd	31	4	conduction	conduction	NN
cord-022594-fx044gcd	31	5	velocity	velocity	NN
cord-022594-fx044gcd	31	6	including	include	VBG
cord-022594-fx044gcd	31	7	certain	certain	JJ
cord-022594-fx044gcd	31	8	antibodies	antibody	NNS
cord-022594-fx044gcd	31	9	and	and	CC
cord-022594-fx044gcd	31	10	chemicals	chemical	NNS
cord-022594-fx044gcd	31	11	like	like	IN
cord-022594-fx044gcd	31	12	nitric	nitric	NN
cord-022594-fx044gcd	31	13	oxide	oxide	NN
cord-022594-fx044gcd	31	14	.	.	.
cord-022594-fx044gcd	32	1	In	in	IN
cord-022594-fx044gcd	32	2	certain	certain	JJ
cord-022594-fx044gcd	32	3	cases	case	NNS
cord-022594-fx044gcd	32	4	,	,	,
cord-022594-fx044gcd	32	5	blockade	blockade	NN
cord-022594-fx044gcd	32	6	may	may	MD
cord-022594-fx044gcd	32	7	be	be	VB
cord-022594-fx044gcd	32	8	the	the	DT
cord-022594-fx044gcd	32	9	initial	initial	JJ
cord-022594-fx044gcd	32	10	event	event	NN
cord-022594-fx044gcd	32	11	in	in	IN
cord-022594-fx044gcd	32	12	the	the	DT
cord-022594-fx044gcd	32	13	cascade	cascade	NN
cord-022594-fx044gcd	32	14	of	of	IN
cord-022594-fx044gcd	32	15	events	event	NNS
cord-022594-fx044gcd	32	16	leading	lead	VBG
cord-022594-fx044gcd	32	17	to	to	IN
cord-022594-fx044gcd	32	18	demyelination	demyelination	NN
cord-022594-fx044gcd	32	19	.	.	.
cord-022594-fx044gcd	33	1	CNS	CNS	NNP
cord-022594-fx044gcd	33	2	and	and	CC
cord-022594-fx044gcd	33	3	PNS	PNS	NNP
cord-022594-fx044gcd	33	4	myelin	myelin	NN
cord-022594-fx044gcd	33	5	differ	differ	VBP
cord-022594-fx044gcd	33	6	in	in	IN
cord-022594-fx044gcd	33	7	a	a	DT
cord-022594-fx044gcd	33	8	number	number	NN
cord-022594-fx044gcd	33	9	of	of	IN
cord-022594-fx044gcd	33	10	important	important	JJ
cord-022594-fx044gcd	33	11	ways	way	NNS
cord-022594-fx044gcd	33	12	.	.	.
cord-022594-fx044gcd	34	1	Schwann	Schwann	NNP
cord-022594-fx044gcd	34	2	cells	cell	NNS
cord-022594-fx044gcd	34	3	myelinate	myelinate	VBP
cord-022594-fx044gcd	34	4	only	only	RB
cord-022594-fx044gcd	34	5	one	one	CD
cord-022594-fx044gcd	34	6	internodal	internodal	JJ
cord-022594-fx044gcd	34	7	segment	segment	NN
cord-022594-fx044gcd	34	8	from	from	IN
cord-022594-fx044gcd	34	9	a	a	DT
cord-022594-fx044gcd	34	10	single	single	JJ
cord-022594-fx044gcd	34	11	PNS	PNS	NNP
cord-022594-fx044gcd	34	12	axon	axon	NN
cord-022594-fx044gcd	34	13	,	,	,
cord-022594-fx044gcd	34	14	whereas	whereas	IN
cord-022594-fx044gcd	34	15	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	34	16	myelinate	myelinate	JJ
cord-022594-fx044gcd	34	17	multiple	multiple	JJ
cord-022594-fx044gcd	34	18	CNS	CNS	NNP
cord-022594-fx044gcd	34	19	axons	axon	NNS
cord-022594-fx044gcd	34	20	.	.	.
cord-022594-fx044gcd	35	1	The	the	DT
cord-022594-fx044gcd	35	2	proteins	protein	NNS
cord-022594-fx044gcd	35	3	also	also	RB
cord-022594-fx044gcd	35	4	differ	differ	VBP
cord-022594-fx044gcd	35	5	.	.	.
cord-022594-fx044gcd	36	1	Proteolipid	Proteolipid	NNP
cord-022594-fx044gcd	36	2	protein	protein	NN
cord-022594-fx044gcd	36	3	(	(	-LRB-
cord-022594-fx044gcd	36	4	PLP	PLP	NNP
cord-022594-fx044gcd	36	5	)	)	-RRB-
cord-022594-fx044gcd	36	6	accounts	account	VBZ
cord-022594-fx044gcd	36	7	for	for	IN
cord-022594-fx044gcd	36	8	approximately	approximately	RB
cord-022594-fx044gcd	36	9	50	50	CD
cord-022594-fx044gcd	36	10	%	%	NN
cord-022594-fx044gcd	36	11	of	of	IN
cord-022594-fx044gcd	36	12	the	the	DT
cord-022594-fx044gcd	36	13	CNS	CNS	NNP
cord-022594-fx044gcd	36	14	myelin	myelin	NN
cord-022594-fx044gcd	36	15	proteins	protein	NNS
cord-022594-fx044gcd	36	16	.	.	.
cord-022594-fx044gcd	37	1	Mutations	mutation	NNS
cord-022594-fx044gcd	37	2	in	in	IN
cord-022594-fx044gcd	37	3	this	this	DT
cord-022594-fx044gcd	37	4	highly	highly	RB
cord-022594-fx044gcd	37	5	conserved	conserved	JJ
cord-022594-fx044gcd	37	6	protein	protein	NN
cord-022594-fx044gcd	37	7	cause	cause	IN
cord-022594-fx044gcd	37	8	Pelizaeus	Pelizaeus	NNP
cord-022594-fx044gcd	37	9	-	-	HYPH
cord-022594-fx044gcd	37	10	Merzbacher	Merzbacher	NNP
cord-022594-fx044gcd	37	11	disease	disease	NN
cord-022594-fx044gcd	37	12	.	.	.
cord-022594-fx044gcd	38	1	Protein	protein	NN
cord-022594-fx044gcd	38	2	zero	zero	CD
cord-022594-fx044gcd	38	3	is	be	VBZ
cord-022594-fx044gcd	38	4	the	the	DT
cord-022594-fx044gcd	38	5	major	major	JJ
cord-022594-fx044gcd	38	6	PNS	PNS	NNP
cord-022594-fx044gcd	38	7	myelin	myelin	NN
cord-022594-fx044gcd	38	8	protein	protein	NN
cord-022594-fx044gcd	38	9	and	and	CC
cord-022594-fx044gcd	38	10	performs	perform	VBZ
cord-022594-fx044gcd	38	11	a	a	DT
cord-022594-fx044gcd	38	12	function	function	NN
cord-022594-fx044gcd	38	13	similar	similar	JJ
cord-022594-fx044gcd	38	14	to	to	IN
cord-022594-fx044gcd	38	15	PLP	PLP	NNP
cord-022594-fx044gcd	38	16	in	in	IN
cord-022594-fx044gcd	38	17	compacting	compact	VBG
cord-022594-fx044gcd	38	18	the	the	DT
cord-022594-fx044gcd	38	19	intraperiod	intraperiod	NN
cord-022594-fx044gcd	38	20	line	line	NN
cord-022594-fx044gcd	38	21	.	.	.
cord-022594-fx044gcd	39	1	Myelin	myelin	JJ
cord-022594-fx044gcd	39	2	basic	basic	JJ
cord-022594-fx044gcd	39	3	protein	protein	NN
cord-022594-fx044gcd	39	4	(	(	-LRB-
cord-022594-fx044gcd	39	5	MBP	MBP	NNP
cord-022594-fx044gcd	39	6	)	)	-RRB-
cord-022594-fx044gcd	39	7	makes	make	VBZ
cord-022594-fx044gcd	39	8	up	up	RP
cord-022594-fx044gcd	39	9	30	30	CD
cord-022594-fx044gcd	39	10	%	%	NN
cord-022594-fx044gcd	39	11	of	of	IN
cord-022594-fx044gcd	39	12	CNS	CNS	NNP
cord-022594-fx044gcd	39	13	and	and	CC
cord-022594-fx044gcd	39	14	10	10	CD
cord-022594-fx044gcd	39	15	%	%	NN
cord-022594-fx044gcd	39	16	of	of	IN
cord-022594-fx044gcd	39	17	PNS	PNS	NNP
cord-022594-fx044gcd	39	18	myelin	myelin	NN
cord-022594-fx044gcd	39	19	proteins	protein	NNS
cord-022594-fx044gcd	39	20	.	.	.
cord-022594-fx044gcd	40	1	MBP	MBP	NNP
cord-022594-fx044gcd	40	2	is	be	VBZ
cord-022594-fx044gcd	40	3	not	not	RB
cord-022594-fx044gcd	40	4	an	an	DT
cord-022594-fx044gcd	40	5	integral	integral	JJ
cord-022594-fx044gcd	40	6	protein	protein	NN
cord-022594-fx044gcd	40	7	but	but	CC
cord-022594-fx044gcd	40	8	binds	bind	VBZ
cord-022594-fx044gcd	40	9	to	to	IN
cord-022594-fx044gcd	40	10	the	the	DT
cord-022594-fx044gcd	40	11	cytoplasmic	cytoplasmic	JJ
cord-022594-fx044gcd	40	12	surface	surface	NN
cord-022594-fx044gcd	40	13	and	and	CC
cord-022594-fx044gcd	40	14	is	be	VBZ
cord-022594-fx044gcd	40	15	responsible	responsible	JJ
cord-022594-fx044gcd	40	16	for	for	IN
cord-022594-fx044gcd	40	17	compaction	compaction	NN
cord-022594-fx044gcd	40	18	at	at	IN
cord-022594-fx044gcd	40	19	the	the	DT
cord-022594-fx044gcd	40	20	major	major	JJ
cord-022594-fx044gcd	40	21	dense	dense	JJ
cord-022594-fx044gcd	40	22	line	line	NN
cord-022594-fx044gcd	40	23	.	.	.
cord-022594-fx044gcd	41	1	Myelin	myelin	JJ
cord-022594-fx044gcd	41	2	associate	associate	NN
cord-022594-fx044gcd	41	3	glycoprotein	glycoprotein	NN
cord-022594-fx044gcd	41	4	accounts	account	VBZ
cord-022594-fx044gcd	41	5	for	for	IN
cord-022594-fx044gcd	41	6	about	about	RB
cord-022594-fx044gcd	41	7	1	1	CD
cord-022594-fx044gcd	41	8	%	%	NN
cord-022594-fx044gcd	41	9	of	of	IN
cord-022594-fx044gcd	41	10	both	both	CC
cord-022594-fx044gcd	41	11	peripheral	peripheral	JJ
cord-022594-fx044gcd	41	12	and	and	CC
cord-022594-fx044gcd	41	13	central	central	JJ
cord-022594-fx044gcd	41	14	myelin	myelin	NN
cord-022594-fx044gcd	41	15	.	.	.
cord-022594-fx044gcd	42	1	Myelin	Myelin	NNP
cord-022594-fx044gcd	42	2	oligodendrocyte	oligodendrocyte	VBN
cord-022594-fx044gcd	42	3	glycoprotein	glycoprotein	NN
cord-022594-fx044gcd	42	4	and	and	CC
cord-022594-fx044gcd	42	5	cyclic	cyclic	JJ
cord-022594-fx044gcd	42	6	nucleotide	nucleotide	JJ
cord-022594-fx044gcd	42	7	phosphodiesterase	phosphodiesterase	NN
cord-022594-fx044gcd	42	8	are	be	VBP
cord-022594-fx044gcd	42	9	minor	minor	JJ
cord-022594-fx044gcd	42	10	constituents	constituent	NNS
cord-022594-fx044gcd	42	11	of	of	IN
cord-022594-fx044gcd	42	12	CNS	CNS	NNP
cord-022594-fx044gcd	42	13	myelin	myelin	NN
cord-022594-fx044gcd	42	14	and	and	CC
cord-022594-fx044gcd	42	15	are	be	VBP
cord-022594-fx044gcd	42	16	not	not	RB
cord-022594-fx044gcd	42	17	found	find	VBN
cord-022594-fx044gcd	42	18	in	in	IN
cord-022594-fx044gcd	42	19	the	the	DT
cord-022594-fx044gcd	42	20	PNS	PNS	NNP
cord-022594-fx044gcd	42	21	.	.	.
cord-022594-fx044gcd	43	1	Peripheral	peripheral	JJ
cord-022594-fx044gcd	43	2	myelin	myelin	NN
cord-022594-fx044gcd	43	3	protein	protein	NN
cord-022594-fx044gcd	43	4	22	22	CD
cord-022594-fx044gcd	43	5	is	be	VBZ
cord-022594-fx044gcd	43	6	a	a	DT
cord-022594-fx044gcd	43	7	minor	minor	JJ
cord-022594-fx044gcd	43	8	component	component	NN
cord-022594-fx044gcd	43	9	of	of	IN
cord-022594-fx044gcd	43	10	PNS	PNS	NNP
cord-022594-fx044gcd	43	11	myelin	myelin	NN
cord-022594-fx044gcd	43	12	.	.	.
cord-022594-fx044gcd	44	1	MS	MS	NNP
cord-022594-fx044gcd	44	2	is	be	VBZ
cord-022594-fx044gcd	44	3	an	an	DT
cord-022594-fx044gcd	44	4	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	44	5	relapsing	relapse	VBG
cord-022594-fx044gcd	44	6	or	or	CC
cord-022594-fx044gcd	44	7	progressive	progressive	JJ
cord-022594-fx044gcd	44	8	disorder	disorder	NN
cord-022594-fx044gcd	44	9	of	of	IN
cord-022594-fx044gcd	44	10	CNS	CNS	NNP
cord-022594-fx044gcd	44	11	white	white	JJ
cord-022594-fx044gcd	44	12	matter	matter	NN
cord-022594-fx044gcd	44	13	and	and	CC
cord-022594-fx044gcd	44	14	is	be	VBZ
cord-022594-fx044gcd	44	15	a	a	DT
cord-022594-fx044gcd	44	16	major	major	JJ
cord-022594-fx044gcd	44	17	cause	cause	NN
cord-022594-fx044gcd	44	18	of	of	IN
cord-022594-fx044gcd	44	19	disability	disability	NN
cord-022594-fx044gcd	44	20	in	in	IN
cord-022594-fx044gcd	44	21	young	young	JJ
cord-022594-fx044gcd	44	22	adults	adult	NNS
cord-022594-fx044gcd	44	23	.	.	.
cord-022594-fx044gcd	45	1	Pathologically	pathologically	RB
cord-022594-fx044gcd	45	2	,	,	,
cord-022594-fx044gcd	45	3	it	-PRON-	PRP
cord-022594-fx044gcd	45	4	is	be	VBZ
cord-022594-fx044gcd	45	5	characterized	characterize	VBN
cord-022594-fx044gcd	45	6	by	by	IN
cord-022594-fx044gcd	45	7	multifocal	multifocal	JJ
cord-022594-fx044gcd	45	8	areas	area	NNS
cord-022594-fx044gcd	45	9	of	of	IN
cord-022594-fx044gcd	45	10	demyelination	demyelination	NN
cord-022594-fx044gcd	45	11	,	,	,
cord-022594-fx044gcd	45	12	loss	loss	NN
cord-022594-fx044gcd	45	13	of	of	IN
cord-022594-fx044gcd	45	14	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	45	15	,	,	,
cord-022594-fx044gcd	45	16	and	and	CC
cord-022594-fx044gcd	45	17	astrogliosis	astrogliosis	NN
cord-022594-fx044gcd	45	18	but	but	CC
cord-022594-fx044gcd	45	19	with	with	IN
cord-022594-fx044gcd	45	20	relative	relative	JJ
cord-022594-fx044gcd	45	21	preservation	preservation	NN
cord-022594-fx044gcd	45	22	of	of	IN
cord-022594-fx044gcd	45	23	axons	axon	NNS
cord-022594-fx044gcd	45	24	.	.	.
cord-022594-fx044gcd	46	1	While	while	IN
cord-022594-fx044gcd	46	2	demyelination	demyelination	NN
cord-022594-fx044gcd	46	3	is	be	VBZ
cord-022594-fx044gcd	46	4	the	the	DT
cord-022594-fx044gcd	46	5	classic	classic	JJ
cord-022594-fx044gcd	46	6	hallmark	hallmark	NN
cord-022594-fx044gcd	46	7	of	of	IN
cord-022594-fx044gcd	46	8	MS	MS	NNP
cord-022594-fx044gcd	46	9	,	,	,
cord-022594-fx044gcd	46	10	axonal	axonal	JJ
cord-022594-fx044gcd	46	11	and	and	CC
cord-022594-fx044gcd	46	12	neuronal	neuronal	JJ
cord-022594-fx044gcd	46	13	injury	injury	NN
cord-022594-fx044gcd	46	14	are	be	VBP
cord-022594-fx044gcd	46	15	important	important	JJ
cord-022594-fx044gcd	46	16	aspects	aspect	NNS
cord-022594-fx044gcd	46	17	of	of	IN
cord-022594-fx044gcd	46	18	the	the	DT
cord-022594-fx044gcd	46	19	disease	disease	NN
cord-022594-fx044gcd	46	20	and	and	CC
cord-022594-fx044gcd	46	21	are	be	VBP
cord-022594-fx044gcd	46	22	gaining	gain	VBG
cord-022594-fx044gcd	46	23	more	more	JJR
cord-022594-fx044gcd	46	24	recognition	recognition	NN
cord-022594-fx044gcd	46	25	.	.	.
cord-022594-fx044gcd	47	1	Although	although	IN
cord-022594-fx044gcd	47	2	certain	certain	JJ
cord-022594-fx044gcd	47	3	clinical	clinical	JJ
cord-022594-fx044gcd	47	4	features	feature	NNS
cord-022594-fx044gcd	47	5	are	be	VBP
cord-022594-fx044gcd	47	6	characteristic	characteristic	JJ
cord-022594-fx044gcd	47	7	of	of	IN
cord-022594-fx044gcd	47	8	MS	MS	NNP
cord-022594-fx044gcd	47	9	,	,	,
cord-022594-fx044gcd	47	10	investigative	investigative	JJ
cord-022594-fx044gcd	47	11	studies	study	NNS
cord-022594-fx044gcd	47	12	are	be	VBP
cord-022594-fx044gcd	47	13	often	often	RB
cord-022594-fx044gcd	47	14	needed	need	VBN
cord-022594-fx044gcd	47	15	to	to	TO
cord-022594-fx044gcd	47	16	confirm	confirm	VB
cord-022594-fx044gcd	47	17	the	the	DT
cord-022594-fx044gcd	47	18	clinical	clinical	JJ
cord-022594-fx044gcd	47	19	suspicion	suspicion	NN
cord-022594-fx044gcd	47	20	and	and	CC
cord-022594-fx044gcd	47	21	exclude	exclude	VB
cord-022594-fx044gcd	47	22	other	other	JJ
cord-022594-fx044gcd	47	23	possibilities	possibility	NNS
cord-022594-fx044gcd	47	24	.	.	.
cord-022594-fx044gcd	48	1	Recently	recently	RB
cord-022594-fx044gcd	48	2	,	,	,
cord-022594-fx044gcd	48	3	there	there	EX
cord-022594-fx044gcd	48	4	have	have	VBP
cord-022594-fx044gcd	48	5	been	be	VBN
cord-022594-fx044gcd	48	6	advances	advance	NNS
cord-022594-fx044gcd	48	7	in	in	IN
cord-022594-fx044gcd	48	8	understanding	understand	VBG
cord-022594-fx044gcd	48	9	the	the	DT
cord-022594-fx044gcd	48	10	etiology	etiology	NN
cord-022594-fx044gcd	48	11	,	,	,
cord-022594-fx044gcd	48	12	mechanisms	mechanism	NNS
cord-022594-fx044gcd	48	13	of	of	IN
cord-022594-fx044gcd	48	14	myelin	myelin	NN
cord-022594-fx044gcd	48	15	injury	injury	NN
cord-022594-fx044gcd	48	16	,	,	,
cord-022594-fx044gcd	48	17	and	and	CC
cord-022594-fx044gcd	48	18	potential	potential	NN
cord-022594-fx044gcd	48	19	for	for	IN
cord-022594-fx044gcd	48	20	repair	repair	NN
cord-022594-fx044gcd	48	21	,	,	,
cord-022594-fx044gcd	48	22	and	and	CC
cord-022594-fx044gcd	48	23	several	several	JJ
cord-022594-fx044gcd	48	24	partially	partially	RB
cord-022594-fx044gcd	48	25	effective	effective	JJ
cord-022594-fx044gcd	48	26	agents	agent	NNS
cord-022594-fx044gcd	48	27	are	be	VBP
cord-022594-fx044gcd	48	28	now	now	RB
cord-022594-fx044gcd	48	29	approved	approve	VBN
cord-022594-fx044gcd	48	30	for	for	IN
cord-022594-fx044gcd	48	31	use	use	NN
cord-022594-fx044gcd	48	32	in	in	IN
cord-022594-fx044gcd	48	33	relapsing	relapse	VBG
cord-022594-fx044gcd	48	34	-	-	HYPH
cord-022594-fx044gcd	48	35	remitting	remit	VBG
cord-022594-fx044gcd	48	36	and	and	CC
cord-022594-fx044gcd	48	37	secondary	secondary	JJ
cord-022594-fx044gcd	48	38	progressive	progressive	JJ
cord-022594-fx044gcd	48	39	MS	MS	NNP
cord-022594-fx044gcd	48	40	.	.	.
cord-022594-fx044gcd	49	1	The	the	DT
cord-022594-fx044gcd	49	2	pathogenesis	pathogenesis	NN
cord-022594-fx044gcd	49	3	and	and	CC
cord-022594-fx044gcd	49	4	pathophysiology	pathophysiology	NN
cord-022594-fx044gcd	49	5	of	of	IN
cord-022594-fx044gcd	49	6	MS	MS	NNP
cord-022594-fx044gcd	49	7	remains	remain	VBZ
cord-022594-fx044gcd	49	8	incompletely	incompletely	RB
cord-022594-fx044gcd	49	9	understood	understand	VBN
cord-022594-fx044gcd	49	10	.	.	.
cord-022594-fx044gcd	50	1	Several	several	JJ
cord-022594-fx044gcd	50	2	mechanisms	mechanism	NNS
cord-022594-fx044gcd	50	3	may	may	MD
cord-022594-fx044gcd	50	4	be	be	VB
cord-022594-fx044gcd	50	5	important	important	JJ
cord-022594-fx044gcd	50	6	to	to	IN
cord-022594-fx044gcd	50	7	MS	MS	NNP
cord-022594-fx044gcd	50	8	plaque	plaque	NN
cord-022594-fx044gcd	50	9	formation	formation	NN
cord-022594-fx044gcd	50	10	:	:	:
cord-022594-fx044gcd	51	1	autoimmunity	autoimmunity	NN
cord-022594-fx044gcd	51	2	,	,	,
cord-022594-fx044gcd	51	3	infection	infection	NN
cord-022594-fx044gcd	51	4	,	,	,
cord-022594-fx044gcd	51	5	bystander	bystander	NN
cord-022594-fx044gcd	51	6	demyelination	demyelination	NN
cord-022594-fx044gcd	51	7	,	,	,
cord-022594-fx044gcd	51	8	and	and	CC
cord-022594-fx044gcd	51	9	heredity	heredity	NN
cord-022594-fx044gcd	51	10	.	.	.
cord-022594-fx044gcd	52	1	Although	although	IN
cord-022594-fx044gcd	52	2	convincing	convincing	JJ
cord-022594-fx044gcd	52	3	proof	proof	NN
cord-022594-fx044gcd	52	4	is	be	VBZ
cord-022594-fx044gcd	52	5	lacking	lack	VBG
cord-022594-fx044gcd	52	6	,	,	,
cord-022594-fx044gcd	52	7	dietary	dietary	JJ
cord-022594-fx044gcd	52	8	factors	factor	NNS
cord-022594-fx044gcd	52	9	and	and	CC
cord-022594-fx044gcd	52	10	toxin	toxin	NN
cord-022594-fx044gcd	52	11	exposure	exposure	NN
cord-022594-fx044gcd	52	12	have	have	VBP
cord-022594-fx044gcd	52	13	been	be	VBN
cord-022594-fx044gcd	52	14	hypothesized	hypothesize	VBN
cord-022594-fx044gcd	52	15	to	to	TO
cord-022594-fx044gcd	52	16	contribute	contribute	VB
cord-022594-fx044gcd	52	17	as	as	RB
cord-022594-fx044gcd	52	18	well	well	RB
cord-022594-fx044gcd	52	19	.	.	.
cord-022594-fx044gcd	53	1	These	these	DT
cord-022594-fx044gcd	53	2	mechanisms	mechanism	NNS
cord-022594-fx044gcd	53	3	are	be	VBP
cord-022594-fx044gcd	53	4	not	not	RB
cord-022594-fx044gcd	53	5	mutually	mutually	RB
cord-022594-fx044gcd	53	6	exclusive	exclusive	JJ
cord-022594-fx044gcd	53	7	,	,	,
cord-022594-fx044gcd	53	8	and	and	CC
cord-022594-fx044gcd	53	9	the	the	DT
cord-022594-fx044gcd	53	10	true	true	JJ
cord-022594-fx044gcd	53	11	pathophysiology	pathophysiology	NN
cord-022594-fx044gcd	53	12	is	be	VBZ
cord-022594-fx044gcd	53	13	likely	likely	JJ
cord-022594-fx044gcd	53	14	to	to	TO
cord-022594-fx044gcd	53	15	depend	depend	VB
cord-022594-fx044gcd	53	16	on	on	IN
cord-022594-fx044gcd	53	17	more	more	JJR
cord-022594-fx044gcd	53	18	than	than	IN
cord-022594-fx044gcd	53	19	one	one	CD
cord-022594-fx044gcd	53	20	of	of	IN
cord-022594-fx044gcd	53	21	them	-PRON-	PRP
cord-022594-fx044gcd	53	22	.	.	.
cord-022594-fx044gcd	54	1	Autoimmunity	Autoimmunity	NNP
cord-022594-fx044gcd	54	2	.	.	.
cord-022594-fx044gcd	55	1	During	during	IN
cord-022594-fx044gcd	55	2	ontogenesis	ontogenesis	NN
cord-022594-fx044gcd	55	3	,	,	,
cord-022594-fx044gcd	55	4	autoreactive	autoreactive	JJ
cord-022594-fx044gcd	55	5	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	55	6	normally	normally	RB
cord-022594-fx044gcd	55	7	undergo	undergo	VBP
cord-022594-fx044gcd	55	8	clonal	clonal	JJ
cord-022594-fx044gcd	55	9	depletion	depletion	NN
cord-022594-fx044gcd	55	10	,	,	,
cord-022594-fx044gcd	55	11	but	but	CC
cord-022594-fx044gcd	55	12	some	some	DT
cord-022594-fx044gcd	55	13	escape	escape	NN
cord-022594-fx044gcd	55	14	and	and	CC
cord-022594-fx044gcd	55	15	are	be	VBP
cord-022594-fx044gcd	55	16	merely	merely	RB
cord-022594-fx044gcd	55	17	suppressed	suppress	VBN
cord-022594-fx044gcd	55	18	,	,	,
cord-022594-fx044gcd	55	19	becoming	become	VBG
cord-022594-fx044gcd	55	20	tolerant	tolerant	JJ
cord-022594-fx044gcd	55	21	to	to	IN
cord-022594-fx044gcd	55	22	their	-PRON-	PRP$
cord-022594-fx044gcd	55	23	antigens	antigen	NNS
cord-022594-fx044gcd	55	24	.	.	.
cord-022594-fx044gcd	56	1	Low	low	JJ
cord-022594-fx044gcd	56	2	levels	level	NNS
cord-022594-fx044gcd	56	3	of	of	IN
cord-022594-fx044gcd	56	4	autoreactive	autoreactive	JJ
cord-022594-fx044gcd	56	5	T	t	NN
cord-022594-fx044gcd	56	6	and	and	CC
cord-022594-fx044gcd	56	7	B	b	NN
cord-022594-fx044gcd	56	8	cells	cell	NNS
cord-022594-fx044gcd	56	9	persist	persist	VBP
cord-022594-fx044gcd	56	10	even	even	RB
cord-022594-fx044gcd	56	11	in	in	IN
cord-022594-fx044gcd	56	12	normal	normal	JJ
cord-022594-fx044gcd	56	13	individuals	individual	NNS
cord-022594-fx044gcd	56	14	.	.	.
cord-022594-fx044gcd	57	1	Autoimmune	autoimmune	JJ
cord-022594-fx044gcd	57	2	disorders	disorder	NNS
cord-022594-fx044gcd	57	3	occur	occur	VBP
cord-022594-fx044gcd	57	4	when	when	WRB
cord-022594-fx044gcd	57	5	the	the	DT
cord-022594-fx044gcd	57	6	tolerance	tolerance	NN
cord-022594-fx044gcd	57	7	of	of	IN
cord-022594-fx044gcd	57	8	these	these	DT
cord-022594-fx044gcd	57	9	cells	cell	NNS
cord-022594-fx044gcd	57	10	toward	toward	IN
cord-022594-fx044gcd	57	11	their	-PRON-	PRP$
cord-022594-fx044gcd	57	12	antigen	antigen	NN
cord-022594-fx044gcd	57	13	is	be	VBZ
cord-022594-fx044gcd	57	14	broken	break	VBN
cord-022594-fx044gcd	57	15	.	.	.
cord-022594-fx044gcd	58	1	The	the	DT
cord-022594-fx044gcd	58	2	decreased	decreased	JJ
cord-022594-fx044gcd	58	3	suppressor	suppressor	NN
cord-022594-fx044gcd	58	4	activity	activity	NN
cord-022594-fx044gcd	58	5	of	of	IN
cord-022594-fx044gcd	58	6	circulating	circulate	VBG
cord-022594-fx044gcd	58	7	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	58	8	from	from	IN
cord-022594-fx044gcd	58	9	patients	patient	NNS
cord-022594-fx044gcd	58	10	with	with	IN
cord-022594-fx044gcd	58	11	MS	MS	NNP
cord-022594-fx044gcd	58	12	and	and	CC
cord-022594-fx044gcd	58	13	other	other	JJ
cord-022594-fx044gcd	58	14	presumed	presume	VBN
cord-022594-fx044gcd	58	15	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	58	16	diseases	disease	NNS
cord-022594-fx044gcd	58	17	may	may	MD
cord-022594-fx044gcd	58	18	reflect	reflect	VB
cord-022594-fx044gcd	58	19	loss	loss	NN
cord-022594-fx044gcd	58	20	of	of	IN
cord-022594-fx044gcd	58	21	tolerance	tolerance	NN
cord-022594-fx044gcd	58	22	.	.	.
cord-022594-fx044gcd	59	1	6	6	CD
cord-022594-fx044gcd	60	1	One	one	CD
cord-022594-fx044gcd	60	2	potential	potential	JJ
cord-022594-fx044gcd	60	3	mechanism	mechanism	NN
cord-022594-fx044gcd	60	4	that	that	WDT
cord-022594-fx044gcd	60	5	may	may	MD
cord-022594-fx044gcd	60	6	break	break	VB
cord-022594-fx044gcd	60	7	tolerance	tolerance	NN
cord-022594-fx044gcd	60	8	is	be	VBZ
cord-022594-fx044gcd	60	9	molecular	molecular	JJ
cord-022594-fx044gcd	60	10	mimicry	mimicry	NN
cord-022594-fx044gcd	60	11	between	between	IN
cord-022594-fx044gcd	60	12	self	self	NN
cord-022594-fx044gcd	60	13	and	and	CC
cord-022594-fx044gcd	60	14	foreign	foreign	JJ
cord-022594-fx044gcd	60	15	antigens	antigen	NNS
cord-022594-fx044gcd	60	16	.	.	.
cord-022594-fx044gcd	61	1	Autoreactive	autoreactive	JJ
cord-022594-fx044gcd	61	2	T4	T4	NNP
cord-022594-fx044gcd	61	3	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	61	4	may	may	MD
cord-022594-fx044gcd	61	5	become	become	VB
cord-022594-fx044gcd	61	6	activated	activate	VBN
cord-022594-fx044gcd	61	7	on	on	IN
cord-022594-fx044gcd	61	8	exposure	exposure	NN
cord-022594-fx044gcd	61	9	to	to	IN
cord-022594-fx044gcd	61	10	structurally	structurally	RB
cord-022594-fx044gcd	61	11	similar	similar	JJ
cord-022594-fx044gcd	61	12	foreign	foreign	JJ
cord-022594-fx044gcd	61	13	antigens	antigen	NNS
cord-022594-fx044gcd	61	14	.	.	.
cord-022594-fx044gcd	62	1	Some	some	DT
cord-022594-fx044gcd	62	2	evidence	evidence	NN
cord-022594-fx044gcd	62	3	suggests	suggest	VBZ
cord-022594-fx044gcd	62	4	that	that	IN
cord-022594-fx044gcd	62	5	molecular	molecular	JJ
cord-022594-fx044gcd	62	6	mimicry	mimicry	NN
cord-022594-fx044gcd	62	7	is	be	VBZ
cord-022594-fx044gcd	62	8	relevant	relevant	JJ
cord-022594-fx044gcd	62	9	in	in	IN
cord-022594-fx044gcd	62	10	MS	MS	NNP
cord-022594-fx044gcd	62	11	.	.	.
cord-022594-fx044gcd	63	1	Not	not	RB
cord-022594-fx044gcd	63	2	only	only	RB
cord-022594-fx044gcd	63	3	do	do	VBP
cord-022594-fx044gcd	63	4	several	several	JJ
cord-022594-fx044gcd	63	5	viral	viral	JJ
cord-022594-fx044gcd	63	6	and	and	CC
cord-022594-fx044gcd	63	7	bacterial	bacterial	JJ
cord-022594-fx044gcd	63	8	peptides	peptide	NNS
cord-022594-fx044gcd	63	9	share	share	VBP
cord-022594-fx044gcd	63	10	structural	structural	JJ
cord-022594-fx044gcd	63	11	similarities	similarity	NNS
cord-022594-fx044gcd	63	12	with	with	IN
cord-022594-fx044gcd	63	13	MBP	MBP	NNP
cord-022594-fx044gcd	63	14	,	,	,
cord-022594-fx044gcd	63	15	but	but	CC
cord-022594-fx044gcd	63	16	it	-PRON-	PRP
cord-022594-fx044gcd	63	17	has	have	VBZ
cord-022594-fx044gcd	63	18	also	also	RB
cord-022594-fx044gcd	63	19	been	be	VBN
cord-022594-fx044gcd	63	20	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	63	21	that	that	IN
cord-022594-fx044gcd	63	22	these	these	DT
cord-022594-fx044gcd	63	23	antigens	antigen	NNS
cord-022594-fx044gcd	63	24	may	may	MD
cord-022594-fx044gcd	63	25	activate	activate	VB
cord-022594-fx044gcd	63	26	MBP	MBP	NNP
cord-022594-fx044gcd	63	27	-	-	HYPH
cord-022594-fx044gcd	63	28	specific	specific	JJ
cord-022594-fx044gcd	63	29	T	t	NN
cord-022594-fx044gcd	63	30	-	-	HYPH
cord-022594-fx044gcd	63	31	cell	cell	NN
cord-022594-fx044gcd	63	32	clones	clone	NNS
cord-022594-fx044gcd	63	33	derived	derive	VBN
cord-022594-fx044gcd	63	34	from	from	IN
cord-022594-fx044gcd	63	35	MS	MS	NNP
cord-022594-fx044gcd	63	36	patients	patient	NNS
cord-022594-fx044gcd	63	37	.	.	.
cord-022594-fx044gcd	64	1	7	7	CD
cord-022594-fx044gcd	64	2	Blood	blood	NN
cord-022594-fx044gcd	64	3	-	-	HYPH
cord-022594-fx044gcd	64	4	brain	brain	NN
cord-022594-fx044gcd	64	5	barrier	barrier	NN
cord-022594-fx044gcd	64	6	leakage	leakage	NN
cord-022594-fx044gcd	64	7	alone	alone	RB
cord-022594-fx044gcd	64	8	may	may	MD
cord-022594-fx044gcd	64	9	break	break	VB
cord-022594-fx044gcd	64	10	tolerance	tolerance	NN
cord-022594-fx044gcd	64	11	because	because	IN
cord-022594-fx044gcd	64	12	it	-PRON-	PRP
cord-022594-fx044gcd	64	13	gives	give	VBZ
cord-022594-fx044gcd	64	14	CNSreactive	cnsreactive	JJ
cord-022594-fx044gcd	64	15	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	64	16	easy	easy	JJ
cord-022594-fx044gcd	64	17	access	access	NN
cord-022594-fx044gcd	64	18	to	to	IN
cord-022594-fx044gcd	64	19	otherwise	otherwise	RB
cord-022594-fx044gcd	64	20	inaccessible	inaccessible	JJ
cord-022594-fx044gcd	64	21	antigens	antigen	NNS
cord-022594-fx044gcd	64	22	.	.	.
cord-022594-fx044gcd	65	1	Alternatively	alternatively	RB
cord-022594-fx044gcd	65	2	,	,	,
cord-022594-fx044gcd	65	3	a	a	DT
cord-022594-fx044gcd	65	4	primary	primary	JJ
cord-022594-fx044gcd	65	5	event	event	NN
cord-022594-fx044gcd	65	6	such	such	JJ
cord-022594-fx044gcd	65	7	as	as	IN
cord-022594-fx044gcd	65	8	an	an	DT
cord-022594-fx044gcd	65	9	infection	infection	NN
cord-022594-fx044gcd	65	10	or	or	CC
cord-022594-fx044gcd	65	11	injury	injury	NN
cord-022594-fx044gcd	65	12	may	may	MD
cord-022594-fx044gcd	65	13	release	release	VB
cord-022594-fx044gcd	65	14	CNS	CNS	NNP
cord-022594-fx044gcd	65	15	antigens	antigen	NNS
cord-022594-fx044gcd	65	16	into	into	IN
cord-022594-fx044gcd	65	17	the	the	DT
cord-022594-fx044gcd	65	18	periphery	periphery	NN
cord-022594-fx044gcd	65	19	,	,	,
cord-022594-fx044gcd	65	20	where	where	WRB
cord-022594-fx044gcd	65	21	they	-PRON-	PRP
cord-022594-fx044gcd	65	22	may	may	MD
cord-022594-fx044gcd	65	23	activate	activate	VB
cord-022594-fx044gcd	65	24	corresponding	correspond	VBG
cord-022594-fx044gcd	65	25	autoreactive	autoreactive	JJ
cord-022594-fx044gcd	65	26	cells	cell	NNS
cord-022594-fx044gcd	65	27	.	.	.
cord-022594-fx044gcd	66	1	8	8	CD
cord-022594-fx044gcd	67	1	The	the	DT
cord-022594-fx044gcd	67	2	major	major	JJ
cord-022594-fx044gcd	67	3	support	support	NN
cord-022594-fx044gcd	67	4	for	for	IN
cord-022594-fx044gcd	67	5	autoimmunity	autoimmunity	NN
cord-022594-fx044gcd	67	6	in	in	IN
cord-022594-fx044gcd	67	7	the	the	DT
cord-022594-fx044gcd	67	8	pathogenesis	pathogenesis	NN
cord-022594-fx044gcd	67	9	and	and	CC
cord-022594-fx044gcd	67	10	pathophysiology	pathophysiology	NN
cord-022594-fx044gcd	67	11	of	of	IN
cord-022594-fx044gcd	67	12	MS	MS	NNP
cord-022594-fx044gcd	67	13	is	be	VBZ
cord-022594-fx044gcd	67	14	by	by	IN
cord-022594-fx044gcd	67	15	analogy	analogy	NN
cord-022594-fx044gcd	67	16	to	to	IN
cord-022594-fx044gcd	67	17	EAE	EAE	NNP
cord-022594-fx044gcd	67	18	,	,	,
cord-022594-fx044gcd	67	19	the	the	DT
cord-022594-fx044gcd	67	20	major	major	JJ
cord-022594-fx044gcd	67	21	animal	animal	NN
cord-022594-fx044gcd	67	22	model	model	NN
cord-022594-fx044gcd	67	23	for	for	IN
cord-022594-fx044gcd	67	24	MS	MS	NNP
cord-022594-fx044gcd	67	25	.	.	.
cord-022594-fx044gcd	68	1	EAE	EAE	NNP
cord-022594-fx044gcd	68	2	is	be	VBZ
cord-022594-fx044gcd	68	3	,	,	,
cord-022594-fx044gcd	68	4	however	however	RB
cord-022594-fx044gcd	68	5	,	,	,
cord-022594-fx044gcd	68	6	an	an	DT
cord-022594-fx044gcd	68	7	artificial	artificial	JJ
cord-022594-fx044gcd	68	8	situation	situation	NN
cord-022594-fx044gcd	68	9	and	and	CC
cord-022594-fx044gcd	68	10	there	there	EX
cord-022594-fx044gcd	68	11	is	be	VBZ
cord-022594-fx044gcd	68	12	no	no	DT
cord-022594-fx044gcd	68	13	spontaneous	spontaneous	JJ
cord-022594-fx044gcd	68	14	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	68	15	animal	animal	NN
cord-022594-fx044gcd	68	16	model	model	NN
cord-022594-fx044gcd	68	17	of	of	IN
cord-022594-fx044gcd	68	18	MS	MS	NNP
cord-022594-fx044gcd	68	19	.	.	.
cord-022594-fx044gcd	69	1	While	while	IN
cord-022594-fx044gcd	69	2	EAE	EAE	NNP
cord-022594-fx044gcd	69	3	is	be	VBZ
cord-022594-fx044gcd	69	4	the	the	DT
cord-022594-fx044gcd	69	5	most	most	RBS
cord-022594-fx044gcd	69	6	commonly	commonly	RB
cord-022594-fx044gcd	69	7	studied	study	VBN
cord-022594-fx044gcd	69	8	model	model	NN
cord-022594-fx044gcd	69	9	of	of	IN
cord-022594-fx044gcd	69	10	MS	MS	NNP
cord-022594-fx044gcd	69	11	,	,	,
cord-022594-fx044gcd	69	12	several	several	JJ
cord-022594-fx044gcd	69	13	features	feature	NNS
cord-022594-fx044gcd	69	14	of	of	IN
cord-022594-fx044gcd	69	15	human	human	JJ
cord-022594-fx044gcd	69	16	MS	MS	NNP
cord-022594-fx044gcd	69	17	can	can	MD
cord-022594-fx044gcd	69	18	not	not	RB
cord-022594-fx044gcd	69	19	be	be	VB
cord-022594-fx044gcd	69	20	adequately	adequately	RB
cord-022594-fx044gcd	69	21	captured	capture	VBN
cord-022594-fx044gcd	69	22	by	by	IN
cord-022594-fx044gcd	69	23	this	this	DT
cord-022594-fx044gcd	69	24	model	model	NN
cord-022594-fx044gcd	69	25	.	.	.
cord-022594-fx044gcd	70	1	9	9	CD
cord-022594-fx044gcd	70	2	,	,	,
cord-022594-fx044gcd	70	3	10	10	CD
cord-022594-fx044gcd	70	4	Over	over	IN
cord-022594-fx044gcd	70	5	a	a	DT
cord-022594-fx044gcd	70	6	hundred	hundred	CD
cord-022594-fx044gcd	70	7	different	different	JJ
cord-022594-fx044gcd	70	8	effective	effective	JJ
cord-022594-fx044gcd	70	9	treatments	treatment	NNS
cord-022594-fx044gcd	70	10	have	have	VBP
cord-022594-fx044gcd	70	11	been	be	VBN
cord-022594-fx044gcd	70	12	described	describe	VBN
cord-022594-fx044gcd	70	13	for	for	IN
cord-022594-fx044gcd	70	14	EAE	EAE	NNP
cord-022594-fx044gcd	70	15	;	;	:
cord-022594-fx044gcd	70	16	however	however	RB
cord-022594-fx044gcd	70	17	,	,	,
cord-022594-fx044gcd	70	18	almost	almost	RB
cord-022594-fx044gcd	70	19	all	all	DT
cord-022594-fx044gcd	70	20	of	of	IN
cord-022594-fx044gcd	70	21	them	-PRON-	PRP
cord-022594-fx044gcd	70	22	are	be	VBP
cord-022594-fx044gcd	70	23	ineffective	ineffective	JJ
cord-022594-fx044gcd	70	24	and	and	CC
cord-022594-fx044gcd	70	25	some	some	DT
cord-022594-fx044gcd	70	26	are	be	VBP
cord-022594-fx044gcd	70	27	harmful	harmful	JJ
cord-022594-fx044gcd	70	28	in	in	IN
cord-022594-fx044gcd	70	29	human	human	JJ
cord-022594-fx044gcd	70	30	MS	MS	NNP
cord-022594-fx044gcd	70	31	.	.	.
cord-022594-fx044gcd	71	1	A	a	DT
cord-022594-fx044gcd	71	2	recent	recent	JJ
cord-022594-fx044gcd	71	3	editorial	editorial	NN
cord-022594-fx044gcd	71	4	discusses	discuss	VBZ
cord-022594-fx044gcd	71	5	the	the	DT
cord-022594-fx044gcd	71	6	merits	merit	NNS
cord-022594-fx044gcd	71	7	and	and	CC
cord-022594-fx044gcd	71	8	important	important	JJ
cord-022594-fx044gcd	71	9	limitations	limitation	NNS
cord-022594-fx044gcd	71	10	of	of	IN
cord-022594-fx044gcd	71	11	EAE	EAE	NNP
cord-022594-fx044gcd	71	12	as	as	IN
cord-022594-fx044gcd	71	13	a	a	DT
cord-022594-fx044gcd	71	14	model	model	NN
cord-022594-fx044gcd	71	15	for	for	IN
cord-022594-fx044gcd	71	16	MS	MS	NNP
cord-022594-fx044gcd	71	17	.	.	.
cord-022594-fx044gcd	72	1	10	10	CD
cord-022594-fx044gcd	73	1	In	in	IN
cord-022594-fx044gcd	73	2	EAE	EAE	NNP
cord-022594-fx044gcd	73	3	,	,	,
cord-022594-fx044gcd	73	4	just	just	RB
cord-022594-fx044gcd	73	5	like	like	IN
cord-022594-fx044gcd	73	6	in	in	IN
cord-022594-fx044gcd	73	7	classic	classic	JJ
cord-022594-fx044gcd	73	8	human	human	JJ
cord-022594-fx044gcd	73	9	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	73	10	diseases	disease	NNS
cord-022594-fx044gcd	73	11	such	such	JJ
cord-022594-fx044gcd	73	12	as	as	IN
cord-022594-fx044gcd	73	13	systemic	systemic	JJ
cord-022594-fx044gcd	73	14	lupus	lupus	NN
cord-022594-fx044gcd	73	15	erythematosus	erythematosus	NN
cord-022594-fx044gcd	73	16	(	(	-LRB-
cord-022594-fx044gcd	73	17	SLE	SLE	NNP
cord-022594-fx044gcd	73	18	)	)	-RRB-
cord-022594-fx044gcd	73	19	or	or	CC
cord-022594-fx044gcd	73	20	rheumatoid	rheumatoid	JJ
cord-022594-fx044gcd	73	21	arthritis	arthritis	NN
cord-022594-fx044gcd	73	22	,	,	,
cord-022594-fx044gcd	73	23	the	the	DT
cord-022594-fx044gcd	73	24	main	main	JJ
cord-022594-fx044gcd	73	25	target	target	NN
cord-022594-fx044gcd	73	26	antigens	antigen	NNS
cord-022594-fx044gcd	73	27	are	be	VBP
cord-022594-fx044gcd	73	28	known	know	VBN
cord-022594-fx044gcd	73	29	.	.	.
cord-022594-fx044gcd	74	1	However	however	RB
cord-022594-fx044gcd	74	2	,	,	,
cord-022594-fx044gcd	74	3	despite	despite	IN
cord-022594-fx044gcd	74	4	the	the	DT
cord-022594-fx044gcd	74	5	discovery	discovery	NN
cord-022594-fx044gcd	74	6	of	of	IN
cord-022594-fx044gcd	74	7	several	several	JJ
cord-022594-fx044gcd	74	8	"	"	``
cord-022594-fx044gcd	74	9	weak	weak	JJ
cord-022594-fx044gcd	74	10	"	"	''
cord-022594-fx044gcd	74	11	antigens	antigen	NNS
cord-022594-fx044gcd	74	12	in	in	IN
cord-022594-fx044gcd	74	13	human	human	JJ
cord-022594-fx044gcd	74	14	MS	MS	NNP
cord-022594-fx044gcd	74	15	,	,	,
cord-022594-fx044gcd	74	16	no	no	DT
cord-022594-fx044gcd	74	17	dominant	dominant	JJ
cord-022594-fx044gcd	74	18	antigens	antigen	NNS
cord-022594-fx044gcd	74	19	have	have	VBP
cord-022594-fx044gcd	74	20	been	be	VBN
cord-022594-fx044gcd	74	21	identified	identify	VBN
cord-022594-fx044gcd	74	22	to	to	IN
cord-022594-fx044gcd	74	23	date	date	NN
cord-022594-fx044gcd	74	24	.	.	.
cord-022594-fx044gcd	75	1	The	the	DT
cord-022594-fx044gcd	75	2	only	only	JJ
cord-022594-fx044gcd	75	3	human	human	JJ
cord-022594-fx044gcd	75	4	demyelinating	demyelinating	NN
cord-022594-fx044gcd	75	5	disease	disease	NN
cord-022594-fx044gcd	75	6	with	with	IN
cord-022594-fx044gcd	75	7	an	an	DT
cord-022594-fx044gcd	75	8	identified	identify	VBN
cord-022594-fx044gcd	75	9	specific	specific	JJ
cord-022594-fx044gcd	75	10	antigen	antigen	NN
cord-022594-fx044gcd	75	11	is	be	VBZ
cord-022594-fx044gcd	75	12	Devic	Devic	NNP
cord-022594-fx044gcd	75	13	's	's	POS
cord-022594-fx044gcd	75	14	disease	disease	NN
cord-022594-fx044gcd	75	15	(	(	-LRB-
cord-022594-fx044gcd	75	16	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	75	17	optica	optica	NNP
cord-022594-fx044gcd	75	18	)	)	-RRB-
cord-022594-fx044gcd	75	19	,	,	,
cord-022594-fx044gcd	75	20	which	which	WDT
cord-022594-fx044gcd	75	21	appears	appear	VBZ
cord-022594-fx044gcd	75	22	to	to	TO
cord-022594-fx044gcd	75	23	be	be	VB
cord-022594-fx044gcd	75	24	a	a	DT
cord-022594-fx044gcd	75	25	novel	novel	JJ
cord-022594-fx044gcd	75	26	autoimmune	autoimmune	NN
cord-022594-fx044gcd	75	27	chanellopathy	chanellopathy	JJ
cord-022594-fx044gcd	75	28	with	with	IN
cord-022594-fx044gcd	75	29	an	an	DT
cord-022594-fx044gcd	75	30	antigen	antigen	NN
cord-022594-fx044gcd	75	31	that	that	WDT
cord-022594-fx044gcd	75	32	is	be	VBZ
cord-022594-fx044gcd	75	33	neither	neither	DT
cord-022594-fx044gcd	75	34	neuronal	neuronal	JJ
cord-022594-fx044gcd	75	35	nor	nor	CC
cord-022594-fx044gcd	75	36	myelin	myelin	NN
cord-022594-fx044gcd	75	37	related	relate	VBN
cord-022594-fx044gcd	75	38	(	(	-LRB-
cord-022594-fx044gcd	75	39	see	see	VB
cord-022594-fx044gcd	75	40	later	later	JJ
cord-022594-fx044gcd	75	41	discussion	discussion	NN
cord-022594-fx044gcd	75	42	of	of	IN
cord-022594-fx044gcd	75	43	Devic	Devic	NNP
cord-022594-fx044gcd	75	44	's	's	POS
cord-022594-fx044gcd	75	45	syndrome	syndrome	NN
cord-022594-fx044gcd	75	46	under	under	IN
cord-022594-fx044gcd	75	47	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	75	48	Optica	Optica	NNP
cord-022594-fx044gcd	75	49	)	)	-RRB-
cord-022594-fx044gcd	75	50	.	.	.
cord-022594-fx044gcd	76	1	11	11	CD
cord-022594-fx044gcd	76	2	Infection	infection	NN
cord-022594-fx044gcd	76	3	.	.	.
cord-022594-fx044gcd	77	1	The	the	DT
cord-022594-fx044gcd	77	2	role	role	NN
cord-022594-fx044gcd	77	3	of	of	IN
cord-022594-fx044gcd	77	4	viral	viral	JJ
cord-022594-fx044gcd	77	5	infections	infection	NNS
cord-022594-fx044gcd	77	6	in	in	IN
cord-022594-fx044gcd	77	7	the	the	DT
cord-022594-fx044gcd	77	8	initiation	initiation	NN
cord-022594-fx044gcd	77	9	and	and	CC
cord-022594-fx044gcd	77	10	maintenance	maintenance	NN
cord-022594-fx044gcd	77	11	of	of	IN
cord-022594-fx044gcd	77	12	MS	MS	NNP
cord-022594-fx044gcd	77	13	has	have	VBZ
cord-022594-fx044gcd	77	14	been	be	VBN
cord-022594-fx044gcd	77	15	debated	debate	VBN
cord-022594-fx044gcd	77	16	for	for	IN
cord-022594-fx044gcd	77	17	some	some	DT
cord-022594-fx044gcd	77	18	time	time	NN
cord-022594-fx044gcd	77	19	.	.	.
cord-022594-fx044gcd	78	1	Several	several	JJ
cord-022594-fx044gcd	78	2	viral	viral	JJ
cord-022594-fx044gcd	78	3	infections	infection	NNS
cord-022594-fx044gcd	78	4	are	be	VBP
cord-022594-fx044gcd	78	5	known	know	VBN
cord-022594-fx044gcd	78	6	to	to	TO
cord-022594-fx044gcd	78	7	cause	cause	VB
cord-022594-fx044gcd	78	8	demyelination	demyelination	NN
cord-022594-fx044gcd	78	9	in	in	IN
cord-022594-fx044gcd	78	10	animals	animal	NNS
cord-022594-fx044gcd	78	11	,	,	,
cord-022594-fx044gcd	78	12	including	include	VBG
cord-022594-fx044gcd	78	13	visna	visna	NNP
cord-022594-fx044gcd	78	14	virus	virus	NN
cord-022594-fx044gcd	78	15	of	of	IN
cord-022594-fx044gcd	78	16	goats	goat	NNS
cord-022594-fx044gcd	78	17	and	and	CC
cord-022594-fx044gcd	78	18	sheep	sheep	NNS
cord-022594-fx044gcd	78	19	,	,	,
cord-022594-fx044gcd	78	20	canine	canine	JJ
cord-022594-fx044gcd	78	21	distemper	distemper	NN
cord-022594-fx044gcd	78	22	virus	virus	NN
cord-022594-fx044gcd	78	23	,	,	,
cord-022594-fx044gcd	78	24	and	and	CC
cord-022594-fx044gcd	78	25	Theiler	Theiler	NNP
cord-022594-fx044gcd	78	26	's	's	POS
cord-022594-fx044gcd	78	27	murine	murine	JJ
cord-022594-fx044gcd	78	28	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	78	29	virus	virus	NN
cord-022594-fx044gcd	78	30	.	.	.
cord-022594-fx044gcd	79	1	Viral	viral	JJ
cord-022594-fx044gcd	79	2	infections	infection	NNS
cord-022594-fx044gcd	79	3	in	in	IN
cord-022594-fx044gcd	79	4	humans	human	NNS
cord-022594-fx044gcd	79	5	can	can	MD
cord-022594-fx044gcd	79	6	also	also	RB
cord-022594-fx044gcd	79	7	cause	cause	VB
cord-022594-fx044gcd	79	8	demyelination	demyelination	NN
cord-022594-fx044gcd	79	9	(	(	-LRB-
cord-022594-fx044gcd	79	10	progressive	progressive	JJ
cord-022594-fx044gcd	79	11	multifocal	multifocal	JJ
cord-022594-fx044gcd	79	12	leukoencephalopathy	leukoencephalopathy	NNP
cord-022594-fx044gcd	79	13	[	[	-LRB-
cord-022594-fx044gcd	79	14	JC	JC	NNP
cord-022594-fx044gcd	79	15	papillomavirus	papillomavirus	NN
cord-022594-fx044gcd	79	16	]	]	-RRB-
cord-022594-fx044gcd	79	17	,	,	,
cord-022594-fx044gcd	79	18	subacute	subacute	JJ
cord-022594-fx044gcd	79	19	sclerosing	sclerosing	NN
cord-022594-fx044gcd	79	20	panencephalitis	panencephalitis	NN
cord-022594-fx044gcd	79	21	[	[	-LRB-
cord-022594-fx044gcd	79	22	measles	measles	NNP
cord-022594-fx044gcd	79	23	virus	virus	NN
cord-022594-fx044gcd	79	24	]	]	-RRB-
cord-022594-fx044gcd	79	25	,	,	,
cord-022594-fx044gcd	79	26	and	and	CC
cord-022594-fx044gcd	79	27	human	human	JJ
cord-022594-fx044gcd	79	28	T	t	NN
cord-022594-fx044gcd	79	29	-	-	HYPH
cord-022594-fx044gcd	79	30	cell	cell	NN
cord-022594-fx044gcd	79	31	lymphotropic	lymphotropic	NNP
cord-022594-fx044gcd	79	32	or	or	CC
cord-022594-fx044gcd	79	33	leukemia	leukemia	NN
cord-022594-fx044gcd	79	34	virus	virus	NN
cord-022594-fx044gcd	79	35	type	type	NN
cord-022594-fx044gcd	79	36	1	1	CD
cord-022594-fx044gcd	79	37	[	[	-LRB-
cord-022594-fx044gcd	79	38	HTLV-1]-associated	htlv-1]-associate	VBN
cord-022594-fx044gcd	79	39	myelopathy	myelopathy	NN
cord-022594-fx044gcd	79	40	)	)	-RRB-
cord-022594-fx044gcd	79	41	.	.	.
cord-022594-fx044gcd	80	1	The	the	DT
cord-022594-fx044gcd	80	2	epidemiology	epidemiology	NN
cord-022594-fx044gcd	80	3	of	of	IN
cord-022594-fx044gcd	80	4	MS	MS	NNP
cord-022594-fx044gcd	80	5	suggests	suggest	VBZ
cord-022594-fx044gcd	80	6	that	that	IN
cord-022594-fx044gcd	80	7	environmental	environmental	JJ
cord-022594-fx044gcd	80	8	factors	factor	NNS
cord-022594-fx044gcd	80	9	may	may	MD
cord-022594-fx044gcd	80	10	promote	promote	VB
cord-022594-fx044gcd	80	11	the	the	DT
cord-022594-fx044gcd	80	12	disease	disease	NN
cord-022594-fx044gcd	80	13	state	state	NN
cord-022594-fx044gcd	80	14	,	,	,
cord-022594-fx044gcd	80	15	possibly	possibly	RB
cord-022594-fx044gcd	80	16	due	due	IN
cord-022594-fx044gcd	80	17	to	to	IN
cord-022594-fx044gcd	80	18	one	one	CD
cord-022594-fx044gcd	80	19	or	or	CC
cord-022594-fx044gcd	80	20	more	more	JJR
cord-022594-fx044gcd	80	21	viruses	virus	NNS
cord-022594-fx044gcd	80	22	.	.	.
cord-022594-fx044gcd	81	1	A	a	DT
cord-022594-fx044gcd	81	2	virus	virus	NN
cord-022594-fx044gcd	81	3	may	may	MD
cord-022594-fx044gcd	81	4	be	be	VB
cord-022594-fx044gcd	81	5	involved	involve	VBN
cord-022594-fx044gcd	81	6	in	in	IN
cord-022594-fx044gcd	81	7	the	the	DT
cord-022594-fx044gcd	81	8	pathogenesis	pathogenesis	NN
cord-022594-fx044gcd	81	9	of	of	IN
cord-022594-fx044gcd	81	10	MS	MS	NNP
cord-022594-fx044gcd	81	11	in	in	IN
cord-022594-fx044gcd	81	12	several	several	JJ
cord-022594-fx044gcd	81	13	ways	way	NNS
cord-022594-fx044gcd	81	14	:	:	:
cord-022594-fx044gcd	82	1	1	1	LS
cord-022594-fx044gcd	82	2	.	.	.
cord-022594-fx044gcd	83	1	Transient	transient	JJ
cord-022594-fx044gcd	83	2	or	or	CC
cord-022594-fx044gcd	83	3	persistent	persistent	JJ
cord-022594-fx044gcd	83	4	infection	infection	NN
cord-022594-fx044gcd	83	5	outside	outside	IN
cord-022594-fx044gcd	83	6	the	the	DT
cord-022594-fx044gcd	83	7	CNS	CNS	NNP
cord-022594-fx044gcd	83	8	may	may	MD
cord-022594-fx044gcd	83	9	activate	activate	VB
cord-022594-fx044gcd	83	10	autoreactive	autoreactive	JJ
cord-022594-fx044gcd	83	11	T	t	NN
cord-022594-fx044gcd	83	12	cells	cell	NNS
cord-022594-fx044gcd	83	13	by	by	IN
cord-022594-fx044gcd	83	14	means	mean	NNS
cord-022594-fx044gcd	83	15	of	of	IN
cord-022594-fx044gcd	83	16	molecular	molecular	JJ
cord-022594-fx044gcd	83	17	mimicry	mimicry	NN
cord-022594-fx044gcd	83	18	or	or	CC
cord-022594-fx044gcd	83	19	by	by	IN
cord-022594-fx044gcd	83	20	other	other	JJ
cord-022594-fx044gcd	83	21	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	83	22	means	mean	NNS
cord-022594-fx044gcd	83	23	(	(	-LRB-
cord-022594-fx044gcd	83	24	as	as	IN
cord-022594-fx044gcd	83	25	superantigens	superantigens	NNP
cord-022594-fx044gcd	83	26	do	do	VBP
cord-022594-fx044gcd	83	27	)	)	-RRB-
cord-022594-fx044gcd	83	28	.	.	.
cord-022594-fx044gcd	84	1	2	2	LS
cord-022594-fx044gcd	84	2	.	.	.
cord-022594-fx044gcd	85	1	Transient	transient	JJ
cord-022594-fx044gcd	85	2	CNS	CNS	NNP
cord-022594-fx044gcd	85	3	infection	infection	NN
cord-022594-fx044gcd	85	4	may	may	MD
cord-022594-fx044gcd	85	5	initiate	initiate	VB
cord-022594-fx044gcd	85	6	a	a	DT
cord-022594-fx044gcd	85	7	cascade	cascade	NN
cord-022594-fx044gcd	85	8	of	of	IN
cord-022594-fx044gcd	85	9	events	event	NNS
cord-022594-fx044gcd	85	10	that	that	WDT
cord-022594-fx044gcd	85	11	fosters	foster	VBZ
cord-022594-fx044gcd	85	12	autoimmunity	autoimmunity	NN
cord-022594-fx044gcd	85	13	(	(	-LRB-
cord-022594-fx044gcd	85	14	breach	breach	VB
cord-022594-fx044gcd	85	15	the	the	DT
cord-022594-fx044gcd	85	16	blood	blood	NN
cord-022594-fx044gcd	85	17	-	-	HYPH
cord-022594-fx044gcd	85	18	brain	brain	NN
cord-022594-fx044gcd	85	19	barrier	barrier	NN
cord-022594-fx044gcd	85	20	,	,	,
cord-022594-fx044gcd	85	21	release	release	NN
cord-022594-fx044gcd	85	22	CNS	CNS	NNP
cord-022594-fx044gcd	85	23	antigens	antigen	NNS
cord-022594-fx044gcd	85	24	)	)	-RRB-
cord-022594-fx044gcd	85	25	.	.	.
cord-022594-fx044gcd	86	1	3	3	LS
cord-022594-fx044gcd	86	2	.	.	.
cord-022594-fx044gcd	87	1	Recurrent	recurrent	JJ
cord-022594-fx044gcd	87	2	CNS	CNS	NNP
cord-022594-fx044gcd	87	3	infections	infection	NNS
cord-022594-fx044gcd	87	4	may	may	MD
cord-022594-fx044gcd	87	5	precipitate	precipitate	VB
cord-022594-fx044gcd	87	6	repeated	repeat	VBN
cord-022594-fx044gcd	87	7	inflammation	inflammation	NN
cord-022594-fx044gcd	87	8	and	and	CC
cord-022594-fx044gcd	87	9	demyelination	demyelination	NN
cord-022594-fx044gcd	87	10	.	.	.
cord-022594-fx044gcd	88	1	4	4	LS
cord-022594-fx044gcd	88	2	.	.	.
cord-022594-fx044gcd	89	1	Persistent	persistent	JJ
cord-022594-fx044gcd	89	2	CNS	CNS	NNP
cord-022594-fx044gcd	89	3	viral	viral	JJ
cord-022594-fx044gcd	89	4	infection	infection	NN
cord-022594-fx044gcd	89	5	could	could	MD
cord-022594-fx044gcd	89	6	either	either	CC
cord-022594-fx044gcd	89	7	incite	incite	VB
cord-022594-fx044gcd	89	8	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	89	9	reactions	reaction	NNS
cord-022594-fx044gcd	89	10	detrimental	detrimental	JJ
cord-022594-fx044gcd	89	11	to	to	IN
cord-022594-fx044gcd	89	12	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	89	13	or	or	CC
cord-022594-fx044gcd	89	14	directly	directly	RB
cord-022594-fx044gcd	89	15	injure	injure	VB
cord-022594-fx044gcd	89	16	them	-PRON-	PRP
cord-022594-fx044gcd	89	17	.	.	.
cord-022594-fx044gcd	90	1	Beyond	beyond	IN
cord-022594-fx044gcd	90	2	speculation	speculation	NN
cord-022594-fx044gcd	90	3	and	and	CC
cord-022594-fx044gcd	90	4	epidemiological	epidemiological	JJ
cord-022594-fx044gcd	90	5	observations	observation	NNS
cord-022594-fx044gcd	90	6	,	,	,
cord-022594-fx044gcd	90	7	there	there	EX
cord-022594-fx044gcd	90	8	is	be	VBZ
cord-022594-fx044gcd	90	9	insufficient	insufficient	JJ
cord-022594-fx044gcd	90	10	evidence	evidence	NN
cord-022594-fx044gcd	90	11	for	for	IN
cord-022594-fx044gcd	90	12	a	a	DT
cord-022594-fx044gcd	90	13	viral	viral	JJ
cord-022594-fx044gcd	90	14	infection	infection	NN
cord-022594-fx044gcd	90	15	playing	play	VBG
cord-022594-fx044gcd	90	16	a	a	DT
cord-022594-fx044gcd	90	17	causative	causative	JJ
cord-022594-fx044gcd	90	18	role	role	NN
cord-022594-fx044gcd	90	19	in	in	IN
cord-022594-fx044gcd	90	20	MS	MS	NNP
cord-022594-fx044gcd	90	21	.	.	.
cord-022594-fx044gcd	91	1	Early	early	JJ
cord-022594-fx044gcd	91	2	serological	serological	JJ
cord-022594-fx044gcd	91	3	studies	study	NNS
cord-022594-fx044gcd	91	4	are	be	VBP
cord-022594-fx044gcd	91	5	difficult	difficult	JJ
cord-022594-fx044gcd	91	6	to	to	TO
cord-022594-fx044gcd	91	7	interpret	interpret	VB
cord-022594-fx044gcd	91	8	because	because	IN
cord-022594-fx044gcd	91	9	of	of	IN
cord-022594-fx044gcd	91	10	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	91	11	immune	immune	JJ
cord-022594-fx044gcd	91	12	activation	activation	NN
cord-022594-fx044gcd	91	13	and	and	CC
cord-022594-fx044gcd	91	14	resulting	result	VBG
cord-022594-fx044gcd	91	15	elevation	elevation	NN
cord-022594-fx044gcd	91	16	of	of	IN
cord-022594-fx044gcd	91	17	titers	titer	NNS
cord-022594-fx044gcd	91	18	to	to	IN
cord-022594-fx044gcd	91	19	many	many	JJ
cord-022594-fx044gcd	91	20	different	different	JJ
cord-022594-fx044gcd	91	21	viruses	virus	NNS
cord-022594-fx044gcd	91	22	.	.	.
cord-022594-fx044gcd	92	1	Many	many	JJ
cord-022594-fx044gcd	92	2	MS	MS	NNP
cord-022594-fx044gcd	92	3	patients	patient	NNS
cord-022594-fx044gcd	92	4	have	have	VBP
cord-022594-fx044gcd	92	5	elevated	elevate	VBN
cord-022594-fx044gcd	92	6	cerebrospinal	cerebrospinal	JJ
cord-022594-fx044gcd	92	7	fluid	fluid	NN
cord-022594-fx044gcd	92	8	(	(	-LRB-
cord-022594-fx044gcd	92	9	CSF	csf	NN
cord-022594-fx044gcd	92	10	)	)	-RRB-
cord-022594-fx044gcd	92	11	titers	titer	NNS
cord-022594-fx044gcd	92	12	to	to	IN
cord-022594-fx044gcd	92	13	measles	measle	NNS
cord-022594-fx044gcd	92	14	and	and	CC
cord-022594-fx044gcd	92	15	herpes	herpes	NN
cord-022594-fx044gcd	92	16	simplex	simplex	NN
cord-022594-fx044gcd	92	17	(	(	-LRB-
cord-022594-fx044gcd	92	18	HSV	HSV	NNP
cord-022594-fx044gcd	92	19	)	)	-RRB-
cord-022594-fx044gcd	92	20	viruses	virus	NNS
cord-022594-fx044gcd	92	21	,	,	,
cord-022594-fx044gcd	92	22	but	but	CC
cord-022594-fx044gcd	92	23	this	this	DT
cord-022594-fx044gcd	92	24	finding	finding	NN
cord-022594-fx044gcd	92	25	appears	appear	VBZ
cord-022594-fx044gcd	92	26	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	92	27	.	.	.
cord-022594-fx044gcd	93	1	Virus	virus	NN
cord-022594-fx044gcd	93	2	has	have	VBZ
cord-022594-fx044gcd	93	3	rarely	rarely	RB
cord-022594-fx044gcd	93	4	been	be	VBN
cord-022594-fx044gcd	93	5	cultured	culture	VBN
cord-022594-fx044gcd	93	6	from	from	IN
cord-022594-fx044gcd	93	7	CSF	CSF	NNP
cord-022594-fx044gcd	93	8	of	of	IN
cord-022594-fx044gcd	93	9	MS	MS	NNP
cord-022594-fx044gcd	93	10	patients	patient	NNS
cord-022594-fx044gcd	93	11	,	,	,
cord-022594-fx044gcd	93	12	but	but	CC
cord-022594-fx044gcd	93	13	a	a	DT
cord-022594-fx044gcd	93	14	new	new	JJ
cord-022594-fx044gcd	93	15	strain	strain	NN
cord-022594-fx044gcd	93	16	of	of	IN
cord-022594-fx044gcd	93	17	HSV	HSV	NNP
cord-022594-fx044gcd	93	18	(	(	-LRB-
cord-022594-fx044gcd	93	19	the	the	DT
cord-022594-fx044gcd	93	20	MS	MS	NNP
cord-022594-fx044gcd	93	21	strain	strain	NN
cord-022594-fx044gcd	93	22	)	)	-RRB-
cord-022594-fx044gcd	93	23	and	and	CC
cord-022594-fx044gcd	93	24	a	a	DT
cord-022594-fx044gcd	93	25	new	new	JJ
cord-022594-fx044gcd	93	26	virus	virus	NN
cord-022594-fx044gcd	93	27	(	(	-LRB-
cord-022594-fx044gcd	93	28	Inoue	Inoue	NNP
cord-022594-fx044gcd	93	29	-	-	HYPH
cord-022594-fx044gcd	93	30	Melnick	Melnick	NNP
cord-022594-fx044gcd	93	31	virus	virus	NN
cord-022594-fx044gcd	93	32	)	)	-RRB-
cord-022594-fx044gcd	93	33	were	be	VBD
cord-022594-fx044gcd	93	34	first	first	RB
cord-022594-fx044gcd	93	35	isolated	isolate	VBN
cord-022594-fx044gcd	93	36	from	from	IN
cord-022594-fx044gcd	93	37	the	the	DT
cord-022594-fx044gcd	93	38	CSF	CSF	NNP
cord-022594-fx044gcd	93	39	of	of	IN
cord-022594-fx044gcd	93	40	MS	MS	NNP
cord-022594-fx044gcd	93	41	patients	patient	NNS
cord-022594-fx044gcd	93	42	.	.	.
cord-022594-fx044gcd	94	1	12	12	CD
cord-022594-fx044gcd	94	2	,	,	,
cord-022594-fx044gcd	94	3	13	13	CD
cord-022594-fx044gcd	94	4	Newer	new	JJR
cord-022594-fx044gcd	94	5	molecular	molecular	JJ
cord-022594-fx044gcd	94	6	techniques	technique	NNS
cord-022594-fx044gcd	94	7	to	to	TO
cord-022594-fx044gcd	94	8	search	search	VB
cord-022594-fx044gcd	94	9	for	for	IN
cord-022594-fx044gcd	94	10	a	a	DT
cord-022594-fx044gcd	94	11	viral	viral	JJ
cord-022594-fx044gcd	94	12	genome	genome	NN
cord-022594-fx044gcd	94	13	in	in	IN
cord-022594-fx044gcd	94	14	CSF	CSF	NNP
cord-022594-fx044gcd	94	15	and	and	CC
cord-022594-fx044gcd	94	16	brain	brain	NN
cord-022594-fx044gcd	94	17	have	have	VBP
cord-022594-fx044gcd	94	18	rejected	reject	VBN
cord-022594-fx044gcd	94	19	the	the	DT
cord-022594-fx044gcd	94	20	claim	claim	NN
cord-022594-fx044gcd	94	21	that	that	IN
cord-022594-fx044gcd	94	22	HTLV-1	HTLV-1	NNP
cord-022594-fx044gcd	94	23	is	be	VBZ
cord-022594-fx044gcd	94	24	associated	associate	VBN
cord-022594-fx044gcd	94	25	with	with	IN
cord-022594-fx044gcd	94	26	MS	MS	NNP
cord-022594-fx044gcd	94	27	.	.	.
cord-022594-fx044gcd	95	1	The	the	DT
cord-022594-fx044gcd	95	2	finding	finding	NN
cord-022594-fx044gcd	95	3	that	that	IN
cord-022594-fx044gcd	95	4	human	human	JJ
cord-022594-fx044gcd	95	5	herpesvirus	herpesvirus	NN
cord-022594-fx044gcd	95	6	6	6	CD
cord-022594-fx044gcd	95	7	(	(	-LRB-
cord-022594-fx044gcd	95	8	HHV6	HHV6	NNP
cord-022594-fx044gcd	95	9	)	)	-RRB-
cord-022594-fx044gcd	95	10	,	,	,
cord-022594-fx044gcd	95	11	although	although	IN
cord-022594-fx044gcd	95	12	present	present	JJ
cord-022594-fx044gcd	95	13	in	in	IN
cord-022594-fx044gcd	95	14	70	70	CD
cord-022594-fx044gcd	95	15	%	%	NN
cord-022594-fx044gcd	95	16	of	of	IN
cord-022594-fx044gcd	95	17	brains	brain	NNS
cord-022594-fx044gcd	95	18	from	from	IN
cord-022594-fx044gcd	95	19	both	both	DT
cord-022594-fx044gcd	95	20	control	control	NN
cord-022594-fx044gcd	95	21	subjects	subject	NNS
cord-022594-fx044gcd	95	22	and	and	CC
cord-022594-fx044gcd	95	23	MS	MS	NNP
cord-022594-fx044gcd	95	24	patients	patient	NNS
cord-022594-fx044gcd	95	25	,	,	,
cord-022594-fx044gcd	95	26	is	be	VBZ
cord-022594-fx044gcd	95	27	localized	localize	VBN
cord-022594-fx044gcd	95	28	to	to	IN
cord-022594-fx044gcd	95	29	the	the	DT
cord-022594-fx044gcd	95	30	oligodendrocyte	oligodendrocyte	VBN
cord-022594-fx044gcd	95	31	nuclei	nucleus	NNS
cord-022594-fx044gcd	95	32	near	near	IN
cord-022594-fx044gcd	95	33	plaques	plaque	NNS
cord-022594-fx044gcd	95	34	of	of	IN
cord-022594-fx044gcd	95	35	MS	MS	NNP
cord-022594-fx044gcd	95	36	patients	patient	NNS
cord-022594-fx044gcd	95	37	and	and	CC
cord-022594-fx044gcd	95	38	to	to	IN
cord-022594-fx044gcd	95	39	oligodendrocyte	oligodendrocyte	NNP
cord-022594-fx044gcd	95	40	cytoplasm	cytoplasm	VB
cord-022594-fx044gcd	95	41	in	in	IN
cord-022594-fx044gcd	95	42	control	control	NN
cord-022594-fx044gcd	95	43	subjects	subject	NNS
cord-022594-fx044gcd	95	44	indicates	indicate	VBZ
cord-022594-fx044gcd	95	45	that	that	IN
cord-022594-fx044gcd	95	46	persistent	persistent	JJ
cord-022594-fx044gcd	95	47	CNS	CNS	NNP
cord-022594-fx044gcd	95	48	viral	viral	JJ
cord-022594-fx044gcd	95	49	infection	infection	NN
cord-022594-fx044gcd	95	50	is	be	VBZ
cord-022594-fx044gcd	95	51	common	common	JJ
cord-022594-fx044gcd	95	52	.	.	.
cord-022594-fx044gcd	96	1	14	14	CD
cord-022594-fx044gcd	97	1	This	this	DT
cord-022594-fx044gcd	97	2	raises	raise	VBZ
cord-022594-fx044gcd	97	3	the	the	DT
cord-022594-fx044gcd	97	4	possibility	possibility	NN
cord-022594-fx044gcd	97	5	that	that	IN
cord-022594-fx044gcd	97	6	MS	MS	NNP
cord-022594-fx044gcd	97	7	may	may	MD
cord-022594-fx044gcd	97	8	depend	depend	VB
cord-022594-fx044gcd	97	9	on	on	IN
cord-022594-fx044gcd	97	10	an	an	DT
cord-022594-fx044gcd	97	11	aberrant	aberrant	JJ
cord-022594-fx044gcd	97	12	host	host	NN
cord-022594-fx044gcd	97	13	response	response	NN
cord-022594-fx044gcd	97	14	to	to	IN
cord-022594-fx044gcd	97	15	this	this	DT
cord-022594-fx044gcd	97	16	normal	normal	JJ
cord-022594-fx044gcd	97	17	condition	condition	NN
cord-022594-fx044gcd	97	18	or	or	CC
cord-022594-fx044gcd	97	19	that	that	IN
cord-022594-fx044gcd	97	20	a	a	DT
cord-022594-fx044gcd	97	21	defective	defective	JJ
cord-022594-fx044gcd	97	22	virus	virus	NN
cord-022594-fx044gcd	97	23	that	that	WDT
cord-022594-fx044gcd	97	24	lacks	lack	VBZ
cord-022594-fx044gcd	97	25	the	the	DT
cord-022594-fx044gcd	97	26	ability	ability	NN
cord-022594-fx044gcd	97	27	to	to	TO
cord-022594-fx044gcd	97	28	evade	evade	VB
cord-022594-fx044gcd	97	29	immune	immune	JJ
cord-022594-fx044gcd	97	30	detection	detection	NN
cord-022594-fx044gcd	97	31	may	may	MD
cord-022594-fx044gcd	97	32	be	be	VB
cord-022594-fx044gcd	97	33	to	to	TO
cord-022594-fx044gcd	97	34	blame	blame	VB
cord-022594-fx044gcd	97	35	.	.	.
cord-022594-fx044gcd	98	1	More	more	RBR
cord-022594-fx044gcd	98	2	recently	recently	RB
cord-022594-fx044gcd	98	3	,	,	,
cord-022594-fx044gcd	98	4	measles	measle	NNS
cord-022594-fx044gcd	98	5	and	and	CC
cord-022594-fx044gcd	98	6	canine	canine	JJ
cord-022594-fx044gcd	98	7	distemper	distemper	NN
cord-022594-fx044gcd	98	8	virus	virus	NN
cord-022594-fx044gcd	98	9	antibodies	antibody	NNS
cord-022594-fx044gcd	98	10	were	be	VBD
cord-022594-fx044gcd	98	11	found	find	VBN
cord-022594-fx044gcd	98	12	elevated	elevate	VBN
cord-022594-fx044gcd	98	13	in	in	IN
cord-022594-fx044gcd	98	14	blood	blood	NN
cord-022594-fx044gcd	98	15	and	and	CC
cord-022594-fx044gcd	98	16	CSF	csf	NN
cord-022594-fx044gcd	98	17	samples	sample	NNS
cord-022594-fx044gcd	98	18	of	of	IN
cord-022594-fx044gcd	98	19	MS	MS	NNP
cord-022594-fx044gcd	98	20	patients	patient	NNS
cord-022594-fx044gcd	98	21	,	,	,
cord-022594-fx044gcd	98	22	although	although	IN
cord-022594-fx044gcd	98	23	their	-PRON-	PRP$
cord-022594-fx044gcd	98	24	relationship	relationship	NN
cord-022594-fx044gcd	98	25	is	be	VBZ
cord-022594-fx044gcd	98	26	not	not	RB
cord-022594-fx044gcd	98	27	clear	clear	JJ
cord-022594-fx044gcd	98	28	to	to	IN
cord-022594-fx044gcd	98	29	the	the	DT
cord-022594-fx044gcd	98	30	disease	disease	NN
cord-022594-fx044gcd	98	31	process	process	NN
cord-022594-fx044gcd	98	32	.	.	.
cord-022594-fx044gcd	99	1	In	in	IN
cord-022594-fx044gcd	99	2	a	a	DT
cord-022594-fx044gcd	99	3	study	study	NN
cord-022594-fx044gcd	99	4	from	from	IN
cord-022594-fx044gcd	99	5	Denmark	Denmark	NNP
cord-022594-fx044gcd	99	6	,	,	,
cord-022594-fx044gcd	99	7	patients	patient	NNS
cord-022594-fx044gcd	99	8	with	with	IN
cord-022594-fx044gcd	99	9	serological	serological	JJ
cord-022594-fx044gcd	99	10	markers	marker	NNS
cord-022594-fx044gcd	99	11	for	for	IN
cord-022594-fx044gcd	99	12	late	late	JJ
cord-022594-fx044gcd	99	13	-	-	HYPH
cord-022594-fx044gcd	99	14	stage	stage	NN
cord-022594-fx044gcd	99	15	Epstein	Epstein	NNP
cord-022594-fx044gcd	99	16	-	-	HYPH
cord-022594-fx044gcd	99	17	Barr	Barr	NNP
cord-022594-fx044gcd	99	18	virus	virus	NN
cord-022594-fx044gcd	99	19	(	(	-LRB-
cord-022594-fx044gcd	99	20	EBV	EBV	NNP
cord-022594-fx044gcd	99	21	)	)	-RRB-
cord-022594-fx044gcd	99	22	infection	infection	NN
cord-022594-fx044gcd	99	23	had	have	VBD
cord-022594-fx044gcd	99	24	a	a	DT
cord-022594-fx044gcd	99	25	threefold	threefold	JJ
cord-022594-fx044gcd	99	26	increase	increase	NN
cord-022594-fx044gcd	99	27	in	in	IN
cord-022594-fx044gcd	99	28	the	the	DT
cord-022594-fx044gcd	99	29	likelihood	likelihood	NN
cord-022594-fx044gcd	99	30	of	of	IN
cord-022594-fx044gcd	99	31	developing	develop	VBG
cord-022594-fx044gcd	99	32	MS	MS	NNP
cord-022594-fx044gcd	99	33	.	.	.
cord-022594-fx044gcd	100	1	A	a	DT
cord-022594-fx044gcd	100	2	follow	follow	VB
cord-022594-fx044gcd	100	3	-	-	HYPH
cord-022594-fx044gcd	100	4	up	up	NN
cord-022594-fx044gcd	100	5	study	study	NN
cord-022594-fx044gcd	100	6	from	from	IN
cord-022594-fx044gcd	100	7	Sweden	Sweden	NNP
cord-022594-fx044gcd	100	8	failed	fail	VBD
cord-022594-fx044gcd	100	9	to	to	TO
cord-022594-fx044gcd	100	10	reach	reach	VB
cord-022594-fx044gcd	100	11	this	this	DT
cord-022594-fx044gcd	100	12	conclusion	conclusion	NN
cord-022594-fx044gcd	100	13	.	.	.
cord-022594-fx044gcd	101	1	In	in	IN
cord-022594-fx044gcd	101	2	general	general	JJ
cord-022594-fx044gcd	101	3	,	,	,
cord-022594-fx044gcd	101	4	serum	serum	NN
cord-022594-fx044gcd	101	5	samples	sample	NNS
cord-022594-fx044gcd	101	6	of	of	IN
cord-022594-fx044gcd	101	7	MS	MS	NNP
cord-022594-fx044gcd	101	8	patients	patient	NNS
cord-022594-fx044gcd	101	9	may	may	MD
cord-022594-fx044gcd	101	10	contain	contain	VB
cord-022594-fx044gcd	101	11	higher	high	JJR
cord-022594-fx044gcd	101	12	titers	titer	NNS
cord-022594-fx044gcd	101	13	of	of	IN
cord-022594-fx044gcd	101	14	antibodies	antibody	NNS
cord-022594-fx044gcd	101	15	to	to	IN
cord-022594-fx044gcd	101	16	the	the	DT
cord-022594-fx044gcd	101	17	following	follow	VBG
cord-022594-fx044gcd	101	18	infectious	infectious	JJ
cord-022594-fx044gcd	101	19	organisms	organism	NNS
cord-022594-fx044gcd	101	20	:	:	:
cord-022594-fx044gcd	101	21	adenovirus	adenovirus	NN
cord-022594-fx044gcd	101	22	,	,	,
cord-022594-fx044gcd	101	23	canine	canine	JJ
cord-022594-fx044gcd	101	24	distemper	distemper	NN
cord-022594-fx044gcd	101	25	virus	virus	NN
cord-022594-fx044gcd	101	26	,	,	,
cord-022594-fx044gcd	101	27	HSV	HSV	NNP
cord-022594-fx044gcd	101	28	,	,	,
cord-022594-fx044gcd	101	29	HHV6	HHV6	NNP
cord-022594-fx044gcd	101	30	,	,	,
cord-022594-fx044gcd	101	31	and	and	CC
cord-022594-fx044gcd	101	32	influenza	influenza	NN
cord-022594-fx044gcd	101	33	,	,	,
cord-022594-fx044gcd	101	34	measles	measle	NNS
cord-022594-fx044gcd	101	35	,	,	,
cord-022594-fx044gcd	101	36	mumps	mumps	NN
cord-022594-fx044gcd	101	37	,	,	,
cord-022594-fx044gcd	101	38	parainfluenza	parainfluenza	NNP
cord-022594-fx044gcd	101	39	,	,	,
cord-022594-fx044gcd	101	40	rubella	rubella	NN
cord-022594-fx044gcd	101	41	,	,	,
cord-022594-fx044gcd	101	42	vaccinia	vaccinia	NN
cord-022594-fx044gcd	101	43	,	,	,
cord-022594-fx044gcd	101	44	and	and	CC
cord-022594-fx044gcd	101	45	varicella	varicella	NN
cord-022594-fx044gcd	101	46	zoster	zoster	NN
cord-022594-fx044gcd	101	47	virus	virus	NN
cord-022594-fx044gcd	101	48	(	(	-LRB-
cord-022594-fx044gcd	101	49	VZV	VZV	NNP
cord-022594-fx044gcd	101	50	)	)	-RRB-
cord-022594-fx044gcd	101	51	.	.	.
cord-022594-fx044gcd	102	1	Similarly	similarly	RB
cord-022594-fx044gcd	102	2	,	,	,
cord-022594-fx044gcd	102	3	CSF	CSF	NNP
cord-022594-fx044gcd	102	4	samples	sample	NNS
cord-022594-fx044gcd	102	5	from	from	IN
cord-022594-fx044gcd	102	6	MS	MS	NNP
cord-022594-fx044gcd	102	7	patients	patient	NNS
cord-022594-fx044gcd	102	8	may	may	MD
cord-022594-fx044gcd	102	9	show	show	VB
cord-022594-fx044gcd	102	10	higher	high	JJR
cord-022594-fx044gcd	102	11	titers	titer	NNS
cord-022594-fx044gcd	102	12	of	of	IN
cord-022594-fx044gcd	102	13	adenovirus	adenovirus	NN
cord-022594-fx044gcd	102	14	;	;	:
cord-022594-fx044gcd	102	15	Chlamydia	Chlamydia	NNP
cord-022594-fx044gcd	102	16	pneumoniae	pneumoniae	NN
cord-022594-fx044gcd	102	17	;	;	:
cord-022594-fx044gcd	102	18	cytomegalovirus	cytomegalovirus	NNP
cord-022594-fx044gcd	102	19	(	(	-LRB-
cord-022594-fx044gcd	102	20	CMV	CMV	NNP
cord-022594-fx044gcd	102	21	)	)	-RRB-
cord-022594-fx044gcd	102	22	;	;	:
cord-022594-fx044gcd	102	23	EBV	EBV	NNP
cord-022594-fx044gcd	102	24	;	;	:
cord-022594-fx044gcd	102	25	HHV6	HHV6	NNP
cord-022594-fx044gcd	102	26	;	;	:
cord-022594-fx044gcd	102	27	coronavirus	coronavirus	NN
cord-022594-fx044gcd	102	28	;	;	,
cord-022594-fx044gcd	102	29	influenza	influenza	NN
cord-022594-fx044gcd	102	30	viruses	viruse	VBZ
cord-022594-fx044gcd	102	31	A	A	NNP
cord-022594-fx044gcd	102	32	and	and	CC
cord-022594-fx044gcd	102	33	B	b	NN
cord-022594-fx044gcd	102	34	;	;	:
cord-022594-fx044gcd	102	35	measles	measle	NNS
cord-022594-fx044gcd	102	36	or	or	CC
cord-022594-fx044gcd	102	37	mumps	mumps	NN
cord-022594-fx044gcd	102	38	virus	virus	NN
cord-022594-fx044gcd	102	39	;	;	:
cord-022594-fx044gcd	102	40	Mycoplasma	mycoplasma	NN
cord-022594-fx044gcd	102	41	pneumoniae	pneumoniae	NNS
cord-022594-fx044gcd	102	42	;	;	:
cord-022594-fx044gcd	102	43	parainfluenza	parainfluenza	NNP
cord-022594-fx044gcd	102	44	viruses	virus	NNS
cord-022594-fx044gcd	102	45	1	1	CD
cord-022594-fx044gcd	102	46	,	,	,
cord-022594-fx044gcd	102	47	2	2	CD
cord-022594-fx044gcd	102	48	,	,	,
cord-022594-fx044gcd	102	49	and	and	CC
cord-022594-fx044gcd	102	50	3	3	CD
cord-022594-fx044gcd	102	51	;	;	,
cord-022594-fx044gcd	102	52	respiratory	respiratory	JJ
cord-022594-fx044gcd	102	53	syncytial	syncytial	JJ
cord-022594-fx044gcd	102	54	virus	virus	NN
cord-022594-fx044gcd	102	55	;	;	:
cord-022594-fx044gcd	102	56	rubella	rubella	NN
cord-022594-fx044gcd	102	57	virus	virus	NN
cord-022594-fx044gcd	102	58	;	;	:
cord-022594-fx044gcd	102	59	vaccinia	vaccinia	NN
cord-022594-fx044gcd	102	60	;	;	:
cord-022594-fx044gcd	102	61	and	and	CC
cord-022594-fx044gcd	102	62	VZV	VZV	NNP
cord-022594-fx044gcd	102	63	.	.	.
cord-022594-fx044gcd	103	1	There	there	EX
cord-022594-fx044gcd	103	2	has	have	VBZ
cord-022594-fx044gcd	103	3	been	be	VBN
cord-022594-fx044gcd	103	4	an	an	DT
cord-022594-fx044gcd	103	5	interest	interest	NN
cord-022594-fx044gcd	103	6	recently	recently	RB
cord-022594-fx044gcd	103	7	in	in	IN
cord-022594-fx044gcd	103	8	a	a	DT
cord-022594-fx044gcd	103	9	potential	potential	JJ
cord-022594-fx044gcd	103	10	link	link	NN
cord-022594-fx044gcd	103	11	between	between	IN
cord-022594-fx044gcd	103	12	C.	C.	NNP
cord-022594-fx044gcd	103	13	pneumoniae	pneumoniae	NN
cord-022594-fx044gcd	103	14	infection	infection	NN
cord-022594-fx044gcd	103	15	and	and	CC
cord-022594-fx044gcd	103	16	the	the	DT
cord-022594-fx044gcd	103	17	development	development	NN
cord-022594-fx044gcd	103	18	of	of	IN
cord-022594-fx044gcd	103	19	MS	MS	NNP
cord-022594-fx044gcd	103	20	.	.	.
cord-022594-fx044gcd	104	1	No	no	DT
cord-022594-fx044gcd	104	2	direct	direct	JJ
cord-022594-fx044gcd	104	3	cause	cause	NN
cord-022594-fx044gcd	104	4	-	-	HYPH
cord-022594-fx044gcd	104	5	and	and	CC
cord-022594-fx044gcd	104	6	-	-	HYPH
cord-022594-fx044gcd	104	7	effect	effect	NN
cord-022594-fx044gcd	104	8	relationship	relationship	NN
cord-022594-fx044gcd	104	9	has	have	VBZ
cord-022594-fx044gcd	104	10	been	be	VBN
cord-022594-fx044gcd	104	11	observed	observe	VBN
cord-022594-fx044gcd	104	12	between	between	IN
cord-022594-fx044gcd	104	13	any	any	DT
cord-022594-fx044gcd	104	14	of	of	IN
cord-022594-fx044gcd	104	15	these	these	DT
cord-022594-fx044gcd	104	16	infections	infection	NNS
cord-022594-fx044gcd	104	17	and	and	CC
cord-022594-fx044gcd	104	18	MS	MS	NNP
cord-022594-fx044gcd	104	19	.	.	.
cord-022594-fx044gcd	105	1	"	"	``
cord-022594-fx044gcd	105	2	Bystander	bystander	NN
cord-022594-fx044gcd	105	3	"	"	''
cord-022594-fx044gcd	105	4	Demyelination	Demyelination	NNP
cord-022594-fx044gcd	105	5	.	.	.
cord-022594-fx044gcd	106	1	Immune	immune	JJ
cord-022594-fx044gcd	106	2	actions	action	NNS
cord-022594-fx044gcd	106	3	may	may	MD
cord-022594-fx044gcd	106	4	mediate	mediate	VB
cord-022594-fx044gcd	106	5	myelin	myelin	JJ
cord-022594-fx044gcd	106	6	injury	injury	NN
cord-022594-fx044gcd	106	7	in	in	IN
cord-022594-fx044gcd	106	8	a	a	DT
cord-022594-fx044gcd	106	9	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	106	10	manner	manner	NN
cord-022594-fx044gcd	106	11	.	.	.
cord-022594-fx044gcd	107	1	Many	many	JJ
cord-022594-fx044gcd	107	2	soluble	soluble	JJ
cord-022594-fx044gcd	107	3	products	product	NNS
cord-022594-fx044gcd	107	4	of	of	IN
cord-022594-fx044gcd	107	5	the	the	DT
cord-022594-fx044gcd	107	6	immune	immune	JJ
cord-022594-fx044gcd	107	7	response	response	NN
cord-022594-fx044gcd	107	8	other	other	JJ
cord-022594-fx044gcd	107	9	than	than	IN
cord-022594-fx044gcd	107	10	immunoglobulins	immunoglobulin	NNS
cord-022594-fx044gcd	107	11	are	be	VBP
cord-022594-fx044gcd	107	12	known	know	VBN
cord-022594-fx044gcd	107	13	or	or	CC
cord-022594-fx044gcd	107	14	suspected	suspect	VBN
cord-022594-fx044gcd	107	15	to	to	TO
cord-022594-fx044gcd	107	16	be	be	VB
cord-022594-fx044gcd	107	17	toxic	toxic	JJ
cord-022594-fx044gcd	107	18	to	to	IN
cord-022594-fx044gcd	107	19	myelin	myelin	NN
cord-022594-fx044gcd	107	20	and	and	CC
cord-022594-fx044gcd	107	21	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	107	22	.	.	.
cord-022594-fx044gcd	108	1	Activated	activate	VBN
cord-022594-fx044gcd	108	2	complement	complement	NN
cord-022594-fx044gcd	108	3	is	be	VBZ
cord-022594-fx044gcd	108	4	capable	capable	JJ
cord-022594-fx044gcd	108	5	of	of	IN
cord-022594-fx044gcd	108	6	lysing	lyse	VBG
cord-022594-fx044gcd	108	7	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	108	8	in	in	IN
cord-022594-fx044gcd	108	9	an	an	DT
cord-022594-fx044gcd	108	10	antibody	antibody	NN
cord-022594-fx044gcd	108	11	-	-	HYPH
cord-022594-fx044gcd	108	12	independent	independent	JJ
cord-022594-fx044gcd	108	13	fashion	fashion	NN
cord-022594-fx044gcd	108	14	.	.	.
cord-022594-fx044gcd	109	1	15	15	CD
cord-022594-fx044gcd	110	1	The	the	DT
cord-022594-fx044gcd	110	2	proinflammatory	proinflammatory	JJ
cord-022594-fx044gcd	110	3	cytokine	cytokine	NN
cord-022594-fx044gcd	110	4	tumor	tumor	NN
cord-022594-fx044gcd	110	5	necrosis	necrosis	NN
cord-022594-fx044gcd	110	6	factor	factor	NN
cord-022594-fx044gcd	110	7	-	-	:
cord-022594-fx044gcd	110	8	a	a	DT
cord-022594-fx044gcd	110	9	causes	cause	VBZ
cord-022594-fx044gcd	110	10	myelin	myelin	NN
cord-022594-fx044gcd	110	11	disruption	disruption	NN
cord-022594-fx044gcd	110	12	and	and	CC
cord-022594-fx044gcd	110	13	oligodendrocyte	oligodendrocyte	VBN
cord-022594-fx044gcd	110	14	apoptosis	apoptosis	NN
cord-022594-fx044gcd	110	15	in	in	IN
cord-022594-fx044gcd	110	16	vitro	vitro	FW
cord-022594-fx044gcd	110	17	.	.	.
cord-022594-fx044gcd	111	1	16	16	CD
cord-022594-fx044gcd	111	2	Arachidonic	arachidonic	JJ
cord-022594-fx044gcd	111	3	acid	acid	NN
cord-022594-fx044gcd	111	4	metabolites	metabolite	NNS
cord-022594-fx044gcd	111	5	may	may	MD
cord-022594-fx044gcd	111	6	also	also	RB
cord-022594-fx044gcd	111	7	participate	participate	VB
cord-022594-fx044gcd	111	8	in	in	IN
cord-022594-fx044gcd	111	9	myelinolysis	myelinolysis	NNP
cord-022594-fx044gcd	111	10	,	,	,
cord-022594-fx044gcd	111	11	and	and	CC
cord-022594-fx044gcd	111	12	reactive	reactive	JJ
cord-022594-fx044gcd	111	13	oxygen	oxygen	NN
cord-022594-fx044gcd	111	14	species	specie	NNS
cord-022594-fx044gcd	111	15	released	release	VBN
cord-022594-fx044gcd	111	16	by	by	IN
cord-022594-fx044gcd	111	17	macrophages	macrophage	NNS
cord-022594-fx044gcd	111	18	cause	cause	VBP
cord-022594-fx044gcd	111	19	lipid	lipid	NN
cord-022594-fx044gcd	111	20	peroxidation	peroxidation	NN
cord-022594-fx044gcd	111	21	that	that	WDT
cord-022594-fx044gcd	111	22	can	can	MD
cord-022594-fx044gcd	111	23	damage	damage	VB
cord-022594-fx044gcd	111	24	myelin	myelin	NN
cord-022594-fx044gcd	111	25	.	.	.
cord-022594-fx044gcd	112	1	Other	other	JJ
cord-022594-fx044gcd	112	2	soluble	soluble	JJ
cord-022594-fx044gcd	112	3	substances	substance	NNS
cord-022594-fx044gcd	112	4	that	that	WDT
cord-022594-fx044gcd	112	5	are	be	VBP
cord-022594-fx044gcd	112	6	potentially	potentially	RB
cord-022594-fx044gcd	112	7	toxic	toxic	JJ
cord-022594-fx044gcd	112	8	to	to	IN
cord-022594-fx044gcd	112	9	myelin	myelin	NN
cord-022594-fx044gcd	112	10	include	include	VBP
cord-022594-fx044gcd	112	11	nitric	nitric	NN
cord-022594-fx044gcd	112	12	oxide	oxide	NN
cord-022594-fx044gcd	112	13	and	and	CC
cord-022594-fx044gcd	112	14	vasoactive	vasoactive	JJ
cord-022594-fx044gcd	112	15	amines	amine	NNS
cord-022594-fx044gcd	112	16	.	.	.
cord-022594-fx044gcd	113	1	Histological	Histological	NNP
cord-022594-fx044gcd	113	2	Subtypes	Subtypes	NNPS
cord-022594-fx044gcd	113	3	of	of	IN
cord-022594-fx044gcd	113	4	MS	MS	NNP
cord-022594-fx044gcd	113	5	Lesion	Lesion	NNP
cord-022594-fx044gcd	113	6	Development	Development	NNP
cord-022594-fx044gcd	113	7	.	.	.
cord-022594-fx044gcd	114	1	Through	through	IN
cord-022594-fx044gcd	114	2	the	the	DT
cord-022594-fx044gcd	114	3	groundbreaking	groundbreaking	JJ
cord-022594-fx044gcd	114	4	work	work	NN
cord-022594-fx044gcd	114	5	of	of	IN
cord-022594-fx044gcd	114	6	Lucchinetti	Lucchinetti	NNP
cord-022594-fx044gcd	114	7	and	and	CC
cord-022594-fx044gcd	114	8	associates	associate	NNS
cord-022594-fx044gcd	114	9	in	in	IN
cord-022594-fx044gcd	114	10	the	the	DT
cord-022594-fx044gcd	114	11	MS	MS	NNP
cord-022594-fx044gcd	114	12	lesion	lesion	NN
cord-022594-fx044gcd	114	13	project	project	NN
cord-022594-fx044gcd	114	14	,	,	,
cord-022594-fx044gcd	114	15	it	-PRON-	PRP
cord-022594-fx044gcd	114	16	is	be	VBZ
cord-022594-fx044gcd	114	17	postulated	postulate	VBN
cord-022594-fx044gcd	114	18	that	that	IN
cord-022594-fx044gcd	114	19	the	the	DT
cord-022594-fx044gcd	114	20	formation	formation	NN
cord-022594-fx044gcd	114	21	of	of	IN
cord-022594-fx044gcd	114	22	MS	MS	NNP
cord-022594-fx044gcd	114	23	lesions	lesion	NNS
cord-022594-fx044gcd	114	24	follows	follow	VBZ
cord-022594-fx044gcd	114	25	one	one	CD
cord-022594-fx044gcd	114	26	of	of	IN
cord-022594-fx044gcd	114	27	four	four	CD
cord-022594-fx044gcd	114	28	patterns	pattern	NNS
cord-022594-fx044gcd	114	29	.	.	.
cord-022594-fx044gcd	115	1	17	17	CD
cord-022594-fx044gcd	115	2	Patterns	pattern	NNS
cord-022594-fx044gcd	115	3	I	-PRON-	PRP
cord-022594-fx044gcd	115	4	and	and	CC
cord-022594-fx044gcd	115	5	II	II	NNP
cord-022594-fx044gcd	115	6	are	be	VBP
cord-022594-fx044gcd	115	7	related	relate	VBN
cord-022594-fx044gcd	115	8	to	to	IN
cord-022594-fx044gcd	115	9	immune	immune	NN
cord-022594-fx044gcd	115	10	-	-	HYPH
cord-022594-fx044gcd	115	11	mediated	mediate	VBN
cord-022594-fx044gcd	115	12	damage	damage	NN
cord-022594-fx044gcd	115	13	to	to	IN
cord-022594-fx044gcd	115	14	myelin	myelin	NN
cord-022594-fx044gcd	115	15	sheaths	sheath	NNS
cord-022594-fx044gcd	115	16	.	.	.
cord-022594-fx044gcd	116	1	In	in	IN
cord-022594-fx044gcd	116	2	pattern	pattern	NN
cord-022594-fx044gcd	116	3	I	-PRON-	PRP
cord-022594-fx044gcd	116	4	,	,	,
cord-022594-fx044gcd	116	5	cellular	cellular	JJ
cord-022594-fx044gcd	116	6	mechanisms	mechanism	NNS
cord-022594-fx044gcd	116	7	of	of	IN
cord-022594-fx044gcd	116	8	injury	injury	NN
cord-022594-fx044gcd	116	9	seem	seem	VBP
cord-022594-fx044gcd	116	10	to	to	TO
cord-022594-fx044gcd	116	11	prevail	prevail	VB
cord-022594-fx044gcd	116	12	(	(	-LRB-
cord-022594-fx044gcd	116	13	macrophages	macrophage	NNS
cord-022594-fx044gcd	116	14	and	and	CC
cord-022594-fx044gcd	116	15	T	t	NN
cord-022594-fx044gcd	116	16	-	-	HYPH
cord-022594-fx044gcd	116	17	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	116	18	)	)	-RRB-
cord-022594-fx044gcd	117	1	whereas	whereas	IN
cord-022594-fx044gcd	117	2	in	in	IN
cord-022594-fx044gcd	117	3	pattern	pattern	NN
cord-022594-fx044gcd	117	4	II	ii	CD
cord-022594-fx044gcd	117	5	humoral	humoral	JJ
cord-022594-fx044gcd	117	6	mechanisms	mechanism	NNS
cord-022594-fx044gcd	117	7	of	of	IN
cord-022594-fx044gcd	117	8	injury	injury	NN
cord-022594-fx044gcd	117	9	predominate	predominate	NNS
cord-022594-fx044gcd	117	10	(	(	-LRB-
cord-022594-fx044gcd	117	11	e.g.	e.g.	RB
cord-022594-fx044gcd	117	12	,	,	,
cord-022594-fx044gcd	117	13	antibody	antibody	NN
cord-022594-fx044gcd	117	14	and	and	CC
cord-022594-fx044gcd	117	15	complement	complement	NN
cord-022594-fx044gcd	117	16	-	-	HYPH
cord-022594-fx044gcd	117	17	mediated	mediate	VBN
cord-022594-fx044gcd	117	18	mechanisms	mechanism	NNS
cord-022594-fx044gcd	117	19	)	)	-RRB-
cord-022594-fx044gcd	117	20	.	.	.
cord-022594-fx044gcd	118	1	Patterns	pattern	NNS
cord-022594-fx044gcd	118	2	III	III	NNP
cord-022594-fx044gcd	118	3	and	and	CC
cord-022594-fx044gcd	118	4	IV	IV	NNP
cord-022594-fx044gcd	118	5	are	be	VBP
cord-022594-fx044gcd	118	6	related	relate	VBN
cord-022594-fx044gcd	118	7	to	to	IN
cord-022594-fx044gcd	118	8	oligondendrocye	oligondendrocye	FW
cord-022594-fx044gcd	118	9	pathology	pathology	NN
cord-022594-fx044gcd	118	10	:	:	:
cord-022594-fx044gcd	119	1	in	in	IN
cord-022594-fx044gcd	119	2	pattern	pattern	NN
cord-022594-fx044gcd	119	3	III	III	NNP
cord-022594-fx044gcd	119	4	,	,	,
cord-022594-fx044gcd	119	5	a	a	DT
cord-022594-fx044gcd	119	6	distal	distal	JJ
cord-022594-fx044gcd	119	7	oligdendrogliopathy	oligdendrogliopathy	NN
cord-022594-fx044gcd	119	8	and	and	CC
cord-022594-fx044gcd	119	9	apoptosis	apoptosis	NN
cord-022594-fx044gcd	119	10	have	have	VBP
cord-022594-fx044gcd	119	11	been	be	VBN
cord-022594-fx044gcd	119	12	reported	report	VBN
cord-022594-fx044gcd	119	13	,	,	,
cord-022594-fx044gcd	119	14	whereas	whereas	IN
cord-022594-fx044gcd	119	15	in	in	IN
cord-022594-fx044gcd	119	16	pattern	pattern	NN
cord-022594-fx044gcd	119	17	IV	IV	NNP
cord-022594-fx044gcd	119	18	,	,	,
cord-022594-fx044gcd	119	19	primary	primary	JJ
cord-022594-fx044gcd	119	20	oligodendrogliopathy	oligodendrogliopathy	NN
cord-022594-fx044gcd	119	21	and	and	CC
cord-022594-fx044gcd	119	22	degeneration	degeneration	NN
cord-022594-fx044gcd	119	23	of	of	IN
cord-022594-fx044gcd	119	24	oligodendrocytes	oligodendrocyte	NNS
cord-022594-fx044gcd	119	25	have	have	VBP
cord-022594-fx044gcd	119	26	been	be	VBN
cord-022594-fx044gcd	119	27	described	describe	VBN
cord-022594-fx044gcd	119	28	.	.	.
cord-022594-fx044gcd	120	1	Currently	currently	RB
cord-022594-fx044gcd	120	2	these	these	DT
cord-022594-fx044gcd	120	3	subtypes	subtype	NNS
cord-022594-fx044gcd	120	4	can	can	MD
cord-022594-fx044gcd	120	5	be	be	VB
cord-022594-fx044gcd	120	6	diagnosed	diagnose	VBN
cord-022594-fx044gcd	120	7	only	only	RB
cord-022594-fx044gcd	120	8	by	by	IN
cord-022594-fx044gcd	120	9	biopsy	biopsy	NN
cord-022594-fx044gcd	120	10	;	;	:
cord-022594-fx044gcd	120	11	serum	serum	NN
cord-022594-fx044gcd	120	12	and	and	CC
cord-022594-fx044gcd	120	13	magnetic	magnetic	JJ
cord-022594-fx044gcd	120	14	resonance	resonance	NN
cord-022594-fx044gcd	120	15	imaging	imaging	NN
cord-022594-fx044gcd	120	16	(	(	-LRB-
cord-022594-fx044gcd	120	17	MRI	MRI	NNP
cord-022594-fx044gcd	120	18	)	)	-RRB-
cord-022594-fx044gcd	120	19	markers	marker	NNS
cord-022594-fx044gcd	120	20	are	be	VBP
cord-022594-fx044gcd	120	21	not	not	RB
cord-022594-fx044gcd	120	22	yet	yet	RB
cord-022594-fx044gcd	120	23	known	know	VBN
cord-022594-fx044gcd	120	24	,	,	,
cord-022594-fx044gcd	120	25	although	although	IN
cord-022594-fx044gcd	120	26	lesional	lesional	NNP
cord-022594-fx044gcd	120	27	T2	T2	NNP
cord-022594-fx044gcd	120	28	hypointense	hypointense	NN
cord-022594-fx044gcd	120	29	rims	rim	NNS
cord-022594-fx044gcd	120	30	and	and	CC
cord-022594-fx044gcd	120	31	response	response	NN
cord-022594-fx044gcd	120	32	to	to	IN
cord-022594-fx044gcd	120	33	plasma	plasma	NN
cord-022594-fx044gcd	120	34	exchange	exchange	NN
cord-022594-fx044gcd	120	35	may	may	MD
cord-022594-fx044gcd	120	36	correlate	correlate	VB
cord-022594-fx044gcd	120	37	well	well	RB
cord-022594-fx044gcd	120	38	with	with	IN
cord-022594-fx044gcd	120	39	pattern	pattern	NN
cord-022594-fx044gcd	120	40	II	ii	CD
cord-022594-fx044gcd	120	41	pathology	pathology	NN
cord-022594-fx044gcd	120	42	.	.	.
cord-022594-fx044gcd	121	1	It	-PRON-	PRP
cord-022594-fx044gcd	121	2	is	be	VBZ
cord-022594-fx044gcd	121	3	important	important	JJ
cord-022594-fx044gcd	121	4	to	to	TO
cord-022594-fx044gcd	121	5	note	note	VB
cord-022594-fx044gcd	121	6	that	that	IN
cord-022594-fx044gcd	121	7	the	the	DT
cord-022594-fx044gcd	121	8	patterns	pattern	NNS
cord-022594-fx044gcd	121	9	do	do	VBP
cord-022594-fx044gcd	121	10	not	not	RB
cord-022594-fx044gcd	121	11	correlate	correlate	VB
cord-022594-fx044gcd	121	12	with	with	IN
cord-022594-fx044gcd	121	13	clinical	clinical	JJ
cord-022594-fx044gcd	121	14	subtypes	subtype	NNS
cord-022594-fx044gcd	121	15	of	of	IN
cord-022594-fx044gcd	121	16	MS	MS	NNP
cord-022594-fx044gcd	121	17	,	,	,
cord-022594-fx044gcd	121	18	with	with	IN
cord-022594-fx044gcd	121	19	the	the	DT
cord-022594-fx044gcd	121	20	exception	exception	NN
cord-022594-fx044gcd	121	21	of	of	IN
cord-022594-fx044gcd	121	22	pattern	pattern	NN
cord-022594-fx044gcd	121	23	IV	IV	NNP
cord-022594-fx044gcd	121	24	,	,	,
cord-022594-fx044gcd	121	25	which	which	WDT
cord-022594-fx044gcd	121	26	has	have	VBZ
cord-022594-fx044gcd	121	27	been	be	VBN
cord-022594-fx044gcd	121	28	identified	identify	VBN
cord-022594-fx044gcd	121	29	only	only	RB
cord-022594-fx044gcd	121	30	in	in	IN
cord-022594-fx044gcd	121	31	primary	primary	JJ
cord-022594-fx044gcd	121	32	progressive	progressive	JJ
cord-022594-fx044gcd	121	33	(	(	-LRB-
cord-022594-fx044gcd	121	34	PPMS	PPMS	NNP
cord-022594-fx044gcd	121	35	)	)	-RRB-
cord-022594-fx044gcd	121	36	patients	patient	NNS
cord-022594-fx044gcd	121	37	.	.	.
cord-022594-fx044gcd	122	1	Evidence	evidence	NN
cord-022594-fx044gcd	122	2	to	to	IN
cord-022594-fx044gcd	122	3	date	date	NN
cord-022594-fx044gcd	122	4	suggests	suggest	VBZ
cord-022594-fx044gcd	122	5	that	that	IN
cord-022594-fx044gcd	122	6	the	the	DT
cord-022594-fx044gcd	122	7	pattern	pattern	NN
cord-022594-fx044gcd	122	8	of	of	IN
cord-022594-fx044gcd	122	9	lesion	lesion	NN
cord-022594-fx044gcd	122	10	formation	formation	NN
cord-022594-fx044gcd	122	11	remains	remain	VBZ
cord-022594-fx044gcd	122	12	the	the	DT
cord-022594-fx044gcd	122	13	same	same	JJ
cord-022594-fx044gcd	122	14	within	within	IN
cord-022594-fx044gcd	122	15	an	an	DT
cord-022594-fx044gcd	122	16	individual	individual	JJ
cord-022594-fx044gcd	122	17	patient	patient	NN
cord-022594-fx044gcd	122	18	;	;	:
cord-022594-fx044gcd	122	19	patients	patient	NNS
cord-022594-fx044gcd	122	20	do	do	VBP
cord-022594-fx044gcd	122	21	not	not	RB
cord-022594-fx044gcd	122	22	"	"	``
cord-022594-fx044gcd	122	23	switch	switch	VB
cord-022594-fx044gcd	122	24	"	"	''
cord-022594-fx044gcd	122	25	from	from	IN
cord-022594-fx044gcd	122	26	one	one	CD
cord-022594-fx044gcd	122	27	pattern	pattern	NN
cord-022594-fx044gcd	122	28	to	to	IN
cord-022594-fx044gcd	122	29	the	the	DT
cord-022594-fx044gcd	122	30	other	other	JJ
cord-022594-fx044gcd	122	31	.	.	.
cord-022594-fx044gcd	123	1	Also	also	RB
cord-022594-fx044gcd	123	2	,	,	,
cord-022594-fx044gcd	123	3	the	the	DT
cord-022594-fx044gcd	123	4	patterns	pattern	NNS
cord-022594-fx044gcd	123	5	do	do	VBP
cord-022594-fx044gcd	123	6	not	not	RB
cord-022594-fx044gcd	123	7	seem	seem	VB
cord-022594-fx044gcd	123	8	to	to	TO
cord-022594-fx044gcd	123	9	represent	represent	VB
cord-022594-fx044gcd	123	10	different	different	JJ
cord-022594-fx044gcd	123	11	chronological	chronological	JJ
cord-022594-fx044gcd	123	12	stages	stage	NNS
cord-022594-fx044gcd	123	13	of	of	IN
cord-022594-fx044gcd	123	14	lesion	lesion	NN
cord-022594-fx044gcd	123	15	formation	formation	NN
cord-022594-fx044gcd	123	16	.	.	.
cord-022594-fx044gcd	124	1	Gray	Gray	NNP
cord-022594-fx044gcd	124	2	Matter	Matter	NNP
cord-022594-fx044gcd	124	3	Involvement	Involvement	NNP
cord-022594-fx044gcd	124	4	.	.	.
cord-022594-fx044gcd	125	1	It	-PRON-	PRP
cord-022594-fx044gcd	125	2	has	have	VBZ
cord-022594-fx044gcd	125	3	been	be	VBN
cord-022594-fx044gcd	125	4	known	know	VBN
cord-022594-fx044gcd	125	5	since	since	IN
cord-022594-fx044gcd	125	6	the	the	DT
cord-022594-fx044gcd	125	7	late	late	JJ
cord-022594-fx044gcd	125	8	19th	19th	JJ
cord-022594-fx044gcd	125	9	century	century	NN
cord-022594-fx044gcd	125	10	that	that	WDT
cord-022594-fx044gcd	125	11	MS	MS	NNP
cord-022594-fx044gcd	125	12	affects	affect	VBZ
cord-022594-fx044gcd	125	13	both	both	CC
cord-022594-fx044gcd	125	14	gray	gray	JJ
cord-022594-fx044gcd	125	15	and	and	CC
cord-022594-fx044gcd	125	16	white	white	JJ
cord-022594-fx044gcd	125	17	matter	matter	NN
cord-022594-fx044gcd	125	18	structures	structure	NNS
cord-022594-fx044gcd	125	19	.	.	.
cord-022594-fx044gcd	126	1	The	the	DT
cord-022594-fx044gcd	126	2	importance	importance	NN
cord-022594-fx044gcd	126	3	of	of	IN
cord-022594-fx044gcd	126	4	gray	gray	JJ
cord-022594-fx044gcd	126	5	matter	matter	NN
cord-022594-fx044gcd	126	6	involvement	involvement	NN
cord-022594-fx044gcd	126	7	has	have	VBZ
cord-022594-fx044gcd	126	8	received	receive	VBN
cord-022594-fx044gcd	126	9	little	little	JJ
cord-022594-fx044gcd	126	10	attention	attention	NN
cord-022594-fx044gcd	126	11	until	until	IN
cord-022594-fx044gcd	126	12	recently	recently	RB
cord-022594-fx044gcd	126	13	,	,	,
cord-022594-fx044gcd	126	14	largely	largely	RB
cord-022594-fx044gcd	126	15	due	due	JJ
cord-022594-fx044gcd	126	16	to	to	IN
cord-022594-fx044gcd	126	17	the	the	DT
cord-022594-fx044gcd	126	18	development	development	NN
cord-022594-fx044gcd	126	19	of	of	IN
cord-022594-fx044gcd	126	20	advanced	advanced	JJ
cord-022594-fx044gcd	126	21	MRI	MRI	NNP
cord-022594-fx044gcd	126	22	techniques	technique	NNS
cord-022594-fx044gcd	126	23	(	(	-LRB-
cord-022594-fx044gcd	126	24	see	see	VB
cord-022594-fx044gcd	126	25	later	later	RBR
cord-022594-fx044gcd	126	26	)	)	-RRB-
cord-022594-fx044gcd	126	27	that	that	WDT
cord-022594-fx044gcd	126	28	indicate	indicate	VBP
cord-022594-fx044gcd	126	29	neuronal	neuronal	JJ
cord-022594-fx044gcd	126	30	and	and	CC
cord-022594-fx044gcd	126	31	axonal	axonal	JJ
cord-022594-fx044gcd	126	32	involvement	involvement	NN
cord-022594-fx044gcd	126	33	even	even	RB
cord-022594-fx044gcd	126	34	in	in	IN
cord-022594-fx044gcd	126	35	the	the	DT
cord-022594-fx044gcd	126	36	earliest	early	JJS
cord-022594-fx044gcd	126	37	stages	stage	NNS
cord-022594-fx044gcd	126	38	of	of	IN
cord-022594-fx044gcd	126	39	this	this	DT
cord-022594-fx044gcd	126	40	disease	disease	NN
cord-022594-fx044gcd	126	41	.	.	.
cord-022594-fx044gcd	127	1	A	a	DT
cord-022594-fx044gcd	127	2	classification	classification	NN
cord-022594-fx044gcd	127	3	system	system	NN
cord-022594-fx044gcd	127	4	of	of	IN
cord-022594-fx044gcd	127	5	gray	gray	JJ
cord-022594-fx044gcd	127	6	matter	matter	NN
cord-022594-fx044gcd	127	7	plaques	plaque	NNS
cord-022594-fx044gcd	127	8	was	be	VBD
cord-022594-fx044gcd	127	9	proposed	propose	VBN
cord-022594-fx044gcd	127	10	by	by	IN
cord-022594-fx044gcd	127	11	Peterson	Peterson	NNP
cord-022594-fx044gcd	127	12	and	and	CC
cord-022594-fx044gcd	127	13	associates	associate	NNS
cord-022594-fx044gcd	127	14	18	18	CD
cord-022594-fx044gcd	128	1	They	-PRON-	PRP
cord-022594-fx044gcd	128	2	described	describe	VBD
cord-022594-fx044gcd	128	3	three	three	CD
cord-022594-fx044gcd	128	4	patterns	pattern	NNS
cord-022594-fx044gcd	128	5	of	of	IN
cord-022594-fx044gcd	128	6	cortical	cortical	JJ
cord-022594-fx044gcd	128	7	demyelination	demyelination	NN
cord-022594-fx044gcd	128	8	:	:	:
cord-022594-fx044gcd	129	1	type	type	NN
cord-022594-fx044gcd	129	2	I	-PRON-	PRP
cord-022594-fx044gcd	129	3	lesions	lesion	NNS
cord-022594-fx044gcd	129	4	are	be	VBP
cord-022594-fx044gcd	129	5	contiguous	contiguous	JJ
cord-022594-fx044gcd	129	6	with	with	IN
cord-022594-fx044gcd	129	7	subcortical	subcortical	JJ
cord-022594-fx044gcd	129	8	white	white	JJ
cord-022594-fx044gcd	129	9	matter	matter	NN
cord-022594-fx044gcd	129	10	lesions	lesion	NNS
cord-022594-fx044gcd	129	11	;	;	:
cord-022594-fx044gcd	129	12	type	type	NN
cord-022594-fx044gcd	129	13	II	ii	CD
cord-022594-fx044gcd	129	14	lesions	lesion	NNS
cord-022594-fx044gcd	129	15	are	be	VBP
cord-022594-fx044gcd	129	16	confined	confine	VBN
cord-022594-fx044gcd	129	17	to	to	IN
cord-022594-fx044gcd	129	18	the	the	DT
cord-022594-fx044gcd	129	19	cortex	cortex	NN
cord-022594-fx044gcd	129	20	,	,	,
cord-022594-fx044gcd	129	21	and	and	CC
cord-022594-fx044gcd	129	22	are	be	VBP
cord-022594-fx044gcd	129	23	often	often	RB
cord-022594-fx044gcd	129	24	perivascular	perivascular	JJ
cord-022594-fx044gcd	129	25	;	;	:
cord-022594-fx044gcd	129	26	type	type	NN
cord-022594-fx044gcd	129	27	III	iii	CD
cord-022594-fx044gcd	129	28	lesions	lesion	NNS
cord-022594-fx044gcd	129	29	extend	extend	VBP
cord-022594-fx044gcd	129	30	from	from	IN
cord-022594-fx044gcd	129	31	the	the	DT
cord-022594-fx044gcd	129	32	pial	pial	JJ
cord-022594-fx044gcd	129	33	surface	surface	NN
cord-022594-fx044gcd	129	34	to	to	IN
cord-022594-fx044gcd	129	35	cortical	cortical	JJ
cord-022594-fx044gcd	129	36	layer	layer	NN
cord-022594-fx044gcd	129	37	3	3	CD
cord-022594-fx044gcd	129	38	or	or	CC
cord-022594-fx044gcd	129	39	4	4	CD
cord-022594-fx044gcd	129	40	.	.	.
cord-022594-fx044gcd	130	1	Besides	besides	IN
cord-022594-fx044gcd	130	2	cortical	cortical	JJ
cord-022594-fx044gcd	130	3	gray	gray	JJ
cord-022594-fx044gcd	130	4	matter	matter	NN
cord-022594-fx044gcd	130	5	involvement	involvement	NN
cord-022594-fx044gcd	130	6	,	,	,
cord-022594-fx044gcd	130	7	there	there	EX
cord-022594-fx044gcd	130	8	is	be	VBZ
cord-022594-fx044gcd	130	9	also	also	RB
cord-022594-fx044gcd	130	10	evidence	evidence	NN
cord-022594-fx044gcd	130	11	for	for	IN
cord-022594-fx044gcd	130	12	prominent	prominent	JJ
cord-022594-fx044gcd	130	13	basal	basal	NN
cord-022594-fx044gcd	130	14	ganglia	ganglion	NNS
cord-022594-fx044gcd	130	15	involvement	involvement	NN
cord-022594-fx044gcd	130	16	,	,	,
cord-022594-fx044gcd	130	17	which	which	WDT
cord-022594-fx044gcd	130	18	can	can	MD
cord-022594-fx044gcd	130	19	be	be	VB
cord-022594-fx044gcd	130	20	seen	see	VBN
cord-022594-fx044gcd	130	21	in	in	IN
cord-022594-fx044gcd	130	22	the	the	DT
cord-022594-fx044gcd	130	23	early	early	JJ
cord-022594-fx044gcd	130	24	stages	stage	NNS
cord-022594-fx044gcd	130	25	of	of	IN
cord-022594-fx044gcd	130	26	MS	MS	NNP
cord-022594-fx044gcd	130	27	,	,	,
cord-022594-fx044gcd	130	28	and	and	CC
cord-022594-fx044gcd	130	29	may	may	MD
cord-022594-fx044gcd	130	30	correlate	correlate	VB
cord-022594-fx044gcd	130	31	better	well	RBR
cord-022594-fx044gcd	130	32	with	with	IN
cord-022594-fx044gcd	130	33	motor	motor	NN
cord-022594-fx044gcd	130	34	outcome	outcome	NN
cord-022594-fx044gcd	130	35	and	and	CC
cord-022594-fx044gcd	130	36	cognitive	cognitive	JJ
cord-022594-fx044gcd	130	37	measures	measure	NNS
cord-022594-fx044gcd	130	38	than	than	IN
cord-022594-fx044gcd	130	39	measures	measure	NNS
cord-022594-fx044gcd	130	40	of	of	IN
cord-022594-fx044gcd	130	41	white	white	JJ
cord-022594-fx044gcd	130	42	matter	matter	NN
cord-022594-fx044gcd	130	43	involvement	involvement	NN
cord-022594-fx044gcd	130	44	.	.	.
cord-022594-fx044gcd	131	1	Lucchinetti	Lucchinetti	NNP
cord-022594-fx044gcd	131	2	and	and	CC
cord-022594-fx044gcd	131	3	associates	associate	NNS
cord-022594-fx044gcd	131	4	demonstrated	demonstrate	VBD
cord-022594-fx044gcd	131	5	that	that	IN
cord-022594-fx044gcd	131	6	biopsy	biopsy	NN
cord-022594-fx044gcd	131	7	samples	sample	NNS
cord-022594-fx044gcd	131	8	from	from	IN
cord-022594-fx044gcd	131	9	newly	newly	RB
cord-022594-fx044gcd	131	10	diagnosed	diagnose	VBN
cord-022594-fx044gcd	131	11	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	131	12	cases	case	NNS
cord-022594-fx044gcd	131	13	contain	contain	VBP
cord-022594-fx044gcd	131	14	numerous	numerous	JJ
cord-022594-fx044gcd	131	15	infiltrating	infiltrate	VBG
cord-022594-fx044gcd	131	16	immune	immune	JJ
cord-022594-fx044gcd	131	17	cells	cell	NNS
cord-022594-fx044gcd	131	18	,	,	,
cord-022594-fx044gcd	131	19	and	and	CC
cord-022594-fx044gcd	131	20	can	can	MD
cord-022594-fx044gcd	131	21	be	be	VB
cord-022594-fx044gcd	131	22	destructive	destructive	JJ
cord-022594-fx044gcd	131	23	.	.	.
cord-022594-fx044gcd	132	1	The	the	DT
cord-022594-fx044gcd	132	2	pathological	pathological	JJ
cord-022594-fx044gcd	132	3	classification	classification	NN
cord-022594-fx044gcd	132	4	of	of	IN
cord-022594-fx044gcd	132	5	cortical	cortical	JJ
cord-022594-fx044gcd	132	6	lesions	lesion	NNS
cord-022594-fx044gcd	132	7	as	as	IN
cord-022594-fx044gcd	132	8	described	describe	VBN
cord-022594-fx044gcd	132	9	by	by	IN
cord-022594-fx044gcd	132	10	Petersen	Petersen	NNP
cord-022594-fx044gcd	132	11	can	can	MD
cord-022594-fx044gcd	132	12	also	also	RB
cord-022594-fx044gcd	132	13	be	be	VB
cord-022594-fx044gcd	132	14	found	find	VBN
cord-022594-fx044gcd	132	15	in	in	IN
cord-022594-fx044gcd	132	16	these	these	DT
cord-022594-fx044gcd	132	17	early	early	JJ
cord-022594-fx044gcd	132	18	MS	MS	NNP
cord-022594-fx044gcd	132	19	biopsy	biopsy	NN
cord-022594-fx044gcd	132	20	samples	sample	NNS
cord-022594-fx044gcd	132	21	.	.	.
cord-022594-fx044gcd	133	1	Approximately	approximately	RB
cord-022594-fx044gcd	133	2	20	20	CD
cord-022594-fx044gcd	133	3	%	%	NN
cord-022594-fx044gcd	133	4	of	of	IN
cord-022594-fx044gcd	133	5	biopsy	biopsy	NN
cord-022594-fx044gcd	133	6	cases	case	NNS
cord-022594-fx044gcd	133	7	in	in	IN
cord-022594-fx044gcd	133	8	which	which	WDT
cord-022594-fx044gcd	133	9	gray	gray	JJ
cord-022594-fx044gcd	133	10	matter	matter	NN
cord-022594-fx044gcd	133	11	was	be	VBD
cord-022594-fx044gcd	133	12	also	also	RB
cord-022594-fx044gcd	133	13	sampled	sample	VBN
cord-022594-fx044gcd	133	14	had	have	VBD
cord-022594-fx044gcd	133	15	evidence	evidence	NN
cord-022594-fx044gcd	133	16	of	of	IN
cord-022594-fx044gcd	133	17	clear	clear	JJ
cord-022594-fx044gcd	133	18	cortical	cortical	JJ
cord-022594-fx044gcd	133	19	demyelination	demyelination	NN
cord-022594-fx044gcd	133	20	.	.	.
cord-022594-fx044gcd	134	1	In	in	IN
cord-022594-fx044gcd	134	2	2005	2005	CD
cord-022594-fx044gcd	134	3	,	,	,
cord-022594-fx044gcd	134	4	an	an	DT
cord-022594-fx044gcd	134	5	extensive	extensive	JJ
cord-022594-fx044gcd	134	6	histological	histological	JJ
cord-022594-fx044gcd	134	7	study	study	NN
cord-022594-fx044gcd	134	8	by	by	IN
cord-022594-fx044gcd	134	9	Kutzelnigg	Kutzelnigg	NNP
cord-022594-fx044gcd	134	10	and	and	CC
cord-022594-fx044gcd	134	11	associates	associate	NNS
cord-022594-fx044gcd	134	12	investigated	investigate	VBD
cord-022594-fx044gcd	134	13	the	the	DT
cord-022594-fx044gcd	134	14	role	role	NN
cord-022594-fx044gcd	134	15	of	of	IN
cord-022594-fx044gcd	134	16	cortical	cortical	JJ
cord-022594-fx044gcd	134	17	demyelination	demyelination	NN
cord-022594-fx044gcd	134	18	in	in	IN
cord-022594-fx044gcd	134	19	all	all	DT
cord-022594-fx044gcd	134	20	clinical	clinical	JJ
cord-022594-fx044gcd	134	21	subtypes	subtype	NNS
cord-022594-fx044gcd	134	22	of	of	IN
cord-022594-fx044gcd	134	23	MS	MS	NNP
cord-022594-fx044gcd	134	24	.	.	.
cord-022594-fx044gcd	135	1	19	19	CD
cord-022594-fx044gcd	136	1	In	in	IN
cord-022594-fx044gcd	136	2	this	this	DT
cord-022594-fx044gcd	136	3	study	study	NN
cord-022594-fx044gcd	136	4	,	,	,
cord-022594-fx044gcd	136	5	52	52	CD
cord-022594-fx044gcd	136	6	brains	brain	NNS
cord-022594-fx044gcd	136	7	of	of	IN
cord-022594-fx044gcd	136	8	MS	MS	NNP
cord-022594-fx044gcd	136	9	patients	patient	NNS
cord-022594-fx044gcd	136	10	(	(	-LRB-
cord-022594-fx044gcd	136	11	relapsing	relapse	VBG
cord-022594-fx044gcd	136	12	-	-	HYPH
cord-022594-fx044gcd	136	13	remitting	remit	VBG
cord-022594-fx044gcd	136	14	[	[	-LRB-
cord-022594-fx044gcd	136	15	RR	rr	NN
cord-022594-fx044gcd	136	16	]	]	-RRB-
cord-022594-fx044gcd	136	17	,	,	,
cord-022594-fx044gcd	136	18	secondary	secondary	JJ
cord-022594-fx044gcd	136	19	progressive	progressive	JJ
cord-022594-fx044gcd	136	20	[	[	-LRB-
cord-022594-fx044gcd	136	21	SP	SP	NNP
cord-022594-fx044gcd	136	22	]	]	-RRB-
cord-022594-fx044gcd	136	23	,	,	,
cord-022594-fx044gcd	136	24	and	and	CC
cord-022594-fx044gcd	136	25	PPMS	PPMS	NNP
cord-022594-fx044gcd	136	26	)	)	-RRB-
cord-022594-fx044gcd	136	27	and	and	CC
cord-022594-fx044gcd	136	28	30	30	CD
cord-022594-fx044gcd	136	29	control	control	NN
cord-022594-fx044gcd	136	30	subjects	subject	NNS
cord-022594-fx044gcd	136	31	were	be	VBD
cord-022594-fx044gcd	136	32	studied	study	VBN
cord-022594-fx044gcd	136	33	using	use	VBG
cord-022594-fx044gcd	136	34	advanced	advanced	JJ
cord-022594-fx044gcd	136	35	quantitative	quantitative	JJ
cord-022594-fx044gcd	136	36	morphological	morphological	JJ
cord-022594-fx044gcd	136	37	techniques	technique	NNS
cord-022594-fx044gcd	136	38	.	.	.
cord-022594-fx044gcd	137	1	Cortical	cortical	JJ
cord-022594-fx044gcd	137	2	demyelination	demyelination	NN
cord-022594-fx044gcd	137	3	and	and	CC
cord-022594-fx044gcd	137	4	diffuse	diffuse	VB
cord-022594-fx044gcd	137	5	axonal	axonal	JJ
cord-022594-fx044gcd	137	6	injury	injury	NN
cord-022594-fx044gcd	137	7	in	in	IN
cord-022594-fx044gcd	137	8	the	the	DT
cord-022594-fx044gcd	137	9	normal	normal	JJ
cord-022594-fx044gcd	137	10	appearing	appear	VBG
cord-022594-fx044gcd	137	11	white	white	JJ
cord-022594-fx044gcd	137	12	matter	matter	NN
cord-022594-fx044gcd	137	13	(	(	-LRB-
cord-022594-fx044gcd	137	14	NAWM	NAWM	NNP
cord-022594-fx044gcd	137	15	)	)	-RRB-
cord-022594-fx044gcd	137	16	were	be	VBD
cord-022594-fx044gcd	137	17	reported	report	VBN
cord-022594-fx044gcd	137	18	as	as	IN
cord-022594-fx044gcd	137	19	hallmarks	hallmark	NNS
cord-022594-fx044gcd	137	20	of	of	IN
cord-022594-fx044gcd	137	21	progressive	progressive	JJ
cord-022594-fx044gcd	137	22	forms	form	NNS
cord-022594-fx044gcd	137	23	of	of	IN
cord-022594-fx044gcd	137	24	MS	MS	NNP
cord-022594-fx044gcd	137	25	.	.	.
cord-022594-fx044gcd	138	1	Cortical	cortical	JJ
cord-022594-fx044gcd	138	2	demyelination	demyelination	NN
cord-022594-fx044gcd	138	3	was	be	VBD
cord-022594-fx044gcd	138	4	mainly	mainly	RB
cord-022594-fx044gcd	138	5	seen	see	VBN
cord-022594-fx044gcd	138	6	in	in	IN
cord-022594-fx044gcd	138	7	the	the	DT
cord-022594-fx044gcd	138	8	subpial	subpial	JJ
cord-022594-fx044gcd	138	9	layer	layer	NN
cord-022594-fx044gcd	138	10	of	of	IN
cord-022594-fx044gcd	138	11	cortex	cortex	NN
cord-022594-fx044gcd	138	12	,	,	,
cord-022594-fx044gcd	138	13	and	and	CC
cord-022594-fx044gcd	138	14	was	be	VBD
cord-022594-fx044gcd	138	15	associated	associate	VBN
cord-022594-fx044gcd	138	16	with	with	IN
cord-022594-fx044gcd	138	17	significant	significant	JJ
cord-022594-fx044gcd	138	18	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	138	19	infiltrates	infiltrate	NNS
cord-022594-fx044gcd	138	20	in	in	IN
cord-022594-fx044gcd	138	21	the	the	DT
cord-022594-fx044gcd	138	22	surrounding	surround	VBG
cord-022594-fx044gcd	138	23	meninges	meninge	NNS
cord-022594-fx044gcd	138	24	.	.	.
cord-022594-fx044gcd	139	1	Diffuse	diffuse	JJ
cord-022594-fx044gcd	139	2	inflammation	inflammation	NN
cord-022594-fx044gcd	139	3	was	be	VBD
cord-022594-fx044gcd	139	4	also	also	RB
cord-022594-fx044gcd	139	5	found	find	VBN
cord-022594-fx044gcd	139	6	throughout	throughout	IN
cord-022594-fx044gcd	139	7	the	the	DT
cord-022594-fx044gcd	139	8	white	white	JJ
cord-022594-fx044gcd	139	9	matter	matter	NN
cord-022594-fx044gcd	139	10	of	of	IN
cord-022594-fx044gcd	139	11	the	the	DT
cord-022594-fx044gcd	139	12	progressive	progressive	JJ
cord-022594-fx044gcd	139	13	cases	case	NNS
cord-022594-fx044gcd	139	14	,	,	,
cord-022594-fx044gcd	139	15	associated	associate	VBN
cord-022594-fx044gcd	139	16	with	with	IN
cord-022594-fx044gcd	139	17	activation	activation	NN
cord-022594-fx044gcd	139	18	of	of	IN
cord-022594-fx044gcd	139	19	microglia	microglia	NNP
cord-022594-fx044gcd	139	20	.	.	.
cord-022594-fx044gcd	140	1	No	no	DT
cord-022594-fx044gcd	140	2	significant	significant	JJ
cord-022594-fx044gcd	140	3	correlation	correlation	NN
cord-022594-fx044gcd	140	4	was	be	VBD
cord-022594-fx044gcd	140	5	shown	show	VBN
cord-022594-fx044gcd	140	6	between	between	IN
cord-022594-fx044gcd	140	7	focal	focal	JJ
cord-022594-fx044gcd	140	8	white	white	JJ
cord-022594-fx044gcd	140	9	matter	matter	NN
cord-022594-fx044gcd	140	10	lesion	lesion	NN
cord-022594-fx044gcd	140	11	load	load	NN
cord-022594-fx044gcd	140	12	and	and	CC
cord-022594-fx044gcd	140	13	cortical	cortical	JJ
cord-022594-fx044gcd	140	14	demyelination	demyelination	NN
cord-022594-fx044gcd	140	15	.	.	.
cord-022594-fx044gcd	141	1	This	this	DT
cord-022594-fx044gcd	141	2	study	study	NN
cord-022594-fx044gcd	141	3	defines	define	VBZ
cord-022594-fx044gcd	141	4	three	three	CD
cord-022594-fx044gcd	141	5	crucially	crucially	RB
cord-022594-fx044gcd	141	6	important	important	JJ
cord-022594-fx044gcd	141	7	pathological	pathological	JJ
cord-022594-fx044gcd	141	8	hallmarks	hallmark	NNS
cord-022594-fx044gcd	141	9	of	of	IN
cord-022594-fx044gcd	141	10	MS	MS	NNP
cord-022594-fx044gcd	141	11	-	-	HYPH
cord-022594-fx044gcd	141	12	focal	focal	JJ
cord-022594-fx044gcd	141	13	demyelinated	demyelinated	JJ
cord-022594-fx044gcd	141	14	white	white	JJ
cord-022594-fx044gcd	141	15	matter	matter	NN
cord-022594-fx044gcd	141	16	lesions	lesion	NNS
cord-022594-fx044gcd	141	17	,	,	,
cord-022594-fx044gcd	141	18	diffuse	diffuse	VBP
cord-022594-fx044gcd	141	19	injury	injury	NN
cord-022594-fx044gcd	141	20	in	in	IN
cord-022594-fx044gcd	141	21	the	the	DT
cord-022594-fx044gcd	141	22	white	white	JJ
cord-022594-fx044gcd	141	23	matter	matter	NN
cord-022594-fx044gcd	141	24	,	,	,
cord-022594-fx044gcd	141	25	and	and	CC
cord-022594-fx044gcd	141	26	cortical	cortical	JJ
cord-022594-fx044gcd	141	27	plaque	plaque	NN
cord-022594-fx044gcd	141	28	formation	formation	NN
cord-022594-fx044gcd	141	29	-	-	,
cord-022594-fx044gcd	141	30	and	and	CC
cord-022594-fx044gcd	141	31	concludes	conclude	VBZ
cord-022594-fx044gcd	141	32	that	that	IN
cord-022594-fx044gcd	141	33	white	white	JJ
cord-022594-fx044gcd	141	34	matter	matter	NN
cord-022594-fx044gcd	141	35	lesion	lesion	NN
cord-022594-fx044gcd	141	36	formation	formation	NN
cord-022594-fx044gcd	141	37	predominates	predominate	VBZ
cord-022594-fx044gcd	141	38	in	in	IN
cord-022594-fx044gcd	141	39	active	active	JJ
cord-022594-fx044gcd	141	40	forms	form	NNS
cord-022594-fx044gcd	141	41	of	of	IN
cord-022594-fx044gcd	141	42	MS	MS	NNP
cord-022594-fx044gcd	141	43	,	,	,
cord-022594-fx044gcd	141	44	while	while	IN
cord-022594-fx044gcd	141	45	cortical	cortical	JJ
cord-022594-fx044gcd	141	46	pathology	pathology	NN
cord-022594-fx044gcd	141	47	and	and	CC
cord-022594-fx044gcd	141	48	diffuse	diffuse	VB
cord-022594-fx044gcd	141	49	white	white	JJ
cord-022594-fx044gcd	141	50	matter	matter	NN
cord-022594-fx044gcd	141	51	injury	injury	NN
cord-022594-fx044gcd	141	52	characterizes	characterize	VBZ
cord-022594-fx044gcd	141	53	the	the	DT
cord-022594-fx044gcd	141	54	progressive	progressive	JJ
cord-022594-fx044gcd	141	55	forms	form	NNS
cord-022594-fx044gcd	141	56	.	.	.
cord-022594-fx044gcd	142	1	The	the	DT
cord-022594-fx044gcd	142	2	authors	author	NNS
cord-022594-fx044gcd	142	3	of	of	IN
cord-022594-fx044gcd	142	4	this	this	DT
cord-022594-fx044gcd	142	5	landmark	landmark	NN
cord-022594-fx044gcd	142	6	paper	paper	NN
cord-022594-fx044gcd	142	7	also	also	RB
cord-022594-fx044gcd	142	8	established	establish	VBD
cord-022594-fx044gcd	142	9	that	that	IN
cord-022594-fx044gcd	142	10	these	these	DT
cord-022594-fx044gcd	142	11	three	three	CD
cord-022594-fx044gcd	142	12	processes	process	NNS
cord-022594-fx044gcd	142	13	are	be	VBP
cord-022594-fx044gcd	142	14	potentially	potentially	RB
cord-022594-fx044gcd	142	15	independent	independent	JJ
cord-022594-fx044gcd	142	16	of	of	IN
cord-022594-fx044gcd	142	17	each	each	DT
cord-022594-fx044gcd	142	18	other	other	JJ
cord-022594-fx044gcd	142	19	.	.	.
cord-022594-fx044gcd	143	1	Heredity	heredity	NN
cord-022594-fx044gcd	143	2	.	.	.
cord-022594-fx044gcd	144	1	Epidemiological	epidemiological	JJ
cord-022594-fx044gcd	144	2	findings	finding	NNS
cord-022594-fx044gcd	144	3	support	support	VBP
cord-022594-fx044gcd	144	4	a	a	DT
cord-022594-fx044gcd	144	5	polygenic	polygenic	JJ
cord-022594-fx044gcd	144	6	hereditary	hereditary	JJ
cord-022594-fx044gcd	144	7	predisposition	predisposition	NN
cord-022594-fx044gcd	144	8	to	to	IN
cord-022594-fx044gcd	144	9	MS	MS	NNP
cord-022594-fx044gcd	144	10	.	.	.
cord-022594-fx044gcd	145	1	A	a	DT
cord-022594-fx044gcd	145	2	number	number	NN
cord-022594-fx044gcd	145	3	of	of	IN
cord-022594-fx044gcd	145	4	candidate	candidate	NN
cord-022594-fx044gcd	145	5	genes	gene	NNS
cord-022594-fx044gcd	145	6	have	have	VBP
cord-022594-fx044gcd	145	7	been	be	VBN
cord-022594-fx044gcd	145	8	investigated	investigate	VBN
cord-022594-fx044gcd	145	9	,	,	,
cord-022594-fx044gcd	145	10	often	often	RB
cord-022594-fx044gcd	145	11	with	with	IN
cord-022594-fx044gcd	145	12	conflicting	conflicting	JJ
cord-022594-fx044gcd	145	13	results	result	NNS
cord-022594-fx044gcd	145	14	.	.	.
cord-022594-fx044gcd	146	1	The	the	DT
cord-022594-fx044gcd	146	2	only	only	JJ
cord-022594-fx044gcd	146	3	definitive	definitive	JJ
cord-022594-fx044gcd	146	4	genetic	genetic	JJ
cord-022594-fx044gcd	146	5	association	association	NN
cord-022594-fx044gcd	146	6	in	in	IN
cord-022594-fx044gcd	146	7	MS	MS	NNP
cord-022594-fx044gcd	146	8	is	be	VBZ
cord-022594-fx044gcd	146	9	with	with	IN
cord-022594-fx044gcd	146	10	the	the	DT
cord-022594-fx044gcd	146	11	serologically	serologically	RB
cord-022594-fx044gcd	146	12	defined	define	VBN
cord-022594-fx044gcd	146	13	human	human	JJ
cord-022594-fx044gcd	146	14	leukocyte	leukocyte	NN
cord-022594-fx044gcd	146	15	antigen	antigen	NN
cord-022594-fx044gcd	146	16	(	(	-LRB-
cord-022594-fx044gcd	146	17	HLA	HLA	NNP
cord-022594-fx044gcd	146	18	)	)	-RRB-
cord-022594-fx044gcd	146	19	DR15	DR15	NNP
cord-022594-fx044gcd	146	20	,	,	,
cord-022594-fx044gcd	146	21	DQ6	dq6	JJ
cord-022594-fx044gcd	146	22	.	.	.
cord-022594-fx044gcd	147	1	This	this	DT
cord-022594-fx044gcd	147	2	is	be	VBZ
cord-022594-fx044gcd	147	3	one	one	CD
cord-022594-fx044gcd	147	4	of	of	IN
cord-022594-fx044gcd	147	5	the	the	DT
cord-022594-fx044gcd	147	6	DR2	DR2	NNP
cord-022594-fx044gcd	147	7	haplotypes	haplotype	NNS
cord-022594-fx044gcd	147	8	,	,	,
cord-022594-fx044gcd	147	9	also	also	RB
cord-022594-fx044gcd	147	10	known	know	VBN
cord-022594-fx044gcd	147	11	as	as	IN
cord-022594-fx044gcd	147	12	Dw2	dw2	NN
cord-022594-fx044gcd	147	13	in	in	IN
cord-022594-fx044gcd	147	14	cellular	cellular	JJ
cord-022594-fx044gcd	147	15	terminology	terminology	NN
cord-022594-fx044gcd	147	16	and	and	CC
cord-022594-fx044gcd	147	17	DRB1	DRB1	NNP
cord-022594-fx044gcd	148	1	*	*	NFP
cord-022594-fx044gcd	148	2	1501	1501	CD
cord-022594-fx044gcd	148	3	,	,	,
cord-022594-fx044gcd	148	4	DQA1	DQA1	NNPS
cord-022594-fx044gcd	148	5	*	*	NFP
cord-022594-fx044gcd	148	6	0102	0102	CD
cord-022594-fx044gcd	148	7	,	,	,
cord-022594-fx044gcd	148	8	DQB1	DQB1	NNP
cord-022594-fx044gcd	148	9	*	*	NFP
cord-022594-fx044gcd	148	10	0602	0602	CD
cord-022594-fx044gcd	148	11	in	in	IN
cord-022594-fx044gcd	148	12	molecular	molecular	JJ
cord-022594-fx044gcd	148	13	nomenclature	nomenclature	NN
cord-022594-fx044gcd	148	14	.	.	.
cord-022594-fx044gcd	149	1	Though	though	IN
cord-022594-fx044gcd	149	2	its	-PRON-	PRP$
cord-022594-fx044gcd	149	3	link	link	NN
cord-022594-fx044gcd	149	4	to	to	IN
cord-022594-fx044gcd	149	5	MS	MS	NNP
cord-022594-fx044gcd	149	6	is	be	VBZ
cord-022594-fx044gcd	149	7	well	well	RB
cord-022594-fx044gcd	149	8	established	establish	VBN
cord-022594-fx044gcd	149	9	,	,	,
cord-022594-fx044gcd	149	10	the	the	DT
cord-022594-fx044gcd	149	11	risk	risk	NN
cord-022594-fx044gcd	149	12	conferred	confer	VBN
cord-022594-fx044gcd	149	13	by	by	IN
cord-022594-fx044gcd	149	14	this	this	DT
cord-022594-fx044gcd	149	15	haplotype	haplotype	NN
cord-022594-fx044gcd	149	16	is	be	VBZ
cord-022594-fx044gcd	149	17	small	small	JJ
cord-022594-fx044gcd	149	18	(	(	-LRB-
cord-022594-fx044gcd	149	19	relative	relative	JJ
cord-022594-fx044gcd	149	20	risk	risk	NN
cord-022594-fx044gcd	149	21	of	of	IN
cord-022594-fx044gcd	149	22	3	3	CD
cord-022594-fx044gcd	149	23	to	to	IN
cord-022594-fx044gcd	149	24	4	4	CD
cord-022594-fx044gcd	149	25	)	)	-RRB-
cord-022594-fx044gcd	149	26	,	,	,
cord-022594-fx044gcd	149	27	and	and	CC
cord-022594-fx044gcd	149	28	it	-PRON-	PRP
cord-022594-fx044gcd	149	29	is	be	VBZ
cord-022594-fx044gcd	149	30	neither	neither	CC
cord-022594-fx044gcd	149	31	necessary	necessary	JJ
cord-022594-fx044gcd	149	32	nor	nor	CC
cord-022594-fx044gcd	149	33	sufficient	sufficient	JJ
cord-022594-fx044gcd	149	34	for	for	IN
cord-022594-fx044gcd	149	35	the	the	DT
cord-022594-fx044gcd	149	36	development	development	NN
cord-022594-fx044gcd	149	37	of	of	IN
cord-022594-fx044gcd	149	38	MS	MS	NNP
cord-022594-fx044gcd	149	39	.	.	.
cord-022594-fx044gcd	150	1	Linkage	linkage	NN
cord-022594-fx044gcd	150	2	to	to	IN
cord-022594-fx044gcd	150	3	this	this	DT
cord-022594-fx044gcd	150	4	locus	locus	NN
cord-022594-fx044gcd	150	5	has	have	VBZ
cord-022594-fx044gcd	150	6	not	not	RB
cord-022594-fx044gcd	150	7	been	be	VBN
cord-022594-fx044gcd	150	8	proved	prove	VBN
cord-022594-fx044gcd	150	9	,	,	,
cord-022594-fx044gcd	150	10	indicating	indicate	VBG
cord-022594-fx044gcd	150	11	that	that	IN
cord-022594-fx044gcd	150	12	it	-PRON-	PRP
cord-022594-fx044gcd	150	13	plays	play	VBZ
cord-022594-fx044gcd	150	14	only	only	RB
cord-022594-fx044gcd	150	15	a	a	DT
cord-022594-fx044gcd	150	16	minor	minor	JJ
cord-022594-fx044gcd	150	17	role	role	NN
cord-022594-fx044gcd	150	18	in	in	IN
cord-022594-fx044gcd	150	19	familial	familial	JJ
cord-022594-fx044gcd	150	20	susceptibility	susceptibility	NN
cord-022594-fx044gcd	150	21	.	.	.
cord-022594-fx044gcd	151	1	Other	other	JJ
cord-022594-fx044gcd	151	2	susceptibility	susceptibility	NN
cord-022594-fx044gcd	151	3	genes	gene	NNS
cord-022594-fx044gcd	151	4	likely	likely	RB
cord-022594-fx044gcd	151	5	contribute	contribute	VBP
cord-022594-fx044gcd	151	6	,	,	,
cord-022594-fx044gcd	151	7	possibly	possibly	RB
cord-022594-fx044gcd	151	8	the	the	DT
cord-022594-fx044gcd	151	9	T	t	NN
cord-022594-fx044gcd	151	10	-	-	HYPH
cord-022594-fx044gcd	151	11	cell	cell	NN
cord-022594-fx044gcd	151	12	receptor	receptor	NN
cord-022594-fx044gcd	151	13	variable	variable	NN
cord-022594-fx044gcd	151	14	b	b	NN
cord-022594-fx044gcd	151	15	region	region	NN
cord-022594-fx044gcd	151	16	and	and	CC
cord-022594-fx044gcd	151	17	the	the	DT
cord-022594-fx044gcd	151	18	IgG	IgG	NNP
cord-022594-fx044gcd	151	19	heavy	heavy	JJ
cord-022594-fx044gcd	151	20	-	-	HYPH
cord-022594-fx044gcd	151	21	chain	chain	NN
cord-022594-fx044gcd	151	22	variable	variable	NN
cord-022594-fx044gcd	151	23	region	region	NN
cord-022594-fx044gcd	151	24	(	(	-LRB-
cord-022594-fx044gcd	151	25	especially	especially	RB
cord-022594-fx044gcd	151	26	the	the	DT
cord-022594-fx044gcd	151	27	VH2	VH2	NNP
cord-022594-fx044gcd	151	28	-	-	HYPH
cord-022594-fx044gcd	151	29	5	5	CD
cord-022594-fx044gcd	151	30	gene	gene	NN
cord-022594-fx044gcd	151	31	)	)	-RRB-
cord-022594-fx044gcd	151	32	.	.	.
cord-022594-fx044gcd	152	1	But	but	CC
cord-022594-fx044gcd	152	2	their	-PRON-	PRP$
cord-022594-fx044gcd	152	3	specific	specific	JJ
cord-022594-fx044gcd	152	4	roles	role	NNS
cord-022594-fx044gcd	152	5	have	have	VBP
cord-022594-fx044gcd	152	6	not	not	RB
cord-022594-fx044gcd	152	7	been	be	VBN
cord-022594-fx044gcd	152	8	established	establish	VBN
cord-022594-fx044gcd	152	9	.	.	.
cord-022594-fx044gcd	153	1	Other	other	JJ
cord-022594-fx044gcd	153	2	genes	gene	NNS
cord-022594-fx044gcd	153	3	under	under	IN
cord-022594-fx044gcd	153	4	study	study	NN
cord-022594-fx044gcd	153	5	have	have	VBP
cord-022594-fx044gcd	153	6	been	be	VBN
cord-022594-fx044gcd	153	7	the	the	DT
cord-022594-fx044gcd	153	8	MBP	MBP	NNP
cord-022594-fx044gcd	153	9	coding	code	VBG
cord-022594-fx044gcd	153	10	gene	gene	NN
cord-022594-fx044gcd	153	11	,	,	,
cord-022594-fx044gcd	153	12	the	the	DT
cord-022594-fx044gcd	153	13	CTLA-4	CTLA-4	NNP
cord-022594-fx044gcd	153	14	gene	gene	NN
cord-022594-fx044gcd	153	15	on	on	IN
cord-022594-fx044gcd	153	16	chromosome	chromosome	NN
cord-022594-fx044gcd	153	17	2q33	2q33	CD
cord-022594-fx044gcd	153	18	,	,	,
cord-022594-fx044gcd	153	19	and	and	CC
cord-022594-fx044gcd	153	20	the	the	DT
cord-022594-fx044gcd	153	21	interleukin-1ra	interleukin-1ra	NNP
cord-022594-fx044gcd	153	22	associated	associate	VBN
cord-022594-fx044gcd	153	23	gene	gene	NN
cord-022594-fx044gcd	153	24	,	,	,
cord-022594-fx044gcd	153	25	in	in	IN
cord-022594-fx044gcd	153	26	concurrence	concurrence	NN
cord-022594-fx044gcd	153	27	with	with	IN
cord-022594-fx044gcd	153	28	the	the	DT
cord-022594-fx044gcd	153	29	HLA	HLA	NNP
cord-022594-fx044gcd	153	30	-	-	HYPH
cord-022594-fx044gcd	153	31	DR15	DR15	NNP
cord-022594-fx044gcd	153	32	haplotype	haplotype	NN
cord-022594-fx044gcd	153	33	.	.	.
cord-022594-fx044gcd	154	1	Mitochondrial	mitochondrial	JJ
cord-022594-fx044gcd	154	2	mutations	mutation	NNS
cord-022594-fx044gcd	154	3	are	be	VBP
cord-022594-fx044gcd	154	4	also	also	RB
cord-022594-fx044gcd	154	5	under	under	IN
cord-022594-fx044gcd	154	6	investigation	investigation	NN
cord-022594-fx044gcd	154	7	,	,	,
cord-022594-fx044gcd	154	8	and	and	CC
cord-022594-fx044gcd	154	9	an	an	DT
cord-022594-fx044gcd	154	10	LHON	LHON	NNP
cord-022594-fx044gcd	154	11	-	-	HYPH
cord-022594-fx044gcd	154	12	associated	associate	VBN
cord-022594-fx044gcd	154	13	mtDNA	mtdna	JJ
cord-022594-fx044gcd	154	14	mutation	mutation	NN
cord-022594-fx044gcd	154	15	may	may	MD
cord-022594-fx044gcd	154	16	be	be	VB
cord-022594-fx044gcd	154	17	an	an	DT
cord-022594-fx044gcd	154	18	important	important	JJ
cord-022594-fx044gcd	154	19	cofactor	cofactor	NN
cord-022594-fx044gcd	154	20	in	in	IN
cord-022594-fx044gcd	154	21	developing	develop	VBG
cord-022594-fx044gcd	154	22	MS	MS	NNP
cord-022594-fx044gcd	154	23	in	in	IN
cord-022594-fx044gcd	154	24	some	some	DT
cord-022594-fx044gcd	154	25	patients	patient	NNS
cord-022594-fx044gcd	154	26	.	.	.
cord-022594-fx044gcd	155	1	The	the	DT
cord-022594-fx044gcd	155	2	ApoE4	ApoE4	NNP
cord-022594-fx044gcd	155	3	gene	gene	NN
cord-022594-fx044gcd	155	4	,	,	,
cord-022594-fx044gcd	155	5	as	as	IN
cord-022594-fx044gcd	155	6	in	in	IN
cord-022594-fx044gcd	155	7	Alzheimer	Alzheimer	NNP
cord-022594-fx044gcd	155	8	's	's	POS
cord-022594-fx044gcd	155	9	disease	disease	NN
cord-022594-fx044gcd	155	10	,	,	,
cord-022594-fx044gcd	155	11	has	have	VBZ
cord-022594-fx044gcd	155	12	been	be	VBN
cord-022594-fx044gcd	155	13	associated	associate	VBN
cord-022594-fx044gcd	155	14	with	with	IN
cord-022594-fx044gcd	155	15	a	a	DT
cord-022594-fx044gcd	155	16	higher	high	JJR
cord-022594-fx044gcd	155	17	incidence	incidence	NN
cord-022594-fx044gcd	155	18	of	of	IN
cord-022594-fx044gcd	155	19	MS	MS	NNP
cord-022594-fx044gcd	155	20	.	.	.
cord-022594-fx044gcd	156	1	On	on	IN
cord-022594-fx044gcd	156	2	the	the	DT
cord-022594-fx044gcd	156	3	other	other	JJ
cord-022594-fx044gcd	156	4	hand	hand	NN
cord-022594-fx044gcd	156	5	,	,	,
cord-022594-fx044gcd	156	6	ApoE3	ApoE3	NNP
cord-022594-fx044gcd	156	7	is	be	VBZ
cord-022594-fx044gcd	156	8	considered	consider	VBN
cord-022594-fx044gcd	156	9	to	to	TO
cord-022594-fx044gcd	156	10	have	have	VB
cord-022594-fx044gcd	156	11	neurotropic	neurotropic	NNP
cord-022594-fx044gcd	156	12	,	,	,
cord-022594-fx044gcd	156	13	immunomodulatory	immunomodulatory	NNP
cord-022594-fx044gcd	156	14	,	,	,
cord-022594-fx044gcd	156	15	and	and	CC
cord-022594-fx044gcd	156	16	antioxidant	antioxidant	JJ
cord-022594-fx044gcd	156	17	properties	property	NNS
cord-022594-fx044gcd	156	18	.	.	.
cord-022594-fx044gcd	157	1	These	these	DT
cord-022594-fx044gcd	157	2	findings	finding	NNS
cord-022594-fx044gcd	157	3	are	be	VBP
cord-022594-fx044gcd	157	4	yet	yet	RB
cord-022594-fx044gcd	157	5	to	to	TO
cord-022594-fx044gcd	157	6	be	be	VB
cord-022594-fx044gcd	157	7	confirmed	confirm	VBN
cord-022594-fx044gcd	157	8	by	by	IN
cord-022594-fx044gcd	157	9	larger	large	JJR
cord-022594-fx044gcd	157	10	studies	study	NNS
cord-022594-fx044gcd	157	11	.	.	.
cord-022594-fx044gcd	158	1	Twenty	twenty	CD
cord-022594-fx044gcd	158	2	percent	percent	NN
cord-022594-fx044gcd	158	3	of	of	IN
cord-022594-fx044gcd	158	4	MS	MS	NNP
cord-022594-fx044gcd	158	5	patients	patient	NNS
cord-022594-fx044gcd	158	6	have	have	VBP
cord-022594-fx044gcd	158	7	at	at	RB
cord-022594-fx044gcd	158	8	least	least	RBS
cord-022594-fx044gcd	158	9	one	one	CD
cord-022594-fx044gcd	158	10	affected	affect	VBN
cord-022594-fx044gcd	158	11	relative	relative	NN
cord-022594-fx044gcd	158	12	.	.	.
cord-022594-fx044gcd	159	1	Only	only	RB
cord-022594-fx044gcd	159	2	about	about	IN
cord-022594-fx044gcd	159	3	4	4	CD
cord-022594-fx044gcd	159	4	%	%	NN
cord-022594-fx044gcd	159	5	of	of	IN
cord-022594-fx044gcd	159	6	first	first	JJ
cord-022594-fx044gcd	159	7	-	-	HYPH
cord-022594-fx044gcd	159	8	degree	degree	NN
cord-022594-fx044gcd	159	9	relatives	relative	NNS
cord-022594-fx044gcd	159	10	of	of	IN
cord-022594-fx044gcd	159	11	patients	patient	NNS
cord-022594-fx044gcd	159	12	develop	develop	VBP
cord-022594-fx044gcd	159	13	MS	MS	NNP
cord-022594-fx044gcd	159	14	,	,	,
cord-022594-fx044gcd	159	15	but	but	CC
cord-022594-fx044gcd	159	16	this	this	DT
cord-022594-fx044gcd	159	17	represents	represent	VBZ
cord-022594-fx044gcd	159	18	a	a	DT
cord-022594-fx044gcd	159	19	20-to	20-to	CD
cord-022594-fx044gcd	159	20	40-fold	40-fold	CD
cord-022594-fx044gcd	159	21	increase	increase	NN
cord-022594-fx044gcd	159	22	in	in	IN
cord-022594-fx044gcd	159	23	risk	risk	NN
cord-022594-fx044gcd	159	24	compared	compare	VBN
cord-022594-fx044gcd	159	25	with	with	IN
cord-022594-fx044gcd	159	26	the	the	DT
cord-022594-fx044gcd	159	27	general	general	JJ
cord-022594-fx044gcd	159	28	population	population	NN
cord-022594-fx044gcd	159	29	.	.	.
cord-022594-fx044gcd	160	1	Unaffected	unaffected	JJ
cord-022594-fx044gcd	160	2	family	family	NN
cord-022594-fx044gcd	160	3	members	member	NNS
cord-022594-fx044gcd	160	4	sometimes	sometimes	RB
cord-022594-fx044gcd	160	5	have	have	VBP
cord-022594-fx044gcd	160	6	abnormal	abnormal	JJ
cord-022594-fx044gcd	160	7	findings	finding	NNS
cord-022594-fx044gcd	160	8	on	on	IN
cord-022594-fx044gcd	160	9	cranial	cranial	JJ
cord-022594-fx044gcd	160	10	MRI	MRI	NNP
cord-022594-fx044gcd	160	11	,	,	,
cord-022594-fx044gcd	160	12	implying	imply	VBG
cord-022594-fx044gcd	160	13	that	that	IN
cord-022594-fx044gcd	160	14	this	this	DT
cord-022594-fx044gcd	160	15	risk	risk	NN
cord-022594-fx044gcd	160	16	is	be	VBZ
cord-022594-fx044gcd	160	17	even	even	RB
cord-022594-fx044gcd	160	18	higher	high	JJR
cord-022594-fx044gcd	160	19	.	.	.
cord-022594-fx044gcd	161	1	One	one	CD
cord-022594-fx044gcd	161	2	study	study	NN
cord-022594-fx044gcd	161	3	of	of	IN
cord-022594-fx044gcd	161	4	MS	MS	NNP
cord-022594-fx044gcd	161	5	rates	rate	NNS
cord-022594-fx044gcd	161	6	in	in	IN
cord-022594-fx044gcd	161	7	adopted	adopt	VBN
cord-022594-fx044gcd	161	8	relatives	relative	NNS
cord-022594-fx044gcd	161	9	of	of	IN
cord-022594-fx044gcd	161	10	MS	MS	NNP
cord-022594-fx044gcd	161	11	patients	patient	NNS
cord-022594-fx044gcd	161	12	verified	verify	VBD
cord-022594-fx044gcd	161	13	that	that	IN
cord-022594-fx044gcd	161	14	the	the	DT
cord-022594-fx044gcd	161	15	familial	familial	JJ
cord-022594-fx044gcd	161	16	distribution	distribution	NN
cord-022594-fx044gcd	161	17	is	be	VBZ
cord-022594-fx044gcd	161	18	due	due	JJ
cord-022594-fx044gcd	161	19	to	to	IN
cord-022594-fx044gcd	161	20	genetic	genetic	JJ
cord-022594-fx044gcd	161	21	factors	factor	NNS
cord-022594-fx044gcd	161	22	rather	rather	RB
cord-022594-fx044gcd	161	23	than	than	IN
cord-022594-fx044gcd	161	24	shared	share	VBN
cord-022594-fx044gcd	161	25	environment	environment	NN
cord-022594-fx044gcd	161	26	.	.	.
cord-022594-fx044gcd	162	1	20	20	CD
cord-022594-fx044gcd	162	2	Twin	Twin	NNP
cord-022594-fx044gcd	162	3	studies	study	NNS
cord-022594-fx044gcd	162	4	lend	lend	VBP
cord-022594-fx044gcd	162	5	support	support	NN
cord-022594-fx044gcd	162	6	to	to	IN
cord-022594-fx044gcd	162	7	both	both	CC
cord-022594-fx044gcd	162	8	genetic	genetic	JJ
cord-022594-fx044gcd	162	9	and	and	CC
cord-022594-fx044gcd	162	10	environmental	environmental	JJ
cord-022594-fx044gcd	162	11	influences	influence	NNS
cord-022594-fx044gcd	162	12	on	on	IN
cord-022594-fx044gcd	162	13	MS	MS	NNP
cord-022594-fx044gcd	162	14	development	development	NN
cord-022594-fx044gcd	162	15	.	.	.
cord-022594-fx044gcd	163	1	Genetically	genetically	RB
cord-022594-fx044gcd	163	2	identical	identical	JJ
cord-022594-fx044gcd	163	3	monozygotic	monozygotic	JJ
cord-022594-fx044gcd	163	4	twins	twin	NNS
cord-022594-fx044gcd	163	5	are	be	VBP
cord-022594-fx044gcd	163	6	more	more	RBR
cord-022594-fx044gcd	163	7	often	often	RB
cord-022594-fx044gcd	163	8	concordant	concordant	JJ
cord-022594-fx044gcd	163	9	for	for	IN
cord-022594-fx044gcd	163	10	MS	MS	NNP
cord-022594-fx044gcd	163	11	than	than	IN
cord-022594-fx044gcd	163	12	dizygotic	dizygotic	JJ
cord-022594-fx044gcd	163	13	twins	twin	NNS
cord-022594-fx044gcd	163	14	(	(	-LRB-
cord-022594-fx044gcd	163	15	26	26	CD
cord-022594-fx044gcd	163	16	%	%	NN
cord-022594-fx044gcd	163	17	and	and	CC
cord-022594-fx044gcd	163	18	2.4	2.4	CD
cord-022594-fx044gcd	163	19	%	%	NN
cord-022594-fx044gcd	163	20	,	,	,
cord-022594-fx044gcd	163	21	respectively	respectively	RB
cord-022594-fx044gcd	163	22	)	)	-RRB-
cord-022594-fx044gcd	163	23	,	,	,
cord-022594-fx044gcd	163	24	indicating	indicate	VBG
cord-022594-fx044gcd	163	25	a	a	DT
cord-022594-fx044gcd	163	26	genetic	genetic	JJ
cord-022594-fx044gcd	163	27	component	component	NN
cord-022594-fx044gcd	163	28	;	;	:
cord-022594-fx044gcd	163	29	21	21	CD
cord-022594-fx044gcd	163	30	however	however	RB
cord-022594-fx044gcd	163	31	,	,	,
cord-022594-fx044gcd	163	32	even	even	RB
cord-022594-fx044gcd	163	33	after	after	IN
cord-022594-fx044gcd	163	34	following	follow	VBG
cord-022594-fx044gcd	163	35	monozygotic	monozygotic	JJ
cord-022594-fx044gcd	163	36	twins	twin	NNS
cord-022594-fx044gcd	163	37	past	past	IN
cord-022594-fx044gcd	163	38	age	age	NN
cord-022594-fx044gcd	163	39	50	50	CD
cord-022594-fx044gcd	163	40	or	or	CC
cord-022594-fx044gcd	163	41	using	use	VBG
cord-022594-fx044gcd	163	42	MRI	MRI	NNP
cord-022594-fx044gcd	163	43	data	datum	NNS
cord-022594-fx044gcd	163	44	,	,	,
cord-022594-fx044gcd	163	45	less	less	JJR
cord-022594-fx044gcd	163	46	than	than	IN
cord-022594-fx044gcd	163	47	50	50	CD
cord-022594-fx044gcd	163	48	%	%	NN
cord-022594-fx044gcd	163	49	are	be	VBP
cord-022594-fx044gcd	163	50	concordant	concordant	JJ
cord-022594-fx044gcd	163	51	,	,	,
cord-022594-fx044gcd	163	52	suggesting	suggest	VBG
cord-022594-fx044gcd	163	53	a	a	DT
cord-022594-fx044gcd	163	54	role	role	NN
cord-022594-fx044gcd	163	55	for	for	IN
cord-022594-fx044gcd	163	56	environmental	environmental	JJ
cord-022594-fx044gcd	163	57	factors	factor	NNS
cord-022594-fx044gcd	163	58	.	.	.
cord-022594-fx044gcd	164	1	EPIDEMIOLOGY	EPIDEMIOLOGY	NNP
cord-022594-fx044gcd	164	2	AND	and	CC
cord-022594-fx044gcd	164	3	RISK	risk	NN
cord-022594-fx044gcd	164	4	FACTORS	factors	NN
cord-022594-fx044gcd	164	5	.	.	.
cord-022594-fx044gcd	165	1	MS	MS	NNP
cord-022594-fx044gcd	165	2	is	be	VBZ
cord-022594-fx044gcd	165	3	not	not	RB
cord-022594-fx044gcd	165	4	a	a	DT
cord-022594-fx044gcd	165	5	rare	rare	JJ
cord-022594-fx044gcd	165	6	disease	disease	NN
cord-022594-fx044gcd	165	7	.	.	.
cord-022594-fx044gcd	166	1	It	-PRON-	PRP
cord-022594-fx044gcd	166	2	affects	affect	VBZ
cord-022594-fx044gcd	166	3	millions	million	NNS
cord-022594-fx044gcd	166	4	worldwide	worldwide	RB
cord-022594-fx044gcd	166	5	and	and	CC
cord-022594-fx044gcd	166	6	approximately	approximately	RB
cord-022594-fx044gcd	166	7	400,000	400,000	CD
cord-022594-fx044gcd	166	8	in	in	IN
cord-022594-fx044gcd	166	9	the	the	DT
cord-022594-fx044gcd	166	10	United	United	NNP
cord-022594-fx044gcd	166	11	States	States	NNP
cord-022594-fx044gcd	166	12	alone	alone	RB
cord-022594-fx044gcd	166	13	.	.	.
cord-022594-fx044gcd	167	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	167	2	usually	usually	RB
cord-022594-fx044gcd	167	3	begin	begin	VBP
cord-022594-fx044gcd	167	4	during	during	IN
cord-022594-fx044gcd	167	5	young	young	JJ
cord-022594-fx044gcd	167	6	adulthood	adulthood	NN
cord-022594-fx044gcd	167	7	,	,	,
cord-022594-fx044gcd	167	8	with	with	IN
cord-022594-fx044gcd	167	9	the	the	DT
cord-022594-fx044gcd	167	10	peak	peak	JJ
cord-022594-fx044gcd	167	11	onset	onset	NN
cord-022594-fx044gcd	167	12	at	at	IN
cord-022594-fx044gcd	167	13	age	age	NN
cord-022594-fx044gcd	167	14	24	24	CD
cord-022594-fx044gcd	167	15	.	.	.
cord-022594-fx044gcd	168	1	Approximately	approximately	RB
cord-022594-fx044gcd	168	2	0.3	0.3	CD
cord-022594-fx044gcd	168	3	%	%	NN
cord-022594-fx044gcd	168	4	of	of	IN
cord-022594-fx044gcd	168	5	MS	MS	NNP
cord-022594-fx044gcd	168	6	cases	case	NNS
cord-022594-fx044gcd	168	7	are	be	VBP
cord-022594-fx044gcd	168	8	diagnosed	diagnose	VBN
cord-022594-fx044gcd	168	9	before	before	IN
cord-022594-fx044gcd	168	10	age	age	NN
cord-022594-fx044gcd	168	11	15	15	CD
cord-022594-fx044gcd	168	12	.	.	.
cord-022594-fx044gcd	169	1	Women	woman	NNS
cord-022594-fx044gcd	169	2	are	be	VBP
cord-022594-fx044gcd	169	3	affected	affect	VBN
cord-022594-fx044gcd	169	4	nearly	nearly	RB
cord-022594-fx044gcd	169	5	twice	twice	RB
cord-022594-fx044gcd	169	6	as	as	RB
cord-022594-fx044gcd	169	7	often	often	RB
cord-022594-fx044gcd	169	8	as	as	IN
cord-022594-fx044gcd	169	9	men	man	NNS
cord-022594-fx044gcd	169	10	.	.	.
cord-022594-fx044gcd	170	1	MS	MS	NNP
cord-022594-fx044gcd	170	2	has	have	VBZ
cord-022594-fx044gcd	170	3	a	a	DT
cord-022594-fx044gcd	170	4	predilection	predilection	NN
cord-022594-fx044gcd	170	5	for	for	IN
cord-022594-fx044gcd	170	6	whites	white	NNS
cord-022594-fx044gcd	170	7	,	,	,
cord-022594-fx044gcd	170	8	especially	especially	RB
cord-022594-fx044gcd	170	9	those	those	DT
cord-022594-fx044gcd	170	10	of	of	IN
cord-022594-fx044gcd	170	11	northern	northern	JJ
cord-022594-fx044gcd	170	12	European	european	JJ
cord-022594-fx044gcd	170	13	heritage	heritage	NN
cord-022594-fx044gcd	170	14	.	.	.
cord-022594-fx044gcd	171	1	Other	other	JJ
cord-022594-fx044gcd	171	2	races	race	NNS
cord-022594-fx044gcd	171	3	and	and	CC
cord-022594-fx044gcd	171	4	ethnic	ethnic	JJ
cord-022594-fx044gcd	171	5	populations	population	NNS
cord-022594-fx044gcd	171	6	are	be	VBP
cord-022594-fx044gcd	171	7	resistant	resistant	JJ
cord-022594-fx044gcd	171	8	to	to	IN
cord-022594-fx044gcd	171	9	a	a	DT
cord-022594-fx044gcd	171	10	variable	variable	JJ
cord-022594-fx044gcd	171	11	extent	extent	NN
cord-022594-fx044gcd	171	12	.	.	.
cord-022594-fx044gcd	172	1	MS	MS	NNP
cord-022594-fx044gcd	172	2	is	be	VBZ
cord-022594-fx044gcd	172	3	virtually	virtually	RB
cord-022594-fx044gcd	172	4	unknown	unknown	JJ
cord-022594-fx044gcd	172	5	among	among	IN
cord-022594-fx044gcd	172	6	black	black	JJ
cord-022594-fx044gcd	172	7	Africans	Africans	NNPS
cord-022594-fx044gcd	172	8	but	but	CC
cord-022594-fx044gcd	172	9	occurs	occur	VBZ
cord-022594-fx044gcd	172	10	in	in	IN
cord-022594-fx044gcd	172	11	African	African	NNP
cord-022594-fx044gcd	172	12	-	-	HYPH
cord-022594-fx044gcd	172	13	Americans	Americans	NNPS
cord-022594-fx044gcd	172	14	at	at	IN
cord-022594-fx044gcd	172	15	half	half	PDT
cord-022594-fx044gcd	172	16	the	the	DT
cord-022594-fx044gcd	172	17	rate	rate	NN
cord-022594-fx044gcd	172	18	of	of	IN
cord-022594-fx044gcd	172	19	whites	white	NNS
cord-022594-fx044gcd	172	20	,	,	,
cord-022594-fx044gcd	172	21	possibly	possibly	RB
cord-022594-fx044gcd	172	22	due	due	JJ
cord-022594-fx044gcd	172	23	to	to	IN
cord-022594-fx044gcd	172	24	racial	racial	JJ
cord-022594-fx044gcd	172	25	admixture	admixture	NN
cord-022594-fx044gcd	172	26	or	or	CC
cord-022594-fx044gcd	172	27	environmental	environmental	JJ
cord-022594-fx044gcd	172	28	factors	factor	NNS
cord-022594-fx044gcd	172	29	.	.	.
cord-022594-fx044gcd	173	1	MS	MS	NNP
cord-022594-fx044gcd	173	2	is	be	VBZ
cord-022594-fx044gcd	173	3	rare	rare	JJ
cord-022594-fx044gcd	173	4	in	in	IN
cord-022594-fx044gcd	173	5	tropical	tropical	JJ
cord-022594-fx044gcd	173	6	areas	area	NNS
cord-022594-fx044gcd	173	7	,	,	,
cord-022594-fx044gcd	173	8	and	and	CC
cord-022594-fx044gcd	173	9	the	the	DT
cord-022594-fx044gcd	173	10	prevalence	prevalence	NN
cord-022594-fx044gcd	173	11	increases	increase	VBZ
cord-022594-fx044gcd	173	12	proportionally	proportionally	RB
cord-022594-fx044gcd	173	13	to	to	IN
cord-022594-fx044gcd	173	14	the	the	DT
cord-022594-fx044gcd	173	15	distance	distance	NN
cord-022594-fx044gcd	173	16	from	from	IN
cord-022594-fx044gcd	173	17	the	the	DT
cord-022594-fx044gcd	173	18	equator	equator	NN
cord-022594-fx044gcd	173	19	,	,	,
cord-022594-fx044gcd	173	20	excluding	exclude	VBG
cord-022594-fx044gcd	173	21	polar	polar	JJ
cord-022594-fx044gcd	173	22	regions	region	NNS
cord-022594-fx044gcd	173	23	.	.	.
cord-022594-fx044gcd	174	1	The	the	DT
cord-022594-fx044gcd	174	2	prevalence	prevalence	NN
cord-022594-fx044gcd	174	3	is	be	VBZ
cord-022594-fx044gcd	174	4	less	less	JJR
cord-022594-fx044gcd	174	5	than	than	IN
cord-022594-fx044gcd	174	6	5	5	CD
cord-022594-fx044gcd	174	7	cases	case	NNS
cord-022594-fx044gcd	174	8	per	per	IN
cord-022594-fx044gcd	174	9	100,000	100,000	CD
cord-022594-fx044gcd	174	10	in	in	IN
cord-022594-fx044gcd	174	11	tropical	tropical	JJ
cord-022594-fx044gcd	174	12	areas	area	NNS
cord-022594-fx044gcd	174	13	;	;	:
cord-022594-fx044gcd	174	14	in	in	IN
cord-022594-fx044gcd	174	15	high	high	JJ
cord-022594-fx044gcd	174	16	prevalence	prevalence	NN
cord-022594-fx044gcd	174	17	areas	area	NNS
cord-022594-fx044gcd	174	18	it	-PRON-	PRP
cord-022594-fx044gcd	174	19	can	can	MD
cord-022594-fx044gcd	174	20	be	be	VB
cord-022594-fx044gcd	174	21	higher	high	JJR
cord-022594-fx044gcd	174	22	than	than	IN
cord-022594-fx044gcd	174	23	30	30	CD
cord-022594-fx044gcd	174	24	per	per	IN
cord-022594-fx044gcd	174	25	100,000	100,000	CD
cord-022594-fx044gcd	174	26	,	,	,
cord-022594-fx044gcd	174	27	22	22	CD
cord-022594-fx044gcd	174	28	reaching	reach	VBG
cord-022594-fx044gcd	174	29	up	up	IN
cord-022594-fx044gcd	174	30	to	to	TO
cord-022594-fx044gcd	174	31	100	100	CD
cord-022594-fx044gcd	174	32	per	per	IN
cord-022594-fx044gcd	174	33	100,000	100,000	CD
cord-022594-fx044gcd	174	34	in	in	IN
cord-022594-fx044gcd	174	35	selected	select	VBN
cord-022594-fx044gcd	174	36	areas	area	NNS
cord-022594-fx044gcd	174	37	.	.	.
cord-022594-fx044gcd	175	1	Although	although	IN
cord-022594-fx044gcd	175	2	usually	usually	RB
cord-022594-fx044gcd	175	3	interpreted	interpret	VBN
cord-022594-fx044gcd	175	4	as	as	IN
cord-022594-fx044gcd	175	5	the	the	DT
cord-022594-fx044gcd	175	6	effect	effect	NN
cord-022594-fx044gcd	175	7	of	of	IN
cord-022594-fx044gcd	175	8	environmental	environmental	JJ
cord-022594-fx044gcd	175	9	factors	factor	NNS
cord-022594-fx044gcd	175	10	,	,	,
cord-022594-fx044gcd	175	11	the	the	DT
cord-022594-fx044gcd	175	12	prevalence	prevalence	NN
cord-022594-fx044gcd	175	13	gradient	gradient	NN
cord-022594-fx044gcd	175	14	is	be	VBZ
cord-022594-fx044gcd	175	15	at	at	IN
cord-022594-fx044gcd	175	16	least	least	JJS
cord-022594-fx044gcd	175	17	partially	partially	RB
cord-022594-fx044gcd	175	18	due	due	JJ
cord-022594-fx044gcd	175	19	to	to	IN
cord-022594-fx044gcd	175	20	racial	racial	JJ
cord-022594-fx044gcd	175	21	susceptibility	susceptibility	NN
cord-022594-fx044gcd	175	22	.	.	.
cord-022594-fx044gcd	176	1	23	23	CD
cord-022594-fx044gcd	177	1	Perhaps	perhaps	RB
cord-022594-fx044gcd	177	2	the	the	DT
cord-022594-fx044gcd	177	3	most	most	RBS
cord-022594-fx044gcd	177	4	incriminating	incriminating	JJ
cord-022594-fx044gcd	177	5	evidence	evidence	NN
cord-022594-fx044gcd	177	6	for	for	IN
cord-022594-fx044gcd	177	7	the	the	DT
cord-022594-fx044gcd	177	8	role	role	NN
cord-022594-fx044gcd	177	9	of	of	IN
cord-022594-fx044gcd	177	10	environmental	environmental	JJ
cord-022594-fx044gcd	177	11	factors	factor	NNS
cord-022594-fx044gcd	177	12	in	in	IN
cord-022594-fx044gcd	177	13	the	the	DT
cord-022594-fx044gcd	177	14	development	development	NN
cord-022594-fx044gcd	177	15	of	of	IN
cord-022594-fx044gcd	177	16	MS	MS	NNP
cord-022594-fx044gcd	177	17	is	be	VBZ
cord-022594-fx044gcd	177	18	the	the	DT
cord-022594-fx044gcd	177	19	changing	change	VBG
cord-022594-fx044gcd	177	20	risk	risk	NN
cord-022594-fx044gcd	177	21	with	with	IN
cord-022594-fx044gcd	177	22	migration	migration	NN
cord-022594-fx044gcd	177	23	and	and	CC
cord-022594-fx044gcd	177	24	the	the	DT
cord-022594-fx044gcd	177	25	occurrence	occurrence	NN
cord-022594-fx044gcd	177	26	of	of	IN
cord-022594-fx044gcd	177	27	MS	MS	NNP
cord-022594-fx044gcd	177	28	clusters	cluster	NNS
cord-022594-fx044gcd	177	29	and	and	CC
cord-022594-fx044gcd	177	30	epidemics	epidemic	NNS
cord-022594-fx044gcd	177	31	.	.	.
cord-022594-fx044gcd	178	1	Immigrant	immigrant	JJ
cord-022594-fx044gcd	178	2	populations	population	NNS
cord-022594-fx044gcd	178	3	tend	tend	VBP
cord-022594-fx044gcd	178	4	to	to	TO
cord-022594-fx044gcd	178	5	acquire	acquire	VB
cord-022594-fx044gcd	178	6	the	the	DT
cord-022594-fx044gcd	178	7	MS	MS	NNP
cord-022594-fx044gcd	178	8	risk	risk	NN
cord-022594-fx044gcd	178	9	inherent	inherent	JJ
cord-022594-fx044gcd	178	10	to	to	IN
cord-022594-fx044gcd	178	11	their	-PRON-	PRP$
cord-022594-fx044gcd	178	12	new	new	JJ
cord-022594-fx044gcd	178	13	place	place	NN
cord-022594-fx044gcd	178	14	of	of	IN
cord-022594-fx044gcd	178	15	residence	residence	NN
cord-022594-fx044gcd	178	16	.	.	.
cord-022594-fx044gcd	179	1	Migration	migration	NN
cord-022594-fx044gcd	179	2	from	from	IN
cord-022594-fx044gcd	179	3	high	high	JJ
cord-022594-fx044gcd	179	4	to	to	IN
cord-022594-fx044gcd	179	5	low	low	JJ
cord-022594-fx044gcd	179	6	prevalence	prevalence	NN
cord-022594-fx044gcd	179	7	before	before	IN
cord-022594-fx044gcd	179	8	the	the	DT
cord-022594-fx044gcd	179	9	age	age	NN
cord-022594-fx044gcd	179	10	of	of	IN
cord-022594-fx044gcd	179	11	15	15	CD
cord-022594-fx044gcd	179	12	lowers	lower	VBZ
cord-022594-fx044gcd	179	13	the	the	DT
cord-022594-fx044gcd	179	14	MS	MS	NNP
cord-022594-fx044gcd	179	15	risk	risk	NN
cord-022594-fx044gcd	179	16	,	,	,
cord-022594-fx044gcd	179	17	whereas	whereas	IN
cord-022594-fx044gcd	179	18	migration	migration	NN
cord-022594-fx044gcd	179	19	after	after	IN
cord-022594-fx044gcd	179	20	this	this	DT
cord-022594-fx044gcd	179	21	age	age	NN
cord-022594-fx044gcd	179	22	does	do	VBZ
cord-022594-fx044gcd	179	23	not	not	RB
cord-022594-fx044gcd	179	24	affect	affect	VB
cord-022594-fx044gcd	179	25	risk	risk	NN
cord-022594-fx044gcd	179	26	.	.	.
cord-022594-fx044gcd	180	1	18	18	CD
cord-022594-fx044gcd	180	2	Migration	migration	NN
cord-022594-fx044gcd	180	3	from	from	IN
cord-022594-fx044gcd	180	4	low	low	JJ
cord-022594-fx044gcd	180	5	to	to	IN
cord-022594-fx044gcd	180	6	high	high	JJ
cord-022594-fx044gcd	180	7	prevalence	prevalence	NN
cord-022594-fx044gcd	180	8	areas	area	NNS
cord-022594-fx044gcd	180	9	increases	increase	VBZ
cord-022594-fx044gcd	180	10	the	the	DT
cord-022594-fx044gcd	180	11	risk	risk	NN
cord-022594-fx044gcd	180	12	of	of	IN
cord-022594-fx044gcd	180	13	MS	MS	NNP
cord-022594-fx044gcd	180	14	,	,	,
cord-022594-fx044gcd	180	15	but	but	CC
cord-022594-fx044gcd	180	16	the	the	DT
cord-022594-fx044gcd	180	17	effect	effect	NN
cord-022594-fx044gcd	180	18	of	of	IN
cord-022594-fx044gcd	180	19	age	age	NN
cord-022594-fx044gcd	180	20	is	be	VBZ
cord-022594-fx044gcd	180	21	less	less	RBR
cord-022594-fx044gcd	180	22	clear	clear	JJ
cord-022594-fx044gcd	180	23	.	.	.
cord-022594-fx044gcd	181	1	Many	many	JJ
cord-022594-fx044gcd	181	2	clusters	cluster	NNS
cord-022594-fx044gcd	181	3	of	of	IN
cord-022594-fx044gcd	181	4	MS	MS	NNP
cord-022594-fx044gcd	181	5	have	have	VBP
cord-022594-fx044gcd	181	6	been	be	VBN
cord-022594-fx044gcd	181	7	reported	report	VBN
cord-022594-fx044gcd	181	8	.	.	.
cord-022594-fx044gcd	182	1	24	24	CD
cord-022594-fx044gcd	182	2	,	,	,
cord-022594-fx044gcd	182	3	25	25	CD
cord-022594-fx044gcd	182	4	The	the	DT
cord-022594-fx044gcd	182	5	occurrences	occurrence	NNS
cord-022594-fx044gcd	182	6	of	of	IN
cord-022594-fx044gcd	182	7	MS	MS	NNP
cord-022594-fx044gcd	182	8	epidemics	epidemic	NNS
cord-022594-fx044gcd	182	9	in	in	IN
cord-022594-fx044gcd	182	10	Iceland	Iceland	NNP
cord-022594-fx044gcd	182	11	and	and	CC
cord-022594-fx044gcd	182	12	the	the	DT
cord-022594-fx044gcd	182	13	Faroe	Faroe	NNP
cord-022594-fx044gcd	182	14	Islands	Islands	NNPS
cord-022594-fx044gcd	182	15	have	have	VBP
cord-022594-fx044gcd	182	16	been	be	VBN
cord-022594-fx044gcd	182	17	proposed	propose	VBN
cord-022594-fx044gcd	182	18	to	to	TO
cord-022594-fx044gcd	182	19	be	be	VB
cord-022594-fx044gcd	182	20	the	the	DT
cord-022594-fx044gcd	182	21	result	result	NN
cord-022594-fx044gcd	182	22	of	of	IN
cord-022594-fx044gcd	182	23	exposure	exposure	NN
cord-022594-fx044gcd	182	24	to	to	IN
cord-022594-fx044gcd	182	25	a	a	DT
cord-022594-fx044gcd	182	26	pathogen	pathogen	NN
cord-022594-fx044gcd	182	27	brought	bring	VBN
cord-022594-fx044gcd	182	28	by	by	IN
cord-022594-fx044gcd	182	29	British	british	JJ
cord-022594-fx044gcd	182	30	troops	troop	NNS
cord-022594-fx044gcd	182	31	during	during	IN
cord-022594-fx044gcd	182	32	their	-PRON-	PRP$
cord-022594-fx044gcd	182	33	occupation	occupation	NN
cord-022594-fx044gcd	182	34	in	in	IN
cord-022594-fx044gcd	182	35	World	World	NNP
cord-022594-fx044gcd	182	36	War	War	NNP
cord-022594-fx044gcd	182	37	II	II	NNP
cord-022594-fx044gcd	182	38	.	.	.
cord-022594-fx044gcd	183	1	Other	other	JJ
cord-022594-fx044gcd	183	2	environmental	environmental	JJ
cord-022594-fx044gcd	183	3	factors	factor	NNS
cord-022594-fx044gcd	183	4	associated	associate	VBN
cord-022594-fx044gcd	183	5	with	with	IN
cord-022594-fx044gcd	183	6	the	the	DT
cord-022594-fx044gcd	183	7	development	development	NN
cord-022594-fx044gcd	183	8	of	of	IN
cord-022594-fx044gcd	183	9	MS	MS	NNP
cord-022594-fx044gcd	183	10	include	include	VBP
cord-022594-fx044gcd	183	11	cigarette	cigarette	NN
cord-022594-fx044gcd	183	12	smoking	smoking	NN
cord-022594-fx044gcd	183	13	(	(	-LRB-
cord-022594-fx044gcd	183	14	odds	odd	NNS
cord-022594-fx044gcd	183	15	ratio	ratio	NN
cord-022594-fx044gcd	183	16	of	of	IN
cord-022594-fx044gcd	183	17	1.81	1.81	CD
cord-022594-fx044gcd	183	18	,	,	,
cord-022594-fx044gcd	183	19	CI	CI	NNP
cord-022594-fx044gcd	183	20	:	:	:
cord-022594-fx044gcd	183	21	1.1	1.1	CD
cord-022594-fx044gcd	183	22	-	-	SYM
cord-022594-fx044gcd	183	23	2.9	2.9	CD
cord-022594-fx044gcd	183	24	)	)	-RRB-
cord-022594-fx044gcd	183	25	,	,	,
cord-022594-fx044gcd	183	26	animal	animal	NN
cord-022594-fx044gcd	183	27	fat	fat	NN
cord-022594-fx044gcd	183	28	intake	intake	NN
cord-022594-fx044gcd	183	29	,	,	,
cord-022594-fx044gcd	183	30	and	and	CC
cord-022594-fx044gcd	183	31	deficiency	deficiency	NN
cord-022594-fx044gcd	183	32	of	of	IN
cord-022594-fx044gcd	183	33	vitamin	vitamin	NN
cord-022594-fx044gcd	183	34	D.	D.	NNP
cord-022594-fx044gcd	183	35	26	26	CD
cord-022594-fx044gcd	183	36	,	,	,
cord-022594-fx044gcd	183	37	27	27	CD
cord-022594-fx044gcd	183	38	Epidemiological	epidemiological	JJ
cord-022594-fx044gcd	183	39	data	datum	NNS
cord-022594-fx044gcd	183	40	support	support	VBP
cord-022594-fx044gcd	183	41	the	the	DT
cord-022594-fx044gcd	183	42	view	view	NN
cord-022594-fx044gcd	183	43	that	that	IN
cord-022594-fx044gcd	183	44	MS	MS	NNP
cord-022594-fx044gcd	183	45	is	be	VBZ
cord-022594-fx044gcd	183	46	caused	cause	VBN
cord-022594-fx044gcd	183	47	or	or	CC
cord-022594-fx044gcd	183	48	triggered	trigger	VBN
cord-022594-fx044gcd	183	49	by	by	IN
cord-022594-fx044gcd	183	50	an	an	DT
cord-022594-fx044gcd	183	51	environmental	environmental	JJ
cord-022594-fx044gcd	183	52	factor	factor	NN
cord-022594-fx044gcd	183	53	in	in	IN
cord-022594-fx044gcd	183	54	persons	person	NNS
cord-022594-fx044gcd	183	55	who	who	WP
cord-022594-fx044gcd	183	56	are	be	VBP
cord-022594-fx044gcd	183	57	genetically	genetically	RB
cord-022594-fx044gcd	183	58	susceptible	susceptible	JJ
cord-022594-fx044gcd	183	59	.	.	.
cord-022594-fx044gcd	184	1	The	the	DT
cord-022594-fx044gcd	184	2	familial	familial	JJ
cord-022594-fx044gcd	184	3	frequency	frequency	NN
cord-022594-fx044gcd	184	4	and	and	CC
cord-022594-fx044gcd	184	5	distribution	distribution	NN
cord-022594-fx044gcd	184	6	implies	imply	VBZ
cord-022594-fx044gcd	184	7	that	that	IN
cord-022594-fx044gcd	184	8	several	several	JJ
cord-022594-fx044gcd	184	9	genes	gene	NNS
cord-022594-fx044gcd	184	10	contribute	contribute	VBP
cord-022594-fx044gcd	184	11	to	to	IN
cord-022594-fx044gcd	184	12	susceptibility	susceptibility	NN
cord-022594-fx044gcd	184	13	,	,	,
cord-022594-fx044gcd	184	14	and	and	CC
cord-022594-fx044gcd	184	15	this	this	DT
cord-022594-fx044gcd	184	16	is	be	VBZ
cord-022594-fx044gcd	184	17	consistent	consistent	JJ
cord-022594-fx044gcd	184	18	with	with	IN
cord-022594-fx044gcd	184	19	the	the	DT
cord-022594-fx044gcd	184	20	low	low	JJ
cord-022594-fx044gcd	184	21	relative	relative	JJ
cord-022594-fx044gcd	184	22	risk	risk	NN
cord-022594-fx044gcd	184	23	conferred	confer	VBN
cord-022594-fx044gcd	184	24	by	by	IN
cord-022594-fx044gcd	184	25	the	the	DT
cord-022594-fx044gcd	184	26	genetic	genetic	JJ
cord-022594-fx044gcd	184	27	loci	locus	NNS
cord-022594-fx044gcd	184	28	studied	study	VBN
cord-022594-fx044gcd	184	29	so	so	RB
cord-022594-fx044gcd	184	30	far	far	RB
cord-022594-fx044gcd	184	31	.	.	.
cord-022594-fx044gcd	185	1	Data	datum	NNS
cord-022594-fx044gcd	185	2	from	from	IN
cord-022594-fx044gcd	185	3	clusters	cluster	NNS
cord-022594-fx044gcd	185	4	,	,	,
cord-022594-fx044gcd	185	5	migration	migration	NN
cord-022594-fx044gcd	185	6	studies	study	NNS
cord-022594-fx044gcd	185	7	,	,	,
cord-022594-fx044gcd	185	8	and	and	CC
cord-022594-fx044gcd	185	9	family	family	NN
cord-022594-fx044gcd	185	10	studies	study	NNS
cord-022594-fx044gcd	185	11	reveal	reveal	VBP
cord-022594-fx044gcd	185	12	that	that	IN
cord-022594-fx044gcd	185	13	there	there	EX
cord-022594-fx044gcd	185	14	is	be	VBZ
cord-022594-fx044gcd	185	15	a	a	DT
cord-022594-fx044gcd	185	16	latent	latent	JJ
cord-022594-fx044gcd	185	17	period	period	NN
cord-022594-fx044gcd	185	18	of	of	IN
cord-022594-fx044gcd	185	19	some	some	DT
cord-022594-fx044gcd	185	20	20	20	CD
cord-022594-fx044gcd	185	21	years	year	NNS
cord-022594-fx044gcd	185	22	between	between	IN
cord-022594-fx044gcd	185	23	exposure	exposure	NN
cord-022594-fx044gcd	185	24	to	to	IN
cord-022594-fx044gcd	185	25	the	the	DT
cord-022594-fx044gcd	185	26	environmental	environmental	JJ
cord-022594-fx044gcd	185	27	factor	factor	NN
cord-022594-fx044gcd	185	28	and	and	CC
cord-022594-fx044gcd	185	29	the	the	DT
cord-022594-fx044gcd	185	30	development	development	NN
cord-022594-fx044gcd	185	31	of	of	IN
cord-022594-fx044gcd	185	32	clinical	clinical	JJ
cord-022594-fx044gcd	185	33	symptoms	symptom	NNS
cord-022594-fx044gcd	185	34	and	and	CC
cord-022594-fx044gcd	185	35	that	that	IN
cord-022594-fx044gcd	185	36	the	the	DT
cord-022594-fx044gcd	185	37	age	age	NN
cord-022594-fx044gcd	185	38	at	at	IN
cord-022594-fx044gcd	185	39	exposure	exposure	NN
cord-022594-fx044gcd	185	40	is	be	VBZ
cord-022594-fx044gcd	185	41	around	around	RB
cord-022594-fx044gcd	185	42	15	15	CD
cord-022594-fx044gcd	185	43	,	,	,
cord-022594-fx044gcd	185	44	the	the	DT
cord-022594-fx044gcd	185	45	putative	putative	JJ
cord-022594-fx044gcd	185	46	age	age	NN
cord-022594-fx044gcd	185	47	at	at	IN
cord-022594-fx044gcd	185	48	acquisition	acquisition	NN
cord-022594-fx044gcd	185	49	.	.	.
cord-022594-fx044gcd	186	1	The	the	DT
cord-022594-fx044gcd	186	2	precise	precise	JJ
cord-022594-fx044gcd	186	3	environmental	environmental	JJ
cord-022594-fx044gcd	186	4	events	event	NNS
cord-022594-fx044gcd	186	5	that	that	WDT
cord-022594-fx044gcd	186	6	lead	lead	VBP
cord-022594-fx044gcd	186	7	to	to	IN
cord-022594-fx044gcd	186	8	CNS	CNS	NNP
cord-022594-fx044gcd	186	9	demyelination	demyelination	NN
cord-022594-fx044gcd	186	10	are	be	VBP
cord-022594-fx044gcd	186	11	uncertain	uncertain	JJ
cord-022594-fx044gcd	186	12	.	.	.
cord-022594-fx044gcd	187	1	Viral	viral	JJ
cord-022594-fx044gcd	187	2	infection	infection	NN
cord-022594-fx044gcd	187	3	is	be	VBZ
cord-022594-fx044gcd	187	4	the	the	DT
cord-022594-fx044gcd	187	5	most	most	RBS
cord-022594-fx044gcd	187	6	plausible	plausible	JJ
cord-022594-fx044gcd	187	7	,	,	,
cord-022594-fx044gcd	187	8	but	but	CC
cord-022594-fx044gcd	187	9	because	because	IN
cord-022594-fx044gcd	187	10	of	of	IN
cord-022594-fx044gcd	187	11	the	the	DT
cord-022594-fx044gcd	187	12	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	187	13	elevation	elevation	NN
cord-022594-fx044gcd	187	14	of	of	IN
cord-022594-fx044gcd	187	15	viral	viral	JJ
cord-022594-fx044gcd	187	16	titers	titer	NNS
cord-022594-fx044gcd	187	17	and	and	CC
cord-022594-fx044gcd	187	18	long	long	JJ
cord-022594-fx044gcd	187	19	latent	latent	JJ
cord-022594-fx044gcd	187	20	period	period	NN
cord-022594-fx044gcd	187	21	,	,	,
cord-022594-fx044gcd	187	22	there	there	EX
cord-022594-fx044gcd	187	23	is	be	VBZ
cord-022594-fx044gcd	187	24	little	little	JJ
cord-022594-fx044gcd	187	25	direct	direct	JJ
cord-022594-fx044gcd	187	26	evidence	evidence	NN
cord-022594-fx044gcd	187	27	.	.	.
cord-022594-fx044gcd	188	1	Minor	minor	JJ
cord-022594-fx044gcd	188	2	respiratory	respiratory	JJ
cord-022594-fx044gcd	188	3	infections	infection	NNS
cord-022594-fx044gcd	188	4	precede	precede	VBP
cord-022594-fx044gcd	188	5	27	27	CD
cord-022594-fx044gcd	188	6	%	%	NN
cord-022594-fx044gcd	188	7	of	of	IN
cord-022594-fx044gcd	188	8	relapses	relapse	NNS
cord-022594-fx044gcd	188	9	in	in	IN
cord-022594-fx044gcd	188	10	patients	patient	NNS
cord-022594-fx044gcd	188	11	with	with	IN
cord-022594-fx044gcd	188	12	established	establish	VBN
cord-022594-fx044gcd	188	13	MS	MS	NNP
cord-022594-fx044gcd	188	14	.	.	.
cord-022594-fx044gcd	189	1	Measles	measles	NN
cord-022594-fx044gcd	189	2	infection	infection	NN
cord-022594-fx044gcd	189	3	was	be	VBD
cord-022594-fx044gcd	189	4	found	find	VBN
cord-022594-fx044gcd	189	5	to	to	TO
cord-022594-fx044gcd	189	6	have	have	VB
cord-022594-fx044gcd	189	7	occurred	occur	VBN
cord-022594-fx044gcd	189	8	at	at	IN
cord-022594-fx044gcd	189	9	a	a	DT
cord-022594-fx044gcd	189	10	later	later	JJ
cord-022594-fx044gcd	189	11	age	age	NN
cord-022594-fx044gcd	189	12	in	in	IN
cord-022594-fx044gcd	189	13	MS	MS	NNP
cord-022594-fx044gcd	189	14	patients	patient	NNS
cord-022594-fx044gcd	189	15	than	than	IN
cord-022594-fx044gcd	189	16	control	control	NN
cord-022594-fx044gcd	189	17	subjects	subject	NNS
cord-022594-fx044gcd	189	18	,	,	,
cord-022594-fx044gcd	189	19	although	although	IN
cord-022594-fx044gcd	189	20	the	the	DT
cord-022594-fx044gcd	189	21	incidence	incidence	NN
cord-022594-fx044gcd	189	22	of	of	IN
cord-022594-fx044gcd	189	23	MS	MS	NNP
cord-022594-fx044gcd	189	24	has	have	VBZ
cord-022594-fx044gcd	189	25	not	not	RB
cord-022594-fx044gcd	189	26	been	be	VBN
cord-022594-fx044gcd	189	27	reduced	reduce	VBN
cord-022594-fx044gcd	189	28	by	by	IN
cord-022594-fx044gcd	189	29	immunization	immunization	NN
cord-022594-fx044gcd	189	30	against	against	IN
cord-022594-fx044gcd	189	31	measles	measle	NNS
cord-022594-fx044gcd	189	32	.	.	.
cord-022594-fx044gcd	190	1	Head	Head	NNP
cord-022594-fx044gcd	190	2	injury	injury	NN
cord-022594-fx044gcd	190	3	and	and	CC
cord-022594-fx044gcd	190	4	trauma	trauma	NN
cord-022594-fx044gcd	190	5	have	have	VBP
cord-022594-fx044gcd	190	6	received	receive	VBN
cord-022594-fx044gcd	190	7	attention	attention	NN
cord-022594-fx044gcd	190	8	as	as	IN
cord-022594-fx044gcd	190	9	putative	putative	JJ
cord-022594-fx044gcd	190	10	triggering	trigger	VBG
cord-022594-fx044gcd	190	11	events	event	NNS
cord-022594-fx044gcd	190	12	,	,	,
cord-022594-fx044gcd	190	13	but	but	CC
cord-022594-fx044gcd	190	14	cohort	cohort	NN
cord-022594-fx044gcd	190	15	studies	study	NNS
cord-022594-fx044gcd	190	16	have	have	VBP
cord-022594-fx044gcd	190	17	not	not	RB
cord-022594-fx044gcd	190	18	verified	verify	VBN
cord-022594-fx044gcd	190	19	any	any	DT
cord-022594-fx044gcd	190	20	link	link	NN
cord-022594-fx044gcd	190	21	.	.	.
cord-022594-fx044gcd	191	1	Pregnancy	pregnancy	NN
cord-022594-fx044gcd	191	2	does	do	VBZ
cord-022594-fx044gcd	191	3	not	not	RB
cord-022594-fx044gcd	191	4	alter	alter	VB
cord-022594-fx044gcd	191	5	the	the	DT
cord-022594-fx044gcd	191	6	risk	risk	NN
cord-022594-fx044gcd	191	7	of	of	IN
cord-022594-fx044gcd	191	8	developing	develop	VBG
cord-022594-fx044gcd	191	9	MS	MS	NNP
cord-022594-fx044gcd	191	10	,	,	,
cord-022594-fx044gcd	191	11	but	but	CC
cord-022594-fx044gcd	191	12	it	-PRON-	PRP
cord-022594-fx044gcd	191	13	does	do	VBZ
cord-022594-fx044gcd	191	14	seem	seem	VB
cord-022594-fx044gcd	191	15	to	to	TO
cord-022594-fx044gcd	191	16	influence	influence	VB
cord-022594-fx044gcd	191	17	disease	disease	NN
cord-022594-fx044gcd	191	18	activity	activity	NN
cord-022594-fx044gcd	191	19	.	.	.
cord-022594-fx044gcd	192	1	The	the	DT
cord-022594-fx044gcd	192	2	annualized	annualize	VBN
cord-022594-fx044gcd	192	3	relapse	relapse	NN
cord-022594-fx044gcd	192	4	rate	rate	NN
cord-022594-fx044gcd	192	5	drops	drop	NNS
cord-022594-fx044gcd	192	6	from	from	IN
cord-022594-fx044gcd	192	7	approximately	approximately	RB
cord-022594-fx044gcd	192	8	0.56	0.56	CD
cord-022594-fx044gcd	192	9	to	to	IN
cord-022594-fx044gcd	192	10	0.12	0.12	CD
cord-022594-fx044gcd	192	11	by	by	IN
cord-022594-fx044gcd	192	12	the	the	DT
cord-022594-fx044gcd	192	13	third	third	JJ
cord-022594-fx044gcd	192	14	trimester	trimester	NN
cord-022594-fx044gcd	192	15	,	,	,
cord-022594-fx044gcd	192	16	but	but	CC
cord-022594-fx044gcd	192	17	this	this	DT
cord-022594-fx044gcd	192	18	is	be	VBZ
cord-022594-fx044gcd	192	19	offset	offset	VBN
cord-022594-fx044gcd	192	20	by	by	IN
cord-022594-fx044gcd	192	21	an	an	DT
cord-022594-fx044gcd	192	22	increase	increase	NN
cord-022594-fx044gcd	192	23	to	to	IN
cord-022594-fx044gcd	192	24	1.2	1.2	CD
cord-022594-fx044gcd	192	25	in	in	IN
cord-022594-fx044gcd	192	26	the	the	DT
cord-022594-fx044gcd	192	27	first	first	JJ
cord-022594-fx044gcd	192	28	3	3	CD
cord-022594-fx044gcd	192	29	postpartum	postpartum	NN
cord-022594-fx044gcd	192	30	months	month	NNS
cord-022594-fx044gcd	192	31	.	.	.
cord-022594-fx044gcd	193	1	Most	Most	JJS
cord-022594-fx044gcd	193	2	studies	study	NNS
cord-022594-fx044gcd	193	3	have	have	VBP
cord-022594-fx044gcd	193	4	found	find	VBN
cord-022594-fx044gcd	193	5	no	no	DT
cord-022594-fx044gcd	193	6	longterm	longterm	JJ
cord-022594-fx044gcd	193	7	effects	effect	NNS
cord-022594-fx044gcd	193	8	of	of	IN
cord-022594-fx044gcd	193	9	pregnancy	pregnancy	NN
cord-022594-fx044gcd	193	10	on	on	IN
cord-022594-fx044gcd	193	11	the	the	DT
cord-022594-fx044gcd	193	12	prognosis	prognosis	NN
cord-022594-fx044gcd	193	13	for	for	IN
cord-022594-fx044gcd	193	14	progression	progression	NN
cord-022594-fx044gcd	193	15	or	or	CC
cord-022594-fx044gcd	193	16	disability	disability	NN
cord-022594-fx044gcd	193	17	,	,	,
cord-022594-fx044gcd	193	18	although	although	IN
cord-022594-fx044gcd	193	19	one	one	PRP
cord-022594-fx044gcd	193	20	did	do	VBD
cord-022594-fx044gcd	193	21	report	report	VB
cord-022594-fx044gcd	193	22	a	a	DT
cord-022594-fx044gcd	193	23	favorable	favorable	JJ
cord-022594-fx044gcd	193	24	effect	effect	NN
cord-022594-fx044gcd	193	25	.	.	.
cord-022594-fx044gcd	194	1	28	28	CD
cord-022594-fx044gcd	195	1	A	a	DT
cord-022594-fx044gcd	195	2	multitude	multitude	NN
cord-022594-fx044gcd	195	3	of	of	IN
cord-022594-fx044gcd	195	4	other	other	JJ
cord-022594-fx044gcd	195	5	environmental	environmental	JJ
cord-022594-fx044gcd	195	6	factors	factor	NNS
cord-022594-fx044gcd	195	7	have	have	VBP
cord-022594-fx044gcd	195	8	been	be	VBN
cord-022594-fx044gcd	195	9	suspected	suspect	VBN
cord-022594-fx044gcd	195	10	to	to	TO
cord-022594-fx044gcd	195	11	alter	alter	VB
cord-022594-fx044gcd	195	12	the	the	DT
cord-022594-fx044gcd	195	13	risk	risk	NN
cord-022594-fx044gcd	195	14	for	for	IN
cord-022594-fx044gcd	195	15	MS	MS	NNP
cord-022594-fx044gcd	195	16	(	(	-LRB-
cord-022594-fx044gcd	195	17	cold	cold	JJ
cord-022594-fx044gcd	195	18	climate	climate	NN
cord-022594-fx044gcd	195	19	,	,	,
cord-022594-fx044gcd	195	20	precipitation	precipitation	NN
cord-022594-fx044gcd	195	21	,	,	,
cord-022594-fx044gcd	195	22	amount	amount	NN
cord-022594-fx044gcd	195	23	of	of	IN
cord-022594-fx044gcd	195	24	peat	peat	NN
cord-022594-fx044gcd	195	25	in	in	IN
cord-022594-fx044gcd	195	26	the	the	DT
cord-022594-fx044gcd	195	27	soil	soil	NN
cord-022594-fx044gcd	195	28	,	,	,
cord-022594-fx044gcd	195	29	exposure	exposure	NN
cord-022594-fx044gcd	195	30	to	to	IN
cord-022594-fx044gcd	195	31	dogs	dog	NNS
cord-022594-fx044gcd	195	32	,	,	,
cord-022594-fx044gcd	195	33	and	and	CC
cord-022594-fx044gcd	195	34	consumption	consumption	NN
cord-022594-fx044gcd	195	35	of	of	IN
cord-022594-fx044gcd	195	36	meat	meat	NN
cord-022594-fx044gcd	195	37	,	,	,
cord-022594-fx044gcd	195	38	processed	process	VBN
cord-022594-fx044gcd	195	39	meat	meat	NN
cord-022594-fx044gcd	195	40	,	,	,
cord-022594-fx044gcd	195	41	and	and	CC
cord-022594-fx044gcd	195	42	dairy	dairy	NN
cord-022594-fx044gcd	195	43	products	product	NNS
cord-022594-fx044gcd	195	44	)	)	-RRB-
cord-022594-fx044gcd	195	45	,	,	,
cord-022594-fx044gcd	195	46	but	but	CC
cord-022594-fx044gcd	195	47	none	none	NN
cord-022594-fx044gcd	195	48	has	have	VBZ
cord-022594-fx044gcd	195	49	been	be	VBN
cord-022594-fx044gcd	195	50	verified	verify	VBN
cord-022594-fx044gcd	195	51	to	to	TO
cord-022594-fx044gcd	195	52	be	be	VB
cord-022594-fx044gcd	195	53	an	an	DT
cord-022594-fx044gcd	195	54	independent	independent	JJ
cord-022594-fx044gcd	195	55	risk	risk	NN
cord-022594-fx044gcd	195	56	factor	factor	NN
cord-022594-fx044gcd	195	57	.	.	.
cord-022594-fx044gcd	196	1	MS	MS	NNP
cord-022594-fx044gcd	196	2	can	can	MD
cord-022594-fx044gcd	196	3	cause	cause	VB
cord-022594-fx044gcd	196	4	a	a	DT
cord-022594-fx044gcd	196	5	wide	wide	JJ
cord-022594-fx044gcd	196	6	variety	variety	NN
cord-022594-fx044gcd	196	7	of	of	IN
cord-022594-fx044gcd	196	8	clinical	clinical	JJ
cord-022594-fx044gcd	196	9	features	feature	NNS
cord-022594-fx044gcd	196	10	.	.	.
cord-022594-fx044gcd	197	1	Many	many	JJ
cord-022594-fx044gcd	197	2	signs	sign	NNS
cord-022594-fx044gcd	197	3	and	and	CC
cord-022594-fx044gcd	197	4	symptoms	symptom	NNS
cord-022594-fx044gcd	197	5	are	be	VBP
cord-022594-fx044gcd	197	6	characteristic	characteristic	JJ
cord-022594-fx044gcd	197	7	,	,	,
cord-022594-fx044gcd	197	8	and	and	CC
cord-022594-fx044gcd	197	9	a	a	DT
cord-022594-fx044gcd	197	10	few	few	JJ
cord-022594-fx044gcd	197	11	are	be	VBP
cord-022594-fx044gcd	197	12	virtually	virtually	RB
cord-022594-fx044gcd	197	13	pathognomonic	pathognomonic	JJ
cord-022594-fx044gcd	197	14	for	for	IN
cord-022594-fx044gcd	197	15	the	the	DT
cord-022594-fx044gcd	197	16	disorder	disorder	NN
cord-022594-fx044gcd	197	17	.	.	.
cord-022594-fx044gcd	198	1	Conversely	conversely	RB
cord-022594-fx044gcd	198	2	,	,	,
cord-022594-fx044gcd	198	3	some	some	DT
cord-022594-fx044gcd	198	4	symptoms	symptom	NNS
cord-022594-fx044gcd	198	5	are	be	VBP
cord-022594-fx044gcd	198	6	atypical	atypical	JJ
cord-022594-fx044gcd	198	7	and	and	CC
cord-022594-fx044gcd	198	8	some	some	DT
cord-022594-fx044gcd	198	9	are	be	VBP
cord-022594-fx044gcd	198	10	so	so	RB
cord-022594-fx044gcd	198	11	rare	rare	JJ
cord-022594-fx044gcd	198	12	as	as	IN
cord-022594-fx044gcd	198	13	to	to	TO
cord-022594-fx044gcd	198	14	suggest	suggest	VB
cord-022594-fx044gcd	198	15	a	a	DT
cord-022594-fx044gcd	198	16	different	different	JJ
cord-022594-fx044gcd	198	17	diagnosis	diagnosis	NN
cord-022594-fx044gcd	198	18	(	(	-LRB-
cord-022594-fx044gcd	198	19	Table	table	NN
cord-022594-fx044gcd	198	20	48	48	CD
cord-022594-fx044gcd	198	21	-2	-2	CD
cord-022594-fx044gcd	198	22	)	)	-RRB-
cord-022594-fx044gcd	198	23	.	.	.
cord-022594-fx044gcd	199	1	The	the	DT
cord-022594-fx044gcd	199	2	course	course	NN
cord-022594-fx044gcd	199	3	of	of	IN
cord-022594-fx044gcd	199	4	the	the	DT
cord-022594-fx044gcd	199	5	illness	illness	NN
cord-022594-fx044gcd	199	6	is	be	VBZ
cord-022594-fx044gcd	199	7	also	also	RB
cord-022594-fx044gcd	199	8	variable	variable	JJ
cord-022594-fx044gcd	199	9	,	,	,
cord-022594-fx044gcd	199	10	but	but	CC
cord-022594-fx044gcd	199	11	it	-PRON-	PRP
cord-022594-fx044gcd	199	12	remains	remain	VBZ
cord-022594-fx044gcd	199	13	a	a	DT
cord-022594-fx044gcd	199	14	critical	critical	JJ
cord-022594-fx044gcd	199	15	consideration	consideration	NN
cord-022594-fx044gcd	199	16	in	in	IN
cord-022594-fx044gcd	199	17	the	the	DT
cord-022594-fx044gcd	199	18	diagnosis	diagnosis	NN
cord-022594-fx044gcd	199	19	of	of	IN
cord-022594-fx044gcd	199	20	MS	MS	NNP
cord-022594-fx044gcd	199	21	.	.	.
