id	sid	tid	token	lemma	pos
cord-332109-ont0tqpn	1	1	key	key	NN
cord-332109-ont0tqpn	1	2	:	:	:
cord-332109-ont0tqpn	1	3	cord-332109-ont0tqpn	cord-332109-ont0tqpn	CD
cord-332109-ont0tqpn	1	4	authors	author	NNS
cord-332109-ont0tqpn	1	5	:	:	:
cord-332109-ont0tqpn	1	6	Wei	Wei	NNP
cord-332109-ont0tqpn	1	7	,	,	,
cord-332109-ont0tqpn	1	8	Yufeng	Yufeng	NNP
cord-332109-ont0tqpn	1	9	;	;	:
cord-332109-ont0tqpn	1	10	Shah	Shah	NNP
cord-332109-ont0tqpn	2	1	,	,	,
cord-332109-ont0tqpn	2	2	Rameen	Rameen	NNP
cord-332109-ont0tqpn	2	3	title	title	NN
cord-332109-ont0tqpn	2	4	:	:	:
cord-332109-ont0tqpn	3	1	Substance	substance	NN
cord-332109-ont0tqpn	3	2	Use	Use	NNP
cord-332109-ont0tqpn	3	3	Disorder	disorder	NN
cord-332109-ont0tqpn	3	4	in	in	IN
cord-332109-ont0tqpn	3	5	the	the	DT
cord-332109-ont0tqpn	3	6	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	3	7	Pandemic	Pandemic	NNP
cord-332109-ont0tqpn	3	8	:	:	:
cord-332109-ont0tqpn	4	1	A	a	DT
cord-332109-ont0tqpn	4	2	Systematic	Systematic	NNP
cord-332109-ont0tqpn	4	3	Review	Review	NNP
cord-332109-ont0tqpn	4	4	of	of	IN
cord-332109-ont0tqpn	4	5	Vulnerabilities	Vulnerabilities	NNPS
cord-332109-ont0tqpn	4	6	and	and	CC
cord-332109-ont0tqpn	4	7	Complications	Complications	NNPS
cord-332109-ont0tqpn	4	8	date	date	NN
cord-332109-ont0tqpn	4	9	:	:	:
cord-332109-ont0tqpn	4	10	2020	2020	CD
cord-332109-ont0tqpn	4	11	-	-	HYPH
cord-332109-ont0tqpn	4	12	07	07	CD
cord-332109-ont0tqpn	4	13	-	-	SYM
cord-332109-ont0tqpn	4	14	18	18	CD
cord-332109-ont0tqpn	4	15	journal	journal	NN
cord-332109-ont0tqpn	4	16	:	:	:
cord-332109-ont0tqpn	4	17	Pharmaceuticals	Pharmaceuticals	NNP
cord-332109-ont0tqpn	4	18	(	(	-LRB-
cord-332109-ont0tqpn	4	19	Basel	Basel	NNP
cord-332109-ont0tqpn	4	20	)	)	-RRB-
cord-332109-ont0tqpn	4	21	DOI	DOI	NNP
cord-332109-ont0tqpn	4	22	:	:	:
cord-332109-ont0tqpn	5	1	10.3390	10.3390	CD
cord-332109-ont0tqpn	5	2	/	/	SYM
cord-332109-ont0tqpn	5	3	ph13070155	ph13070155	NNP
cord-332109-ont0tqpn	5	4	sha	sha	NNP
cord-332109-ont0tqpn	5	5	:	:	:
cord-332109-ont0tqpn	6	1	68306c66e265e3245cc8db55e7a8e54269475197	68306c66e265e3245cc8db55e7a8e54269475197	CD
cord-332109-ont0tqpn	7	1	doc_id	doc_id	CD
cord-332109-ont0tqpn	7	2	:	:	:
cord-332109-ont0tqpn	7	3	332109	332109	CD
cord-332109-ont0tqpn	7	4	cord_uid	cord_uid	NNS
cord-332109-ont0tqpn	7	5	:	:	:
cord-332109-ont0tqpn	8	1	ont0tqpn	ont0tqpn	RB
cord-332109-ont0tqpn	8	2	As	as	IN
cord-332109-ont0tqpn	8	3	the	the	DT
cord-332109-ont0tqpn	8	4	world	world	NN
cord-332109-ont0tqpn	8	5	endures	endure	VBZ
cord-332109-ont0tqpn	8	6	the	the	DT
cord-332109-ont0tqpn	8	7	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	8	8	disease	disease	NN
cord-332109-ont0tqpn	8	9	2019	2019	CD
cord-332109-ont0tqpn	8	10	(	(	-LRB-
cord-332109-ont0tqpn	8	11	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	8	12	)	)	-RRB-
cord-332109-ont0tqpn	8	13	pandemic	pandemic	NN
cord-332109-ont0tqpn	8	14	,	,	,
cord-332109-ont0tqpn	8	15	the	the	DT
cord-332109-ont0tqpn	8	16	conditions	condition	NNS
cord-332109-ont0tqpn	8	17	of	of	IN
cord-332109-ont0tqpn	8	18	35	35	CD
cord-332109-ont0tqpn	8	19	million	million	CD
cord-332109-ont0tqpn	8	20	vulnerable	vulnerable	JJ
cord-332109-ont0tqpn	8	21	individuals	individual	NNS
cord-332109-ont0tqpn	8	22	struggling	struggle	VBG
cord-332109-ont0tqpn	8	23	with	with	IN
cord-332109-ont0tqpn	8	24	substance	substance	NN
cord-332109-ont0tqpn	8	25	use	use	NN
cord-332109-ont0tqpn	8	26	disorders	disorder	NNS
cord-332109-ont0tqpn	8	27	(	(	-LRB-
cord-332109-ont0tqpn	8	28	SUDs	sud	NNS
cord-332109-ont0tqpn	8	29	)	)	-RRB-
cord-332109-ont0tqpn	8	30	worldwide	worldwide	RB
cord-332109-ont0tqpn	8	31	have	have	VBP
cord-332109-ont0tqpn	8	32	not	not	RB
cord-332109-ont0tqpn	8	33	received	receive	VBN
cord-332109-ont0tqpn	8	34	sufficient	sufficient	JJ
cord-332109-ont0tqpn	8	35	attention	attention	NN
cord-332109-ont0tqpn	8	36	for	for	IN
cord-332109-ont0tqpn	8	37	their	-PRON-	PRP$
cord-332109-ont0tqpn	8	38	special	special	JJ
cord-332109-ont0tqpn	8	39	health	health	NN
cord-332109-ont0tqpn	8	40	and	and	CC
cord-332109-ont0tqpn	8	41	medical	medical	JJ
cord-332109-ont0tqpn	8	42	needs	need	NNS
cord-332109-ont0tqpn	8	43	.	.	.
cord-332109-ont0tqpn	9	1	Many	many	JJ
cord-332109-ont0tqpn	9	2	of	of	IN
cord-332109-ont0tqpn	9	3	these	these	DT
cord-332109-ont0tqpn	9	4	individuals	individual	NNS
cord-332109-ont0tqpn	9	5	are	be	VBP
cord-332109-ont0tqpn	9	6	complicated	complicate	VBN
cord-332109-ont0tqpn	9	7	by	by	IN
cord-332109-ont0tqpn	9	8	underlying	underlie	VBG
cord-332109-ont0tqpn	9	9	health	health	NN
cord-332109-ont0tqpn	9	10	conditions	condition	NNS
cord-332109-ont0tqpn	9	11	,	,	,
cord-332109-ont0tqpn	9	12	such	such	JJ
cord-332109-ont0tqpn	9	13	as	as	IN
cord-332109-ont0tqpn	9	14	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	9	15	and	and	CC
cord-332109-ont0tqpn	9	16	lung	lung	NN
cord-332109-ont0tqpn	9	17	diseases	disease	NNS
cord-332109-ont0tqpn	9	18	and	and	CC
cord-332109-ont0tqpn	9	19	undermined	undermine	VBD
cord-332109-ont0tqpn	9	20	immune	immune	JJ
cord-332109-ont0tqpn	9	21	systems	system	NNS
cord-332109-ont0tqpn	9	22	.	.	.
cord-332109-ont0tqpn	10	1	During	during	IN
cord-332109-ont0tqpn	10	2	the	the	DT
cord-332109-ont0tqpn	10	3	pandemic	pandemic	NN
cord-332109-ont0tqpn	10	4	,	,	,
cord-332109-ont0tqpn	10	5	access	access	NN
cord-332109-ont0tqpn	10	6	to	to	IN
cord-332109-ont0tqpn	10	7	the	the	DT
cord-332109-ont0tqpn	10	8	healthcare	healthcare	NN
cord-332109-ont0tqpn	10	9	systems	system	NNS
cord-332109-ont0tqpn	10	10	and	and	CC
cord-332109-ont0tqpn	10	11	support	support	NN
cord-332109-ont0tqpn	10	12	groups	group	NNS
cord-332109-ont0tqpn	10	13	is	be	VBZ
cord-332109-ont0tqpn	10	14	greatly	greatly	RB
cord-332109-ont0tqpn	10	15	diminished	diminish	VBN
cord-332109-ont0tqpn	10	16	.	.	.
cord-332109-ont0tqpn	11	1	Current	current	JJ
cord-332109-ont0tqpn	11	2	research	research	NN
cord-332109-ont0tqpn	11	3	on	on	IN
cord-332109-ont0tqpn	11	4	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	11	5	has	have	VBZ
cord-332109-ont0tqpn	11	6	not	not	RB
cord-332109-ont0tqpn	11	7	addressed	address	VBN
cord-332109-ont0tqpn	11	8	the	the	DT
cord-332109-ont0tqpn	11	9	unique	unique	JJ
cord-332109-ont0tqpn	11	10	challenges	challenge	NNS
cord-332109-ont0tqpn	11	11	facing	face	VBG
cord-332109-ont0tqpn	11	12	individuals	individual	NNS
cord-332109-ont0tqpn	11	13	with	with	IN
cord-332109-ont0tqpn	11	14	SUDs	sud	NNS
cord-332109-ont0tqpn	11	15	,	,	,
cord-332109-ont0tqpn	11	16	including	include	VBG
cord-332109-ont0tqpn	11	17	the	the	DT
cord-332109-ont0tqpn	11	18	heightened	heightened	JJ
cord-332109-ont0tqpn	11	19	vulnerability	vulnerability	NN
cord-332109-ont0tqpn	11	20	and	and	CC
cord-332109-ont0tqpn	11	21	susceptibility	susceptibility	NN
cord-332109-ont0tqpn	11	22	to	to	IN
cord-332109-ont0tqpn	11	23	the	the	DT
cord-332109-ont0tqpn	11	24	disease	disease	NN
cord-332109-ont0tqpn	11	25	.	.	.
cord-332109-ont0tqpn	12	1	In	in	IN
cord-332109-ont0tqpn	12	2	this	this	DT
cord-332109-ont0tqpn	12	3	systematic	systematic	JJ
cord-332109-ont0tqpn	12	4	review	review	NN
cord-332109-ont0tqpn	12	5	,	,	,
cord-332109-ont0tqpn	12	6	we	-PRON-	PRP
cord-332109-ont0tqpn	12	7	will	will	MD
cord-332109-ont0tqpn	12	8	discuss	discuss	VB
cord-332109-ont0tqpn	12	9	the	the	DT
cord-332109-ont0tqpn	12	10	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	12	11	and	and	CC
cord-332109-ont0tqpn	12	12	pathology	pathology	NN
cord-332109-ont0tqpn	12	13	of	of	IN
cord-332109-ont0tqpn	12	14	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	12	15	,	,	,
cord-332109-ont0tqpn	12	16	and	and	CC
cord-332109-ont0tqpn	12	17	highlight	highlight	VB
cord-332109-ont0tqpn	12	18	potential	potential	JJ
cord-332109-ont0tqpn	12	19	risk	risk	NN
cord-332109-ont0tqpn	12	20	factors	factor	NNS
cord-332109-ont0tqpn	12	21	and	and	CC
cord-332109-ont0tqpn	12	22	complications	complication	NNS
cord-332109-ont0tqpn	12	23	to	to	IN
cord-332109-ont0tqpn	12	24	these	these	DT
cord-332109-ont0tqpn	12	25	individuals	individual	NNS
cord-332109-ont0tqpn	12	26	.	.	.
cord-332109-ont0tqpn	13	1	We	-PRON-	PRP
cord-332109-ont0tqpn	13	2	will	will	MD
cord-332109-ont0tqpn	13	3	also	also	RB
cord-332109-ont0tqpn	13	4	provide	provide	VB
cord-332109-ont0tqpn	13	5	insights	insight	NNS
cord-332109-ont0tqpn	13	6	and	and	CC
cord-332109-ont0tqpn	13	7	considerations	consideration	NNS
cord-332109-ont0tqpn	13	8	for	for	IN
cord-332109-ont0tqpn	13	9	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	13	10	treatment	treatment	NN
cord-332109-ont0tqpn	13	11	and	and	CC
cord-332109-ont0tqpn	13	12	prevention	prevention	NN
cord-332109-ont0tqpn	13	13	in	in	IN
cord-332109-ont0tqpn	13	14	patients	patient	NNS
cord-332109-ont0tqpn	13	15	with	with	IN
cord-332109-ont0tqpn	13	16	SUDs	sud	NNS
cord-332109-ont0tqpn	13	17	.	.	.
cord-332109-ont0tqpn	14	1	The	the	DT
cord-332109-ont0tqpn	14	2	novel	novel	JJ
cord-332109-ont0tqpn	14	3	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	14	4	2019	2019	CD
cord-332109-ont0tqpn	14	5	,	,	,
cord-332109-ont0tqpn	14	6	now	now	RB
cord-332109-ont0tqpn	14	7	officially	officially	RB
cord-332109-ont0tqpn	14	8	termed	term	VBN
cord-332109-ont0tqpn	14	9	as	as	IN
cord-332109-ont0tqpn	14	10	SARS	SARS	NNP
cord-332109-ont0tqpn	14	11	-	-	HYPH
cord-332109-ont0tqpn	14	12	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	14	13	,	,	,
cord-332109-ont0tqpn	14	14	causes	cause	VBZ
cord-332109-ont0tqpn	14	15	the	the	DT
cord-332109-ont0tqpn	14	16	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	14	17	disease	disease	NN
cord-332109-ont0tqpn	14	18	2019	2019	CD
cord-332109-ont0tqpn	14	19	(	(	-LRB-
cord-332109-ont0tqpn	14	20	COVID-19	covid-19	VB
cord-332109-ont0tqpn	14	21	)	)	-RRB-
cord-332109-ont0tqpn	14	22	by	by	IN
cord-332109-ont0tqpn	14	23	infecting	infect	VBG
cord-332109-ont0tqpn	14	24	the	the	DT
cord-332109-ont0tqpn	14	25	respiratory	respiratory	JJ
cord-332109-ont0tqpn	14	26	system	system	NN
cord-332109-ont0tqpn	14	27	[	[	-LRB-
cord-332109-ont0tqpn	14	28	1	1	CD
cord-332109-ont0tqpn	14	29	]	]	-RRB-
cord-332109-ont0tqpn	14	30	.	.	.
cord-332109-ont0tqpn	15	1	The	the	DT
cord-332109-ont0tqpn	15	2	disease	disease	NN
cord-332109-ont0tqpn	15	3	was	be	VBD
cord-332109-ont0tqpn	15	4	first	first	RB
cord-332109-ont0tqpn	15	5	detected	detect	VBN
cord-332109-ont0tqpn	15	6	and	and	CC
cord-332109-ont0tqpn	15	7	reported	report	VBN
cord-332109-ont0tqpn	15	8	in	in	IN
cord-332109-ont0tqpn	15	9	Wuhan	Wuhan	NNP
cord-332109-ont0tqpn	15	10	,	,	,
cord-332109-ont0tqpn	15	11	China	China	NNP
cord-332109-ont0tqpn	15	12	,	,	,
cord-332109-ont0tqpn	15	13	in	in	IN
cord-332109-ont0tqpn	15	14	December	December	NNP
cord-332109-ont0tqpn	15	15	2019	2019	CD
cord-332109-ont0tqpn	15	16	[	[	-LRB-
cord-332109-ont0tqpn	15	17	2	2	CD
cord-332109-ont0tqpn	15	18	]	]	-RRB-
cord-332109-ont0tqpn	15	19	,	,	,
cord-332109-ont0tqpn	15	20	and	and	CC
cord-332109-ont0tqpn	15	21	has	have	VBZ
cord-332109-ont0tqpn	15	22	now	now	RB
cord-332109-ont0tqpn	15	23	spread	spread	VBN
cord-332109-ont0tqpn	15	24	to	to	IN
cord-332109-ont0tqpn	15	25	over	over	IN
cord-332109-ont0tqpn	15	26	150	150	CD
cord-332109-ont0tqpn	15	27	countries	country	NNS
cord-332109-ont0tqpn	15	28	on	on	IN
cord-332109-ont0tqpn	15	29	all	all	DT
cord-332109-ont0tqpn	15	30	continents	continent	NNS
cord-332109-ont0tqpn	15	31	except	except	IN
cord-332109-ont0tqpn	15	32	Antarctica	Antarctica	NNP
cord-332109-ont0tqpn	15	33	.	.	.
cord-332109-ont0tqpn	16	1	According	accord	VBG
cord-332109-ont0tqpn	16	2	to	to	IN
cord-332109-ont0tqpn	16	3	the	the	DT
cord-332109-ont0tqpn	16	4	World	World	NNP
cord-332109-ont0tqpn	16	5	Health	Health	NNP
cord-332109-ont0tqpn	16	6	Organization	Organization	NNP
cord-332109-ont0tqpn	16	7	(	(	-LRB-
cord-332109-ont0tqpn	16	8	WHO	who	WP
cord-332109-ont0tqpn	16	9	)	)	-RRB-
cord-332109-ont0tqpn	16	10	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	16	11	Disease	Disease	NNP
cord-332109-ont0tqpn	16	12	Dashboard	Dashboard	NNP
cord-332109-ont0tqpn	16	13	,	,	,
cord-332109-ont0tqpn	16	14	the	the	DT
cord-332109-ont0tqpn	16	15	global	global	JJ
cord-332109-ont0tqpn	16	16	tally	tally	NN
cord-332109-ont0tqpn	16	17	of	of	IN
cord-332109-ont0tqpn	16	18	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	16	19	cases	case	NNS
cord-332109-ont0tqpn	16	20	has	have	VBZ
cord-332109-ont0tqpn	16	21	approached	approach	VBN
cord-332109-ont0tqpn	16	22	13.5	13.5	CD
cord-332109-ont0tqpn	16	23	million	million	CD
cord-332109-ont0tqpn	16	24	,	,	,
cord-332109-ont0tqpn	16	25	with	with	IN
cord-332109-ont0tqpn	16	26	a	a	DT
cord-332109-ont0tqpn	16	27	death	death	NN
cord-332109-ont0tqpn	16	28	toll	toll	NN
cord-332109-ont0tqpn	16	29	of	of	IN
cord-332109-ont0tqpn	16	30	over	over	IN
cord-332109-ont0tqpn	16	31	580,000	580,000	CD
cord-332109-ont0tqpn	16	32	[	[	-LRB-
cord-332109-ont0tqpn	16	33	3	3	CD
cord-332109-ont0tqpn	16	34	]	]	-RRB-
cord-332109-ont0tqpn	16	35	at	at	IN
cord-332109-ont0tqpn	16	36	the	the	DT
cord-332109-ont0tqpn	16	37	time	time	NN
cord-332109-ont0tqpn	16	38	of	of	IN
cord-332109-ont0tqpn	16	39	writing	writing	NN
cord-332109-ont0tqpn	16	40	(	(	-LRB-
cord-332109-ont0tqpn	16	41	15	15	CD
cord-332109-ont0tqpn	16	42	July	July	NNP
cord-332109-ont0tqpn	16	43	2020	2020	CD
cord-332109-ont0tqpn	16	44	)	)	-RRB-
cord-332109-ont0tqpn	16	45	.	.	.
cord-332109-ont0tqpn	17	1	The	the	DT
cord-332109-ont0tqpn	17	2	United	United	NNP
cord-332109-ont0tqpn	17	3	States	States	NNP
cord-332109-ont0tqpn	17	4	alone	alone	RB
cord-332109-ont0tqpn	17	5	has	have	VBZ
cord-332109-ont0tqpn	17	6	counted	count	VBN
cord-332109-ont0tqpn	17	7	over	over	IN
cord-332109-ont0tqpn	17	8	3.4	3.4	CD
cord-332109-ont0tqpn	17	9	million	million	CD
cord-332109-ont0tqpn	17	10	infections	infection	NNS
cord-332109-ont0tqpn	17	11	and	and	CC
cord-332109-ont0tqpn	17	12	over	over	IN
cord-332109-ont0tqpn	17	13	131,000	131,000	CD
cord-332109-ont0tqpn	17	14	deaths	death	NNS
cord-332109-ont0tqpn	17	15	,	,	,
cord-332109-ont0tqpn	17	16	contributing	contribute	VBG
cord-332109-ont0tqpn	17	17	more	more	JJR
cord-332109-ont0tqpn	17	18	than	than	IN
cord-332109-ont0tqpn	17	19	a	a	DT
cord-332109-ont0tqpn	17	20	quarter	quarter	NN
cord-332109-ont0tqpn	17	21	of	of	IN
cord-332109-ont0tqpn	17	22	both	both	DT
cord-332109-ont0tqpn	17	23	overall	overall	JJ
cord-332109-ont0tqpn	17	24	infections	infection	NNS
cord-332109-ont0tqpn	17	25	and	and	CC
cord-332109-ont0tqpn	17	26	deaths	death	NNS
cord-332109-ont0tqpn	17	27	globally	globally	RB
cord-332109-ont0tqpn	18	1	(	(	-LRB-
cord-332109-ont0tqpn	18	2	John	John	NNP
cord-332109-ont0tqpn	18	3	Hopkins	Hopkins	NNP
cord-332109-ont0tqpn	18	4	University	University	NNP
cord-332109-ont0tqpn	18	5	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	18	6	Resource	Resource	NNP
cord-332109-ont0tqpn	18	7	Center	Center	NNP
cord-332109-ont0tqpn	18	8	)	)	-RRB-
cord-332109-ont0tqpn	19	1	[	[	-LRB-
cord-332109-ont0tqpn	19	2	4	4	CD
cord-332109-ont0tqpn	19	3	]	]	-RRB-
cord-332109-ont0tqpn	19	4	.	.	.
cord-332109-ont0tqpn	20	1	The	the	DT
cord-332109-ont0tqpn	20	2	WHO	who	WP
cord-332109-ont0tqpn	20	3	characterized	characterize	VBD
cord-332109-ont0tqpn	20	4	the	the	DT
cord-332109-ont0tqpn	20	5	COVID-19	covid-19	NN
cord-332109-ont0tqpn	20	6	as	as	IN
cord-332109-ont0tqpn	20	7	a	a	DT
cord-332109-ont0tqpn	20	8	pandemic	pandemic	NN
cord-332109-ont0tqpn	20	9	on	on	IN
cord-332109-ont0tqpn	20	10	11	11	CD
cord-332109-ont0tqpn	20	11	March	March	NNP
cord-332109-ont0tqpn	20	12	2020	2020	CD
cord-332109-ont0tqpn	20	13	[	[	-LRB-
cord-332109-ont0tqpn	20	14	5	5	CD
cord-332109-ont0tqpn	20	15	]	]	-RRB-
cord-332109-ont0tqpn	20	16	.	.	.
cord-332109-ont0tqpn	21	1	The	the	DT
cord-332109-ont0tqpn	21	2	fatality	fatality	NN
cord-332109-ont0tqpn	21	3	rate	rate	NN
cord-332109-ont0tqpn	21	4	of	of	IN
cord-332109-ont0tqpn	21	5	the	the	DT
cord-332109-ont0tqpn	21	6	disease	disease	NN
cord-332109-ont0tqpn	21	7	is	be	VBZ
cord-332109-ont0tqpn	21	8	particularly	particularly	RB
cord-332109-ont0tqpn	21	9	high	high	JJ
cord-332109-ont0tqpn	21	10	among	among	IN
cord-332109-ont0tqpn	21	11	patients	patient	NNS
cord-332109-ont0tqpn	21	12	who	who	WP
cord-332109-ont0tqpn	21	13	are	be	VBP
cord-332109-ont0tqpn	21	14	older	old	JJR
cord-332109-ont0tqpn	21	15	and	and	CC
cord-332109-ont0tqpn	21	16	who	who	WP
cord-332109-ont0tqpn	21	17	have	have	VBP
cord-332109-ont0tqpn	21	18	underlying	underlie	VBG
cord-332109-ont0tqpn	21	19	health	health	NN
cord-332109-ont0tqpn	21	20	issues	issue	NNS
cord-332109-ont0tqpn	21	21	,	,	,
cord-332109-ont0tqpn	21	22	such	such	JJ
cord-332109-ont0tqpn	21	23	as	as	IN
cord-332109-ont0tqpn	21	24	cancer	cancer	NN
cord-332109-ont0tqpn	21	25	,	,	,
cord-332109-ont0tqpn	21	26	diabetes	diabetes	NN
cord-332109-ont0tqpn	21	27	,	,	,
cord-332109-ont0tqpn	21	28	and	and	CC
cord-332109-ont0tqpn	21	29	compromised	compromise	VBN
cord-332109-ont0tqpn	21	30	lung	lung	NN
cord-332109-ont0tqpn	21	31	function	function	NN
cord-332109-ont0tqpn	21	32	or	or	CC
cord-332109-ont0tqpn	21	33	lung	lung	NN
cord-332109-ont0tqpn	21	34	disease	disease	NN
cord-332109-ont0tqpn	21	35	.	.	.
cord-332109-ont0tqpn	22	1	The	the	DT
cord-332109-ont0tqpn	22	2	United	United	NNP
cord-332109-ont0tqpn	22	3	Nations	Nations	NNP
cord-332109-ont0tqpn	22	4	(	(	-LRB-
cord-332109-ont0tqpn	22	5	UN	UN	NNP
cord-332109-ont0tqpn	22	6	)	)	-RRB-
cord-332109-ont0tqpn	22	7	reported	report	VBD
cord-332109-ont0tqpn	22	8	that	that	IN
cord-332109-ont0tqpn	22	9	35	35	CD
cord-332109-ont0tqpn	22	10	million	million	CD
cord-332109-ont0tqpn	22	11	people	people	NNS
cord-332109-ont0tqpn	22	12	worldwide	worldwide	RB
cord-332109-ont0tqpn	22	13	suffer	suffer	VBP
cord-332109-ont0tqpn	22	14	from	from	IN
cord-332109-ont0tqpn	22	15	substance	substance	NN
cord-332109-ont0tqpn	22	16	use	use	NN
cord-332109-ont0tqpn	22	17	disorders	disorder	NNS
cord-332109-ont0tqpn	22	18	(	(	-LRB-
cord-332109-ont0tqpn	22	19	SUDs	sud	NNS
cord-332109-ont0tqpn	22	20	)	)	-RRB-
cord-332109-ont0tqpn	22	21	[	[	-LRB-
cord-332109-ont0tqpn	22	22	6	6	CD
cord-332109-ont0tqpn	22	23	]	]	-RRB-
cord-332109-ont0tqpn	22	24	.	.	.
cord-332109-ont0tqpn	23	1	In	in	IN
cord-332109-ont0tqpn	23	2	the	the	DT
cord-332109-ont0tqpn	23	3	U.S.	U.S.	NNP
cord-332109-ont0tqpn	23	4	,	,	,
cord-332109-ont0tqpn	23	5	the	the	DT
cord-332109-ont0tqpn	23	6	number	number	NN
cord-332109-ont0tqpn	23	7	of	of	IN
cord-332109-ont0tqpn	23	8	individuals	individual	NNS
cord-332109-ont0tqpn	23	9	experiencing	experience	VBG
cord-332109-ont0tqpn	23	10	SUDs	sud	NNS
cord-332109-ont0tqpn	23	11	is	be	VBZ
cord-332109-ont0tqpn	23	12	20.3	20.3	CD
cord-332109-ont0tqpn	23	13	million	million	CD
cord-332109-ont0tqpn	23	14	[	[	-LRB-
cord-332109-ont0tqpn	23	15	7	7	CD
cord-332109-ont0tqpn	23	16	]	]	-RRB-
cord-332109-ont0tqpn	23	17	.	.	.
cord-332109-ont0tqpn	24	1	A	a	DT
cord-332109-ont0tqpn	24	2	large	large	JJ
cord-332109-ont0tqpn	24	3	number	number	NN
cord-332109-ont0tqpn	24	4	of	of	IN
cord-332109-ont0tqpn	24	5	individuals	individual	NNS
cord-332109-ont0tqpn	24	6	with	with	IN
cord-332109-ont0tqpn	24	7	SUDs	sud	NNS
cord-332109-ont0tqpn	24	8	have	have	VBP
cord-332109-ont0tqpn	24	9	underlying	underlying	JJ
cord-332109-ont0tqpn	24	10	health	health	NN
cord-332109-ont0tqpn	24	11	conditions	condition	NNS
cord-332109-ont0tqpn	24	12	,	,	,
cord-332109-ont0tqpn	24	13	particularly	particularly	RB
cord-332109-ont0tqpn	24	14	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	24	15	and	and	CC
cord-332109-ont0tqpn	24	16	lung	lung	NN
cord-332109-ont0tqpn	24	17	diseases	disease	NNS
cord-332109-ont0tqpn	24	18	and	and	CC
cord-332109-ont0tqpn	24	19	hepatitis	hepatitis	NN
cord-332109-ont0tqpn	24	20	C	C	NNP
cord-332109-ont0tqpn	24	21	or	or	CC
cord-332109-ont0tqpn	24	22	HIV-1	HIV-1	NNP
cord-332109-ont0tqpn	24	23	infections	infection	NNS
cord-332109-ont0tqpn	24	24	.	.	.
cord-332109-ont0tqpn	25	1	Together	together	RB
cord-332109-ont0tqpn	25	2	with	with	IN
cord-332109-ont0tqpn	25	3	complicated	complicated	JJ
cord-332109-ont0tqpn	25	4	socioeconomic	socioeconomic	JJ
cord-332109-ont0tqpn	25	5	issues	issue	NNS
cord-332109-ont0tqpn	25	6	,	,	,
cord-332109-ont0tqpn	25	7	these	these	DT
cord-332109-ont0tqpn	25	8	populations	population	NNS
cord-332109-ont0tqpn	25	9	are	be	VBP
cord-332109-ont0tqpn	25	10	particularly	particularly	RB
cord-332109-ont0tqpn	25	11	vulnerable	vulnerable	JJ
cord-332109-ont0tqpn	25	12	to	to	IN
cord-332109-ont0tqpn	25	13	COVID-19	covid-19	VB
cord-332109-ont0tqpn	25	14	[	[	-LRB-
cord-332109-ont0tqpn	25	15	8	8	CD
cord-332109-ont0tqpn	25	16	]	]	-RRB-
cord-332109-ont0tqpn	25	17	.	.	.
cord-332109-ont0tqpn	26	1	Despite	despite	IN
cord-332109-ont0tqpn	26	2	the	the	DT
cord-332109-ont0tqpn	26	3	fact	fact	NN
cord-332109-ont0tqpn	26	4	that	that	IN
cord-332109-ont0tqpn	26	5	researchers	researcher	NNS
cord-332109-ont0tqpn	26	6	and	and	CC
cord-332109-ont0tqpn	26	7	clinicians	clinician	NNS
cord-332109-ont0tqpn	26	8	around	around	IN
cord-332109-ont0tqpn	26	9	the	the	DT
cord-332109-ont0tqpn	26	10	world	world	NN
cord-332109-ont0tqpn	26	11	have	have	VBP
cord-332109-ont0tqpn	26	12	collected	collect	VBN
cord-332109-ont0tqpn	26	13	and	and	CC
cord-332109-ont0tqpn	26	14	disseminated	disseminate	VBN
cord-332109-ont0tqpn	26	15	tremendous	tremendous	JJ
cord-332109-ont0tqpn	26	16	amounts	amount	NNS
cord-332109-ont0tqpn	26	17	of	of	IN
cord-332109-ont0tqpn	26	18	data	datum	NNS
cord-332109-ont0tqpn	26	19	on	on	IN
cord-332109-ont0tqpn	26	20	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	26	21	,	,	,
cord-332109-ont0tqpn	26	22	we	-PRON-	PRP
cord-332109-ont0tqpn	26	23	have	have	VBP
cord-332109-ont0tqpn	26	24	very	very	RB
cord-332109-ont0tqpn	26	25	little	little	JJ
cord-332109-ont0tqpn	26	26	knowledge	knowledge	NN
cord-332109-ont0tqpn	26	27	of	of	IN
cord-332109-ont0tqpn	26	28	the	the	DT
cord-332109-ont0tqpn	26	29	interactions	interaction	NNS
cord-332109-ont0tqpn	26	30	and	and	CC
cord-332109-ont0tqpn	26	31	comorbidity	comorbidity	NN
cord-332109-ont0tqpn	26	32	of	of	IN
cord-332109-ont0tqpn	26	33	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	26	34	and	and	CC
cord-332109-ont0tqpn	26	35	SUD	SUD	NNP
cord-332109-ont0tqpn	26	36	.	.	.
cord-332109-ont0tqpn	27	1	In	in	IN
cord-332109-ont0tqpn	27	2	this	this	DT
cord-332109-ont0tqpn	27	3	review	review	NN
cord-332109-ont0tqpn	27	4	,	,	,
cord-332109-ont0tqpn	27	5	we	-PRON-	PRP
cord-332109-ont0tqpn	27	6	will	will	MD
cord-332109-ont0tqpn	27	7	analyze	analyze	VB
cord-332109-ont0tqpn	27	8	relevant	relevant	JJ
cord-332109-ont0tqpn	27	9	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	27	10	and	and	CC
cord-332109-ont0tqpn	27	11	SUD	SUD	NNP
cord-332109-ont0tqpn	27	12	literatures	literature	NNS
cord-332109-ont0tqpn	27	13	,	,	,
cord-332109-ont0tqpn	27	14	and	and	CC
cord-332109-ont0tqpn	27	15	highlight	highlight	VB
cord-332109-ont0tqpn	27	16	the	the	DT
cord-332109-ont0tqpn	27	17	susceptibilities	susceptibility	NNS
cord-332109-ont0tqpn	27	18	and	and	CC
cord-332109-ont0tqpn	27	19	vulnerabilities	vulnerability	NNS
cord-332109-ont0tqpn	27	20	for	for	IN
cord-332109-ont0tqpn	27	21	individuals	individual	NNS
cord-332109-ont0tqpn	27	22	with	with	IN
cord-332109-ont0tqpn	27	23	SUD	SUD	NNP
cord-332109-ont0tqpn	27	24	.	.	.
cord-332109-ont0tqpn	28	1	Similar	similar	JJ
cord-332109-ont0tqpn	28	2	to	to	IN
cord-332109-ont0tqpn	28	3	SARS	SARS	NNP
cord-332109-ont0tqpn	28	4	-	-	HYPH
cord-332109-ont0tqpn	28	5	CoV	CoV	NNP
cord-332109-ont0tqpn	28	6	,	,	,
cord-332109-ont0tqpn	28	7	SARS	SARS	NNP
cord-332109-ont0tqpn	28	8	-	-	HYPH
cord-332109-ont0tqpn	28	9	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	28	10	recognizes	recognize	VBZ
cord-332109-ont0tqpn	28	11	the	the	DT
cord-332109-ont0tqpn	28	12	angiotensin	angiotensin	NN
cord-332109-ont0tqpn	28	13	converting	convert	VBG
cord-332109-ont0tqpn	28	14	enzyme	enzyme	NN
cord-332109-ont0tqpn	28	15	2	2	CD
cord-332109-ont0tqpn	28	16	(	(	-LRB-
cord-332109-ont0tqpn	28	17	ACE2	ACE2	NNP
cord-332109-ont0tqpn	28	18	)	)	-RRB-
cord-332109-ont0tqpn	28	19	receptor	receptor	NN
cord-332109-ont0tqpn	28	20	by	by	IN
cord-332109-ont0tqpn	28	21	its	-PRON-	PRP$
cord-332109-ont0tqpn	28	22	S	S	NNP
cord-332109-ont0tqpn	28	23	protein	protein	NN
cord-332109-ont0tqpn	28	24	and	and	CC
cord-332109-ont0tqpn	28	25	utilizes	utilize	VBZ
cord-332109-ont0tqpn	28	26	it	-PRON-	PRP
cord-332109-ont0tqpn	28	27	for	for	IN
cord-332109-ont0tqpn	28	28	cell	cell	NN
cord-332109-ont0tqpn	28	29	entry	entry	NN
cord-332109-ont0tqpn	28	30	[	[	-LRB-
cord-332109-ont0tqpn	28	31	20	20	CD
cord-332109-ont0tqpn	28	32	,	,	,
cord-332109-ont0tqpn	28	33	22	22	CD
cord-332109-ont0tqpn	28	34	]	]	-RRB-
cord-332109-ont0tqpn	28	35	.	.	.
cord-332109-ont0tqpn	29	1	The	the	DT
cord-332109-ont0tqpn	29	2	heavily	heavily	RB
cord-332109-ont0tqpn	29	3	glycosylated	glycosylated	JJ
cord-332109-ont0tqpn	29	4	S	S	NNP
cord-332109-ont0tqpn	29	5	protein	protein	NN
cord-332109-ont0tqpn	29	6	triggers	trigger	VBZ
cord-332109-ont0tqpn	29	7	virus	virus	NN
cord-332109-ont0tqpn	29	8	cell	cell	NN
cord-332109-ont0tqpn	29	9	entry	entry	NN
cord-332109-ont0tqpn	29	10	by	by	IN
cord-332109-ont0tqpn	29	11	fusing	fuse	VBG
cord-332109-ont0tqpn	29	12	the	the	DT
cord-332109-ont0tqpn	29	13	receptor	receptor	NN
cord-332109-ont0tqpn	29	14	binding	bind	VBG
cord-332109-ont0tqpn	29	15	domain	domain	NN
cord-332109-ont0tqpn	29	16	(	(	-LRB-
cord-332109-ont0tqpn	29	17	RBD	RBD	NNP
cord-332109-ont0tqpn	29	18	)	)	-RRB-
cord-332109-ont0tqpn	29	19	on	on	IN
cord-332109-ont0tqpn	29	20	the	the	DT
cord-332109-ont0tqpn	29	21	S1	s1	NN
cord-332109-ont0tqpn	29	22	subunit	subunit	NN
cord-332109-ont0tqpn	29	23	to	to	IN
cord-332109-ont0tqpn	29	24	the	the	DT
cord-332109-ont0tqpn	29	25	host	host	NN
cord-332109-ont0tqpn	29	26	ACE2	ACE2	NNP
cord-332109-ont0tqpn	29	27	receptor	receptor	NN
cord-332109-ont0tqpn	29	28	,	,	,
cord-332109-ont0tqpn	29	29	engaging	engage	VBG
cord-332109-ont0tqpn	29	30	the	the	DT
cord-332109-ont0tqpn	29	31	transition	transition	NN
cord-332109-ont0tqpn	29	32	of	of	IN
cord-332109-ont0tqpn	29	33	S2	S2	NNP
cord-332109-ont0tqpn	29	34	subunit	subunit	NN
cord-332109-ont0tqpn	29	35	to	to	IN
cord-332109-ont0tqpn	29	36	a	a	DT
cord-332109-ont0tqpn	29	37	stable	stable	JJ
cord-332109-ont0tqpn	29	38	post	post	JJ
cord-332109-ont0tqpn	29	39	-	-	JJ
cord-332109-ont0tqpn	29	40	fusion	fusion	JJ
cord-332109-ont0tqpn	29	41	conformation	conformation	NN
cord-332109-ont0tqpn	29	42	[	[	-LRB-
cord-332109-ont0tqpn	29	43	23	23	CD
cord-332109-ont0tqpn	29	44	]	]	-RRB-
cord-332109-ont0tqpn	29	45	.	.	.
cord-332109-ont0tqpn	30	1	Cryoelectron	Cryoelectron	NNP
cord-332109-ont0tqpn	30	2	microscopy	microscopy	NNS
cord-332109-ont0tqpn	30	3	(	(	-LRB-
cord-332109-ont0tqpn	30	4	EM	EM	NNP
cord-332109-ont0tqpn	30	5	)	)	-RRB-
cord-332109-ont0tqpn	30	6	structures	structure	NNS
cord-332109-ont0tqpn	30	7	of	of	IN
cord-332109-ont0tqpn	30	8	the	the	DT
cord-332109-ont0tqpn	30	9	pre	pre	JJ
cord-332109-ont0tqpn	30	10	-	-	JJ
cord-332109-ont0tqpn	30	11	fusion	fusion	JJ
cord-332109-ont0tqpn	30	12	[	[	-LRB-
cord-332109-ont0tqpn	30	13	23	23	CD
cord-332109-ont0tqpn	30	14	]	]	-RRB-
cord-332109-ont0tqpn	30	15	and	and	CC
cord-332109-ont0tqpn	30	16	post	post	JJ
cord-332109-ont0tqpn	30	17	-	-	JJ
cord-332109-ont0tqpn	30	18	fusion	fusion	JJ
cord-332109-ont0tqpn	30	19	structures	structure	NNS
cord-332109-ont0tqpn	30	20	[	[	-LRB-
cord-332109-ont0tqpn	30	21	24	24	CD
cord-332109-ont0tqpn	30	22	]	]	-RRB-
cord-332109-ont0tqpn	30	23	of	of	IN
cord-332109-ont0tqpn	30	24	the	the	DT
cord-332109-ont0tqpn	30	25	S	S	NNP
cord-332109-ont0tqpn	30	26	protein	protein	NN
cord-332109-ont0tqpn	30	27	have	have	VBP
cord-332109-ont0tqpn	30	28	been	be	VBN
cord-332109-ont0tqpn	30	29	reported	report	VBN
cord-332109-ont0tqpn	30	30	.	.	.
cord-332109-ont0tqpn	31	1	The	the	DT
cord-332109-ont0tqpn	31	2	SARS	SARS	NNP
cord-332109-ont0tqpn	31	3	-	-	HYPH
cord-332109-ont0tqpn	31	4	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	31	5	S	S	NNP
cord-332109-ont0tqpn	31	6	protein	protein	NN
cord-332109-ont0tqpn	31	7	has	have	VBZ
cord-332109-ont0tqpn	31	8	been	be	VBN
cord-332109-ont0tqpn	31	9	shown	show	VBN
cord-332109-ont0tqpn	31	10	to	to	TO
cord-332109-ont0tqpn	31	11	have	have	VB
cord-332109-ont0tqpn	31	12	a	a	DT
cord-332109-ont0tqpn	31	13	much	much	RB
cord-332109-ont0tqpn	31	14	higher	high	JJR
cord-332109-ont0tqpn	31	15	binding	bind	VBG
cord-332109-ont0tqpn	31	16	affinity	affinity	NN
cord-332109-ont0tqpn	31	17	to	to	IN
cord-332109-ont0tqpn	31	18	the	the	DT
cord-332109-ont0tqpn	31	19	ACE2	ACE2	NNP
cord-332109-ont0tqpn	31	20	than	than	IN
cord-332109-ont0tqpn	31	21	the	the	DT
cord-332109-ont0tqpn	31	22	SARS	SARS	NNP
cord-332109-ont0tqpn	31	23	-	-	HYPH
cord-332109-ont0tqpn	31	24	CoV	CoV	NNP
cord-332109-ont0tqpn	31	25	S	S	NNP
cord-332109-ont0tqpn	31	26	protein	protein	NN
cord-332109-ont0tqpn	31	27	[	[	-LRB-
cord-332109-ont0tqpn	31	28	23	23	CD
cord-332109-ont0tqpn	31	29	,	,	,
cord-332109-ont0tqpn	31	30	25	25	CD
cord-332109-ont0tqpn	31	31	]	]	-RRB-
cord-332109-ont0tqpn	31	32	.	.	.
cord-332109-ont0tqpn	32	1	The	the	DT
cord-332109-ont0tqpn	32	2	S	S	NNP
cord-332109-ont0tqpn	32	3	protein	protein	NN
cord-332109-ont0tqpn	32	4	contains	contain	VBZ
cord-332109-ont0tqpn	32	5	22	22	CD
cord-332109-ont0tqpn	32	6	N	n	CD
cord-332109-ont0tqpn	32	7	-	-	HYPH
cord-332109-ont0tqpn	32	8	linked	link	VBN
cord-332109-ont0tqpn	32	9	glycans	glycan	NNS
cord-332109-ont0tqpn	32	10	,	,	,
cord-332109-ont0tqpn	32	11	and	and	CC
cord-332109-ont0tqpn	32	12	the	the	DT
cord-332109-ont0tqpn	32	13	complex	complex	JJ
cord-332109-ont0tqpn	32	14	glycosylation	glycosylation	NN
cord-332109-ont0tqpn	32	15	is	be	VBZ
cord-332109-ont0tqpn	32	16	likely	likely	JJ
cord-332109-ont0tqpn	32	17	to	to	TO
cord-332109-ont0tqpn	32	18	play	play	VB
cord-332109-ont0tqpn	32	19	a	a	DT
cord-332109-ont0tqpn	32	20	role	role	NN
cord-332109-ont0tqpn	32	21	in	in	IN
cord-332109-ont0tqpn	32	22	shielding	shielding	NN
cord-332109-ont0tqpn	32	23	and	and	CC
cord-332109-ont0tqpn	32	24	camouflaging	camouflage	VBG
cord-332109-ont0tqpn	32	25	for	for	IN
cord-332109-ont0tqpn	32	26	immune	immune	JJ
cord-332109-ont0tqpn	32	27	evasion	evasion	NN
cord-332109-ont0tqpn	32	28	of	of	IN
cord-332109-ont0tqpn	32	29	the	the	DT
cord-332109-ont0tqpn	32	30	virus	virus	NN
cord-332109-ont0tqpn	32	31	[	[	-LRB-
cord-332109-ont0tqpn	32	32	26	26	CD
cord-332109-ont0tqpn	32	33	,	,	,
cord-332109-ont0tqpn	32	34	27	27	CD
cord-332109-ont0tqpn	32	35	]	]	-RRB-
cord-332109-ont0tqpn	32	36	.	.	.
cord-332109-ont0tqpn	33	1	The	the	DT
cord-332109-ont0tqpn	33	2	S	S	NNP
cord-332109-ont0tqpn	33	3	protein	protein	NN
cord-332109-ont0tqpn	33	4	is	be	VBZ
cord-332109-ont0tqpn	33	5	activated	activate	VBN
cord-332109-ont0tqpn	33	6	by	by	IN
cord-332109-ont0tqpn	33	7	type	type	NN
cord-332109-ont0tqpn	33	8	II	II	NNP
cord-332109-ont0tqpn	33	9	transmembrane	transmembrane	NN
cord-332109-ont0tqpn	33	10	serine	serine	NN
cord-332109-ont0tqpn	33	11	protease	protease	NN
cord-332109-ont0tqpn	33	12	(	(	-LRB-
cord-332109-ont0tqpn	33	13	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	33	14	)	)	-RRB-
cord-332109-ont0tqpn	33	15	,	,	.
cord-332109-ont0tqpn	34	1	a	a	DT
cord-332109-ont0tqpn	34	2	host	host	NN
cord-332109-ont0tqpn	34	3	protease	protease	NN
cord-332109-ont0tqpn	34	4	co	co	NN
cord-332109-ont0tqpn	34	5	-	-	VBD
cord-332109-ont0tqpn	34	6	expressed	express	VBN
cord-332109-ont0tqpn	34	7	with	with	IN
cord-332109-ont0tqpn	34	8	ACE2	ACE2	NNP
cord-332109-ont0tqpn	34	9	on	on	IN
cord-332109-ont0tqpn	34	10	the	the	DT
cord-332109-ont0tqpn	34	11	cell	cell	NN
cord-332109-ont0tqpn	34	12	surface	surface	NN
cord-332109-ont0tqpn	34	13	[	[	-LRB-
cord-332109-ont0tqpn	34	14	24	24	CD
cord-332109-ont0tqpn	34	15	,	,	,
cord-332109-ont0tqpn	34	16	28	28	CD
cord-332109-ont0tqpn	34	17	]	]	-RRB-
cord-332109-ont0tqpn	34	18	.	.	.
cord-332109-ont0tqpn	35	1	In	in	IN
cord-332109-ont0tqpn	35	2	cells	cell	NNS
cord-332109-ont0tqpn	35	3	not	not	RB
cord-332109-ont0tqpn	35	4	expressing	express	VBG
cord-332109-ont0tqpn	35	5	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	35	6	,	,	,
cord-332109-ont0tqpn	35	7	other	other	JJ
cord-332109-ont0tqpn	35	8	proteases	protease	NNS
cord-332109-ont0tqpn	35	9	,	,	,
cord-332109-ont0tqpn	35	10	such	such	JJ
cord-332109-ont0tqpn	35	11	as	as	IN
cord-332109-ont0tqpn	35	12	cathepsin	cathepsin	NN
cord-332109-ont0tqpn	35	13	B	B	NNP
cord-332109-ont0tqpn	35	14	/	/	SYM
cord-332109-ont0tqpn	35	15	L	L	NNP
cord-332109-ont0tqpn	35	16	,	,	,
cord-332109-ont0tqpn	35	17	may	may	MD
cord-332109-ont0tqpn	35	18	activate	activate	VB
cord-332109-ont0tqpn	35	19	the	the	DT
cord-332109-ont0tqpn	35	20	S	S	NNP
cord-332109-ont0tqpn	35	21	protein	protein	NN
cord-332109-ont0tqpn	35	22	and	and	CC
cord-332109-ont0tqpn	35	23	facilitate	facilitate	VB
cord-332109-ont0tqpn	35	24	viral	viral	JJ
cord-332109-ont0tqpn	35	25	entry	entry	NN
cord-332109-ont0tqpn	35	26	[	[	-LRB-
cord-332109-ont0tqpn	35	27	29	29	CD
cord-332109-ont0tqpn	35	28	]	]	-RRB-
cord-332109-ont0tqpn	35	29	.	.	.
cord-332109-ont0tqpn	36	1	Upon	upon	IN
cord-332109-ont0tqpn	36	2	cell	cell	NN
cord-332109-ont0tqpn	36	3	entry	entry	NN
cord-332109-ont0tqpn	36	4	,	,	,
cord-332109-ont0tqpn	36	5	SARS	SARS	NNP
cord-332109-ont0tqpn	36	6	-	-	HYPH
cord-332109-ont0tqpn	36	7	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	36	8	has	have	VBZ
cord-332109-ont0tqpn	36	9	a	a	DT
cord-332109-ont0tqpn	36	10	similar	similar	JJ
cord-332109-ont0tqpn	36	11	life	life	NN
cord-332109-ont0tqpn	36	12	cycle	cycle	NN
cord-332109-ont0tqpn	36	13	and	and	CC
cord-332109-ont0tqpn	36	14	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	36	15	as	as	IN
cord-332109-ont0tqpn	36	16	other	other	JJ
cord-332109-ont0tqpn	36	17	β	β	NN
cord-332109-ont0tqpn	36	18	-	-	HYPH
cord-332109-ont0tqpn	36	19	coronaviruses	coronaviruse	NNS
cord-332109-ont0tqpn	36	20	,	,	,
cord-332109-ont0tqpn	36	21	including	include	VBG
cord-332109-ont0tqpn	36	22	SARS	SARS	NNP
cord-332109-ont0tqpn	36	23	-	-	HYPH
cord-332109-ont0tqpn	36	24	CoV	CoV	NNP
cord-332109-ont0tqpn	36	25	and	and	CC
cord-332109-ont0tqpn	36	26	MERS	MERS	NNP
cord-332109-ont0tqpn	36	27	-	-	HYPH
cord-332109-ont0tqpn	36	28	CoV	CoV	NNP
cord-332109-ont0tqpn	36	29	[	[	-LRB-
cord-332109-ont0tqpn	36	30	30	30	CD
cord-332109-ont0tqpn	36	31	]	]	-RRB-
cord-332109-ont0tqpn	36	32	.	.	.
cord-332109-ont0tqpn	37	1	Upon	upon	IN
cord-332109-ont0tqpn	37	2	ACE2	ACE2	NNP
cord-332109-ont0tqpn	37	3	receptor	receptor	NN
cord-332109-ont0tqpn	37	4	binding	binding	NN
cord-332109-ont0tqpn	37	5	,	,	,
cord-332109-ont0tqpn	37	6	the	the	DT
cord-332109-ont0tqpn	37	7	virus	virus	NN
cord-332109-ont0tqpn	37	8	fuses	fuse	VBZ
cord-332109-ont0tqpn	37	9	its	-PRON-	PRP$
cord-332109-ont0tqpn	37	10	membrane	membrane	NN
cord-332109-ont0tqpn	37	11	with	with	IN
cord-332109-ont0tqpn	37	12	the	the	DT
cord-332109-ont0tqpn	37	13	host	host	NN
cord-332109-ont0tqpn	37	14	cell	cell	NN
cord-332109-ont0tqpn	37	15	plasma	plasma	NN
cord-332109-ont0tqpn	37	16	membrane	membrane	NN
cord-332109-ont0tqpn	37	17	,	,	,
cord-332109-ont0tqpn	37	18	releasing	release	VBG
cord-332109-ont0tqpn	37	19	its	-PRON-	PRP$
cord-332109-ont0tqpn	37	20	genomic	genomic	JJ
cord-332109-ont0tqpn	37	21	RNA	rna	NN
cord-332109-ont0tqpn	37	22	into	into	IN
cord-332109-ont0tqpn	37	23	the	the	DT
cord-332109-ont0tqpn	37	24	cytoplasm	cytoplasm	NN
cord-332109-ont0tqpn	37	25	.	.	.
cord-332109-ont0tqpn	38	1	Since	since	IN
cord-332109-ont0tqpn	38	2	the	the	DT
cord-332109-ont0tqpn	38	3	viral	viral	JJ
cord-332109-ont0tqpn	38	4	RNA	RNA	NNP
cord-332109-ont0tqpn	38	5	is	be	VBZ
cord-332109-ont0tqpn	38	6	similar	similar	JJ
cord-332109-ont0tqpn	38	7	to	to	IN
cord-332109-ont0tqpn	38	8	the	the	DT
cord-332109-ont0tqpn	38	9	human	human	JJ
cord-332109-ont0tqpn	38	10	messenger	messenger	NN
cord-332109-ont0tqpn	38	11	RNA	RNA	NNP
cord-332109-ont0tqpn	38	12	(	(	-LRB-
cord-332109-ont0tqpn	38	13	mRNA	mRNA	NNP
cord-332109-ont0tqpn	38	14	)	)	-RRB-
cord-332109-ont0tqpn	38	15	,	,	,
cord-332109-ont0tqpn	38	16	it	-PRON-	PRP
cord-332109-ont0tqpn	38	17	triggers	trigger	VBZ
cord-332109-ont0tqpn	38	18	the	the	DT
cord-332109-ont0tqpn	38	19	host	host	NN
cord-332109-ont0tqpn	38	20	ribosome	ribosome	NN
cord-332109-ont0tqpn	38	21	to	to	TO
cord-332109-ont0tqpn	38	22	start	start	VB
cord-332109-ont0tqpn	38	23	translating	translate	VBG
cord-332109-ont0tqpn	38	24	the	the	DT
cord-332109-ont0tqpn	38	25	viral	viral	JJ
cord-332109-ont0tqpn	38	26	RNA	RNA	NNP
cord-332109-ont0tqpn	38	27	and	and	CC
cord-332109-ont0tqpn	38	28	producing	produce	VBG
cord-332109-ont0tqpn	38	29	viral	viral	JJ
cord-332109-ont0tqpn	38	30	proteins	protein	NNS
cord-332109-ont0tqpn	38	31	.	.	.
cord-332109-ont0tqpn	39	1	The	the	DT
cord-332109-ont0tqpn	39	2	viral	viral	JJ
cord-332109-ont0tqpn	39	3	replicase	replicase	NN
cord-332109-ont0tqpn	39	4	ORF	ORF	NNP
cord-332109-ont0tqpn	39	5	is	be	VBZ
cord-332109-ont0tqpn	39	6	translated	translate	VBN
cord-332109-ont0tqpn	39	7	into	into	IN
cord-332109-ont0tqpn	39	8	two	two	CD
cord-332109-ont0tqpn	39	9	overlapping	overlap	VBG
cord-332109-ont0tqpn	39	10	polyproteins	polyprotein	NNS
cord-332109-ont0tqpn	39	11	,	,	,
cord-332109-ont0tqpn	39	12	PP1a	PP1a	NNP
cord-332109-ont0tqpn	39	13	(	(	-LRB-
cord-332109-ont0tqpn	39	14	NSP1	NSP1	NNP
cord-332109-ont0tqpn	39	15	-	-	HYPH
cord-332109-ont0tqpn	39	16	11	11	CD
cord-332109-ont0tqpn	39	17	)	)	-RRB-
cord-332109-ont0tqpn	39	18	and	and	CC
cord-332109-ont0tqpn	39	19	PP1ab	PP1ab	NNP
cord-332109-ont0tqpn	39	20	(	(	-LRB-
cord-332109-ont0tqpn	39	21	NSP1	NSP1	NNP
cord-332109-ont0tqpn	39	22	-	-	HYPH
cord-332109-ont0tqpn	39	23	16	16	CD
cord-332109-ont0tqpn	39	24	)	)	-RRB-
cord-332109-ont0tqpn	39	25	,	,	,
cord-332109-ont0tqpn	39	26	which	which	WDT
cord-332109-ont0tqpn	39	27	require	require	VBP
cord-332109-ont0tqpn	39	28	extensive	extensive	JJ
cord-332109-ont0tqpn	39	29	processing	processing	NN
cord-332109-ont0tqpn	39	30	.	.	.
cord-332109-ont0tqpn	40	1	NSP5	NSP5	NNP
cord-332109-ont0tqpn	40	2	,	,	,
cord-332109-ont0tqpn	40	3	the	the	DT
cord-332109-ont0tqpn	40	4	33.8-kDa	33.8-kda	CD
cord-332109-ont0tqpn	40	5	main	main	JJ
cord-332109-ont0tqpn	40	6	viral	viral	JJ
cord-332109-ont0tqpn	40	7	protease	protease	NN
cord-332109-ont0tqpn	40	8	(	(	-LRB-
cord-332109-ont0tqpn	40	9	M	M	NNP
cord-332109-ont0tqpn	40	10	pro	pro	FW
cord-332109-ont0tqpn	40	11	)	)	-RRB-
cord-332109-ont0tqpn	40	12	,	,	,
cord-332109-ont0tqpn	40	13	also	also	RB
cord-332109-ont0tqpn	40	14	referred	refer	VBD
cord-332109-ont0tqpn	40	15	to	to	IN
cord-332109-ont0tqpn	40	16	as	as	IN
cord-332109-ont0tqpn	40	17	the	the	DT
cord-332109-ont0tqpn	40	18	3-chymotrypsin	3-chymotrypsin	CD
cord-332109-ont0tqpn	40	19	-	-	HYPH
cord-332109-ont0tqpn	40	20	like	like	JJ
cord-332109-ont0tqpn	40	21	protease	protease	NN
cord-332109-ont0tqpn	40	22	(	(	-LRB-
cord-332109-ont0tqpn	40	23	3CL	3CL	NNP
cord-332109-ont0tqpn	40	24	pro	pro	JJ
cord-332109-ont0tqpn	40	25	)	)	-RRB-
cord-332109-ont0tqpn	40	26	,	,	,
cord-332109-ont0tqpn	40	27	performs	perform	VBZ
cord-332109-ont0tqpn	40	28	the	the	DT
cord-332109-ont0tqpn	40	29	function	function	NN
cord-332109-ont0tqpn	40	30	by	by	IN
cord-332109-ont0tqpn	40	31	autolytic	autolytic	JJ
cord-332109-ont0tqpn	40	32	cleavage	cleavage	NN
cord-332109-ont0tqpn	40	33	of	of	IN
cord-332109-ont0tqpn	40	34	the	the	DT
cord-332109-ont0tqpn	40	35	protease	protease	NN
cord-332109-ont0tqpn	40	36	itself	-PRON-	PRP
cord-332109-ont0tqpn	40	37	,	,	,
cord-332109-ont0tqpn	40	38	and	and	CC
cord-332109-ont0tqpn	40	39	then	then	RB
cord-332109-ont0tqpn	40	40	subsequently	subsequently	RB
cord-332109-ont0tqpn	40	41	Similar	similar	JJ
cord-332109-ont0tqpn	40	42	to	to	IN
cord-332109-ont0tqpn	40	43	SARS	SARS	NNP
cord-332109-ont0tqpn	40	44	-	-	HYPH
cord-332109-ont0tqpn	40	45	CoV	CoV	NNP
cord-332109-ont0tqpn	40	46	,	,	,
cord-332109-ont0tqpn	40	47	SARS	SARS	NNP
cord-332109-ont0tqpn	40	48	-	-	HYPH
cord-332109-ont0tqpn	40	49	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	40	50	recognizes	recognize	VBZ
cord-332109-ont0tqpn	40	51	the	the	DT
cord-332109-ont0tqpn	40	52	angiotensin	angiotensin	NN
cord-332109-ont0tqpn	40	53	converting	convert	VBG
cord-332109-ont0tqpn	40	54	enzyme	enzyme	NN
cord-332109-ont0tqpn	40	55	2	2	CD
cord-332109-ont0tqpn	40	56	(	(	-LRB-
cord-332109-ont0tqpn	40	57	ACE2	ACE2	NNP
cord-332109-ont0tqpn	40	58	)	)	-RRB-
cord-332109-ont0tqpn	40	59	receptor	receptor	NN
cord-332109-ont0tqpn	40	60	by	by	IN
cord-332109-ont0tqpn	40	61	its	-PRON-	PRP$
cord-332109-ont0tqpn	40	62	S	S	NNP
cord-332109-ont0tqpn	40	63	protein	protein	NN
cord-332109-ont0tqpn	40	64	and	and	CC
cord-332109-ont0tqpn	40	65	utilizes	utilize	VBZ
cord-332109-ont0tqpn	40	66	it	-PRON-	PRP
cord-332109-ont0tqpn	40	67	for	for	IN
cord-332109-ont0tqpn	40	68	cell	cell	NN
cord-332109-ont0tqpn	40	69	entry	entry	NN
cord-332109-ont0tqpn	40	70	[	[	-LRB-
cord-332109-ont0tqpn	40	71	20	20	CD
cord-332109-ont0tqpn	40	72	,	,	,
cord-332109-ont0tqpn	40	73	22	22	CD
cord-332109-ont0tqpn	40	74	]	]	-RRB-
cord-332109-ont0tqpn	40	75	.	.	.
cord-332109-ont0tqpn	41	1	The	the	DT
cord-332109-ont0tqpn	41	2	heavily	heavily	RB
cord-332109-ont0tqpn	41	3	glycosylated	glycosylated	JJ
cord-332109-ont0tqpn	41	4	S	S	NNP
cord-332109-ont0tqpn	41	5	protein	protein	NN
cord-332109-ont0tqpn	41	6	triggers	trigger	VBZ
cord-332109-ont0tqpn	41	7	virus	virus	NN
cord-332109-ont0tqpn	41	8	cell	cell	NN
cord-332109-ont0tqpn	41	9	entry	entry	NN
cord-332109-ont0tqpn	41	10	by	by	IN
cord-332109-ont0tqpn	41	11	fusing	fuse	VBG
cord-332109-ont0tqpn	41	12	the	the	DT
cord-332109-ont0tqpn	41	13	receptor	receptor	NN
cord-332109-ont0tqpn	41	14	binding	bind	VBG
cord-332109-ont0tqpn	41	15	domain	domain	NN
cord-332109-ont0tqpn	41	16	(	(	-LRB-
cord-332109-ont0tqpn	41	17	RBD	RBD	NNP
cord-332109-ont0tqpn	41	18	)	)	-RRB-
cord-332109-ont0tqpn	41	19	on	on	IN
cord-332109-ont0tqpn	41	20	the	the	DT
cord-332109-ont0tqpn	41	21	S1	s1	NN
cord-332109-ont0tqpn	41	22	subunit	subunit	NN
cord-332109-ont0tqpn	41	23	to	to	IN
cord-332109-ont0tqpn	41	24	the	the	DT
cord-332109-ont0tqpn	41	25	host	host	NN
cord-332109-ont0tqpn	41	26	ACE2	ACE2	NNP
cord-332109-ont0tqpn	41	27	receptor	receptor	NN
cord-332109-ont0tqpn	41	28	,	,	,
cord-332109-ont0tqpn	41	29	engaging	engage	VBG
cord-332109-ont0tqpn	41	30	the	the	DT
cord-332109-ont0tqpn	41	31	transition	transition	NN
cord-332109-ont0tqpn	41	32	of	of	IN
cord-332109-ont0tqpn	41	33	S2	S2	NNP
cord-332109-ont0tqpn	41	34	subunit	subunit	NN
cord-332109-ont0tqpn	41	35	to	to	IN
cord-332109-ont0tqpn	41	36	a	a	DT
cord-332109-ont0tqpn	41	37	stable	stable	JJ
cord-332109-ont0tqpn	41	38	post	post	JJ
cord-332109-ont0tqpn	41	39	-	-	JJ
cord-332109-ont0tqpn	41	40	fusion	fusion	JJ
cord-332109-ont0tqpn	41	41	conformation	conformation	NN
cord-332109-ont0tqpn	41	42	[	[	-LRB-
cord-332109-ont0tqpn	41	43	23	23	CD
cord-332109-ont0tqpn	41	44	]	]	-RRB-
cord-332109-ont0tqpn	41	45	.	.	.
cord-332109-ont0tqpn	42	1	Cryo	cryo	NN
cord-332109-ont0tqpn	42	2	-	-	HYPH
cord-332109-ont0tqpn	42	3	electron	electron	NN
cord-332109-ont0tqpn	42	4	microscopy	microscopy	NN
cord-332109-ont0tqpn	42	5	(	(	-LRB-
cord-332109-ont0tqpn	42	6	EM	EM	NNP
cord-332109-ont0tqpn	42	7	)	)	-RRB-
cord-332109-ont0tqpn	42	8	structures	structure	NNS
cord-332109-ont0tqpn	42	9	of	of	IN
cord-332109-ont0tqpn	42	10	the	the	DT
cord-332109-ont0tqpn	42	11	pre	pre	JJ
cord-332109-ont0tqpn	42	12	-	-	JJ
cord-332109-ont0tqpn	42	13	fusion	fusion	JJ
cord-332109-ont0tqpn	42	14	[	[	-LRB-
cord-332109-ont0tqpn	42	15	23	23	CD
cord-332109-ont0tqpn	42	16	]	]	-RRB-
cord-332109-ont0tqpn	42	17	and	and	CC
cord-332109-ont0tqpn	42	18	post	post	JJ
cord-332109-ont0tqpn	42	19	-	-	JJ
cord-332109-ont0tqpn	42	20	fusion	fusion	JJ
cord-332109-ont0tqpn	42	21	structures	structure	NNS
cord-332109-ont0tqpn	42	22	[	[	-LRB-
cord-332109-ont0tqpn	42	23	24	24	CD
cord-332109-ont0tqpn	42	24	]	]	-RRB-
cord-332109-ont0tqpn	42	25	of	of	IN
cord-332109-ont0tqpn	42	26	the	the	DT
cord-332109-ont0tqpn	42	27	S	S	NNP
cord-332109-ont0tqpn	42	28	protein	protein	NN
cord-332109-ont0tqpn	42	29	have	have	VBP
cord-332109-ont0tqpn	42	30	been	be	VBN
cord-332109-ont0tqpn	42	31	reported	report	VBN
cord-332109-ont0tqpn	42	32	.	.	.
cord-332109-ont0tqpn	43	1	The	the	DT
cord-332109-ont0tqpn	43	2	SARS	SARS	NNP
cord-332109-ont0tqpn	43	3	-	-	HYPH
cord-332109-ont0tqpn	43	4	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	43	5	S	S	NNP
cord-332109-ont0tqpn	43	6	protein	protein	NN
cord-332109-ont0tqpn	43	7	has	have	VBZ
cord-332109-ont0tqpn	43	8	been	be	VBN
cord-332109-ont0tqpn	43	9	shown	show	VBN
cord-332109-ont0tqpn	43	10	to	to	TO
cord-332109-ont0tqpn	43	11	have	have	VB
cord-332109-ont0tqpn	43	12	a	a	DT
cord-332109-ont0tqpn	43	13	much	much	RB
cord-332109-ont0tqpn	43	14	higher	high	JJR
cord-332109-ont0tqpn	43	15	binding	bind	VBG
cord-332109-ont0tqpn	43	16	affinity	affinity	NN
cord-332109-ont0tqpn	43	17	to	to	IN
cord-332109-ont0tqpn	43	18	the	the	DT
cord-332109-ont0tqpn	43	19	ACE2	ACE2	NNP
cord-332109-ont0tqpn	43	20	than	than	IN
cord-332109-ont0tqpn	43	21	the	the	DT
cord-332109-ont0tqpn	43	22	SARS	SARS	NNP
cord-332109-ont0tqpn	43	23	-	-	HYPH
cord-332109-ont0tqpn	43	24	CoV	CoV	NNP
cord-332109-ont0tqpn	43	25	S	S	NNP
cord-332109-ont0tqpn	43	26	protein	protein	NN
cord-332109-ont0tqpn	43	27	[	[	-LRB-
cord-332109-ont0tqpn	43	28	23	23	CD
cord-332109-ont0tqpn	43	29	,	,	,
cord-332109-ont0tqpn	43	30	25	25	CD
cord-332109-ont0tqpn	43	31	]	]	-RRB-
cord-332109-ont0tqpn	43	32	.	.	.
cord-332109-ont0tqpn	44	1	The	the	DT
cord-332109-ont0tqpn	44	2	S	S	NNP
cord-332109-ont0tqpn	44	3	protein	protein	NN
cord-332109-ont0tqpn	44	4	contains	contain	VBZ
cord-332109-ont0tqpn	44	5	22	22	CD
cord-332109-ont0tqpn	44	6	N	n	CD
cord-332109-ont0tqpn	44	7	-	-	HYPH
cord-332109-ont0tqpn	44	8	linked	link	VBN
cord-332109-ont0tqpn	44	9	glycans	glycan	NNS
cord-332109-ont0tqpn	44	10	,	,	,
cord-332109-ont0tqpn	44	11	and	and	CC
cord-332109-ont0tqpn	44	12	the	the	DT
cord-332109-ont0tqpn	44	13	complex	complex	JJ
cord-332109-ont0tqpn	44	14	glycosylation	glycosylation	NN
cord-332109-ont0tqpn	44	15	is	be	VBZ
cord-332109-ont0tqpn	44	16	likely	likely	JJ
cord-332109-ont0tqpn	44	17	to	to	TO
cord-332109-ont0tqpn	44	18	play	play	VB
cord-332109-ont0tqpn	44	19	a	a	DT
cord-332109-ont0tqpn	44	20	role	role	NN
cord-332109-ont0tqpn	44	21	in	in	IN
cord-332109-ont0tqpn	44	22	shielding	shielding	NN
cord-332109-ont0tqpn	44	23	and	and	CC
cord-332109-ont0tqpn	44	24	camouflaging	camouflage	VBG
cord-332109-ont0tqpn	44	25	for	for	IN
cord-332109-ont0tqpn	44	26	immune	immune	JJ
cord-332109-ont0tqpn	44	27	evasion	evasion	NN
cord-332109-ont0tqpn	44	28	of	of	IN
cord-332109-ont0tqpn	44	29	the	the	DT
cord-332109-ont0tqpn	44	30	virus	virus	NN
cord-332109-ont0tqpn	44	31	[	[	-LRB-
cord-332109-ont0tqpn	44	32	26	26	CD
cord-332109-ont0tqpn	44	33	,	,	,
cord-332109-ont0tqpn	44	34	27	27	CD
cord-332109-ont0tqpn	44	35	]	]	-RRB-
cord-332109-ont0tqpn	44	36	.	.	.
cord-332109-ont0tqpn	45	1	The	the	DT
cord-332109-ont0tqpn	45	2	S	S	NNP
cord-332109-ont0tqpn	45	3	protein	protein	NN
cord-332109-ont0tqpn	45	4	is	be	VBZ
cord-332109-ont0tqpn	45	5	activated	activate	VBN
cord-332109-ont0tqpn	45	6	by	by	IN
cord-332109-ont0tqpn	45	7	type	type	NN
cord-332109-ont0tqpn	45	8	II	II	NNP
cord-332109-ont0tqpn	45	9	transmembrane	transmembrane	NN
cord-332109-ont0tqpn	45	10	serine	serine	NN
cord-332109-ont0tqpn	45	11	protease	protease	NN
cord-332109-ont0tqpn	45	12	(	(	-LRB-
cord-332109-ont0tqpn	45	13	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	45	14	)	)	-RRB-
cord-332109-ont0tqpn	45	15	,	,	.
cord-332109-ont0tqpn	46	1	a	a	DT
cord-332109-ont0tqpn	46	2	host	host	NN
cord-332109-ont0tqpn	46	3	protease	protease	NN
cord-332109-ont0tqpn	46	4	co	co	NN
cord-332109-ont0tqpn	46	5	-	-	VBD
cord-332109-ont0tqpn	46	6	expressed	express	VBN
cord-332109-ont0tqpn	46	7	with	with	IN
cord-332109-ont0tqpn	46	8	ACE2	ACE2	NNP
cord-332109-ont0tqpn	46	9	on	on	IN
cord-332109-ont0tqpn	46	10	the	the	DT
cord-332109-ont0tqpn	46	11	cell	cell	NN
cord-332109-ont0tqpn	46	12	surface	surface	NN
cord-332109-ont0tqpn	46	13	[	[	-LRB-
cord-332109-ont0tqpn	46	14	24	24	CD
cord-332109-ont0tqpn	46	15	,	,	,
cord-332109-ont0tqpn	46	16	28	28	CD
cord-332109-ont0tqpn	46	17	]	]	-RRB-
cord-332109-ont0tqpn	46	18	.	.	.
cord-332109-ont0tqpn	47	1	In	in	IN
cord-332109-ont0tqpn	47	2	cells	cell	NNS
cord-332109-ont0tqpn	47	3	not	not	RB
cord-332109-ont0tqpn	47	4	expressing	express	VBG
cord-332109-ont0tqpn	47	5	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	47	6	,	,	,
cord-332109-ont0tqpn	47	7	other	other	JJ
cord-332109-ont0tqpn	47	8	proteases	protease	NNS
cord-332109-ont0tqpn	47	9	,	,	,
cord-332109-ont0tqpn	47	10	such	such	JJ
cord-332109-ont0tqpn	47	11	as	as	IN
cord-332109-ont0tqpn	47	12	cathepsin	cathepsin	NN
cord-332109-ont0tqpn	47	13	B	B	NNP
cord-332109-ont0tqpn	47	14	/	/	SYM
cord-332109-ont0tqpn	47	15	L	L	NNP
cord-332109-ont0tqpn	47	16	,	,	,
cord-332109-ont0tqpn	47	17	may	may	MD
cord-332109-ont0tqpn	47	18	activate	activate	VB
cord-332109-ont0tqpn	47	19	the	the	DT
cord-332109-ont0tqpn	47	20	S	S	NNP
cord-332109-ont0tqpn	47	21	protein	protein	NN
cord-332109-ont0tqpn	47	22	and	and	CC
cord-332109-ont0tqpn	47	23	facilitate	facilitate	VB
cord-332109-ont0tqpn	47	24	viral	viral	JJ
cord-332109-ont0tqpn	47	25	entry	entry	NN
cord-332109-ont0tqpn	47	26	[	[	-LRB-
cord-332109-ont0tqpn	47	27	29	29	CD
cord-332109-ont0tqpn	47	28	]	]	-RRB-
cord-332109-ont0tqpn	47	29	.	.	.
cord-332109-ont0tqpn	48	1	Upon	upon	IN
cord-332109-ont0tqpn	48	2	cell	cell	NN
cord-332109-ont0tqpn	48	3	entry	entry	NN
cord-332109-ont0tqpn	48	4	,	,	,
cord-332109-ont0tqpn	48	5	SARS	SARS	NNP
cord-332109-ont0tqpn	48	6	-	-	HYPH
cord-332109-ont0tqpn	48	7	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	48	8	has	have	VBZ
cord-332109-ont0tqpn	48	9	a	a	DT
cord-332109-ont0tqpn	48	10	similar	similar	JJ
cord-332109-ont0tqpn	48	11	life	life	NN
cord-332109-ont0tqpn	48	12	cycle	cycle	NN
cord-332109-ont0tqpn	48	13	and	and	CC
cord-332109-ont0tqpn	48	14	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	48	15	as	as	IN
cord-332109-ont0tqpn	48	16	other	other	JJ
cord-332109-ont0tqpn	48	17	β	β	NN
cord-332109-ont0tqpn	48	18	-	-	HYPH
cord-332109-ont0tqpn	48	19	coronaviruses	coronaviruse	NNS
cord-332109-ont0tqpn	48	20	,	,	,
cord-332109-ont0tqpn	48	21	including	include	VBG
cord-332109-ont0tqpn	48	22	SARS	SARS	NNP
cord-332109-ont0tqpn	48	23	-	-	HYPH
cord-332109-ont0tqpn	48	24	CoV	CoV	NNP
cord-332109-ont0tqpn	48	25	and	and	CC
cord-332109-ont0tqpn	48	26	MERS	MERS	NNP
cord-332109-ont0tqpn	48	27	-	-	HYPH
cord-332109-ont0tqpn	48	28	CoV	CoV	NNP
cord-332109-ont0tqpn	48	29	[	[	-LRB-
cord-332109-ont0tqpn	48	30	30	30	CD
cord-332109-ont0tqpn	48	31	]	]	-RRB-
cord-332109-ont0tqpn	48	32	.	.	.
cord-332109-ont0tqpn	49	1	Upon	upon	IN
cord-332109-ont0tqpn	49	2	ACE2	ACE2	NNP
cord-332109-ont0tqpn	49	3	receptor	receptor	NN
cord-332109-ont0tqpn	49	4	binding	binding	NN
cord-332109-ont0tqpn	49	5	,	,	,
cord-332109-ont0tqpn	49	6	the	the	DT
cord-332109-ont0tqpn	49	7	virus	virus	NN
cord-332109-ont0tqpn	49	8	fuses	fuse	VBZ
cord-332109-ont0tqpn	49	9	its	-PRON-	PRP$
cord-332109-ont0tqpn	49	10	membrane	membrane	NN
cord-332109-ont0tqpn	49	11	with	with	IN
cord-332109-ont0tqpn	49	12	the	the	DT
cord-332109-ont0tqpn	49	13	host	host	NN
cord-332109-ont0tqpn	49	14	cell	cell	NN
cord-332109-ont0tqpn	49	15	plasma	plasma	NN
cord-332109-ont0tqpn	49	16	membrane	membrane	NN
cord-332109-ont0tqpn	49	17	,	,	,
cord-332109-ont0tqpn	49	18	releasing	release	VBG
cord-332109-ont0tqpn	49	19	its	-PRON-	PRP$
cord-332109-ont0tqpn	49	20	genomic	genomic	JJ
cord-332109-ont0tqpn	49	21	RNA	rna	NN
cord-332109-ont0tqpn	49	22	into	into	IN
cord-332109-ont0tqpn	49	23	the	the	DT
cord-332109-ont0tqpn	49	24	cytoplasm	cytoplasm	NN
cord-332109-ont0tqpn	49	25	.	.	.
cord-332109-ont0tqpn	50	1	Since	since	IN
cord-332109-ont0tqpn	50	2	the	the	DT
cord-332109-ont0tqpn	50	3	viral	viral	JJ
cord-332109-ont0tqpn	50	4	RNA	RNA	NNP
cord-332109-ont0tqpn	50	5	is	be	VBZ
cord-332109-ont0tqpn	50	6	similar	similar	JJ
cord-332109-ont0tqpn	50	7	to	to	IN
cord-332109-ont0tqpn	50	8	the	the	DT
cord-332109-ont0tqpn	50	9	human	human	JJ
cord-332109-ont0tqpn	50	10	messenger	messenger	NN
cord-332109-ont0tqpn	50	11	RNA	RNA	NNP
cord-332109-ont0tqpn	50	12	(	(	-LRB-
cord-332109-ont0tqpn	50	13	mRNA	mRNA	NNP
cord-332109-ont0tqpn	50	14	)	)	-RRB-
cord-332109-ont0tqpn	50	15	,	,	,
cord-332109-ont0tqpn	50	16	it	-PRON-	PRP
cord-332109-ont0tqpn	50	17	triggers	trigger	VBZ
cord-332109-ont0tqpn	50	18	the	the	DT
cord-332109-ont0tqpn	50	19	host	host	NN
cord-332109-ont0tqpn	50	20	ribosome	ribosome	NN
cord-332109-ont0tqpn	50	21	to	to	TO
cord-332109-ont0tqpn	50	22	start	start	VB
cord-332109-ont0tqpn	50	23	translating	translate	VBG
cord-332109-ont0tqpn	50	24	the	the	DT
cord-332109-ont0tqpn	50	25	viral	viral	JJ
cord-332109-ont0tqpn	50	26	RNA	RNA	NNP
cord-332109-ont0tqpn	50	27	and	and	CC
cord-332109-ont0tqpn	50	28	producing	produce	VBG
cord-332109-ont0tqpn	50	29	viral	viral	JJ
cord-332109-ont0tqpn	50	30	proteins	protein	NNS
cord-332109-ont0tqpn	50	31	.	.	.
cord-332109-ont0tqpn	51	1	The	the	DT
cord-332109-ont0tqpn	51	2	viral	viral	JJ
cord-332109-ont0tqpn	51	3	replicase	replicase	NN
cord-332109-ont0tqpn	51	4	ORF	ORF	NNP
cord-332109-ont0tqpn	51	5	is	be	VBZ
cord-332109-ont0tqpn	51	6	translated	translate	VBN
cord-332109-ont0tqpn	51	7	into	into	IN
cord-332109-ont0tqpn	51	8	two	two	CD
cord-332109-ont0tqpn	51	9	overlapping	overlap	VBG
cord-332109-ont0tqpn	51	10	polyproteins	polyprotein	NNS
cord-332109-ont0tqpn	51	11	,	,	,
cord-332109-ont0tqpn	51	12	PP1a	PP1a	NNP
cord-332109-ont0tqpn	51	13	(	(	-LRB-
cord-332109-ont0tqpn	51	14	NSP1	NSP1	NNP
cord-332109-ont0tqpn	51	15	-	-	HYPH
cord-332109-ont0tqpn	51	16	11	11	CD
cord-332109-ont0tqpn	51	17	)	)	-RRB-
cord-332109-ont0tqpn	51	18	and	and	CC
cord-332109-ont0tqpn	51	19	PP1ab	PP1ab	NNP
cord-332109-ont0tqpn	51	20	(	(	-LRB-
cord-332109-ont0tqpn	51	21	NSP1	NSP1	NNP
cord-332109-ont0tqpn	51	22	-	-	HYPH
cord-332109-ont0tqpn	51	23	16	16	CD
cord-332109-ont0tqpn	51	24	)	)	-RRB-
cord-332109-ont0tqpn	51	25	,	,	,
cord-332109-ont0tqpn	51	26	which	which	WDT
cord-332109-ont0tqpn	51	27	require	require	VBP
cord-332109-ont0tqpn	51	28	extensive	extensive	JJ
cord-332109-ont0tqpn	51	29	processing	processing	NN
cord-332109-ont0tqpn	51	30	.	.	.