cord-022594-fx044gcd	200	1	Sensory	sensory	JJ
cord-022594-fx044gcd	200	2	symptoms	symptom	NNS
cord-022594-fx044gcd	200	3	are	be	VBP
cord-022594-fx044gcd	200	4	the	the	DT
cord-022594-fx044gcd	200	5	most	most	RBS
cord-022594-fx044gcd	200	6	common	common	JJ
cord-022594-fx044gcd	200	7	presenting	present	VBG
cord-022594-fx044gcd	200	8	manifestation	manifestation	NN
cord-022594-fx044gcd	200	9	in	in	IN
cord-022594-fx044gcd	200	10	MS	MS	NNP
cord-022594-fx044gcd	200	11	(	(	-LRB-
cord-022594-fx044gcd	200	12	21	21	CD
cord-022594-fx044gcd	200	13	%	%	NN
cord-022594-fx044gcd	200	14	to	to	IN
cord-022594-fx044gcd	200	15	55	55	CD
cord-022594-fx044gcd	200	16	%	%	NN
cord-022594-fx044gcd	200	17	)	)	-RRB-
cord-022594-fx044gcd	200	18	and	and	CC
cord-022594-fx044gcd	200	19	ultimately	ultimately	RB
cord-022594-fx044gcd	200	20	develop	develop	VB
cord-022594-fx044gcd	200	21	in	in	IN
cord-022594-fx044gcd	200	22	nearly	nearly	RB
cord-022594-fx044gcd	200	23	all	all	DT
cord-022594-fx044gcd	200	24	patients	patient	NNS
cord-022594-fx044gcd	200	25	.	.	.
cord-022594-fx044gcd	201	1	29	29	CD
cord-022594-fx044gcd	201	2	Loss	loss	NN
cord-022594-fx044gcd	201	3	of	of	IN
cord-022594-fx044gcd	201	4	sensation	sensation	NN
cord-022594-fx044gcd	201	5	(	(	-LRB-
cord-022594-fx044gcd	201	6	numbness	numbness	NN
cord-022594-fx044gcd	201	7	)	)	-RRB-
cord-022594-fx044gcd	201	8	,	,	,
cord-022594-fx044gcd	201	9	paresthesias	paresthesias	NNP
cord-022594-fx044gcd	201	10	(	(	-LRB-
cord-022594-fx044gcd	201	11	tingling	tingle	VBG
cord-022594-fx044gcd	201	12	)	)	-RRB-
cord-022594-fx044gcd	201	13	,	,	,
cord-022594-fx044gcd	201	14	dysesthesias	dysesthesias	FW
cord-022594-fx044gcd	201	15	(	(	-LRB-
cord-022594-fx044gcd	201	16	burning	burn	VBG
cord-022594-fx044gcd	201	17	)	)	-RRB-
cord-022594-fx044gcd	201	18	,	,	,
cord-022594-fx044gcd	201	19	and	and	CC
cord-022594-fx044gcd	201	20	hyperesthesias	hyperesthesias	NNP
cord-022594-fx044gcd	201	21	are	be	VBP
cord-022594-fx044gcd	201	22	common	common	JJ
cord-022594-fx044gcd	201	23	.	.	.
cord-022594-fx044gcd	202	1	These	these	DT
cord-022594-fx044gcd	202	2	symptoms	symptom	NNS
cord-022594-fx044gcd	202	3	may	may	MD
cord-022594-fx044gcd	202	4	occur	occur	VB
cord-022594-fx044gcd	202	5	in	in	IN
cord-022594-fx044gcd	202	6	practically	practically	RB
cord-022594-fx044gcd	202	7	any	any	DT
cord-022594-fx044gcd	202	8	distribution	distribution	NN
cord-022594-fx044gcd	202	9	:	:	:
cord-022594-fx044gcd	202	10	one	one	CD
cord-022594-fx044gcd	202	11	or	or	CC
cord-022594-fx044gcd	202	12	more	more	JJR
cord-022594-fx044gcd	202	13	limbs	limb	NNS
cord-022594-fx044gcd	202	14	,	,	,
cord-022594-fx044gcd	202	15	part	part	NN
cord-022594-fx044gcd	202	16	of	of	IN
cord-022594-fx044gcd	202	17	a	a	DT
cord-022594-fx044gcd	202	18	limb	limb	NN
cord-022594-fx044gcd	202	19	,	,	,
cord-022594-fx044gcd	202	20	trunk	trunk	NN
cord-022594-fx044gcd	202	21	,	,	,
cord-022594-fx044gcd	202	22	face	face	NN
cord-022594-fx044gcd	202	23	,	,	,
cord-022594-fx044gcd	202	24	or	or	CC
cord-022594-fx044gcd	202	25	combinations	combination	NNS
cord-022594-fx044gcd	202	26	.	.	.
cord-022594-fx044gcd	203	1	The	the	DT
cord-022594-fx044gcd	203	2	more	more	RBR
cord-022594-fx044gcd	203	3	distinctive	distinctive	JJ
cord-022594-fx044gcd	203	4	sensory	sensory	JJ
cord-022594-fx044gcd	203	5	relapses	relapse	NNS
cord-022594-fx044gcd	203	6	of	of	IN
cord-022594-fx044gcd	203	7	MS	MS	NNP
cord-022594-fx044gcd	203	8	consist	consist	VBP
cord-022594-fx044gcd	203	9	of	of	IN
cord-022594-fx044gcd	203	10	the	the	DT
cord-022594-fx044gcd	203	11	sensory	sensory	JJ
cord-022594-fx044gcd	203	12	cord	cord	NN
cord-022594-fx044gcd	203	13	syndrome	syndrome	NN
cord-022594-fx044gcd	203	14	and	and	CC
cord-022594-fx044gcd	203	15	the	the	DT
cord-022594-fx044gcd	203	16	sensory	sensory	JJ
cord-022594-fx044gcd	203	17	useless	useless	JJ
cord-022594-fx044gcd	203	18	hand	hand	NN
cord-022594-fx044gcd	203	19	syndrome	syndrome	NN
cord-022594-fx044gcd	203	20	.	.	.
cord-022594-fx044gcd	204	1	A	a	DT
cord-022594-fx044gcd	204	2	common	common	JJ
cord-022594-fx044gcd	204	3	scenario	scenario	NN
cord-022594-fx044gcd	204	4	is	be	VBZ
cord-022594-fx044gcd	204	5	that	that	DT
cord-022594-fx044gcd	204	6	of	of	IN
cord-022594-fx044gcd	204	7	numbness	numbness	NN
cord-022594-fx044gcd	204	8	or	or	CC
cord-022594-fx044gcd	204	9	tingling	tingling	JJ
cord-022594-fx044gcd	204	10	beginning	begin	VBG
cord-022594-fx044gcd	204	11	in	in	IN
cord-022594-fx044gcd	204	12	one	one	CD
cord-022594-fx044gcd	204	13	foot	foot	NN
cord-022594-fx044gcd	204	14	,	,	,
cord-022594-fx044gcd	204	15	ascending	ascend	VBG
cord-022594-fx044gcd	204	16	first	first	JJ
cord-022594-fx044gcd	204	17	ipsilaterally	ipsilaterally	RB
cord-022594-fx044gcd	204	18	and	and	CC
cord-022594-fx044gcd	204	19	then	then	RB
cord-022594-fx044gcd	204	20	contralaterally	contralaterally	RB
cord-022594-fx044gcd	204	21	.	.	.
cord-022594-fx044gcd	205	1	The	the	DT
cord-022594-fx044gcd	205	2	sensory	sensory	JJ
cord-022594-fx044gcd	205	3	symptoms	symptom	NNS
cord-022594-fx044gcd	205	4	may	may	MD
cord-022594-fx044gcd	205	5	ascend	ascend	VB
cord-022594-fx044gcd	205	6	to	to	IN
cord-022594-fx044gcd	205	7	the	the	DT
cord-022594-fx044gcd	205	8	trunk	trunk	NN
cord-022594-fx044gcd	205	9	,	,	,
cord-022594-fx044gcd	205	10	producing	produce	VBG
cord-022594-fx044gcd	205	11	a	a	DT
cord-022594-fx044gcd	205	12	sensory	sensory	JJ
cord-022594-fx044gcd	205	13	level	level	NN
cord-022594-fx044gcd	205	14	,	,	,
cord-022594-fx044gcd	205	15	or	or	CC
cord-022594-fx044gcd	205	16	may	may	MD
cord-022594-fx044gcd	205	17	involve	involve	VB
cord-022594-fx044gcd	205	18	the	the	DT
cord-022594-fx044gcd	205	19	upper	upper	JJ
cord-022594-fx044gcd	205	20	extremities	extremity	NNS
cord-022594-fx044gcd	205	21	.	.	.
cord-022594-fx044gcd	206	1	Associated	associated	JJ
cord-022594-fx044gcd	206	2	symptoms	symptom	NNS
cord-022594-fx044gcd	206	3	commonly	commonly	RB
cord-022594-fx044gcd	206	4	include	include	VBP
cord-022594-fx044gcd	206	5	poor	poor	JJ
cord-022594-fx044gcd	206	6	balance	balance	NN
cord-022594-fx044gcd	206	7	,	,	,
cord-022594-fx044gcd	206	8	weakness	weakness	NN
cord-022594-fx044gcd	206	9	,	,	,
cord-022594-fx044gcd	206	10	urinary	urinary	JJ
cord-022594-fx044gcd	206	11	urgency	urgency	NN
cord-022594-fx044gcd	206	12	,	,	,
cord-022594-fx044gcd	206	13	constipation	constipation	NN
cord-022594-fx044gcd	206	14	,	,	,
cord-022594-fx044gcd	206	15	and	and	CC
cord-022594-fx044gcd	206	16	Lhermitte	Lhermitte	NNP
cord-022594-fx044gcd	206	17	's	's	POS
cord-022594-fx044gcd	206	18	sign	sign	NN
cord-022594-fx044gcd	206	19	(	(	-LRB-
cord-022594-fx044gcd	206	20	see	see	VB
cord-022594-fx044gcd	206	21	later	later	RB
cord-022594-fx044gcd	206	22	)	)	-RRB-
cord-022594-fx044gcd	206	23	.	.	.
cord-022594-fx044gcd	207	1	Brown	Brown	NNP
cord-022594-fx044gcd	207	2	-	-	HYPH
cord-022594-fx044gcd	207	3	Séquard	Séquard	NNP
cord-022594-fx044gcd	207	4	syndrome	syndrome	NN
cord-022594-fx044gcd	207	5	may	may	MD
cord-022594-fx044gcd	207	6	occur	occur	VB
cord-022594-fx044gcd	207	7	with	with	IN
cord-022594-fx044gcd	207	8	sensory	sensory	JJ
cord-022594-fx044gcd	207	9	disassociation	disassociation	NN
cord-022594-fx044gcd	207	10	and	and	CC
cord-022594-fx044gcd	207	11	hemiparesis	hemiparesis	NN
cord-022594-fx044gcd	207	12	.	.	.
cord-022594-fx044gcd	208	1	The	the	DT
cord-022594-fx044gcd	208	2	sensory	sensory	JJ
cord-022594-fx044gcd	208	3	cord	cord	NN
cord-022594-fx044gcd	208	4	syndrome	syndrome	NN
cord-022594-fx044gcd	208	5	reflects	reflect	VBZ
cord-022594-fx044gcd	208	6	an	an	DT
cord-022594-fx044gcd	208	7	evolving	evolve	VBG
cord-022594-fx044gcd	208	8	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	208	9	lesion	lesion	NN
cord-022594-fx044gcd	208	10	that	that	WDT
cord-022594-fx044gcd	208	11	begins	begin	VBZ
cord-022594-fx044gcd	208	12	in	in	IN
cord-022594-fx044gcd	208	13	the	the	DT
cord-022594-fx044gcd	208	14	medial	medial	JJ
cord-022594-fx044gcd	208	15	posterior	posterior	JJ
cord-022594-fx044gcd	208	16	column	column	NN
cord-022594-fx044gcd	208	17	ipsilateral	ipsilateral	JJ
cord-022594-fx044gcd	208	18	to	to	IN
cord-022594-fx044gcd	208	19	the	the	DT
cord-022594-fx044gcd	208	20	first	first	JJ
cord-022594-fx044gcd	208	21	symptoms	symptom	NNS
cord-022594-fx044gcd	208	22	.	.	.
cord-022594-fx044gcd	209	1	Sensory	sensory	JJ
cord-022594-fx044gcd	209	2	cord	cord	NN
cord-022594-fx044gcd	209	3	syndromes	syndrome	NNS
cord-022594-fx044gcd	209	4	are	be	VBP
cord-022594-fx044gcd	209	5	common	common	JJ
cord-022594-fx044gcd	209	6	in	in	IN
cord-022594-fx044gcd	209	7	MS	MS	NNP
cord-022594-fx044gcd	209	8	and	and	CC
cord-022594-fx044gcd	209	9	suggest	suggest	VBP
cord-022594-fx044gcd	209	10	the	the	DT
cord-022594-fx044gcd	209	11	diagnosis	diagnosis	NN
cord-022594-fx044gcd	209	12	when	when	WRB
cord-022594-fx044gcd	209	13	they	-PRON-	PRP
cord-022594-fx044gcd	209	14	occur	occur	VBP
cord-022594-fx044gcd	209	15	in	in	IN
cord-022594-fx044gcd	209	16	young	young	JJ
cord-022594-fx044gcd	209	17	persons	person	NNS
cord-022594-fx044gcd	209	18	and	and	CC
cord-022594-fx044gcd	209	19	remit	remit	VB
cord-022594-fx044gcd	209	20	spontaneously	spontaneously	RB
cord-022594-fx044gcd	209	21	or	or	CC
cord-022594-fx044gcd	209	22	in	in	IN
cord-022594-fx044gcd	209	23	response	response	NN
cord-022594-fx044gcd	209	24	to	to	IN
cord-022594-fx044gcd	209	25	corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	209	26	.	.	.
cord-022594-fx044gcd	210	1	Patients	patient	NNS
cord-022594-fx044gcd	210	2	with	with	IN
cord-022594-fx044gcd	210	3	the	the	DT
cord-022594-fx044gcd	210	4	sensory	sensory	JJ
cord-022594-fx044gcd	210	5	useless	useless	JJ
cord-022594-fx044gcd	210	6	hand	hand	NN
cord-022594-fx044gcd	210	7	may	may	MD
cord-022594-fx044gcd	210	8	note	note	VB
cord-022594-fx044gcd	210	9	subjective	subjective	JJ
cord-022594-fx044gcd	210	10	numbness	numbness	NN
cord-022594-fx044gcd	210	11	and	and	CC
cord-022594-fx044gcd	210	12	lose	lose	VB
cord-022594-fx044gcd	210	13	discriminatory	discriminatory	JJ
cord-022594-fx044gcd	210	14	and	and	CC
cord-022594-fx044gcd	210	15	proprioceptive	proprioceptive	JJ
cord-022594-fx044gcd	210	16	function	function	NN
cord-022594-fx044gcd	210	17	,	,	,
cord-022594-fx044gcd	210	18	resulting	result	VBG
cord-022594-fx044gcd	210	19	in	in	IN
cord-022594-fx044gcd	210	20	difficulty	difficulty	NN
cord-022594-fx044gcd	210	21	writing	writing	NN
cord-022594-fx044gcd	210	22	,	,	,
cord-022594-fx044gcd	210	23	typing	typing	NN
cord-022594-fx044gcd	210	24	,	,	,
cord-022594-fx044gcd	210	25	buttoning	button	VBG
cord-022594-fx044gcd	210	26	clothes	clothe	NNS
cord-022594-fx044gcd	210	27	,	,	,
cord-022594-fx044gcd	210	28	and	and	CC
cord-022594-fx044gcd	210	29	holding	hold	VBG
cord-022594-fx044gcd	210	30	onto	onto	IN
cord-022594-fx044gcd	210	31	objects	object	NNS
cord-022594-fx044gcd	210	32	,	,	,
cord-022594-fx044gcd	210	33	especially	especially	RB
cord-022594-fx044gcd	210	34	when	when	WRB
cord-022594-fx044gcd	210	35	not	not	RB
cord-022594-fx044gcd	210	36	looking	look	VBG
cord-022594-fx044gcd	210	37	at	at	IN
cord-022594-fx044gcd	210	38	the	the	DT
cord-022594-fx044gcd	210	39	hand	hand	NN
cord-022594-fx044gcd	210	40	.	.	.
cord-022594-fx044gcd	211	1	This	this	DT
cord-022594-fx044gcd	211	2	problem	problem	NN
cord-022594-fx044gcd	211	3	can	can	MD
cord-022594-fx044gcd	211	4	occur	occur	VB
cord-022594-fx044gcd	211	5	bilaterally	bilaterally	RB
cord-022594-fx044gcd	211	6	even	even	RB
cord-022594-fx044gcd	211	7	without	without	IN
cord-022594-fx044gcd	211	8	lower	low	JJR
cord-022594-fx044gcd	211	9	extremity	extremity	NN
cord-022594-fx044gcd	211	10	symptoms	symptom	NNS
cord-022594-fx044gcd	211	11	.	.	.
cord-022594-fx044gcd	212	1	The	the	DT
cord-022594-fx044gcd	212	2	responsible	responsible	JJ
cord-022594-fx044gcd	212	3	lesion	lesion	NN
cord-022594-fx044gcd	212	4	is	be	VBZ
cord-022594-fx044gcd	212	5	in	in	IN
cord-022594-fx044gcd	212	6	the	the	DT
cord-022594-fx044gcd	212	7	lemniscal	lemniscal	JJ
cord-022594-fx044gcd	212	8	pathways	pathway	NNS
cord-022594-fx044gcd	212	9	either	either	CC
cord-022594-fx044gcd	212	10	in	in	IN
cord-022594-fx044gcd	212	11	the	the	DT
cord-022594-fx044gcd	212	12	cervical	cervical	JJ
cord-022594-fx044gcd	212	13	spinal	spinal	JJ
cord-022594-fx044gcd	212	14	cord	cord	NN
cord-022594-fx044gcd	212	15	or	or	CC
cord-022594-fx044gcd	212	16	in	in	IN
cord-022594-fx044gcd	212	17	the	the	DT
cord-022594-fx044gcd	212	18	brain	brain	NN
cord-022594-fx044gcd	212	19	stem	stem	NN
cord-022594-fx044gcd	212	20	.	.	.
cord-022594-fx044gcd	213	1	This	this	DT
cord-022594-fx044gcd	213	2	syndrome	syndrome	NN
cord-022594-fx044gcd	213	3	usually	usually	RB
cord-022594-fx044gcd	213	4	remits	remit	VBZ
cord-022594-fx044gcd	213	5	over	over	IN
cord-022594-fx044gcd	213	6	several	several	JJ
cord-022594-fx044gcd	213	7	months	month	NNS
cord-022594-fx044gcd	213	8	.	.	.
cord-022594-fx044gcd	214	1	The	the	DT
cord-022594-fx044gcd	214	2	useless	useless	JJ
cord-022594-fx044gcd	214	3	hand	hand	NN
cord-022594-fx044gcd	214	4	syndrome	syndrome	NN
cord-022594-fx044gcd	214	5	is	be	VBZ
cord-022594-fx044gcd	214	6	a	a	DT
cord-022594-fx044gcd	214	7	very	very	RB
cord-022594-fx044gcd	214	8	specific	specific	JJ
cord-022594-fx044gcd	214	9	symptom	symptom	NN
cord-022594-fx044gcd	214	10	and	and	CC
cord-022594-fx044gcd	214	11	is	be	VBZ
cord-022594-fx044gcd	214	12	only	only	RB
cord-022594-fx044gcd	214	13	rarely	rarely	RB
cord-022594-fx044gcd	214	14	caused	cause	VBN
cord-022594-fx044gcd	214	15	by	by	IN
cord-022594-fx044gcd	214	16	other	other	JJ
cord-022594-fx044gcd	214	17	disorders	disorder	NNS
cord-022594-fx044gcd	214	18	.	.	.
cord-022594-fx044gcd	215	1	A	a	DT
cord-022594-fx044gcd	215	2	large	large	JJ
cord-022594-fx044gcd	215	3	portion	portion	NN
cord-022594-fx044gcd	215	4	of	of	IN
cord-022594-fx044gcd	215	5	MS	MS	NNP
cord-022594-fx044gcd	215	6	patients	patient	NNS
cord-022594-fx044gcd	215	7	have	have	VBP
cord-022594-fx044gcd	215	8	persistent	persistent	JJ
cord-022594-fx044gcd	215	9	sensory	sensory	JJ
cord-022594-fx044gcd	215	10	loss	loss	NN
cord-022594-fx044gcd	215	11	,	,	,
cord-022594-fx044gcd	215	12	usually	usually	RB
cord-022594-fx044gcd	215	13	consisting	consist	VBG
cord-022594-fx044gcd	215	14	of	of	IN
cord-022594-fx044gcd	215	15	diminished	diminished	JJ
cord-022594-fx044gcd	215	16	vibratory	vibratory	NN
cord-022594-fx044gcd	215	17	and	and	CC
cord-022594-fx044gcd	215	18	position	position	NN
cord-022594-fx044gcd	215	19	sensation	sensation	NN
cord-022594-fx044gcd	215	20	in	in	IN
cord-022594-fx044gcd	215	21	distal	distal	JJ
cord-022594-fx044gcd	215	22	extremities	extremity	NNS
cord-022594-fx044gcd	215	23	(	(	-LRB-
cord-022594-fx044gcd	215	24	Video	Video	NNP
cord-022594-fx044gcd	215	25	5	5	CD
cord-022594-fx044gcd	215	26	,	,	,
cord-022594-fx044gcd	215	27	Sensory	Sensory	NNP
cord-022594-fx044gcd	215	28	Ataxia	Ataxia	NNP
cord-022594-fx044gcd	215	29	)	)	-RRB-
cord-022594-fx044gcd	215	30	.	.	.
cord-022594-fx044gcd	216	1	Itching	itching	NN
cord-022594-fx044gcd	216	2	may	may	MD
cord-022594-fx044gcd	216	3	occur	occur	VB
cord-022594-fx044gcd	216	4	in	in	IN
cord-022594-fx044gcd	216	5	a	a	DT
cord-022594-fx044gcd	216	6	dermatomal	dermatomal	JJ
cord-022594-fx044gcd	216	7	distribution	distribution	NN
cord-022594-fx044gcd	216	8	with	with	IN
cord-022594-fx044gcd	216	9	relapse	relapse	NN
cord-022594-fx044gcd	216	10	or	or	CC
cord-022594-fx044gcd	216	11	in	in	IN
cord-022594-fx044gcd	216	12	paroxysms	paroxysm	NNS
cord-022594-fx044gcd	216	13	.	.	.
cord-022594-fx044gcd	217	1	Pain	pain	NN
cord-022594-fx044gcd	217	2	is	be	VBZ
cord-022594-fx044gcd	217	3	not	not	RB
cord-022594-fx044gcd	217	4	a	a	DT
cord-022594-fx044gcd	217	5	major	major	JJ
cord-022594-fx044gcd	217	6	manifestation	manifestation	NN
cord-022594-fx044gcd	217	7	of	of	IN
cord-022594-fx044gcd	217	8	MS	MS	NNP
cord-022594-fx044gcd	217	9	,	,	,
cord-022594-fx044gcd	217	10	but	but	CC
cord-022594-fx044gcd	217	11	distressing	distressing	JJ
cord-022594-fx044gcd	217	12	lower	low	JJR
cord-022594-fx044gcd	217	13	extremity	extremity	NN
cord-022594-fx044gcd	217	14	dysesthetic	dysesthetic	JJ
cord-022594-fx044gcd	217	15	pain	pain	NN
cord-022594-fx044gcd	217	16	associated	associate	VBN
cord-022594-fx044gcd	217	17	with	with	IN
cord-022594-fx044gcd	217	18	spinal	spinal	JJ
cord-022594-fx044gcd	217	19	cord	cord	NN
cord-022594-fx044gcd	217	20	involvement	involvement	NN
cord-022594-fx044gcd	217	21	,	,	,
cord-022594-fx044gcd	217	22	radicular	radicular	JJ
cord-022594-fx044gcd	217	23	pain	pain	NN
cord-022594-fx044gcd	217	24	from	from	IN
cord-022594-fx044gcd	217	25	lesions	lesion	NNS
cord-022594-fx044gcd	217	26	at	at	IN
cord-022594-fx044gcd	217	27	the	the	DT
cord-022594-fx044gcd	217	28	root	root	NN
cord-022594-fx044gcd	217	29	entry	entry	NN
cord-022594-fx044gcd	217	30	zone	zone	NN
cord-022594-fx044gcd	217	31	,	,	,
cord-022594-fx044gcd	217	32	paroxysms	paroxysm	NNS
cord-022594-fx044gcd	217	33	,	,	,
cord-022594-fx044gcd	217	34	and	and	CC
cord-022594-fx044gcd	217	35	an	an	DT
cord-022594-fx044gcd	217	36	uncomfortable	uncomfortable	JJ
cord-022594-fx044gcd	217	37	sensation	sensation	NN
cord-022594-fx044gcd	217	38	of	of	IN
cord-022594-fx044gcd	217	39	pressure	pressure	NN
cord-022594-fx044gcd	217	40	or	or	CC
cord-022594-fx044gcd	217	41	tightness	tightness	NN
cord-022594-fx044gcd	217	42	surrounding	surround	VBG
cord-022594-fx044gcd	217	43	a	a	DT
cord-022594-fx044gcd	217	44	leg	leg	NN
cord-022594-fx044gcd	217	45	or	or	CC
cord-022594-fx044gcd	217	46	the	the	DT
cord-022594-fx044gcd	217	47	trunk	trunk	NN
cord-022594-fx044gcd	217	48	may	may	MD
cord-022594-fx044gcd	217	49	be	be	VB
cord-022594-fx044gcd	217	50	present	present	JJ
cord-022594-fx044gcd	217	51	.	.	.
cord-022594-fx044gcd	218	1	Pyramidal	pyramidal	JJ
cord-022594-fx044gcd	218	2	tract	tract	NN
cord-022594-fx044gcd	218	3	dysfunction	dysfunction	NN
cord-022594-fx044gcd	218	4	is	be	VBZ
cord-022594-fx044gcd	218	5	common	common	JJ
cord-022594-fx044gcd	218	6	in	in	IN
cord-022594-fx044gcd	218	7	MS	MS	NNP
cord-022594-fx044gcd	218	8	and	and	CC
cord-022594-fx044gcd	218	9	causes	cause	VBZ
cord-022594-fx044gcd	218	10	weakness	weakness	NN
cord-022594-fx044gcd	218	11	,	,	,
cord-022594-fx044gcd	218	12	spasticity	spasticity	NN
cord-022594-fx044gcd	218	13	,	,	,
cord-022594-fx044gcd	218	14	loss	loss	NN
cord-022594-fx044gcd	218	15	of	of	IN
cord-022594-fx044gcd	218	16	dexterity	dexterity	NN
cord-022594-fx044gcd	218	17	,	,	,
cord-022594-fx044gcd	218	18	and	and	CC
cord-022594-fx044gcd	218	19	hyperreflexia	hyperreflexia	NNP
cord-022594-fx044gcd	218	20	(	(	-LRB-
cord-022594-fx044gcd	218	21	Video	Video	NNP
cord-022594-fx044gcd	218	22	80	80	CD
cord-022594-fx044gcd	218	23	,	,	,
cord-022594-fx044gcd	218	24	Hyper	hyper	JJ
cord-022594-fx044gcd	218	25	-	-	NN
cord-022594-fx044gcd	218	26	reflexia	reflexia	NNP
cord-022594-fx044gcd	218	27	)	)	-RRB-
cord-022594-fx044gcd	218	28	.	.	.
cord-022594-fx044gcd	219	1	Motor	motor	NN
cord-022594-fx044gcd	219	2	deficits	deficit	NNS
cord-022594-fx044gcd	219	3	can	can	MD
cord-022594-fx044gcd	219	4	occur	occur	VB
cord-022594-fx044gcd	219	5	acutely	acutely	RB
cord-022594-fx044gcd	219	6	or	or	CC
cord-022594-fx044gcd	219	7	in	in	IN
cord-022594-fx044gcd	219	8	a	a	DT
cord-022594-fx044gcd	219	9	chronic	chronic	JJ
cord-022594-fx044gcd	219	10	progression	progression	NN
cord-022594-fx044gcd	219	11	with	with	IN
cord-022594-fx044gcd	219	12	weakness	weakness	NN
cord-022594-fx044gcd	219	13	of	of	IN
cord-022594-fx044gcd	219	14	one	one	CD
cord-022594-fx044gcd	219	15	or	or	CC
cord-022594-fx044gcd	219	16	more	more	JJR
cord-022594-fx044gcd	219	17	limbs	limb	NNS
cord-022594-fx044gcd	219	18	and	and	CC
cord-022594-fx044gcd	219	19	facial	facial	JJ
cord-022594-fx044gcd	219	20	weakness	weakness	NN
cord-022594-fx044gcd	219	21	,	,	,
cord-022594-fx044gcd	219	22	leg	leg	NN
cord-022594-fx044gcd	219	23	stiffness	stiffness	NN
cord-022594-fx044gcd	219	24	that	that	WDT
cord-022594-fx044gcd	219	25	impairs	impair	VBZ
cord-022594-fx044gcd	219	26	gait	gait	NN
cord-022594-fx044gcd	219	27	and	and	CC
cord-022594-fx044gcd	219	28	balance	balance	NN
cord-022594-fx044gcd	219	29	,	,	,
cord-022594-fx044gcd	219	30	or	or	CC
cord-022594-fx044gcd	219	31	extensor	extensor	NN
cord-022594-fx044gcd	219	32	and	and	CC
cord-022594-fx044gcd	219	33	flexor	flexor	NN
cord-022594-fx044gcd	219	34	spasms	spasm	NNS
cord-022594-fx044gcd	219	35	(	(	-LRB-
cord-022594-fx044gcd	219	36	Video	Video	NNP
cord-022594-fx044gcd	219	37	3	3	CD
cord-022594-fx044gcd	219	38	,	,	,
cord-022594-fx044gcd	219	39	Spastic	Spastic	NNP
cord-022594-fx044gcd	219	40	Gait	Gait	NNP
cord-022594-fx044gcd	219	41	)	)	-RRB-
cord-022594-fx044gcd	219	42	.	.	.
cord-022594-fx044gcd	220	1	Exercise	exercise	NN
cord-022594-fx044gcd	220	2	or	or	CC
cord-022594-fx044gcd	220	3	heat	heat	VB
cord-022594-fx044gcd	220	4	frequently	frequently	RB
cord-022594-fx044gcd	220	5	worsens	worsen	VBZ
cord-022594-fx044gcd	220	6	subtle	subtle	JJ
cord-022594-fx044gcd	220	7	deficits	deficit	NNS
cord-022594-fx044gcd	220	8	.	.	.
cord-022594-fx044gcd	221	1	Muscle	muscle	NN
cord-022594-fx044gcd	221	2	atrophy	atrophy	NN
cord-022594-fx044gcd	221	3	is	be	VBZ
cord-022594-fx044gcd	221	4	usually	usually	RB
cord-022594-fx044gcd	221	5	due	due	JJ
cord-022594-fx044gcd	221	6	to	to	IN
cord-022594-fx044gcd	221	7	disuse	disuse	NN
cord-022594-fx044gcd	221	8	,	,	,
cord-022594-fx044gcd	221	9	but	but	CC
cord-022594-fx044gcd	221	10	lesions	lesion	NNS
cord-022594-fx044gcd	221	11	of	of	IN
cord-022594-fx044gcd	221	12	lower	low	JJR
cord-022594-fx044gcd	221	13	motor	motor	NN
cord-022594-fx044gcd	221	14	neuron	neuron	NN
cord-022594-fx044gcd	221	15	fibers	fiber	NNS
cord-022594-fx044gcd	221	16	or	or	CC
cord-022594-fx044gcd	221	17	of	of	IN
cord-022594-fx044gcd	221	18	the	the	DT
cord-022594-fx044gcd	221	19	anterior	anterior	JJ
cord-022594-fx044gcd	221	20	horn	horn	NN
cord-022594-fx044gcd	221	21	itself	-PRON-	PRP
cord-022594-fx044gcd	221	22	can	can	MD
cord-022594-fx044gcd	221	23	cause	cause	VB
cord-022594-fx044gcd	221	24	a	a	DT
cord-022594-fx044gcd	221	25	pseudoradiculopathy	pseudoradiculopathy	NN
cord-022594-fx044gcd	221	26	with	with	IN
cord-022594-fx044gcd	221	27	segmental	segmental	JJ
cord-022594-fx044gcd	221	28	weakness	weakness	NN
cord-022594-fx044gcd	221	29	,	,	,
cord-022594-fx044gcd	221	30	atrophy	atrophy	NN
cord-022594-fx044gcd	221	31	,	,	,
cord-022594-fx044gcd	221	32	and	and	CC
cord-022594-fx044gcd	221	33	diminished	diminish	VBD
cord-022594-fx044gcd	221	34	reflexes	reflex	NNS
cord-022594-fx044gcd	221	35	.	.	.
cord-022594-fx044gcd	222	1	Motor	motor	NN
cord-022594-fx044gcd	222	2	symptoms	symptom	NNS
cord-022594-fx044gcd	222	3	are	be	VBP
cord-022594-fx044gcd	222	4	presenting	present	VBG
cord-022594-fx044gcd	222	5	manifestations	manifestation	NNS
cord-022594-fx044gcd	222	6	of	of	IN
cord-022594-fx044gcd	222	7	MS	MS	NNP
cord-022594-fx044gcd	222	8	in	in	IN
cord-022594-fx044gcd	222	9	32	32	CD
cord-022594-fx044gcd	222	10	%	%	NN
cord-022594-fx044gcd	222	11	to	to	IN
cord-022594-fx044gcd	222	12	41	41	CD
cord-022594-fx044gcd	222	13	%	%	NN
cord-022594-fx044gcd	222	14	of	of	IN
cord-022594-fx044gcd	222	15	all	all	DT
cord-022594-fx044gcd	222	16	cases	case	NNS
cord-022594-fx044gcd	222	17	;	;	:
cord-022594-fx044gcd	222	18	their	-PRON-	PRP$
cord-022594-fx044gcd	222	19	prevalence	prevalence	NN
cord-022594-fx044gcd	222	20	is	be	VBZ
cord-022594-fx044gcd	222	21	higher	high	JJR
cord-022594-fx044gcd	222	22	than	than	IN
cord-022594-fx044gcd	222	23	60	60	CD
cord-022594-fx044gcd	222	24	%	%	NN
cord-022594-fx044gcd	222	25	in	in	IN
cord-022594-fx044gcd	222	26	long	long	RB
cord-022594-fx044gcd	222	27	-	-	HYPH
cord-022594-fx044gcd	222	28	standing	stand	VBG
cord-022594-fx044gcd	222	29	MS	MS	NNP
cord-022594-fx044gcd	222	30	.	.	.
cord-022594-fx044gcd	223	1	The	the	DT
cord-022594-fx044gcd	223	2	initial	initial	JJ
cord-022594-fx044gcd	223	3	symptom	symptom	NN
cord-022594-fx044gcd	223	4	of	of	IN
cord-022594-fx044gcd	223	5	MS	MS	NNP
cord-022594-fx044gcd	223	6	is	be	VBZ
cord-022594-fx044gcd	223	7	optic	optic	JJ
cord-022594-fx044gcd	223	8	neuritis	neuritis	NN
cord-022594-fx044gcd	223	9	(	(	-LRB-
cord-022594-fx044gcd	223	10	ON	ON	NNP
cord-022594-fx044gcd	223	11	)	)	-RRB-
cord-022594-fx044gcd	224	1	in	in	IN
cord-022594-fx044gcd	224	2	14	14	CD
cord-022594-fx044gcd	224	3	%	%	NN
cord-022594-fx044gcd	224	4	to	to	TO
cord-022594-fx044gcd	224	5	23	23	CD
cord-022594-fx044gcd	224	6	%	%	NN
cord-022594-fx044gcd	224	7	of	of	IN
cord-022594-fx044gcd	224	8	patients	patient	NNS
cord-022594-fx044gcd	224	9	,	,	,
cord-022594-fx044gcd	224	10	and	and	CC
cord-022594-fx044gcd	224	11	more	more	JJR
cord-022594-fx044gcd	224	12	than	than	IN
cord-022594-fx044gcd	224	13	50	50	CD
cord-022594-fx044gcd	224	14	%	%	NN
cord-022594-fx044gcd	224	15	experience	experience	NN
cord-022594-fx044gcd	224	16	a	a	DT
cord-022594-fx044gcd	224	17	clinical	clinical	JJ
cord-022594-fx044gcd	224	18	episode	episode	NN
cord-022594-fx044gcd	224	19	of	of	IN
cord-022594-fx044gcd	224	20	ON	ON	NNP
cord-022594-fx044gcd	224	21	during	during	IN
cord-022594-fx044gcd	224	22	their	-PRON-	PRP$
cord-022594-fx044gcd	224	23	lifetime	lifetime	NN
cord-022594-fx044gcd	224	24	.	.	.
cord-022594-fx044gcd	225	1	The	the	DT
cord-022594-fx044gcd	225	2	most	most	RBS
cord-022594-fx044gcd	225	3	common	common	JJ
cord-022594-fx044gcd	225	4	manifestation	manifestation	NN
cord-022594-fx044gcd	225	5	is	be	VBZ
cord-022594-fx044gcd	225	6	visual	visual	JJ
cord-022594-fx044gcd	225	7	loss	loss	NN
cord-022594-fx044gcd	225	8	in	in	IN
cord-022594-fx044gcd	225	9	one	one	CD
cord-022594-fx044gcd	225	10	eye	eye	NN
cord-022594-fx044gcd	225	11	that	that	WDT
cord-022594-fx044gcd	225	12	evolves	evolve	VBZ
cord-022594-fx044gcd	225	13	over	over	IN
cord-022594-fx044gcd	225	14	a	a	DT
cord-022594-fx044gcd	225	15	few	few	JJ
cord-022594-fx044gcd	225	16	days	day	NNS
cord-022594-fx044gcd	225	17	.	.	.
cord-022594-fx044gcd	226	1	Periocular	Periocular	NNP
cord-022594-fx044gcd	226	2	pain	pain	NN
cord-022594-fx044gcd	226	3	,	,	,
cord-022594-fx044gcd	226	4	especially	especially	RB
cord-022594-fx044gcd	226	5	with	with	IN
cord-022594-fx044gcd	226	6	eye	eye	NN
cord-022594-fx044gcd	226	7	movement	movement	NN
cord-022594-fx044gcd	226	8	,	,	,
cord-022594-fx044gcd	226	9	usually	usually	RB
cord-022594-fx044gcd	226	10	accompanies	accompany	VBZ
cord-022594-fx044gcd	226	11	and	and	CC
cord-022594-fx044gcd	226	12	may	may	MD
cord-022594-fx044gcd	226	13	precede	precede	VB
cord-022594-fx044gcd	226	14	the	the	DT
cord-022594-fx044gcd	226	15	visual	visual	JJ
cord-022594-fx044gcd	226	16	symptoms	symptom	NNS
cord-022594-fx044gcd	226	17	.	.	.
cord-022594-fx044gcd	227	1	Bilateral	bilateral	JJ
cord-022594-fx044gcd	227	2	simultaneous	simultaneous	JJ
cord-022594-fx044gcd	227	3	ON	ON	NNP
cord-022594-fx044gcd	227	4	is	be	VBZ
cord-022594-fx044gcd	227	5	uncommon	uncommon	JJ
cord-022594-fx044gcd	227	6	in	in	IN
cord-022594-fx044gcd	227	7	adults	adult	NNS
cord-022594-fx044gcd	227	8	,	,	,
cord-022594-fx044gcd	227	9	but	but	CC
cord-022594-fx044gcd	227	10	formal	formal	JJ
cord-022594-fx044gcd	227	11	visual	visual	JJ
cord-022594-fx044gcd	227	12	field	field	NN
cord-022594-fx044gcd	227	13	testing	testing	NN
cord-022594-fx044gcd	227	14	reveals	reveal	VBZ
cord-022594-fx044gcd	227	15	unexpected	unexpected	JJ
cord-022594-fx044gcd	227	16	defects	defect	NNS
cord-022594-fx044gcd	227	17	in	in	IN
cord-022594-fx044gcd	227	18	the	the	DT
cord-022594-fx044gcd	227	19	clinically	clinically	RB
cord-022594-fx044gcd	227	20	normal	normal	JJ
cord-022594-fx044gcd	227	21	eye	eye	NN
cord-022594-fx044gcd	227	22	in	in	IN
cord-022594-fx044gcd	227	23	a	a	DT
cord-022594-fx044gcd	227	24	substantial	substantial	JJ
cord-022594-fx044gcd	227	25	number	number	NN
cord-022594-fx044gcd	227	26	of	of	IN
cord-022594-fx044gcd	227	27	patients	patient	NNS
cord-022594-fx044gcd	227	28	.	.	.
cord-022594-fx044gcd	228	1	Children	child	NNS
cord-022594-fx044gcd	228	2	and	and	CC
cord-022594-fx044gcd	228	3	Asian	asian	JJ
cord-022594-fx044gcd	228	4	patients	patient	NNS
cord-022594-fx044gcd	228	5	are	be	VBP
cord-022594-fx044gcd	228	6	more	more	RBR
cord-022594-fx044gcd	228	7	likely	likely	JJ
cord-022594-fx044gcd	228	8	to	to	TO
cord-022594-fx044gcd	228	9	have	have	VB
cord-022594-fx044gcd	228	10	bilateral	bilateral	JJ
cord-022594-fx044gcd	228	11	simultaneous	simultaneous	JJ
cord-022594-fx044gcd	228	12	ON	on	NN
cord-022594-fx044gcd	228	13	;	;	:
cord-022594-fx044gcd	228	14	it	-PRON-	PRP
cord-022594-fx044gcd	228	15	may	may	MD
cord-022594-fx044gcd	228	16	also	also	RB
cord-022594-fx044gcd	228	17	be	be	VB
cord-022594-fx044gcd	228	18	seen	see	VBN
cord-022594-fx044gcd	228	19	in	in	IN
cord-022594-fx044gcd	228	20	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	228	21	optica	optica	NNP
cord-022594-fx044gcd	228	22	(	(	-LRB-
cord-022594-fx044gcd	228	23	NMO	NMO	NNP
cord-022594-fx044gcd	228	24	)	)	-RRB-
cord-022594-fx044gcd	228	25	patients	patient	NNS
cord-022594-fx044gcd	228	26	.	.	.
cord-022594-fx044gcd	229	1	Examination	examination	NN
cord-022594-fx044gcd	229	2	shows	show	VBZ
cord-022594-fx044gcd	229	3	an	an	DT
cord-022594-fx044gcd	229	4	afferent	afferent	JJ
cord-022594-fx044gcd	229	5	pupillary	pupillary	JJ
cord-022594-fx044gcd	229	6	defect	defect	NN
cord-022594-fx044gcd	229	7	,	,	,
cord-022594-fx044gcd	229	8	diminished	diminish	VBD
cord-022594-fx044gcd	229	9	visual	visual	JJ
cord-022594-fx044gcd	229	10	acuity	acuity	NN
cord-022594-fx044gcd	229	11	,	,	,
cord-022594-fx044gcd	229	12	subdued	subdue	VBN
cord-022594-fx044gcd	229	13	color	color	NN
cord-022594-fx044gcd	229	14	perception	perception	NN
cord-022594-fx044gcd	229	15	,	,	,
cord-022594-fx044gcd	229	16	and	and	CC
cord-022594-fx044gcd	229	17	often	often	RB
cord-022594-fx044gcd	229	18	a	a	DT
cord-022594-fx044gcd	229	19	central	central	JJ
cord-022594-fx044gcd	229	20	scotoma	scotoma	NN
cord-022594-fx044gcd	229	21	(	(	-LRB-
cord-022594-fx044gcd	229	22	Video	Video	NNP
cord-022594-fx044gcd	229	23	200	200	CD
cord-022594-fx044gcd	229	24	,	,	,
cord-022594-fx044gcd	229	25	Afferent	Afferent	NNP
cord-022594-fx044gcd	229	26	Pupillary	Pupillary	NNP
cord-022594-fx044gcd	229	27	Defect	Defect	NNP
cord-022594-fx044gcd	229	28	)	)	-RRB-
cord-022594-fx044gcd	229	29	.	.	.
cord-022594-fx044gcd	230	1	Funduscopic	Funduscopic	NNP
cord-022594-fx044gcd	230	2	examination	examination	NN
cord-022594-fx044gcd	230	3	is	be	VBZ
cord-022594-fx044gcd	230	4	usually	usually	RB
cord-022594-fx044gcd	230	5	normal	normal	JJ
cord-022594-fx044gcd	230	6	but	but	CC
cord-022594-fx044gcd	230	7	occasionally	occasionally	RB
cord-022594-fx044gcd	230	8	will	will	MD
cord-022594-fx044gcd	230	9	reveal	reveal	VB
cord-022594-fx044gcd	230	10	papillitis	papillitis	NNP
cord-022594-fx044gcd	230	11	(	(	-LRB-
cord-022594-fx044gcd	230	12	more	more	RBR
cord-022594-fx044gcd	230	13	common	common	JJ
cord-022594-fx044gcd	230	14	in	in	IN
cord-022594-fx044gcd	230	15	children	child	NNS
cord-022594-fx044gcd	230	16	)	)	-RRB-
cord-022594-fx044gcd	230	17	or	or	CC
cord-022594-fx044gcd	230	18	venous	venous	JJ
cord-022594-fx044gcd	230	19	sheathing	sheathing	NN
cord-022594-fx044gcd	230	20	.	.	.
cord-022594-fx044gcd	231	1	Most	Most	JJS
cord-022594-fx044gcd	231	2	patients	patient	NNS
cord-022594-fx044gcd	231	3	begin	begin	VBP
cord-022594-fx044gcd	231	4	to	to	TO
cord-022594-fx044gcd	231	5	recover	recover	VB
cord-022594-fx044gcd	231	6	within	within	IN
cord-022594-fx044gcd	231	7	2	2	CD
cord-022594-fx044gcd	231	8	weeks	week	NNS
cord-022594-fx044gcd	231	9	,	,	,
cord-022594-fx044gcd	231	10	and	and	CC
cord-022594-fx044gcd	231	11	significant	significant	JJ
cord-022594-fx044gcd	231	12	visual	visual	JJ
cord-022594-fx044gcd	231	13	Patients	patient	NNS
cord-022594-fx044gcd	231	14	with	with	IN
cord-022594-fx044gcd	231	15	frequent	frequent	JJ
cord-022594-fx044gcd	231	16	and	and	CC
cord-022594-fx044gcd	231	17	severe	severe	JJ
cord-022594-fx044gcd	231	18	ON	on	JJ
cord-022594-fx044gcd	231	19	events	event	NNS
cord-022594-fx044gcd	231	20	in	in	IN
cord-022594-fx044gcd	231	21	the	the	DT
cord-022594-fx044gcd	231	22	first	first	JJ
cord-022594-fx044gcd	231	23	2	2	CD
cord-022594-fx044gcd	231	24	years	year	NNS
cord-022594-fx044gcd	231	25	were	be	VBD
cord-022594-fx044gcd	231	26	more	more	RBR
cord-022594-fx044gcd	231	27	likely	likely	JJ
cord-022594-fx044gcd	231	28	to	to	TO
cord-022594-fx044gcd	231	29	convert	convert	VB
cord-022594-fx044gcd	231	30	to	to	IN
cord-022594-fx044gcd	231	31	NMO	NMO	NNP
cord-022594-fx044gcd	231	32	;	;	:
cord-022594-fx044gcd	231	33	they	-PRON-	PRP
cord-022594-fx044gcd	231	34	also	also	RB
cord-022594-fx044gcd	231	35	had	have	VBD
cord-022594-fx044gcd	231	36	a	a	DT
cord-022594-fx044gcd	231	37	higher	high	JJR
cord-022594-fx044gcd	231	38	likelihood	likelihood	NN
cord-022594-fx044gcd	231	39	for	for	IN
cord-022594-fx044gcd	231	40	significant	significant	JJ
cord-022594-fx044gcd	231	41	persistent	persistent	JJ
cord-022594-fx044gcd	231	42	vision	vision	NN
cord-022594-fx044gcd	231	43	loss	loss	NN
cord-022594-fx044gcd	231	44	.	.	.
cord-022594-fx044gcd	232	1	30	30	CD
cord-022594-fx044gcd	232	2	Cerebellar	cerebellar	JJ
cord-022594-fx044gcd	232	3	pathways	pathway	NNS
cord-022594-fx044gcd	232	4	are	be	VBP
cord-022594-fx044gcd	232	5	frequently	frequently	RB
cord-022594-fx044gcd	232	6	involved	involve	VBN
cord-022594-fx044gcd	232	7	during	during	IN
cord-022594-fx044gcd	232	8	the	the	DT
cord-022594-fx044gcd	232	9	course	course	NN
cord-022594-fx044gcd	232	10	of	of	IN
cord-022594-fx044gcd	232	11	MS	MS	NNP
cord-022594-fx044gcd	232	12	,	,	,
cord-022594-fx044gcd	232	13	but	but	CC
cord-022594-fx044gcd	232	14	a	a	DT
cord-022594-fx044gcd	232	15	predominately	predominately	RB
cord-022594-fx044gcd	232	16	cerebellar	cerebellar	JJ
cord-022594-fx044gcd	232	17	syndrome	syndrome	NN
cord-022594-fx044gcd	232	18	is	be	VBZ
cord-022594-fx044gcd	232	19	uncommon	uncommon	JJ
cord-022594-fx044gcd	232	20	at	at	IN
cord-022594-fx044gcd	232	21	onset	onset	NN
cord-022594-fx044gcd	232	22	.	.	.
cord-022594-fx044gcd	233	1	The	the	DT
cord-022594-fx044gcd	233	2	manifestations	manifestation	NNS
cord-022594-fx044gcd	233	3	include	include	VBP
cord-022594-fx044gcd	233	4	dysmetria	dysmetria	NNP
cord-022594-fx044gcd	233	5	,	,	,
cord-022594-fx044gcd	233	6	dysdiadochokinesia	dysdiadochokinesia	NNP
cord-022594-fx044gcd	233	7	(	(	-LRB-
cord-022594-fx044gcd	233	8	Video	Video	NNP
cord-022594-fx044gcd	233	9	12	12	CD
cord-022594-fx044gcd	233	10	,	,	,
cord-022594-fx044gcd	233	11	Dysdiadochokinesis	Dysdiadochokinesis	NNP
cord-022594-fx044gcd	233	12	)	)	-RRB-
cord-022594-fx044gcd	233	13	,	,	,
cord-022594-fx044gcd	233	14	action	action	NN
cord-022594-fx044gcd	233	15	tremor	tremor	NN
cord-022594-fx044gcd	233	16	with	with	IN
cord-022594-fx044gcd	233	17	terminal	terminal	JJ
cord-022594-fx044gcd	233	18	accentuation	accentuation	NN
cord-022594-fx044gcd	233	19	,	,	,
cord-022594-fx044gcd	233	20	dysrhythmia	dysrhythmia	NN
cord-022594-fx044gcd	233	21	,	,	,
cord-022594-fx044gcd	233	22	breakdown	breakdown	NN
cord-022594-fx044gcd	233	23	of	of	IN
cord-022594-fx044gcd	233	24	complex	complex	JJ
cord-022594-fx044gcd	233	25	motor	motor	NN
cord-022594-fx044gcd	233	26	movements	movement	NNS
cord-022594-fx044gcd	233	27	,	,	,
cord-022594-fx044gcd	233	28	and	and	CC
cord-022594-fx044gcd	233	29	loss	loss	NN
cord-022594-fx044gcd	233	30	of	of	IN
cord-022594-fx044gcd	233	31	balance	balance	NN
cord-022594-fx044gcd	233	32	(	(	-LRB-
cord-022594-fx044gcd	233	33	Video	Video	NNP
cord-022594-fx044gcd	233	34	14	14	CD
cord-022594-fx044gcd	233	35	,	,	,
cord-022594-fx044gcd	233	36	Tremor	Tremor	NNP
cord-022594-fx044gcd	233	37	with	with	IN
cord-022594-fx044gcd	233	38	Ataxia	Ataxia	NNP
cord-022594-fx044gcd	233	39	)	)	-RRB-
cord-022594-fx044gcd	233	40	.	.	.
cord-022594-fx044gcd	234	1	Patients	patient	NNS
cord-022594-fx044gcd	234	2	with	with	IN
cord-022594-fx044gcd	234	3	long	long	RB
cord-022594-fx044gcd	234	4	-	-	HYPH
cord-022594-fx044gcd	234	5	standing	stand	VBG
cord-022594-fx044gcd	234	6	MS	MS	NNP
cord-022594-fx044gcd	234	7	may	may	MD
cord-022594-fx044gcd	234	8	develop	develop	VB
cord-022594-fx044gcd	234	9	a	a	DT
cord-022594-fx044gcd	234	10	"	"	``
cord-022594-fx044gcd	234	11	jiggling	jiggle	VBG
cord-022594-fx044gcd	234	12	"	"	''
cord-022594-fx044gcd	234	13	gait	gait	NN
cord-022594-fx044gcd	234	14	and	and	CC
cord-022594-fx044gcd	234	15	an	an	DT
cord-022594-fx044gcd	234	16	ataxic	ataxic	JJ
cord-022594-fx044gcd	234	17	dysarthria	dysarthria	NN
cord-022594-fx044gcd	234	18	with	with	IN
cord-022594-fx044gcd	234	19	imprecise	imprecise	JJ
cord-022594-fx044gcd	234	20	articulation	articulation	NN
cord-022594-fx044gcd	234	21	,	,	,
cord-022594-fx044gcd	234	22	scanning	scanning	NN
cord-022594-fx044gcd	234	23	speech	speech	NN
cord-022594-fx044gcd	234	24	,	,	,
cord-022594-fx044gcd	234	25	or	or	CC
cord-022594-fx044gcd	234	26	varying	vary	VBG
cord-022594-fx044gcd	234	27	inflection	inflection	NN
cord-022594-fx044gcd	234	28	,	,	,
cord-022594-fx044gcd	234	29	giving	give	VBG
cord-022594-fx044gcd	234	30	it	-PRON-	PRP
cord-022594-fx044gcd	234	31	an	an	DT
cord-022594-fx044gcd	234	32	explosive	explosive	JJ
cord-022594-fx044gcd	234	33	character	character	NN
cord-022594-fx044gcd	234	34	.	.	.
cord-022594-fx044gcd	235	1	Urinary	urinary	JJ
cord-022594-fx044gcd	235	2	urgency	urgency	NN
cord-022594-fx044gcd	235	3	,	,	,
cord-022594-fx044gcd	235	4	frequency	frequency	NN
cord-022594-fx044gcd	235	5	,	,	,
cord-022594-fx044gcd	235	6	and	and	CC
cord-022594-fx044gcd	235	7	urge	urge	VB
cord-022594-fx044gcd	235	8	incontinence	incontinence	NN
cord-022594-fx044gcd	235	9	(	(	-LRB-
cord-022594-fx044gcd	235	10	due	due	IN
cord-022594-fx044gcd	235	11	to	to	IN
cord-022594-fx044gcd	235	12	detrusor	detrusor	VB
cord-022594-fx044gcd	235	13	hyper	hyper	JJ
cord-022594-fx044gcd	235	14	-	-	JJ
cord-022594-fx044gcd	235	15	reflexia	reflexia	JJ
cord-022594-fx044gcd	235	16	or	or	CC
cord-022594-fx044gcd	235	17	detrusor	detrusor	NN
cord-022594-fx044gcd	235	18	-	-	HYPH
cord-022594-fx044gcd	235	19	sphincter	sphincter	NN
cord-022594-fx044gcd	235	20	dyssynergia	dyssynergia	NN
cord-022594-fx044gcd	235	21	)	)	-RRB-
cord-022594-fx044gcd	235	22	result	result	VBP
cord-022594-fx044gcd	235	23	from	from	IN
cord-022594-fx044gcd	235	24	spinal	spinal	JJ
cord-022594-fx044gcd	235	25	cord	cord	NN
cord-022594-fx044gcd	235	26	lesions	lesion	NNS
cord-022594-fx044gcd	235	27	and	and	CC
cord-022594-fx044gcd	235	28	are	be	VBP
cord-022594-fx044gcd	235	29	frequently	frequently	RB
cord-022594-fx044gcd	235	30	encountered	encounter	VBN
cord-022594-fx044gcd	235	31	in	in	IN
cord-022594-fx044gcd	235	32	MS	MS	NNP
cord-022594-fx044gcd	235	33	patients	patient	NNS
cord-022594-fx044gcd	235	34	.	.	.
cord-022594-fx044gcd	236	1	The	the	DT
cord-022594-fx044gcd	236	2	combined	combined	JJ
cord-022594-fx044gcd	236	3	incidence	incidence	NN
cord-022594-fx044gcd	236	4	of	of	IN
cord-022594-fx044gcd	236	5	bowel	bowel	NN
cord-022594-fx044gcd	236	6	and	and	CC
cord-022594-fx044gcd	236	7	bladder	bladder	NN
cord-022594-fx044gcd	236	8	dysfunction	dysfunction	NN
cord-022594-fx044gcd	236	9	in	in	IN
cord-022594-fx044gcd	236	10	MS	MS	NNP
cord-022594-fx044gcd	236	11	is	be	VBZ
cord-022594-fx044gcd	236	12	thought	think	VBN
cord-022594-fx044gcd	236	13	to	to	TO
cord-022594-fx044gcd	236	14	be	be	VB
cord-022594-fx044gcd	236	15	higher	high	JJR
cord-022594-fx044gcd	236	16	than	than	IN
cord-022594-fx044gcd	236	17	70	70	CD
cord-022594-fx044gcd	236	18	%	%	NN
cord-022594-fx044gcd	236	19	.	.	.
cord-022594-fx044gcd	237	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	237	2	of	of	IN
cord-022594-fx044gcd	237	3	bladder	bladder	NN
cord-022594-fx044gcd	237	4	dysfunction	dysfunction	NN
cord-022594-fx044gcd	237	5	may	may	MD
cord-022594-fx044gcd	237	6	be	be	VB
cord-022594-fx044gcd	237	7	transient	transient	JJ
cord-022594-fx044gcd	237	8	and	and	CC
cord-022594-fx044gcd	237	9	occur	occur	VBP
cord-022594-fx044gcd	237	10	with	with	IN
cord-022594-fx044gcd	237	11	an	an	DT
cord-022594-fx044gcd	237	12	exacerbation	exacerbation	NN
cord-022594-fx044gcd	237	13	but	but	CC
cord-022594-fx044gcd	237	14	are	be	VBP
cord-022594-fx044gcd	237	15	commonly	commonly	RB
cord-022594-fx044gcd	237	16	persistent	persistent	JJ
cord-022594-fx044gcd	237	17	.	.	.
cord-022594-fx044gcd	238	1	Impaired	impaired	JJ
cord-022594-fx044gcd	238	2	vesicular	vesicular	JJ
cord-022594-fx044gcd	238	3	sensation	sensation	NN
cord-022594-fx044gcd	238	4	causes	cause	VBZ
cord-022594-fx044gcd	238	5	a	a	DT
cord-022594-fx044gcd	238	6	high	high	JJ
cord-022594-fx044gcd	238	7	capacity	capacity	NN
cord-022594-fx044gcd	238	8	bladder	bladder	NN
cord-022594-fx044gcd	238	9	and	and	CC
cord-022594-fx044gcd	238	10	may	may	MD
cord-022594-fx044gcd	238	11	lead	lead	VB
cord-022594-fx044gcd	238	12	to	to	IN
cord-022594-fx044gcd	238	13	bladder	bladder	NN
cord-022594-fx044gcd	238	14	atonia	atonia	NN
cord-022594-fx044gcd	238	15	with	with	IN
cord-022594-fx044gcd	238	16	thinning	thinning	NN
cord-022594-fx044gcd	238	17	and	and	CC
cord-022594-fx044gcd	238	18	disruption	disruption	NN
cord-022594-fx044gcd	238	19	of	of	IN
cord-022594-fx044gcd	238	20	the	the	DT
cord-022594-fx044gcd	238	21	detrusor	detrusor	NN
cord-022594-fx044gcd	238	22	muscle	muscle	NN
cord-022594-fx044gcd	238	23	.	.	.
cord-022594-fx044gcd	239	1	Incontinence	incontinence	NN
cord-022594-fx044gcd	239	2	results	result	NNS
cord-022594-fx044gcd	239	3	in	in	IN
cord-022594-fx044gcd	239	4	constant	constant	JJ
cord-022594-fx044gcd	239	5	dribbling	dribbling	NN
cord-022594-fx044gcd	239	6	of	of	IN
cord-022594-fx044gcd	239	7	urine	urine	NN
cord-022594-fx044gcd	239	8	in	in	IN
cord-022594-fx044gcd	239	9	this	this	DT
cord-022594-fx044gcd	239	10	irreversible	irreversible	JJ
cord-022594-fx044gcd	239	11	condition	condition	NN
cord-022594-fx044gcd	239	12	.	.	.
cord-022594-fx044gcd	240	1	Interruption	interruption	NN
cord-022594-fx044gcd	240	2	of	of	IN
cord-022594-fx044gcd	240	3	brain	brain	NN
cord-022594-fx044gcd	240	4	stem	stem	NN
cord-022594-fx044gcd	240	5	micturition	micturition	NNP
cord-022594-fx044gcd	240	6	center	center	NN
cord-022594-fx044gcd	240	7	input	input	NN
cord-022594-fx044gcd	240	8	sometimes	sometimes	RB
cord-022594-fx044gcd	240	9	leads	lead	VBZ
cord-022594-fx044gcd	240	10	to	to	IN
cord-022594-fx044gcd	240	11	cocontracture	cocontracture	NN
cord-022594-fx044gcd	240	12	of	of	IN
cord-022594-fx044gcd	240	13	the	the	DT
cord-022594-fx044gcd	240	14	urinary	urinary	JJ
cord-022594-fx044gcd	240	15	sphincter	sphincter	NN
cord-022594-fx044gcd	240	16	and	and	CC
cord-022594-fx044gcd	240	17	detrusor	detrusor	NN
cord-022594-fx044gcd	240	18	muscles	muscle	NNS
cord-022594-fx044gcd	240	19	(	(	-LRB-
cord-022594-fx044gcd	240	20	detrusor	detrusor	NN
cord-022594-fx044gcd	240	21	-	-	HYPH
cord-022594-fx044gcd	240	22	sphincter	sphincter	NN
cord-022594-fx044gcd	240	23	dyssynergia	dyssynergia	NNP
cord-022594-fx044gcd	240	24	)	)	-RRB-
cord-022594-fx044gcd	240	25	.	.	.
cord-022594-fx044gcd	241	1	The	the	DT
cord-022594-fx044gcd	241	2	resulting	result	VBG
cord-022594-fx044gcd	241	3	high	high	JJ
cord-022594-fx044gcd	241	4	pressure	pressure	NN
cord-022594-fx044gcd	241	5	may	may	MD
cord-022594-fx044gcd	241	6	lead	lead	VB
cord-022594-fx044gcd	241	7	to	to	IN
cord-022594-fx044gcd	241	8	hydronephrosis	hydronephrosis	NN
cord-022594-fx044gcd	241	9	and	and	CC
cord-022594-fx044gcd	241	10	chronic	chronic	JJ
cord-022594-fx044gcd	241	11	renal	renal	JJ
cord-022594-fx044gcd	241	12	failure	failure	NN
cord-022594-fx044gcd	241	13	if	if	IN
cord-022594-fx044gcd	241	14	untreated	untreated	JJ
cord-022594-fx044gcd	241	15	.	.	.
cord-022594-fx044gcd	242	1	Constipation	constipation	NN
cord-022594-fx044gcd	242	2	is	be	VBZ
cord-022594-fx044gcd	242	3	a	a	DT
cord-022594-fx044gcd	242	4	common	common	JJ
cord-022594-fx044gcd	242	5	problem	problem	NN
cord-022594-fx044gcd	242	6	,	,	,
cord-022594-fx044gcd	242	7	occurring	occur	VBG
cord-022594-fx044gcd	242	8	in	in	IN
cord-022594-fx044gcd	242	9	39	39	CD
cord-022594-fx044gcd	242	10	%	%	NN
cord-022594-fx044gcd	242	11	to	to	IN
cord-022594-fx044gcd	242	12	53	53	CD
cord-022594-fx044gcd	242	13	%	%	NN
cord-022594-fx044gcd	242	14	of	of	IN
cord-022594-fx044gcd	242	15	MS	MS	NNP
cord-022594-fx044gcd	242	16	patients	patient	NNS
cord-022594-fx044gcd	242	17	,	,	,
cord-022594-fx044gcd	242	18	especially	especially	RB
cord-022594-fx044gcd	242	19	with	with	IN
cord-022594-fx044gcd	242	20	limited	limited	JJ
cord-022594-fx044gcd	242	21	activity	activity	NN
cord-022594-fx044gcd	242	22	and	and	CC
cord-022594-fx044gcd	242	23	spinal	spinal	JJ
cord-022594-fx044gcd	242	24	cord	cord	NN
cord-022594-fx044gcd	242	25	involvement	involvement	NN
cord-022594-fx044gcd	242	26	.	.	.
cord-022594-fx044gcd	243	1	Fecal	fecal	JJ
cord-022594-fx044gcd	243	2	incontinence	incontinence	NN
cord-022594-fx044gcd	243	3	is	be	VBZ
cord-022594-fx044gcd	243	4	a	a	DT
cord-022594-fx044gcd	243	5	socially	socially	RB
cord-022594-fx044gcd	243	6	devastating	devastating	JJ
cord-022594-fx044gcd	243	7	symptom	symptom	NN
cord-022594-fx044gcd	243	8	that	that	WDT
cord-022594-fx044gcd	243	9	is	be	VBZ
cord-022594-fx044gcd	243	10	often	often	RB
cord-022594-fx044gcd	243	11	associated	associate	VBN
cord-022594-fx044gcd	243	12	with	with	IN
cord-022594-fx044gcd	243	13	perineal	perineal	JJ
cord-022594-fx044gcd	243	14	sensory	sensory	JJ
cord-022594-fx044gcd	243	15	loss	loss	NN
cord-022594-fx044gcd	243	16	in	in	IN
cord-022594-fx044gcd	243	17	MS	MS	NNP
cord-022594-fx044gcd	243	18	patients	patient	NNS
cord-022594-fx044gcd	243	19	.	.	.
cord-022594-fx044gcd	244	1	Sexual	sexual	JJ
cord-022594-fx044gcd	244	2	dysfunction	dysfunction	NN
cord-022594-fx044gcd	244	3	is	be	VBZ
cord-022594-fx044gcd	244	4	seldom	seldom	RB
cord-022594-fx044gcd	244	5	mentioned	mention	VBN
cord-022594-fx044gcd	244	6	,	,	,
cord-022594-fx044gcd	244	7	even	even	RB
cord-022594-fx044gcd	244	8	though	though	IN
cord-022594-fx044gcd	244	9	it	-PRON-	PRP
cord-022594-fx044gcd	244	10	is	be	VBZ
cord-022594-fx044gcd	244	11	a	a	DT
cord-022594-fx044gcd	244	12	frequent	frequent	JJ
cord-022594-fx044gcd	244	13	problem	problem	NN
cord-022594-fx044gcd	244	14	in	in	IN
cord-022594-fx044gcd	244	15	MS	MS	NNP
cord-022594-fx044gcd	244	16	.	.	.
cord-022594-fx044gcd	245	1	Nearly	nearly	RB
cord-022594-fx044gcd	245	2	two	two	CD
cord-022594-fx044gcd	245	3	thirds	third	NNS
cord-022594-fx044gcd	245	4	of	of	IN
cord-022594-fx044gcd	245	5	patients	patient	NNS
cord-022594-fx044gcd	245	6	report	report	VBP
cord-022594-fx044gcd	245	7	diminished	diminish	VBD
cord-022594-fx044gcd	245	8	libido	libido	NN
cord-022594-fx044gcd	245	9	.	.	.
cord-022594-fx044gcd	246	1	One	one	CD
cord-022594-fx044gcd	246	2	third	third	NN
cord-022594-fx044gcd	246	3	of	of	IN
cord-022594-fx044gcd	246	4	men	man	NNS
cord-022594-fx044gcd	246	5	have	have	VBP
cord-022594-fx044gcd	246	6	some	some	DT
cord-022594-fx044gcd	246	7	degree	degree	NN
cord-022594-fx044gcd	246	8	of	of	IN
cord-022594-fx044gcd	246	9	erectile	erectile	NN
cord-022594-fx044gcd	246	10	dysfunction	dysfunction	NN
cord-022594-fx044gcd	246	11	,	,	,
cord-022594-fx044gcd	246	12	and	and	CC
cord-022594-fx044gcd	246	13	a	a	DT
cord-022594-fx044gcd	246	14	similar	similar	JJ
cord-022594-fx044gcd	246	15	percentage	percentage	NN
cord-022594-fx044gcd	246	16	of	of	IN
cord-022594-fx044gcd	246	17	women	woman	NNS
cord-022594-fx044gcd	246	18	have	have	VBP
cord-022594-fx044gcd	246	19	deficient	deficient	JJ
cord-022594-fx044gcd	246	20	vaginal	vaginal	JJ
cord-022594-fx044gcd	246	21	lubrication	lubrication	NN
cord-022594-fx044gcd	246	22	.	.	.
cord-022594-fx044gcd	247	1	Besides	besides	IN
cord-022594-fx044gcd	247	2	direct	direct	JJ
cord-022594-fx044gcd	247	3	neurological	neurological	JJ
cord-022594-fx044gcd	247	4	impairment	impairment	NN
cord-022594-fx044gcd	247	5	,	,	,
cord-022594-fx044gcd	247	6	sensory	sensory	JJ
cord-022594-fx044gcd	247	7	loss	loss	NN
cord-022594-fx044gcd	247	8	,	,	,
cord-022594-fx044gcd	247	9	physical	physical	JJ
cord-022594-fx044gcd	247	10	limitations	limitation	NNS
cord-022594-fx044gcd	247	11	,	,	,
cord-022594-fx044gcd	247	12	depression	depression	NN
cord-022594-fx044gcd	247	13	,	,	,
cord-022594-fx044gcd	247	14	and	and	CC
cord-022594-fx044gcd	247	15	fatigue	fatigue	NN
cord-022594-fx044gcd	247	16	additionally	additionally	RB
cord-022594-fx044gcd	247	17	contribute	contribute	VBP
cord-022594-fx044gcd	247	18	to	to	IN
cord-022594-fx044gcd	247	19	sexual	sexual	JJ
cord-022594-fx044gcd	247	20	difficulties	difficulty	NNS
cord-022594-fx044gcd	247	21	in	in	IN
cord-022594-fx044gcd	247	22	MS	MS	NNP
cord-022594-fx044gcd	247	23	patients	patient	NNS
cord-022594-fx044gcd	247	24	.	.	.
cord-022594-fx044gcd	248	1	In	in	IN
cord-022594-fx044gcd	248	2	addition	addition	NN
cord-022594-fx044gcd	248	3	,	,	,
cord-022594-fx044gcd	248	4	the	the	DT
cord-022594-fx044gcd	248	5	partner	partner	NN
cord-022594-fx044gcd	248	6	's	's	POS
cord-022594-fx044gcd	248	7	attitude	attitude	NN
cord-022594-fx044gcd	248	8	and	and	CC
cord-022594-fx044gcd	248	9	psychological	psychological	JJ
cord-022594-fx044gcd	248	10	factors	factor	NNS
cord-022594-fx044gcd	248	11	dealing	deal	VBG
cord-022594-fx044gcd	248	12	with	with	IN
cord-022594-fx044gcd	248	13	self	self	NN
cord-022594-fx044gcd	248	14	-	-	HYPH
cord-022594-fx044gcd	248	15	image	image	NN
cord-022594-fx044gcd	248	16	,	,	,
cord-022594-fx044gcd	248	17	self	self	NN
cord-022594-fx044gcd	248	18	-	-	HYPH
cord-022594-fx044gcd	248	19	esteem	esteem	NN
cord-022594-fx044gcd	248	20	,	,	,
cord-022594-fx044gcd	248	21	and	and	CC
cord-022594-fx044gcd	248	22	fear	fear	NN
cord-022594-fx044gcd	248	23	of	of	IN
cord-022594-fx044gcd	248	24	rejection	rejection	NN
cord-022594-fx044gcd	248	25	may	may	MD
cord-022594-fx044gcd	248	26	also	also	RB
cord-022594-fx044gcd	248	27	lead	lead	VB
cord-022594-fx044gcd	248	28	to	to	IN
cord-022594-fx044gcd	248	29	impotence	impotence	NN
cord-022594-fx044gcd	248	30	or	or	CC
cord-022594-fx044gcd	248	31	loss	loss	NN
cord-022594-fx044gcd	248	32	of	of	IN
cord-022594-fx044gcd	248	33	libido	libido	NN
cord-022594-fx044gcd	248	34	.	.	.
cord-022594-fx044gcd	249	1	Intense	intense	JJ
cord-022594-fx044gcd	249	2	vertigo	vertigo	NN
cord-022594-fx044gcd	249	3	associated	associate	VBN
cord-022594-fx044gcd	249	4	with	with	IN
cord-022594-fx044gcd	249	5	nausea	nausea	NN
cord-022594-fx044gcd	249	6	and	and	CC
cord-022594-fx044gcd	249	7	emesis	emesis	NN
cord-022594-fx044gcd	249	8	is	be	VBZ
cord-022594-fx044gcd	249	9	an	an	DT
cord-022594-fx044gcd	249	10	occasional	occasional	JJ
cord-022594-fx044gcd	249	11	manifestation	manifestation	NN
cord-022594-fx044gcd	249	12	of	of	IN
cord-022594-fx044gcd	249	13	MS	MS	NNP
cord-022594-fx044gcd	249	14	relapse	relapse	NN
cord-022594-fx044gcd	249	15	.	.	.
cord-022594-fx044gcd	250	1	In	in	IN
cord-022594-fx044gcd	250	2	the	the	DT
cord-022594-fx044gcd	250	3	absence	absence	NN
cord-022594-fx044gcd	250	4	of	of	IN
cord-022594-fx044gcd	250	5	a	a	DT
cord-022594-fx044gcd	250	6	clear	clear	JJ
cord-022594-fx044gcd	250	7	diagnosis	diagnosis	NN
cord-022594-fx044gcd	250	8	of	of	IN
cord-022594-fx044gcd	250	9	MS	MS	NNP
cord-022594-fx044gcd	250	10	,	,	,
cord-022594-fx044gcd	250	11	these	these	DT
cord-022594-fx044gcd	250	12	symptoms	symptom	NNS
cord-022594-fx044gcd	250	13	are	be	VBP
cord-022594-fx044gcd	250	14	often	often	RB
cord-022594-fx044gcd	250	15	attributed	attribute	VBN
cord-022594-fx044gcd	250	16	to	to	IN
cord-022594-fx044gcd	250	17	vestibular	vestibular	JJ
cord-022594-fx044gcd	250	18	neuronitis	neuronitis	NN
cord-022594-fx044gcd	250	19	.	.	.
cord-022594-fx044gcd	251	1	Patients	patient	NNS
cord-022594-fx044gcd	251	2	may	may	MD
cord-022594-fx044gcd	251	3	also	also	RB
cord-022594-fx044gcd	251	4	develop	develop	VB
cord-022594-fx044gcd	251	5	a	a	DT
cord-022594-fx044gcd	251	6	persistent	persistent	JJ
cord-022594-fx044gcd	251	7	but	but	CC
cord-022594-fx044gcd	251	8	mild	mild	JJ
cord-022594-fx044gcd	251	9	vertigo	vertigo	NN
cord-022594-fx044gcd	251	10	that	that	WDT
cord-022594-fx044gcd	251	11	is	be	VBZ
cord-022594-fx044gcd	251	12	precipitated	precipitate	VBN
cord-022594-fx044gcd	251	13	by	by	IN
cord-022594-fx044gcd	251	14	movement	movement	NN
cord-022594-fx044gcd	251	15	,	,	,
cord-022594-fx044gcd	251	16	or	or	CC
cord-022594-fx044gcd	251	17	this	this	DT
cord-022594-fx044gcd	251	18	may	may	MD
cord-022594-fx044gcd	251	19	be	be	VB
cord-022594-fx044gcd	251	20	a	a	DT
cord-022594-fx044gcd	251	21	residual	residual	JJ
cord-022594-fx044gcd	251	22	finding	finding	NN
cord-022594-fx044gcd	251	23	after	after	IN
cord-022594-fx044gcd	251	24	an	an	DT
cord-022594-fx044gcd	251	25	acute	acute	JJ
cord-022594-fx044gcd	251	26	relapse	relapse	NN
cord-022594-fx044gcd	251	27	.	.	.
cord-022594-fx044gcd	252	1	Internuclear	Internuclear	NNP
cord-022594-fx044gcd	252	2	ophthalmoplegia	ophthalmoplegia	NNP
cord-022594-fx044gcd	252	3	,	,	,
cord-022594-fx044gcd	252	4	caused	cause	VBN
cord-022594-fx044gcd	252	5	by	by	IN
cord-022594-fx044gcd	252	6	a	a	DT
cord-022594-fx044gcd	252	7	lesion	lesion	NN
cord-022594-fx044gcd	252	8	in	in	IN
cord-022594-fx044gcd	252	9	the	the	DT
cord-022594-fx044gcd	252	10	medial	medial	JJ
cord-022594-fx044gcd	252	11	longitudinal	longitudinal	JJ
cord-022594-fx044gcd	252	12	fasciculus	fasciculus	NN
cord-022594-fx044gcd	252	13	,	,	,
cord-022594-fx044gcd	252	14	is	be	VBZ
cord-022594-fx044gcd	252	15	the	the	DT
cord-022594-fx044gcd	252	16	most	most	RBS
cord-022594-fx044gcd	252	17	common	common	JJ
cord-022594-fx044gcd	252	18	cause	cause	NN
cord-022594-fx044gcd	252	19	of	of	IN
cord-022594-fx044gcd	252	20	diplopia	diplopia	NN
cord-022594-fx044gcd	252	21	in	in	IN
cord-022594-fx044gcd	252	22	MS	MS	NNP
cord-022594-fx044gcd	252	23	patients	patient	NNS
cord-022594-fx044gcd	252	24	(	(	-LRB-
cord-022594-fx044gcd	252	25	Video	Video	NNP
cord-022594-fx044gcd	252	26	200	200	CD
cord-022594-fx044gcd	252	27	,	,	,
cord-022594-fx044gcd	252	28	Afferent	Afferent	NNP
cord-022594-fx044gcd	252	29	Pupillary	Pupillary	NNP
cord-022594-fx044gcd	252	30	Defect	Defect	NNP
cord-022594-fx044gcd	252	31	)	)	-RRB-
cord-022594-fx044gcd	252	32	.	.	.
cord-022594-fx044gcd	253	1	When	when	WRB
cord-022594-fx044gcd	253	2	symptomatic	symptomatic	JJ
cord-022594-fx044gcd	253	3	,	,	,
cord-022594-fx044gcd	253	4	it	-PRON-	PRP
cord-022594-fx044gcd	253	5	produces	produce	VBZ
cord-022594-fx044gcd	253	6	horizontal	horizontal	JJ
cord-022594-fx044gcd	253	7	diplopia	diplopia	NN
cord-022594-fx044gcd	253	8	on	on	IN
cord-022594-fx044gcd	253	9	lateral	lateral	JJ
cord-022594-fx044gcd	253	10	gaze	gaze	NN
cord-022594-fx044gcd	253	11	that	that	WDT
cord-022594-fx044gcd	253	12	usually	usually	RB
cord-022594-fx044gcd	253	13	remits	remit	VBZ
cord-022594-fx044gcd	253	14	.	.	.
cord-022594-fx044gcd	254	1	Examination	examination	NN
cord-022594-fx044gcd	254	2	discloses	disclose	VBZ
cord-022594-fx044gcd	254	3	incomplete	incomplete	JJ
cord-022594-fx044gcd	254	4	or	or	CC
cord-022594-fx044gcd	254	5	slow	slow	JJ
cord-022594-fx044gcd	254	6	adduction	adduction	NN
cord-022594-fx044gcd	254	7	of	of	IN
cord-022594-fx044gcd	254	8	the	the	DT
cord-022594-fx044gcd	254	9	eye	eye	NN
cord-022594-fx044gcd	254	10	ipsilateral	ipsilateral	JJ
cord-022594-fx044gcd	254	11	to	to	IN
cord-022594-fx044gcd	254	12	the	the	DT
cord-022594-fx044gcd	254	13	lesion	lesion	NN
cord-022594-fx044gcd	254	14	and	and	CC
cord-022594-fx044gcd	254	15	nystagmus	nystagmus	NN
cord-022594-fx044gcd	254	16	of	of	IN
cord-022594-fx044gcd	254	17	the	the	DT
cord-022594-fx044gcd	254	18	contralateral	contralateral	JJ
cord-022594-fx044gcd	254	19	eye	eye	NN
cord-022594-fx044gcd	254	20	during	during	IN
cord-022594-fx044gcd	254	21	abduction	abduction	NN
cord-022594-fx044gcd	254	22	(	(	-LRB-
cord-022594-fx044gcd	254	23	see	see	VB
cord-022594-fx044gcd	254	24	Chapter	chapter	NN
cord-022594-fx044gcd	254	25	9	9	CD
cord-022594-fx044gcd	254	26	)	)	-RRB-
cord-022594-fx044gcd	254	27	.	.	.
cord-022594-fx044gcd	255	1	Dissociated	dissociated	JJ
cord-022594-fx044gcd	255	2	nystagmus	nystagmus	NN
cord-022594-fx044gcd	255	3	may	may	MD
cord-022594-fx044gcd	255	4	be	be	VB
cord-022594-fx044gcd	255	5	the	the	DT
cord-022594-fx044gcd	255	6	only	only	JJ
cord-022594-fx044gcd	255	7	finding	finding	NN
cord-022594-fx044gcd	255	8	of	of	IN
cord-022594-fx044gcd	255	9	an	an	DT
cord-022594-fx044gcd	255	10	old	old	JJ
cord-022594-fx044gcd	255	11	or	or	CC
cord-022594-fx044gcd	255	12	subtle	subtle	JJ
cord-022594-fx044gcd	255	13	internuclear	internuclear	JJ
cord-022594-fx044gcd	255	14	ophthalmoplegia	ophthalmoplegia	NNP
cord-022594-fx044gcd	255	15	(	(	-LRB-
cord-022594-fx044gcd	255	16	Video	Video	NNP
cord-022594-fx044gcd	255	17	19	19	CD
cord-022594-fx044gcd	255	18	,	,	,
cord-022594-fx044gcd	255	19	Internuclear	Internuclear	NNP
cord-022594-fx044gcd	255	20	Ophthalmoplegia	Ophthalmoplegia	NNP
cord-022594-fx044gcd	255	21	)	)	-RRB-
cord-022594-fx044gcd	255	22	.	.	.
cord-022594-fx044gcd	256	1	Bilateral	bilateral	JJ
cord-022594-fx044gcd	256	2	internuclear	internuclear	NN
cord-022594-fx044gcd	256	3	ophthalmoplegia	ophthalmoplegia	NNP
cord-022594-fx044gcd	256	4	is	be	VBZ
cord-022594-fx044gcd	256	5	strongly	strongly	RB
cord-022594-fx044gcd	256	6	suggestive	suggestive	JJ
cord-022594-fx044gcd	256	7	of	of	IN
cord-022594-fx044gcd	256	8	MS	MS	NNP
cord-022594-fx044gcd	256	9	,	,	,
cord-022594-fx044gcd	256	10	although	although	IN
cord-022594-fx044gcd	256	11	this	this	DT
cord-022594-fx044gcd	256	12	rarely	rarely	RB
cord-022594-fx044gcd	256	13	may	may	MD
cord-022594-fx044gcd	256	14	occur	occur	VB
cord-022594-fx044gcd	256	15	with	with	IN
cord-022594-fx044gcd	256	16	tumor	tumor	NN
cord-022594-fx044gcd	256	17	,	,	,
cord-022594-fx044gcd	256	18	infarct	infarct	NN
cord-022594-fx044gcd	256	19	,	,	,
cord-022594-fx044gcd	256	20	mitochondrial	mitochondrial	NN
cord-022594-fx044gcd	256	21	cytopathy	cytopathy	NNP
cord-022594-fx044gcd	256	22	,	,	,
cord-022594-fx044gcd	256	23	Wernicke	Wernicke	NNP
cord-022594-fx044gcd	256	24	's	's	POS
cord-022594-fx044gcd	256	25	encephalitis	encephalitis	NN
cord-022594-fx044gcd	256	26	,	,	,
cord-022594-fx044gcd	256	27	and	and	CC
cord-022594-fx044gcd	256	28	Chiari	Chiari	NNP
cord-022594-fx044gcd	256	29	malformation	malformation	NN
cord-022594-fx044gcd	256	30	(	(	-LRB-
cord-022594-fx044gcd	256	31	Video	Video	NNP
cord-022594-fx044gcd	256	32	229	229	CD
cord-022594-fx044gcd	256	33	,	,	,
cord-022594-fx044gcd	256	34	Wernicke	Wernicke	NNP
cord-022594-fx044gcd	256	35	's	's	POS
cord-022594-fx044gcd	256	36	Encephalopathy	Encephalopathy	NNP
cord-022594-fx044gcd	256	37	)	)	-RRB-
cord-022594-fx044gcd	256	38	.	.	.
cord-022594-fx044gcd	257	1	Vertical	vertical	JJ
cord-022594-fx044gcd	257	2	and	and	CC
cord-022594-fx044gcd	257	3	diagonal	diagonal	JJ
cord-022594-fx044gcd	257	4	diplopia	diplopia	NN
cord-022594-fx044gcd	257	5	usually	usually	RB
cord-022594-fx044gcd	257	6	results	result	VBZ
cord-022594-fx044gcd	257	7	from	from	IN
cord-022594-fx044gcd	257	8	skew	skew	NN
cord-022594-fx044gcd	257	9	deviation	deviation	NN
cord-022594-fx044gcd	257	10	.	.	.
cord-022594-fx044gcd	258	1	Nystagmus	Nystagmus	NNP
cord-022594-fx044gcd	258	2	,	,	,
cord-022594-fx044gcd	258	3	slow	slow	JJ
cord-022594-fx044gcd	258	4	saccadic	saccadic	JJ
cord-022594-fx044gcd	258	5	movements	movement	NNS
cord-022594-fx044gcd	258	6	,	,	,
cord-022594-fx044gcd	258	7	broken	break	VBN
cord-022594-fx044gcd	258	8	ocular	ocular	JJ
cord-022594-fx044gcd	258	9	pursuits	pursuit	NNS
cord-022594-fx044gcd	258	10	,	,	,
cord-022594-fx044gcd	258	11	and	and	CC
cord-022594-fx044gcd	258	12	ocular	ocular	JJ
cord-022594-fx044gcd	258	13	dysmetria	dysmetria	NNS
cord-022594-fx044gcd	258	14	are	be	VBP
cord-022594-fx044gcd	258	15	other	other	JJ
cord-022594-fx044gcd	258	16	eye	eye	NN
cord-022594-fx044gcd	258	17	findings	finding	NNS
cord-022594-fx044gcd	258	18	produced	produce	VBN
cord-022594-fx044gcd	258	19	by	by	IN
cord-022594-fx044gcd	258	20	lesions	lesion	NNS
cord-022594-fx044gcd	258	21	of	of	IN
cord-022594-fx044gcd	258	22	cerebellar	cerebellar	JJ
cord-022594-fx044gcd	258	23	and	and	CC
cord-022594-fx044gcd	258	24	vestibular	vestibular	JJ
cord-022594-fx044gcd	258	25	pathways	pathway	NNS
cord-022594-fx044gcd	258	26	(	(	-LRB-
cord-022594-fx044gcd	258	27	see	see	VBP
cord-022594-fx044gcd	258	28	Chapters	chapter	NNS
cord-022594-fx044gcd	258	29	9	9	CD
cord-022594-fx044gcd	258	30	and	and	CC
cord-022594-fx044gcd	258	31	12	12	CD
cord-022594-fx044gcd	258	32	;	;	:
cord-022594-fx044gcd	258	33	Video	Video	NNP
cord-022594-fx044gcd	258	34	228	228	CD
cord-022594-fx044gcd	258	35	,	,	,
cord-022594-fx044gcd	258	36	Saccadic	Saccadic	NNP
cord-022594-fx044gcd	258	37	Dysmetria	Dysmetria	NNP
cord-022594-fx044gcd	258	38	)	)	-RRB-
cord-022594-fx044gcd	258	39	.	.	.
cord-022594-fx044gcd	259	1	Abducens	Abducens	NNP
cord-022594-fx044gcd	259	2	paresis	paresis	NN
cord-022594-fx044gcd	259	3	occurs	occur	VBZ
cord-022594-fx044gcd	259	4	on	on	IN
cord-022594-fx044gcd	259	5	occasion	occasion	NN
cord-022594-fx044gcd	259	6	,	,	,
cord-022594-fx044gcd	259	7	but	but	CC
cord-022594-fx044gcd	259	8	oculomotor	oculomotor	NN
cord-022594-fx044gcd	259	9	and	and	CC
cord-022594-fx044gcd	259	10	trochlear	trochlear	JJ
cord-022594-fx044gcd	259	11	nerve	nerve	NN
cord-022594-fx044gcd	259	12	impairment	impairment	NN
cord-022594-fx044gcd	259	13	is	be	VBZ
cord-022594-fx044gcd	259	14	rare	rare	JJ
cord-022594-fx044gcd	259	15	.	.	.
cord-022594-fx044gcd	260	1	Corticospinal	Corticospinal	NNP
cord-022594-fx044gcd	260	2	,	,	,
cord-022594-fx044gcd	260	3	spinothalamic	spinothalamic	NNP
cord-022594-fx044gcd	260	4	,	,	,
cord-022594-fx044gcd	260	5	lemniscal	lemniscal	NNP
cord-022594-fx044gcd	260	6	,	,	,
cord-022594-fx044gcd	260	7	vestibular	vestibular	NN
cord-022594-fx044gcd	260	8	,	,	,
cord-022594-fx044gcd	260	9	and	and	CC
cord-022594-fx044gcd	260	10	cerebellar	cerebellar	JJ
cord-022594-fx044gcd	260	11	pathways	pathway	NNS
cord-022594-fx044gcd	260	12	can	can	MD
cord-022594-fx044gcd	260	13	all	all	DT
cord-022594-fx044gcd	260	14	be	be	VB
cord-022594-fx044gcd	260	15	affected	affect	VBN
cord-022594-fx044gcd	260	16	.	.	.
cord-022594-fx044gcd	261	1	Cranial	cranial	JJ
cord-022594-fx044gcd	261	2	nerve	nerve	NN
cord-022594-fx044gcd	261	3	impairment	impairment	NN
cord-022594-fx044gcd	261	4	may	may	MD
cord-022594-fx044gcd	261	5	be	be	VB
cord-022594-fx044gcd	261	6	seen	see	VBN
cord-022594-fx044gcd	261	7	with	with	IN
cord-022594-fx044gcd	261	8	lesions	lesion	NNS
cord-022594-fx044gcd	261	9	that	that	WDT
cord-022594-fx044gcd	261	10	affect	affect	VBP
cord-022594-fx044gcd	261	11	brain	brain	NN
cord-022594-fx044gcd	261	12	stem	stem	NN
cord-022594-fx044gcd	261	13	nuclei	nucleus	NNS
cord-022594-fx044gcd	261	14	or	or	CC
cord-022594-fx044gcd	261	15	exiting	exit	VBG
cord-022594-fx044gcd	261	16	and	and	CC
cord-022594-fx044gcd	261	17	entering	enter	VBG
cord-022594-fx044gcd	261	18	fibers	fiber	NNS
cord-022594-fx044gcd	261	19	.	.	.
cord-022594-fx044gcd	262	1	Usually	usually	RB
cord-022594-fx044gcd	262	2	this	this	DT
cord-022594-fx044gcd	262	3	occurs	occur	VBZ
cord-022594-fx044gcd	262	4	in	in	IN
cord-022594-fx044gcd	262	5	association	association	NN
cord-022594-fx044gcd	262	6	with	with	IN
cord-022594-fx044gcd	262	7	other	other	JJ
cord-022594-fx044gcd	262	8	symptoms	symptom	NNS
cord-022594-fx044gcd	262	9	.	.	.
cord-022594-fx044gcd	263	1	Because	because	IN
cord-022594-fx044gcd	263	2	of	of	IN
cord-022594-fx044gcd	263	3	the	the	DT
cord-022594-fx044gcd	263	4	long	long	JJ
cord-022594-fx044gcd	263	5	spinal	spinal	JJ
cord-022594-fx044gcd	263	6	tract	tract	NN
cord-022594-fx044gcd	263	7	and	and	CC
cord-022594-fx044gcd	263	8	nucleus	nucleus	NN
cord-022594-fx044gcd	263	9	,	,	,
cord-022594-fx044gcd	263	10	the	the	DT
cord-022594-fx044gcd	263	11	trigeminal	trigeminal	JJ
cord-022594-fx044gcd	263	12	nerve	nerve	NN
cord-022594-fx044gcd	263	13	is	be	VBZ
cord-022594-fx044gcd	263	14	frequently	frequently	RB
cord-022594-fx044gcd	263	15	involved	involve	VBN
cord-022594-fx044gcd	263	16	(	(	-LRB-
cord-022594-fx044gcd	263	17	Video	Video	NNP
cord-022594-fx044gcd	263	18	106	106	CD
cord-022594-fx044gcd	263	19	,	,	,
cord-022594-fx044gcd	263	20	Trigeminal	Trigeminal	NNP
cord-022594-fx044gcd	263	21	Neuralgia	Neuralgia	NNP
cord-022594-fx044gcd	263	22	)	)	-RRB-
cord-022594-fx044gcd	263	23	.	.	.
cord-022594-fx044gcd	264	1	Facial	facial	JJ
cord-022594-fx044gcd	264	2	nerve	nerve	NN
cord-022594-fx044gcd	264	3	paresis	paresis	NN
cord-022594-fx044gcd	264	4	does	do	VBZ
cord-022594-fx044gcd	264	5	occasionally	occasionally	RB
cord-022594-fx044gcd	264	6	occur	occur	VB
cord-022594-fx044gcd	264	7	,	,	,
cord-022594-fx044gcd	264	8	but	but	CC
cord-022594-fx044gcd	264	9	MS	MS	NNP
cord-022594-fx044gcd	264	10	is	be	VBZ
cord-022594-fx044gcd	264	11	an	an	DT
cord-022594-fx044gcd	264	12	extremely	extremely	RB
cord-022594-fx044gcd	264	13	rare	rare	JJ
cord-022594-fx044gcd	264	14	cause	cause	NN
cord-022594-fx044gcd	264	15	of	of	IN
cord-022594-fx044gcd	264	16	Bell	Bell	NNP
cord-022594-fx044gcd	264	17	's	's	POS
cord-022594-fx044gcd	264	18	palsy	palsy	NN
cord-022594-fx044gcd	264	19	in	in	IN
cord-022594-fx044gcd	264	20	patients	patient	NNS
cord-022594-fx044gcd	264	21	without	without	IN
cord-022594-fx044gcd	264	22	previous	previous	JJ
cord-022594-fx044gcd	264	23	symptoms	symptom	NNS
cord-022594-fx044gcd	264	24	.	.	.
cord-022594-fx044gcd	265	1	Acute	acute	JJ
cord-022594-fx044gcd	265	2	unilateral	unilateral	JJ
cord-022594-fx044gcd	265	3	hearing	hearing	NN
cord-022594-fx044gcd	265	4	loss	loss	NN
cord-022594-fx044gcd	265	5	is	be	VBZ
cord-022594-fx044gcd	265	6	an	an	DT
cord-022594-fx044gcd	265	7	uncommon	uncommon	JJ
cord-022594-fx044gcd	265	8	manifestation	manifestation	NN
cord-022594-fx044gcd	265	9	.	.	.
cord-022594-fx044gcd	266	1	Dysphagia	Dysphagia	NNP
cord-022594-fx044gcd	266	2	is	be	VBZ
cord-022594-fx044gcd	266	3	often	often	RB
cord-022594-fx044gcd	266	4	due	due	JJ
cord-022594-fx044gcd	266	5	to	to	IN
cord-022594-fx044gcd	266	6	impairment	impairment	NN
cord-022594-fx044gcd	266	7	of	of	IN
cord-022594-fx044gcd	266	8	cranial	cranial	JJ
cord-022594-fx044gcd	266	9	nerves	nerve	NNS
cord-022594-fx044gcd	266	10	IX	IX	NNP
cord-022594-fx044gcd	266	11	,	,	,
cord-022594-fx044gcd	266	12	X	X	NNP
cord-022594-fx044gcd	266	13	,	,	,
cord-022594-fx044gcd	266	14	and	and	CC
cord-022594-fx044gcd	266	15	XII	XII	NNP
cord-022594-fx044gcd	266	16	and	and	CC
cord-022594-fx044gcd	266	17	generally	generally	RB
cord-022594-fx044gcd	266	18	appears	appear	VBZ
cord-022594-fx044gcd	266	19	late	late	RB
cord-022594-fx044gcd	266	20	in	in	IN
cord-022594-fx044gcd	266	21	the	the	DT
cord-022594-fx044gcd	266	22	course	course	NN
cord-022594-fx044gcd	266	23	of	of	IN
cord-022594-fx044gcd	266	24	some	some	DT
cord-022594-fx044gcd	266	25	patients	patient	NNS
cord-022594-fx044gcd	266	26	.	.	.
cord-022594-fx044gcd	267	1	Once	once	RB
cord-022594-fx044gcd	267	2	thought	think	VBD
cord-022594-fx044gcd	267	3	uncommon	uncommon	JJ
cord-022594-fx044gcd	267	4	,	,	,
cord-022594-fx044gcd	267	5	cognitive	cognitive	JJ
cord-022594-fx044gcd	267	6	disorders	disorder	NNS
cord-022594-fx044gcd	267	7	are	be	VBP
cord-022594-fx044gcd	267	8	now	now	RB
cord-022594-fx044gcd	267	9	known	know	VBN
cord-022594-fx044gcd	267	10	to	to	TO
cord-022594-fx044gcd	267	11	be	be	VB
cord-022594-fx044gcd	267	12	present	present	JJ
cord-022594-fx044gcd	267	13	in	in	IN
cord-022594-fx044gcd	267	14	40	40	CD
cord-022594-fx044gcd	267	15	%	%	NN
cord-022594-fx044gcd	267	16	to	to	TO
cord-022594-fx044gcd	267	17	70	70	CD
cord-022594-fx044gcd	267	18	%	%	NN
cord-022594-fx044gcd	267	19	of	of	IN
cord-022594-fx044gcd	267	20	MS	MS	NNP
cord-022594-fx044gcd	267	21	patients	patient	NNS
cord-022594-fx044gcd	267	22	.	.	.
cord-022594-fx044gcd	268	1	31	31	CD
cord-022594-fx044gcd	268	2	Age	age	NN
cord-022594-fx044gcd	268	3	,	,	,
cord-022594-fx044gcd	268	4	duration	duration	NN
cord-022594-fx044gcd	268	5	of	of	IN
cord-022594-fx044gcd	268	6	MS	MS	NNP
cord-022594-fx044gcd	268	7	,	,	,
cord-022594-fx044gcd	268	8	and	and	CC
cord-022594-fx044gcd	268	9	physical	physical	JJ
cord-022594-fx044gcd	268	10	disability	disability	NN
cord-022594-fx044gcd	268	11	do	do	VBP
cord-022594-fx044gcd	268	12	not	not	RB
cord-022594-fx044gcd	268	13	completely	completely	RB
cord-022594-fx044gcd	268	14	predict	predict	VB
cord-022594-fx044gcd	268	15	the	the	DT
cord-022594-fx044gcd	268	16	presence	presence	NN
cord-022594-fx044gcd	268	17	of	of	IN
cord-022594-fx044gcd	268	18	cognitive	cognitive	JJ
cord-022594-fx044gcd	268	19	dysfunction	dysfunction	NN
cord-022594-fx044gcd	268	20	,	,	,
cord-022594-fx044gcd	268	21	but	but	CC
cord-022594-fx044gcd	268	22	classic	classic	JJ
cord-022594-fx044gcd	268	23	MRI	MRI	NNP
cord-022594-fx044gcd	268	24	measures	measure	NNS
cord-022594-fx044gcd	268	25	like	like	IN
cord-022594-fx044gcd	268	26	the	the	DT
cord-022594-fx044gcd	268	27	total	total	JJ
cord-022594-fx044gcd	268	28	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	268	29	lesion	lesion	NN
cord-022594-fx044gcd	268	30	load	load	NN
cord-022594-fx044gcd	268	31	does	do	VBZ
cord-022594-fx044gcd	268	32	not	not	RB
cord-022594-fx044gcd	268	33	seem	seem	VB
cord-022594-fx044gcd	268	34	to	to	TO
cord-022594-fx044gcd	268	35	correlate	correlate	VB
cord-022594-fx044gcd	268	36	well	well	RB
cord-022594-fx044gcd	268	37	with	with	IN
cord-022594-fx044gcd	268	38	the	the	DT
cord-022594-fx044gcd	268	39	degree	degree	NN
cord-022594-fx044gcd	268	40	of	of	IN
cord-022594-fx044gcd	268	41	cognitive	cognitive	JJ
cord-022594-fx044gcd	268	42	decline	decline	NN
cord-022594-fx044gcd	268	43	.	.	.
cord-022594-fx044gcd	269	1	Measures	measure	NNS
cord-022594-fx044gcd	269	2	of	of	IN
cord-022594-fx044gcd	269	3	cortical	cortical	JJ
cord-022594-fx044gcd	269	4	atrophy	atrophy	NN
cord-022594-fx044gcd	269	5	,	,	,
cord-022594-fx044gcd	269	6	venticular	venticular	JJ
cord-022594-fx044gcd	269	7	enlargement	enlargement	NN
cord-022594-fx044gcd	269	8	,	,	,
cord-022594-fx044gcd	269	9	and	and	CC
cord-022594-fx044gcd	269	10	neuronal	neuronal	JJ
cord-022594-fx044gcd	269	11	integrity	integrity	NN
cord-022594-fx044gcd	269	12	seem	seem	VBP
cord-022594-fx044gcd	269	13	to	to	TO
cord-022594-fx044gcd	269	14	correlate	correlate	VB
cord-022594-fx044gcd	269	15	better	well	RBR
cord-022594-fx044gcd	269	16	with	with	IN
cord-022594-fx044gcd	269	17	the	the	DT
cord-022594-fx044gcd	269	18	cognitive	cognitive	JJ
cord-022594-fx044gcd	269	19	aspects	aspect	NNS
cord-022594-fx044gcd	269	20	of	of	IN
cord-022594-fx044gcd	269	21	MS	MS	NNP
cord-022594-fx044gcd	269	22	.	.	.
cord-022594-fx044gcd	270	1	The	the	DT
cord-022594-fx044gcd	270	2	problems	problem	NNS
cord-022594-fx044gcd	270	3	are	be	VBP
cord-022594-fx044gcd	270	4	often	often	RB
cord-022594-fx044gcd	270	5	subtle	subtle	JJ
cord-022594-fx044gcd	270	6	and	and	CC
cord-022594-fx044gcd	270	7	may	may	MD
cord-022594-fx044gcd	270	8	not	not	RB
cord-022594-fx044gcd	270	9	be	be	VB
cord-022594-fx044gcd	270	10	detected	detect	VBN
cord-022594-fx044gcd	270	11	on	on	IN
cord-022594-fx044gcd	270	12	standard	standard	JJ
cord-022594-fx044gcd	270	13	mental	mental	JJ
cord-022594-fx044gcd	270	14	status	status	NN
cord-022594-fx044gcd	270	15	evaluation	evaluation	NN
cord-022594-fx044gcd	270	16	.	.	.
cord-022594-fx044gcd	271	1	The	the	DT
cord-022594-fx044gcd	271	2	pattern	pattern	NN
cord-022594-fx044gcd	271	3	of	of	IN
cord-022594-fx044gcd	271	4	cognitive	cognitive	JJ
cord-022594-fx044gcd	271	5	decline	decline	NN
cord-022594-fx044gcd	271	6	is	be	VBZ
cord-022594-fx044gcd	271	7	typified	typify	VBN
cord-022594-fx044gcd	271	8	by	by	IN
cord-022594-fx044gcd	271	9	decrease	decrease	NN
cord-022594-fx044gcd	271	10	of	of	IN
cord-022594-fx044gcd	271	11	episodic	episodic	JJ
cord-022594-fx044gcd	271	12	memory	memory	NN
cord-022594-fx044gcd	271	13	,	,	,
cord-022594-fx044gcd	271	14	processing	processing	NN
cord-022594-fx044gcd	271	15	speed	speed	NN
cord-022594-fx044gcd	271	16	,	,	,
cord-022594-fx044gcd	271	17	verbal	verbal	JJ
cord-022594-fx044gcd	271	18	fluency	fluency	NN
cord-022594-fx044gcd	271	19	,	,	,
cord-022594-fx044gcd	271	20	and	and	CC
cord-022594-fx044gcd	271	21	difficulty	difficulty	NN
cord-022594-fx044gcd	271	22	with	with	IN
cord-022594-fx044gcd	271	23	abstract	abstract	JJ
cord-022594-fx044gcd	271	24	concepts	concept	NNS
cord-022594-fx044gcd	271	25	and	and	CC
cord-022594-fx044gcd	271	26	complex	complex	JJ
cord-022594-fx044gcd	271	27	reasoning	reasoning	NN
cord-022594-fx044gcd	271	28	.	.	.
cord-022594-fx044gcd	272	1	To	to	IN
cord-022594-fx044gcd	272	2	a	a	DT
cord-022594-fx044gcd	272	3	lesser	less	JJR
cord-022594-fx044gcd	272	4	extent	extent	NN
cord-022594-fx044gcd	272	5	,	,	,
cord-022594-fx044gcd	272	6	executive	executive	JJ
cord-022594-fx044gcd	272	7	functioning	functioning	NN
cord-022594-fx044gcd	272	8	and	and	CC
cord-022594-fx044gcd	272	9	visual	visual	JJ
cord-022594-fx044gcd	272	10	perception	perception	NN
cord-022594-fx044gcd	272	11	,	,	,
cord-022594-fx044gcd	272	12	semantic	semantic	JJ
cord-022594-fx044gcd	272	13	memory	memory	NN
cord-022594-fx044gcd	272	14	,	,	,
cord-022594-fx044gcd	272	15	and	and	CC
cord-022594-fx044gcd	272	16	attention	attention	NN
cord-022594-fx044gcd	272	17	span	span	NN
cord-022594-fx044gcd	272	18	may	may	MD
cord-022594-fx044gcd	272	19	also	also	RB
cord-022594-fx044gcd	272	20	be	be	VB
cord-022594-fx044gcd	272	21	also	also	RB
cord-022594-fx044gcd	272	22	decreased	decrease	VBN
cord-022594-fx044gcd	272	23	.	.	.
cord-022594-fx044gcd	273	1	General	general	JJ
cord-022594-fx044gcd	273	2	intelligence	intelligence	NN
cord-022594-fx044gcd	273	3	is	be	VBZ
cord-022594-fx044gcd	273	4	not	not	RB
cord-022594-fx044gcd	273	5	typically	typically	RB
cord-022594-fx044gcd	273	6	affected	affect	VBN
cord-022594-fx044gcd	273	7	.	.	.
cord-022594-fx044gcd	274	1	As	as	IN
cord-022594-fx044gcd	274	2	expected	expect	VBN
cord-022594-fx044gcd	274	3	,	,	,
cord-022594-fx044gcd	274	4	cortical	cortical	JJ
cord-022594-fx044gcd	274	5	symptoms	symptom	NNS
cord-022594-fx044gcd	274	6	such	such	JJ
cord-022594-fx044gcd	274	7	as	as	IN
cord-022594-fx044gcd	274	8	aphasia	aphasia	NNP
cord-022594-fx044gcd	274	9	,	,	,
cord-022594-fx044gcd	274	10	apraxia	apraxia	NN
cord-022594-fx044gcd	274	11	,	,	,
cord-022594-fx044gcd	274	12	and	and	CC
cord-022594-fx044gcd	274	13	agnosia	agnosia	NN
cord-022594-fx044gcd	274	14	are	be	VBP
cord-022594-fx044gcd	274	15	unusual	unusual	JJ
cord-022594-fx044gcd	274	16	.	.	.
cord-022594-fx044gcd	275	1	Homonymous	Homonymous	NNP
cord-022594-fx044gcd	275	2	hemianopia	hemianopia	RB
cord-022594-fx044gcd	275	3	,	,	,
cord-022594-fx044gcd	275	4	which	which	WDT
cord-022594-fx044gcd	275	5	can	can	MD
cord-022594-fx044gcd	275	6	be	be	VB
cord-022594-fx044gcd	275	7	caused	cause	VBN
cord-022594-fx044gcd	275	8	by	by	IN
cord-022594-fx044gcd	275	9	cortical	cortical	JJ
cord-022594-fx044gcd	275	10	or	or	CC
cord-022594-fx044gcd	275	11	subcortical	subcortical	JJ
cord-022594-fx044gcd	275	12	lesions	lesion	NNS
cord-022594-fx044gcd	275	13	,	,	,
cord-022594-fx044gcd	275	14	is	be	VBZ
cord-022594-fx044gcd	275	15	also	also	RB
cord-022594-fx044gcd	275	16	uncommon	uncommon	JJ
cord-022594-fx044gcd	275	17	.	.	.
cord-022594-fx044gcd	276	1	Despite	despite	IN
cord-022594-fx044gcd	276	2	prominent	prominent	JJ
cord-022594-fx044gcd	276	3	cerebral	cerebral	JJ
cord-022594-fx044gcd	276	4	white	white	JJ
cord-022594-fx044gcd	276	5	matter	matter	NN
cord-022594-fx044gcd	276	6	involvement	involvement	NN
cord-022594-fx044gcd	276	7	,	,	,
cord-022594-fx044gcd	276	8	many	many	JJ
cord-022594-fx044gcd	276	9	of	of	IN
cord-022594-fx044gcd	276	10	the	the	DT
cord-022594-fx044gcd	276	11	disconnection	disconnection	NN
cord-022594-fx044gcd	276	12	syndromes	syndrome	NNS
cord-022594-fx044gcd	276	13	such	such	JJ
cord-022594-fx044gcd	276	14	as	as	IN
cord-022594-fx044gcd	276	15	alexia	alexia	NNP
cord-022594-fx044gcd	276	16	without	without	IN
cord-022594-fx044gcd	276	17	agraphia	agraphia	NNP
cord-022594-fx044gcd	276	18	,	,	,
cord-022594-fx044gcd	276	19	conduction	conduction	NN
cord-022594-fx044gcd	276	20	aphasia	aphasia	NNP
cord-022594-fx044gcd	276	21	,	,	,
cord-022594-fx044gcd	276	22	and	and	CC
cord-022594-fx044gcd	276	23	pure	pure	JJ
cord-022594-fx044gcd	276	24	word	word	NN
cord-022594-fx044gcd	276	25	deafness	deafness	NN
cord-022594-fx044gcd	276	26	have	have	VBP
cord-022594-fx044gcd	276	27	not	not	RB
cord-022594-fx044gcd	276	28	been	be	VBN
cord-022594-fx044gcd	276	29	reported	report	VBN
cord-022594-fx044gcd	276	30	in	in	IN
cord-022594-fx044gcd	276	31	MS	MS	NNP
cord-022594-fx044gcd	276	32	patients	patient	NNS
cord-022594-fx044gcd	276	33	.	.	.
cord-022594-fx044gcd	277	1	Affective	affective	JJ
cord-022594-fx044gcd	277	2	disorders	disorder	NNS
cord-022594-fx044gcd	277	3	are	be	VBP
cord-022594-fx044gcd	277	4	more	more	RBR
cord-022594-fx044gcd	277	5	frequent	frequent	JJ
cord-022594-fx044gcd	277	6	in	in	IN
cord-022594-fx044gcd	277	7	MS	MS	NNP
cord-022594-fx044gcd	277	8	patients	patient	NNS
cord-022594-fx044gcd	277	9	than	than	IN
cord-022594-fx044gcd	277	10	in	in	IN
cord-022594-fx044gcd	277	11	the	the	DT
cord-022594-fx044gcd	277	12	general	general	JJ
cord-022594-fx044gcd	277	13	population	population	NN
cord-022594-fx044gcd	277	14	.	.	.
cord-022594-fx044gcd	278	1	These	these	DT
cord-022594-fx044gcd	278	2	include	include	VBP
cord-022594-fx044gcd	278	3	both	both	DT
cord-022594-fx044gcd	278	4	anxiety	anxiety	NN
cord-022594-fx044gcd	278	5	and	and	CC
cord-022594-fx044gcd	278	6	depression	depression	NN
cord-022594-fx044gcd	278	7	.	.	.
cord-022594-fx044gcd	279	1	In	in	IN
cord-022594-fx044gcd	279	2	long	long	JJ
cord-022594-fx044gcd	279	3	-	-	HYPH
cord-022594-fx044gcd	279	4	term	term	NN
cord-022594-fx044gcd	279	5	studies	study	NNS
cord-022594-fx044gcd	279	6	,	,	,
cord-022594-fx044gcd	279	7	the	the	DT
cord-022594-fx044gcd	279	8	incidence	incidence	NN
cord-022594-fx044gcd	279	9	of	of	IN
cord-022594-fx044gcd	279	10	depression	depression	NN
cord-022594-fx044gcd	279	11	in	in	IN
cord-022594-fx044gcd	279	12	MS	MS	NNP
cord-022594-fx044gcd	279	13	patients	patient	NNS
cord-022594-fx044gcd	279	14	is	be	VBZ
cord-022594-fx044gcd	279	15	close	close	JJ
cord-022594-fx044gcd	279	16	to	to	TO
cord-022594-fx044gcd	279	17	75	75	CD
cord-022594-fx044gcd	279	18	%	%	NN
cord-022594-fx044gcd	279	19	.	.	.
cord-022594-fx044gcd	280	1	Neither	neither	DT
cord-022594-fx044gcd	280	2	depression	depression	NN
cord-022594-fx044gcd	280	3	nor	nor	CC
cord-022594-fx044gcd	280	4	anxiety	anxiety	NN
cord-022594-fx044gcd	280	5	is	be	VBZ
cord-022594-fx044gcd	280	6	related	relate	VBN
cord-022594-fx044gcd	280	7	to	to	IN
cord-022594-fx044gcd	280	8	physical	physical	JJ
cord-022594-fx044gcd	280	9	or	or	CC
cord-022594-fx044gcd	280	10	cognitive	cognitive	JJ
cord-022594-fx044gcd	280	11	disability	disability	NN
cord-022594-fx044gcd	280	12	or	or	CC
cord-022594-fx044gcd	280	13	MRI	MRI	NNP
cord-022594-fx044gcd	280	14	lesion	lesion	NN
cord-022594-fx044gcd	280	15	load	load	NN
cord-022594-fx044gcd	280	16	.	.	.
cord-022594-fx044gcd	281	1	Patients	patient	NNS
cord-022594-fx044gcd	281	2	sometimes	sometimes	RB
cord-022594-fx044gcd	281	3	experience	experience	VBP
cord-022594-fx044gcd	281	4	uncontrollable	uncontrollable	JJ
cord-022594-fx044gcd	281	5	weeping	weeping	NN
cord-022594-fx044gcd	281	6	or	or	CC
cord-022594-fx044gcd	281	7	less	less	RBR
cord-022594-fx044gcd	281	8	commonly	commonly	RB
cord-022594-fx044gcd	281	9	laughter	laughter	NN
cord-022594-fx044gcd	281	10	incongruent	incongruent	JJ
cord-022594-fx044gcd	281	11	with	with	IN
cord-022594-fx044gcd	281	12	their	-PRON-	PRP$
cord-022594-fx044gcd	281	13	mood	mood	NN
cord-022594-fx044gcd	281	14	.	.	.
cord-022594-fx044gcd	282	1	Interruption	interruption	NN
cord-022594-fx044gcd	282	2	of	of	IN
cord-022594-fx044gcd	282	3	inhibitory	inhibitory	JJ
cord-022594-fx044gcd	282	4	corticobulbar	corticobulbar	NN
cord-022594-fx044gcd	282	5	fibers	fiber	NNS
cord-022594-fx044gcd	282	6	is	be	VBZ
cord-022594-fx044gcd	282	7	responsible	responsible	JJ
cord-022594-fx044gcd	282	8	for	for	IN
cord-022594-fx044gcd	282	9	these	these	DT
cord-022594-fx044gcd	282	10	symptoms	symptom	NNS
cord-022594-fx044gcd	282	11	(	(	-LRB-
cord-022594-fx044gcd	282	12	pseudobulbar	pseudobulbar	NNP
cord-022594-fx044gcd	282	13	affect	affect	NN
cord-022594-fx044gcd	282	14	)	)	-RRB-
cord-022594-fx044gcd	282	15	.	.	.
cord-022594-fx044gcd	283	1	Fatigue	fatigue	NN
cord-022594-fx044gcd	283	2	is	be	VBZ
cord-022594-fx044gcd	283	3	a	a	DT
cord-022594-fx044gcd	283	4	pervasive	pervasive	JJ
cord-022594-fx044gcd	283	5	symptom	symptom	NN
cord-022594-fx044gcd	283	6	among	among	IN
cord-022594-fx044gcd	283	7	MS	MS	NNP
cord-022594-fx044gcd	283	8	patients	patient	NNS
cord-022594-fx044gcd	283	9	that	that	WDT
cord-022594-fx044gcd	283	10	is	be	VBZ
cord-022594-fx044gcd	283	11	not	not	RB
cord-022594-fx044gcd	283	12	related	relate	VBN
cord-022594-fx044gcd	283	13	to	to	IN
cord-022594-fx044gcd	283	14	disability	disability	NN
cord-022594-fx044gcd	283	15	or	or	CC
cord-022594-fx044gcd	283	16	depression	depression	NN
cord-022594-fx044gcd	283	17	.	.	.
cord-022594-fx044gcd	284	1	Over	over	IN
cord-022594-fx044gcd	284	2	75	75	CD
cord-022594-fx044gcd	284	3	%	%	NN
cord-022594-fx044gcd	284	4	of	of	IN
cord-022594-fx044gcd	284	5	MS	MS	NNP
cord-022594-fx044gcd	284	6	patients	patient	NNS
cord-022594-fx044gcd	284	7	experience	experience	NN
cord-022594-fx044gcd	284	8	fatigue	fatigue	NN
cord-022594-fx044gcd	284	9	during	during	IN
cord-022594-fx044gcd	284	10	their	-PRON-	PRP$
cord-022594-fx044gcd	284	11	disease	disease	NN
cord-022594-fx044gcd	284	12	course	course	NN
cord-022594-fx044gcd	284	13	.	.	.
cord-022594-fx044gcd	285	1	A	a	DT
cord-022594-fx044gcd	285	2	diurnal	diurnal	JJ
cord-022594-fx044gcd	285	3	pattern	pattern	NN
cord-022594-fx044gcd	285	4	is	be	VBZ
cord-022594-fx044gcd	285	5	characteristic	characteristic	JJ
cord-022594-fx044gcd	285	6	and	and	CC
cord-022594-fx044gcd	285	7	follows	follow	VBZ
cord-022594-fx044gcd	285	8	the	the	DT
cord-022594-fx044gcd	285	9	normal	normal	JJ
cord-022594-fx044gcd	285	10	circadian	circadian	NN
cord-022594-fx044gcd	285	11	pattern	pattern	NN
cord-022594-fx044gcd	285	12	of	of	IN
cord-022594-fx044gcd	285	13	body	body	NN
cord-022594-fx044gcd	285	14	temperature	temperature	NN
cord-022594-fx044gcd	285	15	fluctuations	fluctuation	NNS
cord-022594-fx044gcd	285	16	,	,	,
cord-022594-fx044gcd	285	17	with	with	IN
cord-022594-fx044gcd	285	18	the	the	DT
cord-022594-fx044gcd	285	19	worse	bad	JJR
cord-022594-fx044gcd	285	20	symptoms	symptom	NNS
cord-022594-fx044gcd	285	21	occurring	occur	VBG
cord-022594-fx044gcd	285	22	in	in	IN
cord-022594-fx044gcd	285	23	afternoon	afternoon	NN
cord-022594-fx044gcd	285	24	hours	hour	NNS
cord-022594-fx044gcd	285	25	(	(	-LRB-
cord-022594-fx044gcd	285	26	peak	peak	JJ
cord-022594-fx044gcd	285	27	core	core	NN
cord-022594-fx044gcd	285	28	body	body	NN
cord-022594-fx044gcd	285	29	temperature	temperature	NN
cord-022594-fx044gcd	285	30	)	)	-RRB-
cord-022594-fx044gcd	285	31	often	often	RB
cord-022594-fx044gcd	285	32	giving	give	VBG
cord-022594-fx044gcd	285	33	way	way	NN
cord-022594-fx044gcd	285	34	to	to	IN
cord-022594-fx044gcd	285	35	improvement	improvement	NN
cord-022594-fx044gcd	285	36	in	in	IN
cord-022594-fx044gcd	285	37	the	the	DT
cord-022594-fx044gcd	285	38	late	late	JJ
cord-022594-fx044gcd	285	39	evening	evening	NN
cord-022594-fx044gcd	285	40	.	.	.
cord-022594-fx044gcd	286	1	MS	MS	NNP
cord-022594-fx044gcd	286	2	symptoms	symptom	NNS
cord-022594-fx044gcd	286	3	may	may	MD
cord-022594-fx044gcd	286	4	fluctuate	fluctuate	VB
cord-022594-fx044gcd	286	5	in	in	IN
cord-022594-fx044gcd	286	6	a	a	DT
cord-022594-fx044gcd	286	7	predictable	predictable	JJ
cord-022594-fx044gcd	286	8	fashion	fashion	NN
cord-022594-fx044gcd	286	9	.	.	.
cord-022594-fx044gcd	287	1	Transient	transient	JJ
cord-022594-fx044gcd	287	2	worsening	worsening	NN
cord-022594-fx044gcd	287	3	of	of	IN
cord-022594-fx044gcd	287	4	symptoms	symptom	NNS
cord-022594-fx044gcd	287	5	frequently	frequently	RB
cord-022594-fx044gcd	287	6	follows	follow	VBZ
cord-022594-fx044gcd	287	7	exercise	exercise	NN
cord-022594-fx044gcd	287	8	or	or	CC
cord-022594-fx044gcd	287	9	elevation	elevation	NN
cord-022594-fx044gcd	287	10	of	of	IN
cord-022594-fx044gcd	287	11	body	body	NN
cord-022594-fx044gcd	287	12	temperature	temperature	NN
cord-022594-fx044gcd	287	13	.	.	.
cord-022594-fx044gcd	288	1	One	one	CD
cord-022594-fx044gcd	288	2	example	example	NN
cord-022594-fx044gcd	288	3	is	be	VBZ
cord-022594-fx044gcd	288	4	Uhtoff	Uhtoff	NNP
cord-022594-fx044gcd	288	5	's	's	POS
cord-022594-fx044gcd	288	6	phenomenon	phenomenon	NN
cord-022594-fx044gcd	288	7	,	,	,
cord-022594-fx044gcd	288	8	in	in	IN
cord-022594-fx044gcd	288	9	which	which	WDT
cord-022594-fx044gcd	288	10	visual	visual	JJ
cord-022594-fx044gcd	288	11	blurring	blurring	NN
cord-022594-fx044gcd	288	12	occurs	occur	VBZ
cord-022594-fx044gcd	288	13	during	during	IN
cord-022594-fx044gcd	288	14	strenuous	strenuous	JJ
cord-022594-fx044gcd	288	15	activity	activity	NN
cord-022594-fx044gcd	288	16	or	or	CC
cord-022594-fx044gcd	288	17	with	with	IN
cord-022594-fx044gcd	288	18	passive	passive	JJ
cord-022594-fx044gcd	288	19	exposure	exposure	NN
cord-022594-fx044gcd	288	20	to	to	IN
cord-022594-fx044gcd	288	21	heat	heat	NN
cord-022594-fx044gcd	288	22	.	.	.
cord-022594-fx044gcd	289	1	These	these	DT
cord-022594-fx044gcd	289	2	episodes	episode	NNS
cord-022594-fx044gcd	289	3	resolve	resolve	VBP
cord-022594-fx044gcd	289	4	when	when	WRB
cord-022594-fx044gcd	289	5	the	the	DT
cord-022594-fx044gcd	289	6	body	body	NN
cord-022594-fx044gcd	289	7	temperature	temperature	NN
cord-022594-fx044gcd	289	8	cools	cool	VBZ
cord-022594-fx044gcd	289	9	to	to	IN
cord-022594-fx044gcd	289	10	normal	normal	JJ
cord-022594-fx044gcd	289	11	or	or	CC
cord-022594-fx044gcd	289	12	after	after	IN
cord-022594-fx044gcd	289	13	a	a	DT
cord-022594-fx044gcd	289	14	period	period	NN
cord-022594-fx044gcd	289	15	of	of	IN
cord-022594-fx044gcd	289	16	rest	rest	NN
cord-022594-fx044gcd	289	17	.	.	.
cord-022594-fx044gcd	290	1	An	an	DT
cord-022594-fx044gcd	290	2	intercurrent	intercurrent	NN
cord-022594-fx044gcd	290	3	infection	infection	NN
cord-022594-fx044gcd	290	4	with	with	IN
cord-022594-fx044gcd	290	5	fever	fever	NN
cord-022594-fx044gcd	290	6	can	can	MD
cord-022594-fx044gcd	290	7	induce	induce	VB
cord-022594-fx044gcd	290	8	worsening	worsen	VBG
cord-022594-fx044gcd	290	9	of	of	IN
cord-022594-fx044gcd	290	10	symptoms	symptom	NNS
cord-022594-fx044gcd	290	11	and	and	CC
cord-022594-fx044gcd	290	12	may	may	MD
cord-022594-fx044gcd	290	13	be	be	VB
cord-022594-fx044gcd	290	14	confused	confuse	VBN
cord-022594-fx044gcd	290	15	with	with	IN
cord-022594-fx044gcd	290	16	a	a	DT
cord-022594-fx044gcd	290	17	relapse	relapse	NN
cord-022594-fx044gcd	290	18	.	.	.
cord-022594-fx044gcd	291	1	Heat	heat	NN
cord-022594-fx044gcd	291	2	sensitivity	sensitivity	NN
cord-022594-fx044gcd	291	3	is	be	VBZ
cord-022594-fx044gcd	291	4	presumably	presumably	RB
cord-022594-fx044gcd	291	5	related	relate	VBN
cord-022594-fx044gcd	291	6	to	to	IN
cord-022594-fx044gcd	291	7	conduction	conduction	NN
cord-022594-fx044gcd	291	8	block	block	NN
cord-022594-fx044gcd	291	9	,	,	,
cord-022594-fx044gcd	291	10	as	as	IN
cord-022594-fx044gcd	291	11	demyelinated	demyelinate	VBN
cord-022594-fx044gcd	291	12	axons	axon	NNS
cord-022594-fx044gcd	291	13	are	be	VBP
cord-022594-fx044gcd	291	14	more	more	RBR
cord-022594-fx044gcd	291	15	prone	prone	JJ
cord-022594-fx044gcd	291	16	to	to	IN
cord-022594-fx044gcd	291	17	failed	fail	VBN
cord-022594-fx044gcd	291	18	conduction	conduction	NN
cord-022594-fx044gcd	291	19	than	than	IN
cord-022594-fx044gcd	291	20	normal	normal	JJ
cord-022594-fx044gcd	291	21	,	,	,
cord-022594-fx044gcd	291	22	myelinated	myelinated	JJ
cord-022594-fx044gcd	291	23	fibers	fiber	NNS
cord-022594-fx044gcd	291	24	.	.	.
cord-022594-fx044gcd	292	1	32	32	CD
cord-022594-fx044gcd	292	2	Paroxysmal	Paroxysmal	NNP
cord-022594-fx044gcd	292	3	symptoms	symptom	NNS
cord-022594-fx044gcd	292	4	are	be	VBP
cord-022594-fx044gcd	292	5	characteristic	characteristic	JJ
cord-022594-fx044gcd	292	6	of	of	IN
cord-022594-fx044gcd	292	7	MS	MS	NNP
cord-022594-fx044gcd	292	8	and	and	CC
cord-022594-fx044gcd	292	9	are	be	VBP
cord-022594-fx044gcd	292	10	believed	believe	VBN
cord-022594-fx044gcd	292	11	to	to	TO
cord-022594-fx044gcd	292	12	be	be	VB
cord-022594-fx044gcd	292	13	due	due	JJ
cord-022594-fx044gcd	292	14	to	to	IN
cord-022594-fx044gcd	292	15	the	the	DT
cord-022594-fx044gcd	292	16	lateral	lateral	JJ
cord-022594-fx044gcd	292	17	spread	spread	NN
cord-022594-fx044gcd	292	18	of	of	IN
cord-022594-fx044gcd	292	19	excitation	excitation	NN
cord-022594-fx044gcd	292	20	(	(	-LRB-
cord-022594-fx044gcd	292	21	ephaptic	ephaptic	JJ
cord-022594-fx044gcd	292	22	transmission	transmission	NN
cord-022594-fx044gcd	292	23	)	)	-RRB-
cord-022594-fx044gcd	292	24	between	between	IN
cord-022594-fx044gcd	292	25	denuded	denuded	JJ
cord-022594-fx044gcd	292	26	axons	axon	NNS
cord-022594-fx044gcd	292	27	in	in	IN
cord-022594-fx044gcd	292	28	areas	area	NNS
cord-022594-fx044gcd	292	29	of	of	IN
cord-022594-fx044gcd	292	30	demyelination	demyelination	NN
cord-022594-fx044gcd	292	31	.	.	.
cord-022594-fx044gcd	293	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	293	2	are	be	VBP
cord-022594-fx044gcd	293	3	typically	typically	RB
cord-022594-fx044gcd	293	4	brief	brief	JJ
cord-022594-fx044gcd	293	5	(	(	-LRB-
cord-022594-fx044gcd	293	6	seconds	second	NNS
cord-022594-fx044gcd	293	7	to	to	IN
cord-022594-fx044gcd	293	8	2	2	CD
cord-022594-fx044gcd	293	9	minutes	minute	NNS
cord-022594-fx044gcd	293	10	)	)	-RRB-
cord-022594-fx044gcd	293	11	and	and	CC
cord-022594-fx044gcd	293	12	recur	recur	VBP
cord-022594-fx044gcd	293	13	frequently	frequently	RB
cord-022594-fx044gcd	293	14	,	,	,
cord-022594-fx044gcd	293	15	occasionally	occasionally	RB
cord-022594-fx044gcd	293	16	dozens	dozen	NNS
cord-022594-fx044gcd	293	17	of	of	IN
cord-022594-fx044gcd	293	18	times	time	NNS
cord-022594-fx044gcd	293	19	per	per	IN
cord-022594-fx044gcd	293	20	day	day	NN
cord-022594-fx044gcd	293	21	.	.	.
cord-022594-fx044gcd	294	1	They	-PRON-	PRP
cord-022594-fx044gcd	294	2	may	may	MD
cord-022594-fx044gcd	294	3	be	be	VB
cord-022594-fx044gcd	294	4	precipitated	precipitate	VBN
cord-022594-fx044gcd	294	5	by	by	IN
cord-022594-fx044gcd	294	6	hyperventilation	hyperventilation	NN
cord-022594-fx044gcd	294	7	,	,	,
cord-022594-fx044gcd	294	8	certain	certain	JJ
cord-022594-fx044gcd	294	9	sensory	sensory	JJ
cord-022594-fx044gcd	294	10	input	input	NN
cord-022594-fx044gcd	294	11	,	,	,
cord-022594-fx044gcd	294	12	or	or	CC
cord-022594-fx044gcd	294	13	particular	particular	JJ
cord-022594-fx044gcd	294	14	postures	posture	NNS
cord-022594-fx044gcd	294	15	.	.	.
cord-022594-fx044gcd	295	1	Tonic	tonic	NN
cord-022594-fx044gcd	295	2	spasms	spasm	NNS
cord-022594-fx044gcd	295	3	(	(	-LRB-
cord-022594-fx044gcd	295	4	paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	295	5	dystonia	dystonia	NN
cord-022594-fx044gcd	295	6	)	)	-RRB-
cord-022594-fx044gcd	295	7	most	most	RBS
cord-022594-fx044gcd	295	8	often	often	RB
cord-022594-fx044gcd	295	9	affect	affect	VBP
cord-022594-fx044gcd	295	10	the	the	DT
cord-022594-fx044gcd	295	11	arm	arm	NN
cord-022594-fx044gcd	295	12	and	and	CC
cord-022594-fx044gcd	295	13	leg	leg	NN
cord-022594-fx044gcd	295	14	on	on	IN
cord-022594-fx044gcd	295	15	one	one	CD
cord-022594-fx044gcd	295	16	side	side	NN
cord-022594-fx044gcd	295	17	,	,	,
cord-022594-fx044gcd	295	18	but	but	CC
cord-022594-fx044gcd	295	19	the	the	DT
cord-022594-fx044gcd	295	20	face	face	NN
cord-022594-fx044gcd	295	21	,	,	,
cord-022594-fx044gcd	295	22	one	one	CD
cord-022594-fx044gcd	295	23	limb	limb	NN
cord-022594-fx044gcd	295	24	,	,	,
cord-022594-fx044gcd	295	25	or	or	CC
cord-022594-fx044gcd	295	26	bilateral	bilateral	JJ
cord-022594-fx044gcd	295	27	limbs	limb	NNS
cord-022594-fx044gcd	295	28	are	be	VBP
cord-022594-fx044gcd	295	29	sometimes	sometimes	RB
cord-022594-fx044gcd	295	30	involved	involve	VBN
cord-022594-fx044gcd	295	31	(	(	-LRB-
cord-022594-fx044gcd	295	32	Video	Video	NNP
cord-022594-fx044gcd	295	33	20	20	CD
cord-022594-fx044gcd	295	34	,	,	,
cord-022594-fx044gcd	295	35	Tonic	Tonic	NNP
cord-022594-fx044gcd	295	36	Spasms	Spasms	NNP
cord-022594-fx044gcd	295	37	)	)	-RRB-
cord-022594-fx044gcd	295	38	.	.	.
cord-022594-fx044gcd	296	1	These	these	DT
cord-022594-fx044gcd	296	2	spasms	spasm	NNS
cord-022594-fx044gcd	296	3	may	may	MD
cord-022594-fx044gcd	296	4	result	result	VB
cord-022594-fx044gcd	296	5	from	from	IN
cord-022594-fx044gcd	296	6	lesions	lesion	NNS
cord-022594-fx044gcd	296	7	anywhere	anywhere	RB
cord-022594-fx044gcd	296	8	along	along	IN
cord-022594-fx044gcd	296	9	the	the	DT
cord-022594-fx044gcd	296	10	corticospinal	corticospinal	JJ
cord-022594-fx044gcd	296	11	tract	tract	NN
cord-022594-fx044gcd	296	12	.	.	.
cord-022594-fx044gcd	297	1	They	-PRON-	PRP
cord-022594-fx044gcd	297	2	often	often	RB
cord-022594-fx044gcd	297	3	begin	begin	VBP
cord-022594-fx044gcd	297	4	during	during	IN
cord-022594-fx044gcd	297	5	the	the	DT
cord-022594-fx044gcd	297	6	recovery	recovery	NN
cord-022594-fx044gcd	297	7	phase	phase	NN
cord-022594-fx044gcd	297	8	after	after	IN
cord-022594-fx044gcd	297	9	an	an	DT
cord-022594-fx044gcd	297	10	acute	acute	JJ
cord-022594-fx044gcd	297	11	relapse	relapse	NN
cord-022594-fx044gcd	297	12	and	and	CC
cord-022594-fx044gcd	297	13	remit	remit	VB
cord-022594-fx044gcd	297	14	after	after	IN
cord-022594-fx044gcd	297	15	a	a	DT
cord-022594-fx044gcd	297	16	few	few	JJ
cord-022594-fx044gcd	297	17	months	month	NNS
cord-022594-fx044gcd	297	18	.	.	.
cord-022594-fx044gcd	298	1	Intense	intense	JJ
cord-022594-fx044gcd	298	2	pain	pain	NN
cord-022594-fx044gcd	298	3	and	and	CC
cord-022594-fx044gcd	298	4	ipsilateral	ipsilateral	JJ
cord-022594-fx044gcd	298	5	or	or	CC
cord-022594-fx044gcd	298	6	crossed	crossed	JJ
cord-022594-fx044gcd	298	7	sensory	sensory	JJ
cord-022594-fx044gcd	298	8	symptoms	symptom	NNS
cord-022594-fx044gcd	298	9	may	may	MD
cord-022594-fx044gcd	298	10	accompany	accompany	VB
cord-022594-fx044gcd	298	11	them	-PRON-	PRP
cord-022594-fx044gcd	298	12	.	.	.
cord-022594-fx044gcd	299	1	Paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	299	2	weakness	weakness	NN
cord-022594-fx044gcd	299	3	occurs	occur	VBZ
cord-022594-fx044gcd	299	4	,	,	,
cord-022594-fx044gcd	299	5	but	but	CC
cord-022594-fx044gcd	299	6	it	-PRON-	PRP
cord-022594-fx044gcd	299	7	is	be	VBZ
cord-022594-fx044gcd	299	8	uncommon	uncommon	JJ
cord-022594-fx044gcd	299	9	.	.	.
cord-022594-fx044gcd	300	1	A	a	DT
cord-022594-fx044gcd	300	2	wide	wide	JJ
cord-022594-fx044gcd	300	3	variety	variety	NN
cord-022594-fx044gcd	300	4	of	of	IN
cord-022594-fx044gcd	300	5	paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	300	6	sensory	sensory	JJ
cord-022594-fx044gcd	300	7	symptoms	symptom	NNS
cord-022594-fx044gcd	300	8	may	may	MD
cord-022594-fx044gcd	300	9	occur	occur	VB
cord-022594-fx044gcd	300	10	with	with	IN
cord-022594-fx044gcd	300	11	MS	MS	NNP
cord-022594-fx044gcd	300	12	,	,	,
cord-022594-fx044gcd	300	13	including	include	VBG
cord-022594-fx044gcd	300	14	tingling	tingle	VBG
cord-022594-fx044gcd	300	15	,	,	,
cord-022594-fx044gcd	300	16	prickling	prickling	NN
cord-022594-fx044gcd	300	17	,	,	,
cord-022594-fx044gcd	300	18	burning	burning	NN
cord-022594-fx044gcd	300	19	,	,	,
cord-022594-fx044gcd	300	20	or	or	CC
cord-022594-fx044gcd	300	21	itching	itching	NN
cord-022594-fx044gcd	300	22	,	,	,
cord-022594-fx044gcd	300	23	and	and	CC
cord-022594-fx044gcd	300	24	sharp	sharp	JJ
cord-022594-fx044gcd	300	25	neuralgic	neuralgic	JJ
cord-022594-fx044gcd	300	26	pain	pain	NN
cord-022594-fx044gcd	300	27	is	be	VBZ
cord-022594-fx044gcd	300	28	common	common	JJ
cord-022594-fx044gcd	300	29	.	.	.
cord-022594-fx044gcd	301	1	Trigeminal	trigeminal	JJ
cord-022594-fx044gcd	301	2	neuralgia	neuralgia	NN
cord-022594-fx044gcd	301	3	may	may	MD
cord-022594-fx044gcd	301	4	appear	appear	VB
cord-022594-fx044gcd	301	5	in	in	IN
cord-022594-fx044gcd	301	6	patients	patient	NNS
cord-022594-fx044gcd	301	7	with	with	IN
cord-022594-fx044gcd	301	8	MS	MS	NNP
cord-022594-fx044gcd	301	9	(	(	-LRB-
cord-022594-fx044gcd	301	10	Video	Video	NNP
cord-022594-fx044gcd	301	11	106	106	CD
cord-022594-fx044gcd	301	12	,	,	,
cord-022594-fx044gcd	301	13	Trigeminal	Trigeminal	NNP
cord-022594-fx044gcd	301	14	Neuralgia	Neuralgia	NNP
cord-022594-fx044gcd	301	15	)	)	-RRB-
cord-022594-fx044gcd	301	16	.	.	.
cord-022594-fx044gcd	302	1	The	the	DT
cord-022594-fx044gcd	302	2	occurrence	occurrence	NN
cord-022594-fx044gcd	302	3	of	of	IN
cord-022594-fx044gcd	302	4	trigeminal	trigeminal	JJ
cord-022594-fx044gcd	302	5	neuralgia	neuralgia	NN
cord-022594-fx044gcd	302	6	in	in	IN
cord-022594-fx044gcd	302	7	a	a	DT
cord-022594-fx044gcd	302	8	person	person	NN
cord-022594-fx044gcd	302	9	younger	young	JJR
cord-022594-fx044gcd	302	10	than	than	IN
cord-022594-fx044gcd	302	11	age	age	NN
cord-022594-fx044gcd	302	12	40	40	CD
cord-022594-fx044gcd	302	13	is	be	VBZ
cord-022594-fx044gcd	302	14	suggestive	suggestive	JJ
cord-022594-fx044gcd	302	15	of	of	IN
cord-022594-fx044gcd	302	16	MS	MS	NNP
cord-022594-fx044gcd	302	17	.	.	.
cord-022594-fx044gcd	303	1	Lhermitte	Lhermitte	NNP
cord-022594-fx044gcd	303	2	's	's	POS
cord-022594-fx044gcd	303	3	sign	sign	NN
cord-022594-fx044gcd	303	4	(	(	-LRB-
cord-022594-fx044gcd	303	5	transient	transient	JJ
cord-022594-fx044gcd	303	6	sensory	sensory	JJ
cord-022594-fx044gcd	303	7	symptoms	symptom	NNS
cord-022594-fx044gcd	303	8	usually	usually	RB
cord-022594-fx044gcd	303	9	precipitated	precipitate	VBN
cord-022594-fx044gcd	303	10	by	by	IN
cord-022594-fx044gcd	303	11	neck	neck	NN
cord-022594-fx044gcd	303	12	flexion	flexion	NN
cord-022594-fx044gcd	303	13	)	)	-RRB-
cord-022594-fx044gcd	303	14	is	be	VBZ
cord-022594-fx044gcd	303	15	usually	usually	RB
cord-022594-fx044gcd	303	16	described	describe	VBN
cord-022594-fx044gcd	303	17	as	as	IN
cord-022594-fx044gcd	303	18	an	an	DT
cord-022594-fx044gcd	303	19	electrical	electrical	JJ
cord-022594-fx044gcd	303	20	or	or	CC
cord-022594-fx044gcd	303	21	tingling	tingling	JJ
cord-022594-fx044gcd	303	22	sensation	sensation	NN
cord-022594-fx044gcd	303	23	that	that	WDT
cord-022594-fx044gcd	303	24	travels	travel	VBZ
cord-022594-fx044gcd	303	25	down	down	IN
cord-022594-fx044gcd	303	26	the	the	DT
cord-022594-fx044gcd	303	27	spine	spine	NN
cord-022594-fx044gcd	303	28	or	or	CC
cord-022594-fx044gcd	303	29	into	into	IN
cord-022594-fx044gcd	303	30	the	the	DT
cord-022594-fx044gcd	303	31	extremities	extremity	NNS
cord-022594-fx044gcd	303	32	.	.	.
cord-022594-fx044gcd	304	1	Although	although	IN
cord-022594-fx044gcd	304	2	quite	quite	RB
cord-022594-fx044gcd	304	3	common	common	JJ
cord-022594-fx044gcd	304	4	in	in	IN
cord-022594-fx044gcd	304	5	MS	MS	NNP
cord-022594-fx044gcd	304	6	,	,	,
cord-022594-fx044gcd	304	7	Lhermitte	Lhermitte	NNP
cord-022594-fx044gcd	304	8	's	's	POS
cord-022594-fx044gcd	304	9	sign	sign	NN
cord-022594-fx044gcd	304	10	can	can	MD
cord-022594-fx044gcd	304	11	also	also	RB
cord-022594-fx044gcd	304	12	occur	occur	VB
cord-022594-fx044gcd	304	13	with	with	IN
cord-022594-fx044gcd	304	14	a	a	DT
cord-022594-fx044gcd	304	15	wide	wide	JJ
cord-022594-fx044gcd	304	16	variety	variety	NN
cord-022594-fx044gcd	304	17	of	of	IN
cord-022594-fx044gcd	304	18	other	other	JJ
cord-022594-fx044gcd	304	19	disorders	disorder	NNS
cord-022594-fx044gcd	304	20	,	,	,
cord-022594-fx044gcd	304	21	such	such	JJ
cord-022594-fx044gcd	304	22	as	as	IN
cord-022594-fx044gcd	304	23	vitamin	vitamin	NN
cord-022594-fx044gcd	304	24	B	b	NN
cord-022594-fx044gcd	304	25	12	12	CD
cord-022594-fx044gcd	304	26	deficiency	deficiency	NN
cord-022594-fx044gcd	304	27	,	,	,
cord-022594-fx044gcd	304	28	spondylosis	spondylosis	NN
cord-022594-fx044gcd	304	29	,	,	,
cord-022594-fx044gcd	304	30	Chiari	Chiari	NNP
cord-022594-fx044gcd	304	31	malformation	malformation	NN
cord-022594-fx044gcd	304	32	,	,	,
cord-022594-fx044gcd	304	33	and	and	CC
cord-022594-fx044gcd	304	34	tumors	tumor	NNS
cord-022594-fx044gcd	304	35	,	,	,
cord-022594-fx044gcd	304	36	and	and	CC
cord-022594-fx044gcd	304	37	after	after	IN
cord-022594-fx044gcd	304	38	cisplatin	cisplatin	NN
cord-022594-fx044gcd	304	39	chemotherapy	chemotherapy	NN
cord-022594-fx044gcd	304	40	.	.	.
cord-022594-fx044gcd	305	1	Several	several	JJ
cord-022594-fx044gcd	305	2	other	other	JJ
cord-022594-fx044gcd	305	3	paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	305	4	symptoms	symptom	NNS
cord-022594-fx044gcd	305	5	are	be	VBP
cord-022594-fx044gcd	305	6	occasionally	occasionally	RB
cord-022594-fx044gcd	305	7	encountered	encounter	VBN
cord-022594-fx044gcd	305	8	,	,	,
cord-022594-fx044gcd	305	9	including	include	VBG
cord-022594-fx044gcd	305	10	paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	305	11	dysarthria	dysarthria	NN
cord-022594-fx044gcd	305	12	and	and	CC
cord-022594-fx044gcd	305	13	ataxia	ataxia	NN
cord-022594-fx044gcd	305	14	,	,	,
cord-022594-fx044gcd	305	15	paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	305	16	diplopia	diplopia	NN
cord-022594-fx044gcd	305	17	,	,	,
cord-022594-fx044gcd	305	18	and	and	CC
cord-022594-fx044gcd	305	19	combinations	combination	NNS
cord-022594-fx044gcd	305	20	of	of	IN
cord-022594-fx044gcd	305	21	these	these	DT
cord-022594-fx044gcd	305	22	symptoms	symptom	NNS
cord-022594-fx044gcd	305	23	.	.	.
cord-022594-fx044gcd	306	1	Facial	facial	JJ
cord-022594-fx044gcd	306	2	myokymia	myokymia	NN
cord-022594-fx044gcd	306	3	and	and	CC
cord-022594-fx044gcd	306	4	hemifacial	hemifacial	JJ
cord-022594-fx044gcd	306	5	spasm	spasm	NN
cord-022594-fx044gcd	306	6	are	be	VBP
cord-022594-fx044gcd	306	7	additional	additional	JJ
cord-022594-fx044gcd	306	8	transient	transient	JJ
cord-022594-fx044gcd	306	9	(	(	-LRB-
cord-022594-fx044gcd	306	10	lasting	lasting	JJ
cord-022594-fx044gcd	306	11	months	month	NNS
cord-022594-fx044gcd	306	12	)	)	-RRB-
cord-022594-fx044gcd	306	13	phenomena	phenomena	VBN
cord-022594-fx044gcd	306	14	sometimes	sometimes	RB
cord-022594-fx044gcd	306	15	due	due	JJ
cord-022594-fx044gcd	306	16	to	to	IN
cord-022594-fx044gcd	306	17	brain	brain	NN
cord-022594-fx044gcd	306	18	stem	stem	NN
cord-022594-fx044gcd	306	19	demyelination	demyelination	NN
cord-022594-fx044gcd	306	20	(	(	-LRB-
cord-022594-fx044gcd	306	21	Video	Video	NNP
cord-022594-fx044gcd	306	22	110	110	CD
cord-022594-fx044gcd	306	23	,	,	,
cord-022594-fx044gcd	306	24	Facial	Facial	NNP
cord-022594-fx044gcd	306	25	Myokymia	Myokymia	NNP
cord-022594-fx044gcd	306	26	;	;	:
cord-022594-fx044gcd	306	27	Video	Video	NNP
cord-022594-fx044gcd	306	28	224	224	CD
cord-022594-fx044gcd	306	29	,	,	,
cord-022594-fx044gcd	306	30	Hemifacial	Hemifacial	NNP
cord-022594-fx044gcd	306	31	Spasm	Spasm	NNP
cord-022594-fx044gcd	306	32	)	)	-RRB-
cord-022594-fx044gcd	306	33	.	.	.
cord-022594-fx044gcd	307	1	Trismus	Trismus	NNP
cord-022594-fx044gcd	307	2	,	,	,
cord-022594-fx044gcd	307	3	kinesigenic	kinesigenic	NNP
cord-022594-fx044gcd	307	4	dystonia	dystonia	NNP
cord-022594-fx044gcd	307	5	,	,	,
cord-022594-fx044gcd	307	6	paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	307	7	kinesigenic	kinesigenic	NNP
cord-022594-fx044gcd	307	8	choreoathetosis	choreoathetosis	NN
cord-022594-fx044gcd	307	9	,	,	,
cord-022594-fx044gcd	307	10	and	and	CC
cord-022594-fx044gcd	307	11	segmental	segmental	JJ
cord-022594-fx044gcd	307	12	myoclonus	myoclonus	NN
cord-022594-fx044gcd	307	13	have	have	VBP
cord-022594-fx044gcd	307	14	also	also	RB
cord-022594-fx044gcd	307	15	been	be	VBN
cord-022594-fx044gcd	307	16	described	describe	VBN
cord-022594-fx044gcd	307	17	in	in	IN
cord-022594-fx044gcd	307	18	case	case	NN
cord-022594-fx044gcd	307	19	reports	report	NNS
cord-022594-fx044gcd	307	20	of	of	IN
cord-022594-fx044gcd	307	21	MS	MS	NNP
cord-022594-fx044gcd	307	22	patients	patient	NNS
cord-022594-fx044gcd	307	23	as	as	IN
cord-022594-fx044gcd	307	24	rare	rare	JJ
cord-022594-fx044gcd	307	25	and	and	CC
cord-022594-fx044gcd	307	26	unusual	unusual	JJ
cord-022594-fx044gcd	307	27	examination	examination	NN
cord-022594-fx044gcd	307	28	findings	finding	NNS
cord-022594-fx044gcd	307	29	.	.	.
cord-022594-fx044gcd	308	1	Seizures	seizure	NNS
cord-022594-fx044gcd	308	2	occur	occur	VBP
cord-022594-fx044gcd	308	3	in	in	IN
cord-022594-fx044gcd	308	4	a	a	DT
cord-022594-fx044gcd	308	5	larger	large	JJR
cord-022594-fx044gcd	308	6	proportion	proportion	NN
cord-022594-fx044gcd	308	7	of	of	IN
cord-022594-fx044gcd	308	8	MS	MS	NNP
cord-022594-fx044gcd	308	9	cases	case	NNS
cord-022594-fx044gcd	308	10	compared	compare	VBN
cord-022594-fx044gcd	308	11	to	to	IN
cord-022594-fx044gcd	308	12	normal	normal	JJ
cord-022594-fx044gcd	308	13	control	control	NN
cord-022594-fx044gcd	308	14	subjects	subject	NNS
cord-022594-fx044gcd	308	15	.	.	.
cord-022594-fx044gcd	309	1	A	a	DT
cord-022594-fx044gcd	309	2	recently	recently	RB
cord-022594-fx044gcd	309	3	published	publish	VBN
cord-022594-fx044gcd	309	4	review	review	NN
cord-022594-fx044gcd	309	5	of	of	IN
cord-022594-fx044gcd	309	6	29	29	CD
cord-022594-fx044gcd	309	7	case	case	NN
cord-022594-fx044gcd	309	8	series	series	NN
cord-022594-fx044gcd	309	9	of	of	IN
cord-022594-fx044gcd	309	10	MS	MS	NNP
cord-022594-fx044gcd	309	11	patients	patient	NNS
cord-022594-fx044gcd	309	12	with	with	IN
cord-022594-fx044gcd	309	13	epileptic	epileptic	JJ
cord-022594-fx044gcd	309	14	seizures	seizure	NNS
cord-022594-fx044gcd	309	15	yielded	yield	VBD
cord-022594-fx044gcd	309	16	a	a	DT
cord-022594-fx044gcd	309	17	prevalence	prevalence	NN
cord-022594-fx044gcd	309	18	of	of	IN
cord-022594-fx044gcd	309	19	2.3	2.3	CD
cord-022594-fx044gcd	309	20	%	%	NN
cord-022594-fx044gcd	309	21	.	.	.
cord-022594-fx044gcd	310	1	33	33	CD
cord-022594-fx044gcd	311	1	This	this	DT
cord-022594-fx044gcd	311	2	represents	represent	VBZ
cord-022594-fx044gcd	311	3	an	an	DT
cord-022594-fx044gcd	311	4	approximately	approximately	RB
cord-022594-fx044gcd	311	5	three	three	CD
cord-022594-fx044gcd	311	6	-	-	HYPH
cord-022594-fx044gcd	311	7	to	to	TO
cord-022594-fx044gcd	311	8	sixfold	sixfold	JJ
cord-022594-fx044gcd	311	9	increase	increase	NN
cord-022594-fx044gcd	311	10	compared	compare	VBN
cord-022594-fx044gcd	311	11	to	to	IN
cord-022594-fx044gcd	311	12	the	the	DT
cord-022594-fx044gcd	311	13	general	general	JJ
cord-022594-fx044gcd	311	14	adult	adult	NN
cord-022594-fx044gcd	311	15	population	population	NN
cord-022594-fx044gcd	311	16	.	.	.
cord-022594-fx044gcd	312	1	Cortical	cortical	JJ
cord-022594-fx044gcd	312	2	and	and	CC
cord-022594-fx044gcd	312	3	juxtacortical	juxtacortical	JJ
cord-022594-fx044gcd	312	4	lesions	lesion	NNS
cord-022594-fx044gcd	312	5	may	may	MD
cord-022594-fx044gcd	312	6	be	be	VB
cord-022594-fx044gcd	312	7	responsible	responsible	JJ
cord-022594-fx044gcd	312	8	for	for	IN
cord-022594-fx044gcd	312	9	the	the	DT
cord-022594-fx044gcd	312	10	increased	increase	VBN
cord-022594-fx044gcd	312	11	incidence	incidence	NN
cord-022594-fx044gcd	312	12	of	of	IN
cord-022594-fx044gcd	312	13	seizures	seizure	NNS
cord-022594-fx044gcd	312	14	in	in	IN
cord-022594-fx044gcd	312	15	MS	MS	NNP
cord-022594-fx044gcd	312	16	patients	patient	NNS
cord-022594-fx044gcd	312	17	.	.	.
cord-022594-fx044gcd	313	1	However	however	RB
cord-022594-fx044gcd	313	2	,	,	,
cord-022594-fx044gcd	313	3	such	such	JJ
cord-022594-fx044gcd	313	4	plaques	plaque	NNS
cord-022594-fx044gcd	313	5	are	be	VBP
cord-022594-fx044gcd	313	6	common	common	JJ
cord-022594-fx044gcd	313	7	and	and	CC
cord-022594-fx044gcd	313	8	seizures	seizure	NNS
cord-022594-fx044gcd	313	9	in	in	IN
cord-022594-fx044gcd	313	10	MS	MS	NNP
cord-022594-fx044gcd	313	11	are	be	VBP
cord-022594-fx044gcd	313	12	not	not	RB
cord-022594-fx044gcd	313	13	,	,	,
cord-022594-fx044gcd	313	14	which	which	WDT
cord-022594-fx044gcd	313	15	suggests	suggest	VBZ
cord-022594-fx044gcd	313	16	that	that	IN
cord-022594-fx044gcd	313	17	other	other	JJ
cord-022594-fx044gcd	313	18	factors	factor	NNS
cord-022594-fx044gcd	313	19	may	may	MD
cord-022594-fx044gcd	313	20	also	also	RB
cord-022594-fx044gcd	313	21	contribute	contribute	VB
cord-022594-fx044gcd	313	22	to	to	IN
cord-022594-fx044gcd	313	23	the	the	DT
cord-022594-fx044gcd	313	24	relationship	relationship	NN
cord-022594-fx044gcd	313	25	between	between	IN
cord-022594-fx044gcd	313	26	epilepsy	epilepsy	NN
cord-022594-fx044gcd	313	27	and	and	CC
cord-022594-fx044gcd	313	28	MS	MS	NNP
cord-022594-fx044gcd	313	29	.	.	.
cord-022594-fx044gcd	314	1	Focal	focal	JJ
cord-022594-fx044gcd	314	2	motor	motor	NN
cord-022594-fx044gcd	314	3	seizures	seizure	NNS
cord-022594-fx044gcd	314	4	,	,	,
cord-022594-fx044gcd	314	5	possibly	possibly	RB
cord-022594-fx044gcd	314	6	with	with	IN
cord-022594-fx044gcd	314	7	secondary	secondary	JJ
cord-022594-fx044gcd	314	8	generalization	generalization	NN
cord-022594-fx044gcd	314	9	,	,	,
cord-022594-fx044gcd	314	10	are	be	VBP
cord-022594-fx044gcd	314	11	the	the	DT
cord-022594-fx044gcd	314	12	most	most	RBS
cord-022594-fx044gcd	314	13	frequent	frequent	JJ
cord-022594-fx044gcd	314	14	.	.	.
cord-022594-fx044gcd	315	1	The	the	DT
cord-022594-fx044gcd	315	2	occurrence	occurrence	NN
cord-022594-fx044gcd	315	3	of	of	IN
cord-022594-fx044gcd	315	4	seizures	seizure	NNS
cord-022594-fx044gcd	315	5	usually	usually	RB
cord-022594-fx044gcd	315	6	follows	follow	VBZ
cord-022594-fx044gcd	315	7	one	one	CD
cord-022594-fx044gcd	315	8	of	of	IN
cord-022594-fx044gcd	315	9	two	two	CD
cord-022594-fx044gcd	315	10	patterns	pattern	NNS
cord-022594-fx044gcd	315	11	.	.	.
cord-022594-fx044gcd	316	1	On	on	IN
cord-022594-fx044gcd	316	2	occasion	occasion	NN
cord-022594-fx044gcd	316	3	,	,	,
cord-022594-fx044gcd	316	4	focal	focal	JJ
cord-022594-fx044gcd	316	5	onset	onset	NN
cord-022594-fx044gcd	316	6	seizures	seizure	NNS
cord-022594-fx044gcd	316	7	begin	begin	VBP
cord-022594-fx044gcd	316	8	early	early	RB
cord-022594-fx044gcd	316	9	in	in	IN
cord-022594-fx044gcd	316	10	the	the	DT
cord-022594-fx044gcd	316	11	course	course	NN
cord-022594-fx044gcd	316	12	of	of	IN
cord-022594-fx044gcd	316	13	MS	MS	NNP
cord-022594-fx044gcd	316	14	and	and	CC
cord-022594-fx044gcd	316	15	later	later	RB
cord-022594-fx044gcd	316	16	remit	remit	VB
cord-022594-fx044gcd	316	17	.	.	.
cord-022594-fx044gcd	317	1	The	the	DT
cord-022594-fx044gcd	317	2	start	start	NN
cord-022594-fx044gcd	317	3	of	of	IN
cord-022594-fx044gcd	317	4	seizures	seizure	NNS
cord-022594-fx044gcd	317	5	late	late	RB
cord-022594-fx044gcd	317	6	in	in	IN
cord-022594-fx044gcd	317	7	the	the	DT
cord-022594-fx044gcd	317	8	course	course	NN
cord-022594-fx044gcd	317	9	of	of	IN
cord-022594-fx044gcd	317	10	MS	MS	NNP
cord-022594-fx044gcd	317	11	more	more	RBR
cord-022594-fx044gcd	317	12	often	often	RB
cord-022594-fx044gcd	317	13	poses	pose	VBZ
cord-022594-fx044gcd	317	14	a	a	DT
cord-022594-fx044gcd	317	15	chronic	chronic	JJ
cord-022594-fx044gcd	317	16	problem	problem	NN
cord-022594-fx044gcd	317	17	and	and	CC
cord-022594-fx044gcd	317	18	may	may	MD
cord-022594-fx044gcd	317	19	be	be	VB
cord-022594-fx044gcd	317	20	difficult	difficult	JJ
cord-022594-fx044gcd	317	21	to	to	TO
cord-022594-fx044gcd	317	22	control	control	VB
cord-022594-fx044gcd	317	23	.	.	.
cord-022594-fx044gcd	318	1	The	the	DT
cord-022594-fx044gcd	318	2	eye	eye	NN
cord-022594-fx044gcd	318	3	is	be	VBZ
cord-022594-fx044gcd	318	4	the	the	DT
cord-022594-fx044gcd	318	5	only	only	JJ
cord-022594-fx044gcd	318	6	organ	organ	NN
cord-022594-fx044gcd	318	7	outside	outside	IN
cord-022594-fx044gcd	318	8	the	the	DT
cord-022594-fx044gcd	318	9	nervous	nervous	JJ
cord-022594-fx044gcd	318	10	system	system	NN
cord-022594-fx044gcd	318	11	that	that	WDT
cord-022594-fx044gcd	318	12	is	be	VBZ
cord-022594-fx044gcd	318	13	sometimes	sometimes	RB
cord-022594-fx044gcd	318	14	involved	involve	VBN
cord-022594-fx044gcd	318	15	in	in	IN
cord-022594-fx044gcd	318	16	MS	MS	NNP
cord-022594-fx044gcd	318	17	.	.	.
cord-022594-fx044gcd	319	1	Uveitis	Uveitis	NNP
cord-022594-fx044gcd	319	2	and	and	CC
cord-022594-fx044gcd	319	3	retinal	retinal	JJ
cord-022594-fx044gcd	319	4	periphlebitis	periphlebitis	RB
cord-022594-fx044gcd	319	5	each	each	DT
cord-022594-fx044gcd	319	6	occur	occur	VBP
cord-022594-fx044gcd	319	7	in	in	IN
cord-022594-fx044gcd	319	8	at	at	RB
cord-022594-fx044gcd	319	9	least	least	RBS
cord-022594-fx044gcd	319	10	10	10	CD
cord-022594-fx044gcd	319	11	%	%	NN
cord-022594-fx044gcd	319	12	of	of	IN
cord-022594-fx044gcd	319	13	MS	MS	NNP
cord-022594-fx044gcd	319	14	patients	patient	NNS
cord-022594-fx044gcd	319	15	.	.	.
cord-022594-fx044gcd	320	1	In	in	IN
cord-022594-fx044gcd	320	2	a	a	DT
cord-022594-fx044gcd	320	3	recent	recent	JJ
cord-022594-fx044gcd	320	4	study	study	NN
cord-022594-fx044gcd	320	5	,	,	,
cord-022594-fx044gcd	320	6	most	most	JJS
cord-022594-fx044gcd	320	7	patients	patient	NNS
cord-022594-fx044gcd	320	8	with	with	IN
cord-022594-fx044gcd	320	9	MS	MS	NNP
cord-022594-fx044gcd	320	10	-	-	HYPH
cord-022594-fx044gcd	320	11	associated	associate	VBN
cord-022594-fx044gcd	320	12	uveitis	uveitis	NN
cord-022594-fx044gcd	320	13	were	be	VBD
cord-022594-fx044gcd	320	14	white	white	JJ
cord-022594-fx044gcd	320	15	females	female	NNS
cord-022594-fx044gcd	320	16	between	between	IN
cord-022594-fx044gcd	320	17	20	20	CD
cord-022594-fx044gcd	320	18	and	and	CC
cord-022594-fx044gcd	320	19	50	50	CD
cord-022594-fx044gcd	320	20	years	year	NNS
cord-022594-fx044gcd	320	21	of	of	IN
cord-022594-fx044gcd	320	22	age	age	NN
cord-022594-fx044gcd	320	23	.	.	.
cord-022594-fx044gcd	321	1	34	34	CD
cord-022594-fx044gcd	322	1	The	the	DT
cord-022594-fx044gcd	322	2	diagnosis	diagnosis	NN
cord-022594-fx044gcd	322	3	of	of	IN
cord-022594-fx044gcd	322	4	MS	MS	NNP
cord-022594-fx044gcd	322	5	preceded	precede	VBD
cord-022594-fx044gcd	322	6	the	the	DT
cord-022594-fx044gcd	322	7	onset	onset	NN
cord-022594-fx044gcd	322	8	of	of	IN
cord-022594-fx044gcd	322	9	uveitis	uveitis	NN
cord-022594-fx044gcd	322	10	in	in	IN
cord-022594-fx044gcd	322	11	56	56	CD
cord-022594-fx044gcd	322	12	%	%	NN
cord-022594-fx044gcd	322	13	,	,	,
cord-022594-fx044gcd	322	14	followed	follow	VBD
cord-022594-fx044gcd	322	15	it	-PRON-	PRP
cord-022594-fx044gcd	322	16	in	in	IN
cord-022594-fx044gcd	322	17	25	25	CD
cord-022594-fx044gcd	322	18	%	%	NN
cord-022594-fx044gcd	322	19	.	.	.
cord-022594-fx044gcd	323	1	In	in	IN
cord-022594-fx044gcd	323	2	over	over	IN
cord-022594-fx044gcd	323	3	90	90	CD
cord-022594-fx044gcd	323	4	%	%	NN
cord-022594-fx044gcd	323	5	of	of	IN
cord-022594-fx044gcd	323	6	the	the	DT
cord-022594-fx044gcd	323	7	cases	case	NNS
cord-022594-fx044gcd	323	8	,	,	,
cord-022594-fx044gcd	323	9	the	the	DT
cord-022594-fx044gcd	323	10	uveitis	uveitis	NN
cord-022594-fx044gcd	323	11	was	be	VBD
cord-022594-fx044gcd	323	12	bilateral	bilateral	JJ
cord-022594-fx044gcd	323	13	.	.	.
cord-022594-fx044gcd	324	1	Pars	Pars	NNP
cord-022594-fx044gcd	324	2	planitis	planitis	NNP
cord-022594-fx044gcd	324	3	was	be	VBD
cord-022594-fx044gcd	324	4	found	find	VBN
cord-022594-fx044gcd	324	5	to	to	TO
cord-022594-fx044gcd	324	6	be	be	VB
cord-022594-fx044gcd	324	7	the	the	DT
cord-022594-fx044gcd	324	8	most	most	RBS
cord-022594-fx044gcd	324	9	frequent	frequent	JJ
cord-022594-fx044gcd	324	10	form	form	NN
cord-022594-fx044gcd	324	11	of	of	IN
cord-022594-fx044gcd	324	12	uveitis	uveitis	NN
cord-022594-fx044gcd	324	13	(	(	-LRB-
cord-022594-fx044gcd	324	14	over	over	IN
cord-022594-fx044gcd	324	15	80	80	CD
cord-022594-fx044gcd	324	16	%	%	NN
cord-022594-fx044gcd	324	17	)	)	-RRB-
cord-022594-fx044gcd	324	18	,	,	,
cord-022594-fx044gcd	324	19	and	and	CC
cord-022594-fx044gcd	324	20	concomitant	concomitant	JJ
cord-022594-fx044gcd	324	21	anterior	anterior	JJ
cord-022594-fx044gcd	324	22	chamber	chamber	NN
cord-022594-fx044gcd	324	23	inflammation	inflammation	NN
cord-022594-fx044gcd	324	24	was	be	VBD
cord-022594-fx044gcd	324	25	also	also	RB
cord-022594-fx044gcd	324	26	common	common	JJ
cord-022594-fx044gcd	324	27	.	.	.
cord-022594-fx044gcd	325	1	Usually	usually	RB
cord-022594-fx044gcd	325	2	MS	MS	NNP
cord-022594-fx044gcd	325	3	-	-	HYPH
cord-022594-fx044gcd	325	4	associated	associate	VBN
cord-022594-fx044gcd	325	5	uveitis	uveitis	NN
cord-022594-fx044gcd	325	6	is	be	VBZ
cord-022594-fx044gcd	325	7	benign	benign	JJ
cord-022594-fx044gcd	325	8	from	from	IN
cord-022594-fx044gcd	325	9	the	the	DT
cord-022594-fx044gcd	325	10	standpoint	standpoint	NN
cord-022594-fx044gcd	325	11	of	of	IN
cord-022594-fx044gcd	325	12	visual	visual	JJ
cord-022594-fx044gcd	325	13	acuity	acuity	NN
cord-022594-fx044gcd	325	14	.	.	.
cord-022594-fx044gcd	326	1	Uveitis	Uveitis	NNP
cord-022594-fx044gcd	326	2	can	can	MD
cord-022594-fx044gcd	326	3	involve	involve	VB
cord-022594-fx044gcd	326	4	the	the	DT
cord-022594-fx044gcd	326	5	posterior	posterior	JJ
cord-022594-fx044gcd	326	6	,	,	,
cord-022594-fx044gcd	326	7	intermediate	intermediate	JJ
cord-022594-fx044gcd	326	8	(	(	-LRB-
cord-022594-fx044gcd	326	9	pars	pars	NNP
cord-022594-fx044gcd	326	10	planitis	planitis	NNP
cord-022594-fx044gcd	326	11	)	)	-RRB-
cord-022594-fx044gcd	326	12	,	,	,
cord-022594-fx044gcd	326	13	or	or	CC
cord-022594-fx044gcd	326	14	rarely	rarely	RB
cord-022594-fx044gcd	326	15	anterior	anterior	JJ
cord-022594-fx044gcd	326	16	portion	portion	NN
cord-022594-fx044gcd	326	17	and	and	CC
cord-022594-fx044gcd	326	18	resembles	resemble	VBZ
cord-022594-fx044gcd	326	19	that	that	DT
cord-022594-fx044gcd	326	20	seen	see	VBN
cord-022594-fx044gcd	326	21	in	in	IN
cord-022594-fx044gcd	326	22	other	other	JJ
cord-022594-fx044gcd	326	23	inflammatory	inflammatory	NN
cord-022594-fx044gcd	326	24	(	(	-LRB-
cord-022594-fx044gcd	326	25	e.g.	e.g.	RB
cord-022594-fx044gcd	326	26	,	,	,
cord-022594-fx044gcd	326	27	sarcoid	sarcoid	NNP
cord-022594-fx044gcd	326	28	,	,	,
cord-022594-fx044gcd	326	29	Reiter	Reiter	NNP
cord-022594-fx044gcd	326	30	's	's	POS
cord-022594-fx044gcd	326	31	syndrome	syndrome	NN
cord-022594-fx044gcd	326	32	,	,	,
cord-022594-fx044gcd	326	33	Behçet	Behçet	NNP
cord-022594-fx044gcd	326	34	's	's	POS
cord-022594-fx044gcd	326	35	syndrome	syndrome	NN
cord-022594-fx044gcd	326	36	,	,	,
cord-022594-fx044gcd	326	37	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	326	38	bowel	bowel	NN
cord-022594-fx044gcd	326	39	disease	disease	NN
cord-022594-fx044gcd	326	40	,	,	,
cord-022594-fx044gcd	326	41	systemic	systemic	JJ
cord-022594-fx044gcd	326	42	lupus	lupus	NN
cord-022594-fx044gcd	326	43	erythematosus	erythematosus	NN
cord-022594-fx044gcd	326	44	)	)	-RRB-
cord-022594-fx044gcd	326	45	and	and	CC
cord-022594-fx044gcd	326	46	infectious	infectious	JJ
cord-022594-fx044gcd	326	47	(	(	-LRB-
cord-022594-fx044gcd	326	48	e.g.	e.g.	RB
cord-022594-fx044gcd	326	49	,	,	,
cord-022594-fx044gcd	326	50	syphilis	syphili	NNS
cord-022594-fx044gcd	326	51	,	,	,
cord-022594-fx044gcd	326	52	tuberculosis	tuberculosis	NN
cord-022594-fx044gcd	326	53	,	,	,
cord-022594-fx044gcd	326	54	Lyme	Lyme	NNP
cord-022594-fx044gcd	326	55	disease	disease	NN
cord-022594-fx044gcd	326	56	)	)	-RRB-
cord-022594-fx044gcd	326	57	conditions	condition	NNS
cord-022594-fx044gcd	326	58	.	.	.
cord-022594-fx044gcd	327	1	Periphlebitis	Periphlebitis	NNP
cord-022594-fx044gcd	327	2	is	be	VBZ
cord-022594-fx044gcd	327	3	seen	see	VBN
cord-022594-fx044gcd	327	4	as	as	IN
cord-022594-fx044gcd	327	5	venous	venous	JJ
cord-022594-fx044gcd	327	6	sheathing	sheathing	NN
cord-022594-fx044gcd	327	7	on	on	IN
cord-022594-fx044gcd	327	8	funduscopic	funduscopic	NNP
cord-022594-fx044gcd	327	9	examination	examination	NN
cord-022594-fx044gcd	327	10	and	and	CC
cord-022594-fx044gcd	327	11	is	be	VBZ
cord-022594-fx044gcd	327	12	histologically	histologically	RB
cord-022594-fx044gcd	327	13	identical	identical	JJ
cord-022594-fx044gcd	327	14	to	to	IN
cord-022594-fx044gcd	327	15	the	the	DT
cord-022594-fx044gcd	327	16	perivascular	perivascular	JJ
cord-022594-fx044gcd	327	17	inflammation	inflammation	NN
cord-022594-fx044gcd	327	18	present	present	JJ
cord-022594-fx044gcd	327	19	in	in	IN
cord-022594-fx044gcd	327	20	brain	brain	NN
cord-022594-fx044gcd	327	21	white	white	JJ
cord-022594-fx044gcd	327	22	matter	matter	NN
cord-022594-fx044gcd	327	23	.	.	.
cord-022594-fx044gcd	328	1	It	-PRON-	PRP
cord-022594-fx044gcd	328	2	is	be	VBZ
cord-022594-fx044gcd	328	3	interesting	interesting	JJ
cord-022594-fx044gcd	328	4	that	that	IN
cord-022594-fx044gcd	328	5	inflammation	inflammation	NN
cord-022594-fx044gcd	328	6	commonly	commonly	RB
cord-022594-fx044gcd	328	7	occurs	occur	VBZ
cord-022594-fx044gcd	328	8	in	in	IN
cord-022594-fx044gcd	328	9	the	the	DT
cord-022594-fx044gcd	328	10	retina	retina	NN
cord-022594-fx044gcd	328	11	,	,	,
cord-022594-fx044gcd	328	12	which	which	WDT
cord-022594-fx044gcd	328	13	has	have	VBZ
cord-022594-fx044gcd	328	14	a	a	DT
cord-022594-fx044gcd	328	15	peripheral	peripheral	JJ
cord-022594-fx044gcd	328	16	type	type	NN
cord-022594-fx044gcd	328	17	of	of	IN
cord-022594-fx044gcd	328	18	myelin	myelin	NN
cord-022594-fx044gcd	328	19	produced	produce	VBN
cord-022594-fx044gcd	328	20	by	by	IN
cord-022594-fx044gcd	328	21	Schwann	Schwann	NNP
cord-022594-fx044gcd	328	22	cells	cell	NNS
cord-022594-fx044gcd	328	23	.	.	.
cord-022594-fx044gcd	329	1	There	there	EX
cord-022594-fx044gcd	329	2	are	be	VBP
cord-022594-fx044gcd	329	3	occasional	occasional	JJ
cord-022594-fx044gcd	329	4	reports	report	NNS
cord-022594-fx044gcd	329	5	of	of	IN
cord-022594-fx044gcd	329	6	peripheral	peripheral	JJ
cord-022594-fx044gcd	329	7	nerve	nerve	NN
cord-022594-fx044gcd	329	8	or	or	CC
cord-022594-fx044gcd	329	9	nerve	nerve	NN
cord-022594-fx044gcd	329	10	root	root	NN
cord-022594-fx044gcd	329	11	demyelination	demyelination	NN
cord-022594-fx044gcd	329	12	in	in	IN
cord-022594-fx044gcd	329	13	MS	MS	NNP
cord-022594-fx044gcd	329	14	patients	patient	NNS
cord-022594-fx044gcd	329	15	as	as	RB
cord-022594-fx044gcd	329	16	well	well	RB
cord-022594-fx044gcd	329	17	as	as	IN
cord-022594-fx044gcd	329	18	central	central	JJ
cord-022594-fx044gcd	329	19	demyelination	demyelination	NN
cord-022594-fx044gcd	329	20	in	in	IN
cord-022594-fx044gcd	329	21	acute	acute	JJ
cord-022594-fx044gcd	329	22	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	329	23	demyelinating	demyelinating	NN
cord-022594-fx044gcd	329	24	polyradiculoneuropathy	polyradiculoneuropathy	NN
cord-022594-fx044gcd	329	25	and	and	CC
cord-022594-fx044gcd	329	26	chronic	chronic	JJ
cord-022594-fx044gcd	329	27	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	329	28	demyelinating	demyelinating	NN
cord-022594-fx044gcd	329	29	polyradiculoneuropathy	polyradiculoneuropathy	NN
cord-022594-fx044gcd	329	30	(	(	-LRB-
cord-022594-fx044gcd	329	31	see	see	VB
cord-022594-fx044gcd	329	32	Chapter	chapter	NN
cord-022594-fx044gcd	329	33	49	49	CD
cord-022594-fx044gcd	329	34	)	)	-RRB-
cord-022594-fx044gcd	329	35	.	.	.
cord-022594-fx044gcd	330	1	Some	some	DT
cord-022594-fx044gcd	330	2	of	of	IN
cord-022594-fx044gcd	330	3	these	these	DT
cord-022594-fx044gcd	330	4	cases	case	NNS
cord-022594-fx044gcd	330	5	may	may	MD
cord-022594-fx044gcd	330	6	be	be	VB
cord-022594-fx044gcd	330	7	due	due	JJ
cord-022594-fx044gcd	330	8	to	to	IN
cord-022594-fx044gcd	330	9	the	the	DT
cord-022594-fx044gcd	330	10	incidental	incidental	JJ
cord-022594-fx044gcd	330	11	occurrence	occurrence	NN
cord-022594-fx044gcd	330	12	of	of	IN
cord-022594-fx044gcd	330	13	two	two	CD
cord-022594-fx044gcd	330	14	unrelated	unrelated	JJ
cord-022594-fx044gcd	330	15	disease	disease	NN
cord-022594-fx044gcd	330	16	processes	process	NNS
cord-022594-fx044gcd	330	17	.	.	.
cord-022594-fx044gcd	331	1	However	however	RB
cord-022594-fx044gcd	331	2	,	,	,
cord-022594-fx044gcd	331	3	because	because	IN
cord-022594-fx044gcd	331	4	the	the	DT
cord-022594-fx044gcd	331	5	PNS	PNS	NNP
cord-022594-fx044gcd	331	6	and	and	CC
cord-022594-fx044gcd	331	7	CNS	CNS	NNP
cord-022594-fx044gcd	331	8	share	share	VBP
cord-022594-fx044gcd	331	9	many	many	JJ
cord-022594-fx044gcd	331	10	antigens	antigen	NNS
cord-022594-fx044gcd	331	11	,	,	,
cord-022594-fx044gcd	331	12	including	include	VBG
cord-022594-fx044gcd	331	13	MBP	MBP	NNP
cord-022594-fx044gcd	331	14	,	,	,
cord-022594-fx044gcd	331	15	it	-PRON-	PRP
cord-022594-fx044gcd	331	16	is	be	VBZ
cord-022594-fx044gcd	331	17	possible	possible	JJ
cord-022594-fx044gcd	331	18	that	that	IN
cord-022594-fx044gcd	331	19	an	an	DT
cord-022594-fx044gcd	331	20	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	331	21	reaction	reaction	NN
cord-022594-fx044gcd	331	22	or	or	CC
cord-022594-fx044gcd	331	23	a	a	DT
cord-022594-fx044gcd	331	24	viral	viral	JJ
cord-022594-fx044gcd	331	25	infection	infection	NN
cord-022594-fx044gcd	331	26	could	could	MD
cord-022594-fx044gcd	331	27	involve	involve	VB
cord-022594-fx044gcd	331	28	both	both	CC
cord-022594-fx044gcd	331	29	the	the	DT
cord-022594-fx044gcd	331	30	CNS	CNS	NNP
cord-022594-fx044gcd	331	31	and	and	CC
cord-022594-fx044gcd	331	32	PNS	PNS	NNP
cord-022594-fx044gcd	331	33	.	.	.
cord-022594-fx044gcd	332	1	Persons	person	NNS
cord-022594-fx044gcd	332	2	with	with	IN
cord-022594-fx044gcd	332	3	one	one	CD
cord-022594-fx044gcd	332	4	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	332	5	disorder	disorder	NN
cord-022594-fx044gcd	332	6	generally	generally	RB
cord-022594-fx044gcd	332	7	have	have	VBP
cord-022594-fx044gcd	332	8	an	an	DT
cord-022594-fx044gcd	332	9	increased	increase	VBN
cord-022594-fx044gcd	332	10	risk	risk	NN
cord-022594-fx044gcd	332	11	of	of	IN
cord-022594-fx044gcd	332	12	others	other	NNS
cord-022594-fx044gcd	332	13	.	.	.
cord-022594-fx044gcd	333	1	Even	even	RB
cord-022594-fx044gcd	333	2	though	though	IN
cord-022594-fx044gcd	333	3	there	there	EX
cord-022594-fx044gcd	333	4	are	be	VBP
cord-022594-fx044gcd	333	5	several	several	JJ
cord-022594-fx044gcd	333	6	reports	report	NNS
cord-022594-fx044gcd	333	7	of	of	IN
cord-022594-fx044gcd	333	8	systemic	systemic	JJ
cord-022594-fx044gcd	333	9	and	and	CC
cord-022594-fx044gcd	333	10	organ	organ	NN
cord-022594-fx044gcd	333	11	-	-	HYPH
cord-022594-fx044gcd	333	12	specific	specific	JJ
cord-022594-fx044gcd	333	13	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	333	14	diseases	disease	NNS
cord-022594-fx044gcd	333	15	in	in	IN
cord-022594-fx044gcd	333	16	MS	MS	NNP
cord-022594-fx044gcd	333	17	patients	patient	NNS
cord-022594-fx044gcd	333	18	,	,	,
cord-022594-fx044gcd	333	19	population	population	NN
cord-022594-fx044gcd	333	20	-	-	HYPH
cord-022594-fx044gcd	333	21	based	base	VBN
cord-022594-fx044gcd	333	22	studies	study	NNS
cord-022594-fx044gcd	333	23	have	have	VBP
cord-022594-fx044gcd	333	24	not	not	RB
cord-022594-fx044gcd	333	25	confirmed	confirm	VBN
cord-022594-fx044gcd	333	26	any	any	DT
cord-022594-fx044gcd	333	27	increase	increase	NN
cord-022594-fx044gcd	333	28	in	in	IN
cord-022594-fx044gcd	333	29	prevalence	prevalence	NN
cord-022594-fx044gcd	333	30	of	of	IN
cord-022594-fx044gcd	333	31	these	these	DT
cord-022594-fx044gcd	333	32	disorders	disorder	NNS
cord-022594-fx044gcd	333	33	among	among	IN
cord-022594-fx044gcd	333	34	MS	MS	NNP
cord-022594-fx044gcd	333	35	patients	patient	NNS
cord-022594-fx044gcd	333	36	.	.	.
cord-022594-fx044gcd	334	1	35	35	CD
cord-022594-fx044gcd	335	1	In	in	IN
cord-022594-fx044gcd	335	2	fact	fact	NN
cord-022594-fx044gcd	335	3	,	,	,
cord-022594-fx044gcd	335	4	there	there	EX
cord-022594-fx044gcd	335	5	appears	appear	VBZ
cord-022594-fx044gcd	335	6	to	to	TO
cord-022594-fx044gcd	335	7	be	be	VB
cord-022594-fx044gcd	335	8	a	a	DT
cord-022594-fx044gcd	335	9	negative	negative	JJ
cord-022594-fx044gcd	335	10	association	association	NN
cord-022594-fx044gcd	335	11	between	between	IN
cord-022594-fx044gcd	335	12	MS	MS	NNP
cord-022594-fx044gcd	335	13	and	and	CC
cord-022594-fx044gcd	335	14	rheumatoid	rheumatoid	NN
cord-022594-fx044gcd	335	15	arthritis	arthritis	NN
cord-022594-fx044gcd	335	16	.	.	.
cord-022594-fx044gcd	336	1	Multifocal	multifocal	JJ
cord-022594-fx044gcd	336	2	CNS	CNS	NNP
cord-022594-fx044gcd	336	3	involvement	involvement	NN
cord-022594-fx044gcd	336	4	and	and	CC
cord-022594-fx044gcd	336	5	acute	acute	JJ
cord-022594-fx044gcd	336	6	relapses	relapse	NNS
cord-022594-fx044gcd	336	7	,	,	,
cord-022594-fx044gcd	336	8	remissions	remission	NNS
cord-022594-fx044gcd	336	9	,	,	,
cord-022594-fx044gcd	336	10	and	and	CC
cord-022594-fx044gcd	336	11	slow	slow	JJ
cord-022594-fx044gcd	336	12	progression	progression	NN
cord-022594-fx044gcd	336	13	of	of	IN
cord-022594-fx044gcd	336	14	neurological	neurological	JJ
cord-022594-fx044gcd	336	15	deficits	deficit	NNS
cord-022594-fx044gcd	336	16	typify	typify	VBP
cord-022594-fx044gcd	336	17	MS	MS	NNP
cord-022594-fx044gcd	336	18	.	.	.
cord-022594-fx044gcd	337	1	A	a	DT
cord-022594-fx044gcd	337	2	single	single	JJ
cord-022594-fx044gcd	337	3	episode	episode	NN
cord-022594-fx044gcd	337	4	of	of	IN
cord-022594-fx044gcd	337	5	neurological	neurological	JJ
cord-022594-fx044gcd	337	6	dysfunction	dysfunction	NN
cord-022594-fx044gcd	337	7	can	can	MD
cord-022594-fx044gcd	337	8	be	be	VB
cord-022594-fx044gcd	337	9	suggestive	suggestive	JJ
cord-022594-fx044gcd	337	10	of	of	IN
cord-022594-fx044gcd	337	11	MS	MS	NNP
cord-022594-fx044gcd	337	12	if	if	IN
cord-022594-fx044gcd	337	13	it	-PRON-	PRP
cord-022594-fx044gcd	337	14	follows	follow	VBZ
cord-022594-fx044gcd	337	15	the	the	DT
cord-022594-fx044gcd	337	16	typical	typical	JJ
cord-022594-fx044gcd	337	17	time	time	NN
cord-022594-fx044gcd	337	18	course	course	NN
cord-022594-fx044gcd	337	19	of	of	IN
cord-022594-fx044gcd	337	20	a	a	DT
cord-022594-fx044gcd	337	21	relapse	relapse	NN
cord-022594-fx044gcd	337	22	:	:	:
cord-022594-fx044gcd	337	23	progression	progression	NN
cord-022594-fx044gcd	337	24	over	over	IN
cord-022594-fx044gcd	337	25	less	less	JJR
cord-022594-fx044gcd	337	26	than	than	IN
cord-022594-fx044gcd	337	27	2	2	CD
cord-022594-fx044gcd	337	28	weeks	week	NNS
cord-022594-fx044gcd	337	29	(	(	-LRB-
cord-022594-fx044gcd	337	30	usually	usually	RB
cord-022594-fx044gcd	337	31	days	day	NNS
cord-022594-fx044gcd	337	32	)	)	-RRB-
cord-022594-fx044gcd	337	33	,	,	,
cord-022594-fx044gcd	337	34	with	with	IN
cord-022594-fx044gcd	337	35	or	or	CC
cord-022594-fx044gcd	337	36	without	without	IN
cord-022594-fx044gcd	337	37	a	a	DT
cord-022594-fx044gcd	337	38	period	period	NN
cord-022594-fx044gcd	337	39	of	of	IN
cord-022594-fx044gcd	337	40	stabilization	stabilization	NN
cord-022594-fx044gcd	337	41	,	,	,
cord-022594-fx044gcd	337	42	and	and	CC
cord-022594-fx044gcd	337	43	improvement	improvement	NN
cord-022594-fx044gcd	337	44	or	or	CC
cord-022594-fx044gcd	337	45	resolution	resolution	NN
cord-022594-fx044gcd	337	46	(	(	-LRB-
cord-022594-fx044gcd	337	47	often	often	RB
cord-022594-fx044gcd	337	48	over	over	IN
cord-022594-fx044gcd	337	49	months	month	NNS
cord-022594-fx044gcd	337	50	)	)	-RRB-
cord-022594-fx044gcd	337	51	.	.	.
cord-022594-fx044gcd	338	1	Insidious	insidious	JJ
cord-022594-fx044gcd	338	2	progression	progression	NN
cord-022594-fx044gcd	338	3	of	of	IN
cord-022594-fx044gcd	338	4	deficits	deficit	NNS
cord-022594-fx044gcd	338	5	localized	localize	VBN
cord-022594-fx044gcd	338	6	to	to	IN
cord-022594-fx044gcd	338	7	a	a	DT
cord-022594-fx044gcd	338	8	single	single	JJ
cord-022594-fx044gcd	338	9	site	site	NN
cord-022594-fx044gcd	338	10	in	in	IN
cord-022594-fx044gcd	338	11	the	the	DT
cord-022594-fx044gcd	338	12	CNS	CNS	NNP
cord-022594-fx044gcd	338	13	can	can	MD
cord-022594-fx044gcd	338	14	also	also	RB
cord-022594-fx044gcd	338	15	be	be	VB
cord-022594-fx044gcd	338	16	due	due	JJ
cord-022594-fx044gcd	338	17	to	to	IN
cord-022594-fx044gcd	338	18	MS	MS	NNP
cord-022594-fx044gcd	338	19	,	,	,
cord-022594-fx044gcd	338	20	but	but	CC
cord-022594-fx044gcd	338	21	other	other	JJ
cord-022594-fx044gcd	338	22	causes	cause	NNS
cord-022594-fx044gcd	338	23	must	must	MD
cord-022594-fx044gcd	338	24	be	be	VB
cord-022594-fx044gcd	338	25	excluded	exclude	VBN
cord-022594-fx044gcd	338	26	.	.	.
cord-022594-fx044gcd	339	1	The	the	DT
cord-022594-fx044gcd	339	2	temporal	temporal	JJ
cord-022594-fx044gcd	339	3	course	course	NN
cord-022594-fx044gcd	339	4	of	of	IN
cord-022594-fx044gcd	339	5	MS	MS	NNP
cord-022594-fx044gcd	339	6	can	can	MD
cord-022594-fx044gcd	339	7	be	be	VB
cord-022594-fx044gcd	339	8	described	describe	VBN
cord-022594-fx044gcd	339	9	by	by	IN
cord-022594-fx044gcd	339	10	one	one	CD
cord-022594-fx044gcd	339	11	of	of	IN
cord-022594-fx044gcd	339	12	four	four	CD
cord-022594-fx044gcd	339	13	categories	category	NNS
cord-022594-fx044gcd	339	14	:	:	:
cord-022594-fx044gcd	339	15	relapsing	relapse	VBG
cord-022594-fx044gcd	339	16	-	-	HYPH
cord-022594-fx044gcd	339	17	remitting	remit	VBG
cord-022594-fx044gcd	339	18	(	(	-LRB-
cord-022594-fx044gcd	339	19	RR	RR	NNP
cord-022594-fx044gcd	339	20	)	)	-RRB-
cord-022594-fx044gcd	339	21	,	,	,
cord-022594-fx044gcd	339	22	secondary	secondary	JJ
cord-022594-fx044gcd	339	23	progressive	progressive	JJ
cord-022594-fx044gcd	339	24	(	(	-LRB-
cord-022594-fx044gcd	339	25	SP	SP	NNP
cord-022594-fx044gcd	339	26	)	)	-RRB-
cord-022594-fx044gcd	339	27	,	,	,
cord-022594-fx044gcd	339	28	primary	primary	JJ
cord-022594-fx044gcd	339	29	progressive	progressive	NN
cord-022594-fx044gcd	339	30	(	(	-LRB-
cord-022594-fx044gcd	339	31	PP	PP	NNP
cord-022594-fx044gcd	339	32	)	)	-RRB-
cord-022594-fx044gcd	339	33	,	,	,
cord-022594-fx044gcd	339	34	and	and	CC
cord-022594-fx044gcd	339	35	progressive	progressive	JJ
cord-022594-fx044gcd	339	36	relapsing	relapsing	NN
cord-022594-fx044gcd	339	37	(	(	-LRB-
cord-022594-fx044gcd	339	38	PR	PR	NNP
cord-022594-fx044gcd	339	39	)	)	-RRB-
cord-022594-fx044gcd	339	40	.	.	.
cord-022594-fx044gcd	340	1	32	32	CD
cord-022594-fx044gcd	341	1	Many	many	JJ
cord-022594-fx044gcd	341	2	physicians	physician	NNS
cord-022594-fx044gcd	341	3	use	use	VBP
cord-022594-fx044gcd	341	4	the	the	DT
cord-022594-fx044gcd	341	5	term	term	NN
cord-022594-fx044gcd	341	6	relapsing	relapse	VBG
cord-022594-fx044gcd	341	7	progressive	progressive	JJ
cord-022594-fx044gcd	341	8	,	,	,
cord-022594-fx044gcd	341	9	which	which	WDT
cord-022594-fx044gcd	341	10	encompassed	encompass	VBD
cord-022594-fx044gcd	341	11	patients	patient	NNS
cord-022594-fx044gcd	341	12	with	with	IN
cord-022594-fx044gcd	341	13	SPMS	SPMS	NNP
cord-022594-fx044gcd	341	14	,	,	,
cord-022594-fx044gcd	341	15	PRMS	PRMS	NNP
cord-022594-fx044gcd	341	16	,	,	,
cord-022594-fx044gcd	341	17	and	and	CC
cord-022594-fx044gcd	341	18	even	even	RB
cord-022594-fx044gcd	341	19	those	those	DT
cord-022594-fx044gcd	341	20	with	with	IN
cord-022594-fx044gcd	341	21	RRMS	rrm	NNS
cord-022594-fx044gcd	341	22	who	who	WP
cord-022594-fx044gcd	341	23	have	have	VBP
cord-022594-fx044gcd	341	24	stepwise	stepwise	JJ
cord-022594-fx044gcd	341	25	relapse	relapse	NN
cord-022594-fx044gcd	341	26	-	-	HYPH
cord-022594-fx044gcd	341	27	related	relate	VBN
cord-022594-fx044gcd	341	28	worsening	worsen	VBG
cord-022594-fx044gcd	341	29	disability	disability	NN
cord-022594-fx044gcd	341	30	.	.	.
cord-022594-fx044gcd	342	1	This	this	DT
cord-022594-fx044gcd	342	2	term	term	NN
cord-022594-fx044gcd	342	3	has	have	VBZ
cord-022594-fx044gcd	342	4	recently	recently	RB
cord-022594-fx044gcd	342	5	been	be	VBN
cord-022594-fx044gcd	342	6	abandoned	abandon	VBN
cord-022594-fx044gcd	342	7	.	.	.
cord-022594-fx044gcd	343	1	Other	other	JJ
cord-022594-fx044gcd	343	2	terms	term	NNS
cord-022594-fx044gcd	343	3	that	that	WDT
cord-022594-fx044gcd	343	4	relate	relate	VBP
cord-022594-fx044gcd	343	5	to	to	IN
cord-022594-fx044gcd	343	6	the	the	DT
cord-022594-fx044gcd	343	7	course	course	NN
cord-022594-fx044gcd	343	8	of	of	IN
cord-022594-fx044gcd	343	9	MS	MS	NNP
cord-022594-fx044gcd	343	10	but	but	CC
cord-022594-fx044gcd	343	11	have	have	VBP
cord-022594-fx044gcd	343	12	no	no	DT
cord-022594-fx044gcd	343	13	consensus	consensus	NN
cord-022594-fx044gcd	343	14	regarding	regard	VBG
cord-022594-fx044gcd	343	15	their	-PRON-	PRP$
cord-022594-fx044gcd	343	16	definition	definition	NN
cord-022594-fx044gcd	343	17	are	be	VBP
cord-022594-fx044gcd	343	18	sometimes	sometimes	RB
cord-022594-fx044gcd	343	19	encountered	encounter	VBN
cord-022594-fx044gcd	343	20	.	.	.
cord-022594-fx044gcd	344	1	Benign	benign	JJ
cord-022594-fx044gcd	344	2	MS	MS	NNP
cord-022594-fx044gcd	344	3	generally	generally	RB
cord-022594-fx044gcd	344	4	refers	refer	VBZ
cord-022594-fx044gcd	344	5	to	to	IN
cord-022594-fx044gcd	344	6	patients	patient	NNS
cord-022594-fx044gcd	344	7	who	who	WP
cord-022594-fx044gcd	344	8	have	have	VBP
cord-022594-fx044gcd	344	9	had	have	VBN
cord-022594-fx044gcd	344	10	MS	MS	NNP
cord-022594-fx044gcd	344	11	for	for	IN
cord-022594-fx044gcd	344	12	a	a	DT
cord-022594-fx044gcd	344	13	long	long	JJ
cord-022594-fx044gcd	344	14	time	time	NN
cord-022594-fx044gcd	344	15	but	but	CC
cord-022594-fx044gcd	344	16	have	have	VBP
cord-022594-fx044gcd	344	17	little	little	JJ
cord-022594-fx044gcd	344	18	or	or	CC
cord-022594-fx044gcd	344	19	no	no	DT
cord-022594-fx044gcd	344	20	disability	disability	NN
cord-022594-fx044gcd	344	21	.	.	.
cord-022594-fx044gcd	345	1	Malignant	malignant	JJ
cord-022594-fx044gcd	345	2	MS	MS	NNP
cord-022594-fx044gcd	345	3	is	be	VBZ
cord-022594-fx044gcd	345	4	sometimes	sometimes	RB
cord-022594-fx044gcd	345	5	used	use	VBN
cord-022594-fx044gcd	345	6	to	to	TO
cord-022594-fx044gcd	345	7	describe	describe	VB
cord-022594-fx044gcd	345	8	patients	patient	NNS
cord-022594-fx044gcd	345	9	with	with	IN
cord-022594-fx044gcd	345	10	frequent	frequent	JJ
cord-022594-fx044gcd	345	11	relapses	relapse	NNS
cord-022594-fx044gcd	345	12	and	and	CC
cord-022594-fx044gcd	345	13	incomplete	incomplete	JJ
cord-022594-fx044gcd	345	14	recovery	recovery	NN
cord-022594-fx044gcd	345	15	but	but	CC
cord-022594-fx044gcd	345	16	is	be	VBZ
cord-022594-fx044gcd	345	17	also	also	RB
cord-022594-fx044gcd	345	18	used	use	VBN
cord-022594-fx044gcd	345	19	in	in	IN
cord-022594-fx044gcd	345	20	reference	reference	NN
cord-022594-fx044gcd	345	21	to	to	IN
cord-022594-fx044gcd	345	22	patients	patient	NNS
cord-022594-fx044gcd	345	23	with	with	IN
cord-022594-fx044gcd	345	24	acute	acute	JJ
cord-022594-fx044gcd	345	25	fulminant	fulminant	JJ
cord-022594-fx044gcd	345	26	demyelinating	demyelinating	NN
cord-022594-fx044gcd	345	27	syndromes	syndrome	NNS
cord-022594-fx044gcd	345	28	(	(	-LRB-
cord-022594-fx044gcd	345	29	see	see	VB
cord-022594-fx044gcd	345	30	later	later	RB
cord-022594-fx044gcd	345	31	)	)	-RRB-
cord-022594-fx044gcd	345	32	.	.	.
cord-022594-fx044gcd	346	1	The	the	DT
cord-022594-fx044gcd	346	2	term	term	NN
cord-022594-fx044gcd	346	3	clinically	clinically	RB
cord-022594-fx044gcd	346	4	isolated	isolated	JJ
cord-022594-fx044gcd	346	5	syndrome	syndrome	NN
cord-022594-fx044gcd	346	6	(	(	-LRB-
cord-022594-fx044gcd	346	7	CIS	CIS	NNP
cord-022594-fx044gcd	346	8	)	)	-RRB-
cord-022594-fx044gcd	346	9	refers	refer	VBZ
cord-022594-fx044gcd	346	10	to	to	IN
cord-022594-fx044gcd	346	11	patients	patient	NNS
cord-022594-fx044gcd	346	12	presenting	present	VBG
cord-022594-fx044gcd	346	13	with	with	IN
cord-022594-fx044gcd	346	14	their	-PRON-	PRP$
cord-022594-fx044gcd	346	15	first	first	JJ
cord-022594-fx044gcd	346	16	episode	episode	NN
cord-022594-fx044gcd	346	17	of	of	IN
cord-022594-fx044gcd	346	18	region	region	NN
cord-022594-fx044gcd	346	19	-	-	HYPH
cord-022594-fx044gcd	346	20	restricted	restrict	VBN
cord-022594-fx044gcd	346	21	episodes	episode	NNS
cord-022594-fx044gcd	346	22	of	of	IN
cord-022594-fx044gcd	346	23	CNS	CNS	NNP
cord-022594-fx044gcd	346	24	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	346	25	demyelination	demyelination	NN
cord-022594-fx044gcd	346	26	.	.	.
cord-022594-fx044gcd	347	1	This	this	DT
cord-022594-fx044gcd	347	2	may	may	MD
cord-022594-fx044gcd	347	3	remain	remain	VB
cord-022594-fx044gcd	347	4	an	an	DT
cord-022594-fx044gcd	347	5	isolated	isolated	JJ
cord-022594-fx044gcd	347	6	syndrome	syndrome	NN
cord-022594-fx044gcd	347	7	(	(	-LRB-
cord-022594-fx044gcd	347	8	no	no	DT
cord-022594-fx044gcd	347	9	recurrence	recurrence	NN
cord-022594-fx044gcd	347	10	)	)	-RRB-
cord-022594-fx044gcd	347	11	,	,	,
cord-022594-fx044gcd	347	12	it	-PRON-	PRP
cord-022594-fx044gcd	347	13	may	may	MD
cord-022594-fx044gcd	347	14	remain	remain	VB
cord-022594-fx044gcd	347	15	a	a	DT
cord-022594-fx044gcd	347	16	forme	forme	FW
cord-022594-fx044gcd	347	17	fruste	fruste	NN
cord-022594-fx044gcd	347	18	of	of	IN
cord-022594-fx044gcd	347	19	acute	acute	JJ
cord-022594-fx044gcd	347	20	disseminated	disseminate	VBN
cord-022594-fx044gcd	347	21	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	347	22	(	(	-LRB-
cord-022594-fx044gcd	347	23	ADEM	ADEM	NNP
cord-022594-fx044gcd	347	24	)	)	-RRB-
cord-022594-fx044gcd	347	25	,	,	,
cord-022594-fx044gcd	347	26	or	or	CC
cord-022594-fx044gcd	347	27	it	-PRON-	PRP
cord-022594-fx044gcd	347	28	may	may	MD
cord-022594-fx044gcd	347	29	be	be	VB
cord-022594-fx044gcd	347	30	the	the	DT
cord-022594-fx044gcd	347	31	harbinger	harbinger	NN
cord-022594-fx044gcd	347	32	for	for	IN
cord-022594-fx044gcd	347	33	one	one	CD
cord-022594-fx044gcd	347	34	of	of	IN
cord-022594-fx044gcd	347	35	the	the	DT
cord-022594-fx044gcd	347	36	relapsing	relapse	VBG
cord-022594-fx044gcd	347	37	forms	form	NNS
cord-022594-fx044gcd	347	38	of	of	IN
cord-022594-fx044gcd	347	39	MS	MS	NNP
cord-022594-fx044gcd	347	40	.	.	.
cord-022594-fx044gcd	348	1	The	the	DT
cord-022594-fx044gcd	348	2	probability	probability	NN
cord-022594-fx044gcd	348	3	of	of	IN
cord-022594-fx044gcd	348	4	recurrent	recurrent	JJ
cord-022594-fx044gcd	348	5	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	348	6	episodes	episode	NNS
cord-022594-fx044gcd	348	7	(	(	-LRB-
cord-022594-fx044gcd	348	8	e.g.	e.g.	RB
cord-022594-fx044gcd	348	9	,	,	,
cord-022594-fx044gcd	348	10	clinically	clinically	RB
cord-022594-fx044gcd	348	11	definite	definite	JJ
cord-022594-fx044gcd	348	12	MS	MS	NNP
cord-022594-fx044gcd	348	13	)	)	-RRB-
cord-022594-fx044gcd	348	14	has	have	VBZ
cord-022594-fx044gcd	348	15	been	be	VBN
cord-022594-fx044gcd	348	16	the	the	DT
cord-022594-fx044gcd	348	17	subject	subject	NN
cord-022594-fx044gcd	348	18	of	of	IN
cord-022594-fx044gcd	348	19	several	several	JJ
cord-022594-fx044gcd	348	20	important	important	JJ
cord-022594-fx044gcd	348	21	investigations	investigation	NNS
cord-022594-fx044gcd	348	22	,	,	,
cord-022594-fx044gcd	348	23	and	and	CC
cord-022594-fx044gcd	348	24	several	several	JJ
cord-022594-fx044gcd	348	25	clinical	clinical	JJ
cord-022594-fx044gcd	348	26	features	feature	NNS
cord-022594-fx044gcd	348	27	and	and	CC
cord-022594-fx044gcd	348	28	test	test	NN
cord-022594-fx044gcd	348	29	results	result	NNS
cord-022594-fx044gcd	348	30	are	be	VBP
cord-022594-fx044gcd	348	31	of	of	IN
cord-022594-fx044gcd	348	32	predictive	predictive	JJ
cord-022594-fx044gcd	348	33	value	value	NN
cord-022594-fx044gcd	348	34	.	.	.
cord-022594-fx044gcd	349	1	Optic	optic	JJ
cord-022594-fx044gcd	349	2	nerve	nerve	NN
cord-022594-fx044gcd	349	3	,	,	,
cord-022594-fx044gcd	349	4	spinal	spinal	JJ
cord-022594-fx044gcd	349	5	cord	cord	NN
cord-022594-fx044gcd	349	6	,	,	,
cord-022594-fx044gcd	349	7	and	and	CC
cord-022594-fx044gcd	349	8	brain	brain	NN
cord-022594-fx044gcd	349	9	stem	stem	NN
cord-022594-fx044gcd	349	10	are	be	VBP
cord-022594-fx044gcd	349	11	the	the	DT
cord-022594-fx044gcd	349	12	most	most	RBS
cord-022594-fx044gcd	349	13	common	common	JJ
cord-022594-fx044gcd	349	14	sites	site	NNS
cord-022594-fx044gcd	349	15	of	of	IN
cord-022594-fx044gcd	349	16	these	these	DT
cord-022594-fx044gcd	349	17	recurrent	recurrent	JJ
cord-022594-fx044gcd	349	18	monosymptomatic	monosymptomatic	JJ
cord-022594-fx044gcd	349	19	events	event	NNS
cord-022594-fx044gcd	349	20	,	,	,
cord-022594-fx044gcd	349	21	and	and	CC
cord-022594-fx044gcd	349	22	the	the	DT
cord-022594-fx044gcd	349	23	time	time	NN
cord-022594-fx044gcd	349	24	profile	profile	NN
cord-022594-fx044gcd	349	25	follows	follow	VBZ
cord-022594-fx044gcd	349	26	that	that	DT
cord-022594-fx044gcd	349	27	of	of	IN
cord-022594-fx044gcd	349	28	MS	MS	NNP
cord-022594-fx044gcd	349	29	relapses	relapse	NNS
cord-022594-fx044gcd	349	30	.	.	.
cord-022594-fx044gcd	350	1	The	the	DT
cord-022594-fx044gcd	350	2	pathogenesis	pathogenesis	NN
cord-022594-fx044gcd	350	3	,	,	,
cord-022594-fx044gcd	350	4	pathophysiology	pathophysiology	NN
cord-022594-fx044gcd	350	5	,	,	,
cord-022594-fx044gcd	350	6	epidemiology	epidemiology	NN
cord-022594-fx044gcd	350	7	,	,	,
cord-022594-fx044gcd	350	8	clinical	clinical	JJ
cord-022594-fx044gcd	350	9	features	feature	NNS
cord-022594-fx044gcd	350	10	,	,	,
cord-022594-fx044gcd	350	11	associated	associated	JJ
cord-022594-fx044gcd	350	12	disorders	disorder	NNS
cord-022594-fx044gcd	350	13	,	,	,
cord-022594-fx044gcd	350	14	differential	differential	JJ
cord-022594-fx044gcd	350	15	diagnosis	diagnosis	NN
cord-022594-fx044gcd	350	16	,	,	,
cord-022594-fx044gcd	350	17	evaluation	evaluation	NN
cord-022594-fx044gcd	350	18	,	,	,
cord-022594-fx044gcd	350	19	and	and	CC
cord-022594-fx044gcd	350	20	management	management	NN
cord-022594-fx044gcd	350	21	are	be	VBP
cord-022594-fx044gcd	350	22	the	the	DT
cord-022594-fx044gcd	350	23	same	same	JJ
cord-022594-fx044gcd	350	24	as	as	IN
cord-022594-fx044gcd	350	25	in	in	IN
cord-022594-fx044gcd	350	26	MS	MS	NNP
cord-022594-fx044gcd	350	27	.	.	.
cord-022594-fx044gcd	351	1	The	the	DT
cord-022594-fx044gcd	351	2	prognosis	prognosis	NN
cord-022594-fx044gcd	351	3	for	for	IN
cord-022594-fx044gcd	351	4	visual	visual	JJ
cord-022594-fx044gcd	351	5	recovery	recovery	NN
cord-022594-fx044gcd	351	6	after	after	IN
cord-022594-fx044gcd	351	7	each	each	DT
cord-022594-fx044gcd	351	8	episode	episode	NN
cord-022594-fx044gcd	351	9	of	of	IN
cord-022594-fx044gcd	351	10	ON	ON	NNP
cord-022594-fx044gcd	351	11	is	be	VBZ
cord-022594-fx044gcd	351	12	good	good	JJ
cord-022594-fx044gcd	351	13	,	,	,
cord-022594-fx044gcd	351	14	and	and	CC
cord-022594-fx044gcd	351	15	most	most	JJS
cord-022594-fx044gcd	351	16	patients	patient	NNS
cord-022594-fx044gcd	351	17	regain	regain	VBP
cord-022594-fx044gcd	351	18	normal	normal	JJ
cord-022594-fx044gcd	351	19	visual	visual	JJ
cord-022594-fx044gcd	351	20	acuity	acuity	NN
cord-022594-fx044gcd	351	21	.	.	.
cord-022594-fx044gcd	352	1	Profound	profound	JJ
cord-022594-fx044gcd	352	2	visual	visual	JJ
cord-022594-fx044gcd	352	3	loss	loss	NN
cord-022594-fx044gcd	352	4	,	,	,
cord-022594-fx044gcd	352	5	recurrent	recurrent	JJ
cord-022594-fx044gcd	352	6	ON	ON	NNP
cord-022594-fx044gcd	352	7	,	,	,
cord-022594-fx044gcd	352	8	and	and	CC
cord-022594-fx044gcd	352	9	age	age	NN
cord-022594-fx044gcd	352	10	older	old	JJR
cord-022594-fx044gcd	352	11	than	than	IN
cord-022594-fx044gcd	352	12	35	35	CD
cord-022594-fx044gcd	352	13	are	be	VBP
cord-022594-fx044gcd	352	14	associated	associate	VBN
cord-022594-fx044gcd	352	15	with	with	IN
cord-022594-fx044gcd	352	16	a	a	DT
cord-022594-fx044gcd	352	17	higher	high	JJR
cord-022594-fx044gcd	352	18	risk	risk	NN
cord-022594-fx044gcd	352	19	for	for	IN
cord-022594-fx044gcd	352	20	poor	poor	JJ
cord-022594-fx044gcd	352	21	recovery	recovery	NN
cord-022594-fx044gcd	352	22	.	.	.
cord-022594-fx044gcd	353	1	Investigators	investigator	NNS
cord-022594-fx044gcd	353	2	have	have	VBP
cord-022594-fx044gcd	353	3	concluded	conclude	VBN
cord-022594-fx044gcd	353	4	that	that	IN
cord-022594-fx044gcd	353	5	recurrent	recurrent	JJ
cord-022594-fx044gcd	353	6	multifocal	multifocal	JJ
cord-022594-fx044gcd	353	7	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	353	8	episodes	episode	NNS
cord-022594-fx044gcd	353	9	,	,	,
cord-022594-fx044gcd	353	10	fulfilling	fulfil	VBG
cord-022594-fx044gcd	353	11	the	the	DT
cord-022594-fx044gcd	353	12	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	353	13	requirements	requirement	NNS
cord-022594-fx044gcd	353	14	of	of	IN
cord-022594-fx044gcd	353	15	clinically	clinically	RB
cord-022594-fx044gcd	353	16	definite	definite	JJ
cord-022594-fx044gcd	353	17	MS	MS	NNP
cord-022594-fx044gcd	353	18	,	,	,
cord-022594-fx044gcd	353	19	develop	develop	VB
cord-022594-fx044gcd	353	20	in	in	IN
cord-022594-fx044gcd	353	21	50	50	CD
cord-022594-fx044gcd	353	22	%	%	NN
cord-022594-fx044gcd	353	23	or	or	CC
cord-022594-fx044gcd	353	24	more	more	JJR
cord-022594-fx044gcd	353	25	of	of	IN
cord-022594-fx044gcd	353	26	patients	patient	NNS
cord-022594-fx044gcd	353	27	after	after	IN
cord-022594-fx044gcd	353	28	isolated	isolate	VBN
cord-022594-fx044gcd	353	29	ON	on	IN
cord-022594-fx044gcd	353	30	when	when	WRB
cord-022594-fx044gcd	353	31	follow	follow	NN
cord-022594-fx044gcd	353	32	-	-	HYPH
cord-022594-fx044gcd	353	33	up	up	NN
cord-022594-fx044gcd	353	34	is	be	VBZ
cord-022594-fx044gcd	353	35	extended	extend	VBN
cord-022594-fx044gcd	353	36	beyond	beyond	IN
cord-022594-fx044gcd	353	37	20	20	CD
cord-022594-fx044gcd	353	38	years	year	NNS
cord-022594-fx044gcd	353	39	.	.	.
cord-022594-fx044gcd	354	1	36	36	CD
cord-022594-fx044gcd	354	2	Most	Most	JJS
cord-022594-fx044gcd	354	3	of	of	IN
cord-022594-fx044gcd	354	4	this	this	DT
cord-022594-fx044gcd	354	5	risk	risk	NN
cord-022594-fx044gcd	354	6	is	be	VBZ
cord-022594-fx044gcd	354	7	incurred	incur	VBN
cord-022594-fx044gcd	354	8	within	within	IN
cord-022594-fx044gcd	354	9	the	the	DT
cord-022594-fx044gcd	354	10	first	first	JJ
cord-022594-fx044gcd	354	11	few	few	JJ
cord-022594-fx044gcd	354	12	years	year	NNS
cord-022594-fx044gcd	354	13	,	,	,
cord-022594-fx044gcd	354	14	although	although	IN
cord-022594-fx044gcd	354	15	significant	significant	JJ
cord-022594-fx044gcd	354	16	risk	risk	NN
cord-022594-fx044gcd	354	17	may	may	MD
cord-022594-fx044gcd	354	18	continue	continue	VB
cord-022594-fx044gcd	354	19	into	into	IN
cord-022594-fx044gcd	354	20	the	the	DT
cord-022594-fx044gcd	354	21	fourth	fourth	JJ
cord-022594-fx044gcd	354	22	decade	decade	NN
cord-022594-fx044gcd	354	23	after	after	IN
cord-022594-fx044gcd	354	24	the	the	DT
cord-022594-fx044gcd	354	25	event	event	NN
cord-022594-fx044gcd	354	26	.	.	.
cord-022594-fx044gcd	355	1	Children	child	NNS
cord-022594-fx044gcd	355	2	much	much	RB
cord-022594-fx044gcd	355	3	more	more	RBR
cord-022594-fx044gcd	355	4	often	often	RB
cord-022594-fx044gcd	355	5	develop	develop	VBP
cord-022594-fx044gcd	355	6	simultaneous	simultaneous	JJ
cord-022594-fx044gcd	355	7	bilateral	bilateral	JJ
cord-022594-fx044gcd	355	8	ON	on	NN
cord-022594-fx044gcd	355	9	and	and	CC
cord-022594-fx044gcd	355	10	have	have	VB
cord-022594-fx044gcd	355	11	a	a	DT
cord-022594-fx044gcd	355	12	lower	low	JJR
cord-022594-fx044gcd	355	13	risk	risk	NN
cord-022594-fx044gcd	355	14	for	for	IN
cord-022594-fx044gcd	355	15	subsequent	subsequent	JJ
cord-022594-fx044gcd	355	16	MS	MS	NNP
cord-022594-fx044gcd	355	17	than	than	IN
cord-022594-fx044gcd	355	18	adults	adult	NNS
cord-022594-fx044gcd	355	19	.	.	.
cord-022594-fx044gcd	356	1	Factors	factor	NNS
cord-022594-fx044gcd	356	2	that	that	WDT
cord-022594-fx044gcd	356	3	are	be	VBP
cord-022594-fx044gcd	356	4	associated	associate	VBN
cord-022594-fx044gcd	356	5	with	with	IN
cord-022594-fx044gcd	356	6	an	an	DT
cord-022594-fx044gcd	356	7	increased	increase	VBN
cord-022594-fx044gcd	356	8	risk	risk	NN
cord-022594-fx044gcd	356	9	of	of	IN
cord-022594-fx044gcd	356	10	developing	develop	VBG
cord-022594-fx044gcd	356	11	MS	MS	NNP
cord-022594-fx044gcd	356	12	as	as	IN
cord-022594-fx044gcd	356	13	a	a	DT
cord-022594-fx044gcd	356	14	disseminated	disseminate	VBN
cord-022594-fx044gcd	356	15	illness	illness	NN
cord-022594-fx044gcd	356	16	are	be	VBP
cord-022594-fx044gcd	356	17	the	the	DT
cord-022594-fx044gcd	356	18	presence	presence	NN
cord-022594-fx044gcd	356	19	of	of	IN
cord-022594-fx044gcd	356	20	venous	venous	JJ
cord-022594-fx044gcd	356	21	sheathing	sheathing	NN
cord-022594-fx044gcd	356	22	,	,	,
cord-022594-fx044gcd	356	23	recurrent	recurrent	JJ
cord-022594-fx044gcd	356	24	ON	on	IN
cord-022594-fx044gcd	356	25	,	,	,
cord-022594-fx044gcd	356	26	family	family	NN
cord-022594-fx044gcd	356	27	history	history	NN
cord-022594-fx044gcd	356	28	of	of	IN
cord-022594-fx044gcd	356	29	MS	MS	NNP
cord-022594-fx044gcd	356	30	,	,	,
cord-022594-fx044gcd	356	31	white	white	JJ
cord-022594-fx044gcd	356	32	race	race	NN
cord-022594-fx044gcd	356	33	,	,	,
cord-022594-fx044gcd	356	34	previous	previous	JJ
cord-022594-fx044gcd	356	35	vague	vague	JJ
cord-022594-fx044gcd	356	36	or	or	CC
cord-022594-fx044gcd	356	37	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	356	38	neurological	neurological	JJ
cord-022594-fx044gcd	356	39	symptoms	symptom	NNS
cord-022594-fx044gcd	356	40	,	,	,
cord-022594-fx044gcd	356	41	and	and	CC
cord-022594-fx044gcd	356	42	the	the	DT
cord-022594-fx044gcd	356	43	presence	presence	NN
cord-022594-fx044gcd	356	44	of	of	IN
cord-022594-fx044gcd	356	45	oligoclonal	oligoclonal	JJ
cord-022594-fx044gcd	356	46	bands	band	NNS
cord-022594-fx044gcd	356	47	(	(	-LRB-
cord-022594-fx044gcd	356	48	OCBs	OCBs	NNP
cord-022594-fx044gcd	356	49	)	)	-RRB-
cord-022594-fx044gcd	356	50	,	,	,
cord-022594-fx044gcd	356	51	elevated	elevated	JJ
cord-022594-fx044gcd	356	52	IgG	IgG	NNP
cord-022594-fx044gcd	356	53	index	index	NN
cord-022594-fx044gcd	356	54	,	,	,
cord-022594-fx044gcd	356	55	or	or	CC
cord-022594-fx044gcd	356	56	IgG	IgG	NNP
cord-022594-fx044gcd	356	57	synthesis	synthesis	NN
cord-022594-fx044gcd	356	58	rate	rate	NN
cord-022594-fx044gcd	356	59	in	in	IN
cord-022594-fx044gcd	356	60	CSF	CSF	NNP
cord-022594-fx044gcd	356	61	.	.	.
cord-022594-fx044gcd	357	1	The	the	DT
cord-022594-fx044gcd	357	2	severity	severity	NN
cord-022594-fx044gcd	357	3	of	of	IN
cord-022594-fx044gcd	357	4	acute	acute	JJ
cord-022594-fx044gcd	357	5	transverse	transverse	JJ
cord-022594-fx044gcd	357	6	myelitis	myelitis	NN
cord-022594-fx044gcd	357	7	is	be	VBZ
cord-022594-fx044gcd	357	8	inversely	inversely	RB
cord-022594-fx044gcd	357	9	related	relate	VBN
cord-022594-fx044gcd	357	10	to	to	IN
cord-022594-fx044gcd	357	11	the	the	DT
cord-022594-fx044gcd	357	12	risk	risk	NN
cord-022594-fx044gcd	357	13	of	of	IN
cord-022594-fx044gcd	357	14	acquiring	acquire	VBG
cord-022594-fx044gcd	357	15	further	further	JJ
cord-022594-fx044gcd	357	16	symptomatic	symptomatic	JJ
cord-022594-fx044gcd	357	17	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	357	18	lesions	lesion	NNS
cord-022594-fx044gcd	357	19	.	.	.
cord-022594-fx044gcd	358	1	Complete	complete	VB
cord-022594-fx044gcd	358	2	transverse	transverse	JJ
cord-022594-fx044gcd	358	3	myelitis	myelitis	NN
cord-022594-fx044gcd	358	4	with	with	IN
cord-022594-fx044gcd	358	5	profound	profound	JJ
cord-022594-fx044gcd	358	6	loss	loss	NN
cord-022594-fx044gcd	358	7	of	of	IN
cord-022594-fx044gcd	358	8	motor	motor	NN
cord-022594-fx044gcd	358	9	,	,	,
cord-022594-fx044gcd	358	10	sensory	sensory	JJ
cord-022594-fx044gcd	358	11	,	,	,
cord-022594-fx044gcd	358	12	and	and	CC
cord-022594-fx044gcd	358	13	sphincter	sphincter	NN
cord-022594-fx044gcd	358	14	function	function	NN
cord-022594-fx044gcd	358	15	imparts	impart	VBZ
cord-022594-fx044gcd	358	16	a	a	DT
cord-022594-fx044gcd	358	17	relatively	relatively	RB
cord-022594-fx044gcd	358	18	low	low	JJ
cord-022594-fx044gcd	358	19	risk	risk	NN
cord-022594-fx044gcd	358	20	of	of	IN
cord-022594-fx044gcd	358	21	3	3	CD
cord-022594-fx044gcd	358	22	to	to	TO
cord-022594-fx044gcd	358	23	14	14	CD
cord-022594-fx044gcd	358	24	for	for	IN
cord-022594-fx044gcd	358	25	the	the	DT
cord-022594-fx044gcd	358	26	later	later	JJ
cord-022594-fx044gcd	358	27	diagnosis	diagnosis	NN
cord-022594-fx044gcd	358	28	of	of	IN
cord-022594-fx044gcd	358	29	MS	MS	NNP
cord-022594-fx044gcd	358	30	.	.	.
cord-022594-fx044gcd	359	1	Partial	partial	JJ
cord-022594-fx044gcd	359	2	transverse	transverse	JJ
cord-022594-fx044gcd	359	3	myelitis	myelitis	NN
cord-022594-fx044gcd	359	4	with	with	IN
cord-022594-fx044gcd	359	5	preservation	preservation	NN
cord-022594-fx044gcd	359	6	of	of	IN
cord-022594-fx044gcd	359	7	significant	significant	JJ
cord-022594-fx044gcd	359	8	motor	motor	NN
cord-022594-fx044gcd	359	9	function	function	NN
cord-022594-fx044gcd	359	10	at	at	IN
cord-022594-fx044gcd	359	11	peak	peak	NN
cord-022594-fx044gcd	359	12	is	be	VBZ
cord-022594-fx044gcd	359	13	associated	associate	VBN
cord-022594-fx044gcd	359	14	with	with	IN
cord-022594-fx044gcd	359	15	a	a	DT
cord-022594-fx044gcd	359	16	much	much	RB
cord-022594-fx044gcd	359	17	higher	high	JJR
cord-022594-fx044gcd	359	18	incidence	incidence	NN
cord-022594-fx044gcd	359	19	of	of	IN
cord-022594-fx044gcd	359	20	MS	MS	NNP
cord-022594-fx044gcd	359	21	.	.	.
cord-022594-fx044gcd	360	1	Although	although	IN
cord-022594-fx044gcd	360	2	monosymptomatic	monosymptomatic	JJ
cord-022594-fx044gcd	360	3	brain	brain	NN
cord-022594-fx044gcd	360	4	stem	stem	NN
cord-022594-fx044gcd	360	5	demyelination	demyelination	NN
cord-022594-fx044gcd	360	6	is	be	VBZ
cord-022594-fx044gcd	360	7	not	not	RB
cord-022594-fx044gcd	360	8	as	as	RB
cord-022594-fx044gcd	360	9	common	common	JJ
cord-022594-fx044gcd	360	10	as	as	IN
cord-022594-fx044gcd	360	11	either	either	CC
cord-022594-fx044gcd	360	12	ON	on	JJ
cord-022594-fx044gcd	360	13	or	or	CC
cord-022594-fx044gcd	360	14	acute	acute	JJ
cord-022594-fx044gcd	360	15	transverse	transverse	JJ
cord-022594-fx044gcd	360	16	myelitis	myelitis	NN
cord-022594-fx044gcd	360	17	,	,	,
cord-022594-fx044gcd	360	18	similar	similar	JJ
cord-022594-fx044gcd	360	19	conclusions	conclusion	NNS
cord-022594-fx044gcd	360	20	have	have	VBP
cord-022594-fx044gcd	360	21	been	be	VBN
cord-022594-fx044gcd	360	22	reached	reach	VBN
cord-022594-fx044gcd	360	23	.	.	.
cord-022594-fx044gcd	361	1	In	in	IN
cord-022594-fx044gcd	361	2	the	the	DT
cord-022594-fx044gcd	361	3	only	only	JJ
cord-022594-fx044gcd	361	4	study	study	NN
cord-022594-fx044gcd	361	5	available	available	JJ
cord-022594-fx044gcd	361	6	,	,	,
cord-022594-fx044gcd	361	7	two	two	CD
cord-022594-fx044gcd	361	8	thirds	third	NNS
cord-022594-fx044gcd	361	9	of	of	IN
cord-022594-fx044gcd	361	10	these	these	DT
cord-022594-fx044gcd	361	11	patients	patient	NNS
cord-022594-fx044gcd	361	12	with	with	IN
cord-022594-fx044gcd	361	13	cerebral	cerebral	JJ
cord-022594-fx044gcd	361	14	white	white	JJ
cord-022594-fx044gcd	361	15	matter	matter	NN
cord-022594-fx044gcd	361	16	lesions	lesion	NNS
cord-022594-fx044gcd	361	17	detected	detect	VBN
cord-022594-fx044gcd	361	18	on	on	IN
cord-022594-fx044gcd	361	19	MRI	MRI	NNP
cord-022594-fx044gcd	361	20	developed	develop	VBD
cord-022594-fx044gcd	361	21	MS	MS	NNP
cord-022594-fx044gcd	361	22	within	within	IN
cord-022594-fx044gcd	361	23	5	5	CD
cord-022594-fx044gcd	361	24	years	year	NNS
cord-022594-fx044gcd	361	25	,	,	,
cord-022594-fx044gcd	361	26	compared	compare	VBN
cord-022594-fx044gcd	361	27	with	with	IN
cord-022594-fx044gcd	361	28	none	none	NN
cord-022594-fx044gcd	361	29	of	of	IN
cord-022594-fx044gcd	361	30	5	5	CD
cord-022594-fx044gcd	361	31	patients	patient	NNS
cord-022594-fx044gcd	361	32	with	with	IN
cord-022594-fx044gcd	361	33	normal	normal	JJ
cord-022594-fx044gcd	361	34	head	head	NN
cord-022594-fx044gcd	361	35	MRI	MRI	NNP
cord-022594-fx044gcd	361	36	.	.	.
cord-022594-fx044gcd	362	1	37	37	CD
cord-022594-fx044gcd	362	2	,	,	,
cord-022594-fx044gcd	362	3	38	38	CD
cord-022594-fx044gcd	362	4	A	a	DT
cord-022594-fx044gcd	362	5	recently	recently	RB
cord-022594-fx044gcd	362	6	published	publish	VBN
cord-022594-fx044gcd	362	7	10-year	10-year	CD
cord-022594-fx044gcd	362	8	follow	follow	NN
cord-022594-fx044gcd	362	9	-	-	HYPH
cord-022594-fx044gcd	362	10	up	up	NN
cord-022594-fx044gcd	362	11	of	of	IN
cord-022594-fx044gcd	362	12	the	the	DT
cord-022594-fx044gcd	362	13	original	original	JJ
cord-022594-fx044gcd	362	14	Queen	Queen	NNP
cord-022594-fx044gcd	362	15	Square	Square	NNP
cord-022594-fx044gcd	362	16	series	series	NN
cord-022594-fx044gcd	362	17	continues	continue	VBZ
cord-022594-fx044gcd	362	18	to	to	TO
cord-022594-fx044gcd	362	19	demonstrate	demonstrate	VB
cord-022594-fx044gcd	362	20	the	the	DT
cord-022594-fx044gcd	362	21	value	value	NN
cord-022594-fx044gcd	362	22	of	of	IN
cord-022594-fx044gcd	362	23	the	the	DT
cord-022594-fx044gcd	362	24	baseline	baseline	JJ
cord-022594-fx044gcd	362	25	cranial	cranial	JJ
cord-022594-fx044gcd	362	26	MRI	MRI	NNP
cord-022594-fx044gcd	362	27	study	study	NN
cord-022594-fx044gcd	362	28	in	in	IN
cord-022594-fx044gcd	362	29	determining	determine	VBG
cord-022594-fx044gcd	362	30	risk	risk	NN
cord-022594-fx044gcd	362	31	of	of	IN
cord-022594-fx044gcd	362	32	recurrence	recurrence	NN
cord-022594-fx044gcd	362	33	(	(	-LRB-
cord-022594-fx044gcd	362	34	MS	MS	NNP
cord-022594-fx044gcd	362	35	risk	risk	NN
cord-022594-fx044gcd	362	36	)	)	-RRB-
cord-022594-fx044gcd	362	37	.	.	.
cord-022594-fx044gcd	363	1	In	in	IN
cord-022594-fx044gcd	363	2	this	this	DT
cord-022594-fx044gcd	363	3	cohort	cohort	NN
cord-022594-fx044gcd	363	4	study	study	NN
cord-022594-fx044gcd	363	5	of	of	IN
cord-022594-fx044gcd	363	6	81	81	CD
cord-022594-fx044gcd	363	7	CIS	CIS	NNP
cord-022594-fx044gcd	363	8	patients	patient	NNS
cord-022594-fx044gcd	363	9	,	,	,
cord-022594-fx044gcd	363	10	approximately	approximately	RB
cord-022594-fx044gcd	363	11	two	two	CD
cord-022594-fx044gcd	363	12	thirds	third	NNS
cord-022594-fx044gcd	363	13	had	have	VBD
cord-022594-fx044gcd	363	14	at	at	RB
cord-022594-fx044gcd	363	15	least	least	RBS
cord-022594-fx044gcd	363	16	one	one	CD
cord-022594-fx044gcd	363	17	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	363	18	lesion	lesion	NN
cord-022594-fx044gcd	363	19	(	(	-LRB-
cord-022594-fx044gcd	363	20	54	54	CD
cord-022594-fx044gcd	363	21	of	of	IN
cord-022594-fx044gcd	363	22	81	81	CD
cord-022594-fx044gcd	363	23	,	,	,
cord-022594-fx044gcd	363	24	67	67	CD
cord-022594-fx044gcd	363	25	%	%	NN
cord-022594-fx044gcd	363	26	)	)	-RRB-
cord-022594-fx044gcd	363	27	at	at	IN
cord-022594-fx044gcd	363	28	baseline	baseline	NN
cord-022594-fx044gcd	363	29	.	.	.
cord-022594-fx044gcd	364	1	After	after	IN
cord-022594-fx044gcd	364	2	5	5	CD
cord-022594-fx044gcd	364	3	years	year	NNS
cord-022594-fx044gcd	364	4	of	of	IN
cord-022594-fx044gcd	364	5	follow	follow	NN
cord-022594-fx044gcd	364	6	-	-	HYPH
cord-022594-fx044gcd	364	7	up	up	NN
cord-022594-fx044gcd	364	8	,	,	,
cord-022594-fx044gcd	364	9	slightly	slightly	RB
cord-022594-fx044gcd	364	10	more	more	JJR
cord-022594-fx044gcd	364	11	than	than	IN
cord-022594-fx044gcd	364	12	half	half	NN
cord-022594-fx044gcd	364	13	with	with	IN
cord-022594-fx044gcd	364	14	one	one	CD
cord-022594-fx044gcd	364	15	to	to	TO
cord-022594-fx044gcd	364	16	three	three	CD
cord-022594-fx044gcd	364	17	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	364	18	baseline	baseline	JJ
cord-022594-fx044gcd	364	19	cerebral	cerebral	JJ
cord-022594-fx044gcd	364	20	lesions	lesion	NNS
cord-022594-fx044gcd	364	21	had	have	VBD
cord-022594-fx044gcd	364	22	developed	develop	VBN
cord-022594-fx044gcd	364	23	MS	MS	NNP
cord-022594-fx044gcd	364	24	(	(	-LRB-
cord-022594-fx044gcd	364	25	13	13	CD
cord-022594-fx044gcd	364	26	of	of	IN
cord-022594-fx044gcd	364	27	24	24	CD
cord-022594-fx044gcd	364	28	)	)	-RRB-
cord-022594-fx044gcd	364	29	compared	compare	VBN
cord-022594-fx044gcd	364	30	with	with	IN
cord-022594-fx044gcd	364	31	the	the	DT
cord-022594-fx044gcd	364	32	majority	majority	NN
cord-022594-fx044gcd	364	33	of	of	IN
cord-022594-fx044gcd	364	34	cases	case	NNS
cord-022594-fx044gcd	364	35	presenting	present	VBG
cord-022594-fx044gcd	364	36	with	with	IN
cord-022594-fx044gcd	364	37	at	at	RB
cord-022594-fx044gcd	364	38	least	least	RBS
cord-022594-fx044gcd	364	39	four	four	CD
cord-022594-fx044gcd	364	40	baseline	baseline	JJ
cord-022594-fx044gcd	364	41	lesions	lesion	NNS
cord-022594-fx044gcd	364	42	(	(	-LRB-
cord-022594-fx044gcd	364	43	28	28	CD
cord-022594-fx044gcd	364	44	of	of	IN
cord-022594-fx044gcd	364	45	33	33	CD
cord-022594-fx044gcd	364	46	,	,	,
cord-022594-fx044gcd	364	47	85	85	CD
cord-022594-fx044gcd	364	48	%	%	NN
cord-022594-fx044gcd	364	49	)	)	-RRB-
cord-022594-fx044gcd	364	50	.	.	.
cord-022594-fx044gcd	365	1	After	after	IN
cord-022594-fx044gcd	365	2	10	10	CD
cord-022594-fx044gcd	365	3	years	year	NNS
cord-022594-fx044gcd	365	4	of	of	IN
cord-022594-fx044gcd	365	5	follow	follow	NN
cord-022594-fx044gcd	365	6	-	-	HYPH
cord-022594-fx044gcd	365	7	up	up	NN
cord-022594-fx044gcd	365	8	,	,	,
cord-022594-fx044gcd	365	9	the	the	DT
cord-022594-fx044gcd	365	10	majority	majority	NN
cord-022594-fx044gcd	365	11	of	of	IN
cord-022594-fx044gcd	365	12	patients	patient	NNS
cord-022594-fx044gcd	365	13	with	with	IN
cord-022594-fx044gcd	365	14	any	any	DT
cord-022594-fx044gcd	365	15	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	365	16	cerebral	cerebral	JJ
cord-022594-fx044gcd	365	17	lesions	lesion	NNS
cord-022594-fx044gcd	365	18	had	have	VBD
cord-022594-fx044gcd	365	19	developed	develop	VBN
cord-022594-fx044gcd	365	20	definite	definite	JJ
cord-022594-fx044gcd	365	21	MS	MS	NNP
cord-022594-fx044gcd	365	22	(	(	-LRB-
cord-022594-fx044gcd	365	23	45	45	CD
cord-022594-fx044gcd	365	24	of	of	IN
cord-022594-fx044gcd	365	25	54	54	CD
cord-022594-fx044gcd	365	26	,	,	,
cord-022594-fx044gcd	365	27	83	83	CD
cord-022594-fx044gcd	365	28	%	%	NN
cord-022594-fx044gcd	365	29	)	)	-RRB-
cord-022594-fx044gcd	365	30	.	.	.
cord-022594-fx044gcd	366	1	39	39	CD
cord-022594-fx044gcd	367	1	The	the	DT
cord-022594-fx044gcd	367	2	recently	recently	RB
cord-022594-fx044gcd	367	3	published	publish	VBN
cord-022594-fx044gcd	367	4	14-year	14-year	JJ
cord-022594-fx044gcd	367	5	follow	follow	NN
cord-022594-fx044gcd	367	6	-	-	HYPH
cord-022594-fx044gcd	367	7	up	up	NN
cord-022594-fx044gcd	367	8	data	datum	NNS
cord-022594-fx044gcd	367	9	on	on	IN
cord-022594-fx044gcd	367	10	this	this	DT
cord-022594-fx044gcd	367	11	group	group	NN
cord-022594-fx044gcd	367	12	of	of	IN
cord-022594-fx044gcd	367	13	patients	patient	NNS
cord-022594-fx044gcd	367	14	reveals	reveal	VBZ
cord-022594-fx044gcd	367	15	that	that	IN
cord-022594-fx044gcd	367	16	88	88	CD
cord-022594-fx044gcd	367	17	%	%	NN
cord-022594-fx044gcd	367	18	of	of	IN
cord-022594-fx044gcd	367	19	the	the	DT
cord-022594-fx044gcd	367	20	initially	initially	RB
cord-022594-fx044gcd	367	21	MRI	MRI	NNP
cord-022594-fx044gcd	367	22	positive	positive	JJ
cord-022594-fx044gcd	367	23	patients	patient	NNS
cord-022594-fx044gcd	367	24	developed	develop	VBD
cord-022594-fx044gcd	367	25	MS	MS	NNP
cord-022594-fx044gcd	367	26	versus	versus	IN
cord-022594-fx044gcd	367	27	19	19	CD
cord-022594-fx044gcd	367	28	%	%	NN
cord-022594-fx044gcd	367	29	of	of	IN
cord-022594-fx044gcd	367	30	the	the	DT
cord-022594-fx044gcd	367	31	MRI	MRI	NNP
cord-022594-fx044gcd	367	32	negative	negative	JJ
cord-022594-fx044gcd	367	33	subgroup	subgroup	NN
cord-022594-fx044gcd	367	34	.	.	.
cord-022594-fx044gcd	368	1	40	40	CD
cord-022594-fx044gcd	369	1	This	this	DT
cord-022594-fx044gcd	369	2	information	information	NN
cord-022594-fx044gcd	369	3	is	be	VBZ
cord-022594-fx044gcd	369	4	helpful	helpful	JJ
cord-022594-fx044gcd	369	5	for	for	IN
cord-022594-fx044gcd	369	6	treating	treat	VBG
cord-022594-fx044gcd	369	7	patients	patient	NNS
cord-022594-fx044gcd	369	8	in	in	IN
cord-022594-fx044gcd	369	9	the	the	DT
cord-022594-fx044gcd	369	10	setting	setting	NN
cord-022594-fx044gcd	369	11	of	of	IN
cord-022594-fx044gcd	369	12	CIS	CIS	NNP
cord-022594-fx044gcd	369	13	.	.	.
cord-022594-fx044gcd	370	1	DIFFERENTIAL	differential	JJ
cord-022594-fx044gcd	370	2	DIAGNOSIS	diagnosis	NN
cord-022594-fx044gcd	370	3	.	.	.
cord-022594-fx044gcd	371	1	Only	only	RB
cord-022594-fx044gcd	371	2	a	a	DT
cord-022594-fx044gcd	371	3	few	few	JJ
cord-022594-fx044gcd	371	4	diseases	disease	NNS
cord-022594-fx044gcd	371	5	cause	cause	VBP
cord-022594-fx044gcd	371	6	neurological	neurological	JJ
cord-022594-fx044gcd	371	7	deficits	deficit	NNS
cord-022594-fx044gcd	371	8	that	that	WDT
cord-022594-fx044gcd	371	9	regress	regress	VBP
cord-022594-fx044gcd	371	10	spontaneously	spontaneously	RB
cord-022594-fx044gcd	371	11	and	and	CC
cord-022594-fx044gcd	371	12	relapse	relapse	VB
cord-022594-fx044gcd	371	13	in	in	IN
cord-022594-fx044gcd	371	14	different	different	JJ
cord-022594-fx044gcd	371	15	areas	area	NNS
cord-022594-fx044gcd	371	16	of	of	IN
cord-022594-fx044gcd	371	17	the	the	DT
cord-022594-fx044gcd	371	18	CNS	CNS	NNP
cord-022594-fx044gcd	371	19	over	over	IN
cord-022594-fx044gcd	371	20	the	the	DT
cord-022594-fx044gcd	371	21	course	course	NN
cord-022594-fx044gcd	371	22	of	of	IN
cord-022594-fx044gcd	371	23	many	many	JJ
cord-022594-fx044gcd	371	24	years	year	NNS
cord-022594-fx044gcd	371	25	.	.	.
cord-022594-fx044gcd	372	1	However	however	RB
cord-022594-fx044gcd	372	2	,	,	,
cord-022594-fx044gcd	372	3	because	because	IN
cord-022594-fx044gcd	372	4	of	of	IN
cord-022594-fx044gcd	372	5	the	the	DT
cord-022594-fx044gcd	372	6	remarkable	remarkable	JJ
cord-022594-fx044gcd	372	7	heterogeneity	heterogeneity	NN
cord-022594-fx044gcd	372	8	of	of	IN
cord-022594-fx044gcd	372	9	MS	MS	NNP
cord-022594-fx044gcd	372	10	,	,	,
cord-022594-fx044gcd	372	11	many	many	JJ
cord-022594-fx044gcd	372	12	disorders	disorder	NNS
cord-022594-fx044gcd	372	13	may	may	MD
cord-022594-fx044gcd	372	14	resemble	resemble	VB
cord-022594-fx044gcd	372	15	MS	MS	NNP
cord-022594-fx044gcd	372	16	(	(	-LRB-
cord-022594-fx044gcd	372	17	Table	Table	NNP
cord-022594-fx044gcd	372	18	48	48	CD
cord-022594-fx044gcd	372	19	-	-	SYM
cord-022594-fx044gcd	372	20	3	3	CD
cord-022594-fx044gcd	372	21	)	)	-RRB-
cord-022594-fx044gcd	372	22	,	,	,
cord-022594-fx044gcd	372	23	especially	especially	RB
cord-022594-fx044gcd	372	24	in	in	IN
cord-022594-fx044gcd	372	25	the	the	DT
cord-022594-fx044gcd	372	26	first	first	JJ
cord-022594-fx044gcd	372	27	years	year	NNS
cord-022594-fx044gcd	372	28	of	of	IN
cord-022594-fx044gcd	372	29	active	active	JJ
cord-022594-fx044gcd	372	30	disease	disease	NN
cord-022594-fx044gcd	372	31	.	.	.
cord-022594-fx044gcd	373	1	Other	other	JJ
cord-022594-fx044gcd	373	2	primary	primary	JJ
cord-022594-fx044gcd	373	3	idiopathic	idiopathic	JJ
cord-022594-fx044gcd	373	4	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	373	5	demyelinating	demyelinate	VBG
cord-022594-fx044gcd	373	6	CNS	CNS	NNP
cord-022594-fx044gcd	373	7	disorders	disorder	NNS
cord-022594-fx044gcd	373	8	may	may	MD
cord-022594-fx044gcd	373	9	be	be	VB
cord-022594-fx044gcd	373	10	mistaken	mistake	VBN
cord-022594-fx044gcd	373	11	for	for	IN
cord-022594-fx044gcd	373	12	MS	MS	NNP
cord-022594-fx044gcd	373	13	.	.	.
cord-022594-fx044gcd	374	1	ADEM	ADEM	NNP
cord-022594-fx044gcd	374	2	usually	usually	RB
cord-022594-fx044gcd	374	3	causes	cause	VBZ
cord-022594-fx044gcd	374	4	monophasic	monophasic	JJ
cord-022594-fx044gcd	374	5	CNS	CNS	NNP
cord-022594-fx044gcd	374	6	demyelination	demyelination	NN
cord-022594-fx044gcd	374	7	.	.	.
cord-022594-fx044gcd	375	1	Although	although	IN
cord-022594-fx044gcd	375	2	it	-PRON-	PRP
cord-022594-fx044gcd	375	3	frequently	frequently	RB
cord-022594-fx044gcd	375	4	involves	involve	VBZ
cord-022594-fx044gcd	375	5	multifocal	multifocal	JJ
cord-022594-fx044gcd	375	6	areas	area	NNS
cord-022594-fx044gcd	375	7	of	of	IN
cord-022594-fx044gcd	375	8	white	white	JJ
cord-022594-fx044gcd	375	9	matter	matter	NN
cord-022594-fx044gcd	375	10	simultaneously	simultaneously	RB
cord-022594-fx044gcd	375	11	,	,	,
cord-022594-fx044gcd	375	12	ADEM	ADEM	NNP
cord-022594-fx044gcd	375	13	can	can	MD
cord-022594-fx044gcd	375	14	not	not	RB
cord-022594-fx044gcd	375	15	be	be	VB
cord-022594-fx044gcd	375	16	reliably	reliably	RB
cord-022594-fx044gcd	375	17	differentiated	differentiate	VBN
cord-022594-fx044gcd	375	18	from	from	IN
cord-022594-fx044gcd	375	19	the	the	DT
cord-022594-fx044gcd	375	20	initial	initial	JJ
cord-022594-fx044gcd	375	21	clinical	clinical	JJ
cord-022594-fx044gcd	375	22	episode	episode	NN
cord-022594-fx044gcd	375	23	of	of	IN
cord-022594-fx044gcd	375	24	MS	MS	NNP
cord-022594-fx044gcd	375	25	.	.	.
cord-022594-fx044gcd	376	1	Fulminant	Fulminant	NNP
cord-022594-fx044gcd	376	2	brain	brain	NN
cord-022594-fx044gcd	376	3	demyelination	demyelination	NN
cord-022594-fx044gcd	376	4	in	in	IN
cord-022594-fx044gcd	376	5	persons	person	NNS
cord-022594-fx044gcd	376	6	without	without	IN
cord-022594-fx044gcd	376	7	previous	previous	JJ
cord-022594-fx044gcd	376	8	symptoms	symptom	NNS
cord-022594-fx044gcd	376	9	of	of	IN
cord-022594-fx044gcd	376	10	MS	MS	NNP
cord-022594-fx044gcd	376	11	is	be	VBZ
cord-022594-fx044gcd	376	12	more	more	RBR
cord-022594-fx044gcd	376	13	likely	likely	JJ
cord-022594-fx044gcd	376	14	due	due	IN
cord-022594-fx044gcd	376	15	to	to	IN
cord-022594-fx044gcd	376	16	ADEM	ADEM	NNP
cord-022594-fx044gcd	376	17	or	or	CC
cord-022594-fx044gcd	376	18	other	other	JJ
cord-022594-fx044gcd	376	19	conditions	condition	NNS
cord-022594-fx044gcd	376	20	(	(	-LRB-
cord-022594-fx044gcd	376	21	Schilder	Schilder	NNP
cord-022594-fx044gcd	376	22	's	's	POS
cord-022594-fx044gcd	376	23	myelinoclastic	myelinoclastic	JJ
cord-022594-fx044gcd	376	24	diffuse	diffuse	JJ
cord-022594-fx044gcd	376	25	sclerosis	sclerosis	NN
cord-022594-fx044gcd	376	26	,	,	,
cord-022594-fx044gcd	376	27	Balo	Balo	NNP
cord-022594-fx044gcd	376	28	's	's	POS
cord-022594-fx044gcd	376	29	concentric	concentric	JJ
cord-022594-fx044gcd	376	30	sclerosis	sclerosis	NN
cord-022594-fx044gcd	376	31	,	,	,
cord-022594-fx044gcd	376	32	Marburg	Marburg	NNP
cord-022594-fx044gcd	376	33	's	's	POS
cord-022594-fx044gcd	376	34	variant	variant	NN
cord-022594-fx044gcd	376	35	of	of	IN
cord-022594-fx044gcd	376	36	MS	MS	NNP
cord-022594-fx044gcd	376	37	)	)	-RRB-
cord-022594-fx044gcd	376	38	.	.	.
cord-022594-fx044gcd	377	1	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	377	2	optica	optica	NN
cord-022594-fx044gcd	377	3	differs	differ	VBZ
cord-022594-fx044gcd	377	4	from	from	IN
cord-022594-fx044gcd	377	5	MS	MS	NNP
cord-022594-fx044gcd	377	6	primarily	primarily	RB
cord-022594-fx044gcd	377	7	in	in	IN
cord-022594-fx044gcd	377	8	the	the	DT
cord-022594-fx044gcd	377	9	topography	topography	NN
cord-022594-fx044gcd	377	10	and	and	CC
cord-022594-fx044gcd	377	11	intensity	intensity	NN
cord-022594-fx044gcd	377	12	of	of	IN
cord-022594-fx044gcd	377	13	the	the	DT
cord-022594-fx044gcd	377	14	lesions	lesion	NNS
cord-022594-fx044gcd	377	15	.	.	.
cord-022594-fx044gcd	378	1	Several	several	JJ
cord-022594-fx044gcd	378	2	systemic	systemic	JJ
cord-022594-fx044gcd	378	3	or	or	CC
cord-022594-fx044gcd	378	4	organ	organ	NN
cord-022594-fx044gcd	378	5	-	-	HYPH
cord-022594-fx044gcd	378	6	specific	specific	JJ
cord-022594-fx044gcd	378	7	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	378	8	conditions	condition	NNS
cord-022594-fx044gcd	378	9	can	can	MD
cord-022594-fx044gcd	378	10	involve	involve	VB
cord-022594-fx044gcd	378	11	the	the	DT
cord-022594-fx044gcd	378	12	CNS	CNS	NNP
cord-022594-fx044gcd	378	13	white	white	JJ
cord-022594-fx044gcd	378	14	matter	matter	NN
cord-022594-fx044gcd	378	15	.	.	.
cord-022594-fx044gcd	379	1	ON	ON	NNP
cord-022594-fx044gcd	379	2	,	,	,
cord-022594-fx044gcd	379	3	myelitis	myelitis	NNP
cord-022594-fx044gcd	379	4	,	,	,
cord-022594-fx044gcd	379	5	and	and	CC
cord-022594-fx044gcd	379	6	other	other	JJ
cord-022594-fx044gcd	379	7	syndromes	syndrome	NNS
cord-022594-fx044gcd	379	8	sometimes	sometimes	RB
cord-022594-fx044gcd	379	9	occur	occur	VBP
cord-022594-fx044gcd	379	10	with	with	IN
cord-022594-fx044gcd	379	11	systemic	systemic	JJ
cord-022594-fx044gcd	379	12	lupus	lupus	NN
cord-022594-fx044gcd	379	13	erythematosus	erythematosus	NN
cord-022594-fx044gcd	379	14	.	.	.
cord-022594-fx044gcd	380	1	Whether	whether	IN
cord-022594-fx044gcd	380	2	this	this	DT
cord-022594-fx044gcd	380	3	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	380	4	disease	disease	NN
cord-022594-fx044gcd	380	5	increases	increase	VBZ
cord-022594-fx044gcd	380	6	the	the	DT
cord-022594-fx044gcd	380	7	risk	risk	NN
cord-022594-fx044gcd	380	8	of	of	IN
cord-022594-fx044gcd	380	9	developing	develop	VBG
cord-022594-fx044gcd	380	10	MS	MS	NNP
cord-022594-fx044gcd	380	11	or	or	CC
cord-022594-fx044gcd	380	12	causes	cause	VBZ
cord-022594-fx044gcd	380	13	similar	similar	JJ
cord-022594-fx044gcd	380	14	syndromes	syndrome	NNS
cord-022594-fx044gcd	380	15	by	by	IN
cord-022594-fx044gcd	380	16	a	a	DT
cord-022594-fx044gcd	380	17	different	different	JJ
cord-022594-fx044gcd	380	18	pathological	pathological	JJ
cord-022594-fx044gcd	380	19	process	process	NN
cord-022594-fx044gcd	380	20	is	be	VBZ
cord-022594-fx044gcd	380	21	unknown	unknown	JJ
cord-022594-fx044gcd	380	22	.	.	.
cord-022594-fx044gcd	381	1	Sarcoidosis	sarcoidosi	NNS
cord-022594-fx044gcd	381	2	can	can	MD
cord-022594-fx044gcd	381	3	affect	affect	VB
cord-022594-fx044gcd	381	4	the	the	DT
cord-022594-fx044gcd	381	5	nervous	nervous	JJ
cord-022594-fx044gcd	381	6	system	system	NN
cord-022594-fx044gcd	381	7	in	in	IN
cord-022594-fx044gcd	381	8	several	several	JJ
cord-022594-fx044gcd	381	9	ways	way	NNS
cord-022594-fx044gcd	381	10	,	,	,
cord-022594-fx044gcd	381	11	including	include	VBG
cord-022594-fx044gcd	381	12	multifocal	multifocal	JJ
cord-022594-fx044gcd	381	13	,	,	,
cord-022594-fx044gcd	381	14	corticosteroid	corticosteroid	NN
cord-022594-fx044gcd	381	15	-	-	HYPH
cord-022594-fx044gcd	381	16	responsive	responsive	JJ
cord-022594-fx044gcd	381	17	white	white	JJ
cord-022594-fx044gcd	381	18	matter	matter	NN
cord-022594-fx044gcd	381	19	lesions	lesion	NNS
cord-022594-fx044gcd	381	20	.	.	.
cord-022594-fx044gcd	382	1	Sjögren	Sjögren	NNP
cord-022594-fx044gcd	382	2	's	's	POS
cord-022594-fx044gcd	382	3	syndrome	syndrome	NN
cord-022594-fx044gcd	382	4	sometimes	sometimes	RB
cord-022594-fx044gcd	382	5	occurs	occur	VBZ
cord-022594-fx044gcd	382	6	with	with	IN
cord-022594-fx044gcd	382	7	MS	MS	NNP
cord-022594-fx044gcd	382	8	,	,	,
cord-022594-fx044gcd	382	9	but	but	CC
cord-022594-fx044gcd	382	10	this	this	DT
cord-022594-fx044gcd	382	11	may	may	MD
cord-022594-fx044gcd	382	12	only	only	RB
cord-022594-fx044gcd	382	13	represent	represent	VB
cord-022594-fx044gcd	382	14	a	a	DT
cord-022594-fx044gcd	382	15	chance	chance	NN
cord-022594-fx044gcd	382	16	association	association	NN
cord-022594-fx044gcd	382	17	.	.	.
cord-022594-fx044gcd	383	1	Neuro	Neuro	NNP
cord-022594-fx044gcd	383	2	-	-	HYPH
cord-022594-fx044gcd	383	3	Behçet	Behçet	NNP
cord-022594-fx044gcd	383	4	's	's	POS
cord-022594-fx044gcd	383	5	disease	disease	NN
cord-022594-fx044gcd	383	6	has	have	VBZ
cord-022594-fx044gcd	383	7	a	a	DT
cord-022594-fx044gcd	383	8	predilection	predilection	NN
cord-022594-fx044gcd	383	9	for	for	IN
cord-022594-fx044gcd	383	10	the	the	DT
cord-022594-fx044gcd	383	11	brain	brain	NN
cord-022594-fx044gcd	383	12	stem	stem	NN
cord-022594-fx044gcd	383	13	.	.	.
cord-022594-fx044gcd	384	1	Occasionally	occasionally	RB
cord-022594-fx044gcd	384	2	,	,	,
cord-022594-fx044gcd	384	3	isolated	isolate	VBN
cord-022594-fx044gcd	384	4	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	384	5	syndromes	syndrome	NNS
cord-022594-fx044gcd	384	6	are	be	VBP
cord-022594-fx044gcd	384	7	associated	associate	VBN
cord-022594-fx044gcd	384	8	with	with	IN
cord-022594-fx044gcd	384	9	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	384	10	bowel	bowel	NN
cord-022594-fx044gcd	384	11	disease	disease	NN
cord-022594-fx044gcd	384	12	.	.	.
cord-022594-fx044gcd	385	1	A	a	DT
cord-022594-fx044gcd	385	2	wide	wide	JJ
cord-022594-fx044gcd	385	3	variety	variety	NN
cord-022594-fx044gcd	385	4	of	of	IN
cord-022594-fx044gcd	385	5	vasculitic	vasculitic	JJ
cord-022594-fx044gcd	385	6	syndromes	syndrome	NNS
cord-022594-fx044gcd	385	7	(	(	-LRB-
cord-022594-fx044gcd	385	8	e.g.	e.g.	RB
cord-022594-fx044gcd	385	9	,	,	,
cord-022594-fx044gcd	385	10	primary	primary	JJ
cord-022594-fx044gcd	385	11	angiitis	angiitis	NN
cord-022594-fx044gcd	385	12	of	of	IN
cord-022594-fx044gcd	385	13	the	the	DT
cord-022594-fx044gcd	385	14	CNS	CNS	NNP
cord-022594-fx044gcd	385	15	,	,	,
cord-022594-fx044gcd	385	16	periarteritis	periarteritis	NNP
cord-022594-fx044gcd	385	17	nodosa	nodosa	NNP
cord-022594-fx044gcd	385	18	,	,	,
cord-022594-fx044gcd	385	19	Wegener	Wegener	NNP
cord-022594-fx044gcd	385	20	's	's	POS
cord-022594-fx044gcd	385	21	granulomatous	granulomatous	JJ
cord-022594-fx044gcd	385	22	angiitis	angiitis	RB
cord-022594-fx044gcd	385	23	,	,	,
cord-022594-fx044gcd	385	24	vasculitis	vasculitis	NN
cord-022594-fx044gcd	385	25	associated	associate	VBN
cord-022594-fx044gcd	385	26	with	with	IN
cord-022594-fx044gcd	385	27	rheumatoid	rheumatoid	NN
cord-022594-fx044gcd	385	28	arthritis	arthritis	NN
cord-022594-fx044gcd	385	29	,	,	,
cord-022594-fx044gcd	385	30	Susac	Susac	NNP
cord-022594-fx044gcd	385	31	's	's	POS
cord-022594-fx044gcd	385	32	syndrome	syndrome	NN
cord-022594-fx044gcd	385	33	,	,	,
cord-022594-fx044gcd	385	34	Eales'disease	Eales'disease	NNP
cord-022594-fx044gcd	385	35	)	)	-RRB-
cord-022594-fx044gcd	385	36	may	may	MD
cord-022594-fx044gcd	385	37	mimic	mimic	VB
cord-022594-fx044gcd	385	38	MS	MS	NNP
cord-022594-fx044gcd	385	39	.	.	.
cord-022594-fx044gcd	386	1	However	however	RB
cord-022594-fx044gcd	386	2	,	,	,
cord-022594-fx044gcd	386	3	these	these	DT
cord-022594-fx044gcd	386	4	syndromes	syndrome	NNS
cord-022594-fx044gcd	386	5	can	can	MD
cord-022594-fx044gcd	386	6	usually	usually	RB
cord-022594-fx044gcd	386	7	be	be	VB
cord-022594-fx044gcd	386	8	distinguished	distinguish	VBN
cord-022594-fx044gcd	386	9	by	by	IN
cord-022594-fx044gcd	386	10	involvement	involvement	NN
cord-022594-fx044gcd	386	11	of	of	IN
cord-022594-fx044gcd	386	12	the	the	DT
cord-022594-fx044gcd	386	13	cortex	cortex	NN
cord-022594-fx044gcd	386	14	,	,	,
cord-022594-fx044gcd	386	15	seizures	seizure	NNS
cord-022594-fx044gcd	386	16	,	,	,
cord-022594-fx044gcd	386	17	early	early	JJ
cord-022594-fx044gcd	386	18	dementia	dementia	NN
cord-022594-fx044gcd	386	19	,	,	,
cord-022594-fx044gcd	386	20	personality	personality	NN
cord-022594-fx044gcd	386	21	changes	change	NNS
cord-022594-fx044gcd	386	22	,	,	,
cord-022594-fx044gcd	386	23	psychosis	psychosis	NN
cord-022594-fx044gcd	386	24	,	,	,
cord-022594-fx044gcd	386	25	infarcts	infarct	NNS
cord-022594-fx044gcd	386	26	involving	involve	VBG
cord-022594-fx044gcd	386	27	large	large	JJ
cord-022594-fx044gcd	386	28	vessel	vessel	NN
cord-022594-fx044gcd	386	29	territories	territory	NNS
cord-022594-fx044gcd	386	30	on	on	IN
cord-022594-fx044gcd	386	31	MRI	MRI	NNP
cord-022594-fx044gcd	386	32	,	,	,
cord-022594-fx044gcd	386	33	and	and	CC
cord-022594-fx044gcd	386	34	lack	lack	NN
cord-022594-fx044gcd	386	35	of	of	IN
cord-022594-fx044gcd	386	36	improvement	improvement	NN
cord-022594-fx044gcd	386	37	.	.	.
cord-022594-fx044gcd	387	1	Findings	finding	NNS
cord-022594-fx044gcd	387	2	characteristic	characteristic	JJ
cord-022594-fx044gcd	387	3	to	to	IN
cord-022594-fx044gcd	387	4	the	the	DT
cord-022594-fx044gcd	387	5	particular	particular	JJ
cord-022594-fx044gcd	387	6	vasculitis	vasculitis	NN
cord-022594-fx044gcd	387	7	(	(	-LRB-
cord-022594-fx044gcd	387	8	uveitis	uveitis	NN
cord-022594-fx044gcd	387	9	and	and	CC
cord-022594-fx044gcd	387	10	vitreal	vitreal	NN
cord-022594-fx044gcd	387	11	hemorrhage	hemorrhage	NN
cord-022594-fx044gcd	387	12	in	in	IN
cord-022594-fx044gcd	387	13	Eales	Eales	NNP
cord-022594-fx044gcd	387	14	'	'	POS
cord-022594-fx044gcd	387	15	disease	disease	NN
cord-022594-fx044gcd	387	16	,	,	,
cord-022594-fx044gcd	387	17	retinal	retinal	JJ
cord-022594-fx044gcd	387	18	and	and	CC
cord-022594-fx044gcd	387	19	cochlear	cochlear	JJ
cord-022594-fx044gcd	387	20	involvement	involvement	NN
cord-022594-fx044gcd	387	21	in	in	IN
cord-022594-fx044gcd	387	22	Susac	Susac	NNP
cord-022594-fx044gcd	387	23	's	's	POS
cord-022594-fx044gcd	387	24	syndrome	syndrome	NN
cord-022594-fx044gcd	387	25	,	,	,
cord-022594-fx044gcd	387	26	upper	upper	JJ
cord-022594-fx044gcd	387	27	and	and	CC
cord-022594-fx044gcd	387	28	lower	low	JJR
cord-022594-fx044gcd	387	29	respiratory	respiratory	JJ
cord-022594-fx044gcd	387	30	tract	tract	NN
cord-022594-fx044gcd	387	31	involvement	involvement	NN
cord-022594-fx044gcd	387	32	in	in	IN
cord-022594-fx044gcd	387	33	Wegener	Wegener	NNP
cord-022594-fx044gcd	387	34	's	's	POS
cord-022594-fx044gcd	387	35	granulomatosis	granulomatosis	NN
cord-022594-fx044gcd	387	36	)	)	-RRB-
cord-022594-fx044gcd	387	37	also	also	RB
cord-022594-fx044gcd	387	38	aid	aid	VB
cord-022594-fx044gcd	387	39	in	in	IN
cord-022594-fx044gcd	387	40	the	the	DT
cord-022594-fx044gcd	387	41	correct	correct	JJ
cord-022594-fx044gcd	387	42	diagnosis	diagnosis	NN
cord-022594-fx044gcd	387	43	.	.	.
cord-022594-fx044gcd	388	1	A	a	DT
cord-022594-fx044gcd	388	2	few	few	JJ
cord-022594-fx044gcd	388	3	infections	infection	NNS
cord-022594-fx044gcd	388	4	must	must	MD
cord-022594-fx044gcd	388	5	also	also	RB
cord-022594-fx044gcd	388	6	be	be	VB
cord-022594-fx044gcd	388	7	considered	consider	VBN
cord-022594-fx044gcd	388	8	in	in	IN
cord-022594-fx044gcd	388	9	the	the	DT
cord-022594-fx044gcd	388	10	differential	differential	JJ
cord-022594-fx044gcd	388	11	diagnosis	diagnosis	NN
cord-022594-fx044gcd	388	12	of	of	IN
cord-022594-fx044gcd	388	13	MS	MS	NNP
cord-022594-fx044gcd	388	14	.	.	.
cord-022594-fx044gcd	389	1	Both	both	DT
cord-022594-fx044gcd	389	2	Lyme	Lyme	NNP
cord-022594-fx044gcd	389	3	disease	disease	NN
cord-022594-fx044gcd	389	4	and	and	CC
cord-022594-fx044gcd	389	5	syphilis	syphili	NNS
cord-022594-fx044gcd	389	6	may	may	MD
cord-022594-fx044gcd	389	7	cause	cause	VB
cord-022594-fx044gcd	389	8	multifocal	multifocal	JJ
cord-022594-fx044gcd	389	9	white	white	JJ
cord-022594-fx044gcd	389	10	matter	matter	NN
cord-022594-fx044gcd	389	11	lesions	lesion	NNS
cord-022594-fx044gcd	389	12	.	.	.
cord-022594-fx044gcd	390	1	HTLV-1	HTLV-1	NNP
cord-022594-fx044gcd	390	2	causes	cause	VBZ
cord-022594-fx044gcd	390	3	a	a	DT
cord-022594-fx044gcd	390	4	chronic	chronic	JJ
cord-022594-fx044gcd	390	5	progressive	progressive	JJ
cord-022594-fx044gcd	390	6	myelopathy	myelopathy	NN
cord-022594-fx044gcd	390	7	(	(	-LRB-
cord-022594-fx044gcd	390	8	HTLV-1-associated	htlv-1-associate	VBN
cord-022594-fx044gcd	390	9	myelopathy	myelopathy	NN
cord-022594-fx044gcd	390	10	/	/	SYM
cord-022594-fx044gcd	390	11	tropical	tropical	JJ
cord-022594-fx044gcd	390	12	spastic	spastic	JJ
cord-022594-fx044gcd	390	13	paraparesis	paraparesis	NN
cord-022594-fx044gcd	390	14	)	)	-RRB-
cord-022594-fx044gcd	390	15	.	.	.
cord-022594-fx044gcd	391	1	Acute	acute	JJ
cord-022594-fx044gcd	391	2	or	or	CC
cord-022594-fx044gcd	391	3	recurrent	recurrent	JJ
cord-022594-fx044gcd	391	4	myelitis	myelitis	NN
cord-022594-fx044gcd	391	5	can	can	MD
cord-022594-fx044gcd	391	6	be	be	VB
cord-022594-fx044gcd	391	7	caused	cause	VBN
cord-022594-fx044gcd	391	8	by	by	IN
cord-022594-fx044gcd	391	9	VZV	VZV	NNP
cord-022594-fx044gcd	391	10	.	.	.
cord-022594-fx044gcd	392	1	Progressive	progressive	JJ
cord-022594-fx044gcd	392	2	multifocal	multifocal	JJ
cord-022594-fx044gcd	392	3	leukoencephalopathy	leukoencephalopathy	NNS
cord-022594-fx044gcd	392	4	and	and	CC
cord-022594-fx044gcd	392	5	Toxoplasma	toxoplasma	NN
cord-022594-fx044gcd	392	6	abscesses	abscess	NNS
cord-022594-fx044gcd	392	7	should	should	MD
cord-022594-fx044gcd	392	8	be	be	VB
cord-022594-fx044gcd	392	9	considered	consider	VBN
cord-022594-fx044gcd	392	10	in	in	IN
cord-022594-fx044gcd	392	11	immunocompromised	immunocompromised	JJ
cord-022594-fx044gcd	392	12	patients	patient	NNS
cord-022594-fx044gcd	392	13	with	with	IN
cord-022594-fx044gcd	392	14	progressive	progressive	JJ
cord-022594-fx044gcd	392	15	neurological	neurological	JJ
cord-022594-fx044gcd	392	16	decline	decline	NN
cord-022594-fx044gcd	392	17	.	.	.
cord-022594-fx044gcd	393	1	Bacterial	bacterial	JJ
cord-022594-fx044gcd	393	2	endocarditis	endocarditis	NN
cord-022594-fx044gcd	393	3	with	with	IN
cord-022594-fx044gcd	393	4	brain	brain	NN
cord-022594-fx044gcd	393	5	abscess	abscess	NN
cord-022594-fx044gcd	393	6	formation	formation	NN
cord-022594-fx044gcd	393	7	,	,	,
cord-022594-fx044gcd	393	8	subacute	subacute	JJ
cord-022594-fx044gcd	393	9	sclerosing	sclerosing	NN
cord-022594-fx044gcd	393	10	panencephalitis	panencephalitis	NN
cord-022594-fx044gcd	393	11	,	,	,
cord-022594-fx044gcd	393	12	or	or	CC
cord-022594-fx044gcd	393	13	chronic	chronic	JJ
cord-022594-fx044gcd	393	14	rubella	rubella	NN
cord-022594-fx044gcd	393	15	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	393	16	may	may	MD
cord-022594-fx044gcd	393	17	need	need	VB
cord-022594-fx044gcd	393	18	to	to	TO
cord-022594-fx044gcd	393	19	be	be	VB
cord-022594-fx044gcd	393	20	considered	consider	VBN
cord-022594-fx044gcd	393	21	in	in	IN
cord-022594-fx044gcd	393	22	the	the	DT
cord-022594-fx044gcd	393	23	appropriate	appropriate	JJ
cord-022594-fx044gcd	393	24	circumstances	circumstance	NNS
cord-022594-fx044gcd	393	25	.	.	.
cord-022594-fx044gcd	394	1	Cerebrovascular	cerebrovascular	JJ
cord-022594-fx044gcd	394	2	disease	disease	NN
cord-022594-fx044gcd	394	3	is	be	VBZ
cord-022594-fx044gcd	394	4	only	only	RB
cord-022594-fx044gcd	394	5	rarely	rarely	RB
cord-022594-fx044gcd	394	6	mistaken	mistake	VBN
cord-022594-fx044gcd	394	7	for	for	IN
cord-022594-fx044gcd	394	8	MS	MS	NNP
cord-022594-fx044gcd	394	9	.	.	.
cord-022594-fx044gcd	395	1	Occasionally	occasionally	RB
cord-022594-fx044gcd	395	2	,	,	,
cord-022594-fx044gcd	395	3	an	an	DT
cord-022594-fx044gcd	395	4	MS	MS	NNP
cord-022594-fx044gcd	395	5	relapse	relapse	NN
cord-022594-fx044gcd	395	6	has	have	VBZ
cord-022594-fx044gcd	395	7	an	an	DT
cord-022594-fx044gcd	395	8	abrupt	abrupt	JJ
cord-022594-fx044gcd	395	9	onset	onset	NN
cord-022594-fx044gcd	395	10	that	that	WDT
cord-022594-fx044gcd	395	11	may	may	MD
cord-022594-fx044gcd	395	12	mimic	mimic	VB
cord-022594-fx044gcd	395	13	an	an	DT
cord-022594-fx044gcd	395	14	infarct	infarct	NN
cord-022594-fx044gcd	395	15	,	,	,
cord-022594-fx044gcd	395	16	especially	especially	RB
cord-022594-fx044gcd	395	17	in	in	IN
cord-022594-fx044gcd	395	18	those	those	DT
cord-022594-fx044gcd	395	19	not	not	RB
cord-022594-fx044gcd	395	20	previously	previously	RB
cord-022594-fx044gcd	395	21	diagnosed	diagnose	VBN
cord-022594-fx044gcd	395	22	with	with	IN
cord-022594-fx044gcd	395	23	MS	MS	NNP
cord-022594-fx044gcd	395	24	.	.	.
cord-022594-fx044gcd	396	1	The	the	DT
cord-022594-fx044gcd	396	2	usual	usual	JJ
cord-022594-fx044gcd	396	3	circumstance	circumstance	NN
cord-022594-fx044gcd	396	4	is	be	VBZ
cord-022594-fx044gcd	396	5	that	that	DT
cord-022594-fx044gcd	396	6	of	of	IN
cord-022594-fx044gcd	396	7	a	a	DT
cord-022594-fx044gcd	396	8	hemisensory	hemisensory	NN
cord-022594-fx044gcd	396	9	or	or	CC
cord-022594-fx044gcd	396	10	hemimotor	hemimotor	NN
cord-022594-fx044gcd	396	11	deficit	deficit	NN
cord-022594-fx044gcd	396	12	imitating	imitate	VBG
cord-022594-fx044gcd	396	13	a	a	DT
cord-022594-fx044gcd	396	14	lacunar	lacunar	NNP
cord-022594-fx044gcd	396	15	infarct	infarct	NN
cord-022594-fx044gcd	396	16	.	.	.
cord-022594-fx044gcd	397	1	Disorders	disorder	NNS
cord-022594-fx044gcd	397	2	with	with	IN
cord-022594-fx044gcd	397	3	multiple	multiple	JJ
cord-022594-fx044gcd	397	4	cerebral	cerebral	JJ
cord-022594-fx044gcd	397	5	infarcts	infarct	NNS
cord-022594-fx044gcd	397	6	(	(	-LRB-
cord-022594-fx044gcd	397	7	emboli	emboli	JJR
cord-022594-fx044gcd	397	8	,	,	,
cord-022594-fx044gcd	397	9	hypercoagulable	hypercoagulable	JJ
cord-022594-fx044gcd	397	10	states	state	NNS
cord-022594-fx044gcd	397	11	,	,	,
cord-022594-fx044gcd	397	12	Sneddon	Sneddon	NNP
cord-022594-fx044gcd	397	13	's	's	POS
cord-022594-fx044gcd	397	14	syndrome	syndrome	NN
cord-022594-fx044gcd	397	15	,	,	,
cord-022594-fx044gcd	397	16	CADASIL	CADASIL	NNP
cord-022594-fx044gcd	397	17	,	,	,
cord-022594-fx044gcd	397	18	vasculitis	vasculitis	NN
cord-022594-fx044gcd	397	19	)	)	-RRB-
cord-022594-fx044gcd	397	20	may	may	MD
cord-022594-fx044gcd	397	21	produce	produce	VB
cord-022594-fx044gcd	397	22	an	an	DT
cord-022594-fx044gcd	397	23	MRI	MRI	NNP
cord-022594-fx044gcd	397	24	appearance	appearance	NN
cord-022594-fx044gcd	397	25	and	and	CC
cord-022594-fx044gcd	397	26	course	course	NN
cord-022594-fx044gcd	397	27	resembling	resemble	VBG
cord-022594-fx044gcd	397	28	MS	MS	NNP
cord-022594-fx044gcd	397	29	.	.	.
cord-022594-fx044gcd	398	1	Vascular	vascular	JJ
cord-022594-fx044gcd	398	2	malformations	malformation	NNS
cord-022594-fx044gcd	398	3	may	may	MD
cord-022594-fx044gcd	398	4	also	also	RB
cord-022594-fx044gcd	398	5	produce	produce	VB
cord-022594-fx044gcd	398	6	symptoms	symptom	NNS
cord-022594-fx044gcd	398	7	similar	similar	JJ
cord-022594-fx044gcd	398	8	to	to	IN
cord-022594-fx044gcd	398	9	MS	MS	NNP
cord-022594-fx044gcd	398	10	.	.	.
cord-022594-fx044gcd	399	1	Additional	additional	JJ
cord-022594-fx044gcd	399	2	neurological	neurological	JJ
cord-022594-fx044gcd	399	3	illnesses	illness	NNS
cord-022594-fx044gcd	399	4	capable	capable	JJ
cord-022594-fx044gcd	399	5	of	of	IN
cord-022594-fx044gcd	399	6	producing	produce	VBG
cord-022594-fx044gcd	399	7	multifocal	multifocal	JJ
cord-022594-fx044gcd	399	8	lesions	lesion	NNS
cord-022594-fx044gcd	399	9	rarely	rarely	RB
cord-022594-fx044gcd	399	10	mimic	mimic	VBP
cord-022594-fx044gcd	399	11	MS	MS	NNP
cord-022594-fx044gcd	399	12	.	.	.
cord-022594-fx044gcd	400	1	Metastatic	metastatic	JJ
cord-022594-fx044gcd	400	2	tumors	tumor	NNS
cord-022594-fx044gcd	400	3	and	and	CC
cord-022594-fx044gcd	400	4	multifocal	multifocal	JJ
cord-022594-fx044gcd	400	5	gliomas	glioma	NNS
cord-022594-fx044gcd	400	6	are	be	VBP
cord-022594-fx044gcd	400	7	often	often	RB
cord-022594-fx044gcd	400	8	cited	cite	VBN
cord-022594-fx044gcd	400	9	examples	example	NNS
cord-022594-fx044gcd	400	10	,	,	,
cord-022594-fx044gcd	400	11	but	but	CC
cord-022594-fx044gcd	400	12	rarely	rarely	RB
cord-022594-fx044gcd	400	13	is	be	VBZ
cord-022594-fx044gcd	400	14	this	this	DT
cord-022594-fx044gcd	400	15	distinction	distinction	NN
cord-022594-fx044gcd	400	16	difficult	difficult	JJ
cord-022594-fx044gcd	400	17	for	for	IN
cord-022594-fx044gcd	400	18	an	an	DT
cord-022594-fx044gcd	400	19	experienced	experienced	JJ
cord-022594-fx044gcd	400	20	clinician	clinician	NN
cord-022594-fx044gcd	400	21	.	.	.
cord-022594-fx044gcd	401	1	Lymphoma	Lymphoma	NNP
cord-022594-fx044gcd	401	2	more	more	RBR
cord-022594-fx044gcd	401	3	commonly	commonly	RB
cord-022594-fx044gcd	401	4	masquerades	masquerade	VBZ
cord-022594-fx044gcd	401	5	as	as	IN
cord-022594-fx044gcd	401	6	MS	MS	NNP
cord-022594-fx044gcd	402	1	because	because	IN
cord-022594-fx044gcd	402	2	the	the	DT
cord-022594-fx044gcd	402	3	lesions	lesion	NNS
cord-022594-fx044gcd	402	4	may	may	MD
cord-022594-fx044gcd	402	5	involve	involve	VB
cord-022594-fx044gcd	402	6	the	the	DT
cord-022594-fx044gcd	402	7	white	white	JJ
cord-022594-fx044gcd	402	8	matter	matter	NN
cord-022594-fx044gcd	402	9	,	,	,
cord-022594-fx044gcd	402	10	may	may	MD
cord-022594-fx044gcd	402	11	be	be	VB
cord-022594-fx044gcd	402	12	multifocal	multifocal	JJ
cord-022594-fx044gcd	402	13	,	,	,
cord-022594-fx044gcd	402	14	and	and	CC
cord-022594-fx044gcd	402	15	are	be	VBP
cord-022594-fx044gcd	402	16	corticosteroid	corticosteroid	NN
cord-022594-fx044gcd	402	17	responsive	responsive	JJ
cord-022594-fx044gcd	402	18	.	.	.
cord-022594-fx044gcd	403	1	In	in	IN
cord-022594-fx044gcd	403	2	addition	addition	NN
cord-022594-fx044gcd	403	3	,	,	,
cord-022594-fx044gcd	403	4	demyelination	demyelination	NN
cord-022594-fx044gcd	403	5	sometimes	sometimes	RB
cord-022594-fx044gcd	403	6	presents	present	VBZ
cord-022594-fx044gcd	403	7	as	as	IN
cord-022594-fx044gcd	403	8	one	one	CD
cord-022594-fx044gcd	403	9	(	(	-LRB-
cord-022594-fx044gcd	403	10	or	or	CC
cord-022594-fx044gcd	403	11	a	a	DT
cord-022594-fx044gcd	403	12	few	few	JJ
cord-022594-fx044gcd	403	13	)	)	-RRB-
cord-022594-fx044gcd	403	14	mass	mass	NN
cord-022594-fx044gcd	403	15	lesion(s	lesion(s	NNP
cord-022594-fx044gcd	403	16	)	)	-RRB-
cord-022594-fx044gcd	403	17	.	.	.
cord-022594-fx044gcd	404	1	In	in	IN
cord-022594-fx044gcd	404	2	this	this	DT
cord-022594-fx044gcd	404	3	situation	situation	NN
cord-022594-fx044gcd	404	4	,	,	,
cord-022594-fx044gcd	404	5	biopsy	biopsy	NN
cord-022594-fx044gcd	404	6	may	may	MD
cord-022594-fx044gcd	404	7	be	be	VB
cord-022594-fx044gcd	404	8	needed	need	VBN
cord-022594-fx044gcd	404	9	for	for	IN
cord-022594-fx044gcd	404	10	diagnosis	diagnosis	NN
cord-022594-fx044gcd	404	11	.	.	.
cord-022594-fx044gcd	405	1	Neoplasms	neoplasm	NNS
cord-022594-fx044gcd	405	2	can	can	MD
cord-022594-fx044gcd	405	3	cause	cause	VB
cord-022594-fx044gcd	405	4	paraneoplastic	paraneoplastic	JJ
cord-022594-fx044gcd	405	5	syndromes	syndrome	NNS
cord-022594-fx044gcd	405	6	that	that	WDT
cord-022594-fx044gcd	405	7	may	may	MD
cord-022594-fx044gcd	405	8	be	be	VB
cord-022594-fx044gcd	405	9	confused	confuse	VBN
cord-022594-fx044gcd	405	10	with	with	IN
cord-022594-fx044gcd	405	11	MS	MS	NNP
cord-022594-fx044gcd	405	12	.	.	.
cord-022594-fx044gcd	406	1	A	a	DT
cord-022594-fx044gcd	406	2	high	high	JJ
cord-022594-fx044gcd	406	3	index	index	NN
cord-022594-fx044gcd	406	4	of	of	IN
cord-022594-fx044gcd	406	5	suspicion	suspicion	NN
cord-022594-fx044gcd	406	6	must	must	MD
cord-022594-fx044gcd	406	7	be	be	VB
cord-022594-fx044gcd	406	8	kept	keep	VBN
cord-022594-fx044gcd	406	9	for	for	IN
cord-022594-fx044gcd	406	10	older	old	JJR
cord-022594-fx044gcd	406	11	age	age	NN
cord-022594-fx044gcd	406	12	at	at	IN
cord-022594-fx044gcd	406	13	presentation	presentation	NN
cord-022594-fx044gcd	406	14	,	,	,
cord-022594-fx044gcd	406	15	subacute	subacute	JJ
cord-022594-fx044gcd	406	16	ataxia	ataxia	NN
cord-022594-fx044gcd	406	17	,	,	,
cord-022594-fx044gcd	406	18	early	early	JJ
cord-022594-fx044gcd	406	19	dementia	dementia	NN
cord-022594-fx044gcd	406	20	,	,	,
cord-022594-fx044gcd	406	21	and	and	CC
cord-022594-fx044gcd	406	22	personality	personality	NN
cord-022594-fx044gcd	406	23	changes	change	NNS
cord-022594-fx044gcd	406	24	.	.	.
cord-022594-fx044gcd	407	1	A	a	DT
cord-022594-fx044gcd	407	2	few	few	JJ
cord-022594-fx044gcd	407	3	metabolic	metabolic	JJ
cord-022594-fx044gcd	407	4	disorders	disorder	NNS
cord-022594-fx044gcd	407	5	may	may	MD
cord-022594-fx044gcd	407	6	resemble	resemble	VB
cord-022594-fx044gcd	407	7	MS	MS	NNP
cord-022594-fx044gcd	407	8	,	,	,
cord-022594-fx044gcd	407	9	such	such	JJ
cord-022594-fx044gcd	407	10	as	as	IN
cord-022594-fx044gcd	407	11	vitamin	vitamin	NN
cord-022594-fx044gcd	407	12	B	b	NN
cord-022594-fx044gcd	407	13	12	12	CD
cord-022594-fx044gcd	407	14	deficiency	deficiency	NN
cord-022594-fx044gcd	407	15	,	,	,
cord-022594-fx044gcd	407	16	vitamin	vitamin	NN
cord-022594-fx044gcd	407	17	E	e	NN
cord-022594-fx044gcd	407	18	deficiency	deficiency	NN
cord-022594-fx044gcd	407	19	(	(	-LRB-
cord-022594-fx044gcd	407	20	seen	see	VBN
cord-022594-fx044gcd	407	21	in	in	IN
cord-022594-fx044gcd	407	22	Bassen	Bassen	NNP
cord-022594-fx044gcd	407	23	-	-	HYPH
cord-022594-fx044gcd	407	24	Kornzweig	Kornzweig	NNP
cord-022594-fx044gcd	407	25	syndrome	syndrome	NN
cord-022594-fx044gcd	407	26	,	,	,
cord-022594-fx044gcd	407	27	hypobetalipoproteinemia	hypobetalipoproteinemia	NN
cord-022594-fx044gcd	407	28	,	,	,
cord-022594-fx044gcd	407	29	and	and	CC
cord-022594-fx044gcd	407	30	Refsum	Refsum	NNP
cord-022594-fx044gcd	407	31	's	's	POS
cord-022594-fx044gcd	407	32	disease	disease	NN
cord-022594-fx044gcd	407	33	)	)	-RRB-
cord-022594-fx044gcd	407	34	,	,	,
cord-022594-fx044gcd	407	35	and	and	CC
cord-022594-fx044gcd	407	36	central	central	JJ
cord-022594-fx044gcd	407	37	pontine	pontine	NNP
cord-022594-fx044gcd	407	38	or	or	CC
cord-022594-fx044gcd	407	39	extrapontine	extrapontine	NNP
cord-022594-fx044gcd	407	40	myelinolysis	myelinolysis	NNP
cord-022594-fx044gcd	407	41	(	(	-LRB-
cord-022594-fx044gcd	407	42	Video	video	NN
cord-022594-fx044gcd	407	43	113	113	CD
cord-022594-fx044gcd	407	44	,	,	,
cord-022594-fx044gcd	407	45	Pontine	Pontine	NNP
cord-022594-fx044gcd	407	46	Myelinolysis	Myelinolysis	NNP
cord-022594-fx044gcd	407	47	)	)	-RRB-
cord-022594-fx044gcd	407	48	.	.	.
cord-022594-fx044gcd	408	1	Leukodystrophies	Leukodystrophies	NNP
cord-022594-fx044gcd	408	2	are	be	VBP
cord-022594-fx044gcd	408	3	usually	usually	RB
cord-022594-fx044gcd	408	4	not	not	RB
cord-022594-fx044gcd	408	5	difficult	difficult	JJ
cord-022594-fx044gcd	408	6	to	to	TO
cord-022594-fx044gcd	408	7	distinguish	distinguish	VB
cord-022594-fx044gcd	408	8	from	from	IN
cord-022594-fx044gcd	408	9	MS	MS	NNP
cord-022594-fx044gcd	408	10	.	.	.
cord-022594-fx044gcd	409	1	Krabbe	Krabbe	NNP
cord-022594-fx044gcd	409	2	's	's	POS
cord-022594-fx044gcd	409	3	disease	disease	NN
cord-022594-fx044gcd	409	4	(	(	-LRB-
cord-022594-fx044gcd	409	5	galactocerebroside	galactocerebroside	NN
cord-022594-fx044gcd	409	6	-	-	HYPH
cord-022594-fx044gcd	409	7	b	b	NN
cord-022594-fx044gcd	409	8	-	-	HYPH
cord-022594-fx044gcd	409	9	galactosidase	galactosidase	NN
cord-022594-fx044gcd	409	10	deficiency	deficiency	NN
cord-022594-fx044gcd	409	11	)	)	-RRB-
cord-022594-fx044gcd	409	12	,	,	,
cord-022594-fx044gcd	409	13	metachromatic	metachromatic	JJ
cord-022594-fx044gcd	409	14	leukodystrophy	leukodystrophy	NN
cord-022594-fx044gcd	409	15	(	(	-LRB-
cord-022594-fx044gcd	409	16	MLD	MLD	NNP
cord-022594-fx044gcd	409	17	;	;	:
cord-022594-fx044gcd	409	18	arylsulfatase	arylsulfatase	NNP
cord-022594-fx044gcd	409	19	A	a	DT
cord-022594-fx044gcd	409	20	deficiency	deficiency	NN
cord-022594-fx044gcd	409	21	)	)	-RRB-
cord-022594-fx044gcd	409	22	,	,	,
cord-022594-fx044gcd	409	23	and	and	CC
cord-022594-fx044gcd	409	24	the	the	DT
cord-022594-fx044gcd	409	25	usual	usual	JJ
cord-022594-fx044gcd	409	26	adult	adult	NN
cord-022594-fx044gcd	409	27	form	form	NN
cord-022594-fx044gcd	409	28	of	of	IN
cord-022594-fx044gcd	409	29	adrenoleukodystrophy	adrenoleukodystrophy	NN
cord-022594-fx044gcd	409	30	(	(	-LRB-
cord-022594-fx044gcd	409	31	ALD	ALD	NNP
cord-022594-fx044gcd	409	32	)	)	-RRB-
cord-022594-fx044gcd	409	33	and	and	CC
cord-022594-fx044gcd	409	34	adrenomyeloneuropathy	adrenomyeloneuropathy	NNP
cord-022594-fx044gcd	409	35	(	(	-LRB-
cord-022594-fx044gcd	409	36	AMN	AMN	NNP
cord-022594-fx044gcd	409	37	)	)	-RRB-
cord-022594-fx044gcd	409	38	exhibit	exhibit	NN
cord-022594-fx044gcd	409	39	both	both	DT
cord-022594-fx044gcd	409	40	central	central	JJ
cord-022594-fx044gcd	409	41	and	and	CC
cord-022594-fx044gcd	409	42	peripheral	peripheral	JJ
cord-022594-fx044gcd	409	43	dysmyelination	dysmyelination	NN
cord-022594-fx044gcd	409	44	.	.	.
cord-022594-fx044gcd	410	1	Blood	blood	NN
cord-022594-fx044gcd	410	2	leukocyte	leukocyte	NN
cord-022594-fx044gcd	410	3	or	or	CC
cord-022594-fx044gcd	410	4	fibroblast	fibroblast	NN
cord-022594-fx044gcd	410	5	culture	culture	NN
cord-022594-fx044gcd	410	6	enzyme	enzyme	NN
cord-022594-fx044gcd	410	7	activity	activity	NN
cord-022594-fx044gcd	410	8	levels	level	NNS
cord-022594-fx044gcd	410	9	will	will	MD
cord-022594-fx044gcd	410	10	confirm	confirm	VB
cord-022594-fx044gcd	410	11	the	the	DT
cord-022594-fx044gcd	410	12	diagnosis	diagnosis	NN
cord-022594-fx044gcd	410	13	of	of	IN
cord-022594-fx044gcd	410	14	Krabbe	Krabbe	NNP
cord-022594-fx044gcd	410	15	's	's	POS
cord-022594-fx044gcd	410	16	disease	disease	NN
cord-022594-fx044gcd	410	17	and	and	CC
cord-022594-fx044gcd	410	18	MLD	MLD	NNP
cord-022594-fx044gcd	410	19	,	,	,
cord-022594-fx044gcd	410	20	and	and	CC
cord-022594-fx044gcd	410	21	elevated	elevated	JJ
cord-022594-fx044gcd	410	22	levels	level	NNS
cord-022594-fx044gcd	410	23	of	of	IN
cord-022594-fx044gcd	410	24	very	very	RB
cord-022594-fx044gcd	410	25	long	long	JJ
cord-022594-fx044gcd	410	26	chain	chain	NN
cord-022594-fx044gcd	410	27	fatty	fatty	JJ
cord-022594-fx044gcd	410	28	acids	acid	NNS
cord-022594-fx044gcd	410	29	occur	occur	VBP
cord-022594-fx044gcd	410	30	in	in	IN
cord-022594-fx044gcd	410	31	ALD	ALD	NNP
cord-022594-fx044gcd	410	32	/	/	SYM
cord-022594-fx044gcd	410	33	AMN	AMN	NNP
cord-022594-fx044gcd	410	34	.	.	.
cord-022594-fx044gcd	411	1	Mitochondrial	mitochondrial	JJ
cord-022594-fx044gcd	411	2	disorders	disorder	NNS
cord-022594-fx044gcd	411	3	should	should	MD
cord-022594-fx044gcd	411	4	also	also	RB
cord-022594-fx044gcd	411	5	be	be	VB
cord-022594-fx044gcd	411	6	given	give	VBN
cord-022594-fx044gcd	411	7	consideration	consideration	NN
cord-022594-fx044gcd	411	8	because	because	IN
cord-022594-fx044gcd	411	9	symptoms	symptom	NNS
cord-022594-fx044gcd	411	10	and	and	CC
cord-022594-fx044gcd	411	11	MRI	MRI	NNP
cord-022594-fx044gcd	411	12	appearance	appearance	NN
cord-022594-fx044gcd	411	13	may	may	MD
cord-022594-fx044gcd	411	14	be	be	VB
cord-022594-fx044gcd	411	15	similar	similar	JJ
cord-022594-fx044gcd	411	16	to	to	IN
cord-022594-fx044gcd	411	17	MS	MS	NNP
cord-022594-fx044gcd	411	18	.	.	.
cord-022594-fx044gcd	412	1	A	a	DT
cord-022594-fx044gcd	412	2	relapsing	relapse	VBG
cord-022594-fx044gcd	412	3	remitting	remit	VBG
cord-022594-fx044gcd	412	4	disorder	disorder	NN
cord-022594-fx044gcd	412	5	identical	identical	JJ
cord-022594-fx044gcd	412	6	to	to	IN
cord-022594-fx044gcd	412	7	MS	MS	NNP
cord-022594-fx044gcd	412	8	is	be	VBZ
cord-022594-fx044gcd	412	9	sometimes	sometimes	RB
cord-022594-fx044gcd	412	10	seen	see	VBN
cord-022594-fx044gcd	412	11	in	in	IN
cord-022594-fx044gcd	412	12	patients	patient	NNS
cord-022594-fx044gcd	412	13	with	with	IN
cord-022594-fx044gcd	412	14	the	the	DT
cord-022594-fx044gcd	412	15	mutations	mutation	NNS
cord-022594-fx044gcd	412	16	responsible	responsible	JJ
cord-022594-fx044gcd	412	17	for	for	IN
cord-022594-fx044gcd	412	18	Leber	Leber	NNP
cord-022594-fx044gcd	412	19	's	's	POS
cord-022594-fx044gcd	412	20	hereditary	hereditary	JJ
cord-022594-fx044gcd	412	21	optic	optic	JJ
cord-022594-fx044gcd	412	22	neuritis	neuritis	NN
cord-022594-fx044gcd	412	23	(	(	-LRB-
cord-022594-fx044gcd	412	24	LHON	LHON	NNP
cord-022594-fx044gcd	412	25	)	)	-RRB-
cord-022594-fx044gcd	412	26	.	.	.
cord-022594-fx044gcd	413	1	41	41	CD
cord-022594-fx044gcd	414	1	This	this	DT
cord-022594-fx044gcd	414	2	usually	usually	RB
cord-022594-fx044gcd	414	3	occurs	occur	VBZ
cord-022594-fx044gcd	414	4	in	in	IN
cord-022594-fx044gcd	414	5	female	female	JJ
cord-022594-fx044gcd	414	6	patients	patient	NNS
cord-022594-fx044gcd	414	7	,	,	,
cord-022594-fx044gcd	414	8	and	and	CC
cord-022594-fx044gcd	414	9	there	there	EX
cord-022594-fx044gcd	414	10	may	may	MD
cord-022594-fx044gcd	414	11	not	not	RB
cord-022594-fx044gcd	414	12	be	be	VB
cord-022594-fx044gcd	414	13	a	a	DT
cord-022594-fx044gcd	414	14	family	family	NN
cord-022594-fx044gcd	414	15	history	history	NN
cord-022594-fx044gcd	414	16	of	of	IN
cord-022594-fx044gcd	414	17	visual	visual	JJ
cord-022594-fx044gcd	414	18	loss	loss	NN
cord-022594-fx044gcd	414	19	.	.	.
cord-022594-fx044gcd	415	1	A	a	DT
cord-022594-fx044gcd	415	2	number	number	NN
cord-022594-fx044gcd	415	3	of	of	IN
cord-022594-fx044gcd	415	4	rare	rare	JJ
cord-022594-fx044gcd	415	5	biochemically	biochemically	RB
cord-022594-fx044gcd	415	6	defined	define	VBN
cord-022594-fx044gcd	415	7	illnesses	illness	NNS
cord-022594-fx044gcd	415	8	and	and	CC
cord-022594-fx044gcd	415	9	other	other	JJ
cord-022594-fx044gcd	415	10	genetic	genetic	JJ
cord-022594-fx044gcd	415	11	disorders	disorder	NNS
cord-022594-fx044gcd	415	12	may	may	MD
cord-022594-fx044gcd	415	13	occasionally	occasionally	RB
cord-022594-fx044gcd	415	14	merit	merit	VB
cord-022594-fx044gcd	415	15	consideration	consideration	NN
cord-022594-fx044gcd	415	16	(	(	-LRB-
cord-022594-fx044gcd	415	17	including	include	VBG
cord-022594-fx044gcd	415	18	cobalamin	cobalamin	NN
cord-022594-fx044gcd	415	19	and	and	CC
cord-022594-fx044gcd	415	20	folate	folate	NN
cord-022594-fx044gcd	415	21	dysmetabolism	dysmetabolism	NN
cord-022594-fx044gcd	415	22	,	,	,
cord-022594-fx044gcd	415	23	adult	adult	NN
cord-022594-fx044gcd	415	24	polyglucosan	polyglucosan	JJ
cord-022594-fx044gcd	415	25	body	body	NN
cord-022594-fx044gcd	415	26	disease	disease	NN
cord-022594-fx044gcd	415	27	,	,	,
cord-022594-fx044gcd	415	28	hereditary	hereditary	JJ
cord-022594-fx044gcd	415	29	spastic	spastic	JJ
cord-022594-fx044gcd	415	30	paraparesis	paraparesis	NN
cord-022594-fx044gcd	415	31	,	,	,
cord-022594-fx044gcd	415	32	spinocerebellar	spinocerebellar	NNP
cord-022594-fx044gcd	415	33	degeneration	degeneration	NN
cord-022594-fx044gcd	415	34	,	,	,
cord-022594-fx044gcd	415	35	and	and	CC
cord-022594-fx044gcd	415	36	hereditary	hereditary	JJ
cord-022594-fx044gcd	415	37	cerebroretinal	cerebroretinal	JJ
cord-022594-fx044gcd	415	38	vasculopathy	vasculopathy	NNP
cord-022594-fx044gcd	415	39	)	)	-RRB-
cord-022594-fx044gcd	415	40	.	.	.
cord-022594-fx044gcd	416	1	42	42	CD
cord-022594-fx044gcd	416	2	Several	several	JJ
cord-022594-fx044gcd	416	3	additional	additional	JJ
cord-022594-fx044gcd	416	4	disorders	disorder	NNS
cord-022594-fx044gcd	416	5	must	must	MD
cord-022594-fx044gcd	416	6	be	be	VB
cord-022594-fx044gcd	416	7	excluded	exclude	VBN
cord-022594-fx044gcd	416	8	before	before	IN
cord-022594-fx044gcd	416	9	diagnosing	diagnose	VBG
cord-022594-fx044gcd	416	10	primary	primary	JJ
cord-022594-fx044gcd	416	11	progressive	progressive	JJ
cord-022594-fx044gcd	416	12	MS	MS	NNP
cord-022594-fx044gcd	416	13	(	(	-LRB-
cord-022594-fx044gcd	416	14	PPMS	PPMS	NNP
cord-022594-fx044gcd	416	15	)	)	-RRB-
cord-022594-fx044gcd	416	16	.	.	.
cord-022594-fx044gcd	417	1	Spinal	spinal	JJ
cord-022594-fx044gcd	417	2	cord	cord	NN
cord-022594-fx044gcd	417	3	compression	compression	NN
cord-022594-fx044gcd	417	4	from	from	IN
cord-022594-fx044gcd	417	5	spondylosis	spondylosis	NN
cord-022594-fx044gcd	417	6	or	or	CC
cord-022594-fx044gcd	417	7	tumor	tumor	NN
cord-022594-fx044gcd	417	8	may	may	MD
cord-022594-fx044gcd	417	9	produce	produce	VB
cord-022594-fx044gcd	417	10	chronic	chronic	JJ
cord-022594-fx044gcd	417	11	progressive	progressive	JJ
cord-022594-fx044gcd	417	12	myelopathy	myelopathy	NN
cord-022594-fx044gcd	417	13	.	.	.
cord-022594-fx044gcd	418	1	Chiari	Chiari	NNP
cord-022594-fx044gcd	418	2	malformations	malformation	NNS
cord-022594-fx044gcd	418	3	,	,	,
cord-022594-fx044gcd	418	4	syringomyelia	syringomyelia	NN
cord-022594-fx044gcd	418	5	,	,	,
cord-022594-fx044gcd	418	6	syringobulbia	syringobulbia	NNP
cord-022594-fx044gcd	418	7	,	,	,
cord-022594-fx044gcd	418	8	other	other	JJ
cord-022594-fx044gcd	418	9	foramen	foramen	NNP
cord-022594-fx044gcd	418	10	magnum	magnum	NNP
cord-022594-fx044gcd	418	11	lesions	lesion	NNS
cord-022594-fx044gcd	418	12	,	,	,
cord-022594-fx044gcd	418	13	spinal	spinal	JJ
cord-022594-fx044gcd	418	14	arteriovenous	arteriovenous	JJ
cord-022594-fx044gcd	418	15	malformations	malformation	NNS
cord-022594-fx044gcd	418	16	,	,	,
cord-022594-fx044gcd	418	17	and	and	CC
cord-022594-fx044gcd	418	18	dural	dural	NN
cord-022594-fx044gcd	418	19	fistulas	fistula	NNS
cord-022594-fx044gcd	418	20	may	may	MD
cord-022594-fx044gcd	418	21	also	also	RB
cord-022594-fx044gcd	418	22	need	need	VB
cord-022594-fx044gcd	418	23	consideration	consideration	NN
cord-022594-fx044gcd	418	24	.	.	.
cord-022594-fx044gcd	419	1	Careful	careful	JJ
cord-022594-fx044gcd	419	2	imaging	imaging	NN
cord-022594-fx044gcd	419	3	readily	readily	RB
cord-022594-fx044gcd	419	4	identifies	identify	VBZ
cord-022594-fx044gcd	419	5	these	these	DT
cord-022594-fx044gcd	419	6	structural	structural	JJ
cord-022594-fx044gcd	419	7	abnormalities	abnormality	NNS
cord-022594-fx044gcd	419	8	.	.	.
cord-022594-fx044gcd	420	1	Degenerative	degenerative	JJ
cord-022594-fx044gcd	420	2	diseases	disease	NNS
cord-022594-fx044gcd	420	3	such	such	JJ
cord-022594-fx044gcd	420	4	as	as	IN
cord-022594-fx044gcd	420	5	olivopontocerebellar	olivopontocerebellar	JJ
cord-022594-fx044gcd	420	6	atrophy	atrophy	NN
cord-022594-fx044gcd	420	7	may	may	MD
cord-022594-fx044gcd	420	8	mimic	mimic	VB
cord-022594-fx044gcd	420	9	PPMS	PPMS	NNP
cord-022594-fx044gcd	420	10	.	.	.
cord-022594-fx044gcd	421	1	MRI	MRI	NNP
cord-022594-fx044gcd	421	2	and	and	CC
cord-022594-fx044gcd	421	3	CSF	CSF	NNP
cord-022594-fx044gcd	421	4	examination	examination	NN
cord-022594-fx044gcd	421	5	will	will	MD
cord-022594-fx044gcd	421	6	help	help	VB
cord-022594-fx044gcd	421	7	distinguish	distinguish	VB
cord-022594-fx044gcd	421	8	between	between	IN
cord-022594-fx044gcd	421	9	the	the	DT
cord-022594-fx044gcd	421	10	two	two	CD
cord-022594-fx044gcd	421	11	.	.	.
cord-022594-fx044gcd	422	1	Conversion	conversion	NN
cord-022594-fx044gcd	422	2	reactions	reaction	NNS
cord-022594-fx044gcd	422	3	and	and	CC
cord-022594-fx044gcd	422	4	somatization	somatization	NN
cord-022594-fx044gcd	422	5	disorders	disorder	NNS
cord-022594-fx044gcd	422	6	are	be	VBP
cord-022594-fx044gcd	422	7	commonly	commonly	RB
cord-022594-fx044gcd	422	8	encountered	encounter	VBN
cord-022594-fx044gcd	422	9	in	in	IN
cord-022594-fx044gcd	422	10	a	a	DT
cord-022594-fx044gcd	422	11	busy	busy	JJ
cord-022594-fx044gcd	422	12	referral	referral	JJ
cord-022594-fx044gcd	422	13	practice	practice	NN
cord-022594-fx044gcd	422	14	and	and	CC
cord-022594-fx044gcd	422	15	must	must	MD
cord-022594-fx044gcd	422	16	be	be	VB
cord-022594-fx044gcd	422	17	accurately	accurately	RB
cord-022594-fx044gcd	422	18	diagnosed	diagnose	VBN
cord-022594-fx044gcd	422	19	to	to	TO
cord-022594-fx044gcd	422	20	afford	afford	VB
cord-022594-fx044gcd	422	21	optimal	optimal	JJ
cord-022594-fx044gcd	422	22	patient	patient	NN
cord-022594-fx044gcd	422	23	management	management	NN
cord-022594-fx044gcd	422	24	.	.	.
cord-022594-fx044gcd	423	1	EVALUATION	EVALUATION	NNP
cord-022594-fx044gcd	423	2	.	.	.
cord-022594-fx044gcd	424	1	The	the	DT
cord-022594-fx044gcd	424	2	diagnosis	diagnosis	NN
cord-022594-fx044gcd	424	3	of	of	IN
cord-022594-fx044gcd	424	4	MS	MS	NNP
cord-022594-fx044gcd	424	5	is	be	VBZ
cord-022594-fx044gcd	424	6	based	base	VBN
cord-022594-fx044gcd	424	7	on	on	IN
cord-022594-fx044gcd	424	8	the	the	DT
cord-022594-fx044gcd	424	9	demonstration	demonstration	NN
cord-022594-fx044gcd	424	10	of	of	IN
cord-022594-fx044gcd	424	11	white	white	JJ
cord-022594-fx044gcd	424	12	matter	matter	NN
cord-022594-fx044gcd	424	13	lesions	lesion	NNS
cord-022594-fx044gcd	424	14	disseminated	disseminate	VBN
cord-022594-fx044gcd	424	15	in	in	IN
cord-022594-fx044gcd	424	16	time	time	NN
cord-022594-fx044gcd	424	17	and	and	CC
cord-022594-fx044gcd	424	18	space	space	NN
cord-022594-fx044gcd	424	19	in	in	IN
cord-022594-fx044gcd	424	20	the	the	DT
cord-022594-fx044gcd	424	21	absence	absence	NN
cord-022594-fx044gcd	424	22	of	of	IN
cord-022594-fx044gcd	424	23	another	another	DT
cord-022594-fx044gcd	424	24	identifiable	identifiable	JJ
cord-022594-fx044gcd	424	25	explanation	explanation	NN
cord-022594-fx044gcd	424	26	.	.	.
cord-022594-fx044gcd	425	1	MS	MS	NNP
cord-022594-fx044gcd	425	2	remains	remain	VBZ
cord-022594-fx044gcd	425	3	a	a	DT
cord-022594-fx044gcd	425	4	clinical	clinical	JJ
cord-022594-fx044gcd	425	5	diagnosis	diagnosis	NN
cord-022594-fx044gcd	425	6	,	,	,
cord-022594-fx044gcd	425	7	although	although	IN
cord-022594-fx044gcd	425	8	MRI	MRI	NNP
cord-022594-fx044gcd	425	9	,	,	,
cord-022594-fx044gcd	425	10	evoked	evoke	VBD
cord-022594-fx044gcd	425	11	potentials	potential	NNS
cord-022594-fx044gcd	425	12	,	,	,
cord-022594-fx044gcd	425	13	and	and	CC
cord-022594-fx044gcd	425	14	CSF	csf	NN
cord-022594-fx044gcd	425	15	examination	examination	NN
cord-022594-fx044gcd	425	16	can	can	MD
cord-022594-fx044gcd	425	17	help	help	VB
cord-022594-fx044gcd	425	18	clarify	clarify	VB
cord-022594-fx044gcd	425	19	less	less	RBR
cord-022594-fx044gcd	425	20	certain	certain	JJ
cord-022594-fx044gcd	425	21	cases	case	NNS
cord-022594-fx044gcd	425	22	.	.	.
cord-022594-fx044gcd	426	1	For	for	IN
cord-022594-fx044gcd	426	2	research	research	NN
cord-022594-fx044gcd	426	3	purposes	purpose	NNS
cord-022594-fx044gcd	426	4	,	,	,
cord-022594-fx044gcd	426	5	various	various	JJ
cord-022594-fx044gcd	426	6	categories	category	NNS
cord-022594-fx044gcd	426	7	of	of	IN
cord-022594-fx044gcd	426	8	MS	MS	NNP
cord-022594-fx044gcd	426	9	have	have	VBP
cord-022594-fx044gcd	426	10	been	be	VBN
cord-022594-fx044gcd	426	11	defined	define	VBN
cord-022594-fx044gcd	426	12	based	base	VBN
cord-022594-fx044gcd	426	13	on	on	IN
cord-022594-fx044gcd	426	14	the	the	DT
cord-022594-fx044gcd	426	15	certainty	certainty	NN
cord-022594-fx044gcd	426	16	of	of	IN
cord-022594-fx044gcd	426	17	the	the	DT
cord-022594-fx044gcd	426	18	diagnosis	diagnosis	NN
cord-022594-fx044gcd	426	19	.	.	.
cord-022594-fx044gcd	427	1	43	43	CD
cord-022594-fx044gcd	428	1	At	at	RB
cord-022594-fx044gcd	428	2	least	least	RBS
cord-022594-fx044gcd	428	3	two	two	CD
cord-022594-fx044gcd	428	4	attacks	attack	NNS
cord-022594-fx044gcd	428	5	and	and	CC
cord-022594-fx044gcd	428	6	evidence	evidence	NN
cord-022594-fx044gcd	428	7	of	of	IN
cord-022594-fx044gcd	428	8	two	two	CD
cord-022594-fx044gcd	428	9	separate	separate	JJ
cord-022594-fx044gcd	428	10	CNS	CNS	NNP
cord-022594-fx044gcd	428	11	lesions	lesion	NNS
cord-022594-fx044gcd	428	12	(	(	-LRB-
cord-022594-fx044gcd	428	13	clinical	clinical	JJ
cord-022594-fx044gcd	428	14	or	or	CC
cord-022594-fx044gcd	428	15	paraclinical	paraclinical	JJ
cord-022594-fx044gcd	428	16	)	)	-RRB-
cord-022594-fx044gcd	428	17	are	be	VBP
cord-022594-fx044gcd	428	18	required	require	VBN
cord-022594-fx044gcd	428	19	for	for	IN
cord-022594-fx044gcd	428	20	the	the	DT
cord-022594-fx044gcd	428	21	designation	designation	NN
cord-022594-fx044gcd	428	22	of	of	IN
cord-022594-fx044gcd	428	23	clinically	clinically	RB
cord-022594-fx044gcd	428	24	definite	definite	JJ
cord-022594-fx044gcd	428	25	MS	MS	NNP
cord-022594-fx044gcd	428	26	(	(	-LRB-
cord-022594-fx044gcd	428	27	CDMS	CDMS	NNP
cord-022594-fx044gcd	428	28	)	)	-RRB-
cord-022594-fx044gcd	428	29	.	.	.
cord-022594-fx044gcd	429	1	Two	two	CD
cord-022594-fx044gcd	429	2	attacks	attack	NNS
cord-022594-fx044gcd	429	3	and	and	CC
cord-022594-fx044gcd	429	4	evidence	evidence	NN
cord-022594-fx044gcd	429	5	of	of	IN
cord-022594-fx044gcd	429	6	one	one	CD
cord-022594-fx044gcd	429	7	CNS	CNS	NNP
cord-022594-fx044gcd	429	8	lesion	lesion	NN
cord-022594-fx044gcd	429	9	or	or	CC
cord-022594-fx044gcd	429	10	one	one	CD
cord-022594-fx044gcd	429	11	attack	attack	NN
cord-022594-fx044gcd	429	12	and	and	CC
cord-022594-fx044gcd	429	13	evidence	evidence	NN
cord-022594-fx044gcd	429	14	of	of	IN
cord-022594-fx044gcd	429	15	two	two	CD
cord-022594-fx044gcd	429	16	CNS	CNS	NNP
cord-022594-fx044gcd	429	17	lesions	lesion	NNS
cord-022594-fx044gcd	429	18	(	(	-LRB-
cord-022594-fx044gcd	429	19	clinical	clinical	JJ
cord-022594-fx044gcd	429	20	or	or	CC
cord-022594-fx044gcd	429	21	paraclinical	paraclinical	JJ
cord-022594-fx044gcd	429	22	)	)	-RRB-
cord-022594-fx044gcd	429	23	is	be	VBZ
cord-022594-fx044gcd	429	24	considered	consider	VBN
cord-022594-fx044gcd	429	25	clinically	clinically	RB
cord-022594-fx044gcd	429	26	probable	probable	JJ
cord-022594-fx044gcd	429	27	MS	m	NNS
cord-022594-fx044gcd	429	28	.	.	.
cord-022594-fx044gcd	430	1	Cases	case	NNS
cord-022594-fx044gcd	430	2	that	that	WDT
cord-022594-fx044gcd	430	3	fulfill	fulfill	VBP
cord-022594-fx044gcd	430	4	the	the	DT
cord-022594-fx044gcd	430	5	criteria	criterion	NNS
cord-022594-fx044gcd	430	6	for	for	IN
cord-022594-fx044gcd	430	7	clinically	clinically	RB
cord-022594-fx044gcd	430	8	probable	probable	JJ
cord-022594-fx044gcd	430	9	MS	m	NNS
cord-022594-fx044gcd	430	10	and	and	CC
cord-022594-fx044gcd	430	11	have	have	VBP
cord-022594-fx044gcd	430	12	supportive	supportive	JJ
cord-022594-fx044gcd	430	13	CSF	CSF	NNP
cord-022594-fx044gcd	430	14	findings	finding	NNS
cord-022594-fx044gcd	430	15	are	be	VBP
cord-022594-fx044gcd	430	16	labeled	label	VBN
cord-022594-fx044gcd	430	17	as	as	IN
cord-022594-fx044gcd	430	18	laboratory	laboratory	NN
cord-022594-fx044gcd	430	19	-	-	HYPH
cord-022594-fx044gcd	430	20	supported	support	VBN
cord-022594-fx044gcd	430	21	definite	definite	JJ
cord-022594-fx044gcd	430	22	MS	MS	NNP
cord-022594-fx044gcd	430	23	.	.	.
cord-022594-fx044gcd	431	1	Patients	patient	NNS
cord-022594-fx044gcd	431	2	with	with	IN
cord-022594-fx044gcd	431	3	a	a	DT
cord-022594-fx044gcd	431	4	clear	clear	JJ
cord-022594-fx044gcd	431	5	history	history	NN
cord-022594-fx044gcd	431	6	of	of	IN
cord-022594-fx044gcd	431	7	at	at	RB
cord-022594-fx044gcd	431	8	least	least	RBS
cord-022594-fx044gcd	431	9	two	two	CD
cord-022594-fx044gcd	431	10	attacks	attack	NNS
cord-022594-fx044gcd	431	11	and	and	CC
cord-022594-fx044gcd	431	12	supportive	supportive	JJ
cord-022594-fx044gcd	431	13	CSF	csf	NN
cord-022594-fx044gcd	431	14	but	but	CC
cord-022594-fx044gcd	431	15	a	a	DT
cord-022594-fx044gcd	431	16	normal	normal	JJ
cord-022594-fx044gcd	431	17	neurological	neurological	JJ
cord-022594-fx044gcd	431	18	examination	examination	NN
cord-022594-fx044gcd	431	19	and	and	CC
cord-022594-fx044gcd	431	20	no	no	DT
cord-022594-fx044gcd	431	21	paraclinical	paraclinical	JJ
cord-022594-fx044gcd	431	22	evidence	evidence	NN
cord-022594-fx044gcd	431	23	of	of	IN
cord-022594-fx044gcd	431	24	CNS	CNS	NNP
cord-022594-fx044gcd	431	25	lesions	lesion	NNS
cord-022594-fx044gcd	431	26	are	be	VBP
cord-022594-fx044gcd	431	27	categorized	categorize	VBN
cord-022594-fx044gcd	431	28	as	as	IN
cord-022594-fx044gcd	431	29	having	have	VBG
cord-022594-fx044gcd	431	30	laboratory	laboratory	NN
cord-022594-fx044gcd	431	31	-	-	HYPH
cord-022594-fx044gcd	431	32	supported	support	VBN
cord-022594-fx044gcd	431	33	probable	probable	JJ
cord-022594-fx044gcd	431	34	MS	MS	NNP
cord-022594-fx044gcd	431	35	.	.	.
cord-022594-fx044gcd	432	1	Suspected	suspect	VBN
cord-022594-fx044gcd	432	2	cases	case	NNS
cord-022594-fx044gcd	432	3	that	that	WDT
cord-022594-fx044gcd	432	4	do	do	VBP
cord-022594-fx044gcd	432	5	not	not	RB
cord-022594-fx044gcd	432	6	fit	fit	VB
cord-022594-fx044gcd	432	7	any	any	DT
cord-022594-fx044gcd	432	8	of	of	IN
cord-022594-fx044gcd	432	9	these	these	DT
cord-022594-fx044gcd	432	10	criteria	criterion	NNS
cord-022594-fx044gcd	432	11	may	may	MD
cord-022594-fx044gcd	432	12	be	be	VB
cord-022594-fx044gcd	432	13	regarded	regard	VBN
cord-022594-fx044gcd	432	14	as	as	IN
cord-022594-fx044gcd	432	15	possible	possible	JJ
cord-022594-fx044gcd	432	16	MS	MS	NNP
cord-022594-fx044gcd	432	17	.	.	.
cord-022594-fx044gcd	433	1	Paraclinical	paraclinical	JJ
cord-022594-fx044gcd	433	2	evidence	evidence	NN
cord-022594-fx044gcd	433	3	generally	generally	RB
cord-022594-fx044gcd	433	4	refers	refer	VBZ
cord-022594-fx044gcd	433	5	to	to	IN
cord-022594-fx044gcd	433	6	abnormalities	abnormality	NNS
cord-022594-fx044gcd	433	7	on	on	IN
cord-022594-fx044gcd	433	8	evoked	evoke	VBN
cord-022594-fx044gcd	433	9	potential	potential	JJ
cord-022594-fx044gcd	433	10	studies	study	NNS
cord-022594-fx044gcd	433	11	or	or	CC
cord-022594-fx044gcd	433	12	imaging	imaging	NN
cord-022594-fx044gcd	433	13	procedures	procedure	NNS
cord-022594-fx044gcd	433	14	.	.	.
cord-022594-fx044gcd	434	1	As	as	IN
cord-022594-fx044gcd	434	2	a	a	DT
cord-022594-fx044gcd	434	3	result	result	NN
cord-022594-fx044gcd	434	4	of	of	IN
cord-022594-fx044gcd	434	5	increasing	increase	VBG
cord-022594-fx044gcd	434	6	availability	availability	NN
cord-022594-fx044gcd	434	7	of	of	IN
cord-022594-fx044gcd	434	8	refined	refined	JJ
cord-022594-fx044gcd	434	9	paraclinical	paraclinical	JJ
cord-022594-fx044gcd	434	10	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	434	11	modalities	modality	NNS
cord-022594-fx044gcd	434	12	(	(	-LRB-
cord-022594-fx044gcd	434	13	especially	especially	RB
cord-022594-fx044gcd	434	14	MRI	MRI	NNP
cord-022594-fx044gcd	434	15	)	)	-RRB-
cord-022594-fx044gcd	434	16	and	and	CC
cord-022594-fx044gcd	434	17	an	an	DT
cord-022594-fx044gcd	434	18	overall	overall	JJ
cord-022594-fx044gcd	434	19	better	well	JJR
cord-022594-fx044gcd	434	20	understanding	understanding	NN
cord-022594-fx044gcd	434	21	of	of	IN
cord-022594-fx044gcd	434	22	the	the	DT
cord-022594-fx044gcd	434	23	disease	disease	NN
cord-022594-fx044gcd	434	24	process	process	NN
cord-022594-fx044gcd	434	25	,	,	,
cord-022594-fx044gcd	434	26	new	new	JJ
cord-022594-fx044gcd	434	27	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	434	28	criteria	criterion	NNS
cord-022594-fx044gcd	434	29	for	for	IN
cord-022594-fx044gcd	434	30	MS	MS	NNP
cord-022594-fx044gcd	434	31	were	be	VBD
cord-022594-fx044gcd	434	32	proposed	propose	VBN
cord-022594-fx044gcd	434	33	by	by	IN
cord-022594-fx044gcd	434	34	an	an	DT
cord-022594-fx044gcd	434	35	international	international	JJ
cord-022594-fx044gcd	434	36	expert	expert	JJ
cord-022594-fx044gcd	434	37	panel	panel	NN
cord-022594-fx044gcd	434	38	in	in	IN
cord-022594-fx044gcd	434	39	2001	2001	CD
cord-022594-fx044gcd	434	40	.	.	.
cord-022594-fx044gcd	435	1	44	44	CD
cord-022594-fx044gcd	435	2	Three	three	CD
cord-022594-fx044gcd	435	3	out	out	IN
cord-022594-fx044gcd	435	4	of	of	IN
cord-022594-fx044gcd	435	5	four	four	CD
cord-022594-fx044gcd	435	6	of	of	IN
cord-022594-fx044gcd	435	7	the	the	DT
cord-022594-fx044gcd	435	8	following	follow	VBG
cord-022594-fx044gcd	435	9	findings	finding	NNS
cord-022594-fx044gcd	435	10	should	should	MD
cord-022594-fx044gcd	435	11	be	be	VB
cord-022594-fx044gcd	435	12	present	present	JJ
cord-022594-fx044gcd	435	13	on	on	IN
cord-022594-fx044gcd	435	14	MRI	MRI	NNP
cord-022594-fx044gcd	435	15	:	:	:
cord-022594-fx044gcd	436	1	(	(	-LRB-
cord-022594-fx044gcd	436	2	1	1	LS
cord-022594-fx044gcd	436	3	)	)	-RRB-
cord-022594-fx044gcd	436	4	one	one	CD
cord-022594-fx044gcd	436	5	gadolinium	gadolinium	NN
cord-022594-fx044gcd	436	6	enhancing	enhance	VBG
cord-022594-fx044gcd	436	7	lesion	lesion	NN
cord-022594-fx044gcd	436	8	,	,	,
cord-022594-fx044gcd	436	9	or	or	CC
cord-022594-fx044gcd	436	10	nine	nine	CD
cord-022594-fx044gcd	436	11	T2	T2	NNP
cord-022594-fx044gcd	436	12	hyperintense	hyperintense	NN
cord-022594-fx044gcd	436	13	lesions	lesion	NNS
cord-022594-fx044gcd	436	14	;	;	,
cord-022594-fx044gcd	436	15	(	(	-LRB-
cord-022594-fx044gcd	436	16	2	2	LS
cord-022594-fx044gcd	436	17	)	)	-RRB-
cord-022594-fx044gcd	436	18	at	at	IN
cord-022594-fx044gcd	436	19	least	least	RBS
cord-022594-fx044gcd	436	20	one	one	CD
cord-022594-fx044gcd	436	21	infratentorial	infratentorial	JJ
cord-022594-fx044gcd	436	22	lesion	lesion	NN
cord-022594-fx044gcd	436	23	;	;	,
cord-022594-fx044gcd	436	24	(	(	-LRB-
cord-022594-fx044gcd	436	25	3	3	LS
cord-022594-fx044gcd	436	26	)	)	-RRB-
cord-022594-fx044gcd	436	27	at	at	IN
cord-022594-fx044gcd	436	28	least	least	JJS
cord-022594-fx044gcd	436	29	one	one	CD
cord-022594-fx044gcd	436	30	juxtacortical	juxtacortical	JJ
cord-022594-fx044gcd	436	31	lesion	lesion	NN
cord-022594-fx044gcd	436	32	;	;	,
cord-022594-fx044gcd	436	33	and	and	CC
cord-022594-fx044gcd	436	34	(	(	-LRB-
cord-022594-fx044gcd	436	35	4	4	LS
cord-022594-fx044gcd	436	36	)	)	-RRB-
cord-022594-fx044gcd	436	37	at	at	RB
cord-022594-fx044gcd	436	38	least	least	RBS
cord-022594-fx044gcd	436	39	three	three	CD
cord-022594-fx044gcd	436	40	periventricular	periventricular	NNP
cord-022594-fx044gcd	436	41	lesions	lesion	NNS
cord-022594-fx044gcd	436	42	.	.	.
cord-022594-fx044gcd	437	1	According	accord	VBG
cord-022594-fx044gcd	437	2	to	to	IN
cord-022594-fx044gcd	437	3	the	the	DT
cord-022594-fx044gcd	437	4	clinical	clinical	JJ
cord-022594-fx044gcd	437	5	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	437	6	criteria	criterion	NNS
cord-022594-fx044gcd	437	7	,	,	,
cord-022594-fx044gcd	437	8	if	if	IN
cord-022594-fx044gcd	437	9	a	a	DT
cord-022594-fx044gcd	437	10	patient	patient	NN
cord-022594-fx044gcd	437	11	had	have	VBD
cord-022594-fx044gcd	437	12	two	two	CD
cord-022594-fx044gcd	437	13	or	or	CC
cord-022594-fx044gcd	437	14	more	more	JJR
cord-022594-fx044gcd	437	15	attacks	attack	NNS
cord-022594-fx044gcd	437	16	with	with	IN
cord-022594-fx044gcd	437	17	objective	objective	JJ
cord-022594-fx044gcd	437	18	evidence	evidence	NN
cord-022594-fx044gcd	437	19	on	on	IN
cord-022594-fx044gcd	437	20	examination	examination	NN
cord-022594-fx044gcd	437	21	of	of	IN
cord-022594-fx044gcd	437	22	two	two	CD
cord-022594-fx044gcd	437	23	or	or	CC
cord-022594-fx044gcd	437	24	more	more	RBR
cord-022594-fx044gcd	437	25	anatomical	anatomical	JJ
cord-022594-fx044gcd	437	26	areas	area	NNS
cord-022594-fx044gcd	437	27	involved	involve	VBN
cord-022594-fx044gcd	437	28	,	,	,
cord-022594-fx044gcd	437	29	no	no	DT
cord-022594-fx044gcd	437	30	additional	additional	JJ
cord-022594-fx044gcd	437	31	data	data	NN
cord-022594-fx044gcd	437	32	is	be	VBZ
cord-022594-fx044gcd	437	33	required	require	VBN
cord-022594-fx044gcd	437	34	to	to	TO
cord-022594-fx044gcd	437	35	make	make	VB
cord-022594-fx044gcd	437	36	the	the	DT
cord-022594-fx044gcd	437	37	definite	definite	JJ
cord-022594-fx044gcd	437	38	diagnosis	diagnosis	NN
cord-022594-fx044gcd	437	39	.	.	.
cord-022594-fx044gcd	438	1	However	however	RB
cord-022594-fx044gcd	438	2	,	,	,
cord-022594-fx044gcd	438	3	if	if	IN
cord-022594-fx044gcd	438	4	such	such	JJ
cord-022594-fx044gcd	438	5	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	438	6	studies	study	NNS
cord-022594-fx044gcd	438	7	were	be	VBD
cord-022594-fx044gcd	438	8	done	do	VBN
cord-022594-fx044gcd	438	9	and	and	CC
cord-022594-fx044gcd	438	10	are	be	VBP
cord-022594-fx044gcd	438	11	not	not	RB
cord-022594-fx044gcd	438	12	supportive	supportive	JJ
cord-022594-fx044gcd	438	13	of	of	IN
cord-022594-fx044gcd	438	14	a	a	DT
cord-022594-fx044gcd	438	15	diagnosis	diagnosis	NN
cord-022594-fx044gcd	438	16	of	of	IN
cord-022594-fx044gcd	438	17	MS	MS	NNP
cord-022594-fx044gcd	438	18	,	,	,
cord-022594-fx044gcd	438	19	then	then	RB
cord-022594-fx044gcd	438	20	the	the	DT
cord-022594-fx044gcd	438	21	diagnosis	diagnosis	NN
cord-022594-fx044gcd	438	22	should	should	MD
cord-022594-fx044gcd	438	23	be	be	VB
cord-022594-fx044gcd	438	24	reconsidered	reconsider	VBN
cord-022594-fx044gcd	438	25	.	.	.
cord-022594-fx044gcd	439	1	If	if	IN
cord-022594-fx044gcd	439	2	a	a	DT
cord-022594-fx044gcd	439	3	patient	patient	NN
cord-022594-fx044gcd	439	4	presents	present	VBZ
cord-022594-fx044gcd	439	5	with	with	IN
cord-022594-fx044gcd	439	6	a	a	DT
cord-022594-fx044gcd	439	7	history	history	NN
cord-022594-fx044gcd	439	8	of	of	IN
cord-022594-fx044gcd	439	9	two	two	CD
cord-022594-fx044gcd	439	10	or	or	CC
cord-022594-fx044gcd	439	11	more	more	JJR
cord-022594-fx044gcd	439	12	attacks	attack	NNS
cord-022594-fx044gcd	439	13	,	,	,
cord-022594-fx044gcd	439	14	but	but	CC
cord-022594-fx044gcd	439	15	objective	objective	JJ
cord-022594-fx044gcd	439	16	clinical	clinical	JJ
cord-022594-fx044gcd	439	17	evidence	evidence	NN
cord-022594-fx044gcd	439	18	only	only	RB
cord-022594-fx044gcd	439	19	suggests	suggest	VBZ
cord-022594-fx044gcd	439	20	one	one	CD
cord-022594-fx044gcd	439	21	lesion	lesion	NN
cord-022594-fx044gcd	439	22	,	,	,
cord-022594-fx044gcd	439	23	the	the	DT
cord-022594-fx044gcd	439	24	following	follow	VBG
cord-022594-fx044gcd	439	25	additional	additional	JJ
cord-022594-fx044gcd	439	26	data	datum	NNS
cord-022594-fx044gcd	439	27	is	be	VBZ
cord-022594-fx044gcd	439	28	needed	need	VBN
cord-022594-fx044gcd	439	29	to	to	TO
cord-022594-fx044gcd	439	30	confirm	confirm	VB
cord-022594-fx044gcd	439	31	the	the	DT
cord-022594-fx044gcd	439	32	diagnosis	diagnosis	NN
cord-022594-fx044gcd	439	33	:	:	:
cord-022594-fx044gcd	439	34	the	the	DT
cord-022594-fx044gcd	439	35	disease	disease	NN
cord-022594-fx044gcd	439	36	process	process	NN
cord-022594-fx044gcd	439	37	has	have	VBZ
cord-022594-fx044gcd	439	38	to	to	TO
cord-022594-fx044gcd	439	39	be	be	VB
cord-022594-fx044gcd	439	40	disseminated	disseminate	VBN
cord-022594-fx044gcd	439	41	in	in	IN
cord-022594-fx044gcd	439	42	space	space	NN
cord-022594-fx044gcd	439	43	as	as	IN
cord-022594-fx044gcd	439	44	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	439	45	by	by	IN
cord-022594-fx044gcd	439	46	MRI	MRI	NNP
cord-022594-fx044gcd	439	47	;	;	:
cord-022594-fx044gcd	439	48	alternatively	alternatively	RB
cord-022594-fx044gcd	439	49	,	,	,
cord-022594-fx044gcd	439	50	two	two	CD
cord-022594-fx044gcd	439	51	or	or	CC
cord-022594-fx044gcd	439	52	more	more	JJR
cord-022594-fx044gcd	439	53	MRI	MRI	NNP
cord-022594-fx044gcd	439	54	-	-	HYPH
cord-022594-fx044gcd	439	55	detected	detect	VBN
cord-022594-fx044gcd	439	56	lesions	lesion	NNS
cord-022594-fx044gcd	439	57	consistent	consistent	JJ
cord-022594-fx044gcd	439	58	with	with	IN
cord-022594-fx044gcd	439	59	MS	MS	NNP
cord-022594-fx044gcd	439	60	plus	plus	CC
cord-022594-fx044gcd	439	61	positive	positive	JJ
cord-022594-fx044gcd	439	62	CSF	CSF	NNP
cord-022594-fx044gcd	439	63	would	would	MD
cord-022594-fx044gcd	439	64	suffice	suffice	VB
cord-022594-fx044gcd	439	65	to	to	TO
cord-022594-fx044gcd	439	66	meet	meet	VB
cord-022594-fx044gcd	439	67	the	the	DT
cord-022594-fx044gcd	439	68	newly	newly	RB
cord-022594-fx044gcd	439	69	defined	define	VBN
cord-022594-fx044gcd	439	70	criteria	criterion	NNS
cord-022594-fx044gcd	439	71	.	.	.
cord-022594-fx044gcd	440	1	The	the	DT
cord-022594-fx044gcd	440	2	clinician	clinician	NN
cord-022594-fx044gcd	440	3	also	also	RB
cord-022594-fx044gcd	440	4	may	may	MD
cord-022594-fx044gcd	440	5	elect	elect	VB
cord-022594-fx044gcd	440	6	to	to	TO
cord-022594-fx044gcd	440	7	await	await	VB
cord-022594-fx044gcd	440	8	a	a	DT
cord-022594-fx044gcd	440	9	further	further	JJ
cord-022594-fx044gcd	440	10	attack	attack	NN
cord-022594-fx044gcd	440	11	implicating	implicate	VBG
cord-022594-fx044gcd	440	12	a	a	DT
cord-022594-fx044gcd	440	13	different	different	JJ
cord-022594-fx044gcd	440	14	anatomical	anatomical	JJ
cord-022594-fx044gcd	440	15	site	site	NN
cord-022594-fx044gcd	440	16	.	.	.
cord-022594-fx044gcd	441	1	In	in	IN
cord-022594-fx044gcd	441	2	case	case	NN
cord-022594-fx044gcd	441	3	a	a	DT
cord-022594-fx044gcd	441	4	patient	patient	NN
cord-022594-fx044gcd	441	5	had	have	VBD
cord-022594-fx044gcd	441	6	one	one	CD
cord-022594-fx044gcd	441	7	attack	attack	NN
cord-022594-fx044gcd	441	8	,	,	,
cord-022594-fx044gcd	441	9	with	with	IN
cord-022594-fx044gcd	441	10	objective	objective	JJ
cord-022594-fx044gcd	441	11	clinical	clinical	JJ
cord-022594-fx044gcd	441	12	evidence	evidence	NN
cord-022594-fx044gcd	441	13	of	of	IN
cord-022594-fx044gcd	441	14	two	two	CD
cord-022594-fx044gcd	441	15	or	or	CC
cord-022594-fx044gcd	441	16	more	more	JJR
cord-022594-fx044gcd	441	17	lesions	lesion	NNS
cord-022594-fx044gcd	441	18	,	,	,
cord-022594-fx044gcd	441	19	dissemination	dissemination	NN
cord-022594-fx044gcd	441	20	in	in	IN
cord-022594-fx044gcd	441	21	time	time	NN
cord-022594-fx044gcd	441	22	as	as	IN
cord-022594-fx044gcd	441	23	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	441	24	by	by	IN
cord-022594-fx044gcd	441	25	serial	serial	JJ
cord-022594-fx044gcd	441	26	MRIs	mri	NNS
cord-022594-fx044gcd	441	27	separated	separate	VBN
cord-022594-fx044gcd	441	28	by	by	IN
cord-022594-fx044gcd	441	29	at	at	RB
cord-022594-fx044gcd	441	30	least	least	RBS
cord-022594-fx044gcd	441	31	3	3	CD
cord-022594-fx044gcd	441	32	months	month	NNS
cord-022594-fx044gcd	441	33	or	or	CC
cord-022594-fx044gcd	441	34	a	a	DT
cord-022594-fx044gcd	441	35	second	second	JJ
cord-022594-fx044gcd	441	36	clinical	clinical	JJ
cord-022594-fx044gcd	441	37	attack	attack	NN
cord-022594-fx044gcd	441	38	would	would	MD
cord-022594-fx044gcd	441	39	clarify	clarify	VB
cord-022594-fx044gcd	441	40	the	the	DT
cord-022594-fx044gcd	441	41	diagnosis	diagnosis	NN
cord-022594-fx044gcd	441	42	.	.	.
cord-022594-fx044gcd	442	1	If	if	IN
cord-022594-fx044gcd	442	2	a	a	DT
cord-022594-fx044gcd	442	3	patient	patient	NN
cord-022594-fx044gcd	442	4	has	have	VBZ
cord-022594-fx044gcd	442	5	a	a	DT
cord-022594-fx044gcd	442	6	clinically	clinically	RB
cord-022594-fx044gcd	442	7	isolated	isolate	VBN
cord-022594-fx044gcd	442	8	syndrome	syndrome	NN
cord-022594-fx044gcd	442	9	,	,	,
cord-022594-fx044gcd	442	10	or	or	CC
cord-022594-fx044gcd	442	11	"	"	``
cord-022594-fx044gcd	442	12	monosymptomatic	monosymptomatic	JJ
cord-022594-fx044gcd	442	13	"	"	''
cord-022594-fx044gcd	442	14	presentation	presentation	NN
cord-022594-fx044gcd	442	15	,	,	,
cord-022594-fx044gcd	442	16	the	the	DT
cord-022594-fx044gcd	442	17	following	follow	VBG
cord-022594-fx044gcd	442	18	criteria	criterion	NNS
cord-022594-fx044gcd	442	19	should	should	MD
cord-022594-fx044gcd	442	20	be	be	VB
cord-022594-fx044gcd	442	21	met	meet	VBN
cord-022594-fx044gcd	442	22	:	:	:
cord-022594-fx044gcd	442	23	dissemination	dissemination	NN
cord-022594-fx044gcd	442	24	in	in	IN
cord-022594-fx044gcd	442	25	space	space	NN
cord-022594-fx044gcd	442	26	as	as	IN
cord-022594-fx044gcd	442	27	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	442	28	by	by	IN
cord-022594-fx044gcd	442	29	MRI	MRI	NNP
cord-022594-fx044gcd	442	30	(	(	-LRB-
cord-022594-fx044gcd	442	31	again	again	RB
cord-022594-fx044gcd	442	32	separated	separate	VBN
cord-022594-fx044gcd	442	33	by	by	IN
cord-022594-fx044gcd	442	34	at	at	RB
cord-022594-fx044gcd	442	35	least	least	JJS
cord-022594-fx044gcd	442	36	3	3	CD
cord-022594-fx044gcd	442	37	months	month	NNS
cord-022594-fx044gcd	442	38	)	)	-RRB-
cord-022594-fx044gcd	442	39	,	,	,
cord-022594-fx044gcd	442	40	or	or	CC
cord-022594-fx044gcd	442	41	two	two	CD
cord-022594-fx044gcd	442	42	or	or	CC
cord-022594-fx044gcd	442	43	more	more	JJR
cord-022594-fx044gcd	442	44	MRIdetected	mridetected	JJ
cord-022594-fx044gcd	442	45	lesions	lesion	NNS
cord-022594-fx044gcd	442	46	consistent	consistent	JJ
cord-022594-fx044gcd	442	47	with	with	IN
cord-022594-fx044gcd	442	48	MS	MS	NNP
cord-022594-fx044gcd	442	49	plus	plus	CC
cord-022594-fx044gcd	442	50	positive	positive	JJ
cord-022594-fx044gcd	442	51	CSF	csf	NN
cord-022594-fx044gcd	442	52	and	and	CC
cord-022594-fx044gcd	442	53	dissemination	dissemination	NN
cord-022594-fx044gcd	442	54	in	in	IN
cord-022594-fx044gcd	442	55	time	time	NN
cord-022594-fx044gcd	442	56	on	on	IN
cord-022594-fx044gcd	442	57	serial	serial	JJ
cord-022594-fx044gcd	442	58	MRI	MRI	NNP
cord-022594-fx044gcd	442	59	scans	scan	NNS
cord-022594-fx044gcd	442	60	,	,	,
cord-022594-fx044gcd	442	61	or	or	CC
cord-022594-fx044gcd	442	62	a	a	DT
cord-022594-fx044gcd	442	63	second	second	JJ
cord-022594-fx044gcd	442	64	clinical	clinical	JJ
cord-022594-fx044gcd	442	65	attack	attack	NN
cord-022594-fx044gcd	442	66	.	.	.
cord-022594-fx044gcd	443	1	In	in	IN
cord-022594-fx044gcd	443	2	case	case	NN
cord-022594-fx044gcd	443	3	the	the	DT
cord-022594-fx044gcd	443	4	patient	patient	NN
cord-022594-fx044gcd	443	5	presents	present	VBZ
cord-022594-fx044gcd	443	6	with	with	IN
cord-022594-fx044gcd	443	7	a	a	DT
cord-022594-fx044gcd	443	8	progressive	progressive	JJ
cord-022594-fx044gcd	443	9	course	course	NN
cord-022594-fx044gcd	443	10	,	,	,
cord-022594-fx044gcd	443	11	the	the	DT
cord-022594-fx044gcd	443	12	presence	presence	NN
cord-022594-fx044gcd	443	13	of	of	IN
cord-022594-fx044gcd	443	14	positive	positive	JJ
cord-022594-fx044gcd	443	15	CSF	CSF	NNP
cord-022594-fx044gcd	443	16	is	be	VBZ
cord-022594-fx044gcd	443	17	required	require	VBN
cord-022594-fx044gcd	443	18	,	,	,
cord-022594-fx044gcd	443	19	and	and	CC
cord-022594-fx044gcd	443	20	dissemination	dissemination	NN
cord-022594-fx044gcd	443	21	in	in	IN
cord-022594-fx044gcd	443	22	space	space	NN
cord-022594-fx044gcd	443	23	should	should	MD
cord-022594-fx044gcd	443	24	be	be	VB
cord-022594-fx044gcd	443	25	present	present	JJ
cord-022594-fx044gcd	443	26	,	,	,
cord-022594-fx044gcd	443	27	as	as	IN
cord-022594-fx044gcd	443	28	suggested	suggest	VBN
cord-022594-fx044gcd	443	29	by	by	IN
cord-022594-fx044gcd	443	30	nine	nine	CD
cord-022594-fx044gcd	443	31	or	or	CC
cord-022594-fx044gcd	443	32	more	more	JJR
cord-022594-fx044gcd	443	33	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	443	34	brain	brain	NN
cord-022594-fx044gcd	443	35	lesions	lesion	NNS
cord-022594-fx044gcd	443	36	,	,	,
cord-022594-fx044gcd	443	37	or	or	CC
cord-022594-fx044gcd	443	38	two	two	CD
cord-022594-fx044gcd	443	39	or	or	CC
cord-022594-fx044gcd	443	40	more	more	JJR
cord-022594-fx044gcd	443	41	cord	cord	NN
cord-022594-fx044gcd	443	42	lesions	lesion	NNS
cord-022594-fx044gcd	443	43	,	,	,
cord-022594-fx044gcd	443	44	or	or	CC
cord-022594-fx044gcd	443	45	four	four	CD
cord-022594-fx044gcd	443	46	to	to	TO
cord-022594-fx044gcd	443	47	eight	eight	CD
cord-022594-fx044gcd	443	48	brain	brain	NN
cord-022594-fx044gcd	443	49	lesions	lesion	NNS
cord-022594-fx044gcd	443	50	plus	plus	CC
cord-022594-fx044gcd	443	51	one	one	CD
cord-022594-fx044gcd	443	52	cord	cord	NN
cord-022594-fx044gcd	443	53	lesion	lesion	NN
cord-022594-fx044gcd	443	54	on	on	IN
cord-022594-fx044gcd	443	55	MRI	MRI	NNP
cord-022594-fx044gcd	443	56	.	.	.
cord-022594-fx044gcd	444	1	Alternatively	alternatively	RB
cord-022594-fx044gcd	444	2	,	,	,
cord-022594-fx044gcd	444	3	abnormal	abnormal	JJ
cord-022594-fx044gcd	444	4	visual	visual	JJ
cord-022594-fx044gcd	444	5	evoked	evoke	VBN
cord-022594-fx044gcd	444	6	potentials	potential	NNS
cord-022594-fx044gcd	444	7	(	(	-LRB-
cord-022594-fx044gcd	444	8	VEPs	vep	NNS
cord-022594-fx044gcd	444	9	)	)	-RRB-
cord-022594-fx044gcd	444	10	with	with	IN
cord-022594-fx044gcd	444	11	four	four	CD
cord-022594-fx044gcd	444	12	to	to	TO
cord-022594-fx044gcd	444	13	eight	eight	CD
cord-022594-fx044gcd	444	14	brain	brain	NN
cord-022594-fx044gcd	444	15	lesions	lesion	NNS
cord-022594-fx044gcd	444	16	,	,	,
cord-022594-fx044gcd	444	17	or	or	CC
cord-022594-fx044gcd	444	18	fewer	few	JJR
cord-022594-fx044gcd	444	19	than	than	IN
cord-022594-fx044gcd	444	20	four	four	CD
cord-022594-fx044gcd	444	21	brain	brain	NN
cord-022594-fx044gcd	444	22	lesions	lesion	NNS
cord-022594-fx044gcd	444	23	plus	plus	CC
cord-022594-fx044gcd	444	24	one	one	CD
cord-022594-fx044gcd	444	25	cord	cord	NN
cord-022594-fx044gcd	444	26	lesion	lesion	NN
cord-022594-fx044gcd	444	27	,	,	,
cord-022594-fx044gcd	444	28	and	and	CC
cord-022594-fx044gcd	444	29	dissemination	dissemination	NN
cord-022594-fx044gcd	444	30	in	in	IN
cord-022594-fx044gcd	444	31	time	time	NN
cord-022594-fx044gcd	444	32	on	on	IN
cord-022594-fx044gcd	444	33	serial	serial	JJ
cord-022594-fx044gcd	444	34	MRI	MRI	NNP
cord-022594-fx044gcd	444	35	scans	scan	NNS
cord-022594-fx044gcd	444	36	,	,	,
cord-022594-fx044gcd	444	37	or	or	CC
cord-022594-fx044gcd	444	38	continued	continue	VBN
cord-022594-fx044gcd	444	39	progression	progression	NN
cord-022594-fx044gcd	444	40	for	for	IN
cord-022594-fx044gcd	444	41	a	a	DT
cord-022594-fx044gcd	444	42	year	year	NN
cord-022594-fx044gcd	444	43	would	would	MD
cord-022594-fx044gcd	444	44	meet	meet	VB
cord-022594-fx044gcd	444	45	the	the	DT
cord-022594-fx044gcd	444	46	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	444	47	criteria	criterion	NNS
cord-022594-fx044gcd	444	48	.	.	.
cord-022594-fx044gcd	445	1	"	"	''
cord-022594-fx044gcd	446	1	Positive	positive	JJ
cord-022594-fx044gcd	446	2	CSF	csf	NN
cord-022594-fx044gcd	446	3	"	"	''
cord-022594-fx044gcd	447	1	according	accord	VBG
cord-022594-fx044gcd	447	2	to	to	IN
cord-022594-fx044gcd	447	3	this	this	DT
cord-022594-fx044gcd	447	4	set	set	NN
cord-022594-fx044gcd	447	5	of	of	IN
cord-022594-fx044gcd	447	6	criteria	criterion	NNS
cord-022594-fx044gcd	447	7	is	be	VBZ
cord-022594-fx044gcd	447	8	defined	define	VBN
cord-022594-fx044gcd	447	9	by	by	IN
cord-022594-fx044gcd	447	10	either	either	CC
cord-022594-fx044gcd	447	11	the	the	DT
cord-022594-fx044gcd	447	12	presence	presence	NN
cord-022594-fx044gcd	447	13	of	of	IN
cord-022594-fx044gcd	447	14	oligoclonal	oligoclonal	JJ
cord-022594-fx044gcd	447	15	bands	band	NNS
cord-022594-fx044gcd	447	16	detected	detect	VBN
cord-022594-fx044gcd	447	17	by	by	IN
cord-022594-fx044gcd	447	18	established	establish	VBN
cord-022594-fx044gcd	447	19	methods	method	NNS
cord-022594-fx044gcd	447	20	(	(	-LRB-
cord-022594-fx044gcd	447	21	preferably	preferably	RB
cord-022594-fx044gcd	447	22	isoelectric	isoelectric	JJ
cord-022594-fx044gcd	447	23	focusing	focus	VBG
cord-022594-fx044gcd	447	24	on	on	IN
cord-022594-fx044gcd	447	25	agarose	agarose	JJ
cord-022594-fx044gcd	447	26	gel	gel	NN
cord-022594-fx044gcd	447	27	followed	follow	VBN
cord-022594-fx044gcd	447	28	by	by	IN
cord-022594-fx044gcd	447	29	immunoblotting	immunoblotte	VBG
cord-022594-fx044gcd	447	30	)	)	-RRB-
cord-022594-fx044gcd	447	31	different	different	JJ
cord-022594-fx044gcd	447	32	from	from	IN
cord-022594-fx044gcd	447	33	any	any	DT
cord-022594-fx044gcd	447	34	such	such	JJ
cord-022594-fx044gcd	447	35	bands	band	NNS
cord-022594-fx044gcd	447	36	in	in	IN
cord-022594-fx044gcd	447	37	serum	serum	NN
cord-022594-fx044gcd	447	38	,	,	,
cord-022594-fx044gcd	447	39	or	or	CC
cord-022594-fx044gcd	447	40	by	by	IN
cord-022594-fx044gcd	447	41	a	a	DT
cord-022594-fx044gcd	447	42	raised	raise	VBN
cord-022594-fx044gcd	447	43	IgG	igg	NN
cord-022594-fx044gcd	447	44	index	index	NN
cord-022594-fx044gcd	447	45	.	.	.
cord-022594-fx044gcd	448	1	The	the	DT
cord-022594-fx044gcd	448	2	presence	presence	NN
cord-022594-fx044gcd	448	3	of	of	IN
cord-022594-fx044gcd	448	4	both	both	DT
cord-022594-fx044gcd	448	5	enhancing	enhance	VBG
cord-022594-fx044gcd	448	6	and	and	CC
cord-022594-fx044gcd	448	7	nonenhancing	nonenhance	VBG
cord-022594-fx044gcd	448	8	white	white	JJ
cord-022594-fx044gcd	448	9	matter	matter	NN
cord-022594-fx044gcd	448	10	lesions	lesion	NNS
cord-022594-fx044gcd	448	11	on	on	IN
cord-022594-fx044gcd	448	12	a	a	DT
cord-022594-fx044gcd	448	13	single	single	JJ
cord-022594-fx044gcd	448	14	MR	MR	NNP
cord-022594-fx044gcd	448	15	image	image	NN
cord-022594-fx044gcd	448	16	must	must	MD
cord-022594-fx044gcd	448	17	not	not	RB
cord-022594-fx044gcd	448	18	be	be	VB
cord-022594-fx044gcd	448	19	used	use	VBN
cord-022594-fx044gcd	448	20	as	as	IN
cord-022594-fx044gcd	448	21	evidence	evidence	NN
cord-022594-fx044gcd	448	22	of	of	IN
cord-022594-fx044gcd	448	23	dissemination	dissemination	NN
cord-022594-fx044gcd	448	24	in	in	IN
cord-022594-fx044gcd	448	25	time	time	NN
cord-022594-fx044gcd	448	26	as	as	RB
cord-022594-fx044gcd	448	27	well	well	RB
cord-022594-fx044gcd	448	28	as	as	IN
cord-022594-fx044gcd	448	29	space	space	NN
cord-022594-fx044gcd	448	30	,	,	,
cord-022594-fx044gcd	448	31	because	because	IN
cord-022594-fx044gcd	448	32	these	these	DT
cord-022594-fx044gcd	448	33	can	can	MD
cord-022594-fx044gcd	448	34	also	also	RB
cord-022594-fx044gcd	448	35	be	be	VB
cord-022594-fx044gcd	448	36	seen	see	VBN
cord-022594-fx044gcd	448	37	in	in	IN
cord-022594-fx044gcd	448	38	ADEM	ADEM	NNP
cord-022594-fx044gcd	448	39	.	.	.
cord-022594-fx044gcd	449	1	Oligoclonal	oligoclonal	JJ
cord-022594-fx044gcd	449	2	bands	band	NNS
cord-022594-fx044gcd	449	3	(	(	-LRB-
cord-022594-fx044gcd	449	4	OCBs	OCBs	NNP
cord-022594-fx044gcd	449	5	)	)	-RRB-
cord-022594-fx044gcd	449	6	and	and	CC
cord-022594-fx044gcd	449	7	an	an	DT
cord-022594-fx044gcd	449	8	elevated	elevated	JJ
cord-022594-fx044gcd	449	9	IgG	igg	NN
cord-022594-fx044gcd	449	10	index	index	NN
cord-022594-fx044gcd	449	11	provide	provide	VBP
cord-022594-fx044gcd	449	12	supportive	supportive	JJ
cord-022594-fx044gcd	449	13	CSF	CSF	NNP
cord-022594-fx044gcd	449	14	findings	finding	NNS
cord-022594-fx044gcd	449	15	.	.	.
cord-022594-fx044gcd	450	1	Ancillary	ancillary	JJ
cord-022594-fx044gcd	450	2	tests	test	NNS
cord-022594-fx044gcd	450	3	are	be	VBP
cord-022594-fx044gcd	450	4	frequently	frequently	RB
cord-022594-fx044gcd	450	5	required	require	VBN
cord-022594-fx044gcd	450	6	to	to	TO
cord-022594-fx044gcd	450	7	confirm	confirm	VB
cord-022594-fx044gcd	450	8	the	the	DT
cord-022594-fx044gcd	450	9	diagnosis	diagnosis	NN
cord-022594-fx044gcd	450	10	of	of	IN
cord-022594-fx044gcd	450	11	MS	MS	NNP
cord-022594-fx044gcd	450	12	and	and	CC
cord-022594-fx044gcd	450	13	to	to	TO
cord-022594-fx044gcd	450	14	exclude	exclude	VB
cord-022594-fx044gcd	450	15	other	other	JJ
cord-022594-fx044gcd	450	16	possibilities	possibility	NNS
cord-022594-fx044gcd	450	17	in	in	IN
cord-022594-fx044gcd	450	18	uncertain	uncertain	JJ
cord-022594-fx044gcd	450	19	cases	case	NNS
cord-022594-fx044gcd	450	20	.	.	.
cord-022594-fx044gcd	451	1	Laboratory	laboratory	NN
cord-022594-fx044gcd	451	2	tests	test	NNS
cord-022594-fx044gcd	451	3	on	on	IN
cord-022594-fx044gcd	451	4	peripheral	peripheral	JJ
cord-022594-fx044gcd	451	5	blood	blood	NN
cord-022594-fx044gcd	451	6	can	can	MD
cord-022594-fx044gcd	451	7	help	help	VB
cord-022594-fx044gcd	451	8	to	to	TO
cord-022594-fx044gcd	451	9	exclude	exclude	VB
cord-022594-fx044gcd	451	10	many	many	JJ
cord-022594-fx044gcd	451	11	of	of	IN
cord-022594-fx044gcd	451	12	the	the	DT
cord-022594-fx044gcd	451	13	infectious	infectious	JJ
cord-022594-fx044gcd	451	14	and	and	CC
cord-022594-fx044gcd	451	15	other	other	JJ
cord-022594-fx044gcd	451	16	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	451	17	disorders	disorder	NNS
cord-022594-fx044gcd	451	18	.	.	.
cord-022594-fx044gcd	452	1	A	a	DT
cord-022594-fx044gcd	452	2	chest	chest	NN
cord-022594-fx044gcd	452	3	x	x	NN
cord-022594-fx044gcd	452	4	-	-	NN
cord-022594-fx044gcd	452	5	ray	ray	NN
cord-022594-fx044gcd	452	6	is	be	VBZ
cord-022594-fx044gcd	452	7	generally	generally	RB
cord-022594-fx044gcd	452	8	needed	need	VBN
cord-022594-fx044gcd	452	9	to	to	TO
cord-022594-fx044gcd	452	10	assess	assess	VB
cord-022594-fx044gcd	452	11	for	for	IN
cord-022594-fx044gcd	452	12	sarcoid	sarcoid	NN
cord-022594-fx044gcd	452	13	or	or	CC
cord-022594-fx044gcd	452	14	paraneoplastic	paraneoplastic	JJ
cord-022594-fx044gcd	452	15	disorders	disorder	NNS
cord-022594-fx044gcd	452	16	if	if	IN
cord-022594-fx044gcd	452	17	these	these	DT
cord-022594-fx044gcd	452	18	are	be	VBP
cord-022594-fx044gcd	452	19	under	under	IN
cord-022594-fx044gcd	452	20	consideration	consideration	NN
cord-022594-fx044gcd	452	21	.	.	.
cord-022594-fx044gcd	453	1	An	an	DT
cord-022594-fx044gcd	453	2	ophthalmological	ophthalmological	JJ
cord-022594-fx044gcd	453	3	examination	examination	NN
cord-022594-fx044gcd	453	4	may	may	MD
cord-022594-fx044gcd	453	5	be	be	VB
cord-022594-fx044gcd	453	6	needed	need	VBN
cord-022594-fx044gcd	453	7	to	to	TO
cord-022594-fx044gcd	453	8	search	search	VB
cord-022594-fx044gcd	453	9	for	for	IN
cord-022594-fx044gcd	453	10	alternative	alternative	JJ
cord-022594-fx044gcd	453	11	causes	cause	NNS
cord-022594-fx044gcd	453	12	of	of	IN
cord-022594-fx044gcd	453	13	visual	visual	JJ
cord-022594-fx044gcd	453	14	loss	loss	NN
cord-022594-fx044gcd	453	15	.	.	.
cord-022594-fx044gcd	454	1	Imaging	imaging	NN
cord-022594-fx044gcd	454	2	studies	study	NNS
cord-022594-fx044gcd	454	3	,	,	,
cord-022594-fx044gcd	454	4	CSF	CSF	NNP
cord-022594-fx044gcd	454	5	examination	examination	NN
cord-022594-fx044gcd	454	6	,	,	,
cord-022594-fx044gcd	454	7	and	and	CC
cord-022594-fx044gcd	454	8	evoked	evoke	VBN
cord-022594-fx044gcd	454	9	potentials	potential	NNS
cord-022594-fx044gcd	454	10	are	be	VBP
cord-022594-fx044gcd	454	11	often	often	RB
cord-022594-fx044gcd	454	12	helpful	helpful	JJ
cord-022594-fx044gcd	454	13	because	because	IN
cord-022594-fx044gcd	454	14	characteristic	characteristic	JJ
cord-022594-fx044gcd	454	15	abnormalities	abnormality	NNS
cord-022594-fx044gcd	454	16	are	be	VBP
cord-022594-fx044gcd	454	17	frequently	frequently	RB
cord-022594-fx044gcd	454	18	present	present	JJ
cord-022594-fx044gcd	454	19	.	.	.
cord-022594-fx044gcd	455	1	MRI	MRI	NNP
cord-022594-fx044gcd	455	2	of	of	IN
cord-022594-fx044gcd	455	3	the	the	DT
cord-022594-fx044gcd	455	4	head	head	NN
cord-022594-fx044gcd	455	5	is	be	VBZ
cord-022594-fx044gcd	455	6	the	the	DT
cord-022594-fx044gcd	455	7	most	most	RBS
cord-022594-fx044gcd	455	8	sensitive	sensitive	JJ
cord-022594-fx044gcd	455	9	imaging	imaging	NN
cord-022594-fx044gcd	455	10	study	study	NN
cord-022594-fx044gcd	455	11	for	for	IN
cord-022594-fx044gcd	455	12	MS	MS	NNP
cord-022594-fx044gcd	455	13	(	(	-LRB-
cord-022594-fx044gcd	455	14	Fig	Fig	NNP
cord-022594-fx044gcd	455	15	.	.	.
cord-022594-fx044gcd	456	1	48	48	CD
cord-022594-fx044gcd	456	2	-	-	SYM
cord-022594-fx044gcd	456	3	3	3	CD
cord-022594-fx044gcd	456	4	)	)	-RRB-
cord-022594-fx044gcd	456	5	.	.	.
cord-022594-fx044gcd	457	1	Focal	focal	JJ
cord-022594-fx044gcd	457	2	areas	area	NNS
cord-022594-fx044gcd	457	3	of	of	IN
cord-022594-fx044gcd	457	4	increased	increase	VBN
cord-022594-fx044gcd	457	5	T2-weighted	t2-weighte	VBN
cord-022594-fx044gcd	457	6	and	and	CC
cord-022594-fx044gcd	457	7	decreased	decrease	VBD
cord-022594-fx044gcd	457	8	T1-weighted	t1-weighted	CD
cord-022594-fx044gcd	457	9	signal	signal	NN
cord-022594-fx044gcd	457	10	reflect	reflect	VBP
cord-022594-fx044gcd	457	11	the	the	DT
cord-022594-fx044gcd	457	12	increased	increased	JJ
cord-022594-fx044gcd	457	13	water	water	NN
cord-022594-fx044gcd	457	14	content	content	NN
cord-022594-fx044gcd	457	15	associated	associate	VBN
cord-022594-fx044gcd	457	16	with	with	IN
cord-022594-fx044gcd	457	17	demyelinated	demyelinate	VBN
cord-022594-fx044gcd	457	18	plaques	plaque	NNS
cord-022594-fx044gcd	457	19	.	.	.
cord-022594-fx044gcd	458	1	The	the	DT
cord-022594-fx044gcd	458	2	MRI	MRI	NNP
cord-022594-fx044gcd	458	3	appearance	appearance	NN
cord-022594-fx044gcd	458	4	of	of	IN
cord-022594-fx044gcd	458	5	MS	MS	NNP
cord-022594-fx044gcd	458	6	lesions	lesion	NNS
cord-022594-fx044gcd	458	7	,	,	,
cord-022594-fx044gcd	458	8	however	however	RB
cord-022594-fx044gcd	458	9	,	,	,
cord-022594-fx044gcd	458	10	is	be	VBZ
cord-022594-fx044gcd	458	11	not	not	RB
cord-022594-fx044gcd	458	12	specific	specific	JJ
cord-022594-fx044gcd	458	13	and	and	CC
cord-022594-fx044gcd	458	14	similar	similar	JJ
cord-022594-fx044gcd	458	15	abnormalities	abnormality	NNS
cord-022594-fx044gcd	458	16	may	may	MD
cord-022594-fx044gcd	458	17	be	be	VB
cord-022594-fx044gcd	458	18	seen	see	VBN
cord-022594-fx044gcd	458	19	in	in	IN
cord-022594-fx044gcd	458	20	normal	normal	JJ
cord-022594-fx044gcd	458	21	aging	age	VBG
cord-022594-fx044gcd	458	22	,	,	,
cord-022594-fx044gcd	458	23	small	small	JJ
cord-022594-fx044gcd	458	24	penetrating	penetrating	JJ
cord-022594-fx044gcd	458	25	vessel	vessel	NN
cord-022594-fx044gcd	458	26	infarcts	infarct	NNS
cord-022594-fx044gcd	458	27	,	,	,
cord-022594-fx044gcd	458	28	Lyme	Lyme	NNP
cord-022594-fx044gcd	458	29	disease	disease	NN
cord-022594-fx044gcd	458	30	,	,	,
cord-022594-fx044gcd	458	31	tropical	tropical	JJ
cord-022594-fx044gcd	458	32	spastic	spastic	JJ
cord-022594-fx044gcd	458	33	paraparesis	paraparesis	NN
cord-022594-fx044gcd	458	34	/	/	SYM
cord-022594-fx044gcd	458	35	HTLV-1-associated	htlv-1-associate	VBN
cord-022594-fx044gcd	459	1	myelopathy	myelopathy	NNP
cord-022594-fx044gcd	459	2	,	,	,
cord-022594-fx044gcd	459	3	sarcoid	sarcoid	NNP
cord-022594-fx044gcd	459	4	,	,	,
cord-022594-fx044gcd	459	5	systemic	systemic	JJ
cord-022594-fx044gcd	459	6	lupus	lupus	NN
cord-022594-fx044gcd	459	7	erythematosus	erythematosus	NN
cord-022594-fx044gcd	459	8	,	,	,
cord-022594-fx044gcd	459	9	Sjögren	Sjögren	NNP
cord-022594-fx044gcd	459	10	's	's	POS
cord-022594-fx044gcd	459	11	syndrome	syndrome	NN
cord-022594-fx044gcd	459	12	,	,	,
cord-022594-fx044gcd	459	13	mitochondrial	mitochondrial	JJ
cord-022594-fx044gcd	459	14	cytopathies	cytopathie	NNS
cord-022594-fx044gcd	459	15	,	,	,
cord-022594-fx044gcd	459	16	vasculitis	vasculitis	NN
cord-022594-fx044gcd	459	17	,	,	,
cord-022594-fx044gcd	459	18	and	and	CC
cord-022594-fx044gcd	459	19	ADEM	ADEM	NNP
cord-022594-fx044gcd	459	20	.	.	.
cord-022594-fx044gcd	460	1	The	the	DT
cord-022594-fx044gcd	460	2	specificity	specificity	NN
cord-022594-fx044gcd	460	3	for	for	IN
cord-022594-fx044gcd	460	4	MS	MS	NNP
cord-022594-fx044gcd	460	5	can	can	MD
cord-022594-fx044gcd	460	6	be	be	VB
cord-022594-fx044gcd	460	7	increased	increase	VBN
cord-022594-fx044gcd	460	8	by	by	IN
cord-022594-fx044gcd	460	9	consideration	consideration	NN
cord-022594-fx044gcd	460	10	of	of	IN
cord-022594-fx044gcd	460	11	lesion	lesion	NN
cord-022594-fx044gcd	460	12	number	number	NN
cord-022594-fx044gcd	460	13	,	,	,
cord-022594-fx044gcd	460	14	size	size	NN
cord-022594-fx044gcd	460	15	,	,	,
cord-022594-fx044gcd	460	16	location	location	NN
cord-022594-fx044gcd	460	17	,	,	,
cord-022594-fx044gcd	460	18	and	and	CC
cord-022594-fx044gcd	460	19	shape	shape	NN
cord-022594-fx044gcd	460	20	.	.	.
cord-022594-fx044gcd	461	1	45	45	CD
cord-022594-fx044gcd	462	1	This	this	DT
cord-022594-fx044gcd	462	2	is	be	VBZ
cord-022594-fx044gcd	462	3	especially	especially	RB
cord-022594-fx044gcd	462	4	important	important	JJ
cord-022594-fx044gcd	462	5	in	in	IN
cord-022594-fx044gcd	462	6	persons	person	NNS
cord-022594-fx044gcd	462	7	older	old	JJR
cord-022594-fx044gcd	462	8	than	than	IN
cord-022594-fx044gcd	462	9	age	age	NN
cord-022594-fx044gcd	462	10	50	50	CD
cord-022594-fx044gcd	462	11	.	.	.
cord-022594-fx044gcd	463	1	MRI	MRI	NNP
cord-022594-fx044gcd	463	2	characteristics	characteristic	NNS
cord-022594-fx044gcd	463	3	,	,	,
cord-022594-fx044gcd	463	4	other	other	JJ
cord-022594-fx044gcd	463	5	than	than	IN
cord-022594-fx044gcd	463	6	the	the	DT
cord-022594-fx044gcd	463	7	ones	one	NNS
cord-022594-fx044gcd	463	8	suggested	suggest	VBN
cord-022594-fx044gcd	463	9	by	by	IN
cord-022594-fx044gcd	463	10	the	the	DT
cord-022594-fx044gcd	463	11	international	international	JJ
cord-022594-fx044gcd	463	12	criteria	criterion	NNS
cord-022594-fx044gcd	463	13	outlined	outline	VBN
cord-022594-fx044gcd	463	14	previously	previously	RB
cord-022594-fx044gcd	463	15	,	,	,
cord-022594-fx044gcd	463	16	are	be	VBP
cord-022594-fx044gcd	463	17	size	size	NN
cord-022594-fx044gcd	463	18	larger	large	JJR
cord-022594-fx044gcd	463	19	than	than	IN
cord-022594-fx044gcd	463	20	6	6	CD
cord-022594-fx044gcd	463	21	mm	mm	NNS
cord-022594-fx044gcd	463	22	,	,	,
cord-022594-fx044gcd	463	23	oval	oval	JJ
cord-022594-fx044gcd	463	24	shape	shape	NN
cord-022594-fx044gcd	463	25	(	(	-LRB-
cord-022594-fx044gcd	463	26	often	often	RB
cord-022594-fx044gcd	463	27	with	with	IN
cord-022594-fx044gcd	463	28	the	the	DT
cord-022594-fx044gcd	463	29	long	long	JJ
cord-022594-fx044gcd	463	30	axis	axis	NN
cord-022594-fx044gcd	463	31	directed	direct	VBN
cord-022594-fx044gcd	463	32	perpendicular	perpendicular	JJ
cord-022594-fx044gcd	463	33	to	to	IN
cord-022594-fx044gcd	463	34	lateral	lateral	JJ
cord-022594-fx044gcd	463	35	ventricles	ventricle	NNS
cord-022594-fx044gcd	463	36	)	)	-RRB-
cord-022594-fx044gcd	463	37	,	,	,
cord-022594-fx044gcd	463	38	and	and	CC
cord-022594-fx044gcd	463	39	locations	location	NNS
cord-022594-fx044gcd	463	40	in	in	IN
cord-022594-fx044gcd	463	41	the	the	DT
cord-022594-fx044gcd	463	42	periventricular	periventricular	NNP
cord-022594-fx044gcd	463	43	area	area	NN
cord-022594-fx044gcd	463	44	,	,	,
cord-022594-fx044gcd	463	45	corpus	corpus	NNP
cord-022594-fx044gcd	463	46	callosum	callosum	NNP
cord-022594-fx044gcd	463	47	,	,	,
cord-022594-fx044gcd	463	48	and	and	CC
cord-022594-fx044gcd	463	49	posterior	posterior	JJ
cord-022594-fx044gcd	463	50	fossa	fossa	NN
cord-022594-fx044gcd	463	51	.	.	.
cord-022594-fx044gcd	464	1	Longitudinal	longitudinal	JJ
cord-022594-fx044gcd	464	2	MRI	MRI	NNP
cord-022594-fx044gcd	464	3	studies	study	NNS
cord-022594-fx044gcd	464	4	have	have	VBP
cord-022594-fx044gcd	464	5	shown	show	VBN
cord-022594-fx044gcd	464	6	the	the	DT
cord-022594-fx044gcd	464	7	evolution	evolution	NN
cord-022594-fx044gcd	464	8	of	of	IN
cord-022594-fx044gcd	464	9	MS	MS	NNP
cord-022594-fx044gcd	464	10	lesions	lesion	NNS
cord-022594-fx044gcd	464	11	.	.	.
cord-022594-fx044gcd	465	1	46	46	CD
cord-022594-fx044gcd	465	2	Gadolinium	Gadolinium	NNP
cord-022594-fx044gcd	465	3	enhancement	enhancement	NN
cord-022594-fx044gcd	465	4	,	,	,
cord-022594-fx044gcd	465	5	indicating	indicate	VBG
cord-022594-fx044gcd	465	6	blood	blood	NN
cord-022594-fx044gcd	465	7	-	-	HYPH
cord-022594-fx044gcd	465	8	brain	brain	NN
cord-022594-fx044gcd	465	9	barrier	barrier	NN
cord-022594-fx044gcd	465	10	disruption	disruption	NN
cord-022594-fx044gcd	465	11	,	,	,
cord-022594-fx044gcd	465	12	sometimes	sometimes	RB
cord-022594-fx044gcd	465	13	precedes	precede	VBZ
cord-022594-fx044gcd	465	14	the	the	DT
cord-022594-fx044gcd	465	15	development	development	NN
cord-022594-fx044gcd	465	16	of	of	IN
cord-022594-fx044gcd	465	17	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	465	18	lesions	lesion	NNS
cord-022594-fx044gcd	465	19	and	and	CC
cord-022594-fx044gcd	465	20	typically	typically	RB
cord-022594-fx044gcd	465	21	lasts	last	VBZ
cord-022594-fx044gcd	465	22	for	for	IN
cord-022594-fx044gcd	465	23	4	4	CD
cord-022594-fx044gcd	465	24	weeks	week	NNS
cord-022594-fx044gcd	465	25	in	in	IN
cord-022594-fx044gcd	465	26	the	the	DT
cord-022594-fx044gcd	465	27	brain	brain	NN
cord-022594-fx044gcd	465	28	(	(	-LRB-
cord-022594-fx044gcd	465	29	occasionally	occasionally	RB
cord-022594-fx044gcd	465	30	longer	long	RBR
cord-022594-fx044gcd	465	31	,	,	,
cord-022594-fx044gcd	465	32	especially	especially	RB
cord-022594-fx044gcd	465	33	in	in	IN
cord-022594-fx044gcd	465	34	larger	large	JJR
cord-022594-fx044gcd	465	35	hemispheric	hemispheric	JJ
cord-022594-fx044gcd	465	36	lesions	lesion	NNS
cord-022594-fx044gcd	465	37	)	)	-RRB-
cord-022594-fx044gcd	465	38	,	,	,
cord-022594-fx044gcd	465	39	and	and	CC
cord-022594-fx044gcd	465	40	perhaps	perhaps	RB
cord-022594-fx044gcd	465	41	somewhat	somewhat	RB
cord-022594-fx044gcd	465	42	longer	long	RBR
cord-022594-fx044gcd	465	43	in	in	IN
cord-022594-fx044gcd	465	44	the	the	DT
cord-022594-fx044gcd	465	45	spinal	spinal	JJ
cord-022594-fx044gcd	465	46	cord	cord	NN
cord-022594-fx044gcd	465	47	.	.	.
cord-022594-fx044gcd	466	1	FLAIR	flair	NN
cord-022594-fx044gcd	466	2	imaging	imaging	NN
cord-022594-fx044gcd	466	3	is	be	VBZ
cord-022594-fx044gcd	466	4	especially	especially	RB
cord-022594-fx044gcd	466	5	helpful	helpful	JJ
cord-022594-fx044gcd	466	6	for	for	IN
cord-022594-fx044gcd	466	7	evaluating	evaluate	VBG
cord-022594-fx044gcd	466	8	periventricular	periventricular	NNP
cord-022594-fx044gcd	466	9	lesions	lesion	NNS
cord-022594-fx044gcd	466	10	that	that	WDT
cord-022594-fx044gcd	466	11	may	may	MD
cord-022594-fx044gcd	466	12	go	go	VB
cord-022594-fx044gcd	466	13	unnoticed	unnoticed	JJ
cord-022594-fx044gcd	466	14	on	on	IN
cord-022594-fx044gcd	466	15	regular	regular	JJ
cord-022594-fx044gcd	466	16	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	466	17	scans	scan	NNS
cord-022594-fx044gcd	466	18	.	.	.
cord-022594-fx044gcd	467	1	The	the	DT
cord-022594-fx044gcd	467	2	disadvantage	disadvantage	NN
cord-022594-fx044gcd	467	3	of	of	IN
cord-022594-fx044gcd	467	4	the	the	DT
cord-022594-fx044gcd	467	5	technique	technique	NN
cord-022594-fx044gcd	467	6	is	be	VBZ
cord-022594-fx044gcd	467	7	its	-PRON-	PRP$
cord-022594-fx044gcd	467	8	relative	relative	JJ
cord-022594-fx044gcd	467	9	insensitivity	insensitivity	NN
cord-022594-fx044gcd	467	10	to	to	IN
cord-022594-fx044gcd	467	11	posterior	posterior	JJ
cord-022594-fx044gcd	467	12	fossa	fossa	NN
cord-022594-fx044gcd	467	13	lesions	lesion	NNS
cord-022594-fx044gcd	467	14	.	.	.
cord-022594-fx044gcd	468	1	Proton	proton	NN
cord-022594-fx044gcd	468	2	density	density	NN
cord-022594-fx044gcd	468	3	weighted	weight	VBN
cord-022594-fx044gcd	468	4	images	image	NNS
cord-022594-fx044gcd	468	5	are	be	VBP
cord-022594-fx044gcd	468	6	also	also	RB
cord-022594-fx044gcd	468	7	part	part	NN
cord-022594-fx044gcd	468	8	of	of	IN
cord-022594-fx044gcd	468	9	the	the	DT
cord-022594-fx044gcd	468	10	usual	usual	JJ
cord-022594-fx044gcd	468	11	sets	set	NNS
cord-022594-fx044gcd	468	12	of	of	IN
cord-022594-fx044gcd	468	13	images	image	NNS
cord-022594-fx044gcd	468	14	used	use	VBN
cord-022594-fx044gcd	468	15	in	in	IN
cord-022594-fx044gcd	468	16	the	the	DT
cord-022594-fx044gcd	468	17	MR	MR	NNP
cord-022594-fx044gcd	468	18	diagnostics	diagnostic	NNS
cord-022594-fx044gcd	468	19	of	of	IN
cord-022594-fx044gcd	468	20	MS	MS	NNP
cord-022594-fx044gcd	468	21	.	.	.
cord-022594-fx044gcd	469	1	These	these	DT
cord-022594-fx044gcd	469	2	images	image	NNS
cord-022594-fx044gcd	469	3	can	can	MD
cord-022594-fx044gcd	469	4	be	be	VB
cord-022594-fx044gcd	469	5	evaluated	evaluate	VBN
cord-022594-fx044gcd	469	6	similarly	similarly	RB
cord-022594-fx044gcd	469	7	to	to	IN
cord-022594-fx044gcd	469	8	T2-weighted	t2-weighte	VBN
cord-022594-fx044gcd	469	9	images	image	NNS
cord-022594-fx044gcd	469	10	.	.	.
cord-022594-fx044gcd	470	1	Technically	technically	RB
cord-022594-fx044gcd	470	2	,	,	,
cord-022594-fx044gcd	470	3	they	-PRON-	PRP
cord-022594-fx044gcd	470	4	are	be	VBP
cord-022594-fx044gcd	470	5	usually	usually	RB
cord-022594-fx044gcd	470	6	acquired	acquire	VBN
cord-022594-fx044gcd	470	7	together	together	RB
cord-022594-fx044gcd	470	8	with	with	IN
cord-022594-fx044gcd	470	9	the	the	DT
cord-022594-fx044gcd	470	10	T2-weighted	t2-weighte	VBN
cord-022594-fx044gcd	470	11	datasets	dataset	NNS
cord-022594-fx044gcd	470	12	,	,	,
cord-022594-fx044gcd	470	13	as	as	IN
cord-022594-fx044gcd	470	14	a	a	DT
cord-022594-fx044gcd	470	15	first	first	JJ
cord-022594-fx044gcd	470	16	echo	echo	NN
cord-022594-fx044gcd	470	17	in	in	IN
cord-022594-fx044gcd	470	18	conventional	conventional	JJ
cord-022594-fx044gcd	470	19	fast	fast	JJ
cord-022594-fx044gcd	470	20	spin	spin	NN
cord-022594-fx044gcd	470	21	echo	echo	NN
cord-022594-fx044gcd	470	22	sequences	sequence	NNS
cord-022594-fx044gcd	470	23	,	,	,
cord-022594-fx044gcd	470	24	where	where	WRB
cord-022594-fx044gcd	470	25	the	the	DT
cord-022594-fx044gcd	470	26	subsequent	subsequent	JJ
cord-022594-fx044gcd	470	27	echoes	echo	NNS
cord-022594-fx044gcd	470	28	can	can	MD
cord-022594-fx044gcd	470	29	be	be	VB
cord-022594-fx044gcd	470	30	used	use	VBN
cord-022594-fx044gcd	470	31	for	for	IN
cord-022594-fx044gcd	470	32	generating	generate	VBG
cord-022594-fx044gcd	470	33	the	the	DT
cord-022594-fx044gcd	470	34	T2-weighted	t2-weighte	VBN
cord-022594-fx044gcd	470	35	images	image	NNS
cord-022594-fx044gcd	470	36	.	.	.
cord-022594-fx044gcd	471	1	New	new	JJ
cord-022594-fx044gcd	471	2	T2weighted	t2weighted	JJ
cord-022594-fx044gcd	471	3	lesions	lesion	NNS
cord-022594-fx044gcd	471	4	have	have	VBP
cord-022594-fx044gcd	471	5	a	a	DT
cord-022594-fx044gcd	471	6	fuzzy	fuzzy	JJ
cord-022594-fx044gcd	471	7	border	border	NN
cord-022594-fx044gcd	471	8	and	and	CC
cord-022594-fx044gcd	471	9	enlarge	enlarge	VB
cord-022594-fx044gcd	471	10	over	over	IN
cord-022594-fx044gcd	471	11	a	a	DT
cord-022594-fx044gcd	471	12	few	few	JJ
cord-022594-fx044gcd	471	13	weeks	week	NNS
cord-022594-fx044gcd	471	14	.	.	.
cord-022594-fx044gcd	472	1	After	after	IN
cord-022594-fx044gcd	472	2	a	a	DT
cord-022594-fx044gcd	472	3	period	period	NN
cord-022594-fx044gcd	472	4	of	of	IN
cord-022594-fx044gcd	472	5	stabilization	stabilization	NN
cord-022594-fx044gcd	472	6	,	,	,
cord-022594-fx044gcd	472	7	the	the	DT
cord-022594-fx044gcd	472	8	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	472	9	lesion	lesion	NN
cord-022594-fx044gcd	472	10	regresses	regress	VBZ
cord-022594-fx044gcd	472	11	and	and	CC
cord-022594-fx044gcd	472	12	becomes	become	VBZ
cord-022594-fx044gcd	472	13	more	more	RBR
cord-022594-fx044gcd	472	14	sharply	sharply	RB
cord-022594-fx044gcd	472	15	delineated	delineate	VBN
cord-022594-fx044gcd	472	16	from	from	IN
cord-022594-fx044gcd	472	17	the	the	DT
cord-022594-fx044gcd	472	18	surrounding	surround	VBG
cord-022594-fx044gcd	472	19	white	white	JJ
cord-022594-fx044gcd	472	20	matter	matter	NN
cord-022594-fx044gcd	472	21	as	as	IN
cord-022594-fx044gcd	472	22	edema	edema	NN
cord-022594-fx044gcd	472	23	resolves	resolve	VBZ
cord-022594-fx044gcd	472	24	.	.	.
cord-022594-fx044gcd	473	1	Most	Most	JJS
cord-022594-fx044gcd	473	2	of	of	IN
cord-022594-fx044gcd	473	3	the	the	DT
cord-022594-fx044gcd	473	4	time	time	NN
cord-022594-fx044gcd	473	5	,	,	,
cord-022594-fx044gcd	473	6	a	a	DT
cord-022594-fx044gcd	473	7	residual	residual	JJ
cord-022594-fx044gcd	473	8	abnormality	abnormality	NN
cord-022594-fx044gcd	473	9	with	with	IN
cord-022594-fx044gcd	473	10	increased	increase	VBN
cord-022594-fx044gcd	473	11	T2	T2	NNP
cord-022594-fx044gcd	473	12	weighting	weighting	NN
cord-022594-fx044gcd	473	13	and	and	CC
cord-022594-fx044gcd	473	14	decreased	decrease	VBD
cord-022594-fx044gcd	473	15	T1-weighted	t1-weighte	VBN
cord-022594-fx044gcd	473	16	signal	signal	NN
cord-022594-fx044gcd	473	17	remains	remain	VBZ
cord-022594-fx044gcd	473	18	,	,	,
cord-022594-fx044gcd	473	19	reflecting	reflect	VBG
cord-022594-fx044gcd	473	20	demyelination	demyelination	NN
cord-022594-fx044gcd	473	21	and	and	CC
cord-022594-fx044gcd	473	22	gliosis	gliosis	NN
cord-022594-fx044gcd	473	23	.	.	.
cord-022594-fx044gcd	474	1	The	the	DT
cord-022594-fx044gcd	474	2	low	low	JJ
cord-022594-fx044gcd	474	3	attenuation	attenuation	NN
cord-022594-fx044gcd	474	4	T1	t1	NN
cord-022594-fx044gcd	474	5	signal	signal	NN
cord-022594-fx044gcd	474	6	,	,	,
cord-022594-fx044gcd	474	7	or	or	CC
cord-022594-fx044gcd	474	8	"	"	``
cord-022594-fx044gcd	474	9	T1	T1	NNP
cord-022594-fx044gcd	474	10	black	black	JJ
cord-022594-fx044gcd	474	11	hole	hole	NN
cord-022594-fx044gcd	474	12	,	,	,
cord-022594-fx044gcd	474	13	"	"	''
cord-022594-fx044gcd	474	14	is	be	VBZ
cord-022594-fx044gcd	474	15	more	more	RBR
cord-022594-fx044gcd	474	16	often	often	RB
cord-022594-fx044gcd	474	17	seen	see	VBN
cord-022594-fx044gcd	474	18	in	in	IN
cord-022594-fx044gcd	474	19	secondary	secondary	JJ
cord-022594-fx044gcd	474	20	progressive	progressive	JJ
cord-022594-fx044gcd	474	21	MS	MS	NNP
cord-022594-fx044gcd	474	22	and	and	CC
cord-022594-fx044gcd	474	23	is	be	VBZ
cord-022594-fx044gcd	474	24	thought	think	VBN
cord-022594-fx044gcd	474	25	to	to	TO
cord-022594-fx044gcd	474	26	represent	represent	VB
cord-022594-fx044gcd	474	27	actual	actual	JJ
cord-022594-fx044gcd	474	28	tissue	tissue	NN
cord-022594-fx044gcd	474	29	loss	loss	NN
cord-022594-fx044gcd	474	30	.	.	.
cord-022594-fx044gcd	475	1	In	in	IN
cord-022594-fx044gcd	475	2	several	several	JJ
cord-022594-fx044gcd	475	3	well	well	RB
cord-022594-fx044gcd	475	4	-	-	HYPH
cord-022594-fx044gcd	475	5	documented	document	VBN
cord-022594-fx044gcd	475	6	cases	case	NNS
cord-022594-fx044gcd	475	7	,	,	,
cord-022594-fx044gcd	475	8	hypointense	hypointense	NN
cord-022594-fx044gcd	475	9	lesions	lesion	NNS
cord-022594-fx044gcd	475	10	on	on	IN
cord-022594-fx044gcd	475	11	T2-weighted	t2-weighte	VBN
cord-022594-fx044gcd	475	12	scans	scan	NNS
cord-022594-fx044gcd	475	13	were	be	VBD
cord-022594-fx044gcd	475	14	described	describe	VBN
cord-022594-fx044gcd	475	15	in	in	IN
cord-022594-fx044gcd	475	16	subcortical	subcortical	JJ
cord-022594-fx044gcd	475	17	gray	gray	JJ
cord-022594-fx044gcd	475	18	matter	matter	NN
cord-022594-fx044gcd	475	19	structures	structure	NNS
cord-022594-fx044gcd	475	20	in	in	IN
cord-022594-fx044gcd	475	21	MS	MS	NNP
cord-022594-fx044gcd	475	22	patients	patient	NNS
cord-022594-fx044gcd	475	23	.	.	.
cord-022594-fx044gcd	476	1	On	on	IN
cord-022594-fx044gcd	476	2	a	a	DT
cord-022594-fx044gcd	476	3	molecular	molecular	JJ
cord-022594-fx044gcd	476	4	level	level	NN
cord-022594-fx044gcd	476	5	these	these	DT
cord-022594-fx044gcd	476	6	areas	area	NNS
cord-022594-fx044gcd	476	7	are	be	VBP
cord-022594-fx044gcd	476	8	thought	think	VBN
cord-022594-fx044gcd	476	9	to	to	TO
cord-022594-fx044gcd	476	10	represent	represent	VB
cord-022594-fx044gcd	476	11	iron	iron	NN
cord-022594-fx044gcd	476	12	deposition	deposition	NN
cord-022594-fx044gcd	476	13	;	;	:
cord-022594-fx044gcd	476	14	their	-PRON-	PRP$
cord-022594-fx044gcd	476	15	significance	significance	NN
cord-022594-fx044gcd	476	16	in	in	IN
cord-022594-fx044gcd	476	17	MS	MS	NNP
cord-022594-fx044gcd	476	18	is	be	VBZ
cord-022594-fx044gcd	476	19	not	not	RB
cord-022594-fx044gcd	476	20	fully	fully	RB
cord-022594-fx044gcd	476	21	understood	understand	VBN
cord-022594-fx044gcd	476	22	.	.	.
cord-022594-fx044gcd	477	1	The	the	DT
cord-022594-fx044gcd	477	2	MRI	MRI	NNP
cord-022594-fx044gcd	477	3	activity	activity	NN
cord-022594-fx044gcd	477	4	of	of	IN
cord-022594-fx044gcd	477	5	disease	disease	NN
cord-022594-fx044gcd	477	6	,	,	,
cord-022594-fx044gcd	477	7	defined	define	VBN
cord-022594-fx044gcd	477	8	as	as	IN
cord-022594-fx044gcd	477	9	either	either	CC
cord-022594-fx044gcd	477	10	the	the	DT
cord-022594-fx044gcd	477	11	number	number	NN
cord-022594-fx044gcd	477	12	of	of	IN
cord-022594-fx044gcd	477	13	new	new	JJ
cord-022594-fx044gcd	477	14	,	,	,
cord-022594-fx044gcd	477	15	recurrent	recurrent	JJ
cord-022594-fx044gcd	477	16	,	,	,
cord-022594-fx044gcd	477	17	and	and	CC
cord-022594-fx044gcd	477	18	enlarging	enlarge	VBG
cord-022594-fx044gcd	477	19	lesions	lesion	NNS
cord-022594-fx044gcd	477	20	or	or	CC
cord-022594-fx044gcd	477	21	the	the	DT
cord-022594-fx044gcd	477	22	number	number	NN
cord-022594-fx044gcd	477	23	of	of	IN
cord-022594-fx044gcd	477	24	gadolinium	gadolinium	NN
cord-022594-fx044gcd	477	25	-	-	HYPH
cord-022594-fx044gcd	477	26	enhancing	enhance	VBG
cord-022594-fx044gcd	477	27	lesions	lesion	NNS
cord-022594-fx044gcd	477	28	,	,	,
cord-022594-fx044gcd	477	29	is	be	VBZ
cord-022594-fx044gcd	477	30	usually	usually	RB
cord-022594-fx044gcd	477	31	higher	high	JJR
cord-022594-fx044gcd	477	32	than	than	IN
cord-022594-fx044gcd	477	33	the	the	DT
cord-022594-fx044gcd	477	34	clinical	clinical	JJ
cord-022594-fx044gcd	477	35	activity	activity	NN
cord-022594-fx044gcd	477	36	.	.	.
cord-022594-fx044gcd	478	1	This	this	DT
cord-022594-fx044gcd	478	2	may	may	MD
cord-022594-fx044gcd	478	3	be	be	VB
cord-022594-fx044gcd	478	4	either	either	CC
cord-022594-fx044gcd	478	5	because	because	IN
cord-022594-fx044gcd	478	6	of	of	IN
cord-022594-fx044gcd	478	7	the	the	DT
cord-022594-fx044gcd	478	8	involvement	involvement	NN
cord-022594-fx044gcd	478	9	of	of	IN
cord-022594-fx044gcd	478	10	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	478	11	areas	area	NNS
cord-022594-fx044gcd	478	12	of	of	IN
cord-022594-fx044gcd	478	13	the	the	DT
cord-022594-fx044gcd	478	14	CNS	CNS	NNP
cord-022594-fx044gcd	478	15	or	or	CC
cord-022594-fx044gcd	478	16	because	because	IN
cord-022594-fx044gcd	478	17	of	of	IN
cord-022594-fx044gcd	478	18	a	a	DT
cord-022594-fx044gcd	478	19	pathophysiological	pathophysiological	JJ
cord-022594-fx044gcd	478	20	difference	difference	NN
cord-022594-fx044gcd	478	21	between	between	IN
cord-022594-fx044gcd	478	22	symptomatic	symptomatic	JJ
cord-022594-fx044gcd	478	23	and	and	CC
cord-022594-fx044gcd	478	24	nonsymptomatic	nonsymptomatic	JJ
cord-022594-fx044gcd	478	25	lesions	lesion	NNS
cord-022594-fx044gcd	478	26	based	base	VBN
cord-022594-fx044gcd	478	27	on	on	IN
cord-022594-fx044gcd	478	28	the	the	DT
cord-022594-fx044gcd	478	29	presence	presence	NN
cord-022594-fx044gcd	478	30	or	or	CC
cord-022594-fx044gcd	478	31	absence	absence	NN
cord-022594-fx044gcd	478	32	of	of	IN
cord-022594-fx044gcd	478	33	axonal	axonal	JJ
cord-022594-fx044gcd	478	34	dysfunction	dysfunction	NN
cord-022594-fx044gcd	478	35	.	.	.
cord-022594-fx044gcd	479	1	There	there	EX
cord-022594-fx044gcd	479	2	is	be	VBZ
cord-022594-fx044gcd	479	3	only	only	RB
cord-022594-fx044gcd	479	4	poor	poor	JJ
cord-022594-fx044gcd	479	5	correlation	correlation	NN
cord-022594-fx044gcd	479	6	between	between	IN
cord-022594-fx044gcd	479	7	disability	disability	NN
cord-022594-fx044gcd	479	8	and	and	CC
cord-022594-fx044gcd	479	9	lesion	lesion	NN
cord-022594-fx044gcd	479	10	load	load	NN
cord-022594-fx044gcd	479	11	(	(	-LRB-
cord-022594-fx044gcd	479	12	volume	volume	NN
cord-022594-fx044gcd	479	13	of	of	IN
cord-022594-fx044gcd	479	14	white	white	JJ
cord-022594-fx044gcd	479	15	matter	matter	NN
cord-022594-fx044gcd	479	16	abnormalities	abnormality	NNS
cord-022594-fx044gcd	479	17	)	)	-RRB-
cord-022594-fx044gcd	479	18	determined	determine	VBN
cord-022594-fx044gcd	479	19	by	by	IN
cord-022594-fx044gcd	479	20	head	head	NN
cord-022594-fx044gcd	479	21	MRI	MRI	NNP
cord-022594-fx044gcd	479	22	.	.	.
cord-022594-fx044gcd	480	1	Sometimes	sometimes	RB
cord-022594-fx044gcd	480	2	individuals	individual	NNS
cord-022594-fx044gcd	480	3	have	have	VBP
cord-022594-fx044gcd	480	4	severe	severe	JJ
cord-022594-fx044gcd	480	5	impairment	impairment	NN
cord-022594-fx044gcd	480	6	and	and	CC
cord-022594-fx044gcd	480	7	few	few	JJ
cord-022594-fx044gcd	480	8	MRI	MRI	NNP
cord-022594-fx044gcd	480	9	abnormalities	abnormality	NNS
cord-022594-fx044gcd	480	10	,	,	,
cord-022594-fx044gcd	480	11	and	and	CC
cord-022594-fx044gcd	480	12	the	the	DT
cord-022594-fx044gcd	480	13	converse	converse	NN
cord-022594-fx044gcd	480	14	may	may	MD
cord-022594-fx044gcd	480	15	occur	occur	VB
cord-022594-fx044gcd	480	16	.	.	.
cord-022594-fx044gcd	481	1	This	this	DT
cord-022594-fx044gcd	481	2	disparity	disparity	NN
cord-022594-fx044gcd	481	3	is	be	VBZ
cord-022594-fx044gcd	481	4	partially	partially	RB
cord-022594-fx044gcd	481	5	explained	explain	VBN
cord-022594-fx044gcd	481	6	by	by	IN
cord-022594-fx044gcd	481	7	variable	variable	JJ
cord-022594-fx044gcd	481	8	spinal	spinal	JJ
cord-022594-fx044gcd	481	9	cord	cord	NN
cord-022594-fx044gcd	481	10	involvement	involvement	NN
cord-022594-fx044gcd	481	11	,	,	,
cord-022594-fx044gcd	481	12	but	but	CC
cord-022594-fx044gcd	481	13	a	a	DT
cord-022594-fx044gcd	481	14	pathophysiological	pathophysiological	JJ
cord-022594-fx044gcd	481	15	difference	difference	NN
cord-022594-fx044gcd	481	16	may	may	MD
cord-022594-fx044gcd	481	17	account	account	VB
cord-022594-fx044gcd	481	18	for	for	IN
cord-022594-fx044gcd	481	19	some	some	DT
cord-022594-fx044gcd	481	20	of	of	IN
cord-022594-fx044gcd	481	21	the	the	DT
cord-022594-fx044gcd	481	22	discrepancy	discrepancy	NN
cord-022594-fx044gcd	481	23	.	.	.
cord-022594-fx044gcd	482	1	Several	several	JJ
cord-022594-fx044gcd	482	2	MRI	MRI	NNP
cord-022594-fx044gcd	482	3	markers	marker	NNS
cord-022594-fx044gcd	482	4	of	of	IN
cord-022594-fx044gcd	482	5	gray	gray	JJ
cord-022594-fx044gcd	482	6	matter	matter	NN
cord-022594-fx044gcd	482	7	involvement	involvement	NN
cord-022594-fx044gcd	482	8	correlate	correlate	VBP
cord-022594-fx044gcd	482	9	better	well	RBR
cord-022594-fx044gcd	482	10	than	than	IN
cord-022594-fx044gcd	482	11	measures	measure	NNS
cord-022594-fx044gcd	482	12	of	of	IN
cord-022594-fx044gcd	482	13	white	white	JJ
cord-022594-fx044gcd	482	14	matter	matter	NN
cord-022594-fx044gcd	482	15	pathology	pathology	NN
cord-022594-fx044gcd	482	16	with	with	IN
cord-022594-fx044gcd	482	17	clinical	clinical	JJ
cord-022594-fx044gcd	482	18	functional	functional	JJ
cord-022594-fx044gcd	482	19	outcome	outcome	NN
cord-022594-fx044gcd	482	20	measures	measure	NNS
cord-022594-fx044gcd	482	21	in	in	IN
cord-022594-fx044gcd	482	22	MS	MS	NNP
cord-022594-fx044gcd	482	23	.	.	.
cord-022594-fx044gcd	483	1	In	in	IN
cord-022594-fx044gcd	483	2	a	a	DT
cord-022594-fx044gcd	483	3	recent	recent	JJ
cord-022594-fx044gcd	483	4	study	study	NN
cord-022594-fx044gcd	483	5	47	47	CD
cord-022594-fx044gcd	483	6	EDSS	EDSS	NNP
cord-022594-fx044gcd	483	7	showed	show	VBD
cord-022594-fx044gcd	483	8	the	the	DT
cord-022594-fx044gcd	483	9	strongest	strong	JJS
cord-022594-fx044gcd	483	10	correlation	correlation	NN
cord-022594-fx044gcd	483	11	with	with	IN
cord-022594-fx044gcd	483	12	gray	gray	JJ
cord-022594-fx044gcd	483	13	matter	matter	NN
cord-022594-fx044gcd	483	14	volume	volume	NN
cord-022594-fx044gcd	483	15	loss	loss	NN
cord-022594-fx044gcd	483	16	and	and	CC
cord-022594-fx044gcd	483	17	with	with	IN
cord-022594-fx044gcd	483	18	T1	T1	NNP
cord-022594-fx044gcd	483	19	black	black	JJ
cord-022594-fx044gcd	483	20	hole	hole	NN
cord-022594-fx044gcd	483	21	volume	volume	NN
cord-022594-fx044gcd	483	22	increase	increase	NN
cord-022594-fx044gcd	484	1	(	(	-LRB-
cord-022594-fx044gcd	484	2	p	p	NN
cord-022594-fx044gcd	484	3	<	<	XX
cord-022594-fx044gcd	484	4	0.01	0.01	CD
cord-022594-fx044gcd	484	5	)	)	-RRB-
cord-022594-fx044gcd	484	6	;	;	:
cord-022594-fx044gcd	484	7	both	both	DT
cord-022594-fx044gcd	484	8	are	be	VBP
cord-022594-fx044gcd	484	9	considered	consider	VBN
cord-022594-fx044gcd	484	10	to	to	TO
cord-022594-fx044gcd	484	11	reflect	reflect	VB
cord-022594-fx044gcd	484	12	neuronal	neuronal	JJ
cord-022594-fx044gcd	484	13	and	and	CC
cord-022594-fx044gcd	484	14	axonal	axonal	JJ
cord-022594-fx044gcd	484	15	pathology	pathology	NN
cord-022594-fx044gcd	484	16	.	.	.
cord-022594-fx044gcd	485	1	Ambulatory	ambulatory	JJ
cord-022594-fx044gcd	485	2	function	function	NN
cord-022594-fx044gcd	485	3	,	,	,
cord-022594-fx044gcd	485	4	assessed	assess	VBN
cord-022594-fx044gcd	485	5	as	as	IN
cord-022594-fx044gcd	485	6	the	the	DT
cord-022594-fx044gcd	485	7	25-feet	25-feet	CD
cord-022594-fx044gcd	485	8	timed	time	VBN
cord-022594-fx044gcd	485	9	walk	walk	NN
cord-022594-fx044gcd	485	10	,	,	,
cord-022594-fx044gcd	485	11	also	also	RB
cord-022594-fx044gcd	485	12	correlated	correlate	VBD
cord-022594-fx044gcd	485	13	well	well	RB
cord-022594-fx044gcd	485	14	with	with	IN
cord-022594-fx044gcd	485	15	gray	gray	JJ
cord-022594-fx044gcd	485	16	matter	matter	NNP
cord-022594-fx044gcd	485	17	volume	volume	NN
cord-022594-fx044gcd	485	18	loss	loss	NN
cord-022594-fx044gcd	485	19	and	and	CC
cord-022594-fx044gcd	485	20	T1	T1	NNP
cord-022594-fx044gcd	485	21	black	black	JJ
cord-022594-fx044gcd	485	22	hole	hole	NN
cord-022594-fx044gcd	485	23	volume	volume	NN
cord-022594-fx044gcd	485	24	.	.	.
cord-022594-fx044gcd	486	1	On	on	IN
cord-022594-fx044gcd	486	2	normal	normal	JJ
cord-022594-fx044gcd	486	3	appearing	appear	VBG
cord-022594-fx044gcd	486	4	gray	gray	JJ
cord-022594-fx044gcd	486	5	matter	matter	NN
cord-022594-fx044gcd	486	6	magnetization	magnetization	NN
cord-022594-fx044gcd	486	7	transfer	transfer	NN
cord-022594-fx044gcd	486	8	ratio	ratio	NN
cord-022594-fx044gcd	486	9	(	(	-LRB-
cord-022594-fx044gcd	486	10	MTR	MTR	NNP
cord-022594-fx044gcd	486	11	)	)	-RRB-
cord-022594-fx044gcd	486	12	histograms	histogram	NNS
cord-022594-fx044gcd	486	13	,	,	,
cord-022594-fx044gcd	486	14	normalized	normalize	VBN
cord-022594-fx044gcd	486	15	peak	peak	NN
cord-022594-fx044gcd	486	16	heights	height	NNS
cord-022594-fx044gcd	486	17	inversely	inversely	RB
cord-022594-fx044gcd	486	18	correlated	correlate	VBD
cord-022594-fx044gcd	486	19	with	with	IN
cord-022594-fx044gcd	486	20	EDSS	EDSS	NNP
cord-022594-fx044gcd	486	21	in	in	IN
cord-022594-fx044gcd	486	22	18	18	CD
cord-022594-fx044gcd	486	23	RRMS	RRMS	NNP
cord-022594-fx044gcd	486	24	patients	patient	NNS
cord-022594-fx044gcd	486	25	(	(	-LRB-
cord-022594-fx044gcd	486	26	r	r	NNP
cord-022594-fx044gcd	486	27	¼	¼	NNP
cord-022594-fx044gcd	486	28	À0.65	À0.65	NNP
cord-022594-fx044gcd	486	29	,	,	,
cord-022594-fx044gcd	486	30	p	p	NNP
cord-022594-fx044gcd	486	31	¼.01	¼.01	NNP
cord-022594-fx044gcd	486	32	)	)	-RRB-
cord-022594-fx044gcd	486	33	.	.	.
cord-022594-fx044gcd	487	1	48	48	CD
cord-022594-fx044gcd	488	1	In	in	IN
cord-022594-fx044gcd	488	2	a	a	DT
cord-022594-fx044gcd	488	3	study	study	NN
cord-022594-fx044gcd	488	4	evaluating	evaluate	VBG
cord-022594-fx044gcd	488	5	a	a	DT
cord-022594-fx044gcd	488	6	number	number	NN
cord-022594-fx044gcd	488	7	of	of	IN
cord-022594-fx044gcd	488	8	MRI	MRI	NNP
cord-022594-fx044gcd	488	9	parameters	parameter	NNS
cord-022594-fx044gcd	488	10	(	(	-LRB-
cord-022594-fx044gcd	488	11	including	include	VBG
cord-022594-fx044gcd	488	12	brain	brain	NN
cord-022594-fx044gcd	488	13	T1-hypointense	t1-hypointense	NN
cord-022594-fx044gcd	488	14	and	and	CC
cord-022594-fx044gcd	488	15	FLAIR	flair	NN
cord-022594-fx044gcd	488	16	-	-	HYPH
cord-022594-fx044gcd	488	17	hyperintense	hyperintense	NN
cord-022594-fx044gcd	488	18	lesion	lesion	NN
cord-022594-fx044gcd	488	19	volume	volume	NN
cord-022594-fx044gcd	488	20	,	,	,
cord-022594-fx044gcd	488	21	third	third	JJ
cord-022594-fx044gcd	488	22	ventricle	ventricle	NN
cord-022594-fx044gcd	488	23	width	width	NN
cord-022594-fx044gcd	488	24	,	,	,
cord-022594-fx044gcd	488	25	brain	brain	NN
cord-022594-fx044gcd	488	26	parenchymal	parenchymal	NN
cord-022594-fx044gcd	488	27	fraction	fraction	NN
cord-022594-fx044gcd	488	28	and	and	CC
cord-022594-fx044gcd	488	29	T2	T2	NNP
cord-022594-fx044gcd	488	30	hypointensities	hypointensitie	NNS
cord-022594-fx044gcd	488	31	in	in	IN
cord-022594-fx044gcd	488	32	the	the	DT
cord-022594-fx044gcd	488	33	dentate	dentate	JJ
cord-022594-fx044gcd	488	34	nucleus	nucleus	NN
cord-022594-fx044gcd	488	35	)	)	-RRB-
cord-022594-fx044gcd	488	36	,	,	,
cord-022594-fx044gcd	488	37	the	the	DT
cord-022594-fx044gcd	488	38	best	good	JJS
cord-022594-fx044gcd	488	39	correlation	correlation	NN
cord-022594-fx044gcd	488	40	with	with	IN
cord-022594-fx044gcd	488	41	EDSS	EDSS	NNP
cord-022594-fx044gcd	488	42	(	(	-LRB-
cord-022594-fx044gcd	488	43	and	and	CC
cord-022594-fx044gcd	488	44	the	the	DT
cord-022594-fx044gcd	488	45	only	only	JJ
cord-022594-fx044gcd	488	46	correlating	correlate	VBG
cord-022594-fx044gcd	488	47	parameter	parameter	NN
cord-022594-fx044gcd	488	48	with	with	IN
cord-022594-fx044gcd	488	49	25-feet	25-feet	CD
cord-022594-fx044gcd	488	50	timed	time	VBN
cord-022594-fx044gcd	488	51	walk	walk	NN
cord-022594-fx044gcd	488	52	)	)	-RRB-
cord-022594-fx044gcd	488	53	was	be	VBD
cord-022594-fx044gcd	488	54	T2	T2	NNP
cord-022594-fx044gcd	488	55	hypointensity	hypointensity	NN
cord-022594-fx044gcd	488	56	in	in	IN
cord-022594-fx044gcd	488	57	the	the	DT
cord-022594-fx044gcd	488	58	dentate	dentate	JJ
cord-022594-fx044gcd	488	59	nucleus	nucleus	NN
cord-022594-fx044gcd	488	60	.	.	.
cord-022594-fx044gcd	489	1	49	49	CD
cord-022594-fx044gcd	490	1	In	in	IN
cord-022594-fx044gcd	490	2	41	41	CD
cord-022594-fx044gcd	490	3	MS	MS	NNP
cord-022594-fx044gcd	490	4	patients	patient	NNS
cord-022594-fx044gcd	490	5	,	,	,
cord-022594-fx044gcd	490	6	an	an	DT
cord-022594-fx044gcd	490	7	MRI	MRI	NNP
cord-022594-fx044gcd	490	8	study	study	NN
cord-022594-fx044gcd	490	9	concluded	conclude	VBD
cord-022594-fx044gcd	490	10	that	that	IN
cord-022594-fx044gcd	490	11	gray	gray	JJ
cord-022594-fx044gcd	490	12	matter	matter	NN
cord-022594-fx044gcd	490	13	atrophy	atrophy	NN
cord-022594-fx044gcd	490	14	correlated	correlate	VBN
cord-022594-fx044gcd	490	15	with	with	IN
cord-022594-fx044gcd	490	16	clinical	clinical	JJ
cord-022594-fx044gcd	490	17	status	status	NN
cord-022594-fx044gcd	490	18	(	(	-LRB-
cord-022594-fx044gcd	490	19	EDSS	EDSS	NNP
cord-022594-fx044gcd	490	20	,	,	,
cord-022594-fx044gcd	490	21	25-feet	25-feet	CD
cord-022594-fx044gcd	490	22	timed	time	VBD
cord-022594-fx044gcd	490	23	walking	walking	NN
cord-022594-fx044gcd	490	24	and	and	CC
cord-022594-fx044gcd	490	25	disease	disease	NN
cord-022594-fx044gcd	490	26	duration	duration	NN
cord-022594-fx044gcd	490	27	)	)	-RRB-
cord-022594-fx044gcd	490	28	.	.	.
cord-022594-fx044gcd	491	1	47	47	CD
cord-022594-fx044gcd	492	1	A	a	DT
cord-022594-fx044gcd	492	2	study	study	NN
cord-022594-fx044gcd	492	3	of	of	IN
cord-022594-fx044gcd	492	4	patients	patient	NNS
cord-022594-fx044gcd	492	5	with	with	IN
cord-022594-fx044gcd	492	6	PPMS	PPMS	NNP
cord-022594-fx044gcd	492	7	and	and	CC
cord-022594-fx044gcd	492	8	RRMS	RRMS	NNP
cord-022594-fx044gcd	492	9	showed	show	VBD
cord-022594-fx044gcd	492	10	that	that	IN
cord-022594-fx044gcd	492	11	neocortical	neocortical	JJ
cord-022594-fx044gcd	492	12	volume	volume	NN
cord-022594-fx044gcd	492	13	as	as	IN
cord-022594-fx044gcd	492	14	determined	determine	VBN
cord-022594-fx044gcd	492	15	by	by	IN
cord-022594-fx044gcd	492	16	MRI	MRI	NNP
cord-022594-fx044gcd	492	17	correlated	correlate	VBN
cord-022594-fx044gcd	492	18	with	with	IN
cord-022594-fx044gcd	492	19	EDSS	EDSS	NNP
cord-022594-fx044gcd	492	20	scores	score	NNS
cord-022594-fx044gcd	492	21	across	across	IN
cord-022594-fx044gcd	492	22	all	all	PDT
cord-022594-fx044gcd	492	23	the	the	DT
cord-022594-fx044gcd	492	24	patients	patient	NNS
cord-022594-fx044gcd	492	25	,	,	,
cord-022594-fx044gcd	492	26	but	but	CC
cord-022594-fx044gcd	492	27	the	the	DT
cord-022594-fx044gcd	492	28	strength	strength	NN
cord-022594-fx044gcd	492	29	of	of	IN
cord-022594-fx044gcd	492	30	the	the	DT
cord-022594-fx044gcd	492	31	correlation	correlation	NN
cord-022594-fx044gcd	492	32	was	be	VBD
cord-022594-fx044gcd	492	33	stronger	strong	JJR
cord-022594-fx044gcd	492	34	(	(	-LRB-
cord-022594-fx044gcd	492	35	p	p	NN
cord-022594-fx044gcd	492	36	<	<	XX
cord-022594-fx044gcd	492	37	0.05	0.05	CD
cord-022594-fx044gcd	492	38	)	)	-RRB-
cord-022594-fx044gcd	492	39	in	in	IN
cord-022594-fx044gcd	492	40	the	the	DT
cord-022594-fx044gcd	492	41	PPMS	PPMS	NNP
cord-022594-fx044gcd	493	1	(	(	-LRB-
cord-022594-fx044gcd	494	1	r	r	LS
cord-022594-fx044gcd	494	2	¼	¼	NNP
cord-022594-fx044gcd	494	3	À0.64	À0.64	NNP
cord-022594-fx044gcd	494	4	,	,	,
cord-022594-fx044gcd	494	5	p	p	NN
cord-022594-fx044gcd	494	6	<	<	XX
cord-022594-fx044gcd	494	7	0.0001	0.0001	CD
cord-022594-fx044gcd	494	8	)	)	-RRB-
cord-022594-fx044gcd	494	9	than	than	IN
cord-022594-fx044gcd	494	10	in	in	IN
cord-022594-fx044gcd	494	11	the	the	DT
cord-022594-fx044gcd	494	12	RRMS	RRMS	NNP
cord-022594-fx044gcd	494	13	group	group	NN
cord-022594-fx044gcd	494	14	(	(	-LRB-
cord-022594-fx044gcd	494	15	r	r	NNP
cord-022594-fx044gcd	494	16	¼	¼	NNP
cord-022594-fx044gcd	494	17	À0.27	À0.27	NNP
cord-022594-fx044gcd	494	18	,	,	,
cord-022594-fx044gcd	494	19	p	p	NN
cord-022594-fx044gcd	494	20	¼	¼	CD
cord-022594-fx044gcd	494	21	0.04	0.04	CD
cord-022594-fx044gcd	494	22	)	)	-RRB-
cord-022594-fx044gcd	494	23	.	.	.
cord-022594-fx044gcd	495	1	50	50	CD
cord-022594-fx044gcd	495	2	MR	MR	NNP
cord-022594-fx044gcd	495	3	spectroscopy	spectroscopy	NN
cord-022594-fx044gcd	495	4	is	be	VBZ
cord-022594-fx044gcd	495	5	increasingly	increasingly	RB
cord-022594-fx044gcd	495	6	becoming	become	VBG
cord-022594-fx044gcd	495	7	an	an	DT
cord-022594-fx044gcd	495	8	accepted	accept	VBN
cord-022594-fx044gcd	495	9	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	495	10	modality	modality	NN
cord-022594-fx044gcd	495	11	,	,	,
cord-022594-fx044gcd	495	12	where	where	WRB
cord-022594-fx044gcd	495	13	information	information	NN
cord-022594-fx044gcd	495	14	can	can	MD
cord-022594-fx044gcd	495	15	be	be	VB
cord-022594-fx044gcd	495	16	obtained	obtain	VBN
cord-022594-fx044gcd	495	17	about	about	IN
cord-022594-fx044gcd	495	18	the	the	DT
cord-022594-fx044gcd	495	19	biochemical	biochemical	JJ
cord-022594-fx044gcd	495	20	constituents	constituent	NNS
cord-022594-fx044gcd	495	21	of	of	IN
cord-022594-fx044gcd	495	22	selected	select	VBN
cord-022594-fx044gcd	495	23	voxels	voxel	NNS
cord-022594-fx044gcd	495	24	of	of	IN
cord-022594-fx044gcd	495	25	interest	interest	NN
cord-022594-fx044gcd	495	26	.	.	.
cord-022594-fx044gcd	496	1	With	with	IN
cord-022594-fx044gcd	496	2	this	this	DT
cord-022594-fx044gcd	496	3	technique	technique	NN
cord-022594-fx044gcd	496	4	,	,	,
cord-022594-fx044gcd	496	5	a	a	DT
cord-022594-fx044gcd	496	6	cubic	cubic	JJ
cord-022594-fx044gcd	496	7	volume	volume	NN
cord-022594-fx044gcd	496	8	of	of	IN
cord-022594-fx044gcd	496	9	interest	interest	NN
cord-022594-fx044gcd	496	10	is	be	VBZ
cord-022594-fx044gcd	496	11	defined	define	VBN
cord-022594-fx044gcd	496	12	based	base	VBN
cord-022594-fx044gcd	496	13	on	on	IN
cord-022594-fx044gcd	496	14	a	a	DT
cord-022594-fx044gcd	496	15	regular	regular	JJ
cord-022594-fx044gcd	496	16	MR	MR	NNP
cord-022594-fx044gcd	496	17	image	image	NN
cord-022594-fx044gcd	496	18	set	set	NN
cord-022594-fx044gcd	496	19	.	.	.
cord-022594-fx044gcd	497	1	Simultaneous	simultaneous	JJ
cord-022594-fx044gcd	497	2	acquisition	acquisition	NN
cord-022594-fx044gcd	497	3	of	of	IN
cord-022594-fx044gcd	497	4	multiple	multiple	JJ
cord-022594-fx044gcd	497	5	volume	volume	NN
cord-022594-fx044gcd	497	6	units	unit	NNS
cord-022594-fx044gcd	497	7	is	be	VBZ
cord-022594-fx044gcd	497	8	possible	possible	JJ
cord-022594-fx044gcd	497	9	.	.	.
cord-022594-fx044gcd	498	1	With	with	IN
cord-022594-fx044gcd	498	2	long	long	JJ
cord-022594-fx044gcd	498	3	echo	echo	NN
cord-022594-fx044gcd	498	4	time	time	NN
cord-022594-fx044gcd	498	5	(	(	-LRB-
cord-022594-fx044gcd	498	6	TE	TE	NNP
cord-022594-fx044gcd	498	7	)	)	-RRB-
cord-022594-fx044gcd	498	8	studies	study	NNS
cord-022594-fx044gcd	498	9	,	,	,
cord-022594-fx044gcd	498	10	NAA	NAA	NNP
cord-022594-fx044gcd	498	11	(	(	-LRB-
cord-022594-fx044gcd	498	12	N	N	NNP
cord-022594-fx044gcd	498	13	-	-	HYPH
cord-022594-fx044gcd	498	14	acetylaspartate	acetylaspartate	NNP
cord-022594-fx044gcd	498	15	)	)	-RRB-
cord-022594-fx044gcd	498	16	,	,	,
cord-022594-fx044gcd	498	17	choline	choline	NN
cord-022594-fx044gcd	498	18	,	,	,
cord-022594-fx044gcd	498	19	creatinine	creatinine	NN
cord-022594-fx044gcd	498	20	,	,	,
cord-022594-fx044gcd	498	21	and	and	CC
cord-022594-fx044gcd	498	22	lactate	lactate	NN
cord-022594-fx044gcd	498	23	peaks	peak	NNS
cord-022594-fx044gcd	498	24	can	can	MD
cord-022594-fx044gcd	498	25	be	be	VB
cord-022594-fx044gcd	498	26	identified	identify	VBN
cord-022594-fx044gcd	498	27	on	on	IN
cord-022594-fx044gcd	498	28	the	the	DT
cord-022594-fx044gcd	498	29	MR	MR	NNP
cord-022594-fx044gcd	498	30	spectrum	spectrum	NN
cord-022594-fx044gcd	498	31	.	.	.
cord-022594-fx044gcd	499	1	With	with	IN
cord-022594-fx044gcd	499	2	short	short	JJ
cord-022594-fx044gcd	499	3	TE	TE	NNP
cord-022594-fx044gcd	499	4	studies	study	NNS
cord-022594-fx044gcd	499	5	,	,	,
cord-022594-fx044gcd	499	6	myoinositol	myoinositol	NNP
cord-022594-fx044gcd	499	7	,	,	,
cord-022594-fx044gcd	499	8	lipids	lipid	NNS
cord-022594-fx044gcd	499	9	,	,	,
cord-022594-fx044gcd	499	10	and	and	CC
cord-022594-fx044gcd	499	11	some	some	DT
cord-022594-fx044gcd	499	12	neurotransmitters	neurotransmitter	NNS
cord-022594-fx044gcd	499	13	may	may	MD
cord-022594-fx044gcd	499	14	be	be	VB
cord-022594-fx044gcd	499	15	identified	identify	VBN
cord-022594-fx044gcd	499	16	.	.	.
cord-022594-fx044gcd	500	1	The	the	DT
cord-022594-fx044gcd	500	2	resolution	resolution	NN
cord-022594-fx044gcd	500	3	of	of	IN
cord-022594-fx044gcd	500	4	the	the	DT
cord-022594-fx044gcd	500	5	MR	MR	NNP
cord-022594-fx044gcd	500	6	spectrum	spectrum	NNP
cord-022594-fx044gcd	500	7	(	(	-LRB-
cord-022594-fx044gcd	500	8	the	the	DT
cord-022594-fx044gcd	500	9	"	"	``
cord-022594-fx044gcd	500	10	number	number	NN
cord-022594-fx044gcd	500	11	of	of	IN
cord-022594-fx044gcd	500	12	lines	line	NNS
cord-022594-fx044gcd	500	13	"	"	''
cord-022594-fx044gcd	500	14	in	in	IN
cord-022594-fx044gcd	500	15	the	the	DT
cord-022594-fx044gcd	500	16	spectrum	spectrum	NN
cord-022594-fx044gcd	500	17	)	)	-RRB-
cord-022594-fx044gcd	500	18	is	be	VBZ
cord-022594-fx044gcd	500	19	proportionate	proportionate	JJ
cord-022594-fx044gcd	500	20	to	to	IN
cord-022594-fx044gcd	500	21	the	the	DT
cord-022594-fx044gcd	500	22	magnetic	magnetic	JJ
cord-022594-fx044gcd	500	23	field	field	NN
cord-022594-fx044gcd	500	24	strength	strength	NN
cord-022594-fx044gcd	500	25	used	use	VBN
cord-022594-fx044gcd	500	26	.	.	.
cord-022594-fx044gcd	501	1	NAA	NAA	NNP
cord-022594-fx044gcd	501	2	is	be	VBZ
cord-022594-fx044gcd	501	3	the	the	DT
cord-022594-fx044gcd	501	4	second	second	JJ
cord-022594-fx044gcd	501	5	most	most	RBS
cord-022594-fx044gcd	501	6	abundant	abundant	JJ
cord-022594-fx044gcd	501	7	amino	amino	NN
cord-022594-fx044gcd	501	8	acid	acid	NN
cord-022594-fx044gcd	501	9	constituent	constituent	NN
cord-022594-fx044gcd	501	10	in	in	IN
cord-022594-fx044gcd	501	11	the	the	DT
cord-022594-fx044gcd	501	12	brain	brain	NN
cord-022594-fx044gcd	501	13	after	after	IN
cord-022594-fx044gcd	501	14	glutamate	glutamate	NN
cord-022594-fx044gcd	501	15	.	.	.
cord-022594-fx044gcd	502	1	It	-PRON-	PRP
cord-022594-fx044gcd	502	2	is	be	VBZ
cord-022594-fx044gcd	502	3	localized	localize	VBN
cord-022594-fx044gcd	502	4	almost	almost	RB
cord-022594-fx044gcd	502	5	exclusively	exclusively	RB
cord-022594-fx044gcd	502	6	in	in	IN
cord-022594-fx044gcd	502	7	neurons	neuron	NNS
cord-022594-fx044gcd	502	8	and	and	CC
cord-022594-fx044gcd	502	9	axons	axon	NNS
cord-022594-fx044gcd	502	10	.	.	.
cord-022594-fx044gcd	503	1	Creatinine	creatinine	NN
cord-022594-fx044gcd	503	2	is	be	VBZ
cord-022594-fx044gcd	503	3	used	use	VBN
cord-022594-fx044gcd	503	4	as	as	IN
cord-022594-fx044gcd	503	5	the	the	DT
cord-022594-fx044gcd	503	6	"	"	``
cord-022594-fx044gcd	503	7	constant	constant	JJ
cord-022594-fx044gcd	503	8	"	"	''
cord-022594-fx044gcd	503	9	peak	peak	NN
cord-022594-fx044gcd	503	10	in	in	IN
cord-022594-fx044gcd	503	11	a	a	DT
cord-022594-fx044gcd	503	12	MR	MR	NNP
cord-022594-fx044gcd	503	13	spectrum	spectrum	NN
cord-022594-fx044gcd	503	14	,	,	,
cord-022594-fx044gcd	503	15	since	since	IN
cord-022594-fx044gcd	503	16	it	-PRON-	PRP
cord-022594-fx044gcd	503	17	is	be	VBZ
cord-022594-fx044gcd	503	18	the	the	DT
cord-022594-fx044gcd	503	19	least	least	RBS
cord-022594-fx044gcd	503	20	likely	likely	JJ
cord-022594-fx044gcd	503	21	to	to	TO
cord-022594-fx044gcd	503	22	be	be	VB
cord-022594-fx044gcd	503	23	altered	alter	VBN
cord-022594-fx044gcd	503	24	by	by	IN
cord-022594-fx044gcd	503	25	CNS	CNS	NNP
cord-022594-fx044gcd	503	26	-	-	HYPH
cord-022594-fx044gcd	503	27	specific	specific	JJ
cord-022594-fx044gcd	503	28	processes	process	NNS
cord-022594-fx044gcd	503	29	.	.	.
cord-022594-fx044gcd	504	1	Therefore	therefore	RB
cord-022594-fx044gcd	504	2	,	,	,
cord-022594-fx044gcd	504	3	numeric	numeric	JJ
cord-022594-fx044gcd	504	4	MRS	MRS	NNP
cord-022594-fx044gcd	504	5	data	datum	NNS
cord-022594-fx044gcd	504	6	are	be	VBP
cord-022594-fx044gcd	504	7	usually	usually	RB
cord-022594-fx044gcd	504	8	presented	present	VBN
cord-022594-fx044gcd	504	9	as	as	IN
cord-022594-fx044gcd	504	10	ratios	ratio	NNS
cord-022594-fx044gcd	504	11	related	relate	VBN
cord-022594-fx044gcd	504	12	to	to	IN
cord-022594-fx044gcd	504	13	creatinine	creatinine	NN
cord-022594-fx044gcd	504	14	.	.	.
cord-022594-fx044gcd	505	1	The	the	DT
cord-022594-fx044gcd	505	2	NAA	NAA	NNP
cord-022594-fx044gcd	505	3	/	/	SYM
cord-022594-fx044gcd	505	4	creatinine	creatinine	NN
cord-022594-fx044gcd	505	5	ratio	ratio	NN
cord-022594-fx044gcd	505	6	is	be	VBZ
cord-022594-fx044gcd	505	7	decreased	decrease	VBN
cord-022594-fx044gcd	505	8	in	in	IN
cord-022594-fx044gcd	505	9	areas	area	NNS
cord-022594-fx044gcd	505	10	of	of	IN
cord-022594-fx044gcd	505	11	axonal	axonal	JJ
cord-022594-fx044gcd	505	12	or	or	CC
cord-022594-fx044gcd	505	13	neuronal	neuronal	JJ
cord-022594-fx044gcd	505	14	loss	loss	NN
cord-022594-fx044gcd	505	15	.	.	.
cord-022594-fx044gcd	506	1	It	-PRON-	PRP
cord-022594-fx044gcd	506	2	correlates	correlate	VBZ
cord-022594-fx044gcd	506	3	well	well	RB
cord-022594-fx044gcd	506	4	with	with	IN
cord-022594-fx044gcd	506	5	disability	disability	NN
cord-022594-fx044gcd	506	6	.	.	.
cord-022594-fx044gcd	507	1	It	-PRON-	PRP
cord-022594-fx044gcd	507	2	can	can	MD
cord-022594-fx044gcd	507	3	be	be	VB
cord-022594-fx044gcd	507	4	decreased	decrease	VBN
cord-022594-fx044gcd	507	5	in	in	IN
cord-022594-fx044gcd	507	6	normal	normal	JJ
cord-022594-fx044gcd	507	7	appearing	appear	VBG
cord-022594-fx044gcd	507	8	white	white	JJ
cord-022594-fx044gcd	507	9	matter	matter	NN
cord-022594-fx044gcd	507	10	,	,	,
cord-022594-fx044gcd	507	11	also	also	RB
cord-022594-fx044gcd	507	12	in	in	IN
cord-022594-fx044gcd	507	13	early	early	JJ
cord-022594-fx044gcd	507	14	stages	stage	NNS
cord-022594-fx044gcd	507	15	of	of	IN
cord-022594-fx044gcd	507	16	lesion	lesion	NN
cord-022594-fx044gcd	507	17	formation	formation	NN
cord-022594-fx044gcd	507	18	,	,	,
cord-022594-fx044gcd	507	19	thus	thus	RB
cord-022594-fx044gcd	507	20	representing	represent	VBG
cord-022594-fx044gcd	507	21	a	a	DT
cord-022594-fx044gcd	507	22	challenge	challenge	NN
cord-022594-fx044gcd	507	23	to	to	IN
cord-022594-fx044gcd	507	24	the	the	DT
cord-022594-fx044gcd	507	25	usual	usual	JJ
cord-022594-fx044gcd	507	26	dogma	dogma	NN
cord-022594-fx044gcd	507	27	of	of	IN
cord-022594-fx044gcd	507	28	axonal	axonal	JJ
cord-022594-fx044gcd	507	29	loss	loss	NN
cord-022594-fx044gcd	507	30	being	be	VBG
cord-022594-fx044gcd	507	31	secondary	secondary	JJ
cord-022594-fx044gcd	507	32	to	to	IN
cord-022594-fx044gcd	507	33	myelin	myelin	JJ
cord-022594-fx044gcd	507	34	damage	damage	NN
cord-022594-fx044gcd	507	35	.	.	.
cord-022594-fx044gcd	508	1	The	the	DT
cord-022594-fx044gcd	508	2	decrease	decrease	NN
cord-022594-fx044gcd	508	3	of	of	IN
cord-022594-fx044gcd	508	4	the	the	DT
cord-022594-fx044gcd	508	5	NAA	NAA	NNP
cord-022594-fx044gcd	508	6	/	/	SYM
cord-022594-fx044gcd	508	7	creatinine	creatinine	NN
cord-022594-fx044gcd	508	8	ratio	ratio	NN
cord-022594-fx044gcd	508	9	may	may	MD
cord-022594-fx044gcd	508	10	return	return	VB
cord-022594-fx044gcd	508	11	to	to	IN
cord-022594-fx044gcd	508	12	normal	normal	JJ
cord-022594-fx044gcd	508	13	following	follow	VBG
cord-022594-fx044gcd	508	14	the	the	DT
cord-022594-fx044gcd	508	15	resolution	resolution	NN
cord-022594-fx044gcd	508	16	of	of	IN
cord-022594-fx044gcd	508	17	the	the	DT
cord-022594-fx044gcd	508	18	acute	acute	JJ
cord-022594-fx044gcd	508	19	phase	phase	NN
cord-022594-fx044gcd	508	20	.	.	.
cord-022594-fx044gcd	509	1	This	this	DT
cord-022594-fx044gcd	509	2	process	process	NN
cord-022594-fx044gcd	509	3	may	may	MD
cord-022594-fx044gcd	509	4	be	be	VB
cord-022594-fx044gcd	509	5	related	relate	VBN
cord-022594-fx044gcd	509	6	either	either	CC
cord-022594-fx044gcd	509	7	to	to	IN
cord-022594-fx044gcd	509	8	reversibility	reversibility	NN
cord-022594-fx044gcd	509	9	of	of	IN
cord-022594-fx044gcd	509	10	neuronal	neuronal	JJ
cord-022594-fx044gcd	509	11	injury	injury	NN
cord-022594-fx044gcd	509	12	or	or	CC
cord-022594-fx044gcd	509	13	to	to	IN
cord-022594-fx044gcd	509	14	disappearance	disappearance	NN
cord-022594-fx044gcd	509	15	of	of	IN
cord-022594-fx044gcd	509	16	edema	edema	NN
cord-022594-fx044gcd	509	17	in	in	IN
cord-022594-fx044gcd	509	18	the	the	DT
cord-022594-fx044gcd	509	19	involved	involved	JJ
cord-022594-fx044gcd	509	20	areas	area	NNS
cord-022594-fx044gcd	509	21	.	.	.
cord-022594-fx044gcd	510	1	In	in	IN
cord-022594-fx044gcd	510	2	general	general	JJ
cord-022594-fx044gcd	510	3	,	,	,
cord-022594-fx044gcd	510	4	more	more	RBR
cord-022594-fx044gcd	510	5	reduced	reduce	VBN
cord-022594-fx044gcd	510	6	NAA	NAA	NNP
cord-022594-fx044gcd	510	7	peaks	peak	NNS
cord-022594-fx044gcd	510	8	are	be	VBP
cord-022594-fx044gcd	510	9	seen	see	VBN
cord-022594-fx044gcd	510	10	in	in	IN
cord-022594-fx044gcd	510	11	progressive	progressive	JJ
cord-022594-fx044gcd	510	12	forms	form	NNS
cord-022594-fx044gcd	510	13	of	of	IN
cord-022594-fx044gcd	510	14	MS	MS	NNP
cord-022594-fx044gcd	510	15	with	with	IN
cord-022594-fx044gcd	510	16	more	more	RBR
cord-022594-fx044gcd	510	17	profound	profound	JJ
cord-022594-fx044gcd	510	18	tissue	tissue	NN
cord-022594-fx044gcd	510	19	loss	loss	NN
cord-022594-fx044gcd	510	20	.	.	.
cord-022594-fx044gcd	511	1	If	if	IN
cord-022594-fx044gcd	511	2	a	a	DT
cord-022594-fx044gcd	511	3	relatively	relatively	RB
cord-022594-fx044gcd	511	4	large	large	JJ
cord-022594-fx044gcd	511	5	hemispheric	hemispheric	JJ
cord-022594-fx044gcd	511	6	lesion	lesion	NN
cord-022594-fx044gcd	511	7	shows	show	NNS
cord-022594-fx044gcd	511	8	decreased	decrease	VBD
cord-022594-fx044gcd	511	9	NAA	NAA	NNP
cord-022594-fx044gcd	511	10	content	content	NN
cord-022594-fx044gcd	511	11	,	,	,
cord-022594-fx044gcd	511	12	similar	similar	JJ
cord-022594-fx044gcd	511	13	findings	finding	NNS
cord-022594-fx044gcd	511	14	may	may	MD
cord-022594-fx044gcd	511	15	be	be	VB
cord-022594-fx044gcd	511	16	seen	see	VBN
cord-022594-fx044gcd	511	17	in	in	IN
cord-022594-fx044gcd	511	18	the	the	DT
cord-022594-fx044gcd	511	19	other	other	JJ
cord-022594-fx044gcd	511	20	hemisphere	hemisphere	NN
cord-022594-fx044gcd	511	21	in	in	IN
cord-022594-fx044gcd	511	22	a	a	DT
cord-022594-fx044gcd	511	23	"	"	``
cord-022594-fx044gcd	511	24	mirror	mirror	NN
cord-022594-fx044gcd	511	25	"	"	''
cord-022594-fx044gcd	511	26	location	location	NN
cord-022594-fx044gcd	511	27	.	.	.
cord-022594-fx044gcd	512	1	The	the	DT
cord-022594-fx044gcd	512	2	lactate	lactate	NN
cord-022594-fx044gcd	512	3	peak	peak	NN
cord-022594-fx044gcd	512	4	can	can	MD
cord-022594-fx044gcd	512	5	be	be	VB
cord-022594-fx044gcd	512	6	elevated	elevate	VBN
cord-022594-fx044gcd	512	7	in	in	IN
cord-022594-fx044gcd	512	8	a	a	DT
cord-022594-fx044gcd	512	9	variety	variety	NN
cord-022594-fx044gcd	512	10	of	of	IN
cord-022594-fx044gcd	512	11	acute	acute	JJ
cord-022594-fx044gcd	512	12	processes	process	NNS
cord-022594-fx044gcd	512	13	,	,	,
cord-022594-fx044gcd	512	14	and	and	CC
cord-022594-fx044gcd	512	15	as	as	RB
cord-022594-fx044gcd	512	16	such	such	JJ
cord-022594-fx044gcd	512	17	,	,	,
cord-022594-fx044gcd	512	18	carries	carry	VBZ
cord-022594-fx044gcd	512	19	relatively	relatively	RB
cord-022594-fx044gcd	512	20	low	low	JJ
cord-022594-fx044gcd	512	21	specificity	specificity	NN
cord-022594-fx044gcd	512	22	.	.	.
cord-022594-fx044gcd	513	1	The	the	DT
cord-022594-fx044gcd	513	2	short	short	JJ
cord-022594-fx044gcd	513	3	TE	TE	NNP
cord-022594-fx044gcd	513	4	spectrum	spectrum	NN
cord-022594-fx044gcd	513	5	is	be	VBZ
cord-022594-fx044gcd	513	6	used	use	VBN
cord-022594-fx044gcd	513	7	less	less	RBR
cord-022594-fx044gcd	513	8	frequently	frequently	RB
cord-022594-fx044gcd	513	9	;	;	:
cord-022594-fx044gcd	513	10	the	the	DT
cord-022594-fx044gcd	513	11	"	"	``
cord-022594-fx044gcd	513	12	mobile	mobile	JJ
cord-022594-fx044gcd	513	13	lipid	lipid	NN
cord-022594-fx044gcd	513	14	"	"	''
cord-022594-fx044gcd	513	15	peak	peak	NN
cord-022594-fx044gcd	513	16	(	(	-LRB-
cord-022594-fx044gcd	513	17	which	which	WDT
cord-022594-fx044gcd	513	18	is	be	VBZ
cord-022594-fx044gcd	513	19	thought	think	VBN
cord-022594-fx044gcd	513	20	to	to	TO
cord-022594-fx044gcd	513	21	represent	represent	VB
cord-022594-fx044gcd	513	22	macromolecular	macromolecular	JJ
cord-022594-fx044gcd	513	23	protein	protein	NN
cord-022594-fx044gcd	513	24	fragments	fragment	NNS
cord-022594-fx044gcd	513	25	)	)	-RRB-
cord-022594-fx044gcd	513	26	is	be	VBZ
cord-022594-fx044gcd	513	27	increased	increase	VBN
cord-022594-fx044gcd	513	28	in	in	IN
cord-022594-fx044gcd	513	29	areas	area	NNS
cord-022594-fx044gcd	513	30	of	of	IN
cord-022594-fx044gcd	513	31	acute	acute	JJ
cord-022594-fx044gcd	513	32	demyelination	demyelination	NN
cord-022594-fx044gcd	513	33	.	.	.
cord-022594-fx044gcd	514	1	Another	another	DT
cord-022594-fx044gcd	514	2	newer	new	JJR
cord-022594-fx044gcd	514	3	MRI	MRI	NNP
cord-022594-fx044gcd	514	4	technique	technique	NN
cord-022594-fx044gcd	514	5	used	use	VBN
cord-022594-fx044gcd	514	6	in	in	IN
cord-022594-fx044gcd	514	7	MS	MS	NNP
cord-022594-fx044gcd	514	8	research	research	NN
cord-022594-fx044gcd	514	9	is	be	VBZ
cord-022594-fx044gcd	514	10	magnetization	magnetization	NN
cord-022594-fx044gcd	514	11	transfer	transfer	NN
cord-022594-fx044gcd	514	12	imaging	imaging	NN
cord-022594-fx044gcd	514	13	.	.	.
cord-022594-fx044gcd	515	1	The	the	DT
cord-022594-fx044gcd	515	2	principle	principle	NN
cord-022594-fx044gcd	515	3	behind	behind	IN
cord-022594-fx044gcd	515	4	this	this	DT
cord-022594-fx044gcd	515	5	imaging	imaging	NN
cord-022594-fx044gcd	515	6	modality	modality	NN
cord-022594-fx044gcd	515	7	is	be	VBZ
cord-022594-fx044gcd	515	8	relatively	relatively	RB
cord-022594-fx044gcd	515	9	simple	simple	JJ
cord-022594-fx044gcd	515	10	.	.	.
cord-022594-fx044gcd	516	1	In	in	IN
cord-022594-fx044gcd	516	2	complex	complex	JJ
cord-022594-fx044gcd	516	3	macromolecular	macromolecular	JJ
cord-022594-fx044gcd	516	4	systems	system	NNS
cord-022594-fx044gcd	516	5	,	,	,
cord-022594-fx044gcd	516	6	there	there	EX
cord-022594-fx044gcd	516	7	is	be	VBZ
cord-022594-fx044gcd	516	8	a	a	DT
cord-022594-fx044gcd	516	9	baseline	baseline	JJ
cord-022594-fx044gcd	516	10	magnetization	magnetization	NN
cord-022594-fx044gcd	516	11	exchange	exchange	NN
cord-022594-fx044gcd	516	12	in	in	IN
cord-022594-fx044gcd	516	13	equilibrium	equilibrium	NN
cord-022594-fx044gcd	516	14	between	between	IN
cord-022594-fx044gcd	516	15	macromolecular	macromolecular	JJ
cord-022594-fx044gcd	516	16	protons	proton	NNS
cord-022594-fx044gcd	516	17	and	and	CC
cord-022594-fx044gcd	516	18	mobile	mobile	NN
cord-022594-fx044gcd	516	19	protons	proton	NNS
cord-022594-fx044gcd	516	20	.	.	.