cord-332109-ont0tqpn	52	1	NSP5	NSP5	NNP
cord-332109-ont0tqpn	52	2	,	,	,
cord-332109-ont0tqpn	52	3	the	the	DT
cord-332109-ont0tqpn	52	4	33.8-kDa	33.8-kda	CD
cord-332109-ont0tqpn	52	5	main	main	JJ
cord-332109-ont0tqpn	52	6	viral	viral	JJ
cord-332109-ont0tqpn	52	7	protease	protease	NN
cord-332109-ont0tqpn	52	8	(	(	-LRB-
cord-332109-ont0tqpn	52	9	M	M	NNP
cord-332109-ont0tqpn	52	10	pro	pro	FW
cord-332109-ont0tqpn	52	11	)	)	-RRB-
cord-332109-ont0tqpn	52	12	,	,	,
cord-332109-ont0tqpn	52	13	also	also	RB
cord-332109-ont0tqpn	52	14	referred	refer	VBD
cord-332109-ont0tqpn	52	15	to	to	IN
cord-332109-ont0tqpn	52	16	as	as	IN
cord-332109-ont0tqpn	52	17	the	the	DT
cord-332109-ont0tqpn	52	18	3-chymotrypsin	3-chymotrypsin	CD
cord-332109-ont0tqpn	52	19	-	-	HYPH
cord-332109-ont0tqpn	52	20	like	like	JJ
cord-332109-ont0tqpn	52	21	protease	protease	NN
cord-332109-ont0tqpn	52	22	(	(	-LRB-
cord-332109-ont0tqpn	52	23	3CL	3CL	NNP
cord-332109-ont0tqpn	52	24	pro	pro	JJ
cord-332109-ont0tqpn	52	25	)	)	-RRB-
cord-332109-ont0tqpn	52	26	,	,	,
cord-332109-ont0tqpn	52	27	performs	perform	VBZ
cord-332109-ont0tqpn	52	28	the	the	DT
cord-332109-ont0tqpn	52	29	function	function	NN
cord-332109-ont0tqpn	52	30	by	by	IN
cord-332109-ont0tqpn	52	31	autolytic	autolytic	JJ
cord-332109-ont0tqpn	52	32	cleavage	cleavage	NN
cord-332109-ont0tqpn	52	33	of	of	IN
cord-332109-ont0tqpn	52	34	the	the	DT
cord-332109-ont0tqpn	52	35	protease	protease	NN
cord-332109-ont0tqpn	52	36	itself	-PRON-	PRP
cord-332109-ont0tqpn	52	37	,	,	,
cord-332109-ont0tqpn	52	38	and	and	CC
cord-332109-ont0tqpn	52	39	then	then	RB
cord-332109-ont0tqpn	52	40	subsequently	subsequently	RB
cord-332109-ont0tqpn	52	41	digests	digest	VBZ
cord-332109-ont0tqpn	52	42	the	the	DT
cord-332109-ont0tqpn	52	43	polyproteins	polyprotein	NNS
cord-332109-ont0tqpn	52	44	into	into	IN
cord-332109-ont0tqpn	52	45	16	16	CD
cord-332109-ont0tqpn	52	46	non	non	JJ
cord-332109-ont0tqpn	52	47	-	-	JJ
cord-332109-ont0tqpn	52	48	structural	structural	JJ
cord-332109-ont0tqpn	52	49	proteins	protein	NNS
cord-332109-ont0tqpn	52	50	.	.	.
cord-332109-ont0tqpn	53	1	NSP12	NSP12	NNP
cord-332109-ont0tqpn	53	2	,	,	,
cord-332109-ont0tqpn	53	3	known	know	VBN
cord-332109-ont0tqpn	53	4	as	as	IN
cord-332109-ont0tqpn	53	5	the	the	DT
cord-332109-ont0tqpn	53	6	RNA	RNA	NNP
cord-332109-ont0tqpn	53	7	-	-	HYPH
cord-332109-ont0tqpn	53	8	dependent	dependent	JJ
cord-332109-ont0tqpn	53	9	RNA	RNA	NNP
cord-332109-ont0tqpn	53	10	polymerase	polymerase	NN
cord-332109-ont0tqpn	53	11	(	(	-LRB-
cord-332109-ont0tqpn	53	12	RdRp	RdRp	NNP
cord-332109-ont0tqpn	53	13	)	)	-RRB-
cord-332109-ont0tqpn	53	14	,	,	,
cord-332109-ont0tqpn	53	15	together	together	RB
cord-332109-ont0tqpn	53	16	with	with	IN
cord-332109-ont0tqpn	53	17	NSP7	NSP7	NNP
cord-332109-ont0tqpn	53	18	and	and	CC
cord-332109-ont0tqpn	53	19	NSP8	NSP8	NNP
cord-332109-ont0tqpn	53	20	,	,	,
cord-332109-ont0tqpn	53	21	carries	carry	VBZ
cord-332109-ont0tqpn	53	22	out	out	RP
cord-332109-ont0tqpn	53	23	the	the	DT
cord-332109-ont0tqpn	53	24	critical	critical	JJ
cord-332109-ont0tqpn	53	25	process	process	NN
cord-332109-ont0tqpn	53	26	of	of	IN
cord-332109-ont0tqpn	53	27	the	the	DT
cord-332109-ont0tqpn	53	28	viral	viral	JJ
cord-332109-ont0tqpn	53	29	RNA	RNA	NNP
cord-332109-ont0tqpn	53	30	synthesis	synthesis	NN
cord-332109-ont0tqpn	53	31	,	,	,
cord-332109-ont0tqpn	53	32	and	and	CC
cord-332109-ont0tqpn	53	33	is	be	VBZ
cord-332109-ont0tqpn	53	34	central	central	JJ
cord-332109-ont0tqpn	53	35	to	to	IN
cord-332109-ont0tqpn	53	36	the	the	DT
cord-332109-ont0tqpn	53	37	viral	viral	JJ
cord-332109-ont0tqpn	53	38	replication	replication	NN
cord-332109-ont0tqpn	53	39	and	and	CC
cord-332109-ont0tqpn	53	40	transcription	transcription	NN
cord-332109-ont0tqpn	53	41	cycle	cycle	NN
cord-332109-ont0tqpn	53	42	.	.	.
cord-332109-ont0tqpn	54	1	The	the	DT
cord-332109-ont0tqpn	54	2	N	n	CD
cord-332109-ont0tqpn	54	3	-	-	HYPH
cord-332109-ont0tqpn	54	4	terminal	terminal	NN
cord-332109-ont0tqpn	54	5	non	non	JJ
cord-332109-ont0tqpn	54	6	-	-	JJ
cord-332109-ont0tqpn	54	7	structural	structural	JJ
cord-332109-ont0tqpn	54	8	protein	protein	NN
cord-332109-ont0tqpn	54	9	,	,	,
cord-332109-ont0tqpn	54	10	NSP1	NSP1	NNP
cord-332109-ont0tqpn	54	11	,	,	,
cord-332109-ont0tqpn	54	12	has	have	VBZ
cord-332109-ont0tqpn	54	13	been	be	VBN
cord-332109-ont0tqpn	54	14	shown	show	VBN
cord-332109-ont0tqpn	54	15	to	to	TO
cord-332109-ont0tqpn	54	16	bind	bind	VB
cord-332109-ont0tqpn	54	17	to	to	IN
cord-332109-ont0tqpn	54	18	the	the	DT
cord-332109-ont0tqpn	54	19	40S	40s	CD
cord-332109-ont0tqpn	54	20	small	small	JJ
cord-332109-ont0tqpn	54	21	ribosomal	ribosomal	JJ
cord-332109-ont0tqpn	54	22	subunit	subunit	NN
cord-332109-ont0tqpn	54	23	,	,	,
cord-332109-ont0tqpn	54	24	shutting	shut	VBG
cord-332109-ont0tqpn	54	25	down	down	RP
cord-332109-ont0tqpn	54	26	all	all	DT
cord-332109-ont0tqpn	54	27	host	host	NN
cord-332109-ont0tqpn	54	28	cell	cell	NN
cord-332109-ont0tqpn	54	29	protein	protein	NN
cord-332109-ont0tqpn	54	30	production	production	NN
cord-332109-ont0tqpn	54	31	by	by	IN
cord-332109-ont0tqpn	54	32	blocking	block	VBG
cord-332109-ont0tqpn	54	33	the	the	DT
cord-332109-ont0tqpn	54	34	mRNA	mRNA	NNP
cord-332109-ont0tqpn	54	35	entry	entry	NN
cord-332109-ont0tqpn	54	36	tunnel	tunnel	NN
cord-332109-ont0tqpn	54	37	.	.	.
cord-332109-ont0tqpn	55	1	NSP1	nsp1	NN
cord-332109-ont0tqpn	55	2	binding	bind	VBG
cord-332109-ont0tqpn	55	3	to	to	IN
cord-332109-ont0tqpn	55	4	ribosomes	ribosome	NNS
cord-332109-ont0tqpn	55	5	and	and	CC
cord-332109-ont0tqpn	55	6	blocking	block	VBG
cord-332109-ont0tqpn	55	7	host	host	NN
cord-332109-ont0tqpn	55	8	cell	cell	NN
cord-332109-ont0tqpn	55	9	translation	translation	NN
cord-332109-ont0tqpn	55	10	effectively	effectively	RB
cord-332109-ont0tqpn	55	11	inhibits	inhibit	VBZ
cord-332109-ont0tqpn	55	12	type	type	NN
cord-332109-ont0tqpn	55	13	-	-	:
cord-332109-ont0tqpn	55	14	I	i	NN
cord-332109-ont0tqpn	56	1	interferon	interferon	NNP
cord-332109-ont0tqpn	56	2	(	(	-LRB-
cord-332109-ont0tqpn	56	3	IFN	IFN	NNP
cord-332109-ont0tqpn	56	4	-	-	HYPH
cord-332109-ont0tqpn	56	5	I)-induced	I)-induced	NNP
cord-332109-ont0tqpn	56	6	innate	innate	JJ
cord-332109-ont0tqpn	56	7	immune	immune	JJ
cord-332109-ont0tqpn	56	8	response	response	NN
cord-332109-ont0tqpn	56	9	by	by	IN
cord-332109-ont0tqpn	56	10	turning	turn	VBG
cord-332109-ont0tqpn	56	11	off	off	RP
cord-332109-ont0tqpn	56	12	the	the	DT
cord-332109-ont0tqpn	56	13	retinoic	retinoic	JJ
cord-332109-ont0tqpn	56	14	acid	acid	NN
cord-332109-ont0tqpn	56	15	-	-	HYPH
cord-332109-ont0tqpn	56	16	inducible	inducible	JJ
cord-332109-ont0tqpn	56	17	gene	gene	NN
cord-332109-ont0tqpn	56	18	(	(	-LRB-
cord-332109-ont0tqpn	56	19	RIG)-I	RIG)-I	NNP
cord-332109-ont0tqpn	56	20	antiviral	antiviral	JJ
cord-332109-ont0tqpn	56	21	sensor	sensor	NN
cord-332109-ont0tqpn	56	22	[	[	-LRB-
cord-332109-ont0tqpn	56	23	31	31	CD
cord-332109-ont0tqpn	56	24	]	]	-RRB-
cord-332109-ont0tqpn	56	25	.	.	.
cord-332109-ont0tqpn	57	1	The	the	DT
cord-332109-ont0tqpn	57	2	inhibition	inhibition	NN
cord-332109-ont0tqpn	57	3	of	of	IN
cord-332109-ont0tqpn	57	4	the	the	DT
cord-332109-ont0tqpn	57	5	IFN	IFN	NNP
cord-332109-ont0tqpn	57	6	-	-	HYPH
cord-332109-ont0tqpn	57	7	I	I	NNP
cord-332109-ont0tqpn	57	8	-	-	HYPH
cord-332109-ont0tqpn	57	9	induced	induce	VBN
cord-332109-ont0tqpn	57	10	innate	innate	JJ
cord-332109-ont0tqpn	57	11	immunity	immunity	NN
cord-332109-ont0tqpn	57	12	allows	allow	VBZ
cord-332109-ont0tqpn	57	13	the	the	DT
cord-332109-ont0tqpn	57	14	assembly	assembly	NN
cord-332109-ont0tqpn	57	15	of	of	IN
cord-332109-ont0tqpn	57	16	viral	viral	JJ
cord-332109-ont0tqpn	57	17	particles	particle	NNS
cord-332109-ont0tqpn	57	18	inside	inside	IN
cord-332109-ont0tqpn	57	19	the	the	DT
cord-332109-ont0tqpn	57	20	host	host	NN
cord-332109-ont0tqpn	57	21	cell	cell	NN
cord-332109-ont0tqpn	57	22	.	.	.
cord-332109-ont0tqpn	58	1	The	the	DT
cord-332109-ont0tqpn	58	2	newly	newly	RB
cord-332109-ont0tqpn	58	3	produced	produce	VBN
cord-332109-ont0tqpn	58	4	structural	structural	JJ
cord-332109-ont0tqpn	58	5	proteins	protein	NNS
cord-332109-ont0tqpn	58	6	,	,	,
cord-332109-ont0tqpn	58	7	S	S	NNP
cord-332109-ont0tqpn	58	8	,	,	,
cord-332109-ont0tqpn	58	9	M	M	NNP
cord-332109-ont0tqpn	58	10	,	,	,
cord-332109-ont0tqpn	58	11	and	and	CC
cord-332109-ont0tqpn	58	12	E	E	NNP
cord-332109-ont0tqpn	58	13	,	,	,
cord-332109-ont0tqpn	58	14	are	be	VBP
cord-332109-ont0tqpn	58	15	inserted	insert	VBN
cord-332109-ont0tqpn	58	16	into	into	IN
cord-332109-ont0tqpn	58	17	the	the	DT
cord-332109-ont0tqpn	58	18	endoplasmic	endoplasmic	NN
cord-332109-ont0tqpn	58	19	reticulum	reticulum	NN
cord-332109-ont0tqpn	58	20	(	(	-LRB-
cord-332109-ont0tqpn	58	21	ER	ER	NNP
cord-332109-ont0tqpn	58	22	)	)	-RRB-
cord-332109-ont0tqpn	58	23	or	or	CC
cord-332109-ont0tqpn	58	24	Golgi	Golgi	NNP
cord-332109-ont0tqpn	58	25	membrane	membrane	NN
cord-332109-ont0tqpn	58	26	,	,	,
cord-332109-ont0tqpn	58	27	while	while	IN
cord-332109-ont0tqpn	58	28	the	the	DT
cord-332109-ont0tqpn	58	29	N	N	NNP
cord-332109-ont0tqpn	58	30	protein	protein	NN
cord-332109-ont0tqpn	58	31	associates	associate	NNS
cord-332109-ont0tqpn	58	32	with	with	IN
cord-332109-ont0tqpn	58	33	the	the	DT
cord-332109-ont0tqpn	58	34	newly	newly	RB
cord-332109-ont0tqpn	58	35	synthesized	synthesize	VBN
cord-332109-ont0tqpn	58	36	viral	viral	JJ
cord-332109-ont0tqpn	58	37	RNA	RNA	NNP
cord-332109-ont0tqpn	58	38	to	to	TO
cord-332109-ont0tqpn	58	39	stabilize	stabilize	VB
cord-332109-ont0tqpn	58	40	the	the	DT
cord-332109-ont0tqpn	58	41	genome	genome	NN
cord-332109-ont0tqpn	58	42	.	.	.
cord-332109-ont0tqpn	59	1	The	the	DT
cord-332109-ont0tqpn	59	2	viral	viral	JJ
cord-332109-ont0tqpn	59	3	particles	particle	NNS
cord-332109-ont0tqpn	59	4	are	be	VBP
cord-332109-ont0tqpn	59	5	assembled	assemble	VBN
cord-332109-ont0tqpn	59	6	into	into	IN
cord-332109-ont0tqpn	59	7	the	the	DT
cord-332109-ont0tqpn	59	8	ER	ER	NNP
cord-332109-ont0tqpn	59	9	-	-	HYPH
cord-332109-ont0tqpn	59	10	Golgi	Golgi	NNP
cord-332109-ont0tqpn	59	11	intermediate	intermediate	JJ
cord-332109-ont0tqpn	59	12	compartment	compartment	NN
cord-332109-ont0tqpn	59	13	(	(	-LRB-
cord-332109-ont0tqpn	59	14	ERGIC	ERGIC	NNP
cord-332109-ont0tqpn	59	15	)	)	-RRB-
cord-332109-ont0tqpn	59	16	,	,	,
cord-332109-ont0tqpn	59	17	fuse	fuse	VB
cord-332109-ont0tqpn	59	18	with	with	IN
cord-332109-ont0tqpn	59	19	the	the	DT
cord-332109-ont0tqpn	59	20	plasma	plasma	NN
cord-332109-ont0tqpn	59	21	membrane	membrane	NN
cord-332109-ont0tqpn	59	22	,	,	,
cord-332109-ont0tqpn	59	23	and	and	CC
cord-332109-ont0tqpn	59	24	bud	bud	NN
cord-332109-ont0tqpn	59	25	off	off	RP
cord-332109-ont0tqpn	59	26	the	the	DT
cord-332109-ont0tqpn	59	27	host	host	NN
cord-332109-ont0tqpn	59	28	cell	cell	NN
cord-332109-ont0tqpn	59	29	.	.	.
cord-332109-ont0tqpn	60	1	The	the	DT
cord-332109-ont0tqpn	60	2	released	release	VBN
cord-332109-ont0tqpn	60	3	virions	virion	NNS
cord-332109-ont0tqpn	60	4	will	will	MD
cord-332109-ont0tqpn	60	5	further	further	RB
cord-332109-ont0tqpn	60	6	infect	infect	VB
cord-332109-ont0tqpn	60	7	more	more	JJR
cord-332109-ont0tqpn	60	8	cells	cell	NNS
cord-332109-ont0tqpn	60	9	.	.	.
cord-332109-ont0tqpn	61	1	The	the	DT
cord-332109-ont0tqpn	61	2	functions	function	NNS
cord-332109-ont0tqpn	61	3	of	of	IN
cord-332109-ont0tqpn	61	4	other	other	JJ
cord-332109-ont0tqpn	61	5	NSPs	nsp	NNS
cord-332109-ont0tqpn	61	6	are	be	VBP
cord-332109-ont0tqpn	61	7	not	not	RB
cord-332109-ont0tqpn	61	8	fully	fully	RB
cord-332109-ont0tqpn	61	9	understood	understand	VBN
cord-332109-ont0tqpn	61	10	.	.	.
cord-332109-ont0tqpn	62	1	A	a	DT
cord-332109-ont0tqpn	62	2	comparative	comparative	JJ
cord-332109-ont0tqpn	62	3	structural	structural	JJ
cord-332109-ont0tqpn	62	4	genomics	genomic	NNS
cord-332109-ont0tqpn	62	5	study	study	NN
cord-332109-ont0tqpn	62	6	revealed	reveal	VBD
cord-332109-ont0tqpn	62	7	a	a	DT
cord-332109-ont0tqpn	62	8	possible	possible	JJ
cord-332109-ont0tqpn	62	9	functional	functional	JJ
cord-332109-ont0tqpn	62	10	intra	intra	JJ
cord-332109-ont0tqpn	62	11	-	-	JJ
cord-332109-ont0tqpn	62	12	viral	viral	JJ
cord-332109-ont0tqpn	62	13	and	and	CC
cord-332109-ont0tqpn	62	14	human	human	JJ
cord-332109-ont0tqpn	62	15	-	-	HYPH
cord-332109-ont0tqpn	62	16	virus	virus	NN
cord-332109-ont0tqpn	62	17	interaction	interaction	NN
cord-332109-ont0tqpn	62	18	network	network	NN
cord-332109-ont0tqpn	62	19	of	of	IN
cord-332109-ont0tqpn	62	20	NSPs	nsp	NNS
cord-332109-ont0tqpn	62	21	[	[	-LRB-
cord-332109-ont0tqpn	62	22	32	32	CD
cord-332109-ont0tqpn	62	23	]	]	-RRB-
cord-332109-ont0tqpn	62	24	.	.	.
cord-332109-ont0tqpn	63	1	Recurrent	recurrent	JJ
cord-332109-ont0tqpn	63	2	mutations	mutation	NNS
cord-332109-ont0tqpn	63	3	in	in	IN
cord-332109-ont0tqpn	63	4	the	the	DT
cord-332109-ont0tqpn	63	5	SARS	SARS	NNP
cord-332109-ont0tqpn	63	6	-	-	HYPH
cord-332109-ont0tqpn	63	7	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	63	8	genome	genome	NN
cord-332109-ont0tqpn	63	9	have	have	VBP
cord-332109-ont0tqpn	63	10	been	be	VBN
cord-332109-ont0tqpn	63	11	identified	identify	VBN
cord-332109-ont0tqpn	63	12	in	in	IN
cord-332109-ont0tqpn	63	13	some	some	DT
cord-332109-ont0tqpn	63	14	NSPs	nsp	NNS
cord-332109-ont0tqpn	63	15	and	and	CC
cord-332109-ont0tqpn	63	16	the	the	DT
cord-332109-ont0tqpn	63	17	S	S	NNP
cord-332109-ont0tqpn	63	18	protein	protein	NN
cord-332109-ont0tqpn	63	19	,	,	,
cord-332109-ont0tqpn	63	20	suggesting	suggest	VBG
cord-332109-ont0tqpn	63	21	ongoing	ongoing	JJ
cord-332109-ont0tqpn	63	22	adaptations	adaptation	NNS
cord-332109-ont0tqpn	63	23	of	of	IN
cord-332109-ont0tqpn	63	24	the	the	DT
cord-332109-ont0tqpn	63	25	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	63	26	through	through	IN
cord-332109-ont0tqpn	63	27	transmission	transmission	NN
cord-332109-ont0tqpn	63	28	[	[	-LRB-
cord-332109-ont0tqpn	63	29	33	33	CD
cord-332109-ont0tqpn	63	30	]	]	-RRB-
cord-332109-ont0tqpn	63	31	.	.	.
cord-332109-ont0tqpn	64	1	Particularly	particularly	RB
cord-332109-ont0tqpn	64	2	,	,	,
cord-332109-ont0tqpn	64	3	the	the	DT
cord-332109-ont0tqpn	64	4	D614	d614	NN
cord-332109-ont0tqpn	64	5	G	g	NN
cord-332109-ont0tqpn	64	6	mutation	mutation	NN
cord-332109-ont0tqpn	64	7	in	in	IN
cord-332109-ont0tqpn	64	8	the	the	DT
cord-332109-ont0tqpn	64	9	S	S	NNP
cord-332109-ont0tqpn	64	10	protein	protein	NN
cord-332109-ont0tqpn	64	11	makes	make	VBZ
cord-332109-ont0tqpn	64	12	it	-PRON-	PRP
cord-332109-ont0tqpn	64	13	more	more	RBR
cord-332109-ont0tqpn	64	14	stable	stable	JJ
cord-332109-ont0tqpn	64	15	,	,	,
cord-332109-ont0tqpn	64	16	and	and	CC
cord-332109-ont0tqpn	64	17	the	the	DT
cord-332109-ont0tqpn	64	18	virus	virus	NN
cord-332109-ont0tqpn	64	19	becomes	become	VBZ
cord-332109-ont0tqpn	64	20	more	more	RBR
cord-332109-ont0tqpn	64	21	infectious	infectious	JJ
cord-332109-ont0tqpn	64	22	and	and	CC
cord-332109-ont0tqpn	64	23	transmissible	transmissible	JJ
cord-332109-ont0tqpn	64	24	[	[	-LRB-
cord-332109-ont0tqpn	64	25	34	34	CD
cord-332109-ont0tqpn	64	26	,	,	,
cord-332109-ont0tqpn	64	27	35	35	CD
cord-332109-ont0tqpn	64	28	]	]	-RRB-
cord-332109-ont0tqpn	64	29	.	.	.
cord-332109-ont0tqpn	65	1	This	this	DT
cord-332109-ont0tqpn	65	2	mutated	mutate	VBN
cord-332109-ont0tqpn	65	3	virus	virus	NN
cord-332109-ont0tqpn	65	4	is	be	VBZ
cord-332109-ont0tqpn	65	5	the	the	DT
cord-332109-ont0tqpn	65	6	dominant	dominant	JJ
cord-332109-ont0tqpn	65	7	form	form	NN
cord-332109-ont0tqpn	65	8	in	in	IN
cord-332109-ont0tqpn	65	9	Europe	Europe	NNP
cord-332109-ont0tqpn	65	10	and	and	CC
cord-332109-ont0tqpn	65	11	North	North	NNP
cord-332109-ont0tqpn	65	12	America	America	NNP
cord-332109-ont0tqpn	65	13	since	since	IN
cord-332109-ont0tqpn	65	14	March	March	NNP
cord-332109-ont0tqpn	65	15	2020	2020	CD
cord-332109-ont0tqpn	65	16	[	[	-LRB-
cord-332109-ont0tqpn	65	17	36	36	CD
cord-332109-ont0tqpn	65	18	]	]	-RRB-
cord-332109-ont0tqpn	65	19	.	.	.
cord-332109-ont0tqpn	66	1	Underlying	underlie	VBG
cord-332109-ont0tqpn	66	2	medical	medical	JJ
cord-332109-ont0tqpn	66	3	conditions	condition	NNS
cord-332109-ont0tqpn	66	4	can	can	MD
cord-332109-ont0tqpn	66	5	put	put	VB
cord-332109-ont0tqpn	66	6	individuals	individual	NNS
cord-332109-ont0tqpn	66	7	at	at	IN
cord-332109-ont0tqpn	66	8	increased	increase	VBN
cord-332109-ont0tqpn	66	9	risk	risk	NN
cord-332109-ont0tqpn	66	10	for	for	IN
cord-332109-ont0tqpn	66	11	severe	severe	JJ
cord-332109-ont0tqpn	66	12	illness	illness	NN
cord-332109-ont0tqpn	66	13	from	from	IN
cord-332109-ont0tqpn	66	14	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	66	15	.	.	.
cord-332109-ont0tqpn	67	1	The	the	DT
cord-332109-ont0tqpn	67	2	comorbid	comorbid	NN
cord-332109-ont0tqpn	67	3	conditions	condition	NNS
cord-332109-ont0tqpn	67	4	include	include	VBP
cord-332109-ont0tqpn	67	5	COPD	COPD	NNP
cord-332109-ont0tqpn	67	6	,	,	,
cord-332109-ont0tqpn	67	7	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	67	8	diseases	disease	NNS
cord-332109-ont0tqpn	67	9	,	,	,
cord-332109-ont0tqpn	67	10	other	other	JJ
cord-332109-ont0tqpn	67	11	chronical	chronical	JJ
cord-332109-ont0tqpn	67	12	respiratory	respiratory	JJ
cord-332109-ont0tqpn	67	13	diseases	disease	NNS
cord-332109-ont0tqpn	67	14	,	,	,
cord-332109-ont0tqpn	67	15	diabetes	diabetes	NN
cord-332109-ont0tqpn	67	16	,	,	,
cord-332109-ont0tqpn	67	17	obesity	obesity	NN
cord-332109-ont0tqpn	67	18	,	,	,
cord-332109-ont0tqpn	67	19	and	and	CC
cord-332109-ont0tqpn	67	20	cancer	cancer	NN
cord-332109-ont0tqpn	67	21	.	.	.
cord-332109-ont0tqpn	68	1	According	accord	VBG
cord-332109-ont0tqpn	68	2	to	to	IN
cord-332109-ont0tqpn	68	3	a	a	DT
cord-332109-ont0tqpn	68	4	large	large	JJ
cord-332109-ont0tqpn	68	5	-	-	HYPH
cord-332109-ont0tqpn	68	6	scale	scale	NN
cord-332109-ont0tqpn	68	7	study	study	NN
cord-332109-ont0tqpn	68	8	with	with	IN
cord-332109-ont0tqpn	68	9	72,314	72,314	CD
cord-332109-ont0tqpn	68	10	cases	case	NNS
cord-332109-ont0tqpn	68	11	conducted	conduct	VBN
cord-332109-ont0tqpn	68	12	by	by	IN
cord-332109-ont0tqpn	68	13	the	the	DT
cord-332109-ont0tqpn	68	14	Chinese	chinese	JJ
cord-332109-ont0tqpn	68	15	CDC	CDC	NNP
cord-332109-ont0tqpn	68	16	,	,	,
cord-332109-ont0tqpn	68	17	case	case	NN
cord-332109-ont0tqpn	68	18	-	-	HYPH
cord-332109-ont0tqpn	68	19	fatality	fatality	NN
cord-332109-ont0tqpn	68	20	and	and	CC
cord-332109-ont0tqpn	68	21	mortality	mortality	NN
cord-332109-ont0tqpn	68	22	rates	rate	NNS
cord-332109-ont0tqpn	68	23	are	be	VBP
cord-332109-ont0tqpn	68	24	significantly	significantly	RB
cord-332109-ont0tqpn	68	25	increased	increase	VBN
cord-332109-ont0tqpn	68	26	in	in	IN
cord-332109-ont0tqpn	68	27	patients	patient	NNS
cord-332109-ont0tqpn	68	28	with	with	IN
cord-332109-ont0tqpn	68	29	comorbid	comorbid	NN
cord-332109-ont0tqpn	68	30	conditions	condition	NNS
cord-332109-ont0tqpn	68	31	comparing	compare	VBG
cord-332109-ont0tqpn	68	32	to	to	IN
cord-332109-ont0tqpn	68	33	those	those	DT
cord-332109-ont0tqpn	68	34	with	with	IN
cord-332109-ont0tqpn	68	35	no	no	DT
cord-332109-ont0tqpn	68	36	underlying	underlie	VBG
cord-332109-ont0tqpn	68	37	conditions	condition	NNS
cord-332109-ont0tqpn	68	38	(	(	-LRB-
cord-332109-ont0tqpn	68	39	Table	table	NN
cord-332109-ont0tqpn	68	40	1	1	CD
cord-332109-ont0tqpn	68	41	)	)	-RRB-
cord-332109-ont0tqpn	68	42	[	[	-LRB-
cord-332109-ont0tqpn	68	43	12	12	CD
cord-332109-ont0tqpn	68	44	]	]	-RRB-
cord-332109-ont0tqpn	68	45	.	.	.
cord-332109-ont0tqpn	69	1	In	in	IN
cord-332109-ont0tqpn	69	2	a	a	DT
cord-332109-ont0tqpn	69	3	study	study	NN
cord-332109-ont0tqpn	69	4	in	in	IN
cord-332109-ont0tqpn	69	5	New	New	NNP
cord-332109-ont0tqpn	69	6	York	York	NNP
cord-332109-ont0tqpn	69	7	City	City	NNP
cord-332109-ont0tqpn	69	8	,	,	,
cord-332109-ont0tqpn	69	9	the	the	DT
cord-332109-ont0tqpn	69	10	epicenter	epicenter	NN
cord-332109-ont0tqpn	69	11	of	of	IN
cord-332109-ont0tqpn	69	12	the	the	DT
cord-332109-ont0tqpn	69	13	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	69	14	pandemic	pandemic	NN
cord-332109-ont0tqpn	69	15	in	in	IN
cord-332109-ont0tqpn	69	16	the	the	DT
cord-332109-ont0tqpn	69	17	U.S.	U.S.	NNP
cord-332109-ont0tqpn	69	18	,	,	,
cord-332109-ont0tqpn	69	19	comorbid	comorbid	NN
cord-332109-ont0tqpn	69	20	conditions	condition	NNS
cord-332109-ont0tqpn	69	21	are	be	VBP
cord-332109-ont0tqpn	69	22	highly	highly	RB
cord-332109-ont0tqpn	69	23	associated	associate	VBN
cord-332109-ont0tqpn	69	24	with	with	IN
cord-332109-ont0tqpn	69	25	hospitalization	hospitalization	NN
cord-332109-ont0tqpn	69	26	and	and	CC
cord-332109-ont0tqpn	69	27	severity	severity	NN
cord-332109-ont0tqpn	69	28	of	of	IN
cord-332109-ont0tqpn	69	29	the	the	DT
cord-332109-ont0tqpn	69	30	illness	illness	NN
cord-332109-ont0tqpn	69	31	(	(	-LRB-
cord-332109-ont0tqpn	69	32	Table	table	NN
cord-332109-ont0tqpn	69	33	2	2	CD
cord-332109-ont0tqpn	69	34	)	)	-RRB-
cord-332109-ont0tqpn	69	35	[	[	-LRB-
cord-332109-ont0tqpn	69	36	37	37	CD
cord-332109-ont0tqpn	69	37	]	]	-RRB-
cord-332109-ont0tqpn	69	38	.	.	.
cord-332109-ont0tqpn	70	1	A	a	DT
cord-332109-ont0tqpn	70	2	nationwide	nationwide	JJ
cord-332109-ont0tqpn	70	3	case	case	NN
cord-332109-ont0tqpn	70	4	-	-	HYPH
cord-332109-ont0tqpn	70	5	control	control	NN
cord-332109-ont0tqpn	70	6	study	study	NN
cord-332109-ont0tqpn	70	7	in	in	IN
cord-332109-ont0tqpn	70	8	Korea	Korea	NNP
cord-332109-ont0tqpn	70	9	also	also	RB
cord-332109-ont0tqpn	70	10	confirmed	confirm	VBD
cord-332109-ont0tqpn	70	11	that	that	IN
cord-332109-ont0tqpn	70	12	diabetes	diabetes	NN
cord-332109-ont0tqpn	70	13	,	,	,
cord-332109-ont0tqpn	70	14	hypertension	hypertension	NN
cord-332109-ont0tqpn	70	15	,	,	,
cord-332109-ont0tqpn	70	16	and	and	CC
cord-332109-ont0tqpn	70	17	chronic	chronic	JJ
cord-332109-ont0tqpn	70	18	respiratory	respiratory	JJ
cord-332109-ont0tqpn	70	19	disease	disease	NN
cord-332109-ont0tqpn	70	20	,	,	,
cord-332109-ont0tqpn	70	21	among	among	IN
cord-332109-ont0tqpn	70	22	others	other	NNS
cord-332109-ont0tqpn	70	23	,	,	,
cord-332109-ont0tqpn	70	24	were	be	VBD
cord-332109-ont0tqpn	70	25	associated	associate	VBN
cord-332109-ont0tqpn	70	26	with	with	IN
cord-332109-ont0tqpn	70	27	severe	severe	JJ
cord-332109-ont0tqpn	70	28	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	70	29	[	[	-LRB-
cord-332109-ont0tqpn	70	30	38	38	CD
cord-332109-ont0tqpn	70	31	]	]	-RRB-
cord-332109-ont0tqpn	70	32	.	.	.
cord-332109-ont0tqpn	71	1	Individuals	individual	NNS
cord-332109-ont0tqpn	71	2	with	with	IN
cord-332109-ont0tqpn	71	3	SUDs	sud	NNS
cord-332109-ont0tqpn	71	4	commonly	commonly	RB
cord-332109-ont0tqpn	71	5	experience	experience	VBP
cord-332109-ont0tqpn	71	6	respiratory	respiratory	JJ
cord-332109-ont0tqpn	71	7	and	and	CC
cord-332109-ont0tqpn	71	8	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	71	9	disorders	disorder	NNS
cord-332109-ont0tqpn	71	10	,	,	,
cord-332109-ont0tqpn	71	11	including	include	VBG
cord-332109-ont0tqpn	71	12	hypertension	hypertension	NN
cord-332109-ont0tqpn	71	13	and	and	CC
cord-332109-ont0tqpn	71	14	COPD	COPD	NNP
cord-332109-ont0tqpn	71	15	,	,	,
cord-332109-ont0tqpn	71	16	and	and	CC
cord-332109-ont0tqpn	71	17	have	have	VBP
cord-332109-ont0tqpn	71	18	undermined	undermine	VBN
cord-332109-ont0tqpn	71	19	immune	immune	JJ
cord-332109-ont0tqpn	71	20	systems	system	NNS
cord-332109-ont0tqpn	71	21	,	,	,
cord-332109-ont0tqpn	71	22	making	make	VBG
cord-332109-ont0tqpn	71	23	them	-PRON-	PRP
cord-332109-ont0tqpn	71	24	particularly	particularly	RB
cord-332109-ont0tqpn	71	25	vulnerable	vulnerable	JJ
cord-332109-ont0tqpn	71	26	in	in	IN
cord-332109-ont0tqpn	71	27	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	71	28	.	.	.
cord-332109-ont0tqpn	72	1	A	a	DT
cord-332109-ont0tqpn	72	2	significant	significant	JJ
cord-332109-ont0tqpn	72	3	portion	portion	NN
cord-332109-ont0tqpn	72	4	of	of	IN
cord-332109-ont0tqpn	72	5	individuals	individual	NNS
cord-332109-ont0tqpn	72	6	with	with	IN
cord-332109-ont0tqpn	72	7	SUDs	sud	NNS
cord-332109-ont0tqpn	72	8	have	have	VBP
cord-332109-ont0tqpn	72	9	underlying	underlying	JJ
cord-332109-ont0tqpn	72	10	medical	medical	JJ
cord-332109-ont0tqpn	72	11	conditions	condition	NNS
cord-332109-ont0tqpn	72	12	,	,	,
cord-332109-ont0tqpn	72	13	and	and	CC
cord-332109-ont0tqpn	72	14	are	be	VBP
cord-332109-ont0tqpn	72	15	more	more	RBR
cord-332109-ont0tqpn	72	16	likely	likely	JJ
cord-332109-ont0tqpn	72	17	to	to	TO
cord-332109-ont0tqpn	72	18	be	be	VB
cord-332109-ont0tqpn	72	19	marginalized	marginalize	VBN
cord-332109-ont0tqpn	72	20	.	.	.
cord-332109-ont0tqpn	73	1	According	accord	VBG
cord-332109-ont0tqpn	73	2	to	to	IN
cord-332109-ont0tqpn	73	3	a	a	DT
cord-332109-ont0tqpn	73	4	recent	recent	JJ
cord-332109-ont0tqpn	73	5	study	study	NN
cord-332109-ont0tqpn	73	6	in	in	IN
cord-332109-ont0tqpn	73	7	British	British	NNP
cord-332109-ont0tqpn	73	8	Columbia	Columbia	NNP
cord-332109-ont0tqpn	73	9	,	,	,
cord-332109-ont0tqpn	73	10	Canada	Canada	NNP
cord-332109-ont0tqpn	73	11	,	,	,
cord-332109-ont0tqpn	73	12	among	among	IN
cord-332109-ont0tqpn	73	13	19,005	19,005	CD
cord-332109-ont0tqpn	73	14	individuals	individual	NNS
cord-332109-ont0tqpn	73	15	who	who	WP
cord-332109-ont0tqpn	73	16	had	have	VBD
cord-332109-ont0tqpn	73	17	one	one	CD
cord-332109-ont0tqpn	73	18	or	or	CC
cord-332109-ont0tqpn	73	19	more	more	JJR
cord-332109-ont0tqpn	73	20	non	non	JJ
cord-332109-ont0tqpn	73	21	-	-	JJ
cord-332109-ont0tqpn	73	22	fatal	fatal	JJ
cord-332109-ont0tqpn	73	23	overdose	overdose	NN
cord-332109-ont0tqpn	73	24	events	event	NNS
cord-332109-ont0tqpn	73	25	between	between	IN
cord-332109-ont0tqpn	73	26	2015	2015	CD
cord-332109-ont0tqpn	73	27	and	and	CC
cord-332109-ont0tqpn	73	28	2017	2017	CD
cord-332109-ont0tqpn	73	29	,	,	,
cord-332109-ont0tqpn	73	30	10,649	10,649	CD
cord-332109-ont0tqpn	73	31	(	(	-LRB-
cord-332109-ont0tqpn	73	32	56.0	56.0	CD
cord-332109-ont0tqpn	73	33	%	%	NN
cord-332109-ont0tqpn	73	34	)	)	-RRB-
cord-332109-ont0tqpn	73	35	had	have	VBD
cord-332109-ont0tqpn	73	36	a	a	DT
cord-332109-ont0tqpn	73	37	record	record	NN
cord-332109-ont0tqpn	73	38	of	of	IN
cord-332109-ont0tqpn	73	39	receiving	receive	VBG
cord-332109-ont0tqpn	73	40	social	social	JJ
cord-332109-ont0tqpn	73	41	assistance	assistance	NN
cord-332109-ont0tqpn	73	42	,	,	,
cord-332109-ont0tqpn	73	43	and	and	CC
cord-332109-ont0tqpn	73	44	5716	5716	CD
cord-332109-ont0tqpn	73	45	(	(	-LRB-
cord-332109-ont0tqpn	73	46	30.0	30.0	CD
cord-332109-ont0tqpn	73	47	%	%	NN
cord-332109-ont0tqpn	73	48	)	)	-RRB-
cord-332109-ont0tqpn	73	49	had	have	VBD
cord-332109-ont0tqpn	73	50	no	no	DT
cord-332109-ont0tqpn	73	51	fixed	fix	VBN
cord-332109-ont0tqpn	73	52	address	address	NN
cord-332109-ont0tqpn	73	53	record	record	NN
cord-332109-ont0tqpn	73	54	.	.	.
cord-332109-ont0tqpn	74	1	These	these	DT
cord-332109-ont0tqpn	74	2	individuals	individual	NNS
cord-332109-ont0tqpn	74	3	with	with	IN
cord-332109-ont0tqpn	74	4	a	a	DT
cord-332109-ont0tqpn	74	5	history	history	NN
cord-332109-ont0tqpn	74	6	of	of	IN
cord-332109-ont0tqpn	74	7	overdose	overdose	NN
cord-332109-ont0tqpn	74	8	are	be	VBP
cord-332109-ont0tqpn	74	9	more	more	RBR
cord-332109-ont0tqpn	74	10	likely	likely	JJ
cord-332109-ont0tqpn	74	11	to	to	TO
cord-332109-ont0tqpn	74	12	have	have	VB
cord-332109-ont0tqpn	74	13	at	at	RB
cord-332109-ont0tqpn	74	14	least	least	RBS
cord-332109-ont0tqpn	74	15	three	three	CD
cord-332109-ont0tqpn	74	16	known	know	VBN
cord-332109-ont0tqpn	74	17	chronical	chronical	JJ
cord-332109-ont0tqpn	74	18	conditions	condition	NNS
cord-332109-ont0tqpn	74	19	associated	associate	VBN
cord-332109-ont0tqpn	74	20	with	with	IN
cord-332109-ont0tqpn	74	21	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	74	22	severity	severity	NN
cord-332109-ont0tqpn	74	23	,	,	,
cord-332109-ont0tqpn	74	24	including	include	VBG
cord-332109-ont0tqpn	74	25	chronical	chronical	JJ
cord-332109-ont0tqpn	74	26	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	74	27	disease	disease	NN
cord-332109-ont0tqpn	74	28	,	,	,
cord-332109-ont0tqpn	74	29	diabetes	diabetes	NN
cord-332109-ont0tqpn	74	30	,	,	,
cord-332109-ont0tqpn	74	31	and	and	CC
cord-332109-ont0tqpn	74	32	coronary	coronary	JJ
cord-332109-ont0tqpn	74	33	heart	heart	NN
cord-332109-ont0tqpn	74	34	disease	disease	NN
cord-332109-ont0tqpn	74	35	,	,	,
cord-332109-ont0tqpn	74	36	with	with	IN
cord-332109-ont0tqpn	74	37	adjusted	adjust	VBN
cord-332109-ont0tqpn	74	38	odds	odd	NNS
cord-332109-ont0tqpn	74	39	ratios	ratio	NNS
cord-332109-ont0tqpn	74	40	(	(	-LRB-
cord-332109-ont0tqpn	74	41	ORs	or	NNS
cord-332109-ont0tqpn	74	42	)	)	-RRB-
cord-332109-ont0tqpn	74	43	to	to	TO
cord-332109-ont0tqpn	74	44	be	be	VB
cord-332109-ont0tqpn	74	45	2.01	2.01	CD
cord-332109-ont0tqpn	74	46	,	,	,
cord-332109-ont0tqpn	74	47	1.24	1.24	CD
cord-332109-ont0tqpn	74	48	and	and	CC
cord-332109-ont0tqpn	74	49	2.08	2.08	CD
cord-332109-ont0tqpn	74	50	,	,	,
cord-332109-ont0tqpn	74	51	respectively	respectively	RB
cord-332109-ont0tqpn	74	52	,	,	,
cord-332109-ont0tqpn	74	53	with	with	IN
cord-332109-ont0tqpn	74	54	reference	reference	NN
cord-332109-ont0tqpn	74	55	to	to	IN
cord-332109-ont0tqpn	74	56	people	people	NNS
cord-332109-ont0tqpn	74	57	without	without	IN
cord-332109-ont0tqpn	74	58	an	an	DT
cord-332109-ont0tqpn	74	59	overdose	overdose	NN
cord-332109-ont0tqpn	74	60	[	[	-LRB-
cord-332109-ont0tqpn	74	61	39	39	CD
cord-332109-ont0tqpn	74	62	]	]	-RRB-
cord-332109-ont0tqpn	74	63	.	.	.
cord-332109-ont0tqpn	75	1	During	during	IN
cord-332109-ont0tqpn	75	2	the	the	DT
cord-332109-ont0tqpn	75	3	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	75	4	pandemic	pandemic	NN
cord-332109-ont0tqpn	75	5	,	,	,
cord-332109-ont0tqpn	75	6	risks	risk	NNS
cord-332109-ont0tqpn	75	7	of	of	IN
cord-332109-ont0tqpn	75	8	abusing	abuse	VBG
cord-332109-ont0tqpn	75	9	substances	substance	NNS
cord-332109-ont0tqpn	75	10	and	and	CC
cord-332109-ont0tqpn	75	11	addictive	addictive	JJ
cord-332109-ont0tqpn	75	12	behaviors	behavior	NNS
cord-332109-ont0tqpn	75	13	are	be	VBP
cord-332109-ont0tqpn	75	14	also	also	RB
cord-332109-ont0tqpn	75	15	increasing	increase	VBG
cord-332109-ont0tqpn	75	16	.	.	.
cord-332109-ont0tqpn	76	1	The	the	DT
cord-332109-ont0tqpn	76	2	stress	stress	NN
cord-332109-ont0tqpn	76	3	and	and	CC
cord-332109-ont0tqpn	76	4	social	social	JJ
cord-332109-ont0tqpn	76	5	isolation	isolation	NN
cord-332109-ont0tqpn	76	6	associated	associate	VBN
cord-332109-ont0tqpn	76	7	with	with	IN
cord-332109-ont0tqpn	76	8	the	the	DT
cord-332109-ont0tqpn	76	9	response	response	NN
cord-332109-ont0tqpn	76	10	to	to	IN
cord-332109-ont0tqpn	76	11	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	76	12	increases	increase	NNS
cord-332109-ont0tqpn	76	13	the	the	DT
cord-332109-ont0tqpn	76	14	risk	risk	NN
cord-332109-ont0tqpn	76	15	of	of	IN
cord-332109-ont0tqpn	76	16	alcohol	alcohol	NN
cord-332109-ont0tqpn	76	17	abuse	abuse	NN
cord-332109-ont0tqpn	76	18	and	and	CC
cord-332109-ont0tqpn	76	19	misuse	misuse	NN
cord-332109-ont0tqpn	76	20	,	,	,
cord-332109-ont0tqpn	76	21	which	which	WDT
cord-332109-ont0tqpn	76	22	is	be	VBZ
cord-332109-ont0tqpn	76	23	known	know	VBN
cord-332109-ont0tqpn	76	24	to	to	TO
cord-332109-ont0tqpn	76	25	suppress	suppress	VB
cord-332109-ont0tqpn	76	26	immune	immune	JJ
cord-332109-ont0tqpn	76	27	systems	system	NNS
cord-332109-ont0tqpn	76	28	and	and	CC
cord-332109-ont0tqpn	76	29	cause	cause	VB
cord-332109-ont0tqpn	76	30	emotional	emotional	JJ
cord-332109-ont0tqpn	76	31	dysregulation	dysregulation	NN
cord-332109-ont0tqpn	76	32	[	[	-LRB-
cord-332109-ont0tqpn	76	33	40	40	CD
cord-332109-ont0tqpn	76	34	]	]	-RRB-
cord-332109-ont0tqpn	76	35	.	.	.
cord-332109-ont0tqpn	77	1	A	a	DT
cord-332109-ont0tqpn	77	2	study	study	NN
cord-332109-ont0tqpn	77	3	in	in	IN
cord-332109-ont0tqpn	77	4	China	China	NNP
cord-332109-ont0tqpn	77	5	showed	show	VBD
cord-332109-ont0tqpn	77	6	that	that	IN
cord-332109-ont0tqpn	77	7	relapses	relapse	NNS
cord-332109-ont0tqpn	77	8	of	of	IN
cord-332109-ont0tqpn	77	9	alcohol	alcohol	NN
cord-332109-ont0tqpn	77	10	and	and	CC
cord-332109-ont0tqpn	77	11	smoking	smoking	NN
cord-332109-ont0tqpn	77	12	abuse	abuse	NN
cord-332109-ont0tqpn	77	13	were	be	VBD
cord-332109-ont0tqpn	77	14	prominent	prominent	JJ
cord-332109-ont0tqpn	77	15	(	(	-LRB-
cord-332109-ont0tqpn	77	16	18.7	18.7	CD
cord-332109-ont0tqpn	77	17	%	%	NN
cord-332109-ont0tqpn	77	18	and	and	CC
cord-332109-ont0tqpn	77	19	25.3	25.3	CD
cord-332109-ont0tqpn	77	20	%	%	NN
cord-332109-ont0tqpn	77	21	,	,	,
cord-332109-ont0tqpn	77	22	respectively	respectively	RB
cord-332109-ont0tqpn	77	23	)	)	-RRB-
cord-332109-ont0tqpn	77	24	,	,	,
cord-332109-ont0tqpn	77	25	and	and	CC
cord-332109-ont0tqpn	77	26	32.1	32.1	CD
cord-332109-ont0tqpn	77	27	%	%	NN
cord-332109-ont0tqpn	77	28	of	of	IN
cord-332109-ont0tqpn	77	29	regular	regular	JJ
cord-332109-ont0tqpn	77	30	drinkers	drinker	NNS
cord-332109-ont0tqpn	77	31	and	and	CC
cord-332109-ont0tqpn	77	32	19.7	19.7	CD
cord-332109-ont0tqpn	77	33	%	%	NN
cord-332109-ont0tqpn	77	34	of	of	IN
cord-332109-ont0tqpn	77	35	regular	regular	JJ
cord-332109-ont0tqpn	77	36	smokers	smoker	NNS
cord-332109-ont0tqpn	77	37	increased	increase	VBD
cord-332109-ont0tqpn	77	38	alcohol	alcohol	NN
cord-332109-ont0tqpn	77	39	and	and	CC
cord-332109-ont0tqpn	77	40	cigarette	cigarette	NN
cord-332109-ont0tqpn	77	41	consumption	consumption	NN
cord-332109-ont0tqpn	77	42	[	[	-LRB-
cord-332109-ont0tqpn	77	43	41	41	CD
cord-332109-ont0tqpn	77	44	]	]	-RRB-
cord-332109-ont0tqpn	77	45	.	.	.
cord-332109-ont0tqpn	78	1	SARS	SARS	NNP
cord-332109-ont0tqpn	78	2	-	-	HYPH
cord-332109-ont0tqpn	78	3	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	78	4	can	can	MD
cord-332109-ont0tqpn	78	5	attack	attack	VB
cord-332109-ont0tqpn	78	6	and	and	CC
cord-332109-ont0tqpn	78	7	damage	damage	VB
cord-332109-ont0tqpn	78	8	human	human	JJ
cord-332109-ont0tqpn	78	9	organs	organ	NNS
cord-332109-ont0tqpn	78	10	through	through	IN
cord-332109-ont0tqpn	78	11	two	two	CD
cord-332109-ont0tqpn	78	12	major	major	JJ
cord-332109-ont0tqpn	78	13	events	event	NNS
cord-332109-ont0tqpn	78	14	:	:	:
cord-332109-ont0tqpn	78	15	direct	direct	JJ
cord-332109-ont0tqpn	78	16	viral	viral	JJ
cord-332109-ont0tqpn	78	17	attacks	attack	NNS
cord-332109-ont0tqpn	78	18	against	against	IN
cord-332109-ont0tqpn	78	19	target	target	NN
cord-332109-ont0tqpn	78	20	organs	organ	NNS
cord-332109-ont0tqpn	78	21	and	and	CC
cord-332109-ont0tqpn	78	22	abnormal	abnormal	JJ
cord-332109-ont0tqpn	78	23	immune	immune	JJ
cord-332109-ont0tqpn	78	24	responses	response	NNS
cord-332109-ont0tqpn	78	25	and	and	CC
cord-332109-ont0tqpn	78	26	inflammation	inflammation	NN
cord-332109-ont0tqpn	78	27	[	[	-LRB-
cord-332109-ont0tqpn	78	28	42	42	CD
cord-332109-ont0tqpn	78	29	]	]	-RRB-
cord-332109-ont0tqpn	78	30	.	.	.
cord-332109-ont0tqpn	79	1	Initial	initial	JJ
cord-332109-ont0tqpn	79	2	evidence	evidence	NN
cord-332109-ont0tqpn	79	3	focuses	focus	VBZ
cord-332109-ont0tqpn	79	4	on	on	IN
cord-332109-ont0tqpn	79	5	the	the	DT
cord-332109-ont0tqpn	79	6	damage	damage	NN
cord-332109-ont0tqpn	79	7	to	to	IN
cord-332109-ont0tqpn	79	8	the	the	DT
cord-332109-ont0tqpn	79	9	respiratory	respiratory	JJ
cord-332109-ont0tqpn	79	10	system	system	NN
cord-332109-ont0tqpn	79	11	and	and	CC
cord-332109-ont0tqpn	79	12	the	the	DT
cord-332109-ont0tqpn	79	13	lung	lung	NN
cord-332109-ont0tqpn	79	14	,	,	,
cord-332109-ont0tqpn	79	15	and	and	CC
cord-332109-ont0tqpn	79	16	is	be	VBZ
cord-332109-ont0tqpn	79	17	correlated	correlate	VBN
cord-332109-ont0tqpn	79	18	with	with	IN
cord-332109-ont0tqpn	79	19	clinical	clinical	JJ
cord-332109-ont0tqpn	79	20	symptoms	symptom	NNS
cord-332109-ont0tqpn	79	21	of	of	IN
cord-332109-ont0tqpn	79	22	the	the	DT
cord-332109-ont0tqpn	79	23	patients	patient	NNS
cord-332109-ont0tqpn	79	24	[	[	-LRB-
cord-332109-ont0tqpn	79	25	2	2	CD
cord-332109-ont0tqpn	79	26	,	,	,
cord-332109-ont0tqpn	79	27	12	12	CD
cord-332109-ont0tqpn	79	28	,	,	,
cord-332109-ont0tqpn	79	29	20	20	CD
cord-332109-ont0tqpn	79	30	,	,	,
cord-332109-ont0tqpn	79	31	21	21	CD
cord-332109-ont0tqpn	79	32	]	]	-RRB-
cord-332109-ont0tqpn	79	33	.	.	.
cord-332109-ont0tqpn	80	1	The	the	DT
cord-332109-ont0tqpn	80	2	identified	identify	VBN
cord-332109-ont0tqpn	80	3	viral	viral	JJ
cord-332109-ont0tqpn	80	4	entry	entry	NN
cord-332109-ont0tqpn	80	5	receptor	receptor	NN
cord-332109-ont0tqpn	80	6	,	,	,
cord-332109-ont0tqpn	80	7	ACE2	ACE2	NNP
cord-332109-ont0tqpn	80	8	,	,	,
cord-332109-ont0tqpn	80	9	is	be	VBZ
cord-332109-ont0tqpn	80	10	abundantly	abundantly	RB
cord-332109-ont0tqpn	80	11	expressed	express	VBN
cord-332109-ont0tqpn	80	12	in	in	IN
cord-332109-ont0tqpn	80	13	the	the	DT
cord-332109-ont0tqpn	80	14	epithelial	epithelial	JJ
cord-332109-ont0tqpn	80	15	cells	cell	NNS
cord-332109-ont0tqpn	80	16	along	along	IN
cord-332109-ont0tqpn	80	17	the	the	DT
cord-332109-ont0tqpn	80	18	respiratory	respiratory	JJ
cord-332109-ont0tqpn	80	19	tract	tract	NN
cord-332109-ont0tqpn	80	20	and	and	CC
cord-332109-ont0tqpn	80	21	the	the	DT
cord-332109-ont0tqpn	80	22	lung	lung	NN
cord-332109-ont0tqpn	80	23	alveoli	alveolus	NNS
cord-332109-ont0tqpn	80	24	[	[	-LRB-
cord-332109-ont0tqpn	80	25	29	29	CD
cord-332109-ont0tqpn	80	26	,	,	,
cord-332109-ont0tqpn	80	27	43	43	CD
cord-332109-ont0tqpn	80	28	,	,	,
cord-332109-ont0tqpn	80	29	44	44	CD
cord-332109-ont0tqpn	80	30	]	]	-RRB-
cord-332109-ont0tqpn	80	31	.	.	.
cord-332109-ont0tqpn	81	1	High	high	JJ
cord-332109-ont0tqpn	81	2	level	level	NN
cord-332109-ont0tqpn	81	3	expression	expression	NN
cord-332109-ont0tqpn	81	4	of	of	IN
cord-332109-ont0tqpn	81	5	ACE2	ACE2	NNP
cord-332109-ont0tqpn	81	6	receptors	receptor	NNS
cord-332109-ont0tqpn	81	7	is	be	VBZ
cord-332109-ont0tqpn	81	8	also	also	RB
cord-332109-ont0tqpn	81	9	reported	report	VBN
cord-332109-ont0tqpn	81	10	in	in	IN
cord-332109-ont0tqpn	81	11	organs	organ	NNS
cord-332109-ont0tqpn	81	12	and	and	CC
cord-332109-ont0tqpn	81	13	tissues	tissue	NNS
cord-332109-ont0tqpn	81	14	outside	outside	IN
cord-332109-ont0tqpn	81	15	the	the	DT
cord-332109-ont0tqpn	81	16	respiratory	respiratory	JJ
cord-332109-ont0tqpn	81	17	system	system	NN
cord-332109-ont0tqpn	81	18	,	,	,
cord-332109-ont0tqpn	81	19	including	include	VBG
cord-332109-ont0tqpn	81	20	the	the	DT
cord-332109-ont0tqpn	81	21	heart	heart	NN
cord-332109-ont0tqpn	81	22	,	,	,
cord-332109-ont0tqpn	81	23	kidney	kidney	NN
cord-332109-ont0tqpn	81	24	,	,	,
cord-332109-ont0tqpn	81	25	and	and	CC
cord-332109-ont0tqpn	81	26	intestine	intestine	NN
cord-332109-ont0tqpn	81	27	[	[	-LRB-
cord-332109-ont0tqpn	81	28	45	45	CD
cord-332109-ont0tqpn	81	29	]	]	-RRB-
cord-332109-ont0tqpn	81	30	.	.	.
cord-332109-ont0tqpn	82	1	Therefore	therefore	RB
cord-332109-ont0tqpn	82	2	,	,	,
cord-332109-ont0tqpn	82	3	these	these	DT
cord-332109-ont0tqpn	82	4	organs	organ	NNS
cord-332109-ont0tqpn	82	5	are	be	VBP
cord-332109-ont0tqpn	82	6	the	the	DT
cord-332109-ont0tqpn	82	7	potential	potential	JJ
cord-332109-ont0tqpn	82	8	targets	target	NNS
cord-332109-ont0tqpn	82	9	of	of	IN
cord-332109-ont0tqpn	82	10	and	and	CC
cord-332109-ont0tqpn	82	11	could	could	MD
cord-332109-ont0tqpn	82	12	be	be	VB
cord-332109-ont0tqpn	82	13	damaged	damage	VBN
cord-332109-ont0tqpn	82	14	by	by	IN
cord-332109-ont0tqpn	82	15	SARS	SARS	NNP
cord-332109-ont0tqpn	82	16	-	-	HYPH
cord-332109-ont0tqpn	82	17	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	82	18	.	.	.
cord-332109-ont0tqpn	83	1	As	as	IN
cord-332109-ont0tqpn	83	2	mentioned	mention	VBN
cord-332109-ont0tqpn	83	3	earlier	early	RBR
cord-332109-ont0tqpn	83	4	,	,	,
cord-332109-ont0tqpn	83	5	smoking	smoking	NN
cord-332109-ont0tqpn	83	6	of	of	IN
cord-332109-ont0tqpn	83	7	tobacco	tobacco	NN
cord-332109-ont0tqpn	83	8	and	and	CC
cord-332109-ont0tqpn	83	9	marijuana	marijuana	NN
cord-332109-ont0tqpn	83	10	directly	directly	RB
cord-332109-ont0tqpn	83	11	impairs	impair	VBZ
cord-332109-ont0tqpn	83	12	respiratory	respiratory	JJ
cord-332109-ont0tqpn	83	13	system	system	NN
cord-332109-ont0tqpn	83	14	.	.	.
cord-332109-ont0tqpn	84	1	Other	other	JJ
cord-332109-ont0tqpn	84	2	substances	substance	NNS
cord-332109-ont0tqpn	84	3	of	of	IN
cord-332109-ont0tqpn	84	4	abuse	abuse	NN
cord-332109-ont0tqpn	84	5	can	can	MD
cord-332109-ont0tqpn	84	6	cause	cause	VB
cord-332109-ont0tqpn	84	7	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	84	8	diseases	disease	NNS
cord-332109-ont0tqpn	84	9	,	,	,
cord-332109-ont0tqpn	84	10	which	which	WDT
cord-332109-ont0tqpn	84	11	amplify	amplify	VBP
cord-332109-ont0tqpn	84	12	respiratory	respiratory	JJ
cord-332109-ont0tqpn	84	13	and	and	CC
cord-332109-ont0tqpn	84	14	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	84	15	complications	complication	NNS
cord-332109-ont0tqpn	84	16	.	.	.
cord-332109-ont0tqpn	85	1	We	-PRON-	PRP
cord-332109-ont0tqpn	85	2	will	will	MD
cord-332109-ont0tqpn	85	3	discuss	discuss	VB
cord-332109-ont0tqpn	85	4	these	these	DT
cord-332109-ont0tqpn	85	5	complications	complication	NNS
cord-332109-ont0tqpn	85	6	in	in	IN
cord-332109-ont0tqpn	85	7	the	the	DT
cord-332109-ont0tqpn	85	8	next	next	JJ
cord-332109-ont0tqpn	85	9	section	section	NN
cord-332109-ont0tqpn	85	10	.	.	.
cord-332109-ont0tqpn	86	1	More	more	RBR
cord-332109-ont0tqpn	86	2	severely	severely	RB
cord-332109-ont0tqpn	86	3	,	,	,
cord-332109-ont0tqpn	86	4	ACE2	ACE2	NNP
cord-332109-ont0tqpn	86	5	is	be	VBZ
cord-332109-ont0tqpn	86	6	abundantly	abundantly	RB
cord-332109-ont0tqpn	86	7	expressed	express	VBN
cord-332109-ont0tqpn	86	8	in	in	IN
cord-332109-ont0tqpn	86	9	vascular	vascular	JJ
cord-332109-ont0tqpn	86	10	endothelial	endothelial	JJ
cord-332109-ont0tqpn	86	11	cells	cell	NNS
cord-332109-ont0tqpn	86	12	[	[	-LRB-
cord-332109-ont0tqpn	86	13	45	45	CD
cord-332109-ont0tqpn	86	14	]	]	-RRB-
cord-332109-ont0tqpn	86	15	.	.	.
cord-332109-ont0tqpn	87	1	Several	several	JJ
cord-332109-ont0tqpn	87	2	clinical	clinical	JJ
cord-332109-ont0tqpn	87	3	cases	case	NNS
cord-332109-ont0tqpn	87	4	have	have	VBP
cord-332109-ont0tqpn	87	5	been	be	VBN
cord-332109-ont0tqpn	87	6	reported	report	VBN
cord-332109-ont0tqpn	87	7	to	to	TO
cord-332109-ont0tqpn	87	8	indicate	indicate	VB
cord-332109-ont0tqpn	87	9	direct	direct	JJ
cord-332109-ont0tqpn	87	10	involvement	involvement	NN
cord-332109-ont0tqpn	87	11	of	of	IN
cord-332109-ont0tqpn	87	12	vascular	vascular	JJ
cord-332109-ont0tqpn	87	13	endothelial	endothelial	JJ
cord-332109-ont0tqpn	87	14	cells	cell	NNS
cord-332109-ont0tqpn	87	15	in	in	IN
cord-332109-ont0tqpn	87	16	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	87	17	pathology	pathology	NN
cord-332109-ont0tqpn	87	18	at	at	IN
cord-332109-ont0tqpn	87	19	different	different	JJ
cord-332109-ont0tqpn	87	20	organs	organ	NNS
cord-332109-ont0tqpn	87	21	,	,	,
cord-332109-ont0tqpn	87	22	suggesting	suggest	VBG
cord-332109-ont0tqpn	87	23	that	that	IN
cord-332109-ont0tqpn	87	24	the	the	DT
cord-332109-ont0tqpn	87	25	damages	damage	NNS
cord-332109-ont0tqpn	87	26	to	to	IN
cord-332109-ont0tqpn	87	27	the	the	DT
cord-332109-ont0tqpn	87	28	lung	lung	NN
cord-332109-ont0tqpn	87	29	,	,	,
cord-332109-ont0tqpn	87	30	heart	heart	NN
cord-332109-ont0tqpn	87	31	,	,	,
cord-332109-ont0tqpn	87	32	kidney	kidney	NN
cord-332109-ont0tqpn	87	33	,	,	,
cord-332109-ont0tqpn	87	34	liver	liver	NN
cord-332109-ont0tqpn	87	35	,	,	,
cord-332109-ont0tqpn	87	36	small	small	JJ
cord-332109-ont0tqpn	87	37	intestine	intestine	NN
cord-332109-ont0tqpn	87	38	,	,	,
cord-332109-ont0tqpn	87	39	and	and	CC
cord-332109-ont0tqpn	87	40	bowel	bowel	NN
cord-332109-ont0tqpn	87	41	,	,	,
cord-332109-ont0tqpn	87	42	are	be	VBP
cord-332109-ont0tqpn	87	43	actually	actually	RB
cord-332109-ont0tqpn	87	44	caused	cause	VBN
cord-332109-ont0tqpn	87	45	by	by	IN
cord-332109-ont0tqpn	87	46	endotheliitis	endotheliitis	NNP
cord-332109-ont0tqpn	87	47	(	(	-LRB-
cord-332109-ont0tqpn	87	48	endothelialitis	endothelialitis	NNP
cord-332109-ont0tqpn	87	49	)	)	-RRB-
cord-332109-ont0tqpn	87	50	.	.	.
cord-332109-ont0tqpn	88	1	Direct	direct	JJ
cord-332109-ont0tqpn	88	2	viral	viral	JJ
cord-332109-ont0tqpn	88	3	infection	infection	NN
cord-332109-ont0tqpn	88	4	of	of	IN
cord-332109-ont0tqpn	88	5	endothelial	endothelial	JJ
cord-332109-ont0tqpn	88	6	cells	cell	NNS
cord-332109-ont0tqpn	88	7	induces	induce	VBZ
cord-332109-ont0tqpn	88	8	inflammation	inflammation	NN
cord-332109-ont0tqpn	88	9	and	and	CC
cord-332109-ont0tqpn	88	10	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	88	11	cell	cell	NN
cord-332109-ont0tqpn	88	12	death	death	NN
cord-332109-ont0tqpn	88	13	at	at	IN
cord-332109-ont0tqpn	88	14	the	the	DT
cord-332109-ont0tqpn	88	15	endothelium	endothelium	NN
cord-332109-ont0tqpn	88	16	(	(	-LRB-
cord-332109-ont0tqpn	88	17	Figure	figure	NN
cord-332109-ont0tqpn	88	18	2	2	CD
cord-332109-ont0tqpn	88	19	)	)	-RRB-
cord-332109-ont0tqpn	88	20	[	[	-LRB-
cord-332109-ont0tqpn	88	21	46	46	CD
cord-332109-ont0tqpn	88	22	]	]	-RRB-
cord-332109-ont0tqpn	88	23	.	.	.
cord-332109-ont0tqpn	89	1	Comparing	compare	VBG
cord-332109-ont0tqpn	89	2	lung	lung	NN
cord-332109-ont0tqpn	89	3	tissues	tissue	NNS
cord-332109-ont0tqpn	89	4	from	from	IN
cord-332109-ont0tqpn	89	5	deceased	deceased	JJ
cord-332109-ont0tqpn	89	6	patients	patient	NNS
cord-332109-ont0tqpn	89	7	of	of	IN
cord-332109-ont0tqpn	89	8	acute	acute	JJ
cord-332109-ont0tqpn	89	9	respiratory	respiratory	JJ
cord-332109-ont0tqpn	89	10	distress	distress	NN
cord-332109-ont0tqpn	89	11	syndrome	syndrome	NN
cord-332109-ont0tqpn	89	12	(	(	-LRB-
cord-332109-ont0tqpn	89	13	ARDS	ARDS	NNP
cord-332109-ont0tqpn	89	14	)	)	-RRB-
cord-332109-ont0tqpn	89	15	associated	associate	VBN
cord-332109-ont0tqpn	89	16	with	with	IN
cord-332109-ont0tqpn	89	17	influenza	influenza	NN
cord-332109-ont0tqpn	89	18	and	and	CC
cord-332109-ont0tqpn	89	19	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	89	20	,	,	,
cord-332109-ont0tqpn	89	21	the	the	DT
cord-332109-ont0tqpn	89	22	lungs	lung	NNS
cord-332109-ont0tqpn	89	23	from	from	IN
cord-332109-ont0tqpn	89	24	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	89	25	patients	patient	NNS
cord-332109-ont0tqpn	89	26	displayed	display	VBD
cord-332109-ont0tqpn	89	27	distinctive	distinctive	JJ
cord-332109-ont0tqpn	89	28	vascular	vascular	JJ
cord-332109-ont0tqpn	89	29	impairments	impairment	NNS
cord-332109-ont0tqpn	89	30	of	of	IN
cord-332109-ont0tqpn	89	31	the	the	DT
cord-332109-ont0tqpn	89	32	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	89	33	vessels	vessel	NNS
cord-332109-ont0tqpn	89	34	.	.	.
cord-332109-ont0tqpn	90	1	Most	most	RBS
cord-332109-ont0tqpn	90	2	significantly	significantly	RB
cord-332109-ont0tqpn	90	3	,	,	,
cord-332109-ont0tqpn	90	4	viruses	virus	NNS
cord-332109-ont0tqpn	90	5	were	be	VBD
cord-332109-ont0tqpn	90	6	found	find	VBN
cord-332109-ont0tqpn	90	7	inside	inside	IN
cord-332109-ont0tqpn	90	8	the	the	DT
cord-332109-ont0tqpn	90	9	endothelial	endothelial	JJ
cord-332109-ont0tqpn	90	10	cells	cell	NNS
cord-332109-ont0tqpn	90	11	of	of	IN
cord-332109-ont0tqpn	90	12	the	the	DT
cord-332109-ont0tqpn	90	13	lung	lung	NN
cord-332109-ont0tqpn	90	14	tissues	tissue	NNS
cord-332109-ont0tqpn	90	15	from	from	IN
cord-332109-ont0tqpn	90	16	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	90	17	patients	patient	NNS
cord-332109-ont0tqpn	90	18	,	,	,
cord-332109-ont0tqpn	90	19	which	which	WDT
cord-332109-ont0tqpn	90	20	disrupted	disrupt	VBD
cord-332109-ont0tqpn	90	21	cell	cell	NN
cord-332109-ont0tqpn	90	22	membrane	membrane	NN
cord-332109-ont0tqpn	90	23	,	,	,
cord-332109-ont0tqpn	90	24	caused	cause	VBD
cord-332109-ont0tqpn	90	25	prevalent	prevalent	JJ
cord-332109-ont0tqpn	90	26	thrombosis	thrombosis	NN
cord-332109-ont0tqpn	90	27	with	with	IN
cord-332109-ont0tqpn	90	28	microangiopathy	microangiopathy	NNP
cord-332109-ont0tqpn	90	29	,	,	,
cord-332109-ont0tqpn	90	30	and	and	CC
cord-332109-ont0tqpn	90	31	induced	induce	VBD
cord-332109-ont0tqpn	90	32	elevated	elevated	JJ
cord-332109-ont0tqpn	90	33	intussusceptive	intussusceptive	JJ
cord-332109-ont0tqpn	90	34	angiogenesis	angiogenesis	NN
cord-332109-ont0tqpn	90	35	[	[	-LRB-
cord-332109-ont0tqpn	90	36	47	47	CD
cord-332109-ont0tqpn	90	37	]	]	-RRB-
cord-332109-ont0tqpn	90	38	.	.	.
cord-332109-ont0tqpn	91	1	A	a	DT
cord-332109-ont0tqpn	91	2	greater	great	JJR
cord-332109-ont0tqpn	91	3	number	number	NN
cord-332109-ont0tqpn	91	4	of	of	IN
cord-332109-ont0tqpn	91	5	ACE2	ACE2	NNP
cord-332109-ont0tqpn	91	6	+	+	CC
cord-332109-ont0tqpn	91	7	endothelial	endothelial	JJ
cord-332109-ont0tqpn	91	8	cells	cell	NNS
cord-332109-ont0tqpn	91	9	were	be	VBD
cord-332109-ont0tqpn	91	10	found	find	VBN
cord-332109-ont0tqpn	91	11	in	in	IN
cord-332109-ont0tqpn	91	12	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	91	13	patients	patient	NNS
cord-332109-ont0tqpn	91	14	,	,	,
cord-332109-ont0tqpn	91	15	correlating	correlate	VBG
cord-332109-ont0tqpn	91	16	to	to	IN
cord-332109-ont0tqpn	91	17	changes	change	NNS
cord-332109-ont0tqpn	91	18	in	in	IN
cord-332109-ont0tqpn	91	19	endothelial	endothelial	JJ
cord-332109-ont0tqpn	91	20	morphology	morphology	NN
cord-332109-ont0tqpn	91	21	,	,	,
cord-332109-ont0tqpn	91	22	including	include	VBG
cord-332109-ont0tqpn	91	23	disruption	disruption	NN
cord-332109-ont0tqpn	91	24	of	of	IN
cord-332109-ont0tqpn	91	25	endothelial	endothelial	JJ
cord-332109-ont0tqpn	91	26	cell	cell	NN
cord-332109-ont0tqpn	91	27	junctions	junction	NNS
cord-332109-ont0tqpn	91	28	,	,	,
cord-332109-ont0tqpn	91	29	cell	cell	NN
cord-332109-ont0tqpn	91	30	swelling	swelling	NN
cord-332109-ont0tqpn	91	31	,	,	,
cord-332109-ont0tqpn	91	32	and	and	CC
cord-332109-ont0tqpn	91	33	detachment	detachment	NN
cord-332109-ont0tqpn	91	34	from	from	IN
cord-332109-ont0tqpn	91	35	the	the	DT
cord-332109-ont0tqpn	91	36	basal	basal	NN
cord-332109-ont0tqpn	91	37	membrane	membrane	NN
cord-332109-ont0tqpn	91	38	.	.	.
cord-332109-ont0tqpn	92	1	The	the	DT
cord-332109-ont0tqpn	92	2	presence	presence	NN
cord-332109-ont0tqpn	92	3	of	of	IN
cord-332109-ont0tqpn	92	4	the	the	DT
cord-332109-ont0tqpn	92	5	SARS	SARS	NNP
cord-332109-ont0tqpn	92	6	-	-	HYPH
cord-332109-ont0tqpn	92	7	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	92	8	virus	virus	NN
cord-332109-ont0tqpn	92	9	inside	inside	IN
cord-332109-ont0tqpn	92	10	the	the	DT
cord-332109-ont0tqpn	92	11	endothelial	endothelial	JJ
cord-332109-ont0tqpn	92	12	cells	cell	NNS
cord-332109-ont0tqpn	92	13	,	,	,
cord-332109-ont0tqpn	92	14	together	together	RB
cord-332109-ont0tqpn	92	15	with	with	IN
cord-332109-ont0tqpn	92	16	the	the	DT
cord-332109-ont0tqpn	92	17	induced	induce	VBN
cord-332109-ont0tqpn	92	18	inflammation	inflammation	NN
cord-332109-ont0tqpn	92	19	,	,	,
cord-332109-ont0tqpn	92	20	may	may	MD
cord-332109-ont0tqpn	92	21	directly	directly	RB
cord-332109-ont0tqpn	92	22	contribute	contribute	VB
cord-332109-ont0tqpn	92	23	to	to	IN
cord-332109-ont0tqpn	92	24	the	the	DT
cord-332109-ont0tqpn	92	25	endothelial	endothelial	JJ
cord-332109-ont0tqpn	92	26	injury	injury	NN
cord-332109-ont0tqpn	92	27	[	[	-LRB-
cord-332109-ont0tqpn	92	28	46	46	CD
cord-332109-ont0tqpn	92	29	,	,	,
cord-332109-ont0tqpn	92	30	47	47	CD
cord-332109-ont0tqpn	92	31	]	]	-RRB-
cord-332109-ont0tqpn	92	32	.	.	.
cord-332109-ont0tqpn	93	1	Although	although	IN
cord-332109-ont0tqpn	93	2	there	there	EX
cord-332109-ont0tqpn	93	3	are	be	VBP
cord-332109-ont0tqpn	93	4	no	no	RB
cord-332109-ont0tqpn	93	5	reported	report	VBN
cord-332109-ont0tqpn	93	6	cases	case	NNS
cord-332109-ont0tqpn	93	7	yet	yet	RB
cord-332109-ont0tqpn	93	8	,	,	,
cord-332109-ont0tqpn	93	9	one	one	CD
cord-332109-ont0tqpn	93	10	potential	potential	JJ
cord-332109-ont0tqpn	93	11	target	target	NN
cord-332109-ont0tqpn	93	12	of	of	IN
cord-332109-ont0tqpn	93	13	SARS	SARS	NNP
cord-332109-ont0tqpn	93	14	-	-	HYPH
cord-332109-ont0tqpn	93	15	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	93	16	infection	infection	NN
cord-332109-ont0tqpn	93	17	is	be	VBZ
cord-332109-ont0tqpn	93	18	the	the	DT
cord-332109-ont0tqpn	93	19	brain	brain	NN
cord-332109-ont0tqpn	93	20	microvascular	microvascular	JJ
cord-332109-ont0tqpn	93	21	endothelial	endothelial	JJ
cord-332109-ont0tqpn	93	22	cell	cell	NN
cord-332109-ont0tqpn	93	23	(	(	-LRB-
cord-332109-ont0tqpn	93	24	BMVEC	BMVEC	NNP
cord-332109-ont0tqpn	93	25	)	)	-RRB-
cord-332109-ont0tqpn	93	26	.	.	.
cord-332109-ont0tqpn	94	1	BMVECs	bmvec	NNS
cord-332109-ont0tqpn	94	2	line	line	VBP
cord-332109-ont0tqpn	94	3	up	up	RP
cord-332109-ont0tqpn	94	4	the	the	DT
cord-332109-ont0tqpn	94	5	microcapillary	microcapillary	JJ
cord-332109-ont0tqpn	94	6	beds	bed	NNS
cord-332109-ont0tqpn	94	7	and	and	CC
cord-332109-ont0tqpn	94	8	form	form	VB
cord-332109-ont0tqpn	94	9	the	the	DT
cord-332109-ont0tqpn	94	10	blood	blood	NN
cord-332109-ont0tqpn	94	11	-	-	HYPH
cord-332109-ont0tqpn	94	12	brain	brain	NN
cord-332109-ont0tqpn	94	13	barrier	barrier	NN
cord-332109-ont0tqpn	94	14	(	(	-LRB-
cord-332109-ont0tqpn	94	15	BBB	BBB	NNP
cord-332109-ont0tqpn	94	16	)	)	-RRB-
cord-332109-ont0tqpn	94	17	together	together	RB
cord-332109-ont0tqpn	94	18	with	with	IN
cord-332109-ont0tqpn	94	19	brain	brain	NN
cord-332109-ont0tqpn	94	20	astrocytes	astrocyte	NNS
cord-332109-ont0tqpn	94	21	and	and	CC
cord-332109-ont0tqpn	94	22	pericytes	pericyte	NNS
cord-332109-ont0tqpn	94	23	.	.	.
cord-332109-ont0tqpn	95	1	The	the	DT
cord-332109-ont0tqpn	95	2	BBB	BBB	NNP
cord-332109-ont0tqpn	95	3	prevents	prevent	VBZ
cord-332109-ont0tqpn	95	4	pathogens	pathogen	NNS
cord-332109-ont0tqpn	95	5	and	and	CC
cord-332109-ont0tqpn	95	6	toxins	toxin	NNS
cord-332109-ont0tqpn	95	7	from	from	IN
cord-332109-ont0tqpn	95	8	trespassing	trespassing	NN
cord-332109-ont0tqpn	95	9	into	into	IN
cord-332109-ont0tqpn	95	10	the	the	DT
cord-332109-ont0tqpn	95	11	brain	brain	NN
cord-332109-ont0tqpn	95	12	side	side	NN
cord-332109-ont0tqpn	95	13	.	.	.
cord-332109-ont0tqpn	96	1	Tight	tight	JJ
cord-332109-ont0tqpn	96	2	-	-	HYPH
cord-332109-ont0tqpn	96	3	junction	junction	NN
cord-332109-ont0tqpn	97	1	(	(	-LRB-
cord-332109-ont0tqpn	97	2	TJ	TJ	NNP
cord-332109-ont0tqpn	97	3	)	)	-RRB-
cord-332109-ont0tqpn	97	4	protein	protein	NN
cord-332109-ont0tqpn	97	5	complexes	complex	NNS
cord-332109-ont0tqpn	97	6	,	,	,
cord-332109-ont0tqpn	97	7	composed	compose	VBN
cord-332109-ont0tqpn	97	8	of	of	IN
cord-332109-ont0tqpn	97	9	occludin	occludin	NNP
cord-332109-ont0tqpn	97	10	,	,	,
cord-332109-ont0tqpn	97	11	claudins	claudin	NNS
cord-332109-ont0tqpn	97	12	,	,	,
cord-332109-ont0tqpn	97	13	junctional	junctional	JJ
cord-332109-ont0tqpn	97	14	adhesion	adhesion	NN
cord-332109-ont0tqpn	97	15	molecules	molecule	NNS
cord-332109-ont0tqpn	97	16	(	(	-LRB-
cord-332109-ont0tqpn	97	17	JAMs	jam	NNS
cord-332109-ont0tqpn	97	18	)	)	-RRB-
cord-332109-ont0tqpn	97	19	and	and	CC
cord-332109-ont0tqpn	97	20	membrane	membrane	NN
cord-332109-ont0tqpn	97	21	-	-	HYPH
cord-332109-ont0tqpn	97	22	directed	direct	VBN
cord-332109-ont0tqpn	97	23	scaffolding	scaffolding	NN
cord-332109-ont0tqpn	97	24	protein	protein	NN
cord-332109-ont0tqpn	97	25	zonulae	zonulae	NNP
cord-332109-ont0tqpn	97	26	occludentes	occludentes	NNPS
cord-332109-ont0tqpn	97	27	(	(	-LRB-
cord-332109-ont0tqpn	97	28	ZO	ZO	NNP
cord-332109-ont0tqpn	97	29	)	)	-RRB-
cord-332109-ont0tqpn	97	30	,	,	,
cord-332109-ont0tqpn	97	31	form	form	VB
cord-332109-ont0tqpn	97	32	a	a	DT
cord-332109-ont0tqpn	97	33	physical	physical	JJ
cord-332109-ont0tqpn	97	34	inter	inter	JJ
cord-332109-ont0tqpn	97	35	-	-	JJ
cord-332109-ont0tqpn	97	36	endothelial	endothelial	JJ
cord-332109-ont0tqpn	97	37	barrier	barrier	NN
cord-332109-ont0tqpn	97	38	that	that	WDT
cord-332109-ont0tqpn	97	39	strictly	strictly	RB
cord-332109-ont0tqpn	97	40	controls	control	VBZ
cord-332109-ont0tqpn	97	41	migration	migration	NN
cord-332109-ont0tqpn	97	42	of	of	IN
cord-332109-ont0tqpn	97	43	molecular	molecular	JJ
cord-332109-ont0tqpn	97	44	and	and	CC
cord-332109-ont0tqpn	97	45	cellular	cellular	JJ
cord-332109-ont0tqpn	97	46	contents	content	NNS
cord-332109-ont0tqpn	97	47	from	from	IN
cord-332109-ont0tqpn	97	48	the	the	DT
cord-332109-ont0tqpn	97	49	circulation	circulation	NN
cord-332109-ont0tqpn	97	50	into	into	IN
cord-332109-ont0tqpn	97	51	the	the	DT
cord-332109-ont0tqpn	97	52	brain	brain	NN
cord-332109-ont0tqpn	97	53	(	(	-LRB-
cord-332109-ont0tqpn	97	54	Figure	figure	NN
cord-332109-ont0tqpn	97	55	2	2	CD
cord-332109-ont0tqpn	97	56	)	)	-RRB-
cord-332109-ont0tqpn	97	57	[	[	-LRB-
cord-332109-ont0tqpn	97	58	48	48	CD
cord-332109-ont0tqpn	97	59	,	,	,
cord-332109-ont0tqpn	97	60	49	49	CD
cord-332109-ont0tqpn	97	61	]	]	-RRB-
cord-332109-ont0tqpn	97	62	.	.	.
cord-332109-ont0tqpn	98	1	High	high	JJ
cord-332109-ont0tqpn	98	2	expression	expression	NN
cord-332109-ont0tqpn	98	3	of	of	IN
cord-332109-ont0tqpn	98	4	efflux	efflux	NN
cord-332109-ont0tqpn	98	5	pumps	pump	NNS
cord-332109-ont0tqpn	98	6	and	and	CC
cord-332109-ont0tqpn	98	7	stereospecific	stereospecific	NN
cord-332109-ont0tqpn	98	8	solute	solute	NN
cord-332109-ont0tqpn	98	9	transporters	transporter	NNS
cord-332109-ont0tqpn	98	10	at	at	IN
cord-332109-ont0tqpn	98	11	the	the	DT
cord-332109-ont0tqpn	98	12	endothelium	endothelium	NN
cord-332109-ont0tqpn	98	13	additionally	additionally	RB
cord-332109-ont0tqpn	98	14	limits	limit	VBZ
cord-332109-ont0tqpn	98	15	molecules	molecule	NNS
cord-332109-ont0tqpn	98	16	from	from	IN
cord-332109-ont0tqpn	98	17	crossing	cross	VBG
cord-332109-ont0tqpn	98	18	the	the	DT
cord-332109-ont0tqpn	98	19	barrier	barrier	NN
cord-332109-ont0tqpn	98	20	[	[	-LRB-
cord-332109-ont0tqpn	98	21	50	50	CD
cord-332109-ont0tqpn	98	22	]	]	-RRB-
cord-332109-ont0tqpn	98	23	[	[	-LRB-
cord-332109-ont0tqpn	98	24	51	51	CD
cord-332109-ont0tqpn	98	25	]	]	-RRB-
cord-332109-ont0tqpn	98	26	[	[	-LRB-
cord-332109-ont0tqpn	98	27	52	52	CD
cord-332109-ont0tqpn	98	28	]	]	-RRB-
cord-332109-ont0tqpn	98	29	.	.	.
cord-332109-ont0tqpn	99	1	The	the	DT
cord-332109-ont0tqpn	99	2	BBB	BBB	NNP
cord-332109-ont0tqpn	99	3	plays	play	VBZ
cord-332109-ont0tqpn	99	4	an	an	DT
cord-332109-ont0tqpn	99	5	essential	essential	JJ
cord-332109-ont0tqpn	99	6	role	role	NN
cord-332109-ont0tqpn	99	7	in	in	IN
cord-332109-ont0tqpn	99	8	protecting	protect	VBG
cord-332109-ont0tqpn	99	9	the	the	DT
cord-332109-ont0tqpn	99	10	brain	brain	NN
cord-332109-ont0tqpn	99	11	from	from	IN
cord-332109-ont0tqpn	99	12	pathogen	pathogen	NN
cord-332109-ont0tqpn	99	13	invasion	invasion	NN
cord-332109-ont0tqpn	99	14	.	.	.
cord-332109-ont0tqpn	100	1	Viral	viral	JJ
cord-332109-ont0tqpn	100	2	infection	infection	NN
cord-332109-ont0tqpn	100	3	of	of	IN
cord-332109-ont0tqpn	100	4	BMVECs	bmvec	NNS
cord-332109-ont0tqpn	100	5	could	could	MD
cord-332109-ont0tqpn	100	6	result	result	VB
cord-332109-ont0tqpn	100	7	in	in	IN
cord-332109-ont0tqpn	100	8	endothelial	endothelial	JJ
cord-332109-ont0tqpn	100	9	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	100	10	,	,	,
cord-332109-ont0tqpn	100	11	leakage	leakage	NN
cord-332109-ont0tqpn	100	12	,	,	,
cord-332109-ont0tqpn	100	13	and	and	CC
cord-332109-ont0tqpn	100	14	even	even	RB
cord-332109-ont0tqpn	100	15	rupture	rupture	NN
cord-332109-ont0tqpn	100	16	,	,	,
cord-332109-ont0tqpn	100	17	and	and	CC
cord-332109-ont0tqpn	100	18	is	be	VBZ
cord-332109-ont0tqpn	100	19	detrimental	detrimental	JJ
cord-332109-ont0tqpn	100	20	to	to	IN
cord-332109-ont0tqpn	100	21	the	the	DT
cord-332109-ont0tqpn	100	22	BBB	BBB	NNP
cord-332109-ont0tqpn	100	23	integrity	integrity	NN
cord-332109-ont0tqpn	100	24	.	.	.
cord-332109-ont0tqpn	101	1	The	the	DT
cord-332109-ont0tqpn	101	2	damaged	damage	VBN
cord-332109-ont0tqpn	101	3	BBB	BBB	NNP
cord-332109-ont0tqpn	101	4	allows	allow	VBZ
cord-332109-ont0tqpn	101	5	the	the	DT
cord-332109-ont0tqpn	101	6	virus	virus	NN
cord-332109-ont0tqpn	101	7	to	to	TO
cord-332109-ont0tqpn	101	8	migrate	migrate	VB
cord-332109-ont0tqpn	101	9	into	into	IN
cord-332109-ont0tqpn	101	10	the	the	DT
cord-332109-ont0tqpn	101	11	brain	brain	NN
cord-332109-ont0tqpn	101	12	side	side	NN
cord-332109-ont0tqpn	101	13	,	,	,
cord-332109-ont0tqpn	101	14	and	and	CC
cord-332109-ont0tqpn	101	15	infect	infect	VB
cord-332109-ont0tqpn	101	16	neuronal	neuronal	JJ
cord-332109-ont0tqpn	101	17	tissues	tissue	NNS
cord-332109-ont0tqpn	101	18	[	[	-LRB-
cord-332109-ont0tqpn	101	19	53	53	CD
cord-332109-ont0tqpn	101	20	]	]	-RRB-
cord-332109-ont0tqpn	101	21	.	.	.
cord-332109-ont0tqpn	102	1	Another	another	DT
cord-332109-ont0tqpn	102	2	possible	possible	JJ
cord-332109-ont0tqpn	102	3	route	route	NN
cord-332109-ont0tqpn	102	4	of	of	IN
cord-332109-ont0tqpn	102	5	CNS	CNS	NNP
cord-332109-ont0tqpn	102	6	invasion	invasion	NN
cord-332109-ont0tqpn	102	7	could	could	MD
cord-332109-ont0tqpn	102	8	be	be	VB
cord-332109-ont0tqpn	102	9	through	through	IN
cord-332109-ont0tqpn	102	10	invading	invade	VBG
cord-332109-ont0tqpn	102	11	the	the	DT
cord-332109-ont0tqpn	102	12	peripheral	peripheral	JJ
cord-332109-ont0tqpn	102	13	nerve	nerve	NN
cord-332109-ont0tqpn	102	14	terminals	terminal	NNS
cord-332109-ont0tqpn	102	15	and	and	CC
cord-332109-ont0tqpn	102	16	then	then	RB
cord-332109-ont0tqpn	102	17	entering	enter	VBG
cord-332109-ont0tqpn	102	18	the	the	DT
cord-332109-ont0tqpn	102	19	CNS	CNS	NNP
cord-332109-ont0tqpn	102	20	via	via	IN
cord-332109-ont0tqpn	102	21	trans	trans	JJ
cord-332109-ont0tqpn	102	22	-	-	JJ
cord-332109-ont0tqpn	102	23	synaptic	synaptic	JJ
cord-332109-ont0tqpn	102	24	transfer	transfer	NN
cord-332109-ont0tqpn	102	25	[	[	-LRB-
cord-332109-ont0tqpn	102	26	54	54	CD
cord-332109-ont0tqpn	102	27	]	]	-RRB-
cord-332109-ont0tqpn	102	28	.	.	.
cord-332109-ont0tqpn	103	1	The	the	DT
cord-332109-ont0tqpn	103	2	first	first	JJ
cord-332109-ont0tqpn	103	3	case	case	NN
cord-332109-ont0tqpn	103	4	of	of	IN
cord-332109-ont0tqpn	103	5	meningitis	meningitis	NN
cord-332109-ont0tqpn	103	6	associated	associate	VBN
cord-332109-ont0tqpn	103	7	with	with	IN
cord-332109-ont0tqpn	103	8	SARS	SARS	NNP
cord-332109-ont0tqpn	103	9	-	-	HYPH
cord-332109-ont0tqpn	103	10	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	103	11	has	have	VBZ
cord-332109-ont0tqpn	103	12	been	be	VBN
cord-332109-ont0tqpn	103	13	reported	report	VBN
cord-332109-ont0tqpn	103	14	,	,	,
cord-332109-ont0tqpn	103	15	in	in	IN
cord-332109-ont0tqpn	103	16	which	which	WDT
cord-332109-ont0tqpn	103	17	viral	viral	JJ
cord-332109-ont0tqpn	103	18	RNA	RNA	NNP
cord-332109-ont0tqpn	103	19	was	be	VBD
cord-332109-ont0tqpn	103	20	detected	detect	VBN
cord-332109-ont0tqpn	103	21	in	in	IN
cord-332109-ont0tqpn	103	22	the	the	DT
cord-332109-ont0tqpn	103	23	cerebrospinal	cerebrospinal	JJ
cord-332109-ont0tqpn	103	24	fluid	fluid	NN
cord-332109-ont0tqpn	103	25	(	(	-LRB-
cord-332109-ont0tqpn	103	26	CSF	CSF	NNP
cord-332109-ont0tqpn	103	27	)	)	-RRB-
cord-332109-ont0tqpn	103	28	of	of	IN
cord-332109-ont0tqpn	103	29	the	the	DT
cord-332109-ont0tqpn	103	30	patient	patient	NN
cord-332109-ont0tqpn	103	31	[	[	-LRB-
cord-332109-ont0tqpn	103	32	55	55	CD
cord-332109-ont0tqpn	103	33	]	]	-RRB-
cord-332109-ont0tqpn	103	34	.	.	.
cord-332109-ont0tqpn	104	1	Clinical	clinical	JJ
cord-332109-ont0tqpn	104	2	evidence	evidence	NN
cord-332109-ont0tqpn	104	3	from	from	IN
cord-332109-ont0tqpn	104	4	Wuhan	Wuhan	NNP
cord-332109-ont0tqpn	104	5	,	,	,
cord-332109-ont0tqpn	104	6	China	China	NNP
cord-332109-ont0tqpn	104	7	showed	show	VBD
cord-332109-ont0tqpn	104	8	that	that	IN
cord-332109-ont0tqpn	104	9	more	more	JJR
cord-332109-ont0tqpn	104	10	than	than	IN
cord-332109-ont0tqpn	104	11	1/3	1/3	CD
cord-332109-ont0tqpn	104	12	of	of	IN
cord-332109-ont0tqpn	104	13	COVID-19	covid-19	CD
cord-332109-ont0tqpn	104	14	patients	patient	NNS
cord-332109-ont0tqpn	104	15	had	have	VBD
cord-332109-ont0tqpn	104	16	neurological	neurological	JJ
cord-332109-ont0tqpn	104	17	symptoms	symptom	NNS
cord-332109-ont0tqpn	104	18	,	,	,
cord-332109-ont0tqpn	104	19	and	and	CC
cord-332109-ont0tqpn	104	20	CNS	CNS	NNP
cord-332109-ont0tqpn	104	21	involvement	involvement	NN
cord-332109-ont0tqpn	104	22	was	be	VBD
cord-332109-ont0tqpn	104	23	linked	link	VBN
cord-332109-ont0tqpn	104	24	to	to	IN
cord-332109-ont0tqpn	104	25	the	the	DT
cord-332109-ont0tqpn	104	26	prognosis	prognosis	NN
cord-332109-ont0tqpn	104	27	and	and	CC
cord-332109-ont0tqpn	104	28	severity	severity	NN
cord-332109-ont0tqpn	104	29	of	of	IN
cord-332109-ont0tqpn	104	30	the	the	DT
cord-332109-ont0tqpn	104	31	disease	disease	NN
cord-332109-ont0tqpn	104	32	[	[	-LRB-
cord-332109-ont0tqpn	104	33	56	56	CD
cord-332109-ont0tqpn	104	34	,	,	,
cord-332109-ont0tqpn	104	35	57	57	CD
cord-332109-ont0tqpn	104	36	]	]	-RRB-
cord-332109-ont0tqpn	104	37	.	.	.
cord-332109-ont0tqpn	105	1	Substances	substance	NNS
cord-332109-ont0tqpn	105	2	of	of	IN
cord-332109-ont0tqpn	105	3	abuse	abuse	NN
cord-332109-ont0tqpn	105	4	have	have	VBP
cord-332109-ont0tqpn	105	5	been	be	VBN
cord-332109-ont0tqpn	105	6	shown	show	VBN
cord-332109-ont0tqpn	105	7	to	to	IN
cord-332109-ont0tqpn	105	8	severely	severely	RB
cord-332109-ont0tqpn	105	9	compromise	compromise	VB
cord-332109-ont0tqpn	105	10	the	the	DT
cord-332109-ont0tqpn	105	11	endothelial	endothelial	JJ
cord-332109-ont0tqpn	105	12	barrier	barrier	NN
cord-332109-ont0tqpn	105	13	at	at	IN
cord-332109-ont0tqpn	105	14	the	the	DT
cord-332109-ont0tqpn	105	15	BBB	BBB	NNP
cord-332109-ont0tqpn	105	16	,	,	,
cord-332109-ont0tqpn	105	17	leading	lead	VBG
cord-332109-ont0tqpn	105	18	to	to	IN
cord-332109-ont0tqpn	105	19	increased	increase	VBN
cord-332109-ont0tqpn	105	20	BBB	BBB	NNP
cord-332109-ont0tqpn	105	21	permeability	permeability	NN
cord-332109-ont0tqpn	105	22	and	and	CC
cord-332109-ont0tqpn	105	23	possibly	possibly	RB
cord-332109-ont0tqpn	105	24	intensified	intensify	VBD
cord-332109-ont0tqpn	105	25	brain	brain	NN
cord-332109-ont0tqpn	105	26	damage	damage	NN
cord-332109-ont0tqpn	105	27	in	in	IN
cord-332109-ont0tqpn	105	28	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	105	29	(	(	-LRB-
cord-332109-ont0tqpn	105	30	Figure	figure	NN
cord-332109-ont0tqpn	105	31	2	2	CD
cord-332109-ont0tqpn	105	32	)	)	-RRB-
cord-332109-ont0tqpn	105	33	.	.	.
cord-332109-ont0tqpn	106	1	Pharmaceuticals	pharmaceutical	NNS
cord-332109-ont0tqpn	106	2	2020	2020	CD
cord-332109-ont0tqpn	106	3	,	,	,
cord-332109-ont0tqpn	106	4	13	13	CD
cord-332109-ont0tqpn	106	5	,	,	,
cord-332109-ont0tqpn	106	6	x	x	NN
cord-332109-ont0tqpn	106	7	FOR	for	IN
cord-332109-ont0tqpn	106	8	PEER	PEER	NNP
cord-332109-ont0tqpn	106	9	REVIEW	REVIEW	NNP
cord-332109-ont0tqpn	106	10	6	6	CD
cord-332109-ont0tqpn	106	11	of	of	IN
cord-332109-ont0tqpn	106	12	29	29	CD
cord-332109-ont0tqpn	106	13	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	106	14	,	,	,
cord-332109-ont0tqpn	106	15	leakage	leakage	NN
cord-332109-ont0tqpn	106	16	,	,	,
cord-332109-ont0tqpn	106	17	and	and	CC
cord-332109-ont0tqpn	106	18	even	even	RB
cord-332109-ont0tqpn	106	19	rupture	rupture	NN
cord-332109-ont0tqpn	106	20	,	,	,
cord-332109-ont0tqpn	106	21	and	and	CC
cord-332109-ont0tqpn	106	22	is	be	VBZ
cord-332109-ont0tqpn	106	23	detrimental	detrimental	JJ
cord-332109-ont0tqpn	106	24	to	to	IN
cord-332109-ont0tqpn	106	25	the	the	DT
cord-332109-ont0tqpn	106	26	BBB	BBB	NNP
cord-332109-ont0tqpn	106	27	integrity	integrity	NN
cord-332109-ont0tqpn	106	28	.	.	.
cord-332109-ont0tqpn	107	1	The	the	DT
cord-332109-ont0tqpn	107	2	damaged	damage	VBN
cord-332109-ont0tqpn	107	3	BBB	BBB	NNP
cord-332109-ont0tqpn	107	4	allows	allow	VBZ
cord-332109-ont0tqpn	107	5	the	the	DT
cord-332109-ont0tqpn	107	6	virus	virus	NN
cord-332109-ont0tqpn	107	7	to	to	TO
cord-332109-ont0tqpn	107	8	migrate	migrate	VB
cord-332109-ont0tqpn	107	9	into	into	IN
cord-332109-ont0tqpn	107	10	the	the	DT
cord-332109-ont0tqpn	107	11	brain	brain	NN
cord-332109-ont0tqpn	107	12	side	side	NN
cord-332109-ont0tqpn	107	13	,	,	,
cord-332109-ont0tqpn	107	14	and	and	CC
cord-332109-ont0tqpn	107	15	infect	infect	VB
cord-332109-ont0tqpn	107	16	neuronal	neuronal	JJ
cord-332109-ont0tqpn	107	17	tissues	tissue	NNS
cord-332109-ont0tqpn	107	18	[	[	-LRB-
cord-332109-ont0tqpn	107	19	53	53	CD
cord-332109-ont0tqpn	107	20	]	]	-RRB-
cord-332109-ont0tqpn	107	21	.	.	.
cord-332109-ont0tqpn	108	1	Another	another	DT
cord-332109-ont0tqpn	108	2	possible	possible	JJ
cord-332109-ont0tqpn	108	3	route	route	NN
cord-332109-ont0tqpn	108	4	of	of	IN
cord-332109-ont0tqpn	108	5	CNS	CNS	NNP
cord-332109-ont0tqpn	108	6	invasion	invasion	NN
cord-332109-ont0tqpn	108	7	could	could	MD
cord-332109-ont0tqpn	108	8	be	be	VB
cord-332109-ont0tqpn	108	9	through	through	IN
cord-332109-ont0tqpn	108	10	invading	invade	VBG
cord-332109-ont0tqpn	108	11	the	the	DT
cord-332109-ont0tqpn	108	12	peripheral	peripheral	JJ
cord-332109-ont0tqpn	108	13	nerve	nerve	NN
cord-332109-ont0tqpn	108	14	terminals	terminal	NNS
cord-332109-ont0tqpn	108	15	and	and	CC
cord-332109-ont0tqpn	108	16	then	then	RB
cord-332109-ont0tqpn	108	17	entering	enter	VBG
cord-332109-ont0tqpn	108	18	the	the	DT
cord-332109-ont0tqpn	108	19	CNS	CNS	NNP
cord-332109-ont0tqpn	108	20	via	via	IN
cord-332109-ont0tqpn	108	21	trans	trans	JJ
cord-332109-ont0tqpn	108	22	-	-	JJ
cord-332109-ont0tqpn	108	23	synaptic	synaptic	JJ
cord-332109-ont0tqpn	108	24	transfer	transfer	NN
cord-332109-ont0tqpn	108	25	[	[	-LRB-
cord-332109-ont0tqpn	108	26	54	54	CD
cord-332109-ont0tqpn	108	27	]	]	-RRB-
cord-332109-ont0tqpn	108	28	.	.	.
cord-332109-ont0tqpn	109	1	The	the	DT
cord-332109-ont0tqpn	109	2	first	first	JJ
cord-332109-ont0tqpn	109	3	case	case	NN
cord-332109-ont0tqpn	109	4	of	of	IN
cord-332109-ont0tqpn	109	5	meningitis	meningitis	NN
cord-332109-ont0tqpn	109	6	associated	associate	VBN
cord-332109-ont0tqpn	109	7	with	with	IN
cord-332109-ont0tqpn	109	8	SARS	SARS	NNP
cord-332109-ont0tqpn	109	9	-	-	HYPH
cord-332109-ont0tqpn	109	10	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	109	11	has	have	VBZ
cord-332109-ont0tqpn	109	12	been	be	VBN
cord-332109-ont0tqpn	109	13	reported	report	VBN
cord-332109-ont0tqpn	109	14	,	,	,
cord-332109-ont0tqpn	109	15	in	in	IN
cord-332109-ont0tqpn	109	16	which	which	WDT
cord-332109-ont0tqpn	109	17	viral	viral	JJ
cord-332109-ont0tqpn	109	18	RNA	RNA	NNP
cord-332109-ont0tqpn	109	19	was	be	VBD
cord-332109-ont0tqpn	109	20	detected	detect	VBN
cord-332109-ont0tqpn	109	21	in	in	IN
cord-332109-ont0tqpn	109	22	the	the	DT
cord-332109-ont0tqpn	109	23	cerebrospinal	cerebrospinal	JJ
cord-332109-ont0tqpn	109	24	fluid	fluid	NN
cord-332109-ont0tqpn	109	25	(	(	-LRB-
cord-332109-ont0tqpn	109	26	CSF	CSF	NNP
cord-332109-ont0tqpn	109	27	)	)	-RRB-
cord-332109-ont0tqpn	109	28	of	of	IN
cord-332109-ont0tqpn	109	29	the	the	DT
cord-332109-ont0tqpn	109	30	patient	patient	NN
cord-332109-ont0tqpn	109	31	[	[	-LRB-
cord-332109-ont0tqpn	109	32	55	55	CD
cord-332109-ont0tqpn	109	33	]	]	-RRB-
cord-332109-ont0tqpn	109	34	.	.	.
cord-332109-ont0tqpn	110	1	Clinical	clinical	JJ
cord-332109-ont0tqpn	110	2	evidence	evidence	NN
cord-332109-ont0tqpn	110	3	from	from	IN
cord-332109-ont0tqpn	110	4	Wuhan	Wuhan	NNP
cord-332109-ont0tqpn	110	5	,	,	,
cord-332109-ont0tqpn	110	6	China	China	NNP
cord-332109-ont0tqpn	110	7	showed	show	VBD
cord-332109-ont0tqpn	110	8	that	that	IN
cord-332109-ont0tqpn	110	9	more	more	JJR
cord-332109-ont0tqpn	110	10	than	than	IN
cord-332109-ont0tqpn	110	11	1/3	1/3	CD
cord-332109-ont0tqpn	110	12	of	of	IN
cord-332109-ont0tqpn	110	13	COVID-19	covid-19	CD
cord-332109-ont0tqpn	110	14	patients	patient	NNS
cord-332109-ont0tqpn	110	15	had	have	VBD
cord-332109-ont0tqpn	110	16	neurological	neurological	JJ
cord-332109-ont0tqpn	110	17	symptoms	symptom	NNS
cord-332109-ont0tqpn	110	18	,	,	,
cord-332109-ont0tqpn	110	19	and	and	CC
cord-332109-ont0tqpn	110	20	CNS	CNS	NNP
cord-332109-ont0tqpn	110	21	involvement	involvement	NN
cord-332109-ont0tqpn	110	22	was	be	VBD
cord-332109-ont0tqpn	110	23	linked	link	VBN
cord-332109-ont0tqpn	110	24	to	to	IN
cord-332109-ont0tqpn	110	25	the	the	DT
cord-332109-ont0tqpn	110	26	prognosis	prognosis	NN
cord-332109-ont0tqpn	110	27	and	and	CC
cord-332109-ont0tqpn	110	28	severity	severity	NN
cord-332109-ont0tqpn	110	29	of	of	IN
cord-332109-ont0tqpn	110	30	the	the	DT
cord-332109-ont0tqpn	110	31	disease	disease	NN
cord-332109-ont0tqpn	110	32	[	[	-LRB-
cord-332109-ont0tqpn	110	33	56	56	CD
cord-332109-ont0tqpn	110	34	,	,	,
cord-332109-ont0tqpn	110	35	57	57	CD
cord-332109-ont0tqpn	110	36	]	]	-RRB-
cord-332109-ont0tqpn	110	37	.	.	.
cord-332109-ont0tqpn	111	1	Substances	substance	NNS
cord-332109-ont0tqpn	111	2	of	of	IN
cord-332109-ont0tqpn	111	3	abuse	abuse	NN
cord-332109-ont0tqpn	111	4	have	have	VBP
cord-332109-ont0tqpn	111	5	been	be	VBN
cord-332109-ont0tqpn	111	6	shown	show	VBN
cord-332109-ont0tqpn	111	7	to	to	IN
cord-332109-ont0tqpn	111	8	severely	severely	RB
cord-332109-ont0tqpn	111	9	compromise	compromise	VB
cord-332109-ont0tqpn	111	10	the	the	DT
cord-332109-ont0tqpn	111	11	endothelial	endothelial	JJ
cord-332109-ont0tqpn	111	12	barrier	barrier	NN
cord-332109-ont0tqpn	111	13	at	at	IN
cord-332109-ont0tqpn	111	14	the	the	DT
cord-332109-ont0tqpn	111	15	BBB	BBB	NNP
cord-332109-ont0tqpn	111	16	,	,	,
cord-332109-ont0tqpn	111	17	leading	lead	VBG
cord-332109-ont0tqpn	111	18	to	to	IN
cord-332109-ont0tqpn	111	19	increased	increase	VBN
cord-332109-ont0tqpn	111	20	BBB	BBB	NNP
cord-332109-ont0tqpn	111	21	permeability	permeability	NN
cord-332109-ont0tqpn	111	22	and	and	CC
cord-332109-ont0tqpn	111	23	possibly	possibly	RB
cord-332109-ont0tqpn	111	24	intensified	intensify	VBD
cord-332109-ont0tqpn	111	25	brain	brain	NN
cord-332109-ont0tqpn	111	26	damage	damage	NN
cord-332109-ont0tqpn	111	27	in	in	IN
cord-332109-ont0tqpn	111	28	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	111	29	(	(	-LRB-
cord-332109-ont0tqpn	111	30	Figure	figure	NN
cord-332109-ont0tqpn	111	31	2	2	CD
cord-332109-ont0tqpn	111	32	)	)	-RRB-
cord-332109-ont0tqpn	111	33	.	.	.
cord-332109-ont0tqpn	112	1	The	the	DT
cord-332109-ont0tqpn	112	2	other	other	JJ
cord-332109-ont0tqpn	112	3	aspect	aspect	NN
cord-332109-ont0tqpn	112	4	of	of	IN
cord-332109-ont0tqpn	112	5	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	112	6	pathology	pathology	NN
cord-332109-ont0tqpn	112	7	involves	involve	VBZ
cord-332109-ont0tqpn	112	8	abnormal	abnormal	JJ
cord-332109-ont0tqpn	112	9	immune	immune	JJ
cord-332109-ont0tqpn	112	10	responses	response	NNS
cord-332109-ont0tqpn	112	11	,	,	,
cord-332109-ont0tqpn	112	12	which	which	WDT
cord-332109-ont0tqpn	112	13	could	could	MD
cord-332109-ont0tqpn	112	14	exaggerate	exaggerate	VB
cord-332109-ont0tqpn	112	15	into	into	IN
cord-332109-ont0tqpn	112	16	a	a	DT
cord-332109-ont0tqpn	112	17	cytokine	cytokine	NN
cord-332109-ont0tqpn	112	18	storm	storm	NN
cord-332109-ont0tqpn	112	19	[	[	-LRB-
cord-332109-ont0tqpn	112	20	58	58	CD
cord-332109-ont0tqpn	112	21	,	,	,
cord-332109-ont0tqpn	112	22	59	59	CD
cord-332109-ont0tqpn	112	23	]	]	-RRB-
cord-332109-ont0tqpn	112	24	.	.	.
cord-332109-ont0tqpn	113	1	SARS	SARS	NNP
cord-332109-ont0tqpn	113	2	-	-	HYPH
cord-332109-ont0tqpn	113	3	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	113	4	dramatically	dramatically	RB
cord-332109-ont0tqpn	113	5	promotes	promote	VBZ
cord-332109-ont0tqpn	113	6	host	host	NN
cord-332109-ont0tqpn	113	7	cell	cell	NN
cord-332109-ont0tqpn	113	8	kinase	kinase	NN
cord-332109-ont0tqpn	113	9	activities	activity	NNS
cord-332109-ont0tqpn	113	10	,	,	,
cord-332109-ont0tqpn	113	11	including	include	VBG
cord-332109-ont0tqpn	113	12	casein	casein	NN
cord-332109-ont0tqpn	113	13	kinase	kinase	NNP
cord-332109-ont0tqpn	113	14	II	II	NNP
cord-332109-ont0tqpn	113	15	(	(	-LRB-
cord-332109-ont0tqpn	113	16	CK2	CK2	NNP
cord-332109-ont0tqpn	113	17	)	)	-RRB-
cord-332109-ont0tqpn	113	18	and	and	CC
cord-332109-ont0tqpn	113	19	p38	p38	CD
cord-332109-ont0tqpn	113	20	,	,	,
cord-332109-ont0tqpn	113	21	and	and	CC
cord-332109-ont0tqpn	113	22	stimulates	stimulate	VBZ
cord-332109-ont0tqpn	113	23	production	production	NN
cord-332109-ont0tqpn	113	24	of	of	IN
cord-332109-ont0tqpn	113	25	diverse	diverse	JJ
cord-332109-ont0tqpn	113	26	cytokines	cytokine	NNS
cord-332109-ont0tqpn	113	27	[	[	-LRB-
cord-332109-ont0tqpn	113	28	60	60	CD
cord-332109-ont0tqpn	113	29	]	]	-RRB-
cord-332109-ont0tqpn	113	30	.	.	.
cord-332109-ont0tqpn	114	1	Evidence	evidence	NN
cord-332109-ont0tqpn	114	2	has	have	VBZ
cord-332109-ont0tqpn	114	3	shown	show	VBN
cord-332109-ont0tqpn	114	4	that	that	IN
cord-332109-ont0tqpn	114	5	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	114	6	elevates	elevate	VBZ
cord-332109-ont0tqpn	114	7	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	114	8	cytokines	cytokine	NNS
cord-332109-ont0tqpn	114	9	and	and	CC
cord-332109-ont0tqpn	114	10	chemokines	chemokine	NNS
cord-332109-ont0tqpn	114	11	,	,	,
cord-332109-ont0tqpn	114	12	including	include	VBG
cord-332109-ont0tqpn	114	13	tumor	tumor	NN
cord-332109-ont0tqpn	114	14	necrosis	necrosis	NN
cord-332109-ont0tqpn	114	15	factor	factor	NN
cord-332109-ont0tqpn	114	16	(	(	-LRB-
cord-332109-ont0tqpn	114	17	TNF)-α	tnf)-α	NN
cord-332109-ont0tqpn	114	18	,	,	,
cord-332109-ont0tqpn	114	19	interleukin	interleukin	FW
cord-332109-ont0tqpn	114	20	(	(	-LRB-
cord-332109-ont0tqpn	114	21	IL)-1β	IL)-1β	NNP
cord-332109-ont0tqpn	114	22	and	and	CC
cord-332109-ont0tqpn	114	23	IL-6	IL-6	NNP
cord-332109-ont0tqpn	114	24	,	,	,
cord-332109-ont0tqpn	114	25	granulocyte	granulocyte	NN
cord-332109-ont0tqpn	114	26	-	-	HYPH
cord-332109-ont0tqpn	114	27	colony	colony	NN
cord-332109-ont0tqpn	114	28	stimulating	stimulating	NN
cord-332109-ont0tqpn	114	29	factor	factor	NN
cord-332109-ont0tqpn	114	30	(	(	-LRB-
cord-332109-ont0tqpn	114	31	G	G	NNP
cord-332109-ont0tqpn	114	32	-	-	HYPH
cord-332109-ont0tqpn	114	33	CSF	CSF	NNP
cord-332109-ont0tqpn	114	34	)	)	-RRB-
cord-332109-ont0tqpn	114	35	,	,	,
cord-332109-ont0tqpn	114	36	interferon	interferon	NN
cord-332109-ont0tqpn	114	37	γ	γ	NN
cord-332109-ont0tqpn	114	38	(	(	-LRB-
cord-332109-ont0tqpn	114	39	IFN	IFN	NNP
cord-332109-ont0tqpn	114	40	-	-	HYPH
cord-332109-ont0tqpn	114	41	γ)-induced	γ)-induced	NNP
cord-332109-ont0tqpn	114	42	protein-10	protein-10	NN
cord-332109-ont0tqpn	114	43	(	(	-LRB-
cord-332109-ont0tqpn	114	44	IP-10	IP-10	NNP
cord-332109-ont0tqpn	114	45	)	)	-RRB-
cord-332109-ont0tqpn	114	46	,	,	,
cord-332109-ont0tqpn	114	47	monocyte	monocyte	NNP
cord-332109-ont0tqpn	114	48	chemoattractant	chemoattractant	NNP
cord-332109-ont0tqpn	114	49	protein-1	protein-1	NNP
cord-332109-ont0tqpn	114	50	(	(	-LRB-
cord-332109-ont0tqpn	114	51	MCP-1	MCP-1	NNP
cord-332109-ont0tqpn	114	52	)	)	-RRB-
cord-332109-ont0tqpn	114	53	,	,	,
cord-332109-ont0tqpn	114	54	and	and	CC
cord-332109-ont0tqpn	114	55	macrophage	macrophage	NN
cord-332109-ont0tqpn	114	56	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	114	57	proteins-1α	proteins-1α	NN
cord-332109-ont0tqpn	114	58	(	(	-LRB-
cord-332109-ont0tqpn	114	59	MIP-1α	MIP-1α	NNP
cord-332109-ont0tqpn	114	60	)	)	-RRB-
cord-332109-ont0tqpn	114	61	[	[	-LRB-
cord-332109-ont0tqpn	114	62	61	61	CD
cord-332109-ont0tqpn	114	63	]	]	-RRB-
cord-332109-ont0tqpn	114	64	[	[	-LRB-
cord-332109-ont0tqpn	114	65	62	62	CD
cord-332109-ont0tqpn	114	66	]	]	-RRB-
cord-332109-ont0tqpn	114	67	[	[	-LRB-
cord-332109-ont0tqpn	114	68	63	63	CD
cord-332109-ont0tqpn	114	69	]	]	-RRB-
cord-332109-ont0tqpn	114	70	.	.	.
cord-332109-ont0tqpn	115	1	Although	although	IN
cord-332109-ont0tqpn	115	2	there	there	EX
cord-332109-ont0tqpn	115	3	has	have	VBZ
cord-332109-ont0tqpn	115	4	been	be	VBN
cord-332109-ont0tqpn	115	5	no	no	DT
cord-332109-ont0tqpn	115	6	reported	report	VBN
cord-332109-ont0tqpn	115	7	evidence	evidence	NN
cord-332109-ont0tqpn	115	8	,	,	,
cord-332109-ont0tqpn	115	9	it	-PRON-	PRP
cord-332109-ont0tqpn	115	10	is	be	VBZ
cord-332109-ont0tqpn	115	11	possible	possible	JJ
cord-332109-ont0tqpn	115	12	that	that	IN
cord-332109-ont0tqpn	115	13	pattern	pattern	NN
cord-332109-ont0tqpn	115	14	recognition	recognition	NN
cord-332109-ont0tqpn	115	15	receptors	receptor	NNS
cord-332109-ont0tqpn	115	16	,	,	,
cord-332109-ont0tqpn	115	17	such	such	JJ
cord-332109-ont0tqpn	115	18	as	as	IN
cord-332109-ont0tqpn	115	19	toll	toll	NN
cord-332109-ont0tqpn	115	20	-	-	HYPH
cord-332109-ont0tqpn	115	21	like	like	JJ
cord-332109-ont0tqpn	115	22	receptors	receptor	NNS
cord-332109-ont0tqpn	115	23	(	(	-LRB-
cord-332109-ont0tqpn	115	24	TLR3	TLR3	NNP
cord-332109-ont0tqpn	115	25	,	,	,
cord-332109-ont0tqpn	115	26	TLR7	TLR7	NNP
cord-332109-ont0tqpn	115	27	,	,	,
cord-332109-ont0tqpn	115	28	and	and	CC
cord-332109-ont0tqpn	115	29	TLR8	TLR8	NNP
cord-332109-ont0tqpn	115	30	)	)	-RRB-
cord-332109-ont0tqpn	115	31	,	,	,
cord-332109-ont0tqpn	115	32	RIG	rig	NN
cord-332109-ont0tqpn	115	33	-	-	:
cord-332109-ont0tqpn	115	34	I	I	NNP
cord-332109-ont0tqpn	115	35	,	,	,
cord-332109-ont0tqpn	115	36	and	and	CC
cord-332109-ont0tqpn	115	37	nucleotide	nucleotide	NN
cord-332109-ont0tqpn	115	38	-	-	HYPH
cord-332109-ont0tqpn	115	39	binding	bind	VBG
cord-332109-ont0tqpn	115	40	oligomerization	oligomerization	NN
cord-332109-ont0tqpn	115	41	domain	domain	NN
cord-332109-ont0tqpn	115	42	(	(	-LRB-
cord-332109-ont0tqpn	115	43	NOD)-like	nod)-like	CD
cord-332109-ont0tqpn	115	44	receptors	receptor	NNS
cord-332109-ont0tqpn	115	45	(	(	-LRB-
cord-332109-ont0tqpn	116	1	NLRP1	NLRP1	NNP
cord-332109-ont0tqpn	116	2	,	,	,
cord-332109-ont0tqpn	116	3	NLRP3	nlrp3	XX
cord-332109-ont0tqpn	116	4	,	,	,
cord-332109-ont0tqpn	116	5	and	and	CC
cord-332109-ont0tqpn	116	6	NLRP12	NLRP12	NNP
cord-332109-ont0tqpn	116	7	)	)	-RRB-
cord-332109-ont0tqpn	116	8	,	,	,
cord-332109-ont0tqpn	116	9	are	be	VBP
cord-332109-ont0tqpn	116	10	also	also	RB
cord-332109-ont0tqpn	116	11	activated	activate	VBN
cord-332109-ont0tqpn	116	12	by	by	IN
cord-332109-ont0tqpn	116	13	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	116	14	through	through	IN
cord-332109-ont0tqpn	116	15	innate	innate	JJ
cord-332109-ont0tqpn	116	16	immunity	immunity	NN
cord-332109-ont0tqpn	116	17	[	[	-LRB-
cord-332109-ont0tqpn	116	18	64	64	CD
cord-332109-ont0tqpn	116	19	]	]	-RRB-
cord-332109-ont0tqpn	116	20	.	.	.
cord-332109-ont0tqpn	117	1	It	-PRON-	PRP
cord-332109-ont0tqpn	117	2	has	have	VBZ
cord-332109-ont0tqpn	117	3	been	be	VBN
cord-332109-ont0tqpn	117	4	reported	report	VBN
cord-332109-ont0tqpn	117	5	that	that	IN
cord-332109-ont0tqpn	117	6	IL-6	IL-6	NNP
cord-332109-ont0tqpn	117	7	was	be	VBD
cord-332109-ont0tqpn	117	8	significantly	significantly	RB
cord-332109-ont0tqpn	117	9	increased	increase	VBN
cord-332109-ont0tqpn	117	10	in	in	IN
cord-332109-ont0tqpn	117	11	severe	severe	JJ
cord-332109-ont0tqpn	117	12	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	117	13	cases	case	NNS
cord-332109-ont0tqpn	117	14	,	,	,
cord-332109-ont0tqpn	117	15	and	and	CC
cord-332109-ont0tqpn	117	16	its	-PRON-	PRP$
cord-332109-ont0tqpn	117	17	level	level	NN
cord-332109-ont0tqpn	117	18	was	be	VBD
cord-332109-ont0tqpn	117	19	closely	closely	RB
cord-332109-ont0tqpn	117	20	correlated	correlate	VBN
cord-332109-ont0tqpn	117	21	with	with	IN
cord-332109-ont0tqpn	117	22	the	the	DT
cord-332109-ont0tqpn	117	23	severity	severity	NN
cord-332109-ont0tqpn	117	24	of	of	IN
cord-332109-ont0tqpn	117	25	patients	patient	NNS
cord-332109-ont0tqpn	117	26	[	[	-LRB-
cord-332109-ont0tqpn	117	27	65	65	CD
cord-332109-ont0tqpn	117	28	]	]	-RRB-
cord-332109-ont0tqpn	117	29	.	.	.
cord-332109-ont0tqpn	118	1	Human	human	JJ
cord-332109-ont0tqpn	118	2	bronchial	bronchial	JJ
cord-332109-ont0tqpn	118	3	epithelial	epithelial	JJ
cord-332109-ont0tqpn	118	4	cells	cell	NNS
cord-332109-ont0tqpn	118	5	infected	infect	VBN
cord-332109-ont0tqpn	118	6	with	with	IN
cord-332109-ont0tqpn	118	7	SARS-	SARS-	NNP
cord-332109-ont0tqpn	119	1	The	the	DT
cord-332109-ont0tqpn	119	2	other	other	JJ
cord-332109-ont0tqpn	119	3	aspect	aspect	NN
cord-332109-ont0tqpn	119	4	of	of	IN
cord-332109-ont0tqpn	119	5	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	119	6	pathology	pathology	NN
cord-332109-ont0tqpn	119	7	involves	involve	VBZ
cord-332109-ont0tqpn	119	8	abnormal	abnormal	JJ
cord-332109-ont0tqpn	119	9	immune	immune	JJ
cord-332109-ont0tqpn	119	10	responses	response	NNS
cord-332109-ont0tqpn	119	11	,	,	,
cord-332109-ont0tqpn	119	12	which	which	WDT
cord-332109-ont0tqpn	119	13	could	could	MD
cord-332109-ont0tqpn	119	14	exaggerate	exaggerate	VB
cord-332109-ont0tqpn	119	15	into	into	IN
cord-332109-ont0tqpn	119	16	a	a	DT
cord-332109-ont0tqpn	119	17	cytokine	cytokine	NN
cord-332109-ont0tqpn	119	18	storm	storm	NN
cord-332109-ont0tqpn	119	19	[	[	-LRB-
cord-332109-ont0tqpn	119	20	58	58	CD
cord-332109-ont0tqpn	119	21	,	,	,
cord-332109-ont0tqpn	119	22	59	59	CD
cord-332109-ont0tqpn	119	23	]	]	-RRB-
cord-332109-ont0tqpn	119	24	.	.	.
cord-332109-ont0tqpn	120	1	SARS	SARS	NNP
cord-332109-ont0tqpn	120	2	-	-	HYPH
cord-332109-ont0tqpn	120	3	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	120	4	dramatically	dramatically	RB
cord-332109-ont0tqpn	120	5	promotes	promote	VBZ
cord-332109-ont0tqpn	120	6	host	host	NN
cord-332109-ont0tqpn	120	7	cell	cell	NN
cord-332109-ont0tqpn	120	8	kinase	kinase	NN
cord-332109-ont0tqpn	120	9	activities	activity	NNS
cord-332109-ont0tqpn	120	10	,	,	,
cord-332109-ont0tqpn	120	11	including	include	VBG
cord-332109-ont0tqpn	120	12	casein	casein	NN
cord-332109-ont0tqpn	120	13	kinase	kinase	NNP
cord-332109-ont0tqpn	120	14	II	II	NNP
cord-332109-ont0tqpn	120	15	(	(	-LRB-
cord-332109-ont0tqpn	120	16	CK2	CK2	NNP
cord-332109-ont0tqpn	120	17	)	)	-RRB-
cord-332109-ont0tqpn	120	18	and	and	CC
cord-332109-ont0tqpn	120	19	p38	p38	CD
cord-332109-ont0tqpn	120	20	,	,	,
cord-332109-ont0tqpn	120	21	and	and	CC
cord-332109-ont0tqpn	120	22	stimulates	stimulate	VBZ
cord-332109-ont0tqpn	120	23	production	production	NN
cord-332109-ont0tqpn	120	24	of	of	IN
cord-332109-ont0tqpn	120	25	diverse	diverse	JJ
cord-332109-ont0tqpn	120	26	cytokines	cytokine	NNS
cord-332109-ont0tqpn	120	27	[	[	-LRB-
cord-332109-ont0tqpn	120	28	60	60	CD
cord-332109-ont0tqpn	120	29	]	]	-RRB-
cord-332109-ont0tqpn	120	30	.	.	.
cord-332109-ont0tqpn	121	1	Evidence	evidence	NN
cord-332109-ont0tqpn	121	2	has	have	VBZ
cord-332109-ont0tqpn	121	3	shown	show	VBN
cord-332109-ont0tqpn	121	4	that	that	IN
cord-332109-ont0tqpn	121	5	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	121	6	elevates	elevate	VBZ
cord-332109-ont0tqpn	121	7	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	121	8	cytokines	cytokine	NNS
cord-332109-ont0tqpn	121	9	and	and	CC
cord-332109-ont0tqpn	121	10	chemokines	chemokine	NNS
cord-332109-ont0tqpn	121	11	,	,	,
cord-332109-ont0tqpn	121	12	including	include	VBG
cord-332109-ont0tqpn	121	13	tumor	tumor	NN
cord-332109-ont0tqpn	121	14	necrosis	necrosis	NN
cord-332109-ont0tqpn	121	15	factor	factor	NN
cord-332109-ont0tqpn	121	16	(	(	-LRB-
cord-332109-ont0tqpn	121	17	TNF)-α	tnf)-α	NN
cord-332109-ont0tqpn	121	18	,	,	,
cord-332109-ont0tqpn	121	19	interleukin	interleukin	FW
cord-332109-ont0tqpn	121	20	(	(	-LRB-
cord-332109-ont0tqpn	121	21	IL)-1β	IL)-1β	NNP
cord-332109-ont0tqpn	121	22	and	and	CC
cord-332109-ont0tqpn	121	23	IL-6	IL-6	NNP
cord-332109-ont0tqpn	121	24	,	,	,
cord-332109-ont0tqpn	121	25	granulocyte	granulocyte	NN
cord-332109-ont0tqpn	121	26	-	-	HYPH
cord-332109-ont0tqpn	121	27	colony	colony	NN
cord-332109-ont0tqpn	121	28	stimulating	stimulating	NN
cord-332109-ont0tqpn	121	29	factor	factor	NN
cord-332109-ont0tqpn	121	30	(	(	-LRB-
cord-332109-ont0tqpn	121	31	G	G	NNP
cord-332109-ont0tqpn	121	32	-	-	HYPH
cord-332109-ont0tqpn	121	33	CSF	CSF	NNP
cord-332109-ont0tqpn	121	34	)	)	-RRB-
cord-332109-ont0tqpn	121	35	,	,	,
cord-332109-ont0tqpn	121	36	interferon	interferon	NN
cord-332109-ont0tqpn	121	37	γ	γ	NN
cord-332109-ont0tqpn	121	38	(	(	-LRB-
cord-332109-ont0tqpn	121	39	IFN	IFN	NNP
cord-332109-ont0tqpn	121	40	-	-	HYPH
cord-332109-ont0tqpn	121	41	γ)-induced	γ)-induced	NNP
cord-332109-ont0tqpn	121	42	protein-10	protein-10	NN
cord-332109-ont0tqpn	121	43	(	(	-LRB-
cord-332109-ont0tqpn	121	44	IP-10	IP-10	NNP
cord-332109-ont0tqpn	121	45	)	)	-RRB-
cord-332109-ont0tqpn	121	46	,	,	,
cord-332109-ont0tqpn	121	47	monocyte	monocyte	NNP
cord-332109-ont0tqpn	121	48	chemoattractant	chemoattractant	NNP
cord-332109-ont0tqpn	121	49	protein-1	protein-1	NNP
cord-332109-ont0tqpn	121	50	(	(	-LRB-
cord-332109-ont0tqpn	121	51	MCP-1	MCP-1	NNP
cord-332109-ont0tqpn	121	52	)	)	-RRB-
cord-332109-ont0tqpn	121	53	,	,	,
cord-332109-ont0tqpn	121	54	and	and	CC
cord-332109-ont0tqpn	121	55	macrophage	macrophage	NN
cord-332109-ont0tqpn	121	56	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	121	57	proteins-1α	proteins-1α	NN
cord-332109-ont0tqpn	121	58	(	(	-LRB-
cord-332109-ont0tqpn	121	59	MIP-1α	MIP-1α	NNP
cord-332109-ont0tqpn	121	60	)	)	-RRB-
cord-332109-ont0tqpn	121	61	[	[	-LRB-
cord-332109-ont0tqpn	121	62	61	61	CD
cord-332109-ont0tqpn	121	63	]	]	-RRB-
cord-332109-ont0tqpn	121	64	[	[	-LRB-
cord-332109-ont0tqpn	121	65	62	62	CD
cord-332109-ont0tqpn	121	66	]	]	-RRB-
cord-332109-ont0tqpn	121	67	[	[	-LRB-
cord-332109-ont0tqpn	121	68	63	63	CD
cord-332109-ont0tqpn	121	69	]	]	-RRB-
cord-332109-ont0tqpn	121	70	.	.	.
cord-332109-ont0tqpn	122	1	Although	although	IN
cord-332109-ont0tqpn	122	2	there	there	EX
cord-332109-ont0tqpn	122	3	has	have	VBZ
cord-332109-ont0tqpn	122	4	been	be	VBN
cord-332109-ont0tqpn	122	5	no	no	DT
cord-332109-ont0tqpn	122	6	reported	report	VBN
cord-332109-ont0tqpn	122	7	evidence	evidence	NN
cord-332109-ont0tqpn	122	8	,	,	,
cord-332109-ont0tqpn	122	9	it	-PRON-	PRP
cord-332109-ont0tqpn	122	10	is	be	VBZ
cord-332109-ont0tqpn	122	11	possible	possible	JJ
cord-332109-ont0tqpn	122	12	that	that	IN
cord-332109-ont0tqpn	122	13	pattern	pattern	NN
cord-332109-ont0tqpn	122	14	recognition	recognition	NN
cord-332109-ont0tqpn	122	15	receptors	receptor	NNS
cord-332109-ont0tqpn	122	16	,	,	,
cord-332109-ont0tqpn	122	17	such	such	JJ
cord-332109-ont0tqpn	122	18	as	as	IN
cord-332109-ont0tqpn	122	19	toll	toll	NN
cord-332109-ont0tqpn	122	20	-	-	HYPH
cord-332109-ont0tqpn	122	21	like	like	JJ
cord-332109-ont0tqpn	122	22	receptors	receptor	NNS
cord-332109-ont0tqpn	122	23	(	(	-LRB-
cord-332109-ont0tqpn	122	24	TLR3	TLR3	NNP
cord-332109-ont0tqpn	122	25	,	,	,
cord-332109-ont0tqpn	122	26	TLR7	TLR7	NNP
cord-332109-ont0tqpn	122	27	,	,	,
cord-332109-ont0tqpn	122	28	and	and	CC
cord-332109-ont0tqpn	122	29	TLR8	TLR8	NNP
cord-332109-ont0tqpn	122	30	)	)	-RRB-
cord-332109-ont0tqpn	122	31	,	,	,
cord-332109-ont0tqpn	122	32	RIG	rig	NN
cord-332109-ont0tqpn	122	33	-	-	:
cord-332109-ont0tqpn	122	34	I	I	NNP
cord-332109-ont0tqpn	122	35	,	,	,
cord-332109-ont0tqpn	122	36	and	and	CC
cord-332109-ont0tqpn	122	37	nucleotide	nucleotide	NN
cord-332109-ont0tqpn	122	38	-	-	HYPH
cord-332109-ont0tqpn	122	39	binding	bind	VBG
cord-332109-ont0tqpn	122	40	oligomerization	oligomerization	NN
cord-332109-ont0tqpn	122	41	domain	domain	NN
cord-332109-ont0tqpn	122	42	(	(	-LRB-
cord-332109-ont0tqpn	122	43	NOD)-like	nod)-like	CD
cord-332109-ont0tqpn	122	44	receptors	receptor	NNS
cord-332109-ont0tqpn	122	45	(	(	-LRB-
cord-332109-ont0tqpn	123	1	NLRP1	NLRP1	NNP
cord-332109-ont0tqpn	123	2	,	,	,
cord-332109-ont0tqpn	123	3	NLRP3	nlrp3	XX
cord-332109-ont0tqpn	123	4	,	,	,
cord-332109-ont0tqpn	123	5	and	and	CC
cord-332109-ont0tqpn	123	6	NLRP12	NLRP12	NNP
cord-332109-ont0tqpn	123	7	)	)	-RRB-
cord-332109-ont0tqpn	123	8	,	,	,
cord-332109-ont0tqpn	123	9	are	be	VBP
cord-332109-ont0tqpn	123	10	also	also	RB
cord-332109-ont0tqpn	123	11	activated	activate	VBN
cord-332109-ont0tqpn	123	12	by	by	IN
cord-332109-ont0tqpn	123	13	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	123	14	through	through	IN
cord-332109-ont0tqpn	123	15	innate	innate	JJ
cord-332109-ont0tqpn	123	16	immunity	immunity	NN
cord-332109-ont0tqpn	123	17	[	[	-LRB-
cord-332109-ont0tqpn	123	18	64	64	CD
cord-332109-ont0tqpn	123	19	]	]	-RRB-
cord-332109-ont0tqpn	123	20	.	.	.
cord-332109-ont0tqpn	124	1	It	-PRON-	PRP
cord-332109-ont0tqpn	124	2	has	have	VBZ
cord-332109-ont0tqpn	124	3	been	be	VBN
cord-332109-ont0tqpn	124	4	reported	report	VBN
cord-332109-ont0tqpn	124	5	that	that	IN
cord-332109-ont0tqpn	124	6	IL-6	IL-6	NNP
cord-332109-ont0tqpn	124	7	was	be	VBD
cord-332109-ont0tqpn	124	8	significantly	significantly	RB
cord-332109-ont0tqpn	124	9	increased	increase	VBN
cord-332109-ont0tqpn	124	10	in	in	IN
cord-332109-ont0tqpn	124	11	severe	severe	JJ
cord-332109-ont0tqpn	124	12	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	124	13	cases	case	NNS
cord-332109-ont0tqpn	124	14	,	,	,
cord-332109-ont0tqpn	124	15	and	and	CC
cord-332109-ont0tqpn	124	16	its	-PRON-	PRP$
cord-332109-ont0tqpn	124	17	level	level	NN
cord-332109-ont0tqpn	124	18	was	be	VBD
cord-332109-ont0tqpn	124	19	closely	closely	RB
cord-332109-ont0tqpn	124	20	correlated	correlate	VBN
cord-332109-ont0tqpn	124	21	with	with	IN
cord-332109-ont0tqpn	124	22	the	the	DT
cord-332109-ont0tqpn	124	23	severity	severity	NN
cord-332109-ont0tqpn	124	24	of	of	IN
cord-332109-ont0tqpn	124	25	patients	patient	NNS
cord-332109-ont0tqpn	124	26	[	[	-LRB-
cord-332109-ont0tqpn	124	27	65	65	CD
cord-332109-ont0tqpn	124	28	]	]	-RRB-
cord-332109-ont0tqpn	124	29	.	.	.
cord-332109-ont0tqpn	125	1	Human	human	JJ
cord-332109-ont0tqpn	125	2	bronchial	bronchial	JJ
cord-332109-ont0tqpn	125	3	epithelial	epithelial	JJ
cord-332109-ont0tqpn	125	4	cells	cell	NNS
cord-332109-ont0tqpn	125	5	infected	infect	VBN
cord-332109-ont0tqpn	125	6	with	with	IN
cord-332109-ont0tqpn	125	7	SARS	SARS	NNP
cord-332109-ont0tqpn	125	8	-	-	HYPH
cord-332109-ont0tqpn	125	9	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	125	10	showed	show	VBD
cord-332109-ont0tqpn	125	11	elevated	elevated	JJ
cord-332109-ont0tqpn	125	12	expression	expression	NN
cord-332109-ont0tqpn	125	13	of	of	IN
cord-332109-ont0tqpn	125	14	type	type	NN
cord-332109-ont0tqpn	125	15	I	-PRON-	PRP
cord-332109-ont0tqpn	125	16	and	and	CC
cord-332109-ont0tqpn	125	17	type	type	NN
cord-332109-ont0tqpn	125	18	III	iii	CD
cord-332109-ont0tqpn	125	19	IFNs	ifn	NNS
cord-332109-ont0tqpn	125	20	and	and	CC
cord-332109-ont0tqpn	125	21	IL-6	IL-6	NNP
cord-332109-ont0tqpn	125	22	[	[	-LRB-
cord-332109-ont0tqpn	125	23	44	44	CD
cord-332109-ont0tqpn	125	24	]	]	-RRB-
cord-332109-ont0tqpn	125	25	.	.	.
cord-332109-ont0tqpn	126	1	Furthermore	furthermore	RB
cord-332109-ont0tqpn	126	2	,	,	,
cord-332109-ont0tqpn	126	3	type	type	NN
cord-332109-ont0tqpn	126	4	I	-PRON-	PRP
cord-332109-ont0tqpn	127	1	interferon	interferon	NN
cord-332109-ont0tqpn	127	2	,	,	,
cord-332109-ont0tqpn	127	3	IFN	IFN	NNP
cord-332109-ont0tqpn	127	4	-	-	HYPH
cord-332109-ont0tqpn	127	5	α	α	NNP
cord-332109-ont0tqpn	127	6	,	,	,
cord-332109-ont0tqpn	127	7	stimulates	stimulate	VBZ
cord-332109-ont0tqpn	127	8	the	the	DT
cord-332109-ont0tqpn	127	9	expression	expression	NN
cord-332109-ont0tqpn	127	10	of	of	IN
cord-332109-ont0tqpn	127	11	ACE2	ACE2	NNP
cord-332109-ont0tqpn	127	12	,	,	,
cord-332109-ont0tqpn	127	13	the	the	DT
cord-332109-ont0tqpn	127	14	molecular	molecular	JJ
cord-332109-ont0tqpn	127	15	target	target	NN
cord-332109-ont0tqpn	127	16	of	of	IN
cord-332109-ont0tqpn	127	17	SARS	SARS	NNP
cord-332109-ont0tqpn	127	18	-	-	HYPH
cord-332109-ont0tqpn	127	19	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	127	20	,	,	,
cord-332109-ont0tqpn	127	21	in	in	IN
cord-332109-ont0tqpn	127	22	primary	primary	JJ
cord-332109-ont0tqpn	127	23	human	human	JJ
cord-332109-ont0tqpn	127	24	nasal	nasal	NN
cord-332109-ont0tqpn	127	25	epithelial	epithelial	JJ
cord-332109-ont0tqpn	127	26	cells	cell	NNS
cord-332109-ont0tqpn	127	27	[	[	-LRB-
cord-332109-ont0tqpn	127	28	43	43	CD
cord-332109-ont0tqpn	127	29	]	]	-RRB-
cord-332109-ont0tqpn	127	30	.	.	.
cord-332109-ont0tqpn	128	1	Type	type	NN
cord-332109-ont0tqpn	128	2	III	III	NNP
cord-332109-ont0tqpn	129	1	interferon	interferon	NN
cord-332109-ont0tqpn	129	2	,	,	,
cord-332109-ont0tqpn	129	3	IFN	IFN	NNP
cord-332109-ont0tqpn	129	4	-	-	HYPH
cord-332109-ont0tqpn	129	5	λ	λ	NNP
cord-332109-ont0tqpn	129	6	,	,	,
cord-332109-ont0tqpn	129	7	has	have	VBZ
cord-332109-ont0tqpn	129	8	been	be	VBN
cord-332109-ont0tqpn	129	9	shown	show	VBN
cord-332109-ont0tqpn	129	10	to	to	TO
cord-332109-ont0tqpn	129	11	disrupt	disrupt	VB
cord-332109-ont0tqpn	129	12	the	the	DT
cord-332109-ont0tqpn	129	13	lung	lung	NN
cord-332109-ont0tqpn	129	14	epithelial	epithelial	JJ
cord-332109-ont0tqpn	129	15	barrier	barrier	NN
cord-332109-ont0tqpn	129	16	by	by	IN
cord-332109-ont0tqpn	129	17	direct	direct	JJ
cord-332109-ont0tqpn	129	18	inhibition	inhibition	NN
cord-332109-ont0tqpn	129	19	of	of	IN
cord-332109-ont0tqpn	129	20	lung	lung	NN
cord-332109-ont0tqpn	129	21	epithelial	epithelial	NN
cord-332109-ont0tqpn	129	22	proliferation	proliferation	NN
cord-332109-ont0tqpn	129	23	and	and	CC
cord-332109-ont0tqpn	129	24	repair	repair	NN
cord-332109-ont0tqpn	129	25	,	,	,
cord-332109-ont0tqpn	129	26	contributing	contribute	VBG
cord-332109-ont0tqpn	129	27	to	to	IN
cord-332109-ont0tqpn	129	28	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	129	29	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	129	30	in	in	IN
cord-332109-ont0tqpn	129	31	the	the	DT
cord-332109-ont0tqpn	129	32	lower	low	JJR
cord-332109-ont0tqpn	129	33	airways	airway	NNS
cord-332109-ont0tqpn	130	1	[	[	-LRB-
cord-332109-ont0tqpn	130	2	66	66	CD
cord-332109-ont0tqpn	130	3	]	]	-RRB-
cord-332109-ont0tqpn	130	4	.	.	.
cord-332109-ont0tqpn	131	1	The	the	DT
cord-332109-ont0tqpn	131	2	upregulation	upregulation	NN
cord-332109-ont0tqpn	131	3	of	of	IN
cord-332109-ont0tqpn	131	4	IL-6	IL-6	NNP
cord-332109-ont0tqpn	131	5	and	and	CC
cord-332109-ont0tqpn	131	6	other	other	JJ
cord-332109-ont0tqpn	131	7	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	131	8	cytokines	cytokine	NNS
cord-332109-ont0tqpn	131	9	was	be	VBD
cord-332109-ont0tqpn	131	10	also	also	RB
cord-332109-ont0tqpn	131	11	observed	observe	VBN
cord-332109-ont0tqpn	131	12	in	in	IN
cord-332109-ont0tqpn	131	13	SARS	SARS	NNP
cord-332109-ont0tqpn	131	14	cases	case	NNS
cord-332109-ont0tqpn	131	15	[	[	-LRB-
cord-332109-ont0tqpn	131	16	67	67	CD
cord-332109-ont0tqpn	131	17	]	]	-RRB-
cord-332109-ont0tqpn	131	18	and	and	CC
cord-332109-ont0tqpn	131	19	influenza	influenza	NN
cord-332109-ont0tqpn	131	20	infection	infection	NN
cord-332109-ont0tqpn	131	21	[	[	-LRB-
cord-332109-ont0tqpn	131	22	68	68	CD
cord-332109-ont0tqpn	131	23	]	]	-RRB-
cord-332109-ont0tqpn	131	24	.	.	.
cord-332109-ont0tqpn	132	1	Substances	substance	NNS
cord-332109-ont0tqpn	132	2	of	of	IN
cord-332109-ont0tqpn	132	3	abuse	abuse	NN
cord-332109-ont0tqpn	132	4	can	can	MD
cord-332109-ont0tqpn	132	5	induce	induce	VB
cord-332109-ont0tqpn	132	6	high	high	JJ
cord-332109-ont0tqpn	132	7	level	level	NN
cord-332109-ont0tqpn	132	8	of	of	IN
cord-332109-ont0tqpn	132	9	expression	expression	NN
cord-332109-ont0tqpn	132	10	of	of	IN
cord-332109-ont0tqpn	132	11	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	132	12	cytokines	cytokine	NNS
cord-332109-ont0tqpn	132	13	and	and	CC
cord-332109-ont0tqpn	132	14	chemokines	chemokine	NNS
cord-332109-ont0tqpn	132	15	in	in	IN
cord-332109-ont0tqpn	132	16	the	the	DT
cord-332109-ont0tqpn	132	17	CNS	CNS	NNP
cord-332109-ont0tqpn	132	18	and	and	CC
cord-332109-ont0tqpn	132	19	cause	cause	VB
cord-332109-ont0tqpn	132	20	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	132	21	,	,	,
cord-332109-ont0tqpn	132	22	which	which	WDT
cord-332109-ont0tqpn	132	23	can	can	MD
cord-332109-ont0tqpn	132	24	worsen	worsen	VB
cord-332109-ont0tqpn	132	25	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	132	26	responses	response	NNS
cord-332109-ont0tqpn	132	27	in	in	IN
cord-332109-ont0tqpn	132	28	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	132	29	.	.	.
cord-332109-ont0tqpn	133	1	Details	detail	NNS
cord-332109-ont0tqpn	133	2	will	will	MD
cord-332109-ont0tqpn	133	3	be	be	VB
cord-332109-ont0tqpn	133	4	discussed	discuss	VBN
cord-332109-ont0tqpn	133	5	in	in	IN
cord-332109-ont0tqpn	133	6	the	the	DT
cord-332109-ont0tqpn	133	7	next	next	JJ
cord-332109-ont0tqpn	133	8	section	section	NN
cord-332109-ont0tqpn	133	9	.	.	.
cord-332109-ont0tqpn	134	1	The	the	DT
cord-332109-ont0tqpn	134	2	bidirectional	bidirectional	JJ
cord-332109-ont0tqpn	134	3	communication	communication	NN
cord-332109-ont0tqpn	134	4	between	between	IN
cord-332109-ont0tqpn	134	5	the	the	DT
cord-332109-ont0tqpn	134	6	brain	brain	NN
cord-332109-ont0tqpn	134	7	and	and	CC
cord-332109-ont0tqpn	134	8	the	the	DT
cord-332109-ont0tqpn	134	9	immune	immune	JJ
cord-332109-ont0tqpn	134	10	system	system	NN
cord-332109-ont0tqpn	134	11	plays	play	VBZ
cord-332109-ont0tqpn	134	12	a	a	DT
cord-332109-ont0tqpn	134	13	critical	critical	JJ
cord-332109-ont0tqpn	134	14	role	role	NN
cord-332109-ont0tqpn	134	15	in	in	IN
cord-332109-ont0tqpn	134	16	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	134	17	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	134	18	.	.	.
cord-332109-ont0tqpn	135	1	It	-PRON-	PRP
cord-332109-ont0tqpn	135	2	has	have	VBZ
cord-332109-ont0tqpn	135	3	been	be	VBN
cord-332109-ont0tqpn	135	4	well	well	RB
cord-332109-ont0tqpn	135	5	established	establish	VBN
cord-332109-ont0tqpn	135	6	that	that	IN
cord-332109-ont0tqpn	135	7	brain	brain	NN
cord-332109-ont0tqpn	135	8	-	-	HYPH
cord-332109-ont0tqpn	135	9	immune	immune	JJ
cord-332109-ont0tqpn	135	10	interactions	interaction	NNS
cord-332109-ont0tqpn	135	11	are	be	VBP
cord-332109-ont0tqpn	135	12	widespread	widespread	JJ
cord-332109-ont0tqpn	135	13	and	and	CC
cord-332109-ont0tqpn	135	14	significant	significant	JJ
cord-332109-ont0tqpn	135	15	.	.	.
cord-332109-ont0tqpn	136	1	For	for	IN
cord-332109-ont0tqpn	136	2	instance	instance	NN
cord-332109-ont0tqpn	136	3	,	,	,
cord-332109-ont0tqpn	136	4	the	the	DT
cord-332109-ont0tqpn	136	5	immune	immune	JJ
cord-332109-ont0tqpn	136	6	system	system	NN
cord-332109-ont0tqpn	136	7	produces	produce	VBZ
cord-332109-ont0tqpn	136	8	hormones	hormone	NNS
cord-332109-ont0tqpn	136	9	and	and	CC
cord-332109-ont0tqpn	136	10	neurotransmitters	neurotransmitter	NNS
cord-332109-ont0tqpn	136	11	[	[	-LRB-
cord-332109-ont0tqpn	136	12	69	69	CD
cord-332109-ont0tqpn	136	13	]	]	-RRB-
cord-332109-ont0tqpn	136	14	[	[	-LRB-
cord-332109-ont0tqpn	136	15	70	70	CD
cord-332109-ont0tqpn	136	16	]	]	-RRB-
cord-332109-ont0tqpn	136	17	[	[	-LRB-
cord-332109-ont0tqpn	136	18	71	71	CD
cord-332109-ont0tqpn	136	19	]	]	-RRB-
cord-332109-ont0tqpn	136	20	,	,	,
cord-332109-ont0tqpn	136	21	while	while	IN
cord-332109-ont0tqpn	136	22	the	the	DT
cord-332109-ont0tqpn	136	23	anterior	anterior	JJ
cord-332109-ont0tqpn	136	24	pituitary	pituitary	NN
cord-332109-ont0tqpn	136	25	cells	cell	NNS
cord-332109-ont0tqpn	136	26	in	in	IN
cord-332109-ont0tqpn	136	27	CNS	CNS	NNP
cord-332109-ont0tqpn	136	28	produce	produce	VBP
cord-332109-ont0tqpn	136	29	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	136	30	cytokines	cytokine	NNS
cord-332109-ont0tqpn	136	31	,	,	,
cord-332109-ont0tqpn	136	32	such	such	JJ
cord-332109-ont0tqpn	136	33	as	as	IN
cord-332109-ont0tqpn	136	34	IL-6	IL-6	NNP
cord-332109-ont0tqpn	136	35	[	[	-LRB-
cord-332109-ont0tqpn	136	36	72	72	CD
cord-332109-ont0tqpn	136	37	]	]	-RRB-
cord-332109-ont0tqpn	136	38	.	.	.
cord-332109-ont0tqpn	137	1	Microglial	microglial	JJ
cord-332109-ont0tqpn	137	2	cells	cell	NNS
cord-332109-ont0tqpn	137	3	are	be	VBP
cord-332109-ont0tqpn	137	4	immune	immune	JJ
cord-332109-ont0tqpn	137	5	effectors	effector	NNS
cord-332109-ont0tqpn	137	6	in	in	IN
cord-332109-ont0tqpn	137	7	the	the	DT
cord-332109-ont0tqpn	137	8	CNS	CNS	NNP
cord-332109-ont0tqpn	137	9	,	,	,
cord-332109-ont0tqpn	137	10	which	which	WDT
cord-332109-ont0tqpn	137	11	produce	produce	VBP
cord-332109-ont0tqpn	137	12	and	and	CC
cord-332109-ont0tqpn	137	13	secrete	secrete	JJ
cord-332109-ont0tqpn	137	14	cytokines	cytokine	NNS
cord-332109-ont0tqpn	137	15	and	and	CC
cord-332109-ont0tqpn	137	16	neurotrophic	neurotrophic	NN
cord-332109-ont0tqpn	137	17	or	or	CC
cord-332109-ont0tqpn	137	18	neuron	neuron	NN
cord-332109-ont0tqpn	137	19	survival	survival	NN
cord-332109-ont0tqpn	137	20	factors	factor	NNS
cord-332109-ont0tqpn	137	21	upon	upon	IN
cord-332109-ont0tqpn	137	22	inflammation	inflammation	NN
cord-332109-ont0tqpn	137	23	and	and	CC
cord-332109-ont0tqpn	137	24	injury	injury	NN
cord-332109-ont0tqpn	137	25	[	[	-LRB-
cord-332109-ont0tqpn	137	26	73	73	CD
cord-332109-ont0tqpn	137	27	]	]	-RRB-
cord-332109-ont0tqpn	137	28	.	.	.
cord-332109-ont0tqpn	138	1	For	for	IN
cord-332109-ont0tqpn	138	2	pathogen	pathogen	NN
cord-332109-ont0tqpn	138	3	infections	infection	NNS
cord-332109-ont0tqpn	138	4	,	,	,
cord-332109-ont0tqpn	138	5	the	the	DT
cord-332109-ont0tqpn	138	6	innate	innate	JJ
cord-332109-ont0tqpn	138	7	immunity	immunity	NN
cord-332109-ont0tqpn	138	8	provides	provide	VBZ
cord-332109-ont0tqpn	138	9	the	the	DT
cord-332109-ont0tqpn	138	10	first	first	JJ
cord-332109-ont0tqpn	138	11	line	line	NN
cord-332109-ont0tqpn	138	12	of	of	IN
cord-332109-ont0tqpn	138	13	defense	defense	NN
cord-332109-ont0tqpn	138	14	through	through	IN
cord-332109-ont0tqpn	138	15	recognition	recognition	NN
cord-332109-ont0tqpn	138	16	of	of	IN
cord-332109-ont0tqpn	138	17	pathogen	pathogen	NN
cord-332109-ont0tqpn	138	18	-	-	HYPH
cord-332109-ont0tqpn	138	19	associated	associate	VBN
cord-332109-ont0tqpn	138	20	molecular	molecular	JJ
cord-332109-ont0tqpn	138	21	patterns	pattern	NNS
cord-332109-ont0tqpn	138	22	(	(	-LRB-
cord-332109-ont0tqpn	138	23	PAMPs	pamp	NNS
cord-332109-ont0tqpn	138	24	)	)	-RRB-
cord-332109-ont0tqpn	138	25	,	,	,
cord-332109-ont0tqpn	138	26	initiating	initiate	VBG
cord-332109-ont0tqpn	138	27	nonspecific	nonspecific	JJ
cord-332109-ont0tqpn	138	28	cellular	cellular	JJ
cord-332109-ont0tqpn	138	29	and	and	CC
cord-332109-ont0tqpn	138	30	humoral	humoral	JJ
cord-332109-ont0tqpn	138	31	responses	response	NNS
cord-332109-ont0tqpn	138	32	and	and	CC
cord-332109-ont0tqpn	138	33	rapidly	rapidly	RB
cord-332109-ont0tqpn	138	34	activating	activate	VBG
cord-332109-ont0tqpn	138	35	nonspecific	nonspecific	JJ
cord-332109-ont0tqpn	138	36	neural	neural	JJ
cord-332109-ont0tqpn	138	37	responses	response	NNS
cord-332109-ont0tqpn	138	38	,	,	,
cord-332109-ont0tqpn	138	39	including	include	VBG
cord-332109-ont0tqpn	138	40	systemic	systemic	JJ
cord-332109-ont0tqpn	138	41	hormonal	hormonal	JJ
cord-332109-ont0tqpn	138	42	responses	response	NNS
cord-332109-ont0tqpn	138	43	through	through	IN
cord-332109-ont0tqpn	138	44	the	the	DT
cord-332109-ont0tqpn	138	45	hypothalamic	hypothalamic	JJ
cord-332109-ont0tqpn	138	46	-	-	HYPH
cord-332109-ont0tqpn	138	47	pituitary	pituitary	NN
cord-332109-ont0tqpn	138	48	-	-	HYPH
cord-332109-ont0tqpn	138	49	adrenal	adrenal	NN
cord-332109-ont0tqpn	138	50	(	(	-LRB-
cord-332109-ont0tqpn	138	51	HPA	HPA	NNP
cord-332109-ont0tqpn	138	52	)	)	-RRB-
cord-332109-ont0tqpn	138	53	axis	axis	NN
cord-332109-ont0tqpn	139	1	(	(	-LRB-
cord-332109-ont0tqpn	139	2	Figure	figure	NN
cord-332109-ont0tqpn	139	3	3	3	CD
cord-332109-ont0tqpn	139	4	)	)	-RRB-
cord-332109-ont0tqpn	139	5	[	[	-LRB-
cord-332109-ont0tqpn	139	6	74	74	CD
cord-332109-ont0tqpn	139	7	]	]	-RRB-
cord-332109-ont0tqpn	139	8	.	.	.
cord-332109-ont0tqpn	140	1	Consisting	consist	VBG
cord-332109-ont0tqpn	140	2	of	of	IN
cord-332109-ont0tqpn	140	3	the	the	DT
cord-332109-ont0tqpn	140	4	hypothalamus	hypothalamus	NN
cord-332109-ont0tqpn	140	5	of	of	IN
cord-332109-ont0tqpn	140	6	the	the	DT
cord-332109-ont0tqpn	140	7	brain	brain	NN
cord-332109-ont0tqpn	140	8	,	,	,
cord-332109-ont0tqpn	140	9	and	and	CC
cord-332109-ont0tqpn	140	10	endocrine	endocrine	JJ
cord-332109-ont0tqpn	140	11	organs	organ	NNS
cord-332109-ont0tqpn	140	12	,	,	,
cord-332109-ont0tqpn	140	13	the	the	DT
cord-332109-ont0tqpn	140	14	pituitary	pituitary	NN
cord-332109-ont0tqpn	140	15	and	and	CC
cord-332109-ont0tqpn	140	16	cortex	cortex	NN
cord-332109-ont0tqpn	140	17	of	of	IN
cord-332109-ont0tqpn	140	18	the	the	DT
cord-332109-ont0tqpn	140	19	adrenal	adrenal	JJ
cord-332109-ont0tqpn	140	20	glands	gland	NNS
cord-332109-ont0tqpn	140	21	,	,	,
cord-332109-ont0tqpn	140	22	the	the	DT
cord-332109-ont0tqpn	140	23	HPA	HPA	NNP
cord-332109-ont0tqpn	140	24	axis	axis	NN
cord-332109-ont0tqpn	140	25	is	be	VBZ
cord-332109-ont0tqpn	140	26	responsible	responsible	JJ
cord-332109-ont0tqpn	140	27	for	for	IN
cord-332109-ont0tqpn	140	28	systematic	systematic	JJ
cord-332109-ont0tqpn	140	29	inflammation	inflammation	NN
cord-332109-ont0tqpn	140	30	control	control	NN
cord-332109-ont0tqpn	140	31	.	.	.
cord-332109-ont0tqpn	141	1	The	the	DT
cord-332109-ont0tqpn	141	2	paraventricular	paraventricular	JJ
cord-332109-ont0tqpn	141	3	nucleus	nucleus	NN
cord-332109-ont0tqpn	141	4	(	(	-LRB-
cord-332109-ont0tqpn	141	5	PVN	PVN	NNP
cord-332109-ont0tqpn	141	6	)	)	-RRB-
cord-332109-ont0tqpn	141	7	of	of	IN
cord-332109-ont0tqpn	141	8	the	the	DT
cord-332109-ont0tqpn	141	9	hypothalamus	hypothalamus	NN
cord-332109-ont0tqpn	141	10	plays	play	VBZ
cord-332109-ont0tqpn	141	11	the	the	DT
cord-332109-ont0tqpn	141	12	main	main	JJ
cord-332109-ont0tqpn	141	13	governing	govern	VBG
cord-332109-ont0tqpn	141	14	role	role	NN
cord-332109-ont0tqpn	141	15	of	of	IN
cord-332109-ont0tqpn	141	16	the	the	DT
cord-332109-ont0tqpn	141	17	HPA	HPA	NNP
cord-332109-ont0tqpn	141	18	axis	axis	NN
cord-332109-ont0tqpn	141	19	,	,	,
cord-332109-ont0tqpn	141	20	releasing	release	VBG
cord-332109-ont0tqpn	141	21	a	a	DT
cord-332109-ont0tqpn	141	22	wide	wide	JJ
cord-332109-ont0tqpn	141	23	range	range	NN
cord-332109-ont0tqpn	141	24	of	of	IN
cord-332109-ont0tqpn	141	25	neuropeptides	neuropeptide	NNS
cord-332109-ont0tqpn	141	26	,	,	,
cord-332109-ont0tqpn	141	27	including	include	VBG
cord-332109-ont0tqpn	141	28	the	the	DT
cord-332109-ont0tqpn	141	29	corticotrophin	corticotrophin	NN
cord-332109-ont0tqpn	141	30	-	-	HYPH
cord-332109-ont0tqpn	141	31	releasing	release	VBG
cord-332109-ont0tqpn	141	32	hormone	hormone	NN
cord-332109-ont0tqpn	141	33	(	(	-LRB-
cord-332109-ont0tqpn	141	34	CRH	CRH	NNP
cord-332109-ont0tqpn	141	35	)	)	-RRB-
cord-332109-ont0tqpn	141	36	and	and	CC
cord-332109-ont0tqpn	141	37	arginin	arginin	NN
cord-332109-ont0tqpn	141	38	-	-	HYPH
cord-332109-ont0tqpn	141	39	vasopressin	vasopressin	NN
cord-332109-ont0tqpn	141	40	(	(	-LRB-
cord-332109-ont0tqpn	141	41	AVP	AVP	NNP
cord-332109-ont0tqpn	141	42	)	)	-RRB-
cord-332109-ont0tqpn	141	43	.	.	.
cord-332109-ont0tqpn	142	1	These	these	DT
cord-332109-ont0tqpn	142	2	neuropeptides	neuropeptide	NNS
cord-332109-ont0tqpn	142	3	reach	reach	VBP
cord-332109-ont0tqpn	142	4	the	the	DT
cord-332109-ont0tqpn	142	5	anterior	anterior	JJ
cord-332109-ont0tqpn	142	6	pituitary	pituitary	NN
cord-332109-ont0tqpn	142	7	(	(	-LRB-
cord-332109-ont0tqpn	142	8	AP	AP	NNP
cord-332109-ont0tqpn	142	9	)	)	-RRB-
cord-332109-ont0tqpn	142	10	to	to	TO
cord-332109-ont0tqpn	142	11	activate	activate	VB
cord-332109-ont0tqpn	142	12	corticotrope	corticotrope	NN
cord-332109-ont0tqpn	142	13	cells	cell	NNS
cord-332109-ont0tqpn	142	14	to	to	TO
cord-332109-ont0tqpn	142	15	secrete	secrete	VB
cord-332109-ont0tqpn	142	16	adrenocorticotropic	adrenocorticotropic	JJ
cord-332109-ont0tqpn	142	17	hormone	hormone	NN
cord-332109-ont0tqpn	142	18	(	(	-LRB-
cord-332109-ont0tqpn	142	19	ACTH	ACTH	NNP
cord-332109-ont0tqpn	142	20	)	)	-RRB-
cord-332109-ont0tqpn	142	21	.	.	.
cord-332109-ont0tqpn	143	1	ACTH	ACTH	NNP
cord-332109-ont0tqpn	143	2	subsequently	subsequently	RB
cord-332109-ont0tqpn	143	3	enables	enable	VBZ
cord-332109-ont0tqpn	143	4	the	the	DT
cord-332109-ont0tqpn	143	5	synthesis	synthesis	NN
cord-332109-ont0tqpn	143	6	and	and	CC
cord-332109-ont0tqpn	143	7	secretion	secretion	NN
cord-332109-ont0tqpn	143	8	of	of	IN
cord-332109-ont0tqpn	143	9	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	143	10	in	in	IN
cord-332109-ont0tqpn	143	11	the	the	DT
cord-332109-ont0tqpn	143	12	zona	zona	NNP
cord-332109-ont0tqpn	143	13	fasciculata	fasciculata	NNP
cord-332109-ont0tqpn	143	14	of	of	IN
cord-332109-ont0tqpn	143	15	the	the	DT
cord-332109-ont0tqpn	143	16	adrenal	adrenal	JJ
cord-332109-ont0tqpn	143	17	cortex	cortex	NN
cord-332109-ont0tqpn	143	18	through	through	IN
cord-332109-ont0tqpn	143	19	melanocortin	melanocortin	NNP
cord-332109-ont0tqpn	143	20	type	type	NN
cord-332109-ont0tqpn	143	21	2	2	CD
cord-332109-ont0tqpn	143	22	receptors	receptor	NNS
cord-332109-ont0tqpn	143	23	[	[	-LRB-
cord-332109-ont0tqpn	143	24	75	75	CD
cord-332109-ont0tqpn	143	25	]	]	-RRB-
cord-332109-ont0tqpn	143	26	.	.	.