cord-022594-fx044gcd	517	1	If	if	IN
cord-022594-fx044gcd	517	2	the	the	DT
cord-022594-fx044gcd	517	3	macromolecular	macromolecular	JJ
cord-022594-fx044gcd	517	4	protons	proton	NNS
cord-022594-fx044gcd	517	5	are	be	VBP
cord-022594-fx044gcd	517	6	saturated	saturate	VBN
cord-022594-fx044gcd	517	7	before	before	IN
cord-022594-fx044gcd	517	8	each	each	DT
cord-022594-fx044gcd	517	9	excitation	excitation	NN
cord-022594-fx044gcd	517	10	(	(	-LRB-
cord-022594-fx044gcd	517	11	and	and	CC
cord-022594-fx044gcd	517	12	subsequent	subsequent	JJ
cord-022594-fx044gcd	517	13	data	data	NN
cord-022594-fx044gcd	517	14	acquisition	acquisition	NN
cord-022594-fx044gcd	517	15	)	)	-RRB-
cord-022594-fx044gcd	517	16	with	with	IN
cord-022594-fx044gcd	517	17	a	a	DT
cord-022594-fx044gcd	517	18	prolonged	prolong	VBN
cord-022594-fx044gcd	517	19	off	off	IN
cord-022594-fx044gcd	517	20	-	-	HYPH
cord-022594-fx044gcd	517	21	resonance	resonance	NN
cord-022594-fx044gcd	517	22	broadband	broadband	NN
cord-022594-fx044gcd	517	23	pulse	pulse	NN
cord-022594-fx044gcd	517	24	,	,	,
cord-022594-fx044gcd	517	25	then	then	RB
cord-022594-fx044gcd	517	26	the	the	DT
cord-022594-fx044gcd	517	27	signal	signal	JJ
cord-022594-fx044gcd	517	28	intensity	intensity	NN
cord-022594-fx044gcd	517	29	of	of	IN
cord-022594-fx044gcd	517	30	the	the	DT
cord-022594-fx044gcd	517	31	image	image	NN
cord-022594-fx044gcd	517	32	will	will	MD
cord-022594-fx044gcd	517	33	be	be	VB
cord-022594-fx044gcd	517	34	reduced	reduce	VBN
cord-022594-fx044gcd	517	35	owing	owe	VBG
cord-022594-fx044gcd	517	36	to	to	IN
cord-022594-fx044gcd	517	37	magnetization	magnetization	NN
cord-022594-fx044gcd	517	38	transfer	transfer	NN
cord-022594-fx044gcd	517	39	exchange	exchange	NN
cord-022594-fx044gcd	517	40	between	between	IN
cord-022594-fx044gcd	517	41	the	the	DT
cord-022594-fx044gcd	517	42	saturated	saturated	JJ
cord-022594-fx044gcd	517	43	(	(	-LRB-
cord-022594-fx044gcd	517	44	"	"	``
cord-022594-fx044gcd	517	45	bound	bind	VBN
cord-022594-fx044gcd	517	46	"	"	''
cord-022594-fx044gcd	517	47	)	)	-RRB-
cord-022594-fx044gcd	517	48	and	and	CC
cord-022594-fx044gcd	517	49	free	free	JJ
cord-022594-fx044gcd	517	50	(	(	-LRB-
cord-022594-fx044gcd	517	51	"	"	``
cord-022594-fx044gcd	517	52	mobile	mobile	JJ
cord-022594-fx044gcd	517	53	"	"	''
cord-022594-fx044gcd	517	54	)	)	-RRB-
cord-022594-fx044gcd	517	55	protons	proton	NNS
cord-022594-fx044gcd	517	56	.	.	.
cord-022594-fx044gcd	518	1	By	by	IN
cord-022594-fx044gcd	518	2	obtaining	obtain	VBG
cord-022594-fx044gcd	518	3	duplicate	duplicate	JJ
cord-022594-fx044gcd	518	4	sets	set	NNS
cord-022594-fx044gcd	518	5	of	of	IN
cord-022594-fx044gcd	518	6	images	image	NNS
cord-022594-fx044gcd	518	7	(	(	-LRB-
cord-022594-fx044gcd	518	8	with	with	IN
cord-022594-fx044gcd	518	9	and	and	CC
cord-022594-fx044gcd	518	10	without	without	IN
cord-022594-fx044gcd	518	11	magnetization	magnetization	NN
cord-022594-fx044gcd	518	12	transfer	transfer	NN
cord-022594-fx044gcd	518	13	pulse	pulse	NN
cord-022594-fx044gcd	518	14	)	)	-RRB-
cord-022594-fx044gcd	518	15	,	,	,
cord-022594-fx044gcd	518	16	a	a	DT
cord-022594-fx044gcd	518	17	magnetization	magnetization	NN
cord-022594-fx044gcd	518	18	transfer	transfer	NN
cord-022594-fx044gcd	518	19	ratio	ratio	NN
cord-022594-fx044gcd	518	20	can	can	MD
cord-022594-fx044gcd	518	21	be	be	VB
cord-022594-fx044gcd	518	22	calculated	calculate	VBN
cord-022594-fx044gcd	518	23	.	.	.
cord-022594-fx044gcd	519	1	The	the	DT
cord-022594-fx044gcd	519	2	ratio	ratio	NN
cord-022594-fx044gcd	519	3	reflects	reflect	VBZ
cord-022594-fx044gcd	519	4	the	the	DT
cord-022594-fx044gcd	519	5	integrity	integrity	NN
cord-022594-fx044gcd	519	6	of	of	IN
cord-022594-fx044gcd	519	7	the	the	DT
cord-022594-fx044gcd	519	8	macromolecular	macromolecular	JJ
cord-022594-fx044gcd	519	9	environment	environment	NN
cord-022594-fx044gcd	519	10	.	.	.
cord-022594-fx044gcd	520	1	It	-PRON-	PRP
cord-022594-fx044gcd	520	2	is	be	VBZ
cord-022594-fx044gcd	520	3	reduced	reduce	VBN
cord-022594-fx044gcd	520	4	by	by	IN
cord-022594-fx044gcd	520	5	approximately	approximately	RB
cord-022594-fx044gcd	520	6	3	3	CD
cord-022594-fx044gcd	520	7	%	%	NN
cord-022594-fx044gcd	520	8	to	to	TO
cord-022594-fx044gcd	520	9	5	5	CD
cord-022594-fx044gcd	520	10	%	%	NN
cord-022594-fx044gcd	520	11	in	in	IN
cord-022594-fx044gcd	520	12	areas	area	NNS
cord-022594-fx044gcd	520	13	of	of	IN
cord-022594-fx044gcd	520	14	edema	edema	NN
cord-022594-fx044gcd	520	15	,	,	,
cord-022594-fx044gcd	520	16	but	but	CC
cord-022594-fx044gcd	520	17	it	-PRON-	PRP
cord-022594-fx044gcd	520	18	is	be	VBZ
cord-022594-fx044gcd	520	19	more	more	RBR
cord-022594-fx044gcd	520	20	significantly	significantly	RB
cord-022594-fx044gcd	520	21	reduced	reduce	VBN
cord-022594-fx044gcd	520	22	in	in	IN
cord-022594-fx044gcd	520	23	areas	area	NNS
cord-022594-fx044gcd	520	24	of	of	IN
cord-022594-fx044gcd	520	25	demyelination	demyelination	NN
cord-022594-fx044gcd	520	26	or	or	CC
cord-022594-fx044gcd	520	27	axonal	axonal	JJ
cord-022594-fx044gcd	520	28	loss	loss	NN
cord-022594-fx044gcd	520	29	.	.	.
cord-022594-fx044gcd	521	1	If	if	IN
cord-022594-fx044gcd	521	2	the	the	DT
cord-022594-fx044gcd	521	3	ratio	ratio	NN
cord-022594-fx044gcd	521	4	"	"	``
cord-022594-fx044gcd	521	5	normalizes	normalize	VBZ
cord-022594-fx044gcd	521	6	"	"	''
cord-022594-fx044gcd	521	7	in	in	IN
cord-022594-fx044gcd	521	8	a	a	DT
cord-022594-fx044gcd	521	9	lesion	lesion	NN
cord-022594-fx044gcd	521	10	,	,	,
cord-022594-fx044gcd	521	11	no	no	DT
cord-022594-fx044gcd	521	12	subsequent	subsequent	JJ
cord-022594-fx044gcd	521	13	tissue	tissue	NN
cord-022594-fx044gcd	521	14	loss	loss	NN
cord-022594-fx044gcd	521	15	is	be	VBZ
cord-022594-fx044gcd	521	16	usually	usually	RB
cord-022594-fx044gcd	521	17	seen	see	VBN
cord-022594-fx044gcd	521	18	on	on	IN
cord-022594-fx044gcd	521	19	other	other	JJ
cord-022594-fx044gcd	521	20	imaging	imaging	NN
cord-022594-fx044gcd	521	21	modalities	modality	NNS
cord-022594-fx044gcd	521	22	.	.	.
cord-022594-fx044gcd	522	1	Despite	despite	IN
cord-022594-fx044gcd	522	2	these	these	DT
cord-022594-fx044gcd	522	3	advantages	advantage	NNS
cord-022594-fx044gcd	522	4	,	,	,
cord-022594-fx044gcd	522	5	the	the	DT
cord-022594-fx044gcd	522	6	magnetization	magnetization	NN
cord-022594-fx044gcd	522	7	transfer	transfer	NN
cord-022594-fx044gcd	522	8	imaging	imaging	NN
cord-022594-fx044gcd	522	9	is	be	VBZ
cord-022594-fx044gcd	522	10	technically	technically	RB
cord-022594-fx044gcd	522	11	difficult	difficult	JJ
cord-022594-fx044gcd	522	12	because	because	IN
cord-022594-fx044gcd	522	13	it	-PRON-	PRP
cord-022594-fx044gcd	522	14	produces	produce	VBZ
cord-022594-fx044gcd	522	15	variable	variable	JJ
cord-022594-fx044gcd	522	16	findings	finding	NNS
cord-022594-fx044gcd	522	17	depending	depend	VBG
cord-022594-fx044gcd	522	18	on	on	IN
cord-022594-fx044gcd	522	19	the	the	DT
cord-022594-fx044gcd	522	20	technical	technical	JJ
cord-022594-fx044gcd	522	21	environment	environment	NN
cord-022594-fx044gcd	522	22	and	and	CC
cord-022594-fx044gcd	522	23	is	be	VBZ
cord-022594-fx044gcd	522	24	not	not	RB
cord-022594-fx044gcd	522	25	universally	universally	RB
cord-022594-fx044gcd	522	26	available	available	JJ
cord-022594-fx044gcd	522	27	.	.	.
cord-022594-fx044gcd	523	1	It	-PRON-	PRP
cord-022594-fx044gcd	523	2	has	have	VBZ
cord-022594-fx044gcd	523	3	not	not	RB
cord-022594-fx044gcd	523	4	become	become	VBN
cord-022594-fx044gcd	523	5	an	an	DT
cord-022594-fx044gcd	523	6	accepted	accepted	JJ
cord-022594-fx044gcd	523	7	and	and	CC
cord-022594-fx044gcd	523	8	standard	standard	JJ
cord-022594-fx044gcd	523	9	technique	technique	NN
cord-022594-fx044gcd	523	10	for	for	IN
cord-022594-fx044gcd	523	11	evaluation	evaluation	NN
cord-022594-fx044gcd	523	12	of	of	IN
cord-022594-fx044gcd	523	13	MS	MS	NNP
cord-022594-fx044gcd	523	14	patients	patient	NNS
cord-022594-fx044gcd	523	15	.	.	.
cord-022594-fx044gcd	524	1	It	-PRON-	PRP
cord-022594-fx044gcd	524	2	may	may	MD
cord-022594-fx044gcd	524	3	be	be	VB
cord-022594-fx044gcd	524	4	very	very	RB
cord-022594-fx044gcd	524	5	useful	useful	JJ
cord-022594-fx044gcd	524	6	as	as	IN
cord-022594-fx044gcd	524	7	a	a	DT
cord-022594-fx044gcd	524	8	marker	marker	NN
cord-022594-fx044gcd	524	9	for	for	IN
cord-022594-fx044gcd	524	10	remyelination	remyelination	NN
cord-022594-fx044gcd	524	11	and	and	CC
cord-022594-fx044gcd	524	12	tissue	tissue	NN
cord-022594-fx044gcd	524	13	repair	repair	NN
cord-022594-fx044gcd	524	14	in	in	IN
cord-022594-fx044gcd	524	15	future	future	JJ
cord-022594-fx044gcd	524	16	neuroprotective	neuroprotective	JJ
cord-022594-fx044gcd	524	17	or	or	CC
cord-022594-fx044gcd	524	18	tissue	tissue	VB
cord-022594-fx044gcd	524	19	restorative	restorative	JJ
cord-022594-fx044gcd	524	20	trials	trial	NNS
cord-022594-fx044gcd	524	21	.	.	.
cord-022594-fx044gcd	525	1	Diffusion	diffusion	NN
cord-022594-fx044gcd	525	2	-	-	HYPH
cord-022594-fx044gcd	525	3	weighted	weight	VBN
cord-022594-fx044gcd	525	4	imaging	imaging	NN
cord-022594-fx044gcd	525	5	is	be	VBZ
cord-022594-fx044gcd	525	6	well	well	RB
cord-022594-fx044gcd	525	7	known	know	VBN
cord-022594-fx044gcd	525	8	from	from	IN
cord-022594-fx044gcd	525	9	its	-PRON-	PRP$
cord-022594-fx044gcd	525	10	widespread	widespread	JJ
cord-022594-fx044gcd	525	11	use	use	NN
cord-022594-fx044gcd	525	12	in	in	IN
cord-022594-fx044gcd	525	13	the	the	DT
cord-022594-fx044gcd	525	14	diagnosis	diagnosis	NN
cord-022594-fx044gcd	525	15	of	of	IN
cord-022594-fx044gcd	525	16	ischemic	ischemic	JJ
cord-022594-fx044gcd	525	17	stroke	stroke	NN
cord-022594-fx044gcd	525	18	.	.	.
cord-022594-fx044gcd	526	1	This	this	DT
cord-022594-fx044gcd	526	2	technique	technique	NN
cord-022594-fx044gcd	526	3	can	can	MD
cord-022594-fx044gcd	526	4	show	show	VB
cord-022594-fx044gcd	526	5	early	early	JJ
cord-022594-fx044gcd	526	6	stages	stage	NNS
cord-022594-fx044gcd	526	7	of	of	IN
cord-022594-fx044gcd	526	8	MS	MS	NNP
cord-022594-fx044gcd	526	9	plaque	plaque	NN
cord-022594-fx044gcd	526	10	formation	formation	NN
cord-022594-fx044gcd	526	11	.	.	.
cord-022594-fx044gcd	527	1	The	the	DT
cord-022594-fx044gcd	527	2	increase	increase	NN
cord-022594-fx044gcd	527	3	in	in	IN
cord-022594-fx044gcd	527	4	apparent	apparent	JJ
cord-022594-fx044gcd	527	5	diffusion	diffusion	NN
cord-022594-fx044gcd	527	6	coefficient	coefficient	NN
cord-022594-fx044gcd	527	7	correlates	correlate	VBZ
cord-022594-fx044gcd	527	8	with	with	IN
cord-022594-fx044gcd	527	9	acute	acute	JJ
cord-022594-fx044gcd	527	10	plaques	plaque	NNS
cord-022594-fx044gcd	527	11	,	,	,
cord-022594-fx044gcd	527	12	and	and	CC
cord-022594-fx044gcd	527	13	seems	seem	VBZ
cord-022594-fx044gcd	527	14	to	to	TO
cord-022594-fx044gcd	527	15	best	good	JJS
cord-022594-fx044gcd	527	16	correspond	correspond	VB
cord-022594-fx044gcd	527	17	with	with	IN
cord-022594-fx044gcd	527	18	T1-enhancing	t1-enhance	VBG
cord-022594-fx044gcd	527	19	lesions	lesion	NNS
cord-022594-fx044gcd	527	20	;	;	:
cord-022594-fx044gcd	527	21	this	this	DT
cord-022594-fx044gcd	527	22	technique	technique	NN
cord-022594-fx044gcd	527	23	may	may	MD
cord-022594-fx044gcd	527	24	show	show	VB
cord-022594-fx044gcd	527	25	the	the	DT
cord-022594-fx044gcd	527	26	lesions	lesion	NNS
cord-022594-fx044gcd	527	27	at	at	IN
cord-022594-fx044gcd	527	28	an	an	DT
cord-022594-fx044gcd	527	29	even	even	RB
cord-022594-fx044gcd	527	30	earlier	early	JJR
cord-022594-fx044gcd	527	31	stage	stage	NN
cord-022594-fx044gcd	527	32	.	.	.
cord-022594-fx044gcd	528	1	MRI	MRI	NNP
cord-022594-fx044gcd	528	2	has	have	VBZ
cord-022594-fx044gcd	528	3	become	become	VBN
cord-022594-fx044gcd	528	4	an	an	DT
cord-022594-fx044gcd	528	5	important	important	JJ
cord-022594-fx044gcd	528	6	component	component	NN
cord-022594-fx044gcd	528	7	of	of	IN
cord-022594-fx044gcd	528	8	clinical	clinical	JJ
cord-022594-fx044gcd	528	9	trials	trial	NNS
cord-022594-fx044gcd	528	10	in	in	IN
cord-022594-fx044gcd	528	11	MS	MS	NNP
cord-022594-fx044gcd	528	12	.	.	.
cord-022594-fx044gcd	529	1	Because	because	IN
cord-022594-fx044gcd	529	2	of	of	IN
cord-022594-fx044gcd	529	3	the	the	DT
cord-022594-fx044gcd	529	4	high	high	JJ
cord-022594-fx044gcd	529	5	sensitivity	sensitivity	NN
cord-022594-fx044gcd	529	6	of	of	IN
cord-022594-fx044gcd	529	7	MRI	MRI	NNP
cord-022594-fx044gcd	529	8	for	for	IN
cord-022594-fx044gcd	529	9	disease	disease	NN
cord-022594-fx044gcd	529	10	activity	activity	NN
cord-022594-fx044gcd	529	11	,	,	,
cord-022594-fx044gcd	529	12	it	-PRON-	PRP
cord-022594-fx044gcd	529	13	is	be	VBZ
cord-022594-fx044gcd	529	14	reasoned	reason	VBN
cord-022594-fx044gcd	529	15	that	that	IN
cord-022594-fx044gcd	529	16	periodic	periodic	JJ
cord-022594-fx044gcd	529	17	MRI	MRI	NNP
cord-022594-fx044gcd	529	18	may	may	MD
cord-022594-fx044gcd	529	19	determine	determine	VB
cord-022594-fx044gcd	529	20	treatment	treatment	NN
cord-022594-fx044gcd	529	21	efficacy	efficacy	NN
cord-022594-fx044gcd	529	22	more	more	RBR
cord-022594-fx044gcd	529	23	quickly	quickly	RB
cord-022594-fx044gcd	529	24	than	than	IN
cord-022594-fx044gcd	529	25	monitoring	monitor	VBG
cord-022594-fx044gcd	529	26	relapse	relapse	NN
cord-022594-fx044gcd	529	27	rate	rate	NN
cord-022594-fx044gcd	529	28	or	or	CC
cord-022594-fx044gcd	529	29	disability	disability	NN
cord-022594-fx044gcd	529	30	level	level	NN
cord-022594-fx044gcd	529	31	.	.	.
cord-022594-fx044gcd	530	1	Many	many	JJ
cord-022594-fx044gcd	530	2	studies	study	NNS
cord-022594-fx044gcd	530	3	have	have	VBP
cord-022594-fx044gcd	530	4	used	use	VBN
cord-022594-fx044gcd	530	5	MRI	MRI	NNP
cord-022594-fx044gcd	530	6	as	as	IN
cord-022594-fx044gcd	530	7	a	a	DT
cord-022594-fx044gcd	530	8	secondary	secondary	JJ
cord-022594-fx044gcd	530	9	outcome	outcome	NN
cord-022594-fx044gcd	530	10	,	,	,
cord-022594-fx044gcd	530	11	but	but	CC
cord-022594-fx044gcd	530	12	clinical	clinical	JJ
cord-022594-fx044gcd	530	13	outcomes	outcome	NNS
cord-022594-fx044gcd	530	14	are	be	VBP
cord-022594-fx044gcd	530	15	still	still	RB
cord-022594-fx044gcd	530	16	used	use	VBN
cord-022594-fx044gcd	530	17	as	as	IN
cord-022594-fx044gcd	530	18	the	the	DT
cord-022594-fx044gcd	530	19	primary	primary	JJ
cord-022594-fx044gcd	530	20	outcome	outcome	NN
cord-022594-fx044gcd	530	21	for	for	IN
cord-022594-fx044gcd	530	22	definitive	definitive	JJ
cord-022594-fx044gcd	530	23	trials	trial	NNS
cord-022594-fx044gcd	530	24	.	.	.
cord-022594-fx044gcd	531	1	Additional	additional	JJ
cord-022594-fx044gcd	531	2	MRI	MRI	NNP
cord-022594-fx044gcd	531	3	techniques	technique	NNS
cord-022594-fx044gcd	531	4	have	have	VBP
cord-022594-fx044gcd	531	5	also	also	RB
cord-022594-fx044gcd	531	6	proved	prove	VBN
cord-022594-fx044gcd	531	7	useful	useful	JJ
cord-022594-fx044gcd	531	8	in	in	IN
cord-022594-fx044gcd	531	9	the	the	DT
cord-022594-fx044gcd	531	10	diagnosis	diagnosis	NN
cord-022594-fx044gcd	531	11	of	of	IN
cord-022594-fx044gcd	531	12	MS	MS	NNP
cord-022594-fx044gcd	531	13	.	.	.
cord-022594-fx044gcd	532	1	MRI	MRI	NNP
cord-022594-fx044gcd	532	2	of	of	IN
cord-022594-fx044gcd	532	3	the	the	DT
cord-022594-fx044gcd	532	4	spinal	spinal	JJ
cord-022594-fx044gcd	532	5	cord	cord	NN
cord-022594-fx044gcd	532	6	shows	show	VBZ
cord-022594-fx044gcd	532	7	discrete	discrete	JJ
cord-022594-fx044gcd	532	8	lesions	lesion	NNS
cord-022594-fx044gcd	532	9	in	in	IN
cord-022594-fx044gcd	532	10	about	about	RB
cord-022594-fx044gcd	532	11	80	80	CD
cord-022594-fx044gcd	532	12	%	%	NN
cord-022594-fx044gcd	532	13	of	of	IN
cord-022594-fx044gcd	532	14	CDMS	CDMS	NNP
cord-022594-fx044gcd	532	15	patients	patient	NNS
cord-022594-fx044gcd	532	16	.	.	.
cord-022594-fx044gcd	533	1	Several	several	JJ
cord-022594-fx044gcd	533	2	semiautomatic	semiautomatic	JJ
cord-022594-fx044gcd	533	3	methods	method	NNS
cord-022594-fx044gcd	533	4	exist	exist	VBP
cord-022594-fx044gcd	533	5	to	to	TO
cord-022594-fx044gcd	533	6	determine	determine	VB
cord-022594-fx044gcd	533	7	lesion	lesion	NN
cord-022594-fx044gcd	533	8	volume	volume	NN
cord-022594-fx044gcd	533	9	,	,	,
cord-022594-fx044gcd	533	10	ventricle	ventricle	NN
cord-022594-fx044gcd	533	11	volume	volume	NN
cord-022594-fx044gcd	533	12	,	,	,
cord-022594-fx044gcd	533	13	or	or	CC
cord-022594-fx044gcd	533	14	hemispheric	hemispheric	JJ
cord-022594-fx044gcd	533	15	volume	volume	NN
cord-022594-fx044gcd	533	16	.	.	.
cord-022594-fx044gcd	534	1	These	these	DT
cord-022594-fx044gcd	534	2	are	be	VBP
cord-022594-fx044gcd	534	3	generally	generally	RB
cord-022594-fx044gcd	534	4	applied	apply	VBN
cord-022594-fx044gcd	534	5	for	for	IN
cord-022594-fx044gcd	534	6	research	research	NN
cord-022594-fx044gcd	534	7	purposes	purpose	NNS
cord-022594-fx044gcd	534	8	only	only	RB
cord-022594-fx044gcd	534	9	,	,	,
cord-022594-fx044gcd	534	10	and	and	CC
cord-022594-fx044gcd	534	11	are	be	VBP
cord-022594-fx044gcd	534	12	not	not	RB
cord-022594-fx044gcd	534	13	part	part	NN
cord-022594-fx044gcd	534	14	of	of	IN
cord-022594-fx044gcd	534	15	the	the	DT
cord-022594-fx044gcd	534	16	usual	usual	JJ
cord-022594-fx044gcd	534	17	workup	workup	NN
cord-022594-fx044gcd	534	18	or	or	CC
cord-022594-fx044gcd	534	19	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	534	20	follow	follow	NN
cord-022594-fx044gcd	534	21	-	-	HYPH
cord-022594-fx044gcd	534	22	up	up	NN
cord-022594-fx044gcd	534	23	of	of	IN
cord-022594-fx044gcd	534	24	MS	MS	NNP
cord-022594-fx044gcd	534	25	.	.	.
cord-022594-fx044gcd	535	1	CSF	csf	NN
cord-022594-fx044gcd	535	2	evaluation	evaluation	NN
cord-022594-fx044gcd	535	3	remains	remain	VBZ
cord-022594-fx044gcd	535	4	a	a	DT
cord-022594-fx044gcd	535	5	valuable	valuable	JJ
cord-022594-fx044gcd	535	6	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	535	7	tool	tool	NN
cord-022594-fx044gcd	535	8	for	for	IN
cord-022594-fx044gcd	535	9	MS	MS	NNP
cord-022594-fx044gcd	535	10	.	.	.
cord-022594-fx044gcd	536	1	A	a	DT
cord-022594-fx044gcd	536	2	lymphocytic	lymphocytic	JJ
cord-022594-fx044gcd	536	3	pleocytosis	pleocytosis	NN
cord-022594-fx044gcd	536	4	occurs	occur	VBZ
cord-022594-fx044gcd	536	5	during	during	IN
cord-022594-fx044gcd	536	6	acute	acute	JJ
cord-022594-fx044gcd	536	7	exacerbations	exacerbation	NNS
cord-022594-fx044gcd	536	8	in	in	IN
cord-022594-fx044gcd	536	9	about	about	RB
cord-022594-fx044gcd	536	10	one	one	CD
cord-022594-fx044gcd	536	11	third	third	NN
cord-022594-fx044gcd	536	12	of	of	IN
cord-022594-fx044gcd	536	13	patients	patient	NNS
cord-022594-fx044gcd	536	14	,	,	,
cord-022594-fx044gcd	536	15	but	but	CC
cord-022594-fx044gcd	536	16	this	this	DT
cord-022594-fx044gcd	536	17	seldom	seldom	RB
cord-022594-fx044gcd	536	18	exceeds	exceed	VBZ
cord-022594-fx044gcd	536	19	50	50	CD
cord-022594-fx044gcd	536	20	cells	cell	NNS
cord-022594-fx044gcd	536	21	.	.	.
cord-022594-fx044gcd	537	1	Eighty	eighty	CD
cord-022594-fx044gcd	537	2	percent	percent	NN
cord-022594-fx044gcd	537	3	of	of	IN
cord-022594-fx044gcd	537	4	the	the	DT
cord-022594-fx044gcd	537	5	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	537	6	are	be	VBP
cord-022594-fx044gcd	537	7	CD3	CD3	NNP
cord-022594-fx044gcd	537	8	positive	positive	JJ
cord-022594-fx044gcd	537	9	.	.	.
cord-022594-fx044gcd	538	1	The	the	DT
cord-022594-fx044gcd	538	2	ratio	ratio	NN
cord-022594-fx044gcd	538	3	of	of	IN
cord-022594-fx044gcd	538	4	CD4	CD4	NNP
cord-022594-fx044gcd	538	5	to	to	IN
cord-022594-fx044gcd	538	6	CD8	CD8	NNP
cord-022594-fx044gcd	538	7	cells	cell	NNS
cord-022594-fx044gcd	538	8	is	be	VBZ
cord-022594-fx044gcd	538	9	2:1	2:1	CD
cord-022594-fx044gcd	538	10	.	.	.
cord-022594-fx044gcd	539	1	Less	Less	JJR
cord-022594-fx044gcd	539	2	than	than	IN
cord-022594-fx044gcd	539	3	20	20	CD
cord-022594-fx044gcd	539	4	%	%	NN
cord-022594-fx044gcd	539	5	of	of	IN
cord-022594-fx044gcd	539	6	the	the	DT
cord-022594-fx044gcd	539	7	cells	cell	NNS
cord-022594-fx044gcd	539	8	are	be	VBP
cord-022594-fx044gcd	539	9	B	b	NN
cord-022594-fx044gcd	539	10	cells	cell	NNS
cord-022594-fx044gcd	539	11	.	.	.
cord-022594-fx044gcd	540	1	CSF	CSF	NNP
cord-022594-fx044gcd	540	2	protein	protein	NN
cord-022594-fx044gcd	540	3	is	be	VBZ
cord-022594-fx044gcd	540	4	normal	normal	JJ
cord-022594-fx044gcd	540	5	in	in	IN
cord-022594-fx044gcd	540	6	up	up	IN
cord-022594-fx044gcd	540	7	to	to	TO
cord-022594-fx044gcd	540	8	60	60	CD
cord-022594-fx044gcd	540	9	%	%	NN
cord-022594-fx044gcd	540	10	;	;	,
cord-022594-fx044gcd	540	11	levels	level	NNS
cord-022594-fx044gcd	540	12	above	above	IN
cord-022594-fx044gcd	540	13	100	100	CD
cord-022594-fx044gcd	540	14	mg	mg	NNP
cord-022594-fx044gcd	540	15	/	/	SYM
cord-022594-fx044gcd	540	16	dL	dL	NNP
cord-022594-fx044gcd	540	17	are	be	VBP
cord-022594-fx044gcd	540	18	unusual	unusual	JJ
cord-022594-fx044gcd	540	19	and	and	CC
cord-022594-fx044gcd	540	20	may	may	MD
cord-022594-fx044gcd	540	21	suggest	suggest	VB
cord-022594-fx044gcd	540	22	a	a	DT
cord-022594-fx044gcd	540	23	different	different	JJ
cord-022594-fx044gcd	540	24	disorder	disorder	NN
cord-022594-fx044gcd	540	25	.	.	.
cord-022594-fx044gcd	541	1	The	the	DT
cord-022594-fx044gcd	541	2	proportion	proportion	NN
cord-022594-fx044gcd	541	3	of	of	IN
cord-022594-fx044gcd	541	4	g	g	NN
cord-022594-fx044gcd	541	5	globulin	globulin	NN
cord-022594-fx044gcd	541	6	is	be	VBZ
cord-022594-fx044gcd	541	7	high	high	JJ
cord-022594-fx044gcd	541	8	owing	owe	VBG
cord-022594-fx044gcd	541	9	to	to	IN
cord-022594-fx044gcd	541	10	the	the	DT
cord-022594-fx044gcd	541	11	synthesis	synthesis	NN
cord-022594-fx044gcd	541	12	of	of	IN
cord-022594-fx044gcd	541	13	immunoglobulins	immunoglobulin	NNS
cord-022594-fx044gcd	541	14	within	within	IN
cord-022594-fx044gcd	541	15	the	the	DT
cord-022594-fx044gcd	541	16	blood	blood	NN
cord-022594-fx044gcd	541	17	-	-	HYPH
cord-022594-fx044gcd	541	18	brain	brain	NN
cord-022594-fx044gcd	541	19	barrier	barrier	NN
cord-022594-fx044gcd	541	20	.	.	.
cord-022594-fx044gcd	542	1	The	the	DT
cord-022594-fx044gcd	542	2	majority	majority	NN
cord-022594-fx044gcd	542	3	of	of	IN
cord-022594-fx044gcd	542	4	CSF	CSF	NNP
cord-022594-fx044gcd	542	5	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	542	6	is	be	VBZ
cord-022594-fx044gcd	542	7	IgG	igg	NN
cord-022594-fx044gcd	542	8	,	,	,
cord-022594-fx044gcd	542	9	although	although	IN
cord-022594-fx044gcd	542	10	IgM	IgM	NNP
cord-022594-fx044gcd	542	11	and	and	CC
cord-022594-fx044gcd	542	12	IgA	IgA	NNP
cord-022594-fx044gcd	542	13	may	may	MD
cord-022594-fx044gcd	542	14	also	also	RB
cord-022594-fx044gcd	542	15	be	be	VB
cord-022594-fx044gcd	542	16	elevated	elevate	VBN
cord-022594-fx044gcd	542	17	.	.	.
cord-022594-fx044gcd	543	1	Measures	measure	NNS
cord-022594-fx044gcd	543	2	of	of	IN
cord-022594-fx044gcd	543	3	intrathecal	intrathecal	JJ
cord-022594-fx044gcd	543	4	IgG	igg	NN
cord-022594-fx044gcd	543	5	production	production	NN
cord-022594-fx044gcd	543	6	have	have	VBP
cord-022594-fx044gcd	543	7	been	be	VBN
cord-022594-fx044gcd	543	8	devised	devise	VBN
cord-022594-fx044gcd	543	9	that	that	WDT
cord-022594-fx044gcd	543	10	are	be	VBP
cord-022594-fx044gcd	543	11	more	more	RBR
cord-022594-fx044gcd	543	12	useful	useful	JJ
cord-022594-fx044gcd	543	13	than	than	IN
cord-022594-fx044gcd	543	14	simple	simple	JJ
cord-022594-fx044gcd	543	15	g	g	NN
cord-022594-fx044gcd	543	16	-	-	HYPH
cord-022594-fx044gcd	543	17	globulin	globulin	NN
cord-022594-fx044gcd	543	18	levels	level	NNS
cord-022594-fx044gcd	543	19	.	.	.
cord-022594-fx044gcd	544	1	The	the	DT
cord-022594-fx044gcd	544	2	IgG	igg	NN
cord-022594-fx044gcd	544	3	index	index	NN
cord-022594-fx044gcd	544	4	and	and	CC
cord-022594-fx044gcd	544	5	synthesis	synthesis	NN
cord-022594-fx044gcd	544	6	rate	rate	NN
cord-022594-fx044gcd	544	7	are	be	VBP
cord-022594-fx044gcd	544	8	elevated	elevate	VBN
cord-022594-fx044gcd	544	9	in	in	IN
cord-022594-fx044gcd	544	10	70	70	CD
cord-022594-fx044gcd	544	11	%	%	NN
cord-022594-fx044gcd	544	12	to	to	TO
cord-022594-fx044gcd	544	13	90	90	CD
cord-022594-fx044gcd	544	14	%	%	NN
cord-022594-fx044gcd	544	15	of	of	IN
cord-022594-fx044gcd	544	16	CDMS	CDMS	NNP
cord-022594-fx044gcd	544	17	patients	patient	NNS
cord-022594-fx044gcd	544	18	and	and	CC
cord-022594-fx044gcd	544	19	occasionally	occasionally	RB
cord-022594-fx044gcd	544	20	in	in	IN
cord-022594-fx044gcd	544	21	other	other	JJ
cord-022594-fx044gcd	544	22	disorders	disorder	NNS
cord-022594-fx044gcd	544	23	.	.	.
cord-022594-fx044gcd	545	1	Agarose	Agarose	NNP
cord-022594-fx044gcd	545	2	gel	gel	NN
cord-022594-fx044gcd	545	3	electrophoresis	electrophoresis	NN
cord-022594-fx044gcd	545	4	,	,	,
cord-022594-fx044gcd	545	5	or	or	CC
cord-022594-fx044gcd	545	6	the	the	DT
cord-022594-fx044gcd	545	7	more	more	RBR
cord-022594-fx044gcd	545	8	sensitive	sensitive	JJ
cord-022594-fx044gcd	545	9	isoelectric	isoelectric	JJ
cord-022594-fx044gcd	545	10	focusing	focus	VBG
cord-022594-fx044gcd	545	11	of	of	IN
cord-022594-fx044gcd	545	12	CSF	csf	NN
cord-022594-fx044gcd	545	13	proteins	protein	NNS
cord-022594-fx044gcd	545	14	,	,	,
cord-022594-fx044gcd	545	15	often	often	RB
cord-022594-fx044gcd	545	16	reveals	reveal	VBZ
cord-022594-fx044gcd	545	17	discrete	discrete	JJ
cord-022594-fx044gcd	545	18	bands	band	NNS
cord-022594-fx044gcd	545	19	of	of	IN
cord-022594-fx044gcd	545	20	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	545	21	,	,	,
cord-022594-fx044gcd	545	22	each	each	DT
cord-022594-fx044gcd	545	23	a	a	DT
cord-022594-fx044gcd	545	24	monoclonal	monoclonal	JJ
cord-022594-fx044gcd	545	25	antibody	antibody	NN
cord-022594-fx044gcd	545	26	.	.	.
cord-022594-fx044gcd	546	1	It	-PRON-	PRP
cord-022594-fx044gcd	546	2	is	be	VBZ
cord-022594-fx044gcd	546	3	pertinent	pertinent	JJ
cord-022594-fx044gcd	546	4	to	to	TO
cord-022594-fx044gcd	546	5	compare	compare	VB
cord-022594-fx044gcd	546	6	serum	serum	NN
cord-022594-fx044gcd	546	7	and	and	CC
cord-022594-fx044gcd	546	8	CSF	csf	NN
cord-022594-fx044gcd	546	9	banding	banding	NN
cord-022594-fx044gcd	546	10	patterns	pattern	NNS
cord-022594-fx044gcd	546	11	because	because	IN
cord-022594-fx044gcd	546	12	peripheral	peripheral	JJ
cord-022594-fx044gcd	546	13	monoclonal	monoclonal	JJ
cord-022594-fx044gcd	546	14	gammopathies	gammopathy	NNS
cord-022594-fx044gcd	546	15	may	may	MD
cord-022594-fx044gcd	546	16	produce	produce	VB
cord-022594-fx044gcd	546	17	CSF	CSF	NNP
cord-022594-fx044gcd	546	18	bands	band	NNS
cord-022594-fx044gcd	546	19	.	.	.
cord-022594-fx044gcd	547	1	To	to	TO
cord-022594-fx044gcd	547	2	reduce	reduce	VB
cord-022594-fx044gcd	547	3	false	false	JJ
cord-022594-fx044gcd	547	4	-	-	HYPH
cord-022594-fx044gcd	547	5	positive	positive	JJ
cord-022594-fx044gcd	547	6	results	result	NNS
cord-022594-fx044gcd	547	7	,	,	,
cord-022594-fx044gcd	547	8	only	only	RB
cord-022594-fx044gcd	547	9	unique	unique	JJ
cord-022594-fx044gcd	547	10	CSF	CSF	NNP
cord-022594-fx044gcd	547	11	OCBs	ocb	NNS
cord-022594-fx044gcd	547	12	should	should	MD
cord-022594-fx044gcd	547	13	be	be	VB
cord-022594-fx044gcd	547	14	reported	report	VBN
cord-022594-fx044gcd	547	15	.	.	.
cord-022594-fx044gcd	548	1	Between	between	IN
cord-022594-fx044gcd	548	2	85	85	CD
cord-022594-fx044gcd	548	3	%	%	NN
cord-022594-fx044gcd	548	4	and	and	CC
cord-022594-fx044gcd	548	5	95	95	CD
cord-022594-fx044gcd	548	6	%	%	NN
cord-022594-fx044gcd	548	7	of	of	IN
cord-022594-fx044gcd	548	8	clinically	clinically	RB
cord-022594-fx044gcd	548	9	definite	definite	JJ
cord-022594-fx044gcd	548	10	MS	MS	NNP
cord-022594-fx044gcd	548	11	patients	patient	NNS
cord-022594-fx044gcd	548	12	have	have	VBP
cord-022594-fx044gcd	548	13	OCBs	ocb	NNS
cord-022594-fx044gcd	548	14	;	;	:
cord-022594-fx044gcd	548	15	however	however	RB
cord-022594-fx044gcd	548	16	,	,	,
cord-022594-fx044gcd	548	17	early	early	RB
cord-022594-fx044gcd	548	18	in	in	IN
cord-022594-fx044gcd	548	19	the	the	DT
cord-022594-fx044gcd	548	20	course	course	NN
cord-022594-fx044gcd	548	21	they	-PRON-	PRP
cord-022594-fx044gcd	548	22	are	be	VBP
cord-022594-fx044gcd	548	23	not	not	RB
cord-022594-fx044gcd	548	24	as	as	RB
cord-022594-fx044gcd	548	25	prevalent	prevalent	JJ
cord-022594-fx044gcd	548	26	.	.	.
cord-022594-fx044gcd	549	1	Once	once	IN
cord-022594-fx044gcd	549	2	present	present	JJ
cord-022594-fx044gcd	549	3	,	,	,
cord-022594-fx044gcd	549	4	OCBs	ocb	NNS
cord-022594-fx044gcd	549	5	persist	persist	VBP
cord-022594-fx044gcd	549	6	and	and	CC
cord-022594-fx044gcd	549	7	the	the	DT
cord-022594-fx044gcd	549	8	pattern	pattern	NN
cord-022594-fx044gcd	549	9	does	do	VBZ
cord-022594-fx044gcd	549	10	not	not	RB
cord-022594-fx044gcd	549	11	vary	vary	VB
cord-022594-fx044gcd	549	12	,	,	,
cord-022594-fx044gcd	549	13	although	although	IN
cord-022594-fx044gcd	549	14	new	new	JJ
cord-022594-fx044gcd	549	15	bands	band	NNS
cord-022594-fx044gcd	549	16	occasionally	occasionally	RB
cord-022594-fx044gcd	549	17	appear	appear	VBP
cord-022594-fx044gcd	549	18	.	.	.
cord-022594-fx044gcd	550	1	Unlike	unlike	IN
cord-022594-fx044gcd	550	2	subacute	subacute	JJ
cord-022594-fx044gcd	550	3	sclerosing	sclerosing	NN
cord-022594-fx044gcd	550	4	panencephalitis	panencephalitis	NN
cord-022594-fx044gcd	550	5	,	,	,
cord-022594-fx044gcd	550	6	in	in	IN
cord-022594-fx044gcd	550	7	which	which	WDT
cord-022594-fx044gcd	550	8	the	the	DT
cord-022594-fx044gcd	550	9	majority	majority	NN
cord-022594-fx044gcd	550	10	of	of	IN
cord-022594-fx044gcd	550	11	OCBs	OCBs	NNP
cord-022594-fx044gcd	550	12	are	be	VBP
cord-022594-fx044gcd	550	13	antibodies	antibody	NNS
cord-022594-fx044gcd	550	14	specific	specific	JJ
cord-022594-fx044gcd	550	15	for	for	IN
cord-022594-fx044gcd	550	16	measles	measle	NNS
cord-022594-fx044gcd	550	17	virus	virus	NN
cord-022594-fx044gcd	550	18	,	,	,
cord-022594-fx044gcd	550	19	the	the	DT
cord-022594-fx044gcd	550	20	antigenic	antigenic	JJ
cord-022594-fx044gcd	550	21	specificity	specificity	NN
cord-022594-fx044gcd	550	22	of	of	IN
cord-022594-fx044gcd	550	23	OCBs	OCBs	NNP
cord-022594-fx044gcd	550	24	in	in	IN
cord-022594-fx044gcd	550	25	MS	MS	NNP
cord-022594-fx044gcd	550	26	is	be	VBZ
cord-022594-fx044gcd	550	27	unknown	unknown	JJ
cord-022594-fx044gcd	550	28	;	;	:
cord-022594-fx044gcd	550	29	they	-PRON-	PRP
cord-022594-fx044gcd	550	30	are	be	VBP
cord-022594-fx044gcd	550	31	unlikely	unlikely	JJ
cord-022594-fx044gcd	550	32	to	to	TO
cord-022594-fx044gcd	550	33	be	be	VB
cord-022594-fx044gcd	550	34	pathogen	pathogen	NN
cord-022594-fx044gcd	550	35	specific	specific	JJ
cord-022594-fx044gcd	550	36	or	or	CC
cord-022594-fx044gcd	550	37	autoantigen	autoantigen	NN
cord-022594-fx044gcd	550	38	directed	direct	VBN
cord-022594-fx044gcd	550	39	;	;	:
cord-022594-fx044gcd	550	40	there	there	EX
cord-022594-fx044gcd	550	41	is	be	VBZ
cord-022594-fx044gcd	550	42	some	some	DT
cord-022594-fx044gcd	550	43	evidence	evidence	NN
cord-022594-fx044gcd	550	44	that	that	IN
cord-022594-fx044gcd	550	45	they	-PRON-	PRP
cord-022594-fx044gcd	550	46	may	may	MD
cord-022594-fx044gcd	550	47	be	be	VB
cord-022594-fx044gcd	550	48	genetically	genetically	RB
cord-022594-fx044gcd	550	49	determined	determine	VBN
cord-022594-fx044gcd	550	50	germline	germline	JJ
cord-022594-fx044gcd	550	51	antibodies	antibody	NNS
cord-022594-fx044gcd	550	52	.	.	.
cord-022594-fx044gcd	551	1	Five	five	CD
cord-022594-fx044gcd	551	2	percent	percent	NN
cord-022594-fx044gcd	551	3	to	to	IN
cord-022594-fx044gcd	551	4	10	10	CD
cord-022594-fx044gcd	551	5	%	%	NN
cord-022594-fx044gcd	551	6	of	of	IN
cord-022594-fx044gcd	551	7	noninflammatory	noninflammatory	JJ
cord-022594-fx044gcd	551	8	CNS	CNS	NNP
cord-022594-fx044gcd	551	9	samples	sample	NNS
cord-022594-fx044gcd	551	10	and	and	CC
cord-022594-fx044gcd	551	11	30	30	CD
cord-022594-fx044gcd	551	12	%	%	NN
cord-022594-fx044gcd	551	13	of	of	IN
cord-022594-fx044gcd	551	14	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	551	15	samples	sample	NNS
cord-022594-fx044gcd	551	16	are	be	VBP
cord-022594-fx044gcd	551	17	also	also	RB
cord-022594-fx044gcd	551	18	positive	positive	JJ
cord-022594-fx044gcd	551	19	for	for	IN
cord-022594-fx044gcd	551	20	OCBs	ocb	NNS
cord-022594-fx044gcd	551	21	.	.	.
cord-022594-fx044gcd	552	1	51	51	CD
cord-022594-fx044gcd	552	2	More	more	RBR
cord-022594-fx044gcd	552	3	detailed	detailed	JJ
cord-022594-fx044gcd	552	4	recommendations	recommendation	NNS
cord-022594-fx044gcd	552	5	about	about	IN
cord-022594-fx044gcd	552	6	the	the	DT
cord-022594-fx044gcd	552	7	inclusion	inclusion	NN
cord-022594-fx044gcd	552	8	of	of	IN
cord-022594-fx044gcd	552	9	CSF	csf	NN
cord-022594-fx044gcd	552	10	parameters	parameter	NNS
cord-022594-fx044gcd	552	11	to	to	IN
cord-022594-fx044gcd	552	12	the	the	DT
cord-022594-fx044gcd	552	13	diagnosis	diagnosis	NN
cord-022594-fx044gcd	552	14	of	of	IN
cord-022594-fx044gcd	552	15	MS	MS	NNP
cord-022594-fx044gcd	552	16	were	be	VBD
cord-022594-fx044gcd	552	17	recently	recently	RB
cord-022594-fx044gcd	552	18	published	publish	VBN
cord-022594-fx044gcd	552	19	52	52	CD
cord-022594-fx044gcd	552	20	suggesting	suggest	VBG
cord-022594-fx044gcd	552	21	that	that	IN
cord-022594-fx044gcd	552	22	the	the	DT
cord-022594-fx044gcd	552	23	cell	cell	NN
cord-022594-fx044gcd	552	24	count	count	NN
cord-022594-fx044gcd	552	25	and	and	CC
cord-022594-fx044gcd	552	26	differential	differential	NN
cord-022594-fx044gcd	552	27	should	should	MD
cord-022594-fx044gcd	552	28	be	be	VB
cord-022594-fx044gcd	552	29	completed	complete	VBN
cord-022594-fx044gcd	552	30	within	within	IN
cord-022594-fx044gcd	552	31	2	2	CD
cord-022594-fx044gcd	552	32	hours	hour	NNS
cord-022594-fx044gcd	552	33	.	.	.
cord-022594-fx044gcd	553	1	The	the	DT
cord-022594-fx044gcd	553	2	new	new	JJ
cord-022594-fx044gcd	553	3	and	and	CC
cord-022594-fx044gcd	553	4	recommended	recommended	JJ
cord-022594-fx044gcd	553	5	method	method	NN
cord-022594-fx044gcd	553	6	for	for	IN
cord-022594-fx044gcd	553	7	the	the	DT
cord-022594-fx044gcd	553	8	detection	detection	NN
cord-022594-fx044gcd	553	9	of	of	IN
cord-022594-fx044gcd	553	10	OCBs	OCBs	NNP
cord-022594-fx044gcd	553	11	includes	include	VBZ
cord-022594-fx044gcd	553	12	immunoelectophorsesis	immunoelectophorsesis	NNP
cord-022594-fx044gcd	553	13	on	on	IN
cord-022594-fx044gcd	553	14	agarose	agarose	JJ
cord-022594-fx044gcd	553	15	gel	gel	NN
cord-022594-fx044gcd	553	16	followed	follow	VBN
cord-022594-fx044gcd	553	17	by	by	IN
cord-022594-fx044gcd	553	18	immunoblotting	immunoblotte	VBG
cord-022594-fx044gcd	553	19	.	.	.
cord-022594-fx044gcd	554	1	The	the	DT
cord-022594-fx044gcd	554	2	reported	reported	JJ
cord-022594-fx044gcd	554	3	sensitivity	sensitivity	NN
cord-022594-fx044gcd	554	4	of	of	IN
cord-022594-fx044gcd	554	5	this	this	DT
cord-022594-fx044gcd	554	6	technique	technique	NN
cord-022594-fx044gcd	554	7	is	be	VBZ
cord-022594-fx044gcd	554	8	above	above	IN
cord-022594-fx044gcd	554	9	95	95	CD
cord-022594-fx044gcd	554	10	%	%	NN
cord-022594-fx044gcd	554	11	,	,	,
cord-022594-fx044gcd	554	12	with	with	IN
cord-022594-fx044gcd	554	13	a	a	DT
cord-022594-fx044gcd	554	14	specificity	specificity	NN
cord-022594-fx044gcd	554	15	of	of	IN
cord-022594-fx044gcd	554	16	86	86	CD
cord-022594-fx044gcd	554	17	%	%	NN
cord-022594-fx044gcd	554	18	to	to	IN
cord-022594-fx044gcd	554	19	87	87	CD
cord-022594-fx044gcd	554	20	%	%	NN
cord-022594-fx044gcd	554	21	.	.	.
cord-022594-fx044gcd	555	1	In	in	IN
cord-022594-fx044gcd	555	2	other	other	JJ
cord-022594-fx044gcd	555	3	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	555	4	or	or	CC
cord-022594-fx044gcd	555	5	infectious	infectious	JJ
cord-022594-fx044gcd	555	6	illnesses	illness	NNS
cord-022594-fx044gcd	555	7	,	,	,
cord-022594-fx044gcd	555	8	OCBs	ocb	NNS
cord-022594-fx044gcd	555	9	are	be	VBP
cord-022594-fx044gcd	555	10	often	often	RB
cord-022594-fx044gcd	555	11	transient	transient	JJ
cord-022594-fx044gcd	555	12	features	feature	NNS
cord-022594-fx044gcd	555	13	.	.	.
cord-022594-fx044gcd	556	1	Their	-PRON-	PRP$
cord-022594-fx044gcd	556	2	persistence	persistence	NN
cord-022594-fx044gcd	556	3	is	be	VBZ
cord-022594-fx044gcd	556	4	more	more	RBR
cord-022594-fx044gcd	556	5	suggestive	suggestive	JJ
cord-022594-fx044gcd	556	6	of	of	IN
cord-022594-fx044gcd	556	7	MS	MS	NNP
cord-022594-fx044gcd	556	8	.	.	.
cord-022594-fx044gcd	557	1	The	the	DT
cord-022594-fx044gcd	557	2	presence	presence	NN
cord-022594-fx044gcd	557	3	of	of	IN
cord-022594-fx044gcd	557	4	myelin	myelin	NN
cord-022594-fx044gcd	557	5	components	component	NNS
cord-022594-fx044gcd	557	6	,	,	,
cord-022594-fx044gcd	557	7	antimyelin	antimyelin	NN
cord-022594-fx044gcd	557	8	antibodies	antibody	NNS
cord-022594-fx044gcd	557	9	,	,	,
cord-022594-fx044gcd	557	10	and	and	CC
cord-022594-fx044gcd	557	11	kappa	kappa	NN
cord-022594-fx044gcd	557	12	light	light	NN
cord-022594-fx044gcd	557	13	chains	chain	NNS
cord-022594-fx044gcd	557	14	in	in	IN
cord-022594-fx044gcd	557	15	CSF	CSF	NNP
cord-022594-fx044gcd	557	16	has	have	VBZ
cord-022594-fx044gcd	557	17	also	also	RB
cord-022594-fx044gcd	557	18	been	be	VBN
cord-022594-fx044gcd	557	19	used	use	VBN
cord-022594-fx044gcd	557	20	in	in	IN
cord-022594-fx044gcd	557	21	the	the	DT
cord-022594-fx044gcd	557	22	diagnosis	diagnosis	NN
cord-022594-fx044gcd	557	23	of	of	IN
cord-022594-fx044gcd	557	24	MS	MS	NNP
cord-022594-fx044gcd	557	25	.	.	.
cord-022594-fx044gcd	558	1	However	however	RB
cord-022594-fx044gcd	558	2	,	,	,
cord-022594-fx044gcd	558	3	the	the	DT
cord-022594-fx044gcd	558	4	sensitivity	sensitivity	NN
cord-022594-fx044gcd	558	5	and	and	CC
cord-022594-fx044gcd	558	6	specificity	specificity	NN
cord-022594-fx044gcd	558	7	of	of	IN
cord-022594-fx044gcd	558	8	these	these	DT
cord-022594-fx044gcd	558	9	products	product	NNS
cord-022594-fx044gcd	558	10	is	be	VBZ
cord-022594-fx044gcd	558	11	less	less	JJR
cord-022594-fx044gcd	558	12	than	than	IN
cord-022594-fx044gcd	558	13	that	that	DT
cord-022594-fx044gcd	558	14	of	of	IN
cord-022594-fx044gcd	558	15	OCBs	ocb	NNS
cord-022594-fx044gcd	558	16	.	.	.
cord-022594-fx044gcd	559	1	In	in	IN
cord-022594-fx044gcd	559	2	late	late	JJ
cord-022594-fx044gcd	559	3	2005	2005	CD
cord-022594-fx044gcd	559	4	,	,	,
cord-022594-fx044gcd	559	5	a	a	DT
cord-022594-fx044gcd	559	6	new	new	JJ
cord-022594-fx044gcd	559	7	set	set	NN
cord-022594-fx044gcd	559	8	of	of	IN
cord-022594-fx044gcd	559	9	recommendations	recommendation	NNS
cord-022594-fx044gcd	559	10	were	be	VBD
cord-022594-fx044gcd	559	11	published	publish	VBN
cord-022594-fx044gcd	559	12	based	base	VBN
cord-022594-fx044gcd	559	13	on	on	IN
cord-022594-fx044gcd	559	14	the	the	DT
cord-022594-fx044gcd	559	15	first	first	JJ
cord-022594-fx044gcd	559	16	5	5	CD
cord-022594-fx044gcd	559	17	years	year	NNS
cord-022594-fx044gcd	559	18	of	of	IN
cord-022594-fx044gcd	559	19	using	use	VBG
cord-022594-fx044gcd	559	20	McDonald	McDonald	NNP
cord-022594-fx044gcd	559	21	's	's	POS
cord-022594-fx044gcd	559	22	criteria	criterion	NNS
cord-022594-fx044gcd	559	23	in	in	IN
cord-022594-fx044gcd	559	24	diagnosing	diagnose	VBG
cord-022594-fx044gcd	559	25	MS	MS	NNP
cord-022594-fx044gcd	559	26	.	.	.
cord-022594-fx044gcd	560	1	53	53	CD
cord-022594-fx044gcd	561	1	The	the	DT
cord-022594-fx044gcd	561	2	original	original	JJ
cord-022594-fx044gcd	561	3	McDonald	McDonald	NNP
cord-022594-fx044gcd	561	4	Criteria	Criteria	NNP
cord-022594-fx044gcd	561	5	have	have	VBP
cord-022594-fx044gcd	561	6	been	be	VBN
cord-022594-fx044gcd	561	7	incorrectly	incorrectly	RB
cord-022594-fx044gcd	561	8	interpreted	interpret	VBN
cord-022594-fx044gcd	561	9	by	by	IN
cord-022594-fx044gcd	561	10	some	some	DT
cord-022594-fx044gcd	561	11	as	as	IN
cord-022594-fx044gcd	561	12	mainly	mainly	RB
cord-022594-fx044gcd	561	13	relying	rely	VBG
cord-022594-fx044gcd	561	14	on	on	IN
cord-022594-fx044gcd	561	15	MRI	MRI	NNP
cord-022594-fx044gcd	561	16	for	for	IN
cord-022594-fx044gcd	561	17	making	make	VBG
cord-022594-fx044gcd	561	18	a	a	DT
cord-022594-fx044gcd	561	19	diagnosis	diagnosis	NN
cord-022594-fx044gcd	561	20	of	of	IN
cord-022594-fx044gcd	561	21	MS	MS	NNP
cord-022594-fx044gcd	561	22	.	.	.
cord-022594-fx044gcd	562	1	In	in	IN
cord-022594-fx044gcd	562	2	reality	reality	NN
cord-022594-fx044gcd	562	3	,	,	,
cord-022594-fx044gcd	562	4	the	the	DT
cord-022594-fx044gcd	562	5	McDonald	McDonald	NNP
cord-022594-fx044gcd	562	6	Criteria	Criteria	NNP
cord-022594-fx044gcd	562	7	can	can	MD
cord-022594-fx044gcd	562	8	not	not	RB
cord-022594-fx044gcd	562	9	even	even	RB
cord-022594-fx044gcd	562	10	be	be	VB
cord-022594-fx044gcd	562	11	applied	apply	VBN
cord-022594-fx044gcd	562	12	without	without	IN
cord-022594-fx044gcd	562	13	careful	careful	JJ
cord-022594-fx044gcd	562	14	clinical	clinical	JJ
cord-022594-fx044gcd	562	15	evaluation	evaluation	NN
cord-022594-fx044gcd	562	16	of	of	IN
cord-022594-fx044gcd	562	17	the	the	DT
cord-022594-fx044gcd	562	18	patient	patient	NN
cord-022594-fx044gcd	562	19	.	.	.
cord-022594-fx044gcd	563	1	Neurological	neurological	JJ
cord-022594-fx044gcd	563	2	deficits	deficit	NNS
cord-022594-fx044gcd	563	3	must	must	MD
cord-022594-fx044gcd	563	4	be	be	VB
cord-022594-fx044gcd	563	5	evident	evident	JJ
cord-022594-fx044gcd	563	6	to	to	IN
cord-022594-fx044gcd	563	7	the	the	DT
cord-022594-fx044gcd	563	8	examiner	examiner	NN
cord-022594-fx044gcd	563	9	,	,	,
cord-022594-fx044gcd	563	10	and	and	CC
cord-022594-fx044gcd	563	11	must	must	MD
cord-022594-fx044gcd	563	12	be	be	VB
cord-022594-fx044gcd	563	13	suggestive	suggestive	JJ
cord-022594-fx044gcd	563	14	of	of	IN
cord-022594-fx044gcd	563	15	MS	MS	NNP
cord-022594-fx044gcd	563	16	.	.	.
cord-022594-fx044gcd	564	1	Scans	scan	NNS
cord-022594-fx044gcd	564	2	that	that	IN
cord-022594-fx044gcd	564	3	"	"	``
cord-022594-fx044gcd	564	4	look	look	VB
cord-022594-fx044gcd	564	5	like	like	IN
cord-022594-fx044gcd	564	6	"	"	``
cord-022594-fx044gcd	564	7	MS	MS	NNP
cord-022594-fx044gcd	564	8	(	(	-LRB-
cord-022594-fx044gcd	564	9	and	and	CC
cord-022594-fx044gcd	564	10	meet	meet	VB
cord-022594-fx044gcd	564	11	the	the	DT
cord-022594-fx044gcd	564	12	criteria	criterion	NNS
cord-022594-fx044gcd	564	13	of	of	IN
cord-022594-fx044gcd	564	14	Barkhof	Barkhof	NNP
cord-022594-fx044gcd	564	15	and	and	CC
cord-022594-fx044gcd	564	16	Tintore	Tintore	NNP
cord-022594-fx044gcd	564	17	)	)	-RRB-
cord-022594-fx044gcd	564	18	but	but	CC
cord-022594-fx044gcd	564	19	have	have	VBP
cord-022594-fx044gcd	564	20	never	never	RB
cord-022594-fx044gcd	564	21	been	be	VBN
cord-022594-fx044gcd	564	22	accompanied	accompany	VBN
cord-022594-fx044gcd	564	23	by	by	IN
cord-022594-fx044gcd	564	24	an	an	DT
cord-022594-fx044gcd	564	25	obvious	obvious	JJ
cord-022594-fx044gcd	564	26	and	and	CC
cord-022594-fx044gcd	564	27	documented	document	VBN
cord-022594-fx044gcd	564	28	neurological	neurological	JJ
cord-022594-fx044gcd	564	29	examination	examination	NN
cord-022594-fx044gcd	564	30	finding	finding	NN
cord-022594-fx044gcd	564	31	do	do	VBP
cord-022594-fx044gcd	564	32	not	not	RB
cord-022594-fx044gcd	564	33	fulfill	fulfill	VB
cord-022594-fx044gcd	564	34	the	the	DT
cord-022594-fx044gcd	564	35	McDonald	McDonald	NNP
cord-022594-fx044gcd	564	36	Criteria	Criteria	NNP
cord-022594-fx044gcd	564	37	.	.	.
cord-022594-fx044gcd	565	1	There	there	EX
cord-022594-fx044gcd	565	2	was	be	VBD
cord-022594-fx044gcd	565	3	some	some	DT
cord-022594-fx044gcd	565	4	sympathy	sympathy	NN
cord-022594-fx044gcd	565	5	among	among	IN
cord-022594-fx044gcd	565	6	the	the	DT
cord-022594-fx044gcd	565	7	International	International	NNP
cord-022594-fx044gcd	565	8	Panel	Panel	NNP
cord-022594-fx044gcd	565	9	members	member	NNS
cord-022594-fx044gcd	565	10	revising	revise	VBG
cord-022594-fx044gcd	565	11	the	the	DT
cord-022594-fx044gcd	565	12	McDonald	McDonald	NNP
cord-022594-fx044gcd	565	13	Criteria	Criteria	NNP
cord-022594-fx044gcd	565	14	to	to	TO
cord-022594-fx044gcd	565	15	allow	allow	VB
cord-022594-fx044gcd	565	16	selected	select	VBN
cord-022594-fx044gcd	565	17	symptoms	symptom	NNS
cord-022594-fx044gcd	565	18	that	that	WDT
cord-022594-fx044gcd	565	19	are	be	VBP
cord-022594-fx044gcd	565	20	clearly	clearly	RB
cord-022594-fx044gcd	565	21	and	and	CC
cord-022594-fx044gcd	565	22	specifically	specifically	RB
cord-022594-fx044gcd	565	23	enunciated	enunciate	VBN
cord-022594-fx044gcd	565	24	by	by	IN
cord-022594-fx044gcd	565	25	the	the	DT
cord-022594-fx044gcd	565	26	patient	patient	NN
cord-022594-fx044gcd	565	27	(	(	-LRB-
cord-022594-fx044gcd	565	28	e.g.	e.g.	RB
cord-022594-fx044gcd	565	29	,	,	,
cord-022594-fx044gcd	565	30	Lhermitte	Lhermitte	NNP
cord-022594-fx044gcd	565	31	's	's	POS
cord-022594-fx044gcd	565	32	symptom	symptom	NN
cord-022594-fx044gcd	565	33	,	,	,
cord-022594-fx044gcd	565	34	trigeminal	trigeminal	JJ
cord-022594-fx044gcd	565	35	neuralgia	neuralgia	NN
cord-022594-fx044gcd	565	36	,	,	,
cord-022594-fx044gcd	565	37	numbness	numbness	NN
cord-022594-fx044gcd	565	38	ascending	ascend	VBG
cord-022594-fx044gcd	565	39	to	to	IN
cord-022594-fx044gcd	565	40	the	the	DT
cord-022594-fx044gcd	565	41	waist	waist	NN
cord-022594-fx044gcd	565	42	or	or	CC
cord-022594-fx044gcd	565	43	higher	high	JJR
cord-022594-fx044gcd	565	44	)	)	-RRB-
cord-022594-fx044gcd	565	45	coupled	couple	VBN
cord-022594-fx044gcd	565	46	with	with	IN
cord-022594-fx044gcd	565	47	objective	objective	JJ
cord-022594-fx044gcd	565	48	paraclinical	paraclinical	NN
cord-022594-fx044gcd	565	49	(	(	-LRB-
cord-022594-fx044gcd	565	50	such	such	JJ
cord-022594-fx044gcd	565	51	as	as	IN
cord-022594-fx044gcd	565	52	imaging	imaging	NN
cord-022594-fx044gcd	565	53	and	and	CC
cord-022594-fx044gcd	565	54	CSF	CSF	NNP
cord-022594-fx044gcd	565	55	)	)	-RRB-
cord-022594-fx044gcd	565	56	findings	finding	NNS
cord-022594-fx044gcd	565	57	to	to	TO
cord-022594-fx044gcd	565	58	be	be	VB
cord-022594-fx044gcd	565	59	sufficient	sufficient	JJ
cord-022594-fx044gcd	565	60	as	as	IN
cord-022594-fx044gcd	565	61	an	an	DT
cord-022594-fx044gcd	565	62	indicator	indicator	NN
cord-022594-fx044gcd	565	63	of	of	IN
cord-022594-fx044gcd	565	64	a	a	DT
cord-022594-fx044gcd	565	65	prior	prior	JJ
cord-022594-fx044gcd	565	66	or	or	CC
cord-022594-fx044gcd	565	67	current	current	JJ
cord-022594-fx044gcd	565	68	attack	attack	NN
cord-022594-fx044gcd	565	69	needed	need	VBN
cord-022594-fx044gcd	565	70	for	for	IN
cord-022594-fx044gcd	565	71	an	an	DT
cord-022594-fx044gcd	565	72	MS	MS	NNP
cord-022594-fx044gcd	565	73	diagnosis	diagnosis	NN
cord-022594-fx044gcd	565	74	.	.	.
cord-022594-fx044gcd	566	1	However	however	RB
cord-022594-fx044gcd	566	2	,	,	,
cord-022594-fx044gcd	566	3	the	the	DT
cord-022594-fx044gcd	566	4	panel	panel	NN
cord-022594-fx044gcd	566	5	was	be	VBD
cord-022594-fx044gcd	566	6	reluctant	reluctant	JJ
cord-022594-fx044gcd	566	7	to	to	TO
cord-022594-fx044gcd	566	8	endorse	endorse	VB
cord-022594-fx044gcd	566	9	the	the	DT
cord-022594-fx044gcd	566	10	diagnosis	diagnosis	NN
cord-022594-fx044gcd	566	11	of	of	IN
cord-022594-fx044gcd	566	12	MS	MS	NNP
cord-022594-fx044gcd	566	13	in	in	IN
cord-022594-fx044gcd	566	14	the	the	DT
cord-022594-fx044gcd	566	15	absence	absence	NN
cord-022594-fx044gcd	566	16	of	of	IN
cord-022594-fx044gcd	566	17	any	any	DT
cord-022594-fx044gcd	566	18	objective	objective	JJ
cord-022594-fx044gcd	566	19	clinical	clinical	JJ
cord-022594-fx044gcd	566	20	findings	finding	NNS
cord-022594-fx044gcd	566	21	,	,	,
cord-022594-fx044gcd	566	22	even	even	RB
cord-022594-fx044gcd	566	23	if	if	IN
cord-022594-fx044gcd	566	24	objective	objective	JJ
cord-022594-fx044gcd	566	25	paraclinical	paraclinical	JJ
cord-022594-fx044gcd	566	26	findings	finding	NNS
cord-022594-fx044gcd	566	27	are	be	VBP
cord-022594-fx044gcd	566	28	in	in	IN
cord-022594-fx044gcd	566	29	place	place	NN
cord-022594-fx044gcd	566	30	,	,	,
cord-022594-fx044gcd	566	31	at	at	IN
cord-022594-fx044gcd	566	32	least	least	JJS
cord-022594-fx044gcd	566	33	until	until	IN
cord-022594-fx044gcd	566	34	such	such	PDT
cord-022594-fx044gcd	566	35	a	a	DT
cord-022594-fx044gcd	566	36	scheme	scheme	NN
cord-022594-fx044gcd	566	37	is	be	VBZ
cord-022594-fx044gcd	566	38	tested	test	VBN
cord-022594-fx044gcd	566	39	in	in	IN
cord-022594-fx044gcd	566	40	prospective	prospective	JJ
cord-022594-fx044gcd	566	41	settings	setting	NNS
cord-022594-fx044gcd	566	42	.	.	.
cord-022594-fx044gcd	567	1	Patients	patient	NNS
cord-022594-fx044gcd	567	2	with	with	IN
cord-022594-fx044gcd	567	3	imaging	imaging	NN
cord-022594-fx044gcd	567	4	and	and	CC
cord-022594-fx044gcd	567	5	CSF	CSF	NNP
cord-022594-fx044gcd	567	6	findings	finding	NNS
cord-022594-fx044gcd	567	7	suggestive	suggestive	JJ
cord-022594-fx044gcd	567	8	of	of	IN
cord-022594-fx044gcd	567	9	MS	MS	NNP
cord-022594-fx044gcd	567	10	but	but	CC
cord-022594-fx044gcd	567	11	not	not	RB
cord-022594-fx044gcd	567	12	showing	show	VBG
cord-022594-fx044gcd	567	13	any	any	DT
cord-022594-fx044gcd	567	14	objective	objective	JJ
cord-022594-fx044gcd	567	15	evidence	evidence	NN
cord-022594-fx044gcd	567	16	for	for	IN
cord-022594-fx044gcd	567	17	neurological	neurological	JJ
cord-022594-fx044gcd	567	18	deficits	deficit	NNS
cord-022594-fx044gcd	567	19	commonly	commonly	RB
cord-022594-fx044gcd	567	20	seen	see	VBN
cord-022594-fx044gcd	567	21	in	in	IN
cord-022594-fx044gcd	567	22	MS	MS	NNP
cord-022594-fx044gcd	567	23	require	require	VBP
cord-022594-fx044gcd	567	24	careful	careful	JJ
cord-022594-fx044gcd	567	25	clinical	clinical	JJ
cord-022594-fx044gcd	567	26	and	and	CC
cord-022594-fx044gcd	567	27	radiological	radiological	JJ
cord-022594-fx044gcd	567	28	monitoring	monitoring	NN
cord-022594-fx044gcd	567	29	.	.	.
cord-022594-fx044gcd	568	1	Until	until	IN
cord-022594-fx044gcd	568	2	objective	objective	JJ
cord-022594-fx044gcd	568	3	evidence	evidence	NN
cord-022594-fx044gcd	568	4	for	for	IN
cord-022594-fx044gcd	568	5	neurological	neurological	JJ
cord-022594-fx044gcd	568	6	deficits	deficit	NNS
cord-022594-fx044gcd	568	7	are	be	VBP
cord-022594-fx044gcd	568	8	found	find	VBN
cord-022594-fx044gcd	568	9	,	,	,
cord-022594-fx044gcd	568	10	MS	MS	NNP
cord-022594-fx044gcd	568	11	can	can	MD
cord-022594-fx044gcd	568	12	not	not	RB
cord-022594-fx044gcd	568	13	be	be	VB
cord-022594-fx044gcd	568	14	diagnosed	diagnose	VBN
cord-022594-fx044gcd	568	15	.	.	.
cord-022594-fx044gcd	569	1	MS	MS	NNP
cord-022594-fx044gcd	569	2	may	may	MD
cord-022594-fx044gcd	569	3	be	be	VB
cord-022594-fx044gcd	569	4	the	the	DT
cord-022594-fx044gcd	569	5	correct	correct	JJ
cord-022594-fx044gcd	569	6	diagnosis	diagnosis	NN
cord-022594-fx044gcd	569	7	with	with	IN
cord-022594-fx044gcd	569	8	less	less	RBR
cord-022594-fx044gcd	569	9	stringent	stringent	JJ
cord-022594-fx044gcd	569	10	imaging	imaging	NN
cord-022594-fx044gcd	569	11	criteria	criterion	NNS
cord-022594-fx044gcd	569	12	than	than	IN
cord-022594-fx044gcd	569	13	originally	originally	RB
cord-022594-fx044gcd	569	14	proposed	propose	VBN
cord-022594-fx044gcd	569	15	;	;	:
cord-022594-fx044gcd	569	16	however	however	RB
cord-022594-fx044gcd	569	17	,	,	,
cord-022594-fx044gcd	569	18	the	the	DT
cord-022594-fx044gcd	569	19	panel	panel	NN
cord-022594-fx044gcd	569	20	was	be	VBD
cord-022594-fx044gcd	569	21	uncomfortable	uncomfortable	JJ
cord-022594-fx044gcd	569	22	making	make	VBG
cord-022594-fx044gcd	569	23	changes	change	NNS
cord-022594-fx044gcd	569	24	that	that	WDT
cord-022594-fx044gcd	569	25	would	would	MD
cord-022594-fx044gcd	569	26	allow	allow	VB
cord-022594-fx044gcd	569	27	MRI	MRI	NNP
cord-022594-fx044gcd	569	28	confirmation	confirmation	NN
cord-022594-fx044gcd	569	29	of	of	IN
cord-022594-fx044gcd	569	30	dissemination	dissemination	NN
cord-022594-fx044gcd	569	31	in	in	IN
cord-022594-fx044gcd	569	32	space	space	NN
cord-022594-fx044gcd	569	33	based	base	VBN
cord-022594-fx044gcd	569	34	on	on	IN
cord-022594-fx044gcd	569	35	lower	low	JJR
cord-022594-fx044gcd	569	36	stringency	stringency	NN
cord-022594-fx044gcd	569	37	imaging	imaging	NN
cord-022594-fx044gcd	569	38	criteria	criterion	NNS
cord-022594-fx044gcd	569	39	without	without	IN
cord-022594-fx044gcd	569	40	appropriate	appropriate	JJ
cord-022594-fx044gcd	569	41	prospective	prospective	JJ
cord-022594-fx044gcd	569	42	data	datum	NNS
cord-022594-fx044gcd	569	43	.	.	.
cord-022594-fx044gcd	570	1	Most	Most	JJS
cord-022594-fx044gcd	570	2	studies	study	NNS
cord-022594-fx044gcd	570	3	performed	perform	VBN
cord-022594-fx044gcd	570	4	to	to	IN
cord-022594-fx044gcd	570	5	date	date	NN
cord-022594-fx044gcd	570	6	have	have	VBP
cord-022594-fx044gcd	570	7	been	be	VBN
cord-022594-fx044gcd	570	8	inadequately	inadequately	RB
cord-022594-fx044gcd	570	9	designed	design	VBN
cord-022594-fx044gcd	570	10	to	to	TO
cord-022594-fx044gcd	570	11	address	address	VB
cord-022594-fx044gcd	570	12	this	this	DT
cord-022594-fx044gcd	570	13	issue	issue	NN
cord-022594-fx044gcd	570	14	.	.	.
cord-022594-fx044gcd	571	1	Advanced	advanced	JJ
cord-022594-fx044gcd	571	2	imaging	imaging	NN
cord-022594-fx044gcd	571	3	technologies	technology	NNS
cord-022594-fx044gcd	571	4	are	be	VBP
cord-022594-fx044gcd	571	5	constantly	constantly	RB
cord-022594-fx044gcd	571	6	evolving	evolve	VBG
cord-022594-fx044gcd	571	7	and	and	CC
cord-022594-fx044gcd	571	8	will	will	MD
cord-022594-fx044gcd	571	9	likely	likely	RB
cord-022594-fx044gcd	571	10	one	one	CD
cord-022594-fx044gcd	571	11	day	day	NN
cord-022594-fx044gcd	571	12	be	be	VB
cord-022594-fx044gcd	571	13	shown	show	VBN
cord-022594-fx044gcd	571	14	to	to	TO
cord-022594-fx044gcd	571	15	aid	aid	VB
cord-022594-fx044gcd	571	16	in	in	IN
cord-022594-fx044gcd	571	17	making	make	VBG
cord-022594-fx044gcd	571	18	the	the	DT
cord-022594-fx044gcd	571	19	diagnosis	diagnosis	NN
cord-022594-fx044gcd	571	20	of	of	IN
cord-022594-fx044gcd	571	21	MS	MS	NNP
cord-022594-fx044gcd	571	22	.	.	.
cord-022594-fx044gcd	572	1	Visualization	visualization	NN
cord-022594-fx044gcd	572	2	of	of	IN
cord-022594-fx044gcd	572	3	intracortical	intracortical	JJ
cord-022594-fx044gcd	572	4	lesions	lesion	NNS
cord-022594-fx044gcd	572	5	,	,	,
cord-022594-fx044gcd	572	6	use	use	NN
cord-022594-fx044gcd	572	7	of	of	IN
cord-022594-fx044gcd	572	8	higher	high	JJR
cord-022594-fx044gcd	572	9	field	field	NN
cord-022594-fx044gcd	572	10	strength	strength	NN
cord-022594-fx044gcd	572	11	magnets	magnet	NNS
cord-022594-fx044gcd	572	12	,	,	,
cord-022594-fx044gcd	572	13	and	and	CC
cord-022594-fx044gcd	572	14	analysis	analysis	NN
cord-022594-fx044gcd	572	15	of	of	IN
cord-022594-fx044gcd	572	16	"	"	``
cord-022594-fx044gcd	572	17	normal	normal	JJ
cord-022594-fx044gcd	572	18	appearing	appear	VBG
cord-022594-fx044gcd	572	19	brain	brain	NN
cord-022594-fx044gcd	572	20	tissue	tissue	NN
cord-022594-fx044gcd	572	21	,	,	,
cord-022594-fx044gcd	572	22	"	"	''
cord-022594-fx044gcd	572	23	may	may	MD
cord-022594-fx044gcd	572	24	be	be	VB
cord-022594-fx044gcd	572	25	conrnerstones	conrnerstone	NNS
cord-022594-fx044gcd	572	26	of	of	IN
cord-022594-fx044gcd	572	27	a	a	DT
cord-022594-fx044gcd	572	28	future	future	JJ
cord-022594-fx044gcd	572	29	MRI	MRI	NNP
cord-022594-fx044gcd	572	30	criteria	criterion	NNS
cord-022594-fx044gcd	572	31	for	for	IN
cord-022594-fx044gcd	572	32	MS	MS	NNP
cord-022594-fx044gcd	572	33	.	.	.
cord-022594-fx044gcd	573	1	Preliminary	preliminary	JJ
cord-022594-fx044gcd	573	2	evidence	evidence	NN
cord-022594-fx044gcd	573	3	suggests	suggest	VBZ
cord-022594-fx044gcd	573	4	that	that	IN
cord-022594-fx044gcd	573	5	"	"	``
cord-022594-fx044gcd	573	6	occult	occult	JJ
cord-022594-fx044gcd	573	7	"	"	''
cord-022594-fx044gcd	573	8	damage	damage	NN
cord-022594-fx044gcd	573	9	in	in	IN
cord-022594-fx044gcd	573	10	normalappearing	normalappeare	VBG
cord-022594-fx044gcd	573	11	white	white	JJ
cord-022594-fx044gcd	573	12	and	and	CC
cord-022594-fx044gcd	573	13	gray	gray	JJ
cord-022594-fx044gcd	573	14	matter	matter	NN
cord-022594-fx044gcd	573	15	seen	see	VBN
cord-022594-fx044gcd	573	16	with	with	IN
cord-022594-fx044gcd	573	17	magnetization	magnetization	NN
cord-022594-fx044gcd	573	18	transfer	transfer	NN
cord-022594-fx044gcd	573	19	,	,	,
cord-022594-fx044gcd	573	20	diffusion	diffusion	NN
cord-022594-fx044gcd	573	21	tensor	tensor	NN
cord-022594-fx044gcd	573	22	imaging	imaging	NN
cord-022594-fx044gcd	573	23	,	,	,
cord-022594-fx044gcd	573	24	or	or	CC
cord-022594-fx044gcd	573	25	spectroscopy	spectroscopy	NN
cord-022594-fx044gcd	573	26	is	be	VBZ
cord-022594-fx044gcd	573	27	an	an	DT
cord-022594-fx044gcd	573	28	early	early	JJ
cord-022594-fx044gcd	573	29	feature	feature	NN
cord-022594-fx044gcd	573	30	of	of	IN
cord-022594-fx044gcd	573	31	MS	MS	NNP
cord-022594-fx044gcd	573	32	,	,	,
cord-022594-fx044gcd	573	33	whereas	whereas	IN
cord-022594-fx044gcd	573	34	it	-PRON-	PRP
cord-022594-fx044gcd	573	35	likely	likely	RB
cord-022594-fx044gcd	573	36	does	do	VBZ
cord-022594-fx044gcd	573	37	not	not	RB
cord-022594-fx044gcd	573	38	occur	occur	VB
cord-022594-fx044gcd	573	39	in	in	IN
cord-022594-fx044gcd	573	40	other	other	JJ
cord-022594-fx044gcd	573	41	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	573	42	conditions	condition	NNS
cord-022594-fx044gcd	573	43	such	such	JJ
cord-022594-fx044gcd	573	44	as	as	IN
cord-022594-fx044gcd	573	45	acute	acute	JJ
cord-022594-fx044gcd	573	46	disseminated	disseminate	VBN
cord-022594-fx044gcd	573	47	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	573	48	and	and	CC
cord-022594-fx044gcd	573	49	NMO	NMO	NNP
cord-022594-fx044gcd	573	50	.	.	.
cord-022594-fx044gcd	574	1	Important	important	JJ
cord-022594-fx044gcd	574	2	changes	change	NNS
cord-022594-fx044gcd	574	3	have	have	VBP
cord-022594-fx044gcd	574	4	been	be	VBN
cord-022594-fx044gcd	574	5	made	make	VBN
cord-022594-fx044gcd	574	6	to	to	IN
cord-022594-fx044gcd	574	7	the	the	DT
cord-022594-fx044gcd	574	8	original	original	JJ
cord-022594-fx044gcd	574	9	definition	definition	NN
cord-022594-fx044gcd	574	10	of	of	IN
cord-022594-fx044gcd	574	11	"	"	``
cord-022594-fx044gcd	574	12	dissemination	dissemination	NN
cord-022594-fx044gcd	574	13	in	in	IN
cord-022594-fx044gcd	574	14	time	time	NN
cord-022594-fx044gcd	574	15	"	"	''
cord-022594-fx044gcd	574	16	by	by	IN
cord-022594-fx044gcd	574	17	MRI	MRI	NNP
cord-022594-fx044gcd	574	18	.	.	.
cord-022594-fx044gcd	575	1	In	in	IN
cord-022594-fx044gcd	575	2	keeping	keep	VBG
cord-022594-fx044gcd	575	3	with	with	IN
cord-022594-fx044gcd	575	4	the	the	DT
cord-022594-fx044gcd	575	5	definition	definition	NN
cord-022594-fx044gcd	575	6	that	that	IN
cord-022594-fx044gcd	575	7	clinical	clinical	JJ
cord-022594-fx044gcd	575	8	relapses	relapse	NNS
cord-022594-fx044gcd	575	9	must	must	MD
cord-022594-fx044gcd	575	10	be	be	VB
cord-022594-fx044gcd	575	11	separated	separate	VBN
cord-022594-fx044gcd	575	12	by	by	IN
cord-022594-fx044gcd	575	13	at	at	RB
cord-022594-fx044gcd	575	14	least	least	RBS
cord-022594-fx044gcd	575	15	1	1	CD
cord-022594-fx044gcd	575	16	month	month	NN
cord-022594-fx044gcd	575	17	,	,	,
cord-022594-fx044gcd	575	18	it	-PRON-	PRP
cord-022594-fx044gcd	575	19	was	be	VBD
cord-022594-fx044gcd	575	20	agreed	agree	VBN
cord-022594-fx044gcd	575	21	that	that	IN
cord-022594-fx044gcd	575	22	new	new	JJ
cord-022594-fx044gcd	575	23	T2	T2	NNP
cord-022594-fx044gcd	575	24	lesions	lesion	NNS
cord-022594-fx044gcd	575	25	on	on	IN
cord-022594-fx044gcd	575	26	MRI	MRI	NNP
cord-022594-fx044gcd	575	27	should	should	MD
cord-022594-fx044gcd	575	28	occur	occur	VB
cord-022594-fx044gcd	575	29	at	at	RB
cord-022594-fx044gcd	575	30	least	least	RBS
cord-022594-fx044gcd	575	31	30	30	CD
cord-022594-fx044gcd	575	32	days	day	NNS
cord-022594-fx044gcd	575	33	after	after	IN
cord-022594-fx044gcd	575	34	disease	disease	NN
cord-022594-fx044gcd	575	35	onset	onset	NN
cord-022594-fx044gcd	575	36	.	.	.
cord-022594-fx044gcd	576	1	This	this	DT
cord-022594-fx044gcd	576	2	means	mean	VBZ
cord-022594-fx044gcd	576	3	that	that	IN
cord-022594-fx044gcd	576	4	any	any	DT
cord-022594-fx044gcd	576	5	new	new	JJ
cord-022594-fx044gcd	576	6	T2	T2	NNP
cord-022594-fx044gcd	576	7	lesion	lesion	NN
cord-022594-fx044gcd	576	8	occurring	occur	VBG
cord-022594-fx044gcd	576	9	at	at	IN
cord-022594-fx044gcd	576	10	any	any	DT
cord-022594-fx044gcd	576	11	time	time	NN
cord-022594-fx044gcd	576	12	point	point	NN
cord-022594-fx044gcd	576	13	after	after	IN
cord-022594-fx044gcd	576	14	a	a	DT
cord-022594-fx044gcd	576	15	so	so	RB
cord-022594-fx044gcd	576	16	-	-	HYPH
cord-022594-fx044gcd	576	17	called	call	VBN
cord-022594-fx044gcd	576	18	reference	reference	NN
cord-022594-fx044gcd	576	19	scan	scan	NN
cord-022594-fx044gcd	576	20	performed	perform	VBN
cord-022594-fx044gcd	576	21	at	at	IN
cord-022594-fx044gcd	576	22	least	least	RBS
cord-022594-fx044gcd	576	23	30	30	CD
cord-022594-fx044gcd	576	24	days	day	NNS
cord-022594-fx044gcd	576	25	after	after	IN
cord-022594-fx044gcd	576	26	the	the	DT
cord-022594-fx044gcd	576	27	onset	onset	NN
cord-022594-fx044gcd	576	28	of	of	IN
cord-022594-fx044gcd	576	29	the	the	DT
cord-022594-fx044gcd	576	30	initial	initial	JJ
cord-022594-fx044gcd	576	31	clinical	clinical	JJ
cord-022594-fx044gcd	576	32	event	event	NN
cord-022594-fx044gcd	576	33	is	be	VBZ
cord-022594-fx044gcd	576	34	useful	useful	JJ
cord-022594-fx044gcd	576	35	in	in	IN
cord-022594-fx044gcd	576	36	meeting	meeting	NN
cord-022594-fx044gcd	576	37	imaging	image	VBG
cord-022594-fx044gcd	576	38	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	576	39	criteria	criterion	NNS
cord-022594-fx044gcd	576	40	for	for	IN
cord-022594-fx044gcd	576	41	dissemination	dissemination	NN
cord-022594-fx044gcd	576	42	in	in	IN
cord-022594-fx044gcd	576	43	time	time	NN
cord-022594-fx044gcd	576	44	.	.	.
cord-022594-fx044gcd	577	1	It	-PRON-	PRP
cord-022594-fx044gcd	577	2	should	should	MD
cord-022594-fx044gcd	577	3	be	be	VB
cord-022594-fx044gcd	577	4	noted	note	VBN
cord-022594-fx044gcd	577	5	though	though	IN
cord-022594-fx044gcd	577	6	that	that	IN
cord-022594-fx044gcd	577	7	a	a	DT
cord-022594-fx044gcd	577	8	new	new	JJ
cord-022594-fx044gcd	577	9	T2	T2	NNP
cord-022594-fx044gcd	577	10	lesion	lesion	NN
cord-022594-fx044gcd	577	11	must	must	MD
cord-022594-fx044gcd	577	12	be	be	VB
cord-022594-fx044gcd	577	13	of	of	IN
cord-022594-fx044gcd	577	14	sufficient	sufficient	JJ
cord-022594-fx044gcd	577	15	size	size	NN
cord-022594-fx044gcd	577	16	and	and	CC
cord-022594-fx044gcd	577	17	location	location	NN
cord-022594-fx044gcd	577	18	to	to	TO
cord-022594-fx044gcd	577	19	exclude	exclude	VB
cord-022594-fx044gcd	577	20	lesions	lesion	NNS
cord-022594-fx044gcd	577	21	that	that	WDT
cord-022594-fx044gcd	577	22	could	could	MD
cord-022594-fx044gcd	577	23	have	have	VB
cord-022594-fx044gcd	577	24	been	be	VBN
cord-022594-fx044gcd	577	25	missed	miss	VBN
cord-022594-fx044gcd	577	26	previously	previously	RB
cord-022594-fx044gcd	577	27	for	for	IN
cord-022594-fx044gcd	577	28	technical	technical	JJ
cord-022594-fx044gcd	577	29	reasons	reason	NNS
cord-022594-fx044gcd	577	30	of	of	IN
cord-022594-fx044gcd	577	31	slice	slice	NN
cord-022594-fx044gcd	577	32	orientation	orientation	NN
cord-022594-fx044gcd	577	33	,	,	,
cord-022594-fx044gcd	577	34	thickness	thickness	NN
cord-022594-fx044gcd	577	35	or	or	CC
cord-022594-fx044gcd	577	36	spacing	spacing	NN
cord-022594-fx044gcd	577	37	,	,	,
cord-022594-fx044gcd	577	38	tissue	tissue	NN
cord-022594-fx044gcd	577	39	contrast	contrast	NN
cord-022594-fx044gcd	577	40	,	,	,
cord-022594-fx044gcd	577	41	patient	patient	JJ
cord-022594-fx044gcd	577	42	motion	motion	NN
cord-022594-fx044gcd	577	43	,	,	,
cord-022594-fx044gcd	577	44	or	or	CC
cord-022594-fx044gcd	577	45	other	other	JJ
cord-022594-fx044gcd	577	46	artifacts	artifact	NNS
cord-022594-fx044gcd	577	47	.	.	.
cord-022594-fx044gcd	578	1	This	this	DT
cord-022594-fx044gcd	578	2	requires	require	VBZ
cord-022594-fx044gcd	578	3	standardized	standardized	JJ
cord-022594-fx044gcd	578	4	scanning	scanning	NN
cord-022594-fx044gcd	578	5	procedures	procedure	NNS
cord-022594-fx044gcd	578	6	with	with	IN
cord-022594-fx044gcd	578	7	emphasis	emphasis	NN
cord-022594-fx044gcd	578	8	on	on	IN
cord-022594-fx044gcd	578	9	careful	careful	JJ
cord-022594-fx044gcd	578	10	repositioning	repositioning	NN
cord-022594-fx044gcd	578	11	,	,	,
cord-022594-fx044gcd	578	12	as	as	RB
cord-022594-fx044gcd	578	13	well	well	RB
cord-022594-fx044gcd	578	14	as	as	IN
cord-022594-fx044gcd	578	15	input	input	NN
cord-022594-fx044gcd	578	16	from	from	IN
cord-022594-fx044gcd	578	17	qualified	qualified	JJ
cord-022594-fx044gcd	578	18	evaluators	evaluator	NNS
cord-022594-fx044gcd	578	19	experienced	experience	VBN
cord-022594-fx044gcd	578	20	in	in	IN
cord-022594-fx044gcd	578	21	MS	MS	NNP
cord-022594-fx044gcd	578	22	imaging	imaging	NN
cord-022594-fx044gcd	578	23	.	.	.
cord-022594-fx044gcd	579	1	With	with	IN
cord-022594-fx044gcd	579	2	the	the	DT
cord-022594-fx044gcd	579	3	new	new	JJ
cord-022594-fx044gcd	579	4	revision	revision	NN
cord-022594-fx044gcd	579	5	,	,	,
cord-022594-fx044gcd	579	6	there	there	EX
cord-022594-fx044gcd	579	7	are	be	VBP
cord-022594-fx044gcd	579	8	two	two	CD
cord-022594-fx044gcd	579	9	ways	way	NNS
cord-022594-fx044gcd	579	10	to	to	TO
cord-022594-fx044gcd	579	11	show	show	VB
cord-022594-fx044gcd	579	12	dissemination	dissemination	NN
cord-022594-fx044gcd	579	13	in	in	IN
cord-022594-fx044gcd	579	14	time	time	NN
cord-022594-fx044gcd	579	15	using	use	VBG
cord-022594-fx044gcd	579	16	imaging	image	VBG
cord-022594-fx044gcd	579	17	:	:	:
cord-022594-fx044gcd	579	18	(	(	-LRB-
cord-022594-fx044gcd	579	19	1	1	LS
cord-022594-fx044gcd	579	20	)	)	-RRB-
cord-022594-fx044gcd	579	21	detection	detection	NN
cord-022594-fx044gcd	579	22	of	of	IN
cord-022594-fx044gcd	579	23	gadolinium	gadolinium	NN
cord-022594-fx044gcd	579	24	enhancement	enhancement	NN
cord-022594-fx044gcd	579	25	at	at	IN
cord-022594-fx044gcd	579	26	least	least	JJS
cord-022594-fx044gcd	579	27	3	3	CD
cord-022594-fx044gcd	579	28	months	month	NNS
cord-022594-fx044gcd	579	29	after	after	IN
cord-022594-fx044gcd	579	30	the	the	DT
cord-022594-fx044gcd	579	31	onset	onset	NN
cord-022594-fx044gcd	579	32	of	of	IN
cord-022594-fx044gcd	579	33	initial	initial	JJ
cord-022594-fx044gcd	579	34	clinical	clinical	JJ
cord-022594-fx044gcd	579	35	event	event	NN
cord-022594-fx044gcd	579	36	,	,	,
cord-022594-fx044gcd	579	37	if	if	IN
cord-022594-fx044gcd	579	38	not	not	RB
cord-022594-fx044gcd	579	39	at	at	IN
cord-022594-fx044gcd	579	40	the	the	DT
cord-022594-fx044gcd	579	41	site	site	NN
cord-022594-fx044gcd	579	42	corresponding	correspond	VBG
cord-022594-fx044gcd	579	43	to	to	IN
cord-022594-fx044gcd	579	44	the	the	DT
cord-022594-fx044gcd	579	45	initial	initial	JJ
cord-022594-fx044gcd	579	46	event	event	NN
cord-022594-fx044gcd	579	47	;	;	:
cord-022594-fx044gcd	579	48	or	or	CC
cord-022594-fx044gcd	579	49	(	(	-LRB-
cord-022594-fx044gcd	579	50	2	2	LS
cord-022594-fx044gcd	579	51	)	)	-RRB-
cord-022594-fx044gcd	579	52	detection	detection	NN
cord-022594-fx044gcd	579	53	of	of	IN
cord-022594-fx044gcd	579	54	a	a	DT
cord-022594-fx044gcd	579	55	new	new	JJ
cord-022594-fx044gcd	579	56	T2	T2	NNP
cord-022594-fx044gcd	579	57	lesion	lesion	NN
cord-022594-fx044gcd	579	58	if	if	IN
cord-022594-fx044gcd	579	59	this	this	DT
cord-022594-fx044gcd	579	60	appears	appear	VBZ
cord-022594-fx044gcd	579	61	at	at	IN
cord-022594-fx044gcd	579	62	any	any	DT
cord-022594-fx044gcd	579	63	time	time	NN
cord-022594-fx044gcd	579	64	compared	compare	VBN
cord-022594-fx044gcd	579	65	with	with	IN
cord-022594-fx044gcd	579	66	a	a	DT
cord-022594-fx044gcd	579	67	reference	reference	NN
cord-022594-fx044gcd	579	68	scan	scan	NN
cord-022594-fx044gcd	579	69	done	do	VBN
cord-022594-fx044gcd	579	70	at	at	RB
cord-022594-fx044gcd	579	71	least	least	RBS
cord-022594-fx044gcd	579	72	30	30	CD
cord-022594-fx044gcd	579	73	days	day	NNS
cord-022594-fx044gcd	579	74	after	after	IN
cord-022594-fx044gcd	579	75	onset	onset	NN
cord-022594-fx044gcd	579	76	of	of	IN
cord-022594-fx044gcd	579	77	the	the	DT
cord-022594-fx044gcd	579	78	initial	initial	JJ
cord-022594-fx044gcd	579	79	clinical	clinical	JJ
cord-022594-fx044gcd	579	80	event	event	NN
cord-022594-fx044gcd	579	81	.	.	.
cord-022594-fx044gcd	580	1	Spinal	spinal	JJ
cord-022594-fx044gcd	580	2	cord	cord	NN
cord-022594-fx044gcd	580	3	lesions	lesion	NNS
cord-022594-fx044gcd	580	4	can	can	MD
cord-022594-fx044gcd	580	5	be	be	VB
cord-022594-fx044gcd	580	6	important	important	JJ
cord-022594-fx044gcd	580	7	in	in	IN
cord-022594-fx044gcd	580	8	differentiating	differentiate	VBG
cord-022594-fx044gcd	580	9	MS	MS	NNP
cord-022594-fx044gcd	580	10	from	from	IN
cord-022594-fx044gcd	580	11	other	other	JJ
cord-022594-fx044gcd	580	12	white	white	JJ
cord-022594-fx044gcd	580	13	matter	matter	NN
cord-022594-fx044gcd	580	14	diseases	disease	NNS
cord-022594-fx044gcd	580	15	;	;	:
cord-022594-fx044gcd	580	16	however	however	RB
cord-022594-fx044gcd	580	17	,	,	,
cord-022594-fx044gcd	580	18	the	the	DT
cord-022594-fx044gcd	580	19	original	original	JJ
cord-022594-fx044gcd	580	20	McDonald	McDonald	NNP
cord-022594-fx044gcd	580	21	Criteria	Criteria	NNP
cord-022594-fx044gcd	580	22	did	do	VBD
cord-022594-fx044gcd	580	23	not	not	RB
cord-022594-fx044gcd	580	24	provide	provide	VB
cord-022594-fx044gcd	580	25	sufficient	sufficient	JJ
cord-022594-fx044gcd	580	26	guidelines	guideline	NNS
cord-022594-fx044gcd	580	27	for	for	IN
cord-022594-fx044gcd	580	28	the	the	DT
cord-022594-fx044gcd	580	29	use	use	NN
cord-022594-fx044gcd	580	30	of	of	IN
cord-022594-fx044gcd	580	31	cord	cord	NN
cord-022594-fx044gcd	580	32	imaging	imaging	NN
cord-022594-fx044gcd	580	33	in	in	IN
cord-022594-fx044gcd	580	34	MS	MS	NNP
cord-022594-fx044gcd	580	35	.	.	.
cord-022594-fx044gcd	581	1	Spinal	spinal	JJ
cord-022594-fx044gcd	581	2	cord	cord	NN
cord-022594-fx044gcd	581	3	imaging	imaging	NN
cord-022594-fx044gcd	581	4	that	that	WDT
cord-022594-fx044gcd	581	5	detects	detect	VBZ
cord-022594-fx044gcd	581	6	typical	typical	JJ
cord-022594-fx044gcd	581	7	MS	MS	NNP
cord-022594-fx044gcd	581	8	cord	cord	NN
cord-022594-fx044gcd	581	9	lesions	lesion	NNS
cord-022594-fx044gcd	581	10	(	(	-LRB-
cord-022594-fx044gcd	581	11	minimal	minimal	JJ
cord-022594-fx044gcd	581	12	or	or	CC
cord-022594-fx044gcd	581	13	no	no	DT
cord-022594-fx044gcd	581	14	swelling	swelling	NN
cord-022594-fx044gcd	581	15	of	of	IN
cord-022594-fx044gcd	581	16	the	the	DT
cord-022594-fx044gcd	581	17	cord	cord	NN
cord-022594-fx044gcd	581	18	;	;	.
cord-022594-fx044gcd	582	1	clearly	clearly	RB
cord-022594-fx044gcd	582	2	hyperintense	hyperintense	NNP
cord-022594-fx044gcd	582	3	on	on	IN
cord-022594-fx044gcd	582	4	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	582	5	imaging	imaging	NN
cord-022594-fx044gcd	582	6	;	;	:
cord-022594-fx044gcd	582	7	at	at	RB
cord-022594-fx044gcd	582	8	least	least	JJS
cord-022594-fx044gcd	582	9	3	3	CD
cord-022594-fx044gcd	582	10	mm	mm	NN
cord-022594-fx044gcd	582	11	in	in	IN
cord-022594-fx044gcd	582	12	size	size	NN
cord-022594-fx044gcd	582	13	,	,	,
cord-022594-fx044gcd	582	14	but	but	CC
cord-022594-fx044gcd	582	15	less	less	JJR
cord-022594-fx044gcd	582	16	than	than	IN
cord-022594-fx044gcd	582	17	two	two	CD
cord-022594-fx044gcd	582	18	vertebral	vertebral	JJ
cord-022594-fx044gcd	582	19	segments	segment	NNS
cord-022594-fx044gcd	582	20	long	long	RB
cord-022594-fx044gcd	582	21	;	;	:
cord-022594-fx044gcd	582	22	and	and	CC
cord-022594-fx044gcd	582	23	occupying	occupy	VBG
cord-022594-fx044gcd	582	24	only	only	RB
cord-022594-fx044gcd	582	25	part	part	NN
cord-022594-fx044gcd	582	26	of	of	IN
cord-022594-fx044gcd	582	27	the	the	DT
cord-022594-fx044gcd	582	28	cord	cord	NN
cord-022594-fx044gcd	582	29	cross	cross	NN
cord-022594-fx044gcd	582	30	section	section	NN
cord-022594-fx044gcd	582	31	)	)	-RRB-
cord-022594-fx044gcd	582	32	is	be	VBZ
cord-022594-fx044gcd	582	33	particularly	particularly	RB
cord-022594-fx044gcd	582	34	helpful	helpful	JJ
cord-022594-fx044gcd	582	35	if	if	IN
cord-022594-fx044gcd	582	36	brain	brain	NN
cord-022594-fx044gcd	582	37	imaging	imaging	NN
cord-022594-fx044gcd	582	38	does	do	VBZ
cord-022594-fx044gcd	582	39	not	not	RB
cord-022594-fx044gcd	582	40	detect	detect	VB
cord-022594-fx044gcd	582	41	dissemination	dissemination	NN
cord-022594-fx044gcd	582	42	in	in	IN
cord-022594-fx044gcd	582	43	space	space	NN
cord-022594-fx044gcd	582	44	in	in	IN
cord-022594-fx044gcd	582	45	a	a	DT
cord-022594-fx044gcd	582	46	patient	patient	NN
cord-022594-fx044gcd	582	47	suspected	suspect	VBN
cord-022594-fx044gcd	582	48	to	to	TO
cord-022594-fx044gcd	582	49	have	have	VB
cord-022594-fx044gcd	582	50	MS	MS	NNP
cord-022594-fx044gcd	582	51	.	.	.
cord-022594-fx044gcd	583	1	For	for	IN
cord-022594-fx044gcd	583	2	dissemination	dissemination	NN
cord-022594-fx044gcd	583	3	in	in	IN
cord-022594-fx044gcd	583	4	space	space	NN
cord-022594-fx044gcd	583	5	,	,	,
cord-022594-fx044gcd	583	6	a	a	DT
cord-022594-fx044gcd	583	7	spinal	spinal	JJ
cord-022594-fx044gcd	583	8	cord	cord	NN
cord-022594-fx044gcd	583	9	lesion	lesion	NN
cord-022594-fx044gcd	583	10	is	be	VBZ
cord-022594-fx044gcd	583	11	equivalent	equivalent	JJ
cord-022594-fx044gcd	583	12	to	to	IN
cord-022594-fx044gcd	583	13	,	,	,
cord-022594-fx044gcd	583	14	and	and	CC
cord-022594-fx044gcd	583	15	can	can	MD
cord-022594-fx044gcd	583	16	substitute	substitute	VB
cord-022594-fx044gcd	583	17	for	for	IN
cord-022594-fx044gcd	583	18	,	,	,
cord-022594-fx044gcd	583	19	a	a	DT
cord-022594-fx044gcd	583	20	brain	brain	NN
cord-022594-fx044gcd	583	21	infratentorial	infratentorial	JJ
cord-022594-fx044gcd	583	22	lesion	lesion	NN
cord-022594-fx044gcd	583	23	,	,	,
cord-022594-fx044gcd	583	24	but	but	CC
cord-022594-fx044gcd	583	25	not	not	RB
cord-022594-fx044gcd	583	26	for	for	IN
cord-022594-fx044gcd	583	27	a	a	DT
cord-022594-fx044gcd	583	28	periventricular	periventricular	JJ
cord-022594-fx044gcd	583	29	or	or	CC
cord-022594-fx044gcd	583	30	juxtacortical	juxtacortical	JJ
cord-022594-fx044gcd	583	31	lesion	lesion	NN
cord-022594-fx044gcd	583	32	.	.	.
cord-022594-fx044gcd	584	1	An	an	DT
cord-022594-fx044gcd	584	2	enhancing	enhance	VBG
cord-022594-fx044gcd	584	3	spinal	spinal	JJ
cord-022594-fx044gcd	584	4	cord	cord	NN
cord-022594-fx044gcd	584	5	lesion	lesion	NN
cord-022594-fx044gcd	584	6	is	be	VBZ
cord-022594-fx044gcd	584	7	equivalent	equivalent	JJ
cord-022594-fx044gcd	584	8	to	to	IN
cord-022594-fx044gcd	584	9	an	an	DT
cord-022594-fx044gcd	584	10	enhancing	enhance	VBG
cord-022594-fx044gcd	584	11	brain	brain	NN
cord-022594-fx044gcd	584	12	lesion	lesion	NN
cord-022594-fx044gcd	584	13	,	,	,
cord-022594-fx044gcd	584	14	and	and	CC
cord-022594-fx044gcd	584	15	an	an	DT
cord-022594-fx044gcd	584	16	enhancing	enhance	VBG
cord-022594-fx044gcd	584	17	spinal	spinal	JJ
cord-022594-fx044gcd	584	18	cord	cord	NN
cord-022594-fx044gcd	584	19	lesion	lesion	NN
cord-022594-fx044gcd	584	20	can	can	MD
cord-022594-fx044gcd	584	21	"	"	``
cord-022594-fx044gcd	584	22	count	count	VB
cord-022594-fx044gcd	584	23	"	"	''
cord-022594-fx044gcd	584	24	doubly	doubly	RB
cord-022594-fx044gcd	584	25	in	in	IN
cord-022594-fx044gcd	584	26	fulfilling	fulfil	VBG
cord-022594-fx044gcd	584	27	the	the	DT
cord-022594-fx044gcd	584	28	criteria	criterion	NNS
cord-022594-fx044gcd	584	29	(	(	-LRB-
cord-022594-fx044gcd	584	30	e.g.	e.g.	RB
cord-022594-fx044gcd	584	31	,	,	,
cord-022594-fx044gcd	584	32	a	a	DT
cord-022594-fx044gcd	584	33	single	single	JJ
cord-022594-fx044gcd	584	34	enhancing	enhance	VBG
cord-022594-fx044gcd	584	35	spinal	spinal	JJ
cord-022594-fx044gcd	584	36	cord	cord	NN
cord-022594-fx044gcd	584	37	lesion	lesion	NN
cord-022594-fx044gcd	584	38	can	can	MD
cord-022594-fx044gcd	584	39	"	"	``
cord-022594-fx044gcd	584	40	count	count	VB
cord-022594-fx044gcd	584	41	"	"	''
cord-022594-fx044gcd	584	42	for	for	IN
cord-022594-fx044gcd	584	43	an	an	DT
cord-022594-fx044gcd	584	44	enhancing	enhance	VBG
cord-022594-fx044gcd	584	45	lesion	lesion	NN
cord-022594-fx044gcd	584	46	and	and	CC
cord-022594-fx044gcd	584	47	an	an	DT
cord-022594-fx044gcd	584	48	infratentorial	infratentorial	JJ
cord-022594-fx044gcd	584	49	lesion	lesion	NN
cord-022594-fx044gcd	584	50	)	)	-RRB-
cord-022594-fx044gcd	584	51	.	.	.
cord-022594-fx044gcd	585	1	Individual	individual	JJ
cord-022594-fx044gcd	585	2	cord	cord	NN
cord-022594-fx044gcd	585	3	lesions	lesion	NNS
cord-022594-fx044gcd	585	4	can	can	MD
cord-022594-fx044gcd	585	5	contribute	contribute	VB
cord-022594-fx044gcd	585	6	together	together	RB
cord-022594-fx044gcd	585	7	with	with	IN
cord-022594-fx044gcd	585	8	individual	individual	JJ
cord-022594-fx044gcd	585	9	brain	brain	NN
cord-022594-fx044gcd	585	10	lesions	lesion	NNS
cord-022594-fx044gcd	585	11	to	to	TO
cord-022594-fx044gcd	585	12	reach	reach	VB
cord-022594-fx044gcd	585	13	the	the	DT
cord-022594-fx044gcd	585	14	required	require	VBN
cord-022594-fx044gcd	585	15	nine	nine	CD
cord-022594-fx044gcd	585	16	T2	T2	NNP
cord-022594-fx044gcd	585	17	lesions	lesion	NNS
cord-022594-fx044gcd	585	18	to	to	TO
cord-022594-fx044gcd	585	19	satisfy	satisfy	VB
cord-022594-fx044gcd	585	20	the	the	DT
cord-022594-fx044gcd	585	21	Barkhof	Barkhof	NNP
cord-022594-fx044gcd	585	22	-	-	HYPH
cord-022594-fx044gcd	585	23	Tintore	Tintore	NNP
cord-022594-fx044gcd	585	24	criteria	criterion	NNS
cord-022594-fx044gcd	586	1	(	(	-LRB-
cord-022594-fx044gcd	586	2	the	the	DT
cord-022594-fx044gcd	586	3	MRI	MRI	NNP
cord-022594-fx044gcd	586	4	criteria	criterion	NNS
cord-022594-fx044gcd	586	5	incorporated	incorporate	VBN
cord-022594-fx044gcd	586	6	in	in	IN
cord-022594-fx044gcd	586	7	the	the	DT
cord-022594-fx044gcd	586	8	original	original	JJ
cord-022594-fx044gcd	586	9	McDonald	McDonald	NNP
cord-022594-fx044gcd	586	10	's	's	POS
cord-022594-fx044gcd	586	11	criteria	criterion	NNS
cord-022594-fx044gcd	586	12	)	)	-RRB-
cord-022594-fx044gcd	586	13	.	.	.
cord-022594-fx044gcd	587	1	The	the	DT
cord-022594-fx044gcd	587	2	panel	panel	NN
cord-022594-fx044gcd	587	3	recognized	recognize	VBD
cord-022594-fx044gcd	587	4	that	that	IN
cord-022594-fx044gcd	587	5	diffuse	diffuse	JJ
cord-022594-fx044gcd	587	6	cord	cord	NN
cord-022594-fx044gcd	587	7	changes	change	NNS
cord-022594-fx044gcd	587	8	may	may	MD
cord-022594-fx044gcd	587	9	occur	occur	VB
cord-022594-fx044gcd	587	10	in	in	IN
cord-022594-fx044gcd	587	11	MS	MS	NNP
cord-022594-fx044gcd	587	12	,	,	,
cord-022594-fx044gcd	587	13	especially	especially	RB
cord-022594-fx044gcd	587	14	in	in	IN
cord-022594-fx044gcd	587	15	the	the	DT
cord-022594-fx044gcd	587	16	progressive	progressive	JJ
cord-022594-fx044gcd	587	17	forms	form	NNS
cord-022594-fx044gcd	587	18	;	;	:
cord-022594-fx044gcd	587	19	however	however	RB
cord-022594-fx044gcd	587	20	,	,	,
cord-022594-fx044gcd	587	21	these	these	DT
cord-022594-fx044gcd	587	22	changes	change	NNS
cord-022594-fx044gcd	587	23	are	be	VBP
cord-022594-fx044gcd	587	24	not	not	RB
cord-022594-fx044gcd	587	25	sufficiently	sufficiently	RB
cord-022594-fx044gcd	587	26	reliable	reliable	JJ
cord-022594-fx044gcd	587	27	to	to	TO
cord-022594-fx044gcd	587	28	allow	allow	VB
cord-022594-fx044gcd	587	29	for	for	IN
cord-022594-fx044gcd	587	30	their	-PRON-	PRP$
cord-022594-fx044gcd	587	31	incorporation	incorporation	NN
cord-022594-fx044gcd	587	32	into	into	IN
cord-022594-fx044gcd	587	33	the	the	DT
cord-022594-fx044gcd	587	34	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	587	35	criteria	criterion	NNS
cord-022594-fx044gcd	587	36	at	at	IN
cord-022594-fx044gcd	587	37	this	this	DT
cord-022594-fx044gcd	587	38	time	time	NN
cord-022594-fx044gcd	587	39	.	.	.
cord-022594-fx044gcd	588	1	Repeat	repeat	VB
cord-022594-fx044gcd	588	2	spinal	spinal	JJ
cord-022594-fx044gcd	588	3	cord	cord	NN
cord-022594-fx044gcd	588	4	imaging	imaging	NN
cord-022594-fx044gcd	588	5	in	in	IN
cord-022594-fx044gcd	588	6	patients	patient	NNS
cord-022594-fx044gcd	588	7	without	without	IN
cord-022594-fx044gcd	588	8	new	new	JJ
cord-022594-fx044gcd	588	9	symptoms	symptom	NNS
cord-022594-fx044gcd	588	10	of	of	IN
cord-022594-fx044gcd	588	11	myelitis	myelitis	NNP
cord-022594-fx044gcd	588	12	has	have	VBZ
cord-022594-fx044gcd	588	13	a	a	DT
cord-022594-fx044gcd	588	14	low	low	JJ
cord-022594-fx044gcd	588	15	yield	yield	NN
cord-022594-fx044gcd	588	16	in	in	IN
cord-022594-fx044gcd	588	17	efforts	effort	NNS
cord-022594-fx044gcd	588	18	to	to	TO
cord-022594-fx044gcd	588	19	demonstrate	demonstrate	VB
cord-022594-fx044gcd	588	20	dissemination	dissemination	NN
cord-022594-fx044gcd	588	21	of	of	IN
cord-022594-fx044gcd	588	22	lesions	lesion	NNS
cord-022594-fx044gcd	588	23	in	in	IN
cord-022594-fx044gcd	588	24	time	time	NN
cord-022594-fx044gcd	588	25	.	.	.
cord-022594-fx044gcd	589	1	In	in	IN
cord-022594-fx044gcd	589	2	other	other	JJ
cord-022594-fx044gcd	589	3	words	word	NNS
cord-022594-fx044gcd	589	4	,	,	,
cord-022594-fx044gcd	589	5	while	while	IN
cord-022594-fx044gcd	589	6	it	-PRON-	PRP
cord-022594-fx044gcd	589	7	is	be	VBZ
cord-022594-fx044gcd	589	8	common	common	JJ
cord-022594-fx044gcd	589	9	to	to	TO
cord-022594-fx044gcd	589	10	see	see	VB
cord-022594-fx044gcd	589	11	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	589	12	new	new	JJ
cord-022594-fx044gcd	589	13	brain	brain	NN
cord-022594-fx044gcd	589	14	lesions	lesion	NNS
cord-022594-fx044gcd	589	15	on	on	IN
cord-022594-fx044gcd	589	16	repeated	repeat	VBN
cord-022594-fx044gcd	589	17	scans	scan	NNS
cord-022594-fx044gcd	589	18	,	,	,
cord-022594-fx044gcd	589	19	new	new	JJ
cord-022594-fx044gcd	589	20	cord	cord	NN
cord-022594-fx044gcd	589	21	lesions	lesion	NNS
cord-022594-fx044gcd	589	22	generally	generally	RB
cord-022594-fx044gcd	589	23	do	do	VBP
cord-022594-fx044gcd	589	24	result	result	VB
cord-022594-fx044gcd	589	25	in	in	IN
cord-022594-fx044gcd	589	26	new	new	JJ
cord-022594-fx044gcd	589	27	neurological	neurological	JJ
cord-022594-fx044gcd	589	28	symptoms	symptom	NNS
cord-022594-fx044gcd	589	29	.	.	.
cord-022594-fx044gcd	590	1	Therefore	therefore	RB
cord-022594-fx044gcd	590	2	,	,	,
cord-022594-fx044gcd	590	3	repeat	repeat	VB
cord-022594-fx044gcd	590	4	cord	cord	NN
cord-022594-fx044gcd	590	5	imaging	imaging	NN
cord-022594-fx044gcd	590	6	is	be	VBZ
cord-022594-fx044gcd	590	7	recommended	recommend	VBN
cord-022594-fx044gcd	590	8	only	only	RB
cord-022594-fx044gcd	590	9	to	to	TO
cord-022594-fx044gcd	590	10	support	support	VB
cord-022594-fx044gcd	590	11	an	an	DT
cord-022594-fx044gcd	590	12	MS	MS	NNP
cord-022594-fx044gcd	590	13	diagnosis	diagnosis	NN
cord-022594-fx044gcd	590	14	when	when	WRB
cord-022594-fx044gcd	590	15	there	there	EX
cord-022594-fx044gcd	590	16	is	be	VBZ
cord-022594-fx044gcd	590	17	a	a	DT
cord-022594-fx044gcd	590	18	clinical	clinical	JJ
cord-022594-fx044gcd	590	19	reason	reason	NN
cord-022594-fx044gcd	590	20	to	to	TO
cord-022594-fx044gcd	590	21	suspect	suspect	VB
cord-022594-fx044gcd	590	22	a	a	DT
cord-022594-fx044gcd	590	23	new	new	JJ
cord-022594-fx044gcd	590	24	cord	cord	NN
cord-022594-fx044gcd	590	25	lesion	lesion	NN
cord-022594-fx044gcd	590	26	.	.	.
cord-022594-fx044gcd	591	1	Important	important	JJ
cord-022594-fx044gcd	591	2	changes	change	NNS
cord-022594-fx044gcd	591	3	have	have	VBP
cord-022594-fx044gcd	591	4	been	be	VBN
cord-022594-fx044gcd	591	5	proposed	propose	VBN
cord-022594-fx044gcd	591	6	in	in	IN
cord-022594-fx044gcd	591	7	diagnosing	diagnose	VBG
cord-022594-fx044gcd	591	8	primary	primary	JJ
cord-022594-fx044gcd	591	9	progressive	progressive	JJ
cord-022594-fx044gcd	591	10	MS	MS	NNP
cord-022594-fx044gcd	591	11	.	.	.
cord-022594-fx044gcd	592	1	These	these	DT
cord-022594-fx044gcd	592	2	Revised	revise	VBN
cord-022594-fx044gcd	592	3	Criteria	Criteria	NNP
cord-022594-fx044gcd	592	4	stress	stress	VBP
cord-022594-fx044gcd	592	5	clinical	clinical	JJ
cord-022594-fx044gcd	592	6	and	and	CC
cord-022594-fx044gcd	592	7	imaging	image	VBG
cord-022594-fx044gcd	592	8	(	(	-LRB-
cord-022594-fx044gcd	592	9	brain	brain	NN
cord-022594-fx044gcd	592	10	or	or	CC
cord-022594-fx044gcd	592	11	spinal	spinal	JJ
cord-022594-fx044gcd	592	12	cord	cord	NN
cord-022594-fx044gcd	592	13	)	)	-RRB-
cord-022594-fx044gcd	592	14	evidence	evidence	NN
cord-022594-fx044gcd	592	15	for	for	IN
cord-022594-fx044gcd	592	16	diagnosis	diagnosis	NN
cord-022594-fx044gcd	592	17	and	and	CC
cord-022594-fx044gcd	592	18	place	place	NN
cord-022594-fx044gcd	592	19	less	less	JJR
cord-022594-fx044gcd	592	20	emphasis	emphasis	NN
cord-022594-fx044gcd	592	21	on	on	IN
cord-022594-fx044gcd	592	22	CSF	CSF	NNP
cord-022594-fx044gcd	592	23	findings	finding	NNS
cord-022594-fx044gcd	592	24	.	.	.
cord-022594-fx044gcd	593	1	The	the	DT
cord-022594-fx044gcd	593	2	new	new	JJ
cord-022594-fx044gcd	593	3	criteria	criterion	NNS
cord-022594-fx044gcd	593	4	for	for	IN
cord-022594-fx044gcd	593	5	PPMS	PPMS	NNP
cord-022594-fx044gcd	593	6	is	be	VBZ
cord-022594-fx044gcd	593	7	as	as	IN
cord-022594-fx044gcd	593	8	follows	follow	VBZ
cord-022594-fx044gcd	593	9	:	:	:
cord-022594-fx044gcd	594	1	(	(	-LRB-
cord-022594-fx044gcd	594	2	1	1	LS
cord-022594-fx044gcd	594	3	)	)	-RRB-
cord-022594-fx044gcd	594	4	at	at	IN
cord-022594-fx044gcd	594	5	least	least	JJS
cord-022594-fx044gcd	594	6	1	1	CD
cord-022594-fx044gcd	594	7	year	year	NN
cord-022594-fx044gcd	594	8	of	of	IN
cord-022594-fx044gcd	594	9	disease	disease	NN
cord-022594-fx044gcd	594	10	progression	progression	NN
cord-022594-fx044gcd	594	11	(	(	-LRB-
cord-022594-fx044gcd	594	12	retrospectively	retrospectively	RB
cord-022594-fx044gcd	594	13	or	or	CC
cord-022594-fx044gcd	594	14	prospectively	prospectively	RB
cord-022594-fx044gcd	594	15	determined	determine	VBN
cord-022594-fx044gcd	594	16	)	)	-RRB-
cord-022594-fx044gcd	594	17	(	(	-LRB-
cord-022594-fx044gcd	594	18	2	2	LS
cord-022594-fx044gcd	594	19	)	)	-RRB-
cord-022594-fx044gcd	594	20	plus	plus	CC
cord-022594-fx044gcd	594	21	two	two	CD
cord-022594-fx044gcd	594	22	of	of	IN
cord-022594-fx044gcd	594	23	the	the	DT
cord-022594-fx044gcd	594	24	following	follow	VBG
cord-022594-fx044gcd	594	25	:	:	:
cord-022594-fx044gcd	594	26	(	(	-LRB-
cord-022594-fx044gcd	594	27	a	a	DT
cord-022594-fx044gcd	594	28	)	)	-RRB-
cord-022594-fx044gcd	594	29	positive	positive	JJ
cord-022594-fx044gcd	594	30	brain	brain	NN
cord-022594-fx044gcd	594	31	MRI	MRI	NNP
cord-022594-fx044gcd	594	32	(	(	-LRB-
cord-022594-fx044gcd	594	33	nine	nine	CD
cord-022594-fx044gcd	594	34	T2	T2	NNP
cord-022594-fx044gcd	594	35	lesions	lesion	NNS
cord-022594-fx044gcd	594	36	or	or	CC
cord-022594-fx044gcd	594	37	four	four	CD
cord-022594-fx044gcd	594	38	or	or	CC
cord-022594-fx044gcd	594	39	more	more	JJR
cord-022594-fx044gcd	594	40	T2	T2	NNP
cord-022594-fx044gcd	594	41	lesions	lesion	NNS
cord-022594-fx044gcd	594	42	with	with	IN
cord-022594-fx044gcd	594	43	positive	positive	JJ
cord-022594-fx044gcd	594	44	VEP	VEP	NNP
cord-022594-fx044gcd	594	45	)	)	-RRB-
cord-022594-fx044gcd	594	46	,	,	,
cord-022594-fx044gcd	594	47	(	(	-LRB-
cord-022594-fx044gcd	594	48	b	b	LS
cord-022594-fx044gcd	594	49	)	)	-RRB-
cord-022594-fx044gcd	594	50	positive	positive	JJ
cord-022594-fx044gcd	594	51	spinal	spinal	JJ
cord-022594-fx044gcd	594	52	cord	cord	NN
cord-022594-fx044gcd	594	53	MRI	MRI	NNP
cord-022594-fx044gcd	594	54	(	(	-LRB-
cord-022594-fx044gcd	594	55	two	two	CD
cord-022594-fx044gcd	594	56	focal	focal	JJ
cord-022594-fx044gcd	594	57	T2	T2	NNP
cord-022594-fx044gcd	594	58	lesions	lesion	NNS
cord-022594-fx044gcd	594	59	)	)	-RRB-
cord-022594-fx044gcd	594	60	,	,	,
cord-022594-fx044gcd	594	61	(	(	-LRB-
cord-022594-fx044gcd	594	62	c	c	NN
cord-022594-fx044gcd	594	63	)	)	-RRB-
cord-022594-fx044gcd	594	64	positive	positive	JJ
cord-022594-fx044gcd	594	65	CSF	CSF	NNP
cord-022594-fx044gcd	594	66	(	(	-LRB-
cord-022594-fx044gcd	594	67	isoelectric	isoelectric	VBN
cord-022594-fx044gcd	594	68	focusing	focus	VBG
cord-022594-fx044gcd	594	69	evidence	evidence	NN
cord-022594-fx044gcd	594	70	of	of	IN
cord-022594-fx044gcd	594	71	oligoclonal	oligoclonal	JJ
cord-022594-fx044gcd	594	72	IgG	IgG	NNP
cord-022594-fx044gcd	594	73	bands	band	NNS
cord-022594-fx044gcd	594	74	or	or	CC
cord-022594-fx044gcd	594	75	increased	increase	VBN
cord-022594-fx044gcd	594	76	IgG	IgG	NNP
cord-022594-fx044gcd	594	77	index	index	NN
cord-022594-fx044gcd	594	78	,	,	,
cord-022594-fx044gcd	594	79	or	or	CC
cord-022594-fx044gcd	594	80	both	both	DT
cord-022594-fx044gcd	594	81	)	)	-RRB-
cord-022594-fx044gcd	594	82	.	.	.
cord-022594-fx044gcd	595	1	Evoked	evoke	VBN
cord-022594-fx044gcd	595	2	potentials	potential	NNS
cord-022594-fx044gcd	595	3	are	be	VBP
cord-022594-fx044gcd	595	4	summed	sum	VBN
cord-022594-fx044gcd	595	5	cortical	cortical	JJ
cord-022594-fx044gcd	595	6	electrical	electrical	JJ
cord-022594-fx044gcd	595	7	responses	response	NNS
cord-022594-fx044gcd	595	8	to	to	IN
cord-022594-fx044gcd	595	9	peripheral	peripheral	JJ
cord-022594-fx044gcd	595	10	sensory	sensory	JJ
cord-022594-fx044gcd	595	11	stimulation	stimulation	NN
cord-022594-fx044gcd	595	12	that	that	WDT
cord-022594-fx044gcd	595	13	can	can	MD
cord-022594-fx044gcd	595	14	be	be	VB
cord-022594-fx044gcd	595	15	used	use	VBN
cord-022594-fx044gcd	595	16	to	to	TO
cord-022594-fx044gcd	595	17	localize	localize	VB
cord-022594-fx044gcd	595	18	sites	site	NNS
cord-022594-fx044gcd	595	19	of	of	IN
cord-022594-fx044gcd	595	20	disease	disease	NN
cord-022594-fx044gcd	595	21	and	and	CC
cord-022594-fx044gcd	595	22	measure	measure	NN
cord-022594-fx044gcd	595	23	conduction	conduction	NN
cord-022594-fx044gcd	595	24	velocity	velocity	NN
cord-022594-fx044gcd	595	25	along	along	IN
cord-022594-fx044gcd	595	26	sensory	sensory	JJ
cord-022594-fx044gcd	595	27	pathways	pathway	NNS
cord-022594-fx044gcd	595	28	.	.	.
cord-022594-fx044gcd	596	1	VEP	VEP	NNP
cord-022594-fx044gcd	596	2	and	and	CC
cord-022594-fx044gcd	596	3	somatosensory	somatosensory	NN
cord-022594-fx044gcd	596	4	evoked	evoke	VBN
cord-022594-fx044gcd	596	5	potentials	potential	NNS
cord-022594-fx044gcd	596	6	(	(	-LRB-
cord-022594-fx044gcd	596	7	SSEPs	ssep	NNS
cord-022594-fx044gcd	596	8	)	)	-RRB-
cord-022594-fx044gcd	596	9	may	may	MD
cord-022594-fx044gcd	596	10	detect	detect	VB
cord-022594-fx044gcd	596	11	subclinical	subclinical	JJ
cord-022594-fx044gcd	596	12	sites	site	NNS
cord-022594-fx044gcd	596	13	of	of	IN
cord-022594-fx044gcd	596	14	demyelination	demyelination	NN
cord-022594-fx044gcd	596	15	,	,	,
cord-022594-fx044gcd	596	16	thus	thus	RB
cord-022594-fx044gcd	596	17	providing	provide	VBG
cord-022594-fx044gcd	596	18	evidence	evidence	NN
cord-022594-fx044gcd	596	19	of	of	IN
cord-022594-fx044gcd	596	20	multifocality	multifocality	NN
cord-022594-fx044gcd	596	21	.	.	.
cord-022594-fx044gcd	597	1	Brain	brain	NN
cord-022594-fx044gcd	597	2	stem	stem	NN
cord-022594-fx044gcd	597	3	auditory	auditory	JJ
cord-022594-fx044gcd	597	4	evoked	evoke	VBN
cord-022594-fx044gcd	597	5	potentials	potential	NNS
cord-022594-fx044gcd	597	6	(	(	-LRB-
cord-022594-fx044gcd	597	7	BAEPs	baep	NNS
cord-022594-fx044gcd	597	8	)	)	-RRB-
cord-022594-fx044gcd	597	9	are	be	VBP
cord-022594-fx044gcd	597	10	occasionally	occasionally	RB
cord-022594-fx044gcd	597	11	informative	informative	JJ
cord-022594-fx044gcd	597	12	.	.	.
cord-022594-fx044gcd	598	1	More	More	JJR
cord-022594-fx044gcd	598	2	than	than	IN
cord-022594-fx044gcd	598	3	90	90	CD
cord-022594-fx044gcd	598	4	%	%	NN
cord-022594-fx044gcd	598	5	of	of	IN
cord-022594-fx044gcd	598	6	persons	person	NNS
cord-022594-fx044gcd	598	7	with	with	IN
cord-022594-fx044gcd	598	8	a	a	DT
cord-022594-fx044gcd	598	9	history	history	NN
cord-022594-fx044gcd	598	10	of	of	IN
cord-022594-fx044gcd	598	11	ON	ON	NNP
cord-022594-fx044gcd	598	12	have	have	VBP
cord-022594-fx044gcd	598	13	an	an	DT
cord-022594-fx044gcd	598	14	abnormal	abnormal	JJ
cord-022594-fx044gcd	598	15	VEP	vep	NN
cord-022594-fx044gcd	598	16	,	,	,
cord-022594-fx044gcd	598	17	and	and	CC
cord-022594-fx044gcd	598	18	85	85	CD
cord-022594-fx044gcd	598	19	%	%	NN
cord-022594-fx044gcd	598	20	of	of	IN
cord-022594-fx044gcd	598	21	CDMS	CDMS	NNP
cord-022594-fx044gcd	598	22	patients	patient	NNS
cord-022594-fx044gcd	598	23	have	have	VBP
cord-022594-fx044gcd	598	24	abnormalities	abnormality	NNS
cord-022594-fx044gcd	598	25	on	on	IN
cord-022594-fx044gcd	598	26	VEPs	vep	NNS
cord-022594-fx044gcd	598	27	even	even	RB
cord-022594-fx044gcd	598	28	when	when	WRB
cord-022594-fx044gcd	598	29	the	the	DT
cord-022594-fx044gcd	598	30	history	history	NN
cord-022594-fx044gcd	598	31	of	of	IN
cord-022594-fx044gcd	598	32	ON	ON	NNP
cord-022594-fx044gcd	598	33	is	be	VBZ
cord-022594-fx044gcd	598	34	absent	absent	JJ
cord-022594-fx044gcd	598	35	.	.	.
cord-022594-fx044gcd	599	1	Slowed	slowed	JJ
cord-022594-fx044gcd	599	2	conduction	conduction	NN
cord-022594-fx044gcd	599	3	is	be	VBZ
cord-022594-fx044gcd	599	4	present	present	JJ
cord-022594-fx044gcd	599	5	on	on	IN
cord-022594-fx044gcd	599	6	SSEP	SSEP	NNS
cord-022594-fx044gcd	599	7	in	in	IN
cord-022594-fx044gcd	599	8	nearly	nearly	RB
cord-022594-fx044gcd	599	9	three	three	CD
cord-022594-fx044gcd	599	10	fourths	fourth	NNS
cord-022594-fx044gcd	599	11	of	of	IN
cord-022594-fx044gcd	599	12	patients	patient	NNS
cord-022594-fx044gcd	599	13	with	with	IN
cord-022594-fx044gcd	599	14	CDMS	CDMS	NNP
cord-022594-fx044gcd	599	15	.	.	.
cord-022594-fx044gcd	600	1	BAEs	bae	NNS
cord-022594-fx044gcd	600	2	are	be	VBP
cord-022594-fx044gcd	600	3	the	the	DT
cord-022594-fx044gcd	600	4	least	least	RBS
cord-022594-fx044gcd	600	5	sensitive	sensitive	JJ
cord-022594-fx044gcd	600	6	,	,	,
cord-022594-fx044gcd	600	7	with	with	IN
cord-022594-fx044gcd	600	8	abnormalities	abnormality	NNS
cord-022594-fx044gcd	600	9	in	in	IN
cord-022594-fx044gcd	600	10	less	less	JJR
cord-022594-fx044gcd	600	11	than	than	IN
cord-022594-fx044gcd	600	12	50	50	CD
cord-022594-fx044gcd	600	13	%	%	NN
cord-022594-fx044gcd	600	14	.	.	.
cord-022594-fx044gcd	601	1	MRI	MRI	NNP
cord-022594-fx044gcd	601	2	has	have	VBZ
cord-022594-fx044gcd	601	3	largely	largely	RB
cord-022594-fx044gcd	601	4	supplanted	supplant	VBN
cord-022594-fx044gcd	601	5	the	the	DT
cord-022594-fx044gcd	601	6	use	use	NN
cord-022594-fx044gcd	601	7	of	of	IN
cord-022594-fx044gcd	601	8	evoked	evoke	VBN
cord-022594-fx044gcd	601	9	potentials	potential	NNS
cord-022594-fx044gcd	601	10	in	in	IN
cord-022594-fx044gcd	601	11	MS	MS	NNP
cord-022594-fx044gcd	601	12	because	because	IN
cord-022594-fx044gcd	601	13	of	of	IN
cord-022594-fx044gcd	601	14	the	the	DT
cord-022594-fx044gcd	601	15	greater	great	JJR
cord-022594-fx044gcd	601	16	sensitivity	sensitivity	NN
cord-022594-fx044gcd	601	17	in	in	IN
cord-022594-fx044gcd	601	18	the	the	DT
cord-022594-fx044gcd	601	19	diagnosis	diagnosis	NN
cord-022594-fx044gcd	601	20	and	and	CC
cord-022594-fx044gcd	601	21	the	the	DT
cord-022594-fx044gcd	601	22	detailed	detailed	JJ
cord-022594-fx044gcd	601	23	anatomical	anatomical	JJ
cord-022594-fx044gcd	601	24	information	information	NN
cord-022594-fx044gcd	601	25	it	-PRON-	PRP
cord-022594-fx044gcd	601	26	provides	provide	VBZ
cord-022594-fx044gcd	601	27	.	.	.
cord-022594-fx044gcd	602	1	In	in	IN
cord-022594-fx044gcd	602	2	2001	2001	CD
cord-022594-fx044gcd	602	3	,	,	,
cord-022594-fx044gcd	602	4	the	the	DT
cord-022594-fx044gcd	602	5	American	American	NNP
cord-022594-fx044gcd	602	6	Academy	Academy	NNP
cord-022594-fx044gcd	602	7	of	of	IN
cord-022594-fx044gcd	602	8	Neurology	Neurology	NNP
cord-022594-fx044gcd	602	9	released	release	VBD
cord-022594-fx044gcd	602	10	practice	practice	NN
cord-022594-fx044gcd	602	11	parameters	parameter	NNS
cord-022594-fx044gcd	602	12	regarding	regard	VBG
cord-022594-fx044gcd	602	13	the	the	DT
cord-022594-fx044gcd	602	14	usefulness	usefulness	NN
cord-022594-fx044gcd	602	15	of	of	IN
cord-022594-fx044gcd	602	16	evoked	evoke	VBN
cord-022594-fx044gcd	602	17	potential	potential	JJ
cord-022594-fx044gcd	602	18	studies	study	NNS
cord-022594-fx044gcd	602	19	in	in	IN
cord-022594-fx044gcd	602	20	MS	MS	NNP
cord-022594-fx044gcd	602	21	.	.	.
cord-022594-fx044gcd	603	1	According	accord	VBG
cord-022594-fx044gcd	603	2	to	to	IN
cord-022594-fx044gcd	603	3	these	these	DT
cord-022594-fx044gcd	603	4	recommendations	recommendation	NNS
cord-022594-fx044gcd	603	5	,	,	,
cord-022594-fx044gcd	603	6	VEPs	vep	NNS
cord-022594-fx044gcd	603	7	are	be	VBP
cord-022594-fx044gcd	603	8	considered	consider	VBN
cord-022594-fx044gcd	603	9	probably	probably	RB
cord-022594-fx044gcd	603	10	useful	useful	JJ
cord-022594-fx044gcd	603	11	(	(	-LRB-
cord-022594-fx044gcd	603	12	class	class	NN
cord-022594-fx044gcd	603	13	II	II	NNP
cord-022594-fx044gcd	603	14	evidence	evidence	NN
cord-022594-fx044gcd	603	15	)	)	-RRB-
cord-022594-fx044gcd	603	16	to	to	TO
cord-022594-fx044gcd	603	17	identify	identify	VB
cord-022594-fx044gcd	603	18	patients	patient	NNS
cord-022594-fx044gcd	603	19	at	at	IN
cord-022594-fx044gcd	603	20	increased	increase	VBN
cord-022594-fx044gcd	603	21	risk	risk	NN
cord-022594-fx044gcd	603	22	for	for	IN
cord-022594-fx044gcd	603	23	developing	develop	VBG
cord-022594-fx044gcd	603	24	clinically	clinically	RB
cord-022594-fx044gcd	603	25	definite	definite	JJ
cord-022594-fx044gcd	603	26	MS	m	NNS
cord-022594-fx044gcd	603	27	.	.	.
cord-022594-fx044gcd	604	1	SSEPs	ssep	NNS
cord-022594-fx044gcd	604	2	are	be	VBP
cord-022594-fx044gcd	604	3	possibly	possibly	RB
cord-022594-fx044gcd	604	4	useful	useful	JJ
cord-022594-fx044gcd	604	5	,	,	,
cord-022594-fx044gcd	604	6	whereas	whereas	IN
cord-022594-fx044gcd	604	7	the	the	DT
cord-022594-fx044gcd	604	8	evidence	evidence	NN
cord-022594-fx044gcd	604	9	for	for	IN
cord-022594-fx044gcd	604	10	BAEPs	baep	NNS
cord-022594-fx044gcd	604	11	supporting	support	VBG
cord-022594-fx044gcd	604	12	the	the	DT
cord-022594-fx044gcd	604	13	diagnosis	diagnosis	NN
cord-022594-fx044gcd	604	14	of	of	IN
cord-022594-fx044gcd	604	15	CDMS	CDMS	NNP
cord-022594-fx044gcd	604	16	is	be	VBZ
cord-022594-fx044gcd	604	17	insufficient	insufficient	JJ
cord-022594-fx044gcd	604	18	.	.	.
cord-022594-fx044gcd	605	1	MANAGEMENT	management	NN
cord-022594-fx044gcd	605	2	.	.	.
cord-022594-fx044gcd	606	1	There	there	EX
cord-022594-fx044gcd	606	2	is	be	VBZ
cord-022594-fx044gcd	606	3	no	no	DT
cord-022594-fx044gcd	606	4	available	available	JJ
cord-022594-fx044gcd	606	5	prevention	prevention	NN
cord-022594-fx044gcd	606	6	or	or	CC
cord-022594-fx044gcd	606	7	cure	cure	NN
cord-022594-fx044gcd	606	8	for	for	IN
cord-022594-fx044gcd	606	9	MS	MS	NNP
cord-022594-fx044gcd	606	10	.	.	.
cord-022594-fx044gcd	607	1	Treatments	treatment	NNS
cord-022594-fx044gcd	607	2	focus	focus	VBP
cord-022594-fx044gcd	607	3	on	on	IN
cord-022594-fx044gcd	607	4	three	three	CD
cord-022594-fx044gcd	607	5	areas	area	NNS
cord-022594-fx044gcd	607	6	:	:	:
cord-022594-fx044gcd	607	7	treating	treat	VBG
cord-022594-fx044gcd	607	8	acute	acute	JJ
cord-022594-fx044gcd	607	9	exacerbations	exacerbation	NNS
cord-022594-fx044gcd	607	10	and	and	CC
cord-022594-fx044gcd	607	11	hastening	hasten	VBG
cord-022594-fx044gcd	607	12	their	-PRON-	PRP$
cord-022594-fx044gcd	607	13	recovery	recovery	NN
cord-022594-fx044gcd	607	14	;	;	:
cord-022594-fx044gcd	607	15	altering	alter	VBG
cord-022594-fx044gcd	607	16	the	the	DT
cord-022594-fx044gcd	607	17	natural	natural	JJ
cord-022594-fx044gcd	607	18	history	history	NN
cord-022594-fx044gcd	607	19	of	of	IN
cord-022594-fx044gcd	607	20	MS	MS	NNP
cord-022594-fx044gcd	607	21	;	;	:
cord-022594-fx044gcd	607	22	and	and	CC
cord-022594-fx044gcd	607	23	providing	provide	VBG
cord-022594-fx044gcd	607	24	symptomatic	symptomatic	JJ
cord-022594-fx044gcd	607	25	relief	relief	NN
cord-022594-fx044gcd	607	26	of	of	IN
cord-022594-fx044gcd	607	27	current	current	JJ
cord-022594-fx044gcd	607	28	symptoms	symptom	NNS
cord-022594-fx044gcd	607	29	by	by	IN
cord-022594-fx044gcd	607	30	enhancing	enhance	VBG
cord-022594-fx044gcd	607	31	physical	physical	JJ
cord-022594-fx044gcd	607	32	abilities	ability	NNS
cord-022594-fx044gcd	607	33	and	and	CC
cord-022594-fx044gcd	607	34	preventing	prevent	VBG
cord-022594-fx044gcd	607	35	or	or	CC
cord-022594-fx044gcd	607	36	treating	treat	VBG
cord-022594-fx044gcd	607	37	complications	complication	NNS
cord-022594-fx044gcd	607	38	.	.	.
cord-022594-fx044gcd	608	1	A	a	DT
cord-022594-fx044gcd	608	2	fourth	fourth	JJ
cord-022594-fx044gcd	608	3	management	management	NN
cord-022594-fx044gcd	608	4	topic	topic	NN
cord-022594-fx044gcd	608	5	concerns	concern	VBZ
cord-022594-fx044gcd	608	6	special	special	JJ
cord-022594-fx044gcd	608	7	treatment	treatment	NN
cord-022594-fx044gcd	608	8	issues	issue	NNS
cord-022594-fx044gcd	608	9	related	relate	VBN
cord-022594-fx044gcd	608	10	to	to	IN
cord-022594-fx044gcd	608	11	pregnancy	pregnancy	NN
cord-022594-fx044gcd	608	12	.	.	.
cord-022594-fx044gcd	609	1	Acute	Acute	NNP
cord-022594-fx044gcd	609	2	Exacerbations	Exacerbations	NNPS
cord-022594-fx044gcd	609	3	.	.	.
cord-022594-fx044gcd	610	1	Corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	610	2	are	be	VBP
cord-022594-fx044gcd	610	3	the	the	DT
cord-022594-fx044gcd	610	4	most	most	RBS
cord-022594-fx044gcd	610	5	commonly	commonly	RB
cord-022594-fx044gcd	610	6	used	use	VBN
cord-022594-fx044gcd	610	7	treatment	treatment	NN
cord-022594-fx044gcd	610	8	for	for	IN
cord-022594-fx044gcd	610	9	MS	MS	NNP
cord-022594-fx044gcd	610	10	,	,	,
cord-022594-fx044gcd	610	11	although	although	IN
cord-022594-fx044gcd	610	12	there	there	EX
cord-022594-fx044gcd	610	13	have	have	VBP
cord-022594-fx044gcd	610	14	been	be	VBN
cord-022594-fx044gcd	610	15	few	few	JJ
cord-022594-fx044gcd	610	16	studies	study	NNS
cord-022594-fx044gcd	610	17	to	to	TO
cord-022594-fx044gcd	610	18	address	address	VB
cord-022594-fx044gcd	610	19	their	-PRON-	PRP$
cord-022594-fx044gcd	610	20	efficacy	efficacy	NN
cord-022594-fx044gcd	610	21	.	.	.
cord-022594-fx044gcd	611	1	Adrenocorticotropic	Adrenocorticotropic	NNP
cord-022594-fx044gcd	611	2	hormone	hormone	NN
cord-022594-fx044gcd	611	3	(	(	-LRB-
cord-022594-fx044gcd	611	4	ACTH	ACTH	NNP
cord-022594-fx044gcd	611	5	)	)	-RRB-
cord-022594-fx044gcd	611	6	was	be	VBD
cord-022594-fx044gcd	611	7	shown	show	VBN
cord-022594-fx044gcd	611	8	to	to	TO
cord-022594-fx044gcd	611	9	speed	speed	VB
cord-022594-fx044gcd	611	10	recovery	recovery	NN
cord-022594-fx044gcd	611	11	from	from	IN
cord-022594-fx044gcd	611	12	an	an	DT
cord-022594-fx044gcd	611	13	exacerbation	exacerbation	NN
cord-022594-fx044gcd	611	14	but	but	CC
cord-022594-fx044gcd	611	15	had	have	VBD
cord-022594-fx044gcd	611	16	no	no	DT
cord-022594-fx044gcd	611	17	effect	effect	NN
cord-022594-fx044gcd	611	18	on	on	IN
cord-022594-fx044gcd	611	19	the	the	DT
cord-022594-fx044gcd	611	20	ultimate	ultimate	JJ
cord-022594-fx044gcd	611	21	degree	degree	NN
cord-022594-fx044gcd	611	22	of	of	IN
cord-022594-fx044gcd	611	23	recovery	recovery	NN
cord-022594-fx044gcd	611	24	.	.	.
cord-022594-fx044gcd	612	1	Because	because	IN
cord-022594-fx044gcd	612	2	of	of	IN
cord-022594-fx044gcd	612	3	the	the	DT
cord-022594-fx044gcd	612	4	unpredictable	unpredictable	JJ
cord-022594-fx044gcd	612	5	cortisone	cortisone	NN
cord-022594-fx044gcd	612	6	response	response	NN
cord-022594-fx044gcd	612	7	to	to	IN
cord-022594-fx044gcd	612	8	ACTH	ACTH	NNP
cord-022594-fx044gcd	612	9	,	,	,
cord-022594-fx044gcd	612	10	oral	oral	JJ
cord-022594-fx044gcd	612	11	prednisone	prednisone	NN
cord-022594-fx044gcd	612	12	and	and	CC
cord-022594-fx044gcd	612	13	later	later	JJ
cord-022594-fx044gcd	612	14	intravenous	intravenous	JJ
cord-022594-fx044gcd	612	15	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	612	16	became	become	VBD
cord-022594-fx044gcd	612	17	the	the	DT
cord-022594-fx044gcd	612	18	preferred	preferred	JJ
cord-022594-fx044gcd	612	19	treatments	treatment	NNS
cord-022594-fx044gcd	612	20	.	.	.
cord-022594-fx044gcd	613	1	The	the	DT
cord-022594-fx044gcd	613	2	Optic	Optic	NNP
cord-022594-fx044gcd	613	3	Neuritis	Neuritis	NNP
cord-022594-fx044gcd	613	4	Treatment	Treatment	NNP
cord-022594-fx044gcd	613	5	Trial	Trial	NNP
cord-022594-fx044gcd	613	6	verified	verify	VBD
cord-022594-fx044gcd	613	7	that	that	IN
cord-022594-fx044gcd	613	8	intravenous	intravenous	JJ
cord-022594-fx044gcd	613	9	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	613	10	but	but	CC
cord-022594-fx044gcd	613	11	not	not	RB
cord-022594-fx044gcd	613	12	prednisone	prednisone	NNP
cord-022594-fx044gcd	613	13	increased	increase	VBD
cord-022594-fx044gcd	613	14	the	the	DT
cord-022594-fx044gcd	613	15	recovery	recovery	NN
cord-022594-fx044gcd	613	16	rate	rate	NN
cord-022594-fx044gcd	613	17	and	and	CC
cord-022594-fx044gcd	613	18	unexpectedly	unexpectedly	RB
cord-022594-fx044gcd	613	19	increased	increase	VBD
cord-022594-fx044gcd	613	20	the	the	DT
cord-022594-fx044gcd	613	21	time	time	NN
cord-022594-fx044gcd	613	22	to	to	IN
cord-022594-fx044gcd	613	23	the	the	DT
cord-022594-fx044gcd	613	24	next	next	JJ
cord-022594-fx044gcd	613	25	relapse	relapse	NN
cord-022594-fx044gcd	613	26	,	,	,
cord-022594-fx044gcd	613	27	thus	thus	RB
cord-022594-fx044gcd	613	28	delaying	delay	VBG
cord-022594-fx044gcd	613	29	the	the	DT
cord-022594-fx044gcd	613	30	diagnosis	diagnosis	NN
cord-022594-fx044gcd	613	31	of	of	IN
cord-022594-fx044gcd	613	32	CDMS	CDMS	NNP
cord-022594-fx044gcd	613	33	.	.	.
cord-022594-fx044gcd	614	1	54	54	CD
cord-022594-fx044gcd	615	1	Moreover	moreover	RB
cord-022594-fx044gcd	615	2	,	,	,
cord-022594-fx044gcd	615	3	the	the	DT
cord-022594-fx044gcd	615	4	prednisone	prednisone	NN
cord-022594-fx044gcd	615	5	-	-	HYPH
cord-022594-fx044gcd	615	6	treated	treat	VBN
cord-022594-fx044gcd	615	7	group	group	NN
cord-022594-fx044gcd	615	8	had	have	VBD
cord-022594-fx044gcd	615	9	twice	twice	RB
cord-022594-fx044gcd	615	10	as	as	RB
cord-022594-fx044gcd	615	11	many	many	JJ
cord-022594-fx044gcd	615	12	recurrences	recurrence	NNS
cord-022594-fx044gcd	615	13	.	.	.
cord-022594-fx044gcd	616	1	The	the	DT
cord-022594-fx044gcd	616	2	finding	finding	NN
cord-022594-fx044gcd	616	3	was	be	VBD
cord-022594-fx044gcd	616	4	not	not	RB
cord-022594-fx044gcd	616	5	replicated	replicate	VBN
cord-022594-fx044gcd	616	6	in	in	IN
cord-022594-fx044gcd	616	7	a	a	DT
cord-022594-fx044gcd	616	8	second	second	JJ
cord-022594-fx044gcd	616	9	study	study	NN
cord-022594-fx044gcd	616	10	,	,	,
cord-022594-fx044gcd	616	11	but	but	CC
cord-022594-fx044gcd	616	12	it	-PRON-	PRP
cord-022594-fx044gcd	616	13	has	have	VBZ
cord-022594-fx044gcd	616	14	affected	affect	VBN
cord-022594-fx044gcd	616	15	the	the	DT
cord-022594-fx044gcd	616	16	practice	practice	NN
cord-022594-fx044gcd	616	17	of	of	IN
cord-022594-fx044gcd	616	18	treating	treat	VBG
cord-022594-fx044gcd	616	19	acute	acute	JJ
cord-022594-fx044gcd	616	20	MS	MS	NNP
cord-022594-fx044gcd	616	21	exacerbations	exacerbation	NNS
cord-022594-fx044gcd	616	22	.	.	.
cord-022594-fx044gcd	617	1	The	the	DT
cord-022594-fx044gcd	617	2	current	current	JJ
cord-022594-fx044gcd	617	3	recommendation	recommendation	NN
cord-022594-fx044gcd	617	4	is	be	VBZ
cord-022594-fx044gcd	617	5	to	to	TO
cord-022594-fx044gcd	617	6	treat	treat	VB
cord-022594-fx044gcd	617	7	disabling	disable	VBG
cord-022594-fx044gcd	617	8	attacks	attack	NNS
cord-022594-fx044gcd	617	9	with	with	IN
cord-022594-fx044gcd	617	10	500	500	CD
cord-022594-fx044gcd	617	11	to	to	TO
cord-022594-fx044gcd	617	12	1000	1000	CD
cord-022594-fx044gcd	617	13	mg	mg	NN
cord-022594-fx044gcd	617	14	of	of	IN
cord-022594-fx044gcd	617	15	intravenous	intravenous	JJ
cord-022594-fx044gcd	617	16	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	617	17	per	per	IN
cord-022594-fx044gcd	617	18	day	day	NN
cord-022594-fx044gcd	617	19	for	for	IN
cord-022594-fx044gcd	617	20	3	3	CD
cord-022594-fx044gcd	617	21	to	to	TO
cord-022594-fx044gcd	617	22	5	5	CD
cord-022594-fx044gcd	617	23	days	day	NNS
cord-022594-fx044gcd	617	24	with	with	IN
cord-022594-fx044gcd	617	25	or	or	CC
cord-022594-fx044gcd	617	26	without	without	IN
cord-022594-fx044gcd	617	27	a	a	DT
cord-022594-fx044gcd	617	28	short	short	JJ
cord-022594-fx044gcd	617	29	tapering	tapering	NN
cord-022594-fx044gcd	617	30	dose	dose	NN
cord-022594-fx044gcd	617	31	of	of	IN
cord-022594-fx044gcd	617	32	oral	oral	JJ
cord-022594-fx044gcd	617	33	corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	617	34	.	.	.
cord-022594-fx044gcd	618	1	According	accord	VBG
cord-022594-fx044gcd	618	2	to	to	IN
cord-022594-fx044gcd	618	3	the	the	DT
cord-022594-fx044gcd	618	4	practice	practice	NN
cord-022594-fx044gcd	618	5	parameters	parameter	NNS
cord-022594-fx044gcd	618	6	for	for	IN
cord-022594-fx044gcd	618	7	steroid	steroid	NN
cord-022594-fx044gcd	618	8	treatment	treatment	NN
cord-022594-fx044gcd	618	9	of	of	IN
cord-022594-fx044gcd	618	10	acute	acute	JJ
cord-022594-fx044gcd	618	11	ON	on	IN
cord-022594-fx044gcd	618	12	attacks	attack	NNS
cord-022594-fx044gcd	618	13	released	release	VBN
cord-022594-fx044gcd	618	14	by	by	IN
cord-022594-fx044gcd	618	15	the	the	DT
cord-022594-fx044gcd	618	16	American	American	NNP
cord-022594-fx044gcd	618	17	Academy	Academy	NNP
cord-022594-fx044gcd	618	18	of	of	IN
cord-022594-fx044gcd	618	19	Neurology	Neurology	NNP
cord-022594-fx044gcd	618	20	in	in	IN
cord-022594-fx044gcd	618	21	2001	2001	CD
cord-022594-fx044gcd	618	22	,	,	,
cord-022594-fx044gcd	618	23	oral	oral	JJ
cord-022594-fx044gcd	618	24	prednisone	prednisone	NN
cord-022594-fx044gcd	618	25	in	in	IN
cord-022594-fx044gcd	618	26	doses	dose	NNS
cord-022594-fx044gcd	618	27	of	of	IN
cord-022594-fx044gcd	618	28	1	1	CD
cord-022594-fx044gcd	618	29	mg	mg	NNP
cord-022594-fx044gcd	618	30	/	/	SYM
cord-022594-fx044gcd	618	31	kg	kg	NNP
cord-022594-fx044gcd	618	32	/	/	SYM
cord-022594-fx044gcd	618	33	day	day	NN
cord-022594-fx044gcd	618	34	has	have	VBZ
cord-022594-fx044gcd	618	35	no	no	DT
cord-022594-fx044gcd	618	36	proven	prove	VBN
cord-022594-fx044gcd	618	37	value	value	NN
cord-022594-fx044gcd	618	38	.	.	.
cord-022594-fx044gcd	619	1	Higher	high	JJR
cord-022594-fx044gcd	619	2	dose	dose	NN
cord-022594-fx044gcd	619	3	of	of	IN
cord-022594-fx044gcd	619	4	oral	oral	JJ
cord-022594-fx044gcd	619	5	or	or	CC
cord-022594-fx044gcd	619	6	parenteral	parenteral	JJ
cord-022594-fx044gcd	619	7	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	619	8	may	may	MD
cord-022594-fx044gcd	619	9	result	result	VB
cord-022594-fx044gcd	619	10	in	in	IN
cord-022594-fx044gcd	619	11	quicker	quick	RBR
cord-022594-fx044gcd	619	12	and	and	CC
cord-022594-fx044gcd	619	13	more	more	RBR
cord-022594-fx044gcd	619	14	thorough	thorough	JJ
cord-022594-fx044gcd	619	15	recovery	recovery	NN
cord-022594-fx044gcd	619	16	of	of	IN
cord-022594-fx044gcd	619	17	visual	visual	JJ
cord-022594-fx044gcd	619	18	function	function	NN
cord-022594-fx044gcd	619	19	.	.	.
cord-022594-fx044gcd	620	1	There	there	EX
cord-022594-fx044gcd	620	2	is	be	VBZ
cord-022594-fx044gcd	620	3	no	no	DT
cord-022594-fx044gcd	620	4	evidence	evidence	NN
cord-022594-fx044gcd	620	5	of	of	IN
cord-022594-fx044gcd	620	6	long	long	JJ
cord-022594-fx044gcd	620	7	-	-	HYPH
cord-022594-fx044gcd	620	8	term	term	NN
cord-022594-fx044gcd	620	9	benefit	benefit	NN
cord-022594-fx044gcd	620	10	for	for	IN
cord-022594-fx044gcd	620	11	visual	visual	JJ
cord-022594-fx044gcd	620	12	function	function	NN
cord-022594-fx044gcd	620	13	.	.	.
cord-022594-fx044gcd	621	1	A	a	DT
cord-022594-fx044gcd	621	2	study	study	NN
cord-022594-fx044gcd	621	3	suggested	suggest	VBD
cord-022594-fx044gcd	621	4	that	that	IN
cord-022594-fx044gcd	621	5	intravenous	intravenous	JJ
cord-022594-fx044gcd	621	6	steroids	steroid	NNS
cord-022594-fx044gcd	621	7	may	may	MD
cord-022594-fx044gcd	621	8	also	also	RB
cord-022594-fx044gcd	621	9	have	have	VB
cord-022594-fx044gcd	621	10	long	long	JJ
cord-022594-fx044gcd	621	11	-	-	HYPH
cord-022594-fx044gcd	621	12	term	term	NN
cord-022594-fx044gcd	621	13	effects	effect	NNS
cord-022594-fx044gcd	621	14	on	on	IN
cord-022594-fx044gcd	621	15	disease	disease	NN
cord-022594-fx044gcd	621	16	progression	progression	NN
cord-022594-fx044gcd	621	17	when	when	WRB
cord-022594-fx044gcd	621	18	given	give	VBN
cord-022594-fx044gcd	621	19	regularly	regularly	RB
cord-022594-fx044gcd	621	20	.	.	.
cord-022594-fx044gcd	622	1	55	55	CD
cord-022594-fx044gcd	623	1	In	in	IN
cord-022594-fx044gcd	623	2	this	this	DT
cord-022594-fx044gcd	623	3	study	study	NN
cord-022594-fx044gcd	623	4	,	,	,
cord-022594-fx044gcd	623	5	RRMS	RRMS	NNP
cord-022594-fx044gcd	623	6	patients	patient	NNS
cord-022594-fx044gcd	623	7	randomized	randomize	VBN
cord-022594-fx044gcd	623	8	to	to	TO
cord-022594-fx044gcd	623	9	receive	receive	VB
cord-022594-fx044gcd	623	10	regularly	regularly	RB
cord-022594-fx044gcd	623	11	scheduled	schedule	VBN
cord-022594-fx044gcd	623	12	pulses	pulse	NNS
cord-022594-fx044gcd	623	13	of	of	IN
cord-022594-fx044gcd	623	14	IV	IV	NNP
cord-022594-fx044gcd	623	15	methylprednisolone	methylprednisolone	NNP
cord-022594-fx044gcd	623	16	(	(	-LRB-
cord-022594-fx044gcd	623	17	every	every	DT
cord-022594-fx044gcd	623	18	4	4	CD
cord-022594-fx044gcd	623	19	months	month	NNS
cord-022594-fx044gcd	623	20	for	for	IN
cord-022594-fx044gcd	623	21	3	3	CD
cord-022594-fx044gcd	623	22	years	year	NNS
cord-022594-fx044gcd	623	23	,	,	,
cord-022594-fx044gcd	623	24	then	then	RB
cord-022594-fx044gcd	623	25	every	every	DT
cord-022594-fx044gcd	623	26	6	6	CD
cord-022594-fx044gcd	623	27	months	month	NNS
cord-022594-fx044gcd	623	28	for	for	IN
cord-022594-fx044gcd	623	29	2	2	CD
cord-022594-fx044gcd	623	30	years	year	NNS
cord-022594-fx044gcd	623	31	)	)	-RRB-
cord-022594-fx044gcd	623	32	demonstrated	demonstrate	VBD
cord-022594-fx044gcd	623	33	stability	stability	NN
cord-022594-fx044gcd	623	34	or	or	CC
cord-022594-fx044gcd	623	35	improvement	improvement	NN
cord-022594-fx044gcd	623	36	in	in	IN
cord-022594-fx044gcd	623	37	disability	disability	NN
cord-022594-fx044gcd	623	38	measures	measure	NNS
cord-022594-fx044gcd	623	39	,	,	,
cord-022594-fx044gcd	623	40	fewer	few	JJR
cord-022594-fx044gcd	623	41	"	"	``
cord-022594-fx044gcd	623	42	T1	t1	NN
cord-022594-fx044gcd	623	43	black	black	JJ
cord-022594-fx044gcd	623	44	holes	hole	NNS
cord-022594-fx044gcd	623	45	,	,	,
cord-022594-fx044gcd	623	46	"	"	''
cord-022594-fx044gcd	623	47	and	and	CC
cord-022594-fx044gcd	623	48	less	less	JJR
cord-022594-fx044gcd	623	49	brain	brain	NN
cord-022594-fx044gcd	623	50	atrophy	atrophy	NN
cord-022594-fx044gcd	623	51	than	than	IN
cord-022594-fx044gcd	623	52	did	do	VBD
cord-022594-fx044gcd	623	53	control	control	NN
cord-022594-fx044gcd	623	54	patients	patient	NNS
cord-022594-fx044gcd	623	55	randomized	randomize	VBN
cord-022594-fx044gcd	623	56	to	to	TO
cord-022594-fx044gcd	623	57	receive	receive	VB
cord-022594-fx044gcd	623	58	steroids	steroid	NNS
cord-022594-fx044gcd	623	59	only	only	RB
cord-022594-fx044gcd	623	60	with	with	IN
cord-022594-fx044gcd	623	61	relapses	relapse	NNS
cord-022594-fx044gcd	623	62	.	.	.
cord-022594-fx044gcd	624	1	These	these	DT
cord-022594-fx044gcd	624	2	findings	finding	NNS
cord-022594-fx044gcd	624	3	suggest	suggest	VBP
cord-022594-fx044gcd	624	4	a	a	DT
cord-022594-fx044gcd	624	5	possible	possible	JJ
cord-022594-fx044gcd	624	6	long	long	JJ
cord-022594-fx044gcd	624	7	-	-	HYPH
cord-022594-fx044gcd	624	8	term	term	NN
cord-022594-fx044gcd	624	9	benefit	benefit	NN
cord-022594-fx044gcd	624	10	of	of	IN
cord-022594-fx044gcd	624	11	pulsed	pulse	VBN
cord-022594-fx044gcd	624	12	IV	IV	NNP
cord-022594-fx044gcd	624	13	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	624	14	therapy	therapy	NN
cord-022594-fx044gcd	624	15	on	on	IN
cord-022594-fx044gcd	624	16	brain	brain	NN
cord-022594-fx044gcd	624	17	atrophy	atrophy	NN
cord-022594-fx044gcd	624	18	and	and	CC
cord-022594-fx044gcd	624	19	disability	disability	NN
cord-022594-fx044gcd	624	20	.	.	.
cord-022594-fx044gcd	625	1	This	this	DT
cord-022594-fx044gcd	625	2	as	as	IN
cord-022594-fx044gcd	625	3	yet	yet	RB
cord-022594-fx044gcd	625	4	unconfirmed	unconfirmed	JJ
cord-022594-fx044gcd	625	5	approach	approach	NN
cord-022594-fx044gcd	625	6	to	to	IN
cord-022594-fx044gcd	625	7	long	long	JJ
cord-022594-fx044gcd	625	8	-	-	HYPH
cord-022594-fx044gcd	625	9	term	term	NN
cord-022594-fx044gcd	625	10	therapy	therapy	NN
cord-022594-fx044gcd	625	11	might	may	MD
cord-022594-fx044gcd	625	12	be	be	VB
cord-022594-fx044gcd	625	13	considered	consider	VBN
cord-022594-fx044gcd	625	14	a	a	DT
cord-022594-fx044gcd	625	15	reasonable	reasonable	JJ
cord-022594-fx044gcd	625	16	"	"	``
cord-022594-fx044gcd	625	17	control	control	NN
cord-022594-fx044gcd	625	18	arm	arm	NN
cord-022594-fx044gcd	625	19	"	"	''
cord-022594-fx044gcd	625	20	in	in	IN
cord-022594-fx044gcd	625	21	future	future	JJ
cord-022594-fx044gcd	625	22	phase	phase	NN
cord-022594-fx044gcd	625	23	III	iii	CD
cord-022594-fx044gcd	625	24	trials	trial	NNS
cord-022594-fx044gcd	625	25	of	of	IN
cord-022594-fx044gcd	625	26	experimental	experimental	JJ
cord-022594-fx044gcd	625	27	therapies	therapy	NNS
cord-022594-fx044gcd	625	28	.	.	.
cord-022594-fx044gcd	626	1	Up	up	IN
cord-022594-fx044gcd	626	2	to	to	TO
cord-022594-fx044gcd	626	3	one	one	CD
cord-022594-fx044gcd	626	4	third	third	NN
cord-022594-fx044gcd	626	5	of	of	IN
cord-022594-fx044gcd	626	6	patients	patient	NNS
cord-022594-fx044gcd	626	7	do	do	VBP
cord-022594-fx044gcd	626	8	not	not	RB
cord-022594-fx044gcd	626	9	have	have	VB
cord-022594-fx044gcd	626	10	an	an	DT
cord-022594-fx044gcd	626	11	adequate	adequate	JJ
cord-022594-fx044gcd	626	12	recovery	recovery	NN
cord-022594-fx044gcd	626	13	after	after	IN
cord-022594-fx044gcd	626	14	a	a	DT
cord-022594-fx044gcd	626	15	relapse	relapse	NN
cord-022594-fx044gcd	626	16	despite	despite	IN
cord-022594-fx044gcd	626	17	the	the	DT
cord-022594-fx044gcd	626	18	use	use	NN
cord-022594-fx044gcd	626	19	of	of	IN
cord-022594-fx044gcd	626	20	corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	626	21	.	.	.
cord-022594-fx044gcd	627	1	Plasma	plasma	NN
cord-022594-fx044gcd	627	2	exchange	exchange	NN
cord-022594-fx044gcd	627	3	(	(	-LRB-
cord-022594-fx044gcd	627	4	PLEX	PLEX	NNP
cord-022594-fx044gcd	627	5	)	)	-RRB-
cord-022594-fx044gcd	627	6	alone	alone	RB
cord-022594-fx044gcd	627	7	was	be	VBD
cord-022594-fx044gcd	627	8	found	find	VBN
cord-022594-fx044gcd	627	9	beneficial	beneficial	JJ
cord-022594-fx044gcd	627	10	in	in	IN
cord-022594-fx044gcd	627	11	a	a	DT
cord-022594-fx044gcd	627	12	substantial	substantial	JJ
cord-022594-fx044gcd	627	13	proportion	proportion	NN
cord-022594-fx044gcd	627	14	of	of	IN
cord-022594-fx044gcd	627	15	patients	patient	NNS
cord-022594-fx044gcd	627	16	with	with	IN
cord-022594-fx044gcd	627	17	severe	severe	JJ
cord-022594-fx044gcd	627	18	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	627	19	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	627	20	episodes	episode	NNS
cord-022594-fx044gcd	627	21	who	who	WP
cord-022594-fx044gcd	627	22	had	have	VBD
cord-022594-fx044gcd	627	23	failed	fail	VBN
cord-022594-fx044gcd	627	24	to	to	TO
cord-022594-fx044gcd	627	25	improve	improve	VB
cord-022594-fx044gcd	627	26	following	follow	VBG
cord-022594-fx044gcd	627	27	treatment	treatment	NN
cord-022594-fx044gcd	627	28	with	with	IN
cord-022594-fx044gcd	627	29	high	high	JJ
cord-022594-fx044gcd	627	30	-	-	HYPH
cord-022594-fx044gcd	627	31	dose	dose	NN
cord-022594-fx044gcd	627	32	IV	IV	NNP
cord-022594-fx044gcd	627	33	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	627	34	.	.	.
cord-022594-fx044gcd	628	1	56	56	CD
cord-022594-fx044gcd	628	2	,	,	,
cord-022594-fx044gcd	628	3	57	57	CD
cord-022594-fx044gcd	629	1	A	a	DT
cord-022594-fx044gcd	629	2	randomized	randomized	JJ
cord-022594-fx044gcd	629	3	,	,	,
cord-022594-fx044gcd	629	4	sham	sham	NN
cord-022594-fx044gcd	629	5	-	-	HYPH
cord-022594-fx044gcd	629	6	controlled	control	VBN
cord-022594-fx044gcd	629	7	,	,	,
cord-022594-fx044gcd	629	8	double	double	JJ
cord-022594-fx044gcd	629	9	-	-	HYPH
cord-022594-fx044gcd	629	10	blind	blind	JJ
cord-022594-fx044gcd	629	11	trial	trial	NN
cord-022594-fx044gcd	629	12	in	in	IN
cord-022594-fx044gcd	629	13	22	22	CD
cord-022594-fx044gcd	629	14	patients	patient	NNS
cord-022594-fx044gcd	629	15	(	(	-LRB-
cord-022594-fx044gcd	629	16	seven	seven	CD
cord-022594-fx044gcd	629	17	exchanges	exchange	NNS
cord-022594-fx044gcd	629	18	over	over	IN
cord-022594-fx044gcd	629	19	14	14	CD
cord-022594-fx044gcd	629	20	days	day	NNS
cord-022594-fx044gcd	629	21	)	)	-RRB-
cord-022594-fx044gcd	629	22	without	without	IN
cord-022594-fx044gcd	629	23	concomitant	concomitant	JJ
cord-022594-fx044gcd	629	24	use	use	NN
cord-022594-fx044gcd	629	25	of	of	IN
cord-022594-fx044gcd	629	26	immunosuppressants	immunosuppressant	NNS
cord-022594-fx044gcd	629	27	in	in	IN
cord-022594-fx044gcd	629	28	acute	acute	JJ
cord-022594-fx044gcd	629	29	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	629	30	events	event	NNS
cord-022594-fx044gcd	629	31	confirmed	confirm	VBD
cord-022594-fx044gcd	629	32	these	these	DT
cord-022594-fx044gcd	629	33	findings	finding	NNS
cord-022594-fx044gcd	629	34	.	.	.
cord-022594-fx044gcd	630	1	58	58	CD
cord-022594-fx044gcd	630	2	Moderate	moderate	JJ
cord-022594-fx044gcd	630	3	or	or	CC
cord-022594-fx044gcd	630	4	greater	great	JJR
cord-022594-fx044gcd	630	5	clinical	clinical	JJ
cord-022594-fx044gcd	630	6	improvement	improvement	NN
cord-022594-fx044gcd	630	7	was	be	VBD
cord-022594-fx044gcd	630	8	observed	observe	VBN
cord-022594-fx044gcd	630	9	in	in	IN
cord-022594-fx044gcd	630	10	over	over	IN
cord-022594-fx044gcd	630	11	42	42	CD
cord-022594-fx044gcd	630	12	%	%	NN
cord-022594-fx044gcd	630	13	of	of	IN
cord-022594-fx044gcd	630	14	participants	participant	NNS
cord-022594-fx044gcd	630	15	.	.	.
cord-022594-fx044gcd	631	1	A	a	DT
cord-022594-fx044gcd	631	2	trial	trial	NN
cord-022594-fx044gcd	631	3	of	of	IN
cord-022594-fx044gcd	631	4	seven	seven	CD
cord-022594-fx044gcd	631	5	PLEX	PLEX	NNP
cord-022594-fx044gcd	631	6	treatments	treatment	NNS
cord-022594-fx044gcd	631	7	(	(	-LRB-
cord-022594-fx044gcd	631	8	alternate	alternate	JJ
cord-022594-fx044gcd	631	9	days	day	NNS
cord-022594-fx044gcd	631	10	)	)	-RRB-
cord-022594-fx044gcd	631	11	is	be	VBZ
cord-022594-fx044gcd	631	12	a	a	DT
cord-022594-fx044gcd	631	13	reasonable	reasonable	JJ
cord-022594-fx044gcd	631	14	option	option	NN
cord-022594-fx044gcd	631	15	for	for	IN
cord-022594-fx044gcd	631	16	patients	patient	NNS
cord-022594-fx044gcd	631	17	who	who	WP
cord-022594-fx044gcd	631	18	fail	fail	VBP
cord-022594-fx044gcd	631	19	to	to	TO
cord-022594-fx044gcd	631	20	respond	respond	VB
cord-022594-fx044gcd	631	21	to	to	IN
cord-022594-fx044gcd	631	22	conventional	conventional	JJ
cord-022594-fx044gcd	631	23	IV	IV	NNP
cord-022594-fx044gcd	631	24	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	631	25	therapy	therapy	NN
cord-022594-fx044gcd	631	26	in	in	IN
cord-022594-fx044gcd	631	27	acute	acute	JJ
cord-022594-fx044gcd	631	28	,	,	,
cord-022594-fx044gcd	631	29	severe	severe	JJ
cord-022594-fx044gcd	631	30	episodes	episode	NNS
cord-022594-fx044gcd	631	31	of	of	IN
cord-022594-fx044gcd	631	32	demyelinating	demyelinate	VBG
cord-022594-fx044gcd	631	33	diseases	disease	NNS
cord-022594-fx044gcd	631	34	.	.	.
cord-022594-fx044gcd	632	1	The	the	DT
cord-022594-fx044gcd	632	2	response	response	NN
cord-022594-fx044gcd	632	3	to	to	IN
cord-022594-fx044gcd	632	4	PLEX	PLEX	NNP
cord-022594-fx044gcd	632	5	is	be	VBZ
cord-022594-fx044gcd	632	6	stongly	stongly	RB
cord-022594-fx044gcd	632	7	associated	associate	VBN
cord-022594-fx044gcd	632	8	with	with	IN
cord-022594-fx044gcd	632	9	the	the	DT
cord-022594-fx044gcd	632	10	histological	histological	JJ
cord-022594-fx044gcd	632	11	MS	MS	NNP
cord-022594-fx044gcd	632	12	subtype	subtype	NN
cord-022594-fx044gcd	632	13	.	.	.
cord-022594-fx044gcd	633	1	59	59	CD
cord-022594-fx044gcd	633	2	Antibody	antibody	NN
cord-022594-fx044gcd	633	3	and	and	CC
cord-022594-fx044gcd	633	4	complement	complement	NN
cord-022594-fx044gcd	633	5	plays	play	VBZ
cord-022594-fx044gcd	633	6	a	a	DT
cord-022594-fx044gcd	633	7	crucial	crucial	JJ
cord-022594-fx044gcd	633	8	role	role	NN
cord-022594-fx044gcd	633	9	in	in	IN
cord-022594-fx044gcd	633	10	pattern	pattern	NN
cord-022594-fx044gcd	633	11	II	ii	CD
cord-022594-fx044gcd	633	12	lesion	lesion	NN
cord-022594-fx044gcd	633	13	formation	formation	NN
cord-022594-fx044gcd	633	14	.	.	.
cord-022594-fx044gcd	634	1	In	in	IN
cord-022594-fx044gcd	634	2	a	a	DT
cord-022594-fx044gcd	634	3	study	study	NN
cord-022594-fx044gcd	634	4	of	of	IN
cord-022594-fx044gcd	634	5	19	19	CD
cord-022594-fx044gcd	634	6	biopsy	biopsy	NN
cord-022594-fx044gcd	634	7	-	-	HYPH
cord-022594-fx044gcd	634	8	proven	prove	VBN
cord-022594-fx044gcd	634	9	MS	MS	NNP
cord-022594-fx044gcd	634	10	cases	case	NNS
cord-022594-fx044gcd	634	11	by	by	IN
cord-022594-fx044gcd	634	12	Keegan	Keegan	NNP
cord-022594-fx044gcd	634	13	and	and	CC
cord-022594-fx044gcd	634	14	associates	associate	NNS
cord-022594-fx044gcd	634	15	,	,	,
cord-022594-fx044gcd	634	16	10	10	CD
cord-022594-fx044gcd	634	17	pattern	pattern	NN
cord-022594-fx044gcd	634	18	II	ii	CD
cord-022594-fx044gcd	634	19	cases	case	NNS
cord-022594-fx044gcd	634	20	showed	show	VBD
cord-022594-fx044gcd	634	21	good	good	JJ
cord-022594-fx044gcd	634	22	response	response	NN
cord-022594-fx044gcd	634	23	to	to	IN
cord-022594-fx044gcd	634	24	PLEX	PLEX	NNP
cord-022594-fx044gcd	634	25	,	,	,
cord-022594-fx044gcd	634	26	whereas	whereas	IN
cord-022594-fx044gcd	634	27	9	9	CD
cord-022594-fx044gcd	634	28	cases	case	NNS
cord-022594-fx044gcd	634	29	of	of	IN
cord-022594-fx044gcd	634	30	pattern	pattern	NN
cord-022594-fx044gcd	634	31	I	-PRON-	PRP
cord-022594-fx044gcd	634	32	or	or	CC
cord-022594-fx044gcd	634	33	III	III	NNP
cord-022594-fx044gcd	634	34	did	do	VBD
cord-022594-fx044gcd	634	35	not	not	RB
cord-022594-fx044gcd	634	36	respond	respond	VB
cord-022594-fx044gcd	634	37	at	at	RB
cord-022594-fx044gcd	634	38	all	all	RB
cord-022594-fx044gcd	634	39	to	to	IN
cord-022594-fx044gcd	634	40	PLEX	PLEX	NNP
cord-022594-fx044gcd	634	41	.	.	.
cord-022594-fx044gcd	635	1	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	635	2	optica	optica	NN
cord-022594-fx044gcd	635	3	,	,	,
cord-022594-fx044gcd	635	4	which	which	WDT
cord-022594-fx044gcd	635	5	is	be	VBZ
cord-022594-fx044gcd	635	6	now	now	RB
cord-022594-fx044gcd	635	7	considered	consider	VBN
cord-022594-fx044gcd	635	8	an	an	DT
cord-022594-fx044gcd	635	9	antibody	antibody	NN
cord-022594-fx044gcd	635	10	-	-	HYPH
cord-022594-fx044gcd	635	11	mediated	mediate	VBN
cord-022594-fx044gcd	635	12	condition	condition	NN
cord-022594-fx044gcd	635	13	with	with	IN
cord-022594-fx044gcd	635	14	a	a	DT
cord-022594-fx044gcd	635	15	known	know	VBN
cord-022594-fx044gcd	635	16	serological	serological	JJ
cord-022594-fx044gcd	635	17	marker	marker	NN
cord-022594-fx044gcd	635	18	,	,	,
cord-022594-fx044gcd	635	19	also	also	RB
cord-022594-fx044gcd	635	20	shows	show	VBZ
cord-022594-fx044gcd	635	21	good	good	JJ
cord-022594-fx044gcd	635	22	response	response	NN
cord-022594-fx044gcd	635	23	to	to	IN
cord-022594-fx044gcd	635	24	PLEX	PLEX	NNP
cord-022594-fx044gcd	635	25	:	:	:
cord-022594-fx044gcd	635	26	in	in	IN
cord-022594-fx044gcd	635	27	a	a	DT
cord-022594-fx044gcd	635	28	study	study	NN
cord-022594-fx044gcd	635	29	by	by	IN
cord-022594-fx044gcd	635	30	the	the	DT
cord-022594-fx044gcd	635	31	Mayo	Mayo	NNP
cord-022594-fx044gcd	635	32	group	group	NN
cord-022594-fx044gcd	635	33	,	,	,
cord-022594-fx044gcd	635	34	60	60	CD
cord-022594-fx044gcd	635	35	%	%	NN
cord-022594-fx044gcd	635	36	of	of	IN
cord-022594-fx044gcd	635	37	NMO	NMO	NNP
cord-022594-fx044gcd	635	38	patients	patient	NNS
cord-022594-fx044gcd	635	39	showed	show	VBD
cord-022594-fx044gcd	635	40	moderate	moderate	JJ
cord-022594-fx044gcd	635	41	or	or	CC
cord-022594-fx044gcd	635	42	marked	marked	JJ
cord-022594-fx044gcd	635	43	improvement	improvement	NN
cord-022594-fx044gcd	635	44	to	to	IN
cord-022594-fx044gcd	635	45	PLEX	PLEX	NNP
cord-022594-fx044gcd	635	46	,	,	,
cord-022594-fx044gcd	635	47	and	and	CC
cord-022594-fx044gcd	635	48	an	an	DT
cord-022594-fx044gcd	635	49	additional	additional	JJ
cord-022594-fx044gcd	635	50	10	10	CD
cord-022594-fx044gcd	635	51	%	%	NN
cord-022594-fx044gcd	635	52	showed	show	VBD
cord-022594-fx044gcd	635	53	mild	mild	JJ
cord-022594-fx044gcd	635	54	improvement	improvement	NN
cord-022594-fx044gcd	635	55	.	.	.
cord-022594-fx044gcd	636	1	60	60	CD
cord-022594-fx044gcd	636	2	Alteration	alteration	NN
cord-022594-fx044gcd	636	3	of	of	IN
cord-022594-fx044gcd	636	4	the	the	DT
cord-022594-fx044gcd	636	5	Natural	Natural	NNP
cord-022594-fx044gcd	636	6	Course	Course	NNP
cord-022594-fx044gcd	636	7	.	.	.
cord-022594-fx044gcd	637	1	The	the	DT
cord-022594-fx044gcd	637	2	primary	primary	JJ
cord-022594-fx044gcd	637	3	goal	goal	NN
cord-022594-fx044gcd	637	4	of	of	IN
cord-022594-fx044gcd	637	5	drug	drug	NN
cord-022594-fx044gcd	637	6	treatment	treatment	NN
cord-022594-fx044gcd	637	7	is	be	VBZ
cord-022594-fx044gcd	637	8	to	to	TO
cord-022594-fx044gcd	637	9	alter	alter	VB
cord-022594-fx044gcd	637	10	the	the	DT
cord-022594-fx044gcd	637	11	natural	natural	JJ
cord-022594-fx044gcd	637	12	course	course	NN
cord-022594-fx044gcd	637	13	of	of	IN
cord-022594-fx044gcd	637	14	the	the	DT
cord-022594-fx044gcd	637	15	disease	disease	NN
cord-022594-fx044gcd	637	16	(	(	-LRB-
cord-022594-fx044gcd	637	17	e.g.	e.g.	RB
cord-022594-fx044gcd	637	18	,	,	,
cord-022594-fx044gcd	637	19	reducing	reduce	VBG
cord-022594-fx044gcd	637	20	the	the	DT
cord-022594-fx044gcd	637	21	frequency	frequency	NN
cord-022594-fx044gcd	637	22	and	and	CC
cord-022594-fx044gcd	637	23	severity	severity	NN
cord-022594-fx044gcd	637	24	of	of	IN
cord-022594-fx044gcd	637	25	relapses	relapse	NNS
cord-022594-fx044gcd	637	26	,	,	,
cord-022594-fx044gcd	637	27	preventing	prevent	VBG
cord-022594-fx044gcd	637	28	the	the	DT
cord-022594-fx044gcd	637	29	chronic	chronic	JJ
cord-022594-fx044gcd	637	30	progressive	progressive	JJ
cord-022594-fx044gcd	637	31	phase	phase	NN
cord-022594-fx044gcd	637	32	,	,	,
cord-022594-fx044gcd	637	33	and	and	CC
cord-022594-fx044gcd	637	34	slowing	slow	VBG
cord-022594-fx044gcd	637	35	the	the	DT
cord-022594-fx044gcd	637	36	progression	progression	NN
cord-022594-fx044gcd	637	37	of	of	IN
cord-022594-fx044gcd	637	38	disability	disability	NN
cord-022594-fx044gcd	637	39	)	)	-RRB-
cord-022594-fx044gcd	637	40	.	.	.
cord-022594-fx044gcd	638	1	The	the	DT
cord-022594-fx044gcd	638	2	disease	disease	NN
cord-022594-fx044gcd	638	3	activity	activity	NN
cord-022594-fx044gcd	638	4	seen	see	VBN
cord-022594-fx044gcd	638	5	on	on	IN
cord-022594-fx044gcd	638	6	MRI	MRI	NNP
cord-022594-fx044gcd	638	7	is	be	VBZ
cord-022594-fx044gcd	638	8	often	often	RB
cord-022594-fx044gcd	638	9	used	use	VBN
cord-022594-fx044gcd	638	10	as	as	IN
cord-022594-fx044gcd	638	11	a	a	DT
cord-022594-fx044gcd	638	12	secondary	secondary	JJ
cord-022594-fx044gcd	638	13	outcome	outcome	NN
cord-022594-fx044gcd	638	14	,	,	,
cord-022594-fx044gcd	638	15	although	although	IN
cord-022594-fx044gcd	638	16	MRI	MRI	NNP
cord-022594-fx044gcd	638	17	measures	measure	NNS
cord-022594-fx044gcd	638	18	currently	currently	RB
cord-022594-fx044gcd	638	19	correlate	correlate	VBP
cord-022594-fx044gcd	638	20	imperfectly	imperfectly	RB
cord-022594-fx044gcd	638	21	with	with	IN
cord-022594-fx044gcd	638	22	clinical	clinical	JJ
cord-022594-fx044gcd	638	23	outcome	outcome	NN
cord-022594-fx044gcd	638	24	.	.	.
cord-022594-fx044gcd	639	1	Knowledge	knowledge	NN
cord-022594-fx044gcd	639	2	on	on	IN
cord-022594-fx044gcd	639	3	altering	alter	VBG
cord-022594-fx044gcd	639	4	the	the	DT
cord-022594-fx044gcd	639	5	course	course	NN
cord-022594-fx044gcd	639	6	of	of	IN
cord-022594-fx044gcd	639	7	MS	MS	NNP
cord-022594-fx044gcd	639	8	is	be	VBZ
cord-022594-fx044gcd	639	9	largely	largely	RB
cord-022594-fx044gcd	639	10	restricted	restrict	VBN
cord-022594-fx044gcd	639	11	to	to	IN
cord-022594-fx044gcd	639	12	three	three	CD
cord-022594-fx044gcd	639	13	patient	patient	JJ
cord-022594-fx044gcd	639	14	groups	group	NNS
cord-022594-fx044gcd	639	15	,	,	,
cord-022594-fx044gcd	639	16	those	those	DT
cord-022594-fx044gcd	639	17	with	with	IN
cord-022594-fx044gcd	639	18	clinically	clinically	RB
cord-022594-fx044gcd	639	19	isolated	isolate	VBN
cord-022594-fx044gcd	639	20	syndromes	syndrome	NNS
cord-022594-fx044gcd	639	21	,	,	,
cord-022594-fx044gcd	639	22	those	those	DT
cord-022594-fx044gcd	639	23	with	with	IN
cord-022594-fx044gcd	639	24	RRMS	RRMS	NNP
cord-022594-fx044gcd	639	25	,	,	,
cord-022594-fx044gcd	639	26	and	and	CC
cord-022594-fx044gcd	639	27	those	those	DT
cord-022594-fx044gcd	639	28	with	with	IN
cord-022594-fx044gcd	639	29	secondary	secondary	JJ
cord-022594-fx044gcd	639	30	progressive	progressive	JJ
cord-022594-fx044gcd	639	31	MS	MS	NNP
cord-022594-fx044gcd	639	32	.	.	.
cord-022594-fx044gcd	640	1	Before	before	IN
cord-022594-fx044gcd	640	2	we	-PRON-	PRP
cord-022594-fx044gcd	640	3	discuss	discuss	VBP
cord-022594-fx044gcd	640	4	the	the	DT
cord-022594-fx044gcd	640	5	known	know	VBN
cord-022594-fx044gcd	640	6	data	datum	NNS
cord-022594-fx044gcd	640	7	in	in	IN
cord-022594-fx044gcd	640	8	each	each	DT
cord-022594-fx044gcd	640	9	of	of	IN
cord-022594-fx044gcd	640	10	these	these	DT
cord-022594-fx044gcd	640	11	demyelinating	demyelinate	VBG
cord-022594-fx044gcd	640	12	disease	disease	NN
cord-022594-fx044gcd	640	13	categories	category	NNS
cord-022594-fx044gcd	640	14	,	,	,
cord-022594-fx044gcd	640	15	it	-PRON-	PRP
cord-022594-fx044gcd	640	16	may	may	MD
cord-022594-fx044gcd	640	17	be	be	VB
cord-022594-fx044gcd	640	18	worth	worth	JJ
cord-022594-fx044gcd	640	19	while	while	IN
cord-022594-fx044gcd	640	20	to	to	TO
cord-022594-fx044gcd	640	21	review	review	VB
cord-022594-fx044gcd	640	22	the	the	DT
cord-022594-fx044gcd	640	23	use	use	NN
cord-022594-fx044gcd	640	24	of	of	IN
cord-022594-fx044gcd	640	25	the	the	DT
cord-022594-fx044gcd	640	26	most	most	RBS
cord-022594-fx044gcd	640	27	important	important	JJ
cord-022594-fx044gcd	640	28	evidence	evidence	NN
cord-022594-fx044gcd	640	29	-	-	HYPH
cord-022594-fx044gcd	640	30	based	base	VBN
cord-022594-fx044gcd	640	31	medicine	medicine	NN
cord-022594-fx044gcd	640	32	(	(	-LRB-
cord-022594-fx044gcd	640	33	EBM	EBM	NNP
cord-022594-fx044gcd	640	34	)	)	-RRB-
cord-022594-fx044gcd	640	35	statistics	statistic	NNS
cord-022594-fx044gcd	640	36	that	that	WDT
cord-022594-fx044gcd	640	37	are	be	VBP
cord-022594-fx044gcd	640	38	applied	apply	VBN
cord-022594-fx044gcd	640	39	to	to	TO
cord-022594-fx044gcd	640	40	measure	measure	VB
cord-022594-fx044gcd	640	41	the	the	DT
cord-022594-fx044gcd	640	42	magnitude	magnitude	NN
cord-022594-fx044gcd	640	43	of	of	IN
cord-022594-fx044gcd	640	44	treatment	treatment	NN
cord-022594-fx044gcd	640	45	effect	effect	NN
cord-022594-fx044gcd	640	46	.	.	.
cord-022594-fx044gcd	641	1	Relative	relative	JJ
cord-022594-fx044gcd	641	2	risk	risk	NN
cord-022594-fx044gcd	641	3	reduction	reduction	NN
cord-022594-fx044gcd	641	4	(	(	-LRB-
cord-022594-fx044gcd	641	5	RRR	RRR	NNP
cord-022594-fx044gcd	641	6	)	)	-RRB-
cord-022594-fx044gcd	641	7	is	be	VBZ
cord-022594-fx044gcd	641	8	the	the	DT
cord-022594-fx044gcd	641	9	metric	metric	JJ
cord-022594-fx044gcd	641	10	most	most	RBS
cord-022594-fx044gcd	641	11	commonly	commonly	RB
cord-022594-fx044gcd	641	12	cited	cite	VBN
cord-022594-fx044gcd	641	13	in	in	IN
cord-022594-fx044gcd	641	14	publications	publication	NNS
cord-022594-fx044gcd	641	15	and	and	CC
cord-022594-fx044gcd	641	16	promotional	promotional	JJ
cord-022594-fx044gcd	641	17	materials	material	NNS
cord-022594-fx044gcd	641	18	about	about	IN
cord-022594-fx044gcd	641	19	clinical	clinical	JJ
cord-022594-fx044gcd	641	20	trials	trial	NNS
cord-022594-fx044gcd	641	21	.	.	.
cord-022594-fx044gcd	642	1	The	the	DT
cord-022594-fx044gcd	642	2	RRR	RRR	NNP
cord-022594-fx044gcd	642	3	is	be	VBZ
cord-022594-fx044gcd	642	4	the	the	DT
cord-022594-fx044gcd	642	5	degree	degree	NN
cord-022594-fx044gcd	642	6	that	that	IN
cord-022594-fx044gcd	642	7	the	the	DT
cord-022594-fx044gcd	642	8	treatment	treatment	NN
cord-022594-fx044gcd	642	9	reduced	reduce	VBD
cord-022594-fx044gcd	642	10	the	the	DT
cord-022594-fx044gcd	642	11	frequency	frequency	NN
cord-022594-fx044gcd	642	12	of	of	IN
cord-022594-fx044gcd	642	13	the	the	DT
cord-022594-fx044gcd	642	14	outcome	outcome	NN
cord-022594-fx044gcd	642	15	measure	measure	NN
cord-022594-fx044gcd	642	16	(	(	-LRB-
cord-022594-fx044gcd	642	17	experimental	experimental	JJ
cord-022594-fx044gcd	642	18	event	event	NN
cord-022594-fx044gcd	642	19	rate	rate	NN
cord-022594-fx044gcd	642	20	,	,	,
cord-022594-fx044gcd	642	21	e.g.	e.g.	RB
cord-022594-fx044gcd	642	22	,	,	,
cord-022594-fx044gcd	642	23	relapse	relapse	NN
cord-022594-fx044gcd	642	24	,	,	,
cord-022594-fx044gcd	642	25	progression	progression	NN
cord-022594-fx044gcd	642	26	)	)	-RRB-
cord-022594-fx044gcd	642	27	compared	compare	VBN
cord-022594-fx044gcd	642	28	with	with	IN
cord-022594-fx044gcd	642	29	the	the	DT
cord-022594-fx044gcd	642	30	control	control	NN
cord-022594-fx044gcd	642	31	treatment	treatment	NN
cord-022594-fx044gcd	642	32	(	(	-LRB-
cord-022594-fx044gcd	642	33	control	control	NN
cord-022594-fx044gcd	642	34	event	event	NN
cord-022594-fx044gcd	642	35	rate	rate	NN
cord-022594-fx044gcd	642	36	)	)	-RRB-
cord-022594-fx044gcd	642	37	.	.	.
cord-022594-fx044gcd	643	1	The	the	DT
cord-022594-fx044gcd	643	2	RRR	RRR	NNP
cord-022594-fx044gcd	643	3	is	be	VBZ
cord-022594-fx044gcd	643	4	a	a	DT
cord-022594-fx044gcd	643	5	ratio	ratio	NN
cord-022594-fx044gcd	643	6	,	,	,
cord-022594-fx044gcd	643	7	not	not	RB
cord-022594-fx044gcd	643	8	an	an	DT
cord-022594-fx044gcd	643	9	absolute	absolute	JJ
cord-022594-fx044gcd	643	10	number	number	NN
cord-022594-fx044gcd	643	11	,	,	,
cord-022594-fx044gcd	643	12	and	and	CC
cord-022594-fx044gcd	643	13	is	be	VBZ
cord-022594-fx044gcd	643	14	calculated	calculate	VBN
cord-022594-fx044gcd	643	15	as	as	IN
cord-022594-fx044gcd	643	16	follows	follow	VBZ
cord-022594-fx044gcd	643	17	:	:	:
cord-022594-fx044gcd	644	1	RRR	RRR	NNP
cord-022594-fx044gcd	644	2	¼	¼	NNP
cord-022594-fx044gcd	644	3	ðControl	ðControl	NNP
cord-022594-fx044gcd	644	4	event	event	NN
cord-022594-fx044gcd	644	5	rate	rate	NN
cord-022594-fx044gcd	644	6	À	à	NN
cord-022594-fx044gcd	644	7	experimental	experimental	JJ
cord-022594-fx044gcd	644	8	event	event	NN
cord-022594-fx044gcd	644	9	rateÞ=	rateÞ=	NNP
cord-022594-fx044gcd	644	10	control	control	NN
cord-022594-fx044gcd	644	11	event	event	NN
cord-022594-fx044gcd	644	12	rate	rate	NN
cord-022594-fx044gcd	645	1	If	if	IN
cord-022594-fx044gcd	645	2	the	the	DT
cord-022594-fx044gcd	645	3	control	control	NN
cord-022594-fx044gcd	645	4	event	event	NN
cord-022594-fx044gcd	645	5	rate	rate	NN
cord-022594-fx044gcd	645	6	is	be	VBZ
cord-022594-fx044gcd	645	7	low	low	JJ
cord-022594-fx044gcd	645	8	(	(	-LRB-
cord-022594-fx044gcd	645	9	making	make	VBG
cord-022594-fx044gcd	645	10	the	the	DT
cord-022594-fx044gcd	645	11	denominator	denominator	NN
cord-022594-fx044gcd	645	12	smaller	smaller	RBR
cord-022594-fx044gcd	645	13	)	)	-RRB-
cord-022594-fx044gcd	645	14	,	,	,
cord-022594-fx044gcd	645	15	it	-PRON-	PRP
cord-022594-fx044gcd	645	16	will	will	MD
cord-022594-fx044gcd	645	17	obviously	obviously	RB
cord-022594-fx044gcd	645	18	inflate	inflate	VB
cord-022594-fx044gcd	645	19	the	the	DT
cord-022594-fx044gcd	645	20	RRR	RRR	NNP
cord-022594-fx044gcd	645	21	.	.	.
cord-022594-fx044gcd	646	1	An	an	DT
cord-022594-fx044gcd	646	2	"	"	``
cord-022594-fx044gcd	646	3	impressive	impressive	JJ
cord-022594-fx044gcd	646	4	"	"	''
cord-022594-fx044gcd	646	5	50	50	CD
cord-022594-fx044gcd	646	6	%	%	NN
cord-022594-fx044gcd	646	7	RRR	RRR	NNP
cord-022594-fx044gcd	646	8	may	may	MD
cord-022594-fx044gcd	646	9	have	have	VB
cord-022594-fx044gcd	646	10	a	a	DT
cord-022594-fx044gcd	646	11	low	low	JJ
cord-022594-fx044gcd	646	12	biological	biological	JJ
cord-022594-fx044gcd	646	13	significance	significance	NN
cord-022594-fx044gcd	646	14	if	if	IN
cord-022594-fx044gcd	646	15	the	the	DT
cord-022594-fx044gcd	646	16	outcome	outcome	NN
cord-022594-fx044gcd	646	17	occurs	occur	VBZ
cord-022594-fx044gcd	646	18	infrequently	infrequently	RB
cord-022594-fx044gcd	646	19	.	.	.
cord-022594-fx044gcd	647	1	Therefore	therefore	RB
cord-022594-fx044gcd	647	2	,	,	,
cord-022594-fx044gcd	647	3	the	the	DT
cord-022594-fx044gcd	647	4	absolute	absolute	JJ
cord-022594-fx044gcd	647	5	risk	risk	NN
cord-022594-fx044gcd	647	6	reduction	reduction	NN
cord-022594-fx044gcd	647	7	(	(	-LRB-
cord-022594-fx044gcd	647	8	ARR	arr	NN
cord-022594-fx044gcd	647	9	)	)	-RRB-
cord-022594-fx044gcd	647	10	should	should	MD
cord-022594-fx044gcd	647	11	be	be	VB
cord-022594-fx044gcd	647	12	calculated	calculate	VBN
cord-022594-fx044gcd	647	13	as	as	IN
cord-022594-fx044gcd	647	14	this	this	DT
cord-022594-fx044gcd	647	15	corrects	correct	VBZ
cord-022594-fx044gcd	647	16	for	for	IN
cord-022594-fx044gcd	647	17	the	the	DT
cord-022594-fx044gcd	647	18	frequency	frequency	NN
cord-022594-fx044gcd	647	19	of	of	IN
cord-022594-fx044gcd	647	20	the	the	DT
cord-022594-fx044gcd	647	21	outcome	outcome	NN
cord-022594-fx044gcd	647	22	.	.	.
cord-022594-fx044gcd	648	1	For	for	IN
cord-022594-fx044gcd	648	2	most	most	JJS
cord-022594-fx044gcd	648	3	of	of	IN
cord-022594-fx044gcd	648	4	the	the	DT
cord-022594-fx044gcd	648	5	approved	approve	VBN
cord-022594-fx044gcd	648	6	MS	MS	NNP
cord-022594-fx044gcd	648	7	agents	agent	NNS
cord-022594-fx044gcd	648	8	,	,	,
cord-022594-fx044gcd	648	9	the	the	DT
cord-022594-fx044gcd	648	10	calculated	calculate	VBN
cord-022594-fx044gcd	648	11	ARR	arr	NN
cord-022594-fx044gcd	648	12	is	be	VBZ
cord-022594-fx044gcd	648	13	considerably	considerably	RB
cord-022594-fx044gcd	648	14	less	less	JJR
cord-022594-fx044gcd	648	15	than	than	IN
cord-022594-fx044gcd	648	16	RRR	RRR	NNP
cord-022594-fx044gcd	648	17	.	.	.
cord-022594-fx044gcd	649	1	This	this	DT
cord-022594-fx044gcd	649	2	metric	metric	NN
cord-022594-fx044gcd	649	3	is	be	VBZ
cord-022594-fx044gcd	649	4	usually	usually	RB
cord-022594-fx044gcd	649	5	not	not	RB
cord-022594-fx044gcd	649	6	cited	cite	VBN
cord-022594-fx044gcd	649	7	in	in	IN
cord-022594-fx044gcd	649	8	reports	report	NNS
cord-022594-fx044gcd	649	9	of	of	IN
cord-022594-fx044gcd	649	10	clinical	clinical	JJ
cord-022594-fx044gcd	649	11	trials	trial	NNS
cord-022594-fx044gcd	649	12	of	of	IN
cord-022594-fx044gcd	649	13	disease	disease	NN
cord-022594-fx044gcd	649	14	-	-	HYPH
cord-022594-fx044gcd	649	15	modifying	modify	VBG
cord-022594-fx044gcd	649	16	agents	agent	NNS
cord-022594-fx044gcd	649	17	.	.	.
cord-022594-fx044gcd	650	1	To	to	TO
cord-022594-fx044gcd	650	2	calculate	calculate	VB
cord-022594-fx044gcd	650	3	risk	risk	NN
cord-022594-fx044gcd	650	4	reduction	reduction	NN
cord-022594-fx044gcd	650	5	,	,	,
cord-022594-fx044gcd	650	6	one	one	PRP
cord-022594-fx044gcd	650	7	must	must	MD
cord-022594-fx044gcd	650	8	have	have	VB
cord-022594-fx044gcd	650	9	access	access	NN
cord-022594-fx044gcd	650	10	to	to	IN
cord-022594-fx044gcd	650	11	the	the	DT
cord-022594-fx044gcd	650	12	data	datum	NNS
cord-022594-fx044gcd	650	13	citing	cite	VBG
cord-022594-fx044gcd	650	14	comparisons	comparison	NNS
cord-022594-fx044gcd	650	15	of	of	IN
cord-022594-fx044gcd	650	16	proportions	proportion	NNS
cord-022594-fx044gcd	650	17	(	(	-LRB-
cord-022594-fx044gcd	650	18	ratios	ratio	NNS
cord-022594-fx044gcd	650	19	)	)	-RRB-
cord-022594-fx044gcd	650	20	,	,	,
cord-022594-fx044gcd	650	21	and	and	CC
cord-022594-fx044gcd	650	22	this	this	DT
cord-022594-fx044gcd	650	23	is	be	VBZ
cord-022594-fx044gcd	650	24	not	not	RB
cord-022594-fx044gcd	650	25	always	always	RB
cord-022594-fx044gcd	650	26	immediately	immediately	RB
cord-022594-fx044gcd	650	27	available	available	JJ
cord-022594-fx044gcd	650	28	in	in	IN
cord-022594-fx044gcd	650	29	publications	publication	NNS
cord-022594-fx044gcd	650	30	.	.	.
cord-022594-fx044gcd	651	1	Another	another	DT
cord-022594-fx044gcd	651	2	useful	useful	JJ
cord-022594-fx044gcd	651	3	measure	measure	NN
cord-022594-fx044gcd	651	4	of	of	IN
cord-022594-fx044gcd	651	5	treatment	treatment	NN
cord-022594-fx044gcd	651	6	effect	effect	NN
cord-022594-fx044gcd	651	7	is	be	VBZ
cord-022594-fx044gcd	651	8	the	the	DT
cord-022594-fx044gcd	651	9	"	"	``
cord-022594-fx044gcd	651	10	number	number	NN
cord-022594-fx044gcd	651	11	needed	need	VBN
cord-022594-fx044gcd	651	12	to	to	TO
cord-022594-fx044gcd	651	13	treat	treat	VB
cord-022594-fx044gcd	651	14	"	"	''
cord-022594-fx044gcd	651	15	(	(	-LRB-
cord-022594-fx044gcd	651	16	NNT	NNT	NNP
cord-022594-fx044gcd	651	17	)	)	-RRB-
cord-022594-fx044gcd	651	18	.	.	.
cord-022594-fx044gcd	652	1	It	-PRON-	PRP
cord-022594-fx044gcd	652	2	is	be	VBZ
cord-022594-fx044gcd	652	3	calculated	calculate	VBN
cord-022594-fx044gcd	652	4	as	as	IN
cord-022594-fx044gcd	652	5	the	the	DT
cord-022594-fx044gcd	652	6	inverse	inverse	NN
cord-022594-fx044gcd	652	7	of	of	IN
cord-022594-fx044gcd	652	8	the	the	DT
cord-022594-fx044gcd	652	9	ARR	arr	NN
cord-022594-fx044gcd	652	10	:	:	:
cord-022594-fx044gcd	652	11	Overall	overall	RB
cord-022594-fx044gcd	652	12	,	,	,
cord-022594-fx044gcd	652	13	the	the	DT
cord-022594-fx044gcd	652	14	NNTs	nnts	NN
cord-022594-fx044gcd	652	15	for	for	IN
cord-022594-fx044gcd	652	16	the	the	DT
cord-022594-fx044gcd	652	17	disease	disease	NN
cord-022594-fx044gcd	652	18	-	-	HYPH
cord-022594-fx044gcd	652	19	modifying	modify	VBG
cord-022594-fx044gcd	652	20	agents	agent	NNS
cord-022594-fx044gcd	652	21	in	in	IN
cord-022594-fx044gcd	652	22	MS	MS	NNP
cord-022594-fx044gcd	652	23	are	be	VBP
cord-022594-fx044gcd	652	24	in	in	IN
cord-022594-fx044gcd	652	25	the	the	DT
cord-022594-fx044gcd	652	26	7	7	CD
cord-022594-fx044gcd	652	27	to	to	TO
cord-022594-fx044gcd	652	28	14	14	CD
cord-022594-fx044gcd	652	29	range	range	NN
cord-022594-fx044gcd	652	30	for	for	IN
cord-022594-fx044gcd	652	31	treatment	treatment	NN
cord-022594-fx044gcd	652	32	periods	period	NNS
cord-022594-fx044gcd	652	33	of	of	IN
cord-022594-fx044gcd	652	34	2	2	CD
cord-022594-fx044gcd	652	35	to	to	TO
cord-022594-fx044gcd	652	36	3	3	CD
cord-022594-fx044gcd	652	37	years	year	NNS
cord-022594-fx044gcd	652	38	.	.	.
cord-022594-fx044gcd	653	1	However	however	RB
cord-022594-fx044gcd	653	2	,	,	,
cord-022594-fx044gcd	653	3	these	these	DT
cord-022594-fx044gcd	653	4	NNTs	nnt	NNS
cord-022594-fx044gcd	653	5	are	be	VBP
cord-022594-fx044gcd	653	6	for	for	IN
cord-022594-fx044gcd	653	7	outcomes	outcome	NNS
cord-022594-fx044gcd	653	8	that	that	WDT
cord-022594-fx044gcd	653	9	have	have	VBP
cord-022594-fx044gcd	653	10	limited	limit	VBN
cord-022594-fx044gcd	653	11	predictive	predictive	JJ
cord-022594-fx044gcd	653	12	value	value	NN
cord-022594-fx044gcd	653	13	for	for	IN
cord-022594-fx044gcd	653	14	long	long	JJ
cord-022594-fx044gcd	653	15	-	-	HYPH
cord-022594-fx044gcd	653	16	term	term	NN
cord-022594-fx044gcd	653	17	outcomes	outcome	NNS
cord-022594-fx044gcd	653	18	(	(	-LRB-
cord-022594-fx044gcd	653	19	e.g.	e.g.	RB
cord-022594-fx044gcd	653	20	,	,	,
cord-022594-fx044gcd	653	21	relapse	relapse	NN
cord-022594-fx044gcd	653	22	behavior	behavior	NN
cord-022594-fx044gcd	653	23	does	do	VBZ
cord-022594-fx044gcd	653	24	not	not	RB
cord-022594-fx044gcd	653	25	precisely	precisely	RB
cord-022594-fx044gcd	653	26	predict	predict	VB
cord-022594-fx044gcd	653	27	long	long	JJ
cord-022594-fx044gcd	653	28	-	-	HYPH
cord-022594-fx044gcd	653	29	term	term	NN
cord-022594-fx044gcd	653	30	disability	disability	NN
cord-022594-fx044gcd	653	31	)	)	-RRB-
cord-022594-fx044gcd	653	32	and	and	CC
cord-022594-fx044gcd	653	33	the	the	DT
cord-022594-fx044gcd	653	34	agents	agent	NNS
cord-022594-fx044gcd	653	35	are	be	VBP
cord-022594-fx044gcd	653	36	expensive	expensive	JJ
cord-022594-fx044gcd	653	37	,	,	,
cord-022594-fx044gcd	653	38	inconvenient	inconvenient	JJ
cord-022594-fx044gcd	653	39	to	to	TO
cord-022594-fx044gcd	653	40	use	use	VB
cord-022594-fx044gcd	653	41	,	,	,
cord-022594-fx044gcd	653	42	and	and	CC
cord-022594-fx044gcd	653	43	not	not	RB
cord-022594-fx044gcd	653	44	without	without	IN
cord-022594-fx044gcd	653	45	risk	risk	NN
cord-022594-fx044gcd	653	46	.	.	.
cord-022594-fx044gcd	654	1	We	-PRON-	PRP
cord-022594-fx044gcd	654	2	must	must	MD
cord-022594-fx044gcd	654	3	also	also	RB
cord-022594-fx044gcd	654	4	remember	remember	VB
cord-022594-fx044gcd	654	5	that	that	IN
cord-022594-fx044gcd	654	6	clinical	clinical	JJ
cord-022594-fx044gcd	654	7	trials	trial	NNS
cord-022594-fx044gcd	654	8	typically	typically	RB
cord-022594-fx044gcd	654	9	enroll	enroll	VBP
cord-022594-fx044gcd	654	10	patients	patient	NNS
cord-022594-fx044gcd	654	11	with	with	IN
cord-022594-fx044gcd	654	12	very	very	RB
cord-022594-fx044gcd	654	13	restricted	restricted	JJ
cord-022594-fx044gcd	654	14	eligibility	eligibility	NN
cord-022594-fx044gcd	654	15	criteria	criterion	NNS
cord-022594-fx044gcd	654	16	(	(	-LRB-
cord-022594-fx044gcd	654	17	often	often	RB
cord-022594-fx044gcd	654	18	a	a	DT
cord-022594-fx044gcd	654	19	history	history	NN
cord-022594-fx044gcd	654	20	of	of	IN
cord-022594-fx044gcd	654	21	considerable	considerable	JJ
cord-022594-fx044gcd	654	22	recent	recent	JJ
cord-022594-fx044gcd	654	23	disease	disease	NN
cord-022594-fx044gcd	654	24	activity	activity	NN
cord-022594-fx044gcd	654	25	or	or	CC
cord-022594-fx044gcd	654	26	progression	progression	NN
cord-022594-fx044gcd	654	27	)	)	-RRB-
cord-022594-fx044gcd	654	28	,	,	,
cord-022594-fx044gcd	654	29	and	and	CC
cord-022594-fx044gcd	654	30	considerable	considerable	JJ
cord-022594-fx044gcd	654	31	efforts	effort	NNS
cord-022594-fx044gcd	654	32	are	be	VBP
cord-022594-fx044gcd	654	33	in	in	IN
cord-022594-fx044gcd	654	34	place	place	NN
cord-022594-fx044gcd	654	35	in	in	IN
cord-022594-fx044gcd	654	36	trials	trial	NNS
cord-022594-fx044gcd	654	37	to	to	TO
cord-022594-fx044gcd	654	38	optimize	optimize	VB
cord-022594-fx044gcd	654	39	compliance	compliance	NN
cord-022594-fx044gcd	654	40	with	with	IN
cord-022594-fx044gcd	654	41	the	the	DT
cord-022594-fx044gcd	654	42	treatment	treatment	NN
cord-022594-fx044gcd	654	43	plan	plan	NN
cord-022594-fx044gcd	654	44	.	.	.
cord-022594-fx044gcd	655	1	As	as	IN
cord-022594-fx044gcd	655	2	such	such	JJ
cord-022594-fx044gcd	655	3	,	,	,
cord-022594-fx044gcd	655	4	the	the	DT
cord-022594-fx044gcd	655	5	NNT	NNT	NNP
cord-022594-fx044gcd	655	6	experienced	experience	VBD
cord-022594-fx044gcd	655	7	in	in	IN
cord-022594-fx044gcd	655	8	a	a	DT
cord-022594-fx044gcd	655	9	practice	practice	NN
cord-022594-fx044gcd	655	10	setting	set	VBG
cord-022594-fx044gcd	655	11	(	(	-LRB-
cord-022594-fx044gcd	655	12	effectiveness	effectiveness	NN
cord-022594-fx044gcd	655	13	)	)	-RRB-
cord-022594-fx044gcd	655	14	may	may	MD
cord-022594-fx044gcd	655	15	considerably	considerably	RB
cord-022594-fx044gcd	655	16	exceed	exceed	VB
cord-022594-fx044gcd	655	17	what	what	WP
cord-022594-fx044gcd	655	18	was	be	VBD
cord-022594-fx044gcd	655	19	reported	report	VBN
cord-022594-fx044gcd	655	20	in	in	IN
cord-022594-fx044gcd	655	21	the	the	DT
cord-022594-fx044gcd	655	22	trial	trial	NN
cord-022594-fx044gcd	655	23	setting	setting	NN
cord-022594-fx044gcd	655	24	.	.	.
cord-022594-fx044gcd	656	1	Altering	alter	VBG
cord-022594-fx044gcd	656	2	the	the	DT
cord-022594-fx044gcd	656	3	Course	course	NN
cord-022594-fx044gcd	656	4	of	of	IN
cord-022594-fx044gcd	656	5	a	a	DT
cord-022594-fx044gcd	656	6	Clinically	clinically	RB
cord-022594-fx044gcd	656	7	Isolated	isolated	JJ
cord-022594-fx044gcd	656	8	Syndrome	syndrome	NN
cord-022594-fx044gcd	656	9	.	.	.
cord-022594-fx044gcd	657	1	When	when	WRB
cord-022594-fx044gcd	657	2	should	should	MD
cord-022594-fx044gcd	657	3	treatment	treatment	NN
cord-022594-fx044gcd	657	4	be	be	VB
cord-022594-fx044gcd	657	5	initiated	initiate	VBN
cord-022594-fx044gcd	657	6	in	in	IN
cord-022594-fx044gcd	657	7	patients	patient	NNS
cord-022594-fx044gcd	657	8	with	with	IN
cord-022594-fx044gcd	657	9	very	very	RB
cord-022594-fx044gcd	657	10	early	early	JJ
cord-022594-fx044gcd	657	11	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	657	12	disease	disease	NN
cord-022594-fx044gcd	657	13	?	?	.
cord-022594-fx044gcd	658	1	Two	two	CD
cord-022594-fx044gcd	658	2	recently	recently	RB
cord-022594-fx044gcd	658	3	published	publish	VBN
cord-022594-fx044gcd	658	4	multicenter	multicenter	JJ
cord-022594-fx044gcd	658	5	studies	study	NNS
cord-022594-fx044gcd	658	6	have	have	VBP
cord-022594-fx044gcd	658	7	addressed	address	VBN
cord-022594-fx044gcd	658	8	this	this	DT
cord-022594-fx044gcd	658	9	issue	issue	NN
cord-022594-fx044gcd	658	10	in	in	IN
cord-022594-fx044gcd	658	11	persons	person	NNS
cord-022594-fx044gcd	658	12	at	at	IN
cord-022594-fx044gcd	658	13	high	high	JJ
cord-022594-fx044gcd	658	14	risk	risk	NN
cord-022594-fx044gcd	658	15	of	of	IN
cord-022594-fx044gcd	658	16	developing	develop	VBG
cord-022594-fx044gcd	658	17	MS	MS	NNP
cord-022594-fx044gcd	658	18	.	.	.
cord-022594-fx044gcd	659	1	In	in	IN
cord-022594-fx044gcd	659	2	the	the	DT
cord-022594-fx044gcd	659	3	CHAMPS	CHAMPS	NNP
cord-022594-fx044gcd	659	4	study	study	NN
cord-022594-fx044gcd	659	5	,	,	,
cord-022594-fx044gcd	659	6	61	61	CD
cord-022594-fx044gcd	659	7	383	383	CD
cord-022594-fx044gcd	659	8	patients	patient	NNS
cord-022594-fx044gcd	659	9	with	with	IN
cord-022594-fx044gcd	659	10	their	-PRON-	PRP$
cord-022594-fx044gcd	659	11	first	first	JJ
cord-022594-fx044gcd	659	12	episode	episode	NN
cord-022594-fx044gcd	659	13	of	of	IN
cord-022594-fx044gcd	659	14	presumed	presumed	JJ
cord-022594-fx044gcd	659	15	demyelinating	demyelinating	NN
cord-022594-fx044gcd	659	16	disease	disease	NN
cord-022594-fx044gcd	659	17	(	(	-LRB-
cord-022594-fx044gcd	659	18	"	"	``
cord-022594-fx044gcd	659	19	clinically	clinically	RB
cord-022594-fx044gcd	659	20	isolated	isolated	JJ
cord-022594-fx044gcd	659	21	syndrome	syndrome	NN
cord-022594-fx044gcd	659	22	"	"	''
cord-022594-fx044gcd	659	23	)	)	-RRB-
cord-022594-fx044gcd	659	24	in	in	IN
cord-022594-fx044gcd	659	25	the	the	DT
cord-022594-fx044gcd	659	26	setting	setting	NN
cord-022594-fx044gcd	659	27	of	of	IN
cord-022594-fx044gcd	659	28	an	an	DT
cord-022594-fx044gcd	659	29	abnormal	abnormal	JJ
cord-022594-fx044gcd	659	30	,	,	,
cord-022594-fx044gcd	659	31	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	659	32	baseline	baseline	JJ
cord-022594-fx044gcd	659	33	cranial	cranial	JJ
cord-022594-fx044gcd	659	34	MRI	MRI	NNP
cord-022594-fx044gcd	659	35	scan	scan	NN
cord-022594-fx044gcd	659	36	,	,	,
cord-022594-fx044gcd	659	37	were	be	VBD
cord-022594-fx044gcd	659	38	randomized	randomize	VBN
cord-022594-fx044gcd	659	39	to	to	TO
cord-022594-fx044gcd	659	40	receive	receive	VB
cord-022594-fx044gcd	659	41	either	either	DT
cord-022594-fx044gcd	659	42	weekly	weekly	JJ
cord-022594-fx044gcd	659	43	interferon	interferon	NN
cord-022594-fx044gcd	659	44	-	-	HYPH
cord-022594-fx044gcd	659	45	b	b	NN
cord-022594-fx044gcd	659	46	1a	1a	CD
cord-022594-fx044gcd	659	47	30	30	CD
cord-022594-fx044gcd	659	48	mg	mg	NN
cord-022594-fx044gcd	659	49	IM	IM	NNP
cord-022594-fx044gcd	659	50	or	or	CC
cord-022594-fx044gcd	659	51	placebo	placebo	NN
cord-022594-fx044gcd	659	52	after	after	IN
cord-022594-fx044gcd	659	53	an	an	DT
cord-022594-fx044gcd	659	54	initial	initial	JJ
cord-022594-fx044gcd	659	55	course	course	NN
cord-022594-fx044gcd	659	56	of	of	IN
cord-022594-fx044gcd	659	57	steroid	steroid	NN
cord-022594-fx044gcd	659	58	therapy	therapy	NN
cord-022594-fx044gcd	659	59	.	.	.