cord-332109-ont0tqpn	144	1	The	the	DT
cord-332109-ont0tqpn	144	2	physiological	physiological	JJ
cord-332109-ont0tqpn	144	3	feedback	feedback	NN
cord-332109-ont0tqpn	144	4	loop	loop	NN
cord-332109-ont0tqpn	144	5	involves	involve	VBZ
cord-332109-ont0tqpn	144	6	releasing	release	VBG
cord-332109-ont0tqpn	144	7	immune	immune	JJ
cord-332109-ont0tqpn	144	8	mediators	mediator	NNS
cord-332109-ont0tqpn	144	9	and	and	CC
cord-332109-ont0tqpn	144	10	cytokines	cytokine	NNS
cord-332109-ont0tqpn	144	11	,	,	,
cord-332109-ont0tqpn	144	12	such	such	JJ
cord-332109-ont0tqpn	144	13	as	as	IN
cord-332109-ont0tqpn	144	14	IL-1	IL-1	NNP
cord-332109-ont0tqpn	144	15	,	,	,
cord-332109-ont0tqpn	144	16	IL-6	IL-6	NNP
cord-332109-ont0tqpn	144	17	,	,	,
cord-332109-ont0tqpn	144	18	and	and	CC
cord-332109-ont0tqpn	144	19	tumor	tumor	NN
cord-332109-ont0tqpn	144	20	-	-	HYPH
cord-332109-ont0tqpn	144	21	necrosis	necrosis	NN
cord-332109-ont0tqpn	144	22	factors	factor	NNS
cord-332109-ont0tqpn	144	23	(	(	-LRB-
cord-332109-ont0tqpn	144	24	TNFs	TNFs	NNP
cord-332109-ont0tqpn	144	25	)	)	-RRB-
cord-332109-ont0tqpn	144	26	,	,	,
cord-332109-ont0tqpn	144	27	by	by	IN
cord-332109-ont0tqpn	144	28	the	the	DT
cord-332109-ont0tqpn	144	29	innate	innate	JJ
cord-332109-ont0tqpn	144	30	immune	immune	JJ
cord-332109-ont0tqpn	144	31	system	system	NN
cord-332109-ont0tqpn	144	32	to	to	TO
cord-332109-ont0tqpn	144	33	activate	activate	VB
cord-332109-ont0tqpn	144	34	neural	neural	JJ
cord-332109-ont0tqpn	144	35	responses	response	NNS
cord-332109-ont0tqpn	144	36	,	,	,
cord-332109-ont0tqpn	144	37	which	which	WDT
cord-332109-ont0tqpn	144	38	amplify	amplify	VBP
cord-332109-ont0tqpn	144	39	local	local	JJ
cord-332109-ont0tqpn	144	40	inflammation	inflammation	NN
cord-332109-ont0tqpn	144	41	to	to	TO
cord-332109-ont0tqpn	144	42	contain	contain	VB
cord-332109-ont0tqpn	144	43	and	and	CC
cord-332109-ont0tqpn	144	44	eliminate	eliminate	VB
cord-332109-ont0tqpn	144	45	pathogen	pathogen	NN
cord-332109-ont0tqpn	144	46	invasions	invasion	NNS
cord-332109-ont0tqpn	144	47	.	.	.
cord-332109-ont0tqpn	145	1	Upon	upon	IN
cord-332109-ont0tqpn	145	2	pathogen	pathogen	NN
cord-332109-ont0tqpn	145	3	clearance	clearance	NN
cord-332109-ont0tqpn	145	4	,	,	,
cord-332109-ont0tqpn	145	5	the	the	DT
cord-332109-ont0tqpn	145	6	brain	brain	NN
cord-332109-ont0tqpn	145	7	responds	respond	VBZ
cord-332109-ont0tqpn	145	8	by	by	IN
cord-332109-ont0tqpn	145	9	activating	activate	VBG
cord-332109-ont0tqpn	145	10	the	the	DT
cord-332109-ont0tqpn	145	11	HPA	HPA	NNP
cord-332109-ont0tqpn	145	12	axis	axis	NN
cord-332109-ont0tqpn	145	13	and	and	CC
cord-332109-ont0tqpn	145	14	releasing	release	VBG
cord-332109-ont0tqpn	145	15	anti	anti	JJ
cord-332109-ont0tqpn	145	16	-	-	JJ
cord-332109-ont0tqpn	145	17	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	145	18	molecules	molecule	NNS
cord-332109-ont0tqpn	145	19	,	,	,
cord-332109-ont0tqpn	145	20	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	145	21	,	,	,
cord-332109-ont0tqpn	145	22	from	from	IN
cord-332109-ont0tqpn	145	23	the	the	DT
cord-332109-ont0tqpn	145	24	adrenal	adrenal	JJ
cord-332109-ont0tqpn	145	25	cortex	cortex	NN
cord-332109-ont0tqpn	145	26	.	.	.
cord-332109-ont0tqpn	146	1	The	the	DT
cord-332109-ont0tqpn	146	2	release	release	NN
cord-332109-ont0tqpn	146	3	of	of	IN
cord-332109-ont0tqpn	146	4	this	this	DT
cord-332109-ont0tqpn	146	5	final	final	JJ
cord-332109-ont0tqpn	146	6	product	product	NN
cord-332109-ont0tqpn	146	7	of	of	IN
cord-332109-ont0tqpn	146	8	the	the	DT
cord-332109-ont0tqpn	146	9	HPA	HPA	NNP
cord-332109-ont0tqpn	146	10	axis	axis	NN
cord-332109-ont0tqpn	146	11	sends	send	VBZ
cord-332109-ont0tqpn	146	12	a	a	DT
cord-332109-ont0tqpn	146	13	signal	signal	NN
cord-332109-ont0tqpn	146	14	to	to	IN
cord-332109-ont0tqpn	146	15	the	the	DT
cord-332109-ont0tqpn	146	16	immune	immune	JJ
cord-332109-ont0tqpn	146	17	system	system	NN
cord-332109-ont0tqpn	146	18	to	to	TO
cord-332109-ont0tqpn	146	19	terminate	terminate	VB
cord-332109-ont0tqpn	146	20	the	the	DT
cord-332109-ont0tqpn	146	21	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	146	22	responses	response	NNS
cord-332109-ont0tqpn	146	23	,	,	,
cord-332109-ont0tqpn	146	24	completing	complete	VBG
cord-332109-ont0tqpn	146	25	the	the	DT
cord-332109-ont0tqpn	146	26	hormonal	hormonal	JJ
cord-332109-ont0tqpn	146	27	negative	negative	JJ
cord-332109-ont0tqpn	146	28	-	-	HYPH
cord-332109-ont0tqpn	146	29	feedback	feedback	NN
cord-332109-ont0tqpn	146	30	loop	loop	NN
cord-332109-ont0tqpn	146	31	.	.	.
cord-332109-ont0tqpn	147	1	Glucocorticoids	Glucocorticoids	NNP
cord-332109-ont0tqpn	147	2	also	also	RB
cord-332109-ont0tqpn	147	3	negatively	negatively	RB
cord-332109-ont0tqpn	147	4	regulate	regulate	VBP
cord-332109-ont0tqpn	147	5	the	the	DT
cord-332109-ont0tqpn	147	6	HPA	HPA	NNP
cord-332109-ont0tqpn	147	7	axis	axis	NN
cord-332109-ont0tqpn	147	8	itself	-PRON-	PRP
cord-332109-ont0tqpn	147	9	,	,	,
cord-332109-ont0tqpn	147	10	restoring	restore	VBG
cord-332109-ont0tqpn	147	11	host	host	NN
cord-332109-ont0tqpn	147	12	homeostasis	homeostasis	NN
cord-332109-ont0tqpn	147	13	,	,	,
cord-332109-ont0tqpn	147	14	including	include	VBG
cord-332109-ont0tqpn	147	15	CNS	CNS	NNP
cord-332109-ont0tqpn	147	16	and	and	CC
cord-332109-ont0tqpn	147	17	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	147	18	system	system	NN
cord-332109-ont0tqpn	147	19	,	,	,
cord-332109-ont0tqpn	147	20	as	as	RB
cord-332109-ont0tqpn	147	21	well	well	RB
cord-332109-ont0tqpn	147	22	as	as	IN
cord-332109-ont0tqpn	147	23	metabolic	metabolic	JJ
cord-332109-ont0tqpn	147	24	balances	balance	NNS
cord-332109-ont0tqpn	147	25	.	.	.
cord-332109-ont0tqpn	148	1	The	the	DT
cord-332109-ont0tqpn	148	2	interplay	interplay	NN
cord-332109-ont0tqpn	148	3	between	between	IN
cord-332109-ont0tqpn	148	4	the	the	DT
cord-332109-ont0tqpn	148	5	nervous	nervous	JJ
cord-332109-ont0tqpn	148	6	system	system	NN
cord-332109-ont0tqpn	148	7	and	and	CC
cord-332109-ont0tqpn	148	8	the	the	DT
cord-332109-ont0tqpn	148	9	immune	immune	JJ
cord-332109-ont0tqpn	148	10	system	system	NN
cord-332109-ont0tqpn	148	11	plays	play	VBZ
cord-332109-ont0tqpn	148	12	a	a	DT
cord-332109-ont0tqpn	148	13	critical	critical	JJ
cord-332109-ont0tqpn	148	14	role	role	NN
cord-332109-ont0tqpn	148	15	in	in	IN
cord-332109-ont0tqpn	148	16	forming	form	VBG
cord-332109-ont0tqpn	148	17	a	a	DT
cord-332109-ont0tqpn	148	18	cohesive	cohesive	JJ
cord-332109-ont0tqpn	148	19	and	and	CC
cord-332109-ont0tqpn	148	20	integrated	integrated	JJ
cord-332109-ont0tqpn	148	21	early	early	JJ
cord-332109-ont0tqpn	148	22	host	host	NN
cord-332109-ont0tqpn	148	23	response	response	NN
cord-332109-ont0tqpn	148	24	for	for	IN
cord-332109-ont0tqpn	148	25	pathogen	pathogen	NN
cord-332109-ont0tqpn	148	26	clearance	clearance	NN
cord-332109-ont0tqpn	148	27	through	through	IN
cord-332109-ont0tqpn	148	28	an	an	DT
cord-332109-ont0tqpn	148	29	optimized	optimize	VBN
cord-332109-ont0tqpn	148	30	innate	innate	JJ
cord-332109-ont0tqpn	148	31	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	148	32	response	response	NN
cord-332109-ont0tqpn	148	33	.	.	.
cord-332109-ont0tqpn	149	1	Impairment	impairment	NN
cord-332109-ont0tqpn	149	2	of	of	IN
cord-332109-ont0tqpn	149	3	the	the	DT
cord-332109-ont0tqpn	149	4	HPA	HPA	NNP
cord-332109-ont0tqpn	149	5	axis	axis	NN
cord-332109-ont0tqpn	149	6	by	by	IN
cord-332109-ont0tqpn	149	7	various	various	JJ
cord-332109-ont0tqpn	149	8	substances	substance	NNS
cord-332109-ont0tqpn	149	9	of	of	IN
cord-332109-ont0tqpn	149	10	abuse	abuse	NN
cord-332109-ont0tqpn	149	11	could	could	MD
cord-332109-ont0tqpn	149	12	render	render	VB
cord-332109-ont0tqpn	149	13	the	the	DT
cord-332109-ont0tqpn	149	14	host	host	NN
cord-332109-ont0tqpn	149	15	highly	highly	RB
cord-332109-ont0tqpn	149	16	susceptible	susceptible	JJ
cord-332109-ont0tqpn	149	17	to	to	IN
cord-332109-ont0tqpn	149	18	inflammation	inflammation	NN
cord-332109-ont0tqpn	149	19	and	and	CC
cord-332109-ont0tqpn	149	20	even	even	RB
cord-332109-ont0tqpn	149	21	increased	increase	VBD
cord-332109-ont0tqpn	149	22	mortality	mortality	NN
cord-332109-ont0tqpn	149	23	from	from	IN
cord-332109-ont0tqpn	149	24	septic	septic	JJ
cord-332109-ont0tqpn	149	25	shock	shock	NN
cord-332109-ont0tqpn	149	26	from	from	IN
cord-332109-ont0tqpn	149	27	exposure	exposure	NN
cord-332109-ont0tqpn	149	28	to	to	IN
cord-332109-ont0tqpn	149	29	infectious	infectious	JJ
cord-332109-ont0tqpn	149	30	and	and	CC
cord-332109-ont0tqpn	149	31	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	149	32	triggers	trigger	NNS
cord-332109-ont0tqpn	149	33	,	,	,
cord-332109-ont0tqpn	149	34	including	include	VBG
cord-332109-ont0tqpn	149	35	COVID-19	covid-19	VB
cord-332109-ont0tqpn	149	36	.	.	.
cord-332109-ont0tqpn	150	1	Inappropriate	inappropriate	JJ
cord-332109-ont0tqpn	150	2	and	and	CC
cord-332109-ont0tqpn	150	3	excessive	excessive	JJ
cord-332109-ont0tqpn	150	4	CNS	CNS	NNP
cord-332109-ont0tqpn	150	5	responses	response	NNS
cord-332109-ont0tqpn	150	6	could	could	MD
cord-332109-ont0tqpn	150	7	predispose	predispose	VB
cord-332109-ont0tqpn	150	8	the	the	DT
cord-332109-ont0tqpn	150	9	host	host	NN
cord-332109-ont0tqpn	150	10	to	to	IN
cord-332109-ont0tqpn	150	11	extreme	extreme	JJ
cord-332109-ont0tqpn	150	12	inflammation	inflammation	NN
cord-332109-ont0tqpn	150	13	,	,	,
cord-332109-ont0tqpn	150	14	including	include	VBG
cord-332109-ont0tqpn	150	15	cytokine	cytokine	NN
cord-332109-ont0tqpn	150	16	storm	storm	NN
cord-332109-ont0tqpn	150	17	that	that	WDT
cord-332109-ont0tqpn	150	18	has	have	VBZ
cord-332109-ont0tqpn	150	19	been	be	VBN
cord-332109-ont0tqpn	150	20	observed	observe	VBN
cord-332109-ont0tqpn	150	21	clinically	clinically	RB
cord-332109-ont0tqpn	150	22	in	in	IN
cord-332109-ont0tqpn	150	23	influenza	influenza	NN
cord-332109-ont0tqpn	150	24	[	[	-LRB-
cord-332109-ont0tqpn	150	25	68	68	CD
cord-332109-ont0tqpn	150	26	,	,	,
cord-332109-ont0tqpn	150	27	76	76	CD
cord-332109-ont0tqpn	150	28	]	]	-RRB-
cord-332109-ont0tqpn	150	29	,	,	,
cord-332109-ont0tqpn	150	30	SARS	SARS	NNP
cord-332109-ont0tqpn	150	31	[	[	-LRB-
cord-332109-ont0tqpn	150	32	77	77	CD
cord-332109-ont0tqpn	150	33	]	]	-RRB-
cord-332109-ont0tqpn	150	34	,	,	,
cord-332109-ont0tqpn	150	35	and	and	CC
cord-332109-ont0tqpn	150	36	COVID-19	covid-19	VBP
cord-332109-ont0tqpn	150	37	[	[	-LRB-
cord-332109-ont0tqpn	150	38	59	59	CD
cord-332109-ont0tqpn	150	39	]	]	-RRB-
cord-332109-ont0tqpn	150	40	.	.	.
cord-332109-ont0tqpn	151	1	Excessive	excessive	JJ
cord-332109-ont0tqpn	151	2	activation	activation	NN
cord-332109-ont0tqpn	151	3	of	of	IN
cord-332109-ont0tqpn	151	4	the	the	DT
cord-332109-ont0tqpn	151	5	HPA	HPA	NNP
cord-332109-ont0tqpn	151	6	axis	axis	NN
cord-332109-ont0tqpn	151	7	and	and	CC
cord-332109-ont0tqpn	151	8	the	the	DT
cord-332109-ont0tqpn	151	9	release	release	NN
cord-332109-ont0tqpn	151	10	of	of	IN
cord-332109-ont0tqpn	151	11	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	151	12	by	by	IN
cord-332109-ont0tqpn	151	13	several	several	JJ
cord-332109-ont0tqpn	151	14	substances	substance	NNS
cord-332109-ont0tqpn	151	15	of	of	IN
cord-332109-ont0tqpn	151	16	abuse	abuse	NN
cord-332109-ont0tqpn	151	17	will	will	MD
cord-332109-ont0tqpn	151	18	suppress	suppress	VB
cord-332109-ont0tqpn	151	19	the	the	DT
cord-332109-ont0tqpn	151	20	activities	activity	NNS
cord-332109-ont0tqpn	151	21	of	of	IN
cord-332109-ont0tqpn	151	22	various	various	JJ
cord-332109-ont0tqpn	151	23	immune	immune	JJ
cord-332109-ont0tqpn	151	24	cells	cell	NNS
cord-332109-ont0tqpn	151	25	,	,	,
cord-332109-ont0tqpn	151	26	including	include	VBG
cord-332109-ont0tqpn	151	27	macrophages	macrophage	NNS
cord-332109-ont0tqpn	151	28	,	,	,
cord-332109-ont0tqpn	151	29	dendritic	dendritic	JJ
cord-332109-ont0tqpn	151	30	cells	cell	NNS
cord-332109-ont0tqpn	151	31	,	,	,
cord-332109-ont0tqpn	151	32	and	and	CC
cord-332109-ont0tqpn	151	33	T	t	NN
cord-332109-ont0tqpn	151	34	cells	cell	NNS
cord-332109-ont0tqpn	151	35	,	,	,
cord-332109-ont0tqpn	151	36	and	and	CC
cord-332109-ont0tqpn	151	37	will	will	MD
cord-332109-ont0tqpn	151	38	inhibit	inhibit	VB
cord-332109-ont0tqpn	151	39	activities	activity	NNS
cord-332109-ont0tqpn	151	40	of	of	IN
cord-332109-ont0tqpn	151	41	NK	NK	NNP
cord-332109-ont0tqpn	151	42	cells	cell	NNS
cord-332109-ont0tqpn	151	43	,	,	,
cord-332109-ont0tqpn	151	44	B	b	NN
cord-332109-ont0tqpn	151	45	cells	cell	NNS
cord-332109-ont0tqpn	151	46	,	,	,
cord-332109-ont0tqpn	151	47	and	and	CC
cord-332109-ont0tqpn	151	48	T	t	NN
cord-332109-ont0tqpn	151	49	cells	cell	NNS
cord-332109-ont0tqpn	151	50	(	(	-LRB-
cord-332109-ont0tqpn	151	51	Figure	figure	NN
cord-332109-ont0tqpn	151	52	3	3	CD
cord-332109-ont0tqpn	151	53	)	)	-RRB-
cord-332109-ont0tqpn	151	54	[	[	-LRB-
cord-332109-ont0tqpn	151	55	74	74	CD
cord-332109-ont0tqpn	151	56	]	]	-RRB-
cord-332109-ont0tqpn	151	57	.	.	.
cord-332109-ont0tqpn	152	1	The	the	DT
cord-332109-ont0tqpn	152	2	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	152	3	reduces	reduce	VBZ
cord-332109-ont0tqpn	152	4	antibody	antibody	NN
cord-332109-ont0tqpn	152	5	production	production	NN
cord-332109-ont0tqpn	152	6	,	,	,
cord-332109-ont0tqpn	152	7	cytotoxicity	cytotoxicity	NN
cord-332109-ont0tqpn	152	8	,	,	,
cord-332109-ont0tqpn	152	9	and	and	CC
cord-332109-ont0tqpn	152	10	T	T	NNP
cord-332109-ont0tqpn	152	11	cell	cell	NN
cord-332109-ont0tqpn	152	12	-	-	HYPH
cord-332109-ont0tqpn	152	13	mediated	mediate	VBN
cord-332109-ont0tqpn	152	14	immune	immune	JJ
cord-332109-ont0tqpn	152	15	responses	response	NNS
cord-332109-ont0tqpn	152	16	,	,	,
cord-332109-ont0tqpn	152	17	and	and	CC
cord-332109-ont0tqpn	152	18	is	be	VBZ
cord-332109-ont0tqpn	152	19	linked	link	VBN
cord-332109-ont0tqpn	152	20	to	to	IN
cord-332109-ont0tqpn	152	21	higher	high	JJR
cord-332109-ont0tqpn	152	22	incidences	incidence	NNS
cord-332109-ont0tqpn	152	23	of	of	IN
cord-332109-ont0tqpn	152	24	pathogen	pathogen	NN
cord-332109-ont0tqpn	152	25	infections	infection	NNS
cord-332109-ont0tqpn	152	26	,	,	,
cord-332109-ont0tqpn	152	27	slowed	slow	VBD
cord-332109-ont0tqpn	152	28	recovery	recovery	NN
cord-332109-ont0tqpn	152	29	,	,	,
cord-332109-ont0tqpn	152	30	and	and	CC
cord-332109-ont0tqpn	152	31	severe	severe	JJ
cord-332109-ont0tqpn	152	32	disease	disease	NN
cord-332109-ont0tqpn	152	33	progression	progression	NN
cord-332109-ont0tqpn	152	34	in	in	IN
cord-332109-ont0tqpn	152	35	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	152	36	.	.	.
cord-332109-ont0tqpn	153	1	Bidirectional	bidirectional	JJ
cord-332109-ont0tqpn	153	2	communication	communication	NN
cord-332109-ont0tqpn	153	3	between	between	IN
cord-332109-ont0tqpn	153	4	the	the	DT
cord-332109-ont0tqpn	153	5	brain	brain	NN
cord-332109-ont0tqpn	153	6	and	and	CC
cord-332109-ont0tqpn	153	7	the	the	DT
cord-332109-ont0tqpn	153	8	immune	immune	JJ
cord-332109-ont0tqpn	153	9	system	system	NN
cord-332109-ont0tqpn	153	10	.	.	.
cord-332109-ont0tqpn	154	1	The	the	DT
cord-332109-ont0tqpn	154	2	HPA	HPA	NNP
cord-332109-ont0tqpn	154	3	axis	axis	NN
cord-332109-ont0tqpn	154	4	:	:	:
cord-332109-ont0tqpn	154	5	upon	upon	IN
cord-332109-ont0tqpn	154	6	activation	activation	NN
cord-332109-ont0tqpn	154	7	(	(	-LRB-
cord-332109-ont0tqpn	154	8	cytokines	cytokine	NNS
cord-332109-ont0tqpn	154	9	,	,	,
cord-332109-ont0tqpn	154	10	pathogens	pathogen	NNS
cord-332109-ont0tqpn	154	11	,	,	,
cord-332109-ont0tqpn	154	12	etc	etc	FW
cord-332109-ont0tqpn	154	13	.	.	.
cord-332109-ont0tqpn	154	14	)	)	-RRB-
cord-332109-ont0tqpn	155	1	,	,	,
cord-332109-ont0tqpn	155	2	the	the	DT
cord-332109-ont0tqpn	155	3	hypothalamus	hypothalamus	NN
cord-332109-ont0tqpn	155	4	in	in	IN
cord-332109-ont0tqpn	155	5	the	the	DT
cord-332109-ont0tqpn	155	6	brain	brain	NN
cord-332109-ont0tqpn	155	7	produces	produce	VBZ
cord-332109-ont0tqpn	155	8	CRH	CRH	NNP
cord-332109-ont0tqpn	155	9	and	and	CC
cord-332109-ont0tqpn	155	10	AVP	AVP	NNP
cord-332109-ont0tqpn	155	11	,	,	,
cord-332109-ont0tqpn	155	12	activating	activate	VBG
cord-332109-ont0tqpn	155	13	anterior	anterior	JJ
cord-332109-ont0tqpn	155	14	pituitary	pituitary	NN
cord-332109-ont0tqpn	155	15	,	,	,
cord-332109-ont0tqpn	155	16	which	which	WDT
cord-332109-ont0tqpn	155	17	secretes	secrete	VBZ
cord-332109-ont0tqpn	155	18	ACTH	ACTH	NNP
cord-332109-ont0tqpn	155	19	.	.	.
cord-332109-ont0tqpn	156	1	ACTH	ACTH	NNP
cord-332109-ont0tqpn	156	2	circulates	circulate	VBZ
cord-332109-ont0tqpn	156	3	with	with	IN
cord-332109-ont0tqpn	156	4	general	general	JJ
cord-332109-ont0tqpn	156	5	blood	blood	NN
cord-332109-ont0tqpn	156	6	stream	stream	NN
cord-332109-ont0tqpn	156	7	to	to	TO
cord-332109-ont0tqpn	156	8	reach	reach	VB
cord-332109-ont0tqpn	156	9	adrenal	adrenal	JJ
cord-332109-ont0tqpn	156	10	gland	gland	NN
cord-332109-ont0tqpn	156	11	,	,	,
cord-332109-ont0tqpn	156	12	which	which	WDT
cord-332109-ont0tqpn	156	13	synthesizes	synthesize	VBZ
cord-332109-ont0tqpn	156	14	the	the	DT
cord-332109-ont0tqpn	156	15	anti	anti	JJ
cord-332109-ont0tqpn	156	16	-	-	JJ
cord-332109-ont0tqpn	156	17	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	156	18	molecule	molecule	NN
cord-332109-ont0tqpn	156	19	,	,	,
cord-332109-ont0tqpn	156	20	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	156	21	.	.	.
cord-332109-ont0tqpn	157	1	Glucocorticoids	Glucocorticoids	NNP
cord-332109-ont0tqpn	157	2	suppress	suppress	VBP
cord-332109-ont0tqpn	157	3	the	the	DT
cord-332109-ont0tqpn	157	4	immune	immune	JJ
cord-332109-ont0tqpn	157	5	system	system	NN
cord-332109-ont0tqpn	157	6	and	and	CC
cord-332109-ont0tqpn	157	7	the	the	DT
cord-332109-ont0tqpn	157	8	expression	expression	NN
cord-332109-ont0tqpn	157	9	of	of	IN
cord-332109-ont0tqpn	157	10	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	157	11	cytokines	cytokine	NNS
cord-332109-ont0tqpn	157	12	,	,	,
cord-332109-ont0tqpn	157	13	which	which	WDT
cord-332109-ont0tqpn	157	14	concludes	conclude	VBZ
cord-332109-ont0tqpn	157	15	the	the	DT
cord-332109-ont0tqpn	157	16	negative	negative	JJ
cord-332109-ont0tqpn	157	17	feedback	feedback	NN
cord-332109-ont0tqpn	157	18	and	and	CC
cord-332109-ont0tqpn	157	19	turns	turn	VBZ
cord-332109-ont0tqpn	157	20	off	off	RP
cord-332109-ont0tqpn	157	21	the	the	DT
cord-332109-ont0tqpn	157	22	HPA	HPA	NNP
cord-332109-ont0tqpn	157	23	axis	axis	NN
cord-332109-ont0tqpn	157	24	.	.	.
cord-332109-ont0tqpn	158	1	Glucocorticoids	Glucocorticoids	NNP
cord-332109-ont0tqpn	158	2	suppress	suppress	VBP
cord-332109-ont0tqpn	158	3	the	the	DT
cord-332109-ont0tqpn	158	4	activities	activity	NNS
cord-332109-ont0tqpn	158	5	of	of	IN
cord-332109-ont0tqpn	158	6	various	various	JJ
cord-332109-ont0tqpn	158	7	immune	immune	JJ
cord-332109-ont0tqpn	158	8	cells	cell	NNS
cord-332109-ont0tqpn	158	9	,	,	,
cord-332109-ont0tqpn	158	10	including	include	VBG
cord-332109-ont0tqpn	158	11	macrophages	macrophage	NNS
cord-332109-ont0tqpn	158	12	,	,	,
cord-332109-ont0tqpn	158	13	dendritic	dendritic	JJ
cord-332109-ont0tqpn	158	14	cells	cell	NNS
cord-332109-ont0tqpn	158	15	,	,	,
cord-332109-ont0tqpn	158	16	and	and	CC
cord-332109-ont0tqpn	158	17	T	t	NN
cord-332109-ont0tqpn	158	18	cells	cell	NNS
cord-332109-ont0tqpn	158	19	,	,	,
cord-332109-ont0tqpn	158	20	which	which	WDT
cord-332109-ont0tqpn	158	21	are	be	VBP
cord-332109-ont0tqpn	158	22	responsible	responsible	JJ
cord-332109-ont0tqpn	158	23	for	for	IN
cord-332109-ont0tqpn	158	24	cytokine	cytokine	NN
cord-332109-ont0tqpn	158	25	release	release	NN
cord-332109-ont0tqpn	158	26	.	.	.
cord-332109-ont0tqpn	159	1	The	the	DT
cord-332109-ont0tqpn	159	2	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	159	3	also	also	RB
cord-332109-ont0tqpn	159	4	involves	involve	VBZ
cord-332109-ont0tqpn	159	5	inhibition	inhibition	NN
cord-332109-ont0tqpn	159	6	of	of	IN
cord-332109-ont0tqpn	159	7	NK	NK	NNP
cord-332109-ont0tqpn	159	8	cells	cell	NNS
cord-332109-ont0tqpn	159	9	,	,	,
cord-332109-ont0tqpn	159	10	B	b	NN
cord-332109-ont0tqpn	159	11	cells	cell	NNS
cord-332109-ont0tqpn	159	12	,	,	,
cord-332109-ont0tqpn	159	13	and	and	CC
cord-332109-ont0tqpn	159	14	T	t	NN
cord-332109-ont0tqpn	159	15	cells	cell	NNS
cord-332109-ont0tqpn	159	16	for	for	IN
cord-332109-ont0tqpn	159	17	reduced	reduce	VBN
cord-332109-ont0tqpn	159	18	cytotoxicity	cytotoxicity	NN
cord-332109-ont0tqpn	159	19	,	,	,
cord-332109-ont0tqpn	159	20	antibody	antibody	NN
cord-332109-ont0tqpn	159	21	production	production	NN
cord-332109-ont0tqpn	159	22	,	,	,
cord-332109-ont0tqpn	159	23	and	and	CC
cord-332109-ont0tqpn	159	24	T	T	NNP
cord-332109-ont0tqpn	159	25	cell	cell	NN
cord-332109-ont0tqpn	159	26	-	-	HYPH
cord-332109-ont0tqpn	159	27	mediated	mediate	VBN
cord-332109-ont0tqpn	159	28	immune	immune	JJ
cord-332109-ont0tqpn	159	29	responses	response	NNS
cord-332109-ont0tqpn	159	30	.	.	.
cord-332109-ont0tqpn	160	1	Substances	substance	NNS
cord-332109-ont0tqpn	160	2	of	of	IN
cord-332109-ont0tqpn	160	3	abuse	abuse	NN
cord-332109-ont0tqpn	160	4	alter	alter	VBP
cord-332109-ont0tqpn	160	5	the	the	DT
cord-332109-ont0tqpn	160	6	HPA	HPA	NNP
cord-332109-ont0tqpn	160	7	axis	axis	NN
cord-332109-ont0tqpn	160	8	.	.	.
cord-332109-ont0tqpn	161	1	Excessive	excessive	JJ
cord-332109-ont0tqpn	161	2	production	production	NN
cord-332109-ont0tqpn	161	3	of	of	IN
cord-332109-ont0tqpn	161	4	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	161	5	suppresses	suppress	VBZ
cord-332109-ont0tqpn	161	6	immune	immune	JJ
cord-332109-ont0tqpn	161	7	responses	response	NNS
cord-332109-ont0tqpn	161	8	to	to	IN
cord-332109-ont0tqpn	161	9	viral	viral	JJ
cord-332109-ont0tqpn	161	10	infection	infection	NN
cord-332109-ont0tqpn	161	11	,	,	,
cord-332109-ont0tqpn	161	12	leading	lead	VBG
cord-332109-ont0tqpn	161	13	to	to	IN
cord-332109-ont0tqpn	161	14	high	high	JJ
cord-332109-ont0tqpn	161	15	incidences	incidence	NNS
cord-332109-ont0tqpn	161	16	of	of	IN
cord-332109-ont0tqpn	161	17	infection	infection	NN
cord-332109-ont0tqpn	161	18	and	and	CC
cord-332109-ont0tqpn	161	19	severe	severe	JJ
cord-332109-ont0tqpn	161	20	infection	infection	NN
cord-332109-ont0tqpn	161	21	in	in	IN
cord-332109-ont0tqpn	161	22	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	161	23	.	.	.
cord-332109-ont0tqpn	162	1	Arrows	arrow	NNS
cord-332109-ont0tqpn	162	2	indicate	indicate	VBP
cord-332109-ont0tqpn	162	3	stimulation	stimulation	NN
cord-332109-ont0tqpn	162	4	;	;	,
cord-332109-ont0tqpn	162	5	blunted	blunted	JJ
cord-332109-ont0tqpn	162	6	arrows	arrow	NNS
cord-332109-ont0tqpn	162	7	indicate	indicate	VBP
cord-332109-ont0tqpn	162	8	inhibition	inhibition	NN
cord-332109-ont0tqpn	162	9	.	.	.
cord-332109-ont0tqpn	163	1	For	for	IN
cord-332109-ont0tqpn	163	2	individuals	individual	NNS
cord-332109-ont0tqpn	163	3	with	with	IN
cord-332109-ont0tqpn	163	4	SUDs	sud	NNS
cord-332109-ont0tqpn	163	5	,	,	,
cord-332109-ont0tqpn	163	6	both	both	CC
cord-332109-ont0tqpn	163	7	the	the	DT
cord-332109-ont0tqpn	163	8	infection	infection	NN
cord-332109-ont0tqpn	163	9	of	of	IN
cord-332109-ont0tqpn	163	10	vascular	vascular	JJ
cord-332109-ont0tqpn	163	11	endothelial	endothelial	JJ
cord-332109-ont0tqpn	163	12	cells	cell	NNS
cord-332109-ont0tqpn	163	13	and	and	CC
cord-332109-ont0tqpn	163	14	the	the	DT
cord-332109-ont0tqpn	163	15	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	163	16	immune	immune	JJ
cord-332109-ont0tqpn	163	17	responses	response	NNS
cord-332109-ont0tqpn	163	18	of	of	IN
cord-332109-ont0tqpn	163	19	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	163	20	could	could	MD
cord-332109-ont0tqpn	163	21	pose	pose	VB
cord-332109-ont0tqpn	163	22	severe	severe	JJ
cord-332109-ont0tqpn	163	23	risks	risk	NNS
cord-332109-ont0tqpn	163	24	.	.	.
cord-332109-ont0tqpn	164	1	It	-PRON-	PRP
cord-332109-ont0tqpn	164	2	has	have	VBZ
cord-332109-ont0tqpn	164	3	been	be	VBN
cord-332109-ont0tqpn	164	4	well	well	RB
cord-332109-ont0tqpn	164	5	studied	study	VBN
cord-332109-ont0tqpn	164	6	that	that	IN
cord-332109-ont0tqpn	164	7	substances	substance	NNS
cord-332109-ont0tqpn	164	8	of	of	IN
cord-332109-ont0tqpn	164	9	abuse	abuse	NN
cord-332109-ont0tqpn	164	10	can	can	MD
cord-332109-ont0tqpn	164	11	cause	cause	VB
cord-332109-ont0tqpn	164	12	irreversible	irreversible	JJ
cord-332109-ont0tqpn	164	13	BBB	BBB	NNP
cord-332109-ont0tqpn	164	14	damage	damage	NN
cord-332109-ont0tqpn	164	15	[	[	-LRB-
cord-332109-ont0tqpn	164	16	78	78	CD
cord-332109-ont0tqpn	164	17	]	]	-RRB-
cord-332109-ont0tqpn	164	18	and	and	CC
cord-332109-ont0tqpn	164	19	impair	impair	VB
cord-332109-ont0tqpn	164	20	the	the	DT
cord-332109-ont0tqpn	164	21	HPA	HPA	NNP
cord-332109-ont0tqpn	164	22	axis	axis	NN
cord-332109-ont0tqpn	164	23	and	and	CC
cord-332109-ont0tqpn	164	24	immune	immune	JJ
cord-332109-ont0tqpn	164	25	responses	response	NNS
cord-332109-ont0tqpn	164	26	[	[	-LRB-
cord-332109-ont0tqpn	164	27	75	75	CD
cord-332109-ont0tqpn	164	28	]	]	-RRB-
cord-332109-ont0tqpn	164	29	.	.	.
cord-332109-ont0tqpn	165	1	To	to	TO
cord-332109-ont0tqpn	165	2	understand	understand	VB
cord-332109-ont0tqpn	165	3	the	the	DT
cord-332109-ont0tqpn	165	4	vulnerabilities	vulnerability	NNS
cord-332109-ont0tqpn	165	5	of	of	IN
cord-332109-ont0tqpn	165	6	SUDs	sud	NNS
cord-332109-ont0tqpn	165	7	in	in	IN
cord-332109-ont0tqpn	165	8	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	165	9	infection	infection	NN
cord-332109-ont0tqpn	165	10	at	at	IN
cord-332109-ont0tqpn	165	11	the	the	DT
cord-332109-ont0tqpn	165	12	molecular	molecular	JJ
cord-332109-ont0tqpn	165	13	level	level	NN
cord-332109-ont0tqpn	165	14	,	,	,
cord-332109-ont0tqpn	165	15	we	-PRON-	PRP
cord-332109-ont0tqpn	165	16	will	will	MD
cord-332109-ont0tqpn	165	17	examine	examine	VB
cord-332109-ont0tqpn	165	18	the	the	DT
cord-332109-ont0tqpn	165	19	brain	brain	NN
cord-332109-ont0tqpn	165	20	-	-	HYPH
cord-332109-ont0tqpn	165	21	immune	immune	JJ
cord-332109-ont0tqpn	165	22	interactions	interaction	NNS
cord-332109-ont0tqpn	165	23	and	and	CC
cord-332109-ont0tqpn	165	24	the	the	DT
cord-332109-ont0tqpn	165	25	HPA	HPA	NNP
cord-332109-ont0tqpn	165	26	axis	axis	NN
cord-332109-ont0tqpn	165	27	attenuation	attenuation	NN
cord-332109-ont0tqpn	165	28	,	,	,
cord-332109-ont0tqpn	165	29	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	165	30	,	,	,
cord-332109-ont0tqpn	165	31	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	165	32	,	,	,
cord-332109-ont0tqpn	165	33	and	and	CC
cord-332109-ont0tqpn	165	34	BBB	BBB	NNP
cord-332109-ont0tqpn	165	35	impairment	impairment	NN
cord-332109-ont0tqpn	165	36	induced	induce	VBN
cord-332109-ont0tqpn	165	37	by	by	IN
cord-332109-ont0tqpn	165	38	most	most	RBS
cord-332109-ont0tqpn	165	39	commonly	commonly	RB
cord-332109-ont0tqpn	165	40	abused	abuse	VBN
cord-332109-ont0tqpn	165	41	substances	substance	NNS
cord-332109-ont0tqpn	165	42	in	in	IN
cord-332109-ont0tqpn	165	43	the	the	DT
cord-332109-ont0tqpn	165	44	comorbidity	comorbidity	NN
cord-332109-ont0tqpn	165	45	of	of	IN
cord-332109-ont0tqpn	165	46	COVID-19	covid-19	NN
cord-332109-ont0tqpn	165	47	.	.	.
cord-332109-ont0tqpn	166	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	166	2	is	be	VBZ
cord-332109-ont0tqpn	166	3	available	available	JJ
cord-332109-ont0tqpn	166	4	in	in	IN
cord-332109-ont0tqpn	166	5	the	the	DT
cord-332109-ont0tqpn	166	6	form	form	NN
cord-332109-ont0tqpn	166	7	of	of	IN
cord-332109-ont0tqpn	166	8	tobacco	tobacco	NN
cord-332109-ont0tqpn	166	9	,	,	,
cord-332109-ont0tqpn	166	10	which	which	WDT
cord-332109-ont0tqpn	166	11	also	also	RB
cord-332109-ont0tqpn	166	12	contains	contain	VBZ
cord-332109-ont0tqpn	166	13	many	many	JJ
cord-332109-ont0tqpn	166	14	other	other	JJ
cord-332109-ont0tqpn	166	15	types	type	NNS
cord-332109-ont0tqpn	166	16	of	of	IN
cord-332109-ont0tqpn	166	17	chemicals	chemical	NNS
cord-332109-ont0tqpn	166	18	.	.	.
cord-332109-ont0tqpn	167	1	Tobacco	tobacco	NN
cord-332109-ont0tqpn	167	2	smoking	smoking	NN
cord-332109-ont0tqpn	167	3	is	be	VBZ
cord-332109-ont0tqpn	167	4	associated	associate	VBN
cord-332109-ont0tqpn	167	5	with	with	IN
cord-332109-ont0tqpn	167	6	arterial	arterial	JJ
cord-332109-ont0tqpn	167	7	thrombosis	thrombosis	NN
cord-332109-ont0tqpn	167	8	and	and	CC
cord-332109-ont0tqpn	167	9	atherosclerosis	atherosclerosis	NN
cord-332109-ont0tqpn	167	10	in	in	IN
cord-332109-ont0tqpn	167	11	the	the	DT
cord-332109-ont0tqpn	167	12	heart	heart	NN
cord-332109-ont0tqpn	167	13	,	,	,
cord-332109-ont0tqpn	167	14	abdomen	abdomen	NN
cord-332109-ont0tqpn	167	15	,	,	,
cord-332109-ont0tqpn	167	16	Figure	figure	NN
cord-332109-ont0tqpn	167	17	3	3	CD
cord-332109-ont0tqpn	167	18	.	.	.
cord-332109-ont0tqpn	168	1	Bidirectional	bidirectional	JJ
cord-332109-ont0tqpn	168	2	communication	communication	NN
cord-332109-ont0tqpn	168	3	between	between	IN
cord-332109-ont0tqpn	168	4	the	the	DT
cord-332109-ont0tqpn	168	5	brain	brain	NN
cord-332109-ont0tqpn	168	6	and	and	CC
cord-332109-ont0tqpn	168	7	the	the	DT
cord-332109-ont0tqpn	168	8	immune	immune	JJ
cord-332109-ont0tqpn	168	9	system	system	NN
cord-332109-ont0tqpn	168	10	.	.	.
cord-332109-ont0tqpn	169	1	The	the	DT
cord-332109-ont0tqpn	169	2	HPA	HPA	NNP
cord-332109-ont0tqpn	169	3	axis	axis	NN
cord-332109-ont0tqpn	169	4	:	:	:
cord-332109-ont0tqpn	169	5	upon	upon	IN
cord-332109-ont0tqpn	169	6	activation	activation	NN
cord-332109-ont0tqpn	169	7	(	(	-LRB-
cord-332109-ont0tqpn	169	8	cytokines	cytokine	NNS
cord-332109-ont0tqpn	169	9	,	,	,
cord-332109-ont0tqpn	169	10	pathogens	pathogen	NNS
cord-332109-ont0tqpn	169	11	,	,	,
cord-332109-ont0tqpn	169	12	etc	etc	FW
cord-332109-ont0tqpn	169	13	.	.	.
cord-332109-ont0tqpn	169	14	)	)	-RRB-
cord-332109-ont0tqpn	170	1	,	,	,
cord-332109-ont0tqpn	170	2	the	the	DT
cord-332109-ont0tqpn	170	3	hypothalamus	hypothalamus	NN
cord-332109-ont0tqpn	170	4	in	in	IN
cord-332109-ont0tqpn	170	5	the	the	DT
cord-332109-ont0tqpn	170	6	brain	brain	NN
cord-332109-ont0tqpn	170	7	produces	produce	VBZ
cord-332109-ont0tqpn	170	8	CRH	CRH	NNP
cord-332109-ont0tqpn	170	9	and	and	CC
cord-332109-ont0tqpn	170	10	AVP	AVP	NNP
cord-332109-ont0tqpn	170	11	,	,	,
cord-332109-ont0tqpn	170	12	activating	activate	VBG
cord-332109-ont0tqpn	170	13	anterior	anterior	JJ
cord-332109-ont0tqpn	170	14	pituitary	pituitary	NN
cord-332109-ont0tqpn	170	15	,	,	,
cord-332109-ont0tqpn	170	16	which	which	WDT
cord-332109-ont0tqpn	170	17	secretes	secrete	VBZ
cord-332109-ont0tqpn	170	18	ACTH	ACTH	NNP
cord-332109-ont0tqpn	170	19	.	.	.
cord-332109-ont0tqpn	171	1	ACTH	ACTH	NNP
cord-332109-ont0tqpn	171	2	circulates	circulate	VBZ
cord-332109-ont0tqpn	171	3	with	with	IN
cord-332109-ont0tqpn	171	4	general	general	JJ
cord-332109-ont0tqpn	171	5	blood	blood	NN
cord-332109-ont0tqpn	171	6	stream	stream	NN
cord-332109-ont0tqpn	171	7	to	to	TO
cord-332109-ont0tqpn	171	8	reach	reach	VB
cord-332109-ont0tqpn	171	9	adrenal	adrenal	JJ
cord-332109-ont0tqpn	171	10	gland	gland	NN
cord-332109-ont0tqpn	171	11	,	,	,
cord-332109-ont0tqpn	171	12	which	which	WDT
cord-332109-ont0tqpn	171	13	synthesizes	synthesize	VBZ
cord-332109-ont0tqpn	171	14	the	the	DT
cord-332109-ont0tqpn	171	15	anti	anti	JJ
cord-332109-ont0tqpn	171	16	-	-	JJ
cord-332109-ont0tqpn	171	17	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	171	18	molecule	molecule	NN
cord-332109-ont0tqpn	171	19	,	,	,
cord-332109-ont0tqpn	171	20	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	171	21	.	.	.
cord-332109-ont0tqpn	172	1	Glucocorticoids	Glucocorticoids	NNP
cord-332109-ont0tqpn	172	2	suppress	suppress	VBP
cord-332109-ont0tqpn	172	3	the	the	DT
cord-332109-ont0tqpn	172	4	immune	immune	JJ
cord-332109-ont0tqpn	172	5	system	system	NN
cord-332109-ont0tqpn	172	6	and	and	CC
cord-332109-ont0tqpn	172	7	the	the	DT
cord-332109-ont0tqpn	172	8	expression	expression	NN
cord-332109-ont0tqpn	172	9	of	of	IN
cord-332109-ont0tqpn	172	10	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	172	11	cytokines	cytokine	NNS
cord-332109-ont0tqpn	172	12	,	,	,
cord-332109-ont0tqpn	172	13	which	which	WDT
cord-332109-ont0tqpn	172	14	concludes	conclude	VBZ
cord-332109-ont0tqpn	172	15	the	the	DT
cord-332109-ont0tqpn	172	16	negative	negative	JJ
cord-332109-ont0tqpn	172	17	feedback	feedback	NN
cord-332109-ont0tqpn	172	18	and	and	CC
cord-332109-ont0tqpn	172	19	turns	turn	VBZ
cord-332109-ont0tqpn	172	20	off	off	RP
cord-332109-ont0tqpn	172	21	the	the	DT
cord-332109-ont0tqpn	172	22	HPA	HPA	NNP
cord-332109-ont0tqpn	172	23	axis	axis	NN
cord-332109-ont0tqpn	172	24	.	.	.
cord-332109-ont0tqpn	173	1	Glucocorticoids	Glucocorticoids	NNP
cord-332109-ont0tqpn	173	2	suppress	suppress	VBP
cord-332109-ont0tqpn	173	3	the	the	DT
cord-332109-ont0tqpn	173	4	activities	activity	NNS
cord-332109-ont0tqpn	173	5	of	of	IN
cord-332109-ont0tqpn	173	6	various	various	JJ
cord-332109-ont0tqpn	173	7	immune	immune	JJ
cord-332109-ont0tqpn	173	8	cells	cell	NNS
cord-332109-ont0tqpn	173	9	,	,	,
cord-332109-ont0tqpn	173	10	including	include	VBG
cord-332109-ont0tqpn	173	11	macrophages	macrophage	NNS
cord-332109-ont0tqpn	173	12	,	,	,
cord-332109-ont0tqpn	173	13	dendritic	dendritic	JJ
cord-332109-ont0tqpn	173	14	cells	cell	NNS
cord-332109-ont0tqpn	173	15	,	,	,
cord-332109-ont0tqpn	173	16	and	and	CC
cord-332109-ont0tqpn	173	17	T	t	NN
cord-332109-ont0tqpn	173	18	cells	cell	NNS
cord-332109-ont0tqpn	173	19	,	,	,
cord-332109-ont0tqpn	173	20	which	which	WDT
cord-332109-ont0tqpn	173	21	are	be	VBP
cord-332109-ont0tqpn	173	22	responsible	responsible	JJ
cord-332109-ont0tqpn	173	23	for	for	IN
cord-332109-ont0tqpn	173	24	cytokine	cytokine	NN
cord-332109-ont0tqpn	173	25	release	release	NN
cord-332109-ont0tqpn	173	26	.	.	.
cord-332109-ont0tqpn	174	1	The	the	DT
cord-332109-ont0tqpn	174	2	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	174	3	also	also	RB
cord-332109-ont0tqpn	174	4	involves	involve	VBZ
cord-332109-ont0tqpn	174	5	inhibition	inhibition	NN
cord-332109-ont0tqpn	174	6	of	of	IN
cord-332109-ont0tqpn	174	7	NK	NK	NNP
cord-332109-ont0tqpn	174	8	cells	cell	NNS
cord-332109-ont0tqpn	174	9	,	,	,
cord-332109-ont0tqpn	174	10	B	b	NN
cord-332109-ont0tqpn	174	11	cells	cell	NNS
cord-332109-ont0tqpn	174	12	,	,	,
cord-332109-ont0tqpn	174	13	and	and	CC
cord-332109-ont0tqpn	174	14	T	t	NN
cord-332109-ont0tqpn	174	15	cells	cell	NNS
cord-332109-ont0tqpn	174	16	for	for	IN
cord-332109-ont0tqpn	174	17	reduced	reduce	VBN
cord-332109-ont0tqpn	174	18	cytotoxicity	cytotoxicity	NN
cord-332109-ont0tqpn	174	19	,	,	,
cord-332109-ont0tqpn	174	20	antibody	antibody	NN
cord-332109-ont0tqpn	174	21	production	production	NN
cord-332109-ont0tqpn	174	22	,	,	,
cord-332109-ont0tqpn	174	23	and	and	CC
cord-332109-ont0tqpn	174	24	T	T	NNP
cord-332109-ont0tqpn	174	25	cell	cell	NN
cord-332109-ont0tqpn	174	26	-	-	HYPH
cord-332109-ont0tqpn	174	27	mediated	mediate	VBN
cord-332109-ont0tqpn	174	28	immune	immune	JJ
cord-332109-ont0tqpn	174	29	responses	response	NNS
cord-332109-ont0tqpn	174	30	.	.	.
cord-332109-ont0tqpn	175	1	Substances	substance	NNS
cord-332109-ont0tqpn	175	2	of	of	IN
cord-332109-ont0tqpn	175	3	abuse	abuse	NN
cord-332109-ont0tqpn	175	4	alter	alter	VBP
cord-332109-ont0tqpn	175	5	the	the	DT
cord-332109-ont0tqpn	175	6	HPA	HPA	NNP
cord-332109-ont0tqpn	175	7	axis	axis	NN
cord-332109-ont0tqpn	175	8	.	.	.
cord-332109-ont0tqpn	176	1	Excessive	excessive	JJ
cord-332109-ont0tqpn	176	2	production	production	NN
cord-332109-ont0tqpn	176	3	of	of	IN
cord-332109-ont0tqpn	176	4	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	176	5	suppresses	suppress	VBZ
cord-332109-ont0tqpn	176	6	immune	immune	JJ
cord-332109-ont0tqpn	176	7	responses	response	NNS
cord-332109-ont0tqpn	176	8	to	to	IN
cord-332109-ont0tqpn	176	9	viral	viral	JJ
cord-332109-ont0tqpn	176	10	infection	infection	NN
cord-332109-ont0tqpn	176	11	,	,	,
cord-332109-ont0tqpn	176	12	leading	lead	VBG
cord-332109-ont0tqpn	176	13	to	to	IN
cord-332109-ont0tqpn	176	14	high	high	JJ
cord-332109-ont0tqpn	176	15	incidences	incidence	NNS
cord-332109-ont0tqpn	176	16	of	of	IN
cord-332109-ont0tqpn	176	17	infection	infection	NN
cord-332109-ont0tqpn	176	18	and	and	CC
cord-332109-ont0tqpn	176	19	severe	severe	JJ
cord-332109-ont0tqpn	176	20	infection	infection	NN
cord-332109-ont0tqpn	176	21	in	in	IN
cord-332109-ont0tqpn	176	22	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	176	23	.	.	.
cord-332109-ont0tqpn	177	1	Arrows	arrow	NNS
cord-332109-ont0tqpn	177	2	indicate	indicate	VBP
cord-332109-ont0tqpn	177	3	stimulation	stimulation	NN
cord-332109-ont0tqpn	177	4	;	;	,
cord-332109-ont0tqpn	177	5	blunted	blunted	JJ
cord-332109-ont0tqpn	177	6	arrows	arrow	NNS
cord-332109-ont0tqpn	177	7	indicate	indicate	VBP
cord-332109-ont0tqpn	177	8	inhibition	inhibition	NN
cord-332109-ont0tqpn	177	9	.	.	.
cord-332109-ont0tqpn	178	1	For	for	IN
cord-332109-ont0tqpn	178	2	individuals	individual	NNS
cord-332109-ont0tqpn	178	3	with	with	IN
cord-332109-ont0tqpn	178	4	SUDs	sud	NNS
cord-332109-ont0tqpn	178	5	,	,	,
cord-332109-ont0tqpn	178	6	both	both	CC
cord-332109-ont0tqpn	178	7	the	the	DT
cord-332109-ont0tqpn	178	8	infection	infection	NN
cord-332109-ont0tqpn	178	9	of	of	IN
cord-332109-ont0tqpn	178	10	vascular	vascular	JJ
cord-332109-ont0tqpn	178	11	endothelial	endothelial	JJ
cord-332109-ont0tqpn	178	12	cells	cell	NNS
cord-332109-ont0tqpn	178	13	and	and	CC
cord-332109-ont0tqpn	178	14	the	the	DT
cord-332109-ont0tqpn	178	15	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	178	16	immune	immune	JJ
cord-332109-ont0tqpn	178	17	responses	response	NNS
cord-332109-ont0tqpn	178	18	of	of	IN
cord-332109-ont0tqpn	178	19	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	178	20	could	could	MD
cord-332109-ont0tqpn	178	21	pose	pose	VB
cord-332109-ont0tqpn	178	22	severe	severe	JJ
cord-332109-ont0tqpn	178	23	risks	risk	NNS
cord-332109-ont0tqpn	178	24	.	.	.
cord-332109-ont0tqpn	179	1	It	-PRON-	PRP
cord-332109-ont0tqpn	179	2	has	have	VBZ
cord-332109-ont0tqpn	179	3	been	be	VBN
cord-332109-ont0tqpn	179	4	well	well	RB
cord-332109-ont0tqpn	179	5	studied	study	VBN
cord-332109-ont0tqpn	179	6	that	that	IN
cord-332109-ont0tqpn	179	7	substances	substance	NNS
cord-332109-ont0tqpn	179	8	of	of	IN
cord-332109-ont0tqpn	179	9	abuse	abuse	NN
cord-332109-ont0tqpn	179	10	can	can	MD
cord-332109-ont0tqpn	179	11	cause	cause	VB
cord-332109-ont0tqpn	179	12	irreversible	irreversible	JJ
cord-332109-ont0tqpn	179	13	BBB	BBB	NNP
cord-332109-ont0tqpn	179	14	damage	damage	NN
cord-332109-ont0tqpn	179	15	[	[	-LRB-
cord-332109-ont0tqpn	179	16	78	78	CD
cord-332109-ont0tqpn	179	17	]	]	-RRB-
cord-332109-ont0tqpn	179	18	and	and	CC
cord-332109-ont0tqpn	179	19	impair	impair	VB
cord-332109-ont0tqpn	179	20	the	the	DT
cord-332109-ont0tqpn	179	21	HPA	HPA	NNP
cord-332109-ont0tqpn	179	22	axis	axis	NN
cord-332109-ont0tqpn	179	23	and	and	CC
cord-332109-ont0tqpn	179	24	immune	immune	JJ
cord-332109-ont0tqpn	179	25	responses	response	NNS
cord-332109-ont0tqpn	179	26	[	[	-LRB-
cord-332109-ont0tqpn	179	27	75	75	CD
cord-332109-ont0tqpn	179	28	]	]	-RRB-
cord-332109-ont0tqpn	179	29	.	.	.
cord-332109-ont0tqpn	180	1	To	to	TO
cord-332109-ont0tqpn	180	2	understand	understand	VB
cord-332109-ont0tqpn	180	3	the	the	DT
cord-332109-ont0tqpn	180	4	vulnerabilities	vulnerability	NNS
cord-332109-ont0tqpn	180	5	of	of	IN
cord-332109-ont0tqpn	180	6	SUDs	sud	NNS
cord-332109-ont0tqpn	180	7	in	in	IN
cord-332109-ont0tqpn	180	8	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	180	9	infection	infection	NN
cord-332109-ont0tqpn	180	10	at	at	IN
cord-332109-ont0tqpn	180	11	the	the	DT
cord-332109-ont0tqpn	180	12	molecular	molecular	JJ
cord-332109-ont0tqpn	180	13	level	level	NN
cord-332109-ont0tqpn	180	14	,	,	,
cord-332109-ont0tqpn	180	15	we	-PRON-	PRP
cord-332109-ont0tqpn	180	16	will	will	MD
cord-332109-ont0tqpn	180	17	examine	examine	VB
cord-332109-ont0tqpn	180	18	the	the	DT
cord-332109-ont0tqpn	180	19	brain	brain	NN
cord-332109-ont0tqpn	180	20	-	-	HYPH
cord-332109-ont0tqpn	180	21	immune	immune	JJ
cord-332109-ont0tqpn	180	22	interactions	interaction	NNS
cord-332109-ont0tqpn	180	23	and	and	CC
cord-332109-ont0tqpn	180	24	the	the	DT
cord-332109-ont0tqpn	180	25	HPA	HPA	NNP
cord-332109-ont0tqpn	180	26	axis	axis	NN
cord-332109-ont0tqpn	180	27	attenuation	attenuation	NN
cord-332109-ont0tqpn	180	28	,	,	,
cord-332109-ont0tqpn	180	29	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	180	30	,	,	,
cord-332109-ont0tqpn	180	31	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	180	32	,	,	,
cord-332109-ont0tqpn	180	33	and	and	CC
cord-332109-ont0tqpn	180	34	BBB	BBB	NNP
cord-332109-ont0tqpn	180	35	impairment	impairment	NN
cord-332109-ont0tqpn	180	36	induced	induce	VBN
cord-332109-ont0tqpn	180	37	by	by	IN
cord-332109-ont0tqpn	180	38	most	most	RBS
cord-332109-ont0tqpn	180	39	commonly	commonly	RB
cord-332109-ont0tqpn	180	40	abused	abuse	VBN
cord-332109-ont0tqpn	180	41	substances	substance	NNS
cord-332109-ont0tqpn	180	42	in	in	IN
cord-332109-ont0tqpn	180	43	the	the	DT
cord-332109-ont0tqpn	180	44	comorbidity	comorbidity	NN
cord-332109-ont0tqpn	180	45	of	of	IN
cord-332109-ont0tqpn	180	46	COVID-19	covid-19	NN
cord-332109-ont0tqpn	180	47	.	.	.
cord-332109-ont0tqpn	181	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	181	2	is	be	VBZ
cord-332109-ont0tqpn	181	3	available	available	JJ
cord-332109-ont0tqpn	181	4	in	in	IN
cord-332109-ont0tqpn	181	5	the	the	DT
cord-332109-ont0tqpn	181	6	form	form	NN
cord-332109-ont0tqpn	181	7	of	of	IN
cord-332109-ont0tqpn	181	8	tobacco	tobacco	NN
cord-332109-ont0tqpn	181	9	,	,	,
cord-332109-ont0tqpn	181	10	which	which	WDT
cord-332109-ont0tqpn	181	11	also	also	RB
cord-332109-ont0tqpn	181	12	contains	contain	VBZ
cord-332109-ont0tqpn	181	13	many	many	JJ
cord-332109-ont0tqpn	181	14	other	other	JJ
cord-332109-ont0tqpn	181	15	types	type	NNS
cord-332109-ont0tqpn	181	16	of	of	IN
cord-332109-ont0tqpn	181	17	chemicals	chemical	NNS
cord-332109-ont0tqpn	181	18	.	.	.
cord-332109-ont0tqpn	182	1	Tobacco	tobacco	NN
cord-332109-ont0tqpn	182	2	smoking	smoking	NN
cord-332109-ont0tqpn	182	3	is	be	VBZ
cord-332109-ont0tqpn	182	4	associated	associate	VBN
cord-332109-ont0tqpn	182	5	with	with	IN
cord-332109-ont0tqpn	182	6	arterial	arterial	JJ
cord-332109-ont0tqpn	182	7	thrombosis	thrombosis	NN
cord-332109-ont0tqpn	182	8	and	and	CC
cord-332109-ont0tqpn	182	9	atherosclerosis	atherosclerosis	NN
cord-332109-ont0tqpn	182	10	in	in	IN
cord-332109-ont0tqpn	182	11	the	the	DT
cord-332109-ont0tqpn	182	12	heart	heart	NN
cord-332109-ont0tqpn	182	13	,	,	,
cord-332109-ont0tqpn	182	14	abdomen	abdomen	NN
cord-332109-ont0tqpn	182	15	,	,	,
cord-332109-ont0tqpn	182	16	and	and	CC
cord-332109-ont0tqpn	182	17	neck	neck	NN
cord-332109-ont0tqpn	182	18	[	[	-LRB-
cord-332109-ont0tqpn	182	19	79	79	CD
cord-332109-ont0tqpn	182	20	]	]	-RRB-
cord-332109-ont0tqpn	182	21	,	,	,
cord-332109-ont0tqpn	182	22	and	and	CC
cord-332109-ont0tqpn	182	23	is	be	VBZ
cord-332109-ont0tqpn	182	24	associated	associate	VBN
cord-332109-ont0tqpn	182	25	with	with	IN
cord-332109-ont0tqpn	182	26	increased	increase	VBN
cord-332109-ont0tqpn	182	27	risk	risk	NN
cord-332109-ont0tqpn	182	28	of	of	IN
cord-332109-ont0tqpn	182	29	stroke	stroke	NN
cord-332109-ont0tqpn	182	30	,	,	,
cord-332109-ont0tqpn	182	31	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	182	32	disease	disease	NN
cord-332109-ont0tqpn	182	33	,	,	,
cord-332109-ont0tqpn	182	34	and	and	CC
cord-332109-ont0tqpn	182	35	emphysema	emphysema	NN
cord-332109-ont0tqpn	182	36	[	[	-LRB-
cord-332109-ont0tqpn	182	37	80	80	CD
cord-332109-ont0tqpn	182	38	]	]	-RRB-
cord-332109-ont0tqpn	182	39	.	.	.
cord-332109-ont0tqpn	183	1	As	as	IN
cord-332109-ont0tqpn	183	2	nicotine	nicotine	NN
cord-332109-ont0tqpn	183	3	damages	damage	NNS
cord-332109-ont0tqpn	183	4	the	the	DT
cord-332109-ont0tqpn	183	5	lung	lung	NN
cord-332109-ont0tqpn	183	6	directly	directly	RB
cord-332109-ont0tqpn	183	7	,	,	,
cord-332109-ont0tqpn	183	8	smoking	smoking	NN
cord-332109-ont0tqpn	183	9	is	be	VBZ
cord-332109-ont0tqpn	183	10	one	one	CD
cord-332109-ont0tqpn	183	11	of	of	IN
cord-332109-ont0tqpn	183	12	the	the	DT
cord-332109-ont0tqpn	183	13	leading	lead	VBG
cord-332109-ont0tqpn	183	14	causes	cause	NNS
cord-332109-ont0tqpn	183	15	of	of	IN
cord-332109-ont0tqpn	183	16	COPD	COPD	NNP
cord-332109-ont0tqpn	183	17	.	.	.
cord-332109-ont0tqpn	184	1	Smokers	smoker	NNS
cord-332109-ont0tqpn	184	2	and	and	CC
cord-332109-ont0tqpn	184	3	COPD	COPD	NNP
cord-332109-ont0tqpn	184	4	patients	patient	NNS
cord-332109-ont0tqpn	184	5	are	be	VBP
cord-332109-ont0tqpn	184	6	of	of	IN
cord-332109-ont0tqpn	184	7	high	high	JJ
cord-332109-ont0tqpn	184	8	risk	risk	NN
cord-332109-ont0tqpn	184	9	in	in	IN
cord-332109-ont0tqpn	184	10	developing	develop	VBG
cord-332109-ont0tqpn	184	11	severe	severe	JJ
cord-332109-ont0tqpn	184	12	disease	disease	NN
cord-332109-ont0tqpn	184	13	and	and	CC
cord-332109-ont0tqpn	184	14	have	have	VB
cord-332109-ont0tqpn	184	15	a	a	DT
cord-332109-ont0tqpn	184	16	higher	high	JJR
cord-332109-ont0tqpn	184	17	mortality	mortality	NN
cord-332109-ont0tqpn	184	18	rate	rate	NN
cord-332109-ont0tqpn	184	19	in	in	IN
cord-332109-ont0tqpn	184	20	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	184	21	[	[	-LRB-
cord-332109-ont0tqpn	184	22	13	13	CD
cord-332109-ont0tqpn	184	23	]	]	-RRB-
cord-332109-ont0tqpn	184	24	.	.	.
cord-332109-ont0tqpn	185	1	Smoking	smoking	NN
cord-332109-ont0tqpn	185	2	can	can	MD
cord-332109-ont0tqpn	185	3	significantly	significantly	RB
cord-332109-ont0tqpn	185	4	worsen	worsen	VB
cord-332109-ont0tqpn	185	5	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	185	6	progression	progression	NN
cord-332109-ont0tqpn	185	7	,	,	,
cord-332109-ont0tqpn	185	8	with	with	IN
cord-332109-ont0tqpn	185	9	more	more	RBR
cord-332109-ont0tqpn	185	10	critical	critical	JJ
cord-332109-ont0tqpn	185	11	conditions	condition	NNS
cord-332109-ont0tqpn	185	12	and	and	CC
cord-332109-ont0tqpn	185	13	higher	high	JJR
cord-332109-ont0tqpn	185	14	fatality	fatality	NN
cord-332109-ont0tqpn	185	15	[	[	-LRB-
cord-332109-ont0tqpn	185	16	81	81	CD
cord-332109-ont0tqpn	185	17	]	]	-RRB-
cord-332109-ont0tqpn	185	18	.	.	.
cord-332109-ont0tqpn	186	1	Cigarette	cigarette	NN
cord-332109-ont0tqpn	186	2	smoking	smoking	NN
cord-332109-ont0tqpn	186	3	increases	increase	VBZ
cord-332109-ont0tqpn	186	4	the	the	DT
cord-332109-ont0tqpn	186	5	number	number	NN
cord-332109-ont0tqpn	186	6	of	of	IN
cord-332109-ont0tqpn	186	7	alveolar	alveolar	JJ
cord-332109-ont0tqpn	186	8	macrophages	macrophage	NNS
cord-332109-ont0tqpn	186	9	(	(	-LRB-
cord-332109-ont0tqpn	186	10	AMs	AMs	NNP
cord-332109-ont0tqpn	186	11	)	)	-RRB-
cord-332109-ont0tqpn	186	12	,	,	,
cord-332109-ont0tqpn	186	13	the	the	DT
cord-332109-ont0tqpn	186	14	innate	innate	JJ
cord-332109-ont0tqpn	186	15	immune	immune	JJ
cord-332109-ont0tqpn	186	16	cells	cell	NNS
cord-332109-ont0tqpn	186	17	in	in	IN
cord-332109-ont0tqpn	186	18	the	the	DT
cord-332109-ont0tqpn	186	19	lung	lung	NN
cord-332109-ont0tqpn	186	20	by	by	IN
cord-332109-ont0tqpn	186	21	several	several	JJ
cord-332109-ont0tqpn	186	22	fold	fold	NN
cord-332109-ont0tqpn	186	23	.	.	.
cord-332109-ont0tqpn	187	1	These	these	DT
cord-332109-ont0tqpn	187	2	cells	cell	NNS
cord-332109-ont0tqpn	187	3	secrete	secrete	VBP
cord-332109-ont0tqpn	187	4	lysosomal	lysosomal	JJ
cord-332109-ont0tqpn	187	5	enzyme	enzyme	NN
cord-332109-ont0tqpn	187	6	,	,	,
cord-332109-ont0tqpn	187	7	elastase	elastase	NN
cord-332109-ont0tqpn	187	8	,	,	,
cord-332109-ont0tqpn	187	9	which	which	WDT
cord-332109-ont0tqpn	187	10	can	can	MD
cord-332109-ont0tqpn	187	11	damage	damage	VB
cord-332109-ont0tqpn	187	12	connective	connective	JJ
cord-332109-ont0tqpn	187	13	tissue	tissue	NN
cord-332109-ont0tqpn	187	14	and	and	CC
cord-332109-ont0tqpn	187	15	parenchymal	parenchymal	NN
cord-332109-ont0tqpn	187	16	cells	cell	NNS
cord-332109-ont0tqpn	187	17	of	of	IN
cord-332109-ont0tqpn	187	18	the	the	DT
cord-332109-ont0tqpn	187	19	lung	lung	NN
cord-332109-ont0tqpn	187	20	,	,	,
cord-332109-ont0tqpn	187	21	one	one	CD
cord-332109-ont0tqpn	187	22	of	of	IN
cord-332109-ont0tqpn	187	23	the	the	DT
cord-332109-ont0tqpn	187	24	contributors	contributor	NNS
cord-332109-ont0tqpn	187	25	to	to	IN
cord-332109-ont0tqpn	187	26	the	the	DT
cord-332109-ont0tqpn	187	27	COPD	COPD	NNP
cord-332109-ont0tqpn	187	28	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	187	29	[	[	-LRB-
cord-332109-ont0tqpn	187	30	82	82	CD
cord-332109-ont0tqpn	187	31	]	]	-RRB-
cord-332109-ont0tqpn	187	32	.	.	.
cord-332109-ont0tqpn	188	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	188	2	is	be	VBZ
cord-332109-ont0tqpn	188	3	also	also	RB
cord-332109-ont0tqpn	188	4	an	an	DT
cord-332109-ont0tqpn	188	5	important	important	JJ
cord-332109-ont0tqpn	188	6	immune	immune	JJ
cord-332109-ont0tqpn	188	7	modulator	modulator	NN
cord-332109-ont0tqpn	188	8	.	.	.
cord-332109-ont0tqpn	189	1	It	-PRON-	PRP
cord-332109-ont0tqpn	189	2	significantly	significantly	RB
cord-332109-ont0tqpn	189	3	reduces	reduce	VBZ
cord-332109-ont0tqpn	189	4	antibody	antibody	NN
cord-332109-ont0tqpn	189	5	responses	response	NNS
cord-332109-ont0tqpn	189	6	and	and	CC
cord-332109-ont0tqpn	189	7	T	t	NN
cord-332109-ont0tqpn	189	8	-	-	HYPH
cord-332109-ont0tqpn	189	9	cell	cell	NN
cord-332109-ont0tqpn	189	10	proliferation	proliferation	NN
cord-332109-ont0tqpn	189	11	[	[	-LRB-
cord-332109-ont0tqpn	189	12	83	83	CD
cord-332109-ont0tqpn	189	13	]	]	-RRB-
cord-332109-ont0tqpn	189	14	.	.	.
cord-332109-ont0tqpn	190	1	The	the	DT
cord-332109-ont0tqpn	190	2	immune	immune	JJ
cord-332109-ont0tqpn	190	3	suppression	suppression	NN
cord-332109-ont0tqpn	190	4	by	by	IN
cord-332109-ont0tqpn	190	5	nicotine	nicotine	NN
cord-332109-ont0tqpn	190	6	,	,	,
cord-332109-ont0tqpn	190	7	particularly	particularly	RB
cord-332109-ont0tqpn	190	8	the	the	DT
cord-332109-ont0tqpn	190	9	decrease	decrease	NN
cord-332109-ont0tqpn	190	10	in	in	IN
cord-332109-ont0tqpn	190	11	CD8	CD8	NNP
cord-332109-ont0tqpn	190	12	+	+	CC
cord-332109-ont0tqpn	190	13	T	T	NNP
cord-332109-ont0tqpn	190	14	-	-	HYPH
cord-332109-ont0tqpn	190	15	cells	cell	NNS
cord-332109-ont0tqpn	190	16	that	that	WDT
cord-332109-ont0tqpn	190	17	facilitate	facilitate	VBP
cord-332109-ont0tqpn	190	18	the	the	DT
cord-332109-ont0tqpn	190	19	rapid	rapid	JJ
cord-332109-ont0tqpn	190	20	resolution	resolution	NN
cord-332109-ont0tqpn	190	21	of	of	IN
cord-332109-ont0tqpn	190	22	acute	acute	JJ
cord-332109-ont0tqpn	190	23	viral	viral	JJ
cord-332109-ont0tqpn	190	24	infections	infection	NNS
cord-332109-ont0tqpn	190	25	,	,	,
cord-332109-ont0tqpn	190	26	increases	increase	VBZ
cord-332109-ont0tqpn	190	27	the	the	DT
cord-332109-ont0tqpn	190	28	susceptibility	susceptibility	NN
cord-332109-ont0tqpn	190	29	of	of	IN
cord-332109-ont0tqpn	190	30	smokers	smoker	NNS
cord-332109-ont0tqpn	190	31	for	for	IN
cord-332109-ont0tqpn	190	32	viral	viral	JJ
cord-332109-ont0tqpn	190	33	infections	infection	NNS
cord-332109-ont0tqpn	190	34	[	[	-LRB-
cord-332109-ont0tqpn	190	35	84	84	CD
cord-332109-ont0tqpn	190	36	]	]	-RRB-
cord-332109-ont0tqpn	190	37	.	.	.
cord-332109-ont0tqpn	191	1	Analysis	analysis	NN
cord-332109-ont0tqpn	191	2	of	of	IN
cord-332109-ont0tqpn	191	3	clinical	clinical	JJ
cord-332109-ont0tqpn	191	4	data	datum	NNS
cord-332109-ont0tqpn	191	5	has	have	VBZ
cord-332109-ont0tqpn	191	6	indicated	indicate	VBN
cord-332109-ont0tqpn	191	7	that	that	IN
cord-332109-ont0tqpn	191	8	smokers	smoker	NNS
cord-332109-ont0tqpn	191	9	are	be	VBP
cord-332109-ont0tqpn	191	10	twice	twice	RB
cord-332109-ont0tqpn	191	11	as	as	RB
cord-332109-ont0tqpn	191	12	much	much	JJ
cord-332109-ont0tqpn	191	13	as	as	IN
cord-332109-ont0tqpn	191	14	non	non	NNS
cord-332109-ont0tqpn	191	15	-	-	NNS
cord-332109-ont0tqpn	191	16	smokers	smoker	NNS
cord-332109-ont0tqpn	191	17	to	to	TO
cord-332109-ont0tqpn	191	18	contract	contract	VB
cord-332109-ont0tqpn	191	19	the	the	DT
cord-332109-ont0tqpn	191	20	virus	virus	NN
cord-332109-ont0tqpn	191	21	,	,	,
cord-332109-ont0tqpn	191	22	have	have	VBP
cord-332109-ont0tqpn	191	23	a	a	DT
cord-332109-ont0tqpn	191	24	more	more	RBR
cord-332109-ont0tqpn	191	25	severe	severe	JJ
cord-332109-ont0tqpn	191	26	disease	disease	NN
cord-332109-ont0tqpn	191	27	progression	progression	NN
cord-332109-ont0tqpn	191	28	,	,	,
cord-332109-ont0tqpn	191	29	and	and	CC
cord-332109-ont0tqpn	191	30	have	have	VBP
cord-332109-ont0tqpn	191	31	higher	high	JJR
cord-332109-ont0tqpn	191	32	mortality	mortality	NN
cord-332109-ont0tqpn	191	33	rates	rate	NNS
cord-332109-ont0tqpn	191	34	[	[	-LRB-
cord-332109-ont0tqpn	191	35	85	85	CD
cord-332109-ont0tqpn	191	36	]	]	-RRB-
cord-332109-ont0tqpn	191	37	.	.	.
cord-332109-ont0tqpn	192	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	192	2	induces	induce	VBZ
cord-332109-ont0tqpn	192	3	BBB	BBB	NNP
cord-332109-ont0tqpn	192	4	leakage	leakage	NN
cord-332109-ont0tqpn	192	5	and	and	CC
cord-332109-ont0tqpn	192	6	increases	increase	VBZ
cord-332109-ont0tqpn	192	7	BBB	BBB	NNP
cord-332109-ont0tqpn	192	8	permeability	permeability	NN
cord-332109-ont0tqpn	192	9	by	by	IN
cord-332109-ont0tqpn	192	10	diminishing	diminish	VBG
cord-332109-ont0tqpn	192	11	the	the	DT
cord-332109-ont0tqpn	192	12	expression	expression	NN
cord-332109-ont0tqpn	192	13	of	of	IN
cord-332109-ont0tqpn	192	14	tight	tight	JJ
cord-332109-ont0tqpn	192	15	junction	junction	NN
cord-332109-ont0tqpn	192	16	proteins	protein	NNS
cord-332109-ont0tqpn	192	17	,	,	,
cord-332109-ont0tqpn	192	18	including	include	VBG
cord-332109-ont0tqpn	192	19	occludin	occludin	NN
cord-332109-ont0tqpn	192	20	,	,	,
cord-332109-ont0tqpn	192	21	claudin-3	claudin-3	NNP
cord-332109-ont0tqpn	192	22	,	,	,
cord-332109-ont0tqpn	192	23	ZO-1	ZO-1	NNP
cord-332109-ont0tqpn	192	24	,	,	,
cord-332109-ont0tqpn	192	25	and	and	CC
cord-332109-ont0tqpn	192	26	JAMs	jam	NNS
cord-332109-ont0tqpn	192	27	[	[	-LRB-
cord-332109-ont0tqpn	192	28	86	86	CD
cord-332109-ont0tqpn	192	29	]	]	-RRB-
cord-332109-ont0tqpn	192	30	[	[	-LRB-
cord-332109-ont0tqpn	192	31	87	87	CD
cord-332109-ont0tqpn	192	32	]	]	-RRB-
cord-332109-ont0tqpn	192	33	[	[	-LRB-
cord-332109-ont0tqpn	192	34	88	88	CD
cord-332109-ont0tqpn	192	35	]	]	-RRB-
cord-332109-ont0tqpn	192	36	[	[	-LRB-
cord-332109-ont0tqpn	192	37	89	89	CD
cord-332109-ont0tqpn	192	38	]	]	-RRB-
cord-332109-ont0tqpn	192	39	.	.	.
cord-332109-ont0tqpn	193	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	193	2	alters	alter	VBZ
cord-332109-ont0tqpn	193	3	actin	actin	NN
cord-332109-ont0tqpn	193	4	cytoskeleton	cytoskeleton	NN
cord-332109-ont0tqpn	193	5	arrangement	arrangement	NN
cord-332109-ont0tqpn	193	6	in	in	IN
cord-332109-ont0tqpn	193	7	the	the	DT
cord-332109-ont0tqpn	193	8	BMVEC	BMVEC	NNP
cord-332109-ont0tqpn	193	9	,	,	,
cord-332109-ont0tqpn	193	10	which	which	WDT
cord-332109-ont0tqpn	193	11	also	also	RB
cord-332109-ont0tqpn	193	12	greatly	greatly	RB
cord-332109-ont0tqpn	193	13	increases	increase	VBZ
cord-332109-ont0tqpn	193	14	BBB	BBB	NNP
cord-332109-ont0tqpn	193	15	permeability	permeability	NN
cord-332109-ont0tqpn	193	16	,	,	,
cord-332109-ont0tqpn	193	17	resulting	result	VBG
cord-332109-ont0tqpn	193	18	in	in	IN
cord-332109-ont0tqpn	193	19	a	a	DT
cord-332109-ont0tqpn	193	20	surge	surge	NN
cord-332109-ont0tqpn	193	21	of	of	IN
cord-332109-ont0tqpn	193	22	bacterial	bacterial	JJ
cord-332109-ont0tqpn	193	23	invasion	invasion	NN
cord-332109-ont0tqpn	193	24	to	to	IN
cord-332109-ont0tqpn	193	25	the	the	DT
cord-332109-ont0tqpn	193	26	brain	brain	NN
cord-332109-ont0tqpn	193	27	[	[	-LRB-
cord-332109-ont0tqpn	193	28	90	90	CD
cord-332109-ont0tqpn	193	29	]	]	-RRB-
cord-332109-ont0tqpn	193	30	.	.	.
cord-332109-ont0tqpn	194	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	194	2	induces	induce	VBZ
cord-332109-ont0tqpn	194	3	oxidative	oxidative	JJ
cord-332109-ont0tqpn	194	4	stress	stress	NN
cord-332109-ont0tqpn	194	5	,	,	,
cord-332109-ont0tqpn	194	6	which	which	WDT
cord-332109-ont0tqpn	194	7	can	can	MD
cord-332109-ont0tqpn	194	8	progressively	progressively	RB
cord-332109-ont0tqpn	194	9	compromise	compromise	VB
cord-332109-ont0tqpn	194	10	the	the	DT
cord-332109-ont0tqpn	194	11	BBB	BBB	NNP
cord-332109-ont0tqpn	194	12	integrity	integrity	NN
cord-332109-ont0tqpn	194	13	[	[	-LRB-
cord-332109-ont0tqpn	194	14	91	91	CD
cord-332109-ont0tqpn	194	15	]	]	-RRB-
cord-332109-ont0tqpn	194	16	.	.	.
cord-332109-ont0tqpn	195	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	195	2	increases	increase	VBZ
cord-332109-ont0tqpn	195	3	gene	gene	NN
cord-332109-ont0tqpn	195	4	expression	expression	NN
cord-332109-ont0tqpn	195	5	of	of	IN
cord-332109-ont0tqpn	195	6	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	195	7	cytokines	cytokine	NNS
cord-332109-ont0tqpn	195	8	,	,	,
cord-332109-ont0tqpn	195	9	TNFα	TNFα	NNS
cord-332109-ont0tqpn	195	10	,	,	,
cord-332109-ont0tqpn	195	11	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	195	12	,	,	,
cord-332109-ont0tqpn	195	13	and	and	CC
cord-332109-ont0tqpn	195	14	IL-18	IL-18	NNP
cord-332109-ont0tqpn	195	15	,	,	,
cord-332109-ont0tqpn	195	16	and	and	CC
cord-332109-ont0tqpn	195	17	chemokines	chemokine	NNS
cord-332109-ont0tqpn	195	18	,	,	,
cord-332109-ont0tqpn	195	19	CCL2	CCL2	NNP
cord-332109-ont0tqpn	195	20	,	,	,
cord-332109-ont0tqpn	195	21	CCL8	CCL8	NNP
cord-332109-ont0tqpn	195	22	,	,	,
cord-332109-ont0tqpn	195	23	and	and	CC
cord-332109-ont0tqpn	195	24	CXC3CL1	CXC3CL1	NNP
cord-332109-ont0tqpn	195	25	,	,	,
cord-332109-ont0tqpn	195	26	and	and	CC
cord-332109-ont0tqpn	195	27	suppresses	suppress	VBZ
cord-332109-ont0tqpn	195	28	anti	anti	JJ
cord-332109-ont0tqpn	195	29	-	-	JJ
cord-332109-ont0tqpn	195	30	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	195	31	factors	factor	NNS
cord-332109-ont0tqpn	195	32	,	,	,
cord-332109-ont0tqpn	195	33	Bcl6	Bcl6	NNP
cord-332109-ont0tqpn	195	34	,	,	,
cord-332109-ont0tqpn	195	35	IL-10	IL-10	NNP
cord-332109-ont0tqpn	195	36	,	,	,
cord-332109-ont0tqpn	195	37	and	and	CC
cord-332109-ont0tqpn	195	38	CCL25	CCL25	NNP
cord-332109-ont0tqpn	195	39	in	in	IN
cord-332109-ont0tqpn	195	40	the	the	DT
cord-332109-ont0tqpn	195	41	brain	brain	NN
cord-332109-ont0tqpn	195	42	microvessels	microvessel	NNS
cord-332109-ont0tqpn	195	43	[	[	-LRB-
cord-332109-ont0tqpn	195	44	92	92	CD
cord-332109-ont0tqpn	195	45	]	]	-RRB-
cord-332109-ont0tqpn	195	46	.	.	.
cord-332109-ont0tqpn	196	1	Nicotine	nicotine	NN
cord-332109-ont0tqpn	196	2	's	's	POS
cord-332109-ont0tqpn	196	3	detrimental	detrimental	JJ
cord-332109-ont0tqpn	196	4	effects	effect	NNS
cord-332109-ont0tqpn	196	5	on	on	IN
cord-332109-ont0tqpn	196	6	the	the	DT
cord-332109-ont0tqpn	196	7	BBB	BBB	NNP
cord-332109-ont0tqpn	196	8	and	and	CC
cord-332109-ont0tqpn	196	9	induced	induce	VBN
cord-332109-ont0tqpn	196	10	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	196	11	are	be	VBP
cord-332109-ont0tqpn	196	12	serious	serious	JJ
cord-332109-ont0tqpn	196	13	concerns	concern	NNS
cord-332109-ont0tqpn	196	14	for	for	IN
cord-332109-ont0tqpn	196	15	COVID-19	covid-19	NN
cord-332109-ont0tqpn	196	16	.	.	.
cord-332109-ont0tqpn	197	1	The	the	DT
cord-332109-ont0tqpn	197	2	history	history	NN
cord-332109-ont0tqpn	197	3	of	of	IN
cord-332109-ont0tqpn	197	4	fermentation	fermentation	NN
cord-332109-ont0tqpn	197	5	production	production	NN
cord-332109-ont0tqpn	197	6	and	and	CC
cord-332109-ont0tqpn	197	7	the	the	DT
cord-332109-ont0tqpn	197	8	use	use	NN
cord-332109-ont0tqpn	197	9	of	of	IN
cord-332109-ont0tqpn	197	10	alcohol	alcohol	NN
cord-332109-ont0tqpn	197	11	can	can	MD
cord-332109-ont0tqpn	197	12	be	be	VB
cord-332109-ont0tqpn	197	13	dated	date	VBN
cord-332109-ont0tqpn	197	14	back	back	RB
cord-332109-ont0tqpn	197	15	to	to	IN
cord-332109-ont0tqpn	197	16	10,000	10,000	CD
cord-332109-ont0tqpn	197	17	BC	BC	NNP
cord-332109-ont0tqpn	197	18	.	.	.
cord-332109-ont0tqpn	198	1	Although	although	IN
cord-332109-ont0tqpn	198	2	light	light	NN
cord-332109-ont0tqpn	198	3	-	-	HYPH
cord-332109-ont0tqpn	198	4	to	to	IN
cord-332109-ont0tqpn	198	5	-	-	HYPH
cord-332109-ont0tqpn	198	6	moderate	moderate	JJ
cord-332109-ont0tqpn	198	7	consumption	consumption	NN
cord-332109-ont0tqpn	198	8	may	may	MD
cord-332109-ont0tqpn	198	9	arguably	arguably	RB
cord-332109-ont0tqpn	198	10	have	have	VB
cord-332109-ont0tqpn	198	11	positive	positive	JJ
cord-332109-ont0tqpn	198	12	health	health	NN
cord-332109-ont0tqpn	198	13	benefits	benefit	NNS
cord-332109-ont0tqpn	198	14	,	,	,
cord-332109-ont0tqpn	198	15	particularly	particularly	RB
cord-332109-ont0tqpn	198	16	in	in	IN
cord-332109-ont0tqpn	198	17	lowering	lower	VBG
cord-332109-ont0tqpn	198	18	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	198	19	risks	risk	NNS
cord-332109-ont0tqpn	198	20	[	[	-LRB-
cord-332109-ont0tqpn	198	21	93	93	CD
cord-332109-ont0tqpn	198	22	,	,	,
cord-332109-ont0tqpn	198	23	94	94	CD
cord-332109-ont0tqpn	198	24	]	]	-RRB-
cord-332109-ont0tqpn	198	25	,	,	,
cord-332109-ont0tqpn	198	26	high	high	JJ
cord-332109-ont0tqpn	198	27	dose	dose	NN
cord-332109-ont0tqpn	198	28	alcohol	alcohol	NN
cord-332109-ont0tqpn	198	29	can	can	MD
cord-332109-ont0tqpn	198	30	have	have	VB
cord-332109-ont0tqpn	198	31	severe	severe	JJ
cord-332109-ont0tqpn	198	32	neurotoxic	neurotoxic	JJ
cord-332109-ont0tqpn	198	33	effects	effect	NNS
cord-332109-ont0tqpn	198	34	and	and	CC
cord-332109-ont0tqpn	198	35	cause	cause	VB
cord-332109-ont0tqpn	198	36	dementia	dementia	NN
cord-332109-ont0tqpn	198	37	[	[	-LRB-
cord-332109-ont0tqpn	198	38	95	95	CD
cord-332109-ont0tqpn	198	39	]	]	-RRB-
cord-332109-ont0tqpn	198	40	.	.	.
cord-332109-ont0tqpn	199	1	Alcohol	alcohol	NN
cord-332109-ont0tqpn	199	2	has	have	VBZ
cord-332109-ont0tqpn	199	3	been	be	VBN
cord-332109-ont0tqpn	199	4	linked	link	VBN
cord-332109-ont0tqpn	199	5	to	to	IN
cord-332109-ont0tqpn	199	6	liver	liver	NN
cord-332109-ont0tqpn	199	7	damage	damage	NN
cord-332109-ont0tqpn	199	8	,	,	,
cord-332109-ont0tqpn	199	9	inflammation	inflammation	NN
cord-332109-ont0tqpn	199	10	of	of	IN
cord-332109-ont0tqpn	199	11	the	the	DT
cord-332109-ont0tqpn	199	12	pancreas	pancreas	NN
cord-332109-ont0tqpn	199	13	and	and	CC
cord-332109-ont0tqpn	199	14	stomach	stomach	NN
cord-332109-ont0tqpn	199	15	,	,	,
cord-332109-ont0tqpn	199	16	and	and	CC
cord-332109-ont0tqpn	199	17	neurodegenerative	neurodegenerative	JJ
cord-332109-ont0tqpn	199	18	disorders	disorder	NNS
cord-332109-ont0tqpn	199	19	.	.	.
cord-332109-ont0tqpn	200	1	High	high	JJ
cord-332109-ont0tqpn	200	2	alcohol	alcohol	NN
cord-332109-ont0tqpn	200	3	consumption	consumption	NN
cord-332109-ont0tqpn	200	4	changes	change	VBZ
cord-332109-ont0tqpn	200	5	gene	gene	NN
cord-332109-ont0tqpn	200	6	expression	expression	NN
cord-332109-ont0tqpn	200	7	of	of	IN
cord-332109-ont0tqpn	200	8	immune	immune	JJ
cord-332109-ont0tqpn	200	9	response	response	NN
cord-332109-ont0tqpn	200	10	genes	gene	NNS
cord-332109-ont0tqpn	200	11	in	in	IN
cord-332109-ont0tqpn	200	12	the	the	DT
cord-332109-ont0tqpn	200	13	brain	brain	NN
cord-332109-ont0tqpn	200	14	region	region	NN
cord-332109-ont0tqpn	200	15	frontal	frontal	JJ
cord-332109-ont0tqpn	200	16	cortex	cortex	NNP
cord-332109-ont0tqpn	200	17	[	[	-LRB-
cord-332109-ont0tqpn	200	18	96	96	CD
cord-332109-ont0tqpn	200	19	]	]	-RRB-
cord-332109-ont0tqpn	200	20	.	.	.
cord-332109-ont0tqpn	201	1	Proinflammatory	Proinflammatory	NNP
cord-332109-ont0tqpn	201	2	signaling	signaling	NN
cord-332109-ont0tqpn	201	3	is	be	VBZ
cord-332109-ont0tqpn	201	4	also	also	RB
cord-332109-ont0tqpn	201	5	connected	connect	VBN
cord-332109-ont0tqpn	201	6	to	to	IN
cord-332109-ont0tqpn	201	7	high	high	JJ
cord-332109-ont0tqpn	201	8	alcohol	alcohol	NN
cord-332109-ont0tqpn	201	9	intake	intake	NN
cord-332109-ont0tqpn	201	10	[	[	-LRB-
cord-332109-ont0tqpn	201	11	97	97	CD
cord-332109-ont0tqpn	201	12	]	]	-RRB-
cord-332109-ont0tqpn	201	13	.	.	.
cord-332109-ont0tqpn	202	1	Binge	binge	NN
cord-332109-ont0tqpn	202	2	alcohol	alcohol	NN
cord-332109-ont0tqpn	202	3	(	(	-LRB-
cord-332109-ont0tqpn	202	4	blood	blood	NN
cord-332109-ont0tqpn	202	5	alcohol	alcohol	NN
cord-332109-ont0tqpn	202	6	content	content	NN
cord-332109-ont0tqpn	203	1	B.A.C	B.A.C	NNP
cord-332109-ont0tqpn	204	1	≥	≥	CD
cord-332109-ont0tqpn	204	2	0.08	0.08	CD
cord-332109-ont0tqpn	204	3	%	%	NN
cord-332109-ont0tqpn	204	4	)	)	-RRB-
cord-332109-ont0tqpn	204	5	elevates	elevate	VBZ
cord-332109-ont0tqpn	204	6	expression	expression	NN
cord-332109-ont0tqpn	204	7	of	of	IN
cord-332109-ont0tqpn	204	8	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	204	9	cytokines	cytokine	NNS
cord-332109-ont0tqpn	204	10	,	,	,
cord-332109-ont0tqpn	204	11	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	204	12	and	and	CC
cord-332109-ont0tqpn	204	13	IL-6	IL-6	NNP
cord-332109-ont0tqpn	204	14	,	,	,
cord-332109-ont0tqpn	204	15	and	and	CC
cord-332109-ont0tqpn	204	16	chemokine	chemokine	NN
cord-332109-ont0tqpn	204	17	CCL-2	CCL-2	NNP
cord-332109-ont0tqpn	205	1	(	(	-LRB-
cord-332109-ont0tqpn	205	2	MCP-1	MCP-1	NNP
cord-332109-ont0tqpn	205	3	)	)	-RRB-
cord-332109-ont0tqpn	205	4	[	[	-LRB-
cord-332109-ont0tqpn	205	5	98	98	CD
cord-332109-ont0tqpn	205	6	]	]	-RRB-
cord-332109-ont0tqpn	205	7	.	.	.
cord-332109-ont0tqpn	206	1	Binge	binge	NN
cord-332109-ont0tqpn	206	2	alcohol	alcohol	NN
cord-332109-ont0tqpn	206	3	can	can	MD
cord-332109-ont0tqpn	206	4	also	also	RB
cord-332109-ont0tqpn	206	5	damage	damage	VB
cord-332109-ont0tqpn	206	6	various	various	JJ
cord-332109-ont0tqpn	206	7	organs	organ	NNS
cord-332109-ont0tqpn	206	8	,	,	,
cord-332109-ont0tqpn	206	9	including	include	VBG
cord-332109-ont0tqpn	206	10	the	the	DT
cord-332109-ont0tqpn	206	11	gut	gut	NN
cord-332109-ont0tqpn	206	12	,	,	,
cord-332109-ont0tqpn	206	13	liver	liver	NN
cord-332109-ont0tqpn	206	14	,	,	,
cord-332109-ont0tqpn	206	15	and	and	CC
cord-332109-ont0tqpn	206	16	brain	brain	NN
cord-332109-ont0tqpn	206	17	[	[	-LRB-
cord-332109-ont0tqpn	206	18	99	99	CD
cord-332109-ont0tqpn	206	19	]	]	-RRB-
cord-332109-ont0tqpn	206	20	,	,	,
cord-332109-ont0tqpn	206	21	and	and	CC
cord-332109-ont0tqpn	206	22	lead	lead	VB
cord-332109-ont0tqpn	206	23	to	to	IN
cord-332109-ont0tqpn	206	24	spleen	spleen	NN
cord-332109-ont0tqpn	206	25	atrophy	atrophy	NN
cord-332109-ont0tqpn	206	26	in	in	IN
cord-332109-ont0tqpn	206	27	a	a	DT
cord-332109-ont0tqpn	206	28	hippocampus	hippocampus	NN
cord-332109-ont0tqpn	206	29	-	-	HYPH
cord-332109-ont0tqpn	206	30	mediated	mediate	VBN
cord-332109-ont0tqpn	206	31	fashion	fashion	NN
cord-332109-ont0tqpn	206	32	[	[	-LRB-
cord-332109-ont0tqpn	206	33	100	100	CD
cord-332109-ont0tqpn	206	34	]	]	-RRB-
cord-332109-ont0tqpn	206	35	.	.	.
cord-332109-ont0tqpn	207	1	As	as	IN
cord-332109-ont0tqpn	207	2	suggested	suggest	VBN
cord-332109-ont0tqpn	207	3	in	in	IN
cord-332109-ont0tqpn	207	4	a	a	DT
cord-332109-ont0tqpn	207	5	comparative	comparative	JJ
cord-332109-ont0tqpn	207	6	risk	risk	NN
cord-332109-ont0tqpn	207	7	assessment	assessment	NN
cord-332109-ont0tqpn	207	8	using	use	VBG
cord-332109-ont0tqpn	207	9	the	the	DT
cord-332109-ont0tqpn	207	10	margin	margin	NN
cord-332109-ont0tqpn	207	11	of	of	IN
cord-332109-ont0tqpn	207	12	exposure	exposure	NN
cord-332109-ont0tqpn	207	13	(	(	-LRB-
cord-332109-ont0tqpn	207	14	MOE	MOE	NNP
cord-332109-ont0tqpn	207	15	)	)	-RRB-
cord-332109-ont0tqpn	207	16	benchmark	benchmark	NN
cord-332109-ont0tqpn	207	17	,	,	,
cord-332109-ont0tqpn	207	18	alcohol	alcohol	NN
cord-332109-ont0tqpn	207	19	is	be	VBZ
cord-332109-ont0tqpn	207	20	considered	consider	VBN
cord-332109-ont0tqpn	207	21	to	to	TO
cord-332109-ont0tqpn	207	22	have	have	VB
cord-332109-ont0tqpn	207	23	the	the	DT
cord-332109-ont0tqpn	207	24	highest	high	JJS
cord-332109-ont0tqpn	207	25	risk	risk	NN
cord-332109-ont0tqpn	207	26	of	of	IN
cord-332109-ont0tqpn	207	27	mortality	mortality	NN
cord-332109-ont0tqpn	207	28	[	[	-LRB-
cord-332109-ont0tqpn	207	29	101	101	CD
cord-332109-ont0tqpn	207	30	]	]	-RRB-
cord-332109-ont0tqpn	207	31	.	.	.
cord-332109-ont0tqpn	208	1	The	the	DT
cord-332109-ont0tqpn	208	2	alcohol	alcohol	NN
cord-332109-ont0tqpn	208	3	-	-	HYPH
cord-332109-ont0tqpn	208	4	induced	induce	VBN
cord-332109-ont0tqpn	208	5	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	208	6	cytokine	cytokine	NN
cord-332109-ont0tqpn	208	7	release	release	NN
cord-332109-ont0tqpn	208	8	could	could	MD
cord-332109-ont0tqpn	208	9	expose	expose	VB
cord-332109-ont0tqpn	208	10	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	208	11	patients	patient	NNS
cord-332109-ont0tqpn	208	12	to	to	TO
cord-332109-ont0tqpn	208	13	excessive	excessive	JJ
cord-332109-ont0tqpn	208	14	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	208	15	responses	response	NNS
cord-332109-ont0tqpn	208	16	.	.	.
cord-332109-ont0tqpn	209	1	The	the	DT
cord-332109-ont0tqpn	209	2	spleen	spleen	NN
cord-332109-ont0tqpn	209	3	damage	damage	NN
cord-332109-ont0tqpn	209	4	by	by	IN
cord-332109-ont0tqpn	209	5	alcohol	alcohol	NN
cord-332109-ont0tqpn	209	6	could	could	MD
cord-332109-ont0tqpn	209	7	weaken	weaken	VB
cord-332109-ont0tqpn	209	8	the	the	DT
cord-332109-ont0tqpn	209	9	immune	immune	JJ
cord-332109-ont0tqpn	209	10	response	response	NN
cord-332109-ont0tqpn	209	11	in	in	IN
cord-332109-ont0tqpn	209	12	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	209	13	by	by	IN
cord-332109-ont0tqpn	209	14	reducing	reduce	VBG
cord-332109-ont0tqpn	209	15	the	the	DT
cord-332109-ont0tqpn	209	16	production	production	NN
cord-332109-ont0tqpn	209	17	of	of	IN
cord-332109-ont0tqpn	209	18	antibodies	antibody	NNS
cord-332109-ont0tqpn	209	19	and	and	CC
cord-332109-ont0tqpn	209	20	lymphocytes	lymphocyte	NNS
cord-332109-ont0tqpn	209	21	against	against	IN
cord-332109-ont0tqpn	209	22	the	the	DT
cord-332109-ont0tqpn	209	23	virus	virus	NN
cord-332109-ont0tqpn	209	24	[	[	-LRB-
cord-332109-ont0tqpn	209	25	102	102	CD
cord-332109-ont0tqpn	209	26	]	]	-RRB-
cord-332109-ont0tqpn	209	27	.	.	.
cord-332109-ont0tqpn	210	1	Alcohol	alcohol	NN
cord-332109-ont0tqpn	210	2	can	can	MD
cord-332109-ont0tqpn	210	3	induce	induce	VB
cord-332109-ont0tqpn	210	4	BBB	BBB	NNP
cord-332109-ont0tqpn	210	5	disruption	disruption	NN
cord-332109-ont0tqpn	210	6	by	by	IN
cord-332109-ont0tqpn	210	7	decreasing	decrease	VBG
cord-332109-ont0tqpn	210	8	the	the	DT
cord-332109-ont0tqpn	210	9	expression	expression	NN
cord-332109-ont0tqpn	210	10	of	of	IN
cord-332109-ont0tqpn	210	11	tight	tight	JJ
cord-332109-ont0tqpn	210	12	junction	junction	NN
cord-332109-ont0tqpn	210	13	proteins	protein	NNS
cord-332109-ont0tqpn	210	14	and	and	CC
cord-332109-ont0tqpn	210	15	increasing	increase	VBG
cord-332109-ont0tqpn	210	16	mitogen	mitogen	NN
cord-332109-ont0tqpn	210	17	-	-	HYPH
cord-332109-ont0tqpn	210	18	activated	activate	VBN
cord-332109-ont0tqpn	210	19	protein	protein	NN
cord-332109-ont0tqpn	210	20	kinase	kinase	NN
cord-332109-ont0tqpn	210	21	(	(	-LRB-
cord-332109-ont0tqpn	210	22	MAPK	MAPK	NNP
cord-332109-ont0tqpn	210	23	)	)	-RRB-
cord-332109-ont0tqpn	210	24	activities	activity	NNS
cord-332109-ont0tqpn	210	25	[	[	-LRB-
cord-332109-ont0tqpn	210	26	103	103	CD
cord-332109-ont0tqpn	210	27	]	]	-RRB-
cord-332109-ont0tqpn	210	28	.	.	.
cord-332109-ont0tqpn	211	1	Alcohol	alcohol	NN
cord-332109-ont0tqpn	211	2	may	may	MD
cord-332109-ont0tqpn	211	3	also	also	RB
cord-332109-ont0tqpn	211	4	stimulate	stimulate	VB
cord-332109-ont0tqpn	211	5	inositol	inositol	NN
cord-332109-ont0tqpn	211	6	1,4,5-triphosphate	1,4,5-triphosphate	CD
cord-332109-ont0tqpn	211	7	receptor	receptor	NN
cord-332109-ont0tqpn	211	8	(	(	-LRB-
cord-332109-ont0tqpn	211	9	IP3R)-operated	ip3r)-operate	VBN
cord-332109-ont0tqpn	211	10	intracellular	intracellular	JJ
cord-332109-ont0tqpn	212	1	Ca	ca	NN
cord-332109-ont0tqpn	212	2	2	2	CD
cord-332109-ont0tqpn	212	3	+	+	CC
cord-332109-ont0tqpn	212	4	release	release	NN
cord-332109-ont0tqpn	212	5	,	,	,
cord-332109-ont0tqpn	212	6	activating	activate	VBG
cord-332109-ont0tqpn	212	7	myosin	myosin	NN
cord-332109-ont0tqpn	212	8	light	light	JJ
cord-332109-ont0tqpn	212	9	chain	chain	NN
cord-332109-ont0tqpn	212	10	kinase	kinase	NN
cord-332109-ont0tqpn	212	11	(	(	-LRB-
cord-332109-ont0tqpn	212	12	MLCK	MLCK	NNP
cord-332109-ont0tqpn	212	13	)	)	-RRB-
cord-332109-ont0tqpn	212	14	.	.	.
cord-332109-ont0tqpn	213	1	The	the	DT
cord-332109-ont0tqpn	213	2	heightened	heightened	JJ
cord-332109-ont0tqpn	213	3	kinase	kinase	NN
cord-332109-ont0tqpn	213	4	activities	activity	NNS
cord-332109-ont0tqpn	213	5	lead	lead	VBP
cord-332109-ont0tqpn	213	6	to	to	IN
cord-332109-ont0tqpn	213	7	the	the	DT
cord-332109-ont0tqpn	213	8	phosphorylation	phosphorylation	NN
cord-332109-ont0tqpn	213	9	of	of	IN
cord-332109-ont0tqpn	213	10	cytoskeletal	cytoskeletal	JJ
cord-332109-ont0tqpn	213	11	and	and	CC
cord-332109-ont0tqpn	213	12	tight	tight	JJ
cord-332109-ont0tqpn	213	13	junction	junction	NN
cord-332109-ont0tqpn	213	14	proteins	protein	NNS
cord-332109-ont0tqpn	213	15	,	,	,
cord-332109-ont0tqpn	213	16	compromising	compromise	VBG
cord-332109-ont0tqpn	213	17	the	the	DT
cord-332109-ont0tqpn	213	18	BBB	BBB	NNP
cord-332109-ont0tqpn	213	19	integrity	integrity	NN
cord-332109-ont0tqpn	213	20	[	[	-LRB-
cord-332109-ont0tqpn	213	21	104	104	CD
cord-332109-ont0tqpn	213	22	]	]	-RRB-
cord-332109-ont0tqpn	213	23	.	.	.
cord-332109-ont0tqpn	214	1	Alcohol	alcohol	NN
cord-332109-ont0tqpn	214	2	-	-	HYPH
cord-332109-ont0tqpn	214	3	mediated	mediate	VBN
cord-332109-ont0tqpn	214	4	oxidative	oxidative	JJ
cord-332109-ont0tqpn	214	5	stress	stress	NN
cord-332109-ont0tqpn	214	6	in	in	IN
cord-332109-ont0tqpn	214	7	BMVEC	BMVEC	NNP
cord-332109-ont0tqpn	214	8	can	can	MD
cord-332109-ont0tqpn	214	9	also	also	RB
cord-332109-ont0tqpn	214	10	activate	activate	VB
cord-332109-ont0tqpn	214	11	MLCK	MLCK	NNP
cord-332109-ont0tqpn	214	12	that	that	WDT
cord-332109-ont0tqpn	214	13	alters	alter	VBZ
cord-332109-ont0tqpn	214	14	cytoskeleton	cytoskeleton	NN
cord-332109-ont0tqpn	214	15	and	and	CC
cord-332109-ont0tqpn	214	16	tight	tight	JJ
cord-332109-ont0tqpn	214	17	junction	junction	NN
cord-332109-ont0tqpn	214	18	protein	protein	NN
cord-332109-ont0tqpn	214	19	structures	structure	NNS
cord-332109-ont0tqpn	214	20	,	,	,
cord-332109-ont0tqpn	214	21	causing	cause	VBG
cord-332109-ont0tqpn	214	22	BBB	bbb	NN
cord-332109-ont0tqpn	214	23	leakage	leakage	NN
cord-332109-ont0tqpn	214	24	[	[	-LRB-
cord-332109-ont0tqpn	214	25	105	105	CD
cord-332109-ont0tqpn	214	26	]	]	-RRB-
cord-332109-ont0tqpn	214	27	.	.	.
cord-332109-ont0tqpn	215	1	Disruption	disruption	NN
cord-332109-ont0tqpn	215	2	of	of	IN
cord-332109-ont0tqpn	215	3	the	the	DT
cord-332109-ont0tqpn	215	4	BBB	BBB	NNP
cord-332109-ont0tqpn	215	5	associated	associate	VBN
cord-332109-ont0tqpn	215	6	with	with	IN
cord-332109-ont0tqpn	215	7	chronic	chronic	JJ
cord-332109-ont0tqpn	215	8	alcohol	alcohol	NN
cord-332109-ont0tqpn	215	9	use	use	NN
cord-332109-ont0tqpn	215	10	could	could	MD
cord-332109-ont0tqpn	215	11	increase	increase	VB
cord-332109-ont0tqpn	215	12	the	the	DT
cord-332109-ont0tqpn	215	13	possibilities	possibility	NNS
cord-332109-ont0tqpn	215	14	of	of	IN
cord-332109-ont0tqpn	215	15	invading	invade	VBG
cord-332109-ont0tqpn	215	16	pathogens	pathogen	NNS
cord-332109-ont0tqpn	215	17	,	,	,
cord-332109-ont0tqpn	215	18	including	include	VBG
cord-332109-ont0tqpn	215	19	SARS	SARS	NNP
cord-332109-ont0tqpn	215	20	-	-	HYPH
cord-332109-ont0tqpn	215	21	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	215	22	,	,	,
cord-332109-ont0tqpn	215	23	to	to	TO
cord-332109-ont0tqpn	215	24	infiltrate	infiltrate	VB
cord-332109-ont0tqpn	215	25	the	the	DT
cord-332109-ont0tqpn	215	26	brain	brain	NN
cord-332109-ont0tqpn	215	27	.	.	.
cord-332109-ont0tqpn	216	1	Marijuana	Marijuana	NNP
cord-332109-ont0tqpn	216	2	,	,	,
cord-332109-ont0tqpn	216	3	also	also	RB
cord-332109-ont0tqpn	216	4	known	know	VBN
cord-332109-ont0tqpn	216	5	as	as	IN
cord-332109-ont0tqpn	216	6	cannabis	cannabis	NN
cord-332109-ont0tqpn	216	7	,	,	,
cord-332109-ont0tqpn	216	8	is	be	VBZ
cord-332109-ont0tqpn	216	9	the	the	DT
cord-332109-ont0tqpn	216	10	most	most	RBS
cord-332109-ont0tqpn	216	11	frequently	frequently	RB
cord-332109-ont0tqpn	216	12	used	use	VBN
cord-332109-ont0tqpn	216	13	illicit	illicit	JJ
cord-332109-ont0tqpn	216	14	substance	substance	NN
cord-332109-ont0tqpn	216	15	of	of	IN
cord-332109-ont0tqpn	216	16	abuse	abuse	NN
cord-332109-ont0tqpn	216	17	in	in	IN
cord-332109-ont0tqpn	216	18	the	the	DT
cord-332109-ont0tqpn	216	19	U.S.	U.S.	NNP
cord-332109-ont0tqpn	217	1	Currently	currently	RB
cord-332109-ont0tqpn	217	2	,	,	,
cord-332109-ont0tqpn	217	3	11	11	CD
cord-332109-ont0tqpn	217	4	states	state	NNS
cord-332109-ont0tqpn	217	5	and	and	CC
cord-332109-ont0tqpn	217	6	the	the	DT
cord-332109-ont0tqpn	217	7	District	District	NNP
cord-332109-ont0tqpn	217	8	of	of	IN
cord-332109-ont0tqpn	217	9	Columbia	Columbia	NNP
cord-332109-ont0tqpn	217	10	have	have	VBP
cord-332109-ont0tqpn	217	11	legalized	legalize	VBN
cord-332109-ont0tqpn	217	12	the	the	DT
cord-332109-ont0tqpn	217	13	recreational	recreational	JJ
cord-332109-ont0tqpn	217	14	use	use	NN
cord-332109-ont0tqpn	217	15	of	of	IN
cord-332109-ont0tqpn	217	16	marijuana	marijuana	NN
cord-332109-ont0tqpn	217	17	,	,	,
cord-332109-ont0tqpn	217	18	and	and	CC
cord-332109-ont0tqpn	217	19	16	16	CD
cord-332109-ont0tqpn	217	20	states	state	NNS
cord-332109-ont0tqpn	217	21	have	have	VBP
cord-332109-ont0tqpn	217	22	decriminalized	decriminalize	VBN
cord-332109-ont0tqpn	217	23	marijuana	marijuana	NN
cord-332109-ont0tqpn	217	24	use	use	NN
cord-332109-ont0tqpn	217	25	and	and	CC
cord-332109-ont0tqpn	217	26	possession	possession	NN
cord-332109-ont0tqpn	217	27	.	.	.
cord-332109-ont0tqpn	218	1	The	the	DT
cord-332109-ont0tqpn	218	2	use	use	NN
cord-332109-ont0tqpn	218	3	of	of	IN
cord-332109-ont0tqpn	218	4	marijuana	marijuana	NN
cord-332109-ont0tqpn	218	5	for	for	IN
cord-332109-ont0tqpn	218	6	medical	medical	JJ
cord-332109-ont0tqpn	218	7	purposes	purpose	NNS
cord-332109-ont0tqpn	218	8	is	be	VBZ
cord-332109-ont0tqpn	218	9	legal	legal	JJ
cord-332109-ont0tqpn	218	10	in	in	IN
cord-332109-ont0tqpn	218	11	33	33	CD
cord-332109-ont0tqpn	218	12	states	state	NNS
cord-332109-ont0tqpn	218	13	.	.	.
cord-332109-ont0tqpn	219	1	It	-PRON-	PRP
cord-332109-ont0tqpn	219	2	is	be	VBZ
cord-332109-ont0tqpn	219	3	,	,	,
cord-332109-ont0tqpn	219	4	however	however	RB
cord-332109-ont0tqpn	219	5	,	,	,
cord-332109-ont0tqpn	219	6	illegal	illegal	JJ
cord-332109-ont0tqpn	219	7	under	under	IN
cord-332109-ont0tqpn	219	8	federal	federal	JJ
cord-332109-ont0tqpn	219	9	law	law	NN
cord-332109-ont0tqpn	219	10	to	to	TO
cord-332109-ont0tqpn	219	11	use	use	VB
cord-332109-ont0tqpn	219	12	and	and	CC
cord-332109-ont0tqpn	219	13	possess	possess	VB
cord-332109-ont0tqpn	219	14	marijuana	marijuana	NN
cord-332109-ont0tqpn	219	15	.	.	.
cord-332109-ont0tqpn	220	1	It	-PRON-	PRP
cord-332109-ont0tqpn	220	2	is	be	VBZ
cord-332109-ont0tqpn	220	3	classified	classify	VBN
cord-332109-ont0tqpn	220	4	as	as	IN
cord-332109-ont0tqpn	220	5	a	a	DT
cord-332109-ont0tqpn	220	6	Schedule	schedule	NN
cord-332109-ont0tqpn	220	7	I	-PRON-	PRP
cord-332109-ont0tqpn	220	8	substance	substance	NN
cord-332109-ont0tqpn	220	9	by	by	IN
cord-332109-ont0tqpn	220	10	the	the	DT
cord-332109-ont0tqpn	220	11	US	US	NNP
cord-332109-ont0tqpn	220	12	Drug	Drug	NNP
cord-332109-ont0tqpn	220	13	Enforcement	Enforcement	NNP
cord-332109-ont0tqpn	220	14	Administration	Administration	NNP
cord-332109-ont0tqpn	220	15	(	(	-LRB-
cord-332109-ont0tqpn	220	16	DEA	DEA	NNP
cord-332109-ont0tqpn	220	17	)	)	-RRB-
cord-332109-ont0tqpn	220	18	,	,	,
cord-332109-ont0tqpn	220	19	indicating	indicate	VBG
cord-332109-ont0tqpn	220	20	a	a	DT
cord-332109-ont0tqpn	220	21	high	high	JJ
cord-332109-ont0tqpn	220	22	potential	potential	NN
cord-332109-ont0tqpn	220	23	for	for	IN
cord-332109-ont0tqpn	220	24	abuse	abuse	NN
cord-332109-ont0tqpn	220	25	and	and	CC
cord-332109-ont0tqpn	220	26	no	no	DT
cord-332109-ont0tqpn	220	27	accepted	accept	VBN
cord-332109-ont0tqpn	220	28	medical	medical	JJ
cord-332109-ont0tqpn	220	29	use	use	NN
cord-332109-ont0tqpn	220	30	,	,	,
cord-332109-ont0tqpn	220	31	despite	despite	IN
cord-332109-ont0tqpn	220	32	the	the	DT
cord-332109-ont0tqpn	220	33	fact	fact	NN
cord-332109-ont0tqpn	220	34	that	that	IN
cord-332109-ont0tqpn	220	35	medical	medical	JJ
cord-332109-ont0tqpn	220	36	marijuana	marijuana	NN
cord-332109-ont0tqpn	220	37	has	have	VBZ
cord-332109-ont0tqpn	220	38	been	be	VBN
cord-332109-ont0tqpn	220	39	well	well	RB
cord-332109-ont0tqpn	220	40	established	establish	VBN
cord-332109-ont0tqpn	220	41	[	[	-LRB-
cord-332109-ont0tqpn	220	42	106	106	CD
cord-332109-ont0tqpn	220	43	,	,	,
cord-332109-ont0tqpn	220	44	107	107	CD
cord-332109-ont0tqpn	220	45	]	]	-RRB-
cord-332109-ont0tqpn	220	46	.	.	.
cord-332109-ont0tqpn	221	1	Two	two	CD
cord-332109-ont0tqpn	221	2	cannabinoids	cannabinoid	NNS
cord-332109-ont0tqpn	221	3	,	,	,
cord-332109-ont0tqpn	221	4	∆	∆	NNP
cord-332109-ont0tqpn	221	5	9	9	CD
cord-332109-ont0tqpn	221	6	-tetrahydrocannabinol	-tetrahydrocannabinol	CD
cord-332109-ont0tqpn	221	7	(	(	-LRB-
cord-332109-ont0tqpn	221	8	THC	THC	NNP
cord-332109-ont0tqpn	221	9	)	)	-RRB-
cord-332109-ont0tqpn	221	10	and	and	CC
cord-332109-ont0tqpn	221	11	cannabidiol	cannabidiol	FW
cord-332109-ont0tqpn	221	12	(	(	-LRB-
cord-332109-ont0tqpn	221	13	CBD	CBD	NNP
cord-332109-ont0tqpn	221	14	)	)	-RRB-
cord-332109-ont0tqpn	221	15	,	,	,
cord-332109-ont0tqpn	221	16	are	be	VBP
cord-332109-ont0tqpn	221	17	the	the	DT
cord-332109-ont0tqpn	221	18	main	main	JJ
cord-332109-ont0tqpn	221	19	active	active	JJ
cord-332109-ont0tqpn	221	20	ingredients	ingredient	NNS
cord-332109-ont0tqpn	221	21	in	in	IN
cord-332109-ont0tqpn	221	22	marijuana	marijuana	NN
cord-332109-ont0tqpn	221	23	.	.	.
cord-332109-ont0tqpn	222	1	Cannabinoids	cannabinoid	NNS
cord-332109-ont0tqpn	222	2	act	act	VBP
cord-332109-ont0tqpn	222	3	on	on	IN
cord-332109-ont0tqpn	222	4	the	the	DT
cord-332109-ont0tqpn	222	5	endocannabinoid	endocannabinoid	NN
cord-332109-ont0tqpn	222	6	system	system	NN
cord-332109-ont0tqpn	222	7	(	(	-LRB-
cord-332109-ont0tqpn	222	8	ECS	ECS	NNP
cord-332109-ont0tqpn	222	9	)	)	-RRB-
cord-332109-ont0tqpn	222	10	,	,	,
cord-332109-ont0tqpn	222	11	which	which	WDT
cord-332109-ont0tqpn	222	12	is	be	VBZ
cord-332109-ont0tqpn	222	13	composed	compose	VBN
cord-332109-ont0tqpn	222	14	of	of	IN
cord-332109-ont0tqpn	222	15	two	two	CD
cord-332109-ont0tqpn	222	16	cannabinoid	cannabinoid	NN
cord-332109-ont0tqpn	222	17	receptors	receptor	NNS
cord-332109-ont0tqpn	222	18	,	,	,
cord-332109-ont0tqpn	222	19	CB1	CB1	NNP
cord-332109-ont0tqpn	222	20	,	,	,
cord-332109-ont0tqpn	222	21	expressed	express	VBD
cord-332109-ont0tqpn	222	22	in	in	IN
cord-332109-ont0tqpn	222	23	most	most	JJS
cord-332109-ont0tqpn	222	24	neuronal	neuronal	JJ
cord-332109-ont0tqpn	222	25	cells	cell	NNS
cord-332109-ont0tqpn	222	26	,	,	,
cord-332109-ont0tqpn	222	27	and	and	CC
cord-332109-ont0tqpn	222	28	CB2	CB2	NNP
cord-332109-ont0tqpn	222	29	,	,	,
cord-332109-ont0tqpn	222	30	expressed	express	VBD
cord-332109-ont0tqpn	222	31	predominantly	predominantly	RB
cord-332109-ont0tqpn	222	32	in	in	IN
cord-332109-ont0tqpn	222	33	immune	immune	JJ
cord-332109-ont0tqpn	222	34	cells	cell	NNS
cord-332109-ont0tqpn	222	35	[	[	-LRB-
cord-332109-ont0tqpn	222	36	108	108	CD
cord-332109-ont0tqpn	222	37	]	]	-RRB-
cord-332109-ont0tqpn	222	38	.	.	.
cord-332109-ont0tqpn	223	1	THC	thc	NN
cord-332109-ont0tqpn	223	2	is	be	VBZ
cord-332109-ont0tqpn	223	3	the	the	DT
cord-332109-ont0tqpn	223	4	component	component	NN
cord-332109-ont0tqpn	223	5	that	that	WDT
cord-332109-ont0tqpn	223	6	produces	produce	VBZ
cord-332109-ont0tqpn	223	7	psychotropic	psychotropic	JJ
cord-332109-ont0tqpn	223	8	effects	effect	NNS
cord-332109-ont0tqpn	223	9	through	through	IN
cord-332109-ont0tqpn	223	10	stimulating	stimulate	VBG
cord-332109-ont0tqpn	223	11	the	the	DT
cord-332109-ont0tqpn	223	12	CB1	cb1	NN
cord-332109-ont0tqpn	223	13	receptor	receptor	NN
cord-332109-ont0tqpn	223	14	and	and	CC
cord-332109-ont0tqpn	223	15	mediating	mediate	VBG
cord-332109-ont0tqpn	223	16	the	the	DT
cord-332109-ont0tqpn	223	17	inhibition	inhibition	NN
cord-332109-ont0tqpn	223	18	of	of	IN
cord-332109-ont0tqpn	223	19	neurotransmitter	neurotransmitter	NN
cord-332109-ont0tqpn	223	20	release	release	NN
cord-332109-ont0tqpn	223	21	[	[	-LRB-
cord-332109-ont0tqpn	223	22	109	109	CD
cord-332109-ont0tqpn	223	23	]	]	-RRB-
cord-332109-ont0tqpn	223	24	.	.	.
cord-332109-ont0tqpn	224	1	CBD	CBD	NNP
cord-332109-ont0tqpn	224	2	is	be	VBZ
cord-332109-ont0tqpn	224	3	considered	consider	VBN
cord-332109-ont0tqpn	224	4	to	to	TO
cord-332109-ont0tqpn	224	5	regulate	regulate	VB
cord-332109-ont0tqpn	224	6	immune	immune	JJ
cord-332109-ont0tqpn	224	7	response	response	NN
cord-332109-ont0tqpn	224	8	,	,	,
cord-332109-ont0tqpn	224	9	such	such	JJ
cord-332109-ont0tqpn	224	10	as	as	IN
cord-332109-ont0tqpn	224	11	cytokine	cytokine	NN
cord-332109-ont0tqpn	224	12	release	release	NN
cord-332109-ont0tqpn	224	13	,	,	,
cord-332109-ont0tqpn	224	14	and	and	CC
cord-332109-ont0tqpn	224	15	blood	blood	NN
cord-332109-ont0tqpn	224	16	pressure	pressure	NN
cord-332109-ont0tqpn	224	17	,	,	,
cord-332109-ont0tqpn	224	18	with	with	IN
cord-332109-ont0tqpn	224	19	little	little	JJ
cord-332109-ont0tqpn	224	20	to	to	IN
cord-332109-ont0tqpn	224	21	no	no	DT
cord-332109-ont0tqpn	224	22	psychotropic	psychotropic	JJ
cord-332109-ont0tqpn	224	23	side	side	NN
cord-332109-ont0tqpn	224	24	effects	effect	NNS
cord-332109-ont0tqpn	224	25	,	,	,
cord-332109-ont0tqpn	224	26	as	as	IN
cord-332109-ont0tqpn	224	27	CBD	CBD	NNP
cord-332109-ont0tqpn	224	28	only	only	RB
cord-332109-ont0tqpn	224	29	binds	bind	VBZ
cord-332109-ont0tqpn	224	30	to	to	IN
cord-332109-ont0tqpn	224	31	CB2	CB2	NNP
cord-332109-ont0tqpn	224	32	but	but	CC
cord-332109-ont0tqpn	224	33	not	not	RB
cord-332109-ont0tqpn	224	34	to	to	IN
cord-332109-ont0tqpn	224	35	CB1	cb1	NN
cord-332109-ont0tqpn	224	36	receptors	receptor	NNS
cord-332109-ont0tqpn	224	37	[	[	-LRB-
cord-332109-ont0tqpn	224	38	109	109	CD
cord-332109-ont0tqpn	224	39	]	]	-RRB-
cord-332109-ont0tqpn	224	40	.	.	.
cord-332109-ont0tqpn	225	1	THC	thc	NN
cord-332109-ont0tqpn	225	2	can	can	MD
cord-332109-ont0tqpn	225	3	also	also	RB
cord-332109-ont0tqpn	225	4	activate	activate	VB
cord-332109-ont0tqpn	225	5	CB1	CB1	NNP
cord-332109-ont0tqpn	225	6	receptor	receptor	NN
cord-332109-ont0tqpn	225	7	in	in	IN
cord-332109-ont0tqpn	225	8	the	the	DT
cord-332109-ont0tqpn	225	9	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	225	10	system	system	NN
cord-332109-ont0tqpn	225	11	,	,	,
cord-332109-ont0tqpn	225	12	which	which	WDT
cord-332109-ont0tqpn	225	13	has	have	VBZ
cord-332109-ont0tqpn	225	14	been	be	VBN
cord-332109-ont0tqpn	225	15	associated	associate	VBN
cord-332109-ont0tqpn	225	16	with	with	IN
cord-332109-ont0tqpn	225	17	adverse	adverse	JJ
cord-332109-ont0tqpn	225	18	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	225	19	events	event	NNS
cord-332109-ont0tqpn	225	20	,	,	,
cord-332109-ont0tqpn	225	21	including	include	VBG
cord-332109-ont0tqpn	225	22	myocardial	myocardial	JJ
cord-332109-ont0tqpn	225	23	infarction	infarction	NN
cord-332109-ont0tqpn	225	24	,	,	,
cord-332109-ont0tqpn	225	25	cardiomyopathy	cardiomyopathy	NN
cord-332109-ont0tqpn	225	26	,	,	,
cord-332109-ont0tqpn	225	27	arrhythmias	arrhythmias	RB
cord-332109-ont0tqpn	225	28	,	,	,
cord-332109-ont0tqpn	225	29	stroke	stroke	NN
cord-332109-ont0tqpn	225	30	,	,	,
cord-332109-ont0tqpn	225	31	and	and	CC
cord-332109-ont0tqpn	225	32	cardiac	cardiac	JJ
cord-332109-ont0tqpn	225	33	arrest	arrest	NN
cord-332109-ont0tqpn	225	34	[	[	-LRB-
cord-332109-ont0tqpn	225	35	110	110	CD
cord-332109-ont0tqpn	225	36	]	]	-RRB-
cord-332109-ont0tqpn	225	37	.	.	.
cord-332109-ont0tqpn	226	1	Both	both	DT
cord-332109-ont0tqpn	226	2	THC	THC	NNP
cord-332109-ont0tqpn	226	3	and	and	CC
cord-332109-ont0tqpn	226	4	CBD	CBD	NNP
cord-332109-ont0tqpn	226	5	are	be	VBP
cord-332109-ont0tqpn	226	6	lipophilic	lipophilic	JJ
cord-332109-ont0tqpn	226	7	,	,	,
cord-332109-ont0tqpn	226	8	allowing	allow	VBG
cord-332109-ont0tqpn	226	9	them	-PRON-	PRP
cord-332109-ont0tqpn	226	10	to	to	TO
cord-332109-ont0tqpn	226	11	readily	readily	RB
cord-332109-ont0tqpn	226	12	pass	pass	VB
cord-332109-ont0tqpn	226	13	through	through	IN
cord-332109-ont0tqpn	226	14	the	the	DT
cord-332109-ont0tqpn	226	15	BBB	BBB	NNP
cord-332109-ont0tqpn	226	16	and	and	CC
cord-332109-ont0tqpn	226	17	enter	enter	VB
cord-332109-ont0tqpn	226	18	the	the	DT
cord-332109-ont0tqpn	226	19	CNS	CNS	NNP
cord-332109-ont0tqpn	226	20	.	.	.
cord-332109-ont0tqpn	227	1	THC	thc	NN
cord-332109-ont0tqpn	227	2	is	be	VBZ
cord-332109-ont0tqpn	227	3	an	an	DT
cord-332109-ont0tqpn	227	4	immunosuppressor	immunosuppressor	NN
cord-332109-ont0tqpn	227	5	.	.	.
cord-332109-ont0tqpn	228	1	It	-PRON-	PRP
cord-332109-ont0tqpn	228	2	has	have	VBZ
cord-332109-ont0tqpn	228	3	been	be	VBN
cord-332109-ont0tqpn	228	4	reported	report	VBN
cord-332109-ont0tqpn	228	5	to	to	TO
cord-332109-ont0tqpn	228	6	suppress	suppress	VB
cord-332109-ont0tqpn	228	7	antibody	antibody	NN
cord-332109-ont0tqpn	228	8	response	response	NN
cord-332109-ont0tqpn	228	9	and	and	CC
cord-332109-ont0tqpn	228	10	T	t	NN
cord-332109-ont0tqpn	228	11	lymphocytes	lymphocyte	NNS
cord-332109-ont0tqpn	228	12	activities	activity	NNS
cord-332109-ont0tqpn	228	13	.	.	.
cord-332109-ont0tqpn	229	1	It	-PRON-	PRP
cord-332109-ont0tqpn	229	2	prevents	prevent	VBZ
cord-332109-ont0tqpn	229	3	macrophage	macrophage	NN
cord-332109-ont0tqpn	229	4	and	and	CC
cord-332109-ont0tqpn	229	5	macrophage	macrophage	NN
cord-332109-ont0tqpn	229	6	-	-	HYPH
cord-332109-ont0tqpn	229	7	like	like	JJ
cord-332109-ont0tqpn	229	8	cells	cell	NNS
cord-332109-ont0tqpn	229	9	,	,	,
cord-332109-ont0tqpn	229	10	such	such	JJ
cord-332109-ont0tqpn	229	11	as	as	IN
cord-332109-ont0tqpn	229	12	microglia	microglia	NN
cord-332109-ont0tqpn	229	13	,	,	,
cord-332109-ont0tqpn	229	14	from	from	IN
cord-332109-ont0tqpn	229	15	migrating	migrate	VBG
cord-332109-ont0tqpn	229	16	towards	towards	IN
cord-332109-ont0tqpn	229	17	the	the	DT
cord-332109-ont0tqpn	229	18	nodes	node	NNS
cord-332109-ont0tqpn	229	19	of	of	IN
cord-332109-ont0tqpn	229	20	microbial	microbial	JJ
cord-332109-ont0tqpn	229	21	invasions	invasion	NNS
cord-332109-ont0tqpn	229	22	.	.	.
cord-332109-ont0tqpn	230	1	It	-PRON-	PRP
cord-332109-ont0tqpn	230	2	also	also	RB
cord-332109-ont0tqpn	230	3	suppresses	suppress	VBZ
cord-332109-ont0tqpn	230	4	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	230	5	factors	factor	NNS
cord-332109-ont0tqpn	230	6	and	and	CC
cord-332109-ont0tqpn	230	7	promotes	promote	VBZ
cord-332109-ont0tqpn	230	8	anti	anti	JJ
cord-332109-ont0tqpn	230	9	-	-	JJ
cord-332109-ont0tqpn	230	10	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	230	11	activities	activity	NNS
cord-332109-ont0tqpn	230	12	[	[	-LRB-
cord-332109-ont0tqpn	230	13	111	111	CD
cord-332109-ont0tqpn	230	14	]	]	-RRB-
cord-332109-ont0tqpn	230	15	.	.	.
cord-332109-ont0tqpn	231	1	THC	THC	NNP
cord-332109-ont0tqpn	231	2	downregulates	downregulate	VBZ
cord-332109-ont0tqpn	231	3	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	231	4	cytokines	cytokine	NNS
cord-332109-ont0tqpn	231	5	,	,	,
cord-332109-ont0tqpn	231	6	IL-1α	il-1α	NN
cord-332109-ont0tqpn	231	7	,	,	,
cord-332109-ont0tqpn	231	8	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	231	9	,	,	,
cord-332109-ont0tqpn	231	10	and	and	CC
cord-332109-ont0tqpn	231	11	TNFα	TNFα	NNS
cord-332109-ont0tqpn	231	12	.	.	.
cord-332109-ont0tqpn	232	1	By	by	IN
cord-332109-ont0tqpn	232	2	dampening	dampen	VBG
cord-332109-ont0tqpn	232	3	immune	immune	JJ
cord-332109-ont0tqpn	232	4	responses	response	NNS
cord-332109-ont0tqpn	232	5	to	to	IN
cord-332109-ont0tqpn	232	6	invading	invade	VBG
cord-332109-ont0tqpn	232	7	pathogens	pathogen	NNS
cord-332109-ont0tqpn	232	8	,	,	,
cord-332109-ont0tqpn	232	9	THC	THC	NNP
cord-332109-ont0tqpn	232	10	could	could	MD
cord-332109-ont0tqpn	232	11	make	make	VB
cord-332109-ont0tqpn	232	12	the	the	DT
cord-332109-ont0tqpn	232	13	host	host	NN
cord-332109-ont0tqpn	232	14	more	more	RBR
cord-332109-ont0tqpn	232	15	susceptible	susceptible	JJ
cord-332109-ont0tqpn	232	16	to	to	IN
cord-332109-ont0tqpn	232	17	viral	viral	JJ
cord-332109-ont0tqpn	232	18	infections	infection	NNS
cord-332109-ont0tqpn	232	19	,	,	,
cord-332109-ont0tqpn	232	20	such	such	JJ
cord-332109-ont0tqpn	232	21	as	as	IN
cord-332109-ont0tqpn	232	22	HIV-1	HIV-1	NNP
cord-332109-ont0tqpn	232	23	[	[	-LRB-
cord-332109-ont0tqpn	232	24	111	111	CD
cord-332109-ont0tqpn	232	25	]	]	-RRB-
cord-332109-ont0tqpn	232	26	and	and	CC
cord-332109-ont0tqpn	232	27	possibly	possibly	RB
cord-332109-ont0tqpn	232	28	COVID-19	covid-19	VB
cord-332109-ont0tqpn	232	29	.	.	.
cord-332109-ont0tqpn	233	1	Other	other	JJ
cord-332109-ont0tqpn	233	2	harmful	harmful	JJ
cord-332109-ont0tqpn	233	3	effects	effect	NNS
cord-332109-ont0tqpn	233	4	of	of	IN
cord-332109-ont0tqpn	233	5	marijuana	marijuana	NN
cord-332109-ont0tqpn	233	6	include	include	VBP
cord-332109-ont0tqpn	233	7	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	233	8	,	,	,
cord-332109-ont0tqpn	233	9	cerebrovascular	cerebrovascular	JJ
cord-332109-ont0tqpn	233	10	,	,	,
cord-332109-ont0tqpn	233	11	and	and	CC
cord-332109-ont0tqpn	233	12	neurological	neurological	JJ
cord-332109-ont0tqpn	233	13	complications	complication	NNS
cord-332109-ont0tqpn	233	14	,	,	,
cord-332109-ont0tqpn	233	15	such	such	JJ
cord-332109-ont0tqpn	233	16	as	as	IN
cord-332109-ont0tqpn	233	17	stroke	stroke	NN
cord-332109-ont0tqpn	233	18	,	,	,
cord-332109-ont0tqpn	233	19	cognitive	cognitive	JJ
cord-332109-ont0tqpn	233	20	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	233	21	,	,	,
cord-332109-ont0tqpn	233	22	and	and	CC
cord-332109-ont0tqpn	233	23	behavioral	behavioral	JJ
cord-332109-ont0tqpn	233	24	problems	problem	NNS
cord-332109-ont0tqpn	233	25	[	[	-LRB-
cord-332109-ont0tqpn	233	26	112	112	CD
cord-332109-ont0tqpn	233	27	]	]	-RRB-
cord-332109-ont0tqpn	233	28	.	.	.
cord-332109-ont0tqpn	234	1	Some	some	DT
cord-332109-ont0tqpn	234	2	evidence	evidence	NN
cord-332109-ont0tqpn	234	3	suggested	suggest	VBD
cord-332109-ont0tqpn	234	4	a	a	DT
cord-332109-ont0tqpn	234	5	link	link	NN
cord-332109-ont0tqpn	234	6	between	between	IN
cord-332109-ont0tqpn	234	7	smoking	smoking	NN
cord-332109-ont0tqpn	234	8	marijuana	marijuana	NN
cord-332109-ont0tqpn	234	9	and	and	CC
cord-332109-ont0tqpn	234	10	risk	risk	NN
cord-332109-ont0tqpn	234	11	of	of	IN
cord-332109-ont0tqpn	234	12	COPD	COPD	NNP
cord-332109-ont0tqpn	234	13	[	[	-LRB-
cord-332109-ont0tqpn	234	14	113	113	CD
cord-332109-ont0tqpn	234	15	]	]	-RRB-
cord-332109-ont0tqpn	234	16	,	,	,
cord-332109-ont0tqpn	234	17	one	one	CD
cord-332109-ont0tqpn	234	18	of	of	IN
cord-332109-ont0tqpn	234	19	the	the	DT
cord-332109-ont0tqpn	234	20	major	major	JJ
cord-332109-ont0tqpn	234	21	risk	risk	NN
cord-332109-ont0tqpn	234	22	factors	factor	NNS
cord-332109-ont0tqpn	234	23	for	for	IN
cord-332109-ont0tqpn	234	24	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	234	25	complications	complication	NNS
cord-332109-ont0tqpn	234	26	,	,	,
cord-332109-ont0tqpn	234	27	but	but	CC
cord-332109-ont0tqpn	234	28	the	the	DT
cord-332109-ont0tqpn	234	29	risk	risk	NN
cord-332109-ont0tqpn	234	30	is	be	VBZ
cord-332109-ont0tqpn	234	31	only	only	RB
cord-332109-ont0tqpn	234	32	significant	significant	JJ
cord-332109-ont0tqpn	234	33	if	if	IN
cord-332109-ont0tqpn	234	34	the	the	DT
cord-332109-ont0tqpn	234	35	individuals	individual	NNS
cord-332109-ont0tqpn	234	36	also	also	RB
cord-332109-ont0tqpn	234	37	smoked	smoke	VBD
cord-332109-ont0tqpn	234	38	tobacco	tobacco	NN
cord-332109-ont0tqpn	234	39	[	[	-LRB-
cord-332109-ont0tqpn	234	40	114	114	CD
cord-332109-ont0tqpn	234	41	]	]	-RRB-
cord-332109-ont0tqpn	234	42	.	.	.
cord-332109-ont0tqpn	235	1	On	on	IN
cord-332109-ont0tqpn	235	2	the	the	DT
cord-332109-ont0tqpn	235	3	contrary	contrary	NN
cord-332109-ont0tqpn	235	4	,	,	,
cord-332109-ont0tqpn	235	5	a	a	DT
cord-332109-ont0tqpn	235	6	study	study	NN
cord-332109-ont0tqpn	235	7	,	,	,
cord-332109-ont0tqpn	235	8	which	which	WDT
cord-332109-ont0tqpn	235	9	has	have	VBZ
cord-332109-ont0tqpn	235	10	not	not	RB
cord-332109-ont0tqpn	235	11	been	be	VBN
cord-332109-ont0tqpn	235	12	peer	peer	NN
cord-332109-ont0tqpn	235	13	-	-	HYPH
cord-332109-ont0tqpn	235	14	reviewed	review	VBN
cord-332109-ont0tqpn	235	15	at	at	IN
cord-332109-ont0tqpn	235	16	the	the	DT
cord-332109-ont0tqpn	235	17	time	time	NN
cord-332109-ont0tqpn	235	18	of	of	IN
cord-332109-ont0tqpn	235	19	preparation	preparation	NN
cord-332109-ont0tqpn	235	20	of	of	IN
cord-332109-ont0tqpn	235	21	this	this	DT
cord-332109-ont0tqpn	235	22	article	article	NN
cord-332109-ont0tqpn	235	23	,	,	,
cord-332109-ont0tqpn	235	24	showed	show	VBD
cord-332109-ont0tqpn	235	25	the	the	DT
cord-332109-ont0tqpn	235	26	beneficial	beneficial	JJ
cord-332109-ont0tqpn	235	27	effect	effect	NN
cord-332109-ont0tqpn	235	28	of	of	IN
cord-332109-ont0tqpn	235	29	CBD	CBD	NNP
cord-332109-ont0tqpn	235	30	in	in	IN
cord-332109-ont0tqpn	235	31	preventing	prevent	VBG
cord-332109-ont0tqpn	235	32	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	235	33	by	by	IN
cord-332109-ont0tqpn	235	34	modulating	modulate	VBG
cord-332109-ont0tqpn	235	35	ACE2	ACE2	NNP
cord-332109-ont0tqpn	235	36	expression	expression	NN
cord-332109-ont0tqpn	235	37	and	and	CC
cord-332109-ont0tqpn	235	38	downregulating	downregulate	VBG
cord-332109-ont0tqpn	235	39	serine	serine	NN
cord-332109-ont0tqpn	235	40	protease	protease	NN
cord-332109-ont0tqpn	235	41	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	235	42	[	[	-LRB-
cord-332109-ont0tqpn	235	43	115	115	CD
cord-332109-ont0tqpn	235	44	]	]	-RRB-
cord-332109-ont0tqpn	235	45	.	.	.
cord-332109-ont0tqpn	236	1	Opioids	opioid	NNS
cord-332109-ont0tqpn	236	2	,	,	,
cord-332109-ont0tqpn	236	3	including	include	VBG
cord-332109-ont0tqpn	236	4	illegal	illegal	JJ
cord-332109-ont0tqpn	236	5	drug	drug	NN
cord-332109-ont0tqpn	236	6	heroin	heroin	NN
cord-332109-ont0tqpn	236	7	,	,	,
cord-332109-ont0tqpn	236	8	synthetic	synthetic	JJ
cord-332109-ont0tqpn	236	9	drug	drug	NN
cord-332109-ont0tqpn	236	10	fentanyl	fentanyl	NN
cord-332109-ont0tqpn	236	11	,	,	,
cord-332109-ont0tqpn	236	12	prescription	prescription	NN
cord-332109-ont0tqpn	236	13	pain	pain	NN
cord-332109-ont0tqpn	236	14	-	-	HYPH
cord-332109-ont0tqpn	236	15	killing	kill	VBG
cord-332109-ont0tqpn	236	16	drugs	drug	NNS
cord-332109-ont0tqpn	236	17	oxycodone	oxycodone	NN
cord-332109-ont0tqpn	237	1	(	(	-LRB-
cord-332109-ont0tqpn	237	2	OxyContin	OxyContin	NNP
cord-332109-ont0tqpn	237	3	®	®	,
cord-332109-ont0tqpn	237	4	)	)	-RRB-
cord-332109-ont0tqpn	237	5	,	,	,
cord-332109-ont0tqpn	237	6	hydrocodone	hydrocodone	NN
cord-332109-ont0tqpn	237	7	(	(	-LRB-
cord-332109-ont0tqpn	237	8	Vicodin	Vicodin	NNP
cord-332109-ont0tqpn	237	9	®	®	NNP
cord-332109-ont0tqpn	237	10	)	)	-RRB-
cord-332109-ont0tqpn	237	11	,	,	,
cord-332109-ont0tqpn	237	12	codeine	codeine	NN
cord-332109-ont0tqpn	237	13	,	,	,
cord-332109-ont0tqpn	237	14	and	and	CC
cord-332109-ont0tqpn	237	15	morphine	morphine	NN
cord-332109-ont0tqpn	237	16	,	,	,
cord-332109-ont0tqpn	237	17	are	be	VBP
cord-332109-ont0tqpn	237	18	effectors	effector	NNS
cord-332109-ont0tqpn	237	19	on	on	IN
cord-332109-ont0tqpn	237	20	the	the	DT
cord-332109-ont0tqpn	237	21	endocrine	endocrine	NN
cord-332109-ont0tqpn	237	22	system	system	NN
cord-332109-ont0tqpn	237	23	[	[	-LRB-
cord-332109-ont0tqpn	237	24	116	116	CD
cord-332109-ont0tqpn	237	25	]	]	-RRB-
cord-332109-ont0tqpn	237	26	.	.	.
cord-332109-ont0tqpn	238	1	They	-PRON-	PRP
cord-332109-ont0tqpn	238	2	act	act	VBP
cord-332109-ont0tqpn	238	3	as	as	IN
cord-332109-ont0tqpn	238	4	immune	immune	JJ
cord-332109-ont0tqpn	238	5	suppressors	suppressor	NNS
cord-332109-ont0tqpn	238	6	that	that	WDT
cord-332109-ont0tqpn	238	7	impair	impair	VBP
cord-332109-ont0tqpn	238	8	the	the	DT
cord-332109-ont0tqpn	238	9	function	function	NN
cord-332109-ont0tqpn	238	10	of	of	IN
cord-332109-ont0tqpn	238	11	macrophages	macrophage	NNS
cord-332109-ont0tqpn	238	12	,	,	,
cord-332109-ont0tqpn	238	13	natural	natural	JJ
cord-332109-ont0tqpn	238	14	killer	killer	NN
cord-332109-ont0tqpn	238	15	(	(	-LRB-
cord-332109-ont0tqpn	238	16	NK	NK	NNP
cord-332109-ont0tqpn	238	17	)	)	-RRB-
cord-332109-ont0tqpn	238	18	cells	cell	NNS
cord-332109-ont0tqpn	238	19	,	,	,
cord-332109-ont0tqpn	238	20	and	and	CC
cord-332109-ont0tqpn	238	21	T	t	NN
cord-332109-ont0tqpn	238	22	-	-	HYPH
cord-332109-ont0tqpn	238	23	cells	cell	NNS
cord-332109-ont0tqpn	238	24	,	,	,
cord-332109-ont0tqpn	238	25	and	and	CC
cord-332109-ont0tqpn	238	26	are	be	VBP
cord-332109-ont0tqpn	238	27	associated	associate	VBN
cord-332109-ont0tqpn	238	28	with	with	IN
cord-332109-ont0tqpn	238	29	higher	high	JJR
cord-332109-ont0tqpn	238	30	risks	risk	NNS
cord-332109-ont0tqpn	238	31	of	of	IN
cord-332109-ont0tqpn	238	32	infectious	infectious	JJ
cord-332109-ont0tqpn	238	33	diseases	disease	NNS
cord-332109-ont0tqpn	238	34	,	,	,
cord-332109-ont0tqpn	238	35	such	such	JJ
cord-332109-ont0tqpn	238	36	as	as	IN
cord-332109-ont0tqpn	238	37	pneumonia	pneumonia	NN
cord-332109-ont0tqpn	238	38	[	[	-LRB-
cord-332109-ont0tqpn	238	39	117	117	CD
cord-332109-ont0tqpn	238	40	]	]	-RRB-
cord-332109-ont0tqpn	238	41	.	.	.
cord-332109-ont0tqpn	239	1	The	the	DT
cord-332109-ont0tqpn	239	2	endogenous	endogenous	JJ
cord-332109-ont0tqpn	239	3	opioid	opioid	NN
cord-332109-ont0tqpn	239	4	system	system	NN
cord-332109-ont0tqpn	239	5	(	(	-LRB-
cord-332109-ont0tqpn	239	6	EOS	EOS	NNP
cord-332109-ont0tqpn	239	7	)	)	-RRB-
cord-332109-ont0tqpn	239	8	,	,	,
cord-332109-ont0tqpn	239	9	comprising	comprise	VBG
cord-332109-ont0tqpn	239	10	three	three	CD
cord-332109-ont0tqpn	239	11	naturally	naturally	RB
cord-332109-ont0tqpn	239	12	occurring	occur	VBG
cord-332109-ont0tqpn	239	13	opioid	opioid	NN
cord-332109-ont0tqpn	239	14	peptides	peptide	NNS
cord-332109-ont0tqpn	239	15	(	(	-LRB-
cord-332109-ont0tqpn	239	16	β	β	NN
cord-332109-ont0tqpn	239	17	-	-	HYPH
cord-332109-ont0tqpn	239	18	endorphins	endorphin	NNS
cord-332109-ont0tqpn	239	19	,	,	,
cord-332109-ont0tqpn	239	20	dynorphins	dynorphin	NNS
cord-332109-ont0tqpn	239	21	,	,	,
cord-332109-ont0tqpn	239	22	and	and	CC
cord-332109-ont0tqpn	239	23	enkephalins	enkephalins	NNP
cord-332109-ont0tqpn	239	24	)	)	-RRB-
cord-332109-ont0tqpn	239	25	and	and	CC
cord-332109-ont0tqpn	239	26	three	three	CD
cord-332109-ont0tqpn	239	27	classes	class	NNS
cord-332109-ont0tqpn	239	28	of	of	IN
cord-332109-ont0tqpn	239	29	opioid	opioid	JJ
cord-332109-ont0tqpn	239	30	receptors	receptor	NNS
cord-332109-ont0tqpn	239	31	,	,	,
cord-332109-ont0tqpn	239	32	µ	µ	NN
cord-332109-ont0tqpn	239	33	(	(	-LRB-
cord-332109-ont0tqpn	239	34	MOR	MOR	NNP
cord-332109-ont0tqpn	239	35	)	)	-RRB-
cord-332109-ont0tqpn	239	36	,	,	,
cord-332109-ont0tqpn	239	37	δ	δ	FW
cord-332109-ont0tqpn	239	38	(	(	-LRB-
cord-332109-ont0tqpn	239	39	DOR	DOR	NNP
cord-332109-ont0tqpn	239	40	)	)	-RRB-
cord-332109-ont0tqpn	239	41	,	,	,
cord-332109-ont0tqpn	239	42	and	and	CC
cord-332109-ont0tqpn	239	43	k	k	NNP
cord-332109-ont0tqpn	239	44	(	(	-LRB-
cord-332109-ont0tqpn	239	45	KOR	KOR	NNP
cord-332109-ont0tqpn	239	46	)	)	-RRB-
cord-332109-ont0tqpn	239	47	,	,	,
cord-332109-ont0tqpn	239	48	are	be	VBP
cord-332109-ont0tqpn	239	49	tightly	tightly	RB
cord-332109-ont0tqpn	239	50	linked	link	VBN
cord-332109-ont0tqpn	239	51	to	to	IN
cord-332109-ont0tqpn	239	52	substance	substance	NN
cord-332109-ont0tqpn	239	53	abuse	abuse	NN
cord-332109-ont0tqpn	239	54	and	and	CC
cord-332109-ont0tqpn	239	55	the	the	DT
cord-332109-ont0tqpn	239	56	development	development	NN
cord-332109-ont0tqpn	239	57	of	of	IN
cord-332109-ont0tqpn	239	58	addiction	addiction	NN
cord-332109-ont0tqpn	239	59	,	,	,
cord-332109-ont0tqpn	239	60	and	and	CC
cord-332109-ont0tqpn	239	61	are	be	VBP
cord-332109-ont0tqpn	239	62	responsible	responsible	JJ
cord-332109-ont0tqpn	239	63	for	for	IN
cord-332109-ont0tqpn	239	64	systemic	systemic	JJ
cord-332109-ont0tqpn	239	65	infection	infection	NN
cord-332109-ont0tqpn	239	66	[	[	-LRB-
cord-332109-ont0tqpn	239	67	118	118	CD
cord-332109-ont0tqpn	239	68	]	]	-RRB-
cord-332109-ont0tqpn	239	69	.	.	.
cord-332109-ont0tqpn	240	1	Activation	activation	NN
cord-332109-ont0tqpn	240	2	of	of	IN
cord-332109-ont0tqpn	240	3	opioid	opioid	JJ
cord-332109-ont0tqpn	240	4	receptors	receptor	NNS
cord-332109-ont0tqpn	240	5	in	in	IN
cord-332109-ont0tqpn	240	6	the	the	DT
cord-332109-ont0tqpn	240	7	brain	brain	NN
cord-332109-ont0tqpn	240	8	stem	stem	NN
cord-332109-ont0tqpn	240	9	could	could	MD
cord-332109-ont0tqpn	240	10	lead	lead	VB
cord-332109-ont0tqpn	240	11	to	to	IN
cord-332109-ont0tqpn	240	12	respiratory	respiratory	JJ
cord-332109-ont0tqpn	240	13	depression	depression	NN
cord-332109-ont0tqpn	240	14	and	and	CC
cord-332109-ont0tqpn	240	15	overdose	overdose	NN
cord-332109-ont0tqpn	240	16	fatality	fatality	NN
cord-332109-ont0tqpn	240	17	[	[	-LRB-
cord-332109-ont0tqpn	240	18	119	119	CD
cord-332109-ont0tqpn	240	19	]	]	-RRB-
cord-332109-ont0tqpn	240	20	.	.	.
cord-332109-ont0tqpn	241	1	Respiratory	respiratory	JJ
cord-332109-ont0tqpn	241	2	depression	depression	NN
cord-332109-ont0tqpn	241	3	is	be	VBZ
cord-332109-ont0tqpn	241	4	a	a	DT
cord-332109-ont0tqpn	241	5	leading	lead	VBG
cord-332109-ont0tqpn	241	6	factor	factor	NN
cord-332109-ont0tqpn	241	7	to	to	IN
cord-332109-ont0tqpn	241	8	hypoxemia	hypoxemia	NN
cord-332109-ont0tqpn	241	9	in	in	IN
cord-332109-ont0tqpn	241	10	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	241	11	complications	complication	NNS
cord-332109-ont0tqpn	241	12	.	.	.
cord-332109-ont0tqpn	242	1	Morphine	morphine	NN
cord-332109-ont0tqpn	242	2	desensitizes	desensitize	VBZ
cord-332109-ont0tqpn	242	3	the	the	DT
cord-332109-ont0tqpn	242	4	HPA	HPA	NNP
cord-332109-ont0tqpn	242	5	axis	axis	NN
cord-332109-ont0tqpn	242	6	and	and	CC
cord-332109-ont0tqpn	242	7	inhibits	inhibit	VBZ
cord-332109-ont0tqpn	242	8	the	the	DT
cord-332109-ont0tqpn	242	9	release	release	NN
cord-332109-ont0tqpn	242	10	of	of	IN
cord-332109-ont0tqpn	242	11	anti	anti	JJ
cord-332109-ont0tqpn	242	12	-	-	JJ
cord-332109-ont0tqpn	242	13	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	242	14	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	242	15	through	through	IN
cord-332109-ont0tqpn	242	16	potentiating	potentiate	VBG
cord-332109-ont0tqpn	242	17	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	242	18	cytokine	cytokine	NN
cord-332109-ont0tqpn	242	19	,	,	,
cord-332109-ont0tqpn	242	20	IL-1β	il-1β	PDT
cord-332109-ont0tqpn	242	21	[	[	-LRB-
cord-332109-ont0tqpn	242	22	120	120	CD
cord-332109-ont0tqpn	242	23	]	]	-RRB-
cord-332109-ont0tqpn	242	24	.	.	.
cord-332109-ont0tqpn	243	1	Inhibition	inhibition	NN
cord-332109-ont0tqpn	243	2	of	of	IN
cord-332109-ont0tqpn	243	3	endogenous	endogenous	JJ
cord-332109-ont0tqpn	243	4	glucocorticoid	glucocorticoid	NN
cord-332109-ont0tqpn	243	5	and	and	CC
cord-332109-ont0tqpn	243	6	activation	activation	NN
cord-332109-ont0tqpn	243	7	of	of	IN
cord-332109-ont0tqpn	243	8	IL-1β	il-1β	NN
cord-332109-ont0tqpn	243	9	by	by	IN
cord-332109-ont0tqpn	243	10	opioids	opioid	NNS
cord-332109-ont0tqpn	243	11	could	could	MD
cord-332109-ont0tqpn	243	12	significantly	significantly	RB
cord-332109-ont0tqpn	243	13	increase	increase	VB
cord-332109-ont0tqpn	243	14	the	the	DT
cord-332109-ont0tqpn	243	15	severity	severity	NN
cord-332109-ont0tqpn	243	16	and	and	CC
cord-332109-ont0tqpn	243	17	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	243	18	response	response	NN
cord-332109-ont0tqpn	243	19	of	of	IN
cord-332109-ont0tqpn	243	20	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	243	21	in	in	IN
cord-332109-ont0tqpn	243	22	patients	patient	NNS
cord-332109-ont0tqpn	243	23	with	with	IN
cord-332109-ont0tqpn	243	24	OUD	OUD	NNP
cord-332109-ont0tqpn	243	25	.	.	.
cord-332109-ont0tqpn	244	1	It	-PRON-	PRP
cord-332109-ont0tqpn	244	2	has	have	VBZ
cord-332109-ont0tqpn	244	3	been	be	VBN
cord-332109-ont0tqpn	244	4	shown	show	VBN
cord-332109-ont0tqpn	244	5	that	that	IN
cord-332109-ont0tqpn	244	6	individuals	individual	NNS
cord-332109-ont0tqpn	244	7	with	with	IN
cord-332109-ont0tqpn	244	8	OUD	OUD	NNP
cord-332109-ont0tqpn	244	9	are	be	VBP
cord-332109-ont0tqpn	244	10	more	more	RBR
cord-332109-ont0tqpn	244	11	susceptible	susceptible	JJ
cord-332109-ont0tqpn	244	12	to	to	IN
cord-332109-ont0tqpn	244	13	opportunistic	opportunistic	JJ
cord-332109-ont0tqpn	244	14	infections	infection	NNS
cord-332109-ont0tqpn	244	15	[	[	-LRB-
cord-332109-ont0tqpn	244	16	121	121	CD
cord-332109-ont0tqpn	244	17	]	]	-RRB-
cord-332109-ont0tqpn	244	18	,	,	,
cord-332109-ont0tqpn	244	19	disposing	dispose	VBG
cord-332109-ont0tqpn	244	20	these	these	DT
cord-332109-ont0tqpn	244	21	individuals	individual	NNS
cord-332109-ont0tqpn	244	22	at	at	IN
cord-332109-ont0tqpn	244	23	a	a	DT
cord-332109-ont0tqpn	244	24	higher	high	JJR
cord-332109-ont0tqpn	244	25	chance	chance	NN
cord-332109-ont0tqpn	244	26	of	of	IN
cord-332109-ont0tqpn	244	27	contracting	contract	VBG
cord-332109-ont0tqpn	244	28	the	the	DT
cord-332109-ont0tqpn	244	29	virus	virus	NN
cord-332109-ont0tqpn	244	30	in	in	IN
cord-332109-ont0tqpn	244	31	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	244	32	.	.	.
cord-332109-ont0tqpn	245	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	245	2	is	be	VBZ
cord-332109-ont0tqpn	245	3	a	a	DT
cord-332109-ont0tqpn	245	4	potent	potent	JJ
cord-332109-ont0tqpn	245	5	stimulant	stimulant	NN
cord-332109-ont0tqpn	245	6	,	,	,
cord-332109-ont0tqpn	245	7	and	and	CC
cord-332109-ont0tqpn	245	8	is	be	VBZ
cord-332109-ont0tqpn	245	9	the	the	DT
cord-332109-ont0tqpn	245	10	second	second	JJ
cord-332109-ont0tqpn	245	11	most	most	RBS
cord-332109-ont0tqpn	245	12	abused	abused	JJ
cord-332109-ont0tqpn	245	13	illicit	illicit	JJ
cord-332109-ont0tqpn	245	14	drug	drug	NN
cord-332109-ont0tqpn	245	15	after	after	IN
cord-332109-ont0tqpn	245	16	marijuana	marijuana	NN
cord-332109-ont0tqpn	245	17	.	.	.
cord-332109-ont0tqpn	246	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	246	2	can	can	MD
cord-332109-ont0tqpn	246	3	be	be	VB
cord-332109-ont0tqpn	246	4	abused	abuse	VBN
cord-332109-ont0tqpn	246	5	in	in	IN
cord-332109-ont0tqpn	246	6	several	several	JJ
cord-332109-ont0tqpn	246	7	forms	form	NNS
cord-332109-ont0tqpn	246	8	,	,	,
cord-332109-ont0tqpn	246	9	such	such	JJ
cord-332109-ont0tqpn	246	10	as	as	IN
cord-332109-ont0tqpn	246	11	chewing	chew	VBG
cord-332109-ont0tqpn	246	12	the	the	DT
cord-332109-ont0tqpn	246	13	leaves	leave	NNS
cord-332109-ont0tqpn	246	14	of	of	IN
cord-332109-ont0tqpn	246	15	Erythroxylum	Erythroxylum	NNP
cord-332109-ont0tqpn	246	16	coca	coca	NN
cord-332109-ont0tqpn	246	17	tree	tree	NN
cord-332109-ont0tqpn	246	18	,	,	,
cord-332109-ont0tqpn	246	19	injecting	inject	VBG
cord-332109-ont0tqpn	246	20	the	the	DT
cord-332109-ont0tqpn	246	21	water	water	NN
cord-332109-ont0tqpn	246	22	-	-	HYPH
cord-332109-ont0tqpn	246	23	soluble	soluble	JJ
cord-332109-ont0tqpn	246	24	hydrochloride	hydrochloride	NN
cord-332109-ont0tqpn	246	25	salt	salt	NN
cord-332109-ont0tqpn	246	26	form	form	NN
cord-332109-ont0tqpn	246	27	,	,	,
cord-332109-ont0tqpn	246	28	and	and	CC
cord-332109-ont0tqpn	246	29	smoking	smoking	NN
cord-332109-ont0tqpn	246	30	or	or	CC
cord-332109-ont0tqpn	246	31	snorting	snort	VBG
cord-332109-ont0tqpn	246	32	pure	pure	JJ
cord-332109-ont0tqpn	246	33	,	,	,
cord-332109-ont0tqpn	246	34	freebase	freebase	NN
cord-332109-ont0tqpn	246	35	form	form	NN
cord-332109-ont0tqpn	246	36	,	,	,
cord-332109-ont0tqpn	246	37	called	call	VBN
cord-332109-ont0tqpn	246	38	"	"	``
cord-332109-ont0tqpn	246	39	crack	crack	NN
cord-332109-ont0tqpn	246	40	"	"	''
cord-332109-ont0tqpn	246	41	.	.	.
cord-332109-ont0tqpn	247	1	One	one	CD
cord-332109-ont0tqpn	247	2	of	of	IN
cord-332109-ont0tqpn	247	3	the	the	DT
cord-332109-ont0tqpn	247	4	most	most	RBS
cord-332109-ont0tqpn	247	5	significant	significant	JJ
cord-332109-ont0tqpn	247	6	pathophysiological	pathophysiological	JJ
cord-332109-ont0tqpn	247	7	effects	effect	NNS
cord-332109-ont0tqpn	247	8	of	of	IN
cord-332109-ont0tqpn	247	9	cocaine	cocaine	NN
cord-332109-ont0tqpn	247	10	is	be	VBZ
cord-332109-ont0tqpn	247	11	its	-PRON-	PRP$
cord-332109-ont0tqpn	247	12	cardiotoxicity	cardiotoxicity	NN
cord-332109-ont0tqpn	247	13	,	,	,
cord-332109-ont0tqpn	247	14	which	which	WDT
cord-332109-ont0tqpn	247	15	has	have	VBZ
cord-332109-ont0tqpn	247	16	been	be	VBN
cord-332109-ont0tqpn	247	17	well	well	RB
cord-332109-ont0tqpn	247	18	documented	document	VBN
cord-332109-ont0tqpn	247	19	and	and	CC
cord-332109-ont0tqpn	247	20	extensively	extensively	RB
cord-332109-ont0tqpn	247	21	reviewed	review	VBD
cord-332109-ont0tqpn	247	22	[	[	-LRB-
cord-332109-ont0tqpn	247	23	122	122	CD
cord-332109-ont0tqpn	247	24	]	]	-RRB-
cord-332109-ont0tqpn	247	25	[	[	-LRB-
cord-332109-ont0tqpn	247	26	123	123	CD
cord-332109-ont0tqpn	247	27	]	]	-RRB-
cord-332109-ont0tqpn	247	28	[	[	-LRB-
cord-332109-ont0tqpn	247	29	124	124	CD
cord-332109-ont0tqpn	247	30	]	]	-RRB-
cord-332109-ont0tqpn	247	31	[	[	-LRB-
cord-332109-ont0tqpn	247	32	125	125	CD
cord-332109-ont0tqpn	247	33	]	]	-RRB-
cord-332109-ont0tqpn	247	34	[	[	-LRB-
cord-332109-ont0tqpn	247	35	126	126	CD
cord-332109-ont0tqpn	247	36	]	]	-RRB-
cord-332109-ont0tqpn	247	37	.	.	.
cord-332109-ont0tqpn	248	1	Cardiac	cardiac	JJ
cord-332109-ont0tqpn	248	2	arrhythmias	arrhythmia	NNS
cord-332109-ont0tqpn	248	3	and	and	CC
cord-332109-ont0tqpn	248	4	acute	acute	JJ
cord-332109-ont0tqpn	248	5	myocardial	myocardial	JJ
cord-332109-ont0tqpn	248	6	ischemia	ischemia	NN
cord-332109-ont0tqpn	248	7	or	or	CC
cord-332109-ont0tqpn	248	8	infarction	infarction	NN
cord-332109-ont0tqpn	248	9	(	(	-LRB-
cord-332109-ont0tqpn	248	10	MI	MI	NNP
cord-332109-ont0tqpn	248	11	)	)	-RRB-
cord-332109-ont0tqpn	248	12	are	be	VBP
cord-332109-ont0tqpn	248	13	the	the	DT
cord-332109-ont0tqpn	248	14	leading	lead	VBG
cord-332109-ont0tqpn	248	15	causes	cause	NNS
cord-332109-ont0tqpn	248	16	of	of	IN
cord-332109-ont0tqpn	248	17	cocaine	cocaine	NN
cord-332109-ont0tqpn	248	18	-	-	HYPH
cord-332109-ont0tqpn	248	19	induced	induce	VBN
cord-332109-ont0tqpn	248	20	sudden	sudden	JJ
cord-332109-ont0tqpn	248	21	cardiac	cardiac	JJ
cord-332109-ont0tqpn	248	22	death	death	NN
cord-332109-ont0tqpn	248	23	.	.	.
cord-332109-ont0tqpn	249	1	Other	other	JJ
cord-332109-ont0tqpn	249	2	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	249	3	diseases	disease	NNS
cord-332109-ont0tqpn	249	4	associated	associate	VBN
cord-332109-ont0tqpn	249	5	with	with	IN
cord-332109-ont0tqpn	249	6	cocaine	cocaine	NN
cord-332109-ont0tqpn	249	7	include	include	VBP
cord-332109-ont0tqpn	249	8	heart	heart	NN
cord-332109-ont0tqpn	249	9	failure	failure	NN
cord-332109-ont0tqpn	249	10	,	,	,
cord-332109-ont0tqpn	249	11	cardiomyopathies	cardiomyopathy	NNS
cord-332109-ont0tqpn	249	12	,	,	,
cord-332109-ont0tqpn	249	13	aortic	aortic	JJ
cord-332109-ont0tqpn	249	14	dissection	dissection	NN
cord-332109-ont0tqpn	249	15	,	,	,
cord-332109-ont0tqpn	249	16	and	and	CC
cord-332109-ont0tqpn	249	17	endocarditis	endocarditis	NN
cord-332109-ont0tqpn	249	18	.	.	.