cord-022594-fx044gcd	660	1	This	this	DT
cord-022594-fx044gcd	660	2	study	study	NN
cord-022594-fx044gcd	660	3	was	be	VBD
cord-022594-fx044gcd	660	4	terminated	terminate	VBN
cord-022594-fx044gcd	660	5	early	early	RB
cord-022594-fx044gcd	660	6	when	when	WRB
cord-022594-fx044gcd	660	7	the	the	DT
cord-022594-fx044gcd	660	8	primary	primary	JJ
cord-022594-fx044gcd	660	9	outcome	outcome	NN
cord-022594-fx044gcd	660	10	measure	measure	NN
cord-022594-fx044gcd	660	11	of	of	IN
cord-022594-fx044gcd	660	12	conversion	conversion	NN
cord-022594-fx044gcd	660	13	to	to	IN
cord-022594-fx044gcd	660	14	"	"	``
cord-022594-fx044gcd	660	15	clinically	clinically	RB
cord-022594-fx044gcd	660	16	definite	definite	JJ
cord-022594-fx044gcd	660	17	MS	ms	NN
cord-022594-fx044gcd	660	18	"	"	''
cord-022594-fx044gcd	660	19	(	(	-LRB-
cord-022594-fx044gcd	660	20	CDMS	CDMS	NNP
cord-022594-fx044gcd	660	21	)	)	-RRB-
cord-022594-fx044gcd	660	22	status	status	NN
cord-022594-fx044gcd	660	23	was	be	VBD
cord-022594-fx044gcd	660	24	reached	reach	VBN
cord-022594-fx044gcd	660	25	in	in	IN
cord-022594-fx044gcd	660	26	a	a	DT
cord-022594-fx044gcd	660	27	greater	great	JJR
cord-022594-fx044gcd	660	28	number	number	NN
cord-022594-fx044gcd	660	29	of	of	IN
cord-022594-fx044gcd	660	30	placebo	placebo	NN
cord-022594-fx044gcd	660	31	-	-	HYPH
cord-022594-fx044gcd	660	32	treated	treat	VBN
cord-022594-fx044gcd	660	33	patients	patient	NNS
cord-022594-fx044gcd	660	34	.	.	.
cord-022594-fx044gcd	661	1	These	these	DT
cord-022594-fx044gcd	661	2	findings	finding	NNS
cord-022594-fx044gcd	661	3	were	be	VBD
cord-022594-fx044gcd	661	4	not	not	RB
cord-022594-fx044gcd	661	5	unexpected	unexpected	JJ
cord-022594-fx044gcd	661	6	given	give	VBN
cord-022594-fx044gcd	661	7	the	the	DT
cord-022594-fx044gcd	661	8	known	know	VBN
cord-022594-fx044gcd	661	9	effect	effect	NN
cord-022594-fx044gcd	661	10	of	of	IN
cord-022594-fx044gcd	661	11	interferons	interferon	NNS
cord-022594-fx044gcd	661	12	on	on	IN
cord-022594-fx044gcd	661	13	reducing	reduce	VBG
cord-022594-fx044gcd	661	14	relapse	relapse	NN
cord-022594-fx044gcd	661	15	rate	rate	NN
cord-022594-fx044gcd	661	16	but	but	CC
cord-022594-fx044gcd	661	17	do	do	VBP
cord-022594-fx044gcd	661	18	provide	provide	VB
cord-022594-fx044gcd	661	19	some	some	DT
cord-022594-fx044gcd	661	20	support	support	NN
cord-022594-fx044gcd	661	21	for	for	IN
cord-022594-fx044gcd	661	22	early	early	JJ
cord-022594-fx044gcd	661	23	treatment	treatment	NN
cord-022594-fx044gcd	661	24	.	.	.
cord-022594-fx044gcd	662	1	The	the	DT
cord-022594-fx044gcd	662	2	duration	duration	NN
cord-022594-fx044gcd	662	3	of	of	IN
cord-022594-fx044gcd	662	4	follow	follow	NN
cord-022594-fx044gcd	662	5	-	-	HYPH
cord-022594-fx044gcd	662	6	up	up	NN
cord-022594-fx044gcd	662	7	in	in	IN
cord-022594-fx044gcd	662	8	this	this	DT
cord-022594-fx044gcd	662	9	study	study	NN
cord-022594-fx044gcd	662	10	(	(	-LRB-
cord-022594-fx044gcd	662	11	71	71	CD
cord-022594-fx044gcd	662	12	%	%	NN
cord-022594-fx044gcd	662	13	1	1	CD
cord-022594-fx044gcd	662	14	year	year	NN
cord-022594-fx044gcd	662	15	,	,	,
cord-022594-fx044gcd	662	16	34	34	CD
cord-022594-fx044gcd	662	17	%	%	NN
cord-022594-fx044gcd	662	18	2	2	CD
cord-022594-fx044gcd	662	19	years	year	NNS
cord-022594-fx044gcd	662	20	,	,	,
cord-022594-fx044gcd	662	21	16	16	CD
cord-022594-fx044gcd	662	22	%	%	NN
cord-022594-fx044gcd	662	23	3	3	CD
cord-022594-fx044gcd	662	24	years	year	NNS
cord-022594-fx044gcd	662	25	)	)	-RRB-
cord-022594-fx044gcd	662	26	is	be	VBZ
cord-022594-fx044gcd	662	27	insufficient	insufficient	JJ
cord-022594-fx044gcd	662	28	to	to	TO
cord-022594-fx044gcd	662	29	determine	determine	VB
cord-022594-fx044gcd	662	30	long	long	JJ
cord-022594-fx044gcd	662	31	-	-	HYPH
cord-022594-fx044gcd	662	32	term	term	NN
cord-022594-fx044gcd	662	33	benefit	benefit	NN
cord-022594-fx044gcd	662	34	from	from	IN
cord-022594-fx044gcd	662	35	early	early	JJ
cord-022594-fx044gcd	662	36	intervention	intervention	NN
cord-022594-fx044gcd	662	37	,	,	,
cord-022594-fx044gcd	662	38	however	however	RB
cord-022594-fx044gcd	662	39	.	.	.
cord-022594-fx044gcd	663	1	It	-PRON-	PRP
cord-022594-fx044gcd	663	2	is	be	VBZ
cord-022594-fx044gcd	663	3	also	also	RB
cord-022594-fx044gcd	663	4	clear	clear	JJ
cord-022594-fx044gcd	663	5	that	that	IN
cord-022594-fx044gcd	663	6	the	the	DT
cord-022594-fx044gcd	663	7	treatment	treatment	NN
cord-022594-fx044gcd	663	8	is	be	VBZ
cord-022594-fx044gcd	663	9	only	only	RB
cord-022594-fx044gcd	663	10	partially	partially	RB
cord-022594-fx044gcd	663	11	effective	effective	JJ
cord-022594-fx044gcd	663	12	,	,	,
cord-022594-fx044gcd	663	13	as	as	IN
cord-022594-fx044gcd	663	14	50	50	CD
cord-022594-fx044gcd	663	15	%	%	NN
cord-022594-fx044gcd	663	16	of	of	IN
cord-022594-fx044gcd	663	17	interferon	interferon	NN
cord-022594-fx044gcd	663	18	(	(	-LRB-
cord-022594-fx044gcd	663	19	IFN)-treated	ifn)-treate	VBN
cord-022594-fx044gcd	663	20	patients	patient	NNS
cord-022594-fx044gcd	663	21	in	in	IN
cord-022594-fx044gcd	663	22	the	the	DT
cord-022594-fx044gcd	663	23	CHAMPS	CHAMPS	NNP
cord-022594-fx044gcd	663	24	trial	trial	NN
cord-022594-fx044gcd	663	25	had	have	VBD
cord-022594-fx044gcd	663	26	clinical	clinical	JJ
cord-022594-fx044gcd	663	27	or	or	CC
cord-022594-fx044gcd	663	28	MRI	MRI	NNP
cord-022594-fx044gcd	663	29	evidence	evidence	NN
cord-022594-fx044gcd	663	30	of	of	IN
cord-022594-fx044gcd	663	31	recurrent	recurrent	JJ
cord-022594-fx044gcd	663	32	disease	disease	NN
cord-022594-fx044gcd	663	33	within	within	IN
cord-022594-fx044gcd	663	34	18	18	CD
cord-022594-fx044gcd	663	35	months	month	NNS
cord-022594-fx044gcd	663	36	of	of	IN
cord-022594-fx044gcd	663	37	starting	start	VBG
cord-022594-fx044gcd	663	38	treatment	treatment	NN
cord-022594-fx044gcd	663	39	.	.	.
cord-022594-fx044gcd	664	1	62	62	CD
cord-022594-fx044gcd	665	1	The	the	DT
cord-022594-fx044gcd	665	2	analysis	analysis	NN
cord-022594-fx044gcd	665	3	of	of	IN
cord-022594-fx044gcd	665	4	treatment	treatment	NN
cord-022594-fx044gcd	665	5	effect	effect	NN
cord-022594-fx044gcd	665	6	related	relate	VBN
cord-022594-fx044gcd	665	7	to	to	IN
cord-022594-fx044gcd	665	8	the	the	DT
cord-022594-fx044gcd	665	9	CHAMPS	CHAMPS	NNP
cord-022594-fx044gcd	665	10	trial	trial	NN
cord-022594-fx044gcd	665	11	reveal	reveal	VBP
cord-022594-fx044gcd	665	12	a	a	DT
cord-022594-fx044gcd	665	13	RRR	RRR	NNP
cord-022594-fx044gcd	665	14	of	of	IN
cord-022594-fx044gcd	665	15	38	38	CD
cord-022594-fx044gcd	665	16	%	%	NN
cord-022594-fx044gcd	665	17	,	,	,
cord-022594-fx044gcd	665	18	an	an	DT
cord-022594-fx044gcd	665	19	ARR	arr	NN
cord-022594-fx044gcd	665	20	of	of	IN
cord-022594-fx044gcd	665	21	14.6	14.6	CD
cord-022594-fx044gcd	665	22	%	%	NN
cord-022594-fx044gcd	665	23	,	,	,
cord-022594-fx044gcd	665	24	and	and	CC
cord-022594-fx044gcd	665	25	an	an	DT
cord-022594-fx044gcd	665	26	NNT	nnt	NN
cord-022594-fx044gcd	665	27	of	of	IN
cord-022594-fx044gcd	665	28	7	7	CD
cord-022594-fx044gcd	665	29	patients	patient	NNS
cord-022594-fx044gcd	665	30	over	over	IN
cord-022594-fx044gcd	665	31	2	2	CD
cord-022594-fx044gcd	665	32	years	year	NNS
cord-022594-fx044gcd	665	33	to	to	TO
cord-022594-fx044gcd	665	34	prevent	prevent	VB
cord-022594-fx044gcd	665	35	one	one	CD
cord-022594-fx044gcd	665	36	conversion	conversion	NN
cord-022594-fx044gcd	665	37	to	to	IN
cord-022594-fx044gcd	665	38	"	"	``
cord-022594-fx044gcd	665	39	clinically	clinically	RB
cord-022594-fx044gcd	665	40	definite	definite	JJ
cord-022594-fx044gcd	665	41	MS	m	NNS
cord-022594-fx044gcd	665	42	.	.	.
cord-022594-fx044gcd	666	1	"	"	``
cord-022594-fx044gcd	666	2	In	in	IN
cord-022594-fx044gcd	666	3	a	a	DT
cord-022594-fx044gcd	666	4	second	second	JJ
cord-022594-fx044gcd	666	5	placebo	placebo	NN
cord-022594-fx044gcd	666	6	-	-	HYPH
cord-022594-fx044gcd	666	7	controlled	control	VBN
cord-022594-fx044gcd	666	8	study	study	NN
cord-022594-fx044gcd	666	9	of	of	IN
cord-022594-fx044gcd	666	10	309	309	CD
cord-022594-fx044gcd	666	11	patients	patient	NNS
cord-022594-fx044gcd	666	12	with	with	IN
cord-022594-fx044gcd	666	13	either	either	CC
cord-022594-fx044gcd	666	14	monosymptomatic	monosymptomatic	JJ
cord-022594-fx044gcd	666	15	(	(	-LRB-
cord-022594-fx044gcd	666	16	61	61	CD
cord-022594-fx044gcd	666	17	%	%	NN
cord-022594-fx044gcd	666	18	)	)	-RRB-
cord-022594-fx044gcd	666	19	or	or	CC
cord-022594-fx044gcd	666	20	multifocal	multifocal	JJ
cord-022594-fx044gcd	666	21	onset	onset	NN
cord-022594-fx044gcd	666	22	(	(	-LRB-
cord-022594-fx044gcd	666	23	39	39	CD
cord-022594-fx044gcd	666	24	%	%	NN
cord-022594-fx044gcd	666	25	)	)	-RRB-
cord-022594-fx044gcd	666	26	early	early	JJ
cord-022594-fx044gcd	666	27	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	666	28	disease	disease	NN
cord-022594-fx044gcd	666	29	,	,	,
cord-022594-fx044gcd	666	30	early	early	JJ
cord-022594-fx044gcd	666	31	treatment	treatment	NN
cord-022594-fx044gcd	666	32	with	with	IN
cord-022594-fx044gcd	666	33	interferon	interferon	NN
cord-022594-fx044gcd	666	34	-	-	HYPH
cord-022594-fx044gcd	666	35	b	b	NN
cord-022594-fx044gcd	666	36	1a	1a	NN
cord-022594-fx044gcd	666	37	in	in	IN
cord-022594-fx044gcd	666	38	an	an	DT
cord-022594-fx044gcd	666	39	unusually	unusually	RB
cord-022594-fx044gcd	666	40	low	low	JJ
cord-022594-fx044gcd	666	41	dose	dose	NN
cord-022594-fx044gcd	666	42	(	(	-LRB-
cord-022594-fx044gcd	666	43	22	22	CD
cord-022594-fx044gcd	666	44	mg	mg	NNS
cord-022594-fx044gcd	666	45	subcutaneously	subcutaneously	RB
cord-022594-fx044gcd	666	46	once	once	RB
cord-022594-fx044gcd	666	47	weekly	weekly	RB
cord-022594-fx044gcd	666	48	)	)	-RRB-
cord-022594-fx044gcd	666	49	,	,	,
cord-022594-fx044gcd	666	50	reduced	reduce	VBN
cord-022594-fx044gcd	666	51	conversion	conversion	NN
cord-022594-fx044gcd	666	52	to	to	IN
cord-022594-fx044gcd	666	53	CDMS	CDMS	NNP
cord-022594-fx044gcd	666	54	(	(	-LRB-
cord-022594-fx044gcd	666	55	34	34	CD
cord-022594-fx044gcd	666	56	%	%	NN
cord-022594-fx044gcd	666	57	versus	versus	IN
cord-022594-fx044gcd	666	58	45	45	CD
cord-022594-fx044gcd	666	59	%	%	NN
cord-022594-fx044gcd	666	60	)	)	-RRB-
cord-022594-fx044gcd	666	61	at	at	IN
cord-022594-fx044gcd	666	62	2	2	CD
cord-022594-fx044gcd	666	63	years	year	NNS
cord-022594-fx044gcd	666	64	.	.	.
cord-022594-fx044gcd	667	1	63	63	CD
cord-022594-fx044gcd	668	1	Again	again	RB
cord-022594-fx044gcd	668	2	,	,	,
cord-022594-fx044gcd	668	3	there	there	EX
cord-022594-fx044gcd	668	4	is	be	VBZ
cord-022594-fx044gcd	668	5	no	no	DT
cord-022594-fx044gcd	668	6	data	data	NN
cord-022594-fx044gcd	668	7	on	on	IN
cord-022594-fx044gcd	668	8	whether	whether	IN
cord-022594-fx044gcd	668	9	these	these	DT
cord-022594-fx044gcd	668	10	treatments	treatment	NNS
cord-022594-fx044gcd	668	11	offer	offer	VBP
cord-022594-fx044gcd	668	12	long	long	JJ
cord-022594-fx044gcd	668	13	-	-	HYPH
cord-022594-fx044gcd	668	14	term	term	NN
cord-022594-fx044gcd	668	15	benefit	benefit	NN
cord-022594-fx044gcd	668	16	.	.	.
cord-022594-fx044gcd	669	1	The	the	DT
cord-022594-fx044gcd	669	2	EBM	EBM	NNP
cord-022594-fx044gcd	669	3	calculations	calculation	NNS
cord-022594-fx044gcd	669	4	regarding	regard	VBG
cord-022594-fx044gcd	669	5	this	this	DT
cord-022594-fx044gcd	669	6	trial	trial	NN
cord-022594-fx044gcd	669	7	show	show	VBP
cord-022594-fx044gcd	669	8	an	an	DT
cord-022594-fx044gcd	669	9	RRR	RRR	NNP
cord-022594-fx044gcd	669	10	of	of	IN
cord-022594-fx044gcd	669	11	24	24	CD
cord-022594-fx044gcd	669	12	%	%	NN
cord-022594-fx044gcd	669	13	,	,	,
cord-022594-fx044gcd	669	14	and	and	CC
cord-022594-fx044gcd	669	15	ARR	arr	NN
cord-022594-fx044gcd	669	16	of	of	IN
cord-022594-fx044gcd	669	17	11	11	CD
cord-022594-fx044gcd	669	18	%	%	NN
cord-022594-fx044gcd	669	19	,	,	,
cord-022594-fx044gcd	669	20	and	and	CC
cord-022594-fx044gcd	669	21	an	an	DT
cord-022594-fx044gcd	669	22	NNT	nnt	NN
cord-022594-fx044gcd	669	23	of	of	IN
cord-022594-fx044gcd	669	24	9	9	CD
cord-022594-fx044gcd	669	25	patients	patient	NNS
cord-022594-fx044gcd	669	26	over	over	IN
cord-022594-fx044gcd	669	27	2	2	CD
cord-022594-fx044gcd	669	28	years	year	NNS
cord-022594-fx044gcd	669	29	in	in	IN
cord-022594-fx044gcd	669	30	order	order	NN
cord-022594-fx044gcd	669	31	to	to	TO
cord-022594-fx044gcd	669	32	prevent	prevent	VB
cord-022594-fx044gcd	669	33	one	one	CD
cord-022594-fx044gcd	669	34	conversion	conversion	NN
cord-022594-fx044gcd	669	35	to	to	IN
cord-022594-fx044gcd	669	36	"	"	``
cord-022594-fx044gcd	669	37	clinically	clinically	RB
cord-022594-fx044gcd	669	38	definite	definite	JJ
cord-022594-fx044gcd	669	39	MS	m	NNS
cord-022594-fx044gcd	669	40	.	.	.
cord-022594-fx044gcd	670	1	"	"	''
cord-022594-fx044gcd	671	1	These	these	DT
cord-022594-fx044gcd	671	2	two	two	CD
cord-022594-fx044gcd	671	3	studies	study	NNS
cord-022594-fx044gcd	671	4	provide	provide	VBP
cord-022594-fx044gcd	671	5	support	support	NN
cord-022594-fx044gcd	671	6	for	for	IN
cord-022594-fx044gcd	671	7	considering	consider	VBG
cord-022594-fx044gcd	671	8	early	early	JJ
cord-022594-fx044gcd	671	9	treatment	treatment	NN
cord-022594-fx044gcd	671	10	in	in	IN
cord-022594-fx044gcd	671	11	patients	patient	NNS
cord-022594-fx044gcd	671	12	presenting	present	VBG
cord-022594-fx044gcd	671	13	with	with	IN
cord-022594-fx044gcd	671	14	first	first	JJ
cord-022594-fx044gcd	671	15	attack	attack	NN
cord-022594-fx044gcd	671	16	,	,	,
cord-022594-fx044gcd	671	17	in	in	IN
cord-022594-fx044gcd	671	18	the	the	DT
cord-022594-fx044gcd	671	19	presence	presence	NN
cord-022594-fx044gcd	671	20	of	of	IN
cord-022594-fx044gcd	671	21	multiple	multiple	JJ
cord-022594-fx044gcd	671	22	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	671	23	MRI	MRI	NNP
cord-022594-fx044gcd	671	24	lesions	lesion	NNS
cord-022594-fx044gcd	671	25	,	,	,
cord-022594-fx044gcd	671	26	but	but	CC
cord-022594-fx044gcd	671	27	further	further	JJ
cord-022594-fx044gcd	671	28	studies	study	NNS
cord-022594-fx044gcd	671	29	are	be	VBP
cord-022594-fx044gcd	671	30	needed	need	VBN
cord-022594-fx044gcd	671	31	to	to	TO
cord-022594-fx044gcd	671	32	determine	determine	VB
cord-022594-fx044gcd	671	33	whether	whether	IN
cord-022594-fx044gcd	671	34	this	this	DT
cord-022594-fx044gcd	671	35	approach	approach	NN
cord-022594-fx044gcd	671	36	will	will	MD
cord-022594-fx044gcd	671	37	provide	provide	VB
cord-022594-fx044gcd	671	38	a	a	DT
cord-022594-fx044gcd	671	39	prolonged	prolonged	JJ
cord-022594-fx044gcd	671	40	benefit	benefit	NN
cord-022594-fx044gcd	671	41	on	on	IN
cord-022594-fx044gcd	671	42	disease	disease	NN
cord-022594-fx044gcd	671	43	course	course	NN
cord-022594-fx044gcd	671	44	.	.	.
cord-022594-fx044gcd	672	1	It	-PRON-	PRP
cord-022594-fx044gcd	672	2	is	be	VBZ
cord-022594-fx044gcd	672	3	important	important	JJ
cord-022594-fx044gcd	672	4	to	to	TO
cord-022594-fx044gcd	672	5	note	note	VB
cord-022594-fx044gcd	672	6	that	that	IN
cord-022594-fx044gcd	672	7	these	these	DT
cord-022594-fx044gcd	672	8	studies	study	NNS
cord-022594-fx044gcd	672	9	do	do	VBP
cord-022594-fx044gcd	672	10	not	not	RB
cord-022594-fx044gcd	672	11	provide	provide	VB
cord-022594-fx044gcd	672	12	guidance	guidance	NN
cord-022594-fx044gcd	672	13	about	about	IN
cord-022594-fx044gcd	672	14	clinically	clinically	RB
cord-022594-fx044gcd	672	15	isolated	isolate	VBN
cord-022594-fx044gcd	672	16	syndromes	syndrome	NNS
cord-022594-fx044gcd	672	17	that	that	WDT
cord-022594-fx044gcd	672	18	present	present	VBP
cord-022594-fx044gcd	672	19	with	with	IN
cord-022594-fx044gcd	672	20	a	a	DT
cord-022594-fx044gcd	672	21	brain	brain	NN
cord-022594-fx044gcd	672	22	MRI	mri	NN
cord-022594-fx044gcd	672	23	that	that	WDT
cord-022594-fx044gcd	672	24	is	be	VBZ
cord-022594-fx044gcd	672	25	not	not	RB
cord-022594-fx044gcd	672	26	suggestive	suggestive	JJ
cord-022594-fx044gcd	672	27	of	of	IN
cord-022594-fx044gcd	672	28	MS	MS	NNP
cord-022594-fx044gcd	672	29	(	(	-LRB-
cord-022594-fx044gcd	672	30	i.e.	i.e.	FW
cord-022594-fx044gcd	672	31	,	,	,
cord-022594-fx044gcd	672	32	only	only	RB
cord-022594-fx044gcd	672	33	one	one	CD
cord-022594-fx044gcd	672	34	optic	optic	JJ
cord-022594-fx044gcd	672	35	nerve	nerve	NN
cord-022594-fx044gcd	672	36	lesion	lesion	NN
cord-022594-fx044gcd	672	37	,	,	,
cord-022594-fx044gcd	672	38	or	or	CC
cord-022594-fx044gcd	672	39	one	one	CD
cord-022594-fx044gcd	672	40	brain	brain	NN
cord-022594-fx044gcd	672	41	stem	stem	NN
cord-022594-fx044gcd	672	42	or	or	CC
cord-022594-fx044gcd	672	43	cord	cord	NN
cord-022594-fx044gcd	672	44	lesion	lesion	NN
cord-022594-fx044gcd	672	45	explaining	explain	VBG
cord-022594-fx044gcd	672	46	the	the	DT
cord-022594-fx044gcd	672	47	CIS	CIS	NNP
cord-022594-fx044gcd	672	48	symptoms	symptom	NNS
cord-022594-fx044gcd	672	49	)	)	-RRB-
cord-022594-fx044gcd	672	50	.	.	.
cord-022594-fx044gcd	673	1	We	-PRON-	PRP
cord-022594-fx044gcd	673	2	do	do	VBP
cord-022594-fx044gcd	673	3	not	not	RB
cord-022594-fx044gcd	673	4	recommend	recommend	VB
cord-022594-fx044gcd	673	5	that	that	IN
cord-022594-fx044gcd	673	6	CIS	CIS	NNP
cord-022594-fx044gcd	673	7	patients	patient	NNS
cord-022594-fx044gcd	673	8	with	with	IN
cord-022594-fx044gcd	673	9	fewer	few	JJR
cord-022594-fx044gcd	673	10	than	than	IN
cord-022594-fx044gcd	673	11	two	two	CD
cord-022594-fx044gcd	673	12	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	673	13	MRI	MRI	NNP
cord-022594-fx044gcd	673	14	lesions	lesion	NNS
cord-022594-fx044gcd	673	15	receive	receive	VBP
cord-022594-fx044gcd	673	16	treatment	treatment	NN
cord-022594-fx044gcd	673	17	with	with	IN
cord-022594-fx044gcd	673	18	interferons	interferon	NNS
cord-022594-fx044gcd	673	19	.	.	.
cord-022594-fx044gcd	674	1	Please	please	UH
cord-022594-fx044gcd	674	2	see	see	VB
cord-022594-fx044gcd	674	3	the	the	DT
cord-022594-fx044gcd	674	4	discussions	discussion	NNS
cord-022594-fx044gcd	674	5	under	under	IN
cord-022594-fx044gcd	674	6	"	"	``
cord-022594-fx044gcd	674	7	Summary	Summary	NNP
cord-022594-fx044gcd	674	8	of	of	IN
cord-022594-fx044gcd	674	9	Recommendations	Recommendations	NNPS
cord-022594-fx044gcd	674	10	for	for	IN
cord-022594-fx044gcd	674	11	the	the	DT
cord-022594-fx044gcd	674	12	Treatment	Treatment	NNP
cord-022594-fx044gcd	674	13	of	of	IN
cord-022594-fx044gcd	674	14	RRMS	RRMS	NNP
cord-022594-fx044gcd	674	15	Patients	Patients	NNPS
cord-022594-fx044gcd	674	16	"	"	''
cord-022594-fx044gcd	674	17	for	for	IN
cord-022594-fx044gcd	674	18	further	further	JJ
cord-022594-fx044gcd	674	19	advice	advice	NN
cord-022594-fx044gcd	674	20	on	on	IN
cord-022594-fx044gcd	674	21	patient	patient	JJ
cord-022594-fx044gcd	674	22	counseling	counseling	NN
cord-022594-fx044gcd	674	23	and	and	CC
cord-022594-fx044gcd	674	24	decision	decision	NN
cord-022594-fx044gcd	674	25	making	make	VBG
cord-022594-fx044gcd	674	26	about	about	IN
cord-022594-fx044gcd	674	27	the	the	DT
cord-022594-fx044gcd	674	28	use	use	NN
cord-022594-fx044gcd	674	29	of	of	IN
cord-022594-fx044gcd	674	30	the	the	DT
cord-022594-fx044gcd	674	31	disease	disease	NN
cord-022594-fx044gcd	674	32	-	-	HYPH
cord-022594-fx044gcd	674	33	modifying	modify	VBG
cord-022594-fx044gcd	674	34	medications	medication	NNS
cord-022594-fx044gcd	674	35	.	.	.
cord-022594-fx044gcd	675	1	Altering	alter	VBG
cord-022594-fx044gcd	675	2	the	the	DT
cord-022594-fx044gcd	675	3	Course	course	NN
cord-022594-fx044gcd	675	4	of	of	IN
cord-022594-fx044gcd	675	5	Relapsing	relapse	VBG
cord-022594-fx044gcd	675	6	-	-	HYPH
cord-022594-fx044gcd	675	7	Remitting	remit	VBG
cord-022594-fx044gcd	675	8	Multiple	multiple	JJ
cord-022594-fx044gcd	675	9	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	675	10	b	b	NN
cord-022594-fx044gcd	675	11	-	-	:
cord-022594-fx044gcd	675	12	Interferons	Interferons	NNPS
cord-022594-fx044gcd	675	13	.	.	.
cord-022594-fx044gcd	676	1	Interferons	interferon	NNS
cord-022594-fx044gcd	676	2	are	be	VBP
cord-022594-fx044gcd	676	3	a	a	DT
cord-022594-fx044gcd	676	4	class	class	NN
cord-022594-fx044gcd	676	5	of	of	IN
cord-022594-fx044gcd	676	6	peptides	peptide	NNS
cord-022594-fx044gcd	676	7	that	that	WDT
cord-022594-fx044gcd	676	8	have	have	VBP
cord-022594-fx044gcd	676	9	antiviral	antiviral	JJ
cord-022594-fx044gcd	676	10	and	and	CC
cord-022594-fx044gcd	676	11	immunoregulatory	immunoregulatory	JJ
cord-022594-fx044gcd	676	12	functions	function	NNS
cord-022594-fx044gcd	676	13	.	.	.
cord-022594-fx044gcd	677	1	Both	both	DT
cord-022594-fx044gcd	677	2	interferon	interferon	NN
cord-022594-fx044gcd	677	3	-	-	:
cord-022594-fx044gcd	677	4	a	a	NN
cord-022594-fx044gcd	677	5	and	and	CC
cord-022594-fx044gcd	677	6	interferon	interferon	NN
cord-022594-fx044gcd	677	7	-	-	HYPH
cord-022594-fx044gcd	677	8	b	b	NN
cord-022594-fx044gcd	677	9	are	be	VBP
cord-022594-fx044gcd	677	10	part	part	NN
cord-022594-fx044gcd	677	11	of	of	IN
cord-022594-fx044gcd	677	12	the	the	DT
cord-022594-fx044gcd	677	13	anti	anti	JJ
cord-022594-fx044gcd	677	14	-	-	JJ
cord-022594-fx044gcd	677	15	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	677	16	T	t	NN
cord-022594-fx044gcd	677	17	H	h	NN
cord-022594-fx044gcd	677	18	2	2	CD
cord-022594-fx044gcd	677	19	response	response	NN
cord-022594-fx044gcd	677	20	.	.	.
cord-022594-fx044gcd	678	1	Interferon	interferon	NN
cord-022594-fx044gcd	678	2	-	-	HYPH
cord-022594-fx044gcd	678	3	b	b	NN
cord-022594-fx044gcd	678	4	1b	1b	CD
cord-022594-fx044gcd	678	5	(	(	-LRB-
cord-022594-fx044gcd	678	6	Betaseron	Betaseron	NNP
cord-022594-fx044gcd	678	7	)	)	-RRB-
cord-022594-fx044gcd	678	8	was	be	VBD
cord-022594-fx044gcd	678	9	the	the	DT
cord-022594-fx044gcd	678	10	first	first	JJ
cord-022594-fx044gcd	678	11	drug	drug	NN
cord-022594-fx044gcd	678	12	approved	approve	VBN
cord-022594-fx044gcd	678	13	by	by	IN
cord-022594-fx044gcd	678	14	the	the	DT
cord-022594-fx044gcd	678	15	U.S.	U.S.	NNP
cord-022594-fx044gcd	678	16	Food	Food	NNP
cord-022594-fx044gcd	678	17	and	and	CC
cord-022594-fx044gcd	678	18	Drug	Drug	NNP
cord-022594-fx044gcd	678	19	Administration	Administration	NNP
cord-022594-fx044gcd	678	20	(	(	-LRB-
cord-022594-fx044gcd	678	21	FDA	FDA	NNP
cord-022594-fx044gcd	678	22	)	)	-RRB-
cord-022594-fx044gcd	678	23	specifically	specifically	RB
cord-022594-fx044gcd	678	24	for	for	IN
cord-022594-fx044gcd	678	25	the	the	DT
cord-022594-fx044gcd	678	26	treatment	treatment	NN
cord-022594-fx044gcd	678	27	of	of	IN
cord-022594-fx044gcd	678	28	MS	MS	NNP
cord-022594-fx044gcd	678	29	.	.	.
cord-022594-fx044gcd	679	1	A	a	DT
cord-022594-fx044gcd	679	2	large	large	JJ
cord-022594-fx044gcd	679	3	clinical	clinical	JJ
cord-022594-fx044gcd	679	4	study	study	NN
cord-022594-fx044gcd	679	5	in	in	IN
cord-022594-fx044gcd	679	6	RRMS	RRMS	NNP
cord-022594-fx044gcd	679	7	patients	patient	NNS
cord-022594-fx044gcd	679	8	demonstrated	demonstrate	VBD
cord-022594-fx044gcd	679	9	a	a	DT
cord-022594-fx044gcd	679	10	reduction	reduction	NN
cord-022594-fx044gcd	679	11	in	in	IN
cord-022594-fx044gcd	679	12	the	the	DT
cord-022594-fx044gcd	679	13	frequency	frequency	NN
cord-022594-fx044gcd	679	14	of	of	IN
cord-022594-fx044gcd	679	15	relapses	relapse	NNS
cord-022594-fx044gcd	679	16	by	by	IN
cord-022594-fx044gcd	679	17	about	about	RB
cord-022594-fx044gcd	679	18	one	one	CD
cord-022594-fx044gcd	679	19	third	third	NN
cord-022594-fx044gcd	679	20	with	with	IN
cord-022594-fx044gcd	679	21	subcutaneous	subcutaneous	JJ
cord-022594-fx044gcd	679	22	injection	injection	NN
cord-022594-fx044gcd	679	23	every	every	DT
cord-022594-fx044gcd	679	24	other	other	JJ
cord-022594-fx044gcd	679	25	day	day	NN
cord-022594-fx044gcd	679	26	.	.	.
cord-022594-fx044gcd	680	1	64	64	CD
cord-022594-fx044gcd	681	1	The	the	DT
cord-022594-fx044gcd	681	2	severity	severity	NN
cord-022594-fx044gcd	681	3	of	of	IN
cord-022594-fx044gcd	681	4	relapses	relapse	NNS
cord-022594-fx044gcd	681	5	was	be	VBD
cord-022594-fx044gcd	681	6	also	also	RB
cord-022594-fx044gcd	681	7	lessened	lessen	VBN
cord-022594-fx044gcd	681	8	.	.	.
cord-022594-fx044gcd	682	1	Interferon	interferon	NN
cord-022594-fx044gcd	682	2	-	-	HYPH
cord-022594-fx044gcd	682	3	b	b	NN
cord-022594-fx044gcd	682	4	1b	1b	CD
cord-022594-fx044gcd	682	5	had	have	VBD
cord-022594-fx044gcd	682	6	a	a	DT
cord-022594-fx044gcd	682	7	striking	striking	JJ
cord-022594-fx044gcd	682	8	effect	effect	NN
cord-022594-fx044gcd	682	9	on	on	IN
cord-022594-fx044gcd	682	10	MRI	MRI	NNP
cord-022594-fx044gcd	682	11	measures	measure	NNS
cord-022594-fx044gcd	682	12	of	of	IN
cord-022594-fx044gcd	682	13	disease	disease	NN
cord-022594-fx044gcd	682	14	activity	activity	NN
cord-022594-fx044gcd	682	15	.	.	.
cord-022594-fx044gcd	683	1	The	the	DT
cord-022594-fx044gcd	683	2	placebo	placebo	NN
cord-022594-fx044gcd	683	3	-	-	HYPH
cord-022594-fx044gcd	683	4	control	control	NN
cord-022594-fx044gcd	683	5	group	group	NN
cord-022594-fx044gcd	683	6	continued	continue	VBD
cord-022594-fx044gcd	683	7	to	to	TO
cord-022594-fx044gcd	683	8	accumulate	accumulate	VB
cord-022594-fx044gcd	683	9	white	white	JJ
cord-022594-fx044gcd	683	10	matter	matter	NN
cord-022594-fx044gcd	683	11	lesions	lesion	NNS
cord-022594-fx044gcd	683	12	,	,	,
cord-022594-fx044gcd	683	13	whereas	whereas	IN
cord-022594-fx044gcd	683	14	patients	patient	NNS
cord-022594-fx044gcd	683	15	in	in	IN
cord-022594-fx044gcd	683	16	the	the	DT
cord-022594-fx044gcd	683	17	high	high	JJ
cord-022594-fx044gcd	683	18	-	-	HYPH
cord-022594-fx044gcd	683	19	dose	dose	NN
cord-022594-fx044gcd	683	20	arm	arm	NN
cord-022594-fx044gcd	683	21	(	(	-LRB-
cord-022594-fx044gcd	683	22	8	8	CD
cord-022594-fx044gcd	683	23	million	million	CD
cord-022594-fx044gcd	683	24	IU	IU	NNP
cord-022594-fx044gcd	683	25	)	)	-RRB-
cord-022594-fx044gcd	683	26	had	have	VBD
cord-022594-fx044gcd	683	27	stabilization	stabilization	NN
cord-022594-fx044gcd	683	28	of	of	IN
cord-022594-fx044gcd	683	29	their	-PRON-	PRP$
cord-022594-fx044gcd	683	30	MRI	MRI	NNP
cord-022594-fx044gcd	683	31	lesion	lesion	NN
cord-022594-fx044gcd	683	32	load	load	NN
cord-022594-fx044gcd	683	33	.	.	.
cord-022594-fx044gcd	684	1	No	no	DT
cord-022594-fx044gcd	684	2	difference	difference	NN
cord-022594-fx044gcd	684	3	was	be	VBD
cord-022594-fx044gcd	684	4	found	find	VBN
cord-022594-fx044gcd	684	5	in	in	IN
cord-022594-fx044gcd	684	6	the	the	DT
cord-022594-fx044gcd	684	7	disability	disability	NN
cord-022594-fx044gcd	684	8	levels	level	NNS
cord-022594-fx044gcd	684	9	,	,	,
cord-022594-fx044gcd	684	10	however	however	RB
cord-022594-fx044gcd	684	11	.	.	.
cord-022594-fx044gcd	685	1	Side	side	JJ
cord-022594-fx044gcd	685	2	effects	effect	NNS
cord-022594-fx044gcd	685	3	include	include	VBP
cord-022594-fx044gcd	685	4	injection	injection	NN
cord-022594-fx044gcd	685	5	site	site	NN
cord-022594-fx044gcd	685	6	reactions	reaction	NNS
cord-022594-fx044gcd	685	7	,	,	,
cord-022594-fx044gcd	685	8	flu	flu	NN
cord-022594-fx044gcd	685	9	-	-	HYPH
cord-022594-fx044gcd	685	10	like	like	JJ
cord-022594-fx044gcd	685	11	symptoms	symptom	NNS
cord-022594-fx044gcd	685	12	(	(	-LRB-
cord-022594-fx044gcd	685	13	low	low	JJ
cord-022594-fx044gcd	685	14	-	-	HYPH
cord-022594-fx044gcd	685	15	grade	grade	NN
cord-022594-fx044gcd	685	16	fever	fever	NN
cord-022594-fx044gcd	685	17	,	,	,
cord-022594-fx044gcd	685	18	myalgias	myalgias	NNP
cord-022594-fx044gcd	685	19	,	,	,
cord-022594-fx044gcd	685	20	headache	headache	NN
cord-022594-fx044gcd	685	21	;	;	:
cord-022594-fx044gcd	685	22	these	these	DT
cord-022594-fx044gcd	685	23	lessen	lessen	VBP
cord-022594-fx044gcd	685	24	in	in	IN
cord-022594-fx044gcd	685	25	frequency	frequency	NN
cord-022594-fx044gcd	685	26	after	after	IN
cord-022594-fx044gcd	685	27	treatment	treatment	NN
cord-022594-fx044gcd	685	28	for	for	IN
cord-022594-fx044gcd	685	29	a	a	DT
cord-022594-fx044gcd	685	30	few	few	JJ
cord-022594-fx044gcd	685	31	months	month	NNS
cord-022594-fx044gcd	685	32	)	)	-RRB-
cord-022594-fx044gcd	685	33	,	,	,
cord-022594-fx044gcd	685	34	mild	mild	JJ
cord-022594-fx044gcd	685	35	liver	liver	NN
cord-022594-fx044gcd	685	36	enzyme	enzyme	NN
cord-022594-fx044gcd	685	37	elevation	elevation	NN
cord-022594-fx044gcd	685	38	,	,	,
cord-022594-fx044gcd	685	39	and	and	CC
cord-022594-fx044gcd	685	40	lymphopenia	lymphopenia	NNP
cord-022594-fx044gcd	685	41	.	.	.
cord-022594-fx044gcd	686	1	Depression	depression	NN
cord-022594-fx044gcd	686	2	and	and	CC
cord-022594-fx044gcd	686	3	attempted	attempt	VBD
cord-022594-fx044gcd	686	4	suicide	suicide	NN
cord-022594-fx044gcd	686	5	were	be	VBD
cord-022594-fx044gcd	686	6	more	more	RBR
cord-022594-fx044gcd	686	7	common	common	JJ
cord-022594-fx044gcd	686	8	in	in	IN
cord-022594-fx044gcd	686	9	the	the	DT
cord-022594-fx044gcd	686	10	treated	treat	VBN
cord-022594-fx044gcd	686	11	groups	group	NNS
cord-022594-fx044gcd	686	12	.	.	.
cord-022594-fx044gcd	687	1	To	to	TO
cord-022594-fx044gcd	687	2	illustrate	illustrate	VB
cord-022594-fx044gcd	687	3	the	the	DT
cord-022594-fx044gcd	687	4	magnitude	magnitude	NN
cord-022594-fx044gcd	687	5	of	of	IN
cord-022594-fx044gcd	687	6	treatment	treatment	NN
cord-022594-fx044gcd	687	7	effect	effect	NN
cord-022594-fx044gcd	687	8	of	of	IN
cord-022594-fx044gcd	687	9	the	the	DT
cord-022594-fx044gcd	687	10	pivotal	pivotal	JJ
cord-022594-fx044gcd	687	11	interferon	interferon	NN
cord-022594-fx044gcd	687	12	-	-	HYPH
cord-022594-fx044gcd	687	13	b	b	NN
cord-022594-fx044gcd	687	14	1b	1b	CD
cord-022594-fx044gcd	687	15	trial	trial	NN
cord-022594-fx044gcd	687	16	,	,	,
cord-022594-fx044gcd	687	17	the	the	DT
cord-022594-fx044gcd	687	18	RRR	RRR	NNP
cord-022594-fx044gcd	687	19	was	be	VBD
cord-022594-fx044gcd	687	20	18	18	CD
cord-022594-fx044gcd	687	21	%	%	NN
cord-022594-fx044gcd	687	22	,	,	,
cord-022594-fx044gcd	687	23	the	the	DT
cord-022594-fx044gcd	687	24	ARR	arr	NN
cord-022594-fx044gcd	687	25	was	be	VBD
cord-022594-fx044gcd	687	26	15	15	CD
cord-022594-fx044gcd	687	27	%	%	NN
cord-022594-fx044gcd	687	28	,	,	,
cord-022594-fx044gcd	687	29	and	and	CC
cord-022594-fx044gcd	687	30	the	the	DT
cord-022594-fx044gcd	687	31	NNT	NNT	NNP
cord-022594-fx044gcd	687	32	analysis	analysis	NN
cord-022594-fx044gcd	687	33	showed	show	VBD
cord-022594-fx044gcd	687	34	that	that	IN
cord-022594-fx044gcd	687	35	7	7	CD
cord-022594-fx044gcd	687	36	patients	patient	NNS
cord-022594-fx044gcd	687	37	are	be	VBP
cord-022594-fx044gcd	687	38	needed	need	VBN
cord-022594-fx044gcd	687	39	to	to	TO
cord-022594-fx044gcd	687	40	be	be	VB
cord-022594-fx044gcd	687	41	treated	treat	VBN
cord-022594-fx044gcd	687	42	over	over	IN
cord-022594-fx044gcd	687	43	3	3	CD
cord-022594-fx044gcd	687	44	years	year	NNS
cord-022594-fx044gcd	687	45	to	to	TO
cord-022594-fx044gcd	687	46	increase	increase	VB
cord-022594-fx044gcd	687	47	the	the	DT
cord-022594-fx044gcd	687	48	number	number	NN
cord-022594-fx044gcd	687	49	of	of	IN
cord-022594-fx044gcd	687	50	those	those	DT
cord-022594-fx044gcd	687	51	who	who	WP
cord-022594-fx044gcd	687	52	were	be	VBD
cord-022594-fx044gcd	687	53	relapse	relapse	VBN
cord-022594-fx044gcd	687	54	free	free	JJ
cord-022594-fx044gcd	687	55	by	by	IN
cord-022594-fx044gcd	687	56	one	one	CD
cord-022594-fx044gcd	687	57	.	.	.
cord-022594-fx044gcd	688	1	One	one	CD
cord-022594-fx044gcd	688	2	particularly	particularly	RB
cord-022594-fx044gcd	688	3	disturbing	disturbing	JJ
cord-022594-fx044gcd	688	4	result	result	NN
cord-022594-fx044gcd	688	5	was	be	VBD
cord-022594-fx044gcd	688	6	the	the	DT
cord-022594-fx044gcd	688	7	production	production	NN
cord-022594-fx044gcd	688	8	of	of	IN
cord-022594-fx044gcd	688	9	neutralizing	neutralize	VBG
cord-022594-fx044gcd	688	10	autoantibodies	autoantibody	NNS
cord-022594-fx044gcd	688	11	(	(	-LRB-
cord-022594-fx044gcd	688	12	NAbs	NAbs	NNP
cord-022594-fx044gcd	688	13	)	)	-RRB-
cord-022594-fx044gcd	688	14	in	in	IN
cord-022594-fx044gcd	688	15	38	38	CD
cord-022594-fx044gcd	688	16	%	%	NN
cord-022594-fx044gcd	688	17	of	of	IN
cord-022594-fx044gcd	688	18	patients	patient	NNS
cord-022594-fx044gcd	688	19	after	after	IN
cord-022594-fx044gcd	688	20	3	3	CD
cord-022594-fx044gcd	688	21	years	year	NNS
cord-022594-fx044gcd	688	22	of	of	IN
cord-022594-fx044gcd	688	23	treatment	treatment	NN
cord-022594-fx044gcd	688	24	.	.	.
cord-022594-fx044gcd	689	1	Not	not	RB
cord-022594-fx044gcd	689	2	only	only	RB
cord-022594-fx044gcd	689	3	do	do	VBP
cord-022594-fx044gcd	689	4	patients	patient	NNS
cord-022594-fx044gcd	689	5	with	with	IN
cord-022594-fx044gcd	689	6	these	these	DT
cord-022594-fx044gcd	689	7	antibodies	antibody	NNS
cord-022594-fx044gcd	689	8	thereafter	thereafter	RB
cord-022594-fx044gcd	689	9	fail	fail	VBP
cord-022594-fx044gcd	689	10	to	to	TO
cord-022594-fx044gcd	689	11	respond	respond	VB
cord-022594-fx044gcd	689	12	to	to	IN
cord-022594-fx044gcd	689	13	this	this	DT
cord-022594-fx044gcd	689	14	drug	drug	NN
cord-022594-fx044gcd	689	15	,	,	,
cord-022594-fx044gcd	689	16	but	but	CC
cord-022594-fx044gcd	689	17	there	there	EX
cord-022594-fx044gcd	689	18	is	be	VBZ
cord-022594-fx044gcd	689	19	also	also	RB
cord-022594-fx044gcd	689	20	a	a	DT
cord-022594-fx044gcd	689	21	concern	concern	NN
cord-022594-fx044gcd	689	22	that	that	IN
cord-022594-fx044gcd	689	23	NAbs	NAbs	NNP
cord-022594-fx044gcd	689	24	may	may	MD
cord-022594-fx044gcd	689	25	cross	cross	VB
cord-022594-fx044gcd	689	26	-	-	VB
cord-022594-fx044gcd	689	27	react	react	VB
cord-022594-fx044gcd	689	28	with	with	IN
cord-022594-fx044gcd	689	29	natural	natural	JJ
cord-022594-fx044gcd	689	30	interferon	interferon	NN
cord-022594-fx044gcd	689	31	-	-	HYPH
cord-022594-fx044gcd	689	32	b	b	NN
cord-022594-fx044gcd	689	33	and	and	CC
cord-022594-fx044gcd	689	34	interfere	interfere	VB
cord-022594-fx044gcd	689	35	with	with	IN
cord-022594-fx044gcd	689	36	its	-PRON-	PRP$
cord-022594-fx044gcd	689	37	function	function	NN
cord-022594-fx044gcd	689	38	.	.	.
cord-022594-fx044gcd	690	1	All	all	DT
cord-022594-fx044gcd	690	2	positive	positive	JJ
cord-022594-fx044gcd	690	3	sera	sera	NN
cord-022594-fx044gcd	690	4	for	for	IN
cord-022594-fx044gcd	690	5	NAbs	NAbs	NNP
cord-022594-fx044gcd	690	6	seem	seem	VB
cord-022594-fx044gcd	690	7	to	to	TO
cord-022594-fx044gcd	690	8	cross	cross	VB
cord-022594-fx044gcd	690	9	-	-	VB
cord-022594-fx044gcd	690	10	react	react	VB
cord-022594-fx044gcd	690	11	with	with	IN
cord-022594-fx044gcd	690	12	both	both	CC
cord-022594-fx044gcd	690	13	interferon	interferon	NN
cord-022594-fx044gcd	690	14	-	-	HYPH
cord-022594-fx044gcd	690	15	b	b	NN
cord-022594-fx044gcd	690	16	1a	1a	CD
cord-022594-fx044gcd	690	17	and	and	CC
cord-022594-fx044gcd	690	18	1b	1b	CD
cord-022594-fx044gcd	690	19	.	.	.
cord-022594-fx044gcd	691	1	Switching	switch	VBG
cord-022594-fx044gcd	691	2	from	from	IN
cord-022594-fx044gcd	691	3	one	one	CD
cord-022594-fx044gcd	691	4	preparation	preparation	NN
cord-022594-fx044gcd	691	5	to	to	IN
cord-022594-fx044gcd	691	6	the	the	DT
cord-022594-fx044gcd	691	7	other	other	JJ
cord-022594-fx044gcd	691	8	does	do	VBZ
cord-022594-fx044gcd	691	9	not	not	RB
cord-022594-fx044gcd	691	10	change	change	VB
cord-022594-fx044gcd	691	11	the	the	DT
cord-022594-fx044gcd	691	12	pattern	pattern	NN
cord-022594-fx044gcd	691	13	of	of	IN
cord-022594-fx044gcd	691	14	antibody	antibody	NN
cord-022594-fx044gcd	691	15	response	response	NN
cord-022594-fx044gcd	691	16	.	.	.
cord-022594-fx044gcd	692	1	65	65	CD
cord-022594-fx044gcd	693	1	The	the	DT
cord-022594-fx044gcd	693	2	long	long	JJ
cord-022594-fx044gcd	693	3	-	-	HYPH
cord-022594-fx044gcd	693	4	term	term	NN
cord-022594-fx044gcd	693	5	effects	effect	NNS
cord-022594-fx044gcd	693	6	of	of	IN
cord-022594-fx044gcd	693	7	NAbs	NAbs	NNP
cord-022594-fx044gcd	693	8	are	be	VBP
cord-022594-fx044gcd	693	9	unknown	unknown	JJ
cord-022594-fx044gcd	693	10	.	.	.
cord-022594-fx044gcd	694	1	Recent	recent	JJ
cord-022594-fx044gcd	694	2	studies	study	NNS
cord-022594-fx044gcd	694	3	seem	seem	VBP
cord-022594-fx044gcd	694	4	to	to	TO
cord-022594-fx044gcd	694	5	support	support	VB
cord-022594-fx044gcd	694	6	that	that	DT
cord-022594-fx044gcd	694	7	NAb	NAb	NNP
cord-022594-fx044gcd	694	8	formation	formation	NN
cord-022594-fx044gcd	694	9	reduces	reduce	VBZ
cord-022594-fx044gcd	694	10	clinical	clinical	JJ
cord-022594-fx044gcd	694	11	and	and	CC
cord-022594-fx044gcd	694	12	MRI	MRI	NNP
cord-022594-fx044gcd	694	13	effects	effect	NNS
cord-022594-fx044gcd	694	14	although	although	IN
cord-022594-fx044gcd	694	15	often	often	RB
cord-022594-fx044gcd	694	16	NAb	nab	VBP
cord-022594-fx044gcd	694	17	formation	formation	NN
cord-022594-fx044gcd	694	18	subsides	subside	VBZ
cord-022594-fx044gcd	694	19	with	with	IN
cord-022594-fx044gcd	694	20	time	time	NN
cord-022594-fx044gcd	694	21	.	.	.
cord-022594-fx044gcd	695	1	There	there	EX
cord-022594-fx044gcd	695	2	are	be	VBP
cord-022594-fx044gcd	695	3	no	no	DT
cord-022594-fx044gcd	695	4	firm	firm	JJ
cord-022594-fx044gcd	695	5	guidelines	guideline	NNS
cord-022594-fx044gcd	695	6	for	for	IN
cord-022594-fx044gcd	695	7	monitoring	monitor	VBG
cord-022594-fx044gcd	695	8	NAb	NAb	NNP
cord-022594-fx044gcd	695	9	formation	formation	NN
cord-022594-fx044gcd	695	10	.	.	.
cord-022594-fx044gcd	696	1	Most	Most	JJS
cord-022594-fx044gcd	696	2	physicians	physician	NNS
cord-022594-fx044gcd	696	3	do	do	VBP
cord-022594-fx044gcd	696	4	not	not	RB
cord-022594-fx044gcd	696	5	measure	measure	VB
cord-022594-fx044gcd	696	6	NAbs	NAbs	NNP
cord-022594-fx044gcd	696	7	but	but	CC
cord-022594-fx044gcd	696	8	rather	rather	RB
cord-022594-fx044gcd	696	9	change	change	VB
cord-022594-fx044gcd	696	10	therapies	therapy	NNS
cord-022594-fx044gcd	696	11	empirically	empirically	RB
cord-022594-fx044gcd	696	12	when	when	WRB
cord-022594-fx044gcd	696	13	patients	patient	NNS
cord-022594-fx044gcd	696	14	appear	appear	VBP
cord-022594-fx044gcd	696	15	to	to	TO
cord-022594-fx044gcd	696	16	be	be	VB
cord-022594-fx044gcd	696	17	failing	fail	VBG
cord-022594-fx044gcd	696	18	treatment	treatment	NN
cord-022594-fx044gcd	696	19	.	.	.
cord-022594-fx044gcd	697	1	Low	low	JJ
cord-022594-fx044gcd	697	2	titer	titer	NN
cord-022594-fx044gcd	697	3	Nabs	Nabs	NNP
cord-022594-fx044gcd	697	4	may	may	MD
cord-022594-fx044gcd	697	5	be	be	VB
cord-022594-fx044gcd	697	6	just	just	RB
cord-022594-fx044gcd	697	7	transient	transient	JJ
cord-022594-fx044gcd	697	8	phenomenon	phenomenon	NN
cord-022594-fx044gcd	697	9	related	relate	VBN
cord-022594-fx044gcd	697	10	to	to	IN
cord-022594-fx044gcd	697	11	IFN	IFN	NNP
cord-022594-fx044gcd	697	12	treatment	treatment	NN
cord-022594-fx044gcd	697	13	;	;	.
cord-022594-fx044gcd	698	1	persistent	persistent	JJ
cord-022594-fx044gcd	698	2	high	high	JJ
cord-022594-fx044gcd	698	3	titer	titer	NN
cord-022594-fx044gcd	698	4	NAbs	NAbs	NNP
cord-022594-fx044gcd	698	5	on	on	IN
cord-022594-fx044gcd	698	6	two	two	CD
cord-022594-fx044gcd	698	7	consecutive	consecutive	JJ
cord-022594-fx044gcd	698	8	tests	test	NNS
cord-022594-fx044gcd	698	9	at	at	IN
cord-022594-fx044gcd	698	10	least	least	JJS
cord-022594-fx044gcd	698	11	6	6	CD
cord-022594-fx044gcd	698	12	months	month	NNS
cord-022594-fx044gcd	698	13	apart	apart	RB
cord-022594-fx044gcd	698	14	is	be	VBZ
cord-022594-fx044gcd	698	15	likely	likely	RB
cord-022594-fx044gcd	698	16	associated	associate	VBN
cord-022594-fx044gcd	698	17	with	with	IN
cord-022594-fx044gcd	698	18	poor	poor	JJ
cord-022594-fx044gcd	698	19	treatment	treatment	NN
cord-022594-fx044gcd	698	20	response	response	NN
cord-022594-fx044gcd	698	21	to	to	IN
cord-022594-fx044gcd	698	22	INF	INF	NNP
cord-022594-fx044gcd	698	23	.	.	.
cord-022594-fx044gcd	699	1	Interferon	interferon	NN
cord-022594-fx044gcd	699	2	-	-	HYPH
cord-022594-fx044gcd	699	3	b	b	NN
cord-022594-fx044gcd	699	4	1a	1a	CD
cord-022594-fx044gcd	699	5	(	(	-LRB-
cord-022594-fx044gcd	699	6	Avonex	Avonex	NNP
cord-022594-fx044gcd	699	7	)	)	-RRB-
cord-022594-fx044gcd	699	8	has	have	VBZ
cord-022594-fx044gcd	699	9	the	the	DT
cord-022594-fx044gcd	699	10	same	same	JJ
cord-022594-fx044gcd	699	11	amino	amino	NN
cord-022594-fx044gcd	699	12	acid	acid	NN
cord-022594-fx044gcd	699	13	sequence	sequence	NN
cord-022594-fx044gcd	699	14	as	as	IN
cord-022594-fx044gcd	699	15	natural	natural	JJ
cord-022594-fx044gcd	699	16	interferon	interferon	NN
cord-022594-fx044gcd	699	17	-	-	HYPH
cord-022594-fx044gcd	699	18	b	b	NN
cord-022594-fx044gcd	699	19	and	and	CC
cord-022594-fx044gcd	699	20	differs	differ	VBZ
cord-022594-fx044gcd	699	21	from	from	IN
cord-022594-fx044gcd	699	22	interferon	interferon	NN
cord-022594-fx044gcd	699	23	-	-	HYPH
cord-022594-fx044gcd	699	24	b	b	NN
cord-022594-fx044gcd	699	25	1b	1b	CD
cord-022594-fx044gcd	699	26	by	by	IN
cord-022594-fx044gcd	699	27	one	one	CD
cord-022594-fx044gcd	699	28	amino	amino	NN
cord-022594-fx044gcd	699	29	acid	acid	NN
cord-022594-fx044gcd	699	30	as	as	RB
cord-022594-fx044gcd	699	31	well	well	RB
cord-022594-fx044gcd	699	32	as	as	IN
cord-022594-fx044gcd	699	33	by	by	IN
cord-022594-fx044gcd	699	34	the	the	DT
cord-022594-fx044gcd	699	35	presence	presence	NN
cord-022594-fx044gcd	699	36	of	of	IN
cord-022594-fx044gcd	699	37	carbohydrate	carbohydrate	NN
cord-022594-fx044gcd	699	38	moieties	moiety	NNS
cord-022594-fx044gcd	699	39	.	.	.
cord-022594-fx044gcd	700	1	Once	once	RB
cord-022594-fx044gcd	700	2	-	-	HYPH
cord-022594-fx044gcd	700	3	weekly	weekly	JJ
cord-022594-fx044gcd	700	4	intramuscular	intramuscular	JJ
cord-022594-fx044gcd	700	5	interferon	interferon	NN
cord-022594-fx044gcd	700	6	-	-	HYPH
cord-022594-fx044gcd	700	7	b	b	NN
cord-022594-fx044gcd	700	8	1a	1a	NN
cord-022594-fx044gcd	700	9	has	have	VBZ
cord-022594-fx044gcd	700	10	been	be	VBN
cord-022594-fx044gcd	700	11	found	find	VBN
cord-022594-fx044gcd	700	12	to	to	TO
cord-022594-fx044gcd	700	13	have	have	VB
cord-022594-fx044gcd	700	14	effects	effect	NNS
cord-022594-fx044gcd	700	15	similar	similar	JJ
cord-022594-fx044gcd	700	16	to	to	IN
cord-022594-fx044gcd	700	17	that	that	DT
cord-022594-fx044gcd	700	18	of	of	IN
cord-022594-fx044gcd	700	19	interferon	interferon	NN
cord-022594-fx044gcd	700	20	-	-	HYPH
cord-022594-fx044gcd	700	21	b	b	NN
cord-022594-fx044gcd	700	22	1b	1b	CD
cord-022594-fx044gcd	700	23	in	in	IN
cord-022594-fx044gcd	700	24	reducing	reduce	VBG
cord-022594-fx044gcd	700	25	the	the	DT
cord-022594-fx044gcd	700	26	frequency	frequency	NN
cord-022594-fx044gcd	700	27	of	of	IN
cord-022594-fx044gcd	700	28	MS	MS	NNP
cord-022594-fx044gcd	700	29	relapses	relapse	NNS
cord-022594-fx044gcd	700	30	.	.	.
cord-022594-fx044gcd	701	1	In	in	IN
cord-022594-fx044gcd	701	2	addition	addition	NN
cord-022594-fx044gcd	701	3	,	,	,
cord-022594-fx044gcd	701	4	a	a	DT
cord-022594-fx044gcd	701	5	favorable	favorable	JJ
cord-022594-fx044gcd	701	6	effect	effect	NN
cord-022594-fx044gcd	701	7	on	on	IN
cord-022594-fx044gcd	701	8	disability	disability	NN
cord-022594-fx044gcd	701	9	was	be	VBD
cord-022594-fx044gcd	701	10	also	also	RB
cord-022594-fx044gcd	701	11	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	701	12	and	and	CC
cord-022594-fx044gcd	701	13	side	side	NN
cord-022594-fx044gcd	701	14	effects	effect	NNS
cord-022594-fx044gcd	701	15	were	be	VBD
cord-022594-fx044gcd	701	16	less	less	RBR
cord-022594-fx044gcd	701	17	common	common	JJ
cord-022594-fx044gcd	701	18	.	.	.
cord-022594-fx044gcd	702	1	In	in	IN
cord-022594-fx044gcd	702	2	the	the	DT
cord-022594-fx044gcd	702	3	original	original	JJ
cord-022594-fx044gcd	702	4	interferon	interferon	NN
cord-022594-fx044gcd	702	5	-	-	HYPH
cord-022594-fx044gcd	702	6	b	b	NN
cord-022594-fx044gcd	702	7	1-a	1-a	CD
cord-022594-fx044gcd	702	8	intramuscular	intramuscular	JJ
cord-022594-fx044gcd	702	9	trial	trial	NN
cord-022594-fx044gcd	702	10	,	,	,
cord-022594-fx044gcd	702	11	the	the	DT
cord-022594-fx044gcd	702	12	primary	primary	JJ
cord-022594-fx044gcd	702	13	outcome	outcome	NN
cord-022594-fx044gcd	702	14	measure	measure	NN
cord-022594-fx044gcd	702	15	was	be	VBD
cord-022594-fx044gcd	702	16	time	time	NN
cord-022594-fx044gcd	702	17	to	to	IN
cord-022594-fx044gcd	702	18	EDSS	EDSS	NNP
cord-022594-fx044gcd	702	19	progression	progression	NN
cord-022594-fx044gcd	702	20	.	.	.
cord-022594-fx044gcd	703	1	The	the	DT
cord-022594-fx044gcd	703	2	RRR	RRR	NNP
cord-022594-fx044gcd	703	3	was	be	VBD
cord-022594-fx044gcd	703	4	37	37	CD
cord-022594-fx044gcd	703	5	%	%	NN
cord-022594-fx044gcd	703	6	,	,	,
cord-022594-fx044gcd	703	7	the	the	DT
cord-022594-fx044gcd	703	8	ARR	arr	NN
cord-022594-fx044gcd	703	9	was	be	VBD
cord-022594-fx044gcd	703	10	13	13	CD
cord-022594-fx044gcd	703	11	%	%	NN
cord-022594-fx044gcd	703	12	,	,	,
cord-022594-fx044gcd	703	13	and	and	CC
cord-022594-fx044gcd	703	14	the	the	DT
cord-022594-fx044gcd	703	15	NNT	NNT	NNP
cord-022594-fx044gcd	703	16	was	be	VBD
cord-022594-fx044gcd	703	17	8	8	CD
cord-022594-fx044gcd	703	18	for	for	IN
cord-022594-fx044gcd	703	19	2	2	CD
cord-022594-fx044gcd	703	20	years	year	NNS
cord-022594-fx044gcd	703	21	to	to	TO
cord-022594-fx044gcd	703	22	prevent	prevent	VB
cord-022594-fx044gcd	703	23	one	one	CD
cord-022594-fx044gcd	703	24	patient	patient	NN
cord-022594-fx044gcd	703	25	from	from	IN
cord-022594-fx044gcd	703	26	developing	develop	VBG
cord-022594-fx044gcd	703	27	EDSS	EDSS	NNP
cord-022594-fx044gcd	703	28	progression	progression	NN
cord-022594-fx044gcd	703	29	.	.	.
cord-022594-fx044gcd	704	1	The	the	DT
cord-022594-fx044gcd	704	2	calculations	calculation	NNS
cord-022594-fx044gcd	704	3	for	for	IN
cord-022594-fx044gcd	704	4	"	"	``
cord-022594-fx044gcd	704	5	proportion	proportion	NN
cord-022594-fx044gcd	704	6	relapse	relapse	VB
cord-022594-fx044gcd	704	7	free	free	JJ
cord-022594-fx044gcd	704	8	"	"	''
cord-022594-fx044gcd	704	9	show	show	VBP
cord-022594-fx044gcd	704	10	an	an	DT
cord-022594-fx044gcd	704	11	RRR	RRR	NNP
cord-022594-fx044gcd	704	12	of	of	IN
cord-022594-fx044gcd	704	13	16	16	CD
cord-022594-fx044gcd	704	14	%	%	NN
cord-022594-fx044gcd	704	15	,	,	,
cord-022594-fx044gcd	704	16	and	and	CC
cord-022594-fx044gcd	704	17	ARR	arr	NN
cord-022594-fx044gcd	704	18	of	of	IN
cord-022594-fx044gcd	704	19	12	12	CD
cord-022594-fx044gcd	704	20	%	%	NN
cord-022594-fx044gcd	704	21	,	,	,
cord-022594-fx044gcd	704	22	and	and	CC
cord-022594-fx044gcd	704	23	an	an	DT
cord-022594-fx044gcd	704	24	NNT	nnt	NN
cord-022594-fx044gcd	704	25	of	of	IN
cord-022594-fx044gcd	704	26	8	8	CD
cord-022594-fx044gcd	704	27	over	over	IN
cord-022594-fx044gcd	704	28	2	2	CD
cord-022594-fx044gcd	704	29	years	year	NNS
cord-022594-fx044gcd	704	30	(	(	-LRB-
cord-022594-fx044gcd	704	31	8	8	CD
cord-022594-fx044gcd	704	32	patients	patient	NNS
cord-022594-fx044gcd	704	33	need	need	VBP
cord-022594-fx044gcd	704	34	to	to	TO
cord-022594-fx044gcd	704	35	be	be	VB
cord-022594-fx044gcd	704	36	treated	treat	VBN
cord-022594-fx044gcd	704	37	for	for	IN
cord-022594-fx044gcd	704	38	2	2	CD
cord-022594-fx044gcd	704	39	years	year	NNS
cord-022594-fx044gcd	704	40	to	to	TO
cord-022594-fx044gcd	704	41	increase	increase	VB
cord-022594-fx044gcd	704	42	the	the	DT
cord-022594-fx044gcd	704	43	number	number	NN
cord-022594-fx044gcd	704	44	of	of	IN
cord-022594-fx044gcd	704	45	patients	patient	NNS
cord-022594-fx044gcd	704	46	who	who	WP
cord-022594-fx044gcd	704	47	were	be	VBD
cord-022594-fx044gcd	704	48	relapse	relapse	VBN
cord-022594-fx044gcd	704	49	free	free	JJ
cord-022594-fx044gcd	704	50	by	by	IN
cord-022594-fx044gcd	704	51	one	one	CD
cord-022594-fx044gcd	704	52	)	)	-RRB-
cord-022594-fx044gcd	704	53	.	.	.
cord-022594-fx044gcd	705	1	NAbs	NAbs	NNP
cord-022594-fx044gcd	705	2	occurred	occur	VBD
cord-022594-fx044gcd	705	3	half	half	NN
cord-022594-fx044gcd	705	4	as	as	RB
cord-022594-fx044gcd	705	5	often	often	RB
cord-022594-fx044gcd	705	6	as	as	IN
cord-022594-fx044gcd	705	7	with	with	IN
cord-022594-fx044gcd	705	8	interferon	interferon	NN
cord-022594-fx044gcd	705	9	-	-	HYPH
cord-022594-fx044gcd	705	10	b	b	NN
cord-022594-fx044gcd	705	11	1b	1b	CD
cord-022594-fx044gcd	705	12	.	.	.
cord-022594-fx044gcd	706	1	Interferon	interferon	NN
cord-022594-fx044gcd	706	2	-	-	HYPH
cord-022594-fx044gcd	706	3	b	b	NN
cord-022594-fx044gcd	706	4	1a	1a	NN
cord-022594-fx044gcd	706	5	has	have	VBZ
cord-022594-fx044gcd	706	6	been	be	VBN
cord-022594-fx044gcd	706	7	approved	approve	VBN
cord-022594-fx044gcd	706	8	by	by	IN
cord-022594-fx044gcd	706	9	the	the	DT
cord-022594-fx044gcd	706	10	FDA	FDA	NNP
cord-022594-fx044gcd	706	11	for	for	IN
cord-022594-fx044gcd	706	12	treatment	treatment	NN
cord-022594-fx044gcd	706	13	of	of	IN
cord-022594-fx044gcd	706	14	"	"	``
cord-022594-fx044gcd	706	15	relapsing	relapse	VBG
cord-022594-fx044gcd	706	16	MS	MS	NNP
cord-022594-fx044gcd	706	17	.	.	.
cord-022594-fx044gcd	706	18	"	"	''
cord-022594-fx044gcd	707	1	66	66	CD
cord-022594-fx044gcd	708	1	The	the	DT
cord-022594-fx044gcd	708	2	"	"	``
cord-022594-fx044gcd	708	3	correct	correct	JJ
cord-022594-fx044gcd	708	4	"	"	''
cord-022594-fx044gcd	708	5	dose	dose	NN
cord-022594-fx044gcd	708	6	of	of	IN
cord-022594-fx044gcd	708	7	interferon	interferon	NN
cord-022594-fx044gcd	708	8	continues	continue	VBZ
cord-022594-fx044gcd	708	9	to	to	TO
cord-022594-fx044gcd	708	10	be	be	VB
cord-022594-fx044gcd	708	11	debated	debate	VBN
cord-022594-fx044gcd	708	12	.	.	.
cord-022594-fx044gcd	709	1	In	in	IN
cord-022594-fx044gcd	709	2	a	a	DT
cord-022594-fx044gcd	709	3	recent	recent	JJ
cord-022594-fx044gcd	709	4	placebo	placebo	NN
cord-022594-fx044gcd	709	5	-	-	HYPH
cord-022594-fx044gcd	709	6	controlled	control	VBN
cord-022594-fx044gcd	709	7	trial	trial	NN
cord-022594-fx044gcd	709	8	,	,	,
cord-022594-fx044gcd	709	9	patients	patient	NNS
cord-022594-fx044gcd	709	10	randomized	randomize	VBN
cord-022594-fx044gcd	709	11	to	to	IN
cord-022594-fx044gcd	709	12	a	a	DT
cord-022594-fx044gcd	709	13	high	high	JJ
cord-022594-fx044gcd	709	14	dose	dose	NN
cord-022594-fx044gcd	709	15	of	of	IN
cord-022594-fx044gcd	709	16	interferon	interferon	NN
cord-022594-fx044gcd	709	17	-	-	HYPH
cord-022594-fx044gcd	709	18	b	b	NN
cord-022594-fx044gcd	709	19	1a	1a	CD
cord-022594-fx044gcd	709	20	(	(	-LRB-
cord-022594-fx044gcd	709	21	44	44	CD
cord-022594-fx044gcd	709	22	mg	mg	NNP
cord-022594-fx044gcd	709	23	three	three	CD
cord-022594-fx044gcd	709	24	times	time	NNS
cord-022594-fx044gcd	709	25	per	per	IN
cord-022594-fx044gcd	709	26	week	week	NN
cord-022594-fx044gcd	709	27	)	)	-RRB-
cord-022594-fx044gcd	709	28	did	do	VBD
cord-022594-fx044gcd	709	29	better	well	RBR
cord-022594-fx044gcd	709	30	than	than	IN
cord-022594-fx044gcd	709	31	those	those	DT
cord-022594-fx044gcd	709	32	receiving	receive	VBG
cord-022594-fx044gcd	709	33	half	half	PDT
cord-022594-fx044gcd	709	34	this	this	DT
cord-022594-fx044gcd	709	35	weekly	weekly	JJ
cord-022594-fx044gcd	709	36	dose	dose	NN
cord-022594-fx044gcd	709	37	.	.	.
cord-022594-fx044gcd	710	1	Both	both	DT
cord-022594-fx044gcd	710	2	groups	group	NNS
cord-022594-fx044gcd	710	3	outperformed	outperform	VBD
cord-022594-fx044gcd	710	4	placebo	placebo	NN
cord-022594-fx044gcd	710	5	and	and	CC
cord-022594-fx044gcd	710	6	the	the	DT
cord-022594-fx044gcd	710	7	high	high	JJ
cord-022594-fx044gcd	710	8	dose	dose	NN
cord-022594-fx044gcd	710	9	seemed	seem	VBD
cord-022594-fx044gcd	710	10	to	to	TO
cord-022594-fx044gcd	710	11	have	have	VB
cord-022594-fx044gcd	710	12	more	more	JJR
cord-022594-fx044gcd	710	13	effect	effect	NN
cord-022594-fx044gcd	710	14	on	on	IN
cord-022594-fx044gcd	710	15	relapse	relapse	NN
cord-022594-fx044gcd	710	16	severity	severity	NN
cord-022594-fx044gcd	710	17	,	,	,
cord-022594-fx044gcd	710	18	hospitalizations	hospitalization	NNS
cord-022594-fx044gcd	710	19	,	,	,
cord-022594-fx044gcd	710	20	MRI	MRI	NNP
cord-022594-fx044gcd	710	21	activity	activity	NN
cord-022594-fx044gcd	710	22	,	,	,
cord-022594-fx044gcd	710	23	and	and	CC
cord-022594-fx044gcd	710	24	lesion	lesion	NN
cord-022594-fx044gcd	710	25	volume	volume	NN
cord-022594-fx044gcd	710	26	accumulation	accumulation	NN
cord-022594-fx044gcd	710	27	,	,	,
cord-022594-fx044gcd	710	28	and	and	CC
cord-022594-fx044gcd	710	29	possibly	possibly	RB
cord-022594-fx044gcd	710	30	on	on	IN
cord-022594-fx044gcd	710	31	delaying	delay	VBG
cord-022594-fx044gcd	710	32	disability	disability	NN
cord-022594-fx044gcd	710	33	in	in	IN
cord-022594-fx044gcd	710	34	the	the	DT
cord-022594-fx044gcd	710	35	most	most	RBS
cord-022594-fx044gcd	710	36	severely	severely	RB
cord-022594-fx044gcd	710	37	disabled	disabled	JJ
cord-022594-fx044gcd	710	38	patients	patient	NNS
cord-022594-fx044gcd	710	39	.	.	.
cord-022594-fx044gcd	711	1	At	at	IN
cord-022594-fx044gcd	711	2	the	the	DT
cord-022594-fx044gcd	711	3	end	end	NN
cord-022594-fx044gcd	711	4	of	of	IN
cord-022594-fx044gcd	711	5	the	the	DT
cord-022594-fx044gcd	711	6	2	2	CD
cord-022594-fx044gcd	711	7	years	year	NNS
cord-022594-fx044gcd	711	8	of	of	IN
cord-022594-fx044gcd	711	9	follow	follow	NN
cord-022594-fx044gcd	711	10	-	-	HYPH
cord-022594-fx044gcd	711	11	up	up	NN
cord-022594-fx044gcd	711	12	,	,	,
cord-022594-fx044gcd	711	13	placebo	placebo	NN
cord-022594-fx044gcd	711	14	-	-	HYPH
cord-022594-fx044gcd	711	15	treated	treat	VBN
cord-022594-fx044gcd	711	16	patients	patient	NNS
cord-022594-fx044gcd	711	17	were	be	VBD
cord-022594-fx044gcd	711	18	randomized	randomize	VBN
cord-022594-fx044gcd	711	19	to	to	IN
cord-022594-fx044gcd	711	20	22	22	CD
cord-022594-fx044gcd	711	21	or	or	CC
cord-022594-fx044gcd	711	22	44	44	CD
cord-022594-fx044gcd	711	23	mg	mg	NNS
cord-022594-fx044gcd	711	24	subcutaneously	subcutaneously	RB
cord-022594-fx044gcd	711	25	three	three	CD
cord-022594-fx044gcd	711	26	times	time	NNS
cord-022594-fx044gcd	711	27	weekly	weekly	JJ
cord-022594-fx044gcd	711	28	;	;	:
cord-022594-fx044gcd	711	29	patients	patient	NNS
cord-022594-fx044gcd	711	30	on	on	IN
cord-022594-fx044gcd	711	31	active	active	JJ
cord-022594-fx044gcd	711	32	treatment	treatment	NN
cord-022594-fx044gcd	711	33	were	be	VBD
cord-022594-fx044gcd	711	34	continued	continue	VBN
cord-022594-fx044gcd	711	35	on	on	IN
cord-022594-fx044gcd	711	36	their	-PRON-	PRP$
cord-022594-fx044gcd	711	37	original	original	JJ
cord-022594-fx044gcd	711	38	dose	dose	NN
cord-022594-fx044gcd	711	39	.	.	.
cord-022594-fx044gcd	712	1	67	67	CD
cord-022594-fx044gcd	713	1	The	the	DT
cord-022594-fx044gcd	713	2	authors	author	NNS
cord-022594-fx044gcd	713	3	reported	report	VBD
cord-022594-fx044gcd	713	4	a	a	DT
cord-022594-fx044gcd	713	5	benefit	benefit	NN
cord-022594-fx044gcd	713	6	for	for	IN
cord-022594-fx044gcd	713	7	the	the	DT
cord-022594-fx044gcd	713	8	higher	high	JJR
cord-022594-fx044gcd	713	9	dose	dose	NN
cord-022594-fx044gcd	713	10	and	and	CC
cord-022594-fx044gcd	713	11	for	for	IN
cord-022594-fx044gcd	713	12	those	those	DT
cord-022594-fx044gcd	713	13	treated	treat	VBN
cord-022594-fx044gcd	713	14	for	for	IN
cord-022594-fx044gcd	713	15	the	the	DT
cord-022594-fx044gcd	713	16	full	full	JJ
cord-022594-fx044gcd	713	17	4	4	CD
cord-022594-fx044gcd	713	18	years	year	NNS
cord-022594-fx044gcd	713	19	,	,	,
cord-022594-fx044gcd	713	20	again	again	RB
cord-022594-fx044gcd	713	21	suggesting	suggest	VBG
cord-022594-fx044gcd	713	22	that	that	IN
cord-022594-fx044gcd	713	23	early	early	JJ
cord-022594-fx044gcd	713	24	treatment	treatment	NN
cord-022594-fx044gcd	713	25	and	and	CC
cord-022594-fx044gcd	713	26	perhaps	perhaps	RB
cord-022594-fx044gcd	713	27	higher	high	JJR
cord-022594-fx044gcd	713	28	doses	dose	NNS
cord-022594-fx044gcd	713	29	of	of	IN
cord-022594-fx044gcd	713	30	interferons	interferon	NNS
cord-022594-fx044gcd	713	31	may	may	MD
cord-022594-fx044gcd	713	32	be	be	VB
cord-022594-fx044gcd	713	33	beneficial	beneficial	JJ
cord-022594-fx044gcd	713	34	.	.	.
cord-022594-fx044gcd	714	1	The	the	DT
cord-022594-fx044gcd	714	2	primary	primary	JJ
cord-022594-fx044gcd	714	3	outcome	outcome	NN
cord-022594-fx044gcd	714	4	,	,	,
cord-022594-fx044gcd	714	5	however	however	RB
cord-022594-fx044gcd	714	6	,	,	,
cord-022594-fx044gcd	714	7	was	be	VBD
cord-022594-fx044gcd	714	8	relapse	relapse	NN
cord-022594-fx044gcd	714	9	count	count	NN
cord-022594-fx044gcd	714	10	per	per	IN
cord-022594-fx044gcd	714	11	patient	patient	NN
cord-022594-fx044gcd	714	12	per	per	IN
cord-022594-fx044gcd	714	13	4	4	CD
cord-022594-fx044gcd	714	14	years	year	NNS
cord-022594-fx044gcd	714	15	and	and	CC
cord-022594-fx044gcd	714	16	,	,	,
cord-022594-fx044gcd	714	17	as	as	IN
cord-022594-fx044gcd	714	18	such	such	JJ
cord-022594-fx044gcd	714	19	,	,	,
cord-022594-fx044gcd	714	20	patients	patient	NNS
cord-022594-fx044gcd	714	21	treated	treat	VBN
cord-022594-fx044gcd	714	22	early	early	RB
cord-022594-fx044gcd	714	23	had	have	VBD
cord-022594-fx044gcd	714	24	a	a	DT
cord-022594-fx044gcd	714	25	significant	significant	JJ
cord-022594-fx044gcd	714	26	advantage	advantage	NN
cord-022594-fx044gcd	714	27	using	use	VBG
cord-022594-fx044gcd	714	28	this	this	DT
cord-022594-fx044gcd	714	29	outcome	outcome	NN
cord-022594-fx044gcd	714	30	measure	measure	NN
cord-022594-fx044gcd	714	31	.	.	.
cord-022594-fx044gcd	715	1	There	there	EX
cord-022594-fx044gcd	715	2	were	be	VBD
cord-022594-fx044gcd	715	3	trends	trend	NNS
cord-022594-fx044gcd	715	4	favoring	favor	VBG
cord-022594-fx044gcd	715	5	the	the	DT
cord-022594-fx044gcd	715	6	higher	high	JJR
cord-022594-fx044gcd	715	7	dose	dose	NN
cord-022594-fx044gcd	715	8	(	(	-LRB-
cord-022594-fx044gcd	715	9	relapse	relapse	NN
cord-022594-fx044gcd	715	10	rate	rate	NN
cord-022594-fx044gcd	715	11	,	,	,
cord-022594-fx044gcd	715	12	MRI	MRI	NNP
cord-022594-fx044gcd	715	13	volumes	volume	NNS
cord-022594-fx044gcd	715	14	;	;	:
cord-022594-fx044gcd	715	15	not	not	RB
cord-022594-fx044gcd	715	16	for	for	IN
cord-022594-fx044gcd	715	17	time	time	NN
cord-022594-fx044gcd	715	18	to	to	IN
cord-022594-fx044gcd	715	19	first	first	RB
cord-022594-fx044gcd	715	20	confirmed	confirm	VBN
cord-022594-fx044gcd	715	21	progression	progression	NN
cord-022594-fx044gcd	715	22	,	,	,
cord-022594-fx044gcd	715	23	however	however	RB
cord-022594-fx044gcd	715	24	)	)	-RRB-
cord-022594-fx044gcd	715	25	.	.	.
cord-022594-fx044gcd	716	1	The	the	DT
cord-022594-fx044gcd	716	2	authors	author	NNS
cord-022594-fx044gcd	716	3	did	do	VBD
cord-022594-fx044gcd	716	4	not	not	RB
cord-022594-fx044gcd	716	5	make	make	VB
cord-022594-fx044gcd	716	6	statistical	statistical	JJ
cord-022594-fx044gcd	716	7	adjustments	adjustment	NNS
cord-022594-fx044gcd	716	8	for	for	IN
cord-022594-fx044gcd	716	9	multiple	multiple	JJ
cord-022594-fx044gcd	716	10	comparisons	comparison	NNS
cord-022594-fx044gcd	716	11	and	and	CC
cord-022594-fx044gcd	716	12	there	there	EX
cord-022594-fx044gcd	716	13	were	be	VBD
cord-022594-fx044gcd	716	14	many	many	JJ
cord-022594-fx044gcd	716	15	dropouts	dropout	NNS
cord-022594-fx044gcd	716	16	in	in	IN
cord-022594-fx044gcd	716	17	the	the	DT
cord-022594-fx044gcd	716	18	high	high	JJ
cord-022594-fx044gcd	716	19	-	-	HYPH
cord-022594-fx044gcd	716	20	dose	dose	NN
cord-022594-fx044gcd	716	21	groups	group	NNS
cord-022594-fx044gcd	716	22	,	,	,
cord-022594-fx044gcd	716	23	making	make	VBG
cord-022594-fx044gcd	716	24	it	-PRON-	PRP
cord-022594-fx044gcd	716	25	difficult	difficult	JJ
cord-022594-fx044gcd	716	26	to	to	TO
cord-022594-fx044gcd	716	27	draw	draw	VB
cord-022594-fx044gcd	716	28	firm	firm	JJ
cord-022594-fx044gcd	716	29	conclusions	conclusion	NNS
cord-022594-fx044gcd	716	30	.	.	.
cord-022594-fx044gcd	717	1	Again	again	RB
cord-022594-fx044gcd	717	2	,	,	,
cord-022594-fx044gcd	717	3	the	the	DT
cord-022594-fx044gcd	717	4	answer	answer	NN
cord-022594-fx044gcd	717	5	to	to	IN
cord-022594-fx044gcd	717	6	the	the	DT
cord-022594-fx044gcd	717	7	question	question	NN
cord-022594-fx044gcd	717	8	about	about	IN
cord-022594-fx044gcd	717	9	the	the	DT
cord-022594-fx044gcd	717	10	benefit	benefit	NN
cord-022594-fx044gcd	717	11	of	of	IN
cord-022594-fx044gcd	717	12	early	early	JJ
cord-022594-fx044gcd	717	13	treatment	treatment	NN
cord-022594-fx044gcd	717	14	can	can	MD
cord-022594-fx044gcd	717	15	best	best	RB
cord-022594-fx044gcd	717	16	come	come	VB
cord-022594-fx044gcd	717	17	from	from	IN
cord-022594-fx044gcd	717	18	long	long	JJ
cord-022594-fx044gcd	717	19	-	-	HYPH
cord-022594-fx044gcd	717	20	term	term	NN
cord-022594-fx044gcd	717	21	(	(	-LRB-
cord-022594-fx044gcd	717	22	perhaps	perhaps	RB
cord-022594-fx044gcd	717	23	8	8	CD
cord-022594-fx044gcd	717	24	to	to	TO
cord-022594-fx044gcd	717	25	10	10	CD
cord-022594-fx044gcd	717	26	years	year	NNS
cord-022594-fx044gcd	717	27	)	)	-RRB-
cord-022594-fx044gcd	717	28	studies	study	NNS
cord-022594-fx044gcd	717	29	using	use	VBG
cord-022594-fx044gcd	717	30	"	"	``
cord-022594-fx044gcd	717	31	hard	hard	JJ
cord-022594-fx044gcd	717	32	outcomes	outcome	NNS
cord-022594-fx044gcd	717	33	"	"	''
cord-022594-fx044gcd	717	34	(	(	-LRB-
cord-022594-fx044gcd	717	35	e.g.	e.g.	RB
cord-022594-fx044gcd	717	36	,	,	,
cord-022594-fx044gcd	717	37	time	time	NN
cord-022594-fx044gcd	717	38	to	to	IN
cord-022594-fx044gcd	717	39	progression	progression	NN
cord-022594-fx044gcd	717	40	,	,	,
cord-022594-fx044gcd	717	41	major	major	JJ
cord-022594-fx044gcd	717	42	milestones	milestone	NNS
cord-022594-fx044gcd	717	43	in	in	IN
cord-022594-fx044gcd	717	44	disability	disability	NN
cord-022594-fx044gcd	717	45	)	)	-RRB-
cord-022594-fx044gcd	717	46	.	.	.
cord-022594-fx044gcd	718	1	The	the	DT
cord-022594-fx044gcd	718	2	EBM	EBM	NNP
cord-022594-fx044gcd	718	3	calculations	calculation	NNS
cord-022594-fx044gcd	718	4	based	base	VBN
cord-022594-fx044gcd	718	5	on	on	IN
cord-022594-fx044gcd	718	6	the	the	DT
cord-022594-fx044gcd	718	7	"	"	``
cord-022594-fx044gcd	718	8	proportion	proportion	NN
cord-022594-fx044gcd	718	9	relapse	relapse	NN
cord-022594-fx044gcd	719	1	free	free	JJ
cord-022594-fx044gcd	719	2	"	"	''
cord-022594-fx044gcd	719	3	data	datum	NNS
cord-022594-fx044gcd	719	4	for	for	IN
cord-022594-fx044gcd	719	5	the	the	DT
cord-022594-fx044gcd	719	6	original	original	JJ
cord-022594-fx044gcd	719	7	interferon	interferon	NN
cord-022594-fx044gcd	719	8	-	-	HYPH
cord-022594-fx044gcd	719	9	b	b	NN
cord-022594-fx044gcd	719	10	1a	1a	CD
cord-022594-fx044gcd	720	1	(	(	-LRB-
cord-022594-fx044gcd	720	2	Rebif	Rebif	NNP
cord-022594-fx044gcd	720	3	)	)	-RRB-
cord-022594-fx044gcd	720	4	study	study	NN
cord-022594-fx044gcd	720	5	show	show	VBP
cord-022594-fx044gcd	720	6	an	an	DT
cord-022594-fx044gcd	720	7	RRR	RRR	NNP
cord-022594-fx044gcd	720	8	of	of	IN
cord-022594-fx044gcd	720	9	19	19	CD
cord-022594-fx044gcd	720	10	%	%	NN
cord-022594-fx044gcd	720	11	,	,	,
cord-022594-fx044gcd	720	12	and	and	CC
cord-022594-fx044gcd	720	13	ARR	arr	NN
cord-022594-fx044gcd	720	14	of	of	IN
cord-022594-fx044gcd	720	15	16	16	CD
cord-022594-fx044gcd	720	16	%	%	NN
cord-022594-fx044gcd	720	17	,	,	,
cord-022594-fx044gcd	720	18	and	and	CC
cord-022594-fx044gcd	720	19	an	an	DT
cord-022594-fx044gcd	720	20	NNT	nnt	NN
cord-022594-fx044gcd	720	21	of	of	IN
cord-022594-fx044gcd	720	22	6	6	CD
cord-022594-fx044gcd	720	23	over	over	IN
cord-022594-fx044gcd	720	24	2	2	CD
cord-022594-fx044gcd	720	25	years	year	NNS
cord-022594-fx044gcd	720	26	to	to	TO
cord-022594-fx044gcd	720	27	increase	increase	VB
cord-022594-fx044gcd	720	28	the	the	DT
cord-022594-fx044gcd	720	29	number	number	NN
cord-022594-fx044gcd	720	30	of	of	IN
cord-022594-fx044gcd	720	31	relapse	relapse	NN
cord-022594-fx044gcd	720	32	free	free	JJ
cord-022594-fx044gcd	720	33	by	by	IN
cord-022594-fx044gcd	720	34	one	one	CD
cord-022594-fx044gcd	720	35	.	.	.
cord-022594-fx044gcd	721	1	Relative	relative	JJ
cord-022594-fx044gcd	721	2	treatment	treatment	NN
cord-022594-fx044gcd	721	3	advantages	advantage	NNS
cord-022594-fx044gcd	721	4	of	of	IN
cord-022594-fx044gcd	721	5	interferon	interferon	NN
cord-022594-fx044gcd	721	6	-	-	HYPH
cord-022594-fx044gcd	721	7	b	b	NN
cord-022594-fx044gcd	721	8	1a	1a	CD
cord-022594-fx044gcd	721	9	and	and	CC
cord-022594-fx044gcd	721	10	1b	1b	CD
cord-022594-fx044gcd	721	11	have	have	VBP
cord-022594-fx044gcd	721	12	not	not	RB
cord-022594-fx044gcd	721	13	been	be	VBN
cord-022594-fx044gcd	721	14	clearly	clearly	RB
cord-022594-fx044gcd	721	15	established	establish	VBN
cord-022594-fx044gcd	721	16	but	but	CC
cord-022594-fx044gcd	721	17	are	be	VBP
cord-022594-fx044gcd	721	18	under	under	IN
cord-022594-fx044gcd	721	19	study	study	NN
cord-022594-fx044gcd	721	20	.	.	.
cord-022594-fx044gcd	722	1	68	68	CD
cord-022594-fx044gcd	723	1	,	,	,
cord-022594-fx044gcd	723	2	69	69	CD
cord-022594-fx044gcd	724	1	A	a	DT
cord-022594-fx044gcd	724	2	pilot	pilot	NN
cord-022594-fx044gcd	724	3	study	study	NN
cord-022594-fx044gcd	724	4	in	in	IN
cord-022594-fx044gcd	724	5	RRMS	RRMS	NNP
cord-022594-fx044gcd	724	6	patients	patient	NNS
cord-022594-fx044gcd	724	7	suggests	suggest	VBZ
cord-022594-fx044gcd	724	8	that	that	IN
cord-022594-fx044gcd	724	9	interferon	interferon	NN
cord-022594-fx044gcd	724	10	-	-	:
cord-022594-fx044gcd	724	11	a	a	DT
cord-022594-fx044gcd	724	12	may	may	MD
cord-022594-fx044gcd	724	13	also	also	RB
cord-022594-fx044gcd	724	14	have	have	VB
cord-022594-fx044gcd	724	15	a	a	DT
cord-022594-fx044gcd	724	16	therapeutic	therapeutic	JJ
cord-022594-fx044gcd	724	17	effect	effect	NN
cord-022594-fx044gcd	724	18	.	.	.
cord-022594-fx044gcd	725	1	70	70	CD
cord-022594-fx044gcd	726	1	A	a	DT
cord-022594-fx044gcd	726	2	study	study	NN
cord-022594-fx044gcd	726	3	of	of	IN
cord-022594-fx044gcd	726	4	interferon	interferon	NN
cord-022594-fx044gcd	726	5	responders	responder	NNS
cord-022594-fx044gcd	726	6	showed	show	VBD
cord-022594-fx044gcd	726	7	that	that	IN
cord-022594-fx044gcd	726	8	younger	young	JJR
cord-022594-fx044gcd	726	9	patients	patient	NNS
cord-022594-fx044gcd	726	10	with	with	IN
cord-022594-fx044gcd	726	11	frequent	frequent	JJ
cord-022594-fx044gcd	726	12	relapses	relapse	NNS
cord-022594-fx044gcd	726	13	,	,	,
cord-022594-fx044gcd	726	14	and	and	CC
cord-022594-fx044gcd	726	15	higher	high	JJR
cord-022594-fx044gcd	726	16	EDSS	EDSS	NNP
cord-022594-fx044gcd	726	17	scores	score	NNS
cord-022594-fx044gcd	726	18	upon	upon	IN
cord-022594-fx044gcd	726	19	entry	entry	NN
cord-022594-fx044gcd	726	20	may	may	MD
cord-022594-fx044gcd	726	21	be	be	VB
cord-022594-fx044gcd	726	22	associated	associate	VBN
cord-022594-fx044gcd	726	23	better	well	JJR
cord-022594-fx044gcd	726	24	response	response	NN
cord-022594-fx044gcd	726	25	.	.	.
cord-022594-fx044gcd	727	1	71	71	CD
cord-022594-fx044gcd	727	2	Laboratory	Laboratory	NNP
cord-022594-fx044gcd	727	3	Monitoring	Monitoring	NNP
cord-022594-fx044gcd	727	4	of	of	IN
cord-022594-fx044gcd	727	5	Interferon	Interferon	NNP
cord-022594-fx044gcd	727	6	Products	Products	NNP
cord-022594-fx044gcd	727	7	.	.	.
cord-022594-fx044gcd	728	1	It	-PRON-	PRP
cord-022594-fx044gcd	728	2	is	be	VBZ
cord-022594-fx044gcd	728	3	important	important	JJ
cord-022594-fx044gcd	728	4	to	to	TO
cord-022594-fx044gcd	728	5	note	note	VB
cord-022594-fx044gcd	728	6	that	that	IN
cord-022594-fx044gcd	728	7	even	even	RB
cord-022594-fx044gcd	728	8	though	though	IN
cord-022594-fx044gcd	728	9	the	the	DT
cord-022594-fx044gcd	728	10	interferon	interferon	NN
cord-022594-fx044gcd	728	11	products	product	NNS
cord-022594-fx044gcd	728	12	are	be	VBP
cord-022594-fx044gcd	728	13	generally	generally	RB
cord-022594-fx044gcd	728	14	safe	safe	JJ
cord-022594-fx044gcd	728	15	to	to	TO
cord-022594-fx044gcd	728	16	use	use	VB
cord-022594-fx044gcd	728	17	,	,	,
cord-022594-fx044gcd	728	18	they	-PRON-	PRP
cord-022594-fx044gcd	728	19	can	can	MD
cord-022594-fx044gcd	728	20	be	be	VB
cord-022594-fx044gcd	728	21	associated	associate	VBN
cord-022594-fx044gcd	728	22	with	with	IN
cord-022594-fx044gcd	728	23	potentially	potentially	RB
cord-022594-fx044gcd	728	24	harmful	harmful	JJ
cord-022594-fx044gcd	728	25	adverse	adverse	JJ
cord-022594-fx044gcd	728	26	reactions	reaction	NNS
cord-022594-fx044gcd	728	27	.	.	.
cord-022594-fx044gcd	729	1	We	-PRON-	PRP
cord-022594-fx044gcd	729	2	recommend	recommend	VBP
cord-022594-fx044gcd	729	3	that	that	IN
cord-022594-fx044gcd	729	4	every	every	DT
cord-022594-fx044gcd	729	5	newly	newly	RB
cord-022594-fx044gcd	729	6	starting	start	VBG
cord-022594-fx044gcd	729	7	patient	patient	NN
cord-022594-fx044gcd	729	8	should	should	MD
cord-022594-fx044gcd	729	9	have	have	VB
cord-022594-fx044gcd	729	10	a	a	DT
cord-022594-fx044gcd	729	11	baseline	baseline	JJ
cord-022594-fx044gcd	729	12	complete	complete	JJ
cord-022594-fx044gcd	729	13	blood	blood	NN
cord-022594-fx044gcd	729	14	count	count	NN
cord-022594-fx044gcd	729	15	,	,	,
cord-022594-fx044gcd	729	16	liver	liver	NN
cord-022594-fx044gcd	729	17	function	function	NN
cord-022594-fx044gcd	729	18	tests	test	NNS
cord-022594-fx044gcd	729	19	,	,	,
cord-022594-fx044gcd	729	20	and	and	CC
cord-022594-fx044gcd	729	21	thyroid	thyroid	NN
cord-022594-fx044gcd	729	22	-	-	HYPH
cord-022594-fx044gcd	729	23	stimulating	stimulate	VBG
cord-022594-fx044gcd	729	24	hormone	hormone	NN
cord-022594-fx044gcd	729	25	(	(	-LRB-
cord-022594-fx044gcd	729	26	TSH	TSH	NNP
cord-022594-fx044gcd	729	27	)	)	-RRB-
cord-022594-fx044gcd	729	28	test	test	NN
cord-022594-fx044gcd	729	29	.	.	.
cord-022594-fx044gcd	730	1	The	the	DT
cord-022594-fx044gcd	730	2	liver	liver	NN
cord-022594-fx044gcd	730	3	function	function	NN
cord-022594-fx044gcd	730	4	tests	test	NNS
cord-022594-fx044gcd	730	5	and	and	CC
cord-022594-fx044gcd	730	6	blood	blood	NN
cord-022594-fx044gcd	730	7	count	count	NN
cord-022594-fx044gcd	730	8	studies	study	NNS
cord-022594-fx044gcd	730	9	should	should	MD
cord-022594-fx044gcd	730	10	be	be	VB
cord-022594-fx044gcd	730	11	repeated	repeat	VBN
cord-022594-fx044gcd	730	12	in	in	IN
cord-022594-fx044gcd	730	13	1	1	CD
cord-022594-fx044gcd	730	14	week	week	NN
cord-022594-fx044gcd	730	15	,	,	,
cord-022594-fx044gcd	730	16	1	1	CD
cord-022594-fx044gcd	730	17	month	month	NN
cord-022594-fx044gcd	730	18	,	,	,
cord-022594-fx044gcd	730	19	and	and	CC
cord-022594-fx044gcd	730	20	every	every	DT
cord-022594-fx044gcd	730	21	3	3	CD
cord-022594-fx044gcd	730	22	months	month	NNS
cord-022594-fx044gcd	730	23	thereafter	thereafter	RB
cord-022594-fx044gcd	730	24	;	;	:
cord-022594-fx044gcd	730	25	the	the	DT
cord-022594-fx044gcd	730	26	TSH	TSH	NNP
cord-022594-fx044gcd	730	27	should	should	MD
cord-022594-fx044gcd	730	28	be	be	VB
cord-022594-fx044gcd	730	29	repeated	repeat	VBN
cord-022594-fx044gcd	730	30	every	every	DT
cord-022594-fx044gcd	730	31	6	6	CD
cord-022594-fx044gcd	730	32	to	to	TO
cord-022594-fx044gcd	730	33	12	12	CD
cord-022594-fx044gcd	730	34	months	month	NNS
cord-022594-fx044gcd	730	35	.	.	.
cord-022594-fx044gcd	731	1	Glatiramer	Glatiramer	NNP
cord-022594-fx044gcd	731	2	Acetate	Acetate	NNP
cord-022594-fx044gcd	731	3	.	.	.
cord-022594-fx044gcd	732	1	Glatiramer	glatiramer	JJ
cord-022594-fx044gcd	732	2	acetate	acetate	NN
cord-022594-fx044gcd	732	3	(	(	-LRB-
cord-022594-fx044gcd	732	4	GA	GA	NNP
cord-022594-fx044gcd	732	5	)	)	-RRB-
cord-022594-fx044gcd	732	6	is	be	VBZ
cord-022594-fx044gcd	732	7	a	a	DT
cord-022594-fx044gcd	732	8	synthetic	synthetic	JJ
cord-022594-fx044gcd	732	9	mixture	mixture	NN
cord-022594-fx044gcd	732	10	of	of	IN
cord-022594-fx044gcd	732	11	polypeptides	polypeptide	NNS
cord-022594-fx044gcd	732	12	produced	produce	VBN
cord-022594-fx044gcd	732	13	by	by	IN
cord-022594-fx044gcd	732	14	the	the	DT
cord-022594-fx044gcd	732	15	random	random	JJ
cord-022594-fx044gcd	732	16	combinations	combination	NNS
cord-022594-fx044gcd	732	17	of	of	IN
cord-022594-fx044gcd	732	18	four	four	CD
cord-022594-fx044gcd	732	19	amino	amino	NN
cord-022594-fx044gcd	732	20	acids	acid	NNS
cord-022594-fx044gcd	732	21	that	that	WDT
cord-022594-fx044gcd	732	22	are	be	VBP
cord-022594-fx044gcd	732	23	frequent	frequent	JJ
cord-022594-fx044gcd	732	24	in	in	IN
cord-022594-fx044gcd	732	25	MBP	MBP	NNP
cord-022594-fx044gcd	732	26	.	.	.
cord-022594-fx044gcd	733	1	After	after	IN
cord-022594-fx044gcd	733	2	a	a	DT
cord-022594-fx044gcd	733	3	preliminary	preliminary	JJ
cord-022594-fx044gcd	733	4	study	study	NN
cord-022594-fx044gcd	733	5	suggested	suggest	VBD
cord-022594-fx044gcd	733	6	efficacy	efficacy	NN
cord-022594-fx044gcd	733	7	,	,	,
cord-022594-fx044gcd	733	8	72	72	CD
cord-022594-fx044gcd	733	9	a	a	DT
cord-022594-fx044gcd	733	10	phase	phase	NN
cord-022594-fx044gcd	733	11	III	iii	CD
cord-022594-fx044gcd	734	1	randomized	randomized	JJ
cord-022594-fx044gcd	734	2	,	,	,
cord-022594-fx044gcd	734	3	double	double	JJ
cord-022594-fx044gcd	734	4	-	-	HYPH
cord-022594-fx044gcd	734	5	blind	blind	JJ
cord-022594-fx044gcd	734	6	,	,	,
cord-022594-fx044gcd	734	7	placebo	placebo	NN
cord-022594-fx044gcd	734	8	-	-	HYPH
cord-022594-fx044gcd	734	9	controlled	control	VBN
cord-022594-fx044gcd	734	10	,	,	,
cord-022594-fx044gcd	734	11	multicenter	multicenter	JJ
cord-022594-fx044gcd	734	12	trial	trial	NN
cord-022594-fx044gcd	734	13	showed	show	VBD
cord-022594-fx044gcd	734	14	a	a	DT
cord-022594-fx044gcd	734	15	29	29	CD
cord-022594-fx044gcd	734	16	%	%	NN
cord-022594-fx044gcd	734	17	reduction	reduction	NN
cord-022594-fx044gcd	734	18	in	in	IN
cord-022594-fx044gcd	734	19	relapse	relapse	NN
cord-022594-fx044gcd	734	20	rate	rate	NN
cord-022594-fx044gcd	734	21	.	.	.
cord-022594-fx044gcd	735	1	73	73	CD
cord-022594-fx044gcd	736	1	The	the	DT
cord-022594-fx044gcd	736	2	FDA	FDA	NNP
cord-022594-fx044gcd	736	3	has	have	VBZ
cord-022594-fx044gcd	736	4	approved	approve	VBN
cord-022594-fx044gcd	736	5	this	this	DT
cord-022594-fx044gcd	736	6	medication	medication	NN
cord-022594-fx044gcd	736	7	for	for	IN
cord-022594-fx044gcd	736	8	use	use	NN
cord-022594-fx044gcd	736	9	in	in	IN
cord-022594-fx044gcd	736	10	RRMS	RRMS	NNP
cord-022594-fx044gcd	736	11	.	.	.
cord-022594-fx044gcd	737	1	Even	even	RB
cord-022594-fx044gcd	737	2	though	though	IN
cord-022594-fx044gcd	737	3	this	this	DT
cord-022594-fx044gcd	737	4	disease	disease	NN
cord-022594-fx044gcd	737	5	-	-	HYPH
cord-022594-fx044gcd	737	6	modifying	modify	VBG
cord-022594-fx044gcd	737	7	therapy	therapy	NN
cord-022594-fx044gcd	737	8	requires	require	VBZ
cord-022594-fx044gcd	737	9	daily	daily	JJ
cord-022594-fx044gcd	737	10	subcutaneous	subcutaneous	JJ
cord-022594-fx044gcd	737	11	administration	administration	NN
cord-022594-fx044gcd	737	12	,	,	,
cord-022594-fx044gcd	737	13	the	the	DT
cord-022594-fx044gcd	737	14	side	side	NN
cord-022594-fx044gcd	737	15	effects	effect	NNS
cord-022594-fx044gcd	737	16	are	be	VBP
cord-022594-fx044gcd	737	17	relatively	relatively	RB
cord-022594-fx044gcd	737	18	minor	minor	JJ
cord-022594-fx044gcd	737	19	compared	compare	VBN
cord-022594-fx044gcd	737	20	to	to	IN
cord-022594-fx044gcd	737	21	the	the	DT
cord-022594-fx044gcd	737	22	interferons	interferon	NNS
cord-022594-fx044gcd	737	23	,	,	,
cord-022594-fx044gcd	737	24	and	and	CC
cord-022594-fx044gcd	737	25	patients	patient	NNS
cord-022594-fx044gcd	737	26	do	do	VBP
cord-022594-fx044gcd	737	27	not	not	RB
cord-022594-fx044gcd	737	28	need	need	VB
cord-022594-fx044gcd	737	29	regular	regular	JJ
cord-022594-fx044gcd	737	30	laboratory	laboratory	NN
cord-022594-fx044gcd	737	31	monitoring	monitoring	NN
cord-022594-fx044gcd	737	32	(	(	-LRB-
cord-022594-fx044gcd	737	33	Table	table	NN
cord-022594-fx044gcd	737	34	48-	48-	CD
cord-022594-fx044gcd	737	35	lesions	lesion	NNS
cord-022594-fx044gcd	737	36	,	,	,
cord-022594-fx044gcd	737	37	lesion	lesion	NN
cord-022594-fx044gcd	737	38	volumes	volume	NNS
cord-022594-fx044gcd	737	39	,	,	,
cord-022594-fx044gcd	737	40	and	and	CC
cord-022594-fx044gcd	737	41	the	the	DT
cord-022594-fx044gcd	737	42	percentage	percentage	NN
cord-022594-fx044gcd	737	43	of	of	IN
cord-022594-fx044gcd	737	44	new	new	JJ
cord-022594-fx044gcd	737	45	lesions	lesion	NNS
cord-022594-fx044gcd	737	46	that	that	WDT
cord-022594-fx044gcd	737	47	will	will	MD
cord-022594-fx044gcd	737	48	evolve	evolve	VB
cord-022594-fx044gcd	737	49	into	into	IN
cord-022594-fx044gcd	737	50	T1	T1	NNP
cord-022594-fx044gcd	737	51	"	"	``
cord-022594-fx044gcd	737	52	black	black	JJ
cord-022594-fx044gcd	737	53	holes	hole	NNS
cord-022594-fx044gcd	737	54	,	,	,
cord-022594-fx044gcd	737	55	"	"	''
cord-022594-fx044gcd	737	56	although	although	IN
cord-022594-fx044gcd	737	57	the	the	DT
cord-022594-fx044gcd	737	58	MRI	MRI	NNP
cord-022594-fx044gcd	737	59	effect	effect	NN
cord-022594-fx044gcd	737	60	may	may	MD
cord-022594-fx044gcd	737	61	be	be	VB
cord-022594-fx044gcd	737	62	less	less	RBR
cord-022594-fx044gcd	737	63	pronounced	pronounced	JJ
cord-022594-fx044gcd	737	64	compared	compare	VBN
cord-022594-fx044gcd	737	65	to	to	IN
cord-022594-fx044gcd	737	66	the	the	DT
cord-022594-fx044gcd	737	67	interferon	interferon	NN
cord-022594-fx044gcd	737	68	products	product	NNS
cord-022594-fx044gcd	737	69	,	,	,
cord-022594-fx044gcd	737	70	and	and	CC
cord-022594-fx044gcd	737	71	is	be	VBZ
cord-022594-fx044gcd	737	72	not	not	RB
cord-022594-fx044gcd	737	73	apparent	apparent	JJ
cord-022594-fx044gcd	737	74	until	until	IN
cord-022594-fx044gcd	737	75	the	the	DT
cord-022594-fx044gcd	737	76	agent	agent	NN
cord-022594-fx044gcd	737	77	has	have	VBZ
cord-022594-fx044gcd	737	78	been	be	VBN
cord-022594-fx044gcd	737	79	used	use	VBN
cord-022594-fx044gcd	737	80	for	for	IN
cord-022594-fx044gcd	737	81	at	at	RB
cord-022594-fx044gcd	737	82	least	least	RBS
cord-022594-fx044gcd	737	83	6	6	CD
cord-022594-fx044gcd	737	84	months	month	NNS
cord-022594-fx044gcd	737	85	.	.	.
cord-022594-fx044gcd	738	1	[	[	-LRB-
cord-022594-fx044gcd	738	2	74	74	CD
cord-022594-fx044gcd	738	3	]	]	-RRB-
cord-022594-fx044gcd	738	4	[	[	-LRB-
cord-022594-fx044gcd	738	5	75	75	CD
cord-022594-fx044gcd	738	6	]	]	-RRB-
cord-022594-fx044gcd	739	1	[	[	-LRB-
cord-022594-fx044gcd	739	2	76	76	CD
cord-022594-fx044gcd	739	3	]	]	-RRB-
cord-022594-fx044gcd	740	1	The	the	DT
cord-022594-fx044gcd	740	2	EBM	EBM	NNP
cord-022594-fx044gcd	740	3	calculations	calculation	NNS
cord-022594-fx044gcd	740	4	for	for	IN
cord-022594-fx044gcd	740	5	GA	GA	NNP
cord-022594-fx044gcd	740	6	using	use	VBG
cord-022594-fx044gcd	740	7	the	the	DT
cord-022594-fx044gcd	740	8	"	"	``
cord-022594-fx044gcd	740	9	proportion	proportion	NN
cord-022594-fx044gcd	740	10	relapse	relapse	VB
cord-022594-fx044gcd	740	11	free	free	JJ
cord-022594-fx044gcd	741	1	"	"	``
cord-022594-fx044gcd	741	2	data	datum	NNS
cord-022594-fx044gcd	741	3	show	show	VBP
cord-022594-fx044gcd	741	4	an	an	DT
cord-022594-fx044gcd	741	5	RRR	RRR	NNP
cord-022594-fx044gcd	741	6	of	of	IN
cord-022594-fx044gcd	741	7	10	10	CD
cord-022594-fx044gcd	741	8	%	%	NN
cord-022594-fx044gcd	741	9	,	,	,
cord-022594-fx044gcd	741	10	ARR	arr	NN
cord-022594-fx044gcd	741	11	of	of	IN
cord-022594-fx044gcd	741	12	7	7	CD
cord-022594-fx044gcd	741	13	%	%	NN
cord-022594-fx044gcd	741	14	,	,	,
cord-022594-fx044gcd	741	15	and	and	CC
cord-022594-fx044gcd	741	16	an	an	DT
cord-022594-fx044gcd	741	17	NNT	nnt	NN
cord-022594-fx044gcd	741	18	of	of	IN
cord-022594-fx044gcd	741	19	14	14	CD
cord-022594-fx044gcd	741	20	over	over	IN
cord-022594-fx044gcd	741	21	2	2	CD
cord-022594-fx044gcd	741	22	years	year	NNS
cord-022594-fx044gcd	741	23	to	to	TO
cord-022594-fx044gcd	741	24	increase	increase	VB
cord-022594-fx044gcd	741	25	the	the	DT
cord-022594-fx044gcd	741	26	number	number	NN
cord-022594-fx044gcd	741	27	of	of	IN
cord-022594-fx044gcd	741	28	relapse	relapse	NN
cord-022594-fx044gcd	741	29	free	free	JJ
cord-022594-fx044gcd	741	30	by	by	IN
cord-022594-fx044gcd	741	31	one	one	CD
cord-022594-fx044gcd	741	32	.	.	.
cord-022594-fx044gcd	742	1	Combined	combine	VBN
cord-022594-fx044gcd	742	2	Azathioprine	Azathioprine	NNP
cord-022594-fx044gcd	742	3	and	and	CC
cord-022594-fx044gcd	742	4	Interferon	interferon	NN
cord-022594-fx044gcd	742	5	-	-	HYPH
cord-022594-fx044gcd	742	6	b	b	NN
cord-022594-fx044gcd	742	7	1b	1b	CD
cord-022594-fx044gcd	742	8	.	.	.
cord-022594-fx044gcd	743	1	A	a	DT
cord-022594-fx044gcd	743	2	small	small	JJ
cord-022594-fx044gcd	743	3	trial	trial	NN
cord-022594-fx044gcd	743	4	at	at	IN
cord-022594-fx044gcd	743	5	NIH	NIH	NNP
cord-022594-fx044gcd	743	6	showed	show	VBD
cord-022594-fx044gcd	743	7	significant	significant	JJ
cord-022594-fx044gcd	743	8	reduction	reduction	NN
cord-022594-fx044gcd	743	9	in	in	IN
cord-022594-fx044gcd	743	10	the	the	DT
cord-022594-fx044gcd	743	11	number	number	NN
cord-022594-fx044gcd	743	12	of	of	IN
cord-022594-fx044gcd	743	13	contrast	contrast	NN
cord-022594-fx044gcd	743	14	-	-	HYPH
cord-022594-fx044gcd	743	15	enhancing	enhance	VBG
cord-022594-fx044gcd	743	16	lesions	lesion	NNS
cord-022594-fx044gcd	743	17	when	when	WRB
cord-022594-fx044gcd	743	18	azathioprine	azathioprine	JJ
cord-022594-fx044gcd	743	19	in	in	IN
cord-022594-fx044gcd	743	20	an	an	DT
cord-022594-fx044gcd	743	21	average	average	JJ
cord-022594-fx044gcd	743	22	maintenance	maintenance	NN
cord-022594-fx044gcd	743	23	dose	dose	NN
cord-022594-fx044gcd	743	24	of	of	IN
cord-022594-fx044gcd	743	25	2	2	CD
cord-022594-fx044gcd	743	26	mg	mg	NNP
cord-022594-fx044gcd	743	27	/	/	SYM
cord-022594-fx044gcd	743	28	kg	kg	NNP
cord-022594-fx044gcd	743	29	/	/	SYM
cord-022594-fx044gcd	743	30	day	day	NN
cord-022594-fx044gcd	743	31	was	be	VBD
cord-022594-fx044gcd	743	32	added	add	VBN
cord-022594-fx044gcd	743	33	to	to	IN
cord-022594-fx044gcd	743	34	interferon	interferon	NN
cord-022594-fx044gcd	743	35	-	-	HYPH
cord-022594-fx044gcd	743	36	b	b	NN
cord-022594-fx044gcd	743	37	1b	1b	CD
cord-022594-fx044gcd	743	38	in	in	IN
cord-022594-fx044gcd	743	39	a	a	DT
cord-022594-fx044gcd	743	40	study	study	NN
cord-022594-fx044gcd	743	41	of	of	IN
cord-022594-fx044gcd	743	42	six	six	CD
cord-022594-fx044gcd	743	43	RRMS	rrm	NNS
cord-022594-fx044gcd	743	44	patients	patient	NNS
cord-022594-fx044gcd	743	45	followed	follow	VBD
cord-022594-fx044gcd	743	46	for	for	IN
cord-022594-fx044gcd	743	47	a	a	DT
cord-022594-fx044gcd	743	48	median	median	JJ
cord-022594-fx044gcd	743	49	period	period	NN
cord-022594-fx044gcd	743	50	of	of	IN
cord-022594-fx044gcd	743	51	15	15	CD
cord-022594-fx044gcd	743	52	months	month	NNS
cord-022594-fx044gcd	743	53	.	.	.
cord-022594-fx044gcd	744	1	The	the	DT
cord-022594-fx044gcd	744	2	addition	addition	NN
cord-022594-fx044gcd	744	3	of	of	IN
cord-022594-fx044gcd	744	4	azathioprine	azathioprine	NN
cord-022594-fx044gcd	744	5	may	may	MD
cord-022594-fx044gcd	744	6	be	be	VB
cord-022594-fx044gcd	744	7	considered	consider	VBN
cord-022594-fx044gcd	744	8	in	in	IN
cord-022594-fx044gcd	744	9	"	"	``
cord-022594-fx044gcd	744	10	treatment	treatment	NN
cord-022594-fx044gcd	744	11	failure	failure	NN
cord-022594-fx044gcd	744	12	"	"	''
cord-022594-fx044gcd	744	13	cases	case	NNS
cord-022594-fx044gcd	744	14	,	,	,
cord-022594-fx044gcd	744	15	but	but	CC
cord-022594-fx044gcd	744	16	this	this	DT
cord-022594-fx044gcd	744	17	study	study	NN
cord-022594-fx044gcd	744	18	was	be	VBD
cord-022594-fx044gcd	744	19	hampered	hamper	VBN
cord-022594-fx044gcd	744	20	by	by	IN
cord-022594-fx044gcd	744	21	the	the	DT
cord-022594-fx044gcd	744	22	small	small	JJ
cord-022594-fx044gcd	744	23	number	number	NN
cord-022594-fx044gcd	744	24	of	of	IN
cord-022594-fx044gcd	744	25	patients	patient	NNS
cord-022594-fx044gcd	744	26	,	,	,
cord-022594-fx044gcd	744	27	no	no	DT
cord-022594-fx044gcd	744	28	control	control	NN
cord-022594-fx044gcd	744	29	subjects	subject	NNS
cord-022594-fx044gcd	744	30	,	,	,
cord-022594-fx044gcd	744	31	and	and	CC
cord-022594-fx044gcd	744	32	no	no	DT
cord-022594-fx044gcd	744	33	blinding	blinding	NN
cord-022594-fx044gcd	744	34	.	.	.
cord-022594-fx044gcd	745	1	77	77	CD
cord-022594-fx044gcd	746	1	Intravenous	intravenous	JJ
cord-022594-fx044gcd	746	2	Immunoglobulin	Immunoglobulin	NNP
cord-022594-fx044gcd	746	3	.	.	.
cord-022594-fx044gcd	747	1	Monthly	monthly	JJ
cord-022594-fx044gcd	747	2	treatment	treatment	NN
cord-022594-fx044gcd	747	3	with	with	IN
cord-022594-fx044gcd	747	4	low	low	JJ
cord-022594-fx044gcd	747	5	-	-	HYPH
cord-022594-fx044gcd	747	6	dose	dose	NN
cord-022594-fx044gcd	747	7	(	(	-LRB-
cord-022594-fx044gcd	747	8	0.15	0.15	CD
cord-022594-fx044gcd	747	9	to	to	TO
cord-022594-fx044gcd	747	10	0.2	0.2	CD
cord-022594-fx044gcd	747	11	g	g	NN
cord-022594-fx044gcd	747	12	/	/	SYM
cord-022594-fx044gcd	747	13	kg	kg	NN
cord-022594-fx044gcd	747	14	)	)	-RRB-
cord-022594-fx044gcd	748	1	intravenous	intravenous	JJ
cord-022594-fx044gcd	748	2	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	748	3	(	(	-LRB-
cord-022594-fx044gcd	748	4	IVIG	IVIG	NNP
cord-022594-fx044gcd	748	5	)	)	-RRB-
cord-022594-fx044gcd	748	6	in	in	IN
cord-022594-fx044gcd	748	7	RRMS	RRMS	NNP
cord-022594-fx044gcd	748	8	patients	patient	NNS
cord-022594-fx044gcd	748	9	resulted	result	VBD
cord-022594-fx044gcd	748	10	in	in	IN
cord-022594-fx044gcd	748	11	fewer	few	JJR
cord-022594-fx044gcd	748	12	and	and	CC
cord-022594-fx044gcd	748	13	less	less	RBR
cord-022594-fx044gcd	748	14	severe	severe	JJ
cord-022594-fx044gcd	748	15	relapses	relapse	NNS
cord-022594-fx044gcd	748	16	in	in	IN
cord-022594-fx044gcd	748	17	addition	addition	NN
cord-022594-fx044gcd	748	18	to	to	IN
cord-022594-fx044gcd	748	19	slowing	slow	VBG
cord-022594-fx044gcd	748	20	the	the	DT
cord-022594-fx044gcd	748	21	accumulation	accumulation	NN
cord-022594-fx044gcd	748	22	of	of	IN
cord-022594-fx044gcd	748	23	disability	disability	NN
cord-022594-fx044gcd	748	24	in	in	IN
cord-022594-fx044gcd	748	25	a	a	DT
cord-022594-fx044gcd	748	26	single	single	JJ
cord-022594-fx044gcd	748	27	randomized	randomized	JJ
cord-022594-fx044gcd	748	28	trial	trial	NN
cord-022594-fx044gcd	748	29	.	.	.
cord-022594-fx044gcd	749	1	The	the	DT
cord-022594-fx044gcd	749	2	outcome	outcome	NN
cord-022594-fx044gcd	749	3	was	be	VBD
cord-022594-fx044gcd	749	4	similar	similar	JJ
cord-022594-fx044gcd	749	5	to	to	IN
cord-022594-fx044gcd	749	6	that	that	DT
cord-022594-fx044gcd	749	7	of	of	IN
cord-022594-fx044gcd	749	8	injectable	injectable	JJ
cord-022594-fx044gcd	749	9	interferons	interferon	NNS
cord-022594-fx044gcd	749	10	.	.	.
cord-022594-fx044gcd	750	1	78	78	CD
cord-022594-fx044gcd	751	1	This	this	DT
cord-022594-fx044gcd	751	2	therapy	therapy	NN
cord-022594-fx044gcd	751	3	is	be	VBZ
cord-022594-fx044gcd	751	4	less	less	RBR
cord-022594-fx044gcd	751	5	accepted	accept	VBN
cord-022594-fx044gcd	751	6	in	in	IN
cord-022594-fx044gcd	751	7	the	the	DT
cord-022594-fx044gcd	751	8	United	United	NNP
cord-022594-fx044gcd	751	9	States	States	NNP
cord-022594-fx044gcd	751	10	.	.	.
cord-022594-fx044gcd	752	1	More	More	JJR
cord-022594-fx044gcd	752	2	studies	study	NNS
cord-022594-fx044gcd	752	3	with	with	IN
cord-022594-fx044gcd	752	4	larger	large	JJR
cord-022594-fx044gcd	752	5	number	number	NN
cord-022594-fx044gcd	752	6	of	of	IN
cord-022594-fx044gcd	752	7	patients	patient	NNS
cord-022594-fx044gcd	752	8	and	and	CC
cord-022594-fx044gcd	752	9	extended	extended	JJ
cord-022594-fx044gcd	752	10	follow	follow	NN
cord-022594-fx044gcd	752	11	-	-	HYPH
cord-022594-fx044gcd	752	12	up	up	NN
cord-022594-fx044gcd	752	13	are	be	VBP
cord-022594-fx044gcd	752	14	needed	need	VBN
cord-022594-fx044gcd	752	15	to	to	TO
cord-022594-fx044gcd	752	16	confirm	confirm	VB
cord-022594-fx044gcd	752	17	these	these	DT
cord-022594-fx044gcd	752	18	limited	limited	JJ
cord-022594-fx044gcd	752	19	observations	observation	NNS
cord-022594-fx044gcd	752	20	.	.	.
cord-022594-fx044gcd	753	1	Recent	recent	JJ
cord-022594-fx044gcd	753	2	studies	study	NNS
cord-022594-fx044gcd	753	3	have	have	VBP
cord-022594-fx044gcd	753	4	failed	fail	VBN
cord-022594-fx044gcd	753	5	to	to	TO
cord-022594-fx044gcd	753	6	demonstrate	demonstrate	VB
cord-022594-fx044gcd	753	7	that	that	IN
cord-022594-fx044gcd	753	8	IVIG	IVIG	NNP
cord-022594-fx044gcd	753	9	administration	administration	NN
cord-022594-fx044gcd	753	10	reverses	reverse	VBZ
cord-022594-fx044gcd	753	11	long	long	RB
cord-022594-fx044gcd	753	12	-	-	HYPH
cord-022594-fx044gcd	753	13	standing	stand	VBG
cord-022594-fx044gcd	753	14	deficits	deficit	NNS
cord-022594-fx044gcd	753	15	from	from	IN
cord-022594-fx044gcd	753	16	MS	MS	NNP
cord-022594-fx044gcd	753	17	and	and	CC
cord-022594-fx044gcd	753	18	ON	ON	NNP
cord-022594-fx044gcd	753	19	.	.	.
cord-022594-fx044gcd	754	1	[	[	-LRB-
cord-022594-fx044gcd	754	2	79	79	CD
cord-022594-fx044gcd	754	3	]	]	-RRB-
cord-022594-fx044gcd	754	4	[	[	-LRB-
cord-022594-fx044gcd	754	5	80	80	CD
cord-022594-fx044gcd	754	6	]	]	-RRB-
cord-022594-fx044gcd	755	1	[	[	-LRB-
cord-022594-fx044gcd	755	2	81	81	CD
cord-022594-fx044gcd	755	3	]	]	-RRB-
cord-022594-fx044gcd	755	4	IVIG	IVIG	NNP
cord-022594-fx044gcd	755	5	was	be	VBD
cord-022594-fx044gcd	755	6	also	also	RB
cord-022594-fx044gcd	755	7	recently	recently	RB
cord-022594-fx044gcd	755	8	studied	study	VBN
cord-022594-fx044gcd	755	9	in	in	IN
cord-022594-fx044gcd	755	10	acute	acute	JJ
cord-022594-fx044gcd	755	11	ON	ON	NNP
cord-022594-fx044gcd	755	12	and	and	CC
cord-022594-fx044gcd	755	13	failed	fail	VBD
cord-022594-fx044gcd	755	14	to	to	TO
cord-022594-fx044gcd	755	15	demonstrate	demonstrate	VB
cord-022594-fx044gcd	755	16	benefit	benefit	NN
cord-022594-fx044gcd	755	17	on	on	IN
cord-022594-fx044gcd	755	18	any	any	DT
cord-022594-fx044gcd	755	19	of	of	IN
cord-022594-fx044gcd	755	20	the	the	DT
cord-022594-fx044gcd	755	21	outcome	outcome	NN
cord-022594-fx044gcd	755	22	measures	measure	NNS
cord-022594-fx044gcd	755	23	.	.	.
cord-022594-fx044gcd	756	1	82	82	CD
cord-022594-fx044gcd	756	2	Natalizumab	Natalizumab	NNS
cord-022594-fx044gcd	756	3	.	.	.
cord-022594-fx044gcd	757	1	In	in	IN
cord-022594-fx044gcd	757	2	late	late	JJ
cord-022594-fx044gcd	757	3	2004	2004	CD
cord-022594-fx044gcd	757	4	,	,	,
cord-022594-fx044gcd	757	5	natalizumab	natalizumab	NNP
cord-022594-fx044gcd	757	6	was	be	VBD
cord-022594-fx044gcd	757	7	approved	approve	VBN
cord-022594-fx044gcd	757	8	for	for	IN
cord-022594-fx044gcd	757	9	the	the	DT
cord-022594-fx044gcd	757	10	treatment	treatment	NN
cord-022594-fx044gcd	757	11	of	of	IN
cord-022594-fx044gcd	757	12	RRMS	RRMS	NNP
cord-022594-fx044gcd	757	13	.	.	.
cord-022594-fx044gcd	758	1	83	83	CD
cord-022594-fx044gcd	759	1	Natalizumab	Natalizumab	NNP
cord-022594-fx044gcd	759	2	is	be	VBZ
cord-022594-fx044gcd	759	3	a	a	DT
cord-022594-fx044gcd	759	4	humanized	humanize	VBN
cord-022594-fx044gcd	759	5	a-4	a-4	NN
cord-022594-fx044gcd	759	6	integrin	integrin	NN
cord-022594-fx044gcd	759	7	antibody	antibody	NN
cord-022594-fx044gcd	759	8	that	that	WDT
cord-022594-fx044gcd	759	9	inhibits	inhibit	VBZ
cord-022594-fx044gcd	759	10	the	the	DT
cord-022594-fx044gcd	759	11	migration	migration	NN
cord-022594-fx044gcd	759	12	of	of	IN
cord-022594-fx044gcd	759	13	all	all	DT
cord-022594-fx044gcd	759	14	leukocytes	leukocyte	NNS
cord-022594-fx044gcd	759	15	(	(	-LRB-
cord-022594-fx044gcd	759	16	except	except	IN
cord-022594-fx044gcd	759	17	for	for	IN
cord-022594-fx044gcd	759	18	neutrophils	neutrophil	NNS
cord-022594-fx044gcd	759	19	)	)	-RRB-
cord-022594-fx044gcd	759	20	to	to	TO
cord-022594-fx044gcd	759	21	target	target	VB
cord-022594-fx044gcd	759	22	organs	organ	NNS
cord-022594-fx044gcd	759	23	.	.	.
cord-022594-fx044gcd	760	1	A	a	DT
cord-022594-fx044gcd	760	2	phase	phase	NN
cord-022594-fx044gcd	760	3	2	2	CD
cord-022594-fx044gcd	760	4	study	study	NN
cord-022594-fx044gcd	760	5	established	establish	VBD
cord-022594-fx044gcd	760	6	84	84	CD
cord-022594-fx044gcd	760	7	that	that	IN
cord-022594-fx044gcd	760	8	a	a	DT
cord-022594-fx044gcd	760	9	300-mg	300-mg	CD
cord-022594-fx044gcd	760	10	monthly	monthly	JJ
cord-022594-fx044gcd	760	11	dose	dose	NN
cord-022594-fx044gcd	760	12	reduced	reduce	VBD
cord-022594-fx044gcd	760	13	the	the	DT
cord-022594-fx044gcd	760	14	number	number	NN
cord-022594-fx044gcd	760	15	of	of	IN
cord-022594-fx044gcd	760	16	gadolinium	gadolinium	NN
cord-022594-fx044gcd	760	17	-	-	HYPH
cord-022594-fx044gcd	760	18	enhancing	enhance	VBG
cord-022594-fx044gcd	760	19	lesions	lesion	NNS
cord-022594-fx044gcd	760	20	by	by	IN
cord-022594-fx044gcd	760	21	90	90	CD
cord-022594-fx044gcd	760	22	%	%	NN
cord-022594-fx044gcd	760	23	and	and	CC
cord-022594-fx044gcd	760	24	the	the	DT
cord-022594-fx044gcd	760	25	clinical	clinical	JJ
cord-022594-fx044gcd	760	26	relapse	relapse	NN
cord-022594-fx044gcd	760	27	rate	rate	NN
cord-022594-fx044gcd	760	28	by	by	IN
cord-022594-fx044gcd	760	29	over	over	IN
cord-022594-fx044gcd	760	30	50	50	CD
cord-022594-fx044gcd	760	31	%	%	NN
cord-022594-fx044gcd	760	32	compared	compare	VBN
cord-022594-fx044gcd	760	33	to	to	IN
cord-022594-fx044gcd	760	34	placebo	placebo	NN
cord-022594-fx044gcd	760	35	.	.	.
cord-022594-fx044gcd	761	1	This	this	DT
cord-022594-fx044gcd	761	2	study	study	NN
cord-022594-fx044gcd	761	3	was	be	VBD
cord-022594-fx044gcd	761	4	followed	follow	VBN
cord-022594-fx044gcd	761	5	by	by	IN
cord-022594-fx044gcd	761	6	the	the	DT
cord-022594-fx044gcd	761	7	AFFIRM	AFFIRM	NNP
cord-022594-fx044gcd	761	8	and	and	CC
cord-022594-fx044gcd	761	9	SENTINEL	SENTINEL	NNP
cord-022594-fx044gcd	761	10	phase	phase	NN
cord-022594-fx044gcd	761	11	III	iii	CD
cord-022594-fx044gcd	761	12	studies	study	NNS
cord-022594-fx044gcd	761	13	.	.	.
cord-022594-fx044gcd	762	1	The	the	DT
cord-022594-fx044gcd	762	2	AFFIRM	affirm	JJ
cord-022594-fx044gcd	762	3	study	study	NN
cord-022594-fx044gcd	762	4	enrolled	enrol	VBD
cord-022594-fx044gcd	762	5	over	over	IN
cord-022594-fx044gcd	762	6	900	900	CD
cord-022594-fx044gcd	762	7	patients	patient	NNS
cord-022594-fx044gcd	762	8	with	with	IN
cord-022594-fx044gcd	762	9	RRMS	RRMS	NNP
cord-022594-fx044gcd	762	10	;	;	:
cord-022594-fx044gcd	762	11	none	none	NN
cord-022594-fx044gcd	762	12	of	of	IN
cord-022594-fx044gcd	762	13	them	-PRON-	PRP
cord-022594-fx044gcd	762	14	had	have	VBD
cord-022594-fx044gcd	762	15	been	be	VBN
cord-022594-fx044gcd	762	16	on	on	IN
cord-022594-fx044gcd	762	17	other	other	JJ
cord-022594-fx044gcd	762	18	approved	approve	VBN
cord-022594-fx044gcd	762	19	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	762	20	for	for	IN
cord-022594-fx044gcd	762	21	longer	long	JJR
cord-022594-fx044gcd	762	22	than	than	IN
cord-022594-fx044gcd	762	23	6	6	CD
cord-022594-fx044gcd	762	24	months	month	NNS
cord-022594-fx044gcd	762	25	.	.	.
cord-022594-fx044gcd	763	1	The	the	DT
cord-022594-fx044gcd	763	2	annualized	annualize	VBN
cord-022594-fx044gcd	763	3	relapse	relapse	NN
cord-022594-fx044gcd	763	4	rate	rate	NN
cord-022594-fx044gcd	763	5	at	at	IN
cord-022594-fx044gcd	763	6	1	1	CD
cord-022594-fx044gcd	763	7	year	year	NN
cord-022594-fx044gcd	763	8	was	be	VBD
cord-022594-fx044gcd	763	9	reduced	reduce	VBN
cord-022594-fx044gcd	763	10	from	from	IN
cord-022594-fx044gcd	763	11	0.74	0.74	CD
cord-022594-fx044gcd	763	12	in	in	IN
cord-022594-fx044gcd	763	13	the	the	DT
cord-022594-fx044gcd	763	14	placebo	placebo	NN
cord-022594-fx044gcd	763	15	group	group	NN
cord-022594-fx044gcd	763	16	to	to	IN
cord-022594-fx044gcd	763	17	0.25	0.25	CD
cord-022594-fx044gcd	763	18	in	in	IN
cord-022594-fx044gcd	763	19	the	the	DT
cord-022594-fx044gcd	763	20	treated	treated	JJ
cord-022594-fx044gcd	763	21	group	group	NN
cord-022594-fx044gcd	763	22	(	(	-LRB-
cord-022594-fx044gcd	763	23	66	66	CD
cord-022594-fx044gcd	763	24	%	%	NN
cord-022594-fx044gcd	763	25	relative	relative	JJ
cord-022594-fx044gcd	763	26	reduction	reduction	NN
cord-022594-fx044gcd	763	27	,	,	,
cord-022594-fx044gcd	763	28	p	p	NN
cord-022594-fx044gcd	763	29	<	<	XX
cord-022594-fx044gcd	763	30	0.0001	0.0001	CD
cord-022594-fx044gcd	763	31	)	)	-RRB-
cord-022594-fx044gcd	763	32	.	.	.
cord-022594-fx044gcd	764	1	The	the	DT
cord-022594-fx044gcd	764	2	proportion	proportion	NN
cord-022594-fx044gcd	764	3	of	of	IN
cord-022594-fx044gcd	764	4	relapse	relapse	NN
cord-022594-fx044gcd	764	5	-	-	HYPH
cord-022594-fx044gcd	764	6	free	free	JJ
cord-022594-fx044gcd	764	7	patients	patient	NNS
cord-022594-fx044gcd	764	8	was	be	VBD
cord-022594-fx044gcd	764	9	76	76	CD
cord-022594-fx044gcd	764	10	%	%	NN
cord-022594-fx044gcd	764	11	in	in	IN
cord-022594-fx044gcd	764	12	the	the	DT
cord-022594-fx044gcd	764	13	treated	treated	JJ
cord-022594-fx044gcd	764	14	group	group	NN
cord-022594-fx044gcd	764	15	,	,	,
cord-022594-fx044gcd	764	16	53	53	CD
cord-022594-fx044gcd	764	17	%	%	NN
cord-022594-fx044gcd	764	18	in	in	IN
cord-022594-fx044gcd	764	19	the	the	DT
cord-022594-fx044gcd	764	20	placebo	placebo	NN
cord-022594-fx044gcd	764	21	group	group	NN
cord-022594-fx044gcd	764	22	.	.	.
cord-022594-fx044gcd	765	1	The	the	DT
cord-022594-fx044gcd	765	2	number	number	NN
cord-022594-fx044gcd	765	3	of	of	IN
cord-022594-fx044gcd	765	4	enhancing	enhance	VBG
cord-022594-fx044gcd	765	5	lesions	lesion	NNS
cord-022594-fx044gcd	765	6	was	be	VBD
cord-022594-fx044gcd	765	7	reduced	reduce	VBN
cord-022594-fx044gcd	765	8	by	by	IN
cord-022594-fx044gcd	765	9	92	92	CD
cord-022594-fx044gcd	765	10	%	%	NN
cord-022594-fx044gcd	765	11	,	,	,
cord-022594-fx044gcd	765	12	and	and	CC
cord-022594-fx044gcd	765	13	the	the	DT
cord-022594-fx044gcd	765	14	number	number	NN
cord-022594-fx044gcd	765	15	of	of	IN
cord-022594-fx044gcd	765	16	new	new	JJ
cord-022594-fx044gcd	765	17	or	or	CC
cord-022594-fx044gcd	765	18	newly	newly	RB
cord-022594-fx044gcd	765	19	enlarging	enlarge	VBG
cord-022594-fx044gcd	765	20	T2	T2	NNP
cord-022594-fx044gcd	765	21	lesions	lesion	NNS
cord-022594-fx044gcd	765	22	was	be	VBD
cord-022594-fx044gcd	765	23	reduced	reduce	VBN
cord-022594-fx044gcd	765	24	by	by	IN
cord-022594-fx044gcd	765	25	80	80	CD
cord-022594-fx044gcd	765	26	%	%	NN
cord-022594-fx044gcd	765	27	.	.	.
cord-022594-fx044gcd	766	1	The	the	DT
cord-022594-fx044gcd	766	2	proportion	proportion	NN
cord-022594-fx044gcd	766	3	of	of	IN
cord-022594-fx044gcd	766	4	patients	patient	NNS
cord-022594-fx044gcd	766	5	without	without	IN
cord-022594-fx044gcd	766	6	clinical	clinical	JJ
cord-022594-fx044gcd	766	7	and	and	CC
cord-022594-fx044gcd	766	8	MRI	MRI	NNP
cord-022594-fx044gcd	766	9	activity	activity	NN
cord-022594-fx044gcd	766	10	was	be	VBD
cord-022594-fx044gcd	766	11	46	46	CD
cord-022594-fx044gcd	766	12	%	%	NN
cord-022594-fx044gcd	766	13	in	in	IN
cord-022594-fx044gcd	766	14	the	the	DT
cord-022594-fx044gcd	766	15	natalizumab	natalizumab	NNP
cord-022594-fx044gcd	766	16	group	group	NN
cord-022594-fx044gcd	766	17	,	,	,
cord-022594-fx044gcd	766	18	and	and	CC
cord-022594-fx044gcd	766	19	14	14	CD
cord-022594-fx044gcd	766	20	%	%	NN
cord-022594-fx044gcd	766	21	in	in	IN
cord-022594-fx044gcd	766	22	the	the	DT
cord-022594-fx044gcd	766	23	placebo	placebo	NN
cord-022594-fx044gcd	766	24	group	group	NN
cord-022594-fx044gcd	766	25	.	.	.
cord-022594-fx044gcd	767	1	In	in	IN
cord-022594-fx044gcd	767	2	the	the	DT
cord-022594-fx044gcd	767	3	SENTINEL	SENTINEL	NNP
cord-022594-fx044gcd	767	4	trial	trial	NN
cord-022594-fx044gcd	767	5	,	,	,
cord-022594-fx044gcd	767	6	the	the	DT
cord-022594-fx044gcd	767	7	combination	combination	NN
cord-022594-fx044gcd	767	8	of	of	IN
cord-022594-fx044gcd	767	9	intramuscular	intramuscular	JJ
cord-022594-fx044gcd	767	10	interferon	interferon	NN
cord-022594-fx044gcd	767	11	-	-	HYPH
cord-022594-fx044gcd	767	12	b	b	NN
cord-022594-fx044gcd	767	13	1a	1a	CD
cord-022594-fx044gcd	767	14	and	and	CC
cord-022594-fx044gcd	767	15	natalizumab	natalizumab	NNP
cord-022594-fx044gcd	767	16	was	be	VBD
cord-022594-fx044gcd	767	17	studied	study	VBN
cord-022594-fx044gcd	767	18	against	against	IN
cord-022594-fx044gcd	767	19	IM	IM	NNP
cord-022594-fx044gcd	767	20	interferon	interferon	NN
cord-022594-fx044gcd	767	21	-	-	HYPH
cord-022594-fx044gcd	767	22	b	b	NN
cord-022594-fx044gcd	767	23	1a	1a	CD
cord-022594-fx044gcd	767	24	and	and	CC
cord-022594-fx044gcd	767	25	placebo	placebo	NN
cord-022594-fx044gcd	767	26	in	in	IN
cord-022594-fx044gcd	767	27	patients	patient	NNS
cord-022594-fx044gcd	767	28	who	who	WP
cord-022594-fx044gcd	767	29	had	have	VBD
cord-022594-fx044gcd	767	30	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	767	31	an	an	DT
cord-022594-fx044gcd	767	32	incomplete	incomplete	JJ
cord-022594-fx044gcd	767	33	response	response	NN
cord-022594-fx044gcd	767	34	(	(	-LRB-
cord-022594-fx044gcd	767	35	relapse	relapse	NN
cord-022594-fx044gcd	767	36	suppression	suppression	NN
cord-022594-fx044gcd	767	37	)	)	-RRB-
cord-022594-fx044gcd	767	38	to	to	IN
cord-022594-fx044gcd	767	39	interferon	interferon	NN
cord-022594-fx044gcd	767	40	therapy	therapy	NN
cord-022594-fx044gcd	767	41	.	.	.
cord-022594-fx044gcd	768	1	The	the	DT
cord-022594-fx044gcd	768	2	EBM	EBM	NNP
cord-022594-fx044gcd	768	3	calculations	calculation	NNS
cord-022594-fx044gcd	768	4	of	of	IN
cord-022594-fx044gcd	768	5	the	the	DT
cord-022594-fx044gcd	768	6	AFFIRM	AFFIRM	NNP
cord-022594-fx044gcd	768	7	data	datum	NNS
cord-022594-fx044gcd	768	8	based	base	VBN
cord-022594-fx044gcd	768	9	on	on	IN
cord-022594-fx044gcd	768	10	proportion	proportion	NN
cord-022594-fx044gcd	768	11	with	with	IN
cord-022594-fx044gcd	768	12	relapses	relapse	NNS
cord-022594-fx044gcd	768	13	suggests	suggest	VBZ
cord-022594-fx044gcd	768	14	an	an	DT
cord-022594-fx044gcd	768	15	RRR	RRR	NNP
cord-022594-fx044gcd	768	16	of	of	IN
cord-022594-fx044gcd	768	17	49	49	CD
cord-022594-fx044gcd	768	18	%	%	NN
cord-022594-fx044gcd	768	19	,	,	,
cord-022594-fx044gcd	768	20	an	an	DT
cord-022594-fx044gcd	768	21	ARR	arr	NN
cord-022594-fx044gcd	768	22	of	of	IN
cord-022594-fx044gcd	768	23	23	23	CD
cord-022594-fx044gcd	768	24	%	%	NN
cord-022594-fx044gcd	768	25	,	,	,
cord-022594-fx044gcd	768	26	and	and	CC
cord-022594-fx044gcd	768	27	an	an	DT
cord-022594-fx044gcd	768	28	NNT	nnt	NN
cord-022594-fx044gcd	768	29	of	of	IN
cord-022594-fx044gcd	768	30	4	4	CD
cord-022594-fx044gcd	768	31	over	over	IN
cord-022594-fx044gcd	768	32	1	1	CD
cord-022594-fx044gcd	768	33	year	year	NN
cord-022594-fx044gcd	768	34	to	to	TO
cord-022594-fx044gcd	768	35	increase	increase	VB
cord-022594-fx044gcd	768	36	the	the	DT
cord-022594-fx044gcd	768	37	proportion	proportion	NN
cord-022594-fx044gcd	768	38	of	of	IN
cord-022594-fx044gcd	768	39	relapse	relapse	NN
cord-022594-fx044gcd	768	40	free	free	JJ
cord-022594-fx044gcd	768	41	by	by	IN
cord-022594-fx044gcd	768	42	one	one	CD
cord-022594-fx044gcd	768	43	.	.	.
cord-022594-fx044gcd	769	1	The	the	DT
cord-022594-fx044gcd	769	2	SENTI	SENTI	NNP
cord-022594-fx044gcd	769	3	-	-	HYPH
cord-022594-fx044gcd	769	4	NEL	NEL	NNP
cord-022594-fx044gcd	769	5	data	datum	NNS
cord-022594-fx044gcd	769	6	shows	show	VBZ
cord-022594-fx044gcd	769	7	an	an	DT
cord-022594-fx044gcd	769	8	RRR	RRR	NNP
cord-022594-fx044gcd	769	9	of	of	IN
cord-022594-fx044gcd	769	10	31	31	CD
cord-022594-fx044gcd	769	11	%	%	NN
cord-022594-fx044gcd	769	12	,	,	,
cord-022594-fx044gcd	769	13	an	an	DT
cord-022594-fx044gcd	769	14	ARR	arr	NN
cord-022594-fx044gcd	769	15	of	of	IN
cord-022594-fx044gcd	769	16	17	17	CD
cord-022594-fx044gcd	769	17	%	%	NN
cord-022594-fx044gcd	769	18	,	,	,
cord-022594-fx044gcd	769	19	and	and	CC
cord-022594-fx044gcd	769	20	an	an	DT
cord-022594-fx044gcd	769	21	NNT	nnt	NN
cord-022594-fx044gcd	769	22	of	of	IN
cord-022594-fx044gcd	769	23	6	6	CD
cord-022594-fx044gcd	769	24	over	over	IN
cord-022594-fx044gcd	769	25	1	1	CD
cord-022594-fx044gcd	769	26	year	year	NN
cord-022594-fx044gcd	769	27	to	to	TO
cord-022594-fx044gcd	769	28	increase	increase	VB
cord-022594-fx044gcd	769	29	the	the	DT
cord-022594-fx044gcd	769	30	proportion	proportion	NN
cord-022594-fx044gcd	769	31	relapse	relapse	VB
cord-022594-fx044gcd	769	32	free	free	JJ
cord-022594-fx044gcd	769	33	.	.	.
cord-022594-fx044gcd	770	1	The	the	DT
cord-022594-fx044gcd	770	2	original	original	JJ
cord-022594-fx044gcd	770	3	pilot	pilot	NN
cord-022594-fx044gcd	770	4	trial	trial	NN
cord-022594-fx044gcd	770	5	data	datum	NNS
cord-022594-fx044gcd	770	6	shows	show	VBZ
cord-022594-fx044gcd	770	7	a	a	DT
cord-022594-fx044gcd	770	8	RRR	RRR	NNP
cord-022594-fx044gcd	770	9	of	of	IN
cord-022594-fx044gcd	770	10	50	50	CD
cord-022594-fx044gcd	770	11	%	%	NN
cord-022594-fx044gcd	770	12	and	and	CC
cord-022594-fx044gcd	770	13	an	an	DT
cord-022594-fx044gcd	770	14	ARR	arr	NN
cord-022594-fx044gcd	770	15	of	of	IN
cord-022594-fx044gcd	770	16	19	19	CD
cord-022594-fx044gcd	770	17	%	%	NN
cord-022594-fx044gcd	770	18	,	,	,
cord-022594-fx044gcd	770	19	with	with	IN
cord-022594-fx044gcd	770	20	an	an	DT
cord-022594-fx044gcd	770	21	NNT	nnt	NN
cord-022594-fx044gcd	770	22	of	of	IN
cord-022594-fx044gcd	770	23	5	5	CD
cord-022594-fx044gcd	770	24	over	over	IN
cord-022594-fx044gcd	770	25	6	6	CD
cord-022594-fx044gcd	770	26	months	month	NNS
cord-022594-fx044gcd	770	27	to	to	TO
cord-022594-fx044gcd	770	28	increase	increase	VB
cord-022594-fx044gcd	770	29	the	the	DT
cord-022594-fx044gcd	770	30	proportion	proportion	NN
cord-022594-fx044gcd	770	31	relapse	relapse	VB
cord-022594-fx044gcd	770	32	free	free	JJ
cord-022594-fx044gcd	770	33	.	.	.
cord-022594-fx044gcd	771	1	Based	base	VBN
cord-022594-fx044gcd	771	2	on	on	IN
cord-022594-fx044gcd	771	3	these	these	DT
cord-022594-fx044gcd	771	4	data	datum	NNS
cord-022594-fx044gcd	771	5	,	,	,
cord-022594-fx044gcd	771	6	the	the	DT
cord-022594-fx044gcd	771	7	FDA	FDA	NNP
cord-022594-fx044gcd	771	8	granted	grant	VBD
cord-022594-fx044gcd	771	9	expedited	expedited	JJ
cord-022594-fx044gcd	771	10	approval	approval	NN
cord-022594-fx044gcd	771	11	of	of	IN
cord-022594-fx044gcd	771	12	natalizumab	natalizumab	NNS
cord-022594-fx044gcd	771	13	on	on	IN
cord-022594-fx044gcd	771	14	November	November	NNP
cord-022594-fx044gcd	771	15	23	23	CD
cord-022594-fx044gcd	771	16	,	,	,
cord-022594-fx044gcd	771	17	2004	2004	CD
cord-022594-fx044gcd	771	18	.	.	.
cord-022594-fx044gcd	772	1	On	on	IN
cord-022594-fx044gcd	772	2	February	February	NNP
cord-022594-fx044gcd	772	3	28	28	CD
cord-022594-fx044gcd	772	4	,	,	,
cord-022594-fx044gcd	772	5	2005	2005	CD
cord-022594-fx044gcd	772	6	,	,	,
cord-022594-fx044gcd	772	7	the	the	DT
cord-022594-fx044gcd	772	8	medication	medication	NN
cord-022594-fx044gcd	772	9	was	be	VBD
cord-022594-fx044gcd	772	10	voluntarily	voluntarily	RB
cord-022594-fx044gcd	772	11	withdrawn	withdraw	VBN
cord-022594-fx044gcd	772	12	from	from	IN
cord-022594-fx044gcd	772	13	the	the	DT
cord-022594-fx044gcd	772	14	market	market	NN
cord-022594-fx044gcd	772	15	by	by	IN
cord-022594-fx044gcd	772	16	the	the	DT
cord-022594-fx044gcd	772	17	sponsor	sponsor	NN
cord-022594-fx044gcd	772	18	(	(	-LRB-
cord-022594-fx044gcd	772	19	Biogen	Biogen	NNP
cord-022594-fx044gcd	772	20	-	-	HYPH
cord-022594-fx044gcd	772	21	Elan	Elan	NNP
cord-022594-fx044gcd	772	22	)	)	-RRB-
cord-022594-fx044gcd	772	23	after	after	IN
cord-022594-fx044gcd	772	24	two	two	CD
cord-022594-fx044gcd	772	25	cases	case	NNS
cord-022594-fx044gcd	772	26	of	of	IN
cord-022594-fx044gcd	772	27	progressive	progressive	JJ
cord-022594-fx044gcd	772	28	multifocal	multifocal	JJ
cord-022594-fx044gcd	772	29	leukoencephalopathy	leukoencephalopathy	NNS
cord-022594-fx044gcd	772	30	(	(	-LRB-
cord-022594-fx044gcd	772	31	PML	PML	NNP
cord-022594-fx044gcd	772	32	)	)	-RRB-
cord-022594-fx044gcd	772	33	were	be	VBD
cord-022594-fx044gcd	772	34	reported	report	VBN
cord-022594-fx044gcd	772	35	in	in	IN
cord-022594-fx044gcd	772	36	the	the	DT
cord-022594-fx044gcd	772	37	SENTINEL	SENTINEL	NNP
cord-022594-fx044gcd	772	38	study	study	NN
cord-022594-fx044gcd	772	39	cohort	cohort	NN
cord-022594-fx044gcd	772	40	.	.	.
cord-022594-fx044gcd	773	1	85	85	CD
cord-022594-fx044gcd	774	1	Both	both	DT
cord-022594-fx044gcd	774	2	patients	patient	NNS
cord-022594-fx044gcd	774	3	were	be	VBD
cord-022594-fx044gcd	774	4	in	in	IN
cord-022594-fx044gcd	774	5	the	the	DT
cord-022594-fx044gcd	774	6	combined	combine	VBN
cord-022594-fx044gcd	774	7	interferon	interferon	NN
cord-022594-fx044gcd	774	8	and	and	CC
cord-022594-fx044gcd	774	9	natalizumab	natalizumab	NNP
cord-022594-fx044gcd	774	10	arm	arm	NN
cord-022594-fx044gcd	774	11	.	.	.
cord-022594-fx044gcd	775	1	A	a	DT
cord-022594-fx044gcd	775	2	third	third	JJ
cord-022594-fx044gcd	775	3	PML	PML	NNP
cord-022594-fx044gcd	775	4	case	case	NN
cord-022594-fx044gcd	775	5	was	be	VBD
cord-022594-fx044gcd	775	6	later	later	RB
cord-022594-fx044gcd	775	7	identified	identify	VBN
cord-022594-fx044gcd	775	8	from	from	IN
cord-022594-fx044gcd	775	9	one	one	CD
cord-022594-fx044gcd	775	10	of	of	IN
cord-022594-fx044gcd	775	11	the	the	DT
cord-022594-fx044gcd	775	12	phase	phase	NN
cord-022594-fx044gcd	775	13	III	iii	CD
cord-022594-fx044gcd	775	14	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	775	15	bowel	bowel	NN
cord-022594-fx044gcd	775	16	trials	trial	NNS
cord-022594-fx044gcd	775	17	of	of	IN
cord-022594-fx044gcd	775	18	this	this	DT
cord-022594-fx044gcd	775	19	agent	agent	NN
cord-022594-fx044gcd	775	20	.	.	.
cord-022594-fx044gcd	776	1	At	at	IN
cord-022594-fx044gcd	776	2	the	the	DT
cord-022594-fx044gcd	776	3	time	time	NN
cord-022594-fx044gcd	776	4	of	of	IN
cord-022594-fx044gcd	776	5	writing	write	VBG
cord-022594-fx044gcd	776	6	this	this	DT
cord-022594-fx044gcd	776	7	manuscript	manuscript	NN
cord-022594-fx044gcd	776	8	,	,	,
cord-022594-fx044gcd	776	9	natalizumab	natalizumab	NNP
cord-022594-fx044gcd	776	10	is	be	VBZ
cord-022594-fx044gcd	776	11	still	still	RB
cord-022594-fx044gcd	776	12	off	off	IN
cord-022594-fx044gcd	776	13	the	the	DT
cord-022594-fx044gcd	776	14	market	market	NN
cord-022594-fx044gcd	776	15	.	.	.
cord-022594-fx044gcd	777	1	The	the	DT
cord-022594-fx044gcd	777	2	natalizumab	natalizumab	JJ
cord-022594-fx044gcd	777	3	story	story	NN
cord-022594-fx044gcd	777	4	has	have	VBZ
cord-022594-fx044gcd	777	5	received	receive	VBN
cord-022594-fx044gcd	777	6	significant	significant	JJ
cord-022594-fx044gcd	777	7	media	medium	NNS
cord-022594-fx044gcd	777	8	attention	attention	NN
cord-022594-fx044gcd	777	9	.	.	.
cord-022594-fx044gcd	778	1	Several	several	JJ
cord-022594-fx044gcd	778	2	consequences	consequence	NNS
cord-022594-fx044gcd	778	3	can	can	MD
cord-022594-fx044gcd	778	4	be	be	VB
cord-022594-fx044gcd	778	5	drawn	draw	VBN
cord-022594-fx044gcd	778	6	from	from	IN
cord-022594-fx044gcd	778	7	this	this	DT
cord-022594-fx044gcd	778	8	failure	failure	NN
cord-022594-fx044gcd	778	9	.	.	.
cord-022594-fx044gcd	779	1	First	first	RB
cord-022594-fx044gcd	779	2	,	,	,
cord-022594-fx044gcd	779	3	highly	highly	RB
cord-022594-fx044gcd	779	4	potent	potent	JJ
cord-022594-fx044gcd	779	5	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	779	6	like	like	IN
cord-022594-fx044gcd	779	7	natalizumab	natalizumab	NNS
cord-022594-fx044gcd	779	8	are	be	VBP
cord-022594-fx044gcd	779	9	best	well	RBS
cord-022594-fx044gcd	779	10	used	use	VBN
cord-022594-fx044gcd	779	11	by	by	IN
cord-022594-fx044gcd	779	12	specialists	specialist	NNS
cord-022594-fx044gcd	779	13	in	in	IN
cord-022594-fx044gcd	779	14	selected	select	VBN
cord-022594-fx044gcd	779	15	cases	case	NNS
cord-022594-fx044gcd	779	16	.	.	.
cord-022594-fx044gcd	780	1	A	a	DT
cord-022594-fx044gcd	780	2	large	large	JJ
cord-022594-fx044gcd	780	3	number	number	NN
cord-022594-fx044gcd	780	4	of	of	IN
cord-022594-fx044gcd	780	5	prescriptions	prescription	NNS
cord-022594-fx044gcd	780	6	were	be	VBD
cord-022594-fx044gcd	780	7	written	write	VBN
cord-022594-fx044gcd	780	8	for	for	IN
cord-022594-fx044gcd	780	9	natalizumab	natalizumab	NNS
cord-022594-fx044gcd	780	10	during	during	IN
cord-022594-fx044gcd	780	11	its	-PRON-	PRP$
cord-022594-fx044gcd	780	12	short	short	JJ
cord-022594-fx044gcd	780	13	3	3	CD
cord-022594-fx044gcd	780	14	months	month	NNS
cord-022594-fx044gcd	780	15	on	on	IN
cord-022594-fx044gcd	780	16	the	the	DT
cord-022594-fx044gcd	780	17	market	market	NN
cord-022594-fx044gcd	780	18	,	,	,
cord-022594-fx044gcd	780	19	including	include	VBG
cord-022594-fx044gcd	780	20	prescriptions	prescription	NNS
cord-022594-fx044gcd	780	21	by	by	IN
cord-022594-fx044gcd	780	22	general	general	JJ
cord-022594-fx044gcd	780	23	practitioners	practitioner	NNS
cord-022594-fx044gcd	780	24	.	.	.
cord-022594-fx044gcd	781	1	Widespread	widespread	JJ
cord-022594-fx044gcd	781	2	use	use	NN
cord-022594-fx044gcd	781	3	of	of	IN
cord-022594-fx044gcd	781	4	such	such	JJ
cord-022594-fx044gcd	781	5	medication	medication	NN
cord-022594-fx044gcd	781	6	in	in	IN
cord-022594-fx044gcd	781	7	relatively	relatively	RB
cord-022594-fx044gcd	781	8	stable	stable	JJ
cord-022594-fx044gcd	781	9	cases	case	NNS
cord-022594-fx044gcd	781	10	of	of	IN
cord-022594-fx044gcd	781	11	MS	MS	NNP
cord-022594-fx044gcd	781	12	is	be	VBZ
cord-022594-fx044gcd	781	13	not	not	RB
cord-022594-fx044gcd	781	14	indicated	indicate	VBN
cord-022594-fx044gcd	781	15	.	.	.
cord-022594-fx044gcd	782	1	Second	second	RB
cord-022594-fx044gcd	782	2	,	,	,
cord-022594-fx044gcd	782	3	the	the	DT
cord-022594-fx044gcd	782	4	combination	combination	NN
cord-022594-fx044gcd	782	5	of	of	IN
cord-022594-fx044gcd	782	6	potent	potent	JJ
cord-022594-fx044gcd	782	7	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	782	8	may	may	MD
cord-022594-fx044gcd	782	9	result	result	VB
cord-022594-fx044gcd	782	10	in	in	IN
cord-022594-fx044gcd	782	11	unpredictable	unpredictable	JJ
cord-022594-fx044gcd	782	12	adverse	adverse	JJ
cord-022594-fx044gcd	782	13	outcomes	outcome	NNS
cord-022594-fx044gcd	782	14	.	.	.
cord-022594-fx044gcd	783	1	Many	many	JJ
cord-022594-fx044gcd	783	2	MS	MS	NNP
cord-022594-fx044gcd	783	3	experts	expert	NNS
cord-022594-fx044gcd	783	4	anticipate	anticipate	VBP
cord-022594-fx044gcd	783	5	that	that	IN
cord-022594-fx044gcd	783	6	in	in	IN
cord-022594-fx044gcd	783	7	the	the	DT
cord-022594-fx044gcd	783	8	future	future	JJ
cord-022594-fx044gcd	783	9	MS	MS	NNP
cord-022594-fx044gcd	783	10	therapies	therapy	NNS
cord-022594-fx044gcd	783	11	will	will	MD
cord-022594-fx044gcd	783	12	need	need	VB
cord-022594-fx044gcd	783	13	to	to	TO
cord-022594-fx044gcd	783	14	be	be	VB
cord-022594-fx044gcd	783	15	administered	administer	VBN
cord-022594-fx044gcd	783	16	in	in	IN
cord-022594-fx044gcd	783	17	combination	combination	NN
cord-022594-fx044gcd	783	18	to	to	TO
cord-022594-fx044gcd	783	19	optimize	optimize	VB
cord-022594-fx044gcd	783	20	therapeutic	therapeutic	JJ
cord-022594-fx044gcd	783	21	benefit	benefit	NN
cord-022594-fx044gcd	783	22	.	.	.
cord-022594-fx044gcd	784	1	However	however	RB
cord-022594-fx044gcd	784	2	,	,	,
cord-022594-fx044gcd	784	3	the	the	DT
cord-022594-fx044gcd	784	4	exact	exact	JJ
cord-022594-fx044gcd	784	5	effect	effect	NN
cord-022594-fx044gcd	784	6	of	of	IN
cord-022594-fx044gcd	784	7	such	such	JJ
cord-022594-fx044gcd	784	8	combinations	combination	NNS
cord-022594-fx044gcd	784	9	on	on	IN
cord-022594-fx044gcd	784	10	the	the	DT
cord-022594-fx044gcd	784	11	highly	highly	RB
cord-022594-fx044gcd	784	12	complex	complex	JJ
cord-022594-fx044gcd	784	13	immune	immune	JJ
cord-022594-fx044gcd	784	14	system	system	NN
cord-022594-fx044gcd	784	15	is	be	VBZ
cord-022594-fx044gcd	784	16	difficult	difficult	JJ
cord-022594-fx044gcd	784	17	if	if	IN
cord-022594-fx044gcd	784	18	not	not	RB
cord-022594-fx044gcd	784	19	impossible	impossible	JJ
cord-022594-fx044gcd	784	20	to	to	TO
cord-022594-fx044gcd	784	21	predict	predict	VB
cord-022594-fx044gcd	784	22	.	.	.
cord-022594-fx044gcd	785	1	Furthermore	furthermore	RB
cord-022594-fx044gcd	785	2	,	,	,
cord-022594-fx044gcd	785	3	our	-PRON-	PRP$
cord-022594-fx044gcd	785	4	inability	inability	NN
cord-022594-fx044gcd	785	5	to	to	TO
cord-022594-fx044gcd	785	6	treat	treat	VB
cord-022594-fx044gcd	785	7	MS	MS	NNP
cord-022594-fx044gcd	785	8	more	more	RBR
cord-022594-fx044gcd	785	9	effectively	effectively	RB
cord-022594-fx044gcd	785	10	does	do	VBZ
cord-022594-fx044gcd	785	11	not	not	RB
cord-022594-fx044gcd	785	12	stem	stem	VB
cord-022594-fx044gcd	785	13	from	from	IN
cord-022594-fx044gcd	785	14	the	the	DT
cord-022594-fx044gcd	785	15	fact	fact	NN
cord-022594-fx044gcd	785	16	that	that	IN
cord-022594-fx044gcd	785	17	we	-PRON-	PRP
cord-022594-fx044gcd	785	18	can	can	MD
cord-022594-fx044gcd	785	19	not	not	RB
cord-022594-fx044gcd	785	20	provide	provide	VB
cord-022594-fx044gcd	785	21	powerful	powerful	JJ
cord-022594-fx044gcd	785	22	immunosuppression	immunosuppression	NN
cord-022594-fx044gcd	785	23	,	,	,
cord-022594-fx044gcd	785	24	as	as	IN
cord-022594-fx044gcd	785	25	evidenced	evidence	VBN
cord-022594-fx044gcd	785	26	by	by	IN
cord-022594-fx044gcd	785	27	the	the	DT
cord-022594-fx044gcd	785	28	autologous	autologous	JJ
cord-022594-fx044gcd	785	29	bone	bone	NN
cord-022594-fx044gcd	785	30	marrow	marrow	NN
cord-022594-fx044gcd	785	31	transplantation	transplantation	NN
cord-022594-fx044gcd	785	32	studies	study	NNS
cord-022594-fx044gcd	785	33	.	.	.
cord-022594-fx044gcd	786	1	MS	MS	NNP
cord-022594-fx044gcd	786	2	is	be	VBZ
cord-022594-fx044gcd	786	3	a	a	DT
cord-022594-fx044gcd	786	4	complex	complex	JJ
cord-022594-fx044gcd	786	5	disease	disease	NN
cord-022594-fx044gcd	786	6	with	with	IN
cord-022594-fx044gcd	786	7	a	a	DT
cord-022594-fx044gcd	786	8	prominent	prominent	JJ
cord-022594-fx044gcd	786	9	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	786	10	component	component	NN
cord-022594-fx044gcd	786	11	;	;	:
cord-022594-fx044gcd	786	12	however	however	RB
cord-022594-fx044gcd	786	13	,	,	,
cord-022594-fx044gcd	786	14	increasing	increase	VBG
cord-022594-fx044gcd	786	15	evidence	evidence	NN
cord-022594-fx044gcd	786	16	suggests	suggest	VBZ
cord-022594-fx044gcd	786	17	that	that	IN
cord-022594-fx044gcd	786	18	the	the	DT
cord-022594-fx044gcd	786	19	neurodegenerative	neurodegenerative	JJ
cord-022594-fx044gcd	786	20	component	component	NN
cord-022594-fx044gcd	786	21	of	of	IN
cord-022594-fx044gcd	786	22	this	this	DT
cord-022594-fx044gcd	786	23	illness	illness	NN
cord-022594-fx044gcd	786	24	may	may	MD
cord-022594-fx044gcd	786	25	be	be	VB
cord-022594-fx044gcd	786	26	independent	independent	JJ
cord-022594-fx044gcd	786	27	of	of	IN
cord-022594-fx044gcd	786	28	the	the	DT
cord-022594-fx044gcd	786	29	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	786	30	component	component	NN
cord-022594-fx044gcd	786	31	,	,	,
cord-022594-fx044gcd	786	32	and	and	CC
cord-022594-fx044gcd	786	33	is	be	VBZ
cord-022594-fx044gcd	786	34	just	just	RB
cord-022594-fx044gcd	786	35	as	as	RB
cord-022594-fx044gcd	786	36	important	important	JJ
cord-022594-fx044gcd	786	37	,	,	,
cord-022594-fx044gcd	786	38	if	if	IN
cord-022594-fx044gcd	786	39	not	not	RB
cord-022594-fx044gcd	786	40	more	more	RBR
cord-022594-fx044gcd	786	41	important	important	JJ
cord-022594-fx044gcd	786	42	,	,	,
cord-022594-fx044gcd	786	43	from	from	IN
cord-022594-fx044gcd	786	44	the	the	DT
cord-022594-fx044gcd	786	45	standpoint	standpoint	NN
cord-022594-fx044gcd	786	46	of	of	IN
cord-022594-fx044gcd	786	47	long	long	JJ
cord-022594-fx044gcd	786	48	-	-	HYPH
cord-022594-fx044gcd	786	49	term	term	NN
cord-022594-fx044gcd	786	50	disability	disability	NN
cord-022594-fx044gcd	786	51	.	.	.
cord-022594-fx044gcd	787	1	Third	third	RB
cord-022594-fx044gcd	787	2	,	,	,
cord-022594-fx044gcd	787	3	in	in	IN
cord-022594-fx044gcd	787	4	chronic	chronic	JJ
cord-022594-fx044gcd	787	5	diseases	disease	NNS
cord-022594-fx044gcd	787	6	such	such	JJ
cord-022594-fx044gcd	787	7	as	as	IN
cord-022594-fx044gcd	787	8	MS	MS	NNP
cord-022594-fx044gcd	787	9	,	,	,
cord-022594-fx044gcd	787	10	a	a	DT
cord-022594-fx044gcd	787	11	short	short	JJ
cord-022594-fx044gcd	787	12	1-year	1-year	CD
cord-022594-fx044gcd	787	13	trial	trial	NN
cord-022594-fx044gcd	787	14	,	,	,
cord-022594-fx044gcd	787	15	no	no	RB
cord-022594-fx044gcd	787	16	matter	matter	RB
cord-022594-fx044gcd	787	17	how	how	WRB
cord-022594-fx044gcd	787	18	convincing	convince	VBG
cord-022594-fx044gcd	787	19	the	the	DT
cord-022594-fx044gcd	787	20	outcome	outcome	NN
cord-022594-fx044gcd	787	21	may	may	MD
cord-022594-fx044gcd	787	22	be	be	VB
cord-022594-fx044gcd	787	23	,	,	,
cord-022594-fx044gcd	787	24	should	should	MD
cord-022594-fx044gcd	787	25	not	not	RB
cord-022594-fx044gcd	787	26	be	be	VB
cord-022594-fx044gcd	787	27	considered	consider	VBN
cord-022594-fx044gcd	787	28	sufficient	sufficient	JJ
cord-022594-fx044gcd	787	29	to	to	TO
cord-022594-fx044gcd	787	30	approve	approve	VB
cord-022594-fx044gcd	787	31	a	a	DT
cord-022594-fx044gcd	787	32	medication	medication	NN
cord-022594-fx044gcd	787	33	,	,	,
cord-022594-fx044gcd	787	34	which	which	WDT
cord-022594-fx044gcd	787	35	will	will	MD
cord-022594-fx044gcd	787	36	then	then	RB
cord-022594-fx044gcd	787	37	be	be	VB
cord-022594-fx044gcd	787	38	used	use	VBN
cord-022594-fx044gcd	787	39	in	in	IN
cord-022594-fx044gcd	787	40	tens	ten	NNS
cord-022594-fx044gcd	787	41	of	of	IN
cord-022594-fx044gcd	787	42	thousands	thousand	NNS
cord-022594-fx044gcd	787	43	of	of	IN
cord-022594-fx044gcd	787	44	patients	patient	NNS
cord-022594-fx044gcd	787	45	on	on	IN
cord-022594-fx044gcd	787	46	a	a	DT
cord-022594-fx044gcd	787	47	"	"	``
cord-022594-fx044gcd	787	48	lifelong	lifelong	JJ
cord-022594-fx044gcd	787	49	"	"	''
cord-022594-fx044gcd	787	50	basis	basis	NN
cord-022594-fx044gcd	787	51	.	.	.
cord-022594-fx044gcd	788	1	There	there	EX
cord-022594-fx044gcd	788	2	clearly	clearly	RB
cord-022594-fx044gcd	788	3	is	be	VBZ
cord-022594-fx044gcd	788	4	a	a	DT
cord-022594-fx044gcd	788	5	need	need	NN
cord-022594-fx044gcd	788	6	for	for	IN
cord-022594-fx044gcd	788	7	new	new	JJ
cord-022594-fx044gcd	788	8	and	and	CC
cord-022594-fx044gcd	788	9	more	more	RBR
cord-022594-fx044gcd	788	10	effective	effective	JJ
cord-022594-fx044gcd	788	11	medications	medication	NNS
cord-022594-fx044gcd	788	12	for	for	IN
cord-022594-fx044gcd	788	13	treating	treat	VBG
cord-022594-fx044gcd	788	14	MS	MS	NNP
cord-022594-fx044gcd	788	15	;	;	:
cord-022594-fx044gcd	788	16	however	however	RB
cord-022594-fx044gcd	788	17	,	,	,
cord-022594-fx044gcd	788	18	clinical	clinical	JJ
cord-022594-fx044gcd	788	19	trials	trial	NNS
cord-022594-fx044gcd	788	20	in	in	IN
cord-022594-fx044gcd	788	21	chronic	chronic	JJ
cord-022594-fx044gcd	788	22	conditions	condition	NNS
cord-022594-fx044gcd	788	23	are	be	VBP
cord-022594-fx044gcd	788	24	very	very	RB
cord-022594-fx044gcd	788	25	difficult	difficult	JJ
cord-022594-fx044gcd	788	26	to	to	TO
cord-022594-fx044gcd	788	27	sustain	sustain	VB
cord-022594-fx044gcd	788	28	.	.	.
cord-022594-fx044gcd	789	1	To	to	TO
cord-022594-fx044gcd	789	2	overcome	overcome	VB
cord-022594-fx044gcd	789	3	this	this	DT
cord-022594-fx044gcd	789	4	,	,	,
cord-022594-fx044gcd	789	5	many	many	JJ
cord-022594-fx044gcd	789	6	MS	MS	NNP
cord-022594-fx044gcd	789	7	trials	trial	NNS
cord-022594-fx044gcd	789	8	use	use	VBP
cord-022594-fx044gcd	789	9	primary	primary	JJ
cord-022594-fx044gcd	789	10	MRI	MRI	NNP
cord-022594-fx044gcd	789	11	outcome	outcome	NN
cord-022594-fx044gcd	789	12	measures	measure	NNS
cord-022594-fx044gcd	789	13	,	,	,
cord-022594-fx044gcd	789	14	since	since	IN
cord-022594-fx044gcd	789	15	inflammation	inflammation	NN
cord-022594-fx044gcd	789	16	and	and	CC
cord-022594-fx044gcd	789	17	new	new	JJ
cord-022594-fx044gcd	789	18	lesion	lesion	NN
cord-022594-fx044gcd	789	19	formation	formation	NN
cord-022594-fx044gcd	789	20	-	-	HYPH
cord-022594-fx044gcd	789	21	related	relate	VBN
cord-022594-fx044gcd	789	22	MRI	MRI	NNP
cord-022594-fx044gcd	789	23	markers	marker	NNS
cord-022594-fx044gcd	789	24	respond	respond	VBP
cord-022594-fx044gcd	789	25	more	more	RBR
cord-022594-fx044gcd	789	26	immediately	immediately	RB
cord-022594-fx044gcd	789	27	to	to	IN
cord-022594-fx044gcd	789	28	treatment	treatment	NN
cord-022594-fx044gcd	789	29	;	;	:
cord-022594-fx044gcd	789	30	however	however	RB
cord-022594-fx044gcd	789	31	,	,	,
cord-022594-fx044gcd	789	32	these	these	DT
cord-022594-fx044gcd	789	33	markers	marker	NNS
cord-022594-fx044gcd	789	34	do	do	VBP
cord-022594-fx044gcd	789	35	not	not	RB
cord-022594-fx044gcd	789	36	correlate	correlate	VB
cord-022594-fx044gcd	789	37	well	well	RB
cord-022594-fx044gcd	789	38	with	with	IN
cord-022594-fx044gcd	789	39	long	long	JJ
cord-022594-fx044gcd	789	40	term	term	NN
cord-022594-fx044gcd	789	41	disability	disability	NN
cord-022594-fx044gcd	789	42	,	,	,
cord-022594-fx044gcd	789	43	as	as	IN
cord-022594-fx044gcd	789	44	discussed	discuss	VBN
cord-022594-fx044gcd	789	45	earlier	early	RBR
cord-022594-fx044gcd	789	46	.	.	.
cord-022594-fx044gcd	790	1	Summary	Summary	NNP
cord-022594-fx044gcd	790	2	of	of	IN
cord-022594-fx044gcd	790	3	Recommendations	Recommendations	NNPS
cord-022594-fx044gcd	790	4	for	for	IN
cord-022594-fx044gcd	790	5	the	the	DT
cord-022594-fx044gcd	790	6	Treatment	Treatment	NNP
cord-022594-fx044gcd	790	7	of	of	IN
cord-022594-fx044gcd	790	8	RRMS	RRMS	NNP
cord-022594-fx044gcd	790	9	Patients	Patients	NNPS
cord-022594-fx044gcd	790	10	.	.	.
cord-022594-fx044gcd	791	1	When	when	WRB
cord-022594-fx044gcd	791	2	making	make	VBG
cord-022594-fx044gcd	791	3	decisions	decision	NNS
cord-022594-fx044gcd	791	4	about	about	IN
cord-022594-fx044gcd	791	5	starting	start	VBG
cord-022594-fx044gcd	791	6	an	an	DT
cord-022594-fx044gcd	791	7	MS	MS	NNP
cord-022594-fx044gcd	791	8	patients	patient	NNS
cord-022594-fx044gcd	791	9	on	on	IN
cord-022594-fx044gcd	791	10	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	791	11	,	,	,
cord-022594-fx044gcd	791	12	several	several	JJ
cord-022594-fx044gcd	791	13	factors	factor	NNS
cord-022594-fx044gcd	791	14	must	must	MD
cord-022594-fx044gcd	791	15	be	be	VB
cord-022594-fx044gcd	791	16	considered	consider	VBN
cord-022594-fx044gcd	791	17	.	.	.
cord-022594-fx044gcd	792	1	One	one	PRP
cord-022594-fx044gcd	792	2	must	must	MD
cord-022594-fx044gcd	792	3	realize	realize	VB
cord-022594-fx044gcd	792	4	that	that	IN
cord-022594-fx044gcd	792	5	even	even	RB
cord-022594-fx044gcd	792	6	though	though	IN
cord-022594-fx044gcd	792	7	there	there	EX
cord-022594-fx044gcd	792	8	are	be	VBP
cord-022594-fx044gcd	792	9	medications	medication	NNS
cord-022594-fx044gcd	792	10	available	available	JJ
cord-022594-fx044gcd	792	11	for	for	IN
cord-022594-fx044gcd	792	12	relapsing	relapse	VBG
cord-022594-fx044gcd	792	13	forms	form	NNS
cord-022594-fx044gcd	792	14	of	of	IN
cord-022594-fx044gcd	792	15	MS	MS	NNP
cord-022594-fx044gcd	792	16	,	,	,
cord-022594-fx044gcd	792	17	all	all	PDT
cord-022594-fx044gcd	792	18	the	the	DT
cord-022594-fx044gcd	792	19	currently	currently	RB
cord-022594-fx044gcd	792	20	available	available	JJ
cord-022594-fx044gcd	792	21	therapies	therapy	NNS
cord-022594-fx044gcd	792	22	are	be	VBP
cord-022594-fx044gcd	792	23	only	only	RB
cord-022594-fx044gcd	792	24	partially	partially	RB
cord-022594-fx044gcd	792	25	effective	effective	JJ
cord-022594-fx044gcd	792	26	,	,	,
cord-022594-fx044gcd	792	27	the	the	DT
cord-022594-fx044gcd	792	28	most	most	RBS
cord-022594-fx044gcd	792	29	reliable	reliable	JJ
cord-022594-fx044gcd	792	30	data	data	NN
cord-022594-fx044gcd	792	31	is	be	VBZ
cord-022594-fx044gcd	792	32	about	about	IN
cord-022594-fx044gcd	792	33	short	short	JJ
cord-022594-fx044gcd	792	34	-	-	HYPH
cord-022594-fx044gcd	792	35	term	term	NN
cord-022594-fx044gcd	792	36	relapse	relapse	NN
cord-022594-fx044gcd	792	37	rate	rate	NN
cord-022594-fx044gcd	792	38	reduction	reduction	NN
cord-022594-fx044gcd	792	39	,	,	,
cord-022594-fx044gcd	792	40	and	and	CC
cord-022594-fx044gcd	792	41	a	a	DT
cord-022594-fx044gcd	792	42	relapse	relapse	NN
cord-022594-fx044gcd	792	43	rate	rate	NN
cord-022594-fx044gcd	792	44	reduction	reduction	NN
cord-022594-fx044gcd	792	45	does	do	VBZ
cord-022594-fx044gcd	792	46	not	not	RB
cord-022594-fx044gcd	792	47	necessarily	necessarily	RB
cord-022594-fx044gcd	792	48	translate	translate	VB
cord-022594-fx044gcd	792	49	into	into	IN
cord-022594-fx044gcd	792	50	reduction	reduction	NN
cord-022594-fx044gcd	792	51	of	of	IN
cord-022594-fx044gcd	792	52	future	future	JJ
cord-022594-fx044gcd	792	53	disabilities	disability	NNS
cord-022594-fx044gcd	792	54	.	.	.
cord-022594-fx044gcd	793	1	Natural	natural	JJ
cord-022594-fx044gcd	793	2	history	history	NN
cord-022594-fx044gcd	793	3	data	datum	NNS
cord-022594-fx044gcd	793	4	clearly	clearly	RB
cord-022594-fx044gcd	793	5	suggest	suggest	VBP
cord-022594-fx044gcd	793	6	that	that	IN
cord-022594-fx044gcd	793	7	a	a	DT
cord-022594-fx044gcd	793	8	subset	subset	NN
cord-022594-fx044gcd	793	9	of	of	IN
cord-022594-fx044gcd	793	10	MS	MS	NNP
cord-022594-fx044gcd	793	11	patients	patient	NNS
cord-022594-fx044gcd	793	12	will	will	MD
cord-022594-fx044gcd	793	13	do	do	VB
cord-022594-fx044gcd	793	14	very	very	RB
cord-022594-fx044gcd	793	15	well	well	RB
cord-022594-fx044gcd	793	16	without	without	IN
cord-022594-fx044gcd	793	17	treatment	treatment	NN
cord-022594-fx044gcd	793	18	(	(	-LRB-
cord-022594-fx044gcd	793	19	see	see	VB
cord-022594-fx044gcd	793	20	discussion	discussion	NN
cord-022594-fx044gcd	793	21	about	about	IN
cord-022594-fx044gcd	793	22	the	the	DT
cord-022594-fx044gcd	793	23	Olmsted	Olmsted	NNP
cord-022594-fx044gcd	793	24	County	County	NNP
cord-022594-fx044gcd	793	25	cohort	cohort	NN
cord-022594-fx044gcd	793	26	later	later	RB
cord-022594-fx044gcd	793	27	)	)	-RRB-
cord-022594-fx044gcd	793	28	;	;	:
cord-022594-fx044gcd	793	29	this	this	DT
cord-022594-fx044gcd	793	30	information	information	NN
cord-022594-fx044gcd	793	31	can	can	MD
cord-022594-fx044gcd	793	32	be	be	VB
cord-022594-fx044gcd	793	33	very	very	RB
cord-022594-fx044gcd	793	34	useful	useful	JJ
cord-022594-fx044gcd	793	35	when	when	WRB
cord-022594-fx044gcd	793	36	deciding	decide	VBG
cord-022594-fx044gcd	793	37	about	about	IN
cord-022594-fx044gcd	793	38	treatment	treatment	NN
cord-022594-fx044gcd	793	39	in	in	IN
cord-022594-fx044gcd	793	40	patients	patient	NNS
cord-022594-fx044gcd	793	41	with	with	IN
cord-022594-fx044gcd	793	42	a	a	DT
cord-022594-fx044gcd	793	43	5-or	5-or	CD
cord-022594-fx044gcd	793	44	10-year	10-year	CD
cord-022594-fx044gcd	793	45	disease	disease	NN
cord-022594-fx044gcd	793	46	history	history	NN
cord-022594-fx044gcd	793	47	and	and	CC
cord-022594-fx044gcd	793	48	minimal	minimal	JJ
cord-022594-fx044gcd	793	49	disability	disability	NN
cord-022594-fx044gcd	793	50	(	(	-LRB-
cord-022594-fx044gcd	793	51	EDSS	EDSS	NNP
cord-022594-fx044gcd	793	52	2.0	2.0	CD
cord-022594-fx044gcd	793	53	)	)	-RRB-
cord-022594-fx044gcd	793	54	.	.	.
cord-022594-fx044gcd	794	1	In	in	IN
cord-022594-fx044gcd	794	2	this	this	DT
cord-022594-fx044gcd	794	3	patient	patient	NN
cord-022594-fx044gcd	794	4	group	group	NN
cord-022594-fx044gcd	794	5	,	,	,
cord-022594-fx044gcd	794	6	a	a	DT
cord-022594-fx044gcd	794	7	careful	careful	JJ
cord-022594-fx044gcd	794	8	wait	wait	NN
cord-022594-fx044gcd	794	9	and	and	CC
cord-022594-fx044gcd	794	10	see	see	VB
cord-022594-fx044gcd	794	11	approach	approach	NN
cord-022594-fx044gcd	794	12	with	with	IN
cord-022594-fx044gcd	794	13	appropriate	appropriate	JJ
cord-022594-fx044gcd	794	14	monitoring	monitoring	NN
cord-022594-fx044gcd	794	15	is	be	VBZ
cord-022594-fx044gcd	794	16	acceptable	acceptable	JJ
cord-022594-fx044gcd	794	17	.	.	.
cord-022594-fx044gcd	795	1	Counseling	counseling	NN
cord-022594-fx044gcd	795	2	of	of	IN
cord-022594-fx044gcd	795	3	newly	newly	RB
cord-022594-fx044gcd	795	4	diagnosed	diagnose	VBN
cord-022594-fx044gcd	795	5	MS	MS	NNP
cord-022594-fx044gcd	795	6	patients	patient	NNS
cord-022594-fx044gcd	795	7	is	be	VBZ
cord-022594-fx044gcd	795	8	of	of	IN
cord-022594-fx044gcd	795	9	crucial	crucial	JJ
cord-022594-fx044gcd	795	10	importance	importance	NN
cord-022594-fx044gcd	795	11	,	,	,
cord-022594-fx044gcd	795	12	and	and	CC
cord-022594-fx044gcd	795	13	it	-PRON-	PRP
cord-022594-fx044gcd	795	14	should	should	MD
cord-022594-fx044gcd	795	15	usually	usually	RB
cord-022594-fx044gcd	795	16	include	include	VB
cord-022594-fx044gcd	795	17	family	family	NN
cord-022594-fx044gcd	795	18	members	member	NNS
cord-022594-fx044gcd	795	19	.	.	.
cord-022594-fx044gcd	796	1	Most	Most	JJS
cord-022594-fx044gcd	796	2	patients	patient	NNS
cord-022594-fx044gcd	796	3	have	have	VBP
cord-022594-fx044gcd	796	4	easy	easy	JJ
cord-022594-fx044gcd	796	5	access	access	NN
cord-022594-fx044gcd	796	6	to	to	IN
cord-022594-fx044gcd	796	7	an	an	DT
cord-022594-fx044gcd	796	8	abundance	abundance	NN
cord-022594-fx044gcd	796	9	of	of	IN
cord-022594-fx044gcd	796	10	frequently	frequently	RB
cord-022594-fx044gcd	796	11	misleading	mislead	VBG
cord-022594-fx044gcd	796	12	information	information	NN
cord-022594-fx044gcd	796	13	on	on	IN
cord-022594-fx044gcd	796	14	the	the	DT
cord-022594-fx044gcd	796	15	Internet	internet	NN
cord-022594-fx044gcd	796	16	,	,	,
cord-022594-fx044gcd	796	17	or	or	CC
cord-022594-fx044gcd	796	18	from	from	IN
cord-022594-fx044gcd	796	19	relatives	relative	NNS
cord-022594-fx044gcd	796	20	and	and	CC
cord-022594-fx044gcd	796	21	friends	friend	NNS
cord-022594-fx044gcd	796	22	with	with	IN
cord-022594-fx044gcd	796	23	MS	MS	NNP
cord-022594-fx044gcd	796	24	.	.	.
cord-022594-fx044gcd	797	1	It	-PRON-	PRP
cord-022594-fx044gcd	797	2	is	be	VBZ
cord-022594-fx044gcd	797	3	important	important	JJ
cord-022594-fx044gcd	797	4	to	to	TO
cord-022594-fx044gcd	797	5	realize	realize	VB
cord-022594-fx044gcd	797	6	that	that	IN
cord-022594-fx044gcd	797	7	every	every	DT
cord-022594-fx044gcd	797	8	case	case	NN
cord-022594-fx044gcd	797	9	is	be	VBZ
cord-022594-fx044gcd	797	10	different	different	JJ
cord-022594-fx044gcd	797	11	;	;	:
cord-022594-fx044gcd	797	12	however	however	RB
cord-022594-fx044gcd	797	13	,	,	,
cord-022594-fx044gcd	797	14	through	through	IN
cord-022594-fx044gcd	797	15	the	the	DT
cord-022594-fx044gcd	797	16	rational	rational	JJ
cord-022594-fx044gcd	797	17	use	use	NN
cord-022594-fx044gcd	797	18	of	of	IN
cord-022594-fx044gcd	797	19	natural	natural	JJ
cord-022594-fx044gcd	797	20	history	history	NN
cord-022594-fx044gcd	797	21	data	datum	NNS
cord-022594-fx044gcd	797	22	,	,	,
cord-022594-fx044gcd	797	23	clinical	clinical	JJ
cord-022594-fx044gcd	797	24	and	and	CC
cord-022594-fx044gcd	797	25	MRI	MRI	NNP
cord-022594-fx044gcd	797	26	features	feature	NNS
cord-022594-fx044gcd	797	27	of	of	IN
cord-022594-fx044gcd	797	28	the	the	DT
cord-022594-fx044gcd	797	29	specific	specific	JJ
cord-022594-fx044gcd	797	30	case	case	NN
cord-022594-fx044gcd	797	31	,	,	,
cord-022594-fx044gcd	797	32	and	and	CC
cord-022594-fx044gcd	797	33	the	the	DT
cord-022594-fx044gcd	797	34	clear	clear	JJ
cord-022594-fx044gcd	797	35	understanding	understanding	NN
cord-022594-fx044gcd	797	36	of	of	IN
cord-022594-fx044gcd	797	37	the	the	DT
cord-022594-fx044gcd	797	38	available	available	JJ
cord-022594-fx044gcd	797	39	clinical	clinical	JJ
cord-022594-fx044gcd	797	40	trial	trial	NN
cord-022594-fx044gcd	797	41	data	datum	NNS
cord-022594-fx044gcd	797	42	,	,	,
cord-022594-fx044gcd	797	43	the	the	DT
cord-022594-fx044gcd	797	44	clinician	clinician	NN
cord-022594-fx044gcd	797	45	should	should	MD
cord-022594-fx044gcd	797	46	be	be	VB
cord-022594-fx044gcd	797	47	able	able	JJ
cord-022594-fx044gcd	797	48	to	to	TO
cord-022594-fx044gcd	797	49	provide	provide	VB
cord-022594-fx044gcd	797	50	customized	customize	VBN
cord-022594-fx044gcd	797	51	and	and	CC
cord-022594-fx044gcd	797	52	relevant	relevant	JJ
cord-022594-fx044gcd	797	53	advice	advice	NN
cord-022594-fx044gcd	797	54	to	to	IN
cord-022594-fx044gcd	797	55	patients	patient	NNS
cord-022594-fx044gcd	797	56	and	and	CC
cord-022594-fx044gcd	797	57	families	family	NNS
cord-022594-fx044gcd	797	58	.	.	.
cord-022594-fx044gcd	798	1	Considering	consider	VBG
cord-022594-fx044gcd	798	2	that	that	IN
cord-022594-fx044gcd	798	3	the	the	DT
cord-022594-fx044gcd	798	4	treatments	treatment	NNS
cord-022594-fx044gcd	798	5	are	be	VBP
cord-022594-fx044gcd	798	6	only	only	RB
cord-022594-fx044gcd	798	7	partially	partially	RB
cord-022594-fx044gcd	798	8	effective	effective	JJ
cord-022594-fx044gcd	798	9	,	,	,
cord-022594-fx044gcd	798	10	the	the	DT
cord-022594-fx044gcd	798	11	wishes	wish	NNS
cord-022594-fx044gcd	798	12	of	of	IN
cord-022594-fx044gcd	798	13	an	an	DT
cord-022594-fx044gcd	798	14	educated	educate	VBN
cord-022594-fx044gcd	798	15	patient	patient	NN
cord-022594-fx044gcd	798	16	constitute	constitute	VBP
cord-022594-fx044gcd	798	17	an	an	DT
cord-022594-fx044gcd	798	18	important	important	JJ
cord-022594-fx044gcd	798	19	part	part	NN
cord-022594-fx044gcd	798	20	in	in	IN
cord-022594-fx044gcd	798	21	the	the	DT
cord-022594-fx044gcd	798	22	decision	decision	NN
cord-022594-fx044gcd	798	23	-	-	HYPH
cord-022594-fx044gcd	798	24	making	make	VBG
cord-022594-fx044gcd	798	25	process	process	NN
cord-022594-fx044gcd	798	26	.	.	.
cord-022594-fx044gcd	799	1	Ultimately	ultimately	RB
cord-022594-fx044gcd	799	2	,	,	,
cord-022594-fx044gcd	799	3	the	the	DT
cord-022594-fx044gcd	799	4	treatment	treatment	NN
cord-022594-fx044gcd	799	5	decisions	decision	NNS
cord-022594-fx044gcd	799	6	should	should	MD
cord-022594-fx044gcd	799	7	remain	remain	VB
cord-022594-fx044gcd	799	8	individualized	individualized	JJ
cord-022594-fx044gcd	799	9	between	between	IN
cord-022594-fx044gcd	799	10	the	the	DT
cord-022594-fx044gcd	799	11	patients	patient	NNS
cord-022594-fx044gcd	799	12	and	and	CC
cord-022594-fx044gcd	799	13	their	-PRON-	PRP$
cord-022594-fx044gcd	799	14	treating	treat	VBG
cord-022594-fx044gcd	799	15	physicians	physician	NNS
cord-022594-fx044gcd	799	16	,	,	,
cord-022594-fx044gcd	799	17	and	and	CC
cord-022594-fx044gcd	799	18	the	the	DT
cord-022594-fx044gcd	799	19	physician	physician	NN
cord-022594-fx044gcd	799	20	's	's	POS
cord-022594-fx044gcd	799	21	role	role	NN
cord-022594-fx044gcd	799	22	as	as	IN
cord-022594-fx044gcd	799	23	an	an	DT
cord-022594-fx044gcd	799	24	information	information	NN
cord-022594-fx044gcd	799	25	clearinghouse	clearinghouse	NN
cord-022594-fx044gcd	799	26	and	and	CC
cord-022594-fx044gcd	799	27	educator	educator	NN
cord-022594-fx044gcd	799	28	can	can	MD
cord-022594-fx044gcd	799	29	not	not	RB
cord-022594-fx044gcd	799	30	be	be	VB
cord-022594-fx044gcd	799	31	overemphasized	overemphasize	VBN
cord-022594-fx044gcd	799	32	in	in	IN
cord-022594-fx044gcd	799	33	this	this	DT
cord-022594-fx044gcd	799	34	process	process	NN
cord-022594-fx044gcd	799	35	.	.	.
cord-022594-fx044gcd	800	1	The	the	DT
cord-022594-fx044gcd	800	2	three	three	CD
cord-022594-fx044gcd	800	3	interferon	interferon	NN
cord-022594-fx044gcd	800	4	products	product	NNS
cord-022594-fx044gcd	800	5	and	and	CC
cord-022594-fx044gcd	800	6	GA	GA	NNP
cord-022594-fx044gcd	800	7	represent	represent	VBP
cord-022594-fx044gcd	800	8	the	the	DT
cord-022594-fx044gcd	800	9	most	most	RBS
cord-022594-fx044gcd	800	10	commonly	commonly	RB
cord-022594-fx044gcd	800	11	used	use	VBN
cord-022594-fx044gcd	800	12	MS	MS	NNP
cord-022594-fx044gcd	800	13	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	800	14	in	in	IN
cord-022594-fx044gcd	800	15	the	the	DT
cord-022594-fx044gcd	800	16	United	United	NNP
cord-022594-fx044gcd	800	17	States	States	NNP
cord-022594-fx044gcd	800	18	;	;	:
cord-022594-fx044gcd	800	19	therefore	therefore	RB
cord-022594-fx044gcd	800	20	,	,	,
cord-022594-fx044gcd	800	21	it	-PRON-	PRP
cord-022594-fx044gcd	800	22	is	be	VBZ
cord-022594-fx044gcd	800	23	important	important	JJ
cord-022594-fx044gcd	800	24	to	to	TO
cord-022594-fx044gcd	800	25	draw	draw	VB
cord-022594-fx044gcd	800	26	some	some	DT
cord-022594-fx044gcd	800	27	practical	practical	JJ
cord-022594-fx044gcd	800	28	conclusions	conclusion	NNS
cord-022594-fx044gcd	800	29	about	about	IN
cord-022594-fx044gcd	800	30	these	these	DT
cord-022594-fx044gcd	800	31	agents	agent	NNS
cord-022594-fx044gcd	800	32	.	.	.
cord-022594-fx044gcd	801	1	By	by	IN
cord-022594-fx044gcd	801	2	now	now	RB
cord-022594-fx044gcd	801	3	,	,	,
cord-022594-fx044gcd	801	4	several	several	JJ
cord-022594-fx044gcd	801	5	class	class	NN
cord-022594-fx044gcd	801	6	I	-PRON-	PRP
cord-022594-fx044gcd	801	7	studies	study	NNS
cord-022594-fx044gcd	801	8	demonstrate	demonstrate	VBP
cord-022594-fx044gcd	801	9	that	that	IN
cord-022594-fx044gcd	801	10	these	these	DT
cord-022594-fx044gcd	801	11	agents	agent	NNS
cord-022594-fx044gcd	801	12	are	be	VBP
cord-022594-fx044gcd	801	13	effective	effective	JJ
cord-022594-fx044gcd	801	14	in	in	IN
cord-022594-fx044gcd	801	15	reducing	reduce	VBG
cord-022594-fx044gcd	801	16	the	the	DT
cord-022594-fx044gcd	801	17	relapse	relapse	NN
cord-022594-fx044gcd	801	18	rate	rate	NN
cord-022594-fx044gcd	801	19	in	in	IN
cord-022594-fx044gcd	801	20	RRMS	RRMS	NNP
cord-022594-fx044gcd	801	21	over	over	IN
cord-022594-fx044gcd	801	22	a	a	DT
cord-022594-fx044gcd	801	23	2-to	2-to	CD
cord-022594-fx044gcd	801	24	3-year	3-year	CD
cord-022594-fx044gcd	801	25	period	period	NN
cord-022594-fx044gcd	801	26	;	;	:
cord-022594-fx044gcd	801	27	the	the	DT
cord-022594-fx044gcd	801	28	reduction	reduction	NN
cord-022594-fx044gcd	801	29	is	be	VBZ
cord-022594-fx044gcd	801	30	roughly	roughly	RB
cord-022594-fx044gcd	801	31	30	30	CD
cord-022594-fx044gcd	801	32	%	%	NN
cord-022594-fx044gcd	801	33	with	with	IN
cord-022594-fx044gcd	801	34	the	the	DT
cord-022594-fx044gcd	801	35	high	high	JJ
cord-022594-fx044gcd	801	36	-	-	HYPH
cord-022594-fx044gcd	801	37	dose	dose	NN
cord-022594-fx044gcd	801	38	interferons	interferon	NNS
cord-022594-fx044gcd	801	39	and	and	CC
cord-022594-fx044gcd	801	40	GA	GA	NNP
cord-022594-fx044gcd	801	41	.	.	.
cord-022594-fx044gcd	802	1	The	the	DT
cord-022594-fx044gcd	802	2	above	above	RB
cord-022594-fx044gcd	802	3	-	-	HYPH
cord-022594-fx044gcd	802	4	mentioned	mention	VBN
cord-022594-fx044gcd	802	5	NNT	NNT	NNP
cord-022594-fx044gcd	802	6	data	datum	NNS
cord-022594-fx044gcd	802	7	are	be	VBP
cord-022594-fx044gcd	802	8	also	also	RB
cord-022594-fx044gcd	802	9	very	very	RB
cord-022594-fx044gcd	802	10	useful	useful	JJ
cord-022594-fx044gcd	802	11	for	for	IN
cord-022594-fx044gcd	802	12	the	the	DT
cord-022594-fx044gcd	802	13	clinician	clinician	NN
cord-022594-fx044gcd	802	14	and	and	CC
cord-022594-fx044gcd	802	15	the	the	DT
cord-022594-fx044gcd	802	16	well	well	RB
cord-022594-fx044gcd	802	17	-	-	HYPH
cord-022594-fx044gcd	802	18	informed	inform	VBN
cord-022594-fx044gcd	802	19	patient	patient	NN
cord-022594-fx044gcd	802	20	when	when	WRB
cord-022594-fx044gcd	802	21	making	make	VBG
cord-022594-fx044gcd	802	22	treatment	treatment	NN
cord-022594-fx044gcd	802	23	decisions	decision	NNS
cord-022594-fx044gcd	802	24	.	.	.
cord-022594-fx044gcd	803	1	There	there	EX
cord-022594-fx044gcd	803	2	is	be	VBZ
cord-022594-fx044gcd	803	3	evidence	evidence	NN
cord-022594-fx044gcd	803	4	for	for	IN
cord-022594-fx044gcd	803	5	a	a	DT
cord-022594-fx044gcd	803	6	dose	dose	JJ
cord-022594-fx044gcd	803	7	-	-	HYPH
cord-022594-fx044gcd	803	8	response	response	NN
cord-022594-fx044gcd	803	9	relationship	relationship	NN
cord-022594-fx044gcd	803	10	among	among	IN
cord-022594-fx044gcd	803	11	the	the	DT
cord-022594-fx044gcd	803	12	interferon	interferon	NN
cord-022594-fx044gcd	803	13	products	product	NNS
cord-022594-fx044gcd	803	14	,	,	,
cord-022594-fx044gcd	803	15	mostly	mostly	RB
cord-022594-fx044gcd	803	16	from	from	IN
cord-022594-fx044gcd	803	17	the	the	DT
cord-022594-fx044gcd	803	18	EVIDENCE	EVIDENCE	NNP
cord-022594-fx044gcd	803	19	and	and	CC
cord-022594-fx044gcd	803	20	INCOMIN	INCOMIN	NNP
cord-022594-fx044gcd	803	21	studies	study	NNS
cord-022594-fx044gcd	803	22	.	.	.
cord-022594-fx044gcd	804	1	The	the	DT
cord-022594-fx044gcd	804	2	double	double	JJ
cord-022594-fx044gcd	804	3	dose	dose	NN
cord-022594-fx044gcd	804	4	IM	IM	NNP
cord-022594-fx044gcd	804	5	interferon	interferon	NN
cord-022594-fx044gcd	804	6	-	-	HYPH
cord-022594-fx044gcd	804	7	b	b	NN
cord-022594-fx044gcd	804	8	1a	1a	CD
cord-022594-fx044gcd	804	9	study	study	NN
cord-022594-fx044gcd	804	10	did	do	VBD
cord-022594-fx044gcd	804	11	not	not	RB
cord-022594-fx044gcd	804	12	show	show	VB
cord-022594-fx044gcd	804	13	a	a	DT
cord-022594-fx044gcd	804	14	dose	dose	JJ
cord-022594-fx044gcd	804	15	-	-	HYPH
cord-022594-fx044gcd	804	16	response	response	NN
cord-022594-fx044gcd	804	17	relationship	relationship	NN
cord-022594-fx044gcd	804	18	;	;	:
cord-022594-fx044gcd	804	19	this	this	DT
cord-022594-fx044gcd	804	20	may	may	MD
cord-022594-fx044gcd	804	21	be	be	VB
cord-022594-fx044gcd	804	22	related	relate	VBN
cord-022594-fx044gcd	804	23	to	to	IN
cord-022594-fx044gcd	804	24	the	the	DT
cord-022594-fx044gcd	804	25	fact	fact	NN
cord-022594-fx044gcd	804	26	that	that	IN
cord-022594-fx044gcd	804	27	the	the	DT
cord-022594-fx044gcd	804	28	increased	increase	VBN
cord-022594-fx044gcd	804	29	dose	dose	NN
cord-022594-fx044gcd	804	30	was	be	VBD
cord-022594-fx044gcd	804	31	given	give	VBN
cord-022594-fx044gcd	804	32	with	with	IN
cord-022594-fx044gcd	804	33	the	the	DT
cord-022594-fx044gcd	804	34	same	same	JJ
cord-022594-fx044gcd	804	35	frequency	frequency	NN
cord-022594-fx044gcd	804	36	as	as	IN
cord-022594-fx044gcd	804	37	the	the	DT
cord-022594-fx044gcd	804	38	standard	standard	JJ
cord-022594-fx044gcd	804	39	dose	dose	NN
cord-022594-fx044gcd	804	40	.	.	.
cord-022594-fx044gcd	805	1	The	the	DT
cord-022594-fx044gcd	805	2	injectable	injectable	JJ
cord-022594-fx044gcd	805	3	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	805	4	have	have	VBP
cord-022594-fx044gcd	805	5	incomplete	incomplete	JJ
cord-022594-fx044gcd	805	6	evidence	evidence	NN
cord-022594-fx044gcd	805	7	for	for	IN
cord-022594-fx044gcd	805	8	efficacy	efficacy	NN
cord-022594-fx044gcd	805	9	in	in	IN
cord-022594-fx044gcd	805	10	disability	disability	NN
cord-022594-fx044gcd	805	11	-	-	HYPH
cord-022594-fx044gcd	805	12	based	base	VBN
cord-022594-fx044gcd	805	13	outcome	outcome	NN
cord-022594-fx044gcd	805	14	measures	measure	NNS
cord-022594-fx044gcd	805	15	.	.	.
cord-022594-fx044gcd	806	1	Many	many	JJ
cord-022594-fx044gcd	806	2	of	of	IN
cord-022594-fx044gcd	806	3	the	the	DT
cord-022594-fx044gcd	806	4	long	long	JJ
cord-022594-fx044gcd	806	5	-	-	HYPH
cord-022594-fx044gcd	806	6	term	term	NN
cord-022594-fx044gcd	806	7	extension	extension	NN
cord-022594-fx044gcd	806	8	studies	study	NNS
cord-022594-fx044gcd	806	9	suffer	suffer	VBP
cord-022594-fx044gcd	806	10	from	from	IN
cord-022594-fx044gcd	806	11	several	several	JJ
cord-022594-fx044gcd	806	12	drawbacks	drawback	NNS
cord-022594-fx044gcd	806	13	,	,	,
cord-022594-fx044gcd	806	14	including	include	VBG
cord-022594-fx044gcd	806	15	open	open	JJ
cord-022594-fx044gcd	806	16	label	label	NN
cord-022594-fx044gcd	806	17	unblinded	unblinded	JJ
cord-022594-fx044gcd	806	18	design	design	NN
cord-022594-fx044gcd	806	19	,	,	,
cord-022594-fx044gcd	806	20	significant	significant	JJ
cord-022594-fx044gcd	806	21	dropout	dropout	NN
cord-022594-fx044gcd	806	22	rate	rate	NN
cord-022594-fx044gcd	806	23	,	,	,
cord-022594-fx044gcd	806	24	and	and	CC
cord-022594-fx044gcd	806	25	lack	lack	NN
cord-022594-fx044gcd	806	26	of	of	IN
cord-022594-fx044gcd	806	27	control	control	NN
cord-022594-fx044gcd	806	28	subjects	subject	NNS
cord-022594-fx044gcd	806	29	;	;	:
cord-022594-fx044gcd	806	30	this	this	DT
cord-022594-fx044gcd	806	31	is	be	VBZ
cord-022594-fx044gcd	806	32	especially	especially	RB
cord-022594-fx044gcd	806	33	true	true	JJ
cord-022594-fx044gcd	806	34	for	for	IN
cord-022594-fx044gcd	806	35	the	the	DT
cord-022594-fx044gcd	806	36	GA	GA	NNP
cord-022594-fx044gcd	806	37	extension	extension	NN
cord-022594-fx044gcd	806	38	data	datum	NNS
cord-022594-fx044gcd	806	39	.	.	.
cord-022594-fx044gcd	807	1	The	the	DT
cord-022594-fx044gcd	807	2	currently	currently	RB
cord-022594-fx044gcd	807	3	available	available	JJ
cord-022594-fx044gcd	807	4	few	few	JJ
cord-022594-fx044gcd	807	5	head	head	NN
cord-022594-fx044gcd	807	6	-	-	HYPH
cord-022594-fx044gcd	807	7	to	to	IN
cord-022594-fx044gcd	807	8	-	-	HYPH
cord-022594-fx044gcd	807	9	head	head	NN
cord-022594-fx044gcd	807	10	comparison	comparison	NN
cord-022594-fx044gcd	807	11	studies	study	NNS
cord-022594-fx044gcd	807	12	are	be	VBP
cord-022594-fx044gcd	807	13	also	also	RB
cord-022594-fx044gcd	807	14	hampered	hamper	VBN
cord-022594-fx044gcd	807	15	with	with	IN
cord-022594-fx044gcd	807	16	methodological	methodological	JJ
cord-022594-fx044gcd	807	17	issues	issue	NNS
cord-022594-fx044gcd	807	18	;	;	,
cord-022594-fx044gcd	807	19	new	new	JJ
cord-022594-fx044gcd	807	20	comparative	comparative	JJ
cord-022594-fx044gcd	807	21	studies	study	NNS
cord-022594-fx044gcd	807	22	are	be	VBP
cord-022594-fx044gcd	807	23	under	under	IN
cord-022594-fx044gcd	807	24	way	way	NN
cord-022594-fx044gcd	807	25	.	.	.
cord-022594-fx044gcd	808	1	Overall	overall	RB
cord-022594-fx044gcd	808	2	,	,	,
cord-022594-fx044gcd	808	3	these	these	DT
cord-022594-fx044gcd	808	4	agents	agent	NNS
cord-022594-fx044gcd	808	5	remain	remain	VBP
cord-022594-fx044gcd	808	6	partially	partially	RB
cord-022594-fx044gcd	808	7	effective	effective	JJ
cord-022594-fx044gcd	808	8	in	in	IN
cord-022594-fx044gcd	808	9	relapsing	relapse	VBG
cord-022594-fx044gcd	808	10	forms	form	NNS
cord-022594-fx044gcd	808	11	of	of	IN
cord-022594-fx044gcd	808	12	MS	MS	NNP
cord-022594-fx044gcd	808	13	;	;	:
cord-022594-fx044gcd	808	14	their	-PRON-	PRP$
cord-022594-fx044gcd	808	15	long	long	JJ
cord-022594-fx044gcd	808	16	-	-	HYPH
cord-022594-fx044gcd	808	17	term	term	NN
cord-022594-fx044gcd	808	18	effects	effect	NNS
cord-022594-fx044gcd	808	19	on	on	IN
cord-022594-fx044gcd	808	20	reducing	reduce	VBG
cord-022594-fx044gcd	808	21	the	the	DT
cord-022594-fx044gcd	808	22	clinically	clinically	RB
cord-022594-fx044gcd	808	23	most	most	RBS
cord-022594-fx044gcd	808	24	important	important	JJ
cord-022594-fx044gcd	808	25	feature	feature	NN
cord-022594-fx044gcd	808	26	of	of	IN
cord-022594-fx044gcd	808	27	MS	MS	NNP
cord-022594-fx044gcd	808	28	-	-	HYPH
cord-022594-fx044gcd	808	29	disability	disability	NN
cord-022594-fx044gcd	808	30	-	-	:
cord-022594-fx044gcd	808	31	still	still	RB
cord-022594-fx044gcd	808	32	remains	remain	VBZ
cord-022594-fx044gcd	808	33	unclear	unclear	JJ
cord-022594-fx044gcd	808	34	.	.	.
cord-022594-fx044gcd	809	1	Altering	alter	VBG
cord-022594-fx044gcd	809	2	the	the	DT
cord-022594-fx044gcd	809	3	Course	Course	NNP
cord-022594-fx044gcd	809	4	of	of	IN
cord-022594-fx044gcd	809	5	Secondary	Secondary	NNP
cord-022594-fx044gcd	809	6	Progressive	Progressive	NNP
cord-022594-fx044gcd	809	7	MS	MS	NNP
cord-022594-fx044gcd	809	8	.	.	.
cord-022594-fx044gcd	810	1	Within	within	IN
cord-022594-fx044gcd	810	2	15	15	CD
cord-022594-fx044gcd	810	3	years	year	NNS
cord-022594-fx044gcd	810	4	of	of	IN
cord-022594-fx044gcd	810	5	onset	onset	NN
cord-022594-fx044gcd	810	6	,	,	,
cord-022594-fx044gcd	810	7	almost	almost	RB
cord-022594-fx044gcd	810	8	60	60	CD
cord-022594-fx044gcd	810	9	%	%	NN
cord-022594-fx044gcd	810	10	of	of	IN
cord-022594-fx044gcd	810	11	RRMS	RRMS	NNP
cord-022594-fx044gcd	810	12	patients	patient	NNS
cord-022594-fx044gcd	810	13	will	will	MD
cord-022594-fx044gcd	810	14	enter	enter	VB
cord-022594-fx044gcd	810	15	the	the	DT
cord-022594-fx044gcd	810	16	secondary	secondary	JJ
cord-022594-fx044gcd	810	17	progressive	progressive	JJ
cord-022594-fx044gcd	810	18	phase	phase	NN
cord-022594-fx044gcd	810	19	of	of	IN
cord-022594-fx044gcd	810	20	the	the	DT
cord-022594-fx044gcd	810	21	disease	disease	NN
cord-022594-fx044gcd	810	22	.	.	.
cord-022594-fx044gcd	811	1	Treatment	treatment	NN
cord-022594-fx044gcd	811	2	approaches	approach	NNS
cord-022594-fx044gcd	811	3	aimed	aim	VBN
cord-022594-fx044gcd	811	4	to	to	TO
cord-022594-fx044gcd	811	5	affect	affect	VB
cord-022594-fx044gcd	811	6	the	the	DT
cord-022594-fx044gcd	811	7	natural	natural	JJ
cord-022594-fx044gcd	811	8	course	course	NN
cord-022594-fx044gcd	811	9	of	of	IN
cord-022594-fx044gcd	811	10	disease	disease	NN
cord-022594-fx044gcd	811	11	are	be	VBP
cord-022594-fx044gcd	811	12	available	available	JJ
cord-022594-fx044gcd	811	13	for	for	IN
cord-022594-fx044gcd	811	14	these	these	DT
cord-022594-fx044gcd	811	15	patients	patient	NNS
cord-022594-fx044gcd	811	16	.	.	.
cord-022594-fx044gcd	812	1	Interferons	interferon	NNS
cord-022594-fx044gcd	812	2	.	.	.
cord-022594-fx044gcd	813	1	Interferon	interferon	NN
cord-022594-fx044gcd	813	2	-	-	HYPH
cord-022594-fx044gcd	813	3	b	b	NN
cord-022594-fx044gcd	813	4	1b	1b	CD
cord-022594-fx044gcd	813	5	may	may	MD
cord-022594-fx044gcd	813	6	have	have	VB
cord-022594-fx044gcd	813	7	a	a	DT
cord-022594-fx044gcd	813	8	beneficial	beneficial	JJ
cord-022594-fx044gcd	813	9	effect	effect	NN
cord-022594-fx044gcd	813	10	on	on	IN
cord-022594-fx044gcd	813	11	the	the	DT
cord-022594-fx044gcd	813	12	overall	overall	JJ
cord-022594-fx044gcd	813	13	outcome	outcome	NN
cord-022594-fx044gcd	813	14	of	of	IN
cord-022594-fx044gcd	813	15	SPMS	SPMS	NNP
cord-022594-fx044gcd	813	16	and	and	CC
cord-022594-fx044gcd	813	17	may	may	MD
cord-022594-fx044gcd	813	18	also	also	RB
cord-022594-fx044gcd	813	19	alter	alter	VB
cord-022594-fx044gcd	813	20	MR	MR	NNP
cord-022594-fx044gcd	813	21	lesions	lesion	NNS
cord-022594-fx044gcd	813	22	,	,	,
cord-022594-fx044gcd	813	23	86	86	CD
cord-022594-fx044gcd	813	24	,	,	,
cord-022594-fx044gcd	813	25	87	87	CD
cord-022594-fx044gcd	813	26	but	but	CC
cord-022594-fx044gcd	813	27	this	this	DT
cord-022594-fx044gcd	813	28	question	question	NN
cord-022594-fx044gcd	813	29	remains	remain	VBZ
cord-022594-fx044gcd	813	30	incompletely	incompletely	RB
cord-022594-fx044gcd	813	31	answered	answer	VBN
cord-022594-fx044gcd	813	32	.	.	.
cord-022594-fx044gcd	814	1	In	in	IN
cord-022594-fx044gcd	814	2	the	the	DT
cord-022594-fx044gcd	814	3	placebo	placebo	NN
cord-022594-fx044gcd	814	4	-	-	HYPH
cord-022594-fx044gcd	814	5	controlled	control	VBN
cord-022594-fx044gcd	814	6	European	european	JJ
cord-022594-fx044gcd	814	7	study	study	NN
cord-022594-fx044gcd	814	8	88	88	CD
cord-022594-fx044gcd	814	9	of	of	IN
cord-022594-fx044gcd	814	10	inteferon	inteferon	NNP
cord-022594-fx044gcd	814	11	-	-	HYPH
cord-022594-fx044gcd	814	12	b	b	NN
cord-022594-fx044gcd	814	13	1b	1b	CD
cord-022594-fx044gcd	814	14	in	in	IN
cord-022594-fx044gcd	814	15	SPMS	SPMS	NNP
cord-022594-fx044gcd	814	16	,	,	,
cord-022594-fx044gcd	814	17	the	the	DT
cord-022594-fx044gcd	814	18	time	time	NN
cord-022594-fx044gcd	814	19	to	to	IN
cord-022594-fx044gcd	814	20	worsening	worsen	VBG
cord-022594-fx044gcd	814	21	was	be	VBD
cord-022594-fx044gcd	814	22	extended	extend	VBN
cord-022594-fx044gcd	814	23	for	for	IN
cord-022594-fx044gcd	814	24	treated	treat	VBN
cord-022594-fx044gcd	814	25	patients	patient	NNS
cord-022594-fx044gcd	814	26	.	.	.
cord-022594-fx044gcd	815	1	Treated	treat	VBN
cord-022594-fx044gcd	815	2	patients	patient	NNS
cord-022594-fx044gcd	815	3	were	be	VBD
cord-022594-fx044gcd	815	4	less	less	RBR
cord-022594-fx044gcd	815	5	likely	likely	JJ
cord-022594-fx044gcd	815	6	to	to	TO
cord-022594-fx044gcd	815	7	be	be	VB
cord-022594-fx044gcd	815	8	wheelchair	wheelchair	NN
cord-022594-fx044gcd	815	9	-	-	HYPH
cord-022594-fx044gcd	815	10	bound	bind	VBN
cord-022594-fx044gcd	815	11	and	and	CC
cord-022594-fx044gcd	815	12	had	have	VBD
cord-022594-fx044gcd	815	13	fewer	few	JJR
cord-022594-fx044gcd	815	14	hospitalizations	hospitalization	NNS
cord-022594-fx044gcd	815	15	.	.	.
cord-022594-fx044gcd	816	1	Another	another	DT
cord-022594-fx044gcd	816	2	analysis	analysis	NN
cord-022594-fx044gcd	816	3	89	89	CD
cord-022594-fx044gcd	816	4	of	of	IN
cord-022594-fx044gcd	816	5	this	this	DT
cord-022594-fx044gcd	816	6	study	study	NN
cord-022594-fx044gcd	816	7	confirmed	confirm	VBD
cord-022594-fx044gcd	816	8	the	the	DT
cord-022594-fx044gcd	816	9	benefits	benefit	NNS
cord-022594-fx044gcd	816	10	,	,	,
cord-022594-fx044gcd	816	11	though	though	IN
cord-022594-fx044gcd	816	12	the	the	DT
cord-022594-fx044gcd	816	13	dropout	dropout	NN
cord-022594-fx044gcd	816	14	rate	rate	NN
cord-022594-fx044gcd	816	15	in	in	IN
cord-022594-fx044gcd	816	16	this	this	DT
cord-022594-fx044gcd	816	17	study	study	NN
cord-022594-fx044gcd	816	18	was	be	VBD
cord-022594-fx044gcd	816	19	relatively	relatively	RB
cord-022594-fx044gcd	816	20	high	high	JJ
cord-022594-fx044gcd	816	21	.	.	.