cord-332109-ont0tqpn	250	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	250	2	blocks	block	VBZ
cord-332109-ont0tqpn	251	1	voltage	voltage	VB
cord-332109-ont0tqpn	251	2	-	-	HYPH
cord-332109-ont0tqpn	251	3	dependent	dependent	JJ
cord-332109-ont0tqpn	251	4	Na	Na	NNP
cord-332109-ont0tqpn	252	1	+	+	UH
cord-332109-ont0tqpn	252	2	and	and	CC
cord-332109-ont0tqpn	252	3	K	K	NNP
cord-332109-ont0tqpn	252	4	+	+	CC
cord-332109-ont0tqpn	252	5	channels	channel	NNS
cord-332109-ont0tqpn	252	6	in	in	IN
cord-332109-ont0tqpn	252	7	the	the	DT
cord-332109-ont0tqpn	252	8	sinoatrial	sinoatrial	NN
cord-332109-ont0tqpn	252	9	node	node	NN
cord-332109-ont0tqpn	252	10	and	and	CC
cord-332109-ont0tqpn	252	11	the	the	DT
cord-332109-ont0tqpn	252	12	myocardium	myocardium	NN
cord-332109-ont0tqpn	252	13	,	,	,
cord-332109-ont0tqpn	252	14	depressing	depress	VBG
cord-332109-ont0tqpn	252	15	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	252	16	contractility	contractility	NN
cord-332109-ont0tqpn	252	17	[	[	-LRB-
cord-332109-ont0tqpn	252	18	127	127	CD
cord-332109-ont0tqpn	252	19	]	]	-RRB-
cord-332109-ont0tqpn	252	20	.	.	.
cord-332109-ont0tqpn	253	1	Due	due	IN
cord-332109-ont0tqpn	253	2	to	to	IN
cord-332109-ont0tqpn	253	3	its	-PRON-	PRP$
cord-332109-ont0tqpn	253	4	function	function	NN
cord-332109-ont0tqpn	253	5	as	as	IN
cord-332109-ont0tqpn	253	6	an	an	DT
cord-332109-ont0tqpn	253	7	ion	ion	NN
cord-332109-ont0tqpn	253	8	channel	channel	NN
cord-332109-ont0tqpn	253	9	blocker	blocker	NN
cord-332109-ont0tqpn	253	10	,	,	,
cord-332109-ont0tqpn	253	11	cocaine	cocaine	NN
cord-332109-ont0tqpn	253	12	has	have	VBZ
cord-332109-ont0tqpn	253	13	been	be	VBN
cord-332109-ont0tqpn	253	14	effectively	effectively	RB
cord-332109-ont0tqpn	253	15	used	use	VBN
cord-332109-ont0tqpn	253	16	as	as	IN
cord-332109-ont0tqpn	253	17	a	a	DT
cord-332109-ont0tqpn	253	18	local	local	JJ
cord-332109-ont0tqpn	253	19	anesthetic	anesthetic	NN
cord-332109-ont0tqpn	253	20	[	[	-LRB-
cord-332109-ont0tqpn	253	21	128	128	CD
cord-332109-ont0tqpn	253	22	]	]	-RRB-
cord-332109-ont0tqpn	253	23	.	.	.
cord-332109-ont0tqpn	254	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	254	2	can	can	MD
cord-332109-ont0tqpn	254	3	also	also	RB
cord-332109-ont0tqpn	254	4	induce	induce	VB
cord-332109-ont0tqpn	254	5	binding	binding	NN
cord-332109-ont0tqpn	254	6	and	and	CC
cord-332109-ont0tqpn	254	7	opening	opening	NN
cord-332109-ont0tqpn	254	8	of	of	IN
cord-332109-ont0tqpn	254	9	L	l	NN
cord-332109-ont0tqpn	254	10	-	-	HYPH
cord-332109-ont0tqpn	254	11	type	type	NN
cord-332109-ont0tqpn	255	1	Ca	ca	NN
cord-332109-ont0tqpn	255	2	2	2	CD
cord-332109-ont0tqpn	255	3	+	+	SYM
cord-332109-ont0tqpn	255	4	channels	channel	NNS
cord-332109-ont0tqpn	255	5	,	,	,
cord-332109-ont0tqpn	255	6	causing	cause	VBG
cord-332109-ont0tqpn	255	7	the	the	DT
cord-332109-ont0tqpn	255	8	influx	influx	NN
cord-332109-ont0tqpn	255	9	of	of	IN
cord-332109-ont0tqpn	255	10	Ca	Ca	NNP
cord-332109-ont0tqpn	255	11	2	2	CD
cord-332109-ont0tqpn	255	12	+	+	CC
cord-332109-ont0tqpn	255	13	in	in	IN
cord-332109-ont0tqpn	255	14	cardiomyocytes	cardiomyocyte	NNS
cord-332109-ont0tqpn	255	15	and	and	CC
cord-332109-ont0tqpn	255	16	elevation	elevation	NN
cord-332109-ont0tqpn	255	17	of	of	IN
cord-332109-ont0tqpn	255	18	intracellular	intracellular	JJ
cord-332109-ont0tqpn	255	19	Ca	Ca	NNP
cord-332109-ont0tqpn	255	20	2	2	CD
cord-332109-ont0tqpn	255	21	+	+	CC
cord-332109-ont0tqpn	255	22	concentration	concentration	NN
cord-332109-ont0tqpn	255	23	.	.	.
cord-332109-ont0tqpn	256	1	This	this	DT
cord-332109-ont0tqpn	256	2	second	second	JJ
cord-332109-ont0tqpn	256	3	messenger	messenger	NN
cord-332109-ont0tqpn	256	4	pathway	pathway	NN
cord-332109-ont0tqpn	256	5	may	may	MD
cord-332109-ont0tqpn	256	6	also	also	RB
cord-332109-ont0tqpn	256	7	lead	lead	VB
cord-332109-ont0tqpn	256	8	to	to	IN
cord-332109-ont0tqpn	256	9	cardiac	cardiac	JJ
cord-332109-ont0tqpn	256	10	arrhythmia	arrhythmia	NN
cord-332109-ont0tqpn	256	11	[	[	-LRB-
cord-332109-ont0tqpn	256	12	129	129	CD
cord-332109-ont0tqpn	256	13	]	]	-RRB-
cord-332109-ont0tqpn	256	14	.	.	.
cord-332109-ont0tqpn	257	1	Clinically	clinically	RB
cord-332109-ont0tqpn	257	2	,	,	,
cord-332109-ont0tqpn	257	3	cocaine	cocaine	NN
cord-332109-ont0tqpn	257	4	increases	increase	VBZ
cord-332109-ont0tqpn	257	5	myocardial	myocardial	JJ
cord-332109-ont0tqpn	257	6	oxygen	oxygen	NN
cord-332109-ont0tqpn	257	7	demand	demand	NN
cord-332109-ont0tqpn	257	8	by	by	IN
cord-332109-ont0tqpn	257	9	increasing	increase	VBG
cord-332109-ont0tqpn	257	10	heart	heart	NN
cord-332109-ont0tqpn	257	11	rate	rate	NN
cord-332109-ont0tqpn	257	12	and	and	CC
cord-332109-ont0tqpn	257	13	hypertension	hypertension	NN
cord-332109-ont0tqpn	257	14	,	,	,
cord-332109-ont0tqpn	257	15	while	while	IN
cord-332109-ont0tqpn	257	16	it	-PRON-	PRP
cord-332109-ont0tqpn	257	17	decreases	decrease	VBZ
cord-332109-ont0tqpn	257	18	the	the	DT
cord-332109-ont0tqpn	257	19	oxygen	oxygen	NN
cord-332109-ont0tqpn	257	20	supply	supply	NN
cord-332109-ont0tqpn	257	21	due	due	IN
cord-332109-ont0tqpn	257	22	to	to	IN
cord-332109-ont0tqpn	257	23	coronary	coronary	JJ
cord-332109-ont0tqpn	257	24	vasoconstriction	vasoconstriction	NN
cord-332109-ont0tqpn	257	25	[	[	-LRB-
cord-332109-ont0tqpn	257	26	130	130	CD
cord-332109-ont0tqpn	257	27	]	]	-RRB-
cord-332109-ont0tqpn	258	1	[	[	-LRB-
cord-332109-ont0tqpn	258	2	131	131	CD
cord-332109-ont0tqpn	258	3	]	]	-RRB-
cord-332109-ont0tqpn	258	4	[	[	-LRB-
cord-332109-ont0tqpn	258	5	132	132	CD
cord-332109-ont0tqpn	258	6	]	]	-RRB-
cord-332109-ont0tqpn	258	7	.	.	.
cord-332109-ont0tqpn	259	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	259	2	impairs	impair	VBZ
cord-332109-ont0tqpn	259	3	endothelial	endothelial	JJ
cord-332109-ont0tqpn	259	4	functions	function	NNS
cord-332109-ont0tqpn	259	5	[	[	-LRB-
cord-332109-ont0tqpn	259	6	133	133	CD
cord-332109-ont0tqpn	259	7	]	]	-RRB-
cord-332109-ont0tqpn	260	1	,	,	,
cord-332109-ont0tqpn	260	2	sensitizes	sensitize	VBZ
cord-332109-ont0tqpn	260	3	constrictor	constrictor	NN
cord-332109-ont0tqpn	260	4	effects	effect	NNS
cord-332109-ont0tqpn	260	5	of	of	IN
cord-332109-ont0tqpn	260	6	catecholamines	catecholamine	NNS
cord-332109-ont0tqpn	260	7	[	[	-LRB-
cord-332109-ont0tqpn	260	8	134	134	CD
cord-332109-ont0tqpn	260	9	]	]	-RRB-
cord-332109-ont0tqpn	260	10	,	,	,
cord-332109-ont0tqpn	260	11	and	and	CC
cord-332109-ont0tqpn	260	12	causes	cause	VBZ
cord-332109-ont0tqpn	260	13	microvascular	microvascular	JJ
cord-332109-ont0tqpn	260	14	diseases	disease	NNS
cord-332109-ont0tqpn	260	15	and	and	CC
cord-332109-ont0tqpn	260	16	thrombosis	thrombosis	NN
cord-332109-ont0tqpn	260	17	[	[	-LRB-
cord-332109-ont0tqpn	260	18	135	135	CD
cord-332109-ont0tqpn	260	19	,	,	,
cord-332109-ont0tqpn	260	20	136	136	CD
cord-332109-ont0tqpn	260	21	]	]	-RRB-
cord-332109-ont0tqpn	260	22	.	.	.
cord-332109-ont0tqpn	261	1	The	the	DT
cord-332109-ont0tqpn	261	2	cocaine	cocaine	NN
cord-332109-ont0tqpn	261	3	-	-	HYPH
cord-332109-ont0tqpn	261	4	mediated	mediate	VBN
cord-332109-ont0tqpn	261	5	oxygen	oxygen	NN
cord-332109-ont0tqpn	261	6	imbalance	imbalance	NN
cord-332109-ont0tqpn	261	7	can	can	MD
cord-332109-ont0tqpn	261	8	be	be	VB
cord-332109-ont0tqpn	261	9	particularly	particularly	RB
cord-332109-ont0tqpn	261	10	detrimental	detrimental	JJ
cord-332109-ont0tqpn	261	11	in	in	IN
cord-332109-ont0tqpn	261	12	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	261	13	,	,	,
cord-332109-ont0tqpn	261	14	in	in	IN
cord-332109-ont0tqpn	261	15	which	which	WDT
cord-332109-ont0tqpn	261	16	the	the	DT
cord-332109-ont0tqpn	261	17	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	261	18	can	can	MD
cord-332109-ont0tqpn	261	19	cause	cause	VB
cord-332109-ont0tqpn	261	20	hypoxemia	hypoxemia	NN
cord-332109-ont0tqpn	261	21	because	because	IN
cord-332109-ont0tqpn	261	22	of	of	IN
cord-332109-ont0tqpn	261	23	the	the	DT
cord-332109-ont0tqpn	261	24	diminishing	diminishing	NN
cord-332109-ont0tqpn	261	25	of	of	IN
cord-332109-ont0tqpn	261	26	lung	lung	NN
cord-332109-ont0tqpn	261	27	capacity	capacity	NN
cord-332109-ont0tqpn	261	28	.	.	.
cord-332109-ont0tqpn	262	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	262	2	exerts	exert	VBZ
cord-332109-ont0tqpn	262	3	its	-PRON-	PRP$
cord-332109-ont0tqpn	262	4	effect	effect	NN
cord-332109-ont0tqpn	262	5	through	through	IN
cord-332109-ont0tqpn	262	6	binding	bind	VBG
cord-332109-ont0tqpn	262	7	to	to	IN
cord-332109-ont0tqpn	262	8	three	three	CD
cord-332109-ont0tqpn	262	9	monoamine	monoamine	NN
cord-332109-ont0tqpn	262	10	transporters	transporter	NNS
cord-332109-ont0tqpn	262	11	on	on	IN
cord-332109-ont0tqpn	262	12	nerve	nerve	NN
cord-332109-ont0tqpn	262	13	terminals	terminal	NNS
cord-332109-ont0tqpn	262	14	:	:	:
cord-332109-ont0tqpn	262	15	the	the	DT
cord-332109-ont0tqpn	262	16	serotonin	serotonin	NN
cord-332109-ont0tqpn	262	17	transporter	transporter	NN
cord-332109-ont0tqpn	262	18	(	(	-LRB-
cord-332109-ont0tqpn	262	19	SERT	SERT	NNP
cord-332109-ont0tqpn	262	20	)	)	-RRB-
cord-332109-ont0tqpn	262	21	,	,	,
cord-332109-ont0tqpn	262	22	the	the	DT
cord-332109-ont0tqpn	262	23	dopamine	dopamine	NN
cord-332109-ont0tqpn	262	24	transporter	transporter	NN
cord-332109-ont0tqpn	262	25	(	(	-LRB-
cord-332109-ont0tqpn	262	26	DAT	DAT	NNP
cord-332109-ont0tqpn	262	27	)	)	-RRB-
cord-332109-ont0tqpn	262	28	,	,	,
cord-332109-ont0tqpn	262	29	and	and	CC
cord-332109-ont0tqpn	262	30	the	the	DT
cord-332109-ont0tqpn	262	31	norepinephrine	norepinephrine	NN
cord-332109-ont0tqpn	262	32	transporter	transporter	NN
cord-332109-ont0tqpn	262	33	(	(	-LRB-
cord-332109-ont0tqpn	262	34	NET	NET	NNP
cord-332109-ont0tqpn	262	35	)	)	-RRB-
cord-332109-ont0tqpn	262	36	,	,	,
cord-332109-ont0tqpn	262	37	with	with	IN
cord-332109-ont0tqpn	262	38	K	K	NNP
cord-332109-ont0tqpn	262	39	i	i	PRP
cord-332109-ont0tqpn	262	40	of	of	IN
cord-332109-ont0tqpn	262	41	0.14	0.14	CD
cord-332109-ont0tqpn	262	42	,	,	,
cord-332109-ont0tqpn	262	43	0.64	0.64	CD
cord-332109-ont0tqpn	262	44	,	,	,
cord-332109-ont0tqpn	262	45	and	and	CC
cord-332109-ont0tqpn	262	46	1.6	1.6	CD
cord-332109-ont0tqpn	262	47	µM	µM	NNS
cord-332109-ont0tqpn	262	48	,	,	,
cord-332109-ont0tqpn	262	49	respectively	respectively	RB
cord-332109-ont0tqpn	262	50	[	[	-LRB-
cord-332109-ont0tqpn	262	51	137	137	CD
cord-332109-ont0tqpn	262	52	]	]	-RRB-
cord-332109-ont0tqpn	262	53	.	.	.
cord-332109-ont0tqpn	263	1	Upon	upon	IN
cord-332109-ont0tqpn	263	2	binding	bind	VBG
cord-332109-ont0tqpn	263	3	to	to	IN
cord-332109-ont0tqpn	263	4	these	these	DT
cord-332109-ont0tqpn	263	5	transporters	transporter	NNS
cord-332109-ont0tqpn	263	6	,	,	,
cord-332109-ont0tqpn	263	7	cocaine	cocaine	NN
cord-332109-ont0tqpn	263	8	inhibits	inhibit	VBZ
cord-332109-ont0tqpn	263	9	the	the	DT
cord-332109-ont0tqpn	263	10	reuptake	reuptake	NN
cord-332109-ont0tqpn	263	11	of	of	IN
cord-332109-ont0tqpn	263	12	the	the	DT
cord-332109-ont0tqpn	263	13	neurotransmitters	neurotransmitter	NNS
cord-332109-ont0tqpn	263	14	from	from	IN
cord-332109-ont0tqpn	263	15	the	the	DT
cord-332109-ont0tqpn	263	16	synaptic	synaptic	JJ
cord-332109-ont0tqpn	263	17	cleft	cleft	NN
cord-332109-ont0tqpn	263	18	,	,	,
cord-332109-ont0tqpn	263	19	leading	lead	VBG
cord-332109-ont0tqpn	263	20	to	to	IN
cord-332109-ont0tqpn	263	21	prolonged	prolong	VBN
cord-332109-ont0tqpn	263	22	synapses	synapsis	NNS
cord-332109-ont0tqpn	263	23	and	and	CC
cord-332109-ont0tqpn	263	24	activation	activation	NN
cord-332109-ont0tqpn	263	25	of	of	IN
cord-332109-ont0tqpn	263	26	postsynaptic	postsynaptic	JJ
cord-332109-ont0tqpn	263	27	receptors	receptor	NNS
cord-332109-ont0tqpn	263	28	.	.	.
cord-332109-ont0tqpn	264	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	264	2	also	also	RB
cord-332109-ont0tqpn	264	3	binds	bind	VBZ
cord-332109-ont0tqpn	264	4	directly	directly	RB
cord-332109-ont0tqpn	264	5	to	to	IN
cord-332109-ont0tqpn	264	6	two	two	CD
cord-332109-ont0tqpn	264	7	classes	class	NNS
cord-332109-ont0tqpn	264	8	of	of	IN
cord-332109-ont0tqpn	264	9	neurotransmitter	neurotransmitter	NN
cord-332109-ont0tqpn	264	10	receptors	receptor	NNS
cord-332109-ont0tqpn	264	11	,	,	,
cord-332109-ont0tqpn	264	12	muscarinic	muscarinic	JJ
cord-332109-ont0tqpn	264	13	acetylcholine	acetylcholine	NN
cord-332109-ont0tqpn	264	14	and	and	CC
cord-332109-ont0tqpn	264	15	sigma	sigma	NNP
cord-332109-ont0tqpn	264	16	receptors	receptor	NNS
cord-332109-ont0tqpn	264	17	[	[	-LRB-
cord-332109-ont0tqpn	264	18	138	138	CD
cord-332109-ont0tqpn	264	19	]	]	-RRB-
cord-332109-ont0tqpn	264	20	[	[	-LRB-
cord-332109-ont0tqpn	264	21	139	139	CD
cord-332109-ont0tqpn	264	22	]	]	-RRB-
cord-332109-ont0tqpn	264	23	[	[	-LRB-
cord-332109-ont0tqpn	264	24	140	140	CD
cord-332109-ont0tqpn	264	25	]	]	-RRB-
cord-332109-ont0tqpn	264	26	.	.	.
cord-332109-ont0tqpn	265	1	The	the	DT
cord-332109-ont0tqpn	265	2	interactions	interaction	NNS
cord-332109-ont0tqpn	265	3	with	with	IN
cord-332109-ont0tqpn	265	4	the	the	DT
cord-332109-ont0tqpn	265	5	transporters	transporter	NNS
cord-332109-ont0tqpn	265	6	and	and	CC
cord-332109-ont0tqpn	265	7	the	the	DT
cord-332109-ont0tqpn	265	8	receptors	receptor	NNS
cord-332109-ont0tqpn	265	9	form	form	VBP
cord-332109-ont0tqpn	265	10	the	the	DT
cord-332109-ont0tqpn	265	11	molecular	molecular	JJ
cord-332109-ont0tqpn	265	12	basis	basis	NN
cord-332109-ont0tqpn	265	13	for	for	IN
cord-332109-ont0tqpn	265	14	cocaine	cocaine	NN
cord-332109-ont0tqpn	265	15	neurotoxicity	neurotoxicity	NN
cord-332109-ont0tqpn	265	16	.	.	.
cord-332109-ont0tqpn	266	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	266	2	stimulates	stimulate	VBZ
cord-332109-ont0tqpn	266	3	the	the	DT
cord-332109-ont0tqpn	266	4	HPA	HPA	NNP
cord-332109-ont0tqpn	266	5	axis	axis	NN
cord-332109-ont0tqpn	266	6	,	,	,
cord-332109-ont0tqpn	266	7	increasing	increase	VBG
cord-332109-ont0tqpn	266	8	the	the	DT
cord-332109-ont0tqpn	266	9	secretion	secretion	NN
cord-332109-ont0tqpn	266	10	of	of	IN
cord-332109-ont0tqpn	266	11	neuronal	neuronal	JJ
cord-332109-ont0tqpn	266	12	peptide	peptide	NN
cord-332109-ont0tqpn	266	13	CRH	crh	NN
cord-332109-ont0tqpn	266	14	,	,	,
cord-332109-ont0tqpn	266	15	which	which	WDT
cord-332109-ont0tqpn	266	16	leads	lead	VBZ
cord-332109-ont0tqpn	266	17	to	to	IN
cord-332109-ont0tqpn	266	18	subsequent	subsequent	JJ
cord-332109-ont0tqpn	266	19	releasing	releasing	NN
cord-332109-ont0tqpn	266	20	of	of	IN
cord-332109-ont0tqpn	266	21	β	β	NN
cord-332109-ont0tqpn	266	22	-	-	HYPH
cord-332109-ont0tqpn	266	23	endorphin	endorphin	NN
cord-332109-ont0tqpn	266	24	and	and	CC
cord-332109-ont0tqpn	266	25	ACTH	ACTH	NNP
cord-332109-ont0tqpn	266	26	.	.	.
cord-332109-ont0tqpn	267	1	Through	through	IN
cord-332109-ont0tqpn	267	2	general	general	JJ
cord-332109-ont0tqpn	267	3	circulation	circulation	NN
cord-332109-ont0tqpn	267	4	,	,	,
cord-332109-ont0tqpn	267	5	ACTH	ACTH	NNP
cord-332109-ont0tqpn	267	6	reaches	reach	VBZ
cord-332109-ont0tqpn	267	7	the	the	DT
cord-332109-ont0tqpn	267	8	adrenal	adrenal	JJ
cord-332109-ont0tqpn	267	9	glands	gland	NNS
cord-332109-ont0tqpn	267	10	and	and	CC
cord-332109-ont0tqpn	267	11	promotes	promote	VBZ
cord-332109-ont0tqpn	267	12	the	the	DT
cord-332109-ont0tqpn	267	13	biosynthesis	biosynthesis	NN
cord-332109-ont0tqpn	267	14	of	of	IN
cord-332109-ont0tqpn	267	15	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	267	16	[	[	-LRB-
cord-332109-ont0tqpn	267	17	141	141	CD
cord-332109-ont0tqpn	267	18	]	]	-RRB-
cord-332109-ont0tqpn	267	19	.	.	.
cord-332109-ont0tqpn	268	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	268	2	-	-	HYPH
cord-332109-ont0tqpn	268	3	induced	induce	VBN
cord-332109-ont0tqpn	268	4	stimulation	stimulation	NN
cord-332109-ont0tqpn	268	5	of	of	IN
cord-332109-ont0tqpn	268	6	the	the	DT
cord-332109-ont0tqpn	268	7	HPA	HPA	NNP
cord-332109-ont0tqpn	268	8	axis	axis	NN
cord-332109-ont0tqpn	268	9	and	and	CC
cord-332109-ont0tqpn	268	10	immune	immune	JJ
cord-332109-ont0tqpn	268	11	suppression	suppression	NN
cord-332109-ont0tqpn	268	12	can	can	MD
cord-332109-ont0tqpn	268	13	alter	alter	VB
cord-332109-ont0tqpn	268	14	antibody	antibody	NN
cord-332109-ont0tqpn	268	15	formation	formation	NN
cord-332109-ont0tqpn	268	16	,	,	,
cord-332109-ont0tqpn	268	17	lymphocyte	lymphocyte	NN
cord-332109-ont0tqpn	268	18	subset	subset	VBN
cord-332109-ont0tqpn	268	19	profile	profile	NN
cord-332109-ont0tqpn	268	20	,	,	,
cord-332109-ont0tqpn	268	21	and	and	CC
cord-332109-ont0tqpn	268	22	lymphocyte	lymphocyte	NN
cord-332109-ont0tqpn	268	23	proliferation	proliferation	NN
cord-332109-ont0tqpn	268	24	.	.	.
cord-332109-ont0tqpn	269	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	269	2	suppresses	suppress	VBZ
cord-332109-ont0tqpn	269	3	responses	response	NNS
cord-332109-ont0tqpn	269	4	to	to	IN
cord-332109-ont0tqpn	269	5	the	the	DT
cord-332109-ont0tqpn	269	6	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	269	7	cytokine	cytokine	NN
cord-332109-ont0tqpn	269	8	,	,	,
cord-332109-ont0tqpn	269	9	IL-6	IL-6	NNP
cord-332109-ont0tqpn	269	10	,	,	,
cord-332109-ont0tqpn	269	11	and	and	CC
cord-332109-ont0tqpn	269	12	dampens	dampen	VBZ
cord-332109-ont0tqpn	269	13	cytotoxic	cytotoxic	JJ
cord-332109-ont0tqpn	269	14	activation	activation	NN
cord-332109-ont0tqpn	269	15	of	of	IN
cord-332109-ont0tqpn	269	16	macrophages	macrophage	NNS
cord-332109-ont0tqpn	269	17	,	,	,
cord-332109-ont0tqpn	269	18	natural	natural	JJ
cord-332109-ont0tqpn	269	19	killer	killer	NN
cord-332109-ont0tqpn	269	20	cells	cell	NNS
cord-332109-ont0tqpn	269	21	,	,	,
cord-332109-ont0tqpn	269	22	and	and	CC
cord-332109-ont0tqpn	269	23	cytotoxic	cytotoxic	JJ
cord-332109-ont0tqpn	269	24	T	t	NN
cord-332109-ont0tqpn	269	25	lymphocytes	lymphocyte	NNS
cord-332109-ont0tqpn	269	26	[	[	-LRB-
cord-332109-ont0tqpn	269	27	142	142	CD
cord-332109-ont0tqpn	269	28	]	]	-RRB-
cord-332109-ont0tqpn	269	29	.	.	.
cord-332109-ont0tqpn	270	1	Due	due	IN
cord-332109-ont0tqpn	270	2	to	to	IN
cord-332109-ont0tqpn	270	3	compromised	compromised	JJ
cord-332109-ont0tqpn	270	4	immune	immune	JJ
cord-332109-ont0tqpn	270	5	responses	response	NNS
cord-332109-ont0tqpn	270	6	,	,	,
cord-332109-ont0tqpn	270	7	cocaine	cocaine	NN
cord-332109-ont0tqpn	270	8	abusers	abuser	NNS
cord-332109-ont0tqpn	270	9	have	have	VBP
cord-332109-ont0tqpn	270	10	considerably	considerably	RB
cord-332109-ont0tqpn	270	11	high	high	JJ
cord-332109-ont0tqpn	270	12	incidences	incidence	NNS
cord-332109-ont0tqpn	270	13	of	of	IN
cord-332109-ont0tqpn	270	14	viral	viral	JJ
cord-332109-ont0tqpn	270	15	infections	infection	NNS
cord-332109-ont0tqpn	270	16	,	,	,
cord-332109-ont0tqpn	270	17	including	include	VBG
cord-332109-ont0tqpn	270	18	human	human	JJ
cord-332109-ont0tqpn	270	19	immunodeficiency	immunodeficiency	NN
cord-332109-ont0tqpn	270	20	virus	virus	NN
cord-332109-ont0tqpn	270	21	(	(	-LRB-
cord-332109-ont0tqpn	270	22	HIV	HIV	NNP
cord-332109-ont0tqpn	270	23	)	)	-RRB-
cord-332109-ont0tqpn	270	24	,	,	,
cord-332109-ont0tqpn	270	25	influenza	influenza	NN
cord-332109-ont0tqpn	270	26	,	,	,
cord-332109-ont0tqpn	270	27	and	and	CC
cord-332109-ont0tqpn	270	28	potentially	potentially	RB
cord-332109-ont0tqpn	270	29	SARS	SARS	NNP
cord-332109-ont0tqpn	270	30	-	-	HYPH
cord-332109-ont0tqpn	270	31	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	270	32	.	.	.
cord-332109-ont0tqpn	271	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	271	2	can	can	MD
cord-332109-ont0tqpn	271	3	induce	induce	VB
cord-332109-ont0tqpn	271	4	BBB	BBB	NNP
cord-332109-ont0tqpn	271	5	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	271	6	,	,	,
cord-332109-ont0tqpn	271	7	disrupt	disrupt	VB
cord-332109-ont0tqpn	271	8	neurovascular	neurovascular	JJ
cord-332109-ont0tqpn	271	9	capillaries	capillary	NNS
cord-332109-ont0tqpn	271	10	and	and	CC
cord-332109-ont0tqpn	271	11	basement	basement	NN
cord-332109-ont0tqpn	271	12	membrane	membrane	NN
cord-332109-ont0tqpn	271	13	[	[	-LRB-
cord-332109-ont0tqpn	271	14	143	143	CD
cord-332109-ont0tqpn	271	15	]	]	-RRB-
cord-332109-ont0tqpn	271	16	,	,	,
cord-332109-ont0tqpn	271	17	and	and	CC
cord-332109-ont0tqpn	271	18	increase	increase	VB
cord-332109-ont0tqpn	271	19	BBB	bbb	NN
cord-332109-ont0tqpn	271	20	permeability	permeability	NN
cord-332109-ont0tqpn	271	21	[	[	-LRB-
cord-332109-ont0tqpn	271	22	144	144	CD
cord-332109-ont0tqpn	271	23	]	]	-RRB-
cord-332109-ont0tqpn	271	24	[	[	-LRB-
cord-332109-ont0tqpn	271	25	145	145	CD
cord-332109-ont0tqpn	271	26	]	]	-RRB-
cord-332109-ont0tqpn	271	27	[	[	-LRB-
cord-332109-ont0tqpn	271	28	146	146	CD
cord-332109-ont0tqpn	271	29	]	]	-RRB-
cord-332109-ont0tqpn	271	30	.	.	.
cord-332109-ont0tqpn	272	1	The	the	DT
cord-332109-ont0tqpn	272	2	detrimental	detrimental	JJ
cord-332109-ont0tqpn	272	3	effects	effect	NNS
cord-332109-ont0tqpn	272	4	of	of	IN
cord-332109-ont0tqpn	272	5	cocaine	cocaine	NN
cord-332109-ont0tqpn	272	6	on	on	IN
cord-332109-ont0tqpn	272	7	the	the	DT
cord-332109-ont0tqpn	272	8	BBB	BBB	NNP
cord-332109-ont0tqpn	272	9	are	be	VBP
cord-332109-ont0tqpn	272	10	partially	partially	RB
cord-332109-ont0tqpn	272	11	attributed	attribute	VBN
cord-332109-ont0tqpn	272	12	to	to	IN
cord-332109-ont0tqpn	272	13	the	the	DT
cord-332109-ont0tqpn	272	14	loss	loss	NN
cord-332109-ont0tqpn	272	15	of	of	IN
cord-332109-ont0tqpn	272	16	tight	tight	JJ
cord-332109-ont0tqpn	272	17	junction	junction	NN
cord-332109-ont0tqpn	272	18	protein	protein	NN
cord-332109-ont0tqpn	272	19	complexes	complex	NNS
cord-332109-ont0tqpn	272	20	,	,	,
cord-332109-ont0tqpn	272	21	including	include	VBG
cord-332109-ont0tqpn	272	22	ZO-1	ZO-1	NNP
cord-332109-ont0tqpn	273	1	and	and	CC
cord-332109-ont0tqpn	273	2	JAM-2	JAM-2	NNP
cord-332109-ont0tqpn	273	3	[	[	-LRB-
cord-332109-ont0tqpn	273	4	146	146	CD
cord-332109-ont0tqpn	273	5	]	]	-RRB-
cord-332109-ont0tqpn	273	6	[	[	-LRB-
cord-332109-ont0tqpn	273	7	147	147	CD
cord-332109-ont0tqpn	273	8	]	]	-RRB-
cord-332109-ont0tqpn	273	9	[	[	-LRB-
cord-332109-ont0tqpn	273	10	148	148	CD
cord-332109-ont0tqpn	273	11	]	]	-RRB-
cord-332109-ont0tqpn	273	12	[	[	-LRB-
cord-332109-ont0tqpn	273	13	149	149	CD
cord-332109-ont0tqpn	273	14	]	]	-RRB-
cord-332109-ont0tqpn	273	15	.	.	.
cord-332109-ont0tqpn	274	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	274	2	also	also	RB
cord-332109-ont0tqpn	274	3	increases	increase	VBZ
cord-332109-ont0tqpn	274	4	the	the	DT
cord-332109-ont0tqpn	274	5	expression	expression	NN
cord-332109-ont0tqpn	274	6	of	of	IN
cord-332109-ont0tqpn	274	7	matrix	matrix	NN
cord-332109-ont0tqpn	274	8	metallopeptidase	metallopeptidase	NN
cord-332109-ont0tqpn	274	9	(	(	-LRB-
cord-332109-ont0tqpn	274	10	MMP)-1	MMP)-1	NNP
cord-332109-ont0tqpn	274	11	,	,	,
cord-332109-ont0tqpn	274	12	which	which	WDT
cord-332109-ont0tqpn	274	13	contributes	contribute	VBZ
cord-332109-ont0tqpn	274	14	to	to	IN
cord-332109-ont0tqpn	274	15	the	the	DT
cord-332109-ont0tqpn	274	16	rearrangement	rearrangement	NN
cord-332109-ont0tqpn	274	17	of	of	IN
cord-332109-ont0tqpn	274	18	the	the	DT
cord-332109-ont0tqpn	274	19	cytoskeleton	cytoskeleton	NN
cord-332109-ont0tqpn	274	20	structure	structure	NN
cord-332109-ont0tqpn	274	21	of	of	IN
cord-332109-ont0tqpn	274	22	the	the	DT
cord-332109-ont0tqpn	274	23	basement	basement	NN
cord-332109-ont0tqpn	274	24	membrane	membrane	NN
cord-332109-ont0tqpn	274	25	[	[	-LRB-
cord-332109-ont0tqpn	274	26	147	147	CD
cord-332109-ont0tqpn	274	27	,	,	,
cord-332109-ont0tqpn	274	28	148	148	CD
cord-332109-ont0tqpn	274	29	]	]	-RRB-
cord-332109-ont0tqpn	274	30	.	.	.
cord-332109-ont0tqpn	275	1	The	the	DT
cord-332109-ont0tqpn	275	2	adverse	adverse	JJ
cord-332109-ont0tqpn	275	3	effects	effect	NNS
cord-332109-ont0tqpn	275	4	of	of	IN
cord-332109-ont0tqpn	275	5	decreased	decrease	VBN
cord-332109-ont0tqpn	275	6	tight	tight	JJ
cord-332109-ont0tqpn	275	7	junction	junction	NN
cord-332109-ont0tqpn	275	8	protein	protein	NN
cord-332109-ont0tqpn	275	9	complexes	complex	NNS
cord-332109-ont0tqpn	275	10	and	and	CC
cord-332109-ont0tqpn	275	11	remodeling	remodeling	NN
cord-332109-ont0tqpn	275	12	of	of	IN
cord-332109-ont0tqpn	275	13	the	the	DT
cord-332109-ont0tqpn	275	14	basement	basement	NN
cord-332109-ont0tqpn	275	15	membrane	membrane	NN
cord-332109-ont0tqpn	275	16	fibers	fiber	NNS
cord-332109-ont0tqpn	275	17	cause	cause	VBP
cord-332109-ont0tqpn	275	18	the	the	DT
cord-332109-ont0tqpn	275	19	BBB	BBB	NNP
cord-332109-ont0tqpn	275	20	leakage	leakage	NN
cord-332109-ont0tqpn	275	21	and	and	CC
cord-332109-ont0tqpn	275	22	make	make	VB
cord-332109-ont0tqpn	275	23	it	-PRON-	PRP
cord-332109-ont0tqpn	275	24	open	open	JJ
cord-332109-ont0tqpn	275	25	to	to	IN
cord-332109-ont0tqpn	275	26	peripheral	peripheral	JJ
cord-332109-ont0tqpn	275	27	toxins	toxin	NNS
cord-332109-ont0tqpn	275	28	and	and	CC
cord-332109-ont0tqpn	275	29	viruses	virus	NNS
cord-332109-ont0tqpn	275	30	,	,	,
cord-332109-ont0tqpn	275	31	including	include	VBG
cord-332109-ont0tqpn	275	32	SARS	SARS	NNP
cord-332109-ont0tqpn	275	33	-	-	HYPH
cord-332109-ont0tqpn	275	34	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	275	35	.	.	.
cord-332109-ont0tqpn	276	1	An	an	DT
cord-332109-ont0tqpn	276	2	increase	increase	NN
cord-332109-ont0tqpn	276	3	in	in	IN
cord-332109-ont0tqpn	276	4	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	276	5	cytokine	cytokine	NN
cord-332109-ont0tqpn	276	6	,	,	,
cord-332109-ont0tqpn	276	7	TNFα	TNFα	NNP
cord-332109-ont0tqpn	276	8	,	,	,
cord-332109-ont0tqpn	276	9	has	have	VBZ
cord-332109-ont0tqpn	276	10	also	also	RB
cord-332109-ont0tqpn	276	11	been	be	VBN
cord-332109-ont0tqpn	276	12	reported	report	VBN
cord-332109-ont0tqpn	276	13	in	in	IN
cord-332109-ont0tqpn	276	14	BMVECs	bmvec	NNS
cord-332109-ont0tqpn	276	15	exposed	expose	VBN
cord-332109-ont0tqpn	276	16	to	to	IN
cord-332109-ont0tqpn	276	17	cocaine	cocaine	NN
cord-332109-ont0tqpn	276	18	[	[	-LRB-
cord-332109-ont0tqpn	276	19	150	150	CD
cord-332109-ont0tqpn	276	20	]	]	-RRB-
cord-332109-ont0tqpn	276	21	,	,	,
cord-332109-ont0tqpn	276	22	which	which	WDT
cord-332109-ont0tqpn	276	23	could	could	MD
cord-332109-ont0tqpn	276	24	be	be	VB
cord-332109-ont0tqpn	276	25	a	a	DT
cord-332109-ont0tqpn	276	26	concern	concern	NN
cord-332109-ont0tqpn	276	27	for	for	IN
cord-332109-ont0tqpn	276	28	endothelial	endothelial	JJ
cord-332109-ont0tqpn	276	29	health	health	NN
cord-332109-ont0tqpn	276	30	in	in	IN
cord-332109-ont0tqpn	276	31	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	276	32	.	.	.
cord-332109-ont0tqpn	277	1	d	d	LS
cord-332109-ont0tqpn	277	2	-	-	:
cord-332109-ont0tqpn	277	3	Amphetamine	Amphetamine	NNP
cord-332109-ont0tqpn	277	4	and	and	CC
cord-332109-ont0tqpn	277	5	its	-PRON-	PRP$
cord-332109-ont0tqpn	277	6	synthetic	synthetic	JJ
cord-332109-ont0tqpn	277	7	derivatives	derivative	NNS
cord-332109-ont0tqpn	277	8	,	,	,
cord-332109-ont0tqpn	277	9	METH	METH	NNS
cord-332109-ont0tqpn	277	10	and	and	CC
cord-332109-ont0tqpn	277	11	MDMA	MDMA	NNP
cord-332109-ont0tqpn	277	12	,	,	,
cord-332109-ont0tqpn	277	13	are	be	VBP
cord-332109-ont0tqpn	277	14	addictive	addictive	JJ
cord-332109-ont0tqpn	277	15	psychostimulants	psychostimulant	NNS
cord-332109-ont0tqpn	277	16	associated	associate	VBN
cord-332109-ont0tqpn	277	17	with	with	IN
cord-332109-ont0tqpn	277	18	neuropsychiatric	neuropsychiatric	JJ
cord-332109-ont0tqpn	277	19	complications	complication	NNS
cord-332109-ont0tqpn	277	20	,	,	,
cord-332109-ont0tqpn	277	21	including	include	VBG
cord-332109-ont0tqpn	277	22	deficits	deficit	NNS
cord-332109-ont0tqpn	277	23	in	in	IN
cord-332109-ont0tqpn	277	24	attention	attention	NN
cord-332109-ont0tqpn	277	25	,	,	,
cord-332109-ont0tqpn	277	26	memory	memory	NN
cord-332109-ont0tqpn	277	27	,	,	,
cord-332109-ont0tqpn	277	28	and	and	CC
cord-332109-ont0tqpn	277	29	executive	executive	JJ
cord-332109-ont0tqpn	277	30	functioning	function	VBG
cord-332109-ont0tqpn	277	31	[	[	-LRB-
cord-332109-ont0tqpn	277	32	151	151	CD
cord-332109-ont0tqpn	277	33	,	,	,
cord-332109-ont0tqpn	277	34	152	152	CD
cord-332109-ont0tqpn	277	35	]	]	-RRB-
cord-332109-ont0tqpn	277	36	.	.	.
cord-332109-ont0tqpn	278	1	Amphetamines	amphetamine	NNS
cord-332109-ont0tqpn	278	2	mediate	mediate	VBP
cord-332109-ont0tqpn	278	3	neurodegenerative	neurodegenerative	JJ
cord-332109-ont0tqpn	278	4	changes	change	NNS
cord-332109-ont0tqpn	278	5	in	in	IN
cord-332109-ont0tqpn	278	6	the	the	DT
cord-332109-ont0tqpn	278	7	brain	brain	NN
cord-332109-ont0tqpn	278	8	,	,	,
cord-332109-ont0tqpn	278	9	including	include	VBG
cord-332109-ont0tqpn	278	10	persistent	persistent	JJ
cord-332109-ont0tqpn	278	11	loss	loss	NN
cord-332109-ont0tqpn	278	12	of	of	IN
cord-332109-ont0tqpn	278	13	dopamine	dopamine	NN
cord-332109-ont0tqpn	278	14	(	(	-LRB-
cord-332109-ont0tqpn	278	15	DA	DA	NNP
cord-332109-ont0tqpn	278	16	)	)	-RRB-
cord-332109-ont0tqpn	278	17	transporters	transporter	NNS
cord-332109-ont0tqpn	278	18	[	[	-LRB-
cord-332109-ont0tqpn	278	19	153	153	CD
cord-332109-ont0tqpn	278	20	]	]	-RRB-
cord-332109-ont0tqpn	278	21	[	[	-LRB-
cord-332109-ont0tqpn	278	22	154	154	CD
cord-332109-ont0tqpn	278	23	]	]	-RRB-
cord-332109-ont0tqpn	278	24	[	[	-LRB-
cord-332109-ont0tqpn	278	25	155	155	CD
cord-332109-ont0tqpn	278	26	]	]	-RRB-
cord-332109-ont0tqpn	278	27	[	[	-LRB-
cord-332109-ont0tqpn	278	28	156	156	CD
cord-332109-ont0tqpn	278	29	]	]	-RRB-
cord-332109-ont0tqpn	278	30	[	[	-LRB-
cord-332109-ont0tqpn	278	31	157	157	CD
cord-332109-ont0tqpn	278	32	]	]	-RRB-
cord-332109-ont0tqpn	278	33	and	and	CC
cord-332109-ont0tqpn	278	34	receptors	receptor	NNS
cord-332109-ont0tqpn	278	35	[	[	-LRB-
cord-332109-ont0tqpn	278	36	158	158	CD
cord-332109-ont0tqpn	278	37	]	]	-RRB-
cord-332109-ont0tqpn	278	38	,	,	,
cord-332109-ont0tqpn	278	39	loss	loss	NN
cord-332109-ont0tqpn	278	40	of	of	IN
cord-332109-ont0tqpn	278	41	serotonin	serotonin	NN
cord-332109-ont0tqpn	278	42	(	(	-LRB-
cord-332109-ont0tqpn	278	43	5-HT	5-ht	CD
cord-332109-ont0tqpn	278	44	)	)	-RRB-
cord-332109-ont0tqpn	278	45	transporters	transporter	NNS
cord-332109-ont0tqpn	278	46	[	[	-LRB-
cord-332109-ont0tqpn	278	47	159	159	CD
cord-332109-ont0tqpn	278	48	]	]	-RRB-
cord-332109-ont0tqpn	278	49	,	,	,
cord-332109-ont0tqpn	278	50	and	and	CC
cord-332109-ont0tqpn	278	51	decrease	decrease	VB
cord-332109-ont0tqpn	278	52	in	in	IN
cord-332109-ont0tqpn	278	53	dopamine	dopamine	NN
cord-332109-ont0tqpn	278	54	and	and	CC
cord-332109-ont0tqpn	278	55	serotonin	serotonin	NN
cord-332109-ont0tqpn	278	56	level	level	NN
cord-332109-ont0tqpn	278	57	and	and	CC
cord-332109-ont0tqpn	278	58	its	-PRON-	PRP$
cord-332109-ont0tqpn	278	59	metabolites	metabolite	NNS
cord-332109-ont0tqpn	278	60	[	[	-LRB-
cord-332109-ont0tqpn	278	61	160	160	CD
cord-332109-ont0tqpn	278	62	]	]	-RRB-
cord-332109-ont0tqpn	278	63	[	[	-LRB-
cord-332109-ont0tqpn	278	64	161	161	CD
cord-332109-ont0tqpn	278	65	]	]	-RRB-
cord-332109-ont0tqpn	278	66	[	[	-LRB-
cord-332109-ont0tqpn	278	67	162	162	CD
cord-332109-ont0tqpn	278	68	]	]	-RRB-
cord-332109-ont0tqpn	278	69	.	.	.
cord-332109-ont0tqpn	279	1	METH	METH	NNP
cord-332109-ont0tqpn	279	2	has	have	VBZ
cord-332109-ont0tqpn	279	3	been	be	VBN
cord-332109-ont0tqpn	279	4	linked	link	VBN
cord-332109-ont0tqpn	279	5	to	to	IN
cord-332109-ont0tqpn	279	6	various	various	JJ
cord-332109-ont0tqpn	279	7	cardiac	cardiac	JJ
cord-332109-ont0tqpn	279	8	pathologies	pathology	NNS
cord-332109-ont0tqpn	279	9	,	,	,
cord-332109-ont0tqpn	279	10	including	include	VBG
cord-332109-ont0tqpn	279	11	hypertension	hypertension	NN
cord-332109-ont0tqpn	279	12	,	,	,
cord-332109-ont0tqpn	279	13	tachycardia	tachycardia	NN
cord-332109-ont0tqpn	279	14	,	,	,
cord-332109-ont0tqpn	279	15	and	and	CC
cord-332109-ont0tqpn	279	16	congestive	congestive	JJ
cord-332109-ont0tqpn	279	17	heart	heart	NN
cord-332109-ont0tqpn	279	18	failure	failure	NN
cord-332109-ont0tqpn	279	19	or	or	CC
cord-332109-ont0tqpn	279	20	cardiomyopathy	cardiomyopathy	NN
cord-332109-ont0tqpn	279	21	[	[	-LRB-
cord-332109-ont0tqpn	279	22	16	16	CD
cord-332109-ont0tqpn	279	23	]	]	-RRB-
cord-332109-ont0tqpn	279	24	.	.	.
cord-332109-ont0tqpn	280	1	Clinically	clinically	RB
cord-332109-ont0tqpn	280	2	,	,	,
cord-332109-ont0tqpn	280	3	METH	METH	NNS
cord-332109-ont0tqpn	280	4	abusers	abuser	NNS
cord-332109-ont0tqpn	280	5	commonly	commonly	RB
cord-332109-ont0tqpn	280	6	showed	show	VBD
cord-332109-ont0tqpn	280	7	dilated	dilated	JJ
cord-332109-ont0tqpn	280	8	and	and	CC
cord-332109-ont0tqpn	280	9	poorly	poorly	RB
cord-332109-ont0tqpn	280	10	contracting	contracting	NN
cord-332109-ont0tqpn	280	11	left	leave	VBN
cord-332109-ont0tqpn	280	12	ventricles	ventricle	NNS
cord-332109-ont0tqpn	280	13	(	(	-LRB-
cord-332109-ont0tqpn	280	14	LV	LV	NNP
cord-332109-ont0tqpn	280	15	)	)	-RRB-
cord-332109-ont0tqpn	280	16	and	and	CC
cord-332109-ont0tqpn	280	17	substantially	substantially	RB
cord-332109-ont0tqpn	280	18	lowered	lower	VBN
cord-332109-ont0tqpn	280	19	left	leave	VBN
cord-332109-ont0tqpn	280	20	ventricular	ventricular	JJ
cord-332109-ont0tqpn	280	21	ejection	ejection	NN
cord-332109-ont0tqpn	280	22	fractions	fraction	NNS
cord-332109-ont0tqpn	280	23	(	(	-LRB-
cord-332109-ont0tqpn	280	24	LVEF	LVEF	NNP
cord-332109-ont0tqpn	280	25	)	)	-RRB-
cord-332109-ont0tqpn	280	26	in	in	IN
cord-332109-ont0tqpn	280	27	comparison	comparison	NN
cord-332109-ont0tqpn	280	28	to	to	IN
cord-332109-ont0tqpn	280	29	non	non	NNS
cord-332109-ont0tqpn	280	30	-	-	NNS
cord-332109-ont0tqpn	280	31	users	user	NNS
cord-332109-ont0tqpn	280	32	[	[	-LRB-
cord-332109-ont0tqpn	280	33	163	163	CD
cord-332109-ont0tqpn	280	34	]	]	-RRB-
cord-332109-ont0tqpn	280	35	.	.	.
cord-332109-ont0tqpn	281	1	METH	METH	NNS
cord-332109-ont0tqpn	281	2	-	-	HYPH
cord-332109-ont0tqpn	281	3	associated	associate	VBN
cord-332109-ont0tqpn	281	4	cardiac	cardiac	JJ
cord-332109-ont0tqpn	281	5	pathologies	pathology	NNS
cord-332109-ont0tqpn	281	6	are	be	VBP
cord-332109-ont0tqpn	281	7	a	a	DT
cord-332109-ont0tqpn	281	8	major	major	JJ
cord-332109-ont0tqpn	281	9	cause	cause	NN
cord-332109-ont0tqpn	281	10	of	of	IN
cord-332109-ont0tqpn	281	11	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	281	12	edema	edema	NN
cord-332109-ont0tqpn	281	13	.	.	.
cord-332109-ont0tqpn	282	1	The	the	DT
cord-332109-ont0tqpn	282	2	reduced	reduce	VBN
cord-332109-ont0tqpn	282	3	lung	lung	NN
cord-332109-ont0tqpn	282	4	capacity	capacity	NN
cord-332109-ont0tqpn	282	5	due	due	IN
cord-332109-ont0tqpn	282	6	to	to	IN
cord-332109-ont0tqpn	282	7	the	the	DT
cord-332109-ont0tqpn	282	8	fluid	fluid	JJ
cord-332109-ont0tqpn	282	9	collection	collection	NN
cord-332109-ont0tqpn	282	10	in	in	IN
cord-332109-ont0tqpn	282	11	the	the	DT
cord-332109-ont0tqpn	282	12	lungs	lung	NNS
cord-332109-ont0tqpn	282	13	and	and	CC
cord-332109-ont0tqpn	282	14	constriction	constriction	NN
cord-332109-ont0tqpn	282	15	of	of	IN
cord-332109-ont0tqpn	282	16	blood	blood	NN
cord-332109-ont0tqpn	282	17	vessels	vessel	NNS
cord-332109-ont0tqpn	282	18	can	can	MD
cord-332109-ont0tqpn	282	19	severely	severely	RB
cord-332109-ont0tqpn	282	20	complicate	complicate	VB
cord-332109-ont0tqpn	282	21	COVID-19	covid-19	CD
cord-332109-ont0tqpn	282	22	symptoms	symptom	NNS
cord-332109-ont0tqpn	282	23	and	and	CC
cord-332109-ont0tqpn	282	24	negative	negative	JJ
cord-332109-ont0tqpn	282	25	prognosis	prognosis	NN
cord-332109-ont0tqpn	282	26	.	.	.
cord-332109-ont0tqpn	283	1	Amphetamines	amphetamine	NNS
cord-332109-ont0tqpn	283	2	stimulate	stimulate	VBP
cord-332109-ont0tqpn	283	3	the	the	DT
cord-332109-ont0tqpn	283	4	HPA	HPA	NNP
cord-332109-ont0tqpn	283	5	axis	axis	NN
cord-332109-ont0tqpn	283	6	and	and	CC
cord-332109-ont0tqpn	283	7	increase	increase	VB
cord-332109-ont0tqpn	283	8	the	the	DT
cord-332109-ont0tqpn	283	9	plasma	plasma	NN
cord-332109-ont0tqpn	283	10	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	283	11	through	through	IN
cord-332109-ont0tqpn	283	12	a	a	DT
cord-332109-ont0tqpn	283	13	CRH	crh	NN
cord-332109-ont0tqpn	283	14	-	-	HYPH
cord-332109-ont0tqpn	283	15	dependent	dependent	JJ
cord-332109-ont0tqpn	283	16	mechanism	mechanism	NN
cord-332109-ont0tqpn	283	17	involving	involve	VBG
cord-332109-ont0tqpn	283	18	serotonin	serotonin	NN
cord-332109-ont0tqpn	283	19	[	[	-LRB-
cord-332109-ont0tqpn	283	20	164	164	CD
cord-332109-ont0tqpn	283	21	]	]	-RRB-
cord-332109-ont0tqpn	284	1	[	[	-LRB-
cord-332109-ont0tqpn	284	2	165	165	CD
cord-332109-ont0tqpn	284	3	]	]	-RRB-
cord-332109-ont0tqpn	284	4	[	[	-LRB-
cord-332109-ont0tqpn	284	5	166	166	CD
cord-332109-ont0tqpn	284	6	]	]	-RRB-
cord-332109-ont0tqpn	284	7	[	[	-LRB-
cord-332109-ont0tqpn	284	8	167	167	CD
cord-332109-ont0tqpn	284	9	]	]	-RRB-
cord-332109-ont0tqpn	284	10	.	.	.
cord-332109-ont0tqpn	285	1	The	the	DT
cord-332109-ont0tqpn	285	2	stimulation	stimulation	NN
cord-332109-ont0tqpn	285	3	increases	increase	VBZ
cord-332109-ont0tqpn	285	4	the	the	DT
cord-332109-ont0tqpn	285	5	production	production	NN
cord-332109-ont0tqpn	285	6	of	of	IN
cord-332109-ont0tqpn	285	7	CRH	CRH	NNP
cord-332109-ont0tqpn	285	8	and	and	CC
cord-332109-ont0tqpn	285	9	AVP	AVP	NNP
cord-332109-ont0tqpn	285	10	in	in	IN
cord-332109-ont0tqpn	285	11	the	the	DT
cord-332109-ont0tqpn	285	12	PVN	PVN	NNP
cord-332109-ont0tqpn	285	13	neurons	neuron	NNS
cord-332109-ont0tqpn	285	14	,	,	,
cord-332109-ont0tqpn	285	15	which	which	WDT
cord-332109-ont0tqpn	285	16	,	,	,
cord-332109-ont0tqpn	285	17	in	in	IN
cord-332109-ont0tqpn	285	18	turn	turn	NN
cord-332109-ont0tqpn	285	19	,	,	,
cord-332109-ont0tqpn	285	20	activates	activate	VBZ
cord-332109-ont0tqpn	285	21	the	the	DT
cord-332109-ont0tqpn	285	22	production	production	NN
cord-332109-ont0tqpn	285	23	of	of	IN
cord-332109-ont0tqpn	285	24	ACTH	ACTH	NNP
cord-332109-ont0tqpn	285	25	in	in	IN
cord-332109-ont0tqpn	285	26	corticotropic	corticotropic	NNP
cord-332109-ont0tqpn	285	27	cells	cell	NNS
cord-332109-ont0tqpn	285	28	in	in	IN
cord-332109-ont0tqpn	285	29	the	the	DT
cord-332109-ont0tqpn	285	30	anterior	anterior	JJ
cord-332109-ont0tqpn	285	31	pituitary	pituitary	JJ
cord-332109-ont0tqpn	285	32	gland	gland	NN
cord-332109-ont0tqpn	285	33	.	.	.
cord-332109-ont0tqpn	286	1	ACTH	ACTH	NNP
cord-332109-ont0tqpn	286	2	circulates	circulate	VBZ
cord-332109-ont0tqpn	286	3	through	through	IN
cord-332109-ont0tqpn	286	4	the	the	DT
cord-332109-ont0tqpn	286	5	systemic	systemic	JJ
cord-332109-ont0tqpn	286	6	blood	blood	NN
cord-332109-ont0tqpn	286	7	stream	stream	NN
cord-332109-ont0tqpn	286	8	to	to	TO
cord-332109-ont0tqpn	286	9	reach	reach	VB
cord-332109-ont0tqpn	286	10	and	and	CC
cord-332109-ont0tqpn	286	11	activate	activate	VB
cord-332109-ont0tqpn	286	12	the	the	DT
cord-332109-ont0tqpn	286	13	adrenal	adrenal	JJ
cord-332109-ont0tqpn	286	14	cortex	cortex	NN
cord-332109-ont0tqpn	286	15	to	to	TO
cord-332109-ont0tqpn	286	16	release	release	VB
cord-332109-ont0tqpn	286	17	glucocorticoids	glucocorticoid	NNS
cord-332109-ont0tqpn	286	18	.	.	.
cord-332109-ont0tqpn	287	1	The	the	DT
cord-332109-ont0tqpn	287	2	HPA	HPA	NNP
cord-332109-ont0tqpn	287	3	axis	axis	NN
cord-332109-ont0tqpn	287	4	is	be	VBZ
cord-332109-ont0tqpn	287	5	an	an	DT
cord-332109-ont0tqpn	287	6	essential	essential	JJ
cord-332109-ont0tqpn	287	7	component	component	NN
cord-332109-ont0tqpn	287	8	of	of	IN
cord-332109-ont0tqpn	287	9	the	the	DT
cord-332109-ont0tqpn	287	10	response	response	NN
cord-332109-ont0tqpn	287	11	to	to	IN
cord-332109-ont0tqpn	287	12	pathogen	pathogen	NN
cord-332109-ont0tqpn	287	13	infections	infection	NNS
cord-332109-ont0tqpn	287	14	.	.	.
cord-332109-ont0tqpn	288	1	However	however	RB
cord-332109-ont0tqpn	288	2	,	,	,
cord-332109-ont0tqpn	288	3	chronic	chronic	JJ
cord-332109-ont0tqpn	288	4	activation	activation	NN
cord-332109-ont0tqpn	288	5	of	of	IN
cord-332109-ont0tqpn	288	6	the	the	DT
cord-332109-ont0tqpn	288	7	HPA	HPA	NNP
cord-332109-ont0tqpn	288	8	axis	axis	NN
cord-332109-ont0tqpn	288	9	and	and	CC
cord-332109-ont0tqpn	288	10	markedly	markedly	RB
cord-332109-ont0tqpn	288	11	increased	increase	VBN
cord-332109-ont0tqpn	288	12	glucocorticoid	glucocorticoid	NN
cord-332109-ont0tqpn	288	13	due	due	IN
cord-332109-ont0tqpn	288	14	to	to	IN
cord-332109-ont0tqpn	288	15	the	the	DT
cord-332109-ont0tqpn	288	16	recreational	recreational	JJ
cord-332109-ont0tqpn	288	17	use	use	NN
cord-332109-ont0tqpn	288	18	of	of	IN
cord-332109-ont0tqpn	288	19	amphetamine	amphetamine	NN
cord-332109-ont0tqpn	288	20	,	,	,
cord-332109-ont0tqpn	288	21	METH	METH	NNP
cord-332109-ont0tqpn	288	22	,	,	,
cord-332109-ont0tqpn	288	23	and	and	CC
cord-332109-ont0tqpn	288	24	MDMA	MDMA	NNP
cord-332109-ont0tqpn	288	25	can	can	MD
cord-332109-ont0tqpn	288	26	be	be	VB
cord-332109-ont0tqpn	288	27	harmful	harmful	JJ
cord-332109-ont0tqpn	288	28	to	to	IN
cord-332109-ont0tqpn	288	29	the	the	DT
cord-332109-ont0tqpn	288	30	brain	brain	NN
cord-332109-ont0tqpn	288	31	.	.	.
cord-332109-ont0tqpn	289	1	Amphetamines	amphetamine	NNS
cord-332109-ont0tqpn	289	2	modify	modify	VBP
cord-332109-ont0tqpn	289	3	brain	brain	NN
cord-332109-ont0tqpn	289	4	expression	expression	NN
cord-332109-ont0tqpn	289	5	of	of	IN
cord-332109-ont0tqpn	289	6	the	the	DT
cord-332109-ont0tqpn	289	7	genes	gene	NNS
cord-332109-ont0tqpn	289	8	and	and	CC
cord-332109-ont0tqpn	289	9	proteins	protein	NNS
cord-332109-ont0tqpn	289	10	associated	associate	VBN
cord-332109-ont0tqpn	289	11	with	with	IN
cord-332109-ont0tqpn	289	12	the	the	DT
cord-332109-ont0tqpn	289	13	HPA	HPA	NNP
cord-332109-ont0tqpn	289	14	axis	axis	NN
cord-332109-ont0tqpn	289	15	,	,	,
cord-332109-ont0tqpn	289	16	including	include	VBG
cord-332109-ont0tqpn	289	17	the	the	DT
cord-332109-ont0tqpn	289	18	glucocorticoid	glucocorticoid	NN
cord-332109-ont0tqpn	289	19	receptor	receptor	NN
cord-332109-ont0tqpn	289	20	(	(	-LRB-
cord-332109-ont0tqpn	289	21	GR	GR	NNP
cord-332109-ont0tqpn	289	22	)	)	-RRB-
cord-332109-ont0tqpn	289	23	and	and	CC
cord-332109-ont0tqpn	289	24	the	the	DT
cord-332109-ont0tqpn	289	25	mineralocorticoid	mineralocorticoid	NN
cord-332109-ont0tqpn	289	26	receptor	receptor	NN
cord-332109-ont0tqpn	289	27	(	(	-LRB-
cord-332109-ont0tqpn	289	28	MR	MR	NNP
cord-332109-ont0tqpn	289	29	)	)	-RRB-
cord-332109-ont0tqpn	289	30	.	.	.
cord-332109-ont0tqpn	290	1	The	the	DT
cord-332109-ont0tqpn	290	2	remodeling	remodeling	NN
cord-332109-ont0tqpn	290	3	of	of	IN
cord-332109-ont0tqpn	290	4	brain	brain	NN
cord-332109-ont0tqpn	290	5	cells	cell	NNS
cord-332109-ont0tqpn	290	6	and	and	CC
cord-332109-ont0tqpn	290	7	disruption	disruption	NN
cord-332109-ont0tqpn	290	8	of	of	IN
cord-332109-ont0tqpn	290	9	the	the	DT
cord-332109-ont0tqpn	290	10	HPA	HPA	NNP
cord-332109-ont0tqpn	290	11	axis	axis	NN
cord-332109-ont0tqpn	290	12	are	be	VBP
cord-332109-ont0tqpn	290	13	the	the	DT
cord-332109-ont0tqpn	290	14	hallmarks	hallmark	NNS
cord-332109-ont0tqpn	290	15	of	of	IN
cord-332109-ont0tqpn	290	16	depression	depression	NN
cord-332109-ont0tqpn	290	17	and	and	CC
cord-332109-ont0tqpn	290	18	anxiety	anxiety	NN
cord-332109-ont0tqpn	290	19	/	/	SYM
cord-332109-ont0tqpn	290	20	despair	despair	NN
cord-332109-ont0tqpn	290	21	states	state	NNS
cord-332109-ont0tqpn	290	22	associated	associate	VBN
cord-332109-ont0tqpn	290	23	with	with	IN
cord-332109-ont0tqpn	290	24	drug	drug	NN
cord-332109-ont0tqpn	290	25	use	use	NN
cord-332109-ont0tqpn	290	26	[	[	-LRB-
cord-332109-ont0tqpn	290	27	168	168	CD
cord-332109-ont0tqpn	290	28	,	,	,
cord-332109-ont0tqpn	290	29	169	169	CD
cord-332109-ont0tqpn	290	30	]	]	-RRB-
cord-332109-ont0tqpn	290	31	.	.	.
cord-332109-ont0tqpn	291	1	As	as	IN
cord-332109-ont0tqpn	291	2	mentioned	mention	VBN
cord-332109-ont0tqpn	291	3	earlier	early	RBR
cord-332109-ont0tqpn	291	4	,	,	,
cord-332109-ont0tqpn	291	5	the	the	DT
cord-332109-ont0tqpn	291	6	disruption	disruption	NN
cord-332109-ont0tqpn	291	7	of	of	IN
cord-332109-ont0tqpn	291	8	the	the	DT
cord-332109-ont0tqpn	291	9	HPA	HPA	NNP
cord-332109-ont0tqpn	291	10	axis	axis	NN
cord-332109-ont0tqpn	291	11	and	and	CC
cord-332109-ont0tqpn	291	12	the	the	DT
cord-332109-ont0tqpn	291	13	associated	associate	VBN
cord-332109-ont0tqpn	291	14	immune	immune	JJ
cord-332109-ont0tqpn	291	15	suppression	suppression	NN
cord-332109-ont0tqpn	291	16	could	could	MD
cord-332109-ont0tqpn	291	17	pose	pose	VB
cord-332109-ont0tqpn	291	18	the	the	DT
cord-332109-ont0tqpn	291	19	drug	drug	NN
cord-332109-ont0tqpn	291	20	abusers	abuser	NNS
cord-332109-ont0tqpn	291	21	to	to	IN
cord-332109-ont0tqpn	291	22	a	a	DT
cord-332109-ont0tqpn	291	23	higher	high	JJR
cord-332109-ont0tqpn	291	24	risk	risk	NN
cord-332109-ont0tqpn	291	25	of	of	IN
cord-332109-ont0tqpn	291	26	viral	viral	JJ
cord-332109-ont0tqpn	291	27	infections	infection	NNS
cord-332109-ont0tqpn	291	28	.	.	.
cord-332109-ont0tqpn	292	1	SARS	SARS	NNP
cord-332109-ont0tqpn	292	2	-	-	HYPH
cord-332109-ont0tqpn	292	3	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	292	4	,	,	,
cord-332109-ont0tqpn	292	5	known	know	VBN
cord-332109-ont0tqpn	292	6	for	for	IN
cord-332109-ont0tqpn	292	7	its	-PRON-	PRP$
cord-332109-ont0tqpn	292	8	high	high	JJ
cord-332109-ont0tqpn	292	9	infection	infection	NN
cord-332109-ont0tqpn	292	10	rate	rate	NN
cord-332109-ont0tqpn	292	11	,	,	,
cord-332109-ont0tqpn	292	12	will	will	MD
cord-332109-ont0tqpn	292	13	be	be	VB
cord-332109-ont0tqpn	292	14	particularly	particularly	RB
cord-332109-ont0tqpn	292	15	harmful	harmful	JJ
cord-332109-ont0tqpn	292	16	to	to	IN
cord-332109-ont0tqpn	292	17	individuals	individual	NNS
cord-332109-ont0tqpn	292	18	with	with	IN
cord-332109-ont0tqpn	292	19	defective	defective	JJ
cord-332109-ont0tqpn	292	20	immune	immune	JJ
cord-332109-ont0tqpn	292	21	systems	system	NNS
cord-332109-ont0tqpn	292	22	related	relate	VBN
cord-332109-ont0tqpn	292	23	to	to	IN
cord-332109-ont0tqpn	292	24	the	the	DT
cord-332109-ont0tqpn	292	25	use	use	NN
cord-332109-ont0tqpn	292	26	of	of	IN
cord-332109-ont0tqpn	292	27	addictive	addictive	JJ
cord-332109-ont0tqpn	292	28	drugs	drug	NNS
cord-332109-ont0tqpn	292	29	.	.	.
cord-332109-ont0tqpn	293	1	Amphetamine	amphetamine	NN
cord-332109-ont0tqpn	293	2	-	-	HYPH
cord-332109-ont0tqpn	293	3	like	like	JJ
cord-332109-ont0tqpn	293	4	psychostimulants	psychostimulant	NNS
cord-332109-ont0tqpn	293	5	can	can	MD
cord-332109-ont0tqpn	293	6	trigger	trigger	VB
cord-332109-ont0tqpn	293	7	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	293	8	processes	process	NNS
cord-332109-ont0tqpn	293	9	,	,	,
cord-332109-ont0tqpn	293	10	compromise	compromise	NN
cord-332109-ont0tqpn	293	11	neurogenesis	neurogenesis	NN
cord-332109-ont0tqpn	293	12	in	in	IN
cord-332109-ont0tqpn	293	13	the	the	DT
cord-332109-ont0tqpn	293	14	brain	brain	NN
cord-332109-ont0tqpn	293	15	,	,	,
cord-332109-ont0tqpn	293	16	and	and	CC
cord-332109-ont0tqpn	293	17	damage	damage	VB
cord-332109-ont0tqpn	293	18	the	the	DT
cord-332109-ont0tqpn	293	19	BBB	BBB	NNP
cord-332109-ont0tqpn	293	20	integrity	integrity	NN
cord-332109-ont0tqpn	293	21	[	[	-LRB-
cord-332109-ont0tqpn	293	22	170	170	CD
cord-332109-ont0tqpn	293	23	]	]	-RRB-
cord-332109-ont0tqpn	293	24	.	.	.
cord-332109-ont0tqpn	294	1	METH	METH	NNS
cord-332109-ont0tqpn	294	2	,	,	,
cord-332109-ont0tqpn	294	3	for	for	IN
cord-332109-ont0tqpn	294	4	example	example	NN
cord-332109-ont0tqpn	294	5	,	,	,
cord-332109-ont0tqpn	294	6	is	be	VBZ
cord-332109-ont0tqpn	294	7	strongly	strongly	RB
cord-332109-ont0tqpn	294	8	associated	associate	VBN
cord-332109-ont0tqpn	294	9	with	with	IN
cord-332109-ont0tqpn	294	10	ischemic	ischemic	JJ
cord-332109-ont0tqpn	294	11	stroke	stroke	NN
cord-332109-ont0tqpn	294	12	and	and	CC
cord-332109-ont0tqpn	294	13	hypoxia	hypoxia	NN
cord-332109-ont0tqpn	294	14	[	[	-LRB-
cord-332109-ont0tqpn	294	15	171	171	CD
cord-332109-ont0tqpn	294	16	,	,	,
cord-332109-ont0tqpn	294	17	172	172	CD
cord-332109-ont0tqpn	294	18	]	]	-RRB-
cord-332109-ont0tqpn	294	19	.	.	.
cord-332109-ont0tqpn	295	1	Binge	binge	NN
cord-332109-ont0tqpn	295	2	use	use	NN
cord-332109-ont0tqpn	295	3	of	of	IN
cord-332109-ont0tqpn	295	4	METH	METH	NNP
cord-332109-ont0tqpn	295	5	causes	cause	VBZ
cord-332109-ont0tqpn	295	6	a	a	DT
cord-332109-ont0tqpn	295	7	sustained	sustained	JJ
cord-332109-ont0tqpn	295	8	reduction	reduction	NN
cord-332109-ont0tqpn	295	9	in	in	IN
cord-332109-ont0tqpn	295	10	global	global	JJ
cord-332109-ont0tqpn	295	11	and	and	CC
cord-332109-ont0tqpn	295	12	cerebral	cerebral	JJ
cord-332109-ont0tqpn	295	13	blood	blood	NN
cord-332109-ont0tqpn	295	14	flow	flow	NN
cord-332109-ont0tqpn	295	15	[	[	-LRB-
cord-332109-ont0tqpn	295	16	173	173	CD
cord-332109-ont0tqpn	295	17	,	,	,
cord-332109-ont0tqpn	295	18	174	174	CD
cord-332109-ont0tqpn	295	19	]	]	-RRB-
cord-332109-ont0tqpn	295	20	.	.	.
cord-332109-ont0tqpn	296	1	METH	METH	NNP
cord-332109-ont0tqpn	296	2	is	be	VBZ
cord-332109-ont0tqpn	296	3	also	also	RB
cord-332109-ont0tqpn	296	4	known	know	VBN
cord-332109-ont0tqpn	296	5	to	to	TO
cord-332109-ont0tqpn	296	6	damage	damage	VB
cord-332109-ont0tqpn	296	7	the	the	DT
cord-332109-ont0tqpn	296	8	central	central	JJ
cord-332109-ont0tqpn	296	9	nervous	nervous	JJ
cord-332109-ont0tqpn	296	10	system	system	NN
cord-332109-ont0tqpn	296	11	(	(	-LRB-
cord-332109-ont0tqpn	296	12	CNS	CNS	NNP
cord-332109-ont0tqpn	296	13	)	)	-RRB-
cord-332109-ont0tqpn	296	14	by	by	IN
cord-332109-ont0tqpn	296	15	compromising	compromise	VBG
cord-332109-ont0tqpn	296	16	the	the	DT
cord-332109-ont0tqpn	296	17	integrity	integrity	NN
cord-332109-ont0tqpn	296	18	of	of	IN
cord-332109-ont0tqpn	296	19	the	the	DT
cord-332109-ont0tqpn	296	20	blood	blood	NN
cord-332109-ont0tqpn	296	21	-	-	HYPH
cord-332109-ont0tqpn	296	22	brain	brain	NN
cord-332109-ont0tqpn	296	23	barrier	barrier	NN
cord-332109-ont0tqpn	296	24	(	(	-LRB-
cord-332109-ont0tqpn	296	25	BBB	BBB	NNP
cord-332109-ont0tqpn	296	26	)	)	-RRB-
cord-332109-ont0tqpn	297	1	[	[	-LRB-
cord-332109-ont0tqpn	297	2	175	175	CD
cord-332109-ont0tqpn	297	3	]	]	-RRB-
cord-332109-ont0tqpn	298	1	[	[	-LRB-
cord-332109-ont0tqpn	298	2	176	176	CD
cord-332109-ont0tqpn	298	3	]	]	-RRB-
cord-332109-ont0tqpn	298	4	[	[	-LRB-
cord-332109-ont0tqpn	298	5	177	177	CD
cord-332109-ont0tqpn	298	6	]	]	-RRB-
cord-332109-ont0tqpn	298	7	.	.	.
cord-332109-ont0tqpn	299	1	METH	METH	NNP
cord-332109-ont0tqpn	299	2	and	and	CC
cord-332109-ont0tqpn	299	3	MDMA	MDMA	NNP
cord-332109-ont0tqpn	299	4	can	can	MD
cord-332109-ont0tqpn	299	5	decrease	decrease	VB
cord-332109-ont0tqpn	299	6	the	the	DT
cord-332109-ont0tqpn	299	7	expression	expression	NN
cord-332109-ont0tqpn	299	8	of	of	IN
cord-332109-ont0tqpn	299	9	tight	tight	JJ
cord-332109-ont0tqpn	299	10	junction	junction	NN
cord-332109-ont0tqpn	299	11	proteins	protein	NNS
cord-332109-ont0tqpn	299	12	,	,	,
cord-332109-ont0tqpn	299	13	including	include	VBG
cord-332109-ont0tqpn	299	14	ZO-1	ZO-1	NNP
cord-332109-ont0tqpn	299	15	,	,	,
cord-332109-ont0tqpn	299	16	occludin	occludin	NNP
cord-332109-ont0tqpn	299	17	,	,	,
cord-332109-ont0tqpn	299	18	and	and	CC
cord-332109-ont0tqpn	299	19	claudin-5	claudin-5	NNP
cord-332109-ont0tqpn	299	20	.	.	.
cord-332109-ont0tqpn	300	1	These	these	DT
cord-332109-ont0tqpn	300	2	drugs	drug	NNS
cord-332109-ont0tqpn	300	3	activate	activate	VBP
cord-332109-ont0tqpn	300	4	microglia	microglia	NNS
cord-332109-ont0tqpn	300	5	and	and	CC
cord-332109-ont0tqpn	300	6	astrocyte	astrocyte	NN
cord-332109-ont0tqpn	300	7	to	to	TO
cord-332109-ont0tqpn	300	8	secrete	secrete	VB
cord-332109-ont0tqpn	300	9	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	300	10	cytokines	cytokine	NNS
cord-332109-ont0tqpn	300	11	and	and	CC
cord-332109-ont0tqpn	300	12	chemokines	chemokine	NNS
cord-332109-ont0tqpn	300	13	,	,	,
cord-332109-ont0tqpn	300	14	as	as	RB
cord-332109-ont0tqpn	300	15	well	well	RB
cord-332109-ont0tqpn	300	16	as	as	IN
cord-332109-ont0tqpn	300	17	vasoactive	vasoactive	JJ
cord-332109-ont0tqpn	300	18	factors	factor	NNS
cord-332109-ont0tqpn	300	19	,	,	,
cord-332109-ont0tqpn	300	20	and	and	CC
cord-332109-ont0tqpn	300	21	elevate	elevate	VB
cord-332109-ont0tqpn	300	22	expression	expression	NN
cord-332109-ont0tqpn	300	23	of	of	IN
cord-332109-ont0tqpn	300	24	peptidases	peptidase	NNS
cord-332109-ont0tqpn	300	25	,	,	,
cord-332109-ont0tqpn	300	26	such	such	JJ
cord-332109-ont0tqpn	300	27	as	as	IN
cord-332109-ont0tqpn	300	28	MMP-1	MMP-1	NNP
cord-332109-ont0tqpn	300	29	and	and	CC
cord-332109-ont0tqpn	300	30	MMP-9	MMP-9	NNP
cord-332109-ont0tqpn	300	31	,	,	,
cord-332109-ont0tqpn	300	32	to	to	TO
cord-332109-ont0tqpn	300	33	degrade	degrade	VB
cord-332109-ont0tqpn	300	34	tight	tight	JJ
cord-332109-ont0tqpn	300	35	junction	junction	NN
cord-332109-ont0tqpn	300	36	proteins	protein	NNS
cord-332109-ont0tqpn	300	37	and	and	CC
cord-332109-ont0tqpn	300	38	modify	modify	VB
cord-332109-ont0tqpn	300	39	BBB	BBB	NNP
cord-332109-ont0tqpn	300	40	basement	basement	NN
cord-332109-ont0tqpn	300	41	membrane	membrane	NN
cord-332109-ont0tqpn	300	42	structure	structure	NN
cord-332109-ont0tqpn	300	43	[	[	-LRB-
cord-332109-ont0tqpn	300	44	178	178	CD
cord-332109-ont0tqpn	300	45	,	,	,
cord-332109-ont0tqpn	300	46	179	179	CD
cord-332109-ont0tqpn	300	47	]	]	-RRB-
cord-332109-ont0tqpn	300	48	.	.	.
cord-332109-ont0tqpn	301	1	METH	meth	NN
cord-332109-ont0tqpn	301	2	abuse	abuse	NN
cord-332109-ont0tqpn	301	3	has	have	VBZ
cord-332109-ont0tqpn	301	4	been	be	VBN
cord-332109-ont0tqpn	301	5	shown	show	VBN
cord-332109-ont0tqpn	301	6	to	to	TO
cord-332109-ont0tqpn	301	7	increase	increase	VB
cord-332109-ont0tqpn	301	8	brain	brain	NN
cord-332109-ont0tqpn	301	9	infection	infection	NN
cord-332109-ont0tqpn	301	10	of	of	IN
cord-332109-ont0tqpn	301	11	peripheral	peripheral	JJ
cord-332109-ont0tqpn	301	12	bacteria	bacteria	NNS
cord-332109-ont0tqpn	301	13	and	and	CC
cord-332109-ont0tqpn	301	14	viruses	virus	NNS
cord-332109-ont0tqpn	301	15	[	[	-LRB-
cord-332109-ont0tqpn	301	16	180	180	CD
cord-332109-ont0tqpn	301	17	]	]	-RRB-
cord-332109-ont0tqpn	301	18	[	[	-LRB-
cord-332109-ont0tqpn	301	19	181	181	CD
cord-332109-ont0tqpn	301	20	]	]	-RRB-
cord-332109-ont0tqpn	301	21	[	[	-LRB-
cord-332109-ont0tqpn	301	22	182	182	CD
cord-332109-ont0tqpn	301	23	]	]	-RRB-
cord-332109-ont0tqpn	301	24	.	.	.
cord-332109-ont0tqpn	302	1	Similarly	similarly	RB
cord-332109-ont0tqpn	302	2	,	,	,
cord-332109-ont0tqpn	302	3	MDMA	MDMA	NNP
cord-332109-ont0tqpn	302	4	has	have	VBZ
cord-332109-ont0tqpn	302	5	been	be	VBN
cord-332109-ont0tqpn	302	6	shown	show	VBN
cord-332109-ont0tqpn	302	7	to	to	TO
cord-332109-ont0tqpn	302	8	cause	cause	VB
cord-332109-ont0tqpn	302	9	BBB	BBB	NNP
cord-332109-ont0tqpn	302	10	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	302	11	with	with	IN
cord-332109-ont0tqpn	302	12	increased	increase	VBN
cord-332109-ont0tqpn	302	13	BBB	bbb	NN
cord-332109-ont0tqpn	302	14	permeability	permeability	NN
cord-332109-ont0tqpn	302	15	[	[	-LRB-
cord-332109-ont0tqpn	302	16	183	183	CD
cord-332109-ont0tqpn	302	17	]	]	-RRB-
cord-332109-ont0tqpn	302	18	,	,	,
cord-332109-ont0tqpn	302	19	and	and	CC
cord-332109-ont0tqpn	302	20	to	to	TO
cord-332109-ont0tqpn	302	21	excessively	excessively	RB
cord-332109-ont0tqpn	302	22	activate	activate	VB
cord-332109-ont0tqpn	302	23	astrocytes	astrocyte	NNS
cord-332109-ont0tqpn	302	24	and	and	CC
cord-332109-ont0tqpn	302	25	microglia	microglia	NNS
cord-332109-ont0tqpn	302	26	[	[	-LRB-
cord-332109-ont0tqpn	302	27	184	184	CD
cord-332109-ont0tqpn	302	28	]	]	-RRB-
cord-332109-ont0tqpn	302	29	.	.	.
cord-332109-ont0tqpn	303	1	It	-PRON-	PRP
cord-332109-ont0tqpn	303	2	may	may	MD
cord-332109-ont0tqpn	303	3	lead	lead	VB
cord-332109-ont0tqpn	303	4	to	to	IN
cord-332109-ont0tqpn	303	5	edema	edema	NN
cord-332109-ont0tqpn	303	6	[	[	-LRB-
cord-332109-ont0tqpn	303	7	183	183	CD
cord-332109-ont0tqpn	303	8	]	]	-RRB-
cord-332109-ont0tqpn	303	9	.	.	.
cord-332109-ont0tqpn	304	1	With	with	IN
cord-332109-ont0tqpn	304	2	BBB	BBB	NNP
cord-332109-ont0tqpn	304	3	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	304	4	,	,	,
cord-332109-ont0tqpn	304	5	it	-PRON-	PRP
cord-332109-ont0tqpn	304	6	is	be	VBZ
cord-332109-ont0tqpn	304	7	almost	almost	RB
cord-332109-ont0tqpn	304	8	certain	certain	JJ
cord-332109-ont0tqpn	304	9	that	that	IN
cord-332109-ont0tqpn	304	10	the	the	DT
cord-332109-ont0tqpn	304	11	risks	risk	NNS
cord-332109-ont0tqpn	304	12	of	of	IN
cord-332109-ont0tqpn	304	13	SARS	SARS	NNP
cord-332109-ont0tqpn	304	14	-	-	HYPH
cord-332109-ont0tqpn	304	15	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	304	16	invasion	invasion	NN
cord-332109-ont0tqpn	304	17	into	into	IN
cord-332109-ont0tqpn	304	18	the	the	DT
cord-332109-ont0tqpn	304	19	brain	brain	NN
cord-332109-ont0tqpn	304	20	will	will	MD
cord-332109-ont0tqpn	304	21	be	be	VB
cord-332109-ont0tqpn	304	22	immensely	immensely	RB
cord-332109-ont0tqpn	304	23	heightened	heighten	VBN
cord-332109-ont0tqpn	304	24	among	among	IN
cord-332109-ont0tqpn	304	25	individuals	individual	NNS
cord-332109-ont0tqpn	304	26	using	use	VBG
cord-332109-ont0tqpn	304	27	or	or	CC
cord-332109-ont0tqpn	304	28	abusing	abuse	VBG
cord-332109-ont0tqpn	304	29	these	these	DT
cord-332109-ont0tqpn	304	30	psychostimulants	psychostimulant	NNS
cord-332109-ont0tqpn	304	31	,	,	,
cord-332109-ont0tqpn	304	32	and	and	CC
cord-332109-ont0tqpn	304	33	complications	complication	NNS
cord-332109-ont0tqpn	304	34	in	in	IN
cord-332109-ont0tqpn	304	35	these	these	DT
cord-332109-ont0tqpn	304	36	patients	patient	NNS
cord-332109-ont0tqpn	304	37	are	be	VBP
cord-332109-ont0tqpn	304	38	vastly	vastly	RB
cord-332109-ont0tqpn	304	39	expected	expect	VBN
cord-332109-ont0tqpn	304	40	.	.	.