cord-022594-fx044gcd	817	1	The	the	DT
cord-022594-fx044gcd	817	2	patients	patient	NNS
cord-022594-fx044gcd	817	3	who	who	WP
cord-022594-fx044gcd	817	4	responded	respond	VBD
cord-022594-fx044gcd	817	5	best	well	RBS
cord-022594-fx044gcd	817	6	to	to	IN
cord-022594-fx044gcd	817	7	interferon	interferon	NN
cord-022594-fx044gcd	817	8	therapy	therapy	NN
cord-022594-fx044gcd	817	9	were	be	VBD
cord-022594-fx044gcd	817	10	those	those	DT
cord-022594-fx044gcd	817	11	who	who	WP
cord-022594-fx044gcd	817	12	experienced	experience	VBD
cord-022594-fx044gcd	817	13	relapses	relapse	NNS
cord-022594-fx044gcd	817	14	during	during	IN
cord-022594-fx044gcd	817	15	their	-PRON-	PRP$
cord-022594-fx044gcd	817	16	disease	disease	NN
cord-022594-fx044gcd	817	17	course	course	NN
cord-022594-fx044gcd	817	18	.	.	.
cord-022594-fx044gcd	818	1	MRI	MRI	NNP
cord-022594-fx044gcd	818	2	monitoring	monitoring	NN
cord-022594-fx044gcd	818	3	suggested	suggest	VBD
cord-022594-fx044gcd	818	4	that	that	IN
cord-022594-fx044gcd	818	5	the	the	DT
cord-022594-fx044gcd	818	6	benefit	benefit	NN
cord-022594-fx044gcd	818	7	on	on	IN
cord-022594-fx044gcd	818	8	T2	T2	NNP
cord-022594-fx044gcd	818	9	lesion	lesion	NN
cord-022594-fx044gcd	818	10	activity	activity	NN
cord-022594-fx044gcd	818	11	was	be	VBD
cord-022594-fx044gcd	818	12	seen	see	VBN
cord-022594-fx044gcd	818	13	early	early	RB
cord-022594-fx044gcd	818	14	and	and	CC
cord-022594-fx044gcd	818	15	persisted	persist	VBD
cord-022594-fx044gcd	818	16	into	into	IN
cord-022594-fx044gcd	818	17	the	the	DT
cord-022594-fx044gcd	818	18	second	second	JJ
cord-022594-fx044gcd	818	19	half	half	NN
cord-022594-fx044gcd	818	20	of	of	IN
cord-022594-fx044gcd	818	21	the	the	DT
cord-022594-fx044gcd	818	22	second	second	JJ
cord-022594-fx044gcd	818	23	year	year	NN
cord-022594-fx044gcd	818	24	of	of	IN
cord-022594-fx044gcd	818	25	treatment	treatment	NN
cord-022594-fx044gcd	818	26	.	.	.
cord-022594-fx044gcd	819	1	T2	T2	NNP
cord-022594-fx044gcd	819	2	lesion	lesion	NN
cord-022594-fx044gcd	819	3	load	load	NN
cord-022594-fx044gcd	819	4	increased	increase	VBD
cord-022594-fx044gcd	819	5	in	in	IN
cord-022594-fx044gcd	819	6	placebo	placebo	NN
cord-022594-fx044gcd	819	7	-	-	:
cord-022594-fx044gcd	819	8	but	but	CC
cord-022594-fx044gcd	819	9	not	not	RB
cord-022594-fx044gcd	819	10	interferon	interferon	NN
cord-022594-fx044gcd	819	11	-	-	HYPH
cord-022594-fx044gcd	819	12	treated	treat	VBN
cord-022594-fx044gcd	819	13	patients	patient	NNS
cord-022594-fx044gcd	819	14	in	in	IN
cord-022594-fx044gcd	819	15	the	the	DT
cord-022594-fx044gcd	819	16	first	first	JJ
cord-022594-fx044gcd	819	17	2	2	CD
cord-022594-fx044gcd	819	18	years	year	NNS
cord-022594-fx044gcd	819	19	of	of	IN
cord-022594-fx044gcd	819	20	treatment	treatment	NN
cord-022594-fx044gcd	819	21	.	.	.
cord-022594-fx044gcd	820	1	90	90	CD
cord-022594-fx044gcd	821	1	Contrasting	contrast	VBG
cord-022594-fx044gcd	821	2	with	with	IN
cord-022594-fx044gcd	821	3	these	these	DT
cord-022594-fx044gcd	821	4	results	result	NNS
cord-022594-fx044gcd	821	5	,	,	,
cord-022594-fx044gcd	821	6	in	in	IN
cord-022594-fx044gcd	821	7	another	another	DT
cord-022594-fx044gcd	821	8	trial	trial	NN
cord-022594-fx044gcd	821	9	involving	involve	VBG
cord-022594-fx044gcd	821	10	patients	patient	NNS
cord-022594-fx044gcd	821	11	with	with	IN
cord-022594-fx044gcd	821	12	SPMS	SPMS	NNP
cord-022594-fx044gcd	821	13	,	,	,
cord-022594-fx044gcd	821	14	91	91	CD
cord-022594-fx044gcd	821	15	both	both	DT
cord-022594-fx044gcd	821	16	high	high	JJ
cord-022594-fx044gcd	821	17	dose	dose	NN
cord-022594-fx044gcd	821	18	(	(	-LRB-
cord-022594-fx044gcd	821	19	44	44	CD
cord-022594-fx044gcd	821	20	mg	mg	NNP
cord-022594-fx044gcd	821	21	)	)	-RRB-
cord-022594-fx044gcd	821	22	and	and	CC
cord-022594-fx044gcd	821	23	lower	low	JJR
cord-022594-fx044gcd	821	24	dose	dose	NN
cord-022594-fx044gcd	821	25	(	(	-LRB-
cord-022594-fx044gcd	821	26	22	22	CD
cord-022594-fx044gcd	821	27	mg	mg	CD
cord-022594-fx044gcd	821	28	)	)	-RRB-
cord-022594-fx044gcd	822	1	interferon	interferon	NN
cord-022594-fx044gcd	822	2	-	-	HYPH
cord-022594-fx044gcd	822	3	b	b	NNP
cord-022594-fx044gcd	822	4	1a	1a	CD
cord-022594-fx044gcd	822	5	failed	fail	VBD
cord-022594-fx044gcd	822	6	to	to	TO
cord-022594-fx044gcd	822	7	change	change	VB
cord-022594-fx044gcd	822	8	the	the	DT
cord-022594-fx044gcd	822	9	primary	primary	JJ
cord-022594-fx044gcd	822	10	outcome	outcome	NN
cord-022594-fx044gcd	822	11	of	of	IN
cord-022594-fx044gcd	822	12	time	time	NN
cord-022594-fx044gcd	822	13	to	to	IN
cord-022594-fx044gcd	822	14	disability	disability	NN
cord-022594-fx044gcd	822	15	worsening	worsen	VBG
cord-022594-fx044gcd	822	16	.	.	.
cord-022594-fx044gcd	823	1	Positive	positive	JJ
cord-022594-fx044gcd	823	2	effects	effect	NNS
cord-022594-fx044gcd	823	3	were	be	VBD
cord-022594-fx044gcd	823	4	seen	see	VBN
cord-022594-fx044gcd	823	5	on	on	IN
cord-022594-fx044gcd	823	6	relapse	relapse	NN
cord-022594-fx044gcd	823	7	rate	rate	NN
cord-022594-fx044gcd	823	8	and	and	CC
cord-022594-fx044gcd	823	9	reduction	reduction	NN
cord-022594-fx044gcd	823	10	of	of	IN
cord-022594-fx044gcd	823	11	MRI	MRI	NNP
cord-022594-fx044gcd	823	12	activity	activity	NN
cord-022594-fx044gcd	823	13	,	,	,
cord-022594-fx044gcd	823	14	but	but	CC
cord-022594-fx044gcd	823	15	the	the	DT
cord-022594-fx044gcd	823	16	effect	effect	NN
cord-022594-fx044gcd	823	17	on	on	IN
cord-022594-fx044gcd	823	18	disability	disability	NN
cord-022594-fx044gcd	823	19	did	do	VBD
cord-022594-fx044gcd	823	20	not	not	RB
cord-022594-fx044gcd	823	21	replicate	replicate	VB
cord-022594-fx044gcd	823	22	the	the	DT
cord-022594-fx044gcd	823	23	European	european	JJ
cord-022594-fx044gcd	823	24	interferon	interferon	NN
cord-022594-fx044gcd	823	25	-	-	HYPH
cord-022594-fx044gcd	823	26	b	b	NN
cord-022594-fx044gcd	823	27	1b	1b	CD
cord-022594-fx044gcd	823	28	report	report	NN
cord-022594-fx044gcd	823	29	.	.	.
cord-022594-fx044gcd	824	1	A	a	DT
cord-022594-fx044gcd	824	2	combined	combined	JJ
cord-022594-fx044gcd	824	3	analysis	analysis	NN
cord-022594-fx044gcd	824	4	of	of	IN
cord-022594-fx044gcd	824	5	the	the	DT
cord-022594-fx044gcd	824	6	American	american	JJ
cord-022594-fx044gcd	824	7	and	and	CC
cord-022594-fx044gcd	824	8	European	european	JJ
cord-022594-fx044gcd	824	9	trials	trial	NNS
cord-022594-fx044gcd	824	10	concluded	conclude	VBD
cord-022594-fx044gcd	824	11	that	that	IN
cord-022594-fx044gcd	824	12	continued	continue	VBN
cord-022594-fx044gcd	824	13	relapse	relapse	NN
cord-022594-fx044gcd	824	14	activity	activity	NN
cord-022594-fx044gcd	824	15	and	and	CC
cord-022594-fx044gcd	824	16	more	more	RBR
cord-022594-fx044gcd	824	17	rapid	rapid	JJ
cord-022594-fx044gcd	824	18	progression	progression	NN
cord-022594-fx044gcd	824	19	over	over	IN
cord-022594-fx044gcd	824	20	the	the	DT
cord-022594-fx044gcd	824	21	preceding	precede	VBG
cord-022594-fx044gcd	824	22	year	year	NN
cord-022594-fx044gcd	824	23	(	(	-LRB-
cord-022594-fx044gcd	824	24	by	by	IN
cord-022594-fx044gcd	824	25	>	>	XX
cord-022594-fx044gcd	824	26	1	1	CD
cord-022594-fx044gcd	824	27	on	on	IN
cord-022594-fx044gcd	824	28	the	the	DT
cord-022594-fx044gcd	824	29	EDSS	EDSS	NNP
cord-022594-fx044gcd	824	30	scale	scale	NN
cord-022594-fx044gcd	824	31	)	)	-RRB-
cord-022594-fx044gcd	824	32	are	be	VBP
cord-022594-fx044gcd	824	33	the	the	DT
cord-022594-fx044gcd	824	34	best	good	JJS
cord-022594-fx044gcd	824	35	predictors	predictor	NNS
cord-022594-fx044gcd	824	36	of	of	IN
cord-022594-fx044gcd	824	37	response	response	NN
cord-022594-fx044gcd	824	38	.	.	.
cord-022594-fx044gcd	825	1	92	92	CD
cord-022594-fx044gcd	825	2	IVIG	IVIG	NNP
cord-022594-fx044gcd	825	3	in	in	IN
cord-022594-fx044gcd	825	4	Secondary	Secondary	NNP
cord-022594-fx044gcd	825	5	Progressive	Progressive	NNP
cord-022594-fx044gcd	825	6	MS	MS	NNP
cord-022594-fx044gcd	825	7	.	.	.
cord-022594-fx044gcd	826	1	A	a	DT
cord-022594-fx044gcd	826	2	recent	recent	JJ
cord-022594-fx044gcd	826	3	European	european	JJ
cord-022594-fx044gcd	826	4	trial	trial	NN
cord-022594-fx044gcd	826	5	reported	report	VBD
cord-022594-fx044gcd	826	6	that	that	IN
cord-022594-fx044gcd	826	7	IVIG	IVIG	NNP
cord-022594-fx044gcd	826	8	did	do	VBD
cord-022594-fx044gcd	826	9	not	not	RB
cord-022594-fx044gcd	826	10	have	have	VB
cord-022594-fx044gcd	826	11	a	a	DT
cord-022594-fx044gcd	826	12	significant	significant	JJ
cord-022594-fx044gcd	826	13	impact	impact	NN
cord-022594-fx044gcd	826	14	on	on	IN
cord-022594-fx044gcd	826	15	clinical	clinical	JJ
cord-022594-fx044gcd	826	16	and	and	CC
cord-022594-fx044gcd	826	17	disability	disability	NN
cord-022594-fx044gcd	826	18	related	relate	VBN
cord-022594-fx044gcd	826	19	outcome	outcome	NN
cord-022594-fx044gcd	826	20	measures	measure	NNS
cord-022594-fx044gcd	826	21	.	.	.
cord-022594-fx044gcd	827	1	IVIG	IVIG	NNP
cord-022594-fx044gcd	827	2	did	do	VBD
cord-022594-fx044gcd	827	3	reduce	reduce	VB
cord-022594-fx044gcd	827	4	the	the	DT
cord-022594-fx044gcd	827	5	accumulation	accumulation	NN
cord-022594-fx044gcd	827	6	of	of	IN
cord-022594-fx044gcd	827	7	brain	brain	NN
cord-022594-fx044gcd	827	8	atrophy	atrophy	NN
cord-022594-fx044gcd	827	9	in	in	IN
cord-022594-fx044gcd	827	10	SPMS	SPMS	NNP
cord-022594-fx044gcd	827	11	,	,	,
cord-022594-fx044gcd	827	12	but	but	CC
cord-022594-fx044gcd	827	13	did	do	VBD
cord-022594-fx044gcd	827	14	not	not	RB
cord-022594-fx044gcd	827	15	reduce	reduce	VB
cord-022594-fx044gcd	827	16	the	the	DT
cord-022594-fx044gcd	827	17	incidence	incidence	NN
cord-022594-fx044gcd	827	18	of	of	IN
cord-022594-fx044gcd	827	19	blood	blood	NN
cord-022594-fx044gcd	827	20	-	-	HYPH
cord-022594-fx044gcd	827	21	brain	brain	NN
cord-022594-fx044gcd	827	22	barrier	barrier	NN
cord-022594-fx044gcd	827	23	abnormalities	abnormality	NNS
cord-022594-fx044gcd	827	24	.	.	.
cord-022594-fx044gcd	828	1	There	there	EX
cord-022594-fx044gcd	828	2	was	be	VBD
cord-022594-fx044gcd	828	3	no	no	DT
cord-022594-fx044gcd	828	4	statistically	statistically	RB
cord-022594-fx044gcd	828	5	significant	significant	JJ
cord-022594-fx044gcd	828	6	change	change	NN
cord-022594-fx044gcd	828	7	on	on	IN
cord-022594-fx044gcd	828	8	magnetization	magnetization	NN
cord-022594-fx044gcd	828	9	transfer	transfer	NN
cord-022594-fx044gcd	828	10	MRI	mri	NN
cord-022594-fx044gcd	828	11	measurements	measurement	NNS
cord-022594-fx044gcd	828	12	;	;	:
cord-022594-fx044gcd	828	13	however	however	RB
cord-022594-fx044gcd	828	14	,	,	,
cord-022594-fx044gcd	828	15	a	a	DT
cord-022594-fx044gcd	828	16	trend	trend	NN
cord-022594-fx044gcd	828	17	for	for	IN
cord-022594-fx044gcd	828	18	conservation	conservation	NN
cord-022594-fx044gcd	828	19	of	of	IN
cord-022594-fx044gcd	828	20	normal	normal	RB
cord-022594-fx044gcd	828	21	-	-	HYPH
cord-022594-fx044gcd	828	22	appearing	appear	VBG
cord-022594-fx044gcd	828	23	brain	brain	NN
cord-022594-fx044gcd	828	24	tissue	tissue	NN
cord-022594-fx044gcd	828	25	was	be	VBD
cord-022594-fx044gcd	828	26	found	find	VBN
cord-022594-fx044gcd	828	27	.	.	.
cord-022594-fx044gcd	829	1	93	93	CD
cord-022594-fx044gcd	830	1	Overall	overall	JJ
cord-022594-fx044gcd	830	2	Recommendations	Recommendations	NNPS
cord-022594-fx044gcd	830	3	for	for	IN
cord-022594-fx044gcd	830	4	SPMS	SPMS	NNP
cord-022594-fx044gcd	830	5	.	.	.
cord-022594-fx044gcd	831	1	In	in	IN
cord-022594-fx044gcd	831	2	general	general	JJ
cord-022594-fx044gcd	831	3	,	,	,
cord-022594-fx044gcd	831	4	as	as	IN
cord-022594-fx044gcd	831	5	the	the	DT
cord-022594-fx044gcd	831	6	evidence	evidence	NN
cord-022594-fx044gcd	831	7	that	that	IN
cord-022594-fx044gcd	831	8	interferons	interferon	NNS
cord-022594-fx044gcd	831	9	alter	alter	VBP
cord-022594-fx044gcd	831	10	long	long	JJ
cord-022594-fx044gcd	831	11	-	-	HYPH
cord-022594-fx044gcd	831	12	term	term	NN
cord-022594-fx044gcd	831	13	disability	disability	NN
cord-022594-fx044gcd	831	14	is	be	VBZ
cord-022594-fx044gcd	831	15	limited	limited	JJ
cord-022594-fx044gcd	831	16	and	and	CC
cord-022594-fx044gcd	831	17	controversial	controversial	JJ
cord-022594-fx044gcd	831	18	,	,	,
cord-022594-fx044gcd	831	19	we	-PRON-	PRP
cord-022594-fx044gcd	831	20	generally	generally	RB
cord-022594-fx044gcd	831	21	do	do	VBP
cord-022594-fx044gcd	831	22	not	not	RB
cord-022594-fx044gcd	831	23	newly	newly	RB
cord-022594-fx044gcd	831	24	start	start	VB
cord-022594-fx044gcd	831	25	SPMS	SPMS	NNP
cord-022594-fx044gcd	831	26	patients	patient	NNS
cord-022594-fx044gcd	831	27	on	on	IN
cord-022594-fx044gcd	831	28	interferon	interferon	NN
cord-022594-fx044gcd	831	29	products	product	NNS
cord-022594-fx044gcd	831	30	.	.	.
cord-022594-fx044gcd	832	1	In	in	IN
cord-022594-fx044gcd	832	2	a	a	DT
cord-022594-fx044gcd	832	3	subset	subset	NN
cord-022594-fx044gcd	832	4	of	of	IN
cord-022594-fx044gcd	832	5	patients	patient	NNS
cord-022594-fx044gcd	832	6	still	still	RB
cord-022594-fx044gcd	832	7	having	have	VBG
cord-022594-fx044gcd	832	8	disabling	disable	VBG
cord-022594-fx044gcd	832	9	relapses	relapse	NNS
cord-022594-fx044gcd	832	10	,	,	,
cord-022594-fx044gcd	832	11	interferon	interferon	NN
cord-022594-fx044gcd	832	12	therapy	therapy	NN
cord-022594-fx044gcd	832	13	may	may	MD
cord-022594-fx044gcd	832	14	be	be	VB
cord-022594-fx044gcd	832	15	offered	offer	VBN
cord-022594-fx044gcd	832	16	to	to	TO
cord-022594-fx044gcd	832	17	specifically	specifically	RB
cord-022594-fx044gcd	832	18	reduce	reduce	VB
cord-022594-fx044gcd	832	19	relapse	relapse	NN
cord-022594-fx044gcd	832	20	rate	rate	NN
cord-022594-fx044gcd	832	21	.	.	.
cord-022594-fx044gcd	833	1	The	the	DT
cord-022594-fx044gcd	833	2	data	datum	NNS
cord-022594-fx044gcd	833	3	by	by	IN
cord-022594-fx044gcd	833	4	Confavreux	Confavreux	NNP
cord-022594-fx044gcd	833	5	and	and	CC
cord-022594-fx044gcd	833	6	associates	associate	NNS
cord-022594-fx044gcd	833	7	,	,	,
cord-022594-fx044gcd	833	8	however	however	RB
cord-022594-fx044gcd	833	9	,	,	,
cord-022594-fx044gcd	833	10	suggest	suggest	VBP
cord-022594-fx044gcd	833	11	that	that	IN
cord-022594-fx044gcd	833	12	the	the	DT
cord-022594-fx044gcd	833	13	EDSS	EDSS	NNP
cord-022594-fx044gcd	833	14	in	in	IN
cord-022594-fx044gcd	833	15	populations	population	NNS
cord-022594-fx044gcd	833	16	of	of	IN
cord-022594-fx044gcd	833	17	SPMS	SPMS	NNP
cord-022594-fx044gcd	833	18	patients	patient	NNS
cord-022594-fx044gcd	833	19	continues	continue	VBZ
cord-022594-fx044gcd	833	20	to	to	TO
cord-022594-fx044gcd	833	21	progress	progress	VB
cord-022594-fx044gcd	833	22	independent	independent	JJ
cord-022594-fx044gcd	833	23	of	of	IN
cord-022594-fx044gcd	833	24	relapses	relapse	NNS
cord-022594-fx044gcd	833	25	94	94	CD
cord-022594-fx044gcd	833	26	once	once	IN
cord-022594-fx044gcd	833	27	a	a	DT
cord-022594-fx044gcd	833	28	"	"	``
cord-022594-fx044gcd	833	29	fixed	fix	VBN
cord-022594-fx044gcd	833	30	"	"	''
cord-022594-fx044gcd	833	31	baseline	baseline	JJ
cord-022594-fx044gcd	833	32	level	level	NN
cord-022594-fx044gcd	833	33	of	of	IN
cord-022594-fx044gcd	833	34	moderate	moderate	JJ
cord-022594-fx044gcd	833	35	disability	disability	NN
cord-022594-fx044gcd	833	36	has	have	VBZ
cord-022594-fx044gcd	833	37	been	be	VBN
cord-022594-fx044gcd	833	38	reached	reach	VBN
cord-022594-fx044gcd	833	39	.	.	.
cord-022594-fx044gcd	834	1	Therefore	therefore	RB
cord-022594-fx044gcd	834	2	,	,	,
cord-022594-fx044gcd	834	3	while	while	IN
cord-022594-fx044gcd	834	4	interferons	interferon	NNS
cord-022594-fx044gcd	834	5	may	may	MD
cord-022594-fx044gcd	834	6	reduce	reduce	VB
cord-022594-fx044gcd	834	7	the	the	DT
cord-022594-fx044gcd	834	8	relapse	relapse	NN
cord-022594-fx044gcd	834	9	rate	rate	NN
cord-022594-fx044gcd	834	10	in	in	IN
cord-022594-fx044gcd	834	11	SPMS	SPMS	NNP
cord-022594-fx044gcd	834	12	,	,	,
cord-022594-fx044gcd	834	13	the	the	DT
cord-022594-fx044gcd	834	14	rate	rate	NN
cord-022594-fx044gcd	834	15	of	of	IN
cord-022594-fx044gcd	834	16	progression	progression	NN
cord-022594-fx044gcd	834	17	of	of	IN
cord-022594-fx044gcd	834	18	disability	disability	NN
cord-022594-fx044gcd	834	19	may	may	MD
cord-022594-fx044gcd	834	20	not	not	RB
cord-022594-fx044gcd	834	21	be	be	VB
cord-022594-fx044gcd	834	22	reduced	reduce	VBN
cord-022594-fx044gcd	834	23	by	by	IN
cord-022594-fx044gcd	834	24	these	these	DT
cord-022594-fx044gcd	834	25	treatments	treatment	NNS
cord-022594-fx044gcd	834	26	.	.	.
cord-022594-fx044gcd	835	1	More	more	RBR
cord-022594-fx044gcd	835	2	usually	usually	RB
cord-022594-fx044gcd	835	3	,	,	,
cord-022594-fx044gcd	835	4	SPMS	SPMS	NNP
cord-022594-fx044gcd	835	5	patients	patient	NNS
cord-022594-fx044gcd	835	6	are	be	VBP
cord-022594-fx044gcd	835	7	already	already	RB
cord-022594-fx044gcd	835	8	on	on	IN
cord-022594-fx044gcd	835	9	an	an	DT
cord-022594-fx044gcd	835	10	injectable	injectable	JJ
cord-022594-fx044gcd	835	11	immunomodulator	immunomodulator	NN
cord-022594-fx044gcd	835	12	,	,	,
cord-022594-fx044gcd	835	13	and	and	CC
cord-022594-fx044gcd	835	14	the	the	DT
cord-022594-fx044gcd	835	15	question	question	NN
cord-022594-fx044gcd	835	16	of	of	IN
cord-022594-fx044gcd	835	17	whether	whether	IN
cord-022594-fx044gcd	835	18	it	-PRON-	PRP
cord-022594-fx044gcd	835	19	is	be	VBZ
cord-022594-fx044gcd	835	20	worth	worth	JJ
cord-022594-fx044gcd	835	21	continuing	continue	VBG
cord-022594-fx044gcd	835	22	the	the	DT
cord-022594-fx044gcd	835	23	therapy	therapy	NN
cord-022594-fx044gcd	835	24	may	may	MD
cord-022594-fx044gcd	835	25	come	come	VB
cord-022594-fx044gcd	835	26	up	up	RP
cord-022594-fx044gcd	835	27	,	,	,
cord-022594-fx044gcd	835	28	especially	especially	RB
cord-022594-fx044gcd	835	29	in	in	IN
cord-022594-fx044gcd	835	30	patients	patient	NNS
cord-022594-fx044gcd	835	31	who	who	WP
cord-022594-fx044gcd	835	32	have	have	VBP
cord-022594-fx044gcd	835	33	a	a	DT
cord-022594-fx044gcd	835	34	hard	hard	JJ
cord-022594-fx044gcd	835	35	time	time	NN
cord-022594-fx044gcd	835	36	tolerating	tolerate	VBG
cord-022594-fx044gcd	835	37	these	these	DT
cord-022594-fx044gcd	835	38	medications	medication	NNS
cord-022594-fx044gcd	835	39	and	and	CC
cord-022594-fx044gcd	835	40	feel	feel	VBP
cord-022594-fx044gcd	835	41	that	that	IN
cord-022594-fx044gcd	835	42	the	the	DT
cord-022594-fx044gcd	835	43	side	side	NN
cord-022594-fx044gcd	835	44	effects	effect	NNS
cord-022594-fx044gcd	835	45	of	of	IN
cord-022594-fx044gcd	835	46	the	the	DT
cord-022594-fx044gcd	835	47	medications	medication	NNS
cord-022594-fx044gcd	835	48	have	have	VBP
cord-022594-fx044gcd	835	49	a	a	DT
cord-022594-fx044gcd	835	50	clear	clear	JJ
cord-022594-fx044gcd	835	51	negative	negative	JJ
cord-022594-fx044gcd	835	52	impact	impact	NN
cord-022594-fx044gcd	835	53	on	on	IN
cord-022594-fx044gcd	835	54	their	-PRON-	PRP$
cord-022594-fx044gcd	835	55	overall	overall	JJ
cord-022594-fx044gcd	835	56	health	health	NN
cord-022594-fx044gcd	835	57	.	.	.
cord-022594-fx044gcd	836	1	In	in	IN
cord-022594-fx044gcd	836	2	these	these	DT
cord-022594-fx044gcd	836	3	cases	case	NNS
cord-022594-fx044gcd	836	4	,	,	,
cord-022594-fx044gcd	836	5	we	-PRON-	PRP
cord-022594-fx044gcd	836	6	usually	usually	RB
cord-022594-fx044gcd	836	7	allow	allow	VBP
cord-022594-fx044gcd	836	8	the	the	DT
cord-022594-fx044gcd	836	9	patients	patient	NNS
cord-022594-fx044gcd	836	10	to	to	TO
cord-022594-fx044gcd	836	11	stop	stop	VB
cord-022594-fx044gcd	836	12	their	-PRON-	PRP$
cord-022594-fx044gcd	836	13	medications	medication	NNS
cord-022594-fx044gcd	836	14	.	.	.
cord-022594-fx044gcd	837	1	Just	just	RB
cord-022594-fx044gcd	837	2	like	like	IN
cord-022594-fx044gcd	837	3	in	in	IN
cord-022594-fx044gcd	837	4	the	the	DT
cord-022594-fx044gcd	837	5	RRMS	RRMS	NNP
cord-022594-fx044gcd	837	6	cases	case	NNS
cord-022594-fx044gcd	837	7	,	,	,
cord-022594-fx044gcd	837	8	however	however	RB
cord-022594-fx044gcd	837	9	,	,	,
cord-022594-fx044gcd	837	10	patient	patient	JJ
cord-022594-fx044gcd	837	11	education	education	NN
cord-022594-fx044gcd	837	12	about	about	IN
cord-022594-fx044gcd	837	13	SPMS	SPMS	NNP
cord-022594-fx044gcd	837	14	trials	trial	NNS
cord-022594-fx044gcd	837	15	and	and	CC
cord-022594-fx044gcd	837	16	realistic	realistic	JJ
cord-022594-fx044gcd	837	17	expectations	expectation	NNS
cord-022594-fx044gcd	837	18	about	about	IN
cord-022594-fx044gcd	837	19	the	the	DT
cord-022594-fx044gcd	837	20	treatment	treatment	NN
cord-022594-fx044gcd	837	21	is	be	VBZ
cord-022594-fx044gcd	837	22	a	a	DT
cord-022594-fx044gcd	837	23	crucial	crucial	JJ
cord-022594-fx044gcd	837	24	element	element	NN
cord-022594-fx044gcd	837	25	in	in	IN
cord-022594-fx044gcd	837	26	the	the	DT
cord-022594-fx044gcd	837	27	decision	decision	NN
cord-022594-fx044gcd	837	28	-	-	HYPH
cord-022594-fx044gcd	837	29	making	make	VBG
cord-022594-fx044gcd	837	30	process	process	NN
cord-022594-fx044gcd	837	31	.	.	.
cord-022594-fx044gcd	838	1	Understanding	understand	VBG
cord-022594-fx044gcd	838	2	the	the	DT
cord-022594-fx044gcd	838	3	patient	patient	NN
cord-022594-fx044gcd	838	4	's	's	POS
cord-022594-fx044gcd	838	5	needs	need	NNS
cord-022594-fx044gcd	838	6	and	and	CC
cord-022594-fx044gcd	838	7	fears	fear	NNS
cord-022594-fx044gcd	838	8	and	and	CC
cord-022594-fx044gcd	838	9	clarifying	clarify	VBG
cord-022594-fx044gcd	838	10	potential	potential	JJ
cord-022594-fx044gcd	838	11	misconceptions	misconception	NNS
cord-022594-fx044gcd	838	12	constitute	constitute	VBP
cord-022594-fx044gcd	838	13	a	a	DT
cord-022594-fx044gcd	838	14	very	very	RB
cord-022594-fx044gcd	838	15	important	important	JJ
cord-022594-fx044gcd	838	16	role	role	NN
cord-022594-fx044gcd	838	17	of	of	IN
cord-022594-fx044gcd	838	18	the	the	DT
cord-022594-fx044gcd	838	19	treating	treat	VBG
cord-022594-fx044gcd	838	20	neurologist	neurologist	NN
cord-022594-fx044gcd	838	21	.	.	.
cord-022594-fx044gcd	839	1	In	in	IN
cord-022594-fx044gcd	839	2	those	those	DT
cord-022594-fx044gcd	839	3	patients	patient	NNS
cord-022594-fx044gcd	839	4	who	who	WP
cord-022594-fx044gcd	839	5	continue	continue	VBP
cord-022594-fx044gcd	839	6	their	-PRON-	PRP$
cord-022594-fx044gcd	839	7	interferon	interferon	NN
cord-022594-fx044gcd	839	8	therapy	therapy	NN
cord-022594-fx044gcd	839	9	,	,	,
cord-022594-fx044gcd	839	10	we	-PRON-	PRP
cord-022594-fx044gcd	839	11	must	must	MD
cord-022594-fx044gcd	839	12	continue	continue	VB
cord-022594-fx044gcd	839	13	to	to	TO
cord-022594-fx044gcd	839	14	follow	follow	VB
cord-022594-fx044gcd	839	15	them	-PRON-	PRP
cord-022594-fx044gcd	839	16	for	for	IN
cord-022594-fx044gcd	839	17	toxicity	toxicity	NN
cord-022594-fx044gcd	839	18	and	and	CC
cord-022594-fx044gcd	839	19	disease	disease	NN
cord-022594-fx044gcd	839	20	activity	activity	NN
cord-022594-fx044gcd	839	21	.	.	.
cord-022594-fx044gcd	840	1	Please	please	UH
cord-022594-fx044gcd	840	2	also	also	RB
cord-022594-fx044gcd	840	3	see	see	VB
cord-022594-fx044gcd	840	4	the	the	DT
cord-022594-fx044gcd	840	5	following	follow	VBG
cord-022594-fx044gcd	840	6	discussion	discussion	NN
cord-022594-fx044gcd	840	7	under	under	IN
cord-022594-fx044gcd	840	8	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	840	9	for	for	IN
cord-022594-fx044gcd	840	10	recommendations	recommendation	NNS
cord-022594-fx044gcd	840	11	on	on	IN
cord-022594-fx044gcd	840	12	the	the	DT
cord-022594-fx044gcd	840	13	potential	potential	JJ
cord-022594-fx044gcd	840	14	use	use	NN
cord-022594-fx044gcd	840	15	of	of	IN
cord-022594-fx044gcd	840	16	that	that	DT
cord-022594-fx044gcd	840	17	specific	specific	JJ
cord-022594-fx044gcd	840	18	agent	agent	NN
cord-022594-fx044gcd	840	19	in	in	IN
cord-022594-fx044gcd	840	20	SPMS	SPMS	NNP
cord-022594-fx044gcd	840	21	.	.	.
cord-022594-fx044gcd	841	1	Mitoxantrone	Mitoxantrone	NNP
cord-022594-fx044gcd	841	2	.	.	.
cord-022594-fx044gcd	842	1	Mitoxantrone	Mitoxantrone	NNP
cord-022594-fx044gcd	842	2	(	(	-LRB-
cord-022594-fx044gcd	842	3	Novantrone	Novantrone	NNP
cord-022594-fx044gcd	842	4	)	)	-RRB-
cord-022594-fx044gcd	842	5	is	be	VBZ
cord-022594-fx044gcd	842	6	an	an	DT
cord-022594-fx044gcd	842	7	anthracenedione	anthracenedione	NN
cord-022594-fx044gcd	842	8	chemotherapeutic	chemotherapeutic	JJ
cord-022594-fx044gcd	842	9	agent	agent	NN
cord-022594-fx044gcd	842	10	licensed	license	VBN
cord-022594-fx044gcd	842	11	.	.	.
cord-022594-fx044gcd	842	12	.	.	.
cord-022594-fx044gcd	843	1	.for	.for	.
cord-022594-fx044gcd	844	1	reducing	reduce	VBG
cord-022594-fx044gcd	844	2	neurologic	neurologic	JJ
cord-022594-fx044gcd	844	3	disability	disability	NN
cord-022594-fx044gcd	844	4	and/or	and/or	CC
cord-022594-fx044gcd	844	5	the	the	DT
cord-022594-fx044gcd	844	6	frequency	frequency	NN
cord-022594-fx044gcd	844	7	of	of	IN
cord-022594-fx044gcd	844	8	clinical	clinical	JJ
cord-022594-fx044gcd	844	9	relapses	relapse	NNS
cord-022594-fx044gcd	844	10	in	in	IN
cord-022594-fx044gcd	844	11	patients	patient	NNS
cord-022594-fx044gcd	844	12	with	with	IN
cord-022594-fx044gcd	844	13	secondary	secondary	JJ
cord-022594-fx044gcd	844	14	(	(	-LRB-
cord-022594-fx044gcd	844	15	chronic	chronic	JJ
cord-022594-fx044gcd	844	16	)	)	-RRB-
cord-022594-fx044gcd	844	17	progressive	progressive	JJ
cord-022594-fx044gcd	844	18	,	,	,
cord-022594-fx044gcd	844	19	progressive	progressive	JJ
cord-022594-fx044gcd	844	20	relapsing	relapsing	NN
cord-022594-fx044gcd	844	21	,	,	,
cord-022594-fx044gcd	844	22	or	or	CC
cord-022594-fx044gcd	844	23	worsening	worsen	VBG
cord-022594-fx044gcd	844	24	relapsing	relapse	VBG
cord-022594-fx044gcd	844	25	-	-	HYPH
cord-022594-fx044gcd	844	26	remitting	remit	VBG
cord-022594-fx044gcd	844	27	multiple	multiple	JJ
cord-022594-fx044gcd	844	28	sclerosis	sclerosis	NN
cord-022594-fx044gcd	844	29	(	(	-LRB-
cord-022594-fx044gcd	844	30	i.e.	i.e.	FW
cord-022594-fx044gcd	844	31	patients	patient	NNS
cord-022594-fx044gcd	844	32	whose	whose	WP$
cord-022594-fx044gcd	844	33	neurologic	neurologic	JJ
cord-022594-fx044gcd	844	34	status	status	NN
cord-022594-fx044gcd	844	35	is	be	VBZ
cord-022594-fx044gcd	844	36	significantly	significantly	RB
cord-022594-fx044gcd	844	37	abnormal	abnormal	JJ
cord-022594-fx044gcd	844	38	between	between	IN
cord-022594-fx044gcd	844	39	relapses	relapse	NNS
cord-022594-fx044gcd	844	40	)	)	-RRB-
cord-022594-fx044gcd	844	41	.	.	.
cord-022594-fx044gcd	845	1	Mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	845	2	is	be	VBZ
cord-022594-fx044gcd	845	3	not	not	RB
cord-022594-fx044gcd	845	4	indicated	indicate	VBN
cord-022594-fx044gcd	845	5	in	in	IN
cord-022594-fx044gcd	845	6	treatment	treatment	NN
cord-022594-fx044gcd	845	7	of	of	IN
cord-022594-fx044gcd	845	8	patients	patient	NNS
cord-022594-fx044gcd	845	9	with	with	IN
cord-022594-fx044gcd	845	10	primary	primary	JJ
cord-022594-fx044gcd	845	11	progressive	progressive	JJ
cord-022594-fx044gcd	845	12	multiple	multiple	JJ
cord-022594-fx044gcd	845	13	sclerosis	sclerosis	NN
cord-022594-fx044gcd	845	14	.	.	.
cord-022594-fx044gcd	846	1	Significant	significant	JJ
cord-022594-fx044gcd	846	2	benefits	benefit	NNS
cord-022594-fx044gcd	846	3	were	be	VBD
cord-022594-fx044gcd	846	4	observed	observe	VBN
cord-022594-fx044gcd	846	5	in	in	IN
cord-022594-fx044gcd	846	6	a	a	DT
cord-022594-fx044gcd	846	7	group	group	NN
cord-022594-fx044gcd	846	8	of	of	IN
cord-022594-fx044gcd	846	9	SPMS	SPMS	NNP
cord-022594-fx044gcd	846	10	patients	patient	NNS
cord-022594-fx044gcd	846	11	as	as	IN
cord-022594-fx044gcd	846	12	in	in	IN
cord-022594-fx044gcd	846	13	a	a	DT
cord-022594-fx044gcd	846	14	European	european	JJ
cord-022594-fx044gcd	846	15	phase	phase	NN
cord-022594-fx044gcd	846	16	III	iii	CD
cord-022594-fx044gcd	846	17	study	study	NN
cord-022594-fx044gcd	846	18	of	of	IN
cord-022594-fx044gcd	846	19	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	846	20	.	.	.
cord-022594-fx044gcd	847	1	95	95	CD
cord-022594-fx044gcd	848	1	It	-PRON-	PRP
cord-022594-fx044gcd	848	2	has	have	VBZ
cord-022594-fx044gcd	848	3	also	also	RB
cord-022594-fx044gcd	848	4	been	be	VBN
cord-022594-fx044gcd	848	5	used	use	VBN
cord-022594-fx044gcd	848	6	in	in	IN
cord-022594-fx044gcd	848	7	combination	combination	NN
cord-022594-fx044gcd	848	8	with	with	IN
cord-022594-fx044gcd	848	9	methylprednisolone	methylprednisolone	NNP
cord-022594-fx044gcd	848	10	.	.	.
cord-022594-fx044gcd	849	1	96	96	CD
cord-022594-fx044gcd	850	1	Several	several	JJ
cord-022594-fx044gcd	850	2	clinical	clinical	JJ
cord-022594-fx044gcd	850	3	and	and	CC
cord-022594-fx044gcd	850	4	functional	functional	JJ
cord-022594-fx044gcd	850	5	outcome	outcome	NN
cord-022594-fx044gcd	850	6	measures	measure	NNS
cord-022594-fx044gcd	850	7	were	be	VBD
cord-022594-fx044gcd	850	8	reported	report	VBN
cord-022594-fx044gcd	850	9	to	to	TO
cord-022594-fx044gcd	850	10	stabilize	stabilize	VB
cord-022594-fx044gcd	850	11	or	or	CC
cord-022594-fx044gcd	850	12	improve	improve	VB
cord-022594-fx044gcd	850	13	with	with	IN
cord-022594-fx044gcd	850	14	every	every	DT
cord-022594-fx044gcd	850	15	3-month	3-month	CD
cord-022594-fx044gcd	850	16	administration	administration	NN
cord-022594-fx044gcd	850	17	of	of	IN
cord-022594-fx044gcd	850	18	this	this	DT
cord-022594-fx044gcd	850	19	intravenous	intravenous	JJ
cord-022594-fx044gcd	850	20	medication	medication	NN
cord-022594-fx044gcd	850	21	.	.	.
cord-022594-fx044gcd	851	1	Secondary	secondary	JJ
cord-022594-fx044gcd	851	2	MRI	MRI	NNP
cord-022594-fx044gcd	851	3	outcome	outcome	NN
cord-022594-fx044gcd	851	4	measures	measure	NNS
cord-022594-fx044gcd	851	5	,	,	,
cord-022594-fx044gcd	851	6	including	include	VBG
cord-022594-fx044gcd	851	7	enhancing	enhance	VBG
cord-022594-fx044gcd	851	8	lesion	lesion	NN
cord-022594-fx044gcd	851	9	formation	formation	NN
cord-022594-fx044gcd	851	10	and	and	CC
cord-022594-fx044gcd	851	11	overall	overall	JJ
cord-022594-fx044gcd	851	12	T2	T2	NNP
cord-022594-fx044gcd	851	13	lesion	lesion	NN
cord-022594-fx044gcd	851	14	load	load	NN
cord-022594-fx044gcd	851	15	,	,	,
cord-022594-fx044gcd	851	16	were	be	VBD
cord-022594-fx044gcd	851	17	also	also	RB
cord-022594-fx044gcd	851	18	better	well	JJR
cord-022594-fx044gcd	851	19	in	in	IN
cord-022594-fx044gcd	851	20	the	the	DT
cord-022594-fx044gcd	851	21	treated	treat	VBN
cord-022594-fx044gcd	851	22	patients	patient	NNS
cord-022594-fx044gcd	851	23	.	.	.
cord-022594-fx044gcd	852	1	The	the	DT
cord-022594-fx044gcd	852	2	greatest	great	JJS
cord-022594-fx044gcd	852	3	concern	concern	NN
cord-022594-fx044gcd	852	4	regarding	regard	VBG
cord-022594-fx044gcd	852	5	this	this	DT
cord-022594-fx044gcd	852	6	medication	medication	NN
cord-022594-fx044gcd	852	7	is	be	VBZ
cord-022594-fx044gcd	852	8	its	-PRON-	PRP$
cord-022594-fx044gcd	852	9	cardiac	cardiac	JJ
cord-022594-fx044gcd	852	10	toxicity	toxicity	NN
cord-022594-fx044gcd	852	11	:	:	:
cord-022594-fx044gcd	852	12	the	the	DT
cord-022594-fx044gcd	852	13	cumulative	cumulative	JJ
cord-022594-fx044gcd	852	14	lifetime	lifetime	NN
cord-022594-fx044gcd	852	15	maximum	maximum	NN
cord-022594-fx044gcd	852	16	dose	dose	NN
cord-022594-fx044gcd	852	17	was	be	VBD
cord-022594-fx044gcd	852	18	established	establish	VBN
cord-022594-fx044gcd	852	19	at	at	IN
cord-022594-fx044gcd	852	20	140	140	CD
cord-022594-fx044gcd	852	21	mg	mg	NNP
cord-022594-fx044gcd	852	22	/	/	SYM
cord-022594-fx044gcd	852	23	m	m	NN
cord-022594-fx044gcd	852	24	2	2	CD
cord-022594-fx044gcd	852	25	.	.	.
cord-022594-fx044gcd	853	1	Mitoxantrone	Mitoxantrone	NNP
cord-022594-fx044gcd	853	2	can	can	MD
cord-022594-fx044gcd	853	3	induce	induce	VB
cord-022594-fx044gcd	853	4	a	a	DT
cord-022594-fx044gcd	853	5	seemingly	seemingly	RB
cord-022594-fx044gcd	853	6	dose	dose	NN
cord-022594-fx044gcd	853	7	-	-	HYPH
cord-022594-fx044gcd	853	8	dependent	dependent	JJ
cord-022594-fx044gcd	853	9	cardiomyopathy	cardiomyopathy	NN
cord-022594-fx044gcd	853	10	,	,	,
cord-022594-fx044gcd	853	11	leading	lead	VBG
cord-022594-fx044gcd	853	12	to	to	IN
cord-022594-fx044gcd	853	13	potentially	potentially	RB
cord-022594-fx044gcd	853	14	fatal	fatal	JJ
cord-022594-fx044gcd	853	15	congestive	congestive	JJ
cord-022594-fx044gcd	853	16	heart	heart	NN
cord-022594-fx044gcd	853	17	failure	failure	NN
cord-022594-fx044gcd	853	18	.	.	.
cord-022594-fx044gcd	854	1	We	-PRON-	PRP
cord-022594-fx044gcd	854	2	generally	generally	RB
cord-022594-fx044gcd	854	3	avoid	avoid	VBP
cord-022594-fx044gcd	854	4	exceeding	exceed	VBG
cord-022594-fx044gcd	854	5	a	a	DT
cord-022594-fx044gcd	854	6	total	total	JJ
cord-022594-fx044gcd	854	7	lifetime	lifetime	NN
cord-022594-fx044gcd	854	8	dose	dose	NN
cord-022594-fx044gcd	854	9	of	of	IN
cord-022594-fx044gcd	854	10	96	96	CD
cord-022594-fx044gcd	854	11	mg	mg	NNP
cord-022594-fx044gcd	854	12	/	/	SYM
cord-022594-fx044gcd	854	13	m	m	NN
cord-022594-fx044gcd	854	14	2	2	CD
cord-022594-fx044gcd	854	15	(	(	-LRB-
cord-022594-fx044gcd	854	16	8	8	CD
cord-022594-fx044gcd	854	17	doses	dose	NNS
cord-022594-fx044gcd	854	18	of	of	IN
cord-022594-fx044gcd	854	19	12	12	CD
cord-022594-fx044gcd	854	20	mg	mg	NNP
cord-022594-fx044gcd	854	21	/	/	SYM
cord-022594-fx044gcd	854	22	m	m	NNP
cord-022594-fx044gcd	854	23	2	2	CD
cord-022594-fx044gcd	854	24	)	)	-RRB-
cord-022594-fx044gcd	854	25	.	.	.
cord-022594-fx044gcd	855	1	Patients	patient	NNS
cord-022594-fx044gcd	855	2	receiving	receive	VBG
cord-022594-fx044gcd	855	3	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	855	4	should	should	MD
cord-022594-fx044gcd	855	5	also	also	RB
cord-022594-fx044gcd	855	6	be	be	VB
cord-022594-fx044gcd	855	7	monitored	monitor	VBN
cord-022594-fx044gcd	855	8	every	every	DT
cord-022594-fx044gcd	855	9	3	3	CD
cord-022594-fx044gcd	855	10	months	month	NNS
cord-022594-fx044gcd	855	11	with	with	IN
cord-022594-fx044gcd	855	12	echocardiograms	echocardiogram	NNS
cord-022594-fx044gcd	855	13	or	or	CC
cord-022594-fx044gcd	855	14	MUGA	MUGA	NNP
cord-022594-fx044gcd	855	15	(	(	-LRB-
cord-022594-fx044gcd	855	16	multiple	multiple	JJ
cord-022594-fx044gcd	855	17	gated	gated	JJ
cord-022594-fx044gcd	855	18	acquisition	acquisition	NN
cord-022594-fx044gcd	855	19	)	)	-RRB-
cord-022594-fx044gcd	855	20	scans	scan	NNS
cord-022594-fx044gcd	855	21	to	to	TO
cord-022594-fx044gcd	855	22	determine	determine	VB
cord-022594-fx044gcd	855	23	the	the	DT
cord-022594-fx044gcd	855	24	ejection	ejection	NN
cord-022594-fx044gcd	855	25	fraction	fraction	NN
cord-022594-fx044gcd	855	26	.	.	.
cord-022594-fx044gcd	856	1	Reduction	reduction	NN
cord-022594-fx044gcd	856	2	in	in	IN
cord-022594-fx044gcd	856	3	the	the	DT
cord-022594-fx044gcd	856	4	ejection	ejection	NN
cord-022594-fx044gcd	856	5	fraction	fraction	NN
cord-022594-fx044gcd	856	6	should	should	MD
cord-022594-fx044gcd	856	7	prompt	prompt	VB
cord-022594-fx044gcd	856	8	discontinuation	discontinuation	NN
cord-022594-fx044gcd	856	9	of	of	IN
cord-022594-fx044gcd	856	10	this	this	DT
cord-022594-fx044gcd	856	11	therapy	therapy	NN
cord-022594-fx044gcd	856	12	.	.	.
cord-022594-fx044gcd	857	1	Besides	besides	IN
cord-022594-fx044gcd	857	2	the	the	DT
cord-022594-fx044gcd	857	3	cardiac	cardiac	JJ
cord-022594-fx044gcd	857	4	side	side	NN
cord-022594-fx044gcd	857	5	effects	effect	NNS
cord-022594-fx044gcd	857	6	,	,	,
cord-022594-fx044gcd	857	7	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	857	8	may	may	MD
cord-022594-fx044gcd	857	9	cause	cause	VB
cord-022594-fx044gcd	857	10	menstrual	menstrual	JJ
cord-022594-fx044gcd	857	11	irregularities	irregularity	NNS
cord-022594-fx044gcd	857	12	or	or	CC
cord-022594-fx044gcd	857	13	overall	overall	JJ
cord-022594-fx044gcd	857	14	ablation	ablation	NN
cord-022594-fx044gcd	857	15	of	of	IN
cord-022594-fx044gcd	857	16	the	the	DT
cord-022594-fx044gcd	857	17	menstrual	menstrual	JJ
cord-022594-fx044gcd	857	18	cycle	cycle	NN
cord-022594-fx044gcd	857	19	,	,	,
cord-022594-fx044gcd	857	20	which	which	WDT
cord-022594-fx044gcd	857	21	may	may	MD
cord-022594-fx044gcd	857	22	be	be	VB
cord-022594-fx044gcd	857	23	permanent	permanent	JJ
cord-022594-fx044gcd	857	24	.	.	.
cord-022594-fx044gcd	858	1	In	in	IN
cord-022594-fx044gcd	858	2	a	a	DT
cord-022594-fx044gcd	858	3	review	review	NN
cord-022594-fx044gcd	858	4	of	of	IN
cord-022594-fx044gcd	858	5	the	the	DT
cord-022594-fx044gcd	858	6	literature	literature	NN
cord-022594-fx044gcd	858	7	,	,	,
cord-022594-fx044gcd	858	8	Ghalie	Ghalie	NNP
cord-022594-fx044gcd	858	9	97	97	CD
cord-022594-fx044gcd	858	10	estimated	estimate	VBD
cord-022594-fx044gcd	858	11	the	the	DT
cord-022594-fx044gcd	858	12	risk	risk	NN
cord-022594-fx044gcd	858	13	of	of	IN
cord-022594-fx044gcd	858	14	mitoxantrone	mitoxantrone	NNP
cord-022594-fx044gcd	858	15	therapyrelated	therapyrelate	VBD
cord-022594-fx044gcd	858	16	acute	acute	JJ
cord-022594-fx044gcd	858	17	leukemia	leukemia	NN
cord-022594-fx044gcd	858	18	in	in	IN
cord-022594-fx044gcd	858	19	MS	MS	NNP
cord-022594-fx044gcd	858	20	patients	patient	NNS
cord-022594-fx044gcd	858	21	at	at	IN
cord-022594-fx044gcd	858	22	0.05	0.05	CD
cord-022594-fx044gcd	858	23	%	%	NN
cord-022594-fx044gcd	858	24	to	to	IN
cord-022594-fx044gcd	858	25	0.1	0.1	CD
cord-022594-fx044gcd	858	26	%	%	NN
cord-022594-fx044gcd	858	27	;	;	:
cord-022594-fx044gcd	858	28	in	in	IN
cord-022594-fx044gcd	858	29	an	an	DT
cord-022594-fx044gcd	858	30	international	international	JJ
cord-022594-fx044gcd	858	31	registry	registry	NN
cord-022594-fx044gcd	858	32	of	of	IN
cord-022594-fx044gcd	858	33	MS	MS	NNP
cord-022594-fx044gcd	858	34	patients	patient	NNS
cord-022594-fx044gcd	858	35	taking	take	VBG
cord-022594-fx044gcd	858	36	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	858	37	,	,	,
cord-022594-fx044gcd	858	38	the	the	DT
cord-022594-fx044gcd	858	39	risk	risk	NN
cord-022594-fx044gcd	858	40	of	of	IN
cord-022594-fx044gcd	858	41	leukemia	leukemia	NN
cord-022594-fx044gcd	858	42	seems	seem	VBZ
cord-022594-fx044gcd	858	43	somewhat	somewhat	RB
cord-022594-fx044gcd	858	44	higher	high	JJR
cord-022594-fx044gcd	858	45	.	.	.
cord-022594-fx044gcd	859	1	This	this	DT
cord-022594-fx044gcd	859	2	therapy	therapy	NN
cord-022594-fx044gcd	859	3	has	have	VBZ
cord-022594-fx044gcd	859	4	been	be	VBN
cord-022594-fx044gcd	859	5	approved	approve	VBN
cord-022594-fx044gcd	859	6	by	by	IN
cord-022594-fx044gcd	859	7	the	the	DT
cord-022594-fx044gcd	859	8	FDA	FDA	NNP
cord-022594-fx044gcd	859	9	for	for	IN
cord-022594-fx044gcd	859	10	treatment	treatment	NN
cord-022594-fx044gcd	859	11	of	of	IN
cord-022594-fx044gcd	859	12	SPMS	SPMS	NNP
cord-022594-fx044gcd	859	13	,	,	,
cord-022594-fx044gcd	859	14	but	but	CC
cord-022594-fx044gcd	859	15	no	no	DT
cord-022594-fx044gcd	859	16	peer	peer	NN
cord-022594-fx044gcd	859	17	-	-	HYPH
cord-022594-fx044gcd	859	18	reviewed	review	VBN
cord-022594-fx044gcd	859	19	full	full	JJ
cord-022594-fx044gcd	859	20	report	report	NN
cord-022594-fx044gcd	859	21	of	of	IN
cord-022594-fx044gcd	859	22	the	the	DT
cord-022594-fx044gcd	859	23	MIMS	MIMS	NNP
cord-022594-fx044gcd	859	24	study	study	NN
cord-022594-fx044gcd	859	25	had	have	VBD
cord-022594-fx044gcd	859	26	been	be	VBN
cord-022594-fx044gcd	859	27	published	publish	VBN
cord-022594-fx044gcd	859	28	until	until	IN
cord-022594-fx044gcd	859	29	4	4	CD
cord-022594-fx044gcd	859	30	years	year	NNS
cord-022594-fx044gcd	859	31	after	after	IN
cord-022594-fx044gcd	859	32	the	the	DT
cord-022594-fx044gcd	859	33	initial	initial	JJ
cord-022594-fx044gcd	859	34	report	report	NN
cord-022594-fx044gcd	859	35	in	in	IN
cord-022594-fx044gcd	859	36	an	an	DT
cord-022594-fx044gcd	859	37	abstracts	abstract	NNS
cord-022594-fx044gcd	859	38	form	form	NN
cord-022594-fx044gcd	859	39	.	.	.
cord-022594-fx044gcd	860	1	The	the	DT
cord-022594-fx044gcd	860	2	study	study	NN
cord-022594-fx044gcd	860	3	98	98	CD
cord-022594-fx044gcd	860	4	showed	show	VBD
cord-022594-fx044gcd	860	5	a	a	DT
cord-022594-fx044gcd	860	6	treatment	treatment	NN
cord-022594-fx044gcd	860	7	effect	effect	NN
cord-022594-fx044gcd	860	8	in	in	IN
cord-022594-fx044gcd	860	9	RRMS	RRMS	NNP
cord-022594-fx044gcd	860	10	and	and	CC
cord-022594-fx044gcd	860	11	SPMS	SPMS	NNP
cord-022594-fx044gcd	860	12	patients	patient	NNS
cord-022594-fx044gcd	860	13	with	with	IN
cord-022594-fx044gcd	860	14	"	"	``
cord-022594-fx044gcd	860	15	recent	recent	JJ
cord-022594-fx044gcd	860	16	rapid	rapid	JJ
cord-022594-fx044gcd	860	17	worsening	worsening	NN
cord-022594-fx044gcd	860	18	.	.	.
cord-022594-fx044gcd	861	1	"	"	''
cord-022594-fx044gcd	862	1	The	the	DT
cord-022594-fx044gcd	862	2	study	study	NN
cord-022594-fx044gcd	862	3	had	have	VBD
cord-022594-fx044gcd	862	4	a	a	DT
cord-022594-fx044gcd	862	5	high	high	JJ
cord-022594-fx044gcd	862	6	dropout	dropout	NN
cord-022594-fx044gcd	862	7	rate	rate	NN
cord-022594-fx044gcd	862	8	and	and	CC
cord-022594-fx044gcd	862	9	a	a	DT
cord-022594-fx044gcd	862	10	small	small	JJ
cord-022594-fx044gcd	862	11	sample	sample	NN
cord-022594-fx044gcd	862	12	size	size	NN
cord-022594-fx044gcd	862	13	.	.	.
cord-022594-fx044gcd	863	1	Most	Most	JJS
cord-022594-fx044gcd	863	2	patients	patient	NNS
cord-022594-fx044gcd	863	3	(	(	-LRB-
cord-022594-fx044gcd	863	4	74	74	CD
cord-022594-fx044gcd	863	5	%	%	NN
cord-022594-fx044gcd	863	6	)	)	-RRB-
cord-022594-fx044gcd	863	7	had	have	VBD
cord-022594-fx044gcd	863	8	relapses	relapse	NNS
cord-022594-fx044gcd	863	9	in	in	IN
cord-022594-fx044gcd	863	10	the	the	DT
cord-022594-fx044gcd	863	11	preceding	precede	VBG
cord-022594-fx044gcd	863	12	2	2	CD
cord-022594-fx044gcd	863	13	years	year	NNS
cord-022594-fx044gcd	863	14	,	,	,
cord-022594-fx044gcd	863	15	suggesting	suggest	VBG
cord-022594-fx044gcd	863	16	this	this	DT
cord-022594-fx044gcd	863	17	cohort	cohort	NN
cord-022594-fx044gcd	863	18	mostly	mostly	RB
cord-022594-fx044gcd	863	19	includes	include	VBZ
cord-022594-fx044gcd	863	20	worsening	worsen	VBG
cord-022594-fx044gcd	863	21	RRMS	rrm	NNS
cord-022594-fx044gcd	863	22	or	or	CC
cord-022594-fx044gcd	863	23	PRMS	PRMS	NNP
cord-022594-fx044gcd	863	24	patients	patient	NNS
cord-022594-fx044gcd	863	25	,	,	,
cord-022594-fx044gcd	863	26	in	in	IN
cord-022594-fx044gcd	863	27	whom	whom	WP
cord-022594-fx044gcd	863	28	a	a	DT
cord-022594-fx044gcd	863	29	positive	positive	JJ
cord-022594-fx044gcd	863	30	treatment	treatment	NN
cord-022594-fx044gcd	863	31	effect	effect	NN
cord-022594-fx044gcd	863	32	is	be	VBZ
cord-022594-fx044gcd	863	33	expected	expect	VBN
cord-022594-fx044gcd	863	34	;	;	:
cord-022594-fx044gcd	863	35	however	however	RB
cord-022594-fx044gcd	863	36	,	,	,
cord-022594-fx044gcd	863	37	it	-PRON-	PRP
cord-022594-fx044gcd	863	38	does	do	VBZ
cord-022594-fx044gcd	863	39	not	not	RB
cord-022594-fx044gcd	863	40	mean	mean	VB
cord-022594-fx044gcd	863	41	that	that	IN
cord-022594-fx044gcd	863	42	for	for	IN
cord-022594-fx044gcd	863	43	classic	classic	JJ
cord-022594-fx044gcd	863	44	SPMS	SPMS	NNP
cord-022594-fx044gcd	863	45	patients	patient	NNS
cord-022594-fx044gcd	863	46	who	who	WP
cord-022594-fx044gcd	863	47	no	no	RB
cord-022594-fx044gcd	863	48	longer	longer	RB
cord-022594-fx044gcd	863	49	have	have	VBP
cord-022594-fx044gcd	863	50	relapses	relapse	NNS
cord-022594-fx044gcd	863	51	the	the	DT
cord-022594-fx044gcd	863	52	study	study	NN
cord-022594-fx044gcd	863	53	outcome	outcome	NN
cord-022594-fx044gcd	863	54	is	be	VBZ
cord-022594-fx044gcd	863	55	applicable	applicable	JJ
cord-022594-fx044gcd	863	56	,	,	,
cord-022594-fx044gcd	863	57	and	and	CC
cord-022594-fx044gcd	863	58	it	-PRON-	PRP
cord-022594-fx044gcd	863	59	is	be	VBZ
cord-022594-fx044gcd	863	60	especially	especially	RB
cord-022594-fx044gcd	863	61	not	not	RB
cord-022594-fx044gcd	863	62	applicable	applicable	JJ
cord-022594-fx044gcd	863	63	to	to	IN
cord-022594-fx044gcd	863	64	PPMS	PPMS	NNP
cord-022594-fx044gcd	863	65	cases	case	NNS
cord-022594-fx044gcd	863	66	.	.	.
cord-022594-fx044gcd	864	1	The	the	DT
cord-022594-fx044gcd	864	2	primary	primary	JJ
cord-022594-fx044gcd	864	3	outcome	outcome	NN
cord-022594-fx044gcd	864	4	measure	measure	NN
cord-022594-fx044gcd	864	5	was	be	VBD
cord-022594-fx044gcd	864	6	a	a	DT
cord-022594-fx044gcd	864	7	composite	composite	JJ
cord-022594-fx044gcd	864	8	score	score	NN
cord-022594-fx044gcd	864	9	comprised	comprise	VBN
cord-022594-fx044gcd	864	10	of	of	IN
cord-022594-fx044gcd	864	11	five	five	CD
cord-022594-fx044gcd	864	12	clinical	clinical	JJ
cord-022594-fx044gcd	864	13	measures	measure	NNS
cord-022594-fx044gcd	864	14	:	:	:
cord-022594-fx044gcd	864	15	change	change	VB
cord-022594-fx044gcd	864	16	in	in	IN
cord-022594-fx044gcd	864	17	EDSS	EDSS	NNP
cord-022594-fx044gcd	864	18	at	at	IN
cord-022594-fx044gcd	864	19	2	2	CD
cord-022594-fx044gcd	864	20	years	year	NNS
cord-022594-fx044gcd	864	21	;	;	:
cord-022594-fx044gcd	864	22	change	change	NN
cord-022594-fx044gcd	864	23	in	in	IN
cord-022594-fx044gcd	864	24	Ambulation	Ambulation	NNP
cord-022594-fx044gcd	864	25	Index	Index	NNP
cord-022594-fx044gcd	864	26	at	at	IN
cord-022594-fx044gcd	864	27	2	2	CD
cord-022594-fx044gcd	864	28	years	year	NNS
cord-022594-fx044gcd	864	29	;	;	:
cord-022594-fx044gcd	864	30	change	change	VB
cord-022594-fx044gcd	864	31	in	in	IN
cord-022594-fx044gcd	864	32	the	the	DT
cord-022594-fx044gcd	864	33	baseline	baseline	JJ
cord-022594-fx044gcd	864	34	standardized	standardized	JJ
cord-022594-fx044gcd	864	35	neurological	neurological	JJ
cord-022594-fx044gcd	864	36	status	status	NN
cord-022594-fx044gcd	864	37	at	at	IN
cord-022594-fx044gcd	864	38	2	2	CD
cord-022594-fx044gcd	864	39	years	year	NNS
cord-022594-fx044gcd	864	40	;	;	:
cord-022594-fx044gcd	864	41	number	number	NN
cord-022594-fx044gcd	864	42	of	of	IN
cord-022594-fx044gcd	864	43	relapses	relapse	NNS
cord-022594-fx044gcd	864	44	requiring	require	VBG
cord-022594-fx044gcd	864	45	corticosteroid	corticosteroid	NN
cord-022594-fx044gcd	864	46	treatment	treatment	NN
cord-022594-fx044gcd	864	47	;	;	:
cord-022594-fx044gcd	864	48	and	and	CC
cord-022594-fx044gcd	864	49	time	time	NN
cord-022594-fx044gcd	864	50	to	to	IN
cord-022594-fx044gcd	864	51	first	first	JJ
cord-022594-fx044gcd	864	52	relapse	relapse	VB
cord-022594-fx044gcd	864	53	.	.	.
cord-022594-fx044gcd	865	1	Seventy	seventy	CD
cord-022594-fx044gcd	865	2	-	-	HYPH
cord-022594-fx044gcd	865	3	seven	seven	CD
cord-022594-fx044gcd	865	4	percent	percent	NN
cord-022594-fx044gcd	865	5	completed	complete	VBN
cord-022594-fx044gcd	865	6	24	24	CD
cord-022594-fx044gcd	865	7	months	month	NNS
cord-022594-fx044gcd	865	8	of	of	IN
cord-022594-fx044gcd	865	9	follow	follow	NN
cord-022594-fx044gcd	865	10	-	-	HYPH
cord-022594-fx044gcd	865	11	up	up	NN
cord-022594-fx044gcd	865	12	.	.	.
cord-022594-fx044gcd	866	1	At	at	IN
cord-022594-fx044gcd	866	2	24	24	CD
cord-022594-fx044gcd	866	3	months	month	NNS
cord-022594-fx044gcd	866	4	,	,	,
cord-022594-fx044gcd	866	5	benefit	benefit	NN
cord-022594-fx044gcd	866	6	was	be	VBD
cord-022594-fx044gcd	866	7	reported	report	VBN
cord-022594-fx044gcd	866	8	in	in	IN
cord-022594-fx044gcd	866	9	all	all	DT
cord-022594-fx044gcd	866	10	five	five	CD
cord-022594-fx044gcd	866	11	components	component	NNS
cord-022594-fx044gcd	866	12	of	of	IN
cord-022594-fx044gcd	866	13	the	the	DT
cord-022594-fx044gcd	866	14	composite	composite	JJ
cord-022594-fx044gcd	866	15	measure	measure	NN
cord-022594-fx044gcd	866	16	for	for	IN
cord-022594-fx044gcd	866	17	both	both	DT
cord-022594-fx044gcd	866	18	active	active	JJ
cord-022594-fx044gcd	866	19	treatment	treatment	NN
cord-022594-fx044gcd	866	20	arms	arm	NNS
cord-022594-fx044gcd	866	21	,	,	,
cord-022594-fx044gcd	866	22	with	with	IN
cord-022594-fx044gcd	866	23	the	the	DT
cord-022594-fx044gcd	866	24	overall	overall	JJ
cord-022594-fx044gcd	866	25	greatest	great	JJS
cord-022594-fx044gcd	866	26	benefit	benefit	NN
cord-022594-fx044gcd	866	27	noted	note	VBN
cord-022594-fx044gcd	866	28	between	between	IN
cord-022594-fx044gcd	866	29	placebo	placebo	NN
cord-022594-fx044gcd	866	30	and	and	CC
cord-022594-fx044gcd	866	31	the	the	DT
cord-022594-fx044gcd	866	32	group	group	NN
cord-022594-fx044gcd	866	33	receiving	receive	VBG
cord-022594-fx044gcd	866	34	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	866	35	at	at	IN
cord-022594-fx044gcd	866	36	a	a	DT
cord-022594-fx044gcd	866	37	dose	dose	NN
cord-022594-fx044gcd	866	38	of	of	IN
cord-022594-fx044gcd	866	39	12	12	CD
cord-022594-fx044gcd	866	40	mg	mg	NNP
cord-022594-fx044gcd	866	41	/	/	SYM
cord-022594-fx044gcd	866	42	m	m	NN
cord-022594-fx044gcd	866	43	2	2	CD
cord-022594-fx044gcd	866	44	.	.	.
cord-022594-fx044gcd	867	1	The	the	DT
cord-022594-fx044gcd	867	2	magnitude	magnitude	NN
cord-022594-fx044gcd	867	3	of	of	IN
cord-022594-fx044gcd	867	4	the	the	DT
cord-022594-fx044gcd	867	5	effect	effect	NN
cord-022594-fx044gcd	867	6	on	on	IN
cord-022594-fx044gcd	867	7	EDSS	EDSS	NNP
cord-022594-fx044gcd	867	8	was	be	VBD
cord-022594-fx044gcd	867	9	rather	rather	RB
cord-022594-fx044gcd	867	10	modest	modest	JJ
cord-022594-fx044gcd	867	11	(	(	-LRB-
cord-022594-fx044gcd	867	12	mean	mean	VB
cord-022594-fx044gcd	867	13	EDSS	EDSS	NNP
cord-022594-fx044gcd	867	14	change	change	NN
cord-022594-fx044gcd	867	15	for	for	IN
cord-022594-fx044gcd	867	16	high	high	JJ
cord-022594-fx044gcd	867	17	-	-	HYPH
cord-022594-fx044gcd	867	18	dose	dose	NN
cord-022594-fx044gcd	867	19	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	867	20	,	,	,
cord-022594-fx044gcd	868	1	-0.13	-0.13	NFP
cord-022594-fx044gcd	869	1	[	[	-LRB-
cord-022594-fx044gcd	869	2	SD	SD	NNP
cord-022594-fx044gcd	869	3	0.90	0.90	CD
cord-022594-fx044gcd	869	4	]	]	-RRB-
cord-022594-fx044gcd	869	5	versus	versus	FW
cord-022594-fx044gcd	869	6	þ0.23	þ0.23	NNP
cord-022594-fx044gcd	869	7	[	[	-LRB-
cord-022594-fx044gcd	869	8	SD	SD	NNP
cord-022594-fx044gcd	869	9	1.01	1.01	CD
cord-022594-fx044gcd	869	10	]	]	-RRB-
cord-022594-fx044gcd	869	11	in	in	IN
cord-022594-fx044gcd	869	12	the	the	DT
cord-022594-fx044gcd	869	13	placebo	placebo	NN
cord-022594-fx044gcd	869	14	group	group	NN
cord-022594-fx044gcd	869	15	)	)	-RRB-
cord-022594-fx044gcd	869	16	.	.	.
cord-022594-fx044gcd	870	1	The	the	DT
cord-022594-fx044gcd	870	2	MRI	MRI	NNP
cord-022594-fx044gcd	870	3	results	result	NNS
cord-022594-fx044gcd	870	4	of	of	IN
cord-022594-fx044gcd	870	5	the	the	DT
cord-022594-fx044gcd	870	6	MIMS	MIMS	NNP
cord-022594-fx044gcd	870	7	trial	trial	NN
cord-022594-fx044gcd	870	8	were	be	VBD
cord-022594-fx044gcd	870	9	published	publish	VBN
cord-022594-fx044gcd	870	10	in	in	IN
cord-022594-fx044gcd	870	11	2005	2005	CD
cord-022594-fx044gcd	870	12	and	and	CC
cord-022594-fx044gcd	870	13	are	be	VBP
cord-022594-fx044gcd	870	14	frankly	frankly	RB
cord-022594-fx044gcd	870	15	disappointing	disappointing	JJ
cord-022594-fx044gcd	870	16	.	.	.
cord-022594-fx044gcd	871	1	99	99	CD
cord-022594-fx044gcd	872	1	In	in	IN
cord-022594-fx044gcd	872	2	a	a	DT
cord-022594-fx044gcd	872	3	subset	subset	NN
cord-022594-fx044gcd	872	4	of	of	IN
cord-022594-fx044gcd	872	5	110	110	CD
cord-022594-fx044gcd	872	6	patients	patient	NNS
cord-022594-fx044gcd	872	7	(	(	-LRB-
cord-022594-fx044gcd	872	8	out	out	IN
cord-022594-fx044gcd	872	9	of	of	IN
cord-022594-fx044gcd	872	10	194	194	CD
cord-022594-fx044gcd	872	11	in	in	IN
cord-022594-fx044gcd	872	12	the	the	DT
cord-022594-fx044gcd	872	13	trial	trial	NN
cord-022594-fx044gcd	872	14	overall	overall	RB
cord-022594-fx044gcd	872	15	)	)	-RRB-
cord-022594-fx044gcd	872	16	,	,	,
cord-022594-fx044gcd	872	17	the	the	DT
cord-022594-fx044gcd	872	18	12	12	CD
cord-022594-fx044gcd	872	19	mg	mg	NNP
cord-022594-fx044gcd	872	20	/	/	SYM
cord-022594-fx044gcd	872	21	m	m	NN
cord-022594-fx044gcd	872	22	2	2	CD
cord-022594-fx044gcd	872	23	dose	dose	NN
cord-022594-fx044gcd	872	24	failed	fail	VBD
cord-022594-fx044gcd	872	25	to	to	TO
cord-022594-fx044gcd	872	26	reach	reach	VB
cord-022594-fx044gcd	872	27	a	a	DT
cord-022594-fx044gcd	872	28	significant	significant	JJ
cord-022594-fx044gcd	872	29	difference	difference	NN
cord-022594-fx044gcd	872	30	from	from	IN
cord-022594-fx044gcd	872	31	placebo	placebo	NN
cord-022594-fx044gcd	872	32	as	as	IN
cord-022594-fx044gcd	872	33	measured	measure	VBN
cord-022594-fx044gcd	872	34	by	by	IN
cord-022594-fx044gcd	872	35	the	the	DT
cord-022594-fx044gcd	872	36	primary	primary	JJ
cord-022594-fx044gcd	872	37	MRI	MRI	NNP
cord-022594-fx044gcd	872	38	outcome	outcome	NN
cord-022594-fx044gcd	872	39	(	(	-LRB-
cord-022594-fx044gcd	872	40	total	total	JJ
cord-022594-fx044gcd	872	41	number	number	NN
cord-022594-fx044gcd	872	42	of	of	IN
cord-022594-fx044gcd	872	43	scans	scan	NNS
cord-022594-fx044gcd	872	44	with	with	IN
cord-022594-fx044gcd	872	45	gadoliniumenhancing	gadoliniumenhancing	NN
cord-022594-fx044gcd	872	46	lesions	lesion	NNS
cord-022594-fx044gcd	872	47	)	)	-RRB-
cord-022594-fx044gcd	872	48	.	.	.
cord-022594-fx044gcd	873	1	The	the	DT
cord-022594-fx044gcd	873	2	12	12	CD
cord-022594-fx044gcd	873	3	mg	mg	NNP
cord-022594-fx044gcd	873	4	/	/	SYM
cord-022594-fx044gcd	873	5	m	m	NN
cord-022594-fx044gcd	873	6	2	2	CD
cord-022594-fx044gcd	873	7	dose	dose	NN
cord-022594-fx044gcd	873	8	reduced	reduce	VBD
cord-022594-fx044gcd	873	9	the	the	DT
cord-022594-fx044gcd	873	10	number	number	NN
cord-022594-fx044gcd	873	11	of	of	IN
cord-022594-fx044gcd	873	12	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	873	13	lesions	lesion	NNS
cord-022594-fx044gcd	873	14	at	at	IN
cord-022594-fx044gcd	873	15	month	month	NN
cord-022594-fx044gcd	873	16	24	24	CD
cord-022594-fx044gcd	873	17	(	(	-LRB-
cord-022594-fx044gcd	873	18	p	p	NN
cord-022594-fx044gcd	873	19	¼	¼	NNP
cord-022594-fx044gcd	873	20	0.027	0.027	CD
cord-022594-fx044gcd	873	21	)	)	-RRB-
cord-022594-fx044gcd	873	22	and	and	CC
cord-022594-fx044gcd	873	23	showed	show	VBD
cord-022594-fx044gcd	873	24	a	a	DT
cord-022594-fx044gcd	873	25	trend	trend	NN
cord-022594-fx044gcd	873	26	at	at	IN
cord-022594-fx044gcd	873	27	month	month	NN
cord-022594-fx044gcd	873	28	12	12	CD
cord-022594-fx044gcd	873	29	(	(	-LRB-
cord-022594-fx044gcd	873	30	p	p	NN
cord-022594-fx044gcd	873	31	¼	¼	NN
cord-022594-fx044gcd	873	32	0.069	0.069	CD
cord-022594-fx044gcd	873	33	)	)	-RRB-
cord-022594-fx044gcd	873	34	.	.	.
cord-022594-fx044gcd	874	1	The	the	DT
cord-022594-fx044gcd	874	2	number	number	NN
cord-022594-fx044gcd	874	3	of	of	IN
cord-022594-fx044gcd	874	4	active	active	JJ
cord-022594-fx044gcd	874	5	MR	MR	NNP
cord-022594-fx044gcd	874	6	lesions	lesion	NNS
cord-022594-fx044gcd	874	7	showed	show	VBD
cord-022594-fx044gcd	874	8	a	a	DT
cord-022594-fx044gcd	874	9	trend	trend	NN
cord-022594-fx044gcd	874	10	toward	toward	IN
cord-022594-fx044gcd	874	11	reduction	reduction	NN
cord-022594-fx044gcd	874	12	in	in	IN
cord-022594-fx044gcd	874	13	the	the	DT
cord-022594-fx044gcd	874	14	12	12	CD
cord-022594-fx044gcd	874	15	mg	mg	NNP
cord-022594-fx044gcd	874	16	/	/	SYM
cord-022594-fx044gcd	874	17	m	m	NNP
cord-022594-fx044gcd	874	18	2	2	CD
cord-022594-fx044gcd	874	19	group	group	NN
cord-022594-fx044gcd	874	20	only	only	RB
cord-022594-fx044gcd	874	21	at	at	IN
cord-022594-fx044gcd	874	22	month	month	NN
cord-022594-fx044gcd	874	23	24	24	CD
cord-022594-fx044gcd	874	24	(	(	-LRB-
cord-022594-fx044gcd	874	25	p	p	NN
cord-022594-fx044gcd	874	26	¼	¼	NNP
cord-022594-fx044gcd	874	27	0.054	0.054	CD
cord-022594-fx044gcd	874	28	)	)	-RRB-
cord-022594-fx044gcd	874	29	.	.	.
cord-022594-fx044gcd	875	1	Overall	overall	RB
cord-022594-fx044gcd	875	2	,	,	,
cord-022594-fx044gcd	875	3	the	the	DT
cord-022594-fx044gcd	875	4	limited	limited	JJ
cord-022594-fx044gcd	875	5	evidence	evidence	NN
cord-022594-fx044gcd	875	6	to	to	IN
cord-022594-fx044gcd	875	7	date	date	NN
cord-022594-fx044gcd	875	8	supports	support	VBZ
cord-022594-fx044gcd	875	9	the	the	DT
cord-022594-fx044gcd	875	10	conclusion	conclusion	NN
cord-022594-fx044gcd	875	11	that	that	IN
cord-022594-fx044gcd	875	12	mitoxantrone	mitoxantrone	NNP
cord-022594-fx044gcd	875	13	reduces	reduce	VBZ
cord-022594-fx044gcd	875	14	relapse	relapse	NN
cord-022594-fx044gcd	875	15	frequency	frequency	NN
cord-022594-fx044gcd	875	16	and	and	CC
cord-022594-fx044gcd	875	17	MRI	MRI	NNP
cord-022594-fx044gcd	875	18	evidence	evidence	NN
cord-022594-fx044gcd	875	19	for	for	IN
cord-022594-fx044gcd	875	20	blood	blood	NN
cord-022594-fx044gcd	875	21	-	-	HYPH
cord-022594-fx044gcd	875	22	brain	brain	NN
cord-022594-fx044gcd	875	23	barrier	barrier	NN
cord-022594-fx044gcd	875	24	disruption	disruption	NN
cord-022594-fx044gcd	875	25	in	in	IN
cord-022594-fx044gcd	875	26	patients	patient	NNS
cord-022594-fx044gcd	875	27	with	with	IN
cord-022594-fx044gcd	875	28	very	very	RB
cord-022594-fx044gcd	875	29	active	active	JJ
cord-022594-fx044gcd	875	30	MS	MS	NNP
cord-022594-fx044gcd	875	31	.	.	.
cord-022594-fx044gcd	876	1	The	the	DT
cord-022594-fx044gcd	876	2	benefit	benefit	NN
cord-022594-fx044gcd	876	3	for	for	IN
cord-022594-fx044gcd	876	4	patients	patient	NNS
cord-022594-fx044gcd	876	5	with	with	IN
cord-022594-fx044gcd	876	6	relapse	relapse	NN
cord-022594-fx044gcd	876	7	-	-	HYPH
cord-022594-fx044gcd	876	8	independent	independent	JJ
cord-022594-fx044gcd	876	9	progression	progression	NN
cord-022594-fx044gcd	876	10	is	be	VBZ
cord-022594-fx044gcd	876	11	uncertain	uncertain	JJ
cord-022594-fx044gcd	876	12	at	at	IN
cord-022594-fx044gcd	876	13	best	good	JJS
cord-022594-fx044gcd	876	14	.	.	.
cord-022594-fx044gcd	877	1	From	from	IN
cord-022594-fx044gcd	877	2	the	the	DT
cord-022594-fx044gcd	877	3	MIMS	MIMS	NNP
cord-022594-fx044gcd	877	4	results	result	NNS
cord-022594-fx044gcd	877	5	,	,	,
cord-022594-fx044gcd	877	6	one	one	PRP
cord-022594-fx044gcd	877	7	would	would	MD
cord-022594-fx044gcd	877	8	need	need	VB
cord-022594-fx044gcd	877	9	to	to	TO
cord-022594-fx044gcd	877	10	treat	treat	VB
cord-022594-fx044gcd	877	11	11	11	CD
cord-022594-fx044gcd	877	12	patients	patient	NNS
cord-022594-fx044gcd	877	13	with	with	IN
cord-022594-fx044gcd	877	14	secondary	secondary	JJ
cord-022594-fx044gcd	877	15	progressive	progressive	JJ
cord-022594-fx044gcd	877	16	multiple	multiple	JJ
cord-022594-fx044gcd	877	17	sclerosis	sclerosis	NN
cord-022594-fx044gcd	877	18	for	for	IN
cord-022594-fx044gcd	877	19	2	2	CD
cord-022594-fx044gcd	877	20	years	year	NNS
cord-022594-fx044gcd	877	21	to	to	TO
cord-022594-fx044gcd	877	22	prevent	prevent	VB
cord-022594-fx044gcd	877	23	one	one	CD
cord-022594-fx044gcd	877	24	person	person	NN
cord-022594-fx044gcd	877	25	from	from	IN
cord-022594-fx044gcd	877	26	worsening	worsen	VBG
cord-022594-fx044gcd	877	27	by	by	IN
cord-022594-fx044gcd	877	28	1.0	1.0	CD
cord-022594-fx044gcd	877	29	EDSS	EDSS	NNP
cord-022594-fx044gcd	877	30	point	point	NN
cord-022594-fx044gcd	877	31	.	.	.
cord-022594-fx044gcd	878	1	This	this	DT
cord-022594-fx044gcd	878	2	modest	modest	JJ
cord-022594-fx044gcd	878	3	benefit	benefit	NN
cord-022594-fx044gcd	878	4	must	must	MD
cord-022594-fx044gcd	878	5	be	be	VB
cord-022594-fx044gcd	878	6	carefully	carefully	RB
cord-022594-fx044gcd	878	7	examined	examine	VBN
cord-022594-fx044gcd	878	8	in	in	IN
cord-022594-fx044gcd	878	9	light	light	NN
cord-022594-fx044gcd	878	10	of	of	IN
cord-022594-fx044gcd	878	11	the	the	DT
cord-022594-fx044gcd	878	12	significant	significant	JJ
cord-022594-fx044gcd	878	13	risk	risk	NN
cord-022594-fx044gcd	878	14	for	for	IN
cord-022594-fx044gcd	878	15	toxicity	toxicity	NN
cord-022594-fx044gcd	878	16	.	.	.
cord-022594-fx044gcd	879	1	Therapy	therapy	NN
cord-022594-fx044gcd	879	2	of	of	IN
cord-022594-fx044gcd	879	3	PPMS	PPMS	NNP
cord-022594-fx044gcd	879	4	.	.	.
cord-022594-fx044gcd	880	1	Unfortunately	unfortunately	RB
cord-022594-fx044gcd	880	2	,	,	,
cord-022594-fx044gcd	880	3	for	for	IN
cord-022594-fx044gcd	880	4	classical	classical	JJ
cord-022594-fx044gcd	880	5	PPMS	PPMS	NNP
cord-022594-fx044gcd	880	6	cases	case	NNS
cord-022594-fx044gcd	880	7	that	that	WDT
cord-022594-fx044gcd	880	8	present	present	VBP
cord-022594-fx044gcd	880	9	with	with	IN
cord-022594-fx044gcd	880	10	insidious	insidious	JJ
cord-022594-fx044gcd	880	11	progression	progression	NN
cord-022594-fx044gcd	880	12	of	of	IN
cord-022594-fx044gcd	880	13	usually	usually	RB
cord-022594-fx044gcd	880	14	myelopathy	myelopathy	VBN
cord-022594-fx044gcd	880	15	symptoms	symptom	NNS
cord-022594-fx044gcd	880	16	,	,	,
cord-022594-fx044gcd	880	17	none	none	NN
cord-022594-fx044gcd	880	18	of	of	IN
cord-022594-fx044gcd	880	19	the	the	DT
cord-022594-fx044gcd	880	20	currently	currently	RB
cord-022594-fx044gcd	880	21	available	available	JJ
cord-022594-fx044gcd	880	22	treatments	treatment	NNS
cord-022594-fx044gcd	880	23	offer	offer	VBP
cord-022594-fx044gcd	880	24	any	any	DT
cord-022594-fx044gcd	880	25	clear	clear	JJ
cord-022594-fx044gcd	880	26	benefit	benefit	NN
cord-022594-fx044gcd	880	27	.	.	.
cord-022594-fx044gcd	881	1	The	the	DT
cord-022594-fx044gcd	881	2	PROMISE	PROMISE	NNP
cord-022594-fx044gcd	881	3	trial	trial	NN
cord-022594-fx044gcd	881	4	,	,	,
cord-022594-fx044gcd	881	5	in	in	IN
cord-022594-fx044gcd	881	6	which	which	WDT
cord-022594-fx044gcd	881	7	over	over	IN
cord-022594-fx044gcd	881	8	900	900	CD
cord-022594-fx044gcd	881	9	PPMS	PPMS	NNP
cord-022594-fx044gcd	881	10	patients	patient	NNS
cord-022594-fx044gcd	881	11	were	be	VBD
cord-022594-fx044gcd	881	12	treated	treat	VBN
cord-022594-fx044gcd	881	13	with	with	IN
cord-022594-fx044gcd	881	14	GA	GA	NNP
cord-022594-fx044gcd	881	15	,	,	,
cord-022594-fx044gcd	881	16	was	be	VBD
cord-022594-fx044gcd	881	17	terminated	terminate	VBN
cord-022594-fx044gcd	881	18	early	early	RB
cord-022594-fx044gcd	881	19	owing	owe	VBG
cord-022594-fx044gcd	881	20	to	to	IN
cord-022594-fx044gcd	881	21	lack	lack	NN
cord-022594-fx044gcd	881	22	of	of	IN
cord-022594-fx044gcd	881	23	effectiveness	effectiveness	NN
cord-022594-fx044gcd	881	24	.	.	.
cord-022594-fx044gcd	882	1	The	the	DT
cord-022594-fx044gcd	882	2	results	result	NNS
cord-022594-fx044gcd	882	3	of	of	IN
cord-022594-fx044gcd	882	4	this	this	DT
cord-022594-fx044gcd	882	5	trial	trial	NN
cord-022594-fx044gcd	882	6	have	have	VBP
cord-022594-fx044gcd	882	7	not	not	RB
cord-022594-fx044gcd	882	8	yet	yet	RB
cord-022594-fx044gcd	882	9	been	be	VBN
cord-022594-fx044gcd	882	10	published	publish	VBN
cord-022594-fx044gcd	882	11	.	.	.
cord-022594-fx044gcd	883	1	A	a	DT
cord-022594-fx044gcd	883	2	small	small	JJ
cord-022594-fx044gcd	883	3	study	study	NN
cord-022594-fx044gcd	883	4	with	with	IN
cord-022594-fx044gcd	883	5	intramuscular	intramuscular	JJ
cord-022594-fx044gcd	883	6	interferon	interferon	NN
cord-022594-fx044gcd	883	7	-	-	HYPH
cord-022594-fx044gcd	883	8	b	b	NN
cord-022594-fx044gcd	883	9	1a	1a	NN
cord-022594-fx044gcd	883	10	was	be	VBD
cord-022594-fx044gcd	883	11	also	also	RB
cord-022594-fx044gcd	883	12	negative	negative	JJ
cord-022594-fx044gcd	883	13	.	.	.
cord-022594-fx044gcd	884	1	100	100	CD
cord-022594-fx044gcd	885	1	Currently	currently	RB
cord-022594-fx044gcd	885	2	a	a	DT
cord-022594-fx044gcd	885	3	large	large	JJ
cord-022594-fx044gcd	885	4	trial	trial	NN
cord-022594-fx044gcd	885	5	is	be	VBZ
cord-022594-fx044gcd	885	6	under	under	IN
cord-022594-fx044gcd	885	7	way	way	NN
cord-022594-fx044gcd	885	8	with	with	IN
cord-022594-fx044gcd	885	9	rituximab	rituximab	NN
cord-022594-fx044gcd	885	10	in	in	IN
cord-022594-fx044gcd	885	11	CSF	CSF	NNP
cord-022594-fx044gcd	885	12	OCB	OCB	NNP
cord-022594-fx044gcd	885	13	-	-	HYPH
cord-022594-fx044gcd	885	14	positive	positive	JJ
cord-022594-fx044gcd	885	15	PPMS	PPMS	NNP
cord-022594-fx044gcd	885	16	patients	patient	NNS
cord-022594-fx044gcd	885	17	.	.	.
cord-022594-fx044gcd	886	1	Until	until	IN
cord-022594-fx044gcd	886	2	we	-PRON-	PRP
cord-022594-fx044gcd	886	3	clearly	clearly	RB
cord-022594-fx044gcd	886	4	understand	understand	VBP
cord-022594-fx044gcd	886	5	the	the	DT
cord-022594-fx044gcd	886	6	pathophysiology	pathophysiology	NN
cord-022594-fx044gcd	886	7	of	of	IN
cord-022594-fx044gcd	886	8	slow	slow	JJ
cord-022594-fx044gcd	886	9	progression	progression	NN
cord-022594-fx044gcd	886	10	in	in	IN
cord-022594-fx044gcd	886	11	MS	MS	NNP
cord-022594-fx044gcd	886	12	,	,	,
cord-022594-fx044gcd	886	13	it	-PRON-	PRP
cord-022594-fx044gcd	886	14	is	be	VBZ
cord-022594-fx044gcd	886	15	unlikely	unlikely	JJ
cord-022594-fx044gcd	886	16	that	that	IN
cord-022594-fx044gcd	886	17	we	-PRON-	PRP
cord-022594-fx044gcd	886	18	will	will	MD
cord-022594-fx044gcd	886	19	find	find	VB
cord-022594-fx044gcd	886	20	a	a	DT
cord-022594-fx044gcd	886	21	treatment	treatment	NN
cord-022594-fx044gcd	886	22	that	that	WDT
cord-022594-fx044gcd	886	23	has	have	VBZ
cord-022594-fx044gcd	886	24	an	an	DT
cord-022594-fx044gcd	886	25	important	important	JJ
cord-022594-fx044gcd	886	26	impact	impact	NN
cord-022594-fx044gcd	886	27	on	on	IN
cord-022594-fx044gcd	886	28	this	this	DT
cord-022594-fx044gcd	886	29	form	form	NN
cord-022594-fx044gcd	886	30	of	of	IN
cord-022594-fx044gcd	886	31	MS	MS	NNP
cord-022594-fx044gcd	886	32	.	.	.
cord-022594-fx044gcd	887	1	Symptomatic	symptomatic	JJ
cord-022594-fx044gcd	887	2	treatment	treatment	NN
cord-022594-fx044gcd	887	3	modalities	modality	NNS
cord-022594-fx044gcd	887	4	,	,	,
cord-022594-fx044gcd	887	5	including	include	VBG
cord-022594-fx044gcd	887	6	physical	physical	JJ
cord-022594-fx044gcd	887	7	and	and	CC
cord-022594-fx044gcd	887	8	occupational	occupational	JJ
cord-022594-fx044gcd	887	9	therapy	therapy	NN
cord-022594-fx044gcd	887	10	,	,	,
cord-022594-fx044gcd	887	11	are	be	VBP
cord-022594-fx044gcd	887	12	very	very	RB
cord-022594-fx044gcd	887	13	important	important	JJ
cord-022594-fx044gcd	887	14	,	,	,
cord-022594-fx044gcd	887	15	yet	yet	CC
cord-022594-fx044gcd	887	16	frequently	frequently	RB
cord-022594-fx044gcd	887	17	overlooked	overlook	VBN
cord-022594-fx044gcd	887	18	in	in	IN
cord-022594-fx044gcd	887	19	this	this	DT
cord-022594-fx044gcd	887	20	patient	patient	JJ
cord-022594-fx044gcd	887	21	population	population	NN
cord-022594-fx044gcd	887	22	.	.	.
cord-022594-fx044gcd	888	1	Other	other	JJ
cord-022594-fx044gcd	888	2	Immunomodulator	Immunomodulator	NNP
cord-022594-fx044gcd	888	3	Therapies	Therapies	NNPS
cord-022594-fx044gcd	888	4	.	.	.
cord-022594-fx044gcd	889	1	Cyclophosphamide	Cyclophosphamide	NNP
cord-022594-fx044gcd	889	2	is	be	VBZ
cord-022594-fx044gcd	889	3	an	an	DT
cord-022594-fx044gcd	889	4	alkylating	alkylating	JJ
cord-022594-fx044gcd	889	5	agent	agent	NN
cord-022594-fx044gcd	889	6	that	that	WDT
cord-022594-fx044gcd	889	7	has	have	VBZ
cord-022594-fx044gcd	889	8	indiscriminate	indiscriminate	JJ
cord-022594-fx044gcd	889	9	cytotoxic	cytotoxic	JJ
cord-022594-fx044gcd	889	10	effects	effect	NNS
cord-022594-fx044gcd	889	11	on	on	IN
cord-022594-fx044gcd	889	12	rapidly	rapidly	RB
cord-022594-fx044gcd	889	13	dividing	divide	VBG
cord-022594-fx044gcd	889	14	cells	cell	NNS
cord-022594-fx044gcd	889	15	,	,	,
cord-022594-fx044gcd	889	16	including	include	VBG
cord-022594-fx044gcd	889	17	lymphocytes	lymphocyte	NNS
cord-022594-fx044gcd	889	18	,	,	,
cord-022594-fx044gcd	889	19	making	make	VBG
cord-022594-fx044gcd	889	20	it	-PRON-	PRP
cord-022594-fx044gcd	889	21	a	a	DT
cord-022594-fx044gcd	889	22	potent	potent	JJ
cord-022594-fx044gcd	889	23	immunosuppressant	immunosuppressant	NN
cord-022594-fx044gcd	889	24	.	.	.
cord-022594-fx044gcd	890	1	Several	several	JJ
cord-022594-fx044gcd	890	2	studies	study	NNS
cord-022594-fx044gcd	890	3	have	have	VBP
cord-022594-fx044gcd	890	4	claimed	claim	VBN
cord-022594-fx044gcd	890	5	a	a	DT
cord-022594-fx044gcd	890	6	beneficial	beneficial	JJ
cord-022594-fx044gcd	890	7	effect	effect	NN
cord-022594-fx044gcd	890	8	in	in	IN
cord-022594-fx044gcd	890	9	both	both	DT
cord-022594-fx044gcd	890	10	relapsing	relapsing	JJ
cord-022594-fx044gcd	890	11	and	and	CC
cord-022594-fx044gcd	890	12	progressive	progressive	JJ
cord-022594-fx044gcd	890	13	patients	patient	NNS
cord-022594-fx044gcd	890	14	.	.	.
cord-022594-fx044gcd	891	1	Because	because	IN
cord-022594-fx044gcd	891	2	one	one	CD
cord-022594-fx044gcd	891	3	of	of	IN
cord-022594-fx044gcd	891	4	the	the	DT
cord-022594-fx044gcd	891	5	major	major	JJ
cord-022594-fx044gcd	891	6	studies	study	NNS
cord-022594-fx044gcd	891	7	included	include	VBD
cord-022594-fx044gcd	891	8	ACTH	ACTH	NNP
cord-022594-fx044gcd	891	9	,	,	,
cord-022594-fx044gcd	891	10	IV	IV	NNP
cord-022594-fx044gcd	891	11	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	891	12	is	be	VBZ
cord-022594-fx044gcd	891	13	sometimes	sometimes	RB
cord-022594-fx044gcd	891	14	given	give	VBN
cord-022594-fx044gcd	891	15	with	with	IN
cord-022594-fx044gcd	891	16	the	the	DT
cord-022594-fx044gcd	891	17	cyclophosphamide	cyclophosphamide	NN
cord-022594-fx044gcd	891	18	.	.	.
cord-022594-fx044gcd	892	1	Other	other	JJ
cord-022594-fx044gcd	892	2	trials	trial	NNS
cord-022594-fx044gcd	892	3	have	have	VBP
cord-022594-fx044gcd	892	4	not	not	RB
cord-022594-fx044gcd	892	5	found	find	VBN
cord-022594-fx044gcd	892	6	a	a	DT
cord-022594-fx044gcd	892	7	favorable	favorable	JJ
cord-022594-fx044gcd	892	8	effect	effect	NN
cord-022594-fx044gcd	892	9	.	.	.
cord-022594-fx044gcd	893	1	Because	because	IN
cord-022594-fx044gcd	893	2	of	of	IN
cord-022594-fx044gcd	893	3	the	the	DT
cord-022594-fx044gcd	893	4	inconsistent	inconsistent	JJ
cord-022594-fx044gcd	893	5	results	result	NNS
cord-022594-fx044gcd	893	6	,	,	,
cord-022594-fx044gcd	893	7	high	high	JJ
cord-022594-fx044gcd	893	8	potential	potential	NN
cord-022594-fx044gcd	893	9	for	for	IN
cord-022594-fx044gcd	893	10	serious	serious	JJ
cord-022594-fx044gcd	893	11	side	side	NN
cord-022594-fx044gcd	893	12	effects	effect	NNS
cord-022594-fx044gcd	893	13	,	,	,
cord-022594-fx044gcd	893	14	and	and	CC
cord-022594-fx044gcd	893	15	adverse	adverse	JJ
cord-022594-fx044gcd	893	16	reactions	reaction	NNS
cord-022594-fx044gcd	893	17	,	,	,
cord-022594-fx044gcd	893	18	including	include	VBG
cord-022594-fx044gcd	893	19	hemorrhagic	hemorrhagic	JJ
cord-022594-fx044gcd	893	20	cystitis	cystitis	NN
cord-022594-fx044gcd	893	21	and	and	CC
cord-022594-fx044gcd	893	22	malignancy	malignancy	NN
cord-022594-fx044gcd	893	23	,	,	,
cord-022594-fx044gcd	893	24	cyclophosphamide	cyclophosphamide	RB
cord-022594-fx044gcd	893	25	is	be	VBZ
cord-022594-fx044gcd	893	26	not	not	RB
cord-022594-fx044gcd	893	27	widely	widely	RB
cord-022594-fx044gcd	893	28	used	use	VBN
cord-022594-fx044gcd	893	29	.	.	.
cord-022594-fx044gcd	894	1	Some	some	DT
cord-022594-fx044gcd	894	2	centers	center	NNS
cord-022594-fx044gcd	894	3	,	,	,
cord-022594-fx044gcd	894	4	however	however	RB
cord-022594-fx044gcd	894	5	,	,	,
cord-022594-fx044gcd	894	6	use	use	VBP
cord-022594-fx044gcd	894	7	cyclophosphamide	cyclophosphamide	NN
cord-022594-fx044gcd	894	8	in	in	IN
cord-022594-fx044gcd	894	9	patients	patient	NNS
cord-022594-fx044gcd	894	10	with	with	IN
cord-022594-fx044gcd	894	11	aggressive	aggressive	JJ
cord-022594-fx044gcd	894	12	disease	disease	NN
cord-022594-fx044gcd	894	13	in	in	IN
cord-022594-fx044gcd	894	14	whom	whom	WP
cord-022594-fx044gcd	894	15	more	more	RBR
cord-022594-fx044gcd	894	16	conventional	conventional	JJ
cord-022594-fx044gcd	894	17	treatments	treatment	NNS
cord-022594-fx044gcd	894	18	have	have	VBP
cord-022594-fx044gcd	894	19	failed	fail	VBN
cord-022594-fx044gcd	894	20	.	.	.
cord-022594-fx044gcd	895	1	Azathioprine	Azathioprine	NNP
cord-022594-fx044gcd	895	2	,	,	,
cord-022594-fx044gcd	895	3	a	a	DT
cord-022594-fx044gcd	895	4	purine	purine	NN
cord-022594-fx044gcd	895	5	analog	analog	NN
cord-022594-fx044gcd	895	6	antimetabolite	antimetabolite	NNP
cord-022594-fx044gcd	895	7	,	,	,
cord-022594-fx044gcd	895	8	has	have	VBZ
cord-022594-fx044gcd	895	9	marginal	marginal	JJ
cord-022594-fx044gcd	895	10	efficacy	efficacy	NN
cord-022594-fx044gcd	895	11	in	in	IN
cord-022594-fx044gcd	895	12	the	the	DT
cord-022594-fx044gcd	895	13	treatment	treatment	NN
cord-022594-fx044gcd	895	14	of	of	IN
cord-022594-fx044gcd	895	15	MS	MS	NNP
cord-022594-fx044gcd	895	16	.	.	.
cord-022594-fx044gcd	896	1	A	a	DT
cord-022594-fx044gcd	896	2	meta	meta	JJ
cord-022594-fx044gcd	896	3	-	-	HYPH
cord-022594-fx044gcd	896	4	analysis	analysis	NN
cord-022594-fx044gcd	896	5	of	of	IN
cord-022594-fx044gcd	896	6	all	all	DT
cord-022594-fx044gcd	896	7	blinded	blind	VBN
cord-022594-fx044gcd	896	8	,	,	,
cord-022594-fx044gcd	896	9	placebo	placebo	NN
cord-022594-fx044gcd	896	10	-	-	HYPH
cord-022594-fx044gcd	896	11	controlled	control	VBN
cord-022594-fx044gcd	896	12	studies	study	NNS
cord-022594-fx044gcd	896	13	confirmed	confirm	VBD
cord-022594-fx044gcd	896	14	a	a	DT
cord-022594-fx044gcd	896	15	slight	slight	JJ
cord-022594-fx044gcd	896	16	benefit	benefit	NN
cord-022594-fx044gcd	896	17	of	of	IN
cord-022594-fx044gcd	896	18	slowed	slowed	JJ
cord-022594-fx044gcd	896	19	progression	progression	NN
cord-022594-fx044gcd	896	20	and	and	CC
cord-022594-fx044gcd	896	21	less	less	RBR
cord-022594-fx044gcd	896	22	frequent	frequent	JJ
cord-022594-fx044gcd	896	23	relapses	relapse	NNS
cord-022594-fx044gcd	896	24	.	.	.
cord-022594-fx044gcd	897	1	101	101	CD
cord-022594-fx044gcd	898	1	The	the	DT
cord-022594-fx044gcd	898	2	toxicity	toxicity	NN
cord-022594-fx044gcd	898	3	of	of	IN
cord-022594-fx044gcd	898	4	azathioprine	azathioprine	NN
cord-022594-fx044gcd	898	5	and	and	CC
cord-022594-fx044gcd	898	6	its	-PRON-	PRP$
cord-022594-fx044gcd	898	7	slow	slow	JJ
cord-022594-fx044gcd	898	8	onset	onset	NN
cord-022594-fx044gcd	898	9	of	of	IN
cord-022594-fx044gcd	898	10	action	action	NN
cord-022594-fx044gcd	898	11	have	have	VBP
cord-022594-fx044gcd	898	12	prevented	prevent	VBN
cord-022594-fx044gcd	898	13	its	-PRON-	PRP$
cord-022594-fx044gcd	898	14	widespread	widespread	JJ
cord-022594-fx044gcd	898	15	use	use	NN
cord-022594-fx044gcd	898	16	.	.	.
cord-022594-fx044gcd	899	1	Besides	besides	IN
cord-022594-fx044gcd	899	2	the	the	DT
cord-022594-fx044gcd	899	3	liver	liver	NN
cord-022594-fx044gcd	899	4	toxicity	toxicity	NN
cord-022594-fx044gcd	899	5	and	and	CC
cord-022594-fx044gcd	899	6	hematological	hematological	JJ
cord-022594-fx044gcd	899	7	effects	effect	NNS
cord-022594-fx044gcd	899	8	,	,	,
cord-022594-fx044gcd	899	9	the	the	DT
cord-022594-fx044gcd	899	10	induction	induction	NN
cord-022594-fx044gcd	899	11	of	of	IN
cord-022594-fx044gcd	899	12	malignancies	malignancy	NNS
cord-022594-fx044gcd	899	13	has	have	VBZ
cord-022594-fx044gcd	899	14	been	be	VBN
cord-022594-fx044gcd	899	15	a	a	DT
cord-022594-fx044gcd	899	16	concern	concern	NN
cord-022594-fx044gcd	899	17	.	.	.
cord-022594-fx044gcd	900	1	One	one	CD
cord-022594-fx044gcd	900	2	retrospective	retrospective	JJ
cord-022594-fx044gcd	900	3	study	study	NN
cord-022594-fx044gcd	900	4	did	do	VBD
cord-022594-fx044gcd	900	5	not	not	RB
cord-022594-fx044gcd	900	6	find	find	VB
cord-022594-fx044gcd	900	7	an	an	DT
cord-022594-fx044gcd	900	8	increased	increase	VBN
cord-022594-fx044gcd	900	9	incidence	incidence	NN
cord-022594-fx044gcd	900	10	of	of	IN
cord-022594-fx044gcd	900	11	cancer	cancer	NN
cord-022594-fx044gcd	900	12	in	in	IN
cord-022594-fx044gcd	900	13	MS	MS	NNP
cord-022594-fx044gcd	900	14	patients	patient	NNS
cord-022594-fx044gcd	900	15	treated	treat	VBN
cord-022594-fx044gcd	900	16	with	with	IN
cord-022594-fx044gcd	900	17	azathioprine	azathioprine	NN
cord-022594-fx044gcd	900	18	,	,	,
cord-022594-fx044gcd	900	19	but	but	CC
cord-022594-fx044gcd	900	20	this	this	DT
cord-022594-fx044gcd	900	21	remains	remain	VBZ
cord-022594-fx044gcd	900	22	a	a	DT
cord-022594-fx044gcd	900	23	potential	potential	JJ
cord-022594-fx044gcd	900	24	risk	risk	NN
cord-022594-fx044gcd	900	25	.	.	.
cord-022594-fx044gcd	901	1	Methotrexate	Methotrexate	NNP
cord-022594-fx044gcd	901	2	is	be	VBZ
cord-022594-fx044gcd	901	3	a	a	DT
cord-022594-fx044gcd	901	4	folate	folate	JJ
cord-022594-fx044gcd	901	5	antagonist	antagonist	NN
cord-022594-fx044gcd	901	6	that	that	WDT
cord-022594-fx044gcd	901	7	is	be	VBZ
cord-022594-fx044gcd	901	8	effective	effective	JJ
cord-022594-fx044gcd	901	9	in	in	IN
cord-022594-fx044gcd	901	10	rheumatoid	rheumatoid	JJ
cord-022594-fx044gcd	901	11	arthritis	arthritis	NN
cord-022594-fx044gcd	901	12	.	.	.
cord-022594-fx044gcd	902	1	Weekly	weekly	JJ
cord-022594-fx044gcd	902	2	low	low	JJ
cord-022594-fx044gcd	902	3	-	-	HYPH
cord-022594-fx044gcd	902	4	dose	dose	NN
cord-022594-fx044gcd	902	5	oral	oral	JJ
cord-022594-fx044gcd	902	6	methotrexate	methotrexate	NNP
cord-022594-fx044gcd	902	7	was	be	VBD
cord-022594-fx044gcd	902	8	found	find	VBN
cord-022594-fx044gcd	902	9	to	to	TO
cord-022594-fx044gcd	902	10	delay	delay	VB
cord-022594-fx044gcd	902	11	upper	upper	JJ
cord-022594-fx044gcd	902	12	extremity	extremity	NN
cord-022594-fx044gcd	902	13	dysfunction	dysfunction	NN
cord-022594-fx044gcd	902	14	in	in	IN
cord-022594-fx044gcd	902	15	SPMS	SPMS	NNP
cord-022594-fx044gcd	902	16	patients	patient	NNS
cord-022594-fx044gcd	902	17	,	,	,
cord-022594-fx044gcd	902	18	although	although	IN
cord-022594-fx044gcd	902	19	it	-PRON-	PRP
cord-022594-fx044gcd	902	20	had	have	VBD
cord-022594-fx044gcd	902	21	no	no	DT
cord-022594-fx044gcd	902	22	effect	effect	NN
cord-022594-fx044gcd	902	23	on	on	IN
cord-022594-fx044gcd	902	24	the	the	DT
cord-022594-fx044gcd	902	25	more	more	RBR
cord-022594-fx044gcd	902	26	traditional	traditional	JJ
cord-022594-fx044gcd	902	27	measures	measure	NNS
cord-022594-fx044gcd	902	28	of	of	IN
cord-022594-fx044gcd	902	29	disability	disability	NN
cord-022594-fx044gcd	902	30	,	,	,
cord-022594-fx044gcd	902	31	including	include	VBG
cord-022594-fx044gcd	902	32	the	the	DT
cord-022594-fx044gcd	902	33	Expanded	expand	VBN
cord-022594-fx044gcd	902	34	Disability	Disability	NNP
cord-022594-fx044gcd	902	35	Status	status	NN
cord-022594-fx044gcd	902	36	Scale	scale	NN
cord-022594-fx044gcd	902	37	(	(	-LRB-
cord-022594-fx044gcd	902	38	EDSS	EDSS	NNP
cord-022594-fx044gcd	902	39	)	)	-RRB-
cord-022594-fx044gcd	902	40	.	.	.
cord-022594-fx044gcd	903	1	102	102	CD
cord-022594-fx044gcd	904	1	The	the	DT
cord-022594-fx044gcd	904	2	use	use	NN
cord-022594-fx044gcd	904	3	of	of	IN
cord-022594-fx044gcd	904	4	cyclosporine	cyclosporine	NN
cord-022594-fx044gcd	904	5	in	in	IN
cord-022594-fx044gcd	904	6	the	the	DT
cord-022594-fx044gcd	904	7	treatment	treatment	NN
cord-022594-fx044gcd	904	8	of	of	IN
cord-022594-fx044gcd	904	9	MS	MS	NNP
cord-022594-fx044gcd	904	10	has	have	VBZ
cord-022594-fx044gcd	904	11	been	be	VBN
cord-022594-fx044gcd	904	12	evaluated	evaluate	VBN
cord-022594-fx044gcd	904	13	in	in	IN
cord-022594-fx044gcd	904	14	three	three	CD
cord-022594-fx044gcd	904	15	clinical	clinical	JJ
cord-022594-fx044gcd	904	16	trials	trial	NNS
cord-022594-fx044gcd	904	17	,	,	,
cord-022594-fx044gcd	904	18	none	none	NN
cord-022594-fx044gcd	904	19	of	of	IN
cord-022594-fx044gcd	904	20	which	which	WDT
cord-022594-fx044gcd	904	21	have	have	VBP
cord-022594-fx044gcd	904	22	demonstrated	demonstrate	VBN
cord-022594-fx044gcd	904	23	a	a	DT
cord-022594-fx044gcd	904	24	convincing	convincing	JJ
cord-022594-fx044gcd	904	25	benefit	benefit	NN
cord-022594-fx044gcd	904	26	.	.	.
cord-022594-fx044gcd	905	1	In	in	IN
cord-022594-fx044gcd	905	2	addition	addition	NN
cord-022594-fx044gcd	905	3	,	,	,
cord-022594-fx044gcd	905	4	side	side	NN
cord-022594-fx044gcd	905	5	effects	effect	NNS
cord-022594-fx044gcd	905	6	such	such	JJ
cord-022594-fx044gcd	905	7	as	as	IN
cord-022594-fx044gcd	905	8	hypertension	hypertension	NN
cord-022594-fx044gcd	905	9	and	and	CC
cord-022594-fx044gcd	905	10	elevation	elevation	NN
cord-022594-fx044gcd	905	11	of	of	IN
cord-022594-fx044gcd	905	12	creatinine	creatinine	NN
cord-022594-fx044gcd	905	13	were	be	VBD
cord-022594-fx044gcd	905	14	common	common	JJ
cord-022594-fx044gcd	905	15	.	.	.
cord-022594-fx044gcd	906	1	Numerous	numerous	JJ
cord-022594-fx044gcd	906	2	additional	additional	JJ
cord-022594-fx044gcd	906	3	therapies	therapy	NNS
cord-022594-fx044gcd	906	4	have	have	VBP
cord-022594-fx044gcd	906	5	been	be	VBN
cord-022594-fx044gcd	906	6	tested	test	VBN
cord-022594-fx044gcd	906	7	,	,	,
cord-022594-fx044gcd	906	8	and	and	CC
cord-022594-fx044gcd	906	9	many	many	JJ
cord-022594-fx044gcd	906	10	others	other	NNS
cord-022594-fx044gcd	906	11	are	be	VBP
cord-022594-fx044gcd	906	12	undergoing	undergo	VBG
cord-022594-fx044gcd	906	13	evaluation	evaluation	NN
cord-022594-fx044gcd	906	14	.	.	.
cord-022594-fx044gcd	907	1	The	the	DT
cord-022594-fx044gcd	907	2	antiherpesvirus	antiherpesvirus	NNP
cord-022594-fx044gcd	907	3	drug	drug	NN
cord-022594-fx044gcd	907	4	acyclovir	acyclovir	NNP
cord-022594-fx044gcd	907	5	has	have	VBZ
cord-022594-fx044gcd	907	6	been	be	VBN
cord-022594-fx044gcd	907	7	shown	show	VBN
cord-022594-fx044gcd	907	8	to	to	TO
cord-022594-fx044gcd	907	9	reduce	reduce	VB
cord-022594-fx044gcd	907	10	relapse	relapse	NN
cord-022594-fx044gcd	907	11	frequency	frequency	NN
cord-022594-fx044gcd	907	12	in	in	IN
cord-022594-fx044gcd	907	13	a	a	DT
cord-022594-fx044gcd	907	14	small	small	JJ
cord-022594-fx044gcd	907	15	prospective	prospective	JJ
cord-022594-fx044gcd	907	16	trial	trial	NN
cord-022594-fx044gcd	907	17	.	.	.
cord-022594-fx044gcd	908	1	Total	total	JJ
cord-022594-fx044gcd	908	2	lymphoid	lymphoid	JJ
cord-022594-fx044gcd	908	3	irradiation	irradiation	NN
cord-022594-fx044gcd	908	4	was	be	VBD
cord-022594-fx044gcd	908	5	found	find	VBN
cord-022594-fx044gcd	908	6	to	to	TO
cord-022594-fx044gcd	908	7	slow	slow	VB
cord-022594-fx044gcd	908	8	the	the	DT
cord-022594-fx044gcd	908	9	chronic	chronic	JJ
cord-022594-fx044gcd	908	10	progression	progression	NN
cord-022594-fx044gcd	908	11	of	of	IN
cord-022594-fx044gcd	908	12	MS	MS	NNP
cord-022594-fx044gcd	908	13	,	,	,
cord-022594-fx044gcd	908	14	but	but	CC
cord-022594-fx044gcd	908	15	because	because	IN
cord-022594-fx044gcd	908	16	this	this	DT
cord-022594-fx044gcd	908	17	approach	approach	NN
cord-022594-fx044gcd	908	18	precludes	preclude	VBZ
cord-022594-fx044gcd	908	19	the	the	DT
cord-022594-fx044gcd	908	20	later	later	JJ
cord-022594-fx044gcd	908	21	initiation	initiation	NN
cord-022594-fx044gcd	908	22	of	of	IN
cord-022594-fx044gcd	908	23	immunosuppressant	immunosuppressant	JJ
cord-022594-fx044gcd	908	24	drugs	drug	NNS
cord-022594-fx044gcd	908	25	and	and	CC
cord-022594-fx044gcd	908	26	may	may	MD
cord-022594-fx044gcd	908	27	be	be	VB
cord-022594-fx044gcd	908	28	associated	associate	VBN
cord-022594-fx044gcd	908	29	with	with	IN
cord-022594-fx044gcd	908	30	a	a	DT
cord-022594-fx044gcd	908	31	higher	high	JJR
cord-022594-fx044gcd	908	32	mortality	mortality	NN
cord-022594-fx044gcd	908	33	rate	rate	NN
cord-022594-fx044gcd	908	34	,	,	,
cord-022594-fx044gcd	908	35	it	-PRON-	PRP
cord-022594-fx044gcd	908	36	is	be	VBZ
cord-022594-fx044gcd	908	37	not	not	RB
cord-022594-fx044gcd	908	38	widely	widely	RB
cord-022594-fx044gcd	908	39	used	use	VBN
cord-022594-fx044gcd	908	40	.	.	.
cord-022594-fx044gcd	909	1	Cladribine	Cladribine	NNP
cord-022594-fx044gcd	909	2	is	be	VBZ
cord-022594-fx044gcd	909	3	a	a	DT
cord-022594-fx044gcd	909	4	nucleoside	nucleoside	NN
cord-022594-fx044gcd	909	5	derivative	derivative	JJ
cord-022594-fx044gcd	909	6	that	that	WDT
cord-022594-fx044gcd	909	7	was	be	VBD
cord-022594-fx044gcd	909	8	found	find	VBN
cord-022594-fx044gcd	909	9	to	to	TO
cord-022594-fx044gcd	909	10	decrease	decrease	VB
cord-022594-fx044gcd	909	11	relapse	relapse	NN
cord-022594-fx044gcd	909	12	rate	rate	NN
cord-022594-fx044gcd	909	13	and	and	CC
cord-022594-fx044gcd	909	14	slow	slow	VB
cord-022594-fx044gcd	909	15	the	the	DT
cord-022594-fx044gcd	909	16	progression	progression	NN
cord-022594-fx044gcd	909	17	in	in	IN
cord-022594-fx044gcd	909	18	patients	patient	NNS
cord-022594-fx044gcd	909	19	with	with	IN
cord-022594-fx044gcd	909	20	SPMS	SPMS	NNP
cord-022594-fx044gcd	909	21	in	in	IN
cord-022594-fx044gcd	909	22	an	an	DT
cord-022594-fx044gcd	909	23	initial	initial	JJ
cord-022594-fx044gcd	909	24	investigation	investigation	NN
cord-022594-fx044gcd	909	25	.	.	.
cord-022594-fx044gcd	910	1	103	103	CD
cord-022594-fx044gcd	911	1	The	the	DT
cord-022594-fx044gcd	911	2	drug	drug	NN
cord-022594-fx044gcd	911	3	is	be	VBZ
cord-022594-fx044gcd	911	4	better	well	RBR
cord-022594-fx044gcd	911	5	tolerated	tolerate	VBN
cord-022594-fx044gcd	911	6	than	than	IN
cord-022594-fx044gcd	911	7	other	other	JJ
cord-022594-fx044gcd	911	8	parenteral	parenteral	JJ
cord-022594-fx044gcd	911	9	immunosuppressants	immunosuppressant	NNS
cord-022594-fx044gcd	911	10	,	,	,
cord-022594-fx044gcd	911	11	although	although	IN
cord-022594-fx044gcd	911	12	bone	bone	NN
cord-022594-fx044gcd	911	13	marrow	marrow	NN
cord-022594-fx044gcd	911	14	suppression	suppression	NN
cord-022594-fx044gcd	911	15	is	be	VBZ
cord-022594-fx044gcd	911	16	a	a	DT
cord-022594-fx044gcd	911	17	risk	risk	NN
cord-022594-fx044gcd	911	18	.	.	.
cord-022594-fx044gcd	912	1	In	in	IN
cord-022594-fx044gcd	912	2	a	a	DT
cord-022594-fx044gcd	912	3	more	more	RBR
cord-022594-fx044gcd	912	4	extensive	extensive	JJ
cord-022594-fx044gcd	912	5	clinical	clinical	JJ
cord-022594-fx044gcd	912	6	trial	trial	NN
cord-022594-fx044gcd	912	7	,	,	,
cord-022594-fx044gcd	912	8	104	104	CD
cord-022594-fx044gcd	912	9	cladribine	cladribine	NN
cord-022594-fx044gcd	912	10	therapy	therapy	NN
cord-022594-fx044gcd	912	11	did	do	VBD
cord-022594-fx044gcd	912	12	not	not	RB
cord-022594-fx044gcd	912	13	change	change	VB
cord-022594-fx044gcd	912	14	disability	disability	NN
cord-022594-fx044gcd	912	15	scores	score	NNS
cord-022594-fx044gcd	912	16	,	,	,
cord-022594-fx044gcd	912	17	but	but	CC
cord-022594-fx044gcd	912	18	significant	significant	JJ
cord-022594-fx044gcd	912	19	reduction	reduction	NN
cord-022594-fx044gcd	912	20	in	in	IN
cord-022594-fx044gcd	912	21	enhancing	enhance	VBG
cord-022594-fx044gcd	912	22	lesions	lesion	NNS
cord-022594-fx044gcd	912	23	and	and	CC
cord-022594-fx044gcd	912	24	overall	overall	JJ
cord-022594-fx044gcd	912	25	T2	T2	NNP
cord-022594-fx044gcd	912	26	lesion	lesion	NN
cord-022594-fx044gcd	912	27	burden	burden	NN
cord-022594-fx044gcd	912	28	was	be	VBD
cord-022594-fx044gcd	912	29	observed	observe	VBN
cord-022594-fx044gcd	912	30	with	with	IN
cord-022594-fx044gcd	912	31	higher	high	JJR
cord-022594-fx044gcd	912	32	dose	dose	NN
cord-022594-fx044gcd	912	33	treatment	treatment	NN
cord-022594-fx044gcd	912	34	.	.	.
cord-022594-fx044gcd	913	1	A	a	DT
cord-022594-fx044gcd	913	2	study	study	NN
cord-022594-fx044gcd	913	3	of	of	IN
cord-022594-fx044gcd	913	4	a	a	DT
cord-022594-fx044gcd	913	5	small	small	JJ
cord-022594-fx044gcd	913	6	number	number	NN
cord-022594-fx044gcd	913	7	of	of	IN
cord-022594-fx044gcd	913	8	patients	patient	NNS
cord-022594-fx044gcd	913	9	treated	treat	VBN
cord-022594-fx044gcd	913	10	with	with	IN
cord-022594-fx044gcd	913	11	autologous	autologous	JJ
cord-022594-fx044gcd	913	12	stem	stem	NN
cord-022594-fx044gcd	913	13	cell	cell	NN
cord-022594-fx044gcd	913	14	transplantation	transplantation	NN
cord-022594-fx044gcd	913	15	105	105	CD
cord-022594-fx044gcd	913	16	suggested	suggest	VBD
cord-022594-fx044gcd	913	17	possible	possible	JJ
cord-022594-fx044gcd	913	18	clinical	clinical	JJ
cord-022594-fx044gcd	913	19	stabilization	stabilization	NN
cord-022594-fx044gcd	913	20	or	or	CC
cord-022594-fx044gcd	913	21	minor	minor	JJ
cord-022594-fx044gcd	913	22	improvement	improvement	NN
cord-022594-fx044gcd	913	23	over	over	IN
cord-022594-fx044gcd	913	24	a	a	DT
cord-022594-fx044gcd	913	25	15-month	15-month	JJ
cord-022594-fx044gcd	913	26	period	period	NN
cord-022594-fx044gcd	913	27	of	of	IN
cord-022594-fx044gcd	913	28	follow	follow	NN
cord-022594-fx044gcd	913	29	-	-	HYPH
cord-022594-fx044gcd	913	30	up	up	NN
cord-022594-fx044gcd	913	31	in	in	IN
cord-022594-fx044gcd	913	32	both	both	CC
cord-022594-fx044gcd	913	33	secondary	secondary	JJ
cord-022594-fx044gcd	913	34	and	and	CC
cord-022594-fx044gcd	913	35	primary	primary	JJ
cord-022594-fx044gcd	913	36	progressive	progressive	JJ
cord-022594-fx044gcd	913	37	MS	MS	NNP
cord-022594-fx044gcd	913	38	.	.	.
cord-022594-fx044gcd	914	1	The	the	DT
cord-022594-fx044gcd	914	2	induction	induction	NN
cord-022594-fx044gcd	914	3	chemotherapy	chemotherapy	NN
cord-022594-fx044gcd	914	4	(	(	-LRB-
cord-022594-fx044gcd	914	5	BEAM	BEAM	NNP
cord-022594-fx044gcd	914	6	regimen	regimen	NN
cord-022594-fx044gcd	914	7	)	)	-RRB-
cord-022594-fx044gcd	914	8	resulted	result	VBD
cord-022594-fx044gcd	914	9	in	in	IN
cord-022594-fx044gcd	914	10	one	one	CD
cord-022594-fx044gcd	914	11	fatality	fatality	NN
cord-022594-fx044gcd	914	12	in	in	IN
cord-022594-fx044gcd	914	13	this	this	DT
cord-022594-fx044gcd	914	14	trial	trial	NN
cord-022594-fx044gcd	914	15	;	;	:
cord-022594-fx044gcd	914	16	similar	similar	JJ
cord-022594-fx044gcd	914	17	incidences	incidence	NNS
cord-022594-fx044gcd	914	18	are	be	VBP
cord-022594-fx044gcd	914	19	known	know	VBN
cord-022594-fx044gcd	914	20	in	in	IN
cord-022594-fx044gcd	914	21	patients	patient	NNS
cord-022594-fx044gcd	914	22	undergoing	undergo	VBG
cord-022594-fx044gcd	914	23	this	this	DT
cord-022594-fx044gcd	914	24	procedure	procedure	NN
cord-022594-fx044gcd	914	25	.	.	.
cord-022594-fx044gcd	915	1	The	the	DT
cord-022594-fx044gcd	915	2	small	small	JJ
cord-022594-fx044gcd	915	3	number	number	NN
cord-022594-fx044gcd	915	4	of	of	IN
cord-022594-fx044gcd	915	5	patients	patient	NNS
cord-022594-fx044gcd	915	6	and	and	CC
cord-022594-fx044gcd	915	7	the	the	DT
cord-022594-fx044gcd	915	8	different	different	JJ
cord-022594-fx044gcd	915	9	methods	method	NNS
cord-022594-fx044gcd	915	10	used	use	VBN
cord-022594-fx044gcd	915	11	(	(	-LRB-
cord-022594-fx044gcd	915	12	some	some	DT
cord-022594-fx044gcd	915	13	patients	patient	NNS
cord-022594-fx044gcd	915	14	received	receive	VBD
cord-022594-fx044gcd	915	15	CD34	CD34	NNP
cord-022594-fx044gcd	915	16	þ	þ	NNP
cord-022594-fx044gcd	915	17	selected	select	VBD
cord-022594-fx044gcd	915	18	graft	graft	NN
cord-022594-fx044gcd	915	19	)	)	-RRB-
cord-022594-fx044gcd	915	20	makes	make	VBZ
cord-022594-fx044gcd	915	21	the	the	DT
cord-022594-fx044gcd	915	22	interpretation	interpretation	NN
cord-022594-fx044gcd	915	23	of	of	IN
cord-022594-fx044gcd	915	24	this	this	DT
cord-022594-fx044gcd	915	25	data	datum	NNS
cord-022594-fx044gcd	915	26	very	very	RB
cord-022594-fx044gcd	915	27	difficult	difficult	JJ
cord-022594-fx044gcd	915	28	.	.	.
cord-022594-fx044gcd	916	1	Trials	trial	NNS
cord-022594-fx044gcd	916	2	with	with	IN
cord-022594-fx044gcd	916	3	higher	high	JJR
cord-022594-fx044gcd	916	4	number	number	NN
cord-022594-fx044gcd	916	5	of	of	IN
cord-022594-fx044gcd	916	6	patients	patient	NNS
cord-022594-fx044gcd	916	7	under	under	IN
cord-022594-fx044gcd	916	8	standardized	standardized	JJ
cord-022594-fx044gcd	916	9	circumstances	circumstance	NNS
cord-022594-fx044gcd	916	10	are	be	VBP
cord-022594-fx044gcd	916	11	needed	need	VBN
cord-022594-fx044gcd	916	12	to	to	TO
cord-022594-fx044gcd	916	13	verify	verify	VB
cord-022594-fx044gcd	916	14	the	the	DT
cord-022594-fx044gcd	916	15	validity	validity	NN
cord-022594-fx044gcd	916	16	of	of	IN
cord-022594-fx044gcd	916	17	these	these	DT
cord-022594-fx044gcd	916	18	observations	observation	NNS
cord-022594-fx044gcd	916	19	.	.	.
cord-022594-fx044gcd	917	1	Symptomatic	symptomatic	JJ
cord-022594-fx044gcd	917	2	Treatment	treatment	NN
cord-022594-fx044gcd	917	3	of	of	IN
cord-022594-fx044gcd	917	4	Existing	exist	VBG
cord-022594-fx044gcd	917	5	Disabilities	Disabilities	NNPS
cord-022594-fx044gcd	917	6	Spasticity	Spasticity	NNP
cord-022594-fx044gcd	917	7	.	.	.
cord-022594-fx044gcd	918	1	Spasticity	Spasticity	NNP
cord-022594-fx044gcd	918	2	is	be	VBZ
cord-022594-fx044gcd	918	3	common	common	JJ
cord-022594-fx044gcd	918	4	even	even	RB
cord-022594-fx044gcd	918	5	in	in	IN
cord-022594-fx044gcd	918	6	patients	patient	NNS
cord-022594-fx044gcd	918	7	with	with	IN
cord-022594-fx044gcd	918	8	only	only	JJ
cord-022594-fx044gcd	918	9	minimal	minimal	JJ
cord-022594-fx044gcd	918	10	weakness	weakness	NN
cord-022594-fx044gcd	918	11	(	(	-LRB-
cord-022594-fx044gcd	918	12	Video	Video	NNP
cord-022594-fx044gcd	918	13	3	3	CD
cord-022594-fx044gcd	918	14	,	,	,
cord-022594-fx044gcd	918	15	Spastic	Spastic	NNP
cord-022594-fx044gcd	918	16	Gait	Gait	NNP
cord-022594-fx044gcd	918	17	)	)	-RRB-
cord-022594-fx044gcd	918	18	.	.	.
cord-022594-fx044gcd	919	1	It	-PRON-	PRP
cord-022594-fx044gcd	919	2	is	be	VBZ
cord-022594-fx044gcd	919	3	usually	usually	RB
cord-022594-fx044gcd	919	4	prudent	prudent	JJ
cord-022594-fx044gcd	919	5	to	to	TO
cord-022594-fx044gcd	919	6	begin	begin	VB
cord-022594-fx044gcd	919	7	treatment	treatment	NN
cord-022594-fx044gcd	919	8	of	of	IN
cord-022594-fx044gcd	919	9	mild	mild	JJ
cord-022594-fx044gcd	919	10	spasticity	spasticity	NN
cord-022594-fx044gcd	919	11	with	with	IN
cord-022594-fx044gcd	919	12	a	a	DT
cord-022594-fx044gcd	919	13	stretching	stretch	VBG
cord-022594-fx044gcd	919	14	program	program	NN
cord-022594-fx044gcd	919	15	.	.	.
cord-022594-fx044gcd	920	1	A	a	DT
cord-022594-fx044gcd	920	2	randomized	randomized	JJ
cord-022594-fx044gcd	920	3	controlled	control	VBN
cord-022594-fx044gcd	920	4	crossover	crossover	NN
cord-022594-fx044gcd	920	5	trial	trial	NN
cord-022594-fx044gcd	920	6	106	106	CD
cord-022594-fx044gcd	920	7	of	of	IN
cord-022594-fx044gcd	920	8	physical	physical	JJ
cord-022594-fx044gcd	920	9	therapy	therapy	NN
cord-022594-fx044gcd	920	10	(	(	-LRB-
cord-022594-fx044gcd	920	11	8-week	8-week	JJ
cord-022594-fx044gcd	920	12	blocks	block	NNS
cord-022594-fx044gcd	920	13	of	of	IN
cord-022594-fx044gcd	920	14	therapy	therapy	NN
cord-022594-fx044gcd	920	15	twice	twice	PDT
cord-022594-fx044gcd	920	16	a	a	DT
cord-022594-fx044gcd	920	17	week	week	NN
cord-022594-fx044gcd	920	18	,	,	,
cord-022594-fx044gcd	920	19	for	for	IN
cord-022594-fx044gcd	920	20	45	45	CD
cord-022594-fx044gcd	920	21	minutes	minute	NNS
cord-022594-fx044gcd	920	22	per	per	IN
cord-022594-fx044gcd	920	23	session	session	NN
cord-022594-fx044gcd	920	24	)	)	-RRB-
cord-022594-fx044gcd	920	25	showed	show	VBD
cord-022594-fx044gcd	920	26	significant	significant	JJ
cord-022594-fx044gcd	920	27	benefit	benefit	NN
cord-022594-fx044gcd	920	28	on	on	IN
cord-022594-fx044gcd	920	29	several	several	JJ
cord-022594-fx044gcd	920	30	outcome	outcome	NN
cord-022594-fx044gcd	920	31	measures	measure	NNS
cord-022594-fx044gcd	920	32	related	relate	VBN
cord-022594-fx044gcd	920	33	to	to	IN
cord-022594-fx044gcd	920	34	improved	improve	VBN
cord-022594-fx044gcd	920	35	mobility	mobility	NN
cord-022594-fx044gcd	920	36	.	.	.
cord-022594-fx044gcd	921	1	No	no	DT
cord-022594-fx044gcd	921	2	apparent	apparent	JJ
cord-022594-fx044gcd	921	3	differences	difference	NNS
cord-022594-fx044gcd	921	4	were	be	VBD
cord-022594-fx044gcd	921	5	observed	observe	VBN
cord-022594-fx044gcd	921	6	between	between	IN
cord-022594-fx044gcd	921	7	home	home	NN
cord-022594-fx044gcd	921	8	-	-	HYPH
cord-022594-fx044gcd	921	9	based	base	VBN
cord-022594-fx044gcd	921	10	or	or	CC
cord-022594-fx044gcd	921	11	hospital	hospital	NN
cord-022594-fx044gcd	921	12	-	-	HYPH
cord-022594-fx044gcd	921	13	based	base	VBN
cord-022594-fx044gcd	921	14	therapy	therapy	NN
cord-022594-fx044gcd	921	15	.	.	.
cord-022594-fx044gcd	922	1	The	the	DT
cord-022594-fx044gcd	922	2	addition	addition	NN
cord-022594-fx044gcd	922	3	of	of	IN
cord-022594-fx044gcd	922	4	an	an	DT
cord-022594-fx044gcd	922	5	evening	evening	NN
cord-022594-fx044gcd	922	6	dose	dose	NN
cord-022594-fx044gcd	922	7	of	of	IN
cord-022594-fx044gcd	922	8	benzodiazepine	benzodiazepine	NN
cord-022594-fx044gcd	922	9	may	may	MD
cord-022594-fx044gcd	922	10	help	help	VB
cord-022594-fx044gcd	922	11	relieve	relieve	VB
cord-022594-fx044gcd	922	12	extensor	extensor	JJ
cord-022594-fx044gcd	922	13	spasms	spasm	NNS
cord-022594-fx044gcd	922	14	and	and	CC
cord-022594-fx044gcd	922	15	clonus	clonus	NN
cord-022594-fx044gcd	922	16	that	that	WDT
cord-022594-fx044gcd	922	17	may	may	MD
cord-022594-fx044gcd	922	18	interfere	interfere	VB
cord-022594-fx044gcd	922	19	with	with	IN
cord-022594-fx044gcd	922	20	sleep	sleep	NN
cord-022594-fx044gcd	922	21	.	.	.
cord-022594-fx044gcd	923	1	As	as	IN
cord-022594-fx044gcd	923	2	spasticity	spasticity	NN
cord-022594-fx044gcd	923	3	worsens	worsen	VBZ
cord-022594-fx044gcd	923	4	,	,	,
cord-022594-fx044gcd	923	5	it	-PRON-	PRP
cord-022594-fx044gcd	923	6	becomes	become	VBZ
cord-022594-fx044gcd	923	7	necessary	necessary	JJ
cord-022594-fx044gcd	923	8	to	to	TO
cord-022594-fx044gcd	923	9	use	use	VB
cord-022594-fx044gcd	923	10	baclofen	baclofen	NN
cord-022594-fx044gcd	923	11	.	.	.
cord-022594-fx044gcd	924	1	Doses	dose	NNS
cord-022594-fx044gcd	924	2	should	should	MD
cord-022594-fx044gcd	924	3	be	be	VB
cord-022594-fx044gcd	924	4	escalated	escalate	VBN
cord-022594-fx044gcd	924	5	slowly	slowly	RB
cord-022594-fx044gcd	924	6	to	to	TO
cord-022594-fx044gcd	924	7	prevent	prevent	VB
cord-022594-fx044gcd	924	8	the	the	DT
cord-022594-fx044gcd	924	9	occurrence	occurrence	NN
cord-022594-fx044gcd	924	10	of	of	IN
cord-022594-fx044gcd	924	11	overt	overt	JJ
cord-022594-fx044gcd	924	12	side	side	NN
cord-022594-fx044gcd	924	13	effects	effect	NNS
cord-022594-fx044gcd	924	14	,	,	,
cord-022594-fx044gcd	924	15	and	and	CC
cord-022594-fx044gcd	924	16	up	up	IN
cord-022594-fx044gcd	924	17	to	to	TO
cord-022594-fx044gcd	924	18	120	120	CD
cord-022594-fx044gcd	924	19	mg	mg	NNP
cord-022594-fx044gcd	924	20	/	/	SYM
cord-022594-fx044gcd	924	21	day	day	NN
cord-022594-fx044gcd	924	22	may	may	MD
cord-022594-fx044gcd	924	23	be	be	VB
cord-022594-fx044gcd	924	24	required	require	VBN
cord-022594-fx044gcd	924	25	.	.	.
cord-022594-fx044gcd	925	1	Although	although	IN
cord-022594-fx044gcd	925	2	baclofen	baclofen	NN
cord-022594-fx044gcd	925	3	is	be	VBZ
cord-022594-fx044gcd	925	4	well	well	RB
cord-022594-fx044gcd	925	5	tolerated	tolerate	VBN
cord-022594-fx044gcd	925	6	in	in	IN
cord-022594-fx044gcd	925	7	most	most	JJS
cord-022594-fx044gcd	925	8	patients	patient	NNS
cord-022594-fx044gcd	925	9	,	,	,
cord-022594-fx044gcd	925	10	limiting	limit	VBG
cord-022594-fx044gcd	925	11	side	side	NN
cord-022594-fx044gcd	925	12	effects	effect	NNS
cord-022594-fx044gcd	925	13	such	such	JJ
cord-022594-fx044gcd	925	14	as	as	IN
cord-022594-fx044gcd	925	15	sedation	sedation	NN
cord-022594-fx044gcd	925	16	and	and	CC
cord-022594-fx044gcd	925	17	increased	increase	VBN
cord-022594-fx044gcd	925	18	muscle	muscle	NN
cord-022594-fx044gcd	925	19	weakness	weakness	NN
cord-022594-fx044gcd	925	20	may	may	MD
cord-022594-fx044gcd	925	21	occur	occur	VB
cord-022594-fx044gcd	925	22	,	,	,
cord-022594-fx044gcd	925	23	and	and	CC
cord-022594-fx044gcd	925	24	rarely	rarely	RB
cord-022594-fx044gcd	925	25	a	a	DT
cord-022594-fx044gcd	925	26	paradoxical	paradoxical	JJ
cord-022594-fx044gcd	925	27	increase	increase	NN
cord-022594-fx044gcd	925	28	in	in	IN
cord-022594-fx044gcd	925	29	spasticity	spasticity	NN
cord-022594-fx044gcd	925	30	is	be	VBZ
cord-022594-fx044gcd	925	31	noted	note	VBN
cord-022594-fx044gcd	925	32	.	.	.
cord-022594-fx044gcd	926	1	Liver	liver	NN
cord-022594-fx044gcd	926	2	enzyme	enzyme	NN
cord-022594-fx044gcd	926	3	elevation	elevation	NN
cord-022594-fx044gcd	926	4	and	and	CC
cord-022594-fx044gcd	926	5	nonconvulsive	nonconvulsive	JJ
cord-022594-fx044gcd	926	6	status	status	NN
cord-022594-fx044gcd	926	7	epilepticus	epilepticus	NN
cord-022594-fx044gcd	926	8	presenting	present	VBG
cord-022594-fx044gcd	926	9	as	as	IN
cord-022594-fx044gcd	926	10	encephalopathy	encephalopathy	NN
cord-022594-fx044gcd	926	11	have	have	VBP
cord-022594-fx044gcd	926	12	also	also	RB
cord-022594-fx044gcd	926	13	been	be	VBN
cord-022594-fx044gcd	926	14	reported	report	VBN
cord-022594-fx044gcd	926	15	in	in	IN
cord-022594-fx044gcd	926	16	association	association	NN
cord-022594-fx044gcd	926	17	with	with	IN
cord-022594-fx044gcd	926	18	baclofen	baclofen	NNP
cord-022594-fx044gcd	926	19	.	.	.
cord-022594-fx044gcd	927	1	Abrupt	abrupt	JJ
cord-022594-fx044gcd	927	2	withdrawal	withdrawal	NN
cord-022594-fx044gcd	927	3	of	of	IN
cord-022594-fx044gcd	927	4	baclofen	baclofen	NN
cord-022594-fx044gcd	927	5	may	may	MD
cord-022594-fx044gcd	927	6	result	result	VB
cord-022594-fx044gcd	927	7	in	in	IN
cord-022594-fx044gcd	927	8	hallucinations	hallucination	NNS
cord-022594-fx044gcd	927	9	or	or	CC
cord-022594-fx044gcd	927	10	seizures	seizure	NNS
cord-022594-fx044gcd	927	11	,	,	,
cord-022594-fx044gcd	927	12	making	make	VBG
cord-022594-fx044gcd	927	13	it	-PRON-	PRP
cord-022594-fx044gcd	927	14	necessary	necessary	JJ
cord-022594-fx044gcd	927	15	to	to	TO
cord-022594-fx044gcd	927	16	taper	taper	VB
cord-022594-fx044gcd	927	17	doses	dose	NNS
cord-022594-fx044gcd	927	18	.	.	.
cord-022594-fx044gcd	928	1	Despite	despite	IN
cord-022594-fx044gcd	928	2	symptomatic	symptomatic	JJ
cord-022594-fx044gcd	928	3	improvement	improvement	NN
cord-022594-fx044gcd	928	4	,	,	,
cord-022594-fx044gcd	928	5	antispasticity	antispasticity	NN
cord-022594-fx044gcd	928	6	measures	measure	NNS
cord-022594-fx044gcd	928	7	may	may	MD
cord-022594-fx044gcd	928	8	not	not	RB
cord-022594-fx044gcd	928	9	increase	increase	VB
cord-022594-fx044gcd	928	10	function	function	NN
cord-022594-fx044gcd	928	11	or	or	CC
cord-022594-fx044gcd	928	12	independence	independence	NN
cord-022594-fx044gcd	928	13	.	.	.
cord-022594-fx044gcd	929	1	In	in	IN
cord-022594-fx044gcd	929	2	paraplegic	paraplegic	JJ
cord-022594-fx044gcd	929	3	patients	patient	NNS
cord-022594-fx044gcd	929	4	with	with	IN
cord-022594-fx044gcd	929	5	severe	severe	JJ
cord-022594-fx044gcd	929	6	spasticity	spasticity	NN
cord-022594-fx044gcd	929	7	and	and	CC
cord-022594-fx044gcd	929	8	intolerance	intolerance	NN
cord-022594-fx044gcd	929	9	to	to	IN
cord-022594-fx044gcd	929	10	the	the	DT
cord-022594-fx044gcd	929	11	required	require	VBN
cord-022594-fx044gcd	929	12	oral	oral	JJ
cord-022594-fx044gcd	929	13	dose	dose	NN
cord-022594-fx044gcd	929	14	,	,	,
cord-022594-fx044gcd	929	15	intrathecal	intrathecal	JJ
cord-022594-fx044gcd	929	16	baclofen	baclofen	NN
cord-022594-fx044gcd	929	17	delivered	deliver	VBN
cord-022594-fx044gcd	929	18	by	by	IN
cord-022594-fx044gcd	929	19	a	a	DT
cord-022594-fx044gcd	929	20	subcutaneously	subcutaneously	RB
cord-022594-fx044gcd	929	21	implanted	implant	VBN
cord-022594-fx044gcd	929	22	pump	pump	NN
cord-022594-fx044gcd	929	23	allows	allow	VBZ
cord-022594-fx044gcd	929	24	a	a	DT
cord-022594-fx044gcd	929	25	much	much	RB
cord-022594-fx044gcd	929	26	smaller	small	JJR
cord-022594-fx044gcd	929	27	dose	dose	NN
cord-022594-fx044gcd	929	28	and	and	CC
cord-022594-fx044gcd	929	29	is	be	VBZ
cord-022594-fx044gcd	929	30	often	often	RB
cord-022594-fx044gcd	929	31	effective	effective	JJ
cord-022594-fx044gcd	929	32	in	in	IN
cord-022594-fx044gcd	929	33	alleviating	alleviate	VBG
cord-022594-fx044gcd	929	34	intractable	intractable	JJ
cord-022594-fx044gcd	929	35	spasticity	spasticity	NN
cord-022594-fx044gcd	929	36	and	and	CC
cord-022594-fx044gcd	929	37	may	may	MD
cord-022594-fx044gcd	929	38	lessen	lessen	VB
cord-022594-fx044gcd	929	39	urinary	urinary	JJ
cord-022594-fx044gcd	929	40	urgency	urgency	NN
cord-022594-fx044gcd	929	41	.	.	.
cord-022594-fx044gcd	930	1	Tizanidine	Tizanidine	NNP
cord-022594-fx044gcd	930	2	seems	seem	VBZ
cord-022594-fx044gcd	930	3	to	to	TO
cord-022594-fx044gcd	930	4	be	be	VB
cord-022594-fx044gcd	930	5	as	as	RB
cord-022594-fx044gcd	930	6	effective	effective	JJ
cord-022594-fx044gcd	930	7	as	as	IN
cord-022594-fx044gcd	930	8	baclofen	baclofen	NN
cord-022594-fx044gcd	930	9	,	,	,
cord-022594-fx044gcd	930	10	although	although	IN
cord-022594-fx044gcd	930	11	it	-PRON-	PRP
cord-022594-fx044gcd	930	12	may	may	MD
cord-022594-fx044gcd	930	13	be	be	VB
cord-022594-fx044gcd	930	14	associated	associate	VBN
cord-022594-fx044gcd	930	15	with	with	IN
cord-022594-fx044gcd	930	16	more	more	JJR
cord-022594-fx044gcd	930	17	fatigue	fatigue	NN
cord-022594-fx044gcd	930	18	.	.	.
cord-022594-fx044gcd	931	1	Dantrolene	Dantrolene	NNP
cord-022594-fx044gcd	931	2	has	have	VBZ
cord-022594-fx044gcd	931	3	been	be	VBN
cord-022594-fx044gcd	931	4	used	use	VBN
cord-022594-fx044gcd	931	5	for	for	IN
cord-022594-fx044gcd	931	6	spasticity	spasticity	NN
cord-022594-fx044gcd	931	7	,	,	,
cord-022594-fx044gcd	931	8	although	although	IN
cord-022594-fx044gcd	931	9	the	the	DT
cord-022594-fx044gcd	931	10	therapeutic	therapeutic	JJ
cord-022594-fx044gcd	931	11	window	window	NN
cord-022594-fx044gcd	931	12	is	be	VBZ
cord-022594-fx044gcd	931	13	small	small	JJ
cord-022594-fx044gcd	931	14	.	.	.
cord-022594-fx044gcd	932	1	Fatigue	fatigue	NN
cord-022594-fx044gcd	932	2	.	.	.
cord-022594-fx044gcd	933	1	For	for	IN
cord-022594-fx044gcd	933	2	treating	treat	VBG
cord-022594-fx044gcd	933	3	fatigue	fatigue	NN
cord-022594-fx044gcd	933	4	,	,	,
cord-022594-fx044gcd	933	5	medications	medication	NNS
cord-022594-fx044gcd	933	6	are	be	VBP
cord-022594-fx044gcd	933	7	only	only	RB
cord-022594-fx044gcd	933	8	partially	partially	RB
cord-022594-fx044gcd	933	9	effective	effective	JJ
cord-022594-fx044gcd	933	10	.	.	.
cord-022594-fx044gcd	934	1	Amantadine	Amantadine	NNP
cord-022594-fx044gcd	934	2	at	at	IN
cord-022594-fx044gcd	934	3	100	100	CD
cord-022594-fx044gcd	934	4	mg	mg	NNS
cord-022594-fx044gcd	934	5	twice	twice	PDT
cord-022594-fx044gcd	934	6	a	a	DT
cord-022594-fx044gcd	934	7	day	day	NN
cord-022594-fx044gcd	934	8	is	be	VBZ
cord-022594-fx044gcd	934	9	the	the	DT
cord-022594-fx044gcd	934	10	standard	standard	JJ
cord-022594-fx044gcd	934	11	initial	initial	JJ
cord-022594-fx044gcd	934	12	treatment	treatment	NN
cord-022594-fx044gcd	934	13	,	,	,
cord-022594-fx044gcd	934	14	although	although	IN
cord-022594-fx044gcd	934	15	pemoline	pemoline	NNP
cord-022594-fx044gcd	934	16	37.5	37.5	CD
cord-022594-fx044gcd	934	17	mg	mg	NNP
cord-022594-fx044gcd	934	18	daily	daily	RB
cord-022594-fx044gcd	934	19	is	be	VBZ
cord-022594-fx044gcd	934	20	also	also	RB
cord-022594-fx044gcd	934	21	superior	superior	JJ
cord-022594-fx044gcd	934	22	to	to	IN
cord-022594-fx044gcd	934	23	placebo	placebo	NN
cord-022594-fx044gcd	934	24	.	.	.
cord-022594-fx044gcd	935	1	A	a	DT
cord-022594-fx044gcd	935	2	recent	recent	JJ
cord-022594-fx044gcd	935	3	,	,	,
cord-022594-fx044gcd	935	4	small	small	JJ
cord-022594-fx044gcd	935	5	pilot	pilot	NN
cord-022594-fx044gcd	935	6	study	study	NN
cord-022594-fx044gcd	935	7	by	by	IN
cord-022594-fx044gcd	935	8	the	the	DT
cord-022594-fx044gcd	935	9	Mayo	Mayo	NNP
cord-022594-fx044gcd	935	10	group	group	NN
cord-022594-fx044gcd	935	11	suggested	suggest	VBD
cord-022594-fx044gcd	935	12	that	that	IN
cord-022594-fx044gcd	935	13	high	high	JJ
cord-022594-fx044gcd	935	14	-	-	HYPH
cord-022594-fx044gcd	935	15	dose	dose	NN
cord-022594-fx044gcd	935	16	aspirin	aspirin	NN
cord-022594-fx044gcd	935	17	(	(	-LRB-
cord-022594-fx044gcd	935	18	1300	1300	CD
cord-022594-fx044gcd	935	19	mg	mg	NNP
cord-022594-fx044gcd	935	20	/	/	SYM
cord-022594-fx044gcd	935	21	day	day	NN
cord-022594-fx044gcd	935	22	)	)	-RRB-
cord-022594-fx044gcd	935	23	may	may	MD
cord-022594-fx044gcd	935	24	sometimes	sometimes	RB
cord-022594-fx044gcd	935	25	be	be	VB
cord-022594-fx044gcd	935	26	effective	effective	JJ
cord-022594-fx044gcd	935	27	in	in	IN
cord-022594-fx044gcd	935	28	the	the	DT
cord-022594-fx044gcd	935	29	treatment	treatment	NN
cord-022594-fx044gcd	935	30	of	of	IN
cord-022594-fx044gcd	935	31	MS	MS	NNP
cord-022594-fx044gcd	935	32	-	-	HYPH
cord-022594-fx044gcd	935	33	related	relate	VBN
cord-022594-fx044gcd	935	34	fatigue	fatigue	NN
cord-022594-fx044gcd	935	35	.	.	.
cord-022594-fx044gcd	936	1	107	107	CD
cord-022594-fx044gcd	937	1	This	this	DT
cord-022594-fx044gcd	937	2	finding	finding	NN
cord-022594-fx044gcd	937	3	needs	need	VBZ
cord-022594-fx044gcd	937	4	to	to	TO
cord-022594-fx044gcd	937	5	be	be	VB
cord-022594-fx044gcd	937	6	confirmed	confirm	VBN
cord-022594-fx044gcd	937	7	by	by	IN
cord-022594-fx044gcd	937	8	a	a	DT
cord-022594-fx044gcd	937	9	second	second	JJ
cord-022594-fx044gcd	937	10	,	,	,
cord-022594-fx044gcd	937	11	larger	large	JJR
cord-022594-fx044gcd	937	12	trial	trial	NN
cord-022594-fx044gcd	937	13	,	,	,
cord-022594-fx044gcd	937	14	however	however	RB
cord-022594-fx044gcd	937	15	.	.	.
cord-022594-fx044gcd	938	1	The	the	DT
cord-022594-fx044gcd	938	2	stimulating	stimulating	JJ
cord-022594-fx044gcd	938	3	effects	effect	NNS
cord-022594-fx044gcd	938	4	of	of	IN
cord-022594-fx044gcd	938	5	the	the	DT
cord-022594-fx044gcd	938	6	selective	selective	JJ
cord-022594-fx044gcd	938	7	serotonin	serotonin	NN
cord-022594-fx044gcd	938	8	reuptake	reuptake	NN
cord-022594-fx044gcd	938	9	inhibitors	inhibitor	NNS
cord-022594-fx044gcd	938	10	may	may	MD
cord-022594-fx044gcd	938	11	also	also	RB
cord-022594-fx044gcd	938	12	be	be	VB
cord-022594-fx044gcd	938	13	somewhat	somewhat	RB
cord-022594-fx044gcd	938	14	effective	effective	JJ
cord-022594-fx044gcd	938	15	in	in	IN
cord-022594-fx044gcd	938	16	combating	combat	VBG
cord-022594-fx044gcd	938	17	MS	MS	NNP
cord-022594-fx044gcd	938	18	-	-	HYPH
cord-022594-fx044gcd	938	19	related	relate	VBN
cord-022594-fx044gcd	938	20	fatigue	fatigue	NN
cord-022594-fx044gcd	938	21	.	.	.
cord-022594-fx044gcd	939	1	Modafinil	Modafinil	NNP
cord-022594-fx044gcd	939	2	,	,	,
cord-022594-fx044gcd	939	3	a	a	DT
cord-022594-fx044gcd	939	4	medication	medication	NN
cord-022594-fx044gcd	939	5	approved	approve	VBN
cord-022594-fx044gcd	939	6	for	for	IN
cord-022594-fx044gcd	939	7	the	the	DT
cord-022594-fx044gcd	939	8	treatment	treatment	NN
cord-022594-fx044gcd	939	9	of	of	IN
cord-022594-fx044gcd	939	10	narcolepsy	narcolepsy	NN
cord-022594-fx044gcd	939	11	,	,	,
cord-022594-fx044gcd	939	12	has	have	VBZ
cord-022594-fx044gcd	939	13	also	also	RB
cord-022594-fx044gcd	939	14	been	be	VBN
cord-022594-fx044gcd	939	15	used	use	VBN
cord-022594-fx044gcd	939	16	with	with	IN
cord-022594-fx044gcd	939	17	good	good	JJ
cord-022594-fx044gcd	939	18	success	success	NN
cord-022594-fx044gcd	939	19	.	.	.
cord-022594-fx044gcd	940	1	Often	often	RB
cord-022594-fx044gcd	940	2	,	,	,
cord-022594-fx044gcd	940	3	however	however	RB
cord-022594-fx044gcd	940	4	,	,	,
cord-022594-fx044gcd	940	5	patients	patient	NNS
cord-022594-fx044gcd	940	6	need	need	VBP
cord-022594-fx044gcd	940	7	to	to	TO
cord-022594-fx044gcd	940	8	limit	limit	VB
cord-022594-fx044gcd	940	9	activities	activity	NNS
cord-022594-fx044gcd	940	10	and	and	CC
cord-022594-fx044gcd	940	11	schedule	schedule	NN
cord-022594-fx044gcd	940	12	rest	rest	NN
cord-022594-fx044gcd	940	13	periods	period	NNS
cord-022594-fx044gcd	940	14	.	.	.
cord-022594-fx044gcd	941	1	Paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	941	2	Symptoms	symptom	NNS
cord-022594-fx044gcd	941	3	of	of	IN
cord-022594-fx044gcd	941	4	MS	MS	NNP
cord-022594-fx044gcd	941	5	.	.	.
cord-022594-fx044gcd	942	1	Paroxysmal	paroxysmal	JJ
cord-022594-fx044gcd	942	2	symptoms	symptom	NNS
cord-022594-fx044gcd	942	3	are	be	VBP
cord-022594-fx044gcd	942	4	highly	highly	RB
cord-022594-fx044gcd	942	5	responsive	responsive	JJ
cord-022594-fx044gcd	942	6	to	to	IN
cord-022594-fx044gcd	942	7	medical	medical	JJ
cord-022594-fx044gcd	942	8	treatment	treatment	NN
cord-022594-fx044gcd	942	9	.	.	.
cord-022594-fx044gcd	943	1	A	a	DT
cord-022594-fx044gcd	943	2	small	small	JJ
cord-022594-fx044gcd	943	3	dose	dose	NN
cord-022594-fx044gcd	943	4	of	of	IN
cord-022594-fx044gcd	943	5	carbamazepine	carbamazepine	NN
cord-022594-fx044gcd	943	6	is	be	VBZ
cord-022594-fx044gcd	943	7	often	often	RB
cord-022594-fx044gcd	943	8	very	very	RB
cord-022594-fx044gcd	943	9	effective	effective	JJ
cord-022594-fx044gcd	943	10	.	.	.
cord-022594-fx044gcd	944	1	If	if	IN
cord-022594-fx044gcd	944	2	not	not	RB
cord-022594-fx044gcd	944	3	tolerated	tolerate	VBN
cord-022594-fx044gcd	944	4	,	,	,
cord-022594-fx044gcd	944	5	several	several	JJ
cord-022594-fx044gcd	944	6	alternative	alternative	JJ
cord-022594-fx044gcd	944	7	medications	medication	NNS
cord-022594-fx044gcd	944	8	may	may	MD
cord-022594-fx044gcd	944	9	be	be	VB
cord-022594-fx044gcd	944	10	tried	try	VBN
cord-022594-fx044gcd	944	11	,	,	,
cord-022594-fx044gcd	944	12	including	include	VBG
cord-022594-fx044gcd	944	13	phenytoin	phenytoin	NN
cord-022594-fx044gcd	944	14	,	,	,
cord-022594-fx044gcd	944	15	acetazolamide	acetazolamide	NN
cord-022594-fx044gcd	944	16	,	,	,
cord-022594-fx044gcd	944	17	baclofen	baclofen	NN
cord-022594-fx044gcd	944	18	,	,	,
cord-022594-fx044gcd	944	19	and	and	CC
cord-022594-fx044gcd	944	20	gabapentin	gabapentin	NNP
cord-022594-fx044gcd	944	21	.	.	.
cord-022594-fx044gcd	945	1	In	in	IN
cord-022594-fx044gcd	945	2	addition	addition	NN
cord-022594-fx044gcd	945	3	,	,	,
cord-022594-fx044gcd	945	4	misoprostol	misoprostol	NNP
cord-022594-fx044gcd	945	5	has	have	VBZ
cord-022594-fx044gcd	945	6	been	be	VBN
cord-022594-fx044gcd	945	7	claimed	claim	VBN
cord-022594-fx044gcd	945	8	to	to	TO
cord-022594-fx044gcd	945	9	be	be	VB
cord-022594-fx044gcd	945	10	effective	effective	JJ
cord-022594-fx044gcd	945	11	in	in	IN
cord-022594-fx044gcd	945	12	MS	MS	NNP
cord-022594-fx044gcd	945	13	-	-	HYPH
cord-022594-fx044gcd	945	14	related	relate	VBN
cord-022594-fx044gcd	945	15	trigeminal	trigeminal	JJ
cord-022594-fx044gcd	945	16	neuralgia	neuralgia	NN
cord-022594-fx044gcd	945	17	.	.	.
cord-022594-fx044gcd	946	1	After	after	IN
cord-022594-fx044gcd	946	2	about	about	RB
cord-022594-fx044gcd	946	3	1	1	CD
cord-022594-fx044gcd	946	4	month	month	NN
cord-022594-fx044gcd	946	5	of	of	IN
cord-022594-fx044gcd	946	6	treatment	treatment	NN
cord-022594-fx044gcd	946	7	,	,	,
cord-022594-fx044gcd	946	8	a	a	DT
cord-022594-fx044gcd	946	9	periodic	periodic	JJ
cord-022594-fx044gcd	946	10	attempt	attempt	NN
cord-022594-fx044gcd	946	11	at	at	IN
cord-022594-fx044gcd	946	12	tapering	taper	VBG
cord-022594-fx044gcd	946	13	off	off	RP
cord-022594-fx044gcd	946	14	these	these	DT
cord-022594-fx044gcd	946	15	medications	medication	NNS
cord-022594-fx044gcd	946	16	is	be	VBZ
cord-022594-fx044gcd	946	17	a	a	DT
cord-022594-fx044gcd	946	18	reasonable	reasonable	JJ
cord-022594-fx044gcd	946	19	approach	approach	NN
cord-022594-fx044gcd	946	20	because	because	IN
cord-022594-fx044gcd	946	21	these	these	DT
cord-022594-fx044gcd	946	22	symptoms	symptom	NNS
cord-022594-fx044gcd	946	23	usually	usually	RB
cord-022594-fx044gcd	946	24	remit	remit	VBP
cord-022594-fx044gcd	946	25	.	.	.
cord-022594-fx044gcd	947	1	Seizures	seizure	NNS
cord-022594-fx044gcd	947	2	in	in	IN
cord-022594-fx044gcd	947	3	MS	MS	NNP
cord-022594-fx044gcd	947	4	are	be	VBP
cord-022594-fx044gcd	947	5	treated	treat	VBN
cord-022594-fx044gcd	947	6	no	no	RB
cord-022594-fx044gcd	947	7	differently	differently	RB
cord-022594-fx044gcd	947	8	than	than	IN
cord-022594-fx044gcd	947	9	in	in	IN
cord-022594-fx044gcd	947	10	non	non	JJ
cord-022594-fx044gcd	947	11	-	-	JJ
cord-022594-fx044gcd	947	12	MS	ms	JJ
cord-022594-fx044gcd	947	13	conditions	condition	NNS
cord-022594-fx044gcd	947	14	.	.	.
cord-022594-fx044gcd	948	1	Heat	heat	NN
cord-022594-fx044gcd	948	2	Sensitivity	sensitivity	NN
cord-022594-fx044gcd	948	3	.	.	.
cord-022594-fx044gcd	949	1	Heat	heat	NN
cord-022594-fx044gcd	949	2	sensitivity	sensitivity	NN
cord-022594-fx044gcd	949	3	may	may	MD
cord-022594-fx044gcd	949	4	require	require	VB
cord-022594-fx044gcd	949	5	avoidance	avoidance	NN
cord-022594-fx044gcd	949	6	of	of	IN
cord-022594-fx044gcd	949	7	precipitating	precipitate	VBG
cord-022594-fx044gcd	949	8	activities	activity	NNS
cord-022594-fx044gcd	949	9	,	,	,
cord-022594-fx044gcd	949	10	but	but	CC
cord-022594-fx044gcd	949	11	this	this	DT
cord-022594-fx044gcd	949	12	depends	depend	VBZ
cord-022594-fx044gcd	949	13	on	on	IN
cord-022594-fx044gcd	949	14	the	the	DT
cord-022594-fx044gcd	949	15	nature	nature	NN
cord-022594-fx044gcd	949	16	of	of	IN
cord-022594-fx044gcd	949	17	symptoms	symptom	NNS
cord-022594-fx044gcd	949	18	and	and	CC
cord-022594-fx044gcd	949	19	the	the	DT
cord-022594-fx044gcd	949	20	situation	situation	NN
cord-022594-fx044gcd	949	21	in	in	IN
cord-022594-fx044gcd	949	22	which	which	WDT
cord-022594-fx044gcd	949	23	they	-PRON-	PRP
cord-022594-fx044gcd	949	24	occur	occur	VBP
cord-022594-fx044gcd	949	25	.	.	.
cord-022594-fx044gcd	950	1	If	if	IN
cord-022594-fx044gcd	950	2	the	the	DT
cord-022594-fx044gcd	950	3	precipitating	precipitate	VBG
cord-022594-fx044gcd	950	4	activity	activity	NN
cord-022594-fx044gcd	950	5	can	can	MD
cord-022594-fx044gcd	950	6	not	not	RB
cord-022594-fx044gcd	950	7	be	be	VB
cord-022594-fx044gcd	950	8	avoided	avoid	VBN
cord-022594-fx044gcd	950	9	,	,	,
cord-022594-fx044gcd	950	10	a	a	DT
cord-022594-fx044gcd	950	11	cooling	cool	VBG
cord-022594-fx044gcd	950	12	jacket	jacket	NN
cord-022594-fx044gcd	950	13	may	may	MD
cord-022594-fx044gcd	950	14	be	be	VB
cord-022594-fx044gcd	950	15	an	an	DT
cord-022594-fx044gcd	950	16	option	option	NN
cord-022594-fx044gcd	950	17	.	.	.
cord-022594-fx044gcd	951	1	A	a	DT
cord-022594-fx044gcd	951	2	potassium	potassium	NN
cord-022594-fx044gcd	951	3	channel	channel	NN
cord-022594-fx044gcd	951	4	blocker	blocker	NN
cord-022594-fx044gcd	951	5	,	,	,
cord-022594-fx044gcd	951	6	4-aminopyridine	4-aminopyridine	CD
cord-022594-fx044gcd	951	7	,	,	,
cord-022594-fx044gcd	951	8	improves	improve	VBZ
cord-022594-fx044gcd	951	9	temperature	temperature	NN
cord-022594-fx044gcd	951	10	sensitivity	sensitivity	NN
cord-022594-fx044gcd	951	11	in	in	IN
cord-022594-fx044gcd	951	12	some	some	DT
cord-022594-fx044gcd	951	13	patients	patient	NNS
cord-022594-fx044gcd	951	14	but	but	CC
cord-022594-fx044gcd	951	15	occasionally	occasionally	RB
cord-022594-fx044gcd	951	16	causes	cause	VBZ
cord-022594-fx044gcd	951	17	seizures	seizure	NNS
cord-022594-fx044gcd	951	18	or	or	CC
cord-022594-fx044gcd	951	19	disturbing	disturb	VBG
cord-022594-fx044gcd	951	20	paresthesias	paresthesia	NNS
cord-022594-fx044gcd	951	21	.	.	.
cord-022594-fx044gcd	952	1	Action	Action	NNP
cord-022594-fx044gcd	952	2	Tremor	Tremor	NNP
cord-022594-fx044gcd	952	3	.	.	.
cord-022594-fx044gcd	953	1	Action	action	NN
cord-022594-fx044gcd	953	2	tremor	tremor	NN
cord-022594-fx044gcd	953	3	is	be	VBZ
cord-022594-fx044gcd	953	4	a	a	DT
cord-022594-fx044gcd	953	5	common	common	JJ
cord-022594-fx044gcd	953	6	disabling	disable	VBG
cord-022594-fx044gcd	953	7	symptom	symptom	NN
cord-022594-fx044gcd	953	8	(	(	-LRB-
cord-022594-fx044gcd	953	9	Video	Video	NNP
cord-022594-fx044gcd	953	10	14	14	CD
cord-022594-fx044gcd	953	11	,	,	,
cord-022594-fx044gcd	953	12	Tremor	Tremor	NNP
cord-022594-fx044gcd	953	13	with	with	IN
cord-022594-fx044gcd	953	14	Ataxia	Ataxia	NNP
cord-022594-fx044gcd	953	15	)	)	-RRB-
cord-022594-fx044gcd	953	16	.	.	.
cord-022594-fx044gcd	954	1	Unfortunately	unfortunately	RB
cord-022594-fx044gcd	954	2	,	,	,
cord-022594-fx044gcd	954	3	it	-PRON-	PRP
cord-022594-fx044gcd	954	4	is	be	VBZ
cord-022594-fx044gcd	954	5	often	often	RB
cord-022594-fx044gcd	954	6	only	only	RB
cord-022594-fx044gcd	954	7	marginally	marginally	RB
cord-022594-fx044gcd	954	8	amenable	amenable	JJ
cord-022594-fx044gcd	954	9	to	to	IN
cord-022594-fx044gcd	954	10	medical	medical	JJ
cord-022594-fx044gcd	954	11	therapy	therapy	NN
cord-022594-fx044gcd	954	12	.	.	.
cord-022594-fx044gcd	955	1	Clonazepam	Clonazepam	NNP
cord-022594-fx044gcd	955	2	may	may	MD
cord-022594-fx044gcd	955	3	offer	offer	VB
cord-022594-fx044gcd	955	4	some	some	DT
cord-022594-fx044gcd	955	5	relief	relief	NN
cord-022594-fx044gcd	955	6	,	,	,
cord-022594-fx044gcd	955	7	but	but	CC
cord-022594-fx044gcd	955	8	tolerance	tolerance	NN
cord-022594-fx044gcd	955	9	frequently	frequently	RB
cord-022594-fx044gcd	955	10	develops	develop	VBZ
cord-022594-fx044gcd	955	11	,	,	,
cord-022594-fx044gcd	955	12	necessitating	necessitate	VBG
cord-022594-fx044gcd	955	13	increasing	increase	VBG
cord-022594-fx044gcd	955	14	doses	dose	NNS
cord-022594-fx044gcd	955	15	.	.	.
cord-022594-fx044gcd	956	1	Isoniazid	Isoniazid	NNP
cord-022594-fx044gcd	956	2	and	and	CC
cord-022594-fx044gcd	956	3	carbamazepine	carbamazepine	NN
cord-022594-fx044gcd	956	4	have	have	VBP
cord-022594-fx044gcd	956	5	also	also	RB
cord-022594-fx044gcd	956	6	been	be	VBN
cord-022594-fx044gcd	956	7	found	find	VBN
cord-022594-fx044gcd	956	8	marginally	marginally	RB
cord-022594-fx044gcd	956	9	beneficial	beneficial	JJ
cord-022594-fx044gcd	956	10	.	.	.
cord-022594-fx044gcd	957	1	One	one	CD
cord-022594-fx044gcd	957	2	clinical	clinical	JJ
cord-022594-fx044gcd	957	3	trial	trial	NN
cord-022594-fx044gcd	957	4	showed	show	VBD
cord-022594-fx044gcd	957	5	ondansetron	ondansetron	NN
cord-022594-fx044gcd	957	6	to	to	TO
cord-022594-fx044gcd	957	7	reduce	reduce	VB
cord-022594-fx044gcd	957	8	tremor	tremor	NN
cord-022594-fx044gcd	957	9	-	-	HYPH
cord-022594-fx044gcd	957	10	related	relate	VBN
cord-022594-fx044gcd	957	11	disability	disability	NN
cord-022594-fx044gcd	957	12	.	.	.
cord-022594-fx044gcd	958	1	Anecdotal	anecdotal	JJ
cord-022594-fx044gcd	958	2	reports	report	NNS
cord-022594-fx044gcd	958	3	suggest	suggest	VBP
cord-022594-fx044gcd	958	4	that	that	IN
cord-022594-fx044gcd	958	5	gabapentin	gabapentin	NNP
cord-022594-fx044gcd	958	6	may	may	MD
cord-022594-fx044gcd	958	7	be	be	VB
cord-022594-fx044gcd	958	8	partially	partially	RB
cord-022594-fx044gcd	958	9	effective	effective	JJ
cord-022594-fx044gcd	958	10	.	.	.
cord-022594-fx044gcd	959	1	Improvements	improvement	NNS
cord-022594-fx044gcd	959	2	in	in	IN
cord-022594-fx044gcd	959	3	stereotactic	stereotactic	NNP
cord-022594-fx044gcd	959	4	neurosurgery	neurosurgery	NNP
cord-022594-fx044gcd	959	5	have	have	VBP
cord-022594-fx044gcd	959	6	made	make	VBN
cord-022594-fx044gcd	959	7	thalamotomy	thalamotomy	IN
cord-022594-fx044gcd	959	8	a	a	DT
cord-022594-fx044gcd	959	9	legitimate	legitimate	JJ
cord-022594-fx044gcd	959	10	option	option	NN
cord-022594-fx044gcd	959	11	in	in	IN
cord-022594-fx044gcd	959	12	those	those	DT
cord-022594-fx044gcd	959	13	whose	whose	WP$
cord-022594-fx044gcd	959	14	disability	disability	NN
cord-022594-fx044gcd	959	15	is	be	VBZ
cord-022594-fx044gcd	959	16	mainly	mainly	RB
cord-022594-fx044gcd	959	17	due	due	JJ
cord-022594-fx044gcd	959	18	to	to	IN
cord-022594-fx044gcd	959	19	tremor	tremor	NN
cord-022594-fx044gcd	959	20	and	and	CC
cord-022594-fx044gcd	959	21	not	not	RB
cord-022594-fx044gcd	959	22	ataxia	ataxia	NN
cord-022594-fx044gcd	959	23	.	.	.
cord-022594-fx044gcd	960	1	Cognitive	cognitive	JJ
cord-022594-fx044gcd	960	2	and	and	CC
cord-022594-fx044gcd	960	3	Memory	Memory	NNP
cord-022594-fx044gcd	960	4	Problems	problem	NNS
cord-022594-fx044gcd	960	5	.	.	.
cord-022594-fx044gcd	961	1	Cognitive	cognitive	JJ
cord-022594-fx044gcd	961	2	problems	problem	NNS
cord-022594-fx044gcd	961	3	can	can	MD
cord-022594-fx044gcd	961	4	also	also	RB
cord-022594-fx044gcd	961	5	be	be	VB
cord-022594-fx044gcd	961	6	seen	see	VBN
cord-022594-fx044gcd	961	7	in	in	IN
cord-022594-fx044gcd	961	8	MS	MS	NNP
cord-022594-fx044gcd	961	9	patients	patient	NNS
cord-022594-fx044gcd	961	10	.	.	.
cord-022594-fx044gcd	962	1	These	these	DT
cord-022594-fx044gcd	962	2	symptoms	symptom	NNS
cord-022594-fx044gcd	962	3	are	be	VBP
cord-022594-fx044gcd	962	4	generally	generally	RB
cord-022594-fx044gcd	962	5	not	not	RB
cord-022594-fx044gcd	962	6	very	very	RB
cord-022594-fx044gcd	962	7	severe	severe	JJ
cord-022594-fx044gcd	962	8	;	;	:
cord-022594-fx044gcd	962	9	however	however	RB
cord-022594-fx044gcd	962	10	,	,	,
cord-022594-fx044gcd	962	11	in	in	IN
cord-022594-fx044gcd	962	12	some	some	DT
cord-022594-fx044gcd	962	13	patients	patient	NNS
cord-022594-fx044gcd	962	14	these	these	DT
cord-022594-fx044gcd	962	15	may	may	MD
cord-022594-fx044gcd	962	16	be	be	VB
cord-022594-fx044gcd	962	17	one	one	CD
cord-022594-fx044gcd	962	18	of	of	IN
cord-022594-fx044gcd	962	19	their	-PRON-	PRP$
cord-022594-fx044gcd	962	20	subjectively	subjectively	RB
cord-022594-fx044gcd	962	21	most	most	RBS
cord-022594-fx044gcd	962	22	bothersome	bothersome	JJ
cord-022594-fx044gcd	962	23	complaints	complaint	NNS
cord-022594-fx044gcd	962	24	.	.	.
cord-022594-fx044gcd	963	1	It	-PRON-	PRP
cord-022594-fx044gcd	963	2	is	be	VBZ
cord-022594-fx044gcd	963	3	important	important	JJ
cord-022594-fx044gcd	963	4	to	to	TO
cord-022594-fx044gcd	963	5	make	make	VB
cord-022594-fx044gcd	963	6	sure	sure	JJ
cord-022594-fx044gcd	963	7	that	that	IN
cord-022594-fx044gcd	963	8	such	such	JJ
cord-022594-fx044gcd	963	9	complaints	complaint	NNS
cord-022594-fx044gcd	963	10	are	be	VBP
cord-022594-fx044gcd	963	11	not	not	RB
cord-022594-fx044gcd	963	12	depression	depression	NN
cord-022594-fx044gcd	963	13	related	relate	VBN
cord-022594-fx044gcd	963	14	,	,	,
cord-022594-fx044gcd	963	15	as	as	IN
cord-022594-fx044gcd	963	16	mood	mood	NN
cord-022594-fx044gcd	963	17	disorders	disorder	NNS
cord-022594-fx044gcd	963	18	are	be	VBP
cord-022594-fx044gcd	963	19	otherwise	otherwise	RB
cord-022594-fx044gcd	963	20	rather	rather	RB
cord-022594-fx044gcd	963	21	common	common	JJ
cord-022594-fx044gcd	963	22	in	in	IN
cord-022594-fx044gcd	963	23	MS	MS	NNP
cord-022594-fx044gcd	963	24	,	,	,
cord-022594-fx044gcd	963	25	and	and	CC
cord-022594-fx044gcd	963	26	may	may	MD
cord-022594-fx044gcd	963	27	explain	explain	VB
cord-022594-fx044gcd	963	28	the	the	DT
cord-022594-fx044gcd	963	29	subjective	subjective	JJ
cord-022594-fx044gcd	963	30	cognitive	cognitive	JJ
cord-022594-fx044gcd	963	31	impairment	impairment	NN
cord-022594-fx044gcd	963	32	.	.	.
cord-022594-fx044gcd	964	1	While	while	IN
cord-022594-fx044gcd	964	2	it	-PRON-	PRP
cord-022594-fx044gcd	964	3	is	be	VBZ
cord-022594-fx044gcd	964	4	not	not	RB
cord-022594-fx044gcd	964	5	FDA	FDA	NNP
cord-022594-fx044gcd	964	6	approved	approve	VBN
cord-022594-fx044gcd	964	7	for	for	IN
cord-022594-fx044gcd	964	8	the	the	DT
cord-022594-fx044gcd	964	9	treatment	treatment	NN
cord-022594-fx044gcd	964	10	of	of	IN
cord-022594-fx044gcd	964	11	MS	MS	NNP
cord-022594-fx044gcd	964	12	related	relate	VBD
cord-022594-fx044gcd	964	13	cognitive	cognitive	JJ
cord-022594-fx044gcd	964	14	dysfunction	dysfunction	NN
cord-022594-fx044gcd	964	15	,	,	,
cord-022594-fx044gcd	964	16	in	in	IN
cord-022594-fx044gcd	964	17	a	a	DT
cord-022594-fx044gcd	964	18	placebo	placebo	NN
cord-022594-fx044gcd	964	19	controlled	control	VBN
cord-022594-fx044gcd	964	20	,	,	,
cord-022594-fx044gcd	964	21	randomized	randomized	JJ
cord-022594-fx044gcd	964	22	,	,	,
cord-022594-fx044gcd	964	23	24-week	24-week	JJ
cord-022594-fx044gcd	964	24	long	long	JJ
cord-022594-fx044gcd	964	25	study	study	NN
cord-022594-fx044gcd	964	26	of	of	IN
cord-022594-fx044gcd	964	27	donepezil	donepezil	NNP
cord-022594-fx044gcd	964	28	in	in	IN
cord-022594-fx044gcd	964	29	69	69	CD
cord-022594-fx044gcd	964	30	patients	patient	NNS
cord-022594-fx044gcd	964	31	,	,	,
cord-022594-fx044gcd	964	32	significant	significant	JJ
cord-022594-fx044gcd	964	33	improvement	improvement	NN
cord-022594-fx044gcd	964	34	was	be	VBD
cord-022594-fx044gcd	964	35	found	find	VBN
cord-022594-fx044gcd	964	36	on	on	IN
cord-022594-fx044gcd	964	37	the	the	DT
cord-022594-fx044gcd	964	38	Selective	selective	JJ
cord-022594-fx044gcd	964	39	Reminding	reminding	NN
cord-022594-fx044gcd	964	40	Test	test	NN
cord-022594-fx044gcd	964	41	(	(	-LRB-
cord-022594-fx044gcd	964	42	SRT	SRT	NNP
cord-022594-fx044gcd	964	43	)	)	-RRB-
cord-022594-fx044gcd	964	44	.	.	.
cord-022594-fx044gcd	965	1	108	108	CD
cord-022594-fx044gcd	966	1	This	this	DT
cord-022594-fx044gcd	966	2	improvement	improvement	NN
cord-022594-fx044gcd	966	3	was	be	VBD
cord-022594-fx044gcd	966	4	independent	independent	JJ
cord-022594-fx044gcd	966	5	of	of	IN
cord-022594-fx044gcd	966	6	MS	MS	NNP
cord-022594-fx044gcd	966	7	subtype	subtype	NN
cord-022594-fx044gcd	966	8	,	,	,
cord-022594-fx044gcd	966	9	gender	gender	NN
cord-022594-fx044gcd	966	10	,	,	,
cord-022594-fx044gcd	966	11	age	age	NN
cord-022594-fx044gcd	966	12	,	,	,
cord-022594-fx044gcd	966	13	reading	read	VBG
cord-022594-fx044gcd	966	14	ability	ability	NN
cord-022594-fx044gcd	966	15	,	,	,
cord-022594-fx044gcd	966	16	and	and	CC
cord-022594-fx044gcd	966	17	baseline	baseline	JJ
cord-022594-fx044gcd	966	18	SRT	SRT	NNP
cord-022594-fx044gcd	966	19	results	result	NNS
cord-022594-fx044gcd	966	20	.	.	.
cord-022594-fx044gcd	967	1	The	the	DT
cord-022594-fx044gcd	967	2	patients	patient	NNS
cord-022594-fx044gcd	967	3	did	do	VBD
cord-022594-fx044gcd	967	4	not	not	RB
cord-022594-fx044gcd	967	5	improve	improve	VB
cord-022594-fx044gcd	967	6	on	on	IN
cord-022594-fx044gcd	967	7	other	other	JJ
cord-022594-fx044gcd	967	8	cognitive	cognitive	JJ
cord-022594-fx044gcd	967	9	scales	scale	NNS
cord-022594-fx044gcd	967	10	,	,	,
cord-022594-fx044gcd	967	11	but	but	CC
cord-022594-fx044gcd	967	12	they	-PRON-	PRP
cord-022594-fx044gcd	967	13	were	be	VBD
cord-022594-fx044gcd	967	14	twice	twice	RB
cord-022594-fx044gcd	967	15	as	as	RB
cord-022594-fx044gcd	967	16	likely	likely	JJ
cord-022594-fx044gcd	967	17	to	to	TO
cord-022594-fx044gcd	967	18	report	report	VB
cord-022594-fx044gcd	967	19	cognitive	cognitive	JJ
cord-022594-fx044gcd	967	20	improvement	improvement	NN
cord-022594-fx044gcd	967	21	.	.	.
cord-022594-fx044gcd	968	1	Dysesthetic	dysesthetic	JJ
cord-022594-fx044gcd	968	2	Pain	Pain	NNP
cord-022594-fx044gcd	968	3	.	.	.
cord-022594-fx044gcd	969	1	Dysesthetic	dysesthetic	JJ
cord-022594-fx044gcd	969	2	pains	pain	NNS
cord-022594-fx044gcd	969	3	are	be	VBP
cord-022594-fx044gcd	969	4	difficult	difficult	JJ
cord-022594-fx044gcd	969	5	to	to	TO
cord-022594-fx044gcd	969	6	control	control	VB
cord-022594-fx044gcd	969	7	but	but	CC
cord-022594-fx044gcd	969	8	sometimes	sometimes	RB
cord-022594-fx044gcd	969	9	respond	respond	VB
cord-022594-fx044gcd	969	10	to	to	IN
cord-022594-fx044gcd	969	11	tricyclic	tricyclic	JJ
cord-022594-fx044gcd	969	12	antidepressants	antidepressant	NNS
cord-022594-fx044gcd	969	13	,	,	,
cord-022594-fx044gcd	969	14	carbamazepine	carbamazepine	NN
cord-022594-fx044gcd	969	15	,	,	,
cord-022594-fx044gcd	969	16	or	or	CC
cord-022594-fx044gcd	969	17	baclofen	baclofen	NN
cord-022594-fx044gcd	969	18	.	.	.
cord-022594-fx044gcd	970	1	Gabapentin	gabapentin	UH
cord-022594-fx044gcd	970	2	,	,	,
cord-022594-fx044gcd	970	3	tramadol	tramadol	NN
cord-022594-fx044gcd	970	4	,	,	,
cord-022594-fx044gcd	970	5	and	and	CC
cord-022594-fx044gcd	970	6	duloxetine	duloxetine	NNP
cord-022594-fx044gcd	970	7	may	may	MD
cord-022594-fx044gcd	970	8	also	also	RB
cord-022594-fx044gcd	970	9	be	be	VB
cord-022594-fx044gcd	970	10	effective	effective	JJ
cord-022594-fx044gcd	970	11	.	.	.
cord-022594-fx044gcd	971	1	Standard	standard	JJ
cord-022594-fx044gcd	971	2	analgesics	analgesic	NNS
cord-022594-fx044gcd	971	3	are	be	VBP
cord-022594-fx044gcd	971	4	not	not	RB
cord-022594-fx044gcd	971	5	often	often	RB
cord-022594-fx044gcd	971	6	useful	useful	JJ
cord-022594-fx044gcd	971	7	in	in	IN
cord-022594-fx044gcd	971	8	MS	MS	NNP
cord-022594-fx044gcd	971	9	-	-	HYPH
cord-022594-fx044gcd	971	10	associated	associate	VBN
cord-022594-fx044gcd	971	11	pain	pain	NN
cord-022594-fx044gcd	971	12	,	,	,
cord-022594-fx044gcd	971	13	and	and	CC
cord-022594-fx044gcd	971	14	narcotics	narcotic	NNS
cord-022594-fx044gcd	971	15	should	should	MD
cord-022594-fx044gcd	971	16	be	be	VB
cord-022594-fx044gcd	971	17	avoided	avoid	VBN
cord-022594-fx044gcd	971	18	in	in	IN
cord-022594-fx044gcd	971	19	the	the	DT
cord-022594-fx044gcd	971	20	treatment	treatment	NN
cord-022594-fx044gcd	971	21	of	of	IN
cord-022594-fx044gcd	971	22	chronic	chronic	JJ
cord-022594-fx044gcd	971	23	pain	pain	NN
cord-022594-fx044gcd	971	24	.	.	.
cord-022594-fx044gcd	972	1	Emotional	emotional	JJ
cord-022594-fx044gcd	972	2	incontinence	incontinence	NN
cord-022594-fx044gcd	972	3	may	may	MD
cord-022594-fx044gcd	972	4	be	be	VB
cord-022594-fx044gcd	972	5	amenable	amenable	JJ
cord-022594-fx044gcd	972	6	to	to	IN
cord-022594-fx044gcd	972	7	a	a	DT
cord-022594-fx044gcd	972	8	low	low	JJ
cord-022594-fx044gcd	972	9	dose	dose	NN
cord-022594-fx044gcd	972	10	of	of	IN
cord-022594-fx044gcd	972	11	a	a	DT
cord-022594-fx044gcd	972	12	tricyclic	tricyclic	NN
cord-022594-fx044gcd	972	13	antidepressant	antidepressant	NN
cord-022594-fx044gcd	972	14	(	(	-LRB-
cord-022594-fx044gcd	972	15	Video	Video	NNP
cord-022594-fx044gcd	972	16	10	10	CD
cord-022594-fx044gcd	972	17	,	,	,
cord-022594-fx044gcd	972	18	Dysarthria	Dysarthria	NNP
cord-022594-fx044gcd	972	19	)	)	-RRB-
cord-022594-fx044gcd	972	20	.	.	.
cord-022594-fx044gcd	973	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	973	2	of	of	IN
cord-022594-fx044gcd	973	3	Bladder	Bladder	NNP
cord-022594-fx044gcd	973	4	Dysfunction	Dysfunction	NNP
cord-022594-fx044gcd	973	5	.	.	.
cord-022594-fx044gcd	974	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	974	2	of	of	IN
cord-022594-fx044gcd	974	3	a	a	DT
cord-022594-fx044gcd	974	4	hyper	hyper	JJ
cord-022594-fx044gcd	974	5	-	-	NN
cord-022594-fx044gcd	974	6	reflexic	reflexic	JJ
cord-022594-fx044gcd	974	7	bladder	bladder	NN
cord-022594-fx044gcd	974	8	(	(	-LRB-
cord-022594-fx044gcd	974	9	urgency	urgency	NN
cord-022594-fx044gcd	974	10	,	,	,
cord-022594-fx044gcd	974	11	frequency	frequency	NN
cord-022594-fx044gcd	974	12	,	,	,
cord-022594-fx044gcd	974	13	and	and	CC
cord-022594-fx044gcd	974	14	urge	urge	VB
cord-022594-fx044gcd	974	15	incontinence	incontinence	NN
cord-022594-fx044gcd	974	16	)	)	-RRB-
cord-022594-fx044gcd	974	17	are	be	VBP
cord-022594-fx044gcd	974	18	often	often	RB
cord-022594-fx044gcd	974	19	manageable	manageable	JJ
cord-022594-fx044gcd	974	20	with	with	IN
cord-022594-fx044gcd	974	21	anticholinergics	anticholinergic	NNS
cord-022594-fx044gcd	974	22	such	such	JJ
cord-022594-fx044gcd	974	23	as	as	IN
cord-022594-fx044gcd	974	24	oxybutynin	oxybutynin	NNP
cord-022594-fx044gcd	974	25	,	,	,
cord-022594-fx044gcd	974	26	propantheline	propantheline	NNP
cord-022594-fx044gcd	974	27	,	,	,
cord-022594-fx044gcd	974	28	or	or	CC
cord-022594-fx044gcd	974	29	imipramine	imipramine	NN
cord-022594-fx044gcd	974	30	.	.	.
cord-022594-fx044gcd	975	1	A	a	DT
cord-022594-fx044gcd	975	2	flaccid	flaccid	JJ
cord-022594-fx044gcd	975	3	bladder	bladder	NN
cord-022594-fx044gcd	975	4	can	can	MD
cord-022594-fx044gcd	975	5	sometimes	sometimes	RB
cord-022594-fx044gcd	975	6	be	be	VB
cord-022594-fx044gcd	975	7	aided	aid	VBN
cord-022594-fx044gcd	975	8	by	by	IN
cord-022594-fx044gcd	975	9	bethanechol	bethanechol	NNP
cord-022594-fx044gcd	975	10	,	,	,
cord-022594-fx044gcd	975	11	although	although	IN
cord-022594-fx044gcd	975	12	intermittent	intermittent	JJ
cord-022594-fx044gcd	975	13	self	self	NN
cord-022594-fx044gcd	975	14	-	-	HYPH
cord-022594-fx044gcd	975	15	catheterization	catheterization	NN
cord-022594-fx044gcd	975	16	is	be	VBZ
cord-022594-fx044gcd	975	17	more	more	RBR
cord-022594-fx044gcd	975	18	often	often	RB
cord-022594-fx044gcd	975	19	needed	need	VBN
cord-022594-fx044gcd	975	20	.	.	.
cord-022594-fx044gcd	976	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	976	2	that	that	WDT
cord-022594-fx044gcd	976	3	suggest	suggest	VBP
cord-022594-fx044gcd	976	4	urinary	urinary	JJ
cord-022594-fx044gcd	976	5	retention	retention	NN
cord-022594-fx044gcd	976	6	(	(	-LRB-
cord-022594-fx044gcd	976	7	a	a	DT
cord-022594-fx044gcd	976	8	feeling	feeling	NN
cord-022594-fx044gcd	976	9	of	of	IN
cord-022594-fx044gcd	976	10	incomplete	incomplete	JJ
cord-022594-fx044gcd	976	11	emptying	emptying	NN
cord-022594-fx044gcd	976	12	,	,	,
cord-022594-fx044gcd	976	13	frequency	frequency	NN
cord-022594-fx044gcd	976	14	,	,	,
cord-022594-fx044gcd	976	15	hesitancy	hesitancy	NN
cord-022594-fx044gcd	976	16	,	,	,
cord-022594-fx044gcd	976	17	or	or	CC
cord-022594-fx044gcd	976	18	a	a	DT
cord-022594-fx044gcd	976	19	need	need	NN
cord-022594-fx044gcd	976	20	to	to	TO
cord-022594-fx044gcd	976	21	apply	apply	VB
cord-022594-fx044gcd	976	22	pressure	pressure	NN
cord-022594-fx044gcd	976	23	to	to	IN
cord-022594-fx044gcd	976	24	the	the	DT
cord-022594-fx044gcd	976	25	lower	low	JJR
cord-022594-fx044gcd	976	26	abdomen	abdomen	NN
cord-022594-fx044gcd	976	27	to	to	TO
cord-022594-fx044gcd	976	28	urinate	urinate	VB
cord-022594-fx044gcd	976	29	)	)	-RRB-
cord-022594-fx044gcd	976	30	should	should	MD
cord-022594-fx044gcd	976	31	prompt	prompt	VB
cord-022594-fx044gcd	976	32	evaluation	evaluation	NN
cord-022594-fx044gcd	976	33	with	with	IN
cord-022594-fx044gcd	976	34	urinalysis	urinalysis	NN
cord-022594-fx044gcd	976	35	and	and	CC
cord-022594-fx044gcd	976	36	a	a	DT
cord-022594-fx044gcd	976	37	post	post	JJ
cord-022594-fx044gcd	976	38	-	-	JJ
cord-022594-fx044gcd	976	39	void	void	JJ
cord-022594-fx044gcd	976	40	residual	residual	JJ
cord-022594-fx044gcd	976	41	urine	urine	NN
cord-022594-fx044gcd	976	42	measurement	measurement	NN
cord-022594-fx044gcd	976	43	.	.	.
cord-022594-fx044gcd	977	1	Residuals	residual	NNS
cord-022594-fx044gcd	977	2	in	in	IN
cord-022594-fx044gcd	977	3	excess	excess	NN
cord-022594-fx044gcd	977	4	of	of	IN
cord-022594-fx044gcd	977	5	15	15	CD
cord-022594-fx044gcd	977	6	mL	ml	NN
cord-022594-fx044gcd	977	7	are	be	VBP
cord-022594-fx044gcd	977	8	abnormal	abnormal	JJ
cord-022594-fx044gcd	977	9	;	;	:
cord-022594-fx044gcd	977	10	and	and	CC
cord-022594-fx044gcd	977	11	if	if	IN
cord-022594-fx044gcd	977	12	they	-PRON-	PRP
cord-022594-fx044gcd	977	13	are	be	VBP
cord-022594-fx044gcd	977	14	above	above	IN
cord-022594-fx044gcd	977	15	50	50	CD
cord-022594-fx044gcd	977	16	mL	ml	NN
cord-022594-fx044gcd	977	17	,	,	,
cord-022594-fx044gcd	977	18	consideration	consideration	NN
cord-022594-fx044gcd	977	19	should	should	MD
cord-022594-fx044gcd	977	20	be	be	VB
cord-022594-fx044gcd	977	21	given	give	VBN
cord-022594-fx044gcd	977	22	to	to	IN
cord-022594-fx044gcd	977	23	urological	urological	JJ
cord-022594-fx044gcd	977	24	consultation	consultation	NN
cord-022594-fx044gcd	977	25	for	for	IN
cord-022594-fx044gcd	977	26	more	more	RBR
cord-022594-fx044gcd	977	27	thorough	thorough	JJ
cord-022594-fx044gcd	977	28	investigation	investigation	NN
cord-022594-fx044gcd	977	29	and	and	CC
cord-022594-fx044gcd	977	30	to	to	IN
cord-022594-fx044gcd	977	31	blood	blood	NN
cord-022594-fx044gcd	977	32	chemistries	chemistry	NNS
cord-022594-fx044gcd	977	33	to	to	TO
cord-022594-fx044gcd	977	34	determine	determine	VB
cord-022594-fx044gcd	977	35	urea	urea	NN
cord-022594-fx044gcd	977	36	and	and	CC
cord-022594-fx044gcd	977	37	creatinine	creatinine	NN
cord-022594-fx044gcd	977	38	levels	level	NNS
cord-022594-fx044gcd	977	39	.	.	.
cord-022594-fx044gcd	978	1	Detrusor	Detrusor	NNP
cord-022594-fx044gcd	978	2	-	-	HYPH
cord-022594-fx044gcd	978	3	sphincter	sphincter	NN
cord-022594-fx044gcd	978	4	dyssynergia	dyssynergia	NN
cord-022594-fx044gcd	978	5	,	,	,
cord-022594-fx044gcd	978	6	diagnosed	diagnose	VBN
cord-022594-fx044gcd	978	7	by	by	IN
cord-022594-fx044gcd	978	8	cystometrography	cystometrography	NN
cord-022594-fx044gcd	978	9	,	,	,
cord-022594-fx044gcd	978	10	is	be	VBZ
cord-022594-fx044gcd	978	11	treated	treat	VBN
cord-022594-fx044gcd	978	12	with	with	IN
cord-022594-fx044gcd	978	13	anticholinergics	anticholinergic	NNS
cord-022594-fx044gcd	978	14	,	,	,
cord-022594-fx044gcd	978	15	sometimes	sometimes	RB
cord-022594-fx044gcd	978	16	with	with	IN
cord-022594-fx044gcd	978	17	the	the	DT
cord-022594-fx044gcd	978	18	addition	addition	NN
cord-022594-fx044gcd	978	19	of	of	IN
cord-022594-fx044gcd	978	20	an	an	DT
cord-022594-fx044gcd	978	21	a-1	a-1	NNP
cord-022594-fx044gcd	978	22	blocking	block	VBG
cord-022594-fx044gcd	978	23	agent	agent	NN
cord-022594-fx044gcd	978	24	(	(	-LRB-
cord-022594-fx044gcd	978	25	terazosin	terazosin	NNP
cord-022594-fx044gcd	978	26	)	)	-RRB-
cord-022594-fx044gcd	978	27	or	or	CC
cord-022594-fx044gcd	978	28	intermittent	intermittent	JJ
cord-022594-fx044gcd	978	29	catheterization	catheterization	NN
cord-022594-fx044gcd	978	30	.	.	.
cord-022594-fx044gcd	979	1	It	-PRON-	PRP
cord-022594-fx044gcd	979	2	is	be	VBZ
cord-022594-fx044gcd	979	3	important	important	JJ
cord-022594-fx044gcd	979	4	to	to	TO
cord-022594-fx044gcd	979	5	reassess	reassess	VB
cord-022594-fx044gcd	979	6	bladder	bladder	NN
cord-022594-fx044gcd	979	7	function	function	NN
cord-022594-fx044gcd	979	8	periodically	periodically	RB
cord-022594-fx044gcd	979	9	,	,	,
cord-022594-fx044gcd	979	10	and	and	CC
cord-022594-fx044gcd	979	11	residual	residual	JJ
cord-022594-fx044gcd	979	12	urine	urine	NN
cord-022594-fx044gcd	979	13	volumes	volume	NNS
cord-022594-fx044gcd	979	14	should	should	MD
cord-022594-fx044gcd	979	15	be	be	VB
cord-022594-fx044gcd	979	16	monitored	monitor	VBN
cord-022594-fx044gcd	979	17	if	if	IN
cord-022594-fx044gcd	979	18	there	there	EX
cord-022594-fx044gcd	979	19	are	be	VBP
cord-022594-fx044gcd	979	20	any	any	DT
cord-022594-fx044gcd	979	21	persistent	persistent	JJ
cord-022594-fx044gcd	979	22	changes	change	NNS
cord-022594-fx044gcd	979	23	in	in	IN
cord-022594-fx044gcd	979	24	function	function	NN
cord-022594-fx044gcd	979	25	or	or	CC
cord-022594-fx044gcd	979	26	symptoms	symptom	NNS
cord-022594-fx044gcd	979	27	.	.	.
cord-022594-fx044gcd	980	1	Intermittent	intermittent	JJ
cord-022594-fx044gcd	980	2	catheterization	catheterization	NN
cord-022594-fx044gcd	980	3	should	should	MD
cord-022594-fx044gcd	980	4	be	be	VB
cord-022594-fx044gcd	980	5	considered	consider	VBN
cord-022594-fx044gcd	980	6	when	when	WRB
cord-022594-fx044gcd	980	7	post	post	JJ
cord-022594-fx044gcd	980	8	-	-	JJ
cord-022594-fx044gcd	980	9	void	void	JJ
cord-022594-fx044gcd	980	10	residuals	residual	NNS
cord-022594-fx044gcd	980	11	reach	reach	VBP
cord-022594-fx044gcd	980	12	100	100	CD
cord-022594-fx044gcd	980	13	mL.	mL.	NNS
cord-022594-fx044gcd	980	14	A	a	DT
cord-022594-fx044gcd	980	15	chronic	chronic	JJ
cord-022594-fx044gcd	980	16	indwelling	indwell	VBG
cord-022594-fx044gcd	980	17	urinary	urinary	JJ
cord-022594-fx044gcd	980	18	catheter	catheter	NN
cord-022594-fx044gcd	980	19	should	should	MD
cord-022594-fx044gcd	980	20	be	be	VB
cord-022594-fx044gcd	980	21	avoided	avoid	VBN
cord-022594-fx044gcd	980	22	if	if	IN
cord-022594-fx044gcd	980	23	reasonably	reasonably	RB
cord-022594-fx044gcd	980	24	possible	possible	JJ
cord-022594-fx044gcd	980	25	.	.	.
cord-022594-fx044gcd	981	1	It	-PRON-	PRP
cord-022594-fx044gcd	981	2	is	be	VBZ
cord-022594-fx044gcd	981	3	usually	usually	RB
cord-022594-fx044gcd	981	4	not	not	RB
cord-022594-fx044gcd	981	5	necessary	necessary	JJ
cord-022594-fx044gcd	981	6	to	to	TO
cord-022594-fx044gcd	981	7	use	use	VB
cord-022594-fx044gcd	981	8	antibiotics	antibiotic	NNS
cord-022594-fx044gcd	981	9	prophylactically	prophylactically	RB
cord-022594-fx044gcd	981	10	in	in	IN
cord-022594-fx044gcd	981	11	the	the	DT
cord-022594-fx044gcd	981	12	prevention	prevention	NN
cord-022594-fx044gcd	981	13	of	of	IN
cord-022594-fx044gcd	981	14	urinary	urinary	JJ
cord-022594-fx044gcd	981	15	tract	tract	JJ
cord-022594-fx044gcd	981	16	infections	infection	NNS
cord-022594-fx044gcd	981	17	.	.	.
cord-022594-fx044gcd	982	1	Urinary	urinary	JJ
cord-022594-fx044gcd	982	2	calculi	calculus	NNS
cord-022594-fx044gcd	982	3	may	may	MD
cord-022594-fx044gcd	982	4	be	be	VB
cord-022594-fx044gcd	982	5	prevented	prevent	VBN
cord-022594-fx044gcd	982	6	by	by	IN
cord-022594-fx044gcd	982	7	acidification	acidification	NN
cord-022594-fx044gcd	982	8	of	of	IN
cord-022594-fx044gcd	982	9	the	the	DT
cord-022594-fx044gcd	982	10	urine	urine	NN
cord-022594-fx044gcd	982	11	with	with	IN
cord-022594-fx044gcd	982	12	cranberry	cranberry	NN
cord-022594-fx044gcd	982	13	juice	juice	NN
cord-022594-fx044gcd	982	14	.	.	.
cord-022594-fx044gcd	983	1	Bowel	Bowel	NNP
cord-022594-fx044gcd	983	2	Dysfunction	Dysfunction	NNP
cord-022594-fx044gcd	983	3	in	in	IN
cord-022594-fx044gcd	983	4	MS	MS	NNP
cord-022594-fx044gcd	983	5	.	.	.
cord-022594-fx044gcd	984	1	Constipation	constipation	NN
cord-022594-fx044gcd	984	2	can	can	MD
cord-022594-fx044gcd	984	3	usually	usually	RB
cord-022594-fx044gcd	984	4	be	be	VB
cord-022594-fx044gcd	984	5	managed	manage	VBN
cord-022594-fx044gcd	984	6	with	with	IN
cord-022594-fx044gcd	984	7	bulk	bulk	JJ
cord-022594-fx044gcd	984	8	laxatives	laxative	NNS
cord-022594-fx044gcd	984	9	and	and	CC
cord-022594-fx044gcd	984	10	stool	stool	NN
cord-022594-fx044gcd	984	11	softeners	softener	NNS
cord-022594-fx044gcd	984	12	.	.	.
cord-022594-fx044gcd	985	1	More	More	JJR
cord-022594-fx044gcd	985	2	severe	severe	JJ
cord-022594-fx044gcd	985	3	cases	case	NNS
cord-022594-fx044gcd	985	4	may	may	MD
cord-022594-fx044gcd	985	5	require	require	VB
cord-022594-fx044gcd	985	6	osmotic	osmotic	JJ
cord-022594-fx044gcd	985	7	agents	agent	NNS
cord-022594-fx044gcd	985	8	,	,	,
cord-022594-fx044gcd	985	9	bowel	bowel	NN
cord-022594-fx044gcd	985	10	stimulants	stimulant	NNS
cord-022594-fx044gcd	985	11	,	,	,
cord-022594-fx044gcd	985	12	anal	anal	JJ
cord-022594-fx044gcd	985	13	stimulation	stimulation	NN
cord-022594-fx044gcd	985	14	,	,	,
cord-022594-fx044gcd	985	15	suppositories	suppository	NNS
cord-022594-fx044gcd	985	16	,	,	,
cord-022594-fx044gcd	985	17	or	or	CC
cord-022594-fx044gcd	985	18	enemas	enema	NNS
cord-022594-fx044gcd	985	19	.	.	.
cord-022594-fx044gcd	986	1	Bedridden	bedridden	JJ
cord-022594-fx044gcd	986	2	patients	patient	NNS
cord-022594-fx044gcd	986	3	may	may	MD
cord-022594-fx044gcd	986	4	develop	develop	VB
cord-022594-fx044gcd	986	5	fecal	fecal	JJ
cord-022594-fx044gcd	986	6	impaction	impaction	NN
cord-022594-fx044gcd	986	7	unresponsive	unresponsive	JJ
cord-022594-fx044gcd	986	8	to	to	IN
cord-022594-fx044gcd	986	9	these	these	DT
cord-022594-fx044gcd	986	10	measures	measure	NNS
cord-022594-fx044gcd	986	11	and	and	CC
cord-022594-fx044gcd	986	12	require	require	VB
cord-022594-fx044gcd	986	13	manual	manual	JJ
cord-022594-fx044gcd	986	14	disimpaction	disimpaction	NN
cord-022594-fx044gcd	986	15	.	.	.
cord-022594-fx044gcd	987	1	Fecal	fecal	JJ
cord-022594-fx044gcd	987	2	incontinence	incontinence	NN
cord-022594-fx044gcd	987	3	can	can	MD
cord-022594-fx044gcd	987	4	be	be	VB
cord-022594-fx044gcd	987	5	minimized	minimize	VBN
cord-022594-fx044gcd	987	6	by	by	IN
cord-022594-fx044gcd	987	7	adherence	adherence	NN
cord-022594-fx044gcd	987	8	to	to	IN
cord-022594-fx044gcd	987	9	a	a	DT
cord-022594-fx044gcd	987	10	schedule	schedule	NN
cord-022594-fx044gcd	987	11	for	for	IN
cord-022594-fx044gcd	987	12	bowel	bowel	NN
cord-022594-fx044gcd	987	13	movements	movement	NNS
cord-022594-fx044gcd	987	14	.	.	.
cord-022594-fx044gcd	988	1	Fiber	fiber	NN
cord-022594-fx044gcd	988	2	supplementation	supplementation	NN
cord-022594-fx044gcd	988	3	may	may	MD
cord-022594-fx044gcd	988	4	be	be	VB
cord-022594-fx044gcd	988	5	of	of	IN
cord-022594-fx044gcd	988	6	some	some	DT
cord-022594-fx044gcd	988	7	benefit	benefit	NN
cord-022594-fx044gcd	988	8	even	even	RB
cord-022594-fx044gcd	988	9	in	in	IN
cord-022594-fx044gcd	988	10	these	these	DT
cord-022594-fx044gcd	988	11	cases	case	NNS
cord-022594-fx044gcd	988	12	.	.	.
cord-022594-fx044gcd	989	1	Sexual	Sexual	NNP
cord-022594-fx044gcd	989	2	Dysfunction	Dysfunction	NNP
cord-022594-fx044gcd	989	3	in	in	IN
cord-022594-fx044gcd	989	4	MS	MS	NNP
cord-022594-fx044gcd	989	5	.	.	.
cord-022594-fx044gcd	990	1	The	the	DT
cord-022594-fx044gcd	990	2	clinician	clinician	NN
cord-022594-fx044gcd	990	3	should	should	MD
cord-022594-fx044gcd	990	4	determine	determine	VB
cord-022594-fx044gcd	990	5	the	the	DT
cord-022594-fx044gcd	990	6	precise	precise	JJ
cord-022594-fx044gcd	990	7	nature	nature	NN
cord-022594-fx044gcd	990	8	of	of	IN
cord-022594-fx044gcd	990	9	any	any	DT
cord-022594-fx044gcd	990	10	sexual	sexual	JJ
cord-022594-fx044gcd	990	11	dysfunction	dysfunction	NN
cord-022594-fx044gcd	990	12	in	in	IN
cord-022594-fx044gcd	990	13	patients	patient	NNS
cord-022594-fx044gcd	990	14	with	with	IN
cord-022594-fx044gcd	990	15	MS	MS	NNP
cord-022594-fx044gcd	990	16	.	.	.
cord-022594-fx044gcd	991	1	Physical	physical	JJ
cord-022594-fx044gcd	991	2	difficulty	difficulty	NN
cord-022594-fx044gcd	991	3	from	from	IN
cord-022594-fx044gcd	991	4	spasticity	spasticity	NN
cord-022594-fx044gcd	991	5	may	may	MD
cord-022594-fx044gcd	991	6	be	be	VB
cord-022594-fx044gcd	991	7	alleviated	alleviate	VBN
cord-022594-fx044gcd	991	8	by	by	IN
cord-022594-fx044gcd	991	9	premedication	premedication	NN
cord-022594-fx044gcd	991	10	with	with	IN
cord-022594-fx044gcd	991	11	baclofen	baclofen	NN
cord-022594-fx044gcd	991	12	,	,	,
cord-022594-fx044gcd	991	13	and	and	CC
cord-022594-fx044gcd	991	14	a	a	DT
cord-022594-fx044gcd	991	15	fast	fast	RB
cord-022594-fx044gcd	991	16	-	-	HYPH
cord-022594-fx044gcd	991	17	acting	act	VBG
cord-022594-fx044gcd	991	18	anticholinergic	anticholinergic	JJ
cord-022594-fx044gcd	991	19	such	such	JJ
cord-022594-fx044gcd	991	20	as	as	IN
cord-022594-fx044gcd	991	21	oxybutynin	oxybutynin	NNS
cord-022594-fx044gcd	991	22	may	may	MD
cord-022594-fx044gcd	991	23	calm	calm	VB
cord-022594-fx044gcd	991	24	urinary	urinary	JJ
cord-022594-fx044gcd	991	25	urgency	urgency	NN
cord-022594-fx044gcd	991	26	.	.	.
cord-022594-fx044gcd	992	1	Sexual	sexual	JJ
cord-022594-fx044gcd	992	2	dysfunction	dysfunction	NN
cord-022594-fx044gcd	992	3	should	should	MD
cord-022594-fx044gcd	992	4	not	not	RB
cord-022594-fx044gcd	992	5	be	be	VB
cord-022594-fx044gcd	992	6	automatically	automatically	RB
cord-022594-fx044gcd	992	7	attributed	attribute	VBN
cord-022594-fx044gcd	992	8	to	to	IN
cord-022594-fx044gcd	992	9	MS	MS	NNP
cord-022594-fx044gcd	992	10	.	.	.
cord-022594-fx044gcd	993	1	It	-PRON-	PRP
cord-022594-fx044gcd	993	2	may	may	MD
cord-022594-fx044gcd	993	3	be	be	VB
cord-022594-fx044gcd	993	4	necessary	necessary	JJ
cord-022594-fx044gcd	993	5	to	to	TO
cord-022594-fx044gcd	993	6	investigate	investigate	VB
cord-022594-fx044gcd	993	7	hormonal	hormonal	JJ
cord-022594-fx044gcd	993	8	levels	level	NNS
cord-022594-fx044gcd	993	9	and	and	CC
cord-022594-fx044gcd	993	10	to	to	TO
cord-022594-fx044gcd	993	11	obtain	obtain	VB
cord-022594-fx044gcd	993	12	urological	urological	JJ
cord-022594-fx044gcd	993	13	or	or	CC
cord-022594-fx044gcd	993	14	gynecological	gynecological	JJ
cord-022594-fx044gcd	993	15	consultation	consultation	NN
cord-022594-fx044gcd	993	16	.	.	.
cord-022594-fx044gcd	994	1	Manual	manual	JJ
cord-022594-fx044gcd	994	2	lubrication	lubrication	NN
cord-022594-fx044gcd	994	3	with	with	IN
cord-022594-fx044gcd	994	4	gel	gel	NN
cord-022594-fx044gcd	994	5	is	be	VBZ
cord-022594-fx044gcd	994	6	a	a	DT
cord-022594-fx044gcd	994	7	ready	ready	JJ
cord-022594-fx044gcd	994	8	solution	solution	NN
cord-022594-fx044gcd	994	9	to	to	IN
cord-022594-fx044gcd	994	10	vaginal	vaginal	JJ
cord-022594-fx044gcd	994	11	dryness	dryness	NN
cord-022594-fx044gcd	994	12	.	.	.
cord-022594-fx044gcd	995	1	Erectile	erectile	NN
cord-022594-fx044gcd	995	2	dysfunction	dysfunction	NN
cord-022594-fx044gcd	995	3	responds	respond	VBZ
cord-022594-fx044gcd	995	4	very	very	RB
cord-022594-fx044gcd	995	5	well	well	RB
cord-022594-fx044gcd	995	6	to	to	IN
cord-022594-fx044gcd	995	7	sildenafil	sildenafil	NNP
cord-022594-fx044gcd	995	8	.	.	.
cord-022594-fx044gcd	996	1	Less	less	RBR
cord-022594-fx044gcd	996	2	frequently	frequently	RB
cord-022594-fx044gcd	996	3	,	,	,
cord-022594-fx044gcd	996	4	vacuum	vacuum	NN
cord-022594-fx044gcd	996	5	devices	device	NNS
cord-022594-fx044gcd	996	6	,	,	,
cord-022594-fx044gcd	996	7	intracavernous	intracavernous	JJ
cord-022594-fx044gcd	996	8	injections	injection	NNS
cord-022594-fx044gcd	996	9	of	of	IN
cord-022594-fx044gcd	996	10	papaverine	papaverine	NN
cord-022594-fx044gcd	996	11	(	(	-LRB-
cord-022594-fx044gcd	996	12	or	or	CC
cord-022594-fx044gcd	996	13	combinations	combination	NNS
cord-022594-fx044gcd	996	14	of	of	IN
cord-022594-fx044gcd	996	15	papaverine	papaverine	NN
cord-022594-fx044gcd	996	16	,	,	,
cord-022594-fx044gcd	996	17	prostaglandins	prostaglandin	NNS
cord-022594-fx044gcd	996	18	,	,	,
cord-022594-fx044gcd	996	19	and	and	CC
cord-022594-fx044gcd	996	20	epinephrine	epinephrine	NN
cord-022594-fx044gcd	996	21	;	;	:
cord-022594-fx044gcd	996	22	triple	triple	JJ
cord-022594-fx044gcd	996	23	agent	agent	NN
cord-022594-fx044gcd	996	24	)	)	-RRB-
cord-022594-fx044gcd	996	25	,	,	,
cord-022594-fx044gcd	996	26	or	or	CC
cord-022594-fx044gcd	996	27	penile	penile	JJ
cord-022594-fx044gcd	996	28	implant	implant	NN
cord-022594-fx044gcd	996	29	are	be	VBP
cord-022594-fx044gcd	996	30	also	also	RB
cord-022594-fx044gcd	996	31	used	use	VBN
cord-022594-fx044gcd	996	32	in	in	IN
cord-022594-fx044gcd	996	33	the	the	DT
cord-022594-fx044gcd	996	34	treatment	treatment	NN
cord-022594-fx044gcd	996	35	of	of	IN
cord-022594-fx044gcd	996	36	erectile	erectile	NN
cord-022594-fx044gcd	996	37	dysfunction	dysfunction	NN
cord-022594-fx044gcd	996	38	.	.	.
cord-022594-fx044gcd	997	1	Thalamotomy	Thalamotomy	NNP
cord-022594-fx044gcd	997	2	or	or	CC
cord-022594-fx044gcd	997	3	thalamic	thalamic	JJ
cord-022594-fx044gcd	997	4	stimulation	stimulation	NN
cord-022594-fx044gcd	997	5	may	may	MD
cord-022594-fx044gcd	997	6	provide	provide	VB
cord-022594-fx044gcd	997	7	some	some	DT
cord-022594-fx044gcd	997	8	short	short	JJ
cord-022594-fx044gcd	997	9	-	-	HYPH
cord-022594-fx044gcd	997	10	term	term	NN
cord-022594-fx044gcd	997	11	clinical	clinical	JJ
cord-022594-fx044gcd	997	12	benefit	benefit	NN
cord-022594-fx044gcd	997	13	to	to	IN
cord-022594-fx044gcd	997	14	patients	patient	NNS
cord-022594-fx044gcd	997	15	disabled	disable	VBN
cord-022594-fx044gcd	997	16	by	by	IN
cord-022594-fx044gcd	997	17	appendicular	appendicular	JJ
cord-022594-fx044gcd	997	18	cerebellar	cerebellar	JJ
cord-022594-fx044gcd	997	19	tremor	tremor	NN
cord-022594-fx044gcd	997	20	and	and	CC
cord-022594-fx044gcd	997	21	ataxia	ataxia	NN
cord-022594-fx044gcd	997	22	.	.	.
cord-022594-fx044gcd	998	1	The	the	DT
cord-022594-fx044gcd	998	2	benefits	benefit	NNS
cord-022594-fx044gcd	998	3	on	on	IN
cord-022594-fx044gcd	998	4	disability	disability	NN
cord-022594-fx044gcd	998	5	and	and	CC
cord-022594-fx044gcd	998	6	quality	quality	NN
cord-022594-fx044gcd	998	7	of	of	IN
cord-022594-fx044gcd	998	8	life	life	NN
cord-022594-fx044gcd	998	9	are	be	VBP
cord-022594-fx044gcd	998	10	much	much	RB
cord-022594-fx044gcd	998	11	less	less	RBR
cord-022594-fx044gcd	998	12	clear	clear	JJ
cord-022594-fx044gcd	998	13	,	,	,
cord-022594-fx044gcd	998	14	however	however	RB
cord-022594-fx044gcd	998	15	,	,	,
cord-022594-fx044gcd	998	16	and	and	CC
cord-022594-fx044gcd	998	17	the	the	DT
cord-022594-fx044gcd	998	18	early	early	JJ
cord-022594-fx044gcd	998	19	benefits	benefit	NNS
cord-022594-fx044gcd	998	20	may	may	MD
cord-022594-fx044gcd	998	21	wain	wain	VB
cord-022594-fx044gcd	998	22	within	within	IN
cord-022594-fx044gcd	998	23	1	1	CD
cord-022594-fx044gcd	998	24	to	to	IN
cord-022594-fx044gcd	998	25	3	3	CD
cord-022594-fx044gcd	998	26	years	year	NNS
cord-022594-fx044gcd	998	27	.	.	.
cord-022594-fx044gcd	999	1	109	109	CD
cord-022594-fx044gcd	999	2	,	,	,
cord-022594-fx044gcd	999	3	110	110	CD
cord-022594-fx044gcd	999	4	Further	further	JJ
cord-022594-fx044gcd	999	5	studies	study	NNS
cord-022594-fx044gcd	999	6	are	be	VBP
cord-022594-fx044gcd	999	7	needed	need	VBN
cord-022594-fx044gcd	999	8	to	to	TO
cord-022594-fx044gcd	999	9	clarify	clarify	VB
cord-022594-fx044gcd	999	10	how	how	WRB
cord-022594-fx044gcd	999	11	best	good	JJS
cord-022594-fx044gcd	999	12	to	to	TO
cord-022594-fx044gcd	999	13	select	select	VB
cord-022594-fx044gcd	999	14	patients	patient	NNS
cord-022594-fx044gcd	999	15	for	for	IN
cord-022594-fx044gcd	999	16	these	these	DT
cord-022594-fx044gcd	999	17	ablative	ablative	JJ
cord-022594-fx044gcd	999	18	and	and	CC
cord-022594-fx044gcd	999	19	stimulation	stimulation	NN
cord-022594-fx044gcd	999	20	treatment	treatment	NN
cord-022594-fx044gcd	999	21	interventions	intervention	NNS
cord-022594-fx044gcd	999	22	.	.	.
cord-022594-fx044gcd	1000	1	General	General	NNP
cord-022594-fx044gcd	1000	2	Recommendations	Recommendations	NNPS
cord-022594-fx044gcd	1000	3	for	for	IN
cord-022594-fx044gcd	1000	4	MS	MS	NNP
cord-022594-fx044gcd	1000	5	Patients	Patients	NNP
cord-022594-fx044gcd	1000	6	.	.	.
cord-022594-fx044gcd	1001	1	It	-PRON-	PRP
cord-022594-fx044gcd	1001	2	is	be	VBZ
cord-022594-fx044gcd	1001	3	advisable	advisable	JJ
cord-022594-fx044gcd	1001	4	for	for	IN
cord-022594-fx044gcd	1001	5	MS	MS	NNP
cord-022594-fx044gcd	1001	6	patients	patient	NNS
cord-022594-fx044gcd	1001	7	to	to	TO
cord-022594-fx044gcd	1001	8	attain	attain	VB
cord-022594-fx044gcd	1001	9	good	good	JJ
cord-022594-fx044gcd	1001	10	health	health	NN
cord-022594-fx044gcd	1001	11	habits	habit	NNS
cord-022594-fx044gcd	1001	12	,	,	,
cord-022594-fx044gcd	1001	13	including	include	VBG
cord-022594-fx044gcd	1001	14	proper	proper	JJ
cord-022594-fx044gcd	1001	15	diet	diet	NN
cord-022594-fx044gcd	1001	16	and	and	CC
cord-022594-fx044gcd	1001	17	fitness	fitness	NN
cord-022594-fx044gcd	1001	18	.	.	.
cord-022594-fx044gcd	1002	1	Smoking	smoking	NN
cord-022594-fx044gcd	1002	2	,	,	,
cord-022594-fx044gcd	1002	3	excess	excess	JJ
cord-022594-fx044gcd	1002	4	alcohol	alcohol	NN
cord-022594-fx044gcd	1002	5	intake	intake	NN
cord-022594-fx044gcd	1002	6	,	,	,
cord-022594-fx044gcd	1002	7	and	and	CC
cord-022594-fx044gcd	1002	8	obesity	obesity	NN
cord-022594-fx044gcd	1002	9	should	should	MD
cord-022594-fx044gcd	1002	10	be	be	VB
cord-022594-fx044gcd	1002	11	avoided	avoid	VBN
cord-022594-fx044gcd	1002	12	.	.	.
cord-022594-fx044gcd	1003	1	Exercise	exercise	NN
cord-022594-fx044gcd	1003	2	can	can	MD
cord-022594-fx044gcd	1003	3	help	help	VB
cord-022594-fx044gcd	1003	4	maximize	maximize	VB
cord-022594-fx044gcd	1003	5	function	function	NN
cord-022594-fx044gcd	1003	6	by	by	IN
cord-022594-fx044gcd	1003	7	increasing	increase	VBG
cord-022594-fx044gcd	1003	8	and	and	CC
cord-022594-fx044gcd	1003	9	maintaining	maintain	VBG
cord-022594-fx044gcd	1003	10	joint	joint	JJ
cord-022594-fx044gcd	1003	11	mobility	mobility	NN
cord-022594-fx044gcd	1003	12	,	,	,
cord-022594-fx044gcd	1003	13	strength	strength	NN
cord-022594-fx044gcd	1003	14	,	,	,
cord-022594-fx044gcd	1003	15	and	and	CC
cord-022594-fx044gcd	1003	16	stamina	stamina	NN
cord-022594-fx044gcd	1003	17	;	;	:
cord-022594-fx044gcd	1003	18	may	may	MD
cord-022594-fx044gcd	1003	19	promote	promote	VB
cord-022594-fx044gcd	1003	20	improved	improved	JJ
cord-022594-fx044gcd	1003	21	sleep	sleep	NN
cord-022594-fx044gcd	1003	22	hygiene	hygiene	NN
cord-022594-fx044gcd	1003	23	;	;	:
cord-022594-fx044gcd	1003	24	and	and	CC
cord-022594-fx044gcd	1003	25	may	may	MD
cord-022594-fx044gcd	1003	26	reduce	reduce	VB
cord-022594-fx044gcd	1003	27	the	the	DT
cord-022594-fx044gcd	1003	28	severity	severity	NN
cord-022594-fx044gcd	1003	29	of	of	IN
cord-022594-fx044gcd	1003	30	fatigue	fatigue	NN
cord-022594-fx044gcd	1003	31	.	.	.
cord-022594-fx044gcd	1004	1	Physical	physical	JJ
cord-022594-fx044gcd	1004	2	and	and	CC
cord-022594-fx044gcd	1004	3	occupational	occupational	JJ
cord-022594-fx044gcd	1004	4	therapy	therapy	NN
cord-022594-fx044gcd	1004	5	can	can	MD
cord-022594-fx044gcd	1004	6	play	play	VB
cord-022594-fx044gcd	1004	7	an	an	DT
cord-022594-fx044gcd	1004	8	important	important	JJ
cord-022594-fx044gcd	1004	9	role	role	NN
cord-022594-fx044gcd	1004	10	in	in	IN
cord-022594-fx044gcd	1004	11	regaining	regain	VBG
cord-022594-fx044gcd	1004	12	independence	independence	NN
cord-022594-fx044gcd	1004	13	.	.	.
cord-022594-fx044gcd	1005	1	Canes	cane	NNS
cord-022594-fx044gcd	1005	2	,	,	,
cord-022594-fx044gcd	1005	3	walkers	walker	NNS
cord-022594-fx044gcd	1005	4	,	,	,
cord-022594-fx044gcd	1005	5	and	and	CC
cord-022594-fx044gcd	1005	6	wheelchairs	wheelchair	NNS
cord-022594-fx044gcd	1005	7	or	or	CC
cord-022594-fx044gcd	1005	8	scooters	scooter	NNS
cord-022594-fx044gcd	1005	9	may	may	MD
cord-022594-fx044gcd	1005	10	be	be	VB
cord-022594-fx044gcd	1005	11	needed	need	VBN
cord-022594-fx044gcd	1005	12	to	to	TO
cord-022594-fx044gcd	1005	13	maintain	maintain	VB
cord-022594-fx044gcd	1005	14	safe	safe	JJ
cord-022594-fx044gcd	1005	15	mobility	mobility	NN
cord-022594-fx044gcd	1005	16	.	.	.
cord-022594-fx044gcd	1006	1	Hand	hand	NN
cord-022594-fx044gcd	1006	2	controls	control	NNS
cord-022594-fx044gcd	1006	3	can	can	MD
cord-022594-fx044gcd	1006	4	be	be	VB
cord-022594-fx044gcd	1006	5	installed	instal	VBN
cord-022594-fx044gcd	1006	6	in	in	IN
cord-022594-fx044gcd	1006	7	automobiles	automobile	NNS
cord-022594-fx044gcd	1006	8	for	for	IN
cord-022594-fx044gcd	1006	9	patients	patient	NNS
cord-022594-fx044gcd	1006	10	with	with	IN
cord-022594-fx044gcd	1006	11	lower	low	JJR
cord-022594-fx044gcd	1006	12	extremity	extremity	NN
cord-022594-fx044gcd	1006	13	dysfunction	dysfunction	NN
cord-022594-fx044gcd	1006	14	.	.	.
cord-022594-fx044gcd	1007	1	In	in	IN
cord-022594-fx044gcd	1007	2	debilitated	debilitated	JJ
cord-022594-fx044gcd	1007	3	,	,	,
cord-022594-fx044gcd	1007	4	immobilized	immobilize	VBN
cord-022594-fx044gcd	1007	5	patients	patient	NNS
cord-022594-fx044gcd	1007	6	,	,	,
cord-022594-fx044gcd	1007	7	periodic	periodic	JJ
cord-022594-fx044gcd	1007	8	shifts	shift	NNS
cord-022594-fx044gcd	1007	9	in	in	IN
cord-022594-fx044gcd	1007	10	posture	posture	NN
cord-022594-fx044gcd	1007	11	to	to	TO
cord-022594-fx044gcd	1007	12	change	change	VB
cord-022594-fx044gcd	1007	13	weight	weight	NN
cord-022594-fx044gcd	1007	14	-	-	HYPH
cord-022594-fx044gcd	1007	15	bearing	bear	VBG
cord-022594-fx044gcd	1007	16	regions	region	NNS
cord-022594-fx044gcd	1007	17	and	and	CC
cord-022594-fx044gcd	1007	18	air	air	NN
cord-022594-fx044gcd	1007	19	or	or	CC
cord-022594-fx044gcd	1007	20	water	water	NN
cord-022594-fx044gcd	1007	21	mattresses	mattress	NNS
cord-022594-fx044gcd	1007	22	prevent	prevent	VBP
cord-022594-fx044gcd	1007	23	bedsores	bedsore	NNS
cord-022594-fx044gcd	1007	24	.	.	.
cord-022594-fx044gcd	1008	1	Passive	passive	JJ
cord-022594-fx044gcd	1008	2	range	range	NN
cord-022594-fx044gcd	1008	3	of	of	IN
cord-022594-fx044gcd	1008	4	motion	motion	NN
cord-022594-fx044gcd	1008	5	exercises	exercise	NNS
cord-022594-fx044gcd	1008	6	prevent	prevent	VBP
cord-022594-fx044gcd	1008	7	contractures	contracture	NNS
cord-022594-fx044gcd	1008	8	.	.	.
cord-022594-fx044gcd	1009	1	When	when	WRB
cord-022594-fx044gcd	1009	2	ventilatory	ventilatory	JJ
cord-022594-fx044gcd	1009	3	dysfunction	dysfunction	NN
cord-022594-fx044gcd	1009	4	occurs	occur	VBZ
cord-022594-fx044gcd	1009	5	,	,	,
cord-022594-fx044gcd	1009	6	it	-PRON-	PRP
cord-022594-fx044gcd	1009	7	should	should	MD
cord-022594-fx044gcd	1009	8	be	be	VB
cord-022594-fx044gcd	1009	9	evaluated	evaluate	VBN
cord-022594-fx044gcd	1009	10	and	and	CC
cord-022594-fx044gcd	1009	11	activity	activity	NN
cord-022594-fx044gcd	1009	12	schedules	schedule	NNS
cord-022594-fx044gcd	1009	13	should	should	MD
cord-022594-fx044gcd	1009	14	be	be	VB
cord-022594-fx044gcd	1009	15	appropriately	appropriately	RB
cord-022594-fx044gcd	1009	16	modified	modify	VBN
cord-022594-fx044gcd	1009	17	.	.	.
cord-022594-fx044gcd	1010	1	111	111	CD
cord-022594-fx044gcd	1010	2	Special	Special	NNP
cord-022594-fx044gcd	1010	3	Considerations	Considerations	NNPS
cord-022594-fx044gcd	1010	4	during	during	IN
cord-022594-fx044gcd	1010	5	Pregnancy	Pregnancy	NNP
cord-022594-fx044gcd	1010	6	.	.	.
cord-022594-fx044gcd	1011	1	Before	before	IN
cord-022594-fx044gcd	1011	2	initiation	initiation	NN
cord-022594-fx044gcd	1011	3	of	of	IN
cord-022594-fx044gcd	1011	4	any	any	DT
cord-022594-fx044gcd	1011	5	drug	drug	NN
cord-022594-fx044gcd	1011	6	in	in	IN
cord-022594-fx044gcd	1011	7	a	a	DT
cord-022594-fx044gcd	1011	8	woman	woman	NN
cord-022594-fx044gcd	1011	9	of	of	IN
cord-022594-fx044gcd	1011	10	reproductive	reproductive	JJ
cord-022594-fx044gcd	1011	11	age	age	NN
cord-022594-fx044gcd	1011	12	,	,	,
cord-022594-fx044gcd	1011	13	the	the	DT
cord-022594-fx044gcd	1011	14	potential	potential	NN
cord-022594-fx044gcd	1011	15	for	for	IN
cord-022594-fx044gcd	1011	16	teratogenicity	teratogenicity	NN
cord-022594-fx044gcd	1011	17	must	must	MD
cord-022594-fx044gcd	1011	18	be	be	VB
cord-022594-fx044gcd	1011	19	discussed	discuss	VBN
cord-022594-fx044gcd	1011	20	.	.	.
cord-022594-fx044gcd	1012	1	In	in	IN
cord-022594-fx044gcd	1012	2	general	general	JJ
cord-022594-fx044gcd	1012	3	,	,	,
cord-022594-fx044gcd	1012	4	immunomodulator	immunomodulator	NN
cord-022594-fx044gcd	1012	5	therapy	therapy	NN
cord-022594-fx044gcd	1012	6	should	should	MD
cord-022594-fx044gcd	1012	7	be	be	VB
cord-022594-fx044gcd	1012	8	avoided	avoid	VBN
cord-022594-fx044gcd	1012	9	if	if	IN
cord-022594-fx044gcd	1012	10	one	one	CD
cord-022594-fx044gcd	1012	11	is	be	VBZ
cord-022594-fx044gcd	1012	12	planning	plan	VBG
cord-022594-fx044gcd	1012	13	a	a	DT
cord-022594-fx044gcd	1012	14	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1012	15	.	.	.
cord-022594-fx044gcd	1013	1	The	the	DT
cord-022594-fx044gcd	1013	2	treatment	treatment	NN
cord-022594-fx044gcd	1013	3	of	of	IN
cord-022594-fx044gcd	1013	4	acute	acute	JJ
cord-022594-fx044gcd	1013	5	exacerbations	exacerbation	NNS
cord-022594-fx044gcd	1013	6	is	be	VBZ
cord-022594-fx044gcd	1013	7	unchanged	unchanged	JJ
cord-022594-fx044gcd	1013	8	during	during	IN
cord-022594-fx044gcd	1013	9	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1013	10	,	,	,
cord-022594-fx044gcd	1013	11	although	although	IN
cord-022594-fx044gcd	1013	12	one	one	PRP
cord-022594-fx044gcd	1013	13	might	may	MD
cord-022594-fx044gcd	1013	14	have	have	VB
cord-022594-fx044gcd	1013	15	a	a	DT
cord-022594-fx044gcd	1013	16	higher	high	JJR
cord-022594-fx044gcd	1013	17	threshold	threshold	NN
cord-022594-fx044gcd	1013	18	for	for	IN
cord-022594-fx044gcd	1013	19	treatment	treatment	NN
cord-022594-fx044gcd	1013	20	.	.	.
cord-022594-fx044gcd	1014	1	Both	both	DT
cord-022594-fx044gcd	1014	2	corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	1014	3	and	and	CC
cord-022594-fx044gcd	1014	4	plasma	plasma	NN
cord-022594-fx044gcd	1014	5	exchange	exchange	NN
cord-022594-fx044gcd	1014	6	are	be	VBP
cord-022594-fx044gcd	1014	7	relatively	relatively	RB
cord-022594-fx044gcd	1014	8	safe	safe	JJ
cord-022594-fx044gcd	1014	9	during	during	IN
cord-022594-fx044gcd	1014	10	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1014	11	.	.	.
cord-022594-fx044gcd	1015	1	None	none	NN
cord-022594-fx044gcd	1015	2	of	of	IN
cord-022594-fx044gcd	1015	3	the	the	DT
cord-022594-fx044gcd	1015	4	drugs	drug	NNS
cord-022594-fx044gcd	1015	5	used	use	VBN
cord-022594-fx044gcd	1015	6	to	to	TO
cord-022594-fx044gcd	1015	7	alter	alter	VB
cord-022594-fx044gcd	1015	8	the	the	DT
cord-022594-fx044gcd	1015	9	disease	disease	NN
cord-022594-fx044gcd	1015	10	course	course	NN
cord-022594-fx044gcd	1015	11	,	,	,
cord-022594-fx044gcd	1015	12	however	however	RB
cord-022594-fx044gcd	1015	13	,	,	,
cord-022594-fx044gcd	1015	14	should	should	MD
cord-022594-fx044gcd	1015	15	be	be	VB
cord-022594-fx044gcd	1015	16	used	use	VBN
cord-022594-fx044gcd	1015	17	during	during	IN
cord-022594-fx044gcd	1015	18	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1015	19	.	.	.
cord-022594-fx044gcd	1016	1	Interferon	interferon	NN
cord-022594-fx044gcd	1016	2	-	-	HYPH
cord-022594-fx044gcd	1016	3	b	b	NN
cord-022594-fx044gcd	1016	4	drugs	drug	NNS
cord-022594-fx044gcd	1016	5	should	should	MD
cord-022594-fx044gcd	1016	6	be	be	VB
cord-022594-fx044gcd	1016	7	stopped	stop	VBN
cord-022594-fx044gcd	1016	8	2	2	CD
cord-022594-fx044gcd	1016	9	to	to	TO
cord-022594-fx044gcd	1016	10	3	3	CD
cord-022594-fx044gcd	1016	11	months	month	NNS
cord-022594-fx044gcd	1016	12	before	before	IN
cord-022594-fx044gcd	1016	13	planning	plan	VBG
cord-022594-fx044gcd	1016	14	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1016	15	.	.	.
cord-022594-fx044gcd	1017	1	Interferons	interferon	NNS
cord-022594-fx044gcd	1017	2	are	be	VBP
cord-022594-fx044gcd	1017	3	associated	associate	VBN
cord-022594-fx044gcd	1017	4	with	with	IN
cord-022594-fx044gcd	1017	5	an	an	DT
cord-022594-fx044gcd	1017	6	approximately	approximately	RB
cord-022594-fx044gcd	1017	7	39	39	CD
cord-022594-fx044gcd	1017	8	%	%	NN
cord-022594-fx044gcd	1017	9	likelihood	likelihood	NN
cord-022594-fx044gcd	1017	10	of	of	IN
cord-022594-fx044gcd	1017	11	abortions	abortion	NNS
cord-022594-fx044gcd	1017	12	.	.	.
cord-022594-fx044gcd	1018	1	This	this	DT
cord-022594-fx044gcd	1018	2	is	be	VBZ
cord-022594-fx044gcd	1018	3	close	close	JJ
cord-022594-fx044gcd	1018	4	to	to	IN
cord-022594-fx044gcd	1018	5	eight	eight	CD
cord-022594-fx044gcd	1018	6	times	time	NNS
cord-022594-fx044gcd	1018	7	higher	high	JJR
cord-022594-fx044gcd	1018	8	than	than	IN
cord-022594-fx044gcd	1018	9	the	the	DT
cord-022594-fx044gcd	1018	10	usually	usually	RB
cord-022594-fx044gcd	1018	11	quoted	quote	VBN
cord-022594-fx044gcd	1018	12	approximately	approximately	RB
cord-022594-fx044gcd	1018	13	5	5	CD
cord-022594-fx044gcd	1018	14	%	%	NN
cord-022594-fx044gcd	1018	15	spontaneous	spontaneous	JJ
cord-022594-fx044gcd	1018	16	abortion	abortion	NN
cord-022594-fx044gcd	1018	17	rate	rate	NN
cord-022594-fx044gcd	1018	18	in	in	IN
cord-022594-fx044gcd	1018	19	women	woman	NNS
cord-022594-fx044gcd	1018	20	.	.	.
cord-022594-fx044gcd	1019	1	Interferon	interferon	NN
cord-022594-fx044gcd	1019	2	-	-	HYPH
cord-022594-fx044gcd	1019	3	b	b	NN
cord-022594-fx044gcd	1019	4	use	use	NN
cord-022594-fx044gcd	1019	5	is	be	VBZ
cord-022594-fx044gcd	1019	6	also	also	RB
cord-022594-fx044gcd	1019	7	associated	associate	VBN
cord-022594-fx044gcd	1019	8	with	with	IN
cord-022594-fx044gcd	1019	9	lower	low	JJR
cord-022594-fx044gcd	1019	10	birth	birth	NN
cord-022594-fx044gcd	1019	11	weight	weight	NN
cord-022594-fx044gcd	1019	12	.	.	.
cord-022594-fx044gcd	1020	1	112	112	CD
cord-022594-fx044gcd	1021	1	The	the	DT
cord-022594-fx044gcd	1021	2	cytotoxic	cytotoxic	JJ
cord-022594-fx044gcd	1021	3	immunosuppressants	immunosuppressant	NNS
cord-022594-fx044gcd	1021	4	have	have	VBP
cord-022594-fx044gcd	1021	5	teratogenic	teratogenic	JJ
cord-022594-fx044gcd	1021	6	effects	effect	NNS
cord-022594-fx044gcd	1021	7	.	.	.
cord-022594-fx044gcd	1022	1	The	the	DT
cord-022594-fx044gcd	1022	2	effects	effect	NNS
cord-022594-fx044gcd	1022	3	of	of	IN
cord-022594-fx044gcd	1022	4	many	many	JJ
cord-022594-fx044gcd	1022	5	of	of	IN
cord-022594-fx044gcd	1022	6	the	the	DT
cord-022594-fx044gcd	1022	7	other	other	JJ
cord-022594-fx044gcd	1022	8	drugs	drug	NNS
cord-022594-fx044gcd	1022	9	are	be	VBP
cord-022594-fx044gcd	1022	10	unknown	unknown	JJ
cord-022594-fx044gcd	1022	11	.	.	.
cord-022594-fx044gcd	1023	1	It	-PRON-	PRP
cord-022594-fx044gcd	1023	2	is	be	VBZ
cord-022594-fx044gcd	1023	3	best	good	JJS
cord-022594-fx044gcd	1023	4	if	if	IN
cord-022594-fx044gcd	1023	5	these	these	DT
cord-022594-fx044gcd	1023	6	drugs	drug	NNS
cord-022594-fx044gcd	1023	7	are	be	VBP
cord-022594-fx044gcd	1023	8	stopped	stop	VBN
cord-022594-fx044gcd	1023	9	several	several	JJ
cord-022594-fx044gcd	1023	10	months	month	NNS
cord-022594-fx044gcd	1023	11	before	before	IN
cord-022594-fx044gcd	1023	12	a	a	DT
cord-022594-fx044gcd	1023	13	planned	planned	JJ
cord-022594-fx044gcd	1023	14	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1023	15	.	.	.
cord-022594-fx044gcd	1024	1	PROGNOSIS	PROGNOSIS	NNP
cord-022594-fx044gcd	1024	2	AND	and	CC
cord-022594-fx044gcd	1024	3	FUTURE	future	JJ
cord-022594-fx044gcd	1024	4	PERSPECTIVES	perspective	NNS
cord-022594-fx044gcd	1024	5	.	.	.
cord-022594-fx044gcd	1025	1	Because	because	IN
cord-022594-fx044gcd	1025	2	most	most	JJS
cord-022594-fx044gcd	1025	3	information	information	NN
cord-022594-fx044gcd	1025	4	on	on	IN
cord-022594-fx044gcd	1025	5	the	the	DT
cord-022594-fx044gcd	1025	6	prognosis	prognosis	NN
cord-022594-fx044gcd	1025	7	of	of	IN
cord-022594-fx044gcd	1025	8	MS	MS	NNP
cord-022594-fx044gcd	1025	9	is	be	VBZ
cord-022594-fx044gcd	1025	10	reported	report	VBN
cord-022594-fx044gcd	1025	11	in	in	IN
cord-022594-fx044gcd	1025	12	terms	term	NNS
cord-022594-fx044gcd	1025	13	of	of	IN
cord-022594-fx044gcd	1025	14	the	the	DT
cord-022594-fx044gcd	1025	15	EDSS	EDSS	NNP
cord-022594-fx044gcd	1025	16	,	,	,
cord-022594-fx044gcd	1025	17	it	-PRON-	PRP
cord-022594-fx044gcd	1025	18	is	be	VBZ
cord-022594-fx044gcd	1025	19	important	important	JJ
cord-022594-fx044gcd	1025	20	to	to	TO
cord-022594-fx044gcd	1025	21	have	have	VB
cord-022594-fx044gcd	1025	22	some	some	DT
cord-022594-fx044gcd	1025	23	understanding	understanding	NN
cord-022594-fx044gcd	1025	24	of	of	IN
cord-022594-fx044gcd	1025	25	this	this	DT
cord-022594-fx044gcd	1025	26	scale	scale	NN
cord-022594-fx044gcd	1025	27	.	.	.
cord-022594-fx044gcd	1026	1	The	the	DT
cord-022594-fx044gcd	1026	2	EDSS	EDSS	NNP
cord-022594-fx044gcd	1026	3	is	be	VBZ
cord-022594-fx044gcd	1026	4	a	a	DT
cord-022594-fx044gcd	1026	5	10-point	10-point	JJ
cord-022594-fx044gcd	1026	6	scale	scale	NN
cord-022594-fx044gcd	1026	7	,	,	,
cord-022594-fx044gcd	1026	8	with	with	IN
cord-022594-fx044gcd	1026	9	each	each	DT
cord-022594-fx044gcd	1026	10	increase	increase	NN
cord-022594-fx044gcd	1026	11	representing	represent	VBG
cord-022594-fx044gcd	1026	12	worsening	worsen	VBG
cord-022594-fx044gcd	1026	13	symptoms	symptom	NNS
cord-022594-fx044gcd	1026	14	of	of	IN
cord-022594-fx044gcd	1026	15	function	function	NN
cord-022594-fx044gcd	1026	16	.	.	.
cord-022594-fx044gcd	1027	1	The	the	DT
cord-022594-fx044gcd	1027	2	score	score	NN
cord-022594-fx044gcd	1027	3	is	be	VBZ
cord-022594-fx044gcd	1027	4	derived	derive	VBN
cord-022594-fx044gcd	1027	5	from	from	IN
cord-022594-fx044gcd	1027	6	severity	severity	NN
cord-022594-fx044gcd	1027	7	scores	score	NNS
cord-022594-fx044gcd	1027	8	in	in	IN
cord-022594-fx044gcd	1027	9	each	each	DT
cord-022594-fx044gcd	1027	10	of	of	IN
cord-022594-fx044gcd	1027	11	six	six	CD
cord-022594-fx044gcd	1027	12	systems	system	NNS
cord-022594-fx044gcd	1027	13	as	as	RB
cord-022594-fx044gcd	1027	14	well	well	RB
cord-022594-fx044gcd	1027	15	as	as	IN
cord-022594-fx044gcd	1027	16	ambulation	ambulation	NN
cord-022594-fx044gcd	1027	17	and	and	CC
cord-022594-fx044gcd	1027	18	work	work	NN
cord-022594-fx044gcd	1027	19	ability	ability	NN
cord-022594-fx044gcd	1027	20	.	.	.
cord-022594-fx044gcd	1028	1	A	a	DT
cord-022594-fx044gcd	1028	2	score	score	NN
cord-022594-fx044gcd	1028	3	of	of	IN
cord-022594-fx044gcd	1028	4	0	0	CD
cord-022594-fx044gcd	1028	5	means	mean	VBZ
cord-022594-fx044gcd	1028	6	no	no	DT
cord-022594-fx044gcd	1028	7	signs	sign	NNS
cord-022594-fx044gcd	1028	8	or	or	CC
cord-022594-fx044gcd	1028	9	symptoms	symptom	NNS
cord-022594-fx044gcd	1028	10	;	;	:
cord-022594-fx044gcd	1028	11	1	1	CD
cord-022594-fx044gcd	1028	12	to	to	TO
cord-022594-fx044gcd	1028	13	3	3	CD
cord-022594-fx044gcd	1028	14	represent	represent	VB
cord-022594-fx044gcd	1028	15	mild	mild	JJ
cord-022594-fx044gcd	1028	16	disability	disability	NN
cord-022594-fx044gcd	1028	17	with	with	IN
cord-022594-fx044gcd	1028	18	no	no	DT
cord-022594-fx044gcd	1028	19	or	or	CC
cord-022594-fx044gcd	1028	20	minimal	minimal	JJ
cord-022594-fx044gcd	1028	21	impairment	impairment	NN
cord-022594-fx044gcd	1028	22	of	of	IN
cord-022594-fx044gcd	1028	23	ambulation	ambulation	NN
cord-022594-fx044gcd	1028	24	;	;	:
cord-022594-fx044gcd	1028	25	3.5	3.5	CD
cord-022594-fx044gcd	1028	26	to	to	TO
cord-022594-fx044gcd	1028	27	5.5	5.5	CD
cord-022594-fx044gcd	1028	28	refer	refer	NN
cord-022594-fx044gcd	1028	29	to	to	IN
cord-022594-fx044gcd	1028	30	moderate	moderate	JJ
cord-022594-fx044gcd	1028	31	disability	disability	NN
cord-022594-fx044gcd	1028	32	and	and	CC
cord-022594-fx044gcd	1028	33	impairment	impairment	NN
cord-022594-fx044gcd	1028	34	of	of	IN
cord-022594-fx044gcd	1028	35	gait	gait	NN
cord-022594-fx044gcd	1028	36	;	;	:
cord-022594-fx044gcd	1028	37	the	the	DT
cord-022594-fx044gcd	1028	38	need	need	NN
cord-022594-fx044gcd	1028	39	for	for	IN
cord-022594-fx044gcd	1028	40	a	a	DT
cord-022594-fx044gcd	1028	41	cane	cane	NN
cord-022594-fx044gcd	1028	42	to	to	TO
cord-022594-fx044gcd	1028	43	walk	walk	VB
cord-022594-fx044gcd	1028	44	one	one	CD
cord-022594-fx044gcd	1028	45	-	-	HYPH
cord-022594-fx044gcd	1028	46	half	half	NN
cord-022594-fx044gcd	1028	47	block	block	NN
cord-022594-fx044gcd	1028	48	(	(	-LRB-
cord-022594-fx044gcd	1028	49	100	100	CD
cord-022594-fx044gcd	1028	50	m	m	NN
cord-022594-fx044gcd	1028	51	)	)	-RRB-
cord-022594-fx044gcd	1028	52	receives	receive	VBZ
cord-022594-fx044gcd	1028	53	a	a	DT
cord-022594-fx044gcd	1028	54	score	score	NN
cord-022594-fx044gcd	1028	55	of	of	IN
cord-022594-fx044gcd	1028	56	6	6	CD
cord-022594-fx044gcd	1028	57	;	;	:
cord-022594-fx044gcd	1028	58	an	an	DT
cord-022594-fx044gcd	1028	59	EDSS	EDSS	NNP
cord-022594-fx044gcd	1028	60	of	of	IN
cord-022594-fx044gcd	1028	61	8	8	CD
cord-022594-fx044gcd	1028	62	refers	refer	VBZ
cord-022594-fx044gcd	1028	63	to	to	IN
cord-022594-fx044gcd	1028	64	the	the	DT
cord-022594-fx044gcd	1028	65	need	need	NN
cord-022594-fx044gcd	1028	66	for	for	IN
cord-022594-fx044gcd	1028	67	a	a	DT
cord-022594-fx044gcd	1028	68	wheelchair	wheelchair	NN
cord-022594-fx044gcd	1028	69	and	and	CC
cord-022594-fx044gcd	1028	70	effective	effective	JJ
cord-022594-fx044gcd	1028	71	upper	upper	JJ
cord-022594-fx044gcd	1028	72	extremity	extremity	NN
cord-022594-fx044gcd	1028	73	function	function	NN
cord-022594-fx044gcd	1028	74	;	;	:
cord-022594-fx044gcd	1028	75	an	an	DT
cord-022594-fx044gcd	1028	76	EDSS	EDSS	NNP
cord-022594-fx044gcd	1028	77	of	of	IN
cord-022594-fx044gcd	1028	78	10	10	CD
cord-022594-fx044gcd	1028	79	refers	refer	VBZ
cord-022594-fx044gcd	1028	80	to	to	IN
cord-022594-fx044gcd	1028	81	death	death	NN
cord-022594-fx044gcd	1028	82	related	relate	VBN
cord-022594-fx044gcd	1028	83	to	to	IN
cord-022594-fx044gcd	1028	84	MS	MS	NNP
cord-022594-fx044gcd	1028	85	.	.	.
cord-022594-fx044gcd	1029	1	MS	MS	NNP
cord-022594-fx044gcd	1029	2	has	have	VBZ
cord-022594-fx044gcd	1029	3	a	a	DT
cord-022594-fx044gcd	1029	4	highly	highly	RB
cord-022594-fx044gcd	1029	5	variable	variable	JJ
cord-022594-fx044gcd	1029	6	outcome	outcome	NN
cord-022594-fx044gcd	1029	7	,	,	,
cord-022594-fx044gcd	1029	8	ranging	range	VBG
cord-022594-fx044gcd	1029	9	from	from	IN
cord-022594-fx044gcd	1029	10	asymptomatic	asymptomatic	JJ
cord-022594-fx044gcd	1029	11	to	to	TO
cord-022594-fx044gcd	1029	12	fulminant	fulminant	VB
cord-022594-fx044gcd	1029	13	with	with	IN
cord-022594-fx044gcd	1029	14	death	death	NN
cord-022594-fx044gcd	1029	15	ensuing	ensue	VBG
cord-022594-fx044gcd	1029	16	in	in	IN
cord-022594-fx044gcd	1029	17	a	a	DT
cord-022594-fx044gcd	1029	18	matter	matter	NN
cord-022594-fx044gcd	1029	19	of	of	IN
cord-022594-fx044gcd	1029	20	months	month	NNS
cord-022594-fx044gcd	1029	21	.	.	.
cord-022594-fx044gcd	1030	1	Autopsy	autopsy	JJ
cord-022594-fx044gcd	1030	2	series	series	NN
cord-022594-fx044gcd	1030	3	have	have	VBP
cord-022594-fx044gcd	1030	4	estimated	estimate	VBN
cord-022594-fx044gcd	1030	5	that	that	IN
cord-022594-fx044gcd	1030	6	unsuspected	unsuspected	JJ
cord-022594-fx044gcd	1030	7	MS	MS	NNP
cord-022594-fx044gcd	1030	8	may	may	MD
cord-022594-fx044gcd	1030	9	occur	occur	VB
cord-022594-fx044gcd	1030	10	in	in	IN
cord-022594-fx044gcd	1030	11	as	as	RB
cord-022594-fx044gcd	1030	12	many	many	JJ
cord-022594-fx044gcd	1030	13	as	as	IN
cord-022594-fx044gcd	1030	14	0.2	0.2	CD
cord-022594-fx044gcd	1030	15	%	%	NN
cord-022594-fx044gcd	1030	16	of	of	IN
cord-022594-fx044gcd	1030	17	the	the	DT
cord-022594-fx044gcd	1030	18	population	population	NN
cord-022594-fx044gcd	1030	19	.	.	.
cord-022594-fx044gcd	1031	1	Even	even	RB
cord-022594-fx044gcd	1031	2	when	when	WRB
cord-022594-fx044gcd	1031	3	symptomatic	symptomatic	JJ
cord-022594-fx044gcd	1031	4	,	,	,
cord-022594-fx044gcd	1031	5	MS	MS	NNP
cord-022594-fx044gcd	1031	6	may	may	MD
cord-022594-fx044gcd	1031	7	cause	cause	VB
cord-022594-fx044gcd	1031	8	only	only	JJ
cord-022594-fx044gcd	1031	9	nuisance	nuisance	NN
cord-022594-fx044gcd	1031	10	symptoms	symptom	NNS
cord-022594-fx044gcd	1031	11	.	.	.
cord-022594-fx044gcd	1032	1	Benign	benign	JJ
cord-022594-fx044gcd	1032	2	MS	MS	NNP
cord-022594-fx044gcd	1032	3	,	,	,
cord-022594-fx044gcd	1032	4	when	when	WRB
cord-022594-fx044gcd	1032	5	defined	define	VBN
cord-022594-fx044gcd	1032	6	as	as	IN
cord-022594-fx044gcd	1032	7	unrestricted	unrestricted	JJ
cord-022594-fx044gcd	1032	8	ambulation	ambulation	NN
cord-022594-fx044gcd	1032	9	or	or	CC
cord-022594-fx044gcd	1032	10	EDSS	EDSS	NNP
cord-022594-fx044gcd	1032	11	of	of	IN
cord-022594-fx044gcd	1032	12	3	3	CD
cord-022594-fx044gcd	1032	13	or	or	CC
cord-022594-fx044gcd	1032	14	less	less	JJR
cord-022594-fx044gcd	1032	15	10	10	CD
cord-022594-fx044gcd	1032	16	years	year	NNS
cord-022594-fx044gcd	1032	17	after	after	IN
cord-022594-fx044gcd	1032	18	onset	onset	NN
cord-022594-fx044gcd	1032	19	,	,	,
cord-022594-fx044gcd	1032	20	accounts	account	VBZ
cord-022594-fx044gcd	1032	21	for	for	IN
cord-022594-fx044gcd	1032	22	about	about	RB
cord-022594-fx044gcd	1032	23	one	one	CD
cord-022594-fx044gcd	1032	24	third	third	NN
cord-022594-fx044gcd	1032	25	of	of	IN
cord-022594-fx044gcd	1032	26	cases	case	NNS
cord-022594-fx044gcd	1032	27	.	.	.
cord-022594-fx044gcd	1033	1	However	however	RB
cord-022594-fx044gcd	1033	2	,	,	,
cord-022594-fx044gcd	1033	3	many	many	JJ
cord-022594-fx044gcd	1033	4	of	of	IN
cord-022594-fx044gcd	1033	5	these	these	DT
cord-022594-fx044gcd	1033	6	patients	patient	NNS
cord-022594-fx044gcd	1033	7	acquire	acquire	VBP
cord-022594-fx044gcd	1033	8	more	more	JJR
cord-022594-fx044gcd	1033	9	disability	disability	NN
cord-022594-fx044gcd	1033	10	later	later	RB
cord-022594-fx044gcd	1033	11	.	.	.
cord-022594-fx044gcd	1034	1	When	when	WRB
cord-022594-fx044gcd	1034	2	considering	consider	VBG
cord-022594-fx044gcd	1034	3	all	all	DT
cord-022594-fx044gcd	1034	4	patients	patient	NNS
cord-022594-fx044gcd	1034	5	with	with	IN
cord-022594-fx044gcd	1034	6	MS	MS	NNP
cord-022594-fx044gcd	1034	7	,	,	,
cord-022594-fx044gcd	1034	8	Weinshenker	Weinshenker	NNP
cord-022594-fx044gcd	1034	9	found	find	VBD
cord-022594-fx044gcd	1034	10	that	that	IN
cord-022594-fx044gcd	1034	11	15	15	CD
cord-022594-fx044gcd	1034	12	years	year	NNS
cord-022594-fx044gcd	1034	13	after	after	IN
cord-022594-fx044gcd	1034	14	onset	onset	NN
cord-022594-fx044gcd	1034	15	,	,	,
cord-022594-fx044gcd	1034	16	80	80	CD
cord-022594-fx044gcd	1034	17	%	%	NN
cord-022594-fx044gcd	1034	18	had	have	VBD
cord-022594-fx044gcd	1034	19	EDSS	eds	VBN
cord-022594-fx044gcd	1034	20	worse	bad	JJR
cord-022594-fx044gcd	1034	21	than	than	IN
cord-022594-fx044gcd	1034	22	3	3	CD
cord-022594-fx044gcd	1034	23	,	,	,
cord-022594-fx044gcd	1034	24	50	50	CD
cord-022594-fx044gcd	1034	25	%	%	NN
cord-022594-fx044gcd	1034	26	had	have	VBD
cord-022594-fx044gcd	1034	27	reached	reach	VBN
cord-022594-fx044gcd	1034	28	EDSS	EDSS	NNP
cord-022594-fx044gcd	1034	29	of	of	IN
cord-022594-fx044gcd	1034	30	6	6	CD
cord-022594-fx044gcd	1034	31	or	or	CC
cord-022594-fx044gcd	1034	32	more	more	JJR
cord-022594-fx044gcd	1034	33	,	,	,
cord-022594-fx044gcd	1034	34	10	10	CD
cord-022594-fx044gcd	1034	35	%	%	NN
cord-022594-fx044gcd	1034	36	were	be	VBD
cord-022594-fx044gcd	1034	37	at	at	IN
cord-022594-fx044gcd	1034	38	EDSS	EDSS	NNP
cord-022594-fx044gcd	1034	39	8	8	CD
cord-022594-fx044gcd	1034	40	,	,	,
cord-022594-fx044gcd	1034	41	and	and	CC
cord-022594-fx044gcd	1034	42	2	2	CD
cord-022594-fx044gcd	1034	43	%	%	NN
cord-022594-fx044gcd	1034	44	had	have	VBD
cord-022594-fx044gcd	1034	45	died	die	VBN
cord-022594-fx044gcd	1034	46	.	.	.
cord-022594-fx044gcd	1035	1	The	the	DT
cord-022594-fx044gcd	1035	2	percentage	percentage	NN
cord-022594-fx044gcd	1035	3	of	of	IN
cord-022594-fx044gcd	1035	4	patients	patient	NNS
cord-022594-fx044gcd	1035	5	with	with	IN
cord-022594-fx044gcd	1035	6	initially	initially	RB
cord-022594-fx044gcd	1035	7	RRMS	RRMS	NNP
cord-022594-fx044gcd	1035	8	who	who	WP
cord-022594-fx044gcd	1035	9	develop	develop	VBP
cord-022594-fx044gcd	1035	10	SPMS	SPMS	NNP
cord-022594-fx044gcd	1035	11	increases	increase	NNS
cord-022594-fx044gcd	1035	12	steadily	steadily	RB
cord-022594-fx044gcd	1035	13	with	with	IN
cord-022594-fx044gcd	1035	14	disease	disease	NN
cord-022594-fx044gcd	1035	15	duration	duration	NN
cord-022594-fx044gcd	1035	16	.	.	.
cord-022594-fx044gcd	1036	1	113	113	CD
cord-022594-fx044gcd	1037	1	At	at	IN
cord-022594-fx044gcd	1037	2	10	10	CD
cord-022594-fx044gcd	1037	3	years	year	NNS
cord-022594-fx044gcd	1037	4	,	,	,
cord-022594-fx044gcd	1037	5	40	40	CD
cord-022594-fx044gcd	1037	6	%	%	NN
cord-022594-fx044gcd	1037	7	to	to	IN
cord-022594-fx044gcd	1037	8	50	50	CD
cord-022594-fx044gcd	1037	9	%	%	NN
cord-022594-fx044gcd	1037	10	have	have	VBP
cord-022594-fx044gcd	1037	11	continual	continual	JJ
cord-022594-fx044gcd	1037	12	deterioration	deterioration	NN
cord-022594-fx044gcd	1037	13	;	;	:
cord-022594-fx044gcd	1037	14	after	after	IN
cord-022594-fx044gcd	1037	15	25	25	CD
cord-022594-fx044gcd	1037	16	years	year	NNS
cord-022594-fx044gcd	1037	17	,	,	,
cord-022594-fx044gcd	1037	18	approximately	approximately	RB
cord-022594-fx044gcd	1037	19	80	80	CD
cord-022594-fx044gcd	1037	20	%	%	NN
cord-022594-fx044gcd	1037	21	have	have	VBP
cord-022594-fx044gcd	1037	22	slow	slow	JJ
cord-022594-fx044gcd	1037	23	progression	progression	NN
cord-022594-fx044gcd	1037	24	.	.	.
cord-022594-fx044gcd	1038	1	In	in	IN
cord-022594-fx044gcd	1038	2	the	the	DT
cord-022594-fx044gcd	1038	3	most	most	RBS
cord-022594-fx044gcd	1038	4	recent	recent	JJ
cord-022594-fx044gcd	1038	5	study	study	NN
cord-022594-fx044gcd	1038	6	published	publish	VBN
cord-022594-fx044gcd	1038	7	about	about	IN
cord-022594-fx044gcd	1038	8	the	the	DT
cord-022594-fx044gcd	1038	9	Olmsted	Olmsted	NNP
cord-022594-fx044gcd	1038	10	County	County	NNP
cord-022594-fx044gcd	1038	11	MS	MS	NNP
cord-022594-fx044gcd	1038	12	prevalence	prevalence	NN
cord-022594-fx044gcd	1038	13	cohort	cohort	NN
cord-022594-fx044gcd	1038	14	consisting	consist	VBG
cord-022594-fx044gcd	1038	15	of	of	IN
cord-022594-fx044gcd	1038	16	161	161	CD
cord-022594-fx044gcd	1038	17	patients	patient	NNS
cord-022594-fx044gcd	1038	18	,	,	,
cord-022594-fx044gcd	1038	19	the	the	DT
cord-022594-fx044gcd	1038	20	mean	mean	JJ
cord-022594-fx044gcd	1038	21	change	change	NN
cord-022594-fx044gcd	1038	22	in	in	IN
cord-022594-fx044gcd	1038	23	EDSS	EDSS	NNP
cord-022594-fx044gcd	1038	24	over	over	IN
cord-022594-fx044gcd	1038	25	10	10	CD
cord-022594-fx044gcd	1038	26	years	year	NNS
cord-022594-fx044gcd	1038	27	was	be	VBD
cord-022594-fx044gcd	1038	28	1	1	CD
cord-022594-fx044gcd	1038	29	point	point	NN
cord-022594-fx044gcd	1038	30	,	,	,
cord-022594-fx044gcd	1038	31	and	and	CC
cord-022594-fx044gcd	1038	32	only	only	RB
cord-022594-fx044gcd	1038	33	20	20	CD
cord-022594-fx044gcd	1038	34	%	%	NN
cord-022594-fx044gcd	1038	35	of	of	IN
cord-022594-fx044gcd	1038	36	patients	patient	NNS
cord-022594-fx044gcd	1038	37	had	have	VBD
cord-022594-fx044gcd	1038	38	a	a	DT
cord-022594-fx044gcd	1038	39	change	change	NN
cord-022594-fx044gcd	1038	40	larger	large	JJR
cord-022594-fx044gcd	1038	41	than	than	IN
cord-022594-fx044gcd	1038	42	2.0	2.0	CD
cord-022594-fx044gcd	1038	43	points	point	NNS
cord-022594-fx044gcd	1038	44	.	.	.
cord-022594-fx044gcd	1039	1	114	114	CD
cord-022594-fx044gcd	1039	2	Eighty	eighty	CD
cord-022594-fx044gcd	1039	3	-	-	HYPH
cord-022594-fx044gcd	1039	4	three	three	CD
cord-022594-fx044gcd	1039	5	percent	percent	NN
cord-022594-fx044gcd	1039	6	of	of	IN
cord-022594-fx044gcd	1039	7	the	the	DT
cord-022594-fx044gcd	1039	8	patients	patient	NNS
cord-022594-fx044gcd	1039	9	with	with	IN
cord-022594-fx044gcd	1039	10	mild	mild	JJ
cord-022594-fx044gcd	1039	11	symptoms	symptom	NNS
cord-022594-fx044gcd	1039	12	(	(	-LRB-
cord-022594-fx044gcd	1039	13	EDSS	EDSS	NNP
cord-022594-fx044gcd	1039	14	<	<	XX
cord-022594-fx044gcd	1039	15	3.0	3.0	CD
cord-022594-fx044gcd	1039	16	)	)	-RRB-
cord-022594-fx044gcd	1039	17	were	be	VBD
cord-022594-fx044gcd	1039	18	still	still	RB
cord-022594-fx044gcd	1039	19	ambulatory	ambulatory	JJ
cord-022594-fx044gcd	1039	20	without	without	IN
cord-022594-fx044gcd	1039	21	cane	cane	NN
cord-022594-fx044gcd	1039	22	10	10	CD
cord-022594-fx044gcd	1039	23	years	year	NNS
cord-022594-fx044gcd	1039	24	later	later	RB
cord-022594-fx044gcd	1039	25	.	.	.
cord-022594-fx044gcd	1040	1	Among	among	IN
cord-022594-fx044gcd	1040	2	the	the	DT
cord-022594-fx044gcd	1040	3	patients	patient	NNS
cord-022594-fx044gcd	1040	4	with	with	IN
cord-022594-fx044gcd	1040	5	an	an	DT
cord-022594-fx044gcd	1040	6	EDSS	EDSS	NNP
cord-022594-fx044gcd	1040	7	of	of	IN
cord-022594-fx044gcd	1040	8	3	3	CD
cord-022594-fx044gcd	1040	9	to	to	IN
cord-022594-fx044gcd	1040	10	5	5	CD
cord-022594-fx044gcd	1040	11	,	,	,
cord-022594-fx044gcd	1040	12	51	51	CD
cord-022594-fx044gcd	1040	13	%	%	NN
cord-022594-fx044gcd	1040	14	were	be	VBD
cord-022594-fx044gcd	1040	15	using	use	VBG
cord-022594-fx044gcd	1040	16	a	a	DT
cord-022594-fx044gcd	1040	17	cane	cane	NN
cord-022594-fx044gcd	1040	18	;	;	:
cord-022594-fx044gcd	1040	19	in	in	IN
cord-022594-fx044gcd	1040	20	the	the	DT
cord-022594-fx044gcd	1040	21	6	6	CD
cord-022594-fx044gcd	1040	22	to	to	TO
cord-022594-fx044gcd	1040	23	7	7	CD
cord-022594-fx044gcd	1040	24	EDDS	EDDS	NNP
cord-022594-fx044gcd	1040	25	range	range	NN
cord-022594-fx044gcd	1040	26	,	,	,
cord-022594-fx044gcd	1040	27	51	51	CD
cord-022594-fx044gcd	1040	28	%	%	NN
cord-022594-fx044gcd	1040	29	were	be	VBD
cord-022594-fx044gcd	1040	30	wheelchair	wheelchair	NN
cord-022594-fx044gcd	1040	31	bound	bound	JJ
cord-022594-fx044gcd	1040	32	.	.	.
cord-022594-fx044gcd	1041	1	Strong	strong	JJ
cord-022594-fx044gcd	1041	2	predictors	predictor	NNS
cord-022594-fx044gcd	1041	3	for	for	IN
cord-022594-fx044gcd	1041	4	the	the	DT
cord-022594-fx044gcd	1041	5	outcome	outcome	NN
cord-022594-fx044gcd	1041	6	were	be	VBD
cord-022594-fx044gcd	1041	7	not	not	RB
cord-022594-fx044gcd	1041	8	identified	identify	VBN
cord-022594-fx044gcd	1041	9	in	in	IN
cord-022594-fx044gcd	1041	10	this	this	DT
cord-022594-fx044gcd	1041	11	study	study	NN
cord-022594-fx044gcd	1041	12	.	.	.
cord-022594-fx044gcd	1042	1	Population	population	NN
cord-022594-fx044gcd	1042	2	-	-	HYPH
cord-022594-fx044gcd	1042	3	based	base	VBN
cord-022594-fx044gcd	1042	4	studies	study	NNS
cord-022594-fx044gcd	1042	5	with	with	IN
cord-022594-fx044gcd	1042	6	complete	complete	JJ
cord-022594-fx044gcd	1042	7	ascertainment	ascertainment	NN
cord-022594-fx044gcd	1042	8	can	can	MD
cord-022594-fx044gcd	1042	9	effectively	effectively	RB
cord-022594-fx044gcd	1042	10	remove	remove	VB
cord-022594-fx044gcd	1042	11	the	the	DT
cord-022594-fx044gcd	1042	12	bias	bias	NN
cord-022594-fx044gcd	1042	13	of	of	IN
cord-022594-fx044gcd	1042	14	a	a	DT
cord-022594-fx044gcd	1042	15	referral	referral	JJ
cord-022594-fx044gcd	1042	16	practice	practice	NN
cord-022594-fx044gcd	1042	17	,	,	,
cord-022594-fx044gcd	1042	18	which	which	WDT
cord-022594-fx044gcd	1042	19	is	be	VBZ
cord-022594-fx044gcd	1042	20	inherently	inherently	RB
cord-022594-fx044gcd	1042	21	biased	biased	JJ
cord-022594-fx044gcd	1042	22	towards	towards	IN
cord-022594-fx044gcd	1042	23	the	the	DT
cord-022594-fx044gcd	1042	24	more	more	RBR
cord-022594-fx044gcd	1042	25	active	active	JJ
cord-022594-fx044gcd	1042	26	and	and	CC
cord-022594-fx044gcd	1042	27	more	more	RBR
cord-022594-fx044gcd	1042	28	serious	serious	JJ
cord-022594-fx044gcd	1042	29	cases	case	NNS
cord-022594-fx044gcd	1042	30	.	.	.
cord-022594-fx044gcd	1043	1	These	these	DT
cord-022594-fx044gcd	1043	2	studies	study	NNS
cord-022594-fx044gcd	1043	3	also	also	RB
cord-022594-fx044gcd	1043	4	provide	provide	VBP
cord-022594-fx044gcd	1043	5	some	some	DT
cord-022594-fx044gcd	1043	6	much	much	JJ
cord-022594-fx044gcd	1043	7	needed	need	VBN
cord-022594-fx044gcd	1043	8	balance	balance	NN
cord-022594-fx044gcd	1043	9	to	to	IN
cord-022594-fx044gcd	1043	10	the	the	DT
cord-022594-fx044gcd	1043	11	"	"	``
cord-022594-fx044gcd	1043	12	heavily	heavily	RB
cord-022594-fx044gcd	1043	13	skewed	skewed	JJ
cord-022594-fx044gcd	1043	14	for	for	IN
cord-022594-fx044gcd	1043	15	recent	recent	JJ
cord-022594-fx044gcd	1043	16	disease	disease	NN
cord-022594-fx044gcd	1043	17	activity	activity	NN
cord-022594-fx044gcd	1043	18	"	"	''
cord-022594-fx044gcd	1043	19	clinical	clinical	JJ
cord-022594-fx044gcd	1043	20	trial	trial	NN
cord-022594-fx044gcd	1043	21	experience	experience	NN
cord-022594-fx044gcd	1043	22	.	.	.
cord-022594-fx044gcd	1044	1	From	from	IN
cord-022594-fx044gcd	1044	2	the	the	DT
cord-022594-fx044gcd	1044	3	most	most	RBS
cord-022594-fx044gcd	1044	4	recent	recent	JJ
cord-022594-fx044gcd	1044	5	extensions	extension	NNS
cord-022594-fx044gcd	1044	6	to	to	IN
cord-022594-fx044gcd	1044	7	the	the	DT
cord-022594-fx044gcd	1044	8	Olmsted	Olmsted	NNP
cord-022594-fx044gcd	1044	9	County	County	NNP
cord-022594-fx044gcd	1044	10	MS	MS	NNP
cord-022594-fx044gcd	1044	11	cohort	cohort	NN
cord-022594-fx044gcd	1044	12	studies	study	NNS
cord-022594-fx044gcd	1044	13	conducted	conduct	VBN
cord-022594-fx044gcd	1044	14	by	by	IN
cord-022594-fx044gcd	1044	15	the	the	DT
cord-022594-fx044gcd	1044	16	Mayo	Mayo	NNP
cord-022594-fx044gcd	1044	17	group	group	NN
cord-022594-fx044gcd	1044	18	,	,	,
cord-022594-fx044gcd	1044	19	several	several	JJ
cord-022594-fx044gcd	1044	20	conclusions	conclusion	NNS
cord-022594-fx044gcd	1044	21	can	can	MD
cord-022594-fx044gcd	1044	22	be	be	VB
cord-022594-fx044gcd	1044	23	drawn	draw	VBN
cord-022594-fx044gcd	1044	24	.	.	.
cord-022594-fx044gcd	1045	1	The	the	DT
cord-022594-fx044gcd	1045	2	number	number	NN
cord-022594-fx044gcd	1045	3	of	of	IN
cord-022594-fx044gcd	1045	4	relapses	relapse	NNS
cord-022594-fx044gcd	1045	5	in	in	IN
cord-022594-fx044gcd	1045	6	the	the	DT
cord-022594-fx044gcd	1045	7	first	first	JJ
cord-022594-fx044gcd	1045	8	year	year	NN
cord-022594-fx044gcd	1045	9	of	of	IN
cord-022594-fx044gcd	1045	10	the	the	DT
cord-022594-fx044gcd	1045	11	disease	disease	NN
cord-022594-fx044gcd	1045	12	do	do	VBP
cord-022594-fx044gcd	1045	13	not	not	RB
cord-022594-fx044gcd	1045	14	predict	predict	VB
cord-022594-fx044gcd	1045	15	long	long	JJ
cord-022594-fx044gcd	1045	16	term	term	NN
cord-022594-fx044gcd	1045	17	outcome	outcome	NN
cord-022594-fx044gcd	1045	18	.	.	.
cord-022594-fx044gcd	1046	1	The	the	DT
cord-022594-fx044gcd	1046	2	time	time	NN
cord-022594-fx044gcd	1046	3	to	to	IN
cord-022594-fx044gcd	1046	4	disability	disability	NN
cord-022594-fx044gcd	1046	5	is	be	VBZ
cord-022594-fx044gcd	1046	6	not	not	RB
cord-022594-fx044gcd	1046	7	influenced	influence	VBN
cord-022594-fx044gcd	1046	8	by	by	IN
cord-022594-fx044gcd	1046	9	ongoing	ongoing	JJ
cord-022594-fx044gcd	1046	10	relapses	relapse	NNS
cord-022594-fx044gcd	1046	11	once	once	IN
cord-022594-fx044gcd	1046	12	patients	patient	NNS
cord-022594-fx044gcd	1046	13	achieve	achieve	VBP
cord-022594-fx044gcd	1046	14	an	an	DT
cord-022594-fx044gcd	1046	15	apparently	apparently	RB
cord-022594-fx044gcd	1046	16	permanent	permanent	JJ
cord-022594-fx044gcd	1046	17	degree	degree	NN
cord-022594-fx044gcd	1046	18	of	of	IN
cord-022594-fx044gcd	1046	19	moderate	moderate	JJ
cord-022594-fx044gcd	1046	20	disability	disability	NN
cord-022594-fx044gcd	1046	21	(	(	-LRB-
cord-022594-fx044gcd	1046	22	EDSS	EDSS	NNP
cord-022594-fx044gcd	1046	23	3.5	3.5	CD
cord-022594-fx044gcd	1046	24	)	)	-RRB-
cord-022594-fx044gcd	1046	25	.	.	.
cord-022594-fx044gcd	1047	1	Overall	overall	RB
cord-022594-fx044gcd	1047	2	,	,	,
cord-022594-fx044gcd	1047	3	80	80	CD
cord-022594-fx044gcd	1047	4	%	%	NN
cord-022594-fx044gcd	1047	5	patients	patient	NNS
cord-022594-fx044gcd	1047	6	who	who	WP
cord-022594-fx044gcd	1047	7	are	be	VBP
cord-022594-fx044gcd	1047	8	still	still	RB
cord-022594-fx044gcd	1047	9	classified	classify	VBN
cord-022594-fx044gcd	1047	10	as	as	IN
cord-022594-fx044gcd	1047	11	RRMS	RRMS	NNP
cord-022594-fx044gcd	1047	12	into	into	IN
cord-022594-fx044gcd	1047	13	their	-PRON-	PRP$
cord-022594-fx044gcd	1047	14	second	second	JJ
cord-022594-fx044gcd	1047	15	decade	decade	NN
cord-022594-fx044gcd	1047	16	of	of	IN
cord-022594-fx044gcd	1047	17	disease	disease	NN
cord-022594-fx044gcd	1047	18	continue	continue	VBP
cord-022594-fx044gcd	1047	19	to	to	TO
cord-022594-fx044gcd	1047	20	do	do	VB
cord-022594-fx044gcd	1047	21	well	well	RB
cord-022594-fx044gcd	1047	22	for	for	IN
cord-022594-fx044gcd	1047	23	15	15	CD
cord-022594-fx044gcd	1047	24	to	to	TO
cord-022594-fx044gcd	1047	25	20	20	CD
cord-022594-fx044gcd	1047	26	years	year	NNS
cord-022594-fx044gcd	1047	27	with	with	IN
cord-022594-fx044gcd	1047	28	limited	limited	JJ
cord-022594-fx044gcd	1047	29	permanent	permanent	JJ
cord-022594-fx044gcd	1047	30	disability	disability	NN
cord-022594-fx044gcd	1047	31	.	.	.
cord-022594-fx044gcd	1048	1	Patients	patient	NNS
cord-022594-fx044gcd	1048	2	doing	do	VBG
cord-022594-fx044gcd	1048	3	extremely	extremely	RB
cord-022594-fx044gcd	1048	4	well	well	RB
cord-022594-fx044gcd	1048	5	(	(	-LRB-
cord-022594-fx044gcd	1048	6	EDSS	EDSS	NNP
cord-022594-fx044gcd	1048	7	2.0	2.0	CD
cord-022594-fx044gcd	1048	8	)	)	-RRB-
cord-022594-fx044gcd	1048	9	after	after	IN
cord-022594-fx044gcd	1048	10	10	10	CD
cord-022594-fx044gcd	1048	11	years	year	NNS
cord-022594-fx044gcd	1048	12	of	of	IN
cord-022594-fx044gcd	1048	13	MS	MS	NNP
cord-022594-fx044gcd	1048	14	generally	generally	RB
cord-022594-fx044gcd	1048	15	do	do	VBP
cord-022594-fx044gcd	1048	16	well	well	RB
cord-022594-fx044gcd	1048	17	in	in	IN
cord-022594-fx044gcd	1048	18	the	the	DT
cord-022594-fx044gcd	1048	19	next	next	JJ
cord-022594-fx044gcd	1048	20	decade	decade	NN
cord-022594-fx044gcd	1048	21	.	.	.
cord-022594-fx044gcd	1049	1	However	however	RB
cord-022594-fx044gcd	1049	2	,	,	,
cord-022594-fx044gcd	1049	3	very	very	RB
cord-022594-fx044gcd	1049	4	rarely	rarely	RB
cord-022594-fx044gcd	1049	5	patients	patient	NNS
cord-022594-fx044gcd	1049	6	doing	do	VBG
cord-022594-fx044gcd	1049	7	well	well	RB
cord-022594-fx044gcd	1049	8	even	even	RB
cord-022594-fx044gcd	1049	9	for	for	IN
cord-022594-fx044gcd	1049	10	2	2	CD
cord-022594-fx044gcd	1049	11	to	to	TO
cord-022594-fx044gcd	1049	12	3	3	CD
cord-022594-fx044gcd	1049	13	decades	decade	NNS
cord-022594-fx044gcd	1049	14	may	may	MD
cord-022594-fx044gcd	1049	15	develop	develop	VB
cord-022594-fx044gcd	1049	16	severe	severe	JJ
cord-022594-fx044gcd	1049	17	late	late	JJ
cord-022594-fx044gcd	1049	18	disability	disability	NN
cord-022594-fx044gcd	1049	19	.	.	.
cord-022594-fx044gcd	1050	1	We	-PRON-	PRP
cord-022594-fx044gcd	1050	2	advise	advise	VBP
cord-022594-fx044gcd	1050	3	that	that	IN
cord-022594-fx044gcd	1050	4	neurologists	neurologist	NNS
cord-022594-fx044gcd	1050	5	share	share	VBP
cord-022594-fx044gcd	1050	6	these	these	DT
cord-022594-fx044gcd	1050	7	findings	finding	NNS
cord-022594-fx044gcd	1050	8	with	with	IN
cord-022594-fx044gcd	1050	9	patients	patient	NNS
cord-022594-fx044gcd	1050	10	who	who	WP
cord-022594-fx044gcd	1050	11	are	be	VBP
cord-022594-fx044gcd	1050	12	in	in	IN
cord-022594-fx044gcd	1050	13	periods	period	NNS
cord-022594-fx044gcd	1050	14	of	of	IN
cord-022594-fx044gcd	1050	15	prolonged	prolong	VBN
cord-022594-fx044gcd	1050	16	remission	remission	NN
cord-022594-fx044gcd	1050	17	during	during	IN
cord-022594-fx044gcd	1050	18	the	the	DT
cord-022594-fx044gcd	1050	19	discussions	discussion	NNS
cord-022594-fx044gcd	1050	20	about	about	IN
cord-022594-fx044gcd	1050	21	the	the	DT
cord-022594-fx044gcd	1050	22	merits	merit	NNS
cord-022594-fx044gcd	1050	23	of	of	IN
cord-022594-fx044gcd	1050	24	beginning	begin	VBG
cord-022594-fx044gcd	1050	25	disease	disease	NN
cord-022594-fx044gcd	1050	26	-	-	HYPH
cord-022594-fx044gcd	1050	27	modifying	modify	VBG
cord-022594-fx044gcd	1050	28	agents	agent	NNS
cord-022594-fx044gcd	1050	29	.	.	.
cord-022594-fx044gcd	1051	1	Natural	natural	JJ
cord-022594-fx044gcd	1051	2	history	history	NN
cord-022594-fx044gcd	1051	3	studies	study	NNS
cord-022594-fx044gcd	1051	4	have	have	VBP
cord-022594-fx044gcd	1051	5	identified	identify	VBN
cord-022594-fx044gcd	1051	6	several	several	JJ
cord-022594-fx044gcd	1051	7	prognostic	prognostic	JJ
cord-022594-fx044gcd	1051	8	indicators	indicator	NNS
cord-022594-fx044gcd	1051	9	that	that	WDT
cord-022594-fx044gcd	1051	10	predict	predict	VBP
cord-022594-fx044gcd	1051	11	outcome	outcome	NN
cord-022594-fx044gcd	1051	12	to	to	IN
cord-022594-fx044gcd	1051	13	a	a	DT
cord-022594-fx044gcd	1051	14	limited	limited	JJ
cord-022594-fx044gcd	1051	15	extent	extent	NN
cord-022594-fx044gcd	1051	16	.	.	.
cord-022594-fx044gcd	1052	1	Factors	factor	NNS
cord-022594-fx044gcd	1052	2	associated	associate	VBN
cord-022594-fx044gcd	1052	3	with	with	IN
cord-022594-fx044gcd	1052	4	a	a	DT
cord-022594-fx044gcd	1052	5	better	well	JJR
cord-022594-fx044gcd	1052	6	prognosis	prognosis	NN
cord-022594-fx044gcd	1052	7	(	(	-LRB-
cord-022594-fx044gcd	1052	8	slower	slow	JJR
cord-022594-fx044gcd	1052	9	accumulation	accumulation	NN
cord-022594-fx044gcd	1052	10	of	of	IN
cord-022594-fx044gcd	1052	11	disability	disability	NN
cord-022594-fx044gcd	1052	12	,	,	,
cord-022594-fx044gcd	1052	13	longer	long	JJR
cord-022594-fx044gcd	1052	14	time	time	NN
cord-022594-fx044gcd	1052	15	before	before	IN
cord-022594-fx044gcd	1052	16	chronic	chronic	JJ
cord-022594-fx044gcd	1052	17	progression	progression	NN
cord-022594-fx044gcd	1052	18	)	)	-RRB-
cord-022594-fx044gcd	1052	19	include	include	VBP
cord-022594-fx044gcd	1052	20	young	young	JJ
cord-022594-fx044gcd	1052	21	age	age	NN
cord-022594-fx044gcd	1052	22	at	at	IN
cord-022594-fx044gcd	1052	23	onset	onset	NN
cord-022594-fx044gcd	1052	24	,	,	,
cord-022594-fx044gcd	1052	25	female	female	JJ
cord-022594-fx044gcd	1052	26	gender	gender	NN
cord-022594-fx044gcd	1052	27	,	,	,
cord-022594-fx044gcd	1052	28	RR	rr	NN
cord-022594-fx044gcd	1052	29	course	course	NN
cord-022594-fx044gcd	1052	30	(	(	-LRB-
cord-022594-fx044gcd	1052	31	as	as	IN
cord-022594-fx044gcd	1052	32	opposed	oppose	VBN
cord-022594-fx044gcd	1052	33	to	to	IN
cord-022594-fx044gcd	1052	34	PPMS	PPMS	NNP
cord-022594-fx044gcd	1052	35	)	)	-RRB-
cord-022594-fx044gcd	1052	36	,	,	,
cord-022594-fx044gcd	1052	37	initial	initial	JJ
cord-022594-fx044gcd	1052	38	symptoms	symptom	NNS
cord-022594-fx044gcd	1052	39	of	of	IN
cord-022594-fx044gcd	1052	40	sensory	sensory	JJ
cord-022594-fx044gcd	1052	41	impairment	impairment	NN
cord-022594-fx044gcd	1052	42	or	or	CC
cord-022594-fx044gcd	1052	43	ON	on	RB
cord-022594-fx044gcd	1052	44	,	,	,
cord-022594-fx044gcd	1052	45	first	first	JJ
cord-022594-fx044gcd	1052	46	manifestations	manifestation	NNS
cord-022594-fx044gcd	1052	47	affecting	affect	VBG
cord-022594-fx044gcd	1052	48	only	only	RB
cord-022594-fx044gcd	1052	49	one	one	CD
cord-022594-fx044gcd	1052	50	CNS	CNS	NNP
cord-022594-fx044gcd	1052	51	region	region	NN
cord-022594-fx044gcd	1052	52	,	,	,
cord-022594-fx044gcd	1052	53	high	high	JJ
cord-022594-fx044gcd	1052	54	degree	degree	NN
cord-022594-fx044gcd	1052	55	of	of	IN
cord-022594-fx044gcd	1052	56	recovery	recovery	NN
cord-022594-fx044gcd	1052	57	from	from	IN
cord-022594-fx044gcd	1052	58	initial	initial	JJ
cord-022594-fx044gcd	1052	59	bout	bout	NN
cord-022594-fx044gcd	1052	60	,	,	,
cord-022594-fx044gcd	1052	61	longer	long	JJR
cord-022594-fx044gcd	1052	62	interval	interval	NN
cord-022594-fx044gcd	1052	63	between	between	IN
cord-022594-fx044gcd	1052	64	first	first	JJ
cord-022594-fx044gcd	1052	65	and	and	CC
cord-022594-fx044gcd	1052	66	second	second	JJ
cord-022594-fx044gcd	1052	67	relapses	relapse	NNS
cord-022594-fx044gcd	1052	68	,	,	,
cord-022594-fx044gcd	1052	69	low	low	JJ
cord-022594-fx044gcd	1052	70	number	number	NN
cord-022594-fx044gcd	1052	71	of	of	IN
cord-022594-fx044gcd	1052	72	relapses	relapse	NNS
cord-022594-fx044gcd	1052	73	in	in	IN
cord-022594-fx044gcd	1052	74	the	the	DT
cord-022594-fx044gcd	1052	75	first	first	JJ
cord-022594-fx044gcd	1052	76	2	2	CD
cord-022594-fx044gcd	1052	77	years	year	NNS
cord-022594-fx044gcd	1052	78	,	,	,
cord-022594-fx044gcd	1052	79	and	and	CC
cord-022594-fx044gcd	1052	80	less	less	JJR
cord-022594-fx044gcd	1052	81	disability	disability	NN
cord-022594-fx044gcd	1052	82	at	at	IN
cord-022594-fx044gcd	1052	83	5	5	CD
cord-022594-fx044gcd	1052	84	years	year	NNS
cord-022594-fx044gcd	1052	85	after	after	IN
cord-022594-fx044gcd	1052	86	onset	onset	NN
cord-022594-fx044gcd	1052	87	(	(	-LRB-
cord-022594-fx044gcd	1052	88	both	both	DT
cord-022594-fx044gcd	1052	89	EDSS	eds	NNS
cord-022594-fx044gcd	1052	90	and	and	CC
cord-022594-fx044gcd	1052	91	number	number	NN
cord-022594-fx044gcd	1052	92	of	of	IN
cord-022594-fx044gcd	1052	93	systems	system	NNS
cord-022594-fx044gcd	1052	94	affected	affect	VBN
cord-022594-fx044gcd	1052	95	-	-	HYPH
cord-022594-fx044gcd	1052	96	sensory	sensory	JJ
cord-022594-fx044gcd	1052	97	,	,	,
cord-022594-fx044gcd	1052	98	motor	motor	NN
cord-022594-fx044gcd	1052	99	,	,	,
cord-022594-fx044gcd	1052	100	sphincter	sphincter	NN
cord-022594-fx044gcd	1052	101	,	,	,
cord-022594-fx044gcd	1052	102	brain	brain	NN
cord-022594-fx044gcd	1052	103	stem	stem	NN
cord-022594-fx044gcd	1052	104	,	,	,
cord-022594-fx044gcd	1052	105	vision	vision	NN
cord-022594-fx044gcd	1052	106	,	,	,
cord-022594-fx044gcd	1052	107	cerebral	cerebral	JJ
cord-022594-fx044gcd	1052	108	)	)	-RRB-
cord-022594-fx044gcd	1052	109	.	.	.
cord-022594-fx044gcd	1053	1	Despite	despite	IN
cord-022594-fx044gcd	1053	2	the	the	DT
cord-022594-fx044gcd	1053	3	indolent	indolent	JJ
cord-022594-fx044gcd	1053	4	nature	nature	NN
cord-022594-fx044gcd	1053	5	,	,	,
cord-022594-fx044gcd	1053	6	a	a	DT
cord-022594-fx044gcd	1053	7	PP	pp	NN
cord-022594-fx044gcd	1053	8	course	course	NN
cord-022594-fx044gcd	1053	9	is	be	VBZ
cord-022594-fx044gcd	1053	10	the	the	DT
cord-022594-fx044gcd	1053	11	worst	bad	JJS
cord-022594-fx044gcd	1053	12	prognostic	prognostic	JJ
cord-022594-fx044gcd	1053	13	factor	factor	NN
cord-022594-fx044gcd	1053	14	,	,	,
cord-022594-fx044gcd	1053	15	with	with	IN
cord-022594-fx044gcd	1053	16	the	the	DT
cord-022594-fx044gcd	1053	17	median	median	JJ
cord-022594-fx044gcd	1053	18	time	time	NN
cord-022594-fx044gcd	1053	19	to	to	TO
cord-022594-fx044gcd	1053	20	reach	reach	VB
cord-022594-fx044gcd	1053	21	EDSS	EDSS	NNP
cord-022594-fx044gcd	1053	22	6	6	CD
cord-022594-fx044gcd	1053	23	of	of	IN
cord-022594-fx044gcd	1053	24	only	only	RB
cord-022594-fx044gcd	1053	25	6	6	CD
cord-022594-fx044gcd	1053	26	years	year	NNS
cord-022594-fx044gcd	1053	27	,	,	,
cord-022594-fx044gcd	1053	28	compared	compare	VBN
cord-022594-fx044gcd	1053	29	with	with	IN
cord-022594-fx044gcd	1053	30	approximately	approximately	RB
cord-022594-fx044gcd	1053	31	20	20	CD
cord-022594-fx044gcd	1053	32	years	year	NNS
cord-022594-fx044gcd	1053	33	in	in	IN
cord-022594-fx044gcd	1053	34	RR	rr	NN
cord-022594-fx044gcd	1053	35	patients	patient	NNS
cord-022594-fx044gcd	1053	36	.	.	.
cord-022594-fx044gcd	1054	1	Men	man	NNS
cord-022594-fx044gcd	1054	2	and	and	CC
cord-022594-fx044gcd	1054	3	patients	patient	NNS
cord-022594-fx044gcd	1054	4	with	with	IN
cord-022594-fx044gcd	1054	5	an	an	DT
cord-022594-fx044gcd	1054	6	older	old	JJR
cord-022594-fx044gcd	1054	7	age	age	NN
cord-022594-fx044gcd	1054	8	at	at	IN
cord-022594-fx044gcd	1054	9	onset	onset	NN
cord-022594-fx044gcd	1054	10	are	be	VBP
cord-022594-fx044gcd	1054	11	more	more	RBR
cord-022594-fx044gcd	1054	12	likely	likely	JJ
cord-022594-fx044gcd	1054	13	to	to	TO
cord-022594-fx044gcd	1054	14	have	have	VB
cord-022594-fx044gcd	1054	15	PPMS	PPMS	NNP
cord-022594-fx044gcd	1054	16	.	.	.
cord-022594-fx044gcd	1055	1	The	the	DT
cord-022594-fx044gcd	1055	2	survival	survival	NN
cord-022594-fx044gcd	1055	3	of	of	IN
cord-022594-fx044gcd	1055	4	MS	MS	NNP
cord-022594-fx044gcd	1055	5	patients	patient	NNS
cord-022594-fx044gcd	1055	6	is	be	VBZ
cord-022594-fx044gcd	1055	7	only	only	RB
cord-022594-fx044gcd	1055	8	slightly	slightly	RB
cord-022594-fx044gcd	1055	9	below	below	IN
cord-022594-fx044gcd	1055	10	expected	expect	VBN
cord-022594-fx044gcd	1055	11	.	.	.
cord-022594-fx044gcd	1056	1	Seventy	seventy	CD
cord-022594-fx044gcd	1056	2	-	-	HYPH
cord-022594-fx044gcd	1056	3	six	six	CD
cord-022594-fx044gcd	1056	4	percent	percent	NN
cord-022594-fx044gcd	1056	5	of	of	IN
cord-022594-fx044gcd	1056	6	patients	patient	NNS
cord-022594-fx044gcd	1056	7	are	be	VBP
cord-022594-fx044gcd	1056	8	alive	alive	JJ
cord-022594-fx044gcd	1056	9	25	25	CD
cord-022594-fx044gcd	1056	10	years	year	NNS
cord-022594-fx044gcd	1056	11	after	after	IN
cord-022594-fx044gcd	1056	12	onset	onset	NN
cord-022594-fx044gcd	1056	13	,	,	,
cord-022594-fx044gcd	1056	14	which	which	WDT
cord-022594-fx044gcd	1056	15	is	be	VBZ
cord-022594-fx044gcd	1056	16	85	85	CD
cord-022594-fx044gcd	1056	17	%	%	NN
cord-022594-fx044gcd	1056	18	of	of	IN
cord-022594-fx044gcd	1056	19	that	that	DT
cord-022594-fx044gcd	1056	20	seen	see	VBN
cord-022594-fx044gcd	1056	21	in	in	IN
cord-022594-fx044gcd	1056	22	age	age	NN
cord-022594-fx044gcd	1056	23	-	-	HYPH
cord-022594-fx044gcd	1056	24	and	and	CC
cord-022594-fx044gcd	1056	25	sexmatched	sexmatched	JJ
cord-022594-fx044gcd	1056	26	control	control	NN
cord-022594-fx044gcd	1056	27	subjects	subject	NNS
cord-022594-fx044gcd	1056	28	.	.	.
cord-022594-fx044gcd	1057	1	35	35	CD
cord-022594-fx044gcd	1057	2	MS	MS	NNP
cord-022594-fx044gcd	1057	3	is	be	VBZ
cord-022594-fx044gcd	1057	4	rarely	rarely	RB
cord-022594-fx044gcd	1057	5	the	the	DT
cord-022594-fx044gcd	1057	6	direct	direct	JJ
cord-022594-fx044gcd	1057	7	cause	cause	NN
cord-022594-fx044gcd	1057	8	of	of	IN
cord-022594-fx044gcd	1057	9	death	death	NN
cord-022594-fx044gcd	1057	10	.	.	.
cord-022594-fx044gcd	1058	1	Complications	complication	NNS
cord-022594-fx044gcd	1058	2	of	of	IN
cord-022594-fx044gcd	1058	3	MS	MS	NNP
cord-022594-fx044gcd	1058	4	such	such	JJ
cord-022594-fx044gcd	1058	5	as	as	IN
cord-022594-fx044gcd	1058	6	pneumonia	pneumonia	NN
cord-022594-fx044gcd	1058	7	,	,	,
cord-022594-fx044gcd	1058	8	pulmonary	pulmonary	JJ
cord-022594-fx044gcd	1058	9	emboli	emboli	NN
cord-022594-fx044gcd	1058	10	,	,	,
cord-022594-fx044gcd	1058	11	aspiration	aspiration	NN
cord-022594-fx044gcd	1058	12	,	,	,
cord-022594-fx044gcd	1058	13	urosepsis	urosepsis	NN
cord-022594-fx044gcd	1058	14	,	,	,
cord-022594-fx044gcd	1058	15	and	and	CC
cord-022594-fx044gcd	1058	16	decubiti	decubiti	NNP
cord-022594-fx044gcd	1058	17	are	be	VBP
cord-022594-fx044gcd	1058	18	responsible	responsible	JJ
cord-022594-fx044gcd	1058	19	for	for	IN
cord-022594-fx044gcd	1058	20	50	50	CD
cord-022594-fx044gcd	1058	21	%	%	NN
cord-022594-fx044gcd	1058	22	of	of	IN
cord-022594-fx044gcd	1058	23	deaths	death	NNS
cord-022594-fx044gcd	1058	24	.	.	.
cord-022594-fx044gcd	1059	1	Most	Most	JJS
cord-022594-fx044gcd	1059	2	of	of	IN
cord-022594-fx044gcd	1059	3	the	the	DT
cord-022594-fx044gcd	1059	4	other	other	JJ
cord-022594-fx044gcd	1059	5	deaths	death	NNS
cord-022594-fx044gcd	1059	6	are	be	VBP
cord-022594-fx044gcd	1059	7	from	from	IN
cord-022594-fx044gcd	1059	8	heart	heart	NN
cord-022594-fx044gcd	1059	9	disease	disease	NN
cord-022594-fx044gcd	1059	10	,	,	,
cord-022594-fx044gcd	1059	11	cancer	cancer	NN
cord-022594-fx044gcd	1059	12	,	,	,
cord-022594-fx044gcd	1059	13	cerebrovascular	cerebrovascular	JJ
cord-022594-fx044gcd	1059	14	disease	disease	NN
cord-022594-fx044gcd	1059	15	,	,	,
cord-022594-fx044gcd	1059	16	and	and	CC
cord-022594-fx044gcd	1059	17	trauma	trauma	NN
cord-022594-fx044gcd	1059	18	.	.	.
cord-022594-fx044gcd	1060	1	Suicide	suicide	NN
cord-022594-fx044gcd	1060	2	is	be	VBZ
cord-022594-fx044gcd	1060	3	the	the	DT
cord-022594-fx044gcd	1060	4	only	only	JJ
cord-022594-fx044gcd	1060	5	cause	cause	NN
cord-022594-fx044gcd	1060	6	of	of	IN
cord-022594-fx044gcd	1060	7	death	death	NN
cord-022594-fx044gcd	1060	8	that	that	WDT
cord-022594-fx044gcd	1060	9	is	be	VBZ
cord-022594-fx044gcd	1060	10	overrepresented	overrepresente	VBN
cord-022594-fx044gcd	1060	11	among	among	IN
cord-022594-fx044gcd	1060	12	these	these	DT
cord-022594-fx044gcd	1060	13	cases	case	NNS
cord-022594-fx044gcd	1060	14	.	.	.
cord-022594-fx044gcd	1061	1	The	the	DT
cord-022594-fx044gcd	1061	2	suicide	suicide	NN
cord-022594-fx044gcd	1061	3	rate	rate	NN
cord-022594-fx044gcd	1061	4	among	among	IN
cord-022594-fx044gcd	1061	5	MS	MS	NNP
cord-022594-fx044gcd	1061	6	patients	patient	NNS
cord-022594-fx044gcd	1061	7	may	may	MD
cord-022594-fx044gcd	1061	8	be	be	VB
cord-022594-fx044gcd	1061	9	as	as	RB
cord-022594-fx044gcd	1061	10	high	high	JJ
cord-022594-fx044gcd	1061	11	as	as	IN
cord-022594-fx044gcd	1061	12	two	two	CD
cord-022594-fx044gcd	1061	13	to	to	TO
cord-022594-fx044gcd	1061	14	seven	seven	CD
cord-022594-fx044gcd	1061	15	times	time	NNS
cord-022594-fx044gcd	1061	16	that	that	DT
cord-022594-fx044gcd	1061	17	of	of	IN
cord-022594-fx044gcd	1061	18	non	non	JJ
cord-022594-fx044gcd	1061	19	-	-	JJ
cord-022594-fx044gcd	1061	20	MS	MS	NNP
cord-022594-fx044gcd	1061	21	persons	person	NNS
cord-022594-fx044gcd	1061	22	.	.	.
cord-022594-fx044gcd	1062	1	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	1062	2	optica	optica	NN
cord-022594-fx044gcd	1062	3	(	(	-LRB-
cord-022594-fx044gcd	1062	4	NMO	NMO	NNP
cord-022594-fx044gcd	1062	5	)	)	-RRB-
cord-022594-fx044gcd	1062	6	is	be	VBZ
cord-022594-fx044gcd	1062	7	an	an	DT
cord-022594-fx044gcd	1062	8	uncommon	uncommon	JJ
cord-022594-fx044gcd	1062	9	neurological	neurological	JJ
cord-022594-fx044gcd	1062	10	illness	illness	NN
cord-022594-fx044gcd	1062	11	characterized	characterize	VBN
cord-022594-fx044gcd	1062	12	by	by	IN
cord-022594-fx044gcd	1062	13	the	the	DT
cord-022594-fx044gcd	1062	14	occurrence	occurrence	NN
cord-022594-fx044gcd	1062	15	of	of	IN
cord-022594-fx044gcd	1062	16	optic	optic	JJ
cord-022594-fx044gcd	1062	17	neuritis	neuritis	NN
cord-022594-fx044gcd	1062	18	and	and	CC
cord-022594-fx044gcd	1062	19	myelitis	myelitis	NNP
cord-022594-fx044gcd	1062	20	.	.	.
cord-022594-fx044gcd	1063	1	The	the	DT
cord-022594-fx044gcd	1063	2	names	name	NNS
cord-022594-fx044gcd	1063	3	Devic	Devic	NNP
cord-022594-fx044gcd	1063	4	's	's	POS
cord-022594-fx044gcd	1063	5	syndrome	syndrome	NN
cord-022594-fx044gcd	1063	6	,	,	,
cord-022594-fx044gcd	1063	7	Devic	Devic	NNP
cord-022594-fx044gcd	1063	8	's	's	POS
cord-022594-fx044gcd	1063	9	disease	disease	NN
cord-022594-fx044gcd	1063	10	,	,	,
cord-022594-fx044gcd	1063	11	and	and	CC
cord-022594-fx044gcd	1063	12	NMO	NMO	NNP
cord-022594-fx044gcd	1063	13	are	be	VBP
cord-022594-fx044gcd	1063	14	often	often	RB
cord-022594-fx044gcd	1063	15	used	use	VBN
cord-022594-fx044gcd	1063	16	interchangeably	interchangeably	RB
cord-022594-fx044gcd	1063	17	,	,	,
cord-022594-fx044gcd	1063	18	although	although	IN
cord-022594-fx044gcd	1063	19	the	the	DT
cord-022594-fx044gcd	1063	20	first	first	JJ
cord-022594-fx044gcd	1063	21	name	name	NN
cord-022594-fx044gcd	1063	22	encompasses	encompass	VBZ
cord-022594-fx044gcd	1063	23	all	all	DT
cord-022594-fx044gcd	1063	24	patients	patient	NNS
cord-022594-fx044gcd	1063	25	who	who	WP
cord-022594-fx044gcd	1063	26	fit	fit	VBP
cord-022594-fx044gcd	1063	27	the	the	DT
cord-022594-fx044gcd	1063	28	preceding	precede	VBG
cord-022594-fx044gcd	1063	29	definition	definition	NN
cord-022594-fx044gcd	1063	30	and	and	CC
cord-022594-fx044gcd	1063	31	the	the	DT
cord-022594-fx044gcd	1063	32	second	second	JJ
cord-022594-fx044gcd	1063	33	and	and	CC
cord-022594-fx044gcd	1063	34	third	third	RB
cord-022594-fx044gcd	1063	35	should	should	MD
cord-022594-fx044gcd	1063	36	only	only	RB
cord-022594-fx044gcd	1063	37	be	be	VB
cord-022594-fx044gcd	1063	38	used	use	VBN
cord-022594-fx044gcd	1063	39	to	to	TO
cord-022594-fx044gcd	1063	40	refer	refer	VB
cord-022594-fx044gcd	1063	41	to	to	IN
cord-022594-fx044gcd	1063	42	those	those	DT
cord-022594-fx044gcd	1063	43	patients	patient	NNS
cord-022594-fx044gcd	1063	44	presumed	presume	VBN
cord-022594-fx044gcd	1063	45	to	to	TO
cord-022594-fx044gcd	1063	46	have	have	VB
cord-022594-fx044gcd	1063	47	a	a	DT
cord-022594-fx044gcd	1063	48	distinct	distinct	JJ
cord-022594-fx044gcd	1063	49	disorder	disorder	NN
cord-022594-fx044gcd	1063	50	.	.	.
cord-022594-fx044gcd	1064	1	The	the	DT
cord-022594-fx044gcd	1064	2	term	term	NN
cord-022594-fx044gcd	1064	3	opticospinal	opticospinal	JJ
cord-022594-fx044gcd	1064	4	MS	MS	NNP
cord-022594-fx044gcd	1064	5	is	be	VBZ
cord-022594-fx044gcd	1064	6	often	often	RB
cord-022594-fx044gcd	1064	7	used	use	VBN
cord-022594-fx044gcd	1064	8	in	in	IN
cord-022594-fx044gcd	1064	9	the	the	DT
cord-022594-fx044gcd	1064	10	Far	Far	NNP
cord-022594-fx044gcd	1064	11	East	East	NNP
cord-022594-fx044gcd	1064	12	to	to	TO
cord-022594-fx044gcd	1064	13	denote	denote	VB
cord-022594-fx044gcd	1064	14	patients	patient	NNS
cord-022594-fx044gcd	1064	15	with	with	IN
cord-022594-fx044gcd	1064	16	exclusive	exclusive	JJ
cord-022594-fx044gcd	1064	17	or	or	CC
cord-022594-fx044gcd	1064	18	predominant	predominant	JJ
cord-022594-fx044gcd	1064	19	involvement	involvement	NN
cord-022594-fx044gcd	1064	20	of	of	IN
cord-022594-fx044gcd	1064	21	optic	optic	JJ
cord-022594-fx044gcd	1064	22	nerves	nerve	NNS
cord-022594-fx044gcd	1064	23	and	and	CC
cord-022594-fx044gcd	1064	24	spinal	spinal	JJ
cord-022594-fx044gcd	1064	25	cord	cord	NN
cord-022594-fx044gcd	1064	26	,	,	,
cord-022594-fx044gcd	1064	27	encompassing	encompass	VBG
cord-022594-fx044gcd	1064	28	most	most	JJS
cord-022594-fx044gcd	1064	29	patients	patient	NNS
cord-022594-fx044gcd	1064	30	with	with	IN
cord-022594-fx044gcd	1064	31	Devic	Devic	NNP
cord-022594-fx044gcd	1064	32	's	's	POS
cord-022594-fx044gcd	1064	33	syndrome	syndrome	NN
cord-022594-fx044gcd	1064	34	.	.	.
cord-022594-fx044gcd	1065	1	Devic	Devic	NNP
cord-022594-fx044gcd	1065	2	's	's	POS
cord-022594-fx044gcd	1065	3	disease	disease	NN
cord-022594-fx044gcd	1065	4	(	(	-LRB-
cord-022594-fx044gcd	1065	5	NMO	NMO	NNP
cord-022594-fx044gcd	1065	6	)	)	-RRB-
cord-022594-fx044gcd	1065	7	may	may	MD
cord-022594-fx044gcd	1065	8	be	be	VB
cord-022594-fx044gcd	1065	9	a	a	DT
cord-022594-fx044gcd	1065	10	monophasic	monophasic	JJ
cord-022594-fx044gcd	1065	11	illness	illness	NN
cord-022594-fx044gcd	1065	12	,	,	,
cord-022594-fx044gcd	1065	13	or	or	CC
cord-022594-fx044gcd	1065	14	may	may	MD
cord-022594-fx044gcd	1065	15	show	show	VB
cord-022594-fx044gcd	1065	16	a	a	DT
cord-022594-fx044gcd	1065	17	relapsingremitting	relapsingremitting	NN
cord-022594-fx044gcd	1065	18	course	course	NN
cord-022594-fx044gcd	1065	19	.	.	.
cord-022594-fx044gcd	1066	1	115	115	CD
cord-022594-fx044gcd	1067	1	It	-PRON-	PRP
cord-022594-fx044gcd	1067	2	is	be	VBZ
cord-022594-fx044gcd	1067	3	the	the	DT
cord-022594-fx044gcd	1067	4	first	first	JJ
cord-022594-fx044gcd	1067	5	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1067	6	demyelinating	demyelinating	NN
cord-022594-fx044gcd	1067	7	disease	disease	NN
cord-022594-fx044gcd	1067	8	with	with	IN
cord-022594-fx044gcd	1067	9	a	a	DT
cord-022594-fx044gcd	1067	10	known	know	VBN
cord-022594-fx044gcd	1067	11	serum	serum	NN
cord-022594-fx044gcd	1067	12	marker	marker	NN
cord-022594-fx044gcd	1067	13	,	,	,
cord-022594-fx044gcd	1067	14	the	the	DT
cord-022594-fx044gcd	1067	15	NMO	NMO	NNP
cord-022594-fx044gcd	1067	16	-	-	HYPH
cord-022594-fx044gcd	1067	17	IgG	IgG	NNP
cord-022594-fx044gcd	1067	18	antibody	antibody	NN
cord-022594-fx044gcd	1067	19	.	.	.
cord-022594-fx044gcd	1068	1	PATHOGENESIS	PATHOGENESIS	NNP
cord-022594-fx044gcd	1068	2	AND	and	CC
cord-022594-fx044gcd	1068	3	PATHOPHYSIOLOGY	PATHOPHYSIOLOGY	NNP
cord-022594-fx044gcd	1068	4	.	.	.
cord-022594-fx044gcd	1069	1	Devic	Devic	NNP
cord-022594-fx044gcd	1069	2	's	's	POS
cord-022594-fx044gcd	1069	3	syndrome	syndrome	NN
cord-022594-fx044gcd	1069	4	may	may	MD
cord-022594-fx044gcd	1069	5	occur	occur	VB
cord-022594-fx044gcd	1069	6	with	with	IN
cord-022594-fx044gcd	1069	7	ADEM	ADEM	NNP
cord-022594-fx044gcd	1069	8	,	,	,
cord-022594-fx044gcd	1069	9	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1069	10	disorders	disorder	NNS
cord-022594-fx044gcd	1069	11	(	(	-LRB-
cord-022594-fx044gcd	1069	12	e.g.	e.g.	RB
cord-022594-fx044gcd	1069	13	,	,	,
cord-022594-fx044gcd	1069	14	systemic	systemic	JJ
cord-022594-fx044gcd	1069	15	lupus	lupus	NN
cord-022594-fx044gcd	1069	16	erythematosus	erythematosus	NN
cord-022594-fx044gcd	1069	17	)	)	-RRB-
cord-022594-fx044gcd	1069	18	,	,	,
cord-022594-fx044gcd	1069	19	MS	MS	NNP
cord-022594-fx044gcd	1069	20	,	,	,
cord-022594-fx044gcd	1069	21	and	and	CC
cord-022594-fx044gcd	1069	22	possibly	possibly	RB
cord-022594-fx044gcd	1069	23	viral	viral	JJ
cord-022594-fx044gcd	1069	24	infections	infection	NNS
cord-022594-fx044gcd	1069	25	.	.	.
cord-022594-fx044gcd	1070	1	Also	also	RB
cord-022594-fx044gcd	1070	2	,	,	,
cord-022594-fx044gcd	1070	3	patients	patient	NNS
cord-022594-fx044gcd	1070	4	with	with	IN
cord-022594-fx044gcd	1070	5	Devic	Devic	NNP
cord-022594-fx044gcd	1070	6	's	's	POS
cord-022594-fx044gcd	1070	7	disease	disease	NN
cord-022594-fx044gcd	1070	8	may	may	MD
cord-022594-fx044gcd	1070	9	have	have	VB
cord-022594-fx044gcd	1070	10	other	other	JJ
cord-022594-fx044gcd	1070	11	coexisting	coexist	VBG
cord-022594-fx044gcd	1070	12	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1070	13	conditions	condition	NNS
cord-022594-fx044gcd	1070	14	.	.	.
cord-022594-fx044gcd	1071	1	Classically	classically	RB
cord-022594-fx044gcd	1071	2	,	,	,
cord-022594-fx044gcd	1071	3	acute	acute	JJ
cord-022594-fx044gcd	1071	4	spinal	spinal	JJ
cord-022594-fx044gcd	1071	5	cord	cord	NN
cord-022594-fx044gcd	1071	6	lesions	lesion	NNS
cord-022594-fx044gcd	1071	7	demonstrate	demonstrate	VBP
cord-022594-fx044gcd	1071	8	diffuse	diffuse	JJ
cord-022594-fx044gcd	1071	9	swelling	swelling	NN
cord-022594-fx044gcd	1071	10	that	that	WDT
cord-022594-fx044gcd	1071	11	extend	extend	VBP
cord-022594-fx044gcd	1071	12	over	over	IN
cord-022594-fx044gcd	1071	13	several	several	JJ
cord-022594-fx044gcd	1071	14	levels	level	NNS
cord-022594-fx044gcd	1071	15	or	or	CC
cord-022594-fx044gcd	1071	16	involve	involve	VBP
cord-022594-fx044gcd	1071	17	nearly	nearly	RB
cord-022594-fx044gcd	1071	18	the	the	DT
cord-022594-fx044gcd	1071	19	entire	entire	JJ
cord-022594-fx044gcd	1071	20	cross	cross	NN
cord-022594-fx044gcd	1071	21	section	section	NN
cord-022594-fx044gcd	1071	22	of	of	IN
cord-022594-fx044gcd	1071	23	the	the	DT
cord-022594-fx044gcd	1071	24	cord	cord	NN
cord-022594-fx044gcd	1071	25	.	.	.
cord-022594-fx044gcd	1072	1	Acutely	acutely	RB
cord-022594-fx044gcd	1072	2	,	,	,
cord-022594-fx044gcd	1072	3	there	there	EX
cord-022594-fx044gcd	1072	4	is	be	VBZ
cord-022594-fx044gcd	1072	5	destruction	destruction	NN
cord-022594-fx044gcd	1072	6	with	with	IN
cord-022594-fx044gcd	1072	7	dense	dense	JJ
cord-022594-fx044gcd	1072	8	macrophage	macrophage	NN
cord-022594-fx044gcd	1072	9	infiltration	infiltration	NN
cord-022594-fx044gcd	1072	10	involving	involve	VBG
cord-022594-fx044gcd	1072	11	white	white	JJ
cord-022594-fx044gcd	1072	12	and	and	CC
cord-022594-fx044gcd	1072	13	gray	gray	JJ
cord-022594-fx044gcd	1072	14	matter	matter	NN
cord-022594-fx044gcd	1072	15	,	,	,
cord-022594-fx044gcd	1072	16	loss	loss	NN
cord-022594-fx044gcd	1072	17	of	of	IN
cord-022594-fx044gcd	1072	18	myelin	myelin	NN
cord-022594-fx044gcd	1072	19	and	and	CC
cord-022594-fx044gcd	1072	20	axons	axon	NNS
cord-022594-fx044gcd	1072	21	,	,	,
cord-022594-fx044gcd	1072	22	and	and	CC
cord-022594-fx044gcd	1072	23	lymphocytic	lymphocytic	JJ
cord-022594-fx044gcd	1072	24	cuffing	cuffing	NN
cord-022594-fx044gcd	1072	25	of	of	IN
cord-022594-fx044gcd	1072	26	vessels	vessel	NNS
cord-022594-fx044gcd	1072	27	.	.	.
cord-022594-fx044gcd	1073	1	In	in	IN
cord-022594-fx044gcd	1073	2	chronic	chronic	JJ
cord-022594-fx044gcd	1073	3	lesions	lesion	NNS
cord-022594-fx044gcd	1073	4	,	,	,
cord-022594-fx044gcd	1073	5	the	the	DT
cord-022594-fx044gcd	1073	6	cord	cord	NN
cord-022594-fx044gcd	1073	7	is	be	VBZ
cord-022594-fx044gcd	1073	8	atrophic	atrophic	JJ
cord-022594-fx044gcd	1073	9	and	and	CC
cord-022594-fx044gcd	1073	10	necrotic	necrotic	JJ
cord-022594-fx044gcd	1073	11	,	,	,
cord-022594-fx044gcd	1073	12	occasionally	occasionally	RB
cord-022594-fx044gcd	1073	13	with	with	IN
cord-022594-fx044gcd	1073	14	cystic	cystic	JJ
cord-022594-fx044gcd	1073	15	degeneration	degeneration	NN
cord-022594-fx044gcd	1073	16	and	and	CC
cord-022594-fx044gcd	1073	17	gliosis	gliosis	NNP
cord-022594-fx044gcd	1073	18	.	.	.
cord-022594-fx044gcd	1074	1	In	in	IN
cord-022594-fx044gcd	1074	2	the	the	DT
cord-022594-fx044gcd	1074	3	absence	absence	NN
cord-022594-fx044gcd	1074	4	of	of	IN
cord-022594-fx044gcd	1074	5	perivascular	perivascular	JJ
cord-022594-fx044gcd	1074	6	cuffing	cuffing	NN
cord-022594-fx044gcd	1074	7	,	,	,
cord-022594-fx044gcd	1074	8	these	these	DT
cord-022594-fx044gcd	1074	9	extensive	extensive	JJ
cord-022594-fx044gcd	1074	10	lesions	lesion	NNS
cord-022594-fx044gcd	1074	11	resemble	resemble	VBP
cord-022594-fx044gcd	1074	12	infarctions	infarction	NNS
cord-022594-fx044gcd	1074	13	.	.	.
cord-022594-fx044gcd	1075	1	The	the	DT
cord-022594-fx044gcd	1075	2	prominent	prominent	JJ
cord-022594-fx044gcd	1075	3	spinal	spinal	JJ
cord-022594-fx044gcd	1075	4	cord	cord	NN
cord-022594-fx044gcd	1075	5	swelling	swell	VBG
cord-022594-fx044gcd	1075	6	in	in	IN
cord-022594-fx044gcd	1075	7	the	the	DT
cord-022594-fx044gcd	1075	8	confines	confine	NNS
cord-022594-fx044gcd	1075	9	of	of	IN
cord-022594-fx044gcd	1075	10	the	the	DT
cord-022594-fx044gcd	1075	11	restrictive	restrictive	JJ
cord-022594-fx044gcd	1075	12	pia	pia	NN
cord-022594-fx044gcd	1075	13	presumably	presumably	RB
cord-022594-fx044gcd	1075	14	may	may	MD
cord-022594-fx044gcd	1075	15	raise	raise	VB
cord-022594-fx044gcd	1075	16	intramedullary	intramedullary	JJ
cord-022594-fx044gcd	1075	17	pressure	pressure	NN
cord-022594-fx044gcd	1075	18	,	,	,
cord-022594-fx044gcd	1075	19	leading	lead	VBG
cord-022594-fx044gcd	1075	20	to	to	IN
cord-022594-fx044gcd	1075	21	the	the	DT
cord-022594-fx044gcd	1075	22	collapse	collapse	NN
cord-022594-fx044gcd	1075	23	of	of	IN
cord-022594-fx044gcd	1075	24	small	small	JJ
cord-022594-fx044gcd	1075	25	parenchymal	parenchymal	JJ
cord-022594-fx044gcd	1075	26	vessels	vessel	NNS
cord-022594-fx044gcd	1075	27	,	,	,
cord-022594-fx044gcd	1075	28	further	further	RB
cord-022594-fx044gcd	1075	29	propagating	propagate	VBG
cord-022594-fx044gcd	1075	30	tissue	tissue	NN
cord-022594-fx044gcd	1075	31	injury	injury	NN
cord-022594-fx044gcd	1075	32	.	.	.
cord-022594-fx044gcd	1076	1	Proliferation	proliferation	NN
cord-022594-fx044gcd	1076	2	of	of	IN
cord-022594-fx044gcd	1076	3	vessels	vessel	NNS
cord-022594-fx044gcd	1076	4	with	with	IN
cord-022594-fx044gcd	1076	5	thickened	thickened	JJ
cord-022594-fx044gcd	1076	6	and	and	CC
cord-022594-fx044gcd	1076	7	hyalinized	hyalinize	VBN
cord-022594-fx044gcd	1076	8	walls	wall	NNS
cord-022594-fx044gcd	1076	9	similar	similar	JJ
cord-022594-fx044gcd	1076	10	to	to	IN
cord-022594-fx044gcd	1076	11	that	that	DT
cord-022594-fx044gcd	1076	12	seen	see	VBN
cord-022594-fx044gcd	1076	13	after	after	IN
cord-022594-fx044gcd	1076	14	infarction	infarction	NN
cord-022594-fx044gcd	1076	15	or	or	CC
cord-022594-fx044gcd	1076	16	other	other	JJ
cord-022594-fx044gcd	1076	17	extensive	extensive	JJ
cord-022594-fx044gcd	1076	18	injury	injury	NN
cord-022594-fx044gcd	1076	19	may	may	MD
cord-022594-fx044gcd	1076	20	occur	occur	VB
cord-022594-fx044gcd	1076	21	.	.	.
cord-022594-fx044gcd	1077	1	116	116	CD
cord-022594-fx044gcd	1077	2	Less	less	RBR
cord-022594-fx044gcd	1077	3	fulminant	fulminant	JJ
cord-022594-fx044gcd	1077	4	lesions	lesion	NNS
cord-022594-fx044gcd	1077	5	may	may	MD
cord-022594-fx044gcd	1077	6	coexist	coexist	VB
cord-022594-fx044gcd	1077	7	and	and	CC
cord-022594-fx044gcd	1077	8	are	be	VBP
cord-022594-fx044gcd	1077	9	much	much	RB
cord-022594-fx044gcd	1077	10	more	more	RBR
cord-022594-fx044gcd	1077	11	typical	typical	JJ
cord-022594-fx044gcd	1077	12	of	of	IN
cord-022594-fx044gcd	1077	13	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1077	14	demyelination	demyelination	NN
cord-022594-fx044gcd	1077	15	.	.	.
cord-022594-fx044gcd	1078	1	The	the	DT
cord-022594-fx044gcd	1078	2	optic	optic	JJ
cord-022594-fx044gcd	1078	3	nerve	nerve	NN
cord-022594-fx044gcd	1078	4	lesions	lesion	NNS
cord-022594-fx044gcd	1078	5	often	often	RB
cord-022594-fx044gcd	1078	6	involve	involve	VBP
cord-022594-fx044gcd	1078	7	the	the	DT
cord-022594-fx044gcd	1078	8	chiasm	chiasm	NN
cord-022594-fx044gcd	1078	9	.	.	.
cord-022594-fx044gcd	1079	1	Even	even	RB
cord-022594-fx044gcd	1079	2	though	though	IN
cord-022594-fx044gcd	1079	3	NMO	NMO	NNP
cord-022594-fx044gcd	1079	4	is	be	VBZ
cord-022594-fx044gcd	1079	5	usually	usually	RB
cord-022594-fx044gcd	1079	6	restricted	restrict	VBN
cord-022594-fx044gcd	1079	7	to	to	IN
cord-022594-fx044gcd	1079	8	the	the	DT
cord-022594-fx044gcd	1079	9	optic	optic	JJ
cord-022594-fx044gcd	1079	10	nerves	nerve	NNS
cord-022594-fx044gcd	1079	11	and	and	CC
cord-022594-fx044gcd	1079	12	spinal	spinal	JJ
cord-022594-fx044gcd	1079	13	cord	cord	NN
cord-022594-fx044gcd	1079	14	,	,	,
cord-022594-fx044gcd	1079	15	one	one	PRP
cord-022594-fx044gcd	1079	16	may	may	MD
cord-022594-fx044gcd	1079	17	see	see	VB
cord-022594-fx044gcd	1079	18	classic	classic	JJ
cord-022594-fx044gcd	1079	19	MS	MS	NNP
cord-022594-fx044gcd	1079	20	like	like	IN
cord-022594-fx044gcd	1079	21	lesions	lesion	NNS
cord-022594-fx044gcd	1079	22	in	in	IN
cord-022594-fx044gcd	1079	23	up	up	IN
cord-022594-fx044gcd	1079	24	to	to	TO
cord-022594-fx044gcd	1079	25	10	10	CD
cord-022594-fx044gcd	1079	26	%	%	NN
cord-022594-fx044gcd	1079	27	of	of	IN
cord-022594-fx044gcd	1079	28	cases	case	NNS
cord-022594-fx044gcd	1079	29	,	,	,
cord-022594-fx044gcd	1079	30	and	and	CC
cord-022594-fx044gcd	1079	31	hypothalamic	hypothalamic	JJ
cord-022594-fx044gcd	1079	32	lesions	lesion	NNS
cord-022594-fx044gcd	1079	33	have	have	VBP
cord-022594-fx044gcd	1079	34	also	also	RB
cord-022594-fx044gcd	1079	35	been	be	VBN
cord-022594-fx044gcd	1079	36	described	describe	VBN
cord-022594-fx044gcd	1079	37	in	in	IN
cord-022594-fx044gcd	1079	38	approximately	approximately	RB
cord-022594-fx044gcd	1079	39	10	10	CD
cord-022594-fx044gcd	1079	40	%	%	NN
cord-022594-fx044gcd	1079	41	.	.	.
cord-022594-fx044gcd	1080	1	The	the	DT
cord-022594-fx044gcd	1080	2	newly	newly	RB
cord-022594-fx044gcd	1080	3	discovered	discover	VBN
cord-022594-fx044gcd	1080	4	serum	serum	NN
cord-022594-fx044gcd	1080	5	marker	marker	NN
cord-022594-fx044gcd	1080	6	,	,	,
cord-022594-fx044gcd	1080	7	NMO	NMO	NNP
cord-022594-fx044gcd	1080	8	-	-	HYPH
cord-022594-fx044gcd	1080	9	IgG	IgG	NNP
cord-022594-fx044gcd	1080	10	has	have	VBZ
cord-022594-fx044gcd	1080	11	a	a	DT
cord-022594-fx044gcd	1080	12	sensitivity	sensitivity	NN
cord-022594-fx044gcd	1080	13	of	of	IN
cord-022594-fx044gcd	1080	14	73	73	CD
cord-022594-fx044gcd	1080	15	%	%	NN
cord-022594-fx044gcd	1080	16	and	and	CC
cord-022594-fx044gcd	1080	17	specificity	specificity	NN
cord-022594-fx044gcd	1080	18	of	of	IN
cord-022594-fx044gcd	1080	19	91	91	CD
cord-022594-fx044gcd	1080	20	%	%	NN
cord-022594-fx044gcd	1080	21	.	.	.
cord-022594-fx044gcd	1081	1	117	117	CD
cord-022594-fx044gcd	1082	1	The	the	DT
cord-022594-fx044gcd	1082	2	discovery	discovery	NN
cord-022594-fx044gcd	1082	3	of	of	IN
cord-022594-fx044gcd	1082	4	this	this	DT
cord-022594-fx044gcd	1082	5	novel	novel	JJ
cord-022594-fx044gcd	1082	6	immune	immune	NN
cord-022594-fx044gcd	1082	7	marker	marker	NN
cord-022594-fx044gcd	1082	8	also	also	RB
cord-022594-fx044gcd	1082	9	clarified	clarify	VBD
cord-022594-fx044gcd	1082	10	that	that	IN
cord-022594-fx044gcd	1082	11	most	most	JJS
cord-022594-fx044gcd	1082	12	if	if	IN
cord-022594-fx044gcd	1082	13	not	not	RB
cord-022594-fx044gcd	1082	14	all	all	DT
cord-022594-fx044gcd	1082	15	cases	case	NNS
cord-022594-fx044gcd	1082	16	of	of	IN
cord-022594-fx044gcd	1082	17	"	"	``
cord-022594-fx044gcd	1082	18	opticospinal	opticospinal	JJ
cord-022594-fx044gcd	1082	19	MS	MS	NNP
cord-022594-fx044gcd	1082	20	"	"	''
cord-022594-fx044gcd	1082	21	reported	report	VBN
cord-022594-fx044gcd	1082	22	in	in	IN
cord-022594-fx044gcd	1082	23	the	the	DT
cord-022594-fx044gcd	1082	24	Japanese	japanese	JJ
cord-022594-fx044gcd	1082	25	literature	literature	NN
cord-022594-fx044gcd	1082	26	are	be	VBP
cord-022594-fx044gcd	1082	27	also	also	RB
cord-022594-fx044gcd	1082	28	cases	case	NNS
cord-022594-fx044gcd	1082	29	of	of	IN
cord-022594-fx044gcd	1082	30	NMO	NMO	NNP
cord-022594-fx044gcd	1082	31	.	.	.
cord-022594-fx044gcd	1083	1	To	to	IN
cord-022594-fx044gcd	1083	2	the	the	DT
cord-022594-fx044gcd	1083	3	surprise	surprise	NN
cord-022594-fx044gcd	1083	4	of	of	IN
cord-022594-fx044gcd	1083	5	the	the	DT
cord-022594-fx044gcd	1083	6	MS	MS	NNP
cord-022594-fx044gcd	1083	7	research	research	NN
cord-022594-fx044gcd	1083	8	community	community	NN
cord-022594-fx044gcd	1083	9	,	,	,
cord-022594-fx044gcd	1083	10	the	the	DT
cord-022594-fx044gcd	1083	11	antigen	antigen	NN
cord-022594-fx044gcd	1083	12	is	be	VBZ
cord-022594-fx044gcd	1083	13	neither	neither	CC
cord-022594-fx044gcd	1083	14	myelin	myelin	JJ
cord-022594-fx044gcd	1083	15	nor	nor	CC
cord-022594-fx044gcd	1083	16	neuron	neuron	NN
cord-022594-fx044gcd	1083	17	related	relate	VBN
cord-022594-fx044gcd	1083	18	:	:	:
cord-022594-fx044gcd	1083	19	it	-PRON-	PRP
cord-022594-fx044gcd	1083	20	is	be	VBZ
cord-022594-fx044gcd	1083	21	the	the	DT
cord-022594-fx044gcd	1083	22	aquaporin-4	aquaporin-4	NNP
cord-022594-fx044gcd	1083	23	water	water	NN
cord-022594-fx044gcd	1083	24	channel	channel	NNP
cord-022594-fx044gcd	1083	25	,	,	,
cord-022594-fx044gcd	1083	26	a	a	DT
cord-022594-fx044gcd	1083	27	component	component	NN
cord-022594-fx044gcd	1083	28	of	of	IN
cord-022594-fx044gcd	1083	29	the	the	DT
cord-022594-fx044gcd	1083	30	dystroglycan	dystroglycan	NNP
cord-022594-fx044gcd	1083	31	protein	protein	NNP
cord-022594-fx044gcd	1083	32	complex	complex	NN
cord-022594-fx044gcd	1083	33	located	locate	VBN
cord-022594-fx044gcd	1083	34	in	in	IN
cord-022594-fx044gcd	1083	35	astrocytic	astrocytic	JJ
cord-022594-fx044gcd	1083	36	foot	foot	NN
cord-022594-fx044gcd	1083	37	processes	process	NNS
cord-022594-fx044gcd	1083	38	at	at	IN
cord-022594-fx044gcd	1083	39	the	the	DT
cord-022594-fx044gcd	1083	40	bloodbrain	bloodbrain	NN
cord-022594-fx044gcd	1083	41	barrier	barrier	NN
cord-022594-fx044gcd	1083	42	.	.	.
cord-022594-fx044gcd	1084	1	11	11	CD
cord-022594-fx044gcd	1084	2	NMO	NMO	NNP
cord-022594-fx044gcd	1084	3	thus	thus	RB
cord-022594-fx044gcd	1084	4	may	may	MD
cord-022594-fx044gcd	1084	5	represent	represent	VB
cord-022594-fx044gcd	1084	6	the	the	DT
cord-022594-fx044gcd	1084	7	first	first	JJ
cord-022594-fx044gcd	1084	8	example	example	NN
cord-022594-fx044gcd	1084	9	of	of	IN
cord-022594-fx044gcd	1084	10	a	a	DT
cord-022594-fx044gcd	1084	11	novel	novel	JJ
cord-022594-fx044gcd	1084	12	class	class	NN
cord-022594-fx044gcd	1084	13	of	of	IN
cord-022594-fx044gcd	1084	14	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1084	15	channelopathies	channelopathie	NNS
cord-022594-fx044gcd	1084	16	.	.	.
cord-022594-fx044gcd	1085	1	EPIDEMIOLOGY	EPIDEMIOLOGY	NNP
cord-022594-fx044gcd	1085	2	AND	and	CC
cord-022594-fx044gcd	1085	3	RISK	risk	NN
cord-022594-fx044gcd	1085	4	FACTORS	factors	NN
cord-022594-fx044gcd	1085	5	.	.	.
cord-022594-fx044gcd	1086	1	Devic	Devic	NNP
cord-022594-fx044gcd	1086	2	's	's	POS
cord-022594-fx044gcd	1086	3	syndrome	syndrome	NN
cord-022594-fx044gcd	1086	4	occurs	occur	VBZ
cord-022594-fx044gcd	1086	5	in	in	IN
cord-022594-fx044gcd	1086	6	patients	patient	NNS
cord-022594-fx044gcd	1086	7	of	of	IN
cord-022594-fx044gcd	1086	8	varied	varied	JJ
cord-022594-fx044gcd	1086	9	ages	age	NNS
cord-022594-fx044gcd	1086	10	(	(	-LRB-
cord-022594-fx044gcd	1086	11	range	range	NN
cord-022594-fx044gcd	1086	12	,	,	,
cord-022594-fx044gcd	1086	13	1	1	CD
cord-022594-fx044gcd	1086	14	to	to	IN
cord-022594-fx044gcd	1086	15	73	73	CD
cord-022594-fx044gcd	1086	16	years	year	NNS
cord-022594-fx044gcd	1086	17	)	)	-RRB-
cord-022594-fx044gcd	1086	18	.	.	.
cord-022594-fx044gcd	1087	1	The	the	DT
cord-022594-fx044gcd	1087	2	mean	mean	JJ
cord-022594-fx044gcd	1087	3	age	age	NN
cord-022594-fx044gcd	1087	4	at	at	IN
cord-022594-fx044gcd	1087	5	onset	onset	NN
cord-022594-fx044gcd	1087	6	of	of	IN
cord-022594-fx044gcd	1087	7	monophasic	monophasic	JJ
cord-022594-fx044gcd	1087	8	Devic	Devic	NNP
cord-022594-fx044gcd	1087	9	's	's	POS
cord-022594-fx044gcd	1087	10	syndrome	syndrome	NN
cord-022594-fx044gcd	1087	11	is	be	VBZ
cord-022594-fx044gcd	1087	12	27	27	CD
cord-022594-fx044gcd	1087	13	,	,	,
cord-022594-fx044gcd	1087	14	whereas	whereas	IN
cord-022594-fx044gcd	1087	15	relapsing	relapse	VBG
cord-022594-fx044gcd	1087	16	NMO	NMO	NNP
cord-022594-fx044gcd	1087	17	(	(	-LRB-
cord-022594-fx044gcd	1087	18	see	see	VB
cord-022594-fx044gcd	1087	19	later	later	RBR
cord-022594-fx044gcd	1087	20	)	)	-RRB-
cord-022594-fx044gcd	1087	21	tends	tend	VBZ
cord-022594-fx044gcd	1087	22	to	to	TO
cord-022594-fx044gcd	1087	23	occur	occur	VB
cord-022594-fx044gcd	1087	24	in	in	IN
cord-022594-fx044gcd	1087	25	an	an	DT
cord-022594-fx044gcd	1087	26	older	old	JJR
cord-022594-fx044gcd	1087	27	age	age	NN
cord-022594-fx044gcd	1087	28	group	group	NN
cord-022594-fx044gcd	1087	29	(	(	-LRB-
cord-022594-fx044gcd	1087	30	mean	mean	JJ
cord-022594-fx044gcd	1087	31	age	age	NN
cord-022594-fx044gcd	1087	32	at	at	IN
cord-022594-fx044gcd	1087	33	onset	onset	NN
cord-022594-fx044gcd	1087	34	of	of	IN
cord-022594-fx044gcd	1087	35	43	43	CD
cord-022594-fx044gcd	1087	36	)	)	-RRB-
cord-022594-fx044gcd	1087	37	.	.	.
cord-022594-fx044gcd	1088	1	Monophasic	Monophasic	NNP
cord-022594-fx044gcd	1088	2	Devic	Devic	NNP
cord-022594-fx044gcd	1088	3	's	's	POS
cord-022594-fx044gcd	1088	4	syndrome	syndrome	NN
cord-022594-fx044gcd	1088	5	affects	affect	VBZ
cord-022594-fx044gcd	1088	6	males	male	NNS
cord-022594-fx044gcd	1088	7	and	and	CC
cord-022594-fx044gcd	1088	8	females	female	NNS
cord-022594-fx044gcd	1088	9	equally	equally	RB
cord-022594-fx044gcd	1088	10	,	,	,
cord-022594-fx044gcd	1088	11	whereas	whereas	IN
cord-022594-fx044gcd	1088	12	relapsing	relapse	VBG
cord-022594-fx044gcd	1088	13	NMO	NMO	NNP
cord-022594-fx044gcd	1088	14	affects	affect	VBZ
cord-022594-fx044gcd	1088	15	females	female	NNS
cord-022594-fx044gcd	1088	16	predominantly	predominantly	RB
cord-022594-fx044gcd	1088	17	(	(	-LRB-
cord-022594-fx044gcd	1088	18	F	f	NN
cord-022594-fx044gcd	1088	19	:	:	:
cord-022594-fx044gcd	1088	20	M	M	NNP
cord-022594-fx044gcd	1088	21	,	,	,
cord-022594-fx044gcd	1088	22	3.8:1	3.8:1	CD
cord-022594-fx044gcd	1088	23	)	)	-RRB-
cord-022594-fx044gcd	1088	24	.	.	.
cord-022594-fx044gcd	1089	1	One	one	CD
cord-022594-fx044gcd	1089	2	third	third	NN
cord-022594-fx044gcd	1089	3	of	of	IN
cord-022594-fx044gcd	1089	4	patients	patient	NNS
cord-022594-fx044gcd	1089	5	have	have	VBP
cord-022594-fx044gcd	1089	6	a	a	DT
cord-022594-fx044gcd	1089	7	preceding	precede	VBG
cord-022594-fx044gcd	1089	8	infection	infection	NN
cord-022594-fx044gcd	1089	9	within	within	IN
cord-022594-fx044gcd	1089	10	a	a	DT
cord-022594-fx044gcd	1089	11	few	few	JJ
cord-022594-fx044gcd	1089	12	weeks	week	NNS
cord-022594-fx044gcd	1089	13	of	of	IN
cord-022594-fx044gcd	1089	14	neurological	neurological	JJ
cord-022594-fx044gcd	1089	15	symptom	symptom	NN
cord-022594-fx044gcd	1089	16	onset	onset	NN
cord-022594-fx044gcd	1089	17	.	.	.
cord-022594-fx044gcd	1090	1	Most	most	RBS
cord-022594-fx044gcd	1090	2	commonly	commonly	RB
cord-022594-fx044gcd	1090	3	this	this	DT
cord-022594-fx044gcd	1090	4	is	be	VBZ
cord-022594-fx044gcd	1090	5	a	a	DT
cord-022594-fx044gcd	1090	6	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	1090	7	upper	upper	JJ
cord-022594-fx044gcd	1090	8	respiratory	respiratory	JJ
cord-022594-fx044gcd	1090	9	tract	tract	NN
cord-022594-fx044gcd	1090	10	infection	infection	NN
cord-022594-fx044gcd	1090	11	,	,	,
cord-022594-fx044gcd	1090	12	flu	flu	NN
cord-022594-fx044gcd	1090	13	,	,	,
cord-022594-fx044gcd	1090	14	or	or	CC
cord-022594-fx044gcd	1090	15	gastroenteritis	gastroenteritis	NN
cord-022594-fx044gcd	1090	16	.	.	.
cord-022594-fx044gcd	1091	1	The	the	DT
cord-022594-fx044gcd	1091	2	most	most	RBS
cord-022594-fx044gcd	1091	3	common	common	JJ
cord-022594-fx044gcd	1091	4	specific	specific	JJ
cord-022594-fx044gcd	1091	5	infections	infection	NNS
cord-022594-fx044gcd	1091	6	preceding	precede	VBG
cord-022594-fx044gcd	1091	7	the	the	DT
cord-022594-fx044gcd	1091	8	development	development	NN
cord-022594-fx044gcd	1091	9	of	of	IN
cord-022594-fx044gcd	1091	10	Devic	Devic	NNP
cord-022594-fx044gcd	1091	11	's	's	POS
cord-022594-fx044gcd	1091	12	syndrome	syndrome	NN
cord-022594-fx044gcd	1091	13	are	be	VBP
cord-022594-fx044gcd	1091	14	chickenpox	chickenpox	NN
cord-022594-fx044gcd	1091	15	and	and	CC
cord-022594-fx044gcd	1091	16	pulmonary	pulmonary	JJ
cord-022594-fx044gcd	1091	17	tuberculosis	tuberculosis	NN
cord-022594-fx044gcd	1091	18	.	.	.
cord-022594-fx044gcd	1092	1	Devic	Devic	NNP
cord-022594-fx044gcd	1092	2	's	's	POS
cord-022594-fx044gcd	1092	3	syndrome	syndrome	NN
cord-022594-fx044gcd	1092	4	has	have	VBZ
cord-022594-fx044gcd	1092	5	also	also	RB
cord-022594-fx044gcd	1092	6	followed	follow	VBN
cord-022594-fx044gcd	1092	7	vaccination	vaccination	NN
cord-022594-fx044gcd	1092	8	for	for	IN
cord-022594-fx044gcd	1092	9	swine	swine	NN
cord-022594-fx044gcd	1092	10	flu	flu	NN
cord-022594-fx044gcd	1092	11	and	and	CC
cord-022594-fx044gcd	1092	12	mumps	mumps	NN
cord-022594-fx044gcd	1092	13	.	.	.
cord-022594-fx044gcd	1093	1	Only	only	RB
cord-022594-fx044gcd	1093	2	a	a	DT
cord-022594-fx044gcd	1093	3	few	few	JJ
cord-022594-fx044gcd	1093	4	instances	instance	NNS
cord-022594-fx044gcd	1093	5	of	of	IN
cord-022594-fx044gcd	1093	6	a	a	DT
cord-022594-fx044gcd	1093	7	possible	possible	JJ
cord-022594-fx044gcd	1093	8	familial	familial	JJ
cord-022594-fx044gcd	1093	9	occurrence	occurrence	NN
cord-022594-fx044gcd	1093	10	of	of	IN
cord-022594-fx044gcd	1093	11	Devic	Devic	NNP
cord-022594-fx044gcd	1093	12	's	's	POS
cord-022594-fx044gcd	1093	13	syndrome	syndrome	NN
cord-022594-fx044gcd	1093	14	have	have	VBP
cord-022594-fx044gcd	1093	15	been	be	VBN
cord-022594-fx044gcd	1093	16	reported	report	VBN
cord-022594-fx044gcd	1093	17	,	,	,
cord-022594-fx044gcd	1093	18	and	and	CC
cord-022594-fx044gcd	1093	19	in	in	IN
cord-022594-fx044gcd	1093	20	one	one	CD
cord-022594-fx044gcd	1093	21	of	of	IN
cord-022594-fx044gcd	1093	22	these	these	DT
cord-022594-fx044gcd	1093	23	families	family	NNS
cord-022594-fx044gcd	1093	24	,	,	,
cord-022594-fx044gcd	1093	25	a	a	DT
cord-022594-fx044gcd	1093	26	unique	unique	JJ
cord-022594-fx044gcd	1093	27	mitochondrial	mitochondrial	JJ
cord-022594-fx044gcd	1093	28	mutation	mutation	NN
cord-022594-fx044gcd	1093	29	was	be	VBD
cord-022594-fx044gcd	1093	30	found	find	VBN
cord-022594-fx044gcd	1093	31	.	.	.
cord-022594-fx044gcd	1094	1	Devic	Devic	NNP
cord-022594-fx044gcd	1094	2	's	's	POS
cord-022594-fx044gcd	1094	3	syndrome	syndrome	NN
cord-022594-fx044gcd	1094	4	is	be	VBZ
cord-022594-fx044gcd	1094	5	said	say	VBN
cord-022594-fx044gcd	1094	6	to	to	TO
cord-022594-fx044gcd	1094	7	be	be	VB
cord-022594-fx044gcd	1094	8	more	more	RBR
cord-022594-fx044gcd	1094	9	common	common	JJ
cord-022594-fx044gcd	1094	10	in	in	IN
cord-022594-fx044gcd	1094	11	Japan	Japan	NNP
cord-022594-fx044gcd	1094	12	and	and	CC
cord-022594-fx044gcd	1094	13	East	East	NNP
cord-022594-fx044gcd	1094	14	Asia	Asia	NNP
cord-022594-fx044gcd	1094	15	,	,	,
cord-022594-fx044gcd	1094	16	although	although	IN
cord-022594-fx044gcd	1094	17	even	even	RB
cord-022594-fx044gcd	1094	18	there	there	EX
cord-022594-fx044gcd	1094	19	it	-PRON-	PRP
cord-022594-fx044gcd	1094	20	is	be	VBZ
cord-022594-fx044gcd	1094	21	uncommon	uncommon	JJ
cord-022594-fx044gcd	1094	22	(	(	-LRB-
cord-022594-fx044gcd	1094	23	less	less	JJR
cord-022594-fx044gcd	1094	24	than	than	IN
cord-022594-fx044gcd	1094	25	5	5	CD
cord-022594-fx044gcd	1094	26	per	per	IN
cord-022594-fx044gcd	1094	27	100,000	100,000	CD
cord-022594-fx044gcd	1094	28	)	)	-RRB-
cord-022594-fx044gcd	1094	29	.	.	.
cord-022594-fx044gcd	1095	1	Three	three	CD
cord-022594-fx044gcd	1095	2	cases	case	NNS
cord-022594-fx044gcd	1095	3	have	have	VBP
cord-022594-fx044gcd	1095	4	been	be	VBN
cord-022594-fx044gcd	1095	5	described	describe	VBN
cord-022594-fx044gcd	1095	6	in	in	IN
cord-022594-fx044gcd	1095	7	the	the	DT
cord-022594-fx044gcd	1095	8	literature	literature	NN
cord-022594-fx044gcd	1095	9	with	with	IN
cord-022594-fx044gcd	1095	10	familial	familial	JJ
cord-022594-fx044gcd	1095	11	occurrence	occurrence	NN
cord-022594-fx044gcd	1095	12	of	of	IN
cord-022594-fx044gcd	1095	13	Devic	Devic	NNP
cord-022594-fx044gcd	1095	14	's	's	POS
cord-022594-fx044gcd	1095	15	disease	disease	NN
cord-022594-fx044gcd	1095	16	in	in	IN
cord-022594-fx044gcd	1095	17	the	the	DT
cord-022594-fx044gcd	1095	18	Far	Far	NNP
cord-022594-fx044gcd	1095	19	East	East	NNP
cord-022594-fx044gcd	1095	20	.	.	.
cord-022594-fx044gcd	1096	1	In	in	IN
cord-022594-fx044gcd	1096	2	a	a	DT
cord-022594-fx044gcd	1096	3	genetic	genetic	JJ
cord-022594-fx044gcd	1096	4	study	study	NN
cord-022594-fx044gcd	1096	5	,	,	,
cord-022594-fx044gcd	1096	6	HLA	HLA	NNP
cord-022594-fx044gcd	1096	7	-	-	HYPH
cord-022594-fx044gcd	1096	8	DPB1	DPB1	NNP
cord-022594-fx044gcd	1096	9	*	*	NFP
cord-022594-fx044gcd	1096	10	0501	0501	CD
cord-022594-fx044gcd	1096	11	was	be	VBD
cord-022594-fx044gcd	1096	12	more	more	RBR
cord-022594-fx044gcd	1096	13	frequently	frequently	RB
cord-022594-fx044gcd	1096	14	associated	associate	VBN
cord-022594-fx044gcd	1096	15	with	with	IN
cord-022594-fx044gcd	1096	16	"	"	``
cord-022594-fx044gcd	1096	17	opticospinal	opticospinal	JJ
cord-022594-fx044gcd	1096	18	MS	MS	NNP
cord-022594-fx044gcd	1096	19	,	,	,
cord-022594-fx044gcd	1096	20	"	"	''
cord-022594-fx044gcd	1096	21	whereas	whereas	IN
cord-022594-fx044gcd	1096	22	HLA	HLA	NNP
cord-022594-fx044gcd	1096	23	-	-	HYPH
cord-022594-fx044gcd	1096	24	DPB1	DPB1	NNP
cord-022594-fx044gcd	1096	25	*	*	NFP
cord-022594-fx044gcd	1096	26	0301	0301	CD
cord-022594-fx044gcd	1096	27	is	be	VBZ
cord-022594-fx044gcd	1096	28	the	the	DT
cord-022594-fx044gcd	1096	29	most	most	RBS
cord-022594-fx044gcd	1096	30	strongly	strongly	RB
cord-022594-fx044gcd	1096	31	associated	associate	VBN
cord-022594-fx044gcd	1096	32	allele	allele	NN
cord-022594-fx044gcd	1096	33	with	with	IN
cord-022594-fx044gcd	1096	34	conventional	conventional	JJ
cord-022594-fx044gcd	1096	35	MS	MS	NNP
cord-022594-fx044gcd	1096	36	in	in	IN
cord-022594-fx044gcd	1096	37	the	the	DT
cord-022594-fx044gcd	1096	38	Japanese	Japanese	NNPS
cord-022594-fx044gcd	1096	39	.	.	.
cord-022594-fx044gcd	1097	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	1097	2	of	of	IN
cord-022594-fx044gcd	1097	3	ON	ON	NNP
cord-022594-fx044gcd	1097	4	and	and	CC
cord-022594-fx044gcd	1097	5	myelitis	myelitis	NNP
cord-022594-fx044gcd	1097	6	develop	develop	VBP
cord-022594-fx044gcd	1097	7	over	over	IN
cord-022594-fx044gcd	1097	8	hours	hour	NNS
cord-022594-fx044gcd	1097	9	to	to	IN
cord-022594-fx044gcd	1097	10	days	day	NNS
cord-022594-fx044gcd	1097	11	and	and	CC
cord-022594-fx044gcd	1097	12	are	be	VBP
cord-022594-fx044gcd	1097	13	often	often	RB
cord-022594-fx044gcd	1097	14	preceded	precede	VBN
cord-022594-fx044gcd	1097	15	or	or	CC
cord-022594-fx044gcd	1097	16	accompanied	accompany	VBN
cord-022594-fx044gcd	1097	17	by	by	IN
cord-022594-fx044gcd	1097	18	headache	headache	NN
cord-022594-fx044gcd	1097	19	,	,	,
cord-022594-fx044gcd	1097	20	nausea	nausea	NN
cord-022594-fx044gcd	1097	21	,	,	,
cord-022594-fx044gcd	1097	22	somnolence	somnolence	NN
cord-022594-fx044gcd	1097	23	,	,	,
cord-022594-fx044gcd	1097	24	fever	fever	NN
cord-022594-fx044gcd	1097	25	,	,	,
cord-022594-fx044gcd	1097	26	or	or	CC
cord-022594-fx044gcd	1097	27	myalgias	myalgias	NNP
cord-022594-fx044gcd	1097	28	.	.	.
cord-022594-fx044gcd	1098	1	Continued	continued	JJ
cord-022594-fx044gcd	1098	2	progression	progression	NN
cord-022594-fx044gcd	1098	3	of	of	IN
cord-022594-fx044gcd	1098	4	symptoms	symptom	NNS
cord-022594-fx044gcd	1098	5	over	over	IN
cord-022594-fx044gcd	1098	6	weeks	week	NNS
cord-022594-fx044gcd	1098	7	or	or	CC
cord-022594-fx044gcd	1098	8	months	month	NNS
cord-022594-fx044gcd	1098	9	occasionally	occasionally	RB
cord-022594-fx044gcd	1098	10	occurs	occur	VBZ
cord-022594-fx044gcd	1098	11	.	.	.
cord-022594-fx044gcd	1099	1	Most	Most	JJS
cord-022594-fx044gcd	1099	2	patients	patient	NNS
cord-022594-fx044gcd	1099	3	(	(	-LRB-
cord-022594-fx044gcd	1099	4	greater	great	JJR
cord-022594-fx044gcd	1099	5	than	than	IN
cord-022594-fx044gcd	1099	6	80	80	CD
cord-022594-fx044gcd	1099	7	%	%	NN
cord-022594-fx044gcd	1099	8	)	)	-RRB-
cord-022594-fx044gcd	1099	9	develop	develop	VB
cord-022594-fx044gcd	1099	10	bilateral	bilateral	JJ
cord-022594-fx044gcd	1099	11	optic	optic	JJ
cord-022594-fx044gcd	1099	12	neuritis	neuritis	NN
cord-022594-fx044gcd	1099	13	.	.	.
cord-022594-fx044gcd	1100	1	Bitemporal	Bitemporal	NNP
cord-022594-fx044gcd	1100	2	or	or	CC
cord-022594-fx044gcd	1100	3	junctional	junctional	JJ
cord-022594-fx044gcd	1100	4	field	field	NN
cord-022594-fx044gcd	1100	5	deficits	deficit	NNS
cord-022594-fx044gcd	1100	6	,	,	,
cord-022594-fx044gcd	1100	7	indicating	indicate	VBG
cord-022594-fx044gcd	1100	8	chiasm	chiasm	NN
cord-022594-fx044gcd	1100	9	involvement	involvement	NN
cord-022594-fx044gcd	1100	10	,	,	,
cord-022594-fx044gcd	1100	11	are	be	VBP
cord-022594-fx044gcd	1100	12	sometimes	sometimes	RB
cord-022594-fx044gcd	1100	13	present	present	JJ
cord-022594-fx044gcd	1100	14	early	early	RB
cord-022594-fx044gcd	1100	15	in	in	IN
cord-022594-fx044gcd	1100	16	the	the	DT
cord-022594-fx044gcd	1100	17	course	course	NN
cord-022594-fx044gcd	1100	18	of	of	IN
cord-022594-fx044gcd	1100	19	the	the	DT
cord-022594-fx044gcd	1100	20	ON	on	NN
cord-022594-fx044gcd	1100	21	.	.	.
cord-022594-fx044gcd	1101	1	Visual	visual	JJ
cord-022594-fx044gcd	1101	2	loss	loss	NN
cord-022594-fx044gcd	1101	3	is	be	VBZ
cord-022594-fx044gcd	1101	4	often	often	RB
cord-022594-fx044gcd	1101	5	accompanied	accompany	VBN
cord-022594-fx044gcd	1101	6	by	by	IN
cord-022594-fx044gcd	1101	7	periocular	periocular	NNP
cord-022594-fx044gcd	1101	8	pain	pain	NN
cord-022594-fx044gcd	1101	9	,	,	,
cord-022594-fx044gcd	1101	10	and	and	CC
cord-022594-fx044gcd	1101	11	myelitis	myelitis	NNP
cord-022594-fx044gcd	1101	12	onset	onset	NN
cord-022594-fx044gcd	1101	13	is	be	VBZ
cord-022594-fx044gcd	1101	14	sometimes	sometimes	RB
cord-022594-fx044gcd	1101	15	heralded	herald	VBN
cord-022594-fx044gcd	1101	16	by	by	IN
cord-022594-fx044gcd	1101	17	localized	localize	VBN
cord-022594-fx044gcd	1101	18	back	back	RP
cord-022594-fx044gcd	1101	19	or	or	CC
cord-022594-fx044gcd	1101	20	radicular	radicular	JJ
cord-022594-fx044gcd	1101	21	pain	pain	NN
cord-022594-fx044gcd	1101	22	.	.	.
cord-022594-fx044gcd	1102	1	Lhermitte	Lhermitte	NNP
cord-022594-fx044gcd	1102	2	's	's	POS
cord-022594-fx044gcd	1102	3	sign	sign	NN
cord-022594-fx044gcd	1102	4	is	be	VBZ
cord-022594-fx044gcd	1102	5	common	common	JJ
cord-022594-fx044gcd	1102	6	.	.	.
cord-022594-fx044gcd	1103	1	Severe	severe	JJ
cord-022594-fx044gcd	1103	2	degrees	degree	NNS
cord-022594-fx044gcd	1103	3	of	of	IN
cord-022594-fx044gcd	1103	4	neurological	neurological	JJ
cord-022594-fx044gcd	1103	5	deficits	deficit	NNS
cord-022594-fx044gcd	1103	6	are	be	VBP
cord-022594-fx044gcd	1103	7	usual	usual	JJ
cord-022594-fx044gcd	1103	8	,	,	,
cord-022594-fx044gcd	1103	9	and	and	CC
cord-022594-fx044gcd	1103	10	the	the	DT
cord-022594-fx044gcd	1103	11	degree	degree	NN
cord-022594-fx044gcd	1103	12	of	of	IN
cord-022594-fx044gcd	1103	13	recovery	recovery	NN
cord-022594-fx044gcd	1103	14	is	be	VBZ
cord-022594-fx044gcd	1103	15	variable	variable	JJ
cord-022594-fx044gcd	1103	16	.	.	.
cord-022594-fx044gcd	1104	1	Approximately	approximately	RB
cord-022594-fx044gcd	1104	2	35	35	CD
cord-022594-fx044gcd	1104	3	%	%	NN
cord-022594-fx044gcd	1104	4	of	of	IN
cord-022594-fx044gcd	1104	5	NMO	NMO	NNP
cord-022594-fx044gcd	1104	6	patients	patient	NNS
cord-022594-fx044gcd	1104	7	have	have	VBP
cord-022594-fx044gcd	1104	8	a	a	DT
cord-022594-fx044gcd	1104	9	monophasic	monophasic	JJ
cord-022594-fx044gcd	1104	10	illness	illness	NN
cord-022594-fx044gcd	1104	11	,	,	,
cord-022594-fx044gcd	1104	12	55	55	CD
cord-022594-fx044gcd	1104	13	%	%	NN
cord-022594-fx044gcd	1104	14	develop	develop	VBP
cord-022594-fx044gcd	1104	15	relapses	relapse	NNS
cord-022594-fx044gcd	1104	16	usually	usually	RB
cord-022594-fx044gcd	1104	17	limited	limit	VBN
cord-022594-fx044gcd	1104	18	to	to	IN
cord-022594-fx044gcd	1104	19	the	the	DT
cord-022594-fx044gcd	1104	20	optic	optic	JJ
cord-022594-fx044gcd	1104	21	nerves	nerve	NNS
cord-022594-fx044gcd	1104	22	and	and	CC
cord-022594-fx044gcd	1104	23	spinal	spinal	JJ
cord-022594-fx044gcd	1104	24	cord	cord	NN
cord-022594-fx044gcd	1104	25	(	(	-LRB-
cord-022594-fx044gcd	1104	26	relapsing	relapse	VBG
cord-022594-fx044gcd	1104	27	NMO	NMO	NNP
cord-022594-fx044gcd	1104	28	or	or	CC
cord-022594-fx044gcd	1104	29	opticospinal	opticospinal	JJ
cord-022594-fx044gcd	1104	30	MS	MS	NNP
cord-022594-fx044gcd	1104	31	)	)	-RRB-
cord-022594-fx044gcd	1104	32	,	,	,
cord-022594-fx044gcd	1104	33	and	and	CC
cord-022594-fx044gcd	1104	34	rarely	rarely	RB
cord-022594-fx044gcd	1104	35	patients	patient	NNS
cord-022594-fx044gcd	1104	36	have	have	VBP
cord-022594-fx044gcd	1104	37	a	a	DT
cord-022594-fx044gcd	1104	38	fulminantly	fulminantly	RB
cord-022594-fx044gcd	1104	39	progressive	progressive	JJ
cord-022594-fx044gcd	1104	40	course	course	NN
cord-022594-fx044gcd	1104	41	without	without	IN
cord-022594-fx044gcd	1104	42	relapses	relapse	NNS
cord-022594-fx044gcd	1104	43	or	or	CC
cord-022594-fx044gcd	1104	44	a	a	DT
cord-022594-fx044gcd	1104	45	course	course	NN
cord-022594-fx044gcd	1104	46	typical	typical	JJ
cord-022594-fx044gcd	1104	47	of	of	IN
cord-022594-fx044gcd	1104	48	MS	MS	NNP
cord-022594-fx044gcd	1104	49	.	.	.
cord-022594-fx044gcd	1105	1	115	115	CD
cord-022594-fx044gcd	1106	1	According	accord	VBG
cord-022594-fx044gcd	1106	2	to	to	IN
cord-022594-fx044gcd	1106	3	a	a	DT
cord-022594-fx044gcd	1106	4	study	study	NN
cord-022594-fx044gcd	1106	5	conducted	conduct	VBN
cord-022594-fx044gcd	1106	6	at	at	IN
cord-022594-fx044gcd	1106	7	the	the	DT
cord-022594-fx044gcd	1106	8	Mayo	Mayo	NNP
cord-022594-fx044gcd	1106	9	Clinic	Clinic	NNP
cord-022594-fx044gcd	1106	10	,	,	,
cord-022594-fx044gcd	1106	11	115	115	CD
cord-022594-fx044gcd	1106	12	patients	patient	NNS
cord-022594-fx044gcd	1106	13	with	with	IN
cord-022594-fx044gcd	1106	14	a	a	DT
cord-022594-fx044gcd	1106	15	monophasic	monophasic	JJ
cord-022594-fx044gcd	1106	16	course	course	NN
cord-022594-fx044gcd	1106	17	usually	usually	RB
cord-022594-fx044gcd	1106	18	presented	present	VBN
cord-022594-fx044gcd	1106	19	with	with	IN
cord-022594-fx044gcd	1106	20	rapidly	rapidly	RB
cord-022594-fx044gcd	1106	21	sequential	sequential	JJ
cord-022594-fx044gcd	1106	22	events	event	NNS
cord-022594-fx044gcd	1106	23	(	(	-LRB-
cord-022594-fx044gcd	1106	24	median	median	NN
cord-022594-fx044gcd	1106	25	,	,	,
cord-022594-fx044gcd	1106	26	5	5	CD
cord-022594-fx044gcd	1106	27	days	day	NNS
cord-022594-fx044gcd	1106	28	)	)	-RRB-
cord-022594-fx044gcd	1106	29	with	with	IN
cord-022594-fx044gcd	1106	30	only	only	JJ
cord-022594-fx044gcd	1106	31	moderate	moderate	JJ
cord-022594-fx044gcd	1106	32	recovery	recovery	NN
cord-022594-fx044gcd	1106	33	.	.	.
cord-022594-fx044gcd	1107	1	Patients	patient	NNS
cord-022594-fx044gcd	1107	2	showing	show	VBG
cord-022594-fx044gcd	1107	3	characteristics	characteristic	NNS
cord-022594-fx044gcd	1107	4	of	of	IN
cord-022594-fx044gcd	1107	5	the	the	DT
cord-022594-fx044gcd	1107	6	relapsing	relapse	VBG
cord-022594-fx044gcd	1107	7	form	form	NN
cord-022594-fx044gcd	1107	8	of	of	IN
cord-022594-fx044gcd	1107	9	Devic	Devic	NNP
cord-022594-fx044gcd	1107	10	's	's	POS
cord-022594-fx044gcd	1107	11	had	have	VBD
cord-022594-fx044gcd	1107	12	a	a	DT
cord-022594-fx044gcd	1107	13	median	median	JJ
cord-022594-fx044gcd	1107	14	interval	interval	NN
cord-022594-fx044gcd	1107	15	of	of	IN
cord-022594-fx044gcd	1107	16	166	166	CD
cord-022594-fx044gcd	1107	17	days	day	NNS
cord-022594-fx044gcd	1107	18	between	between	IN
cord-022594-fx044gcd	1107	19	index	index	NN
cord-022594-fx044gcd	1107	20	events	event	NNS
cord-022594-fx044gcd	1107	21	,	,	,
cord-022594-fx044gcd	1107	22	followed	follow	VBD
cord-022594-fx044gcd	1107	23	within	within	IN
cord-022594-fx044gcd	1107	24	3	3	CD
cord-022594-fx044gcd	1107	25	years	year	NNS
cord-022594-fx044gcd	1107	26	by	by	IN
cord-022594-fx044gcd	1107	27	clusters	cluster	NNS
cord-022594-fx044gcd	1107	28	of	of	IN
cord-022594-fx044gcd	1107	29	severe	severe	JJ
cord-022594-fx044gcd	1107	30	relapses	relapse	NNS
cord-022594-fx044gcd	1107	31	isolated	isolate	VBN
cord-022594-fx044gcd	1107	32	to	to	IN
cord-022594-fx044gcd	1107	33	the	the	DT
cord-022594-fx044gcd	1107	34	optic	optic	JJ
cord-022594-fx044gcd	1107	35	nerves	nerve	NNS
cord-022594-fx044gcd	1107	36	and	and	CC
cord-022594-fx044gcd	1107	37	spinal	spinal	JJ
cord-022594-fx044gcd	1107	38	cord	cord	NN
cord-022594-fx044gcd	1107	39	.	.	.
cord-022594-fx044gcd	1108	1	Most	Most	JJS
cord-022594-fx044gcd	1108	2	relapsing	relapse	VBG
cord-022594-fx044gcd	1108	3	patients	patient	NNS
cord-022594-fx044gcd	1108	4	developed	develop	VBD
cord-022594-fx044gcd	1108	5	severe	severe	JJ
cord-022594-fx044gcd	1108	6	disability	disability	NN
cord-022594-fx044gcd	1108	7	in	in	IN
cord-022594-fx044gcd	1108	8	a	a	DT
cord-022594-fx044gcd	1108	9	stepwise	stepwise	JJ
cord-022594-fx044gcd	1108	10	manner	manner	NN
cord-022594-fx044gcd	1108	11	.	.	.
cord-022594-fx044gcd	1109	1	Approximately	approximately	RB
cord-022594-fx044gcd	1109	2	one	one	CD
cord-022594-fx044gcd	1109	3	third	third	NN
cord-022594-fx044gcd	1109	4	died	die	VBD
cord-022594-fx044gcd	1109	5	from	from	IN
cord-022594-fx044gcd	1109	6	respiratory	respiratory	JJ
cord-022594-fx044gcd	1109	7	failure	failure	NN
cord-022594-fx044gcd	1109	8	.	.	.
cord-022594-fx044gcd	1110	1	Predictors	predictor	NNS
cord-022594-fx044gcd	1110	2	of	of	IN
cord-022594-fx044gcd	1110	3	a	a	DT
cord-022594-fx044gcd	1110	4	relapsing	relapse	VBG
cord-022594-fx044gcd	1110	5	course	course	NN
cord-022594-fx044gcd	1110	6	in	in	IN
cord-022594-fx044gcd	1110	7	NMO	NMO	NNP
cord-022594-fx044gcd	1110	8	118	118	CD
cord-022594-fx044gcd	1110	9	include	include	VBP
cord-022594-fx044gcd	1110	10	longer	long	RBR
cord-022594-fx044gcd	1110	11	inter	inter	JJ
cord-022594-fx044gcd	1110	12	-	-	JJ
cord-022594-fx044gcd	1110	13	attack	attack	JJ
cord-022594-fx044gcd	1110	14	intervals	interval	NNS
cord-022594-fx044gcd	1110	15	(	(	-LRB-
cord-022594-fx044gcd	1110	16	relative	relative	JJ
cord-022594-fx044gcd	1110	17	risk	risk	NN
cord-022594-fx044gcd	1110	18	[	[	-LRB-
cord-022594-fx044gcd	1110	19	RR	rr	NN
cord-022594-fx044gcd	1110	20	]	]	-RRB-
cord-022594-fx044gcd	1110	21	:	:	:
cord-022594-fx044gcd	1110	22	2.16	2.16	CD
cord-022594-fx044gcd	1110	23	per	per	IN
cord-022594-fx044gcd	1110	24	month	month	NN
cord-022594-fx044gcd	1110	25	increase	increase	NN
cord-022594-fx044gcd	1110	26	)	)	-RRB-
cord-022594-fx044gcd	1110	27	,	,	,
cord-022594-fx044gcd	1110	28	older	old	JJR
cord-022594-fx044gcd	1110	29	age	age	NN
cord-022594-fx044gcd	1110	30	at	at	IN
cord-022594-fx044gcd	1110	31	onset	onset	NN
cord-022594-fx044gcd	1110	32	(	(	-LRB-
cord-022594-fx044gcd	1110	33	RR	RR	NNP
cord-022594-fx044gcd	1110	34	¼	¼	NNP
cord-022594-fx044gcd	1110	35	1.08	1.08	CD
cord-022594-fx044gcd	1110	36	per	per	IN
cord-022594-fx044gcd	1110	37	year	year	NN
cord-022594-fx044gcd	1110	38	increase	increase	NN
cord-022594-fx044gcd	1110	39	)	)	-RRB-
cord-022594-fx044gcd	1110	40	,	,	,
cord-022594-fx044gcd	1110	41	female	female	JJ
cord-022594-fx044gcd	1110	42	sex	sex	NN
cord-022594-fx044gcd	1110	43	(	(	-LRB-
cord-022594-fx044gcd	1110	44	RR	RR	NNP
cord-022594-fx044gcd	1110	45	¼	¼	NNP
cord-022594-fx044gcd	1110	46	10.0	10.0	CD
cord-022594-fx044gcd	1110	47	)	)	-RRB-
cord-022594-fx044gcd	1110	48	,	,	,
cord-022594-fx044gcd	1110	49	and	and	CC
cord-022594-fx044gcd	1110	50	less	less	RBR
cord-022594-fx044gcd	1110	51	severe	severe	JJ
cord-022594-fx044gcd	1110	52	motor	motor	NN
cord-022594-fx044gcd	1110	53	impairment	impairment	NN
cord-022594-fx044gcd	1110	54	with	with	IN
cord-022594-fx044gcd	1110	55	sentinel	sentinel	JJ
cord-022594-fx044gcd	1110	56	myelitis	myelitis	NNP
cord-022594-fx044gcd	1110	57	event	event	NN
cord-022594-fx044gcd	1110	58	(	(	-LRB-
cord-022594-fx044gcd	1110	59	RR	RR	NNP
cord-022594-fx044gcd	1110	60	¼	¼	CD
cord-022594-fx044gcd	1110	61	0.48	0.48	CD
cord-022594-fx044gcd	1110	62	per	per	IN
cord-022594-fx044gcd	1110	63	severity	severity	NN
cord-022594-fx044gcd	1110	64	scale	scale	NN
cord-022594-fx044gcd	1110	65	point	point	NN
cord-022594-fx044gcd	1110	66	increase	increase	NN
cord-022594-fx044gcd	1110	67	)	)	-RRB-
cord-022594-fx044gcd	1110	68	.	.	.
cord-022594-fx044gcd	1111	1	Autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1111	2	disease	disease	NN
cord-022594-fx044gcd	1111	3	history	history	NN
cord-022594-fx044gcd	1111	4	(	(	-LRB-
cord-022594-fx044gcd	1111	5	RR	RR	NNP
cord-022594-fx044gcd	1111	6	¼	¼	NNP
cord-022594-fx044gcd	1111	7	4.15	4.15	CD
cord-022594-fx044gcd	1111	8	)	)	-RRB-
cord-022594-fx044gcd	1111	9	,	,	,
cord-022594-fx044gcd	1111	10	higher	high	JJR
cord-022594-fx044gcd	1111	11	attack	attack	NN
cord-022594-fx044gcd	1111	12	frequency	frequency	NN
cord-022594-fx044gcd	1111	13	in	in	IN
cord-022594-fx044gcd	1111	14	first	first	JJ
cord-022594-fx044gcd	1111	15	2	2	CD
cord-022594-fx044gcd	1111	16	years	year	NNS
cord-022594-fx044gcd	1112	1	(	(	-LRB-
cord-022594-fx044gcd	1112	2	RR	RR	NNP
cord-022594-fx044gcd	1112	3	¼	¼	NNP
cord-022594-fx044gcd	1112	4	1.21	1.21	CD
cord-022594-fx044gcd	1112	5	per	per	IN
cord-022594-fx044gcd	1112	6	attack	attack	NN
cord-022594-fx044gcd	1112	7	)	)	-RRB-
cord-022594-fx044gcd	1112	8	,	,	,
cord-022594-fx044gcd	1112	9	and	and	CC
cord-022594-fx044gcd	1112	10	better	well	JJR
cord-022594-fx044gcd	1112	11	recovery	recovery	NN
cord-022594-fx044gcd	1112	12	following	follow	VBG
cord-022594-fx044gcd	1112	13	index	index	NN
cord-022594-fx044gcd	1112	14	myelitis	myelitis	NNP
cord-022594-fx044gcd	1112	15	(	(	-LRB-
cord-022594-fx044gcd	1112	16	RR	RR	NNP
cord-022594-fx044gcd	1112	17	¼	¼	CD
cord-022594-fx044gcd	1112	18	1.84	1.84	CD
cord-022594-fx044gcd	1112	19	per	per	IN
cord-022594-fx044gcd	1112	20	point	point	NN
cord-022594-fx044gcd	1112	21	)	)	-RRB-
cord-022594-fx044gcd	1112	22	are	be	VBP
cord-022594-fx044gcd	1112	23	associated	associate	VBN
cord-022594-fx044gcd	1112	24	with	with	IN
cord-022594-fx044gcd	1112	25	increased	increase	VBN
cord-022594-fx044gcd	1112	26	mortality	mortality	NN
cord-022594-fx044gcd	1112	27	rate	rate	NN
cord-022594-fx044gcd	1112	28	.	.	.
cord-022594-fx044gcd	1113	1	Features	feature	NNS
cord-022594-fx044gcd	1113	2	of	of	IN
cord-022594-fx044gcd	1113	3	NMO	NMO	NNP
cord-022594-fx044gcd	1113	4	distinct	distinct	JJ
cord-022594-fx044gcd	1113	5	from	from	IN
cord-022594-fx044gcd	1113	6	"	"	``
cord-022594-fx044gcd	1113	7	typical	typical	JJ
cord-022594-fx044gcd	1113	8	"	"	''
cord-022594-fx044gcd	1113	9	MS	MS	NNP
cord-022594-fx044gcd	1113	10	included	include	VBD
cord-022594-fx044gcd	1113	11	normal	normal	JJ
cord-022594-fx044gcd	1113	12	initial	initial	JJ
cord-022594-fx044gcd	1113	13	brain	brain	NN
cord-022594-fx044gcd	1113	14	MRI	MRI	NNP
cord-022594-fx044gcd	1113	15	,	,	,
cord-022594-fx044gcd	1113	16	more	more	JJR
cord-022594-fx044gcd	1113	17	than	than	IN
cord-022594-fx044gcd	1113	18	50	50	CD
cord-022594-fx044gcd	1113	19	cells	cell	NNS
cord-022594-fx044gcd	1113	20	/	/	SYM
cord-022594-fx044gcd	1113	21	mL	ml	NN
cord-022594-fx044gcd	1113	22	in	in	IN
cord-022594-fx044gcd	1113	23	CSF	CSF	NNP
cord-022594-fx044gcd	1113	24	with	with	IN
cord-022594-fx044gcd	1113	25	polymorphonuclear	polymorphonuclear	JJ
cord-022594-fx044gcd	1113	26	predominance	predominance	NN
cord-022594-fx044gcd	1113	27	,	,	,
cord-022594-fx044gcd	1113	28	and	and	CC
cord-022594-fx044gcd	1113	29	lesions	lesion	NNS
cord-022594-fx044gcd	1113	30	extending	extend	VBG
cord-022594-fx044gcd	1113	31	over	over	IN
cord-022594-fx044gcd	1113	32	three	three	CD
cord-022594-fx044gcd	1113	33	or	or	CC
cord-022594-fx044gcd	1113	34	more	more	JJR
cord-022594-fx044gcd	1113	35	vertebral	vertebral	JJ
cord-022594-fx044gcd	1113	36	segments	segment	NNS
cord-022594-fx044gcd	1113	37	on	on	IN
cord-022594-fx044gcd	1113	38	spinal	spinal	JJ
cord-022594-fx044gcd	1113	39	cord	cord	NN
cord-022594-fx044gcd	1113	40	MRI	MRI	NNP
cord-022594-fx044gcd	1113	41	.	.	.
cord-022594-fx044gcd	1114	1	Relapsing	relapse	VBG
cord-022594-fx044gcd	1114	2	NMO	NMO	NNP
cord-022594-fx044gcd	1114	3	is	be	VBZ
cord-022594-fx044gcd	1114	4	often	often	RB
cord-022594-fx044gcd	1114	5	associated	associate	VBN
cord-022594-fx044gcd	1114	6	with	with	IN
cord-022594-fx044gcd	1114	7	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1114	8	disorders	disorder	NNS
cord-022594-fx044gcd	1114	9	,	,	,
cord-022594-fx044gcd	1114	10	most	most	RBS
cord-022594-fx044gcd	1114	11	commonly	commonly	RB
cord-022594-fx044gcd	1114	12	systemic	systemic	JJ
cord-022594-fx044gcd	1114	13	lupus	lupus	NN
cord-022594-fx044gcd	1114	14	erythematosus	erythematosus	NN
cord-022594-fx044gcd	1114	15	.	.	.
cord-022594-fx044gcd	1115	1	These	these	DT
cord-022594-fx044gcd	1115	2	patients	patient	NNS
cord-022594-fx044gcd	1115	3	also	also	RB
cord-022594-fx044gcd	1115	4	frequently	frequently	RB
cord-022594-fx044gcd	1115	5	have	have	VBP
cord-022594-fx044gcd	1115	6	an	an	DT
cord-022594-fx044gcd	1115	7	elevated	elevated	JJ
cord-022594-fx044gcd	1115	8	erythrocyte	erythrocyte	NN
cord-022594-fx044gcd	1115	9	sedimentation	sedimentation	NN
cord-022594-fx044gcd	1115	10	rate	rate	NN
cord-022594-fx044gcd	1115	11	and	and	CC
cord-022594-fx044gcd	1115	12	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	1115	13	elevation	elevation	NN
cord-022594-fx044gcd	1115	14	of	of	IN
cord-022594-fx044gcd	1115	15	autoantibodies	autoantibody	NNS
cord-022594-fx044gcd	1115	16	,	,	,
cord-022594-fx044gcd	1115	17	including	include	VBG
cord-022594-fx044gcd	1115	18	antinuclear	antinuclear	JJ
cord-022594-fx044gcd	1115	19	antibodies	antibody	NNS
cord-022594-fx044gcd	1115	20	,	,	,
cord-022594-fx044gcd	1115	21	anti	anti	JJ
cord-022594-fx044gcd	1115	22	-	-	JJ
cord-022594-fx044gcd	1115	23	ds	ds	JJ
cord-022594-fx044gcd	1115	24	-	-	HYPH
cord-022594-fx044gcd	1115	25	DNA	DNA	NNP
cord-022594-fx044gcd	1115	26	,	,	,
cord-022594-fx044gcd	1115	27	and	and	CC
cord-022594-fx044gcd	1115	28	antiphospholipid	antiphospholipid	NNP
cord-022594-fx044gcd	1115	29	antibodies	antibody	NNS
cord-022594-fx044gcd	1115	30	.	.	.
cord-022594-fx044gcd	1116	1	Tonic	tonic	NN
cord-022594-fx044gcd	1116	2	spasms	spasm	NNS
cord-022594-fx044gcd	1116	3	and	and	CC
cord-022594-fx044gcd	1116	4	neuropathic	neuropathic	JJ
cord-022594-fx044gcd	1116	5	lower	low	JJR
cord-022594-fx044gcd	1116	6	extremity	extremity	NN
cord-022594-fx044gcd	1116	7	pain	pain	NN
cord-022594-fx044gcd	1116	8	are	be	VBP
cord-022594-fx044gcd	1116	9	common	common	JJ
cord-022594-fx044gcd	1116	10	sequelae	sequela	NNS
cord-022594-fx044gcd	1116	11	to	to	IN
cord-022594-fx044gcd	1116	12	the	the	DT
cord-022594-fx044gcd	1116	13	spinal	spinal	JJ
cord-022594-fx044gcd	1116	14	cord	cord	NN
cord-022594-fx044gcd	1116	15	damage	damage	NN
cord-022594-fx044gcd	1116	16	.	.	.
cord-022594-fx044gcd	1117	1	Symptoms	symptom	NNS
cord-022594-fx044gcd	1117	2	referable	referable	JJ
cord-022594-fx044gcd	1117	3	to	to	IN
cord-022594-fx044gcd	1117	4	brain	brain	NN
cord-022594-fx044gcd	1117	5	stem	stem	NN
cord-022594-fx044gcd	1117	6	lesions	lesion	NNS
cord-022594-fx044gcd	1117	7	(	(	-LRB-
cord-022594-fx044gcd	1117	8	nystagmus	nystagmus	NN
cord-022594-fx044gcd	1117	9	,	,	,
cord-022594-fx044gcd	1117	10	ophthalmoparesis	ophthalmoparesis	NN
cord-022594-fx044gcd	1117	11	,	,	,
cord-022594-fx044gcd	1117	12	and	and	CC
cord-022594-fx044gcd	1117	13	vertigo	vertigo	NNP
cord-022594-fx044gcd	1117	14	)	)	-RRB-
cord-022594-fx044gcd	1117	15	can	can	MD
cord-022594-fx044gcd	1117	16	occur	occur	VB
cord-022594-fx044gcd	1117	17	in	in	IN
cord-022594-fx044gcd	1117	18	these	these	DT
cord-022594-fx044gcd	1117	19	patients	patient	NNS
cord-022594-fx044gcd	1117	20	as	as	RB
cord-022594-fx044gcd	1117	21	well	well	RB
cord-022594-fx044gcd	1117	22	.	.	.
cord-022594-fx044gcd	1118	1	DIFFERENTIAL	differential	JJ
cord-022594-fx044gcd	1118	2	DIAGNOSIS	diagnosis	NN
cord-022594-fx044gcd	1118	3	.	.	.
cord-022594-fx044gcd	1119	1	The	the	DT
cord-022594-fx044gcd	1119	2	differential	differential	JJ
cord-022594-fx044gcd	1119	3	diagnoses	diagnosis	NNS
cord-022594-fx044gcd	1119	4	for	for	IN
cord-022594-fx044gcd	1119	5	Devic	Devic	NNP
cord-022594-fx044gcd	1119	6	's	's	POS
cord-022594-fx044gcd	1119	7	syndrome	syndrome	NN
cord-022594-fx044gcd	1119	8	includes	include	VBZ
cord-022594-fx044gcd	1119	9	MS	MS	NNP
cord-022594-fx044gcd	1119	10	,	,	,
cord-022594-fx044gcd	1119	11	ADEM	ADEM	NNP
cord-022594-fx044gcd	1119	12	,	,	,
cord-022594-fx044gcd	1119	13	pulmonary	pulmonary	JJ
cord-022594-fx044gcd	1119	14	tuberculosis	tuberculosis	NN
cord-022594-fx044gcd	1119	15	,	,	,
cord-022594-fx044gcd	1119	16	and	and	CC
cord-022594-fx044gcd	1119	17	viral	viral	JJ
cord-022594-fx044gcd	1119	18	infection	infection	NN
cord-022594-fx044gcd	1119	19	(	(	-LRB-
cord-022594-fx044gcd	1119	20	especially	especially	RB
cord-022594-fx044gcd	1119	21	in	in	IN
cord-022594-fx044gcd	1119	22	the	the	DT
cord-022594-fx044gcd	1119	23	immunocompromised	immunocompromised	JJ
cord-022594-fx044gcd	1119	24	patient	patient	NN
cord-022594-fx044gcd	1119	25	)	)	-RRB-
cord-022594-fx044gcd	1119	26	.	.	.
cord-022594-fx044gcd	1120	1	In	in	IN
cord-022594-fx044gcd	1120	2	patients	patient	NNS
cord-022594-fx044gcd	1120	3	with	with	IN
cord-022594-fx044gcd	1120	4	an	an	DT
cord-022594-fx044gcd	1120	5	apparent	apparent	JJ
cord-022594-fx044gcd	1120	6	affected	affected	JJ
cord-022594-fx044gcd	1120	7	family	family	NN
cord-022594-fx044gcd	1120	8	member	member	NN
cord-022594-fx044gcd	1120	9	,	,	,
cord-022594-fx044gcd	1120	10	consideration	consideration	NN
cord-022594-fx044gcd	1120	11	should	should	MD
cord-022594-fx044gcd	1120	12	be	be	VB
cord-022594-fx044gcd	1120	13	given	give	VBN
cord-022594-fx044gcd	1120	14	to	to	IN
cord-022594-fx044gcd	1120	15	mitochondrial	mitochondrial	JJ
cord-022594-fx044gcd	1120	16	disease	disease	NN
cord-022594-fx044gcd	1120	17	.	.	.
cord-022594-fx044gcd	1121	1	Relapsing	relapse	VBG
cord-022594-fx044gcd	1121	2	NMO	NMO	NNP
cord-022594-fx044gcd	1121	3	should	should	MD
cord-022594-fx044gcd	1121	4	raise	raise	VB
cord-022594-fx044gcd	1121	5	the	the	DT
cord-022594-fx044gcd	1121	6	suspicion	suspicion	NN
cord-022594-fx044gcd	1121	7	for	for	IN
cord-022594-fx044gcd	1121	8	associated	associated	JJ
cord-022594-fx044gcd	1121	9	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1121	10	disorders	disorder	NNS
cord-022594-fx044gcd	1121	11	.	.	.
cord-022594-fx044gcd	1122	1	Because	because	IN
cord-022594-fx044gcd	1122	2	Devic	Devic	NNP
cord-022594-fx044gcd	1122	3	's	's	POS
cord-022594-fx044gcd	1122	4	syndrome	syndrome	NN
cord-022594-fx044gcd	1122	5	can	can	MD
cord-022594-fx044gcd	1122	6	occur	occur	VB
cord-022594-fx044gcd	1122	7	in	in	IN
cord-022594-fx044gcd	1122	8	persons	person	NNS
cord-022594-fx044gcd	1122	9	older	old	JJR
cord-022594-fx044gcd	1122	10	than	than	IN
cord-022594-fx044gcd	1122	11	age	age	NN
cord-022594-fx044gcd	1122	12	60	60	CD
cord-022594-fx044gcd	1122	13	,	,	,
cord-022594-fx044gcd	1122	14	when	when	WRB
cord-022594-fx044gcd	1122	15	an	an	DT
cord-022594-fx044gcd	1122	16	unrelated	unrelated	JJ
cord-022594-fx044gcd	1122	17	ischemic	ischemic	JJ
cord-022594-fx044gcd	1122	18	optic	optic	JJ
cord-022594-fx044gcd	1122	19	neuropathy	neuropathy	NN
cord-022594-fx044gcd	1122	20	could	could	MD
cord-022594-fx044gcd	1122	21	occur	occur	VB
cord-022594-fx044gcd	1122	22	,	,	,
cord-022594-fx044gcd	1122	23	and	and	CC
cord-022594-fx044gcd	1122	24	because	because	IN
cord-022594-fx044gcd	1122	25	isolated	isolated	JJ
cord-022594-fx044gcd	1122	26	or	or	CC
cord-022594-fx044gcd	1122	27	recurrent	recurrent	JJ
cord-022594-fx044gcd	1122	28	myelopathy	myelopathy	NN
cord-022594-fx044gcd	1122	29	may	may	MD
cord-022594-fx044gcd	1122	30	precede	precede	VB
cord-022594-fx044gcd	1122	31	the	the	DT
cord-022594-fx044gcd	1122	32	ON	on	JJ
cord-022594-fx044gcd	1122	33	,	,	,
cord-022594-fx044gcd	1122	34	additional	additional	JJ
cord-022594-fx044gcd	1122	35	consideration	consideration	NN
cord-022594-fx044gcd	1122	36	must	must	MD
cord-022594-fx044gcd	1122	37	be	be	VB
cord-022594-fx044gcd	1122	38	given	give	VBN
cord-022594-fx044gcd	1122	39	to	to	IN
cord-022594-fx044gcd	1122	40	spinal	spinal	JJ
cord-022594-fx044gcd	1122	41	cord	cord	NN
cord-022594-fx044gcd	1122	42	compression	compression	NN
cord-022594-fx044gcd	1122	43	,	,	,
cord-022594-fx044gcd	1122	44	spinal	spinal	JJ
cord-022594-fx044gcd	1122	45	cord	cord	NN
cord-022594-fx044gcd	1122	46	tumor	tumor	NN
cord-022594-fx044gcd	1122	47	,	,	,
cord-022594-fx044gcd	1122	48	and	and	CC
cord-022594-fx044gcd	1122	49	spinal	spinal	JJ
cord-022594-fx044gcd	1122	50	arteriovenous	arteriovenous	JJ
cord-022594-fx044gcd	1122	51	malformation	malformation	NN
cord-022594-fx044gcd	1122	52	(	(	-LRB-
cord-022594-fx044gcd	1122	53	AVM	AVM	NNP
cord-022594-fx044gcd	1122	54	)	)	-RRB-
cord-022594-fx044gcd	1122	55	or	or	CC
cord-022594-fx044gcd	1122	56	dural	dural	JJ
cord-022594-fx044gcd	1122	57	fistula	fistula	NN
cord-022594-fx044gcd	1122	58	.	.	.
cord-022594-fx044gcd	1123	1	EVALUATION	EVALUATION	NNP
cord-022594-fx044gcd	1123	2	.	.	.
cord-022594-fx044gcd	1124	1	Imaging	imaging	NN
cord-022594-fx044gcd	1124	2	is	be	VBZ
cord-022594-fx044gcd	1124	3	needed	need	VBN
cord-022594-fx044gcd	1124	4	to	to	TO
cord-022594-fx044gcd	1124	5	exclude	exclude	VB
cord-022594-fx044gcd	1124	6	structural	structural	JJ
cord-022594-fx044gcd	1124	7	lesions	lesion	NNS
cord-022594-fx044gcd	1124	8	and	and	CC
cord-022594-fx044gcd	1124	9	provide	provide	VB
cord-022594-fx044gcd	1124	10	information	information	NN
cord-022594-fx044gcd	1124	11	on	on	IN
cord-022594-fx044gcd	1124	12	the	the	DT
cord-022594-fx044gcd	1124	13	pathological	pathological	JJ
cord-022594-fx044gcd	1124	14	process	process	NN
cord-022594-fx044gcd	1124	15	.	.	.
cord-022594-fx044gcd	1125	1	Optic	optic	JJ
cord-022594-fx044gcd	1125	2	nerve	nerve	NN
cord-022594-fx044gcd	1125	3	or	or	CC
cord-022594-fx044gcd	1125	4	chiasm	chiasm	NN
cord-022594-fx044gcd	1125	5	enlargement	enlargement	NN
cord-022594-fx044gcd	1125	6	,	,	,
cord-022594-fx044gcd	1126	1	T2-weighted	t2-weighte	VBN
cord-022594-fx044gcd	1126	2	signal	signal	NN
cord-022594-fx044gcd	1126	3	changes	change	NNS
cord-022594-fx044gcd	1126	4	,	,	,
cord-022594-fx044gcd	1126	5	and	and	CC
cord-022594-fx044gcd	1126	6	enhancement	enhancement	NN
cord-022594-fx044gcd	1126	7	may	may	MD
cord-022594-fx044gcd	1126	8	be	be	VB
cord-022594-fx044gcd	1126	9	seen	see	VBN
cord-022594-fx044gcd	1126	10	on	on	IN
cord-022594-fx044gcd	1126	11	head	head	NN
cord-022594-fx044gcd	1126	12	MRI	MRI	NNP
cord-022594-fx044gcd	1126	13	during	during	IN
cord-022594-fx044gcd	1126	14	the	the	DT
cord-022594-fx044gcd	1126	15	acute	acute	JJ
cord-022594-fx044gcd	1126	16	phase	phase	NN
cord-022594-fx044gcd	1126	17	.	.	.
cord-022594-fx044gcd	1127	1	Increased	increase	VBN
cord-022594-fx044gcd	1127	2	T2-weighted	t2-weighted	JJ
cord-022594-fx044gcd	1127	3	signal	signal	NN
cord-022594-fx044gcd	1127	4	in	in	IN
cord-022594-fx044gcd	1127	5	the	the	DT
cord-022594-fx044gcd	1127	6	medulla	medulla	NN
cord-022594-fx044gcd	1127	7	is	be	VBZ
cord-022594-fx044gcd	1127	8	not	not	RB
cord-022594-fx044gcd	1127	9	uncommon	uncommon	JJ
cord-022594-fx044gcd	1127	10	and	and	CC
cord-022594-fx044gcd	1127	11	usually	usually	RB
cord-022594-fx044gcd	1127	12	represents	represent	VBZ
cord-022594-fx044gcd	1127	13	extension	extension	NN
cord-022594-fx044gcd	1127	14	of	of	IN
cord-022594-fx044gcd	1127	15	high	high	JJ
cord-022594-fx044gcd	1127	16	cervical	cervical	JJ
cord-022594-fx044gcd	1127	17	lesions	lesion	NNS
cord-022594-fx044gcd	1127	18	.	.	.
cord-022594-fx044gcd	1128	1	Spine	Spine	NNP
cord-022594-fx044gcd	1128	2	MRI	MRI	NNP
cord-022594-fx044gcd	1128	3	characteristically	characteristically	RB
cord-022594-fx044gcd	1128	4	shows	show	VBZ
cord-022594-fx044gcd	1128	5	cord	cord	NN
cord-022594-fx044gcd	1128	6	swelling	swelling	NN
cord-022594-fx044gcd	1128	7	,	,	,
cord-022594-fx044gcd	1128	8	signal	signal	NN
cord-022594-fx044gcd	1128	9	changes	change	NNS
cord-022594-fx044gcd	1128	10	,	,	,
cord-022594-fx044gcd	1128	11	and	and	CC
cord-022594-fx044gcd	1128	12	enhancement	enhancement	NN
cord-022594-fx044gcd	1128	13	extending	extend	VBG
cord-022594-fx044gcd	1128	14	over	over	RP
cord-022594-fx044gcd	1128	15	at	at	RB
cord-022594-fx044gcd	1128	16	least	least	RBS
cord-022594-fx044gcd	1128	17	three	three	CD
cord-022594-fx044gcd	1128	18	levels	level	NNS
cord-022594-fx044gcd	1128	19	(	(	-LRB-
cord-022594-fx044gcd	1128	20	Fig	Fig	NNP
cord-022594-fx044gcd	1128	21	.	.	.
cord-022594-fx044gcd	1128	22	48	48	CD
cord-022594-fx044gcd	1128	23	-	-	SYM
cord-022594-fx044gcd	1128	24	4	4	CD
cord-022594-fx044gcd	1128	25	)	)	-RRB-
cord-022594-fx044gcd	1128	26	.	.	.
cord-022594-fx044gcd	1129	1	This	this	DT
cord-022594-fx044gcd	1129	2	appearance	appearance	NN
cord-022594-fx044gcd	1129	3	may	may	MD
cord-022594-fx044gcd	1129	4	resemble	resemble	VB
cord-022594-fx044gcd	1129	5	a	a	DT
cord-022594-fx044gcd	1129	6	spinal	spinal	JJ
cord-022594-fx044gcd	1129	7	cord	cord	NN
cord-022594-fx044gcd	1129	8	tumor	tumor	NN
cord-022594-fx044gcd	1129	9	,	,	,
cord-022594-fx044gcd	1129	10	prompting	prompt	VBG
cord-022594-fx044gcd	1129	11	consideration	consideration	NN
cord-022594-fx044gcd	1129	12	for	for	IN
cord-022594-fx044gcd	1129	13	biopsy	biopsy	NN
cord-022594-fx044gcd	1129	14	.	.	.
cord-022594-fx044gcd	1130	1	On	on	IN
cord-022594-fx044gcd	1130	2	magnetization	magnetization	NN
cord-022594-fx044gcd	1130	3	transfer	transfer	NN
cord-022594-fx044gcd	1130	4	(	(	-LRB-
cord-022594-fx044gcd	1130	5	MT	MT	NNP
cord-022594-fx044gcd	1130	6	)	)	-RRB-
cord-022594-fx044gcd	1130	7	MRI	MRI	NNP
cord-022594-fx044gcd	1130	8	,	,	,
cord-022594-fx044gcd	1131	1	no	no	DT
cord-022594-fx044gcd	1131	2	significant	significant	JJ
cord-022594-fx044gcd	1131	3	difference	difference	NN
cord-022594-fx044gcd	1131	4	was	be	VBD
cord-022594-fx044gcd	1131	5	found	find	VBN
cord-022594-fx044gcd	1131	6	on	on	IN
cord-022594-fx044gcd	1131	7	normal	normal	RB
cord-022594-fx044gcd	1131	8	-	-	HYPH
cord-022594-fx044gcd	1131	9	appearing	appear	VBG
cord-022594-fx044gcd	1131	10	white	white	JJ
cord-022594-fx044gcd	1131	11	matter	matter	NN
cord-022594-fx044gcd	1131	12	of	of	IN
cord-022594-fx044gcd	1131	13	Devic	Devic	NNP
cord-022594-fx044gcd	1131	14	's	's	POS
cord-022594-fx044gcd	1131	15	patients	patient	NNS
cord-022594-fx044gcd	1131	16	and	and	CC
cord-022594-fx044gcd	1131	17	control	control	NN
cord-022594-fx044gcd	1131	18	subjects	subject	NNS
cord-022594-fx044gcd	1131	19	,	,	,
cord-022594-fx044gcd	1131	20	whereas	whereas	IN
cord-022594-fx044gcd	1131	21	MS	MS	NNP
cord-022594-fx044gcd	1131	22	patients	patient	NNS
cord-022594-fx044gcd	1131	23	had	have	VBD
cord-022594-fx044gcd	1131	24	a	a	DT
cord-022594-fx044gcd	1131	25	significantly	significantly	RB
cord-022594-fx044gcd	1131	26	lower	low	JJR
cord-022594-fx044gcd	1131	27	MT	MT	NNP
cord-022594-fx044gcd	1131	28	ratio	ratio	NN
cord-022594-fx044gcd	1131	29	peak	peak	NN
cord-022594-fx044gcd	1131	30	and	and	CC
cord-022594-fx044gcd	1131	31	histogram	histogram	NN
cord-022594-fx044gcd	1131	32	average	average	NN
cord-022594-fx044gcd	1131	33	.	.	.
cord-022594-fx044gcd	1132	1	119	119	CD
cord-022594-fx044gcd	1132	2	T1	T1	NNP
cord-022594-fx044gcd	1132	3	hypointense	hypointense	NN
cord-022594-fx044gcd	1132	4	lesions	lesion	NNS
cord-022594-fx044gcd	1132	5	in	in	IN
cord-022594-fx044gcd	1132	6	the	the	DT
cord-022594-fx044gcd	1132	7	cord	cord	NN
cord-022594-fx044gcd	1132	8	and	and	CC
cord-022594-fx044gcd	1132	9	linear	linear	JJ
cord-022594-fx044gcd	1132	10	lesions	lesion	NNS
cord-022594-fx044gcd	1132	11	that	that	WDT
cord-022594-fx044gcd	1132	12	cross	cross	VBP
cord-022594-fx044gcd	1132	13	over	over	RP
cord-022594-fx044gcd	1132	14	more	more	JJR
cord-022594-fx044gcd	1132	15	than	than	IN
cord-022594-fx044gcd	1132	16	two	two	CD
cord-022594-fx044gcd	1132	17	segments	segment	NNS
cord-022594-fx044gcd	1132	18	are	be	VBP
cord-022594-fx044gcd	1132	19	more	more	RBR
cord-022594-fx044gcd	1132	20	suggestive	suggestive	JJ
cord-022594-fx044gcd	1132	21	of	of	IN
cord-022594-fx044gcd	1132	22	Devic	Devic	NNP
cord-022594-fx044gcd	1132	23	's	's	POS
cord-022594-fx044gcd	1132	24	disease	disease	NN
cord-022594-fx044gcd	1132	25	.	.	.
cord-022594-fx044gcd	1133	1	An	an	DT
cord-022594-fx044gcd	1133	2	occasional	occasional	JJ
cord-022594-fx044gcd	1133	3	patient	patient	NN
cord-022594-fx044gcd	1133	4	may	may	MD
cord-022594-fx044gcd	1133	5	need	need	VB
cord-022594-fx044gcd	1133	6	prone	prone	JJ
cord-022594-fx044gcd	1133	7	and	and	CC
cord-022594-fx044gcd	1133	8	supine	supine	JJ
cord-022594-fx044gcd	1133	9	myelography	myelography	NN
cord-022594-fx044gcd	1133	10	to	to	TO
cord-022594-fx044gcd	1133	11	exclude	exclude	VB
cord-022594-fx044gcd	1133	12	a	a	DT
cord-022594-fx044gcd	1133	13	spinal	spinal	JJ
cord-022594-fx044gcd	1133	14	dural	dural	NN
cord-022594-fx044gcd	1133	15	-	-	HYPH
cord-022594-fx044gcd	1133	16	based	base	VBN
cord-022594-fx044gcd	1133	17	AVM	AVM	NNP
cord-022594-fx044gcd	1133	18	.	.	.
cord-022594-fx044gcd	1134	1	Laboratory	laboratory	NN
cord-022594-fx044gcd	1134	2	investigations	investigation	NNS
cord-022594-fx044gcd	1134	3	reveal	reveal	VBP
cord-022594-fx044gcd	1134	4	an	an	DT
cord-022594-fx044gcd	1134	5	elevated	elevated	JJ
cord-022594-fx044gcd	1134	6	erythrocyte	erythrocyte	NN
cord-022594-fx044gcd	1134	7	sedimentation	sedimentation	NN
cord-022594-fx044gcd	1134	8	rate	rate	NN
cord-022594-fx044gcd	1134	9	in	in	IN
cord-022594-fx044gcd	1134	10	one	one	CD
cord-022594-fx044gcd	1134	11	third	third	JJ
cord-022594-fx044gcd	1134	12	,	,	,
cord-022594-fx044gcd	1134	13	positive	positive	JJ
cord-022594-fx044gcd	1134	14	antinuclear	antinuclear	JJ
cord-022594-fx044gcd	1134	15	antibodies	antibody	NNS
cord-022594-fx044gcd	1134	16	in	in	IN
cord-022594-fx044gcd	1134	17	nearly	nearly	RB
cord-022594-fx044gcd	1134	18	one	one	CD
cord-022594-fx044gcd	1134	19	half	half	NN
cord-022594-fx044gcd	1134	20	,	,	,
cord-022594-fx044gcd	1134	21	and	and	CC
cord-022594-fx044gcd	1134	22	occasionally	occasionally	RB
cord-022594-fx044gcd	1134	23	other	other	JJ
cord-022594-fx044gcd	1134	24	autoantibodies	autoantibody	NNS
cord-022594-fx044gcd	1134	25	(	(	-LRB-
cord-022594-fx044gcd	1134	26	e.g.	e.g.	RB
cord-022594-fx044gcd	1134	27	,	,	,
cord-022594-fx044gcd	1134	28	thyroperoxidase	thyroperoxidase	NN
cord-022594-fx044gcd	1134	29	antibodies	antibody	NNS
cord-022594-fx044gcd	1134	30	)	)	-RRB-
cord-022594-fx044gcd	1134	31	.	.	.
cord-022594-fx044gcd	1135	1	39	39	CD
cord-022594-fx044gcd	1136	1	It	-PRON-	PRP
cord-022594-fx044gcd	1136	2	is	be	VBZ
cord-022594-fx044gcd	1136	3	reasonable	reasonable	JJ
cord-022594-fx044gcd	1136	4	to	to	TO
cord-022594-fx044gcd	1136	5	exclude	exclude	VB
cord-022594-fx044gcd	1136	6	syphilis	syphili	NNS
cord-022594-fx044gcd	1136	7	,	,	,
cord-022594-fx044gcd	1136	8	Lyme	Lyme	NNP
cord-022594-fx044gcd	1136	9	disease	disease	NN
cord-022594-fx044gcd	1136	10	,	,	,
cord-022594-fx044gcd	1136	11	and	and	CC
cord-022594-fx044gcd	1136	12	human	human	JJ
cord-022594-fx044gcd	1136	13	immunodeficiency	immunodeficiency	NN
cord-022594-fx044gcd	1136	14	virus	virus	NN
cord-022594-fx044gcd	1136	15	by	by	IN
cord-022594-fx044gcd	1136	16	laboratory	laboratory	NN
cord-022594-fx044gcd	1136	17	testing	testing	NN
cord-022594-fx044gcd	1136	18	.	.	.
cord-022594-fx044gcd	1137	1	In	in	IN
cord-022594-fx044gcd	1137	2	a	a	DT
cord-022594-fx044gcd	1137	3	few	few	JJ
cord-022594-fx044gcd	1137	4	patients	patient	NNS
cord-022594-fx044gcd	1137	5	with	with	IN
cord-022594-fx044gcd	1137	6	the	the	DT
cord-022594-fx044gcd	1137	7	Far	Far	NNP
cord-022594-fx044gcd	1137	8	East	East	NNP
cord-022594-fx044gcd	1137	9	variety	variety	NN
cord-022594-fx044gcd	1137	10	of	of	IN
cord-022594-fx044gcd	1137	11	Devic	Devic	NNP
cord-022594-fx044gcd	1137	12	's	's	POS
cord-022594-fx044gcd	1137	13	disease	disease	NN
cord-022594-fx044gcd	1137	14	,	,	,
cord-022594-fx044gcd	1137	15	hyperprolactinemia	hyperprolactinemia	NNP
cord-022594-fx044gcd	1137	16	was	be	VBD
cord-022594-fx044gcd	1137	17	described	describe	VBN
cord-022594-fx044gcd	1137	18	predominantly	predominantly	RB
cord-022594-fx044gcd	1137	19	with	with	IN
cord-022594-fx044gcd	1137	20	optic	optic	JJ
cord-022594-fx044gcd	1137	21	nerve	nerve	NN
cord-022594-fx044gcd	1137	22	involvement	involvement	NN
cord-022594-fx044gcd	1137	23	.	.	.
cord-022594-fx044gcd	1138	1	A	a	DT
cord-022594-fx044gcd	1138	2	chest	chest	NN
cord-022594-fx044gcd	1138	3	x	x	NN
cord-022594-fx044gcd	1138	4	-	-	NN
cord-022594-fx044gcd	1138	5	ray	ray	NN
cord-022594-fx044gcd	1138	6	helps	help	VBZ
cord-022594-fx044gcd	1138	7	to	to	TO
cord-022594-fx044gcd	1138	8	exclude	exclude	VB
cord-022594-fx044gcd	1138	9	pulmonary	pulmonary	JJ
cord-022594-fx044gcd	1138	10	tuberculosis	tuberculosis	NN
cord-022594-fx044gcd	1138	11	and	and	CC
cord-022594-fx044gcd	1138	12	sarcoidosis	sarcoidosis	NN
cord-022594-fx044gcd	1138	13	.	.	.
cord-022594-fx044gcd	1139	1	CSF	csf	NN
cord-022594-fx044gcd	1139	2	examination	examination	NN
cord-022594-fx044gcd	1139	3	is	be	VBZ
cord-022594-fx044gcd	1139	4	an	an	DT
cord-022594-fx044gcd	1139	5	essential	essential	JJ
cord-022594-fx044gcd	1139	6	part	part	NN
cord-022594-fx044gcd	1139	7	of	of	IN
cord-022594-fx044gcd	1139	8	the	the	DT
cord-022594-fx044gcd	1139	9	evaluation	evaluation	NN
cord-022594-fx044gcd	1139	10	for	for	IN
cord-022594-fx044gcd	1139	11	Devic	Devic	NNP
cord-022594-fx044gcd	1139	12	's	's	POS
cord-022594-fx044gcd	1139	13	syndrome	syndrome	NN
cord-022594-fx044gcd	1139	14	,	,	,
cord-022594-fx044gcd	1139	15	and	and	CC
cord-022594-fx044gcd	1139	16	repeated	repeat	VBN
cord-022594-fx044gcd	1139	17	studies	study	NNS
cord-022594-fx044gcd	1139	18	are	be	VBP
cord-022594-fx044gcd	1139	19	sometimes	sometimes	RB
cord-022594-fx044gcd	1139	20	necessary	necessary	JJ
cord-022594-fx044gcd	1139	21	to	to	TO
cord-022594-fx044gcd	1139	22	ensure	ensure	VB
cord-022594-fx044gcd	1139	23	that	that	IN
cord-022594-fx044gcd	1139	24	there	there	EX
cord-022594-fx044gcd	1139	25	is	be	VBZ
cord-022594-fx044gcd	1139	26	no	no	DT
cord-022594-fx044gcd	1139	27	infection	infection	NN
cord-022594-fx044gcd	1139	28	in	in	IN
cord-022594-fx044gcd	1139	29	that	that	IN
cord-022594-fx044gcd	1139	30	the	the	DT
cord-022594-fx044gcd	1139	31	CSF	CSF	NNP
cord-022594-fx044gcd	1139	32	findings	finding	NNS
cord-022594-fx044gcd	1139	33	are	be	VBP
cord-022594-fx044gcd	1139	34	sometimes	sometimes	RB
cord-022594-fx044gcd	1139	35	atypical	atypical	JJ
cord-022594-fx044gcd	1139	36	for	for	IN
cord-022594-fx044gcd	1139	37	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1139	38	demyelination	demyelination	NN
cord-022594-fx044gcd	1139	39	.	.	.
cord-022594-fx044gcd	1140	1	A	a	DT
cord-022594-fx044gcd	1140	2	marked	marked	JJ
cord-022594-fx044gcd	1140	3	pleocytosis	pleocytosis	NN
cord-022594-fx044gcd	1140	4	is	be	VBZ
cord-022594-fx044gcd	1140	5	often	often	RB
cord-022594-fx044gcd	1140	6	present	present	JJ
cord-022594-fx044gcd	1140	7	,	,	,
cord-022594-fx044gcd	1140	8	sometimes	sometimes	RB
cord-022594-fx044gcd	1140	9	exceeding	exceed	VBG
cord-022594-fx044gcd	1140	10	100	100	CD
cord-022594-fx044gcd	1140	11	cells	cell	NNS
cord-022594-fx044gcd	1140	12	.	.	.
cord-022594-fx044gcd	1141	1	Moreover	moreover	RB
cord-022594-fx044gcd	1141	2	,	,	,
cord-022594-fx044gcd	1141	3	neutrophils	neutrophil	NNS
cord-022594-fx044gcd	1141	4	are	be	VBP
cord-022594-fx044gcd	1141	5	commonly	commonly	RB
cord-022594-fx044gcd	1141	6	seen	see	VBN
cord-022594-fx044gcd	1141	7	in	in	IN
cord-022594-fx044gcd	1141	8	CSF	CSF	NNP
cord-022594-fx044gcd	1141	9	and	and	CC
cord-022594-fx044gcd	1141	10	may	may	MD
cord-022594-fx044gcd	1141	11	predominate	predominate	VB
cord-022594-fx044gcd	1141	12	,	,	,
cord-022594-fx044gcd	1141	13	a	a	DT
cord-022594-fx044gcd	1141	14	situation	situation	NN
cord-022594-fx044gcd	1141	15	virtually	virtually	RB
cord-022594-fx044gcd	1141	16	unknown	unknown	JJ
cord-022594-fx044gcd	1141	17	in	in	IN
cord-022594-fx044gcd	1141	18	MS	MS	NNP
cord-022594-fx044gcd	1141	19	.	.	.
cord-022594-fx044gcd	1142	1	120	120	CD
cord-022594-fx044gcd	1143	1	The	the	DT
cord-022594-fx044gcd	1143	2	protein	protein	NN
cord-022594-fx044gcd	1143	3	concentration	concentration	NN
cord-022594-fx044gcd	1143	4	is	be	VBZ
cord-022594-fx044gcd	1143	5	often	often	RB
cord-022594-fx044gcd	1143	6	very	very	RB
cord-022594-fx044gcd	1143	7	high	high	JJ
cord-022594-fx044gcd	1143	8	and	and	CC
cord-022594-fx044gcd	1143	9	in	in	IN
cord-022594-fx044gcd	1143	10	41	41	CD
cord-022594-fx044gcd	1143	11	%	%	NN
cord-022594-fx044gcd	1143	12	exceeds	exceed	VBZ
cord-022594-fx044gcd	1143	13	100	100	CD
cord-022594-fx044gcd	1143	14	mg	mg	NNP
cord-022594-fx044gcd	1143	15	/	/	SYM
cord-022594-fx044gcd	1143	16	dL.	dl.	JJ
cord-022594-fx044gcd	1143	17	Anti	Anti	NNP
cord-022594-fx044gcd	1143	18	-	-	NNP
cord-022594-fx044gcd	1143	19	MOG	MOG	NNP
cord-022594-fx044gcd	1143	20	antibodies	antibody	NNS
cord-022594-fx044gcd	1143	21	are	be	VBP
cord-022594-fx044gcd	1143	22	the	the	DT
cord-022594-fx044gcd	1143	23	predominant	predominant	JJ
cord-022594-fx044gcd	1143	24	autoantibody	autoantibody	NN
cord-022594-fx044gcd	1143	25	detected	detect	VBD
cord-022594-fx044gcd	1143	26	in	in	IN
cord-022594-fx044gcd	1143	27	CSF	CSF	NNP
cord-022594-fx044gcd	1143	28	;	;	:
cord-022594-fx044gcd	1143	29	anti	anti	JJ
cord-022594-fx044gcd	1143	30	-	-	JJ
cord-022594-fx044gcd	1143	31	MBP	mbp	JJ
cord-022594-fx044gcd	1143	32	or	or	CC
cord-022594-fx044gcd	1143	33	anti	anti	JJ
cord-022594-fx044gcd	1143	34	-	-	JJ
cord-022594-fx044gcd	1143	35	S100b	s100b	JJ
cord-022594-fx044gcd	1143	36	antibodies	antibody	NNS
cord-022594-fx044gcd	1143	37	are	be	VBP
cord-022594-fx044gcd	1143	38	less	less	RBR
cord-022594-fx044gcd	1143	39	frequently	frequently	RB
cord-022594-fx044gcd	1143	40	seen	see	VBN
cord-022594-fx044gcd	1143	41	.	.	.
cord-022594-fx044gcd	1144	1	Despite	despite	IN
cord-022594-fx044gcd	1144	2	the	the	DT
cord-022594-fx044gcd	1144	3	intense	intense	JJ
cord-022594-fx044gcd	1144	4	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1144	5	response	response	NN
cord-022594-fx044gcd	1144	6	,	,	,
cord-022594-fx044gcd	1144	7	OCBs	ocb	NNS
cord-022594-fx044gcd	1144	8	are	be	VBP
cord-022594-fx044gcd	1144	9	conspicuously	conspicuously	RB
cord-022594-fx044gcd	1144	10	absent	absent	JJ
cord-022594-fx044gcd	1144	11	in	in	IN
cord-022594-fx044gcd	1144	12	the	the	DT
cord-022594-fx044gcd	1144	13	majority	majority	NN
cord-022594-fx044gcd	1144	14	,	,	,
cord-022594-fx044gcd	1144	15	being	be	VBG
cord-022594-fx044gcd	1144	16	present	present	JJ
cord-022594-fx044gcd	1144	17	in	in	IN
cord-022594-fx044gcd	1144	18	fewer	few	JJR
cord-022594-fx044gcd	1144	19	than	than	IN
cord-022594-fx044gcd	1144	20	20	20	CD
cord-022594-fx044gcd	1144	21	%	%	NN
cord-022594-fx044gcd	1144	22	of	of	IN
cord-022594-fx044gcd	1144	23	patients	patient	NNS
cord-022594-fx044gcd	1144	24	.	.	.
cord-022594-fx044gcd	1145	1	CSF	CSF	NNP
cord-022594-fx044gcd	1145	2	serology	serology	NN
cord-022594-fx044gcd	1145	3	for	for	IN
cord-022594-fx044gcd	1145	4	the	the	DT
cord-022594-fx044gcd	1145	5	herpesvirus	herpesvirus	NN
cord-022594-fx044gcd	1145	6	family	family	NN
cord-022594-fx044gcd	1145	7	(	(	-LRB-
cord-022594-fx044gcd	1145	8	HSV	HSV	NNP
cord-022594-fx044gcd	1145	9	types	type	NNS
cord-022594-fx044gcd	1145	10	1	1	CD
cord-022594-fx044gcd	1145	11	and	and	CC
cord-022594-fx044gcd	1145	12	2	2	CD
cord-022594-fx044gcd	1145	13	,	,	,
cord-022594-fx044gcd	1145	14	VZV	VZV	NNP
cord-022594-fx044gcd	1145	15	,	,	,
cord-022594-fx044gcd	1145	16	EBV	EBV	NNP
cord-022594-fx044gcd	1145	17	,	,	,
cord-022594-fx044gcd	1145	18	and	and	CC
cord-022594-fx044gcd	1145	19	CMV	CMV	NNP
cord-022594-fx044gcd	1145	20	)	)	-RRB-
cord-022594-fx044gcd	1145	21	is	be	VBZ
cord-022594-fx044gcd	1145	22	important	important	JJ
cord-022594-fx044gcd	1145	23	,	,	,
cord-022594-fx044gcd	1145	24	and	and	CC
cord-022594-fx044gcd	1145	25	polymerase	polymerase	NN
cord-022594-fx044gcd	1145	26	chain	chain	NN
cord-022594-fx044gcd	1145	27	reaction	reaction	NN
cord-022594-fx044gcd	1145	28	testing	testing	NN
cord-022594-fx044gcd	1145	29	should	should	MD
cord-022594-fx044gcd	1145	30	be	be	VB
cord-022594-fx044gcd	1145	31	done	do	VBN
cord-022594-fx044gcd	1145	32	in	in	IN
cord-022594-fx044gcd	1145	33	cases	case	NNS
cord-022594-fx044gcd	1145	34	suggestive	suggestive	JJ
cord-022594-fx044gcd	1145	35	of	of	IN
cord-022594-fx044gcd	1145	36	viral	viral	JJ
cord-022594-fx044gcd	1145	37	infection	infection	NN
cord-022594-fx044gcd	1145	38	(	(	-LRB-
cord-022594-fx044gcd	1145	39	immunocompromised	immunocompromised	JJ
cord-022594-fx044gcd	1145	40	patients	patient	NNS
cord-022594-fx044gcd	1145	41	)	)	-RRB-
cord-022594-fx044gcd	1145	42	.	.	.
cord-022594-fx044gcd	1146	1	MANAGEMENT	management	NN
cord-022594-fx044gcd	1146	2	.	.	.
cord-022594-fx044gcd	1147	1	Patients	patient	NNS
cord-022594-fx044gcd	1147	2	with	with	IN
cord-022594-fx044gcd	1147	3	acute	acute	JJ
cord-022594-fx044gcd	1147	4	or	or	CC
cord-022594-fx044gcd	1147	5	subacute	subacute	JJ
cord-022594-fx044gcd	1147	6	Devic	Devic	NNP
cord-022594-fx044gcd	1147	7	's	's	POS
cord-022594-fx044gcd	1147	8	syndrome	syndrome	NN
cord-022594-fx044gcd	1147	9	may	may	MD
cord-022594-fx044gcd	1147	10	respond	respond	VB
cord-022594-fx044gcd	1147	11	to	to	IN
cord-022594-fx044gcd	1147	12	corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	1147	13	(	(	-LRB-
cord-022594-fx044gcd	1147	14	e.g.	e.g.	RB
cord-022594-fx044gcd	1147	15	,	,	,
cord-022594-fx044gcd	1147	16	intravenous	intravenous	JJ
cord-022594-fx044gcd	1147	17	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	1147	18	)	)	-RRB-
cord-022594-fx044gcd	1147	19	.	.	.
cord-022594-fx044gcd	1148	1	They	-PRON-	PRP
cord-022594-fx044gcd	1148	2	may	may	MD
cord-022594-fx044gcd	1148	3	respond	respond	VB
cord-022594-fx044gcd	1148	4	to	to	IN
cord-022594-fx044gcd	1148	5	plasma	plasma	NN
cord-022594-fx044gcd	1148	6	exchange	exchange	NN
cord-022594-fx044gcd	1148	7	even	even	RB
cord-022594-fx044gcd	1148	8	when	when	WRB
cord-022594-fx044gcd	1148	9	intravenous	intravenous	JJ
cord-022594-fx044gcd	1148	10	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	1148	11	does	do	VBZ
cord-022594-fx044gcd	1148	12	not	not	RB
cord-022594-fx044gcd	1148	13	produce	produce	VB
cord-022594-fx044gcd	1148	14	significant	significant	JJ
cord-022594-fx044gcd	1148	15	improvement	improvement	NN
cord-022594-fx044gcd	1148	16	.	.	.
cord-022594-fx044gcd	1149	1	Attempts	attempt	NNS
cord-022594-fx044gcd	1149	2	at	at	IN
cord-022594-fx044gcd	1149	3	preventing	prevent	VBG
cord-022594-fx044gcd	1149	4	relapses	relapse	NNS
cord-022594-fx044gcd	1149	5	and	and	CC
cord-022594-fx044gcd	1149	6	the	the	DT
cord-022594-fx044gcd	1149	7	subsequent	subsequent	JJ
cord-022594-fx044gcd	1149	8	disability	disability	NN
cord-022594-fx044gcd	1149	9	are	be	VBP
cord-022594-fx044gcd	1149	10	often	often	RB
cord-022594-fx044gcd	1149	11	disappointing	disappoint	VBG
cord-022594-fx044gcd	1149	12	even	even	RB
cord-022594-fx044gcd	1149	13	with	with	IN
cord-022594-fx044gcd	1149	14	the	the	DT
cord-022594-fx044gcd	1149	15	use	use	NN
cord-022594-fx044gcd	1149	16	of	of	IN
cord-022594-fx044gcd	1149	17	immunosuppressive	immunosuppressive	JJ
cord-022594-fx044gcd	1149	18	agents	agent	NNS
cord-022594-fx044gcd	1149	19	.	.	.
cord-022594-fx044gcd	1150	1	The	the	DT
cord-022594-fx044gcd	1150	2	classic	classic	JJ
cord-022594-fx044gcd	1150	3	injectable	injectable	JJ
cord-022594-fx044gcd	1150	4	immunomodulators	immunomodulator	NNS
cord-022594-fx044gcd	1150	5	used	use	VBN
cord-022594-fx044gcd	1150	6	in	in	IN
cord-022594-fx044gcd	1150	7	MS	MS	NNP
cord-022594-fx044gcd	1150	8	are	be	VBP
cord-022594-fx044gcd	1150	9	insufficient	insufficient	JJ
cord-022594-fx044gcd	1150	10	to	to	TO
cord-022594-fx044gcd	1150	11	reduce	reduce	VB
cord-022594-fx044gcd	1150	12	the	the	DT
cord-022594-fx044gcd	1150	13	relapse	relapse	NN
cord-022594-fx044gcd	1150	14	rate	rate	NN
cord-022594-fx044gcd	1150	15	in	in	IN
cord-022594-fx044gcd	1150	16	relapsing	relapse	VBG
cord-022594-fx044gcd	1150	17	NMO	NMO	NNP
cord-022594-fx044gcd	1150	18	.	.	.
cord-022594-fx044gcd	1151	1	Most	most	RBS
cord-022594-fx044gcd	1151	2	commonly	commonly	RB
cord-022594-fx044gcd	1151	3	,	,	,
cord-022594-fx044gcd	1151	4	a	a	DT
cord-022594-fx044gcd	1151	5	combination	combination	NN
cord-022594-fx044gcd	1151	6	of	of	IN
cord-022594-fx044gcd	1151	7	azathioprine	azathioprine	NN
cord-022594-fx044gcd	1151	8	and	and	CC
cord-022594-fx044gcd	1151	9	prednisone	prednisone	NN
cord-022594-fx044gcd	1151	10	is	be	VBZ
cord-022594-fx044gcd	1151	11	used	use	VBN
cord-022594-fx044gcd	1151	12	for	for	IN
cord-022594-fx044gcd	1151	13	secondary	secondary	JJ
cord-022594-fx044gcd	1151	14	prevention	prevention	NN
cord-022594-fx044gcd	1151	15	.	.	.
cord-022594-fx044gcd	1152	1	Other	other	JJ
cord-022594-fx044gcd	1152	2	agents	agent	NNS
cord-022594-fx044gcd	1152	3	including	include	VBG
cord-022594-fx044gcd	1152	4	mycophenolate	mycophenolate	NNP
cord-022594-fx044gcd	1152	5	mofetil	mofetil	NNP
cord-022594-fx044gcd	1152	6	,	,	,
cord-022594-fx044gcd	1152	7	IVIG	IVIG	NNP
cord-022594-fx044gcd	1152	8	,	,	,
cord-022594-fx044gcd	1152	9	and	and	CC
cord-022594-fx044gcd	1152	10	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	1152	11	have	have	VBP
cord-022594-fx044gcd	1152	12	been	be	VBN
cord-022594-fx044gcd	1152	13	described	describe	VBN
cord-022594-fx044gcd	1152	14	to	to	TO
cord-022594-fx044gcd	1152	15	be	be	VB
cord-022594-fx044gcd	1152	16	effective	effective	JJ
cord-022594-fx044gcd	1152	17	in	in	IN
cord-022594-fx044gcd	1152	18	some	some	DT
cord-022594-fx044gcd	1152	19	cases	case	NNS
cord-022594-fx044gcd	1152	20	.	.	.
cord-022594-fx044gcd	1153	1	A	a	DT
cord-022594-fx044gcd	1153	2	small	small	JJ
cord-022594-fx044gcd	1153	3	study	study	NN
cord-022594-fx044gcd	1153	4	of	of	IN
cord-022594-fx044gcd	1153	5	rituximab	rituximab	NN
cord-022594-fx044gcd	1153	6	,	,	,
cord-022594-fx044gcd	1153	7	a	a	DT
cord-022594-fx044gcd	1153	8	humanized	humanize	VBN
cord-022594-fx044gcd	1153	9	anti	anti	JJ
cord-022594-fx044gcd	1153	10	-	-	JJ
cord-022594-fx044gcd	1153	11	CD20	CD20	NNP
cord-022594-fx044gcd	1153	12	antibody	antibody	NN
cord-022594-fx044gcd	1153	13	showed	show	VBD
cord-022594-fx044gcd	1153	14	a	a	DT
cord-022594-fx044gcd	1153	15	siginifcant	siginifcant	JJ
cord-022594-fx044gcd	1153	16	reduction	reduction	NN
cord-022594-fx044gcd	1153	17	in	in	IN
cord-022594-fx044gcd	1153	18	the	the	DT
cord-022594-fx044gcd	1153	19	relapse	relapse	NN
cord-022594-fx044gcd	1153	20	rate	rate	NN
cord-022594-fx044gcd	1153	21	of	of	IN
cord-022594-fx044gcd	1153	22	8	8	CD
cord-022594-fx044gcd	1153	23	patients	patient	NNS
cord-022594-fx044gcd	1153	24	,	,	,
cord-022594-fx044gcd	1153	25	making	make	VBG
cord-022594-fx044gcd	1153	26	6	6	CD
cord-022594-fx044gcd	1153	27	of	of	IN
cord-022594-fx044gcd	1153	28	8	8	CD
cord-022594-fx044gcd	1153	29	relapse	relapse	NN
cord-022594-fx044gcd	1153	30	free	free	JJ
cord-022594-fx044gcd	1153	31	.	.	.
cord-022594-fx044gcd	1154	1	121	121	CD
cord-022594-fx044gcd	1155	1	A	a	DT
cord-022594-fx044gcd	1155	2	large	large	JJ
cord-022594-fx044gcd	1155	3	multicenter	multicenter	JJ
cord-022594-fx044gcd	1155	4	study	study	NN
cord-022594-fx044gcd	1155	5	of	of	IN
cord-022594-fx044gcd	1155	6	rituximab	rituximab	NN
cord-022594-fx044gcd	1155	7	in	in	IN
cord-022594-fx044gcd	1155	8	NMO	NMO	NNP
cord-022594-fx044gcd	1155	9	is	be	VBZ
cord-022594-fx044gcd	1155	10	in	in	IN
cord-022594-fx044gcd	1155	11	the	the	DT
cord-022594-fx044gcd	1155	12	planning	planning	NN
cord-022594-fx044gcd	1155	13	stages	stage	NNS
cord-022594-fx044gcd	1155	14	.	.	.
cord-022594-fx044gcd	1156	1	Supportive	supportive	JJ
cord-022594-fx044gcd	1156	2	care	care	NN
cord-022594-fx044gcd	1156	3	is	be	VBZ
cord-022594-fx044gcd	1156	4	important	important	JJ
cord-022594-fx044gcd	1156	5	in	in	IN
cord-022594-fx044gcd	1156	6	the	the	DT
cord-022594-fx044gcd	1156	7	management	management	NN
cord-022594-fx044gcd	1156	8	of	of	IN
cord-022594-fx044gcd	1156	9	NMO	NMO	NNP
cord-022594-fx044gcd	1156	10	.	.	.
cord-022594-fx044gcd	1157	1	These	these	DT
cord-022594-fx044gcd	1157	2	patients	patient	NNS
cord-022594-fx044gcd	1157	3	are	be	VBP
cord-022594-fx044gcd	1157	4	prone	prone	JJ
cord-022594-fx044gcd	1157	5	to	to	IN
cord-022594-fx044gcd	1157	6	many	many	JJ
cord-022594-fx044gcd	1157	7	complications	complication	NNS
cord-022594-fx044gcd	1157	8	and	and	CC
cord-022594-fx044gcd	1157	9	require	require	VB
cord-022594-fx044gcd	1157	10	measures	measure	NNS
cord-022594-fx044gcd	1157	11	to	to	TO
cord-022594-fx044gcd	1157	12	prevent	prevent	VB
cord-022594-fx044gcd	1157	13	deep	deep	JJ
cord-022594-fx044gcd	1157	14	venous	venous	JJ
cord-022594-fx044gcd	1157	15	thrombosis	thrombosis	NN
cord-022594-fx044gcd	1157	16	and	and	CC
cord-022594-fx044gcd	1157	17	pulmonary	pulmonary	JJ
cord-022594-fx044gcd	1157	18	embolism	embolism	NN
cord-022594-fx044gcd	1157	19	,	,	,
cord-022594-fx044gcd	1157	20	urinary	urinary	JJ
cord-022594-fx044gcd	1157	21	tract	tract	NN
cord-022594-fx044gcd	1157	22	infection	infection	NN
cord-022594-fx044gcd	1157	23	,	,	,
cord-022594-fx044gcd	1157	24	decubiti	decubiti	NNP
cord-022594-fx044gcd	1157	25	,	,	,
cord-022594-fx044gcd	1157	26	and	and	CC
cord-022594-fx044gcd	1157	27	contractures	contracture	NNS
cord-022594-fx044gcd	1157	28	.	.	.
cord-022594-fx044gcd	1158	1	Mechanical	mechanical	JJ
cord-022594-fx044gcd	1158	2	ventilation	ventilation	NN
cord-022594-fx044gcd	1158	3	may	may	MD
cord-022594-fx044gcd	1158	4	be	be	VB
cord-022594-fx044gcd	1158	5	needed	need	VBN
cord-022594-fx044gcd	1158	6	either	either	CC
cord-022594-fx044gcd	1158	7	temporarily	temporarily	RB
cord-022594-fx044gcd	1158	8	or	or	CC
cord-022594-fx044gcd	1158	9	permanently	permanently	RB
cord-022594-fx044gcd	1158	10	.	.	.
cord-022594-fx044gcd	1159	1	Patients	patient	NNS
cord-022594-fx044gcd	1159	2	with	with	IN
cord-022594-fx044gcd	1159	3	monophasic	monophasic	JJ
cord-022594-fx044gcd	1159	4	Devic	Devic	NNP
cord-022594-fx044gcd	1159	5	's	's	POS
cord-022594-fx044gcd	1159	6	syndrome	syndrome	NN
cord-022594-fx044gcd	1159	7	generally	generally	RB
cord-022594-fx044gcd	1159	8	have	have	VBP
cord-022594-fx044gcd	1159	9	simultaneous	simultaneous	JJ
cord-022594-fx044gcd	1159	10	or	or	CC
cord-022594-fx044gcd	1159	11	rapid	rapid	JJ
cord-022594-fx044gcd	1159	12	onset	onset	NN
cord-022594-fx044gcd	1159	13	of	of	IN
cord-022594-fx044gcd	1159	14	the	the	DT
cord-022594-fx044gcd	1159	15	ON	ON	NNP
cord-022594-fx044gcd	1159	16	and	and	CC
cord-022594-fx044gcd	1159	17	myelitis	myelitis	NNP
cord-022594-fx044gcd	1159	18	(	(	-LRB-
cord-022594-fx044gcd	1159	19	interval	interval	NN
cord-022594-fx044gcd	1159	20	usually	usually	RB
cord-022594-fx044gcd	1159	21	less	less	JJR
cord-022594-fx044gcd	1159	22	than	than	IN
cord-022594-fx044gcd	1159	23	1	1	CD
cord-022594-fx044gcd	1159	24	month	month	NN
cord-022594-fx044gcd	1159	25	)	)	-RRB-
cord-022594-fx044gcd	1159	26	.	.	.
cord-022594-fx044gcd	1160	1	Although	although	IN
cord-022594-fx044gcd	1160	2	some	some	DT
cord-022594-fx044gcd	1160	3	have	have	VBP
cord-022594-fx044gcd	1160	4	significant	significant	JJ
cord-022594-fx044gcd	1160	5	residual	residual	JJ
cord-022594-fx044gcd	1160	6	disability	disability	NN
cord-022594-fx044gcd	1160	7	,	,	,
cord-022594-fx044gcd	1160	8	many	many	JJ
cord-022594-fx044gcd	1160	9	recover	recover	VBP
cord-022594-fx044gcd	1160	10	remarkably	remarkably	RB
cord-022594-fx044gcd	1160	11	and	and	CC
cord-022594-fx044gcd	1160	12	have	have	VBP
cord-022594-fx044gcd	1160	13	little	little	JJ
cord-022594-fx044gcd	1160	14	or	or	CC
cord-022594-fx044gcd	1160	15	no	no	DT
cord-022594-fx044gcd	1160	16	permanent	permanent	JJ
cord-022594-fx044gcd	1160	17	deficits	deficit	NNS
cord-022594-fx044gcd	1160	18	.	.	.
cord-022594-fx044gcd	1161	1	A	a	DT
cord-022594-fx044gcd	1161	2	history	history	NN
cord-022594-fx044gcd	1161	3	of	of	IN
cord-022594-fx044gcd	1161	4	previous	previous	JJ
cord-022594-fx044gcd	1161	5	vague	vague	JJ
cord-022594-fx044gcd	1161	6	neurological	neurological	JJ
cord-022594-fx044gcd	1161	7	symptoms	symptom	NNS
cord-022594-fx044gcd	1161	8	or	or	CC
cord-022594-fx044gcd	1161	9	definite	definite	JJ
cord-022594-fx044gcd	1161	10	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1161	11	events	event	NNS
cord-022594-fx044gcd	1161	12	is	be	VBZ
cord-022594-fx044gcd	1161	13	predictive	predictive	JJ
cord-022594-fx044gcd	1161	14	of	of	IN
cord-022594-fx044gcd	1161	15	future	future	JJ
cord-022594-fx044gcd	1161	16	relapses	relapse	NNS
cord-022594-fx044gcd	1161	17	,	,	,
cord-022594-fx044gcd	1161	18	either	either	CC
cord-022594-fx044gcd	1161	19	typical	typical	JJ
cord-022594-fx044gcd	1161	20	of	of	IN
cord-022594-fx044gcd	1161	21	MS	MS	NNP
cord-022594-fx044gcd	1161	22	or	or	CC
cord-022594-fx044gcd	1161	23	relapsing	relapse	VBG
cord-022594-fx044gcd	1161	24	NMO	NMO	NNP
cord-022594-fx044gcd	1161	25	.	.	.
cord-022594-fx044gcd	1162	1	Those	those	DT
cord-022594-fx044gcd	1162	2	patients	patient	NNS
cord-022594-fx044gcd	1162	3	destined	destine	VBN
cord-022594-fx044gcd	1162	4	for	for	IN
cord-022594-fx044gcd	1162	5	recurrent	recurrent	JJ
cord-022594-fx044gcd	1162	6	myelitis	myelitis	NN
cord-022594-fx044gcd	1162	7	and	and	CC
cord-022594-fx044gcd	1162	8	ON	ON	NNP
cord-022594-fx044gcd	1162	9	have	have	VBP
cord-022594-fx044gcd	1162	10	a	a	DT
cord-022594-fx044gcd	1162	11	longer	long	JJR
cord-022594-fx044gcd	1162	12	interval	interval	NN
cord-022594-fx044gcd	1162	13	between	between	IN
cord-022594-fx044gcd	1162	14	the	the	DT
cord-022594-fx044gcd	1162	15	onsets	onset	NNS
cord-022594-fx044gcd	1162	16	of	of	IN
cord-022594-fx044gcd	1162	17	myelitis	myelitis	NNP
cord-022594-fx044gcd	1162	18	and	and	CC
cord-022594-fx044gcd	1162	19	ON	ON	NNP
cord-022594-fx044gcd	1162	20	.	.	.
cord-022594-fx044gcd	1163	1	The	the	DT
cord-022594-fx044gcd	1163	2	vast	vast	JJ
cord-022594-fx044gcd	1163	3	majority	majority	NN
cord-022594-fx044gcd	1163	4	of	of	IN
cord-022594-fx044gcd	1163	5	patients	patient	NNS
cord-022594-fx044gcd	1163	6	with	with	IN
cord-022594-fx044gcd	1163	7	relapsing	relapse	VBG
cord-022594-fx044gcd	1163	8	NMO	NMO	NNP
cord-022594-fx044gcd	1163	9	have	have	VBP
cord-022594-fx044gcd	1163	10	very	very	RB
cord-022594-fx044gcd	1163	11	aggressive	aggressive	JJ
cord-022594-fx044gcd	1163	12	disease	disease	NN
cord-022594-fx044gcd	1163	13	with	with	IN
cord-022594-fx044gcd	1163	14	frequent	frequent	JJ
cord-022594-fx044gcd	1163	15	and	and	CC
cord-022594-fx044gcd	1163	16	severe	severe	JJ
cord-022594-fx044gcd	1163	17	exacerbations	exacerbation	NNS
cord-022594-fx044gcd	1163	18	and	and	CC
cord-022594-fx044gcd	1163	19	a	a	DT
cord-022594-fx044gcd	1163	20	poor	poor	JJ
cord-022594-fx044gcd	1163	21	prognosis	prognosis	NN
cord-022594-fx044gcd	1163	22	.	.	.