cord-332109-ont0tqpn	305	1	Neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	305	2	induced	induce	VBN
cord-332109-ont0tqpn	305	3	by	by	IN
cord-332109-ont0tqpn	305	4	METH	METH	NNP
cord-332109-ont0tqpn	305	5	and	and	CC
cord-332109-ont0tqpn	305	6	MDMA	MDMA	NNP
cord-332109-ont0tqpn	305	7	also	also	RB
cord-332109-ont0tqpn	305	8	plays	play	VBZ
cord-332109-ont0tqpn	305	9	a	a	DT
cord-332109-ont0tqpn	305	10	major	major	JJ
cord-332109-ont0tqpn	305	11	role	role	NN
cord-332109-ont0tqpn	305	12	in	in	IN
cord-332109-ont0tqpn	305	13	BBB	BBB	NNP
cord-332109-ont0tqpn	305	14	damage	damage	NN
cord-332109-ont0tqpn	305	15	and	and	CC
cord-332109-ont0tqpn	305	16	may	may	MD
cord-332109-ont0tqpn	305	17	deteriorate	deteriorate	VB
cord-332109-ont0tqpn	305	18	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	305	19	conditions	condition	NNS
cord-332109-ont0tqpn	305	20	.	.	.
cord-332109-ont0tqpn	306	1	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	306	2	patients	patient	NNS
cord-332109-ont0tqpn	306	3	exhibit	exhibit	VBP
cord-332109-ont0tqpn	306	4	abnormal	abnormal	JJ
cord-332109-ont0tqpn	306	5	immune	immune	JJ
cord-332109-ont0tqpn	306	6	responses	response	NNS
cord-332109-ont0tqpn	306	7	related	relate	VBN
cord-332109-ont0tqpn	306	8	to	to	IN
cord-332109-ont0tqpn	306	9	high	high	JJ
cord-332109-ont0tqpn	306	10	levels	level	NNS
cord-332109-ont0tqpn	306	11	of	of	IN
cord-332109-ont0tqpn	306	12	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	306	13	cytokines	cytokine	NNS
cord-332109-ont0tqpn	306	14	,	,	,
cord-332109-ont0tqpn	306	15	including	include	VBG
cord-332109-ont0tqpn	306	16	TNFα	TNFα	NNS
cord-332109-ont0tqpn	306	17	and	and	CC
cord-332109-ont0tqpn	307	1	IL-6	IL-6	NNP
cord-332109-ont0tqpn	307	2	.	.	.
cord-332109-ont0tqpn	307	3	METH	METH	NNS
cord-332109-ont0tqpn	307	4	significantly	significantly	RB
cord-332109-ont0tqpn	307	5	increases	increase	VBZ
cord-332109-ont0tqpn	307	6	the	the	DT
cord-332109-ont0tqpn	307	7	expression	expression	NN
cord-332109-ont0tqpn	307	8	of	of	IN
cord-332109-ont0tqpn	307	9	TNFα	TNFα	NNS
cord-332109-ont0tqpn	307	10	and	and	CC
cord-332109-ont0tqpn	307	11	IL-6	IL-6	NNP
cord-332109-ont0tqpn	307	12	in	in	IN
cord-332109-ont0tqpn	307	13	the	the	DT
cord-332109-ont0tqpn	307	14	hippocampus	hippocampus	NN
cord-332109-ont0tqpn	307	15	,	,	,
cord-332109-ont0tqpn	307	16	frontal	frontal	JJ
cord-332109-ont0tqpn	307	17	cortex	cortex	NN
cord-332109-ont0tqpn	307	18	,	,	,
cord-332109-ont0tqpn	307	19	and	and	CC
cord-332109-ont0tqpn	307	20	striatum	striatum	NN
cord-332109-ont0tqpn	307	21	[	[	-LRB-
cord-332109-ont0tqpn	307	22	185	185	CD
cord-332109-ont0tqpn	307	23	]	]	-RRB-
cord-332109-ont0tqpn	307	24	.	.	.
cord-332109-ont0tqpn	308	1	The	the	DT
cord-332109-ont0tqpn	308	2	expression	expression	NN
cord-332109-ont0tqpn	308	3	of	of	IN
cord-332109-ont0tqpn	308	4	these	these	DT
cord-332109-ont0tqpn	308	5	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	308	6	cytokines	cytokine	NNS
cord-332109-ont0tqpn	308	7	is	be	VBZ
cord-332109-ont0tqpn	308	8	linked	link	VBN
cord-332109-ont0tqpn	308	9	to	to	IN
cord-332109-ont0tqpn	308	10	METH	METH	NNP
cord-332109-ont0tqpn	308	11	-	-	HYPH
cord-332109-ont0tqpn	308	12	induced	induce	VBN
cord-332109-ont0tqpn	308	13	microglial	microglial	JJ
cord-332109-ont0tqpn	308	14	activation	activation	NN
cord-332109-ont0tqpn	308	15	[	[	-LRB-
cord-332109-ont0tqpn	308	16	186	186	CD
cord-332109-ont0tqpn	308	17	,	,	,
cord-332109-ont0tqpn	308	18	187	187	CD
cord-332109-ont0tqpn	308	19	]	]	-RRB-
cord-332109-ont0tqpn	308	20	.	.	.
cord-332109-ont0tqpn	309	1	MDMA	MDMA	NNP
cord-332109-ont0tqpn	309	2	also	also	RB
cord-332109-ont0tqpn	309	3	elevates	elevate	VBZ
cord-332109-ont0tqpn	309	4	the	the	DT
cord-332109-ont0tqpn	309	5	expression	expression	NN
cord-332109-ont0tqpn	309	6	of	of	IN
cord-332109-ont0tqpn	309	7	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	309	8	cytokines	cytokine	NNS
cord-332109-ont0tqpn	309	9	,	,	,
cord-332109-ont0tqpn	309	10	such	such	JJ
cord-332109-ont0tqpn	309	11	as	as	IN
cord-332109-ont0tqpn	309	12	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	309	13	,	,	,
cord-332109-ont0tqpn	309	14	in	in	IN
cord-332109-ont0tqpn	309	15	the	the	DT
cord-332109-ont0tqpn	309	16	brain	brain	NN
cord-332109-ont0tqpn	309	17	[	[	-LRB-
cord-332109-ont0tqpn	309	18	188	188	CD
cord-332109-ont0tqpn	309	19	]	]	-RRB-
cord-332109-ont0tqpn	309	20	.	.	.
cord-332109-ont0tqpn	310	1	The	the	DT
cord-332109-ont0tqpn	310	2	excessive	excessive	JJ
cord-332109-ont0tqpn	310	3	expression	expression	NN
cord-332109-ont0tqpn	310	4	of	of	IN
cord-332109-ont0tqpn	310	5	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	310	6	cytokines	cytokine	NNS
cord-332109-ont0tqpn	310	7	in	in	IN
cord-332109-ont0tqpn	310	8	brain	brain	NN
cord-332109-ont0tqpn	310	9	tissues	tissue	NNS
cord-332109-ont0tqpn	310	10	could	could	MD
cord-332109-ont0tqpn	310	11	further	far	RBR
cord-332109-ont0tqpn	310	12	damage	damage	VB
cord-332109-ont0tqpn	310	13	the	the	DT
cord-332109-ont0tqpn	310	14	BBB	bbb	NN
cord-332109-ont0tqpn	310	15	and	and	CC
cord-332109-ont0tqpn	310	16	cause	cause	VB
cord-332109-ont0tqpn	310	17	oxidative	oxidative	JJ
cord-332109-ont0tqpn	310	18	stress	stress	NN
cord-332109-ont0tqpn	310	19	[	[	-LRB-
cord-332109-ont0tqpn	310	20	78	78	CD
cord-332109-ont0tqpn	310	21	,	,	,
cord-332109-ont0tqpn	310	22	189	189	CD
cord-332109-ont0tqpn	310	23	]	]	-RRB-
cord-332109-ont0tqpn	310	24	.	.	.
cord-332109-ont0tqpn	311	1	Neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	311	2	poses	pose	VBZ
cord-332109-ont0tqpn	311	3	a	a	DT
cord-332109-ont0tqpn	311	4	major	major	JJ
cord-332109-ont0tqpn	311	5	risk	risk	NN
cord-332109-ont0tqpn	311	6	for	for	IN
cord-332109-ont0tqpn	311	7	individuals	individual	NNS
cord-332109-ont0tqpn	311	8	with	with	IN
cord-332109-ont0tqpn	311	9	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	311	10	.	.	.
cord-332109-ont0tqpn	312	1	Substances	substance	NNS
cord-332109-ont0tqpn	312	2	of	of	IN
cord-332109-ont0tqpn	312	3	abuse	abuse	NN
cord-332109-ont0tqpn	312	4	may	may	MD
cord-332109-ont0tqpn	312	5	lead	lead	VB
cord-332109-ont0tqpn	312	6	to	to	IN
cord-332109-ont0tqpn	312	7	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	312	8	complication	complication	NN
cord-332109-ont0tqpn	312	9	and	and	CC
cord-332109-ont0tqpn	312	10	severity	severity	NN
cord-332109-ont0tqpn	312	11	in	in	IN
cord-332109-ont0tqpn	312	12	several	several	JJ
cord-332109-ont0tqpn	312	13	ways	way	NNS
cord-332109-ont0tqpn	312	14	.	.	.
cord-332109-ont0tqpn	313	1	Smoking	smoke	VBG
cord-332109-ont0tqpn	313	2	tobacco	tobacco	NN
cord-332109-ont0tqpn	313	3	and	and	CC
cord-332109-ont0tqpn	313	4	marijuana	marijuana	NN
cord-332109-ont0tqpn	313	5	could	could	MD
cord-332109-ont0tqpn	313	6	cause	cause	VB
cord-332109-ont0tqpn	313	7	direct	direct	JJ
cord-332109-ont0tqpn	313	8	damage	damage	NN
cord-332109-ont0tqpn	313	9	to	to	IN
cord-332109-ont0tqpn	313	10	the	the	DT
cord-332109-ont0tqpn	313	11	respiratory	respiratory	JJ
cord-332109-ont0tqpn	313	12	system	system	NN
cord-332109-ont0tqpn	313	13	,	,	,
cord-332109-ont0tqpn	313	14	such	such	JJ
cord-332109-ont0tqpn	313	15	as	as	IN
cord-332109-ont0tqpn	313	16	COPD	COPD	NNP
cord-332109-ont0tqpn	313	17	.	.	.
cord-332109-ont0tqpn	314	1	Other	other	JJ
cord-332109-ont0tqpn	314	2	substances	substance	NNS
cord-332109-ont0tqpn	314	3	mostly	mostly	RB
cord-332109-ont0tqpn	314	4	work	work	VBP
cord-332109-ont0tqpn	314	5	through	through	IN
cord-332109-ont0tqpn	314	6	modulating	modulate	VBG
cord-332109-ont0tqpn	314	7	brain	brain	NN
cord-332109-ont0tqpn	314	8	and	and	CC
cord-332109-ont0tqpn	314	9	immune	immune	JJ
cord-332109-ont0tqpn	314	10	functions	function	NNS
cord-332109-ont0tqpn	314	11	,	,	,
cord-332109-ont0tqpn	314	12	including	include	VBG
cord-332109-ont0tqpn	314	13	the	the	DT
cord-332109-ont0tqpn	314	14	promotion	promotion	NN
cord-332109-ont0tqpn	314	15	of	of	IN
cord-332109-ont0tqpn	314	16	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	314	17	factors	factor	NNS
cord-332109-ont0tqpn	314	18	,	,	,
cord-332109-ont0tqpn	314	19	suppression	suppression	NN
cord-332109-ont0tqpn	314	20	of	of	IN
cord-332109-ont0tqpn	314	21	immune	immune	JJ
cord-332109-ont0tqpn	314	22	responses	response	NNS
cord-332109-ont0tqpn	314	23	,	,	,
cord-332109-ont0tqpn	314	24	and	and	CC
cord-332109-ont0tqpn	314	25	impairment	impairment	NN
cord-332109-ont0tqpn	314	26	of	of	IN
cord-332109-ont0tqpn	314	27	the	the	DT
cord-332109-ont0tqpn	314	28	BBB	BBB	NNP
cord-332109-ont0tqpn	314	29	.	.	.
cord-332109-ont0tqpn	315	1	Neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	315	2	induced	induce	VBN
cord-332109-ont0tqpn	315	3	by	by	IN
cord-332109-ont0tqpn	315	4	several	several	JJ
cord-332109-ont0tqpn	315	5	substances	substance	NNS
cord-332109-ont0tqpn	315	6	of	of	IN
cord-332109-ont0tqpn	315	7	abuse	abuse	NN
cord-332109-ont0tqpn	315	8	and	and	CC
cord-332109-ont0tqpn	315	9	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	315	10	activities	activity	NNS
cord-332109-ont0tqpn	315	11	caused	cause	VBN
cord-332109-ont0tqpn	315	12	by	by	IN
cord-332109-ont0tqpn	315	13	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	315	14	in	in	IN
cord-332109-ont0tqpn	315	15	the	the	DT
cord-332109-ont0tqpn	315	16	peripheral	peripheral	JJ
cord-332109-ont0tqpn	315	17	tissues	tissue	NNS
cord-332109-ont0tqpn	315	18	may	may	MD
cord-332109-ont0tqpn	315	19	mutually	mutually	RB
cord-332109-ont0tqpn	315	20	intensify	intensify	VB
cord-332109-ont0tqpn	315	21	the	the	DT
cord-332109-ont0tqpn	315	22	adverse	adverse	JJ
cord-332109-ont0tqpn	315	23	effects	effect	NNS
cord-332109-ont0tqpn	315	24	of	of	IN
cord-332109-ont0tqpn	315	25	one	one	CD
cord-332109-ont0tqpn	315	26	another	another	DT
cord-332109-ont0tqpn	315	27	,	,	,
cord-332109-ont0tqpn	315	28	leading	lead	VBG
cord-332109-ont0tqpn	315	29	to	to	IN
cord-332109-ont0tqpn	315	30	negative	negative	JJ
cord-332109-ont0tqpn	315	31	progression	progression	NN
cord-332109-ont0tqpn	315	32	of	of	IN
cord-332109-ont0tqpn	315	33	the	the	DT
cord-332109-ont0tqpn	315	34	disease	disease	NN
cord-332109-ont0tqpn	315	35	.	.	.
cord-332109-ont0tqpn	316	1	With	with	IN
cord-332109-ont0tqpn	316	2	impaired	impaired	JJ
cord-332109-ont0tqpn	316	3	HPA	HPA	NNP
cord-332109-ont0tqpn	316	4	axis	axis	NN
cord-332109-ont0tqpn	316	5	and	and	CC
cord-332109-ont0tqpn	316	6	immune	immune	JJ
cord-332109-ont0tqpn	316	7	imbalance	imbalance	NN
cord-332109-ont0tqpn	316	8	,	,	,
cord-332109-ont0tqpn	316	9	the	the	DT
cord-332109-ont0tqpn	316	10	patients	patient	NNS
cord-332109-ont0tqpn	316	11	are	be	VBP
cord-332109-ont0tqpn	316	12	highly	highly	RB
cord-332109-ont0tqpn	316	13	susceptible	susceptible	JJ
cord-332109-ont0tqpn	316	14	to	to	IN
cord-332109-ont0tqpn	316	15	SARS	SARS	NNP
cord-332109-ont0tqpn	316	16	-	-	HYPH
cord-332109-ont0tqpn	316	17	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	316	18	infections	infection	NNS
cord-332109-ont0tqpn	316	19	.	.	.
cord-332109-ont0tqpn	317	1	Compromised	compromised	JJ
cord-332109-ont0tqpn	317	2	BBB	BBB	NNP
cord-332109-ont0tqpn	317	3	may	may	MD
cord-332109-ont0tqpn	317	4	pose	pose	VB
cord-332109-ont0tqpn	317	5	a	a	DT
cord-332109-ont0tqpn	317	6	high	high	JJ
cord-332109-ont0tqpn	317	7	risk	risk	NN
cord-332109-ont0tqpn	317	8	of	of	IN
cord-332109-ont0tqpn	317	9	viral	viral	JJ
cord-332109-ont0tqpn	317	10	infection	infection	NN
cord-332109-ont0tqpn	317	11	in	in	IN
cord-332109-ont0tqpn	317	12	the	the	DT
cord-332109-ont0tqpn	317	13	brain	brain	NN
cord-332109-ont0tqpn	317	14	tissue	tissue	NN
cord-332109-ont0tqpn	317	15	.	.	.
cord-332109-ont0tqpn	318	1	Figure	figure	NN
cord-332109-ont0tqpn	318	2	4	4	CD
cord-332109-ont0tqpn	318	3	sketches	sketch	NNS
cord-332109-ont0tqpn	318	4	the	the	DT
cord-332109-ont0tqpn	318	5	possible	possible	JJ
cord-332109-ont0tqpn	318	6	pathological	pathological	JJ
cord-332109-ont0tqpn	318	7	effects	effect	NNS
cord-332109-ont0tqpn	318	8	of	of	IN
cord-332109-ont0tqpn	318	9	commonly	commonly	RB
cord-332109-ont0tqpn	318	10	abused	abuse	VBN
cord-332109-ont0tqpn	318	11	substances	substance	NNS
cord-332109-ont0tqpn	318	12	on	on	IN
cord-332109-ont0tqpn	318	13	various	various	JJ
cord-332109-ont0tqpn	318	14	tissues	tissue	NNS
cord-332109-ont0tqpn	318	15	and	and	CC
cord-332109-ont0tqpn	318	16	systems	system	NNS
cord-332109-ont0tqpn	318	17	and	and	CC
cord-332109-ont0tqpn	318	18	their	-PRON-	PRP$
cord-332109-ont0tqpn	318	19	connection	connection	NN
cord-332109-ont0tqpn	318	20	to	to	IN
cord-332109-ont0tqpn	318	21	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	318	22	complications	complication	NNS
cord-332109-ont0tqpn	318	23	.	.	.
cord-332109-ont0tqpn	319	1	These	these	DT
cord-332109-ont0tqpn	319	2	adverse	adverse	JJ
cord-332109-ont0tqpn	319	3	effects	effect	NNS
cord-332109-ont0tqpn	319	4	of	of	IN
cord-332109-ont0tqpn	319	5	these	these	DT
cord-332109-ont0tqpn	319	6	substances	substance	NNS
cord-332109-ont0tqpn	319	7	on	on	IN
cord-332109-ont0tqpn	319	8	the	the	DT
cord-332109-ont0tqpn	319	9	respiratory	respiratory	JJ
cord-332109-ont0tqpn	319	10	system	system	NN
cord-332109-ont0tqpn	319	11	,	,	,
cord-332109-ont0tqpn	319	12	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	319	13	system	system	NN
cord-332109-ont0tqpn	319	14	,	,	,
cord-332109-ont0tqpn	319	15	the	the	DT
cord-332109-ont0tqpn	319	16	immune	immune	JJ
cord-332109-ont0tqpn	319	17	system	system	NN
cord-332109-ont0tqpn	319	18	,	,	,
cord-332109-ont0tqpn	319	19	and	and	CC
cord-332109-ont0tqpn	319	20	the	the	DT
cord-332109-ont0tqpn	319	21	CNS	CNS	NNP
cord-332109-ont0tqpn	319	22	,	,	,
cord-332109-ont0tqpn	319	23	as	as	RB
cord-332109-ont0tqpn	319	24	well	well	RB
cord-332109-ont0tqpn	319	25	as	as	IN
cord-332109-ont0tqpn	319	26	their	-PRON-	PRP$
cord-332109-ont0tqpn	319	27	relations	relation	NNS
cord-332109-ont0tqpn	319	28	to	to	IN
cord-332109-ont0tqpn	319	29	the	the	DT
cord-332109-ont0tqpn	319	30	severity	severity	NN
cord-332109-ont0tqpn	319	31	and	and	CC
cord-332109-ont0tqpn	319	32	negative	negative	JJ
cord-332109-ont0tqpn	319	33	prognosis	prognosis	NN
cord-332109-ont0tqpn	319	34	of	of	IN
cord-332109-ont0tqpn	319	35	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	319	36	,	,	,
cord-332109-ont0tqpn	319	37	are	be	VBP
cord-332109-ont0tqpn	319	38	summarized	summarize	VBN
cord-332109-ont0tqpn	319	39	in	in	IN
cord-332109-ont0tqpn	319	40	Table	Table	NNP
cord-332109-ont0tqpn	319	41	3	3	CD
cord-332109-ont0tqpn	319	42	.	.	.
cord-332109-ont0tqpn	320	1	Pharmaceuticals	pharmaceutical	NNS
cord-332109-ont0tqpn	320	2	2020	2020	CD
cord-332109-ont0tqpn	320	3	,	,	,
cord-332109-ont0tqpn	320	4	13	13	CD
cord-332109-ont0tqpn	320	5	,	,	,
cord-332109-ont0tqpn	320	6	x	x	NN
cord-332109-ont0tqpn	320	7	FOR	for	IN
cord-332109-ont0tqpn	320	8	PEER	PEER	NNP
cord-332109-ont0tqpn	320	9	REVIEW	REVIEW	NNP
cord-332109-ont0tqpn	320	10	13	13	CD
cord-332109-ont0tqpn	320	11	of	of	IN
cord-332109-ont0tqpn	320	12	29	29	CD
cord-332109-ont0tqpn	320	13	adverse	adverse	JJ
cord-332109-ont0tqpn	320	14	effects	effect	NNS
cord-332109-ont0tqpn	320	15	of	of	IN
cord-332109-ont0tqpn	320	16	these	these	DT
cord-332109-ont0tqpn	320	17	substances	substance	NNS
cord-332109-ont0tqpn	320	18	on	on	IN
cord-332109-ont0tqpn	320	19	the	the	DT
cord-332109-ont0tqpn	320	20	respiratory	respiratory	JJ
cord-332109-ont0tqpn	320	21	system	system	NN
cord-332109-ont0tqpn	320	22	,	,	,
cord-332109-ont0tqpn	320	23	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	320	24	system	system	NN
cord-332109-ont0tqpn	320	25	,	,	,
cord-332109-ont0tqpn	320	26	the	the	DT
cord-332109-ont0tqpn	320	27	immune	immune	JJ
cord-332109-ont0tqpn	320	28	system	system	NN
cord-332109-ont0tqpn	320	29	,	,	,
cord-332109-ont0tqpn	320	30	and	and	CC
cord-332109-ont0tqpn	320	31	the	the	DT
cord-332109-ont0tqpn	320	32	CNS	CNS	NNP
cord-332109-ont0tqpn	320	33	,	,	,
cord-332109-ont0tqpn	320	34	as	as	RB
cord-332109-ont0tqpn	320	35	well	well	RB
cord-332109-ont0tqpn	320	36	as	as	IN
cord-332109-ont0tqpn	320	37	their	-PRON-	PRP$
cord-332109-ont0tqpn	320	38	relations	relation	NNS
cord-332109-ont0tqpn	320	39	to	to	IN
cord-332109-ont0tqpn	320	40	the	the	DT
cord-332109-ont0tqpn	320	41	severity	severity	NN
cord-332109-ont0tqpn	320	42	and	and	CC
cord-332109-ont0tqpn	320	43	negative	negative	JJ
cord-332109-ont0tqpn	320	44	prognosis	prognosis	NN
cord-332109-ont0tqpn	320	45	of	of	IN
cord-332109-ont0tqpn	320	46	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	320	47	,	,	,
cord-332109-ont0tqpn	320	48	are	be	VBP
cord-332109-ont0tqpn	320	49	summarized	summarize	VBN
cord-332109-ont0tqpn	320	50	in	in	IN
cord-332109-ont0tqpn	320	51	Table	Table	NNP
cord-332109-ont0tqpn	320	52	3	3	CD
cord-332109-ont0tqpn	320	53	.	.	.
cord-332109-ont0tqpn	320	54	 	 	_SP
cord-332109-ont0tqpn	321	1	Main	main	JJ
cord-332109-ont0tqpn	321	2	cause	cause	NN
cord-332109-ont0tqpn	321	3	of	of	IN
cord-332109-ont0tqpn	321	4	COPD	COPD	NNP
cord-332109-ont0tqpn	321	5	[	[	-LRB-
cord-332109-ont0tqpn	321	6	10	10	CD
cord-332109-ont0tqpn	321	7	,	,	,
cord-332109-ont0tqpn	321	8	11	11	CD
cord-332109-ont0tqpn	321	9	,	,	,
cord-332109-ont0tqpn	321	10	82	82	CD
cord-332109-ont0tqpn	321	11	]	]	-RRB-
cord-332109-ont0tqpn	321	12	Increased	increase	VBN
cord-332109-ont0tqpn	321	13	severity	severity	NN
cord-332109-ont0tqpn	321	14	and	and	CC
cord-332109-ont0tqpn	321	15	mortality	mortality	NN
cord-332109-ont0tqpn	321	16	[	[	-LRB-
cord-332109-ont0tqpn	321	17	13	13	CD
cord-332109-ont0tqpn	321	18	,	,	,
cord-332109-ont0tqpn	321	19	81	81	CD
cord-332109-ont0tqpn	321	20	]	]	-RRB-
cord-332109-ont0tqpn	321	21	Immune	immune	JJ
cord-332109-ont0tqpn	321	22	system	system	NN
cord-332109-ont0tqpn	321	23	Immune	immune	JJ
cord-332109-ont0tqpn	321	24	suppression	suppression	NN
cord-332109-ont0tqpn	321	25	,	,	,
cord-332109-ont0tqpn	321	26	Decreased	Decreased	NNP
cord-332109-ont0tqpn	321	27	CD8	CD8	NNP
cord-332109-ont0tqpn	321	28	+	+	CC
cord-332109-ont0tqpn	321	29	T	T	NNP
cord-332109-ont0tqpn	321	30	-	-	HYPH
cord-332109-ont0tqpn	321	31	cells	cell	NNS
cord-332109-ont0tqpn	321	32	[	[	-LRB-
cord-332109-ont0tqpn	321	33	83	83	CD
cord-332109-ont0tqpn	321	34	,	,	,
cord-332109-ont0tqpn	321	35	84	84	CD
cord-332109-ont0tqpn	321	36	]	]	-RRB-
cord-332109-ont0tqpn	321	37	Higher	high	JJR
cord-332109-ont0tqpn	321	38	infection	infection	NN
cord-332109-ont0tqpn	321	39	rate	rate	NN
cord-332109-ont0tqpn	321	40	[	[	-LRB-
cord-332109-ont0tqpn	321	41	85	85	CD
cord-332109-ont0tqpn	321	42	]	]	-RRB-
cord-332109-ont0tqpn	322	1	Increased	increase	VBN
cord-332109-ont0tqpn	322	2	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	322	3	cytokines	cytokine	NNS
cord-332109-ont0tqpn	322	4	(	(	-LRB-
cord-332109-ont0tqpn	322	5	TNFα	TNFα	NNS
cord-332109-ont0tqpn	322	6	,	,	,
cord-332109-ont0tqpn	322	7	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	322	8	,	,	,
cord-332109-ont0tqpn	322	9	IL-18	IL-18	NNP
cord-332109-ont0tqpn	322	10	)	)	-RRB-
cord-332109-ont0tqpn	322	11	and	and	CC
cord-332109-ont0tqpn	322	12	chemokines	chemokine	NNS
cord-332109-ont0tqpn	322	13	(	(	-LRB-
cord-332109-ont0tqpn	322	14	CCL2	CCL2	NNP
cord-332109-ont0tqpn	322	15	,	,	,
cord-332109-ont0tqpn	322	16	CCL8	CCL8	NNP
cord-332109-ont0tqpn	322	17	,	,	,
cord-332109-ont0tqpn	322	18	and	and	CC
cord-332109-ont0tqpn	322	19	CXC3CL1	CXC3CL1	NNP
cord-332109-ont0tqpn	322	20	)	)	-RRB-
cord-332109-ont0tqpn	322	21	;	;	,
cord-332109-ont0tqpn	322	22	decreased	decrease	VBD
cord-332109-ont0tqpn	322	23	anti	anti	JJ
cord-332109-ont0tqpn	322	24	-	-	JJ
cord-332109-ont0tqpn	322	25	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	322	26	factors	factor	NNS
cord-332109-ont0tqpn	322	27	,	,	,
cord-332109-ont0tqpn	322	28	Bcl6	Bcl6	NNP
cord-332109-ont0tqpn	322	29	,	,	,
cord-332109-ont0tqpn	322	30	IL-10	IL-10	NNP
cord-332109-ont0tqpn	322	31	,	,	,
cord-332109-ont0tqpn	322	32	and	and	CC
cord-332109-ont0tqpn	322	33	CCL25	CCL25	NNP
cord-332109-ont0tqpn	322	34	[	[	-LRB-
cord-332109-ont0tqpn	322	35	92	92	CD
cord-332109-ont0tqpn	322	36	]	]	-RRB-
cord-332109-ont0tqpn	322	37	Increased	increase	VBN
cord-332109-ont0tqpn	322	38	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	322	39	cytokines	cytokine	NNS
cord-332109-ont0tqpn	322	40	and	and	CC
cord-332109-ont0tqpn	322	41	chemokines	chemokine	NNS
cord-332109-ont0tqpn	322	42	,	,	,
cord-332109-ont0tqpn	322	43	TNFα	TNFα	NNS
cord-332109-ont0tqpn	322	44	,	,	,
cord-332109-ont0tqpn	322	45	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	322	46	,	,	,
cord-332109-ont0tqpn	322	47	IL-6	IL-6	NNP
cord-332109-ont0tqpn	322	48	[	[	-LRB-
cord-332109-ont0tqpn	322	49	61	61	CD
cord-332109-ont0tqpn	322	50	]	]	-RRB-
cord-332109-ont0tqpn	322	51	[	[	-LRB-
cord-332109-ont0tqpn	322	52	62	62	CD
cord-332109-ont0tqpn	322	53	]	]	-RRB-
cord-332109-ont0tqpn	322	54	[	[	-LRB-
cord-332109-ont0tqpn	322	55	63	63	CD
cord-332109-ont0tqpn	322	56	]	]	-RRB-
cord-332109-ont0tqpn	323	1	CNS	CNS	NNP
cord-332109-ont0tqpn	323	2	BBB	BBB	NNP
cord-332109-ont0tqpn	323	3	leakage	leakage	NN
cord-332109-ont0tqpn	323	4	through	through	IN
cord-332109-ont0tqpn	323	5	loss	loss	NN
cord-332109-ont0tqpn	323	6	of	of	IN
cord-332109-ont0tqpn	323	7	tight	tight	JJ
cord-332109-ont0tqpn	323	8	junction	junction	NN
cord-332109-ont0tqpn	323	9	proteins	protein	NNS
cord-332109-ont0tqpn	323	10	[	[	-LRB-
cord-332109-ont0tqpn	323	11	86	86	CD
cord-332109-ont0tqpn	323	12	]	]	-RRB-
cord-332109-ont0tqpn	324	1	[	[	-LRB-
cord-332109-ont0tqpn	324	2	87	87	CD
cord-332109-ont0tqpn	324	3	]	]	-RRB-
cord-332109-ont0tqpn	325	1	[	[	-LRB-
cord-332109-ont0tqpn	325	2	88	88	CD
cord-332109-ont0tqpn	325	3	]	]	-RRB-
cord-332109-ont0tqpn	325	4	[	[	-LRB-
cord-332109-ont0tqpn	325	5	89	89	CD
cord-332109-ont0tqpn	325	6	]	]	-RRB-
cord-332109-ont0tqpn	326	1	Endotheliitis	endotheliitis	NN
cord-332109-ont0tqpn	326	2	and	and	CC
cord-332109-ont0tqpn	326	3	CNS	cns	JJ
cord-332109-ont0tqpn	326	4	infection	infection	NN
cord-332109-ont0tqpn	326	5	[	[	-LRB-
cord-332109-ont0tqpn	326	6	53,55	53,55	CD
cord-332109-ont0tqpn	326	7	-	-	SYM
cord-332109-ont0tqpn	326	8	57	57	CD
cord-332109-ont0tqpn	326	9	]	]	-RRB-
cord-332109-ont0tqpn	327	1	Immune	immune	JJ
cord-332109-ont0tqpn	327	2	system	system	NN
cord-332109-ont0tqpn	327	3	Increased	increase	VBD
cord-332109-ont0tqpn	327	4	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	327	5	cytokines	cytokine	NNS
cord-332109-ont0tqpn	327	6	,	,	,
cord-332109-ont0tqpn	327	7	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	327	8	and	and	CC
cord-332109-ont0tqpn	327	9	IL-6	IL-6	NNP
cord-332109-ont0tqpn	327	10	,	,	,
cord-332109-ont0tqpn	327	11	and	and	CC
cord-332109-ont0tqpn	327	12	chemokine	chemokine	NN
cord-332109-ont0tqpn	327	13	CCL-2	CCL-2	NNP
cord-332109-ont0tqpn	327	14	Increased	increase	VBD
cord-332109-ont0tqpn	327	15	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	327	16	cytokines	cytokine	NNS
cord-332109-ont0tqpn	327	17	and	and	CC
cord-332109-ont0tqpn	327	18	Respiratory	respiratory	JJ
cord-332109-ont0tqpn	327	19	system	system	NN
cord-332109-ont0tqpn	327	20	Main	main	JJ
cord-332109-ont0tqpn	327	21	cause	cause	NN
cord-332109-ont0tqpn	327	22	of	of	IN
cord-332109-ont0tqpn	327	23	COPD	COPD	NNP
cord-332109-ont0tqpn	327	24	[	[	-LRB-
cord-332109-ont0tqpn	327	25	10	10	CD
cord-332109-ont0tqpn	327	26	,	,	,
cord-332109-ont0tqpn	327	27	11	11	CD
cord-332109-ont0tqpn	327	28	,	,	,
cord-332109-ont0tqpn	327	29	82	82	CD
cord-332109-ont0tqpn	327	30	]	]	-RRB-
cord-332109-ont0tqpn	328	1	Increased	increase	VBN
cord-332109-ont0tqpn	328	2	severity	severity	NN
cord-332109-ont0tqpn	328	3	and	and	CC
cord-332109-ont0tqpn	328	4	mortality	mortality	NN
cord-332109-ont0tqpn	328	5	[	[	-LRB-
cord-332109-ont0tqpn	328	6	13	13	CD
cord-332109-ont0tqpn	328	7	,	,	,
cord-332109-ont0tqpn	328	8	81	81	CD
cord-332109-ont0tqpn	328	9	]	]	-RRB-
cord-332109-ont0tqpn	328	10	Immune	immune	JJ
cord-332109-ont0tqpn	328	11	system	system	NN
cord-332109-ont0tqpn	328	12	Immune	immune	JJ
cord-332109-ont0tqpn	328	13	suppression	suppression	NN
cord-332109-ont0tqpn	328	14	,	,	,
cord-332109-ont0tqpn	328	15	Decreased	Decreased	NNP
cord-332109-ont0tqpn	328	16	CD8	CD8	NNP
cord-332109-ont0tqpn	328	17	+	+	CC
cord-332109-ont0tqpn	328	18	T	T	NNP
cord-332109-ont0tqpn	328	19	-	-	HYPH
cord-332109-ont0tqpn	328	20	cells	cell	NNS
cord-332109-ont0tqpn	328	21	[	[	-LRB-
cord-332109-ont0tqpn	328	22	83	83	CD
cord-332109-ont0tqpn	328	23	,	,	,
cord-332109-ont0tqpn	328	24	84	84	CD
cord-332109-ont0tqpn	328	25	]	]	-RRB-
cord-332109-ont0tqpn	328	26	Higher	high	JJR
cord-332109-ont0tqpn	328	27	infection	infection	NN
cord-332109-ont0tqpn	328	28	rate	rate	NN
cord-332109-ont0tqpn	328	29	[	[	-LRB-
cord-332109-ont0tqpn	328	30	85	85	CD
cord-332109-ont0tqpn	328	31	]	]	-RRB-
cord-332109-ont0tqpn	329	1	Increased	increase	VBN
cord-332109-ont0tqpn	329	2	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	329	3	cytokines	cytokine	NNS
cord-332109-ont0tqpn	329	4	(	(	-LRB-
cord-332109-ont0tqpn	329	5	TNFα	TNFα	NNS
cord-332109-ont0tqpn	329	6	,	,	,
cord-332109-ont0tqpn	329	7	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	329	8	,	,	,
cord-332109-ont0tqpn	329	9	IL-18	IL-18	NNP
cord-332109-ont0tqpn	329	10	)	)	-RRB-
cord-332109-ont0tqpn	329	11	and	and	CC
cord-332109-ont0tqpn	329	12	chemokines	chemokine	NNS
cord-332109-ont0tqpn	329	13	(	(	-LRB-
cord-332109-ont0tqpn	329	14	CCL2	CCL2	NNP
cord-332109-ont0tqpn	329	15	,	,	,
cord-332109-ont0tqpn	329	16	CCL8	CCL8	NNP
cord-332109-ont0tqpn	329	17	,	,	,
cord-332109-ont0tqpn	329	18	and	and	CC
cord-332109-ont0tqpn	329	19	CXC3CL1	CXC3CL1	NNP
cord-332109-ont0tqpn	329	20	)	)	-RRB-
cord-332109-ont0tqpn	329	21	;	;	,
cord-332109-ont0tqpn	329	22	decreased	decrease	VBD
cord-332109-ont0tqpn	329	23	anti	anti	JJ
cord-332109-ont0tqpn	329	24	-	-	JJ
cord-332109-ont0tqpn	329	25	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	329	26	factors	factor	NNS
cord-332109-ont0tqpn	329	27	,	,	,
cord-332109-ont0tqpn	329	28	Bcl6	Bcl6	NNP
cord-332109-ont0tqpn	329	29	,	,	,
cord-332109-ont0tqpn	329	30	IL-10	IL-10	NNP
cord-332109-ont0tqpn	329	31	,	,	,
cord-332109-ont0tqpn	329	32	and	and	CC
cord-332109-ont0tqpn	329	33	CCL25	CCL25	NNP
cord-332109-ont0tqpn	329	34	[	[	-LRB-
cord-332109-ont0tqpn	329	35	92	92	CD
cord-332109-ont0tqpn	329	36	]	]	-RRB-
cord-332109-ont0tqpn	329	37	Increased	increase	VBN
cord-332109-ont0tqpn	329	38	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	329	39	cytokines	cytokine	NNS
cord-332109-ont0tqpn	329	40	and	and	CC
cord-332109-ont0tqpn	329	41	chemokines	chemokine	NNS
cord-332109-ont0tqpn	329	42	,	,	,
cord-332109-ont0tqpn	329	43	TNFα	TNFα	NNS
cord-332109-ont0tqpn	329	44	,	,	,
cord-332109-ont0tqpn	329	45	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	329	46	,	,	,
cord-332109-ont0tqpn	329	47	IL-6	IL-6	NNP
cord-332109-ont0tqpn	329	48	[	[	-LRB-
cord-332109-ont0tqpn	329	49	61	61	CD
cord-332109-ont0tqpn	329	50	]	]	-RRB-
cord-332109-ont0tqpn	329	51	[	[	-LRB-
cord-332109-ont0tqpn	329	52	62	62	CD
cord-332109-ont0tqpn	329	53	]	]	-RRB-
cord-332109-ont0tqpn	329	54	[	[	-LRB-
cord-332109-ont0tqpn	329	55	63	63	CD
cord-332109-ont0tqpn	329	56	]	]	-RRB-
cord-332109-ont0tqpn	330	1	CNS	CNS	NNP
cord-332109-ont0tqpn	330	2	BBB	BBB	NNP
cord-332109-ont0tqpn	330	3	leakage	leakage	NN
cord-332109-ont0tqpn	330	4	through	through	IN
cord-332109-ont0tqpn	330	5	loss	loss	NN
cord-332109-ont0tqpn	330	6	of	of	IN
cord-332109-ont0tqpn	330	7	tight	tight	JJ
cord-332109-ont0tqpn	330	8	junction	junction	NN
cord-332109-ont0tqpn	330	9	proteins	protein	NNS
cord-332109-ont0tqpn	330	10	[	[	-LRB-
cord-332109-ont0tqpn	330	11	86	86	CD
cord-332109-ont0tqpn	330	12	]	]	-RRB-
cord-332109-ont0tqpn	331	1	[	[	-LRB-
cord-332109-ont0tqpn	331	2	87	87	CD
cord-332109-ont0tqpn	331	3	]	]	-RRB-
cord-332109-ont0tqpn	332	1	[	[	-LRB-
cord-332109-ont0tqpn	332	2	88	88	CD
cord-332109-ont0tqpn	332	3	]	]	-RRB-
cord-332109-ont0tqpn	332	4	[	[	-LRB-
cord-332109-ont0tqpn	332	5	89	89	CD
cord-332109-ont0tqpn	332	6	]	]	-RRB-
cord-332109-ont0tqpn	332	7	Endotheliitis	Endotheliitis	NNP
cord-332109-ont0tqpn	332	8	and	and	CC
cord-332109-ont0tqpn	332	9	CNS	cns	JJ
cord-332109-ont0tqpn	332	10	infection	infection	NN
cord-332109-ont0tqpn	332	11	[	[	-LRB-
cord-332109-ont0tqpn	332	12	53	53	CD
cord-332109-ont0tqpn	332	13	,	,	,
cord-332109-ont0tqpn	332	14	[	[	-LRB-
cord-332109-ont0tqpn	332	15	55	55	CD
cord-332109-ont0tqpn	332	16	]	]	-RRB-
cord-332109-ont0tqpn	332	17	[	[	-LRB-
cord-332109-ont0tqpn	332	18	56	56	CD
cord-332109-ont0tqpn	332	19	]	]	-RRB-
cord-332109-ont0tqpn	333	1	[	[	-LRB-
cord-332109-ont0tqpn	333	2	57	57	CD
cord-332109-ont0tqpn	333	3	]	]	-RRB-
cord-332109-ont0tqpn	334	1	Alcohol	alcohol	NN
cord-332109-ont0tqpn	334	2	Increased	increase	VBN
cord-332109-ont0tqpn	334	3	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	334	4	cytokines	cytokine	NNS
cord-332109-ont0tqpn	334	5	,	,	,
cord-332109-ont0tqpn	334	6	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	334	7	and	and	CC
cord-332109-ont0tqpn	334	8	IL-6	IL-6	NNP
cord-332109-ont0tqpn	334	9	,	,	,
cord-332109-ont0tqpn	334	10	and	and	CC
cord-332109-ont0tqpn	334	11	chemokine	chemokine	NN
cord-332109-ont0tqpn	335	1	CCL-2	CCL-2	NNP
cord-332109-ont0tqpn	336	1	[	[	-LRB-
cord-332109-ont0tqpn	336	2	98	98	CD
cord-332109-ont0tqpn	336	3	]	]	-RRB-
cord-332109-ont0tqpn	336	4	Increased	increase	VBN
cord-332109-ont0tqpn	336	5	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	336	6	cytokines	cytokine	NNS
cord-332109-ont0tqpn	336	7	and	and	CC
cord-332109-ont0tqpn	336	8	chemokines	chemokine	NNS
cord-332109-ont0tqpn	336	9	,	,	,
cord-332109-ont0tqpn	336	10	TNFα	TNFα	NNS
cord-332109-ont0tqpn	336	11	,	,	,
cord-332109-ont0tqpn	336	12	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	336	13	,	,	,
cord-332109-ont0tqpn	336	14	IL-6	IL-6	NNP
cord-332109-ont0tqpn	336	15	[	[	-LRB-
cord-332109-ont0tqpn	336	16	61	61	CD
cord-332109-ont0tqpn	336	17	]	]	-RRB-
cord-332109-ont0tqpn	336	18	[	[	-LRB-
cord-332109-ont0tqpn	336	19	62	62	CD
cord-332109-ont0tqpn	336	20	]	]	-RRB-
cord-332109-ont0tqpn	336	21	[	[	-LRB-
cord-332109-ont0tqpn	336	22	63	63	CD
cord-332109-ont0tqpn	336	23	]	]	-RRB-
cord-332109-ont0tqpn	337	1	Spleen	spleen	NN
cord-332109-ont0tqpn	337	2	atrophy	atrophy	NN
cord-332109-ont0tqpn	337	3	[	[	-LRB-
cord-332109-ont0tqpn	337	4	100	100	CD
cord-332109-ont0tqpn	337	5	]	]	-RRB-
cord-332109-ont0tqpn	337	6	.	.	.
cord-332109-ont0tqpn	338	1	Impaired	impaired	JJ
cord-332109-ont0tqpn	338	2	production	production	NN
cord-332109-ont0tqpn	338	3	of	of	IN
cord-332109-ont0tqpn	338	4	antibodies	antibody	NNS
cord-332109-ont0tqpn	338	5	and	and	CC
cord-332109-ont0tqpn	338	6	lymphocytes	lymphocyte	NNS
cord-332109-ont0tqpn	338	7	[	[	-LRB-
cord-332109-ont0tqpn	338	8	102	102	CD
cord-332109-ont0tqpn	338	9	]	]	-RRB-
cord-332109-ont0tqpn	338	10	CNS	CNS	NNP
cord-332109-ont0tqpn	338	11	Increased	increase	VBD
cord-332109-ont0tqpn	338	12	BBB	BBB	NNP
cord-332109-ont0tqpn	338	13	permeability	permeability	NN
cord-332109-ont0tqpn	338	14	through	through	IN
cord-332109-ont0tqpn	338	15	cytoskeletal	cytoskeletal	JJ
cord-332109-ont0tqpn	338	16	and	and	CC
cord-332109-ont0tqpn	338	17	tight	tight	JJ
cord-332109-ont0tqpn	338	18	junction	junction	NN
cord-332109-ont0tqpn	338	19	remodeling	remodeling	NN
cord-332109-ont0tqpn	338	20	[	[	-LRB-
cord-332109-ont0tqpn	338	21	103	103	CD
cord-332109-ont0tqpn	338	22	]	]	-RRB-
cord-332109-ont0tqpn	338	23	[	[	-LRB-
cord-332109-ont0tqpn	338	24	104	104	CD
cord-332109-ont0tqpn	338	25	]	]	-RRB-
cord-332109-ont0tqpn	338	26	[	[	-LRB-
cord-332109-ont0tqpn	338	27	105	105	CD
cord-332109-ont0tqpn	338	28	]	]	-RRB-
cord-332109-ont0tqpn	338	29	.	.	.
cord-332109-ont0tqpn	339	1	Endotheliitis	endotheliitis	NN
cord-332109-ont0tqpn	339	2	and	and	CC
cord-332109-ont0tqpn	339	3	CNS	cns	JJ
cord-332109-ont0tqpn	339	4	infection	infection	NN
cord-332109-ont0tqpn	339	5	[	[	-LRB-
cord-332109-ont0tqpn	339	6	53	53	CD
cord-332109-ont0tqpn	339	7	,	,	,
cord-332109-ont0tqpn	339	8	[	[	-LRB-
cord-332109-ont0tqpn	339	9	55	55	CD
cord-332109-ont0tqpn	339	10	]	]	-RRB-
cord-332109-ont0tqpn	339	11	[	[	-LRB-
cord-332109-ont0tqpn	339	12	56	56	CD
cord-332109-ont0tqpn	339	13	]	]	-RRB-
cord-332109-ont0tqpn	339	14	[	[	-LRB-
cord-332109-ont0tqpn	339	15	57	57	CD
cord-332109-ont0tqpn	339	16	]	]	-RRB-
cord-332109-ont0tqpn	339	17	Marijuana	Marijuana	NNP
cord-332109-ont0tqpn	339	18	(	(	-LRB-
cord-332109-ont0tqpn	339	19	THC	THC	NNP
cord-332109-ont0tqpn	339	20	,	,	,
cord-332109-ont0tqpn	339	21	CBD	CBD	NNP
cord-332109-ont0tqpn	339	22	)	)	-RRB-
cord-332109-ont0tqpn	340	1	Enhanced	enhanced	JJ
cord-332109-ont0tqpn	340	2	COPD	COPD	NNP
cord-332109-ont0tqpn	340	3	with	with	IN
cord-332109-ont0tqpn	340	4	tobacco	tobacco	NN
cord-332109-ont0tqpn	340	5	[	[	-LRB-
cord-332109-ont0tqpn	340	6	113	113	CD
cord-332109-ont0tqpn	340	7	,	,	,
cord-332109-ont0tqpn	340	8	114	114	CD
cord-332109-ont0tqpn	340	9	]	]	-RRB-
cord-332109-ont0tqpn	341	1	Increased	increase	VBN
cord-332109-ont0tqpn	341	2	severity	severity	NN
cord-332109-ont0tqpn	341	3	and	and	CC
cord-332109-ont0tqpn	341	4	mortality	mortality	NN
cord-332109-ont0tqpn	341	5	[	[	-LRB-
cord-332109-ont0tqpn	341	6	13	13	CD
cord-332109-ont0tqpn	341	7	,	,	,
cord-332109-ont0tqpn	341	8	81	81	CD
cord-332109-ont0tqpn	341	9	]	]	-RRB-
cord-332109-ont0tqpn	341	10	Immune	immune	JJ
cord-332109-ont0tqpn	341	11	system	system	NN
cord-332109-ont0tqpn	341	12	Immunosuppression	Immunosuppression	NNP
cord-332109-ont0tqpn	341	13	;	;	,
cord-332109-ont0tqpn	341	14	reduced	reduce	VBN
cord-332109-ont0tqpn	341	15	antibody	antibody	NN
cord-332109-ont0tqpn	341	16	response	response	NN
cord-332109-ont0tqpn	341	17	and	and	CC
cord-332109-ont0tqpn	341	18	T	t	NN
cord-332109-ont0tqpn	341	19	lymphocyte	lymphocyte	NN
cord-332109-ont0tqpn	341	20	activities	activity	NNS
cord-332109-ont0tqpn	341	21	;	;	,
cord-332109-ont0tqpn	341	22	reduced	reduce	VBN
cord-332109-ont0tqpn	341	23	migration	migration	NN
cord-332109-ont0tqpn	341	24	of	of	IN
cord-332109-ont0tqpn	341	25	macrophage	macrophage	NN
cord-332109-ont0tqpn	341	26	[	[	-LRB-
cord-332109-ont0tqpn	341	27	111	111	CD
cord-332109-ont0tqpn	341	28	]	]	-RRB-
cord-332109-ont0tqpn	341	29	Increased	increase	VBN
cord-332109-ont0tqpn	341	30	infection	infection	NN
cord-332109-ont0tqpn	341	31	and	and	CC
cord-332109-ont0tqpn	341	32	reduced	reduce	VBN
cord-332109-ont0tqpn	341	33	viral	viral	JJ
cord-332109-ont0tqpn	341	34	response	response	NN
cord-332109-ont0tqpn	341	35	and	and	CC
cord-332109-ont0tqpn	341	36	clearance	clearance	NN
cord-332109-ont0tqpn	341	37	[	[	-LRB-
cord-332109-ont0tqpn	341	38	111	111	CD
cord-332109-ont0tqpn	341	39	]	]	-RRB-
cord-332109-ont0tqpn	341	40	Opioids	opioid	NNS
cord-332109-ont0tqpn	341	41	(	(	-LRB-
cord-332109-ont0tqpn	341	42	heroine	heroine	NN
cord-332109-ont0tqpn	341	43	,	,	,
cord-332109-ont0tqpn	341	44	fentanyl	fentanyl	NN
cord-332109-ont0tqpn	341	45	,	,	,
cord-332109-ont0tqpn	341	46	morphine	morphine	NN
cord-332109-ont0tqpn	341	47	)	)	-RRB-
cord-332109-ont0tqpn	341	48	Respiratory	respiratory	JJ
cord-332109-ont0tqpn	341	49	system	system	NN
cord-332109-ont0tqpn	341	50	Respiratory	respiratory	JJ
cord-332109-ont0tqpn	341	51	depression	depression	NN
cord-332109-ont0tqpn	341	52	[	[	-LRB-
cord-332109-ont0tqpn	341	53	14	14	CD
cord-332109-ont0tqpn	341	54	,	,	,
cord-332109-ont0tqpn	341	55	15	15	CD
cord-332109-ont0tqpn	341	56	,	,	,
cord-332109-ont0tqpn	341	57	119	119	CD
cord-332109-ont0tqpn	341	58	]	]	-RRB-
cord-332109-ont0tqpn	341	59	Increased	increase	VBN
cord-332109-ont0tqpn	341	60	severity	severity	NN
cord-332109-ont0tqpn	341	61	and	and	CC
cord-332109-ont0tqpn	341	62	mortality	mortality	NN
cord-332109-ont0tqpn	341	63	[	[	-LRB-
cord-332109-ont0tqpn	341	64	14	14	CD
cord-332109-ont0tqpn	341	65	,	,	,
cord-332109-ont0tqpn	341	66	15	15	CD
cord-332109-ont0tqpn	341	67	]	]	-RRB-
cord-332109-ont0tqpn	341	68	Immune	immune	JJ
cord-332109-ont0tqpn	341	69	system	system	NN
cord-332109-ont0tqpn	341	70	Desensitizing	desensitize	VBG
cord-332109-ont0tqpn	341	71	HPA	HPA	NNP
cord-332109-ont0tqpn	341	72	axis	axis	NN
cord-332109-ont0tqpn	341	73	;	;	,
cord-332109-ont0tqpn	341	74	inhibiting	inhibit	VBG
cord-332109-ont0tqpn	341	75	glucocorticoid	glucocorticoid	NN
cord-332109-ont0tqpn	341	76	release	release	NN
cord-332109-ont0tqpn	341	77	,	,	,
cord-332109-ont0tqpn	341	78	increased	increase	VBN
cord-332109-ont0tqpn	341	79	IL-1β	il-1β	NN
cord-332109-ont0tqpn	341	80	;	;	:
cord-332109-ont0tqpn	341	81	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	341	82	[	[	-LRB-
cord-332109-ont0tqpn	341	83	120	120	CD
cord-332109-ont0tqpn	341	84	]	]	-RRB-
cord-332109-ont0tqpn	341	85	Increased	increase	VBN
cord-332109-ont0tqpn	341	86	opportunistic	opportunistic	JJ
cord-332109-ont0tqpn	341	87	infections	infection	NNS
cord-332109-ont0tqpn	341	88	,	,	,
cord-332109-ont0tqpn	341	89	excessive	excessive	JJ
cord-332109-ont0tqpn	341	90	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	341	91	response	response	NN
cord-332109-ont0tqpn	341	92	[	[	-LRB-
cord-332109-ont0tqpn	341	93	117	117	CD
cord-332109-ont0tqpn	341	94	,	,	,
cord-332109-ont0tqpn	341	95	118	118	CD
cord-332109-ont0tqpn	341	96	,	,	,
cord-332109-ont0tqpn	341	97	121	121	CD
cord-332109-ont0tqpn	341	98	]	]	-RRB-
cord-332109-ont0tqpn	341	99	Cocaine	Cocaine	NNP
cord-332109-ont0tqpn	341	100	Cardiac	Cardiac	NNP
cord-332109-ont0tqpn	341	101	arrhythmias	arrhythmia	NNS
cord-332109-ont0tqpn	341	102	and	and	CC
cord-332109-ont0tqpn	341	103	acute	acute	JJ
cord-332109-ont0tqpn	341	104	MI	mi	NN
cord-332109-ont0tqpn	341	105	;	;	:
cord-332109-ont0tqpn	341	106	oxygen	oxygen	NN
cord-332109-ont0tqpn	341	107	imbalance	imbalance	NN
cord-332109-ont0tqpn	341	108	;	;	:
cord-332109-ont0tqpn	341	109	microvascular	microvascular	JJ
cord-332109-ont0tqpn	341	110	diseases	disease	NNS
cord-332109-ont0tqpn	341	111	and	and	CC
cord-332109-ont0tqpn	341	112	thrombosis	thrombosis	NN
cord-332109-ont0tqpn	341	113	[	[	-LRB-
cord-332109-ont0tqpn	341	114	122	122	CD
cord-332109-ont0tqpn	341	115	]	]	-RRB-
cord-332109-ont0tqpn	341	116	[	[	-LRB-
cord-332109-ont0tqpn	341	117	123	123	CD
cord-332109-ont0tqpn	341	118	]	]	-RRB-
cord-332109-ont0tqpn	341	119	[	[	-LRB-
cord-332109-ont0tqpn	341	120	124	124	CD
cord-332109-ont0tqpn	341	121	]	]	-RRB-
cord-332109-ont0tqpn	341	122	[	[	-LRB-
cord-332109-ont0tqpn	341	123	125	125	CD
cord-332109-ont0tqpn	341	124	]	]	-RRB-
cord-332109-ont0tqpn	341	125	[	[	-LRB-
cord-332109-ont0tqpn	341	126	126	126	CD
cord-332109-ont0tqpn	341	127	]	]	-RRB-
cord-332109-ont0tqpn	341	128	[	[	-LRB-
cord-332109-ont0tqpn	341	129	127	127	CD
cord-332109-ont0tqpn	341	130	]	]	-RRB-
cord-332109-ont0tqpn	341	131	[	[	-LRB-
cord-332109-ont0tqpn	341	132	129	129	CD
cord-332109-ont0tqpn	341	133	]	]	-RRB-
cord-332109-ont0tqpn	341	134	[	[	-LRB-
cord-332109-ont0tqpn	341	135	130	130	CD
cord-332109-ont0tqpn	341	136	]	]	-RRB-
cord-332109-ont0tqpn	341	137	[	[	-LRB-
cord-332109-ont0tqpn	341	138	131	131	CD
cord-332109-ont0tqpn	341	139	]	]	-RRB-
cord-332109-ont0tqpn	342	1	[	[	-LRB-
cord-332109-ont0tqpn	342	2	132	132	CD
cord-332109-ont0tqpn	342	3	]	]	-RRB-
cord-332109-ont0tqpn	342	4	Increased	increase	VBN
cord-332109-ont0tqpn	342	5	severity	severity	NN
cord-332109-ont0tqpn	342	6	and	and	CC
cord-332109-ont0tqpn	342	7	mortality	mortality	NN
cord-332109-ont0tqpn	342	8	[	[	-LRB-
cord-332109-ont0tqpn	342	9	12	12	CD
cord-332109-ont0tqpn	342	10	,	,	,
cord-332109-ont0tqpn	342	11	37	37	CD
cord-332109-ont0tqpn	342	12	,	,	,
cord-332109-ont0tqpn	342	13	38	38	CD
cord-332109-ont0tqpn	342	14	]	]	-RRB-
cord-332109-ont0tqpn	342	15	Immune	immune	JJ
cord-332109-ont0tqpn	342	16	system	system	NN
cord-332109-ont0tqpn	342	17	Stimulating	stimulate	VBG
cord-332109-ont0tqpn	342	18	HPA	HPA	NNP
cord-332109-ont0tqpn	342	19	axis	axis	NN
cord-332109-ont0tqpn	342	20	;	;	:
cord-332109-ont0tqpn	342	21	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	342	22	;	;	:
cord-332109-ont0tqpn	342	23	defects	defect	NNS
cord-332109-ont0tqpn	342	24	in	in	IN
cord-332109-ont0tqpn	342	25	antibody	antibody	NN
cord-332109-ont0tqpn	342	26	formation	formation	NN
cord-332109-ont0tqpn	342	27	,	,	,
cord-332109-ont0tqpn	342	28	lymphocyte	lymphocyte	NN
cord-332109-ont0tqpn	342	29	proliferation	proliferation	NN
cord-332109-ont0tqpn	342	30	,	,	,
cord-332109-ont0tqpn	342	31	macrophage	macrophage	NN
cord-332109-ont0tqpn	342	32	and	and	CC
cord-332109-ont0tqpn	342	33	NK	NK	NNP
cord-332109-ont0tqpn	342	34	activation	activation	NN
cord-332109-ont0tqpn	342	35	[	[	-LRB-
cord-332109-ont0tqpn	342	36	141	141	CD
cord-332109-ont0tqpn	342	37	,	,	,
cord-332109-ont0tqpn	342	38	142	142	CD
cord-332109-ont0tqpn	342	39	]	]	-RRB-
cord-332109-ont0tqpn	342	40	High	high	JJ
cord-332109-ont0tqpn	342	41	incidence	incidence	NN
cord-332109-ont0tqpn	342	42	of	of	IN
cord-332109-ont0tqpn	342	43	viral	viral	JJ
cord-332109-ont0tqpn	342	44	infection	infection	NN
cord-332109-ont0tqpn	342	45	[	[	-LRB-
cord-332109-ont0tqpn	342	46	142	142	CD
cord-332109-ont0tqpn	342	47	]	]	-RRB-
cord-332109-ont0tqpn	342	48	CNS	CNS	NNP
cord-332109-ont0tqpn	342	49	Increased	increase	VBN
cord-332109-ont0tqpn	342	50	BBB	BBB	NNP
cord-332109-ont0tqpn	342	51	permeability	permeability	NN
cord-332109-ont0tqpn	342	52	due	due	JJ
cord-332109-ont0tqpn	342	53	to	to	IN
cord-332109-ont0tqpn	342	54	loss	loss	NN
cord-332109-ont0tqpn	342	55	of	of	IN
cord-332109-ont0tqpn	342	56	tight	tight	JJ
cord-332109-ont0tqpn	342	57	junction	junction	NN
cord-332109-ont0tqpn	342	58	proteins	protein	NNS
cord-332109-ont0tqpn	342	59	;	;	:
cord-332109-ont0tqpn	342	60	rearrangement	rearrangement	NN
cord-332109-ont0tqpn	342	61	of	of	IN
cord-332109-ont0tqpn	342	62	cytoskeleton	cytoskeleton	NN
cord-332109-ont0tqpn	342	63	structure	structure	NN
cord-332109-ont0tqpn	342	64	[	[	-LRB-
cord-332109-ont0tqpn	342	65	143	143	CD
cord-332109-ont0tqpn	342	66	]	]	-RRB-
cord-332109-ont0tqpn	342	67	[	[	-LRB-
cord-332109-ont0tqpn	342	68	144	144	CD
cord-332109-ont0tqpn	342	69	]	]	-RRB-
cord-332109-ont0tqpn	342	70	[	[	-LRB-
cord-332109-ont0tqpn	342	71	145	145	CD
cord-332109-ont0tqpn	342	72	]	]	-RRB-
cord-332109-ont0tqpn	342	73	[	[	-LRB-
cord-332109-ont0tqpn	342	74	146	146	CD
cord-332109-ont0tqpn	342	75	]	]	-RRB-
cord-332109-ont0tqpn	342	76	Endotheliitis	Endotheliitis	NNP
cord-332109-ont0tqpn	342	77	and	and	CC
cord-332109-ont0tqpn	342	78	CNS	cns	JJ
cord-332109-ont0tqpn	342	79	infection	infection	NN
cord-332109-ont0tqpn	342	80	[	[	-LRB-
cord-332109-ont0tqpn	342	81	53	53	CD
cord-332109-ont0tqpn	342	82	,	,	,
cord-332109-ont0tqpn	342	83	[	[	-LRB-
cord-332109-ont0tqpn	342	84	55	55	CD
cord-332109-ont0tqpn	342	85	]	]	-RRB-
cord-332109-ont0tqpn	342	86	[	[	-LRB-
cord-332109-ont0tqpn	342	87	56	56	CD
cord-332109-ont0tqpn	342	88	]	]	-RRB-
cord-332109-ont0tqpn	342	89	[	[	-LRB-
cord-332109-ont0tqpn	342	90	57	57	CD
cord-332109-ont0tqpn	342	91	]	]	-RRB-
cord-332109-ont0tqpn	343	1	Amphetamine	Amphetamine	NNP
cord-332109-ont0tqpn	343	2	,	,	,
cord-332109-ont0tqpn	343	3	METH	METH	NNP
cord-332109-ont0tqpn	343	4	,	,	,
cord-332109-ont0tqpn	343	5	MDMA	MDMA	NNP
cord-332109-ont0tqpn	343	6	Hypertension	Hypertension	NNP
cord-332109-ont0tqpn	343	7	,	,	,
cord-332109-ont0tqpn	343	8	tachycardia	tachycardia	NN
cord-332109-ont0tqpn	343	9	,	,	,
cord-332109-ont0tqpn	343	10	and	and	CC
cord-332109-ont0tqpn	343	11	cardiomyopathy	cardiomyopathy	NN
cord-332109-ont0tqpn	343	12	leading	lead	VBG
cord-332109-ont0tqpn	343	13	to	to	IN
cord-332109-ont0tqpn	343	14	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	343	15	edema	edema	NN
cord-332109-ont0tqpn	343	16	[	[	-LRB-
cord-332109-ont0tqpn	343	17	16	16	CD
cord-332109-ont0tqpn	343	18	,	,	,
cord-332109-ont0tqpn	343	19	163	163	CD
cord-332109-ont0tqpn	343	20	]	]	-RRB-
cord-332109-ont0tqpn	343	21	;	;	:
cord-332109-ont0tqpn	343	22	Ischemic	ischemic	JJ
cord-332109-ont0tqpn	343	23	stroke	stroke	NN
cord-332109-ont0tqpn	343	24	and	and	CC
cord-332109-ont0tqpn	343	25	hypoxia	hypoxia	NN
cord-332109-ont0tqpn	343	26	;	;	,
cord-332109-ont0tqpn	343	27	restricted	restrict	VBN
cord-332109-ont0tqpn	343	28	blood	blood	NN
cord-332109-ont0tqpn	343	29	flow	flow	NN
cord-332109-ont0tqpn	343	30	[	[	-LRB-
cord-332109-ont0tqpn	343	31	171	171	CD
cord-332109-ont0tqpn	343	32	]	]	-RRB-
cord-332109-ont0tqpn	343	33	[	[	-LRB-
cord-332109-ont0tqpn	343	34	172	172	CD
cord-332109-ont0tqpn	343	35	]	]	-RRB-
cord-332109-ont0tqpn	343	36	[	[	-LRB-
cord-332109-ont0tqpn	343	37	173	173	CD
cord-332109-ont0tqpn	343	38	]	]	-RRB-
cord-332109-ont0tqpn	343	39	[	[	-LRB-
cord-332109-ont0tqpn	343	40	174	174	CD
cord-332109-ont0tqpn	343	41	]	]	-RRB-
cord-332109-ont0tqpn	343	42	Increased	increase	VBN
cord-332109-ont0tqpn	343	43	severity	severity	NN
cord-332109-ont0tqpn	343	44	and	and	CC
cord-332109-ont0tqpn	343	45	mortality	mortality	NN
cord-332109-ont0tqpn	343	46	[	[	-LRB-
cord-332109-ont0tqpn	343	47	12	12	CD
cord-332109-ont0tqpn	343	48	,	,	,
cord-332109-ont0tqpn	343	49	37	37	CD
cord-332109-ont0tqpn	343	50	,	,	,
cord-332109-ont0tqpn	343	51	38	38	CD
cord-332109-ont0tqpn	343	52	]	]	-RRB-
cord-332109-ont0tqpn	343	53	Immune	immune	JJ
cord-332109-ont0tqpn	343	54	system	system	NN
cord-332109-ont0tqpn	343	55	Altered	alter	VBD
cord-332109-ont0tqpn	343	56	HPA	HPA	NNP
cord-332109-ont0tqpn	343	57	axis	axis	NN
cord-332109-ont0tqpn	343	58	,	,	,
cord-332109-ont0tqpn	343	59	impairing	impair	VBG
cord-332109-ont0tqpn	343	60	GR	GR	NNP
cord-332109-ont0tqpn	343	61	and	and	CC
cord-332109-ont0tqpn	343	62	MR	MR	NNP
cord-332109-ont0tqpn	343	63	expression	expression	NN
cord-332109-ont0tqpn	343	64	,	,	,
cord-332109-ont0tqpn	343	65	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	343	66	[	[	-LRB-
cord-332109-ont0tqpn	343	67	164	164	CD
cord-332109-ont0tqpn	343	68	]	]	-RRB-
cord-332109-ont0tqpn	343	69	[	[	-LRB-
cord-332109-ont0tqpn	343	70	165	165	CD
cord-332109-ont0tqpn	343	71	]	]	-RRB-
cord-332109-ont0tqpn	343	72	[	[	-LRB-
cord-332109-ont0tqpn	343	73	166	166	CD
cord-332109-ont0tqpn	343	74	]	]	-RRB-
cord-332109-ont0tqpn	343	75	[	[	-LRB-
cord-332109-ont0tqpn	343	76	167	167	CD
cord-332109-ont0tqpn	343	77	]	]	-RRB-
cord-332109-ont0tqpn	343	78	Increased	increase	VBN
cord-332109-ont0tqpn	343	79	infection	infection	NN
cord-332109-ont0tqpn	343	80	rate	rate	NN
cord-332109-ont0tqpn	343	81	,	,	,
cord-332109-ont0tqpn	343	82	depression	depression	NN
cord-332109-ont0tqpn	343	83	,	,	,
cord-332109-ont0tqpn	343	84	anxiety	anxiety	NN
cord-332109-ont0tqpn	343	85	/	/	SYM
cord-332109-ont0tqpn	343	86	despair	despair	NN
cord-332109-ont0tqpn	343	87	[	[	-LRB-
cord-332109-ont0tqpn	343	88	168	168	CD
cord-332109-ont0tqpn	343	89	,	,	,
cord-332109-ont0tqpn	343	90	169	169	CD
cord-332109-ont0tqpn	343	91	]	]	-RRB-
cord-332109-ont0tqpn	343	92	Increased	increase	VBN
cord-332109-ont0tqpn	343	93	expression	expression	NN
cord-332109-ont0tqpn	343	94	of	of	IN
cord-332109-ont0tqpn	343	95	TNFα	TNFα	NNS
cord-332109-ont0tqpn	343	96	,	,	,
cord-332109-ont0tqpn	343	97	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	343	98	,	,	,
cord-332109-ont0tqpn	343	99	and	and	CC
cord-332109-ont0tqpn	343	100	IL-6	IL-6	NNP
cord-332109-ont0tqpn	343	101	;	;	:
cord-332109-ont0tqpn	343	102	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	343	103	[	[	-LRB-
cord-332109-ont0tqpn	343	104	185	185	CD
cord-332109-ont0tqpn	343	105	]	]	-RRB-
cord-332109-ont0tqpn	343	106	[	[	-LRB-
cord-332109-ont0tqpn	343	107	186	186	CD
cord-332109-ont0tqpn	343	108	]	]	-RRB-
cord-332109-ont0tqpn	343	109	[	[	-LRB-
cord-332109-ont0tqpn	343	110	187	187	CD
cord-332109-ont0tqpn	343	111	]	]	-RRB-
cord-332109-ont0tqpn	344	1	[	[	-LRB-
cord-332109-ont0tqpn	344	2	188	188	CD
cord-332109-ont0tqpn	344	3	]	]	-RRB-
cord-332109-ont0tqpn	344	4	Excessive	excessive	JJ
cord-332109-ont0tqpn	344	5	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	344	6	response	response	NN
cord-332109-ont0tqpn	344	7	[	[	-LRB-
cord-332109-ont0tqpn	344	8	61	61	CD
cord-332109-ont0tqpn	344	9	]	]	-RRB-
cord-332109-ont0tqpn	344	10	[	[	-LRB-
cord-332109-ont0tqpn	344	11	62	62	CD
cord-332109-ont0tqpn	344	12	]	]	-RRB-
cord-332109-ont0tqpn	344	13	[	[	-LRB-
cord-332109-ont0tqpn	344	14	63	63	CD
cord-332109-ont0tqpn	344	15	]	]	-RRB-
cord-332109-ont0tqpn	345	1	CNS	CNS	NNP
cord-332109-ont0tqpn	345	2	BBB	BBB	NNP
cord-332109-ont0tqpn	345	3	damage	damage	NN
cord-332109-ont0tqpn	345	4	due	due	JJ
cord-332109-ont0tqpn	345	5	to	to	IN
cord-332109-ont0tqpn	345	6	loss	loss	NN
cord-332109-ont0tqpn	345	7	of	of	IN
cord-332109-ont0tqpn	345	8	tight	tight	JJ
cord-332109-ont0tqpn	345	9	junction	junction	NN
cord-332109-ont0tqpn	345	10	protein	protein	NN
cord-332109-ont0tqpn	345	11	;	;	:
cord-332109-ont0tqpn	345	12	edema	edema	NN
cord-332109-ont0tqpn	345	13	[	[	-LRB-
cord-332109-ont0tqpn	345	14	175	175	CD
cord-332109-ont0tqpn	345	15	]	]	-RRB-
cord-332109-ont0tqpn	345	16	[	[	-LRB-
cord-332109-ont0tqpn	345	17	176	176	CD
cord-332109-ont0tqpn	345	18	]	]	-RRB-
cord-332109-ont0tqpn	345	19	[	[	-LRB-
cord-332109-ont0tqpn	345	20	177	177	CD
cord-332109-ont0tqpn	345	21	]	]	-RRB-
cord-332109-ont0tqpn	345	22	[	[	-LRB-
cord-332109-ont0tqpn	345	23	178	178	CD
cord-332109-ont0tqpn	345	24	]	]	-RRB-
cord-332109-ont0tqpn	345	25	[	[	-LRB-
cord-332109-ont0tqpn	345	26	179	179	CD
cord-332109-ont0tqpn	345	27	]	]	-RRB-
cord-332109-ont0tqpn	345	28	Endotheliitis	Endotheliitis	NNP
cord-332109-ont0tqpn	345	29	and	and	CC
cord-332109-ont0tqpn	345	30	CNS	cns	JJ
cord-332109-ont0tqpn	345	31	infection	infection	NN
cord-332109-ont0tqpn	345	32	[	[	-LRB-
cord-332109-ont0tqpn	345	33	53	53	CD
cord-332109-ont0tqpn	345	34	,	,	,
cord-332109-ont0tqpn	345	35	[	[	-LRB-
cord-332109-ont0tqpn	345	36	55	55	CD
cord-332109-ont0tqpn	345	37	]	]	-RRB-
cord-332109-ont0tqpn	345	38	[	[	-LRB-
cord-332109-ont0tqpn	345	39	56	56	CD
cord-332109-ont0tqpn	345	40	]	]	-RRB-
cord-332109-ont0tqpn	345	41	[	[	-LRB-
cord-332109-ont0tqpn	345	42	57	57	CD
cord-332109-ont0tqpn	345	43	]	]	-RRB-
cord-332109-ont0tqpn	345	44	[	[	-LRB-
cord-332109-ont0tqpn	345	45	180	180	CD
cord-332109-ont0tqpn	345	46	]	]	-RRB-
cord-332109-ont0tqpn	345	47	[	[	-LRB-
cord-332109-ont0tqpn	345	48	181	181	CD
cord-332109-ont0tqpn	345	49	]	]	-RRB-
cord-332109-ont0tqpn	345	50	[	[	-LRB-
cord-332109-ont0tqpn	345	51	182	182	CD
cord-332109-ont0tqpn	345	52	]	]	-RRB-
cord-332109-ont0tqpn	345	53	 	 	_SP
cord-332109-ont0tqpn	346	1	The	the	DT
cord-332109-ont0tqpn	346	2	therapeutic	therapeutic	JJ
cord-332109-ont0tqpn	346	3	strategies	strategy	NNS
cord-332109-ont0tqpn	346	4	for	for	IN
cord-332109-ont0tqpn	346	5	COVID-19	covid-19	CD
cord-332109-ont0tqpn	346	6	have	have	VBP
cord-332109-ont0tqpn	346	7	been	be	VBN
cord-332109-ont0tqpn	346	8	focused	focus	VBN
cord-332109-ont0tqpn	346	9	on	on	IN
cord-332109-ont0tqpn	346	10	repurposing	repurpose	VBG
cord-332109-ont0tqpn	346	11	existing	exist	VBG
cord-332109-ont0tqpn	346	12	drugs	drug	NNS
cord-332109-ont0tqpn	346	13	against	against	IN
cord-332109-ont0tqpn	346	14	this	this	DT
cord-332109-ont0tqpn	346	15	novel	novel	JJ
cord-332109-ont0tqpn	346	16	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	346	17	[	[	-LRB-
cord-332109-ont0tqpn	346	18	190	190	CD
cord-332109-ont0tqpn	346	19	]	]	-RRB-
cord-332109-ont0tqpn	346	20	[	[	-LRB-
cord-332109-ont0tqpn	346	21	191	191	CD
cord-332109-ont0tqpn	346	22	]	]	-RRB-
cord-332109-ont0tqpn	346	23	[	[	-LRB-
cord-332109-ont0tqpn	346	24	192	192	CD
cord-332109-ont0tqpn	346	25	]	]	-RRB-
cord-332109-ont0tqpn	346	26	.	.	.
cord-332109-ont0tqpn	347	1	Among	among	IN
cord-332109-ont0tqpn	347	2	these	these	DT
cord-332109-ont0tqpn	347	3	repurposed	repurpose	VBN
cord-332109-ont0tqpn	347	4	drugs	drug	NNS
cord-332109-ont0tqpn	347	5	,	,	,
cord-332109-ont0tqpn	347	6	the	the	DT
cord-332109-ont0tqpn	347	7	antimalaria	antimalaria	NNP
cord-332109-ont0tqpn	347	8	drugs	drugs	NNPS
cord-332109-ont0tqpn	347	9	chloroquine	chloroquine	NNP
cord-332109-ont0tqpn	347	10	and	and	CC
cord-332109-ont0tqpn	347	11	hydroxychloroquine	hydroxychloroquine	NNP
cord-332109-ont0tqpn	347	12	[	[	-LRB-
cord-332109-ont0tqpn	347	13	193	193	CD
cord-332109-ont0tqpn	347	14	,	,	,
cord-332109-ont0tqpn	347	15	194	194	CD
cord-332109-ont0tqpn	347	16	]	]	-RRB-
cord-332109-ont0tqpn	347	17	are	be	VBP
cord-332109-ont0tqpn	347	18	extremely	extremely	RB
cord-332109-ont0tqpn	347	19	controversial	controversial	JJ
cord-332109-ont0tqpn	347	20	,	,	,
cord-332109-ont0tqpn	347	21	including	include	VBG
cord-332109-ont0tqpn	347	22	a	a	DT
cord-332109-ont0tqpn	347	23	retracted	retracted	JJ
cord-332109-ont0tqpn	347	24	study	study	NN
cord-332109-ont0tqpn	347	25	[	[	-LRB-
cord-332109-ont0tqpn	347	26	195	195	CD
cord-332109-ont0tqpn	347	27	]	]	-RRB-
cord-332109-ont0tqpn	347	28	and	and	CC
cord-332109-ont0tqpn	347	29	a	a	DT
cord-332109-ont0tqpn	347	30	terminated	terminate	VBN
cord-332109-ont0tqpn	347	31	solidarity	solidarity	NN
cord-332109-ont0tqpn	347	32	clinical	clinical	JJ
cord-332109-ont0tqpn	347	33	trial	trial	NN
cord-332109-ont0tqpn	347	34	by	by	IN
cord-332109-ont0tqpn	347	35	the	the	DT
cord-332109-ont0tqpn	347	36	WHO	WHO	NNP
cord-332109-ont0tqpn	347	37	[	[	-LRB-
cord-332109-ont0tqpn	347	38	196	196	CD
cord-332109-ont0tqpn	347	39	]	]	-RRB-
cord-332109-ont0tqpn	347	40	.	.	.
cord-332109-ont0tqpn	348	1	The	the	DT
cord-332109-ont0tqpn	348	2	U.S.	U.S.	NNP
cord-332109-ont0tqpn	348	3	Food	Food	NNP
cord-332109-ont0tqpn	348	4	and	and	CC
cord-332109-ont0tqpn	348	5	Drug	Drug	NNP
cord-332109-ont0tqpn	348	6	Administration	Administration	NNP
cord-332109-ont0tqpn	348	7	(	(	-LRB-
cord-332109-ont0tqpn	348	8	FDA	FDA	NNP
cord-332109-ont0tqpn	348	9	)	)	-RRB-
cord-332109-ont0tqpn	348	10	recently	recently	RB
cord-332109-ont0tqpn	348	11	revoked	revoke	VBD
cord-332109-ont0tqpn	348	12	its	-PRON-	PRP$
cord-332109-ont0tqpn	348	13	Emergency	Emergency	NNP
cord-332109-ont0tqpn	348	14	Use	Use	NNP
cord-332109-ont0tqpn	348	15	Authorization	Authorization	NNP
cord-332109-ont0tqpn	348	16	(	(	-LRB-
cord-332109-ont0tqpn	348	17	EUA	EUA	NNP
cord-332109-ont0tqpn	348	18	)	)	-RRB-
cord-332109-ont0tqpn	348	19	to	to	TO
cord-332109-ont0tqpn	348	20	treat	treat	VB
cord-332109-ont0tqpn	348	21	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	348	22	[	[	-LRB-
cord-332109-ont0tqpn	348	23	197	197	CD
cord-332109-ont0tqpn	348	24	]	]	-RRB-
cord-332109-ont0tqpn	348	25	.	.	.