cord-022594-fx044gcd	1163	23	 	 	_SP
cord-022594-fx044gcd	1164	1	ADEM	ADEM	NNP
cord-022594-fx044gcd	1164	2	is	be	VBZ
cord-022594-fx044gcd	1164	3	a	a	DT
cord-022594-fx044gcd	1164	4	monophasic	monophasic	JJ
cord-022594-fx044gcd	1164	5	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1164	6	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1164	7	disorder	disorder	NN
cord-022594-fx044gcd	1164	8	that	that	WDT
cord-022594-fx044gcd	1164	9	characteristically	characteristically	RB
cord-022594-fx044gcd	1164	10	begins	begin	VBZ
cord-022594-fx044gcd	1164	11	within	within	IN
cord-022594-fx044gcd	1164	12	6	6	CD
cord-022594-fx044gcd	1164	13	weeks	week	NNS
cord-022594-fx044gcd	1164	14	of	of	IN
cord-022594-fx044gcd	1164	15	an	an	DT
cord-022594-fx044gcd	1164	16	antigenic	antigenic	JJ
cord-022594-fx044gcd	1164	17	challenge	challenge	NN
cord-022594-fx044gcd	1164	18	such	such	JJ
cord-022594-fx044gcd	1164	19	as	as	IN
cord-022594-fx044gcd	1164	20	infection	infection	NN
cord-022594-fx044gcd	1164	21	or	or	CC
cord-022594-fx044gcd	1164	22	immunization	immunization	NN
cord-022594-fx044gcd	1164	23	.	.	.
cord-022594-fx044gcd	1165	1	It	-PRON-	PRP
cord-022594-fx044gcd	1165	2	occurs	occur	VBZ
cord-022594-fx044gcd	1165	3	more	more	RBR
cord-022594-fx044gcd	1165	4	often	often	RB
cord-022594-fx044gcd	1165	5	in	in	IN
cord-022594-fx044gcd	1165	6	the	the	DT
cord-022594-fx044gcd	1165	7	young	young	JJ
cord-022594-fx044gcd	1165	8	and	and	CC
cord-022594-fx044gcd	1165	9	causes	cause	VBZ
cord-022594-fx044gcd	1165	10	the	the	DT
cord-022594-fx044gcd	1165	11	rapid	rapid	JJ
cord-022594-fx044gcd	1165	12	development	development	NN
cord-022594-fx044gcd	1165	13	of	of	IN
cord-022594-fx044gcd	1165	14	multifocal	multifocal	JJ
cord-022594-fx044gcd	1165	15	or	or	CC
cord-022594-fx044gcd	1165	16	focal	focal	JJ
cord-022594-fx044gcd	1165	17	neurological	neurological	JJ
cord-022594-fx044gcd	1165	18	deficits	deficit	NNS
cord-022594-fx044gcd	1165	19	.	.	.
cord-022594-fx044gcd	1166	1	Perivenous	Perivenous	NNP
cord-022594-fx044gcd	1166	2	inflammation	inflammation	NN
cord-022594-fx044gcd	1166	3	,	,	,
cord-022594-fx044gcd	1166	4	edema	edema	NN
cord-022594-fx044gcd	1166	5	,	,	,
cord-022594-fx044gcd	1166	6	and	and	CC
cord-022594-fx044gcd	1166	7	demyelination	demyelination	NN
cord-022594-fx044gcd	1166	8	are	be	VBP
cord-022594-fx044gcd	1166	9	the	the	DT
cord-022594-fx044gcd	1166	10	pathological	pathological	JJ
cord-022594-fx044gcd	1166	11	hallmarks	hallmark	NNS
cord-022594-fx044gcd	1166	12	of	of	IN
cord-022594-fx044gcd	1166	13	ADEM	ADEM	NNP
cord-022594-fx044gcd	1166	14	,	,	,
cord-022594-fx044gcd	1166	15	although	although	IN
cord-022594-fx044gcd	1166	16	these	these	DT
cord-022594-fx044gcd	1166	17	lesions	lesion	NNS
cord-022594-fx044gcd	1166	18	commonly	commonly	RB
cord-022594-fx044gcd	1166	19	enlarge	enlarge	VBP
cord-022594-fx044gcd	1166	20	and	and	CC
cord-022594-fx044gcd	1166	21	coalesce	coalesce	VBP
cord-022594-fx044gcd	1166	22	,	,	,
cord-022594-fx044gcd	1166	23	forming	form	VBG
cord-022594-fx044gcd	1166	24	lesions	lesion	NNS
cord-022594-fx044gcd	1166	25	pathologically	pathologically	RB
cord-022594-fx044gcd	1166	26	indistinguishable	indistinguishable	JJ
cord-022594-fx044gcd	1166	27	from	from	IN
cord-022594-fx044gcd	1166	28	MS	MS	NNP
cord-022594-fx044gcd	1166	29	.	.	.
cord-022594-fx044gcd	1167	1	Moreover	moreover	RB
cord-022594-fx044gcd	1167	2	,	,	,
cord-022594-fx044gcd	1167	3	perivascular	perivascular	NNP
cord-022594-fx044gcd	1167	4	changes	change	VBZ
cord-022594-fx044gcd	1167	5	typical	typical	JJ
cord-022594-fx044gcd	1167	6	of	of	IN
cord-022594-fx044gcd	1167	7	ADEM	ADEM	NNP
cord-022594-fx044gcd	1167	8	are	be	VBP
cord-022594-fx044gcd	1167	9	common	common	JJ
cord-022594-fx044gcd	1167	10	in	in	IN
cord-022594-fx044gcd	1167	11	patients	patient	NNS
cord-022594-fx044gcd	1167	12	with	with	IN
cord-022594-fx044gcd	1167	13	MS	MS	NNP
cord-022594-fx044gcd	1167	14	.	.	.
cord-022594-fx044gcd	1168	1	There	there	EX
cord-022594-fx044gcd	1168	2	is	be	VBZ
cord-022594-fx044gcd	1168	3	considerable	considerable	JJ
cord-022594-fx044gcd	1168	4	overlap	overlap	NN
cord-022594-fx044gcd	1168	5	in	in	IN
cord-022594-fx044gcd	1168	6	the	the	DT
cord-022594-fx044gcd	1168	7	epidemiological	epidemiological	JJ
cord-022594-fx044gcd	1168	8	,	,	,
cord-022594-fx044gcd	1168	9	clinical	clinical	JJ
cord-022594-fx044gcd	1168	10	,	,	,
cord-022594-fx044gcd	1168	11	CSF	CSF	NNP
cord-022594-fx044gcd	1168	12	,	,	,
cord-022594-fx044gcd	1168	13	imaging	imaging	NN
cord-022594-fx044gcd	1168	14	,	,	,
cord-022594-fx044gcd	1168	15	and	and	CC
cord-022594-fx044gcd	1168	16	pathological	pathological	JJ
cord-022594-fx044gcd	1168	17	features	feature	NNS
cord-022594-fx044gcd	1168	18	between	between	IN
cord-022594-fx044gcd	1168	19	ADEM	ADEM	NNP
cord-022594-fx044gcd	1168	20	and	and	CC
cord-022594-fx044gcd	1168	21	MS	MS	NNP
cord-022594-fx044gcd	1168	22	,	,	,
cord-022594-fx044gcd	1168	23	often	often	RB
cord-022594-fx044gcd	1168	24	making	make	VBG
cord-022594-fx044gcd	1168	25	it	-PRON-	PRP
cord-022594-fx044gcd	1168	26	difficult	difficult	JJ
cord-022594-fx044gcd	1168	27	to	to	TO
cord-022594-fx044gcd	1168	28	distinguish	distinguish	VB
cord-022594-fx044gcd	1168	29	between	between	IN
cord-022594-fx044gcd	1168	30	the	the	DT
cord-022594-fx044gcd	1168	31	two	two	CD
cord-022594-fx044gcd	1168	32	with	with	IN
cord-022594-fx044gcd	1168	33	reasonable	reasonable	JJ
cord-022594-fx044gcd	1168	34	confidence	confidence	NN
cord-022594-fx044gcd	1168	35	when	when	WRB
cord-022594-fx044gcd	1168	36	encountering	encounter	VBG
cord-022594-fx044gcd	1168	37	patients	patient	NNS
cord-022594-fx044gcd	1168	38	with	with	IN
cord-022594-fx044gcd	1168	39	a	a	DT
cord-022594-fx044gcd	1168	40	single	single	JJ
cord-022594-fx044gcd	1168	41	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1168	42	event	event	NN
cord-022594-fx044gcd	1168	43	.	.	.
cord-022594-fx044gcd	1169	1	PATHOGENESIS	PATHOGENESIS	NNP
cord-022594-fx044gcd	1169	2	AND	and	CC
cord-022594-fx044gcd	1169	3	PATHOPHYSIOLOGY	PATHOPHYSIOLOGY	NNP
cord-022594-fx044gcd	1169	4	.	.	.
cord-022594-fx044gcd	1170	1	ADEM	ADEM	NNP
cord-022594-fx044gcd	1170	2	closely	closely	RB
cord-022594-fx044gcd	1170	3	resembles	resemble	VBZ
cord-022594-fx044gcd	1170	4	the	the	DT
cord-022594-fx044gcd	1170	5	experimental	experimental	JJ
cord-022594-fx044gcd	1170	6	allergic	allergic	JJ
cord-022594-fx044gcd	1170	7	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	1170	8	animal	animal	NN
cord-022594-fx044gcd	1170	9	model	model	NN
cord-022594-fx044gcd	1170	10	of	of	IN
cord-022594-fx044gcd	1170	11	MS	MS	NNP
cord-022594-fx044gcd	1170	12	(	(	-LRB-
cord-022594-fx044gcd	1170	13	EAE	EAE	NNP
cord-022594-fx044gcd	1170	14	)	)	-RRB-
cord-022594-fx044gcd	1170	15	both	both	CC
cord-022594-fx044gcd	1170	16	clinically	clinically	RB
cord-022594-fx044gcd	1170	17	and	and	CC
cord-022594-fx044gcd	1170	18	pathologically	pathologically	RB
cord-022594-fx044gcd	1170	19	,	,	,
cord-022594-fx044gcd	1170	20	and	and	CC
cord-022594-fx044gcd	1170	21	is	be	VBZ
cord-022594-fx044gcd	1170	22	most	most	RBS
cord-022594-fx044gcd	1170	23	likely	likely	JJ
cord-022594-fx044gcd	1170	24	due	due	IN
cord-022594-fx044gcd	1170	25	to	to	IN
cord-022594-fx044gcd	1170	26	a	a	DT
cord-022594-fx044gcd	1170	27	transient	transient	JJ
cord-022594-fx044gcd	1170	28	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1170	29	response	response	NN
cord-022594-fx044gcd	1170	30	toward	toward	IN
cord-022594-fx044gcd	1170	31	myelin	myelin	NN
cord-022594-fx044gcd	1170	32	.	.	.
cord-022594-fx044gcd	1171	1	The	the	DT
cord-022594-fx044gcd	1171	2	occurrence	occurrence	NN
cord-022594-fx044gcd	1171	3	of	of	IN
cord-022594-fx044gcd	1171	4	ADEM	ADEM	NNP
cord-022594-fx044gcd	1171	5	after	after	IN
cord-022594-fx044gcd	1171	6	vaccination	vaccination	NN
cord-022594-fx044gcd	1171	7	with	with	IN
cord-022594-fx044gcd	1171	8	the	the	DT
cord-022594-fx044gcd	1171	9	rabbit	rabbit	NN
cord-022594-fx044gcd	1171	10	spinal	spinal	JJ
cord-022594-fx044gcd	1171	11	cord	cord	NN
cord-022594-fx044gcd	1171	12	preparation	preparation	NN
cord-022594-fx044gcd	1171	13	of	of	IN
cord-022594-fx044gcd	1171	14	rabies	rabie	NNS
cord-022594-fx044gcd	1171	15	virus	virus	NN
cord-022594-fx044gcd	1171	16	led	lead	VBN
cord-022594-fx044gcd	1171	17	to	to	IN
cord-022594-fx044gcd	1171	18	the	the	DT
cord-022594-fx044gcd	1171	19	discovery	discovery	NN
cord-022594-fx044gcd	1171	20	of	of	IN
cord-022594-fx044gcd	1171	21	EAE	EAE	NNP
cord-022594-fx044gcd	1171	22	.	.	.
cord-022594-fx044gcd	1172	1	Infections	infection	NNS
cord-022594-fx044gcd	1172	2	and	and	CC
cord-022594-fx044gcd	1172	3	non	non	JJ
cord-022594-fx044gcd	1172	4	-	-	JJ
cord-022594-fx044gcd	1172	5	CNScontaining	cnscontaining	JJ
cord-022594-fx044gcd	1172	6	vaccinations	vaccination	NNS
cord-022594-fx044gcd	1172	7	may	may	MD
cord-022594-fx044gcd	1172	8	induce	induce	VB
cord-022594-fx044gcd	1172	9	ADEM	ADEM	NNP
cord-022594-fx044gcd	1172	10	by	by	IN
cord-022594-fx044gcd	1172	11	molecular	molecular	JJ
cord-022594-fx044gcd	1172	12	mimicry	mimicry	NN
cord-022594-fx044gcd	1172	13	or	or	CC
cord-022594-fx044gcd	1172	14	by	by	IN
cord-022594-fx044gcd	1172	15	activating	activate	VBG
cord-022594-fx044gcd	1172	16	autoreactive	autoreactive	JJ
cord-022594-fx044gcd	1172	17	T	t	NN
cord-022594-fx044gcd	1172	18	-	-	HYPH
cord-022594-fx044gcd	1172	19	cell	cell	NN
cord-022594-fx044gcd	1172	20	clones	clone	NNS
cord-022594-fx044gcd	1172	21	in	in	IN
cord-022594-fx044gcd	1172	22	a	a	DT
cord-022594-fx044gcd	1172	23	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	1172	24	manner	manner	NN
cord-022594-fx044gcd	1172	25	.	.	.
cord-022594-fx044gcd	1173	1	Lymphocyte	lymphocyte	NN
cord-022594-fx044gcd	1173	2	reactivity	reactivity	NN
cord-022594-fx044gcd	1173	3	toward	toward	IN
cord-022594-fx044gcd	1173	4	MBP	MBP	NNP
cord-022594-fx044gcd	1173	5	has	have	VBZ
cord-022594-fx044gcd	1173	6	been	be	VBN
cord-022594-fx044gcd	1173	7	identified	identify	VBN
cord-022594-fx044gcd	1173	8	in	in	IN
cord-022594-fx044gcd	1173	9	blood	blood	NN
cord-022594-fx044gcd	1173	10	and	and	CC
cord-022594-fx044gcd	1173	11	CSF	csf	NN
cord-022594-fx044gcd	1173	12	from	from	IN
cord-022594-fx044gcd	1173	13	patients	patient	NNS
cord-022594-fx044gcd	1173	14	with	with	IN
cord-022594-fx044gcd	1173	15	ADEM	ADEM	NNP
cord-022594-fx044gcd	1173	16	,	,	,
cord-022594-fx044gcd	1173	17	but	but	CC
cord-022594-fx044gcd	1173	18	its	-PRON-	PRP$
cord-022594-fx044gcd	1173	19	absence	absence	NN
cord-022594-fx044gcd	1173	20	in	in	IN
cord-022594-fx044gcd	1173	21	others	other	NNS
cord-022594-fx044gcd	1173	22	indicates	indicate	VBZ
cord-022594-fx044gcd	1173	23	a	a	DT
cord-022594-fx044gcd	1173	24	role	role	NN
cord-022594-fx044gcd	1173	25	for	for	IN
cord-022594-fx044gcd	1173	26	other	other	JJ
cord-022594-fx044gcd	1173	27	antigens	antigen	NNS
cord-022594-fx044gcd	1173	28	.	.	.
cord-022594-fx044gcd	1174	1	Increased	increase	VBN
cord-022594-fx044gcd	1174	2	peripheral	peripheral	JJ
cord-022594-fx044gcd	1174	3	blood	blood	NN
cord-022594-fx044gcd	1174	4	g	g	NN
cord-022594-fx044gcd	1174	5	interferon	interferon	NN
cord-022594-fx044gcd	1174	6	-	-	HYPH
cord-022594-fx044gcd	1174	7	producing	produce	VBG
cord-022594-fx044gcd	1174	8	T	t	NN
cord-022594-fx044gcd	1174	9	cells	cell	NNS
cord-022594-fx044gcd	1174	10	have	have	VBP
cord-022594-fx044gcd	1174	11	been	be	VBN
cord-022594-fx044gcd	1174	12	described	describe	VBN
cord-022594-fx044gcd	1174	13	in	in	IN
cord-022594-fx044gcd	1174	14	ADEM	ADEM	NNP
cord-022594-fx044gcd	1174	15	.	.	.
cord-022594-fx044gcd	1175	1	EPIDEMIOLOGY	EPIDEMIOLOGY	NNP
cord-022594-fx044gcd	1175	2	AND	and	CC
cord-022594-fx044gcd	1175	3	RISK	risk	NN
cord-022594-fx044gcd	1175	4	FACTORS	factors	NN
cord-022594-fx044gcd	1175	5	.	.	.
cord-022594-fx044gcd	1176	1	ADEM	ADEM	NNP
cord-022594-fx044gcd	1176	2	can	can	MD
cord-022594-fx044gcd	1176	3	occur	occur	VB
cord-022594-fx044gcd	1176	4	at	at	IN
cord-022594-fx044gcd	1176	5	any	any	DT
cord-022594-fx044gcd	1176	6	age	age	NN
cord-022594-fx044gcd	1176	7	but	but	CC
cord-022594-fx044gcd	1176	8	perhaps	perhaps	RB
cord-022594-fx044gcd	1176	9	because	because	IN
cord-022594-fx044gcd	1176	10	of	of	IN
cord-022594-fx044gcd	1176	11	the	the	DT
cord-022594-fx044gcd	1176	12	higher	high	JJR
cord-022594-fx044gcd	1176	13	frequency	frequency	NN
cord-022594-fx044gcd	1176	14	of	of	IN
cord-022594-fx044gcd	1176	15	immunization	immunization	NN
cord-022594-fx044gcd	1176	16	and	and	CC
cord-022594-fx044gcd	1176	17	exposure	exposure	NN
cord-022594-fx044gcd	1176	18	to	to	IN
cord-022594-fx044gcd	1176	19	new	new	JJ
cord-022594-fx044gcd	1176	20	antigens	antigen	NNS
cord-022594-fx044gcd	1176	21	;	;	:
cord-022594-fx044gcd	1176	22	it	-PRON-	PRP
cord-022594-fx044gcd	1176	23	is	be	VBZ
cord-022594-fx044gcd	1176	24	most	most	RBS
cord-022594-fx044gcd	1176	25	common	common	JJ
cord-022594-fx044gcd	1176	26	during	during	IN
cord-022594-fx044gcd	1176	27	childhood	childhood	NN
cord-022594-fx044gcd	1176	28	.	.	.
cord-022594-fx044gcd	1177	1	Unlike	unlike	IN
cord-022594-fx044gcd	1177	2	MS	MS	NNP
cord-022594-fx044gcd	1177	3	,	,	,
cord-022594-fx044gcd	1177	4	both	both	DT
cord-022594-fx044gcd	1177	5	sexes	sex	NNS
cord-022594-fx044gcd	1177	6	are	be	VBP
cord-022594-fx044gcd	1177	7	affected	affect	VBN
cord-022594-fx044gcd	1177	8	with	with	IN
cord-022594-fx044gcd	1177	9	equal	equal	JJ
cord-022594-fx044gcd	1177	10	frequency	frequency	NN
cord-022594-fx044gcd	1177	11	.	.	.
cord-022594-fx044gcd	1178	1	No	no	DT
cord-022594-fx044gcd	1178	2	association	association	NN
cord-022594-fx044gcd	1178	3	has	have	VBZ
cord-022594-fx044gcd	1178	4	been	be	VBN
cord-022594-fx044gcd	1178	5	noted	note	VBN
cord-022594-fx044gcd	1178	6	with	with	IN
cord-022594-fx044gcd	1178	7	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1178	8	.	.	.
cord-022594-fx044gcd	1179	1	ADEM	ADEM	NNP
cord-022594-fx044gcd	1179	2	has	have	VBZ
cord-022594-fx044gcd	1179	3	been	be	VBN
cord-022594-fx044gcd	1179	4	reported	report	VBN
cord-022594-fx044gcd	1179	5	to	to	TO
cord-022594-fx044gcd	1179	6	follow	follow	VB
cord-022594-fx044gcd	1179	7	a	a	DT
cord-022594-fx044gcd	1179	8	number	number	NN
cord-022594-fx044gcd	1179	9	of	of	IN
cord-022594-fx044gcd	1179	10	different	different	JJ
cord-022594-fx044gcd	1179	11	immunizations	immunization	NNS
cord-022594-fx044gcd	1179	12	,	,	,
cord-022594-fx044gcd	1179	13	usually	usually	RB
cord-022594-fx044gcd	1179	14	within	within	IN
cord-022594-fx044gcd	1179	15	6	6	CD
cord-022594-fx044gcd	1179	16	weeks	week	NNS
cord-022594-fx044gcd	1179	17	,	,	,
cord-022594-fx044gcd	1179	18	including	include	VBG
cord-022594-fx044gcd	1179	19	those	those	DT
cord-022594-fx044gcd	1179	20	for	for	IN
cord-022594-fx044gcd	1179	21	pertussis	pertussis	NN
cord-022594-fx044gcd	1179	22	,	,	,
cord-022594-fx044gcd	1179	23	diphtheria	diphtheria	NN
cord-022594-fx044gcd	1179	24	,	,	,
cord-022594-fx044gcd	1179	25	measles	measle	NNS
cord-022594-fx044gcd	1179	26	,	,	,
cord-022594-fx044gcd	1179	27	mumps	mumps	NN
cord-022594-fx044gcd	1179	28	,	,	,
cord-022594-fx044gcd	1179	29	rubella	rubella	NN
cord-022594-fx044gcd	1179	30	,	,	,
cord-022594-fx044gcd	1179	31	influenza	influenza	NN
cord-022594-fx044gcd	1179	32	(	(	-LRB-
cord-022594-fx044gcd	1179	33	postvaccination	postvaccination	NNP
cord-022594-fx044gcd	1179	34	ADEM	ADEM	NNP
cord-022594-fx044gcd	1179	35	)	)	-RRB-
cord-022594-fx044gcd	1179	36	,	,	,
cord-022594-fx044gcd	1179	37	tetanus	tetanus	NN
cord-022594-fx044gcd	1179	38	,	,	,
cord-022594-fx044gcd	1179	39	and	and	CC
cord-022594-fx044gcd	1179	40	yellow	yellow	JJ
cord-022594-fx044gcd	1179	41	fever	fever	NN
cord-022594-fx044gcd	1179	42	.	.	.
cord-022594-fx044gcd	1180	1	In	in	IN
cord-022594-fx044gcd	1180	2	addition	addition	NN
cord-022594-fx044gcd	1180	3	,	,	,
cord-022594-fx044gcd	1180	4	there	there	EX
cord-022594-fx044gcd	1180	5	are	be	VBP
cord-022594-fx044gcd	1180	6	case	case	NN
cord-022594-fx044gcd	1180	7	reports	report	NNS
cord-022594-fx044gcd	1180	8	of	of	IN
cord-022594-fx044gcd	1180	9	ADEM	ADEM	NNP
cord-022594-fx044gcd	1180	10	following	follow	VBG
cord-022594-fx044gcd	1180	11	hepatitis	hepatitis	NNP
cord-022594-fx044gcd	1180	12	B	B	NNP
cord-022594-fx044gcd	1180	13	vaccination	vaccination	NN
cord-022594-fx044gcd	1180	14	.	.	.
cord-022594-fx044gcd	1181	1	However	however	RB
cord-022594-fx044gcd	1181	2	,	,	,
cord-022594-fx044gcd	1181	3	the	the	DT
cord-022594-fx044gcd	1181	4	only	only	JJ
cord-022594-fx044gcd	1181	5	epidemiologically	epidemiologically	RB
cord-022594-fx044gcd	1181	6	and	and	CC
cord-022594-fx044gcd	1181	7	pathologically	pathologically	RB
cord-022594-fx044gcd	1181	8	proved	proved	JJ
cord-022594-fx044gcd	1181	9	association	association	NN
cord-022594-fx044gcd	1181	10	is	be	VBZ
cord-022594-fx044gcd	1181	11	with	with	IN
cord-022594-fx044gcd	1181	12	rabies	rabies	NN
cord-022594-fx044gcd	1181	13	vaccination	vaccination	NN
cord-022594-fx044gcd	1181	14	,	,	,
cord-022594-fx044gcd	1181	15	which	which	WDT
cord-022594-fx044gcd	1181	16	also	also	RB
cord-022594-fx044gcd	1181	17	causes	cause	VBZ
cord-022594-fx044gcd	1181	18	demyelinating	demyelinate	VBG
cord-022594-fx044gcd	1181	19	peripheral	peripheral	JJ
cord-022594-fx044gcd	1181	20	neuropathies	neuropathy	NNS
cord-022594-fx044gcd	1181	21	.	.	.
cord-022594-fx044gcd	1182	1	The	the	DT
cord-022594-fx044gcd	1182	2	original	original	JJ
cord-022594-fx044gcd	1182	3	Pasteur	Pasteur	NNP
cord-022594-fx044gcd	1182	4	rabies	rabie	NNS
cord-022594-fx044gcd	1182	5	vaccine	vaccine	NN
cord-022594-fx044gcd	1182	6	,	,	,
cord-022594-fx044gcd	1182	7	prepared	prepare	VBN
cord-022594-fx044gcd	1182	8	in	in	IN
cord-022594-fx044gcd	1182	9	rabbit	rabbit	NN
cord-022594-fx044gcd	1182	10	spinal	spinal	JJ
cord-022594-fx044gcd	1182	11	cord	cord	NN
cord-022594-fx044gcd	1182	12	,	,	,
cord-022594-fx044gcd	1182	13	was	be	VBD
cord-022594-fx044gcd	1182	14	associated	associate	VBN
cord-022594-fx044gcd	1182	15	with	with	IN
cord-022594-fx044gcd	1182	16	an	an	DT
cord-022594-fx044gcd	1182	17	incidence	incidence	NN
cord-022594-fx044gcd	1182	18	of	of	IN
cord-022594-fx044gcd	1182	19	ADEM	ADEM	NNP
cord-022594-fx044gcd	1182	20	of	of	IN
cord-022594-fx044gcd	1182	21	approximately	approximately	RB
cord-022594-fx044gcd	1182	22	1	1	CD
cord-022594-fx044gcd	1182	23	per	per	IN
cord-022594-fx044gcd	1182	24	3000	3000	CD
cord-022594-fx044gcd	1182	25	to	to	IN
cord-022594-fx044gcd	1182	26	1	1	CD
cord-022594-fx044gcd	1182	27	per	per	IN
cord-022594-fx044gcd	1182	28	35,000	35,000	CD
cord-022594-fx044gcd	1182	29	vaccinations	vaccination	NNS
cord-022594-fx044gcd	1182	30	and	and	CC
cord-022594-fx044gcd	1182	31	is	be	VBZ
cord-022594-fx044gcd	1182	32	no	no	DT
cord-022594-fx044gcd	1182	33	longer	long	RBR
cord-022594-fx044gcd	1182	34	in	in	IN
cord-022594-fx044gcd	1182	35	use	use	NN
cord-022594-fx044gcd	1182	36	.	.	.
cord-022594-fx044gcd	1183	1	A	a	DT
cord-022594-fx044gcd	1183	2	later	later	JJ
cord-022594-fx044gcd	1183	3	vaccine	vaccine	NN
cord-022594-fx044gcd	1183	4	,	,	,
cord-022594-fx044gcd	1183	5	made	make	VBN
cord-022594-fx044gcd	1183	6	in	in	IN
cord-022594-fx044gcd	1183	7	duck	duck	NN
cord-022594-fx044gcd	1183	8	embryo	embryo	NN
cord-022594-fx044gcd	1183	9	,	,	,
cord-022594-fx044gcd	1183	10	which	which	WDT
cord-022594-fx044gcd	1183	11	contains	contain	VBZ
cord-022594-fx044gcd	1183	12	little	little	JJ
cord-022594-fx044gcd	1183	13	neural	neural	JJ
cord-022594-fx044gcd	1183	14	tissue	tissue	NN
cord-022594-fx044gcd	1183	15	,	,	,
cord-022594-fx044gcd	1183	16	carries	carry	VBZ
cord-022594-fx044gcd	1183	17	a	a	DT
cord-022594-fx044gcd	1183	18	risk	risk	NN
cord-022594-fx044gcd	1183	19	for	for	IN
cord-022594-fx044gcd	1183	20	ADEM	ADEM	NNP
cord-022594-fx044gcd	1183	21	of	of	IN
cord-022594-fx044gcd	1183	22	1	1	CD
cord-022594-fx044gcd	1183	23	per	per	IN
cord-022594-fx044gcd	1183	24	25,000	25,000	CD
cord-022594-fx044gcd	1183	25	vaccines	vaccine	NNS
cord-022594-fx044gcd	1183	26	.	.	.
cord-022594-fx044gcd	1184	1	The	the	DT
cord-022594-fx044gcd	1184	2	use	use	NN
cord-022594-fx044gcd	1184	3	of	of	IN
cord-022594-fx044gcd	1184	4	human	human	JJ
cord-022594-fx044gcd	1184	5	diploid	diploid	JJ
cord-022594-fx044gcd	1184	6	cell	cell	NN
cord-022594-fx044gcd	1184	7	lines	line	NNS
cord-022594-fx044gcd	1184	8	,	,	,
cord-022594-fx044gcd	1184	9	which	which	WDT
cord-022594-fx044gcd	1184	10	contain	contain	VBP
cord-022594-fx044gcd	1184	11	no	no	DT
cord-022594-fx044gcd	1184	12	nervous	nervous	JJ
cord-022594-fx044gcd	1184	13	system	system	NN
cord-022594-fx044gcd	1184	14	tissue	tissue	NN
cord-022594-fx044gcd	1184	15	,	,	,
cord-022594-fx044gcd	1184	16	for	for	IN
cord-022594-fx044gcd	1184	17	the	the	DT
cord-022594-fx044gcd	1184	18	production	production	NN
cord-022594-fx044gcd	1184	19	of	of	IN
cord-022594-fx044gcd	1184	20	rabies	rabie	VBN
cord-022594-fx044gcd	1184	21	vaccine	vaccine	NN
cord-022594-fx044gcd	1184	22	has	have	VBZ
cord-022594-fx044gcd	1184	23	virtually	virtually	RB
cord-022594-fx044gcd	1184	24	eliminated	eliminate	VBN
cord-022594-fx044gcd	1184	25	the	the	DT
cord-022594-fx044gcd	1184	26	risk	risk	NN
cord-022594-fx044gcd	1184	27	of	of	IN
cord-022594-fx044gcd	1184	28	ADEM	ADEM	NNP
cord-022594-fx044gcd	1184	29	.	.	.
cord-022594-fx044gcd	1185	1	The	the	DT
cord-022594-fx044gcd	1185	2	association	association	NN
cord-022594-fx044gcd	1185	3	of	of	IN
cord-022594-fx044gcd	1185	4	bee	bee	NNP
cord-022594-fx044gcd	1185	5	stings	sting	VBZ
cord-022594-fx044gcd	1185	6	with	with	IN
cord-022594-fx044gcd	1185	7	ADEM	ADEM	NNP
cord-022594-fx044gcd	1185	8	has	have	VBZ
cord-022594-fx044gcd	1185	9	also	also	RB
cord-022594-fx044gcd	1185	10	been	be	VBN
cord-022594-fx044gcd	1185	11	reported	report	VBN
cord-022594-fx044gcd	1185	12	.	.	.
cord-022594-fx044gcd	1186	1	Parainfectious	Parainfectious	NNP
cord-022594-fx044gcd	1186	2	ADEM	ADEM	NNP
cord-022594-fx044gcd	1186	3	usually	usually	RB
cord-022594-fx044gcd	1186	4	follows	follow	VBZ
cord-022594-fx044gcd	1186	5	onset	onset	NN
cord-022594-fx044gcd	1186	6	of	of	IN
cord-022594-fx044gcd	1186	7	the	the	DT
cord-022594-fx044gcd	1186	8	infectious	infectious	JJ
cord-022594-fx044gcd	1186	9	illness	illness	NN
cord-022594-fx044gcd	1186	10	,	,	,
cord-022594-fx044gcd	1186	11	often	often	RB
cord-022594-fx044gcd	1186	12	during	during	IN
cord-022594-fx044gcd	1186	13	the	the	DT
cord-022594-fx044gcd	1186	14	recovery	recovery	NN
cord-022594-fx044gcd	1186	15	phase	phase	NN
cord-022594-fx044gcd	1186	16	,	,	,
cord-022594-fx044gcd	1186	17	but	but	CC
cord-022594-fx044gcd	1186	18	because	because	IN
cord-022594-fx044gcd	1186	19	of	of	IN
cord-022594-fx044gcd	1186	20	the	the	DT
cord-022594-fx044gcd	1186	21	latency	latency	NN
cord-022594-fx044gcd	1186	22	between	between	IN
cord-022594-fx044gcd	1186	23	pathogen	pathogen	NN
cord-022594-fx044gcd	1186	24	exposure	exposure	NN
cord-022594-fx044gcd	1186	25	and	and	CC
cord-022594-fx044gcd	1186	26	illness	illness	NN
cord-022594-fx044gcd	1186	27	it	-PRON-	PRP
cord-022594-fx044gcd	1186	28	may	may	MD
cord-022594-fx044gcd	1186	29	precede	precede	VB
cord-022594-fx044gcd	1186	30	clinical	clinical	JJ
cord-022594-fx044gcd	1186	31	symptoms	symptom	NNS
cord-022594-fx044gcd	1186	32	of	of	IN
cord-022594-fx044gcd	1186	33	infection	infection	NN
cord-022594-fx044gcd	1186	34	or	or	CC
cord-022594-fx044gcd	1186	35	the	the	DT
cord-022594-fx044gcd	1186	36	two	two	CD
cord-022594-fx044gcd	1186	37	may	may	MD
cord-022594-fx044gcd	1186	38	occur	occur	VB
cord-022594-fx044gcd	1186	39	simultaneously	simultaneously	RB
cord-022594-fx044gcd	1186	40	.	.	.
cord-022594-fx044gcd	1187	1	The	the	DT
cord-022594-fx044gcd	1187	2	most	most	RBS
cord-022594-fx044gcd	1187	3	commonly	commonly	RB
cord-022594-fx044gcd	1187	4	reported	report	VBN
cord-022594-fx044gcd	1187	5	associated	associated	JJ
cord-022594-fx044gcd	1187	6	illness	illness	NN
cord-022594-fx044gcd	1187	7	is	be	VBZ
cord-022594-fx044gcd	1187	8	a	a	DT
cord-022594-fx044gcd	1187	9	nonspecific	nonspecific	JJ
cord-022594-fx044gcd	1187	10	upper	upper	JJ
cord-022594-fx044gcd	1187	11	respiratory	respiratory	JJ
cord-022594-fx044gcd	1187	12	tract	tract	NN
cord-022594-fx044gcd	1187	13	infection	infection	NN
cord-022594-fx044gcd	1187	14	.	.	.
cord-022594-fx044gcd	1188	1	There	there	EX
cord-022594-fx044gcd	1188	2	have	have	VBP
cord-022594-fx044gcd	1188	3	been	be	VBN
cord-022594-fx044gcd	1188	4	a	a	DT
cord-022594-fx044gcd	1188	5	vast	vast	JJ
cord-022594-fx044gcd	1188	6	number	number	NN
cord-022594-fx044gcd	1188	7	of	of	IN
cord-022594-fx044gcd	1188	8	specific	specific	JJ
cord-022594-fx044gcd	1188	9	infections	infection	NNS
cord-022594-fx044gcd	1188	10	associated	associate	VBN
cord-022594-fx044gcd	1188	11	with	with	IN
cord-022594-fx044gcd	1188	12	ADEM	ADEM	NNP
cord-022594-fx044gcd	1188	13	,	,	,
cord-022594-fx044gcd	1188	14	such	such	JJ
cord-022594-fx044gcd	1188	15	as	as	IN
cord-022594-fx044gcd	1188	16	virus	virus	NN
cord-022594-fx044gcd	1188	17	infections	infection	NNS
cord-022594-fx044gcd	1188	18	(	(	-LRB-
cord-022594-fx044gcd	1188	19	including	include	VBG
cord-022594-fx044gcd	1188	20	rubella	rubella	NN
cord-022594-fx044gcd	1188	21	,	,	,
cord-022594-fx044gcd	1188	22	mumps	mumps	NN
cord-022594-fx044gcd	1188	23	,	,	,
cord-022594-fx044gcd	1188	24	VZV	VZV	NNP
cord-022594-fx044gcd	1188	25	,	,	,
cord-022594-fx044gcd	1188	26	EBV	EBV	NNP
cord-022594-fx044gcd	1188	27	,	,	,
cord-022594-fx044gcd	1188	28	CMV	CMV	NNP
cord-022594-fx044gcd	1188	29	,	,	,
cord-022594-fx044gcd	1188	30	influenza	influenza	NN
cord-022594-fx044gcd	1188	31	,	,	,
cord-022594-fx044gcd	1188	32	coxsackievirus	coxsackievirus	NNP
cord-022594-fx044gcd	1188	33	,	,	,
cord-022594-fx044gcd	1188	34	and	and	CC
cord-022594-fx044gcd	1188	35	hepatitis	hepatitis	NNP
cord-022594-fx044gcd	1188	36	C	C	NNP
cord-022594-fx044gcd	1188	37	)	)	-RRB-
cord-022594-fx044gcd	1188	38	and	and	CC
cord-022594-fx044gcd	1188	39	infection	infection	NN
cord-022594-fx044gcd	1188	40	with	with	IN
cord-022594-fx044gcd	1188	41	Mycoplasma	Mycoplasma	NNP
cord-022594-fx044gcd	1188	42	,	,	,
cord-022594-fx044gcd	1188	43	Borrelia	Borrelia	NNP
cord-022594-fx044gcd	1188	44	burgdorferi	burgdorferi	NN
cord-022594-fx044gcd	1188	45	,	,	,
cord-022594-fx044gcd	1188	46	and	and	CC
cord-022594-fx044gcd	1188	47	Leptospira	Leptospira	NNP
cord-022594-fx044gcd	1188	48	.	.	.
cord-022594-fx044gcd	1189	1	Measles	measles	NN
cord-022594-fx044gcd	1189	2	carries	carry	VBZ
cord-022594-fx044gcd	1189	3	the	the	DT
cord-022594-fx044gcd	1189	4	highest	high	JJS
cord-022594-fx044gcd	1189	5	risk	risk	NN
cord-022594-fx044gcd	1189	6	for	for	IN
cord-022594-fx044gcd	1189	7	ADEM	ADEM	NNP
cord-022594-fx044gcd	1189	8	of	of	IN
cord-022594-fx044gcd	1189	9	any	any	DT
cord-022594-fx044gcd	1189	10	infection	infection	NN
cord-022594-fx044gcd	1189	11	,	,	,
cord-022594-fx044gcd	1189	12	occurring	occur	VBG
cord-022594-fx044gcd	1189	13	in	in	IN
cord-022594-fx044gcd	1189	14	1	1	CD
cord-022594-fx044gcd	1189	15	per	per	IN
cord-022594-fx044gcd	1189	16	400	400	CD
cord-022594-fx044gcd	1189	17	to	to	TO
cord-022594-fx044gcd	1189	18	1	1	CD
cord-022594-fx044gcd	1189	19	per	per	IN
cord-022594-fx044gcd	1189	20	1000	1000	CD
cord-022594-fx044gcd	1189	21	cases	case	NNS
cord-022594-fx044gcd	1189	22	.	.	.
cord-022594-fx044gcd	1190	1	Although	although	IN
cord-022594-fx044gcd	1190	2	ADEM	ADEM	NNP
cord-022594-fx044gcd	1190	3	has	have	VBZ
cord-022594-fx044gcd	1190	4	been	be	VBN
cord-022594-fx044gcd	1190	5	reported	report	VBN
cord-022594-fx044gcd	1190	6	in	in	IN
cord-022594-fx044gcd	1190	7	association	association	NN
cord-022594-fx044gcd	1190	8	with	with	IN
cord-022594-fx044gcd	1190	9	measles	measles	NNP
cord-022594-fx044gcd	1190	10	immunization	immunization	NN
cord-022594-fx044gcd	1190	11	,	,	,
cord-022594-fx044gcd	1190	12	the	the	DT
cord-022594-fx044gcd	1190	13	risk	risk	NN
cord-022594-fx044gcd	1190	14	is	be	VBZ
cord-022594-fx044gcd	1190	15	far	far	RB
cord-022594-fx044gcd	1190	16	lower	low	JJR
cord-022594-fx044gcd	1190	17	than	than	IN
cord-022594-fx044gcd	1190	18	the	the	DT
cord-022594-fx044gcd	1190	19	risk	risk	NN
cord-022594-fx044gcd	1190	20	of	of	IN
cord-022594-fx044gcd	1190	21	acquiring	acquire	VBG
cord-022594-fx044gcd	1190	22	measles	measle	NNS
cord-022594-fx044gcd	1190	23	and	and	CC
cord-022594-fx044gcd	1190	24	its	-PRON-	PRP$
cord-022594-fx044gcd	1190	25	neurological	neurological	JJ
cord-022594-fx044gcd	1190	26	complications	complication	NNS
cord-022594-fx044gcd	1190	27	.	.	.
cord-022594-fx044gcd	1191	1	CLINICAL	clinical	JJ
cord-022594-fx044gcd	1191	2	FEATURES	features	NN
cord-022594-fx044gcd	1191	3	AND	and	CC
cord-022594-fx044gcd	1191	4	ASSOCIATED	ASSOCIATED	NNP
cord-022594-fx044gcd	1191	5	DISOR	DISOR	NNP
cord-022594-fx044gcd	1191	6	-	-	HYPH
cord-022594-fx044gcd	1191	7	DERS	DERS	NNP
cord-022594-fx044gcd	1191	8	.	.	.
cord-022594-fx044gcd	1192	1	A	a	DT
cord-022594-fx044gcd	1192	2	prodrome	prodrome	NN
cord-022594-fx044gcd	1192	3	of	of	IN
cord-022594-fx044gcd	1192	4	headache	headache	NN
cord-022594-fx044gcd	1192	5	,	,	,
cord-022594-fx044gcd	1192	6	low	low	JJ
cord-022594-fx044gcd	1192	7	-	-	HYPH
cord-022594-fx044gcd	1192	8	grade	grade	NN
cord-022594-fx044gcd	1192	9	fever	fever	NN
cord-022594-fx044gcd	1192	10	,	,	,
cord-022594-fx044gcd	1192	11	myalgias	myalgias	NNP
cord-022594-fx044gcd	1192	12	,	,	,
cord-022594-fx044gcd	1192	13	and	and	CC
cord-022594-fx044gcd	1192	14	malaise	malaise	NN
cord-022594-fx044gcd	1192	15	often	often	RB
cord-022594-fx044gcd	1192	16	precedes	precede	VBZ
cord-022594-fx044gcd	1192	17	the	the	DT
cord-022594-fx044gcd	1192	18	onset	onset	NN
cord-022594-fx044gcd	1192	19	of	of	IN
cord-022594-fx044gcd	1192	20	ADEM	ADEM	NNP
cord-022594-fx044gcd	1192	21	by	by	IN
cord-022594-fx044gcd	1192	22	a	a	DT
cord-022594-fx044gcd	1192	23	few	few	JJ
cord-022594-fx044gcd	1192	24	days	day	NNS
cord-022594-fx044gcd	1192	25	.	.	.
cord-022594-fx044gcd	1193	1	In	in	IN
cord-022594-fx044gcd	1193	2	a	a	DT
cord-022594-fx044gcd	1193	3	German	german	JJ
cord-022594-fx044gcd	1193	4	study	study	NN
cord-022594-fx044gcd	1193	5	of	of	IN
cord-022594-fx044gcd	1193	6	40	40	CD
cord-022594-fx044gcd	1193	7	cases	case	NNS
cord-022594-fx044gcd	1193	8	,	,	,
cord-022594-fx044gcd	1193	9	122	122	CD
cord-022594-fx044gcd	1193	10	the	the	DT
cord-022594-fx044gcd	1193	11	most	most	RBS
cord-022594-fx044gcd	1193	12	frequent	frequent	JJ
cord-022594-fx044gcd	1193	13	clinical	clinical	JJ
cord-022594-fx044gcd	1193	14	signs	sign	NNS
cord-022594-fx044gcd	1193	15	were	be	VBD
cord-022594-fx044gcd	1193	16	motor	motor	NN
cord-022594-fx044gcd	1193	17	deficit	deficit	NN
cord-022594-fx044gcd	1193	18	(	(	-LRB-
cord-022594-fx044gcd	1193	19	80	80	CD
cord-022594-fx044gcd	1193	20	%	%	NN
cord-022594-fx044gcd	1193	21	)	)	-RRB-
cord-022594-fx044gcd	1193	22	,	,	,
cord-022594-fx044gcd	1193	23	followed	follow	VBN
cord-022594-fx044gcd	1193	24	by	by	IN
cord-022594-fx044gcd	1193	25	sensory	sensory	JJ
cord-022594-fx044gcd	1193	26	deficits	deficit	NNS
cord-022594-fx044gcd	1193	27	,	,	,
cord-022594-fx044gcd	1193	28	brain	brain	NN
cord-022594-fx044gcd	1193	29	stem	stem	NN
cord-022594-fx044gcd	1193	30	signs	sign	NNS
cord-022594-fx044gcd	1193	31	,	,	,
cord-022594-fx044gcd	1193	32	and	and	CC
cord-022594-fx044gcd	1193	33	cerebellar	cerebellar	JJ
cord-022594-fx044gcd	1193	34	signs	sign	NNS
cord-022594-fx044gcd	1193	35	.	.	.
cord-022594-fx044gcd	1194	1	CSF	CSF	NNP
cord-022594-fx044gcd	1194	2	findings	finding	NNS
cord-022594-fx044gcd	1194	3	were	be	VBD
cord-022594-fx044gcd	1194	4	variable	variable	JJ
cord-022594-fx044gcd	1194	5	;	;	:
cord-022594-fx044gcd	1194	6	normal	normal	JJ
cord-022594-fx044gcd	1194	7	results	result	NNS
cord-022594-fx044gcd	1194	8	were	be	VBD
cord-022594-fx044gcd	1194	9	present	present	JJ
cord-022594-fx044gcd	1194	10	in	in	IN
cord-022594-fx044gcd	1194	11	up	up	IN
cord-022594-fx044gcd	1194	12	to	to	TO
cord-022594-fx044gcd	1194	13	20	20	CD
cord-022594-fx044gcd	1194	14	%	%	NN
cord-022594-fx044gcd	1194	15	of	of	IN
cord-022594-fx044gcd	1194	16	patients	patient	NNS
cord-022594-fx044gcd	1194	17	.	.	.
cord-022594-fx044gcd	1195	1	Oligoclonal	oligoclonal	JJ
cord-022594-fx044gcd	1195	2	bands	band	NNS
cord-022594-fx044gcd	1195	3	were	be	VBD
cord-022594-fx044gcd	1195	4	positive	positive	JJ
cord-022594-fx044gcd	1195	5	in	in	IN
cord-022594-fx044gcd	1195	6	over	over	IN
cord-022594-fx044gcd	1195	7	60	60	CD
cord-022594-fx044gcd	1195	8	%	%	NN
cord-022594-fx044gcd	1195	9	.	.	.
cord-022594-fx044gcd	1196	1	Almost	almost	RB
cord-022594-fx044gcd	1196	2	all	all	DT
cord-022594-fx044gcd	1196	3	patients	patient	NNS
cord-022594-fx044gcd	1196	4	improved	improve	VBD
cord-022594-fx044gcd	1196	5	during	during	IN
cord-022594-fx044gcd	1196	6	the	the	DT
cord-022594-fx044gcd	1196	7	acute	acute	JJ
cord-022594-fx044gcd	1196	8	phase	phase	NN
cord-022594-fx044gcd	1196	9	of	of	IN
cord-022594-fx044gcd	1196	10	the	the	DT
cord-022594-fx044gcd	1196	11	disease	disease	NN
cord-022594-fx044gcd	1196	12	.	.	.
cord-022594-fx044gcd	1197	1	Of	of	IN
cord-022594-fx044gcd	1197	2	the	the	DT
cord-022594-fx044gcd	1197	3	26	26	CD
cord-022594-fx044gcd	1197	4	patients	patient	NNS
cord-022594-fx044gcd	1197	5	with	with	IN
cord-022594-fx044gcd	1197	6	the	the	DT
cord-022594-fx044gcd	1197	7	final	final	JJ
cord-022594-fx044gcd	1197	8	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1197	9	of	of	IN
cord-022594-fx044gcd	1197	10	ADEM	ADEM	NNP
cord-022594-fx044gcd	1197	11	,	,	,
cord-022594-fx044gcd	1197	12	21	21	CD
cord-022594-fx044gcd	1197	13	had	have	VBD
cord-022594-fx044gcd	1197	14	minor	minor	JJ
cord-022594-fx044gcd	1197	15	or	or	CC
cord-022594-fx044gcd	1197	16	no	no	DT
cord-022594-fx044gcd	1197	17	symptoms	symptom	NNS
cord-022594-fx044gcd	1197	18	,	,	,
cord-022594-fx044gcd	1197	19	2	2	CD
cord-022594-fx044gcd	1197	20	died	die	VBD
cord-022594-fx044gcd	1197	21	,	,	,
cord-022594-fx044gcd	1197	22	the	the	DT
cord-022594-fx044gcd	1197	23	rest	rest	NN
cord-022594-fx044gcd	1197	24	had	have	VBD
cord-022594-fx044gcd	1197	25	moderate	moderate	JJ
cord-022594-fx044gcd	1197	26	symptoms	symptom	NNS
cord-022594-fx044gcd	1197	27	.	.	.
cord-022594-fx044gcd	1198	1	Compared	compare	VBN
cord-022594-fx044gcd	1198	2	to	to	IN
cord-022594-fx044gcd	1198	3	MS	MS	NNP
cord-022594-fx044gcd	1198	4	patients	patient	NNS
cord-022594-fx044gcd	1198	5	,	,	,
cord-022594-fx044gcd	1198	6	the	the	DT
cord-022594-fx044gcd	1198	7	ADEM	ADEM	NNP
cord-022594-fx044gcd	1198	8	patients	patient	NNS
cord-022594-fx044gcd	1198	9	were	be	VBD
cord-022594-fx044gcd	1198	10	older	old	JJR
cord-022594-fx044gcd	1198	11	,	,	,
cord-022594-fx044gcd	1198	12	and	and	CC
cord-022594-fx044gcd	1198	13	more	more	RBR
cord-022594-fx044gcd	1198	14	often	often	RB
cord-022594-fx044gcd	1198	15	had	have	VBD
cord-022594-fx044gcd	1198	16	a	a	DT
cord-022594-fx044gcd	1198	17	preceding	precede	VBG
cord-022594-fx044gcd	1198	18	infection	infection	NN
cord-022594-fx044gcd	1198	19	,	,	,
cord-022594-fx044gcd	1198	20	clinical	clinical	JJ
cord-022594-fx044gcd	1198	21	signs	sign	NNS
cord-022594-fx044gcd	1198	22	of	of	IN
cord-022594-fx044gcd	1198	23	brain	brain	NN
cord-022594-fx044gcd	1198	24	stem	stem	NN
cord-022594-fx044gcd	1198	25	involvement	involvement	NN
cord-022594-fx044gcd	1198	26	,	,	,
cord-022594-fx044gcd	1198	27	a	a	DT
cord-022594-fx044gcd	1198	28	higher	high	JJR
cord-022594-fx044gcd	1198	29	CSF	CSF	NNP
cord-022594-fx044gcd	1198	30	albumin	albumin	NN
cord-022594-fx044gcd	1198	31	fraction	fraction	NN
cord-022594-fx044gcd	1198	32	,	,	,
cord-022594-fx044gcd	1198	33	and	and	CC
cord-022594-fx044gcd	1198	34	infratentorial	infratentorial	JJ
cord-022594-fx044gcd	1198	35	lesions	lesion	NNS
cord-022594-fx044gcd	1198	36	.	.	.
cord-022594-fx044gcd	1199	1	Neurological	neurological	JJ
cord-022594-fx044gcd	1199	2	symptoms	symptom	NNS
cord-022594-fx044gcd	1199	3	develop	develop	VBP
cord-022594-fx044gcd	1199	4	rapidly	rapidly	RB
cord-022594-fx044gcd	1199	5	in	in	IN
cord-022594-fx044gcd	1199	6	the	the	DT
cord-022594-fx044gcd	1199	7	acute	acute	JJ
cord-022594-fx044gcd	1199	8	phase	phase	NN
cord-022594-fx044gcd	1199	9	and	and	CC
cord-022594-fx044gcd	1199	10	are	be	VBP
cord-022594-fx044gcd	1199	11	commonly	commonly	RB
cord-022594-fx044gcd	1199	12	associated	associate	VBN
cord-022594-fx044gcd	1199	13	with	with	IN
cord-022594-fx044gcd	1199	14	encephalopathy	encephalopathy	NN
cord-022594-fx044gcd	1199	15	,	,	,
cord-022594-fx044gcd	1199	16	stupor	stupor	NN
cord-022594-fx044gcd	1199	17	,	,	,
cord-022594-fx044gcd	1199	18	coma	coma	NN
cord-022594-fx044gcd	1199	19	,	,	,
cord-022594-fx044gcd	1199	20	meningismus	meningismus	NNP
cord-022594-fx044gcd	1199	21	,	,	,
cord-022594-fx044gcd	1199	22	and	and	CC
cord-022594-fx044gcd	1199	23	seizures	seizure	NNS
cord-022594-fx044gcd	1199	24	.	.	.
cord-022594-fx044gcd	1200	1	Peak	peak	NN
cord-022594-fx044gcd	1200	2	severity	severity	NN
cord-022594-fx044gcd	1200	3	occurs	occur	VBZ
cord-022594-fx044gcd	1200	4	within	within	IN
cord-022594-fx044gcd	1200	5	several	several	JJ
cord-022594-fx044gcd	1200	6	days	day	NNS
cord-022594-fx044gcd	1200	7	,	,	,
cord-022594-fx044gcd	1200	8	and	and	CC
cord-022594-fx044gcd	1200	9	recovery	recovery	NN
cord-022594-fx044gcd	1200	10	may	may	MD
cord-022594-fx044gcd	1200	11	begin	begin	VB
cord-022594-fx044gcd	1200	12	soon	soon	RB
cord-022594-fx044gcd	1200	13	afterward	afterward	RB
cord-022594-fx044gcd	1200	14	.	.	.
cord-022594-fx044gcd	1201	1	Occasionally	occasionally	RB
cord-022594-fx044gcd	1201	2	,	,	,
cord-022594-fx044gcd	1201	3	ADEM	ADEM	NNP
cord-022594-fx044gcd	1201	4	may	may	MD
cord-022594-fx044gcd	1201	5	evolve	evolve	VB
cord-022594-fx044gcd	1201	6	over	over	IN
cord-022594-fx044gcd	1201	7	a	a	DT
cord-022594-fx044gcd	1201	8	few	few	JJ
cord-022594-fx044gcd	1201	9	months	month	NNS
cord-022594-fx044gcd	1201	10	and	and	CC
cord-022594-fx044gcd	1201	11	there	there	EX
cord-022594-fx044gcd	1201	12	may	may	MD
cord-022594-fx044gcd	1201	13	be	be	VB
cord-022594-fx044gcd	1201	14	a	a	DT
cord-022594-fx044gcd	1201	15	second	second	JJ
cord-022594-fx044gcd	1201	16	clinical	clinical	JJ
cord-022594-fx044gcd	1201	17	deterioration	deterioration	NN
cord-022594-fx044gcd	1201	18	or	or	CC
cord-022594-fx044gcd	1201	19	subacute	subacute	JJ
cord-022594-fx044gcd	1201	20	progression	progression	NN
cord-022594-fx044gcd	1201	21	for	for	IN
cord-022594-fx044gcd	1201	22	a	a	DT
cord-022594-fx044gcd	1201	23	time	time	NN
cord-022594-fx044gcd	1201	24	.	.	.
cord-022594-fx044gcd	1202	1	In	in	IN
cord-022594-fx044gcd	1202	2	these	these	DT
cord-022594-fx044gcd	1202	3	unusual	unusual	JJ
cord-022594-fx044gcd	1202	4	cases	case	NNS
cord-022594-fx044gcd	1202	5	,	,	,
cord-022594-fx044gcd	1202	6	the	the	DT
cord-022594-fx044gcd	1202	7	distinction	distinction	NN
cord-022594-fx044gcd	1202	8	from	from	IN
cord-022594-fx044gcd	1202	9	MS	MS	NNP
cord-022594-fx044gcd	1202	10	is	be	VBZ
cord-022594-fx044gcd	1202	11	difficult	difficult	JJ
cord-022594-fx044gcd	1202	12	.	.	.
cord-022594-fx044gcd	1203	1	Three	three	CD
cord-022594-fx044gcd	1203	2	recent	recent	JJ
cord-022594-fx044gcd	1203	3	large	large	JJ
cord-022594-fx044gcd	1203	4	retrospective	retrospective	JJ
cord-022594-fx044gcd	1203	5	series	series	NN
cord-022594-fx044gcd	1203	6	and	and	CC
cord-022594-fx044gcd	1203	7	an	an	DT
cord-022594-fx044gcd	1203	8	accompanying	accompany	VBG
cord-022594-fx044gcd	1203	9	editorial	editorial	NN
cord-022594-fx044gcd	1203	10	have	have	VBP
cord-022594-fx044gcd	1203	11	highlighted	highlight	VBN
cord-022594-fx044gcd	1203	12	that	that	IN
cord-022594-fx044gcd	1203	13	there	there	EX
cord-022594-fx044gcd	1203	14	remain	remain	VBP
cord-022594-fx044gcd	1203	15	no	no	DT
cord-022594-fx044gcd	1203	16	clinical	clinical	JJ
cord-022594-fx044gcd	1203	17	or	or	CC
cord-022594-fx044gcd	1203	18	laboratory	laboratory	NN
cord-022594-fx044gcd	1203	19	features	feature	NNS
cord-022594-fx044gcd	1203	20	that	that	WDT
cord-022594-fx044gcd	1203	21	accurately	accurately	RB
cord-022594-fx044gcd	1203	22	allow	allow	VBP
cord-022594-fx044gcd	1203	23	one	one	CD
cord-022594-fx044gcd	1203	24	to	to	TO
cord-022594-fx044gcd	1203	25	predict	predict	VB
cord-022594-fx044gcd	1203	26	which	which	WDT
cord-022594-fx044gcd	1203	27	adult	adult	NN
cord-022594-fx044gcd	1203	28	or	or	CC
cord-022594-fx044gcd	1203	29	pediatric	pediatric	JJ
cord-022594-fx044gcd	1203	30	ADEM	ADEM	NNP
cord-022594-fx044gcd	1203	31	patients	patient	NNS
cord-022594-fx044gcd	1203	32	will	will	MD
cord-022594-fx044gcd	1203	33	develop	develop	VB
cord-022594-fx044gcd	1203	34	.	.	.
cord-022594-fx044gcd	1204	1	[	[	-LRB-
cord-022594-fx044gcd	1204	2	122	122	CD
cord-022594-fx044gcd	1204	3	]	]	-RRB-
cord-022594-fx044gcd	1204	4	[	[	-LRB-
cord-022594-fx044gcd	1204	5	123	123	CD
cord-022594-fx044gcd	1204	6	]	]	-RRB-
cord-022594-fx044gcd	1204	7	[	[	-LRB-
cord-022594-fx044gcd	1204	8	124	124	CD
cord-022594-fx044gcd	1204	9	]	]	-RRB-
cord-022594-fx044gcd	1205	1	[	[	-LRB-
cord-022594-fx044gcd	1205	2	125	125	CD
cord-022594-fx044gcd	1205	3	]	]	-RRB-
cord-022594-fx044gcd	1205	4	DIFFERENTIAL	differential	NN
cord-022594-fx044gcd	1205	5	DIAGNOSIS	diagnosis	NN
cord-022594-fx044gcd	1205	6	.	.	.
cord-022594-fx044gcd	1206	1	One	one	CD
cord-022594-fx044gcd	1206	2	of	of	IN
cord-022594-fx044gcd	1206	3	the	the	DT
cord-022594-fx044gcd	1206	4	primary	primary	JJ
cord-022594-fx044gcd	1206	5	concerns	concern	NNS
cord-022594-fx044gcd	1206	6	after	after	IN
cord-022594-fx044gcd	1206	7	a	a	DT
cord-022594-fx044gcd	1206	8	single	single	JJ
cord-022594-fx044gcd	1206	9	demyelinating	demyelinating	NN
cord-022594-fx044gcd	1206	10	episode	episode	NN
cord-022594-fx044gcd	1206	11	is	be	VBZ
cord-022594-fx044gcd	1206	12	whether	whether	IN
cord-022594-fx044gcd	1206	13	other	other	JJ
cord-022594-fx044gcd	1206	14	bouts	bout	NNS
cord-022594-fx044gcd	1206	15	can	can	MD
cord-022594-fx044gcd	1206	16	be	be	VB
cord-022594-fx044gcd	1206	17	expected	expect	VBN
cord-022594-fx044gcd	1206	18	(	(	-LRB-
cord-022594-fx044gcd	1206	19	e.g.	e.g.	RB
cord-022594-fx044gcd	1206	20	,	,	,
cord-022594-fx044gcd	1206	21	MS	MS	NNP
cord-022594-fx044gcd	1206	22	)	)	-RRB-
cord-022594-fx044gcd	1206	23	.	.	.
cord-022594-fx044gcd	1207	1	Several	several	JJ
cord-022594-fx044gcd	1207	2	features	feature	NNS
cord-022594-fx044gcd	1207	3	may	may	MD
cord-022594-fx044gcd	1207	4	tip	tip	VB
cord-022594-fx044gcd	1207	5	the	the	DT
cord-022594-fx044gcd	1207	6	balance	balance	NN
cord-022594-fx044gcd	1207	7	toward	toward	IN
cord-022594-fx044gcd	1207	8	one	one	CD
cord-022594-fx044gcd	1207	9	or	or	CC
cord-022594-fx044gcd	1207	10	the	the	DT
cord-022594-fx044gcd	1207	11	other	other	JJ
cord-022594-fx044gcd	1207	12	,	,	,
cord-022594-fx044gcd	1207	13	but	but	CC
cord-022594-fx044gcd	1207	14	the	the	DT
cord-022594-fx044gcd	1207	15	proper	proper	JJ
cord-022594-fx044gcd	1207	16	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1207	17	becomes	become	VBZ
cord-022594-fx044gcd	1207	18	apparent	apparent	JJ
cord-022594-fx044gcd	1207	19	only	only	RB
cord-022594-fx044gcd	1207	20	with	with	IN
cord-022594-fx044gcd	1207	21	time	time	NN
cord-022594-fx044gcd	1207	22	.	.	.
cord-022594-fx044gcd	1208	1	Classically	classically	RB
cord-022594-fx044gcd	1208	2	,	,	,
cord-022594-fx044gcd	1208	3	ADEM	ADEM	NNP
cord-022594-fx044gcd	1208	4	is	be	VBZ
cord-022594-fx044gcd	1208	5	characterized	characterize	VBN
cord-022594-fx044gcd	1208	6	by	by	IN
cord-022594-fx044gcd	1208	7	the	the	DT
cord-022594-fx044gcd	1208	8	multifocal	multifocal	JJ
cord-022594-fx044gcd	1208	9	involvement	involvement	NN
cord-022594-fx044gcd	1208	10	at	at	IN
cord-022594-fx044gcd	1208	11	onset	onset	NN
cord-022594-fx044gcd	1208	12	whereas	whereas	IN
cord-022594-fx044gcd	1208	13	MS	MS	NNP
cord-022594-fx044gcd	1208	14	often	often	RB
cord-022594-fx044gcd	1208	15	presents	present	VBZ
cord-022594-fx044gcd	1208	16	with	with	IN
cord-022594-fx044gcd	1208	17	monosymptomatic	monosymptomatic	JJ
cord-022594-fx044gcd	1208	18	deficits	deficit	NNS
cord-022594-fx044gcd	1208	19	such	such	JJ
cord-022594-fx044gcd	1208	20	as	as	IN
cord-022594-fx044gcd	1208	21	ON	ON	NNP
cord-022594-fx044gcd	1208	22	.	.	.
cord-022594-fx044gcd	1209	1	However	however	RB
cord-022594-fx044gcd	1209	2	,	,	,
cord-022594-fx044gcd	1209	3	ADEM	ADEM	NNP
cord-022594-fx044gcd	1209	4	may	may	MD
cord-022594-fx044gcd	1209	5	cause	cause	VB
cord-022594-fx044gcd	1209	6	unifocal	unifocal	JJ
cord-022594-fx044gcd	1209	7	symptoms	symptom	NNS
cord-022594-fx044gcd	1209	8	and	and	CC
cord-022594-fx044gcd	1209	9	MS	MS	NNP
cord-022594-fx044gcd	1209	10	may	may	MD
cord-022594-fx044gcd	1209	11	present	present	VB
cord-022594-fx044gcd	1209	12	with	with	IN
cord-022594-fx044gcd	1209	13	multifocal	multifocal	JJ
cord-022594-fx044gcd	1209	14	CNS	CNS	NNP
cord-022594-fx044gcd	1209	15	involvement	involvement	NN
cord-022594-fx044gcd	1209	16	,	,	,
cord-022594-fx044gcd	1209	17	especially	especially	RB
cord-022594-fx044gcd	1209	18	in	in	IN
cord-022594-fx044gcd	1209	19	children	child	NNS
cord-022594-fx044gcd	1209	20	.	.	.
cord-022594-fx044gcd	1210	1	The	the	DT
cord-022594-fx044gcd	1210	2	monosymptomatic	monosymptomatic	JJ
cord-022594-fx044gcd	1210	3	deficits	deficit	NNS
cord-022594-fx044gcd	1210	4	caused	cause	VBN
cord-022594-fx044gcd	1210	5	by	by	IN
cord-022594-fx044gcd	1210	6	ADEM	ADEM	NNP
cord-022594-fx044gcd	1210	7	are	be	VBP
cord-022594-fx044gcd	1210	8	more	more	RBR
cord-022594-fx044gcd	1210	9	commonly	commonly	RB
cord-022594-fx044gcd	1210	10	severe	severe	JJ
cord-022594-fx044gcd	1210	11	,	,	,
cord-022594-fx044gcd	1210	12	such	such	JJ
cord-022594-fx044gcd	1210	13	as	as	IN
cord-022594-fx044gcd	1210	14	bilateral	bilateral	JJ
cord-022594-fx044gcd	1210	15	ON	on	NN
cord-022594-fx044gcd	1210	16	and	and	CC
cord-022594-fx044gcd	1210	17	complete	complete	JJ
cord-022594-fx044gcd	1210	18	transverse	transverse	JJ
cord-022594-fx044gcd	1210	19	myelitis	myelitis	NN
cord-022594-fx044gcd	1210	20	.	.	.
cord-022594-fx044gcd	1211	1	Although	although	IN
cord-022594-fx044gcd	1211	2	OCBs	ocb	NNS
cord-022594-fx044gcd	1211	3	occur	occur	VBP
cord-022594-fx044gcd	1211	4	transiently	transiently	RB
cord-022594-fx044gcd	1211	5	in	in	IN
cord-022594-fx044gcd	1211	6	about	about	RB
cord-022594-fx044gcd	1211	7	one	one	CD
cord-022594-fx044gcd	1211	8	third	third	NN
cord-022594-fx044gcd	1211	9	of	of	IN
cord-022594-fx044gcd	1211	10	ADEM	ADEM	NNP
cord-022594-fx044gcd	1211	11	cases	case	NNS
cord-022594-fx044gcd	1211	12	,	,	,
cord-022594-fx044gcd	1211	13	their	-PRON-	PRP$
cord-022594-fx044gcd	1211	14	persistence	persistence	NN
cord-022594-fx044gcd	1211	15	implies	imply	VBZ
cord-022594-fx044gcd	1211	16	a	a	DT
cord-022594-fx044gcd	1211	17	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1211	18	of	of	IN
cord-022594-fx044gcd	1211	19	MS	MS	NNP
cord-022594-fx044gcd	1211	20	.	.	.
cord-022594-fx044gcd	1212	1	The	the	DT
cord-022594-fx044gcd	1212	2	subsequent	subsequent	JJ
cord-022594-fx044gcd	1212	3	disappearance	disappearance	NN
cord-022594-fx044gcd	1212	4	of	of	IN
cord-022594-fx044gcd	1212	5	OCBs	OCBs	NNP
cord-022594-fx044gcd	1212	6	,	,	,
cord-022594-fx044gcd	1212	7	when	when	WRB
cord-022594-fx044gcd	1212	8	performed	perform	VBN
cord-022594-fx044gcd	1212	9	by	by	IN
cord-022594-fx044gcd	1212	10	consistent	consistent	JJ
cord-022594-fx044gcd	1212	11	techniques	technique	NNS
cord-022594-fx044gcd	1212	12	,	,	,
cord-022594-fx044gcd	1212	13	is	be	VBZ
cord-022594-fx044gcd	1212	14	evidence	evidence	NN
cord-022594-fx044gcd	1212	15	against	against	IN
cord-022594-fx044gcd	1212	16	MS	MS	NNP
cord-022594-fx044gcd	1212	17	.	.	.
cord-022594-fx044gcd	1213	1	The	the	DT
cord-022594-fx044gcd	1213	2	MRI	MRI	NNP
cord-022594-fx044gcd	1213	3	appearance	appearance	NN
cord-022594-fx044gcd	1213	4	of	of	IN
cord-022594-fx044gcd	1213	5	these	these	DT
cord-022594-fx044gcd	1213	6	two	two	CD
cord-022594-fx044gcd	1213	7	disorders	disorder	NNS
cord-022594-fx044gcd	1213	8	is	be	VBZ
cord-022594-fx044gcd	1213	9	often	often	RB
cord-022594-fx044gcd	1213	10	identical	identical	JJ
cord-022594-fx044gcd	1213	11	,	,	,
cord-022594-fx044gcd	1213	12	125	125	CD
cord-022594-fx044gcd	1213	13	but	but	CC
cord-022594-fx044gcd	1213	14	the	the	DT
cord-022594-fx044gcd	1213	15	presence	presence	NN
cord-022594-fx044gcd	1213	16	of	of	IN
cord-022594-fx044gcd	1213	17	basal	basal	NN
cord-022594-fx044gcd	1213	18	ganglia	ganglion	NNS
cord-022594-fx044gcd	1213	19	or	or	CC
cord-022594-fx044gcd	1213	20	cortical	cortical	JJ
cord-022594-fx044gcd	1213	21	lesions	lesion	NNS
cord-022594-fx044gcd	1213	22	,	,	,
cord-022594-fx044gcd	1213	23	or	or	CC
cord-022594-fx044gcd	1213	24	large	large	JJ
cord-022594-fx044gcd	1213	25	globular	globular	JJ
cord-022594-fx044gcd	1213	26	white	white	JJ
cord-022594-fx044gcd	1213	27	matter	matter	NN
cord-022594-fx044gcd	1213	28	lesions	lesion	NNS
cord-022594-fx044gcd	1213	29	,	,	,
cord-022594-fx044gcd	1213	30	is	be	VBZ
cord-022594-fx044gcd	1213	31	more	more	RBR
cord-022594-fx044gcd	1213	32	frequent	frequent	JJ
cord-022594-fx044gcd	1213	33	in	in	IN
cord-022594-fx044gcd	1213	34	ADEM	ADEM	NNP
cord-022594-fx044gcd	1213	35	.	.	.
cord-022594-fx044gcd	1214	1	The	the	DT
cord-022594-fx044gcd	1214	2	fulminant	fulminant	JJ
cord-022594-fx044gcd	1214	3	development	development	NN
cord-022594-fx044gcd	1214	4	of	of	IN
cord-022594-fx044gcd	1214	5	ADEM	ADEM	NNP
cord-022594-fx044gcd	1214	6	is	be	VBZ
cord-022594-fx044gcd	1214	7	distinctive	distinctive	JJ
cord-022594-fx044gcd	1214	8	but	but	CC
cord-022594-fx044gcd	1214	9	not	not	RB
cord-022594-fx044gcd	1214	10	pathognomonic	pathognomonic	JJ
cord-022594-fx044gcd	1214	11	,	,	,
cord-022594-fx044gcd	1214	12	because	because	IN
cord-022594-fx044gcd	1214	13	a	a	DT
cord-022594-fx044gcd	1214	14	rare	rare	JJ
cord-022594-fx044gcd	1214	15	form	form	NN
cord-022594-fx044gcd	1214	16	of	of	IN
cord-022594-fx044gcd	1214	17	MS	MS	NNP
cord-022594-fx044gcd	1214	18	known	know	VBN
cord-022594-fx044gcd	1214	19	as	as	IN
cord-022594-fx044gcd	1214	20	Marburg	Marburg	NNP
cord-022594-fx044gcd	1214	21	's	's	POS
cord-022594-fx044gcd	1214	22	MS	MS	NNP
cord-022594-fx044gcd	1214	23	is	be	VBZ
cord-022594-fx044gcd	1214	24	also	also	RB
cord-022594-fx044gcd	1214	25	rapid	rapid	JJ
cord-022594-fx044gcd	1214	26	in	in	IN
cord-022594-fx044gcd	1214	27	onset	onset	NN
cord-022594-fx044gcd	1214	28	and	and	CC
cord-022594-fx044gcd	1214	29	often	often	RB
cord-022594-fx044gcd	1214	30	deadly	deadly	JJ
cord-022594-fx044gcd	1214	31	.	.	.
cord-022594-fx044gcd	1215	1	The	the	DT
cord-022594-fx044gcd	1215	2	appearance	appearance	NN
cord-022594-fx044gcd	1215	3	of	of	IN
cord-022594-fx044gcd	1215	4	brain	brain	NN
cord-022594-fx044gcd	1215	5	stem	stem	NN
cord-022594-fx044gcd	1215	6	,	,	,
cord-022594-fx044gcd	1215	7	periventricular	periventricular	NNP
cord-022594-fx044gcd	1215	8	,	,	,
cord-022594-fx044gcd	1215	9	and	and	CC
cord-022594-fx044gcd	1215	10	multiple	multiple	JJ
cord-022594-fx044gcd	1215	11	,	,	,
cord-022594-fx044gcd	1215	12	large	large	JJ
cord-022594-fx044gcd	1215	13	cerebral	cerebral	JJ
cord-022594-fx044gcd	1215	14	white	white	JJ
cord-022594-fx044gcd	1215	15	matter	matter	NN
cord-022594-fx044gcd	1215	16	lesions	lesion	NNS
cord-022594-fx044gcd	1215	17	and	and	CC
cord-022594-fx044gcd	1215	18	the	the	DT
cord-022594-fx044gcd	1215	19	presence	presence	NN
cord-022594-fx044gcd	1215	20	of	of	IN
cord-022594-fx044gcd	1215	21	OCBs	OCBs	NNP
cord-022594-fx044gcd	1215	22	may	may	MD
cord-022594-fx044gcd	1215	23	distinguish	distinguish	VB
cord-022594-fx044gcd	1215	24	Marburg	Marburg	NNP
cord-022594-fx044gcd	1215	25	's	's	POS
cord-022594-fx044gcd	1215	26	variant	variant	NN
cord-022594-fx044gcd	1215	27	from	from	IN
cord-022594-fx044gcd	1215	28	ADEM	ADEM	NNP
cord-022594-fx044gcd	1215	29	.	.	.
cord-022594-fx044gcd	1216	1	On	on	IN
cord-022594-fx044gcd	1216	2	rare	rare	JJ
cord-022594-fx044gcd	1216	3	occasions	occasion	NNS
cord-022594-fx044gcd	1216	4	,	,	,
cord-022594-fx044gcd	1216	5	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1216	6	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1216	7	lesions	lesion	NNS
cord-022594-fx044gcd	1216	8	may	may	MD
cord-022594-fx044gcd	1216	9	reach	reach	VB
cord-022594-fx044gcd	1216	10	a	a	DT
cord-022594-fx044gcd	1216	11	large	large	JJ
cord-022594-fx044gcd	1216	12	size	size	NN
cord-022594-fx044gcd	1216	13	and	and	CC
cord-022594-fx044gcd	1216	14	resemble	resemble	JJ
cord-022594-fx044gcd	1216	15	tumors	tumor	NNS
cord-022594-fx044gcd	1216	16	(	(	-LRB-
cord-022594-fx044gcd	1216	17	especially	especially	RB
cord-022594-fx044gcd	1216	18	lymphoma	lymphoma	NN
cord-022594-fx044gcd	1216	19	)	)	-RRB-
cord-022594-fx044gcd	1216	20	on	on	IN
cord-022594-fx044gcd	1216	21	MRI	MRI	NNP
cord-022594-fx044gcd	1216	22	,	,	,
cord-022594-fx044gcd	1216	23	necessitating	necessitate	VBG
cord-022594-fx044gcd	1216	24	biopsy	biopsy	NN
cord-022594-fx044gcd	1216	25	for	for	IN
cord-022594-fx044gcd	1216	26	clarification	clarification	NN
cord-022594-fx044gcd	1216	27	.	.	.
cord-022594-fx044gcd	1217	1	There	there	EX
cord-022594-fx044gcd	1217	2	is	be	VBZ
cord-022594-fx044gcd	1217	3	usually	usually	RB
cord-022594-fx044gcd	1217	4	one	one	CD
cord-022594-fx044gcd	1217	5	dominant	dominant	JJ
cord-022594-fx044gcd	1217	6	lesion	lesion	NN
cord-022594-fx044gcd	1217	7	,	,	,
cord-022594-fx044gcd	1217	8	but	but	CC
cord-022594-fx044gcd	1217	9	smaller	small	JJR
cord-022594-fx044gcd	1217	10	separate	separate	JJ
cord-022594-fx044gcd	1217	11	lesions	lesion	NNS
cord-022594-fx044gcd	1217	12	may	may	MD
cord-022594-fx044gcd	1217	13	be	be	VB
cord-022594-fx044gcd	1217	14	identifiable	identifiable	JJ
cord-022594-fx044gcd	1217	15	.	.	.
cord-022594-fx044gcd	1218	1	These	these	DT
cord-022594-fx044gcd	1218	2	have	have	VBP
cord-022594-fx044gcd	1218	3	been	be	VBN
cord-022594-fx044gcd	1218	4	referred	refer	VBN
cord-022594-fx044gcd	1218	5	to	to	IN
cord-022594-fx044gcd	1218	6	as	as	IN
cord-022594-fx044gcd	1218	7	both	both	CC
cord-022594-fx044gcd	1218	8	ADEM	ADEM	NNP
cord-022594-fx044gcd	1218	9	and	and	CC
cord-022594-fx044gcd	1218	10	MS	MS	NNP
cord-022594-fx044gcd	1218	11	in	in	IN
cord-022594-fx044gcd	1218	12	the	the	DT
cord-022594-fx044gcd	1218	13	literature	literature	NN
cord-022594-fx044gcd	1218	14	.	.	.
cord-022594-fx044gcd	1219	1	The	the	DT
cord-022594-fx044gcd	1219	2	prognosis	prognosis	NN
cord-022594-fx044gcd	1219	3	for	for	IN
cord-022594-fx044gcd	1219	4	recovery	recovery	NN
cord-022594-fx044gcd	1219	5	is	be	VBZ
cord-022594-fx044gcd	1219	6	often	often	RB
cord-022594-fx044gcd	1219	7	quite	quite	RB
cord-022594-fx044gcd	1219	8	good	good	JJ
cord-022594-fx044gcd	1219	9	,	,	,
cord-022594-fx044gcd	1219	10	although	although	IN
cord-022594-fx044gcd	1219	11	approximately	approximately	RB
cord-022594-fx044gcd	1219	12	one	one	CD
cord-022594-fx044gcd	1219	13	third	third	JJ
cord-022594-fx044gcd	1219	14	suffer	suffer	VB
cord-022594-fx044gcd	1219	15	subsequent	subsequent	JJ
cord-022594-fx044gcd	1219	16	attacks	attack	NNS
cord-022594-fx044gcd	1219	17	.	.	.
cord-022594-fx044gcd	1220	1	Some	some	DT
cord-022594-fx044gcd	1220	2	develop	develop	VBP
cord-022594-fx044gcd	1220	3	typical	typical	JJ
cord-022594-fx044gcd	1220	4	MS	MS	NNP
cord-022594-fx044gcd	1220	5	,	,	,
cord-022594-fx044gcd	1220	6	whereas	whereas	IN
cord-022594-fx044gcd	1220	7	others	other	NNS
cord-022594-fx044gcd	1220	8	have	have	VBP
cord-022594-fx044gcd	1220	9	recurring	recur	VBG
cord-022594-fx044gcd	1220	10	tumor	tumor	NN
cord-022594-fx044gcd	1220	11	-	-	HYPH
cord-022594-fx044gcd	1220	12	like	like	JJ
cord-022594-fx044gcd	1220	13	lesions	lesion	NNS
cord-022594-fx044gcd	1220	14	.	.	.
cord-022594-fx044gcd	1221	1	The	the	DT
cord-022594-fx044gcd	1221	2	term	term	NN
cord-022594-fx044gcd	1221	3	multiphasic	multiphasic	JJ
cord-022594-fx044gcd	1221	4	ADEM	ADEM	NNP
cord-022594-fx044gcd	1221	5	has	have	VBZ
cord-022594-fx044gcd	1221	6	been	be	VBN
cord-022594-fx044gcd	1221	7	used	use	VBN
cord-022594-fx044gcd	1221	8	when	when	WRB
cord-022594-fx044gcd	1221	9	patients	patient	NNS
cord-022594-fx044gcd	1221	10	have	have	VBP
cord-022594-fx044gcd	1221	11	large	large	JJ
cord-022594-fx044gcd	1221	12	recurrences	recurrence	NNS
cord-022594-fx044gcd	1221	13	in	in	IN
cord-022594-fx044gcd	1221	14	the	the	DT
cord-022594-fx044gcd	1221	15	same	same	JJ
cord-022594-fx044gcd	1221	16	location	location	NN
cord-022594-fx044gcd	1221	17	,	,	,
cord-022594-fx044gcd	1221	18	and	and	CC
cord-022594-fx044gcd	1221	19	relapsing	relapse	VBG
cord-022594-fx044gcd	1221	20	ADEM	ADEM	NNP
cord-022594-fx044gcd	1221	21	refers	refer	VBZ
cord-022594-fx044gcd	1221	22	to	to	IN
cord-022594-fx044gcd	1221	23	recurrences	recurrence	NNS
cord-022594-fx044gcd	1221	24	at	at	IN
cord-022594-fx044gcd	1221	25	different	different	JJ
cord-022594-fx044gcd	1221	26	sites	site	NNS
cord-022594-fx044gcd	1221	27	.	.	.
cord-022594-fx044gcd	1222	1	The	the	DT
cord-022594-fx044gcd	1222	2	relationship	relationship	NN
cord-022594-fx044gcd	1222	3	of	of	IN
cord-022594-fx044gcd	1222	4	these	these	DT
cord-022594-fx044gcd	1222	5	entities	entity	NNS
cord-022594-fx044gcd	1222	6	with	with	IN
cord-022594-fx044gcd	1222	7	MS	MS	NNP
cord-022594-fx044gcd	1222	8	is	be	VBZ
cord-022594-fx044gcd	1222	9	unclear	unclear	JJ
cord-022594-fx044gcd	1222	10	.	.	.
cord-022594-fx044gcd	1223	1	Balo	Balo	NNP
cord-022594-fx044gcd	1223	2	's	's	POS
cord-022594-fx044gcd	1223	3	concentric	concentric	JJ
cord-022594-fx044gcd	1223	4	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1223	5	refers	refer	VBZ
cord-022594-fx044gcd	1223	6	to	to	IN
cord-022594-fx044gcd	1223	7	the	the	DT
cord-022594-fx044gcd	1223	8	pathological	pathological	JJ
cord-022594-fx044gcd	1223	9	finding	finding	NN
cord-022594-fx044gcd	1223	10	of	of	IN
cord-022594-fx044gcd	1223	11	alternating	alternate	VBG
cord-022594-fx044gcd	1223	12	bands	band	NNS
cord-022594-fx044gcd	1223	13	of	of	IN
cord-022594-fx044gcd	1223	14	demyelination	demyelination	NN
cord-022594-fx044gcd	1223	15	and	and	CC
cord-022594-fx044gcd	1223	16	remyelination	remyelination	NN
cord-022594-fx044gcd	1223	17	.	.	.
cord-022594-fx044gcd	1224	1	These	these	DT
cord-022594-fx044gcd	1224	2	patients	patient	NNS
cord-022594-fx044gcd	1224	3	typically	typically	RB
cord-022594-fx044gcd	1224	4	have	have	VBP
cord-022594-fx044gcd	1224	5	large	large	JJ
cord-022594-fx044gcd	1224	6	lesions	lesion	NNS
cord-022594-fx044gcd	1224	7	and	and	CC
cord-022594-fx044gcd	1224	8	subacute	subacute	JJ
cord-022594-fx044gcd	1224	9	deficits	deficit	NNS
cord-022594-fx044gcd	1224	10	similar	similar	JJ
cord-022594-fx044gcd	1224	11	to	to	IN
cord-022594-fx044gcd	1224	12	those	those	DT
cord-022594-fx044gcd	1224	13	described	describe	VBN
cord-022594-fx044gcd	1224	14	earlier	early	RBR
cord-022594-fx044gcd	1224	15	.	.	.
cord-022594-fx044gcd	1225	1	Typical	typical	JJ
cord-022594-fx044gcd	1225	2	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1225	3	lesions	lesion	NNS
cord-022594-fx044gcd	1225	4	commonly	commonly	RB
cord-022594-fx044gcd	1225	5	coexist	coexist	VBP
cord-022594-fx044gcd	1225	6	,	,	,
cord-022594-fx044gcd	1225	7	and	and	CC
cord-022594-fx044gcd	1225	8	rarely	rarely	RB
cord-022594-fx044gcd	1225	9	CDMS	CDMS	NNP
cord-022594-fx044gcd	1225	10	patients	patient	NNS
cord-022594-fx044gcd	1225	11	are	be	VBP
cord-022594-fx044gcd	1225	12	noted	note	VBN
cord-022594-fx044gcd	1225	13	to	to	TO
cord-022594-fx044gcd	1225	14	have	have	VB
cord-022594-fx044gcd	1225	15	similar	similar	JJ
cord-022594-fx044gcd	1225	16	-	-	HYPH
cord-022594-fx044gcd	1225	17	appearing	appearing	JJ
cord-022594-fx044gcd	1225	18	lesions	lesion	NNS
cord-022594-fx044gcd	1225	19	.	.	.
cord-022594-fx044gcd	1226	1	The	the	DT
cord-022594-fx044gcd	1226	2	reason	reason	NN
cord-022594-fx044gcd	1226	3	for	for	IN
cord-022594-fx044gcd	1226	4	this	this	DT
cord-022594-fx044gcd	1226	5	peculiar	peculiar	JJ
cord-022594-fx044gcd	1226	6	alternating	alternate	VBG
cord-022594-fx044gcd	1226	7	pattern	pattern	NN
cord-022594-fx044gcd	1226	8	is	be	VBZ
cord-022594-fx044gcd	1226	9	unknown	unknown	JJ
cord-022594-fx044gcd	1226	10	.	.	.
cord-022594-fx044gcd	1227	1	Schilder	Schilder	NNP
cord-022594-fx044gcd	1227	2	's	's	POS
cord-022594-fx044gcd	1227	3	myelinoclastic	myelinoclastic	JJ
cord-022594-fx044gcd	1227	4	diffuse	diffuse	JJ
cord-022594-fx044gcd	1227	5	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1227	6	is	be	VBZ
cord-022594-fx044gcd	1227	7	another	another	DT
cord-022594-fx044gcd	1227	8	rare	rare	JJ
cord-022594-fx044gcd	1227	9	condition	condition	NN
cord-022594-fx044gcd	1227	10	that	that	WDT
cord-022594-fx044gcd	1227	11	may	may	MD
cord-022594-fx044gcd	1227	12	be	be	VB
cord-022594-fx044gcd	1227	13	confused	confuse	VBN
cord-022594-fx044gcd	1227	14	with	with	IN
cord-022594-fx044gcd	1227	15	ADEM	ADEM	NNP
cord-022594-fx044gcd	1227	16	or	or	CC
cord-022594-fx044gcd	1227	17	other	other	JJ
cord-022594-fx044gcd	1227	18	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1227	19	conditions	condition	NNS
cord-022594-fx044gcd	1227	20	.	.	.
cord-022594-fx044gcd	1228	1	This	this	DT
cord-022594-fx044gcd	1228	2	progressive	progressive	JJ
cord-022594-fx044gcd	1228	3	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1228	4	disorder	disorder	NN
cord-022594-fx044gcd	1228	5	usually	usually	RB
cord-022594-fx044gcd	1228	6	begins	begin	VBZ
cord-022594-fx044gcd	1228	7	in	in	IN
cord-022594-fx044gcd	1228	8	childhood	childhood	NN
cord-022594-fx044gcd	1228	9	.	.	.
cord-022594-fx044gcd	1229	1	The	the	DT
cord-022594-fx044gcd	1229	2	features	feature	NNS
cord-022594-fx044gcd	1229	3	are	be	VBP
cord-022594-fx044gcd	1229	4	often	often	RB
cord-022594-fx044gcd	1229	5	atypical	atypical	JJ
cord-022594-fx044gcd	1229	6	and	and	CC
cord-022594-fx044gcd	1229	7	include	include	VBP
cord-022594-fx044gcd	1229	8	dementia	dementia	NN
cord-022594-fx044gcd	1229	9	,	,	,
cord-022594-fx044gcd	1229	10	aphasia	aphasia	NNP
cord-022594-fx044gcd	1229	11	,	,	,
cord-022594-fx044gcd	1229	12	homonymous	homonymous	JJ
cord-022594-fx044gcd	1229	13	hemianopia	hemianopia	NNP
cord-022594-fx044gcd	1229	14	,	,	,
cord-022594-fx044gcd	1229	15	seizures	seizure	NNS
cord-022594-fx044gcd	1229	16	,	,	,
cord-022594-fx044gcd	1229	17	psychosis	psychosis	NN
cord-022594-fx044gcd	1229	18	,	,	,
cord-022594-fx044gcd	1229	19	elevated	elevated	JJ
cord-022594-fx044gcd	1229	20	intracranial	intracranial	JJ
cord-022594-fx044gcd	1229	21	pressure	pressure	NN
cord-022594-fx044gcd	1229	22	,	,	,
cord-022594-fx044gcd	1229	23	and	and	CC
cord-022594-fx044gcd	1229	24	the	the	DT
cord-022594-fx044gcd	1229	25	absence	absence	NN
cord-022594-fx044gcd	1229	26	of	of	IN
cord-022594-fx044gcd	1229	27	OCBs	ocb	NNS
cord-022594-fx044gcd	1229	28	.	.	.
cord-022594-fx044gcd	1230	1	The	the	DT
cord-022594-fx044gcd	1230	2	most	most	RBS
cord-022594-fx044gcd	1230	3	characteristic	characteristic	JJ
cord-022594-fx044gcd	1230	4	finding	finding	NN
cord-022594-fx044gcd	1230	5	is	be	VBZ
cord-022594-fx044gcd	1230	6	the	the	DT
cord-022594-fx044gcd	1230	7	presence	presence	NN
cord-022594-fx044gcd	1230	8	of	of	IN
cord-022594-fx044gcd	1230	9	two	two	CD
cord-022594-fx044gcd	1230	10	large	large	JJ
cord-022594-fx044gcd	1230	11	,	,	,
cord-022594-fx044gcd	1230	12	roughly	roughly	RB
cord-022594-fx044gcd	1230	13	symmetrical	symmetrical	JJ
cord-022594-fx044gcd	1230	14	lesions	lesion	NNS
cord-022594-fx044gcd	1230	15	on	on	IN
cord-022594-fx044gcd	1230	16	MRI	MRI	NNP
cord-022594-fx044gcd	1230	17	,	,	,
cord-022594-fx044gcd	1230	18	one	one	CD
cord-022594-fx044gcd	1230	19	in	in	IN
cord-022594-fx044gcd	1230	20	each	each	DT
cord-022594-fx044gcd	1230	21	hemisphere	hemisphere	NN
cord-022594-fx044gcd	1230	22	.	.	.
cord-022594-fx044gcd	1231	1	The	the	DT
cord-022594-fx044gcd	1231	2	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1231	3	is	be	VBZ
cord-022594-fx044gcd	1231	4	made	make	VBN
cord-022594-fx044gcd	1231	5	by	by	IN
cord-022594-fx044gcd	1231	6	excluding	exclude	VBG
cord-022594-fx044gcd	1231	7	the	the	DT
cord-022594-fx044gcd	1231	8	known	know	VBN
cord-022594-fx044gcd	1231	9	inherited	inherit	VBN
cord-022594-fx044gcd	1231	10	leukodystrophies	leukodystrophie	NNS
cord-022594-fx044gcd	1231	11	,	,	,
cord-022594-fx044gcd	1231	12	especially	especially	RB
cord-022594-fx044gcd	1231	13	adrenoleukodystrophy	adrenoleukodystrophy	NN
cord-022594-fx044gcd	1231	14	.	.	.
cord-022594-fx044gcd	1232	1	MANAGEMENT	management	NN
cord-022594-fx044gcd	1232	2	.	.	.
cord-022594-fx044gcd	1233	1	Treatment	treatment	NN
cord-022594-fx044gcd	1233	2	with	with	IN
cord-022594-fx044gcd	1233	3	intravenous	intravenous	JJ
cord-022594-fx044gcd	1233	4	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	1233	5	seems	seem	VBZ
cord-022594-fx044gcd	1233	6	to	to	TO
cord-022594-fx044gcd	1233	7	halt	halt	VB
cord-022594-fx044gcd	1233	8	progression	progression	NN
cord-022594-fx044gcd	1233	9	and	and	CC
cord-022594-fx044gcd	1233	10	allow	allow	VB
cord-022594-fx044gcd	1233	11	recovery	recovery	NN
cord-022594-fx044gcd	1233	12	to	to	TO
cord-022594-fx044gcd	1233	13	begin	begin	VB
cord-022594-fx044gcd	1233	14	sooner	soon	RBR
cord-022594-fx044gcd	1233	15	,	,	,
cord-022594-fx044gcd	1233	16	just	just	RB
cord-022594-fx044gcd	1233	17	as	as	IN
cord-022594-fx044gcd	1233	18	with	with	IN
cord-022594-fx044gcd	1233	19	MS	MS	NNP
cord-022594-fx044gcd	1233	20	.	.	.
cord-022594-fx044gcd	1234	1	Plasma	plasma	NN
cord-022594-fx044gcd	1234	2	exchange	exchange	NN
cord-022594-fx044gcd	1234	3	can	can	MD
cord-022594-fx044gcd	1234	4	be	be	VB
cord-022594-fx044gcd	1234	5	tried	try	VBN
cord-022594-fx044gcd	1234	6	in	in	IN
cord-022594-fx044gcd	1234	7	those	those	DT
cord-022594-fx044gcd	1234	8	with	with	IN
cord-022594-fx044gcd	1234	9	severe	severe	JJ
cord-022594-fx044gcd	1234	10	deficits	deficit	NNS
cord-022594-fx044gcd	1234	11	and	and	CC
cord-022594-fx044gcd	1234	12	little	little	JJ
cord-022594-fx044gcd	1234	13	response	response	NN
cord-022594-fx044gcd	1234	14	to	to	IN
cord-022594-fx044gcd	1234	15	corticosteroids	corticosteroid	NNS
cord-022594-fx044gcd	1234	16	.	.	.
cord-022594-fx044gcd	1235	1	IVIG	IVIG	NNP
cord-022594-fx044gcd	1235	2	has	have	VBZ
cord-022594-fx044gcd	1235	3	also	also	RB
cord-022594-fx044gcd	1235	4	been	be	VBN
cord-022594-fx044gcd	1235	5	used	use	VBN
cord-022594-fx044gcd	1235	6	successfully	successfully	RB
cord-022594-fx044gcd	1235	7	according	accord	VBG
cord-022594-fx044gcd	1235	8	to	to	IN
cord-022594-fx044gcd	1235	9	case	case	NN
cord-022594-fx044gcd	1235	10	reports	report	NNS
cord-022594-fx044gcd	1235	11	in	in	IN
cord-022594-fx044gcd	1235	12	the	the	DT
cord-022594-fx044gcd	1235	13	literature	literature	NN
cord-022594-fx044gcd	1235	14	.	.	.
cord-022594-fx044gcd	1236	1	One	one	CD
cord-022594-fx044gcd	1236	2	fulminant	fulminant	JJ
cord-022594-fx044gcd	1236	3	case	case	NN
cord-022594-fx044gcd	1236	4	responded	respond	VBD
cord-022594-fx044gcd	1236	5	to	to	IN
cord-022594-fx044gcd	1236	6	hypothermia	hypothermia	NN
cord-022594-fx044gcd	1236	7	only	only	RB
cord-022594-fx044gcd	1236	8	.	.	.
cord-022594-fx044gcd	1237	1	Genetics	genetic	NNS
cord-022594-fx044gcd	1237	2	of	of	IN
cord-022594-fx044gcd	1237	3	multiple	multiple	JJ
cord-022594-fx044gcd	1237	4	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1237	5	Utility	utility	NN
cord-022594-fx044gcd	1237	6	of	of	IN
cord-022594-fx044gcd	1237	7	MRI	MRI	NNP
cord-022594-fx044gcd	1237	8	in	in	IN
cord-022594-fx044gcd	1237	9	suspected	suspect	VBN
cord-022594-fx044gcd	1237	10	MS	MS	NNP
cord-022594-fx044gcd	1238	1	The	the	DT
cord-022594-fx044gcd	1238	2	use	use	NN
cord-022594-fx044gcd	1238	3	of	of	IN
cord-022594-fx044gcd	1238	4	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	1238	5	(	(	-LRB-
cord-022594-fx044gcd	1238	6	Novantrone	Novantrone	NNP
cord-022594-fx044gcd	1238	7	)	)	-RRB-
cord-022594-fx044gcd	1238	8	for	for	IN
cord-022594-fx044gcd	1238	9	the	the	DT
cord-022594-fx044gcd	1238	10	treatment	treatment	NN
cord-022594-fx044gcd	1238	11	of	of	IN
cord-022594-fx044gcd	1238	12	multiple	multiple	JJ
cord-022594-fx044gcd	1238	13	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1238	14	Disease	Disease	NNP
cord-022594-fx044gcd	1238	15	modifying	modify	VBG
cord-022594-fx044gcd	1238	16	therapies	therapy	NNS
cord-022594-fx044gcd	1238	17	in	in	IN
cord-022594-fx044gcd	1238	18	multiple	multiple	JJ
cord-022594-fx044gcd	1238	19	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1238	20	Natural	natural	JJ
cord-022594-fx044gcd	1238	21	history	history	NN
cord-022594-fx044gcd	1238	22	of	of	IN
cord-022594-fx044gcd	1238	23	multiple	multiple	JJ
cord-022594-fx044gcd	1238	24	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1239	1	A	a	DT
cord-022594-fx044gcd	1239	2	randomized	randomized	JJ
cord-022594-fx044gcd	1239	3	study	study	NN
cord-022594-fx044gcd	1239	4	of	of	IN
cord-022594-fx044gcd	1239	5	two	two	CD
cord-022594-fx044gcd	1239	6	interferon	interferon	NN
cord-022594-fx044gcd	1239	7	-	-	HYPH
cord-022594-fx044gcd	1239	8	beta	beta	NN
cord-022594-fx044gcd	1239	9	treatments	treatment	NNS
cord-022594-fx044gcd	1239	10	in	in	IN
cord-022594-fx044gcd	1239	11	relapsing	relapse	VBG
cord-022594-fx044gcd	1239	12	-	-	HYPH
cord-022594-fx044gcd	1239	13	remitting	remit	VBG
cord-022594-fx044gcd	1239	14	multiple	multiple	JJ
cord-022594-fx044gcd	1239	15	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1239	16	Cortical	cortical	JJ
cord-022594-fx044gcd	1239	17	lesions	lesion	NNS
cord-022594-fx044gcd	1239	18	and	and	CC
cord-022594-fx044gcd	1239	19	brain	brain	NN
cord-022594-fx044gcd	1239	20	atrophy	atrophy	NN
cord-022594-fx044gcd	1239	21	in	in	IN
cord-022594-fx044gcd	1239	22	MS	MS	NNP
cord-022594-fx044gcd	1240	1	The	the	DT
cord-022594-fx044gcd	1240	2	pathology	pathology	NN
cord-022594-fx044gcd	1240	3	of	of	IN
cord-022594-fx044gcd	1240	4	multiple	multiple	JJ
cord-022594-fx044gcd	1240	5	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1240	6	Management	Management	NNP
cord-022594-fx044gcd	1240	7	of	of	IN
cord-022594-fx044gcd	1240	8	multiple	multiple	JJ
cord-022594-fx044gcd	1240	9	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1240	10	:	:	:
cord-022594-fx044gcd	1240	11	current	current	JJ
cord-022594-fx044gcd	1240	12	trials	trial	NNS
cord-022594-fx044gcd	1240	13	and	and	CC
cord-022594-fx044gcd	1240	14	future	future	JJ
cord-022594-fx044gcd	1240	15	options	option	NNS
cord-022594-fx044gcd	1241	1	Competing	compete	VBG
cord-022594-fx044gcd	1241	2	interests	interest	NNS
cord-022594-fx044gcd	1241	3	in	in	IN
cord-022594-fx044gcd	1241	4	multiple	multiple	JJ
cord-022594-fx044gcd	1241	5	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1241	6	research	research	NN
cord-022594-fx044gcd	1241	7	Diagnostic	diagnostic	JJ
cord-022594-fx044gcd	1241	8	criteria	criterion	NNS
cord-022594-fx044gcd	1241	9	for	for	IN
cord-022594-fx044gcd	1241	10	multiple	multiple	JJ
cord-022594-fx044gcd	1241	11	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1241	12	:	:	:
cord-022594-fx044gcd	1242	1	2005	2005	CD
cord-022594-fx044gcd	1242	2	revisions	revision	NNS
cord-022594-fx044gcd	1242	3	to	to	IN
cord-022594-fx044gcd	1242	4	the	the	DT
cord-022594-fx044gcd	1242	5	"	"	``
cord-022594-fx044gcd	1242	6	McDonald	McDonald	NNP
cord-022594-fx044gcd	1242	7	Criteria	Criteria	NNP
cord-022594-fx044gcd	1242	8	Immunization	Immunization	NNP
cord-022594-fx044gcd	1242	9	and	and	CC
cord-022594-fx044gcd	1242	10	multiple	multiple	JJ
cord-022594-fx044gcd	1242	11	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1242	12	:	:	:
cord-022594-fx044gcd	1242	13	A	a	DT
cord-022594-fx044gcd	1242	14	summary	summary	NN
cord-022594-fx044gcd	1242	15	of	of	IN
cord-022594-fx044gcd	1242	16	published	publish	VBN
cord-022594-fx044gcd	1242	17	evidence	evidence	NN
cord-022594-fx044gcd	1242	18	and	and	CC
cord-022594-fx044gcd	1242	19	recommendations	recommendation	NNS
cord-022594-fx044gcd	1242	20	Revised	revise	VBD
cord-022594-fx044gcd	1242	21	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	1242	22	criteria	criterion	NNS
cord-022594-fx044gcd	1242	23	for	for	IN
cord-022594-fx044gcd	1242	24	neuromyelitisi	neuromyelitisi	NNP
cord-022594-fx044gcd	1243	1	optica	optica	NNP
cord-022594-fx044gcd	1243	2	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	1244	1	optica	optica	NNP
cord-022594-fx044gcd	1244	2	Randomized	Randomized	NNP
cord-022594-fx044gcd	1244	3	controlled	control	VBN
cord-022594-fx044gcd	1244	4	trials	trial	NNS
cord-022594-fx044gcd	1244	5	to	to	TO
cord-022594-fx044gcd	1244	6	assess	assess	VB
cord-022594-fx044gcd	1244	7	therapies	therapy	NNS
cord-022594-fx044gcd	1244	8	for	for	IN
cord-022594-fx044gcd	1244	9	multiple	multiple	JJ
cord-022594-fx044gcd	1244	10	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1245	1	Does	do	VBZ
cord-022594-fx044gcd	1245	2	the	the	DT
cord-022594-fx044gcd	1245	3	history	history	NN
cord-022594-fx044gcd	1245	4	of	of	IN
cord-022594-fx044gcd	1245	5	multiple	multiple	JJ
cord-022594-fx044gcd	1245	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1245	7	go	go	VBP
cord-022594-fx044gcd	1245	8	back	back	RB
cord-022594-fx044gcd	1245	9	as	as	RB
cord-022594-fx044gcd	1245	10	far	far	RB
cord-022594-fx044gcd	1245	11	as	as	IN
cord-022594-fx044gcd	1245	12	the	the	DT
cord-022594-fx044gcd	1245	13	14th	14th	JJ
cord-022594-fx044gcd	1245	14	century	century	NN
cord-022594-fx044gcd	1245	15	?	?	.
cord-022594-fx044gcd	1246	1	The	the	DT
cord-022594-fx044gcd	1246	2	150-year	150-year	CD
cord-022594-fx044gcd	1246	3	anniversary	anniversary	NN
cord-022594-fx044gcd	1246	4	of	of	IN
cord-022594-fx044gcd	1246	5	multiple	multiple	JJ
cord-022594-fx044gcd	1246	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1246	7	:	:	:
cord-022594-fx044gcd	1246	8	Does	do	VBZ
cord-022594-fx044gcd	1246	9	its	-PRON-	PRP$
cord-022594-fx044gcd	1246	10	early	early	JJ
cord-022594-fx044gcd	1246	11	history	history	NN
cord-022594-fx044gcd	1246	12	give	give	VBP
cord-022594-fx044gcd	1246	13	an	an	DT
cord-022594-fx044gcd	1246	14	etiological	etiological	JJ
cord-022594-fx044gcd	1246	15	clue	clue	NN
cord-022594-fx044gcd	1246	16	?	?	.
cord-022594-fx044gcd	1247	1	Encephalomyelitis	Encephalomyelitis	NNP
cord-022594-fx044gcd	1247	2	accompanied	accompany	VBN
cord-022594-fx044gcd	1247	3	by	by	IN
cord-022594-fx044gcd	1247	4	myelin	myelin	JJ
cord-022594-fx044gcd	1247	5	destruction	destruction	NN
cord-022594-fx044gcd	1247	6	experimentally	experimentally	RB
cord-022594-fx044gcd	1247	7	produced	produce	VBN
cord-022594-fx044gcd	1247	8	in	in	IN
cord-022594-fx044gcd	1247	9	monkeys	monkey	NNS
cord-022594-fx044gcd	1247	10	Morphological	morphological	JJ
cord-022594-fx044gcd	1247	11	aspects	aspect	NNS
cord-022594-fx044gcd	1247	12	of	of	IN
cord-022594-fx044gcd	1247	13	myelin	myelin	NN
cord-022594-fx044gcd	1247	14	and	and	CC
cord-022594-fx044gcd	1247	15	myelination	myelination	NN
cord-022594-fx044gcd	1247	16	T	t	NN
cord-022594-fx044gcd	1247	17	-	-	HYPH
cord-022594-fx044gcd	1247	18	cell	cell	NN
cord-022594-fx044gcd	1247	19	subsets	subset	NNS
cord-022594-fx044gcd	1247	20	in	in	IN
cord-022594-fx044gcd	1247	21	multiple	multiple	JJ
cord-022594-fx044gcd	1247	22	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1247	23	:	:	:
cord-022594-fx044gcd	1247	24	A	a	DT
cord-022594-fx044gcd	1247	25	comparative	comparative	JJ
cord-022594-fx044gcd	1247	26	study	study	NN
cord-022594-fx044gcd	1247	27	between	between	IN
cord-022594-fx044gcd	1247	28	cell	cell	NN
cord-022594-fx044gcd	1247	29	surface	surface	NN
cord-022594-fx044gcd	1247	30	antigens	antigen	NNS
cord-022594-fx044gcd	1247	31	and	and	CC
cord-022594-fx044gcd	1247	32	function	function	VB
cord-022594-fx044gcd	1247	33	Molecular	molecular	JJ
cord-022594-fx044gcd	1247	34	mimicry	mimicry	NN
cord-022594-fx044gcd	1247	35	in	in	IN
cord-022594-fx044gcd	1247	36	T	T	NNP
cord-022594-fx044gcd	1247	37	cellmediated	cellmediate	VBN
cord-022594-fx044gcd	1247	38	autoimmunity	autoimmunity	NN
cord-022594-fx044gcd	1247	39	:	:	:
cord-022594-fx044gcd	1247	40	Viral	viral	JJ
cord-022594-fx044gcd	1247	41	peptides	peptide	NNS
cord-022594-fx044gcd	1247	42	activate	activate	VBP
cord-022594-fx044gcd	1247	43	human	human	JJ
cord-022594-fx044gcd	1247	44	T	t	NN
cord-022594-fx044gcd	1247	45	cell	cell	NN
cord-022594-fx044gcd	1247	46	clones	clone	NNS
cord-022594-fx044gcd	1247	47	specific	specific	JJ
cord-022594-fx044gcd	1247	48	for	for	IN
cord-022594-fx044gcd	1247	49	myelin	myelin	JJ
cord-022594-fx044gcd	1247	50	basic	basic	JJ
cord-022594-fx044gcd	1247	51	protein	protein	NN
cord-022594-fx044gcd	1247	52	T	T	NNP
cord-022594-fx044gcd	1247	53	cells	cell	NNS
cord-022594-fx044gcd	1247	54	responsive	responsive	JJ
cord-022594-fx044gcd	1247	55	to	to	IN
cord-022594-fx044gcd	1247	56	myelin	myelin	JJ
cord-022594-fx044gcd	1247	57	basic	basic	JJ
cord-022594-fx044gcd	1247	58	protein	protein	NN
cord-022594-fx044gcd	1247	59	in	in	IN
cord-022594-fx044gcd	1247	60	patients	patient	NNS
cord-022594-fx044gcd	1247	61	with	with	IN
cord-022594-fx044gcd	1247	62	multiple	multiple	JJ
cord-022594-fx044gcd	1247	63	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1248	1	The	the	DT
cord-022594-fx044gcd	1248	2	CD4-Th1	CD4-Th1	NNP
cord-022594-fx044gcd	1248	3	model	model	NN
cord-022594-fx044gcd	1248	4	for	for	IN
cord-022594-fx044gcd	1248	5	multiple	multiple	JJ
cord-022594-fx044gcd	1248	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1248	7	:	:	:
cord-022594-fx044gcd	1249	1	A	a	DT
cord-022594-fx044gcd	1249	2	critical	critical	JJ
cord-022594-fx044gcd	1249	3	Experimental	experimental	JJ
cord-022594-fx044gcd	1249	4	allergic	allergic	JJ
cord-022594-fx044gcd	1249	5	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	1249	6	:	:	:
cord-022594-fx044gcd	1249	7	A	a	DT
cord-022594-fx044gcd	1249	8	misleading	misleading	JJ
cord-022594-fx044gcd	1249	9	model	model	NN
cord-022594-fx044gcd	1249	10	of	of	IN
cord-022594-fx044gcd	1249	11	multiple	multiple	JJ
cord-022594-fx044gcd	1249	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1249	13	IgG	IgG	NNP
cord-022594-fx044gcd	1249	14	marker	marker	NN
cord-022594-fx044gcd	1249	15	of	of	IN
cord-022594-fx044gcd	1249	16	optic	optic	JJ
cord-022594-fx044gcd	1249	17	-	-	HYPH
cord-022594-fx044gcd	1249	18	spinal	spinal	JJ
cord-022594-fx044gcd	1249	19	multiple	multiple	JJ
cord-022594-fx044gcd	1249	20	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1249	21	binds	bind	VBZ
cord-022594-fx044gcd	1249	22	to	to	IN
cord-022594-fx044gcd	1249	23	the	the	DT
cord-022594-fx044gcd	1249	24	aquaporin-4	aquaporin-4	NNP
cord-022594-fx044gcd	1249	25	water	water	NN
cord-022594-fx044gcd	1249	26	channel	channel	NN
cord-022594-fx044gcd	1249	27	Isolation	isolation	NN
cord-022594-fx044gcd	1249	28	of	of	IN
cord-022594-fx044gcd	1249	29	herpes	herpes	NNP
cord-022594-fx044gcd	1249	30	simplex	simplex	NNP
cord-022594-fx044gcd	1249	31	virus	virus	NN
cord-022594-fx044gcd	1249	32	type	type	NN
cord-022594-fx044gcd	1249	33	1	1	CD
cord-022594-fx044gcd	1249	34	during	during	IN
cord-022594-fx044gcd	1249	35	first	first	JJ
cord-022594-fx044gcd	1249	36	attack	attack	NN
cord-022594-fx044gcd	1249	37	of	of	IN
cord-022594-fx044gcd	1249	38	multiple	multiple	JJ
cord-022594-fx044gcd	1249	39	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1249	40	Isolation	isolation	NN
cord-022594-fx044gcd	1249	41	of	of	IN
cord-022594-fx044gcd	1249	42	virus	virus	NN
cord-022594-fx044gcd	1249	43	from	from	IN
cord-022594-fx044gcd	1249	44	the	the	DT
cord-022594-fx044gcd	1249	45	spinal	spinal	JJ
cord-022594-fx044gcd	1249	46	fluid	fluid	NN
cord-022594-fx044gcd	1249	47	of	of	IN
cord-022594-fx044gcd	1249	48	three	three	CD
cord-022594-fx044gcd	1249	49	patients	patient	NNS
cord-022594-fx044gcd	1249	50	with	with	IN
cord-022594-fx044gcd	1249	51	multiple	multiple	JJ
cord-022594-fx044gcd	1249	52	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1249	53	and	and	CC
cord-022594-fx044gcd	1249	54	one	one	CD
cord-022594-fx044gcd	1249	55	with	with	IN
cord-022594-fx044gcd	1249	56	amyotrophic	amyotrophic	JJ
cord-022594-fx044gcd	1249	57	lateral	lateral	JJ
cord-022594-fx044gcd	1249	58	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1249	59	Plaque	Plaque	NNP
cord-022594-fx044gcd	1249	60	-	-	HYPH
cord-022594-fx044gcd	1249	61	associated	associate	VBN
cord-022594-fx044gcd	1249	62	expression	expression	NN
cord-022594-fx044gcd	1249	63	of	of	IN
cord-022594-fx044gcd	1249	64	human	human	JJ
cord-022594-fx044gcd	1249	65	herpesvirus	herpesvirus	NN
cord-022594-fx044gcd	1249	66	6	6	CD
cord-022594-fx044gcd	1249	67	in	in	IN
cord-022594-fx044gcd	1249	68	multiple	multiple	JJ
cord-022594-fx044gcd	1249	69	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1249	70	Oligodendrocytes	Oligodendrocytes	NNPS
cord-022594-fx044gcd	1249	71	and	and	CC
cord-022594-fx044gcd	1249	72	oligodendrocyte	oligodendrocyte	NNP
cord-022594-fx044gcd	1249	73	/	/	SYM
cord-022594-fx044gcd	1249	74	type-2	type-2	NNP
cord-022594-fx044gcd	1249	75	astrocyte	astrocyte	NNP
cord-022594-fx044gcd	1249	76	progenitor	progenitor	NN
cord-022594-fx044gcd	1249	77	cells	cell	NNS
cord-022594-fx044gcd	1249	78	of	of	IN
cord-022594-fx044gcd	1249	79	adult	adult	NN
cord-022594-fx044gcd	1249	80	rats	rat	NNS
cord-022594-fx044gcd	1249	81	are	be	VBP
cord-022594-fx044gcd	1249	82	specifically	specifically	RB
cord-022594-fx044gcd	1249	83	susceptible	susceptible	JJ
cord-022594-fx044gcd	1249	84	to	to	IN
cord-022594-fx044gcd	1249	85	the	the	DT
cord-022594-fx044gcd	1249	86	lytic	lytic	JJ
cord-022594-fx044gcd	1249	87	effects	effect	NNS
cord-022594-fx044gcd	1249	88	of	of	IN
cord-022594-fx044gcd	1249	89	complement	complement	NN
cord-022594-fx044gcd	1249	90	in	in	IN
cord-022594-fx044gcd	1249	91	absence	absence	NN
cord-022594-fx044gcd	1249	92	of	of	IN
cord-022594-fx044gcd	1249	93	antibody	antibody	NN
cord-022594-fx044gcd	1249	94	Experimental	experimental	JJ
cord-022594-fx044gcd	1249	95	autoimmune	autoimmune	JJ
cord-022594-fx044gcd	1249	96	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	1249	97	:	:	:
cord-022594-fx044gcd	1250	1	immunotherapy	immunotherapy	NN
cord-022594-fx044gcd	1250	2	with	with	IN
cord-022594-fx044gcd	1250	3	anti	anti	JJ
cord-022594-fx044gcd	1250	4	-	-	JJ
cord-022594-fx044gcd	1250	5	tumor	tumor	JJ
cord-022594-fx044gcd	1250	6	necrosis	necrosis	NN
cord-022594-fx044gcd	1250	7	factor	factor	NN
cord-022594-fx044gcd	1250	8	antibodies	antibody	NNS
cord-022594-fx044gcd	1250	9	and	and	CC
cord-022594-fx044gcd	1250	10	soluble	soluble	JJ
cord-022594-fx044gcd	1250	11	tumor	tumor	NN
cord-022594-fx044gcd	1250	12	necrosis	necrosis	NN
cord-022594-fx044gcd	1250	13	factor	factor	NN
cord-022594-fx044gcd	1250	14	receptors	receptor	NNS
cord-022594-fx044gcd	1250	15	Evidence	evidence	NN
cord-022594-fx044gcd	1250	16	for	for	IN
cord-022594-fx044gcd	1250	17	pathogenic	pathogenic	JJ
cord-022594-fx044gcd	1250	18	heterogeneity	heterogeneity	NN
cord-022594-fx044gcd	1250	19	in	in	IN
cord-022594-fx044gcd	1250	20	multiple	multiple	JJ
cord-022594-fx044gcd	1250	21	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1250	22	Transected	transect	VBN
cord-022594-fx044gcd	1250	23	neurites	neurite	NNS
cord-022594-fx044gcd	1250	24	,	,	,
cord-022594-fx044gcd	1250	25	apoptotic	apoptotic	JJ
cord-022594-fx044gcd	1250	26	neurons	neuron	NNS
cord-022594-fx044gcd	1250	27	,	,	,
cord-022594-fx044gcd	1250	28	and	and	CC
cord-022594-fx044gcd	1250	29	reduced	reduce	VBN
cord-022594-fx044gcd	1250	30	inflammation	inflammation	NN
cord-022594-fx044gcd	1250	31	in	in	IN
cord-022594-fx044gcd	1250	32	cortical	cortical	JJ
cord-022594-fx044gcd	1250	33	multiple	multiple	JJ
cord-022594-fx044gcd	1250	34	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1250	35	lesions	lesion	NNS
cord-022594-fx044gcd	1250	36	Cortical	cortical	JJ
cord-022594-fx044gcd	1250	37	demyelination	demyelination	NN
cord-022594-fx044gcd	1250	38	and	and	CC
cord-022594-fx044gcd	1250	39	diffuse	diffuse	VB
cord-022594-fx044gcd	1250	40	white	white	JJ
cord-022594-fx044gcd	1250	41	matter	matter	NN
cord-022594-fx044gcd	1250	42	injury	injury	NN
cord-022594-fx044gcd	1250	43	in	in	IN
cord-022594-fx044gcd	1250	44	multiple	multiple	JJ
cord-022594-fx044gcd	1250	45	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1251	1	A	a	DT
cord-022594-fx044gcd	1251	2	genetic	genetic	JJ
cord-022594-fx044gcd	1251	3	basis	basis	NN
cord-022594-fx044gcd	1251	4	for	for	IN
cord-022594-fx044gcd	1251	5	familial	familial	JJ
cord-022594-fx044gcd	1251	6	aggregation	aggregation	NN
cord-022594-fx044gcd	1251	7	in	in	IN
cord-022594-fx044gcd	1251	8	multiple	multiple	JJ
cord-022594-fx044gcd	1251	9	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1251	10	.	.	.
cord-022594-fx044gcd	1252	1	Canadian	Canadian	NNP
cord-022594-fx044gcd	1252	2	Collaborative	Collaborative	NNP
cord-022594-fx044gcd	1252	3	Study	Study	NNP
cord-022594-fx044gcd	1252	4	Group	Group	NNP
cord-022594-fx044gcd	1252	5	Genetics	Genetics	NNP
cord-022594-fx044gcd	1252	6	of	of	IN
cord-022594-fx044gcd	1252	7	multiple	multiple	JJ
cord-022594-fx044gcd	1252	8	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1252	9	Multiple	multiple	JJ
cord-022594-fx044gcd	1252	10	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1252	11	:	:	:
cord-022594-fx044gcd	1252	12	Changing	change	VBG
cord-022594-fx044gcd	1252	13	times	time	NNS
cord-022594-fx044gcd	1252	14	Epidemiology	Epidemiology	NNP
cord-022594-fx044gcd	1252	15	of	of	IN
cord-022594-fx044gcd	1252	16	multiple	multiple	JJ
cord-022594-fx044gcd	1252	17	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1252	18	in	in	IN
cord-022594-fx044gcd	1252	19	U.S.	U.S.	NNP
cord-022594-fx044gcd	1252	20	veterans	veteran	NNS
cord-022594-fx044gcd	1252	21	:	:	:
cord-022594-fx044gcd	1252	22	V.	V.	NNP
cord-022594-fx044gcd	1252	23	Ancestry	Ancestry	NNP
cord-022594-fx044gcd	1252	24	and	and	CC
cord-022594-fx044gcd	1252	25	the	the	DT
cord-022594-fx044gcd	1252	26	risk	risk	NN
cord-022594-fx044gcd	1252	27	of	of	IN
cord-022594-fx044gcd	1252	28	multiple	multiple	JJ
cord-022594-fx044gcd	1252	29	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1252	30	Unusual	unusual	JJ
cord-022594-fx044gcd	1252	31	occurrence	occurrence	NN
cord-022594-fx044gcd	1252	32	on	on	IN
cord-022594-fx044gcd	1252	33	a	a	DT
cord-022594-fx044gcd	1252	34	tropical	tropical	JJ
cord-022594-fx044gcd	1252	35	island	island	NN
cord-022594-fx044gcd	1252	36	of	of	IN
cord-022594-fx044gcd	1252	37	multiple	multiple	JJ
cord-022594-fx044gcd	1252	38	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1253	1	When	when	WRB
cord-022594-fx044gcd	1253	2	is	be	VBZ
cord-022594-fx044gcd	1253	3	an	an	DT
cord-022594-fx044gcd	1253	4	apparent	apparent	JJ
cord-022594-fx044gcd	1253	5	excess	excess	NN
cord-022594-fx044gcd	1253	6	of	of	IN
cord-022594-fx044gcd	1253	7	neurologic	neurologic	JJ
cord-022594-fx044gcd	1253	8	cases	case	NNS
cord-022594-fx044gcd	1253	9	epidemiologically	epidemiologically	RB
cord-022594-fx044gcd	1253	10	significant	significant	JJ
cord-022594-fx044gcd	1253	11	Smoking	smoking	NN
cord-022594-fx044gcd	1253	12	is	be	VBZ
cord-022594-fx044gcd	1253	13	a	a	DT
cord-022594-fx044gcd	1253	14	risk	risk	NN
cord-022594-fx044gcd	1253	15	factor	factor	NN
cord-022594-fx044gcd	1253	16	for	for	IN
cord-022594-fx044gcd	1253	17	multiple	multiple	JJ
cord-022594-fx044gcd	1253	18	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1253	19	Environmental	environmental	JJ
cord-022594-fx044gcd	1253	20	risk	risk	NN
cord-022594-fx044gcd	1253	21	factors	factor	NNS
cord-022594-fx044gcd	1253	22	in	in	IN
cord-022594-fx044gcd	1253	23	multiple	multiple	JJ
cord-022594-fx044gcd	1253	24	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1253	25	:	:	:
cord-022594-fx044gcd	1253	26	Causes	cause	NNS
cord-022594-fx044gcd	1253	27	,	,	,
cord-022594-fx044gcd	1253	28	triggers	trigger	NNS
cord-022594-fx044gcd	1253	29	,	,	,
cord-022594-fx044gcd	1253	30	and	and	CC
cord-022594-fx044gcd	1253	31	patient	patient	JJ
cord-022594-fx044gcd	1253	32	autonomy	autonomy	NN
cord-022594-fx044gcd	1253	33	Pregnancy	pregnancy	NN
cord-022594-fx044gcd	1253	34	is	be	VBZ
cord-022594-fx044gcd	1253	35	associated	associate	VBN
cord-022594-fx044gcd	1253	36	with	with	IN
cord-022594-fx044gcd	1253	37	a	a	DT
cord-022594-fx044gcd	1253	38	lower	low	JJR
cord-022594-fx044gcd	1253	39	risk	risk	NN
cord-022594-fx044gcd	1253	40	of	of	IN
cord-022594-fx044gcd	1253	41	onset	onset	NN
cord-022594-fx044gcd	1253	42	and	and	CC
cord-022594-fx044gcd	1253	43	a	a	DT
cord-022594-fx044gcd	1253	44	better	well	JJR
cord-022594-fx044gcd	1253	45	prognosis	prognosis	NN
cord-022594-fx044gcd	1253	46	in	in	IN
cord-022594-fx044gcd	1253	47	multiple	multiple	JJ
cord-022594-fx044gcd	1253	48	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1253	49	Diagnosis	Diagnosis	NNP
cord-022594-fx044gcd	1253	50	of	of	IN
cord-022594-fx044gcd	1253	51	MS	MS	NNP
cord-022594-fx044gcd	1254	1	The	the	DT
cord-022594-fx044gcd	1254	2	natural	natural	JJ
cord-022594-fx044gcd	1254	3	history	history	NN
cord-022594-fx044gcd	1254	4	of	of	IN
cord-022594-fx044gcd	1254	5	recurrent	recurrent	JJ
cord-022594-fx044gcd	1254	6	optic	optic	JJ
cord-022594-fx044gcd	1254	7	neuritis	neuritis	NN
cord-022594-fx044gcd	1255	1	The	the	DT
cord-022594-fx044gcd	1255	2	prevalence	prevalence	NN
cord-022594-fx044gcd	1255	3	of	of	IN
cord-022594-fx044gcd	1255	4	cognitive	cognitive	JJ
cord-022594-fx044gcd	1255	5	impairment	impairment	NN
cord-022594-fx044gcd	1255	6	in	in	IN
cord-022594-fx044gcd	1255	7	a	a	DT
cord-022594-fx044gcd	1255	8	community	community	NN
cord-022594-fx044gcd	1255	9	survey	survey	NN
cord-022594-fx044gcd	1255	10	of	of	IN
cord-022594-fx044gcd	1255	11	multiple	multiple	JJ
cord-022594-fx044gcd	1255	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1255	13	Defining	define	VBG
cord-022594-fx044gcd	1255	14	the	the	DT
cord-022594-fx044gcd	1255	15	clinical	clinical	JJ
cord-022594-fx044gcd	1255	16	course	course	NN
cord-022594-fx044gcd	1255	17	of	of	IN
cord-022594-fx044gcd	1255	18	multiple	multiple	JJ
cord-022594-fx044gcd	1255	19	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1255	20	:	:	:
cord-022594-fx044gcd	1255	21	results	result	NNS
cord-022594-fx044gcd	1255	22	of	of	IN
cord-022594-fx044gcd	1255	23	an	an	DT
cord-022594-fx044gcd	1255	24	international	international	JJ
cord-022594-fx044gcd	1255	25	survey	survey	NN
cord-022594-fx044gcd	1255	26	.	.	.
cord-022594-fx044gcd	1256	1	National	National	NNP
cord-022594-fx044gcd	1256	2	Multiple	Multiple	NNP
cord-022594-fx044gcd	1256	3	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1256	4	Society	Society	NNP
cord-022594-fx044gcd	1256	5	(	(	-LRB-
cord-022594-fx044gcd	1256	6	USA	USA	NNP
cord-022594-fx044gcd	1256	7	)	)	-RRB-
cord-022594-fx044gcd	1256	8	Advisory	Advisory	NNP
cord-022594-fx044gcd	1256	9	Committee	Committee	NNP
cord-022594-fx044gcd	1256	10	on	on	IN
cord-022594-fx044gcd	1256	11	Clinical	Clinical	NNP
cord-022594-fx044gcd	1256	12	Trials	Trials	NNPS
cord-022594-fx044gcd	1256	13	of	of	IN
cord-022594-fx044gcd	1256	14	New	New	NNP
cord-022594-fx044gcd	1256	15	Agents	Agents	NNPS
cord-022594-fx044gcd	1256	16	in	in	IN
cord-022594-fx044gcd	1256	17	Multiple	Multiple	NNP
cord-022594-fx044gcd	1256	18	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1256	19	Epilepsy	Epilepsy	NNP
cord-022594-fx044gcd	1256	20	and	and	CC
cord-022594-fx044gcd	1257	1	multiple	multiple	JJ
cord-022594-fx044gcd	1257	2	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1257	3	Multiple	multiple	JJ
cord-022594-fx044gcd	1257	4	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1257	5	-	-	HYPH
cord-022594-fx044gcd	1257	6	associated	associate	VBN
cord-022594-fx044gcd	1257	7	uveitis	uveitis	NN
cord-022594-fx044gcd	1257	8	A	a	DT
cord-022594-fx044gcd	1257	9	reappraisal	reappraisal	NN
cord-022594-fx044gcd	1257	10	of	of	IN
cord-022594-fx044gcd	1257	11	the	the	DT
cord-022594-fx044gcd	1257	12	epidemiology	epidemiology	NN
cord-022594-fx044gcd	1257	13	of	of	IN
cord-022594-fx044gcd	1257	14	multiple	multiple	JJ
cord-022594-fx044gcd	1257	15	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1257	16	in	in	IN
cord-022594-fx044gcd	1257	17	Olmsted	Olmsted	NNP
cord-022594-fx044gcd	1257	18	County	County	NNP
cord-022594-fx044gcd	1257	19	Optic	Optic	NNP
cord-022594-fx044gcd	1257	20	neuritis	neuritis	NN
cord-022594-fx044gcd	1257	21	:	:	:
cord-022594-fx044gcd	1257	22	A	a	DT
cord-022594-fx044gcd	1257	23	population	population	NN
cord-022594-fx044gcd	1257	24	-	-	HYPH
cord-022594-fx044gcd	1257	25	based	base	VBN
cord-022594-fx044gcd	1257	26	study	study	NN
cord-022594-fx044gcd	1257	27	in	in	IN
cord-022594-fx044gcd	1257	28	Olmsted	Olmsted	NNP
cord-022594-fx044gcd	1257	29	County	County	NNP
cord-022594-fx044gcd	1258	1	The	the	DT
cord-022594-fx044gcd	1258	2	significance	significance	NN
cord-022594-fx044gcd	1258	3	of	of	IN
cord-022594-fx044gcd	1258	4	brain	brain	NN
cord-022594-fx044gcd	1258	5	magnetic	magnetic	JJ
cord-022594-fx044gcd	1258	6	resonance	resonance	NN
cord-022594-fx044gcd	1258	7	imaging	imaging	NN
cord-022594-fx044gcd	1258	8	abnormalities	abnormality	NNS
cord-022594-fx044gcd	1258	9	at	at	IN
cord-022594-fx044gcd	1258	10	presentation	presentation	NN
cord-022594-fx044gcd	1258	11	with	with	IN
cord-022594-fx044gcd	1258	12	clinically	clinically	RB
cord-022594-fx044gcd	1258	13	isolated	isolate	VBN
cord-022594-fx044gcd	1258	14	syndromes	syndrome	NNS
cord-022594-fx044gcd	1258	15	suggestive	suggestive	JJ
cord-022594-fx044gcd	1258	16	of	of	IN
cord-022594-fx044gcd	1258	17	multiple	multiple	JJ
cord-022594-fx044gcd	1258	18	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1258	19	.	.	.
cord-022594-fx044gcd	1259	1	A	a	DT
cord-022594-fx044gcd	1259	2	5-year	5-year	CD
cord-022594-fx044gcd	1259	3	follow	follow	NN
cord-022594-fx044gcd	1259	4	-	-	HYPH
cord-022594-fx044gcd	1259	5	up	up	NN
cord-022594-fx044gcd	1259	6	study	study	NN
cord-022594-fx044gcd	1259	7	Interscanner	Interscanner	NNP
cord-022594-fx044gcd	1259	8	variation	variation	NN
cord-022594-fx044gcd	1259	9	in	in	IN
cord-022594-fx044gcd	1259	10	brain	brain	NN
cord-022594-fx044gcd	1259	11	MRI	MRI	NNP
cord-022594-fx044gcd	1259	12	lesion	lesion	NN
cord-022594-fx044gcd	1259	13	load	load	NN
cord-022594-fx044gcd	1259	14	measurements	measurement	NNS
cord-022594-fx044gcd	1259	15	in	in	IN
cord-022594-fx044gcd	1259	16	MS	MS	NNP
cord-022594-fx044gcd	1259	17	:	:	:
cord-022594-fx044gcd	1259	18	Implications	implication	NNS
cord-022594-fx044gcd	1259	19	for	for	IN
cord-022594-fx044gcd	1259	20	clinical	clinical	JJ
cord-022594-fx044gcd	1259	21	trials	trial	NNS
cord-022594-fx044gcd	1260	1	The	the	DT
cord-022594-fx044gcd	1260	2	prognostic	prognostic	JJ
cord-022594-fx044gcd	1260	3	value	value	NN
cord-022594-fx044gcd	1260	4	of	of	IN
cord-022594-fx044gcd	1260	5	brain	brain	NN
cord-022594-fx044gcd	1260	6	MRI	MRI	NNP
cord-022594-fx044gcd	1260	7	in	in	IN
cord-022594-fx044gcd	1260	8	clinically	clinically	RB
cord-022594-fx044gcd	1260	9	isolated	isolate	VBN
cord-022594-fx044gcd	1260	10	syndromes	syndrome	NNS
cord-022594-fx044gcd	1260	11	of	of	IN
cord-022594-fx044gcd	1260	12	the	the	DT
cord-022594-fx044gcd	1260	13	CNS	CNS	NNP
cord-022594-fx044gcd	1260	14	.	.	.
cord-022594-fx044gcd	1261	1	A	a	DT
cord-022594-fx044gcd	1261	2	10-year	10-year	CD
cord-022594-fx044gcd	1261	3	follow	follow	NN
cord-022594-fx044gcd	1261	4	-	-	HYPH
cord-022594-fx044gcd	1261	5	up	up	NN
cord-022594-fx044gcd	1262	1	A	a	DT
cord-022594-fx044gcd	1262	2	longitudinal	longitudinal	JJ
cord-022594-fx044gcd	1262	3	study	study	NN
cord-022594-fx044gcd	1262	4	of	of	IN
cord-022594-fx044gcd	1262	5	abnormalities	abnormality	NNS
cord-022594-fx044gcd	1262	6	on	on	IN
cord-022594-fx044gcd	1262	7	MRI	MRI	NNP
cord-022594-fx044gcd	1262	8	and	and	CC
cord-022594-fx044gcd	1262	9	disability	disability	NN
cord-022594-fx044gcd	1262	10	from	from	IN
cord-022594-fx044gcd	1262	11	multiple	multiple	JJ
cord-022594-fx044gcd	1262	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1262	13	Occurrence	occurrence	NN
cord-022594-fx044gcd	1262	14	of	of	IN
cord-022594-fx044gcd	1262	15	a	a	DT
cord-022594-fx044gcd	1262	16	multiple	multiple	JJ
cord-022594-fx044gcd	1262	17	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1262	18	-	-	HYPH
cord-022594-fx044gcd	1262	19	like	like	JJ
cord-022594-fx044gcd	1262	20	illness	illness	NN
cord-022594-fx044gcd	1262	21	in	in	IN
cord-022594-fx044gcd	1262	22	women	woman	NNS
cord-022594-fx044gcd	1262	23	who	who	WP
cord-022594-fx044gcd	1262	24	have	have	VBP
cord-022594-fx044gcd	1262	25	a	a	DT
cord-022594-fx044gcd	1262	26	Leber	Leber	NNP
cord-022594-fx044gcd	1262	27	's	's	POS
cord-022594-fx044gcd	1262	28	hereditary	hereditary	JJ
cord-022594-fx044gcd	1262	29	optic	optic	JJ
cord-022594-fx044gcd	1262	30	neuropathy	neuropathy	NN
cord-022594-fx044gcd	1262	31	mitochondrial	mitochondrial	NN
cord-022594-fx044gcd	1262	32	DNA	DNA	NNP
cord-022594-fx044gcd	1262	33	mutation	mutation	NN
cord-022594-fx044gcd	1262	34	Genetic	genetic	JJ
cord-022594-fx044gcd	1262	35	disorders	disorder	NNS
cord-022594-fx044gcd	1262	36	that	that	WDT
cord-022594-fx044gcd	1262	37	masquerade	masquerade	VBP
cord-022594-fx044gcd	1262	38	as	as	IN
cord-022594-fx044gcd	1262	39	multiple	multiple	JJ
cord-022594-fx044gcd	1262	40	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1262	41	New	new	JJ
cord-022594-fx044gcd	1262	42	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	1262	43	criteria	criterion	NNS
cord-022594-fx044gcd	1262	44	for	for	IN
cord-022594-fx044gcd	1262	45	multiple	multiple	JJ
cord-022594-fx044gcd	1262	46	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1262	47	:	:	:
cord-022594-fx044gcd	1262	48	guidelines	guideline	NNS
cord-022594-fx044gcd	1262	49	for	for	IN
cord-022594-fx044gcd	1262	50	research	research	NN
cord-022594-fx044gcd	1262	51	protocols	protocol	NNS
cord-022594-fx044gcd	1263	1	Recommended	recommend	VBN
cord-022594-fx044gcd	1263	2	diagnostic	diagnostic	JJ
cord-022594-fx044gcd	1263	3	criteria	criterion	NNS
cord-022594-fx044gcd	1263	4	for	for	IN
cord-022594-fx044gcd	1263	5	multiple	multiple	JJ
cord-022594-fx044gcd	1263	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1263	7	:	:	:
cord-022594-fx044gcd	1263	8	Guidelines	guideline	NNS
cord-022594-fx044gcd	1263	9	from	from	IN
cord-022594-fx044gcd	1263	10	the	the	DT
cord-022594-fx044gcd	1263	11	International	International	NNP
cord-022594-fx044gcd	1263	12	Panel	Panel	NNP
cord-022594-fx044gcd	1263	13	on	on	IN
cord-022594-fx044gcd	1263	14	the	the	DT
cord-022594-fx044gcd	1263	15	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1263	16	of	of	IN
cord-022594-fx044gcd	1263	17	multiple	multiple	JJ
cord-022594-fx044gcd	1263	18	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1263	19	Assessment	Assessment	NNP
cord-022594-fx044gcd	1263	20	of	of	IN
cord-022594-fx044gcd	1263	21	MRI	MRI	NNP
cord-022594-fx044gcd	1263	22	criteria	criterion	NNS
cord-022594-fx044gcd	1263	23	for	for	IN
cord-022594-fx044gcd	1263	24	a	a	DT
cord-022594-fx044gcd	1263	25	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1263	26	of	of	IN
cord-022594-fx044gcd	1263	27	MS	MS	NNP
cord-022594-fx044gcd	1263	28	Neuroimaging	Neuroimaging	NNP
cord-022594-fx044gcd	1263	29	in	in	IN
cord-022594-fx044gcd	1263	30	multiple	multiple	JJ
cord-022594-fx044gcd	1263	31	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1264	1	The	the	DT
cord-022594-fx044gcd	1264	2	relationship	relationship	NN
cord-022594-fx044gcd	1264	3	between	between	IN
cord-022594-fx044gcd	1264	4	whole	whole	JJ
cord-022594-fx044gcd	1264	5	brain	brain	NN
cord-022594-fx044gcd	1264	6	volume	volume	NN
cord-022594-fx044gcd	1264	7	and	and	CC
cord-022594-fx044gcd	1264	8	disability	disability	NN
cord-022594-fx044gcd	1264	9	in	in	IN
cord-022594-fx044gcd	1264	10	multiple	multiple	JJ
cord-022594-fx044gcd	1264	11	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1264	12	:	:	:
cord-022594-fx044gcd	1264	13	a	a	DT
cord-022594-fx044gcd	1264	14	comparison	comparison	NN
cord-022594-fx044gcd	1264	15	of	of	IN
cord-022594-fx044gcd	1264	16	normalized	normalized	JJ
cord-022594-fx044gcd	1264	17	gray	gray	JJ
cord-022594-fx044gcd	1264	18	vs.	vs.	FW
cord-022594-fx044gcd	1264	19	white	white	JJ
cord-022594-fx044gcd	1264	20	matter	matter	NN
cord-022594-fx044gcd	1264	21	with	with	IN
cord-022594-fx044gcd	1264	22	misclassification	misclassification	NN
cord-022594-fx044gcd	1264	23	correction	correction	NN
cord-022594-fx044gcd	1264	24	Magnetization	magnetization	NN
cord-022594-fx044gcd	1264	25	transfer	transfer	NN
cord-022594-fx044gcd	1264	26	ratio	ratio	NN
cord-022594-fx044gcd	1264	27	histogram	histogram	NN
cord-022594-fx044gcd	1264	28	analysis	analysis	NN
cord-022594-fx044gcd	1264	29	of	of	IN
cord-022594-fx044gcd	1264	30	normal	normal	RB
cord-022594-fx044gcd	1264	31	-	-	HYPH
cord-022594-fx044gcd	1264	32	appearing	appear	VBG
cord-022594-fx044gcd	1264	33	gray	gray	JJ
cord-022594-fx044gcd	1264	34	matter	matter	NN
cord-022594-fx044gcd	1264	35	and	and	CC
cord-022594-fx044gcd	1264	36	normalappearing	normalappeare	VBG
cord-022594-fx044gcd	1264	37	white	white	JJ
cord-022594-fx044gcd	1264	38	matter	matter	NN
cord-022594-fx044gcd	1264	39	in	in	IN
cord-022594-fx044gcd	1264	40	multiple	multiple	JJ
cord-022594-fx044gcd	1264	41	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1264	42	MRI	MRI	NNP
cord-022594-fx044gcd	1264	43	T2	T2	NNP
cord-022594-fx044gcd	1264	44	hypointensity	hypointensity	NN
cord-022594-fx044gcd	1264	45	of	of	IN
cord-022594-fx044gcd	1264	46	the	the	DT
cord-022594-fx044gcd	1264	47	dentate	dentate	JJ
cord-022594-fx044gcd	1264	48	nucleus	nucleus	NN
cord-022594-fx044gcd	1264	49	is	be	VBZ
cord-022594-fx044gcd	1264	50	related	relate	VBN
cord-022594-fx044gcd	1264	51	to	to	IN
cord-022594-fx044gcd	1264	52	ambulatory	ambulatory	JJ
cord-022594-fx044gcd	1264	53	impairment	impairment	NN
cord-022594-fx044gcd	1264	54	in	in	IN
cord-022594-fx044gcd	1264	55	multiple	multiple	JJ
cord-022594-fx044gcd	1264	56	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1264	57	Evidence	evidence	NN
cord-022594-fx044gcd	1264	58	of	of	IN
cord-022594-fx044gcd	1264	59	early	early	JJ
cord-022594-fx044gcd	1264	60	cortical	cortical	JJ
cord-022594-fx044gcd	1264	61	atrophy	atrophy	NN
cord-022594-fx044gcd	1264	62	in	in	IN
cord-022594-fx044gcd	1264	63	MS	MS	NNP
cord-022594-fx044gcd	1264	64	:	:	:
cord-022594-fx044gcd	1264	65	Relevance	relevance	NN
cord-022594-fx044gcd	1264	66	to	to	IN
cord-022594-fx044gcd	1264	67	white	white	JJ
cord-022594-fx044gcd	1264	68	matter	matter	NN
cord-022594-fx044gcd	1264	69	changes	change	NNS
cord-022594-fx044gcd	1264	70	and	and	CC
cord-022594-fx044gcd	1264	71	disability	disability	NN
cord-022594-fx044gcd	1264	72	CSF	csf	NN
cord-022594-fx044gcd	1264	73	electrophoresis	electrophoresis	NN
cord-022594-fx044gcd	1264	74	in	in	IN
cord-022594-fx044gcd	1264	75	one	one	CD
cord-022594-fx044gcd	1264	76	thousand	thousand	CD
cord-022594-fx044gcd	1264	77	patients	patient	NNS
cord-022594-fx044gcd	1265	1	Early	early	JJ
cord-022594-fx044gcd	1265	2	differential	differential	JJ
cord-022594-fx044gcd	1265	3	diagnosis	diagnosis	NN
cord-022594-fx044gcd	1265	4	of	of	IN
cord-022594-fx044gcd	1265	5	multiple	multiple	JJ
cord-022594-fx044gcd	1265	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1265	7	using	use	VBG
cord-022594-fx044gcd	1265	8	a	a	DT
cord-022594-fx044gcd	1265	9	new	new	JJ
cord-022594-fx044gcd	1265	10	oligoclonal	oligoclonal	JJ
cord-022594-fx044gcd	1265	11	band	band	NN
cord-022594-fx044gcd	1265	12	test	test	NN
cord-022594-fx044gcd	1265	13	Diagnostic	diagnostic	JJ
cord-022594-fx044gcd	1265	14	criteria	criterion	NNS
cord-022594-fx044gcd	1265	15	for	for	IN
cord-022594-fx044gcd	1265	16	multiple	multiple	JJ
cord-022594-fx044gcd	1265	17	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1265	18	:	:	:
cord-022594-fx044gcd	1266	1	2005	2005	CD
cord-022594-fx044gcd	1266	2	revisions	revision	NNS
cord-022594-fx044gcd	1266	3	to	to	IN
cord-022594-fx044gcd	1266	4	the	the	DT
cord-022594-fx044gcd	1266	5	"	"	``
cord-022594-fx044gcd	1266	6	McDonald	McDonald	NNP
cord-022594-fx044gcd	1266	7	Criteria	Criteria	NNP
cord-022594-fx044gcd	1267	1	The	the	DT
cord-022594-fx044gcd	1267	2	optic	optic	JJ
cord-022594-fx044gcd	1267	3	neuritis	neuritis	NN
cord-022594-fx044gcd	1267	4	treatment	treatment	NN
cord-022594-fx044gcd	1267	5	trial	trial	NN
cord-022594-fx044gcd	1267	6	:	:	:
cord-022594-fx044gcd	1267	7	three	three	CD
cord-022594-fx044gcd	1267	8	-	-	HYPH
cord-022594-fx044gcd	1267	9	year	year	NN
cord-022594-fx044gcd	1267	10	follow	follow	NN
cord-022594-fx044gcd	1267	11	-	-	HYPH
cord-022594-fx044gcd	1267	12	up	up	RP
cord-022594-fx044gcd	1267	13	results	result	NNS
cord-022594-fx044gcd	1267	14	Effects	effect	NNS
cord-022594-fx044gcd	1267	15	of	of	IN
cord-022594-fx044gcd	1267	16	IV	IV	NNP
cord-022594-fx044gcd	1267	17	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	1267	18	on	on	IN
cord-022594-fx044gcd	1267	19	brain	brain	NN
cord-022594-fx044gcd	1267	20	atrophy	atrophy	NN
cord-022594-fx044gcd	1267	21	in	in	IN
cord-022594-fx044gcd	1267	22	relapsing	relapse	VBG
cord-022594-fx044gcd	1267	23	-	-	HYPH
cord-022594-fx044gcd	1267	24	remitting	remit	VBG
cord-022594-fx044gcd	1267	25	MS	MS	NNP
cord-022594-fx044gcd	1267	26	Double	double	JJ
cord-022594-fx044gcd	1267	27	-	-	HYPH
cord-022594-fx044gcd	1267	28	blind	blind	JJ
cord-022594-fx044gcd	1267	29	study	study	NN
cord-022594-fx044gcd	1267	30	of	of	IN
cord-022594-fx044gcd	1267	31	true	true	JJ
cord-022594-fx044gcd	1267	32	vs.	vs.	FW
cord-022594-fx044gcd	1267	33	sham	sham	JJ
cord-022594-fx044gcd	1267	34	plasma	plasma	NN
cord-022594-fx044gcd	1267	35	exchange	exchange	NN
cord-022594-fx044gcd	1267	36	in	in	IN
cord-022594-fx044gcd	1267	37	patients	patient	NNS
cord-022594-fx044gcd	1267	38	treated	treat	VBN
cord-022594-fx044gcd	1267	39	with	with	IN
cord-022594-fx044gcd	1267	40	immunosuppression	immunosuppression	NN
cord-022594-fx044gcd	1267	41	for	for	IN
cord-022594-fx044gcd	1267	42	acute	acute	JJ
cord-022594-fx044gcd	1267	43	attacks	attack	NNS
cord-022594-fx044gcd	1267	44	of	of	IN
cord-022594-fx044gcd	1267	45	multiple	multiple	JJ
cord-022594-fx044gcd	1267	46	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1267	47	Plasmapheresis	Plasmapheresis	NNP
cord-022594-fx044gcd	1267	48	in	in	IN
cord-022594-fx044gcd	1267	49	acute	acute	JJ
cord-022594-fx044gcd	1267	50	episodes	episode	NNS
cord-022594-fx044gcd	1267	51	of	of	IN
cord-022594-fx044gcd	1267	52	fulminant	fulminant	JJ
cord-022594-fx044gcd	1267	53	CNS	CNS	NNP
cord-022594-fx044gcd	1267	54	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1267	55	demyelination	demyelination	NN
cord-022594-fx044gcd	1268	1	A	a	DT
cord-022594-fx044gcd	1268	2	randomized	randomized	JJ
cord-022594-fx044gcd	1268	3	trial	trial	NN
cord-022594-fx044gcd	1268	4	of	of	IN
cord-022594-fx044gcd	1268	5	plasma	plasma	NN
cord-022594-fx044gcd	1268	6	exchange	exchange	NN
cord-022594-fx044gcd	1268	7	in	in	IN
cord-022594-fx044gcd	1268	8	acute	acute	JJ
cord-022594-fx044gcd	1268	9	central	central	JJ
cord-022594-fx044gcd	1268	10	nervous	nervous	JJ
cord-022594-fx044gcd	1268	11	system	system	NN
cord-022594-fx044gcd	1268	12	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1268	13	demyelinating	demyelinate	VBG
cord-022594-fx044gcd	1268	14	disease	disease	NN
cord-022594-fx044gcd	1268	15	Relation	relation	NN
cord-022594-fx044gcd	1268	16	between	between	IN
cord-022594-fx044gcd	1268	17	humoral	humoral	JJ
cord-022594-fx044gcd	1268	18	pathological	pathological	JJ
cord-022594-fx044gcd	1268	19	changes	change	NNS
cord-022594-fx044gcd	1268	20	in	in	IN
cord-022594-fx044gcd	1268	21	multiple	multiple	JJ
cord-022594-fx044gcd	1268	22	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1268	23	and	and	CC
cord-022594-fx044gcd	1268	24	response	response	NN
cord-022594-fx044gcd	1268	25	to	to	IN
cord-022594-fx044gcd	1268	26	therapeutic	therapeutic	JJ
cord-022594-fx044gcd	1268	27	plasma	plasma	NN
cord-022594-fx044gcd	1268	28	exchange	exchange	NNP
cord-022594-fx044gcd	1268	29	Plasma	Plasma	NNP
cord-022594-fx044gcd	1268	30	exchange	exchange	NN
cord-022594-fx044gcd	1268	31	for	for	IN
cord-022594-fx044gcd	1268	32	severe	severe	JJ
cord-022594-fx044gcd	1268	33	attacks	attack	NNS
cord-022594-fx044gcd	1268	34	of	of	IN
cord-022594-fx044gcd	1268	35	CNS	CNS	NNP
cord-022594-fx044gcd	1268	36	demyelination	demyelination	NN
cord-022594-fx044gcd	1268	37	:	:	:
cord-022594-fx044gcd	1268	38	predictors	predictor	NNS
cord-022594-fx044gcd	1268	39	of	of	IN
cord-022594-fx044gcd	1268	40	response	response	NN
cord-022594-fx044gcd	1269	1	Intramuscular	intramuscular	JJ
cord-022594-fx044gcd	1269	2	interferon	interferon	NN
cord-022594-fx044gcd	1269	3	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1269	4	therapy	therapy	NN
cord-022594-fx044gcd	1269	5	initiated	initiate	VBD
cord-022594-fx044gcd	1269	6	during	during	IN
cord-022594-fx044gcd	1269	7	a	a	DT
cord-022594-fx044gcd	1269	8	first	first	JJ
cord-022594-fx044gcd	1269	9	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1269	10	event	event	NN
cord-022594-fx044gcd	1269	11	in	in	IN
cord-022594-fx044gcd	1269	12	multiple	multiple	JJ
cord-022594-fx044gcd	1269	13	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1269	14	.	.	.
cord-022594-fx044gcd	1270	1	CHAMPS	CHAMPS	NNP
cord-022594-fx044gcd	1270	2	Study	Study	NNP
cord-022594-fx044gcd	1270	3	Group	Group	NNP
cord-022594-fx044gcd	1271	1	Interferon	Interferon	NNP
cord-022594-fx044gcd	1271	2	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1271	3	for	for	IN
cord-022594-fx044gcd	1271	4	early	early	JJ
cord-022594-fx044gcd	1271	5	multiple	multiple	JJ
cord-022594-fx044gcd	1271	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1271	7	:	:	:
cord-022594-fx044gcd	1271	8	CHAMPS	CHAMPS	NNP
cord-022594-fx044gcd	1271	9	trial	trial	NN
cord-022594-fx044gcd	1271	10	subgroup	subgroup	NN
cord-022594-fx044gcd	1271	11	analyses	analysis	NNS
cord-022594-fx044gcd	1271	12	Effect	Effect	NNP
cord-022594-fx044gcd	1271	13	of	of	IN
cord-022594-fx044gcd	1271	14	early	early	JJ
cord-022594-fx044gcd	1271	15	interferon	interferon	NN
cord-022594-fx044gcd	1271	16	treatment	treatment	NN
cord-022594-fx044gcd	1271	17	on	on	IN
cord-022594-fx044gcd	1271	18	conversion	conversion	NN
cord-022594-fx044gcd	1271	19	to	to	IN
cord-022594-fx044gcd	1271	20	definite	definite	JJ
cord-022594-fx044gcd	1271	21	multiple	multiple	JJ
cord-022594-fx044gcd	1271	22	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1271	23	:	:	:
cord-022594-fx044gcd	1272	1	A	a	DT
cord-022594-fx044gcd	1272	2	randomised	randomised	JJ
cord-022594-fx044gcd	1272	3	study	study	NN
cord-022594-fx044gcd	1273	1	Interferon	Interferon	NNP
cord-022594-fx044gcd	1273	2	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1273	3	is	be	VBZ
cord-022594-fx044gcd	1273	4	effective	effective	JJ
cord-022594-fx044gcd	1273	5	in	in	IN
cord-022594-fx044gcd	1273	6	relapsing	relapse	VBG
cord-022594-fx044gcd	1273	7	-	-	HYPH
cord-022594-fx044gcd	1273	8	remitting	remit	VBG
cord-022594-fx044gcd	1273	9	multiple	multiple	JJ
cord-022594-fx044gcd	1273	10	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1273	11	.	.	.
cord-022594-fx044gcd	1274	1	I.	i.	LS
cord-022594-fx044gcd	1274	2	Clinical	clinical	JJ
cord-022594-fx044gcd	1274	3	results	result	NNS
cord-022594-fx044gcd	1274	4	of	of	IN
cord-022594-fx044gcd	1274	5	a	a	DT
cord-022594-fx044gcd	1274	6	multicenter	multicenter	NN
cord-022594-fx044gcd	1274	7	,	,	,
cord-022594-fx044gcd	1274	8	randomized	randomized	JJ
cord-022594-fx044gcd	1274	9	,	,	,
cord-022594-fx044gcd	1274	10	double	double	JJ
cord-022594-fx044gcd	1274	11	-	-	HYPH
cord-022594-fx044gcd	1274	12	blind	blind	JJ
cord-022594-fx044gcd	1274	13	,	,	,
cord-022594-fx044gcd	1274	14	placebo	placebo	NN
cord-022594-fx044gcd	1274	15	-	-	HYPH
cord-022594-fx044gcd	1274	16	controlled	control	VBN
cord-022594-fx044gcd	1274	17	trial	trial	NN
cord-022594-fx044gcd	1274	18	.	.	.
cord-022594-fx044gcd	1275	1	The	the	DT
cord-022594-fx044gcd	1275	2	IFNB	IFNB	NNP
cord-022594-fx044gcd	1275	3	Multiple	Multiple	NNP
cord-022594-fx044gcd	1275	4	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1275	5	Study	Study	NNP
cord-022594-fx044gcd	1275	6	Group	Group	NNP
cord-022594-fx044gcd	1275	7	Further	Further	NNP
cord-022594-fx044gcd	1275	8	study	study	NN
cord-022594-fx044gcd	1275	9	on	on	IN
cord-022594-fx044gcd	1275	10	the	the	DT
cord-022594-fx044gcd	1275	11	specificity	specificity	NN
cord-022594-fx044gcd	1275	12	and	and	CC
cord-022594-fx044gcd	1275	13	incidence	incidence	NN
cord-022594-fx044gcd	1275	14	of	of	IN
cord-022594-fx044gcd	1275	15	neutralizing	neutralize	VBG
cord-022594-fx044gcd	1275	16	antibodies	antibody	NNS
cord-022594-fx044gcd	1275	17	to	to	IN
cord-022594-fx044gcd	1275	18	interferon	interferon	NN
cord-022594-fx044gcd	1275	19	(	(	-LRB-
cord-022594-fx044gcd	1275	20	IFN	IFN	NNP
cord-022594-fx044gcd	1275	21	)	)	-RRB-
cord-022594-fx044gcd	1275	22	in	in	IN
cord-022594-fx044gcd	1275	23	relapsing	relapse	VBG
cord-022594-fx044gcd	1275	24	remitting	remit	VBG
cord-022594-fx044gcd	1275	25	multiple	multiple	JJ
cord-022594-fx044gcd	1275	26	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1275	27	patients	patient	NNS
cord-022594-fx044gcd	1275	28	treated	treat	VBN
cord-022594-fx044gcd	1275	29	with	with	IN
cord-022594-fx044gcd	1275	30	IFN	IFN	NNP
cord-022594-fx044gcd	1275	31	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1275	32	or	or	CC
cord-022594-fx044gcd	1275	33	IFN	IFN	NNP
cord-022594-fx044gcd	1275	34	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1275	35	Intramuscular	intramuscular	JJ
cord-022594-fx044gcd	1275	36	interferon	interferon	NN
cord-022594-fx044gcd	1275	37	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1275	38	for	for	IN
cord-022594-fx044gcd	1275	39	disease	disease	NN
cord-022594-fx044gcd	1275	40	progression	progression	NN
cord-022594-fx044gcd	1275	41	in	in	IN
cord-022594-fx044gcd	1275	42	relapsing	relapse	VBG
cord-022594-fx044gcd	1275	43	multiple	multiple	JJ
cord-022594-fx044gcd	1275	44	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1275	45	.	.	.
cord-022594-fx044gcd	1276	1	The	the	DT
cord-022594-fx044gcd	1276	2	Multiple	Multiple	NNP
cord-022594-fx044gcd	1276	3	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1276	4	Collaborative	Collaborative	NNP
cord-022594-fx044gcd	1276	5	Research	Research	NNP
cord-022594-fx044gcd	1276	6	Group	Group	NNP
cord-022594-fx044gcd	1276	7	(	(	-LRB-
cord-022594-fx044gcd	1276	8	MSCRG	MSCRG	NNP
cord-022594-fx044gcd	1276	9	)	)	-RRB-
cord-022594-fx044gcd	1277	1	The	the	DT
cord-022594-fx044gcd	1277	2	long	long	JJ
cord-022594-fx044gcd	1277	3	-	-	HYPH
cord-022594-fx044gcd	1277	4	term	term	NN
cord-022594-fx044gcd	1277	5	safety	safety	NN
cord-022594-fx044gcd	1277	6	and	and	CC
cord-022594-fx044gcd	1277	7	tolerability	tolerability	NN
cord-022594-fx044gcd	1277	8	of	of	IN
cord-022594-fx044gcd	1277	9	high	high	JJ
cord-022594-fx044gcd	1277	10	-	-	HYPH
cord-022594-fx044gcd	1277	11	dose	dose	NN
cord-022594-fx044gcd	1277	12	interferon	interferon	NN
cord-022594-fx044gcd	1277	13	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1277	14	in	in	IN
cord-022594-fx044gcd	1277	15	relapsing	relapse	VBG
cord-022594-fx044gcd	1277	16	-	-	HYPH
cord-022594-fx044gcd	1277	17	remitting	remit	VBG
cord-022594-fx044gcd	1277	18	multiple	multiple	JJ
cord-022594-fx044gcd	1277	19	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1277	20	:	:	:
cord-022594-fx044gcd	1277	21	4-year	4-year	JJ
cord-022594-fx044gcd	1277	22	data	datum	NNS
cord-022594-fx044gcd	1277	23	from	from	IN
cord-022594-fx044gcd	1277	24	the	the	DT
cord-022594-fx044gcd	1277	25	PRISMS	PRISMS	NNP
cord-022594-fx044gcd	1277	26	study	study	NN
cord-022594-fx044gcd	1278	1	Randomised	randomised	JJ
cord-022594-fx044gcd	1278	2	double	double	JJ
cord-022594-fx044gcd	1278	3	-	-	HYPH
cord-022594-fx044gcd	1278	4	blind	blind	JJ
cord-022594-fx044gcd	1278	5	placebo	placebo	NN
cord-022594-fx044gcd	1278	6	-	-	HYPH
cord-022594-fx044gcd	1278	7	controlled	control	VBN
cord-022594-fx044gcd	1278	8	study	study	NN
cord-022594-fx044gcd	1278	9	of	of	IN
cord-022594-fx044gcd	1278	10	interferon	interferon	NNP
cord-022594-fx044gcd	1278	11	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1278	12	in	in	IN
cord-022594-fx044gcd	1278	13	relapsing	relapse	VBG
cord-022594-fx044gcd	1278	14	/	/	SYM
cord-022594-fx044gcd	1278	15	remitting	remit	VBG
cord-022594-fx044gcd	1278	16	multiple	multiple	JJ
cord-022594-fx044gcd	1278	17	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1278	18	.	.	.
cord-022594-fx044gcd	1279	1	PRISMS	PRISMS	NNP
cord-022594-fx044gcd	1279	2	(	(	-LRB-
cord-022594-fx044gcd	1279	3	Prevention	Prevention	NNP
cord-022594-fx044gcd	1279	4	of	of	IN
cord-022594-fx044gcd	1279	5	Relapses	Relapses	NNPS
cord-022594-fx044gcd	1279	6	and	and	CC
cord-022594-fx044gcd	1279	7	Disability	Disability	NNP
cord-022594-fx044gcd	1279	8	by	by	IN
cord-022594-fx044gcd	1279	9	Interferon	Interferon	NNP
cord-022594-fx044gcd	1279	10	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1279	11	Subcutaneously	Subcutaneously	NNP
cord-022594-fx044gcd	1279	12	in	in	IN
cord-022594-fx044gcd	1279	13	Multiple	Multiple	NNP
cord-022594-fx044gcd	1279	14	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1279	15	)	)	-RRB-
cord-022594-fx044gcd	1280	1	Study	Study	NNP
cord-022594-fx044gcd	1280	2	Group	Group	NNP
cord-022594-fx044gcd	1280	3	Magnetic	Magnetic	NNP
cord-022594-fx044gcd	1280	4	resonance	resonance	NN
cord-022594-fx044gcd	1280	5	imaging	imaging	NN
cord-022594-fx044gcd	1280	6	results	result	NNS
cord-022594-fx044gcd	1280	7	of	of	IN
cord-022594-fx044gcd	1280	8	the	the	DT
cord-022594-fx044gcd	1280	9	PRISMS	PRISMS	NNP
cord-022594-fx044gcd	1280	10	trial	trial	NN
cord-022594-fx044gcd	1280	11	:	:	:
cord-022594-fx044gcd	1280	12	A	a	DT
cord-022594-fx044gcd	1280	13	randomized	randomized	JJ
cord-022594-fx044gcd	1280	14	,	,	,
cord-022594-fx044gcd	1280	15	double	double	JJ
cord-022594-fx044gcd	1280	16	-	-	HYPH
cord-022594-fx044gcd	1280	17	blind	blind	JJ
cord-022594-fx044gcd	1280	18	,	,	,
cord-022594-fx044gcd	1280	19	placebo	placebo	NN
cord-022594-fx044gcd	1280	20	-	-	HYPH
cord-022594-fx044gcd	1280	21	controlled	control	VBN
cord-022594-fx044gcd	1280	22	study	study	NN
cord-022594-fx044gcd	1280	23	of	of	IN
cord-022594-fx044gcd	1280	24	interferon	interferon	NN
cord-022594-fx044gcd	1280	25	-	-	HYPH
cord-022594-fx044gcd	1280	26	beta1a	beta1a	NNP
cord-022594-fx044gcd	1280	27	in	in	IN
cord-022594-fx044gcd	1280	28	relapsing	relapse	VBG
cord-022594-fx044gcd	1280	29	-	-	HYPH
cord-022594-fx044gcd	1280	30	remitting	remit	VBG
cord-022594-fx044gcd	1280	31	multiple	multiple	JJ
cord-022594-fx044gcd	1280	32	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1280	33	.	.	.
cord-022594-fx044gcd	1281	1	Prevention	prevention	NN
cord-022594-fx044gcd	1281	2	of	of	IN
cord-022594-fx044gcd	1281	3	Relapses	Relapses	NNPS
cord-022594-fx044gcd	1281	4	and	and	CC
cord-022594-fx044gcd	1281	5	Disability	Disability	NNP
cord-022594-fx044gcd	1281	6	by	by	IN
cord-022594-fx044gcd	1282	1	Interferon	Interferon	NNP
cord-022594-fx044gcd	1282	2	-	-	HYPH
cord-022594-fx044gcd	1282	3	beta1a	beta1a	NNP
cord-022594-fx044gcd	1282	4	Subcutaneously	Subcutaneously	NNP
cord-022594-fx044gcd	1282	5	in	in	IN
cord-022594-fx044gcd	1282	6	Multiple	Multiple	NNP
cord-022594-fx044gcd	1282	7	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1282	8	Ingested	Ingested	NNP
cord-022594-fx044gcd	1282	9	IFN	IFN	NNP
cord-022594-fx044gcd	1282	10	-	-	HYPH
cord-022594-fx044gcd	1282	11	alpha	alpha	NN
cord-022594-fx044gcd	1282	12	:	:	:
cord-022594-fx044gcd	1283	1	results	result	NNS
cord-022594-fx044gcd	1283	2	of	of	IN
cord-022594-fx044gcd	1283	3	a	a	DT
cord-022594-fx044gcd	1283	4	pilot	pilot	NN
cord-022594-fx044gcd	1283	5	study	study	NN
cord-022594-fx044gcd	1283	6	in	in	IN
cord-022594-fx044gcd	1283	7	relapsing	relapse	VBG
cord-022594-fx044gcd	1283	8	-	-	HYPH
cord-022594-fx044gcd	1283	9	remitting	remit	VBG
cord-022594-fx044gcd	1283	10	MS	MS	NNP
cord-022594-fx044gcd	1283	11	Clinical	clinical	JJ
cord-022594-fx044gcd	1283	12	characteristics	characteristic	NNS
cord-022594-fx044gcd	1283	13	of	of	IN
cord-022594-fx044gcd	1283	14	responders	responder	NNS
cord-022594-fx044gcd	1283	15	to	to	IN
cord-022594-fx044gcd	1283	16	interferon	interferon	NN
cord-022594-fx044gcd	1283	17	therapy	therapy	NN
cord-022594-fx044gcd	1283	18	for	for	IN
cord-022594-fx044gcd	1283	19	relapsing	relapse	VBG
cord-022594-fx044gcd	1283	20	MS	MS	NNP
cord-022594-fx044gcd	1283	21	A	a	DT
cord-022594-fx044gcd	1283	22	pilot	pilot	NN
cord-022594-fx044gcd	1283	23	trial	trial	NN
cord-022594-fx044gcd	1283	24	of	of	IN
cord-022594-fx044gcd	1283	25	Cop	cop	NN
cord-022594-fx044gcd	1283	26	1	1	CD
cord-022594-fx044gcd	1283	27	in	in	IN
cord-022594-fx044gcd	1283	28	exacerbating	exacerbate	VBG
cord-022594-fx044gcd	1283	29	-	-	HYPH
cord-022594-fx044gcd	1283	30	remitting	remit	VBG
cord-022594-fx044gcd	1283	31	multiple	multiple	JJ
cord-022594-fx044gcd	1283	32	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1284	1	Copolymer	copolymer	NN
cord-022594-fx044gcd	1284	2	1	1	CD
cord-022594-fx044gcd	1284	3	reduces	reduce	VBZ
cord-022594-fx044gcd	1284	4	relapse	relapse	NN
cord-022594-fx044gcd	1284	5	rate	rate	NN
cord-022594-fx044gcd	1284	6	and	and	CC
cord-022594-fx044gcd	1284	7	improves	improve	VBZ
cord-022594-fx044gcd	1284	8	disability	disability	NN
cord-022594-fx044gcd	1284	9	in	in	IN
cord-022594-fx044gcd	1284	10	relapsing	relapse	VBG
cord-022594-fx044gcd	1284	11	-	-	HYPH
cord-022594-fx044gcd	1284	12	remitting	remit	VBG
cord-022594-fx044gcd	1284	13	multiple	multiple	JJ
cord-022594-fx044gcd	1284	14	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1284	15	:	:	:
cord-022594-fx044gcd	1285	1	Results	result	NNS
cord-022594-fx044gcd	1285	2	of	of	IN
cord-022594-fx044gcd	1285	3	a	a	DT
cord-022594-fx044gcd	1285	4	phase	phase	NN
cord-022594-fx044gcd	1285	5	III	iii	CD
cord-022594-fx044gcd	1285	6	multicenter	multicenter	JJ
cord-022594-fx044gcd	1285	7	,	,	,
cord-022594-fx044gcd	1285	8	double	double	JJ
cord-022594-fx044gcd	1285	9	-	-	HYPH
cord-022594-fx044gcd	1285	10	blind	blind	JJ
cord-022594-fx044gcd	1285	11	placebocontrolled	placebocontrolled	JJ
cord-022594-fx044gcd	1285	12	trial	trial	NN
cord-022594-fx044gcd	1285	13	.	.	.
cord-022594-fx044gcd	1286	1	The	the	DT
cord-022594-fx044gcd	1286	2	Copolymer	Copolymer	NNP
cord-022594-fx044gcd	1286	3	1	1	CD
cord-022594-fx044gcd	1286	4	Multiple	Multiple	NNP
cord-022594-fx044gcd	1286	5	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1286	6	Study	Study	NNP
cord-022594-fx044gcd	1286	7	Group	Group	NNP
cord-022594-fx044gcd	1286	8	Glatiramer	Glatiramer	NNP
cord-022594-fx044gcd	1286	9	acetate	acetate	NN
cord-022594-fx044gcd	1286	10	reduces	reduce	VBZ
cord-022594-fx044gcd	1286	11	the	the	DT
cord-022594-fx044gcd	1286	12	proportion	proportion	NN
cord-022594-fx044gcd	1286	13	of	of	IN
cord-022594-fx044gcd	1286	14	new	new	JJ
cord-022594-fx044gcd	1286	15	MS	MS	NNP
cord-022594-fx044gcd	1286	16	lesions	lesion	NNS
cord-022594-fx044gcd	1286	17	evolving	evolve	VBG
cord-022594-fx044gcd	1286	18	into	into	IN
cord-022594-fx044gcd	1286	19	"	"	``
cord-022594-fx044gcd	1286	20	black	black	JJ
cord-022594-fx044gcd	1286	21	holes	hole	NNS
cord-022594-fx044gcd	1286	22	European	european	JJ
cord-022594-fx044gcd	1286	23	/	/	SYM
cord-022594-fx044gcd	1286	24	Canadian	canadian	JJ
cord-022594-fx044gcd	1286	25	multicenter	multicenter	NN
cord-022594-fx044gcd	1286	26	,	,	,
cord-022594-fx044gcd	1286	27	double	double	JJ
cord-022594-fx044gcd	1286	28	-	-	HYPH
cord-022594-fx044gcd	1286	29	blind	blind	JJ
cord-022594-fx044gcd	1286	30	,	,	,
cord-022594-fx044gcd	1286	31	randomized	randomized	JJ
cord-022594-fx044gcd	1286	32	,	,	,
cord-022594-fx044gcd	1286	33	placebo	placebo	NN
cord-022594-fx044gcd	1286	34	-	-	HYPH
cord-022594-fx044gcd	1286	35	controlled	control	VBN
cord-022594-fx044gcd	1286	36	study	study	NN
cord-022594-fx044gcd	1286	37	of	of	IN
cord-022594-fx044gcd	1286	38	the	the	DT
cord-022594-fx044gcd	1286	39	effects	effect	NNS
cord-022594-fx044gcd	1286	40	of	of	IN
cord-022594-fx044gcd	1286	41	glatiramer	glatiramer	NN
cord-022594-fx044gcd	1286	42	acetate	acetate	NN
cord-022594-fx044gcd	1286	43	on	on	IN
cord-022594-fx044gcd	1286	44	magnetic	magnetic	JJ
cord-022594-fx044gcd	1286	45	resonance	resonance	NN
cord-022594-fx044gcd	1286	46	imaging	imaging	NN
cord-022594-fx044gcd	1286	47	-	-	HYPH
cord-022594-fx044gcd	1286	48	measured	measure	VBN
cord-022594-fx044gcd	1286	49	disease	disease	NN
cord-022594-fx044gcd	1286	50	activity	activity	NN
cord-022594-fx044gcd	1286	51	and	and	CC
cord-022594-fx044gcd	1286	52	burden	burden	NN
cord-022594-fx044gcd	1286	53	in	in	IN
cord-022594-fx044gcd	1286	54	patients	patient	NNS
cord-022594-fx044gcd	1286	55	with	with	IN
cord-022594-fx044gcd	1286	56	relapsing	relapse	VBG
cord-022594-fx044gcd	1286	57	multiple	multiple	JJ
cord-022594-fx044gcd	1286	58	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1286	59	.	.	.
cord-022594-fx044gcd	1287	1	European	european	JJ
cord-022594-fx044gcd	1287	2	/	/	SYM
cord-022594-fx044gcd	1287	3	Canadian	Canadian	NNP
cord-022594-fx044gcd	1287	4	Glatiramer	Glatiramer	NNP
cord-022594-fx044gcd	1287	5	Acetate	Acetate	NNP
cord-022594-fx044gcd	1287	6	Study	Study	NNP
cord-022594-fx044gcd	1287	7	Group	Group	NNP
cord-022594-fx044gcd	1287	8	United	United	NNP
cord-022594-fx044gcd	1287	9	States	States	NNP
cord-022594-fx044gcd	1287	10	open	open	JJ
cord-022594-fx044gcd	1287	11	-	-	HYPH
cord-022594-fx044gcd	1287	12	label	label	NN
cord-022594-fx044gcd	1287	13	glatiramer	glatiramer	NNP
cord-022594-fx044gcd	1287	14	acetate	acetate	NN
cord-022594-fx044gcd	1287	15	extension	extension	NN
cord-022594-fx044gcd	1287	16	trial	trial	NN
cord-022594-fx044gcd	1287	17	for	for	IN
cord-022594-fx044gcd	1287	18	relapsing	relapse	VBG
cord-022594-fx044gcd	1287	19	multiple	multiple	JJ
cord-022594-fx044gcd	1287	20	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1287	21	:	:	:
cord-022594-fx044gcd	1287	22	MRI	MRI	NNP
cord-022594-fx044gcd	1287	23	and	and	CC
cord-022594-fx044gcd	1287	24	clinical	clinical	JJ
cord-022594-fx044gcd	1287	25	correlates	correlate	NNS
cord-022594-fx044gcd	1287	26	.	.	.
cord-022594-fx044gcd	1288	1	Multiple	Multiple	NNP
cord-022594-fx044gcd	1288	2	Sclerosis	Sclerosis	NNP
cord-022594-fx044gcd	1288	3	Study	Study	NNP
cord-022594-fx044gcd	1288	4	Group	Group	NNP
cord-022594-fx044gcd	1288	5	and	and	CC
cord-022594-fx044gcd	1288	6	the	the	DT
cord-022594-fx044gcd	1288	7	MRI	MRI	NNP
cord-022594-fx044gcd	1288	8	Analysis	Analysis	NNP
cord-022594-fx044gcd	1288	9	Center	Center	NNP
cord-022594-fx044gcd	1288	10	Longitudinal	Longitudinal	NNP
cord-022594-fx044gcd	1288	11	MRI	MRI	NNP
cord-022594-fx044gcd	1288	12	study	study	NN
cord-022594-fx044gcd	1288	13	:	:	:
cord-022594-fx044gcd	1288	14	The	the	DT
cord-022594-fx044gcd	1288	15	effects	effect	NNS
cord-022594-fx044gcd	1288	16	of	of	IN
cord-022594-fx044gcd	1288	17	azathioprine	azathioprine	NN
cord-022594-fx044gcd	1288	18	in	in	IN
cord-022594-fx044gcd	1288	19	MS	MS	NNP
cord-022594-fx044gcd	1288	20	patients	patient	NNS
cord-022594-fx044gcd	1288	21	refractory	refractory	JJ
cord-022594-fx044gcd	1288	22	to	to	IN
cord-022594-fx044gcd	1288	23	interferon	interferon	NN
cord-022594-fx044gcd	1289	1	beta-1b	beta-1b	NNS
cord-022594-fx044gcd	1290	1	The	the	DT
cord-022594-fx044gcd	1290	2	Austrian	austrian	JJ
cord-022594-fx044gcd	1290	3	Immunoglobulin	Immunoglobulin	NNP
cord-022594-fx044gcd	1290	4	in	in	IN
cord-022594-fx044gcd	1290	5	MS	MS	NNP
cord-022594-fx044gcd	1290	6	(	(	-LRB-
cord-022594-fx044gcd	1290	7	AIMS	aim	VBZ
cord-022594-fx044gcd	1290	8	)	)	-RRB-
cord-022594-fx044gcd	1290	9	study	study	NN
cord-022594-fx044gcd	1290	10	:	:	:
cord-022594-fx044gcd	1290	11	final	final	JJ
cord-022594-fx044gcd	1290	12	analysis	analysis	NN
cord-022594-fx044gcd	1291	1	A	a	DT
cord-022594-fx044gcd	1291	2	randomized	randomized	JJ
cord-022594-fx044gcd	1291	3	trial	trial	NN
cord-022594-fx044gcd	1291	4	of	of	IN
cord-022594-fx044gcd	1291	5	intravenous	intravenous	JJ
cord-022594-fx044gcd	1291	6	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	1291	7	in	in	IN
cord-022594-fx044gcd	1291	8	inflammatory	inflammatory	JJ
cord-022594-fx044gcd	1291	9	demyelinating	demyelinating	JJ
cord-022594-fx044gcd	1291	10	optic	optic	JJ
cord-022594-fx044gcd	1291	11	neuritis	neuritis	NN
cord-022594-fx044gcd	1291	12	IV	IV	NNP
cord-022594-fx044gcd	1291	13	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	1291	14	does	do	VBZ
cord-022594-fx044gcd	1291	15	not	not	RB
cord-022594-fx044gcd	1291	16	reverse	reverse	VB
cord-022594-fx044gcd	1291	17	established	establish	VBN
cord-022594-fx044gcd	1291	18	weakness	weakness	NN
cord-022594-fx044gcd	1291	19	in	in	IN
cord-022594-fx044gcd	1291	20	MS	MS	NNP
cord-022594-fx044gcd	1291	21	Placebo	Placebo	NNP
cord-022594-fx044gcd	1291	22	controlled	control	VBD
cord-022594-fx044gcd	1291	23	pilot	pilot	NN
cord-022594-fx044gcd	1291	24	trial	trial	NN
cord-022594-fx044gcd	1291	25	to	to	TO
cord-022594-fx044gcd	1291	26	study	study	VB
cord-022594-fx044gcd	1291	27	the	the	DT
cord-022594-fx044gcd	1291	28	remyelinating	remyelinating	JJ
cord-022594-fx044gcd	1291	29	potential	potential	NN
cord-022594-fx044gcd	1291	30	of	of	IN
cord-022594-fx044gcd	1291	31	intravenous	intravenous	JJ
cord-022594-fx044gcd	1291	32	immunoglobulins	immunoglobulin	NNS
cord-022594-fx044gcd	1291	33	in	in	IN
cord-022594-fx044gcd	1291	34	multiple	multiple	JJ
cord-022594-fx044gcd	1291	35	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1292	1	A	a	DT
cord-022594-fx044gcd	1292	2	double	double	JJ
cord-022594-fx044gcd	1292	3	-	-	HYPH
cord-022594-fx044gcd	1292	4	blind	blind	JJ
cord-022594-fx044gcd	1292	5	,	,	,
cord-022594-fx044gcd	1292	6	randomized	randomized	JJ
cord-022594-fx044gcd	1292	7	trial	trial	NN
cord-022594-fx044gcd	1292	8	of	of	IN
cord-022594-fx044gcd	1292	9	IV	IV	NNP
cord-022594-fx044gcd	1292	10	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	1292	11	treatment	treatment	NN
cord-022594-fx044gcd	1292	12	in	in	IN
cord-022594-fx044gcd	1292	13	acute	acute	JJ
cord-022594-fx044gcd	1292	14	optic	optic	JJ
cord-022594-fx044gcd	1292	15	neuritis	neuritis	NN
cord-022594-fx044gcd	1293	1	A	a	DT
cord-022594-fx044gcd	1293	2	controlled	control	VBN
cord-022594-fx044gcd	1293	3	trial	trial	NN
cord-022594-fx044gcd	1293	4	of	of	IN
cord-022594-fx044gcd	1293	5	natalizumab	natalizumab	NNS
cord-022594-fx044gcd	1293	6	for	for	IN
cord-022594-fx044gcd	1293	7	relapsing	relapse	VBG
cord-022594-fx044gcd	1293	8	multiple	multiple	JJ
cord-022594-fx044gcd	1293	9	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1293	10	Progressive	progressive	JJ
cord-022594-fx044gcd	1293	11	multifocal	multifocal	JJ
cord-022594-fx044gcd	1293	12	leukoencephalopathy	leukoencephalopathy	NNP
cord-022594-fx044gcd	1293	13	complicating	complicate	VBG
cord-022594-fx044gcd	1293	14	treatment	treatment	NN
cord-022594-fx044gcd	1293	15	with	with	IN
cord-022594-fx044gcd	1293	16	natalizumab	natalizumab	NNS
cord-022594-fx044gcd	1293	17	and	and	CC
cord-022594-fx044gcd	1293	18	interferon	interferon	NNP
cord-022594-fx044gcd	1293	19	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1293	20	for	for	IN
cord-022594-fx044gcd	1293	21	multiple	multiple	JJ
cord-022594-fx044gcd	1293	22	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1293	23	T(1	T(1	NNP
cord-022594-fx044gcd	1293	24	)	)	-RRB-
cord-022594-fx044gcd	1294	1	hypointense	hypointense	NN
cord-022594-fx044gcd	1294	2	lesions	lesion	NNS
cord-022594-fx044gcd	1294	3	in	in	IN
cord-022594-fx044gcd	1294	4	secondary	secondary	JJ
cord-022594-fx044gcd	1294	5	progressive	progressive	JJ
cord-022594-fx044gcd	1294	6	multiple	multiple	JJ
cord-022594-fx044gcd	1294	7	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1294	8	:	:	:
cord-022594-fx044gcd	1294	9	Effect	effect	NN
cord-022594-fx044gcd	1294	10	of	of	IN
cord-022594-fx044gcd	1294	11	interferon	interferon	NN
cord-022594-fx044gcd	1294	12	beta-1b	beta-1b	CD
cord-022594-fx044gcd	1294	13	treatment	treatment	NN
cord-022594-fx044gcd	1294	14	Placebo	Placebo	NNP
cord-022594-fx044gcd	1294	15	-	-	HYPH
cord-022594-fx044gcd	1294	16	controlled	control	VBN
cord-022594-fx044gcd	1294	17	multicentre	multicentre	NNP
cord-022594-fx044gcd	1294	18	randomised	randomised	JJ
cord-022594-fx044gcd	1294	19	trial	trial	NN
cord-022594-fx044gcd	1294	20	of	of	IN
cord-022594-fx044gcd	1294	21	interferon	interferon	NN
cord-022594-fx044gcd	1294	22	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1294	23	in	in	IN
cord-022594-fx044gcd	1294	24	treatment	treatment	NN
cord-022594-fx044gcd	1294	25	of	of	IN
cord-022594-fx044gcd	1294	26	secondary	secondary	JJ
cord-022594-fx044gcd	1294	27	progressive	progressive	JJ
cord-022594-fx044gcd	1294	28	multiple	multiple	JJ
cord-022594-fx044gcd	1294	29	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1294	30	.	.	.
cord-022594-fx044gcd	1295	1	European	European	NNP
cord-022594-fx044gcd	1295	2	Study	Study	NNP
cord-022594-fx044gcd	1295	3	Group	Group	NNP
cord-022594-fx044gcd	1295	4	on	on	IN
cord-022594-fx044gcd	1295	5	interferon	interferon	NN
cord-022594-fx044gcd	1295	6	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1295	7	in	in	IN
cord-022594-fx044gcd	1295	8	secondary	secondary	JJ
cord-022594-fx044gcd	1295	9	progressive	progressive	JJ
cord-022594-fx044gcd	1295	10	MS	MS	NNP
cord-022594-fx044gcd	1295	11	Effect	Effect	NNP
cord-022594-fx044gcd	1295	12	of	of	IN
cord-022594-fx044gcd	1295	13	interferon	interferon	NN
cord-022594-fx044gcd	1295	14	-	-	:
cord-022594-fx044gcd	1295	15	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1295	16	on	on	IN
cord-022594-fx044gcd	1295	17	magnetic	magnetic	JJ
cord-022594-fx044gcd	1295	18	resonance	resonance	NN
cord-022594-fx044gcd	1295	19	imaging	imaging	NN
cord-022594-fx044gcd	1295	20	outcomes	outcome	NNS
cord-022594-fx044gcd	1295	21	in	in	IN
cord-022594-fx044gcd	1295	22	secondary	secondary	JJ
cord-022594-fx044gcd	1295	23	progressive	progressive	JJ
cord-022594-fx044gcd	1295	24	multiple	multiple	JJ
cord-022594-fx044gcd	1295	25	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1295	26	:	:	:
cord-022594-fx044gcd	1296	1	Results	result	NNS
cord-022594-fx044gcd	1296	2	of	of	IN
cord-022594-fx044gcd	1296	3	a	a	DT
cord-022594-fx044gcd	1296	4	European	european	JJ
cord-022594-fx044gcd	1296	5	multicenter	multicenter	NN
cord-022594-fx044gcd	1296	6	,	,	,
cord-022594-fx044gcd	1296	7	randomized	randomized	JJ
cord-022594-fx044gcd	1296	8	,	,	,
cord-022594-fx044gcd	1296	9	double	double	JJ
cord-022594-fx044gcd	1296	10	-	-	HYPH
cord-022594-fx044gcd	1296	11	blind	blind	JJ
cord-022594-fx044gcd	1296	12	,	,	,
cord-022594-fx044gcd	1296	13	placebo	placebo	NN
cord-022594-fx044gcd	1296	14	-	-	HYPH
cord-022594-fx044gcd	1296	15	controlled	control	VBN
cord-022594-fx044gcd	1296	16	trial	trial	NN
cord-022594-fx044gcd	1296	17	.	.	.
cord-022594-fx044gcd	1297	1	European	European	NNP
cord-022594-fx044gcd	1297	2	Study	Study	NNP
cord-022594-fx044gcd	1297	3	Group	Group	NNP
cord-022594-fx044gcd	1297	4	on	on	IN
cord-022594-fx044gcd	1297	5	Interferon	Interferon	NNP
cord-022594-fx044gcd	1297	6	-	-	HYPH
cord-022594-fx044gcd	1297	7	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1297	8	in	in	IN
cord-022594-fx044gcd	1297	9	secondary	secondary	JJ
cord-022594-fx044gcd	1297	10	progressive	progressive	JJ
cord-022594-fx044gcd	1297	11	multiple	multiple	JJ
cord-022594-fx044gcd	1297	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1297	13	Final	final	JJ
cord-022594-fx044gcd	1297	14	analysis	analysis	NN
cord-022594-fx044gcd	1297	15	of	of	IN
cord-022594-fx044gcd	1297	16	the	the	DT
cord-022594-fx044gcd	1297	17	European	european	JJ
cord-022594-fx044gcd	1297	18	multicenter	multicenter	JJ
cord-022594-fx044gcd	1297	19	trial	trial	NN
cord-022594-fx044gcd	1297	20	on	on	IN
cord-022594-fx044gcd	1297	21	IFNbeta-1b	IFNbeta-1b	NNP
cord-022594-fx044gcd	1297	22	in	in	IN
cord-022594-fx044gcd	1297	23	secondary	secondary	JJ
cord-022594-fx044gcd	1297	24	-	-	HYPH
cord-022594-fx044gcd	1297	25	progressive	progressive	JJ
cord-022594-fx044gcd	1297	26	MS	MS	NNP
cord-022594-fx044gcd	1298	1	The	the	DT
cord-022594-fx044gcd	1298	2	effect	effect	NN
cord-022594-fx044gcd	1298	3	of	of	IN
cord-022594-fx044gcd	1298	4	interferon	interferon	NN
cord-022594-fx044gcd	1298	5	beta-1b	beta-1b	CD
cord-022594-fx044gcd	1298	6	treatment	treatment	NN
cord-022594-fx044gcd	1298	7	on	on	IN
cord-022594-fx044gcd	1298	8	MRI	MRI	NNP
cord-022594-fx044gcd	1298	9	measures	measure	NNS
cord-022594-fx044gcd	1298	10	of	of	IN
cord-022594-fx044gcd	1298	11	cerebral	cerebral	JJ
cord-022594-fx044gcd	1298	12	atrophy	atrophy	NN
cord-022594-fx044gcd	1298	13	in	in	IN
cord-022594-fx044gcd	1298	14	secondary	secondary	JJ
cord-022594-fx044gcd	1298	15	progressive	progressive	JJ
cord-022594-fx044gcd	1298	16	multiple	multiple	JJ
cord-022594-fx044gcd	1298	17	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1298	18	.	.	.
cord-022594-fx044gcd	1299	1	European	European	NNP
cord-022594-fx044gcd	1299	2	Study	Study	NNP
cord-022594-fx044gcd	1299	3	Group	Group	NNP
cord-022594-fx044gcd	1299	4	on	on	IN
cord-022594-fx044gcd	1299	5	Interferon	Interferon	NNP
cord-022594-fx044gcd	1299	6	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1299	7	in	in	IN
cord-022594-fx044gcd	1299	8	secondary	secondary	JJ
cord-022594-fx044gcd	1299	9	progressive	progressive	JJ
cord-022594-fx044gcd	1299	10	multiple	multiple	JJ
cord-022594-fx044gcd	1299	11	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1299	12	Randomized	Randomized	NNP
cord-022594-fx044gcd	1299	13	controlled	control	VBN
cord-022594-fx044gcd	1299	14	trial	trial	NN
cord-022594-fx044gcd	1299	15	of	of	IN
cord-022594-fx044gcd	1299	16	interferonbeta-1a	interferonbeta-1a	NNP
cord-022594-fx044gcd	1299	17	in	in	IN
cord-022594-fx044gcd	1299	18	secondary	secondary	JJ
cord-022594-fx044gcd	1299	19	progressive	progressive	JJ
cord-022594-fx044gcd	1299	20	MS	MS	NNP
cord-022594-fx044gcd	1299	21	:	:	:
cord-022594-fx044gcd	1300	1	MRI	MRI	NNP
cord-022594-fx044gcd	1300	2	results	result	NNS
cord-022594-fx044gcd	1301	1	Interferon	interferon	NN
cord-022594-fx044gcd	1301	2	beta-1b	beta-1b	NNP
cord-022594-fx044gcd	1301	3	in	in	IN
cord-022594-fx044gcd	1301	4	secondary	secondary	JJ
cord-022594-fx044gcd	1301	5	progressive	progressive	JJ
cord-022594-fx044gcd	1301	6	MS	MS	NNP
cord-022594-fx044gcd	1301	7	:	:	:
cord-022594-fx044gcd	1301	8	A	a	DT
cord-022594-fx044gcd	1301	9	combined	combine	VBN
cord-022594-fx044gcd	1301	10	analysis	analysis	NN
cord-022594-fx044gcd	1301	11	of	of	IN
cord-022594-fx044gcd	1301	12	the	the	DT
cord-022594-fx044gcd	1301	13	two	two	CD
cord-022594-fx044gcd	1301	14	trials	trial	NNS
cord-022594-fx044gcd	1302	1	European	european	JJ
cord-022594-fx044gcd	1302	2	study	study	NN
cord-022594-fx044gcd	1302	3	on	on	IN
cord-022594-fx044gcd	1302	4	intravenous	intravenous	JJ
cord-022594-fx044gcd	1302	5	immunoglobulin	immunoglobulin	NN
cord-022594-fx044gcd	1302	6	in	in	IN
cord-022594-fx044gcd	1302	7	multiple	multiple	JJ
cord-022594-fx044gcd	1302	8	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1302	9	:	:	:
cord-022594-fx044gcd	1302	10	Results	result	NNS
cord-022594-fx044gcd	1302	11	of	of	IN
cord-022594-fx044gcd	1302	12	magnetization	magnetization	NN
cord-022594-fx044gcd	1302	13	transfer	transfer	NN
cord-022594-fx044gcd	1302	14	magnetic	magnetic	JJ
cord-022594-fx044gcd	1302	15	resonance	resonance	NN
cord-022594-fx044gcd	1302	16	imaging	imaging	NN
cord-022594-fx044gcd	1302	17	analysis	analysis	NN
cord-022594-fx044gcd	1302	18	Relapses	relapse	NNS
cord-022594-fx044gcd	1302	19	and	and	CC
cord-022594-fx044gcd	1302	20	progression	progression	NN
cord-022594-fx044gcd	1302	21	of	of	IN
cord-022594-fx044gcd	1302	22	disability	disability	NN
cord-022594-fx044gcd	1302	23	in	in	IN
cord-022594-fx044gcd	1302	24	multiple	multiple	JJ
cord-022594-fx044gcd	1302	25	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1303	1	Mitoxantrone	Mitoxantrone	NNP
cord-022594-fx044gcd	1303	2	in	in	IN
cord-022594-fx044gcd	1303	3	progressive	progressive	JJ
cord-022594-fx044gcd	1303	4	MS	MS	NNP
cord-022594-fx044gcd	1303	5	:	:	:
cord-022594-fx044gcd	1304	1	A	a	DT
cord-022594-fx044gcd	1304	2	placebo	placebo	NN
cord-022594-fx044gcd	1304	3	controlled	control	VBN
cord-022594-fx044gcd	1304	4	,	,	,
cord-022594-fx044gcd	1304	5	randomized	randomized	JJ
cord-022594-fx044gcd	1304	6	,	,	,
cord-022594-fx044gcd	1304	7	observer	observer	NN
cord-022594-fx044gcd	1304	8	blinded	blinded	JJ
cord-022594-fx044gcd	1304	9	phase	phase	NN
cord-022594-fx044gcd	1304	10	III	iii	CD
cord-022594-fx044gcd	1304	11	multi	multi	JJ
cord-022594-fx044gcd	1304	12	-	-	JJ
cord-022594-fx044gcd	1304	13	center	center	JJ
cord-022594-fx044gcd	1304	14	study	study	NN
cord-022594-fx044gcd	1304	15	:	:	:
cord-022594-fx044gcd	1304	16	Clinical	clinical	JJ
cord-022594-fx044gcd	1304	17	results	result	NNS
cord-022594-fx044gcd	1304	18	Therapeutic	therapeutic	JJ
cord-022594-fx044gcd	1304	19	effect	effect	NN
cord-022594-fx044gcd	1304	20	of	of	IN
cord-022594-fx044gcd	1304	21	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	1304	22	combined	combine	VBN
cord-022594-fx044gcd	1304	23	with	with	IN
cord-022594-fx044gcd	1304	24	methylprednisolone	methylprednisolone	NN
cord-022594-fx044gcd	1304	25	in	in	IN
cord-022594-fx044gcd	1304	26	multiple	multiple	JJ
cord-022594-fx044gcd	1304	27	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1304	28	:	:	:
cord-022594-fx044gcd	1305	1	A	a	DT
cord-022594-fx044gcd	1305	2	randomised	randomised	JJ
cord-022594-fx044gcd	1305	3	multicentre	multicentre	NNP
cord-022594-fx044gcd	1305	4	study	study	NN
cord-022594-fx044gcd	1305	5	of	of	IN
cord-022594-fx044gcd	1305	6	active	active	JJ
cord-022594-fx044gcd	1305	7	disease	disease	NN
cord-022594-fx044gcd	1305	8	using	use	VBG
cord-022594-fx044gcd	1305	9	MRI	MRI	NNP
cord-022594-fx044gcd	1305	10	and	and	CC
cord-022594-fx044gcd	1305	11	clinical	clinical	JJ
cord-022594-fx044gcd	1305	12	criteria	criterion	NNS
cord-022594-fx044gcd	1306	1	A	a	DT
cord-022594-fx044gcd	1306	2	study	study	NN
cord-022594-fx044gcd	1306	3	of	of	IN
cord-022594-fx044gcd	1306	4	therapy	therapy	NN
cord-022594-fx044gcd	1306	5	-	-	HYPH
cord-022594-fx044gcd	1306	6	related	relate	VBN
cord-022594-fx044gcd	1306	7	acute	acute	JJ
cord-022594-fx044gcd	1306	8	leukaemia	leukaemia	NN
cord-022594-fx044gcd	1306	9	after	after	IN
cord-022594-fx044gcd	1306	10	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	1306	11	therapy	therapy	NN
cord-022594-fx044gcd	1306	12	for	for	IN
cord-022594-fx044gcd	1306	13	multiple	multiple	JJ
cord-022594-fx044gcd	1306	14	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1307	1	Mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	1307	2	in	in	IN
cord-022594-fx044gcd	1307	3	progressive	progressive	JJ
cord-022594-fx044gcd	1307	4	multiple	multiple	JJ
cord-022594-fx044gcd	1307	5	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1307	6	:	:	:
cord-022594-fx044gcd	1307	7	A	a	DT
cord-022594-fx044gcd	1307	8	placebo	placebo	NN
cord-022594-fx044gcd	1307	9	-	-	HYPH
cord-022594-fx044gcd	1307	10	controlled	control	VBN
cord-022594-fx044gcd	1307	11	,	,	,
cord-022594-fx044gcd	1307	12	double	double	JJ
cord-022594-fx044gcd	1307	13	-	-	HYPH
cord-022594-fx044gcd	1307	14	blind	blind	JJ
cord-022594-fx044gcd	1307	15	,	,	,
cord-022594-fx044gcd	1307	16	randomised	randomised	JJ
cord-022594-fx044gcd	1307	17	,	,	,
cord-022594-fx044gcd	1307	18	multicentre	multicentre	NNP
cord-022594-fx044gcd	1307	19	trial	trial	NN
cord-022594-fx044gcd	1307	20	Effect	Effect	NNP
cord-022594-fx044gcd	1307	21	of	of	IN
cord-022594-fx044gcd	1307	22	mitoxantrone	mitoxantrone	NN
cord-022594-fx044gcd	1307	23	on	on	IN
cord-022594-fx044gcd	1307	24	MRI	MRI	NNP
cord-022594-fx044gcd	1307	25	in	in	IN
cord-022594-fx044gcd	1307	26	progressive	progressive	JJ
cord-022594-fx044gcd	1307	27	MS	MS	NNP
cord-022594-fx044gcd	1307	28	:	:	:
cord-022594-fx044gcd	1307	29	Results	result	NNS
cord-022594-fx044gcd	1307	30	of	of	IN
cord-022594-fx044gcd	1307	31	the	the	DT
cord-022594-fx044gcd	1307	32	MIMS	MIMS	NNP
cord-022594-fx044gcd	1307	33	trial	trial	NN
cord-022594-fx044gcd	1308	1	Interferon	Interferon	NNP
cord-022594-fx044gcd	1308	2	beta-1a	beta-1a	NNP
cord-022594-fx044gcd	1308	3	in	in	IN
cord-022594-fx044gcd	1308	4	primary	primary	JJ
cord-022594-fx044gcd	1308	5	progressive	progressive	JJ
cord-022594-fx044gcd	1308	6	multiple	multiple	JJ
cord-022594-fx044gcd	1308	7	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1308	8	Overview	Overview	NNP
cord-022594-fx044gcd	1308	9	of	of	IN
cord-022594-fx044gcd	1308	10	azathioprine	azathioprine	JJ
cord-022594-fx044gcd	1308	11	treatment	treatment	NN
cord-022594-fx044gcd	1308	12	in	in	IN
cord-022594-fx044gcd	1308	13	multiple	multiple	JJ
cord-022594-fx044gcd	1308	14	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1308	15	Lowdose	Lowdose	NNP
cord-022594-fx044gcd	1308	16	(	(	-LRB-
cord-022594-fx044gcd	1308	17	7.5	7.5	CD
cord-022594-fx044gcd	1308	18	mg	mg	NN
cord-022594-fx044gcd	1308	19	)	)	-RRB-
cord-022594-fx044gcd	1309	1	oral	oral	NNP
cord-022594-fx044gcd	1309	2	methotrexate	methotrexate	NNP
cord-022594-fx044gcd	1309	3	reduces	reduce	VBZ
cord-022594-fx044gcd	1309	4	the	the	DT
cord-022594-fx044gcd	1309	5	rate	rate	NN
cord-022594-fx044gcd	1309	6	of	of	IN
cord-022594-fx044gcd	1309	7	progression	progression	NN
cord-022594-fx044gcd	1309	8	in	in	IN
cord-022594-fx044gcd	1309	9	chronic	chronic	JJ
cord-022594-fx044gcd	1309	10	progressive	progressive	JJ
cord-022594-fx044gcd	1309	11	multiple	multiple	JJ
cord-022594-fx044gcd	1309	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1309	13	Cladribine	Cladribine	NNP
cord-022594-fx044gcd	1309	14	in	in	IN
cord-022594-fx044gcd	1309	15	treatment	treatment	NN
cord-022594-fx044gcd	1309	16	of	of	IN
cord-022594-fx044gcd	1309	17	chronic	chronic	JJ
cord-022594-fx044gcd	1309	18	progressive	progressive	JJ
cord-022594-fx044gcd	1309	19	multiple	multiple	JJ
cord-022594-fx044gcd	1309	20	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1309	21	Cladribine	Cladribine	NNP
cord-022594-fx044gcd	1309	22	and	and	CC
cord-022594-fx044gcd	1309	23	progressive	progressive	JJ
cord-022594-fx044gcd	1309	24	MS	MS	NNP
cord-022594-fx044gcd	1309	25	:	:	:
cord-022594-fx044gcd	1309	26	clinical	clinical	JJ
cord-022594-fx044gcd	1309	27	and	and	CC
cord-022594-fx044gcd	1309	28	MRI	MRI	NNP
cord-022594-fx044gcd	1309	29	outcomes	outcome	NNS
cord-022594-fx044gcd	1309	30	of	of	IN
cord-022594-fx044gcd	1309	31	a	a	DT
cord-022594-fx044gcd	1309	32	multicenter	multicenter	NN
cord-022594-fx044gcd	1309	33	controlled	control	VBN
cord-022594-fx044gcd	1309	34	trial	trial	NN
cord-022594-fx044gcd	1309	35	.	.	.
cord-022594-fx044gcd	1310	1	Cladribine	Cladribine	NNP
cord-022594-fx044gcd	1310	2	MRI	MRI	NNP
cord-022594-fx044gcd	1310	3	Study	Study	NNP
cord-022594-fx044gcd	1310	4	Group	Group	NNP
cord-022594-fx044gcd	1310	5	Autologous	autologous	JJ
cord-022594-fx044gcd	1310	6	stem	stem	NN
cord-022594-fx044gcd	1310	7	cell	cell	NN
cord-022594-fx044gcd	1310	8	transplantation	transplantation	NN
cord-022594-fx044gcd	1310	9	in	in	IN
cord-022594-fx044gcd	1310	10	progressive	progressive	JJ
cord-022594-fx044gcd	1310	11	multiple	multiple	JJ
cord-022594-fx044gcd	1310	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1310	13	-	-	:
cord-022594-fx044gcd	1310	14	An	an	DT
cord-022594-fx044gcd	1310	15	interim	interim	JJ
cord-022594-fx044gcd	1310	16	analysis	analysis	NN
cord-022594-fx044gcd	1310	17	of	of	IN
cord-022594-fx044gcd	1310	18	efficacy	efficacy	NN
cord-022594-fx044gcd	1310	19	Controlled	control	VBN
cord-022594-fx044gcd	1310	20	randomised	randomised	JJ
cord-022594-fx044gcd	1310	21	crossover	crossover	NN
cord-022594-fx044gcd	1310	22	trial	trial	NN
cord-022594-fx044gcd	1310	23	of	of	IN
cord-022594-fx044gcd	1310	24	the	the	DT
cord-022594-fx044gcd	1310	25	effects	effect	NNS
cord-022594-fx044gcd	1310	26	of	of	IN
cord-022594-fx044gcd	1310	27	physiotherapy	physiotherapy	NN
cord-022594-fx044gcd	1310	28	on	on	IN
cord-022594-fx044gcd	1310	29	mobility	mobility	NN
cord-022594-fx044gcd	1310	30	in	in	IN
cord-022594-fx044gcd	1310	31	chronic	chronic	JJ
cord-022594-fx044gcd	1310	32	multiple	multiple	JJ
cord-022594-fx044gcd	1310	33	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1311	1	A	a	DT
cord-022594-fx044gcd	1311	2	randomized	randomized	JJ
cord-022594-fx044gcd	1311	3	controlled	control	VBN
cord-022594-fx044gcd	1311	4	crossover	crossover	NN
cord-022594-fx044gcd	1311	5	trial	trial	NN
cord-022594-fx044gcd	1311	6	of	of	IN
cord-022594-fx044gcd	1311	7	aspirin	aspirin	NN
cord-022594-fx044gcd	1311	8	for	for	IN
cord-022594-fx044gcd	1311	9	fatigue	fatigue	NN
cord-022594-fx044gcd	1311	10	in	in	IN
cord-022594-fx044gcd	1311	11	multiple	multiple	JJ
cord-022594-fx044gcd	1311	12	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1311	13	Donepezil	Donepezil	NNP
cord-022594-fx044gcd	1311	14	improved	improve	VBD
cord-022594-fx044gcd	1311	15	memory	memory	NN
cord-022594-fx044gcd	1311	16	in	in	IN
cord-022594-fx044gcd	1311	17	multiple	multiple	JJ
cord-022594-fx044gcd	1311	18	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1311	19	in	in	IN
cord-022594-fx044gcd	1311	20	a	a	DT
cord-022594-fx044gcd	1311	21	randomized	randomized	JJ
cord-022594-fx044gcd	1311	22	clinical	clinical	JJ
cord-022594-fx044gcd	1311	23	trial	trial	NN
cord-022594-fx044gcd	1311	24	Stereotactic	Stereotactic	NNP
cord-022594-fx044gcd	1311	25	lesional	lesional	JJ
cord-022594-fx044gcd	1311	26	surgery	surgery	NN
cord-022594-fx044gcd	1311	27	for	for	IN
cord-022594-fx044gcd	1311	28	the	the	DT
cord-022594-fx044gcd	1311	29	treatment	treatment	NN
cord-022594-fx044gcd	1311	30	of	of	IN
cord-022594-fx044gcd	1311	31	tremor	tremor	NN
cord-022594-fx044gcd	1311	32	in	in	IN
cord-022594-fx044gcd	1311	33	multiple	multiple	JJ
cord-022594-fx044gcd	1311	34	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1311	35	:	:	:
cord-022594-fx044gcd	1312	1	A	a	DT
cord-022594-fx044gcd	1312	2	prospective	prospective	JJ
cord-022594-fx044gcd	1312	3	case	case	NN
cord-022594-fx044gcd	1312	4	-	-	HYPH
cord-022594-fx044gcd	1312	5	controlled	control	VBN
cord-022594-fx044gcd	1312	6	study	study	NN
cord-022594-fx044gcd	1312	7	A	a	DT
cord-022594-fx044gcd	1312	8	study	study	NN
cord-022594-fx044gcd	1312	9	of	of	IN
cord-022594-fx044gcd	1312	10	tremor	tremor	NN
cord-022594-fx044gcd	1312	11	in	in	IN
cord-022594-fx044gcd	1312	12	multiple	multiple	JJ
cord-022594-fx044gcd	1312	13	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1312	14	Ventilatory	ventilatory	JJ
cord-022594-fx044gcd	1312	15	dysfunction	dysfunction	NN
cord-022594-fx044gcd	1312	16	in	in	IN
cord-022594-fx044gcd	1312	17	multiple	multiple	JJ
cord-022594-fx044gcd	1312	18	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1313	1	The	the	DT
cord-022594-fx044gcd	1313	2	reproductive	reproductive	JJ
cord-022594-fx044gcd	1313	3	effects	effect	NNS
cord-022594-fx044gcd	1313	4	of	of	IN
cord-022594-fx044gcd	1313	5	beta	beta	NN
cord-022594-fx044gcd	1313	6	interferon	interferon	NN
cord-022594-fx044gcd	1313	7	therapy	therapy	NN
cord-022594-fx044gcd	1313	8	in	in	IN
cord-022594-fx044gcd	1313	9	pregnancy	pregnancy	NN
cord-022594-fx044gcd	1313	10	:	:	:
cord-022594-fx044gcd	1314	1	A	a	DT
cord-022594-fx044gcd	1314	2	longitudinal	longitudinal	JJ
cord-022594-fx044gcd	1314	3	cohort	cohort	NN
cord-022594-fx044gcd	1315	1	The	the	DT
cord-022594-fx044gcd	1315	2	natural	natural	JJ
cord-022594-fx044gcd	1315	3	history	history	NN
cord-022594-fx044gcd	1315	4	of	of	IN
cord-022594-fx044gcd	1315	5	multiple	multiple	JJ
cord-022594-fx044gcd	1315	6	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1315	7	:	:	:
cord-022594-fx044gcd	1316	1	A	a	DT
cord-022594-fx044gcd	1316	2	geographically	geographically	RB
cord-022594-fx044gcd	1316	3	based	base	VBN
cord-022594-fx044gcd	1316	4	study	study	NN
cord-022594-fx044gcd	1316	5	.	.	.
cord-022594-fx044gcd	1317	1	I.	I.	NNP
cord-022594-fx044gcd	1317	2	Clinical	clinical	JJ
cord-022594-fx044gcd	1317	3	course	course	NN
cord-022594-fx044gcd	1317	4	and	and	CC
cord-022594-fx044gcd	1317	5	disability	disability	NN
cord-022594-fx044gcd	1317	6	Change	change	NN
cord-022594-fx044gcd	1317	7	in	in	IN
cord-022594-fx044gcd	1317	8	MS	MS	NNP
cord-022594-fx044gcd	1317	9	-	-	HYPH
cord-022594-fx044gcd	1317	10	related	relate	VBN
cord-022594-fx044gcd	1317	11	disability	disability	NN
cord-022594-fx044gcd	1317	12	in	in	IN
cord-022594-fx044gcd	1317	13	a	a	DT
cord-022594-fx044gcd	1317	14	population	population	NN
cord-022594-fx044gcd	1317	15	-	-	HYPH
cord-022594-fx044gcd	1317	16	based	base	VBN
cord-022594-fx044gcd	1317	17	cohort	cohort	NN
cord-022594-fx044gcd	1317	18	:	:	:
cord-022594-fx044gcd	1317	19	A	a	DT
cord-022594-fx044gcd	1317	20	10-year	10-year	CD
cord-022594-fx044gcd	1317	21	follow	follow	NN
cord-022594-fx044gcd	1317	22	-	-	HYPH
cord-022594-fx044gcd	1317	23	up	up	NN
cord-022594-fx044gcd	1317	24	study	study	NN
cord-022594-fx044gcd	1317	25	The	the	DT
cord-022594-fx044gcd	1317	26	clinical	clinical	JJ
cord-022594-fx044gcd	1317	27	course	course	NN
cord-022594-fx044gcd	1317	28	of	of	IN
cord-022594-fx044gcd	1317	29	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	1317	30	optica	optica	NNP
cord-022594-fx044gcd	1317	31	(	(	-LRB-
cord-022594-fx044gcd	1317	32	Devic	Devic	NNP
cord-022594-fx044gcd	1317	33	's	's	POS
cord-022594-fx044gcd	1317	34	syndrome	syndrome	NN
cord-022594-fx044gcd	1317	35	)	)	-RRB-
cord-022594-fx044gcd	1318	1	Devic	Devic	NNP
cord-022594-fx044gcd	1318	2	's	's	POS
cord-022594-fx044gcd	1318	3	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	1318	4	optica	optica	NNP
cord-022594-fx044gcd	1318	5	:	:	:
cord-022594-fx044gcd	1319	1	A	a	DT
cord-022594-fx044gcd	1319	2	clinicopathological	clinicopathological	JJ
cord-022594-fx044gcd	1319	3	study	study	NN
cord-022594-fx044gcd	1319	4	of	of	IN
cord-022594-fx044gcd	1319	5	8	8	CD
cord-022594-fx044gcd	1319	6	patients	patient	NNS
cord-022594-fx044gcd	1319	7	A	a	DT
cord-022594-fx044gcd	1319	8	serum	serum	NN
cord-022594-fx044gcd	1319	9	autoantibody	autoantibody	NN
cord-022594-fx044gcd	1319	10	marker	marker	NN
cord-022594-fx044gcd	1319	11	of	of	IN
cord-022594-fx044gcd	1319	12	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	1319	13	optica	optica	NNP
cord-022594-fx044gcd	1319	14	:	:	:
cord-022594-fx044gcd	1320	1	Distinction	distinction	NN
cord-022594-fx044gcd	1320	2	from	from	IN
cord-022594-fx044gcd	1320	3	multiple	multiple	JJ
cord-022594-fx044gcd	1320	4	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1321	1	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	1321	2	optica	optica	NN
cord-022594-fx044gcd	1321	3	:	:	:
cord-022594-fx044gcd	1322	1	Clinical	clinical	JJ
cord-022594-fx044gcd	1322	2	predictors	predictor	NNS
cord-022594-fx044gcd	1322	3	of	of	IN
cord-022594-fx044gcd	1322	4	a	a	DT
cord-022594-fx044gcd	1322	5	relapsing	relapse	VBG
cord-022594-fx044gcd	1322	6	course	course	NN
cord-022594-fx044gcd	1322	7	and	and	CC
cord-022594-fx044gcd	1322	8	survival	survival	NN
cord-022594-fx044gcd	1322	9	MRI	MRI	NNP
cord-022594-fx044gcd	1322	10	and	and	CC
cord-022594-fx044gcd	1322	11	magnetization	magnetization	NN
cord-022594-fx044gcd	1322	12	transfer	transfer	NN
cord-022594-fx044gcd	1322	13	imaging	imaging	NN
cord-022594-fx044gcd	1322	14	changes	change	NNS
cord-022594-fx044gcd	1322	15	in	in	IN
cord-022594-fx044gcd	1322	16	the	the	DT
cord-022594-fx044gcd	1322	17	brain	brain	NN
cord-022594-fx044gcd	1322	18	and	and	CC
cord-022594-fx044gcd	1322	19	cervical	cervical	JJ
cord-022594-fx044gcd	1322	20	cord	cord	NN
cord-022594-fx044gcd	1322	21	of	of	IN
cord-022594-fx044gcd	1322	22	patients	patient	NNS
cord-022594-fx044gcd	1322	23	with	with	IN
cord-022594-fx044gcd	1322	24	Devic	Devic	NNP
cord-022594-fx044gcd	1322	25	's	's	POS
cord-022594-fx044gcd	1322	26	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	1322	27	optica	optica	NNP
cord-022594-fx044gcd	1322	28	Clinical	Clinical	NNP
cord-022594-fx044gcd	1322	29	,	,	,
cord-022594-fx044gcd	1322	30	CSF	CSF	NNP
cord-022594-fx044gcd	1322	31	,	,	,
cord-022594-fx044gcd	1322	32	and	and	CC
cord-022594-fx044gcd	1322	33	MRI	MRI	NNP
cord-022594-fx044gcd	1322	34	findings	finding	NNS
cord-022594-fx044gcd	1322	35	in	in	IN
cord-022594-fx044gcd	1322	36	Devic	Devic	NNP
cord-022594-fx044gcd	1322	37	's	's	POS
cord-022594-fx044gcd	1322	38	neuromyelitis	neuromyelitis	NNP
cord-022594-fx044gcd	1322	39	optica	optica	NNP
cord-022594-fx044gcd	1323	1	Neuromyelitis	Neuromyelitis	NNP
cord-022594-fx044gcd	1323	2	optica	optica	NN
cord-022594-fx044gcd	1323	3	Acute	acute	NN
cord-022594-fx044gcd	1323	4	disseminated	disseminate	VBN
cord-022594-fx044gcd	1323	5	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	1323	6	:	:	:
cord-022594-fx044gcd	1323	7	A	a	DT
cord-022594-fx044gcd	1323	8	follow	follow	VB
cord-022594-fx044gcd	1323	9	-	-	HYPH
cord-022594-fx044gcd	1323	10	up	up	NN
cord-022594-fx044gcd	1323	11	study	study	NN
cord-022594-fx044gcd	1323	12	of	of	IN
cord-022594-fx044gcd	1323	13	40	40	CD
cord-022594-fx044gcd	1323	14	adult	adult	NN
cord-022594-fx044gcd	1323	15	patients	patient	NNS
cord-022594-fx044gcd	1323	16	ADEM	ADEM	NNP
cord-022594-fx044gcd	1323	17	:	:	:
cord-022594-fx044gcd	1323	18	Distinct	distinct	JJ
cord-022594-fx044gcd	1323	19	disease	disease	NN
cord-022594-fx044gcd	1323	20	or	or	CC
cord-022594-fx044gcd	1323	21	part	part	NN
cord-022594-fx044gcd	1323	22	of	of	IN
cord-022594-fx044gcd	1323	23	the	the	DT
cord-022594-fx044gcd	1323	24	MS	MS	NNP
cord-022594-fx044gcd	1323	25	spectrum	spectrum	NN
cord-022594-fx044gcd	1323	26	Clinical	Clinical	NNP
cord-022594-fx044gcd	1323	27	and	and	CC
cord-022594-fx044gcd	1323	28	neuroradiologic	neuroradiologic	JJ
cord-022594-fx044gcd	1323	29	features	feature	NNS
cord-022594-fx044gcd	1323	30	of	of	IN
cord-022594-fx044gcd	1323	31	acute	acute	JJ
cord-022594-fx044gcd	1323	32	disseminated	disseminate	VBN
cord-022594-fx044gcd	1323	33	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	1323	34	in	in	IN
cord-022594-fx044gcd	1323	35	children	child	NNS
cord-022594-fx044gcd	1323	36	Acute	Acute	NNP
cord-022594-fx044gcd	1323	37	disseminated	disseminate	VBN
cord-022594-fx044gcd	1323	38	encephalomyelitis	encephalomyelitis	NN
cord-022594-fx044gcd	1323	39	.	.	.
cord-022594-fx044gcd	1324	1	MRI	MRI	NNP
cord-022594-fx044gcd	1324	2	findings	finding	NNS
cord-022594-fx044gcd	1324	3	and	and	CC
cord-022594-fx044gcd	1324	4	the	the	DT
cord-022594-fx044gcd	1324	5	distinction	distinction	NN
cord-022594-fx044gcd	1324	6	from	from	IN
cord-022594-fx044gcd	1324	7	multiple	multiple	JJ
cord-022594-fx044gcd	1324	8	sclerosis	sclerosis	NN
cord-022594-fx044gcd	1324	9	Interactive	interactive	JJ
cord-022594-fx044gcd	1324	10	study	study	NN
cord-022594-fx044gcd	1324	11	questions	question	NNS
cord-022594-fx044gcd	1324	12	and	and	CC
cord-022594-fx044gcd	1324	13	referenced	reference	VBD
cord-022594-fx044gcd	1324	14	videos	video	NNS
cord-022594-fx044gcd	1324	15	for	for	IN
cord-022594-fx044gcd	1324	16	this	this	DT
cord-022594-fx044gcd	1324	17	chapter	chapter	NN
cord-022594-fx044gcd	1324	18	are	be	VBP
cord-022594-fx044gcd	1324	19	available	available	JJ
cord-022594-fx044gcd	1324	20	on	on	IN
cord-022594-fx044gcd	1324	21	the	the	DT
cord-022594-fx044gcd	1324	22	DVD	dvd	NN
cord-022594-fx044gcd	1324	23	-	-	HYPH
cord-022594-fx044gcd	1324	24	ROM	rom	NN