cord-332109-ont0tqpn	349	1	Other	other	JJ
cord-332109-ont0tqpn	349	2	drugs	drug	NNS
cord-332109-ont0tqpn	349	3	include	include	VBP
cord-332109-ont0tqpn	349	4	the	the	DT
cord-332109-ont0tqpn	349	5	anti	anti	JJ
cord-332109-ont0tqpn	349	6	-	-	JJ
cord-332109-ont0tqpn	349	7	HIV	hiv	JJ
cord-332109-ont0tqpn	349	8	drugs	drug	NNS
cord-332109-ont0tqpn	349	9	lopinavir	lopinavir	NNP
cord-332109-ont0tqpn	349	10	-	-	HYPH
cord-332109-ont0tqpn	349	11	ritonavir	ritonavir	NNP
cord-332109-ont0tqpn	349	12	in	in	IN
cord-332109-ont0tqpn	349	13	combination	combination	NN
cord-332109-ont0tqpn	349	14	with	with	IN
cord-332109-ont0tqpn	349	15	ribavirin	ribavirin	NN
cord-332109-ont0tqpn	349	16	[	[	-LRB-
cord-332109-ont0tqpn	349	17	198	198	CD
cord-332109-ont0tqpn	349	18	]	]	-RRB-
cord-332109-ont0tqpn	349	19	[	[	-LRB-
cord-332109-ont0tqpn	349	20	199	199	CD
cord-332109-ont0tqpn	349	21	]	]	-RRB-
cord-332109-ont0tqpn	349	22	[	[	-LRB-
cord-332109-ont0tqpn	349	23	200	200	CD
cord-332109-ont0tqpn	349	24	]	]	-RRB-
cord-332109-ont0tqpn	349	25	,	,	,
cord-332109-ont0tqpn	349	26	tumor	tumor	NN
cord-332109-ont0tqpn	349	27	chemotherapy	chemotherapy	NN
cord-332109-ont0tqpn	349	28	drugs	drug	NNS
cord-332109-ont0tqpn	349	29	,	,	,
cord-332109-ont0tqpn	349	30	doxorubicin	doxorubicin	NN
cord-332109-ont0tqpn	349	31	and	and	CC
cord-332109-ont0tqpn	349	32	paclitaxel	paclitaxel	NN
cord-332109-ont0tqpn	349	33	[	[	-LRB-
cord-332109-ont0tqpn	349	34	201	201	CD
cord-332109-ont0tqpn	349	35	]	]	-RRB-
cord-332109-ont0tqpn	349	36	,	,	,
cord-332109-ont0tqpn	349	37	traditional	traditional	JJ
cord-332109-ont0tqpn	349	38	herbal	herbal	JJ
cord-332109-ont0tqpn	349	39	medicines	medicine	NNS
cord-332109-ont0tqpn	349	40	[	[	-LRB-
cord-332109-ont0tqpn	349	41	202	202	CD
cord-332109-ont0tqpn	349	42	]	]	-RRB-
cord-332109-ont0tqpn	349	43	,	,	,
cord-332109-ont0tqpn	349	44	broad	broad	JJ
cord-332109-ont0tqpn	349	45	spectrum	spectrum	JJ
cord-332109-ont0tqpn	349	46	antiviral	antiviral	JJ
cord-332109-ont0tqpn	349	47	drug	drug	NN
cord-332109-ont0tqpn	349	48	niclosamide	niclosamide	NNP
cord-332109-ont0tqpn	349	49	[	[	-LRB-
cord-332109-ont0tqpn	349	50	203	203	CD
cord-332109-ont0tqpn	349	51	]	]	-RRB-
cord-332109-ont0tqpn	349	52	,	,	,
cord-332109-ont0tqpn	349	53	Janus	Janus	NNP
cord-332109-ont0tqpn	349	54	-	-	HYPH
cord-332109-ont0tqpn	349	55	associated	associate	VBN
cord-332109-ont0tqpn	349	56	kinase	kinase	NN
cord-332109-ont0tqpn	349	57	(	(	-LRB-
cord-332109-ont0tqpn	349	58	JAK	JAK	NNP
cord-332109-ont0tqpn	349	59	)	)	-RRB-
cord-332109-ont0tqpn	349	60	1	1	CD
cord-332109-ont0tqpn	349	61	and	and	CC
cord-332109-ont0tqpn	349	62	2	2	CD
cord-332109-ont0tqpn	349	63	inhibitor	inhibitor	NN
cord-332109-ont0tqpn	349	64	,	,	,
cord-332109-ont0tqpn	349	65	ruxolitinib	ruxolitinib	JJ
cord-332109-ont0tqpn	349	66	[	[	-LRB-
cord-332109-ont0tqpn	349	67	204	204	CD
cord-332109-ont0tqpn	349	68	]	]	-RRB-
cord-332109-ont0tqpn	349	69	,	,	,
cord-332109-ont0tqpn	349	70	anti	anti	JJ
cord-332109-ont0tqpn	349	71	-	-	JJ
cord-332109-ont0tqpn	349	72	influenza	influenza	JJ
cord-332109-ont0tqpn	349	73	drug	drug	NN
cord-332109-ont0tqpn	349	74	favipiravir	favipiravir	NNS
cord-332109-ont0tqpn	349	75	[	[	-LRB-
cord-332109-ont0tqpn	349	76	205	205	CD
cord-332109-ont0tqpn	349	77	]	]	-RRB-
cord-332109-ont0tqpn	349	78	,	,	,
cord-332109-ont0tqpn	349	79	antiviral	antiviral	JJ
cord-332109-ont0tqpn	349	80	drug	drug	NN
cord-332109-ont0tqpn	349	81	remdesivir	remdesivir	NNP
cord-332109-ont0tqpn	349	82	[	[	-LRB-
cord-332109-ont0tqpn	349	83	206	206	CD
cord-332109-ont0tqpn	349	84	]	]	-RRB-
cord-332109-ont0tqpn	349	85	[	[	-LRB-
cord-332109-ont0tqpn	349	86	207	207	CD
cord-332109-ont0tqpn	349	87	]	]	-RRB-
cord-332109-ont0tqpn	349	88	[	[	-LRB-
cord-332109-ont0tqpn	349	89	208	208	CD
cord-332109-ont0tqpn	349	90	]	]	-RRB-
cord-332109-ont0tqpn	349	91	,	,	,
cord-332109-ont0tqpn	349	92	and	and	CC
cord-332109-ont0tqpn	349	93	most	most	RBS
cord-332109-ont0tqpn	349	94	recently	recently	RB
cord-332109-ont0tqpn	349	95	,	,	,
cord-332109-ont0tqpn	349	96	a	a	DT
cord-332109-ont0tqpn	349	97	commonly	commonly	RB
cord-332109-ont0tqpn	349	98	used	use	VBN
cord-332109-ont0tqpn	349	99	steroid	steroid	NN
cord-332109-ont0tqpn	349	100	,	,	,
cord-332109-ont0tqpn	349	101	dexamethasone	dexamethasone	NN
cord-332109-ont0tqpn	349	102	[	[	-LRB-
cord-332109-ont0tqpn	349	103	209	209	CD
cord-332109-ont0tqpn	349	104	]	]	-RRB-
cord-332109-ont0tqpn	349	105	.	.	.
cord-332109-ont0tqpn	350	1	Many	many	JJ
cord-332109-ont0tqpn	350	2	of	of	IN
cord-332109-ont0tqpn	350	3	these	these	DT
cord-332109-ont0tqpn	350	4	drugs	drug	NNS
cord-332109-ont0tqpn	350	5	primarily	primarily	RB
cord-332109-ont0tqpn	350	6	target	target	VBP
cord-332109-ont0tqpn	350	7	the	the	DT
cord-332109-ont0tqpn	350	8	RdRp	RdRp	NNP
cord-332109-ont0tqpn	350	9	(	(	-LRB-
cord-332109-ont0tqpn	350	10	NSP12	NSP12	NNP
cord-332109-ont0tqpn	350	11	)	)	-RRB-
cord-332109-ont0tqpn	350	12	or	or	CC
cord-332109-ont0tqpn	350	13	the	the	DT
cord-332109-ont0tqpn	350	14	main	main	JJ
cord-332109-ont0tqpn	350	15	protease	protease	NN
cord-332109-ont0tqpn	350	16	,	,	,
cord-332109-ont0tqpn	350	17	M	M	NNP
cord-332109-ont0tqpn	350	18	pro	pro	NN
cord-332109-ont0tqpn	350	19	.	.	.
cord-332109-ont0tqpn	351	1	A	a	DT
cord-332109-ont0tqpn	351	2	cryo	cryo	NN
cord-332109-ont0tqpn	351	3	-	-	HYPH
cord-332109-ont0tqpn	351	4	EM	em	NN
cord-332109-ont0tqpn	351	5	structure	structure	NN
cord-332109-ont0tqpn	351	6	of	of	IN
cord-332109-ont0tqpn	351	7	NSP12	nsp12	NN
cord-332109-ont0tqpn	351	8	in	in	IN
cord-332109-ont0tqpn	351	9	complex	complex	NN
cord-332109-ont0tqpn	351	10	with	with	IN
cord-332109-ont0tqpn	351	11	its	-PRON-	PRP$
cord-332109-ont0tqpn	351	12	cofactors	cofactor	NNS
cord-332109-ont0tqpn	351	13	NSP7	NSP7	NNP
cord-332109-ont0tqpn	351	14	and	and	CC
cord-332109-ont0tqpn	351	15	NSP8	NSP8	NNP
cord-332109-ont0tqpn	351	16	has	have	VBZ
cord-332109-ont0tqpn	351	17	been	be	VBN
cord-332109-ont0tqpn	351	18	reported	report	VBN
cord-332109-ont0tqpn	351	19	[	[	-LRB-
cord-332109-ont0tqpn	351	20	210	210	CD
cord-332109-ont0tqpn	351	21	]	]	-RRB-
cord-332109-ont0tqpn	351	22	.	.	.
cord-332109-ont0tqpn	352	1	Remdesivir	Remdesivir	NNP
cord-332109-ont0tqpn	352	2	,	,	,
cord-332109-ont0tqpn	352	3	the	the	DT
cord-332109-ont0tqpn	352	4	only	only	JJ
cord-332109-ont0tqpn	352	5	proven	prove	VBN
cord-332109-ont0tqpn	352	6	effective	effective	JJ
cord-332109-ont0tqpn	352	7	drug	drug	NN
cord-332109-ont0tqpn	352	8	against	against	IN
cord-332109-ont0tqpn	352	9	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	352	10	so	so	RB
cord-332109-ont0tqpn	352	11	far	far	RB
cord-332109-ont0tqpn	352	12	,	,	,
cord-332109-ont0tqpn	352	13	is	be	VBZ
cord-332109-ont0tqpn	352	14	found	find	VBN
cord-332109-ont0tqpn	352	15	to	to	TO
cord-332109-ont0tqpn	352	16	potently	potently	RB
cord-332109-ont0tqpn	352	17	inhibit	inhibit	VB
cord-332109-ont0tqpn	352	18	RdRp	RdRp	NNP
cord-332109-ont0tqpn	352	19	in	in	IN
cord-332109-ont0tqpn	352	20	MERS	MERS	NNP
cord-332109-ont0tqpn	352	21	-	-	HYPH
cord-332109-ont0tqpn	352	22	CoV	CoV	NNP
cord-332109-ont0tqpn	352	23	[	[	-LRB-
cord-332109-ont0tqpn	352	24	211	211	CD
cord-332109-ont0tqpn	352	25	]	]	-RRB-
cord-332109-ont0tqpn	352	26	and	and	CC
cord-332109-ont0tqpn	352	27	SARS	SARS	NNP
cord-332109-ont0tqpn	352	28	-	-	HYPH
cord-332109-ont0tqpn	352	29	CoV2	CoV2	NNP
cord-332109-ont0tqpn	352	30	[	[	-LRB-
cord-332109-ont0tqpn	352	31	212	212	CD
cord-332109-ont0tqpn	352	32	]	]	-RRB-
cord-332109-ont0tqpn	352	33	.	.	.
cord-332109-ont0tqpn	353	1	Ribavirin	Ribavirin	NNP
cord-332109-ont0tqpn	353	2	and	and	CC
cord-332109-ont0tqpn	353	3	Favipiravir	Favipiravir	NNP
cord-332109-ont0tqpn	353	4	also	also	RB
cord-332109-ont0tqpn	353	5	function	function	VBP
cord-332109-ont0tqpn	353	6	as	as	IN
cord-332109-ont0tqpn	353	7	RdRp	RdRp	NNP
cord-332109-ont0tqpn	353	8	inhibitors	inhibitor	NNS
cord-332109-ont0tqpn	353	9	.	.	.
cord-332109-ont0tqpn	354	1	The	the	DT
cord-332109-ont0tqpn	354	2	crystal	crystal	JJ
cord-332109-ont0tqpn	354	3	structure	structure	NN
cord-332109-ont0tqpn	354	4	of	of	IN
cord-332109-ont0tqpn	354	5	the	the	DT
cord-332109-ont0tqpn	354	6	M	M	NNP
cord-332109-ont0tqpn	354	7	pro	pro	FW
cord-332109-ont0tqpn	354	8	with	with	IN
cord-332109-ont0tqpn	354	9	its	-PRON-	PRP$
cord-332109-ont0tqpn	354	10	inhibitor	inhibitor	NN
cord-332109-ont0tqpn	354	11	has	have	VBZ
cord-332109-ont0tqpn	354	12	been	be	VBN
cord-332109-ont0tqpn	354	13	recently	recently	RB
cord-332109-ont0tqpn	354	14	solved	solve	VBN
cord-332109-ont0tqpn	354	15	and	and	CC
cord-332109-ont0tqpn	354	16	reported	report	VBD
cord-332109-ont0tqpn	354	17	[	[	-LRB-
cord-332109-ont0tqpn	354	18	213	213	CD
cord-332109-ont0tqpn	354	19	,	,	,
cord-332109-ont0tqpn	354	20	214	214	CD
cord-332109-ont0tqpn	354	21	]	]	-RRB-
cord-332109-ont0tqpn	354	22	.	.	.
cord-332109-ont0tqpn	355	1	Due	due	IN
cord-332109-ont0tqpn	355	2	to	to	IN
cord-332109-ont0tqpn	355	3	its	-PRON-	PRP$
cord-332109-ont0tqpn	355	4	importance	importance	NN
cord-332109-ont0tqpn	355	5	in	in	IN
cord-332109-ont0tqpn	355	6	viral	viral	JJ
cord-332109-ont0tqpn	355	7	production	production	NN
cord-332109-ont0tqpn	355	8	,	,	,
cord-332109-ont0tqpn	355	9	and	and	CC
cord-332109-ont0tqpn	355	10	the	the	DT
cord-332109-ont0tqpn	355	11	lack	lack	NN
cord-332109-ont0tqpn	355	12	of	of	IN
cord-332109-ont0tqpn	355	13	similar	similar	JJ
cord-332109-ont0tqpn	355	14	proteins	protein	NNS
cord-332109-ont0tqpn	355	15	in	in	IN
cord-332109-ont0tqpn	355	16	human	human	JJ
cord-332109-ont0tqpn	355	17	cells	cell	NNS
cord-332109-ont0tqpn	355	18	,	,	,
cord-332109-ont0tqpn	355	19	the	the	DT
cord-332109-ont0tqpn	355	20	M	M	NNP
cord-332109-ont0tqpn	355	21	pro	pro	NN
cord-332109-ont0tqpn	355	22	is	be	VBZ
cord-332109-ont0tqpn	355	23	considered	consider	VBN
cord-332109-ont0tqpn	355	24	an	an	DT
cord-332109-ont0tqpn	355	25	important	important	JJ
cord-332109-ont0tqpn	355	26	drug	drug	NN
cord-332109-ont0tqpn	355	27	target	target	NN
cord-332109-ont0tqpn	355	28	in	in	IN
cord-332109-ont0tqpn	355	29	treating	treat	VBG
cord-332109-ont0tqpn	355	30	COVID-19	covid-19	ADD
cord-332109-ont0tqpn	355	31	[	[	-LRB-
cord-332109-ont0tqpn	355	32	213	213	CD
cord-332109-ont0tqpn	355	33	,	,	,
cord-332109-ont0tqpn	355	34	215	215	CD
cord-332109-ont0tqpn	355	35	,	,	,
cord-332109-ont0tqpn	355	36	216	216	CD
cord-332109-ont0tqpn	355	37	]	]	-RRB-
cord-332109-ont0tqpn	355	38	.	.	.
cord-332109-ont0tqpn	356	1	Niclosamide	Niclosamide	NNP
cord-332109-ont0tqpn	356	2	and	and	CC
cord-332109-ont0tqpn	356	3	the	the	DT
cord-332109-ont0tqpn	356	4	anti	anti	JJ
cord-332109-ont0tqpn	356	5	-	-	JJ
cord-332109-ont0tqpn	356	6	HIV	hiv	JJ
cord-332109-ont0tqpn	356	7	combination	combination	NN
cord-332109-ont0tqpn	356	8	drug	drug	NN
cord-332109-ont0tqpn	356	9	lopinavir	lopinavir	NNS
cord-332109-ont0tqpn	356	10	-	-	HYPH
cord-332109-ont0tqpn	356	11	ritonavir	ritonavir	NNS
cord-332109-ont0tqpn	356	12	,	,	,
cord-332109-ont0tqpn	356	13	are	be	VBP
cord-332109-ont0tqpn	356	14	inhibitors	inhibitor	NNS
cord-332109-ont0tqpn	356	15	of	of	IN
cord-332109-ont0tqpn	356	16	the	the	DT
cord-332109-ont0tqpn	356	17	main	main	JJ
cord-332109-ont0tqpn	356	18	protease	protease	NN
cord-332109-ont0tqpn	356	19	.	.	.
cord-332109-ont0tqpn	357	1	Structure	structure	NN
cord-332109-ont0tqpn	357	2	-	-	HYPH
cord-332109-ont0tqpn	357	3	based	base	VBN
cord-332109-ont0tqpn	357	4	design	design	NN
cord-332109-ont0tqpn	357	5	has	have	VBZ
cord-332109-ont0tqpn	357	6	led	lead	VBN
cord-332109-ont0tqpn	357	7	to	to	IN
cord-332109-ont0tqpn	357	8	the	the	DT
cord-332109-ont0tqpn	357	9	development	development	NN
cord-332109-ont0tqpn	357	10	of	of	IN
cord-332109-ont0tqpn	357	11	new	new	JJ
cord-332109-ont0tqpn	357	12	inhibitors	inhibitor	NNS
cord-332109-ont0tqpn	357	13	of	of	IN
cord-332109-ont0tqpn	357	14	the	the	DT
cord-332109-ont0tqpn	357	15	M	M	NNP
cord-332109-ont0tqpn	357	16	pro	pro	FW
cord-332109-ont0tqpn	357	17	with	with	IN
cord-332109-ont0tqpn	357	18	desirable	desirable	JJ
cord-332109-ont0tqpn	357	19	pharmacokinetic	pharmacokinetic	JJ
cord-332109-ont0tqpn	357	20	properties	property	NNS
cord-332109-ont0tqpn	357	21	and	and	CC
cord-332109-ont0tqpn	357	22	low	low	JJ
cord-332109-ont0tqpn	357	23	toxicity	toxicity	NN
cord-332109-ont0tqpn	357	24	[	[	-LRB-
cord-332109-ont0tqpn	357	25	217	217	CD
cord-332109-ont0tqpn	357	26	]	]	-RRB-
cord-332109-ont0tqpn	357	27	.	.	.
cord-332109-ont0tqpn	358	1	The	the	DT
cord-332109-ont0tqpn	358	2	SARS	SARS	NNP
cord-332109-ont0tqpn	358	3	-	-	HYPH
cord-332109-ont0tqpn	358	4	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	358	5	entry	entry	NN
cord-332109-ont0tqpn	358	6	point	point	NN
cord-332109-ont0tqpn	358	7	,	,	,
cord-332109-ont0tqpn	358	8	ACE2	ACE2	NNP
cord-332109-ont0tqpn	358	9	,	,	,
cord-332109-ont0tqpn	358	10	and	and	CC
cord-332109-ont0tqpn	358	11	the	the	DT
cord-332109-ont0tqpn	358	12	associated	associate	VBN
cord-332109-ont0tqpn	358	13	protease	protease	NN
cord-332109-ont0tqpn	358	14	,	,	,
cord-332109-ont0tqpn	358	15	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	358	16	,	,	,
cord-332109-ont0tqpn	358	17	are	be	VBP
cord-332109-ont0tqpn	358	18	also	also	RB
cord-332109-ont0tqpn	358	19	considered	consider	VBN
cord-332109-ont0tqpn	358	20	potential	potential	JJ
cord-332109-ont0tqpn	358	21	drug	drug	NN
cord-332109-ont0tqpn	358	22	targets	target	NNS
cord-332109-ont0tqpn	358	23	[	[	-LRB-
cord-332109-ont0tqpn	358	24	28	28	CD
cord-332109-ont0tqpn	358	25	]	]	-RRB-
cord-332109-ont0tqpn	358	26	.	.	.
cord-332109-ont0tqpn	359	1	Tremendous	tremendous	JJ
cord-332109-ont0tqpn	359	2	research	research	NN
cord-332109-ont0tqpn	359	3	efforts	effort	NNS
cord-332109-ont0tqpn	359	4	have	have	VBP
cord-332109-ont0tqpn	359	5	been	be	VBN
cord-332109-ont0tqpn	359	6	put	put	VBN
cord-332109-ont0tqpn	359	7	into	into	IN
cord-332109-ont0tqpn	359	8	identifying	identify	VBG
cord-332109-ont0tqpn	359	9	,	,	,
cord-332109-ont0tqpn	359	10	isolating	isolate	VBG
cord-332109-ont0tqpn	359	11	,	,	,
cord-332109-ont0tqpn	359	12	and	and	CC
cord-332109-ont0tqpn	359	13	developing	develop	VBG
cord-332109-ont0tqpn	359	14	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	359	15	antibodies	antibody	NNS
cord-332109-ont0tqpn	359	16	against	against	IN
cord-332109-ont0tqpn	359	17	SARS	SARS	NNP
cord-332109-ont0tqpn	359	18	-	-	HYPH
cord-332109-ont0tqpn	359	19	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	359	20	.	.	.
cord-332109-ont0tqpn	360	1	The	the	DT
cord-332109-ont0tqpn	360	2	S	S	NNP
cord-332109-ont0tqpn	360	3	protein	protein	NN
cord-332109-ont0tqpn	360	4	,	,	,
cord-332109-ont0tqpn	360	5	which	which	WDT
cord-332109-ont0tqpn	360	6	plays	play	VBZ
cord-332109-ont0tqpn	360	7	a	a	DT
cord-332109-ont0tqpn	360	8	key	key	JJ
cord-332109-ont0tqpn	360	9	role	role	NN
cord-332109-ont0tqpn	360	10	in	in	IN
cord-332109-ont0tqpn	360	11	recognizing	recognize	VBG
cord-332109-ont0tqpn	360	12	and	and	CC
cord-332109-ont0tqpn	360	13	binding	bind	VBG
cord-332109-ont0tqpn	360	14	to	to	IN
cord-332109-ont0tqpn	360	15	the	the	DT
cord-332109-ont0tqpn	360	16	ACE2	ACE2	NNP
cord-332109-ont0tqpn	360	17	receptor	receptor	NN
cord-332109-ont0tqpn	360	18	to	to	TO
cord-332109-ont0tqpn	360	19	gain	gain	VB
cord-332109-ont0tqpn	360	20	entry	entry	NN
cord-332109-ont0tqpn	360	21	into	into	IN
cord-332109-ont0tqpn	360	22	the	the	DT
cord-332109-ont0tqpn	360	23	host	host	NN
cord-332109-ont0tqpn	360	24	cell	cell	NN
cord-332109-ont0tqpn	360	25	,	,	,
cord-332109-ont0tqpn	360	26	is	be	VBZ
cord-332109-ont0tqpn	360	27	the	the	DT
cord-332109-ont0tqpn	360	28	main	main	JJ
cord-332109-ont0tqpn	360	29	focus	focus	NN
cord-332109-ont0tqpn	360	30	for	for	IN
cord-332109-ont0tqpn	360	31	developing	develop	VBG
cord-332109-ont0tqpn	360	32	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	360	33	antibodies	antibody	NNS
cord-332109-ont0tqpn	360	34	and	and	CC
cord-332109-ont0tqpn	360	35	vaccines	vaccine	NNS
cord-332109-ont0tqpn	360	36	against	against	IN
cord-332109-ont0tqpn	360	37	SARS	SARS	NNP
cord-332109-ont0tqpn	360	38	-	-	HYPH
cord-332109-ont0tqpn	360	39	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	360	40	[	[	-LRB-
cord-332109-ont0tqpn	360	41	24	24	CD
cord-332109-ont0tqpn	360	42	,	,	,
cord-332109-ont0tqpn	360	43	25	25	CD
cord-332109-ont0tqpn	360	44	]	]	-RRB-
cord-332109-ont0tqpn	360	45	.	.	.
cord-332109-ont0tqpn	361	1	Neutralizing	neutralize	VBG
cord-332109-ont0tqpn	361	2	monoclonal	monoclonal	JJ
cord-332109-ont0tqpn	361	3	antibodies	antibody	NNS
cord-332109-ont0tqpn	361	4	isolated	isolate	VBN
cord-332109-ont0tqpn	361	5	from	from	IN
cord-332109-ont0tqpn	362	1	convalescent	convalescent	JJ
cord-332109-ont0tqpn	362	2	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	362	3	patients	patient	NNS
cord-332109-ont0tqpn	362	4	were	be	VBD
cord-332109-ont0tqpn	362	5	found	find	VBN
cord-332109-ont0tqpn	362	6	to	to	TO
cord-332109-ont0tqpn	362	7	block	block	VB
cord-332109-ont0tqpn	362	8	the	the	DT
cord-332109-ont0tqpn	362	9	RBD	RBD	NNP
cord-332109-ont0tqpn	362	10	surface	surface	NN
cord-332109-ont0tqpn	362	11	of	of	IN
cord-332109-ont0tqpn	362	12	the	the	DT
cord-332109-ont0tqpn	362	13	S	S	NNP
cord-332109-ont0tqpn	362	14	protein	protein	NN
cord-332109-ont0tqpn	362	15	from	from	IN
cord-332109-ont0tqpn	362	16	binding	bind	VBG
cord-332109-ont0tqpn	362	17	to	to	IN
cord-332109-ont0tqpn	362	18	ACE2	ACE2	NNP
cord-332109-ont0tqpn	362	19	,	,	,
cord-332109-ont0tqpn	362	20	and	and	CC
cord-332109-ont0tqpn	362	21	these	these	DT
cord-332109-ont0tqpn	362	22	antibodies	antibody	NNS
cord-332109-ont0tqpn	362	23	showed	show	VBD
cord-332109-ont0tqpn	362	24	effectiveness	effectiveness	NN
cord-332109-ont0tqpn	362	25	in	in	IN
cord-332109-ont0tqpn	362	26	reducing	reduce	VBG
cord-332109-ont0tqpn	362	27	viral	viral	JJ
cord-332109-ont0tqpn	362	28	infection	infection	NN
cord-332109-ont0tqpn	362	29	in	in	IN
cord-332109-ont0tqpn	362	30	animal	animal	NN
cord-332109-ont0tqpn	362	31	models	model	NNS
cord-332109-ont0tqpn	362	32	[	[	-LRB-
cord-332109-ont0tqpn	362	33	218	218	CD
cord-332109-ont0tqpn	362	34	]	]	-RRB-
cord-332109-ont0tqpn	362	35	[	[	-LRB-
cord-332109-ont0tqpn	362	36	219	219	CD
cord-332109-ont0tqpn	362	37	]	]	-RRB-
cord-332109-ont0tqpn	362	38	[	[	-LRB-
cord-332109-ont0tqpn	362	39	220	220	CD
cord-332109-ont0tqpn	362	40	]	]	-RRB-
cord-332109-ont0tqpn	362	41	.	.	.
cord-332109-ont0tqpn	363	1	The	the	DT
cord-332109-ont0tqpn	363	2	crystal	crystal	JJ
cord-332109-ont0tqpn	363	3	structure	structure	NN
cord-332109-ont0tqpn	363	4	of	of	IN
cord-332109-ont0tqpn	363	5	the	the	DT
cord-332109-ont0tqpn	363	6	RBD	RBD	NNP
cord-332109-ont0tqpn	363	7	-	-	HYPH
cord-332109-ont0tqpn	363	8	bound	bind	VBN
cord-332109-ont0tqpn	363	9	antibody	antibody	NN
cord-332109-ont0tqpn	363	10	provided	provide	VBD
cord-332109-ont0tqpn	363	11	a	a	DT
cord-332109-ont0tqpn	363	12	clear	clear	JJ
cord-332109-ont0tqpn	363	13	picture	picture	NN
cord-332109-ont0tqpn	363	14	on	on	IN
cord-332109-ont0tqpn	363	15	inhibition	inhibition	NN
cord-332109-ont0tqpn	363	16	of	of	IN
cord-332109-ont0tqpn	363	17	viral	viral	JJ
cord-332109-ont0tqpn	363	18	interaction	interaction	NN
cord-332109-ont0tqpn	363	19	with	with	IN
cord-332109-ont0tqpn	363	20	ACE2	ACE2	NNP
cord-332109-ont0tqpn	363	21	[	[	-LRB-
cord-332109-ont0tqpn	363	22	221	221	CD
cord-332109-ont0tqpn	363	23	]	]	-RRB-
cord-332109-ont0tqpn	363	24	.	.	.
cord-332109-ont0tqpn	364	1	The	the	DT
cord-332109-ont0tqpn	364	2	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	364	3	antibodies	antibody	NNS
cord-332109-ont0tqpn	364	4	isolated	isolate	VBN
cord-332109-ont0tqpn	364	5	from	from	IN
cord-332109-ont0tqpn	364	6	SARS	SARS	NNP
cord-332109-ont0tqpn	364	7	-	-	HYPH
cord-332109-ont0tqpn	364	8	CoV	CoV	NNP
cord-332109-ont0tqpn	364	9	patients	patient	NNS
cord-332109-ont0tqpn	364	10	seemed	seem	VBD
cord-332109-ont0tqpn	364	11	to	to	TO
cord-332109-ont0tqpn	364	12	cross	cross	VB
cord-332109-ont0tqpn	364	13	-	-	VB
cord-332109-ont0tqpn	364	14	neutralize	neutralize	VB
cord-332109-ont0tqpn	364	15	SARS	SARS	NNP
cord-332109-ont0tqpn	364	16	-	-	HYPH
cord-332109-ont0tqpn	364	17	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	364	18	[	[	-LRB-
cord-332109-ont0tqpn	364	19	222	222	CD
cord-332109-ont0tqpn	364	20	]	]	-RRB-
cord-332109-ont0tqpn	364	21	.	.	.
cord-332109-ont0tqpn	365	1	The	the	DT
cord-332109-ont0tqpn	365	2	RBD	RBD	NNP
cord-332109-ont0tqpn	365	3	is	be	VBZ
cord-332109-ont0tqpn	365	4	not	not	RB
cord-332109-ont0tqpn	365	5	the	the	DT
cord-332109-ont0tqpn	365	6	only	only	JJ
cord-332109-ont0tqpn	365	7	site	site	NN
cord-332109-ont0tqpn	365	8	that	that	IN
cord-332109-ont0tqpn	365	9	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	365	10	antibodies	antibody	NNS
cord-332109-ont0tqpn	365	11	may	may	MD
cord-332109-ont0tqpn	365	12	block	block	VB
cord-332109-ont0tqpn	365	13	.	.	.
cord-332109-ont0tqpn	366	1	A	a	DT
cord-332109-ont0tqpn	366	2	monoclonal	monoclonal	JJ
cord-332109-ont0tqpn	366	3	antibody	antibody	NN
cord-332109-ont0tqpn	366	4	isolated	isolate	VBN
cord-332109-ont0tqpn	366	5	from	from	IN
cord-332109-ont0tqpn	366	6	convalescent	convalescent	JJ
cord-332109-ont0tqpn	366	7	COVID-19	covid-19	CD
cord-332109-ont0tqpn	366	8	patients	patient	NNS
cord-332109-ont0tqpn	366	9	exhibits	exhibit	VBZ
cord-332109-ont0tqpn	366	10	high	high	JJ
cord-332109-ont0tqpn	366	11	neutralization	neutralization	NN
cord-332109-ont0tqpn	366	12	potency	potency	NN
cord-332109-ont0tqpn	366	13	against	against	IN
cord-332109-ont0tqpn	366	14	SARS	SARS	NNP
cord-332109-ont0tqpn	366	15	-	-	HYPH
cord-332109-ont0tqpn	366	16	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	366	17	.	.	.
cord-332109-ont0tqpn	367	1	This	this	DT
cord-332109-ont0tqpn	367	2	antibody	antibody	NN
cord-332109-ont0tqpn	367	3	does	do	VBZ
cord-332109-ont0tqpn	367	4	not	not	RB
cord-332109-ont0tqpn	367	5	bind	bind	VB
cord-332109-ont0tqpn	367	6	to	to	IN
cord-332109-ont0tqpn	367	7	the	the	DT
cord-332109-ont0tqpn	367	8	RBD	RBD	NNP
cord-332109-ont0tqpn	367	9	,	,	,
cord-332109-ont0tqpn	367	10	but	but	CC
cord-332109-ont0tqpn	367	11	it	-PRON-	PRP
cord-332109-ont0tqpn	367	12	tightly	tightly	RB
cord-332109-ont0tqpn	367	13	associates	associate	VBZ
cord-332109-ont0tqpn	367	14	with	with	IN
cord-332109-ont0tqpn	367	15	the	the	DT
cord-332109-ont0tqpn	367	16	N	n	CD
cord-332109-ont0tqpn	367	17	-	-	HYPH
cord-332109-ont0tqpn	367	18	terminal	terminal	NN
cord-332109-ont0tqpn	367	19	domain	domain	NN
cord-332109-ont0tqpn	367	20	of	of	IN
cord-332109-ont0tqpn	367	21	the	the	DT
cord-332109-ont0tqpn	367	22	S	S	NNP
cord-332109-ont0tqpn	367	23	protein	protein	NN
cord-332109-ont0tqpn	367	24	[	[	-LRB-
cord-332109-ont0tqpn	367	25	223	223	CD
cord-332109-ont0tqpn	367	26	]	]	-RRB-
cord-332109-ont0tqpn	367	27	.	.	.
cord-332109-ont0tqpn	368	1	A	a	DT
cord-332109-ont0tqpn	368	2	recombinant	recombinant	JJ
cord-332109-ont0tqpn	368	3	antibody	antibody	NN
cord-332109-ont0tqpn	368	4	fused	fuse	VBN
cord-332109-ont0tqpn	368	5	with	with	IN
cord-332109-ont0tqpn	368	6	the	the	DT
cord-332109-ont0tqpn	368	7	human	human	JJ
cord-332109-ont0tqpn	368	8	ACE2	ACE2	NNP
cord-332109-ont0tqpn	368	9	extracellular	extracellular	JJ
cord-332109-ont0tqpn	368	10	domain	domain	NN
cord-332109-ont0tqpn	368	11	displayed	display	VBD
cord-332109-ont0tqpn	368	12	desired	desire	VBN
cord-332109-ont0tqpn	368	13	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	368	14	properties	property	NNS
cord-332109-ont0tqpn	368	15	in	in	IN
cord-332109-ont0tqpn	368	16	vivo	vivo	NN
cord-332109-ont0tqpn	368	17	and	and	CC
cord-332109-ont0tqpn	368	18	in	in	IN
cord-332109-ont0tqpn	368	19	mice	mouse	NNS
cord-332109-ont0tqpn	368	20	[	[	-LRB-
cord-332109-ont0tqpn	368	21	224	224	CD
cord-332109-ont0tqpn	368	22	]	]	-RRB-
cord-332109-ont0tqpn	368	23	.	.	.
cord-332109-ont0tqpn	369	1	Single	single	JJ
cord-332109-ont0tqpn	369	2	-	-	HYPH
cord-332109-ont0tqpn	369	3	domain	domain	NN
cord-332109-ont0tqpn	369	4	camelid	camelid	NN
cord-332109-ont0tqpn	369	5	antibodies	antibody	NNS
cord-332109-ont0tqpn	369	6	from	from	IN
cord-332109-ont0tqpn	369	7	a	a	DT
cord-332109-ont0tqpn	369	8	llama	llama	NN
cord-332109-ont0tqpn	369	9	were	be	VBD
cord-332109-ont0tqpn	369	10	found	find	VBN
cord-332109-ont0tqpn	369	11	to	to	TO
cord-332109-ont0tqpn	369	12	cross	cross	VB
cord-332109-ont0tqpn	369	13	-	-	VB
cord-332109-ont0tqpn	369	14	react	react	VB
cord-332109-ont0tqpn	369	15	and	and	CC
cord-332109-ont0tqpn	369	16	neutralize	neutralize	VB
cord-332109-ont0tqpn	369	17	MERS	MERS	NNP
cord-332109-ont0tqpn	369	18	-	-	HYPH
cord-332109-ont0tqpn	369	19	CoV	CoV	NNP
cord-332109-ont0tqpn	369	20	,	,	,
cord-332109-ont0tqpn	369	21	SARS	SARS	NNP
cord-332109-ont0tqpn	369	22	-	-	HYPH
cord-332109-ont0tqpn	369	23	CoV	CoV	NNP
cord-332109-ont0tqpn	369	24	,	,	,
cord-332109-ont0tqpn	369	25	and	and	CC
cord-332109-ont0tqpn	369	26	SARS	SARS	NNP
cord-332109-ont0tqpn	369	27	-	-	HYPH
cord-332109-ont0tqpn	369	28	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	369	29	S	S	NNP
cord-332109-ont0tqpn	370	1	pseudotyped	pseudotyped	NNP
cord-332109-ont0tqpn	370	2	viruses	virus	NNS
cord-332109-ont0tqpn	370	3	[	[	-LRB-
cord-332109-ont0tqpn	370	4	225	225	CD
cord-332109-ont0tqpn	370	5	]	]	-RRB-
cord-332109-ont0tqpn	370	6	.	.	.
cord-332109-ont0tqpn	371	1	Cocktails	cocktail	NNS
cord-332109-ont0tqpn	371	2	of	of	IN
cord-332109-ont0tqpn	371	3	antibodies	antibody	NNS
cord-332109-ont0tqpn	371	4	that	that	WDT
cord-332109-ont0tqpn	371	5	simultaneously	simultaneously	RB
cord-332109-ont0tqpn	371	6	bind	bind	VBP
cord-332109-ont0tqpn	371	7	to	to	IN
cord-332109-ont0tqpn	371	8	different	different	JJ
cord-332109-ont0tqpn	371	9	epitopes	epitope	NNS
cord-332109-ont0tqpn	371	10	of	of	IN
cord-332109-ont0tqpn	371	11	the	the	DT
cord-332109-ont0tqpn	371	12	RBD	RBD	NNP
cord-332109-ont0tqpn	371	13	may	may	MD
cord-332109-ont0tqpn	371	14	provide	provide	VB
cord-332109-ont0tqpn	371	15	more	more	RBR
cord-332109-ont0tqpn	371	16	potent	potent	JJ
cord-332109-ont0tqpn	371	17	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	371	18	power	power	NN
cord-332109-ont0tqpn	371	19	and	and	CC
cord-332109-ont0tqpn	371	20	significantly	significantly	RB
cord-332109-ont0tqpn	371	21	reduce	reduce	VB
cord-332109-ont0tqpn	371	22	virus	virus	NN
cord-332109-ont0tqpn	371	23	escaping	escape	VBG
cord-332109-ont0tqpn	371	24	through	through	IN
cord-332109-ont0tqpn	371	25	mutations	mutation	NNS
cord-332109-ont0tqpn	371	26	[	[	-LRB-
cord-332109-ont0tqpn	371	27	226	226	CD
cord-332109-ont0tqpn	371	28	]	]	-RRB-
cord-332109-ont0tqpn	371	29	[	[	-LRB-
cord-332109-ont0tqpn	371	30	227	227	CD
cord-332109-ont0tqpn	371	31	]	]	-RRB-
cord-332109-ont0tqpn	371	32	[	[	-LRB-
cord-332109-ont0tqpn	371	33	228	228	CD
cord-332109-ont0tqpn	371	34	]	]	-RRB-
cord-332109-ont0tqpn	371	35	.	.	.
cord-332109-ont0tqpn	372	1	Vaccines	vaccine	NNS
cord-332109-ont0tqpn	372	2	are	be	VBP
cord-332109-ont0tqpn	372	3	crucial	crucial	JJ
cord-332109-ont0tqpn	372	4	in	in	IN
cord-332109-ont0tqpn	372	5	combating	combat	VBG
cord-332109-ont0tqpn	372	6	the	the	DT
cord-332109-ont0tqpn	372	7	COVID-19	covid-19	CD
cord-332109-ont0tqpn	372	8	pandemic	pandemic	NN
cord-332109-ont0tqpn	372	9	.	.	.
cord-332109-ont0tqpn	373	1	The	the	DT
cord-332109-ont0tqpn	373	2	RBD	RBD	NNP
cord-332109-ont0tqpn	373	3	of	of	IN
cord-332109-ont0tqpn	373	4	the	the	DT
cord-332109-ont0tqpn	373	5	S	S	NNP
cord-332109-ont0tqpn	373	6	protein	protein	NN
cord-332109-ont0tqpn	373	7	is	be	VBZ
cord-332109-ont0tqpn	373	8	,	,	,
cord-332109-ont0tqpn	373	9	again	again	RB
cord-332109-ont0tqpn	373	10	,	,	,
cord-332109-ont0tqpn	373	11	the	the	DT
cord-332109-ont0tqpn	373	12	main	main	JJ
cord-332109-ont0tqpn	373	13	target	target	NN
cord-332109-ont0tqpn	373	14	for	for	IN
cord-332109-ont0tqpn	373	15	vaccine	vaccine	NN
cord-332109-ont0tqpn	373	16	development	development	NN
cord-332109-ont0tqpn	373	17	[	[	-LRB-
cord-332109-ont0tqpn	373	18	229	229	CD
cord-332109-ont0tqpn	373	19	]	]	-RRB-
cord-332109-ont0tqpn	373	20	.	.	.
cord-332109-ont0tqpn	374	1	According	accord	VBG
cord-332109-ont0tqpn	374	2	to	to	IN
cord-332109-ont0tqpn	374	3	WHO	who	WP
cord-332109-ont0tqpn	374	4	"	"	``
cord-332109-ont0tqpn	374	5	Draft	draft	NN
cord-332109-ont0tqpn	374	6	landscape	landscape	NN
cord-332109-ont0tqpn	374	7	of	of	IN
cord-332109-ont0tqpn	374	8	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	374	9	candidate	candidate	NN
cord-332109-ont0tqpn	374	10	vaccines	vaccine	NNS
cord-332109-ont0tqpn	374	11	"	"	''
cord-332109-ont0tqpn	374	12	,	,	,
cord-332109-ont0tqpn	374	13	there	there	EX
cord-332109-ont0tqpn	374	14	are	be	VBP
cord-332109-ont0tqpn	374	15	13	13	CD
cord-332109-ont0tqpn	374	16	candidates	candidate	NNS
cord-332109-ont0tqpn	374	17	currently	currently	RB
cord-332109-ont0tqpn	374	18	in	in	IN
cord-332109-ont0tqpn	374	19	clinical	clinical	JJ
cord-332109-ont0tqpn	374	20	trials	trial	NNS
cord-332109-ont0tqpn	374	21	,	,	,
cord-332109-ont0tqpn	374	22	and	and	CC
cord-332109-ont0tqpn	374	23	128	128	CD
cord-332109-ont0tqpn	374	24	candidates	candidate	NNS
cord-332109-ont0tqpn	374	25	in	in	IN
cord-332109-ont0tqpn	374	26	preclinical	preclinical	JJ
cord-332109-ont0tqpn	374	27	stage	stage	NN
cord-332109-ont0tqpn	374	28	[	[	-LRB-
cord-332109-ont0tqpn	374	29	230	230	CD
cord-332109-ont0tqpn	374	30	]	]	-RRB-
cord-332109-ont0tqpn	374	31	.	.	.
cord-332109-ont0tqpn	375	1	These	these	DT
cord-332109-ont0tqpn	375	2	vaccine	vaccine	NN
cord-332109-ont0tqpn	375	3	candidates	candidate	NNS
cord-332109-ont0tqpn	375	4	cover	cover	VBP
cord-332109-ont0tqpn	375	5	almost	almost	RB
cord-332109-ont0tqpn	375	6	all	all	DT
cord-332109-ont0tqpn	375	7	technology	technology	NN
cord-332109-ont0tqpn	375	8	platforms	platform	NNS
cord-332109-ont0tqpn	375	9	,	,	,
cord-332109-ont0tqpn	375	10	including	include	VBG
cord-332109-ont0tqpn	375	11	more	more	JJR
cord-332109-ont0tqpn	375	12	traditional	traditional	JJ
cord-332109-ont0tqpn	375	13	non	non	NN
cord-332109-ont0tqpn	375	14	-	-	JJ
cord-332109-ont0tqpn	375	15	replicating	replicating	JJ
cord-332109-ont0tqpn	375	16	or	or	CC
cord-332109-ont0tqpn	375	17	replicating	replicate	VBG
cord-332109-ont0tqpn	375	18	viral	viral	JJ
cord-332109-ont0tqpn	375	19	vector	vector	NN
cord-332109-ont0tqpn	375	20	,	,	,
cord-332109-ont0tqpn	375	21	inactivated	inactivate	VBN
cord-332109-ont0tqpn	375	22	or	or	CC
cord-332109-ont0tqpn	375	23	live	live	JJ
cord-332109-ont0tqpn	375	24	attenuated	attenuated	JJ
cord-332109-ont0tqpn	375	25	virus	virus	NN
cord-332109-ont0tqpn	375	26	,	,	,
cord-332109-ont0tqpn	375	27	recombinant	recombinant	JJ
cord-332109-ont0tqpn	375	28	protein	protein	NN
cord-332109-ont0tqpn	375	29	subunit	subunit	NN
cord-332109-ont0tqpn	375	30	,	,	,
cord-332109-ont0tqpn	375	31	to	to	IN
cord-332109-ont0tqpn	375	32	more	more	RBR
cord-332109-ont0tqpn	375	33	recently	recently	RB
cord-332109-ont0tqpn	375	34	developed	develop	VBN
cord-332109-ont0tqpn	375	35	nucleic	nucleic	JJ
cord-332109-ont0tqpn	375	36	acid	acid	NN
cord-332109-ont0tqpn	375	37	(	(	-LRB-
cord-332109-ont0tqpn	375	38	DNA	DNA	NNP
cord-332109-ont0tqpn	375	39	or	or	CC
cord-332109-ont0tqpn	375	40	RNA	RNA	NNP
cord-332109-ont0tqpn	375	41	)	)	-RRB-
cord-332109-ont0tqpn	375	42	,	,	,
cord-332109-ont0tqpn	375	43	peptide	peptide	NN
cord-332109-ont0tqpn	375	44	,	,	,
cord-332109-ont0tqpn	375	45	and	and	CC
cord-332109-ont0tqpn	375	46	viral	viral	JJ
cord-332109-ont0tqpn	375	47	-	-	HYPH
cord-332109-ont0tqpn	375	48	like	like	JJ
cord-332109-ont0tqpn	375	49	particle	particle	NN
cord-332109-ont0tqpn	375	50	[	[	-LRB-
cord-332109-ont0tqpn	375	51	231	231	CD
cord-332109-ont0tqpn	375	52	]	]	-RRB-
cord-332109-ont0tqpn	375	53	.	.	.
cord-332109-ont0tqpn	376	1	There	there	EX
cord-332109-ont0tqpn	376	2	have	have	VBP
cord-332109-ont0tqpn	376	3	been	be	VBN
cord-332109-ont0tqpn	376	4	some	some	DT
cord-332109-ont0tqpn	376	5	encouraging	encouraging	JJ
cord-332109-ont0tqpn	376	6	results	result	NNS
cord-332109-ont0tqpn	376	7	from	from	IN
cord-332109-ont0tqpn	376	8	clinical	clinical	JJ
cord-332109-ont0tqpn	376	9	trials	trial	NNS
cord-332109-ont0tqpn	376	10	,	,	,
cord-332109-ont0tqpn	376	11	including	include	VBG
cord-332109-ont0tqpn	376	12	the	the	DT
cord-332109-ont0tqpn	376	13	first	first	JJ
cord-332109-ont0tqpn	376	14	mRNA	mRNA	NNP
cord-332109-ont0tqpn	376	15	vaccine	vaccine	NN
cord-332109-ont0tqpn	376	16	,	,	,
cord-332109-ont0tqpn	376	17	mRNA-1273	mrna-1273	XX
cord-332109-ont0tqpn	376	18	[	[	-LRB-
cord-332109-ont0tqpn	376	19	232	232	CD
cord-332109-ont0tqpn	376	20	,	,	,
cord-332109-ont0tqpn	376	21	233	233	CD
cord-332109-ont0tqpn	376	22	]	]	-RRB-
cord-332109-ont0tqpn	376	23	,	,	,
cord-332109-ont0tqpn	376	24	and	and	CC
cord-332109-ont0tqpn	376	25	an	an	DT
cord-332109-ont0tqpn	376	26	adenovirus	adenovirus	NN
cord-332109-ont0tqpn	376	27	type-5	type-5	IN
cord-332109-ont0tqpn	376	28	(	(	-LRB-
cord-332109-ont0tqpn	376	29	Ad-5	Ad-5	NNP
cord-332109-ont0tqpn	376	30	)	)	-RRB-
cord-332109-ont0tqpn	377	1	vectored	vectore	VBN
cord-332109-ont0tqpn	377	2	vaccine	vaccine	NN
cord-332109-ont0tqpn	377	3	[	[	-LRB-
cord-332109-ont0tqpn	377	4	234	234	CD
cord-332109-ont0tqpn	377	5	]	]	-RRB-
cord-332109-ont0tqpn	377	6	.	.	.
cord-332109-ont0tqpn	378	1	With	with	IN
cord-332109-ont0tqpn	378	2	the	the	DT
cord-332109-ont0tqpn	378	3	race	race	NN
cord-332109-ont0tqpn	378	4	to	to	IN
cord-332109-ont0tqpn	378	5	therapeutics	therapeutic	NNS
cord-332109-ont0tqpn	378	6	and	and	CC
cord-332109-ont0tqpn	378	7	vaccines	vaccine	NNS
cord-332109-ont0tqpn	378	8	towards	towards	IN
cord-332109-ont0tqpn	378	9	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	378	10	,	,	,
cord-332109-ont0tqpn	378	11	rarely	rarely	RB
cord-332109-ont0tqpn	378	12	have	have	VBP
cord-332109-ont0tqpn	378	13	the	the	DT
cord-332109-ont0tqpn	378	14	efforts	effort	NNS
cord-332109-ont0tqpn	378	15	specifically	specifically	RB
cord-332109-ont0tqpn	378	16	been	be	VBN
cord-332109-ont0tqpn	378	17	directed	direct	VBN
cord-332109-ont0tqpn	378	18	at	at	IN
cord-332109-ont0tqpn	378	19	SUD	SUD	NNP
cord-332109-ont0tqpn	378	20	complications	complication	NNS
cord-332109-ont0tqpn	378	21	in	in	IN
cord-332109-ont0tqpn	378	22	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	378	23	.	.	.
cord-332109-ont0tqpn	379	1	As	as	IN
cord-332109-ont0tqpn	379	2	we	-PRON-	PRP
cord-332109-ont0tqpn	379	3	analyzed	analyze	VBD
cord-332109-ont0tqpn	379	4	earlier	early	RBR
cord-332109-ont0tqpn	379	5	,	,	,
cord-332109-ont0tqpn	379	6	SUDs	sud	NNS
cord-332109-ont0tqpn	379	7	complicate	complicate	VBP
cord-332109-ont0tqpn	379	8	and	and	CC
cord-332109-ont0tqpn	379	9	impair	impair	VB
cord-332109-ont0tqpn	379	10	the	the	DT
cord-332109-ont0tqpn	379	11	respiratory	respiratory	JJ
cord-332109-ont0tqpn	379	12	system	system	NN
cord-332109-ont0tqpn	379	13	directly	directly	RB
cord-332109-ont0tqpn	379	14	,	,	,
cord-332109-ont0tqpn	379	15	and	and	CC
cord-332109-ont0tqpn	379	16	can	can	MD
cord-332109-ont0tqpn	379	17	intensify	intensify	VB
cord-332109-ont0tqpn	379	18	the	the	DT
cord-332109-ont0tqpn	379	19	severity	severity	NN
cord-332109-ont0tqpn	379	20	of	of	IN
cord-332109-ont0tqpn	379	21	the	the	DT
cord-332109-ont0tqpn	379	22	disease	disease	NN
cord-332109-ont0tqpn	379	23	through	through	IN
cord-332109-ont0tqpn	379	24	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	379	25	damage	damage	NN
cord-332109-ont0tqpn	379	26	and	and	CC
cord-332109-ont0tqpn	379	27	immune	immune	JJ
cord-332109-ont0tqpn	379	28	abnormality	abnormality	NN
cord-332109-ont0tqpn	379	29	.	.	.
cord-332109-ont0tqpn	380	1	There	there	EX
cord-332109-ont0tqpn	380	2	are	be	VBP
cord-332109-ont0tqpn	380	3	increasing	increase	VBG
cord-332109-ont0tqpn	380	4	concerns	concern	NNS
cord-332109-ont0tqpn	380	5	on	on	IN
cord-332109-ont0tqpn	380	6	capillary	capillary	JJ
cord-332109-ont0tqpn	380	7	endothelial	endothelial	JJ
cord-332109-ont0tqpn	380	8	damage	damage	NN
cord-332109-ont0tqpn	380	9	or	or	CC
cord-332109-ont0tqpn	380	10	endotheliitis	endotheliitis	NN
cord-332109-ont0tqpn	380	11	by	by	IN
cord-332109-ont0tqpn	380	12	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	380	13	and	and	CC
cord-332109-ont0tqpn	380	14	SUDs	sud	NNS
cord-332109-ont0tqpn	380	15	,	,	,
cord-332109-ont0tqpn	380	16	including	include	VBG
cord-332109-ont0tqpn	380	17	the	the	DT
cord-332109-ont0tqpn	380	18	harmful	harmful	JJ
cord-332109-ont0tqpn	380	19	effects	effect	NNS
cord-332109-ont0tqpn	380	20	on	on	IN
cord-332109-ont0tqpn	380	21	the	the	DT
cord-332109-ont0tqpn	380	22	BBB	BBB	NNP
cord-332109-ont0tqpn	380	23	integrity	integrity	NN
cord-332109-ont0tqpn	380	24	.	.	.
cord-332109-ont0tqpn	381	1	If	if	IN
cord-332109-ont0tqpn	381	2	the	the	DT
cord-332109-ont0tqpn	381	3	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	381	4	is	be	VBZ
cord-332109-ont0tqpn	381	5	allowed	allow	VBN
cord-332109-ont0tqpn	381	6	to	to	TO
cord-332109-ont0tqpn	381	7	migrate	migrate	VB
cord-332109-ont0tqpn	381	8	across	across	IN
cord-332109-ont0tqpn	381	9	the	the	DT
cord-332109-ont0tqpn	381	10	BBB	BBB	NNP
cord-332109-ont0tqpn	381	11	and	and	CC
cord-332109-ont0tqpn	381	12	to	to	TO
cord-332109-ont0tqpn	381	13	infect	infect	VB
cord-332109-ont0tqpn	381	14	the	the	DT
cord-332109-ont0tqpn	381	15	brain	brain	NN
cord-332109-ont0tqpn	381	16	,	,	,
cord-332109-ont0tqpn	381	17	long	long	JJ
cord-332109-ont0tqpn	381	18	-	-	HYPH
cord-332109-ont0tqpn	381	19	term	term	NN
cord-332109-ont0tqpn	381	20	neurological	neurological	JJ
cord-332109-ont0tqpn	381	21	degeneracy	degeneracy	NN
cord-332109-ont0tqpn	381	22	is	be	VBZ
cord-332109-ont0tqpn	381	23	expected	expect	VBN
cord-332109-ont0tqpn	381	24	,	,	,
cord-332109-ont0tqpn	381	25	and	and	CC
cord-332109-ont0tqpn	381	26	the	the	DT
cord-332109-ont0tqpn	381	27	treatment	treatment	NN
cord-332109-ont0tqpn	381	28	will	will	MD
cord-332109-ont0tqpn	381	29	be	be	VB
cord-332109-ont0tqpn	381	30	deemed	deem	VBN
cord-332109-ont0tqpn	381	31	challenging	challenging	JJ
cord-332109-ont0tqpn	381	32	.	.	.
cord-332109-ont0tqpn	382	1	SUDs	sud	NNS
cord-332109-ont0tqpn	382	2	can	can	MD
cord-332109-ont0tqpn	382	3	weaken	weaken	VB
cord-332109-ont0tqpn	382	4	the	the	DT
cord-332109-ont0tqpn	382	5	immune	immune	JJ
cord-332109-ont0tqpn	382	6	system	system	NN
cord-332109-ont0tqpn	382	7	,	,	,
cord-332109-ont0tqpn	382	8	alter	alter	VB
cord-332109-ont0tqpn	382	9	and	and	CC
cord-332109-ont0tqpn	382	10	disrupt	disrupt	VB
cord-332109-ont0tqpn	382	11	the	the	DT
cord-332109-ont0tqpn	382	12	HPA	HPA	NNP
cord-332109-ont0tqpn	382	13	axis	axis	NN
cord-332109-ont0tqpn	382	14	,	,	,
cord-332109-ont0tqpn	382	15	and	and	CC
cord-332109-ont0tqpn	382	16	stimulate	stimulate	VB
cord-332109-ont0tqpn	382	17	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	382	18	with	with	IN
cord-332109-ont0tqpn	382	19	heightened	heightened	JJ
cord-332109-ont0tqpn	382	20	expression	expression	NN
cord-332109-ont0tqpn	382	21	of	of	IN
cord-332109-ont0tqpn	382	22	TNFα	TNFα	NNS
cord-332109-ont0tqpn	382	23	,	,	,
cord-332109-ont0tqpn	382	24	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	382	25	,	,	,
cord-332109-ont0tqpn	382	26	and	and	CC
cord-332109-ont0tqpn	382	27	IL-6	IL-6	NNP
cord-332109-ont0tqpn	382	28	in	in	IN
cord-332109-ont0tqpn	382	29	the	the	DT
cord-332109-ont0tqpn	382	30	CNS	CNS	NNP
cord-332109-ont0tqpn	382	31	.	.	.
cord-332109-ont0tqpn	383	1	Anti	anti	JJ
cord-332109-ont0tqpn	383	2	-	-	JJ
cord-332109-ont0tqpn	383	3	TNFα	tnfα	JJ
cord-332109-ont0tqpn	383	4	therapy	therapy	NN
cord-332109-ont0tqpn	383	5	has	have	VBZ
cord-332109-ont0tqpn	383	6	been	be	VBN
cord-332109-ont0tqpn	383	7	used	use	VBN
cord-332109-ont0tqpn	383	8	in	in	IN
cord-332109-ont0tqpn	383	9	severe	severe	JJ
cord-332109-ont0tqpn	383	10	cases	case	NNS
cord-332109-ont0tqpn	383	11	of	of	IN
cord-332109-ont0tqpn	383	12	autoimmune	autoimmune	JJ
cord-332109-ont0tqpn	383	13	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	383	14	disease	disease	NN
cord-332109-ont0tqpn	383	15	to	to	TO
cord-332109-ont0tqpn	383	16	control	control	VB
cord-332109-ont0tqpn	383	17	inflammation	inflammation	NN
cord-332109-ont0tqpn	383	18	by	by	IN
cord-332109-ont0tqpn	383	19	downregulating	downregulate	VBG
cord-332109-ont0tqpn	384	1	IL-6	IL-6	NNP
cord-332109-ont0tqpn	384	2	and	and	CC
cord-332109-ont0tqpn	384	3	IL-1β	IL-1β	NNP
cord-332109-ont0tqpn	384	4	[	[	-LRB-
cord-332109-ont0tqpn	384	5	235	235	CD
cord-332109-ont0tqpn	384	6	]	]	-RRB-
cord-332109-ont0tqpn	384	7	.	.	.
cord-332109-ont0tqpn	385	1	Anti	Anti	NNP
cord-332109-ont0tqpn	385	2	-	-	NNP
cord-332109-ont0tqpn	385	3	IL-6	il-6	JJ
cord-332109-ont0tqpn	385	4	antibody	antibody	NN
cord-332109-ont0tqpn	385	5	may	may	MD
cord-332109-ont0tqpn	385	6	also	also	RB
cord-332109-ont0tqpn	385	7	be	be	VB
cord-332109-ont0tqpn	385	8	beneficial	beneficial	JJ
cord-332109-ont0tqpn	385	9	in	in	IN
cord-332109-ont0tqpn	385	10	inflammation	inflammation	NN
cord-332109-ont0tqpn	385	11	control	control	NN
cord-332109-ont0tqpn	385	12	[	[	-LRB-
cord-332109-ont0tqpn	385	13	236	236	CD
cord-332109-ont0tqpn	385	14	]	]	-RRB-
cord-332109-ont0tqpn	385	15	.	.	.
cord-332109-ont0tqpn	386	1	These	these	DT
cord-332109-ont0tqpn	386	2	treatments	treatment	NNS
cord-332109-ont0tqpn	386	3	could	could	MD
cord-332109-ont0tqpn	386	4	be	be	VB
cord-332109-ont0tqpn	386	5	helpful	helpful	JJ
cord-332109-ont0tqpn	386	6	for	for	IN
cord-332109-ont0tqpn	386	7	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	386	8	patients	patient	NNS
cord-332109-ont0tqpn	386	9	with	with	IN
cord-332109-ont0tqpn	386	10	SUDs	sud	NNS
cord-332109-ont0tqpn	386	11	.	.	.
cord-332109-ont0tqpn	387	1	Current	current	JJ
cord-332109-ont0tqpn	387	2	antiviral	antiviral	JJ
cord-332109-ont0tqpn	387	3	drugs	drug	NNS
cord-332109-ont0tqpn	387	4	are	be	VBP
cord-332109-ont0tqpn	387	5	designed	design	VBN
cord-332109-ont0tqpn	387	6	to	to	TO
cord-332109-ont0tqpn	387	7	interfere	interfere	VB
cord-332109-ont0tqpn	387	8	with	with	IN
cord-332109-ont0tqpn	387	9	viral	viral	JJ
cord-332109-ont0tqpn	387	10	replication	replication	NN
cord-332109-ont0tqpn	387	11	or	or	CC
cord-332109-ont0tqpn	387	12	viral	viral	JJ
cord-332109-ont0tqpn	387	13	protein	protein	NN
cord-332109-ont0tqpn	387	14	processing	processing	NN
cord-332109-ont0tqpn	387	15	.	.	.
cord-332109-ont0tqpn	388	1	For	for	IN
cord-332109-ont0tqpn	388	2	example	example	NN
cord-332109-ont0tqpn	388	3	,	,	,
cord-332109-ont0tqpn	388	4	the	the	DT
cord-332109-ont0tqpn	388	5	most	most	RBS
cord-332109-ont0tqpn	388	6	effective	effective	JJ
cord-332109-ont0tqpn	388	7	drug	drug	NN
cord-332109-ont0tqpn	388	8	,	,	,
cord-332109-ont0tqpn	388	9	remdesivir	remdesivir	NNP
cord-332109-ont0tqpn	388	10	,	,	,
cord-332109-ont0tqpn	388	11	which	which	WDT
cord-332109-ont0tqpn	388	12	can	can	MD
cord-332109-ont0tqpn	388	13	shorten	shorten	VB
cord-332109-ont0tqpn	388	14	the	the	DT
cord-332109-ont0tqpn	388	15	recovery	recovery	NN
cord-332109-ont0tqpn	388	16	time	time	NN
cord-332109-ont0tqpn	388	17	by	by	IN
cord-332109-ont0tqpn	388	18	30	30	CD
cord-332109-ont0tqpn	388	19	%	%	NN
cord-332109-ont0tqpn	388	20	[	[	-LRB-
cord-332109-ont0tqpn	388	21	206	206	CD
cord-332109-ont0tqpn	388	22	]	]	-RRB-
cord-332109-ont0tqpn	388	23	,	,	,
cord-332109-ont0tqpn	388	24	inhibits	inhibit	VBZ
cord-332109-ont0tqpn	388	25	viral	viral	JJ
cord-332109-ont0tqpn	388	26	RNA	RNA	NNP
cord-332109-ont0tqpn	388	27	replication	replication	NN
cord-332109-ont0tqpn	388	28	[	[	-LRB-
cord-332109-ont0tqpn	388	29	212	212	CD
cord-332109-ont0tqpn	388	30	]	]	-RRB-
cord-332109-ont0tqpn	388	31	.	.	.
cord-332109-ont0tqpn	389	1	Neutralizing	neutralize	VBG
cord-332109-ont0tqpn	389	2	antibodies	antibody	NNS
cord-332109-ont0tqpn	389	3	bind	bind	VBP
cord-332109-ont0tqpn	389	4	to	to	IN
cord-332109-ont0tqpn	389	5	RBD	RBD	NNP
cord-332109-ont0tqpn	389	6	of	of	IN
cord-332109-ont0tqpn	389	7	the	the	DT
cord-332109-ont0tqpn	389	8	S	S	NNP
cord-332109-ont0tqpn	389	9	protein	protein	NN
cord-332109-ont0tqpn	389	10	,	,	,
cord-332109-ont0tqpn	389	11	so	so	IN
cord-332109-ont0tqpn	389	12	the	the	DT
cord-332109-ont0tqpn	389	13	virus	virus	NN
cord-332109-ont0tqpn	389	14	can	can	MD
cord-332109-ont0tqpn	389	15	not	not	RB
cord-332109-ont0tqpn	389	16	bind	bind	VB
cord-332109-ont0tqpn	389	17	to	to	IN
cord-332109-ont0tqpn	389	18	ACE2	ACE2	NNP
cord-332109-ont0tqpn	389	19	.	.	.
cord-332109-ont0tqpn	390	1	However	however	RB
cord-332109-ont0tqpn	390	2	,	,	,
cord-332109-ont0tqpn	390	3	clearance	clearance	NN
cord-332109-ont0tqpn	390	4	of	of	IN
cord-332109-ont0tqpn	390	5	the	the	DT
cord-332109-ont0tqpn	390	6	virus	virus	NN
cord-332109-ont0tqpn	390	7	is	be	VBZ
cord-332109-ont0tqpn	390	8	heavily	heavily	RB
cord-332109-ont0tqpn	390	9	dependent	dependent	JJ
cord-332109-ont0tqpn	390	10	on	on	IN
cord-332109-ont0tqpn	390	11	the	the	DT
cord-332109-ont0tqpn	390	12	individual	individual	NN
cord-332109-ont0tqpn	390	13	's	's	POS
cord-332109-ont0tqpn	390	14	immune	immune	JJ
cord-332109-ont0tqpn	390	15	system	system	NN
cord-332109-ont0tqpn	390	16	,	,	,
cord-332109-ont0tqpn	390	17	including	include	VBG
cord-332109-ont0tqpn	390	18	activating	activate	VBG
cord-332109-ont0tqpn	390	19	phagocytes	phagocyte	NNS
cord-332109-ont0tqpn	390	20	and	and	CC
cord-332109-ont0tqpn	390	21	natural	natural	JJ
cord-332109-ont0tqpn	390	22	killer	killer	NN
cord-332109-ont0tqpn	390	23	cells	cell	NNS
cord-332109-ont0tqpn	390	24	.	.	.
cord-332109-ont0tqpn	391	1	As	as	IN
cord-332109-ont0tqpn	391	2	discussed	discuss	VBN
cord-332109-ont0tqpn	391	3	earlier	early	RBR
cord-332109-ont0tqpn	391	4	,	,	,
cord-332109-ont0tqpn	391	5	several	several	JJ
cord-332109-ont0tqpn	391	6	substances	substance	NNS
cord-332109-ont0tqpn	391	7	of	of	IN
cord-332109-ont0tqpn	391	8	abuse	abuse	NN
cord-332109-ont0tqpn	391	9	,	,	,
cord-332109-ont0tqpn	391	10	such	such	JJ
cord-332109-ont0tqpn	391	11	as	as	IN
cord-332109-ont0tqpn	391	12	nicotine	nicotine	NN
cord-332109-ont0tqpn	391	13	,	,	,
cord-332109-ont0tqpn	391	14	marijuana	marijuana	NN
cord-332109-ont0tqpn	391	15	,	,	,
cord-332109-ont0tqpn	391	16	cocaine	cocaine	NN
cord-332109-ont0tqpn	391	17	,	,	,
cord-332109-ont0tqpn	391	18	and	and	CC
cord-332109-ont0tqpn	391	19	amphetamines	amphetamine	NNS
cord-332109-ont0tqpn	391	20	,	,	,
cord-332109-ont0tqpn	391	21	have	have	VBP
cord-332109-ont0tqpn	391	22	shown	show	VBN
cord-332109-ont0tqpn	391	23	to	to	TO
cord-332109-ont0tqpn	391	24	suppress	suppress	VB
cord-332109-ont0tqpn	391	25	immune	immune	JJ
cord-332109-ont0tqpn	391	26	and	and	CC
cord-332109-ont0tqpn	391	27	antibody	antibody	NN
cord-332109-ont0tqpn	391	28	responses	response	NNS
cord-332109-ont0tqpn	391	29	.	.	.
cord-332109-ont0tqpn	392	1	Clinical	clinical	JJ
cord-332109-ont0tqpn	392	2	cases	case	NNS
cord-332109-ont0tqpn	392	3	indicated	indicate	VBD
cord-332109-ont0tqpn	392	4	that	that	IN
cord-332109-ont0tqpn	392	5	antibody	antibody	NN
cord-332109-ont0tqpn	392	6	-	-	HYPH
cord-332109-ont0tqpn	392	7	secreting	secrete	VBG
cord-332109-ont0tqpn	392	8	cells	cell	NNS
cord-332109-ont0tqpn	392	9	(	(	-LRB-
cord-332109-ont0tqpn	392	10	ASCs	ASCs	NNP
cord-332109-ont0tqpn	392	11	)	)	-RRB-
cord-332109-ont0tqpn	392	12	,	,	,
cord-332109-ont0tqpn	392	13	T	T	NNP
cord-332109-ont0tqpn	392	14	follicular	follicular	JJ
cord-332109-ont0tqpn	392	15	helper	helper	NN
cord-332109-ont0tqpn	392	16	(	(	-LRB-
cord-332109-ont0tqpn	392	17	T	T	NNP
cord-332109-ont0tqpn	392	18	FH	FH	NNP
cord-332109-ont0tqpn	392	19	)	)	-RRB-
cord-332109-ont0tqpn	392	20	cells	cell	NNS
cord-332109-ont0tqpn	392	21	,	,	,
cord-332109-ont0tqpn	392	22	as	as	RB
cord-332109-ont0tqpn	392	23	well	well	RB
cord-332109-ont0tqpn	392	24	as	as	IN
cord-332109-ont0tqpn	392	25	activated	activate	VBN
cord-332109-ont0tqpn	392	26	CD4	CD4	NNP
cord-332109-ont0tqpn	392	27	+	+	CC
cord-332109-ont0tqpn	392	28	and	and	CC
cord-332109-ont0tqpn	392	29	CD8	CD8	NNP
cord-332109-ont0tqpn	392	30	+	+	CC
cord-332109-ont0tqpn	392	31	T	T	NNP
cord-332109-ont0tqpn	392	32	-	-	HYPH
cord-332109-ont0tqpn	392	33	cells	cell	NNS
cord-332109-ont0tqpn	392	34	,	,	,
cord-332109-ont0tqpn	392	35	are	be	VBP
cord-332109-ont0tqpn	392	36	critical	critical	JJ
cord-332109-ont0tqpn	392	37	to	to	IN
cord-332109-ont0tqpn	392	38	symptomatic	symptomatic	JJ
cord-332109-ont0tqpn	392	39	recovery	recovery	NN
cord-332109-ont0tqpn	392	40	from	from	IN
cord-332109-ont0tqpn	392	41	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	392	42	[	[	-LRB-
cord-332109-ont0tqpn	392	43	237	237	CD
cord-332109-ont0tqpn	392	44	]	]	-RRB-
cord-332109-ont0tqpn	392	45	.	.	.
cord-332109-ont0tqpn	393	1	As	as	IN
cord-332109-ont0tqpn	393	2	a	a	DT
cord-332109-ont0tqpn	393	3	result	result	NN
cord-332109-ont0tqpn	393	4	,	,	,
cord-332109-ont0tqpn	393	5	SUD	SUD	NNP
cord-332109-ont0tqpn	393	6	-	-	HYPH
cord-332109-ont0tqpn	393	7	induced	induce	VBN
cord-332109-ont0tqpn	393	8	reduction	reduction	NN
cord-332109-ont0tqpn	393	9	of	of	IN
cord-332109-ont0tqpn	393	10	T	t	NN
cord-332109-ont0tqpn	393	11	-	-	HYPH
cord-332109-ont0tqpn	393	12	cell	cell	NN
cord-332109-ont0tqpn	393	13	activation	activation	NN
cord-332109-ont0tqpn	393	14	will	will	MD
cord-332109-ont0tqpn	393	15	dampen	dampen	VB
cord-332109-ont0tqpn	393	16	the	the	DT
cord-332109-ont0tqpn	393	17	ability	ability	NN
cord-332109-ont0tqpn	393	18	to	to	TO
cord-332109-ont0tqpn	393	19	efficiently	efficiently	RB
cord-332109-ont0tqpn	393	20	clear	clear	VB
cord-332109-ont0tqpn	393	21	the	the	DT
cord-332109-ont0tqpn	393	22	virus	virus	NN
cord-332109-ont0tqpn	393	23	from	from	IN
cord-332109-ont0tqpn	393	24	the	the	DT
cord-332109-ont0tqpn	393	25	body	body	NN
cord-332109-ont0tqpn	393	26	.	.	.
cord-332109-ont0tqpn	394	1	For	for	IN
cord-332109-ont0tqpn	394	2	vaccines	vaccine	NNS
cord-332109-ont0tqpn	394	3	to	to	TO
cord-332109-ont0tqpn	394	4	work	work	VB
cord-332109-ont0tqpn	394	5	efficiently	efficiently	RB
cord-332109-ont0tqpn	394	6	,	,	,
cord-332109-ont0tqpn	394	7	robust	robust	JJ
cord-332109-ont0tqpn	394	8	immune	immune	JJ
cord-332109-ont0tqpn	394	9	responses	response	NNS
cord-332109-ont0tqpn	394	10	are	be	VBP
cord-332109-ont0tqpn	394	11	required	require	VBN
cord-332109-ont0tqpn	394	12	.	.	.
cord-332109-ont0tqpn	395	1	CD4	CD4	NNP
cord-332109-ont0tqpn	395	2	+	+	CC
cord-332109-ont0tqpn	395	3	and	and	CC
cord-332109-ont0tqpn	395	4	CD8	CD8	NNP
cord-332109-ont0tqpn	395	5	+	+	CC
cord-332109-ont0tqpn	395	6	T	t	NN
cord-332109-ont0tqpn	395	7	-	-	HYPH
cord-332109-ont0tqpn	395	8	cell	cell	NN
cord-332109-ont0tqpn	395	9	responses	response	NNS
cord-332109-ont0tqpn	395	10	are	be	VBP
cord-332109-ont0tqpn	395	11	essential	essential	JJ
cord-332109-ont0tqpn	395	12	in	in	IN
cord-332109-ont0tqpn	395	13	protective	protective	JJ
cord-332109-ont0tqpn	395	14	antiviral	antiviral	JJ
cord-332109-ont0tqpn	395	15	immunity	immunity	NN
cord-332109-ont0tqpn	395	16	by	by	IN
cord-332109-ont0tqpn	395	17	vaccination	vaccination	NN
cord-332109-ont0tqpn	395	18	[	[	-LRB-
cord-332109-ont0tqpn	395	19	238	238	CD
cord-332109-ont0tqpn	395	20	,	,	,
cord-332109-ont0tqpn	395	21	239	239	CD
cord-332109-ont0tqpn	395	22	]	]	-RRB-
cord-332109-ont0tqpn	395	23	.	.	.
cord-332109-ont0tqpn	396	1	Due	due	IN
cord-332109-ont0tqpn	396	2	to	to	IN
cord-332109-ont0tqpn	396	3	the	the	DT
cord-332109-ont0tqpn	396	4	immunosuppression	immunosuppression	NN
cord-332109-ont0tqpn	396	5	and	and	CC
cord-332109-ont0tqpn	396	6	reduction	reduction	NN
cord-332109-ont0tqpn	396	7	of	of	IN
cord-332109-ont0tqpn	396	8	T	t	NN
cord-332109-ont0tqpn	396	9	-	-	HYPH
cord-332109-ont0tqpn	396	10	cell	cell	NN
cord-332109-ont0tqpn	396	11	responses	response	NNS
cord-332109-ont0tqpn	396	12	,	,	,
cord-332109-ont0tqpn	396	13	individuals	individual	NNS
cord-332109-ont0tqpn	396	14	with	with	IN
cord-332109-ont0tqpn	396	15	SUDs	sud	NNS
cord-332109-ont0tqpn	396	16	may	may	MD
cord-332109-ont0tqpn	396	17	not	not	RB
cord-332109-ont0tqpn	396	18	develop	develop	VB
cord-332109-ont0tqpn	396	19	sufficient	sufficient	JJ
cord-332109-ont0tqpn	396	20	protective	protective	JJ
cord-332109-ont0tqpn	396	21	antibodies	antibody	NNS
cord-332109-ont0tqpn	396	22	against	against	IN
cord-332109-ont0tqpn	396	23	the	the	DT
cord-332109-ont0tqpn	396	24	virus	virus	NN
cord-332109-ont0tqpn	396	25	.	.	.
cord-332109-ont0tqpn	397	1	A	a	DT
cord-332109-ont0tqpn	397	2	clinical	clinical	JJ
cord-332109-ont0tqpn	397	3	study	study	NN
cord-332109-ont0tqpn	397	4	suggested	suggest	VBD
cord-332109-ont0tqpn	397	5	that	that	IN
cord-332109-ont0tqpn	397	6	SARS	SARS	NNP
cord-332109-ont0tqpn	397	7	-	-	HYPH
cord-332109-ont0tqpn	397	8	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	397	9	specific	specific	JJ
cord-332109-ont0tqpn	397	10	immunoglobin	immunoglobin	NN
cord-332109-ont0tqpn	397	11	G	G	NNP
cord-332109-ont0tqpn	397	12	(	(	-LRB-
cord-332109-ont0tqpn	397	13	IgG	IgG	NNP
cord-332109-ont0tqpn	397	14	)	)	-RRB-
cord-332109-ont0tqpn	397	15	antibodies	antibody	NNS
cord-332109-ont0tqpn	397	16	may	may	MD
cord-332109-ont0tqpn	397	17	last	last	VB
cord-332109-ont0tqpn	397	18	only	only	RB
cord-332109-ont0tqpn	397	19	2	2	CD
cord-332109-ont0tqpn	397	20	-	-	SYM
cord-332109-ont0tqpn	397	21	3	3	CD
cord-332109-ont0tqpn	397	22	months	month	NNS
cord-332109-ont0tqpn	397	23	before	before	IN
cord-332109-ont0tqpn	397	24	a	a	DT
cord-332109-ont0tqpn	397	25	steep	steep	JJ
cord-332109-ont0tqpn	397	26	decline	decline	NN
cord-332109-ont0tqpn	397	27	in	in	IN
cord-332109-ont0tqpn	398	1	both	both	DT
cord-332109-ont0tqpn	398	2	asymptomatic	asymptomatic	JJ
cord-332109-ont0tqpn	398	3	and	and	CC
cord-332109-ont0tqpn	398	4	mildly	mildly	RB
cord-332109-ont0tqpn	398	5	symptomatic	symptomatic	JJ
cord-332109-ont0tqpn	398	6	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	398	7	patients	patient	NNS
cord-332109-ont0tqpn	398	8	[	[	-LRB-
cord-332109-ont0tqpn	398	9	240	240	CD
cord-332109-ont0tqpn	398	10	]	]	-RRB-
cord-332109-ont0tqpn	398	11	.	.	.
cord-332109-ont0tqpn	399	1	Considering	consider	VBG
cord-332109-ont0tqpn	399	2	their	-PRON-	PRP$
cord-332109-ont0tqpn	399	3	substantially	substantially	RB
cord-332109-ont0tqpn	399	4	undermined	undermine	VBN
cord-332109-ont0tqpn	399	5	immune	immune	JJ
cord-332109-ont0tqpn	399	6	systems	system	NNS
cord-332109-ont0tqpn	399	7	,	,	,
cord-332109-ont0tqpn	399	8	the	the	DT
cord-332109-ont0tqpn	399	9	protective	protective	JJ
cord-332109-ont0tqpn	399	10	antibodies	antibody	NNS
cord-332109-ont0tqpn	399	11	in	in	IN
cord-332109-ont0tqpn	399	12	patients	patient	NNS
cord-332109-ont0tqpn	399	13	with	with	IN
cord-332109-ont0tqpn	399	14	SUDs	sud	NNS
cord-332109-ont0tqpn	399	15	are	be	VBP
cord-332109-ont0tqpn	399	16	very	very	RB
cord-332109-ont0tqpn	399	17	likely	likely	JJ
cord-332109-ont0tqpn	399	18	to	to	TO
cord-332109-ont0tqpn	399	19	decline	decline	VB
cord-332109-ont0tqpn	399	20	much	much	RB
cord-332109-ont0tqpn	399	21	quicker	quick	RBR
cord-332109-ont0tqpn	399	22	,	,	,
cord-332109-ont0tqpn	399	23	making	make	VBG
cord-332109-ont0tqpn	399	24	vaccines	vaccine	NNS
cord-332109-ont0tqpn	399	25	considerably	considerably	RB
cord-332109-ont0tqpn	399	26	less	less	RBR
cord-332109-ont0tqpn	399	27	effective	effective	JJ
cord-332109-ont0tqpn	399	28	in	in	IN
cord-332109-ont0tqpn	399	29	these	these	DT
cord-332109-ont0tqpn	399	30	patients	patient	NNS
cord-332109-ont0tqpn	399	31	.	.	.
cord-332109-ont0tqpn	400	1	There	there	EX
cord-332109-ont0tqpn	400	2	is	be	VBZ
cord-332109-ont0tqpn	400	3	a	a	DT
cord-332109-ont0tqpn	400	4	potential	potential	JJ
cord-332109-ont0tqpn	400	5	risk	risk	NN
cord-332109-ont0tqpn	400	6	,	,	,
cord-332109-ont0tqpn	400	7	although	although	IN
cord-332109-ont0tqpn	400	8	no	no	DT
cord-332109-ont0tqpn	400	9	reported	report	VBN
cord-332109-ont0tqpn	400	10	cases	case	NNS
cord-332109-ont0tqpn	400	11	yet	yet	RB
cord-332109-ont0tqpn	400	12	,	,	,
cord-332109-ont0tqpn	400	13	that	that	IN
cord-332109-ont0tqpn	400	14	antibodies	antibody	NNS
cord-332109-ont0tqpn	400	15	or	or	CC
cord-332109-ont0tqpn	400	16	vaccines	vaccine	NNS
cord-332109-ont0tqpn	400	17	may	may	MD
cord-332109-ont0tqpn	400	18	promote	promote	VB
cord-332109-ont0tqpn	400	19	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	400	20	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	400	21	through	through	IN
cord-332109-ont0tqpn	400	22	antibody	antibody	NN
cord-332109-ont0tqpn	400	23	-	-	HYPH
cord-332109-ont0tqpn	400	24	dependent	dependent	JJ
cord-332109-ont0tqpn	400	25	enhancement	enhancement	NN
cord-332109-ont0tqpn	400	26	(	(	-LRB-
cord-332109-ont0tqpn	400	27	ADE	ADE	NNP
cord-332109-ont0tqpn	400	28	)	)	-RRB-
cord-332109-ont0tqpn	400	29	.	.	.
cord-332109-ont0tqpn	401	1	While	while	IN
cord-332109-ont0tqpn	401	2	SUDs	sud	NNS
cord-332109-ont0tqpn	401	3	compromise	compromise	VBP
cord-332109-ont0tqpn	401	4	the	the	DT
cord-332109-ont0tqpn	401	5	immune	immune	JJ
cord-332109-ont0tqpn	401	6	system	system	NN
cord-332109-ont0tqpn	401	7	,	,	,
cord-332109-ont0tqpn	401	8	virus	virus	NN
cord-332109-ont0tqpn	401	9	-	-	HYPH
cord-332109-ont0tqpn	401	10	specific	specific	JJ
cord-332109-ont0tqpn	401	11	antibodies	antibody	NNS
cord-332109-ont0tqpn	401	12	are	be	VBP
cord-332109-ont0tqpn	401	13	likely	likely	JJ
cord-332109-ont0tqpn	401	14	to	to	TO
cord-332109-ont0tqpn	401	15	promote	promote	VB
cord-332109-ont0tqpn	401	16	viral	viral	JJ
cord-332109-ont0tqpn	401	17	entry	entry	NN
cord-332109-ont0tqpn	401	18	into	into	IN
cord-332109-ont0tqpn	401	19	various	various	JJ
cord-332109-ont0tqpn	401	20	immune	immune	JJ
cord-332109-ont0tqpn	401	21	cells	cell	NNS
cord-332109-ont0tqpn	401	22	,	,	,
cord-332109-ont0tqpn	401	23	including	include	VBG
cord-332109-ont0tqpn	401	24	monocytes	monocyte	NNS
cord-332109-ont0tqpn	401	25	,	,	,
cord-332109-ont0tqpn	401	26	macrophages	macrophage	NNS
cord-332109-ont0tqpn	401	27	,	,	,
cord-332109-ont0tqpn	401	28	and	and	CC
cord-332109-ont0tqpn	401	29	B	b	NN
cord-332109-ont0tqpn	401	30	cells	cell	NNS
cord-332109-ont0tqpn	401	31	[	[	-LRB-
cord-332109-ont0tqpn	401	32	241	241	CD
cord-332109-ont0tqpn	401	33	,	,	,
cord-332109-ont0tqpn	401	34	242	242	CD
cord-332109-ont0tqpn	401	35	]	]	-RRB-
cord-332109-ont0tqpn	401	36	,	,	,
cord-332109-ont0tqpn	401	37	which	which	WDT
cord-332109-ont0tqpn	401	38	may	may	MD
cord-332109-ont0tqpn	401	39	further	further	RB
cord-332109-ont0tqpn	401	40	deteriorate	deteriorate	VB
cord-332109-ont0tqpn	401	41	the	the	DT
cord-332109-ont0tqpn	401	42	immune	immune	JJ
cord-332109-ont0tqpn	401	43	response	response	NN
cord-332109-ont0tqpn	401	44	towards	towards	IN
cord-332109-ont0tqpn	401	45	the	the	DT
cord-332109-ont0tqpn	401	46	virus	virus	NN
cord-332109-ont0tqpn	401	47	.	.	.
cord-332109-ont0tqpn	402	1	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	402	2	pandemic	pandemic	NN
cord-332109-ont0tqpn	402	3	poses	pose	VBZ
cord-332109-ont0tqpn	402	4	tremendous	tremendous	JJ
cord-332109-ont0tqpn	402	5	challenges	challenge	NNS
cord-332109-ont0tqpn	402	6	for	for	IN
cord-332109-ont0tqpn	402	7	the	the	DT
cord-332109-ont0tqpn	402	8	treatment	treatment	NN
cord-332109-ont0tqpn	402	9	of	of	IN
cord-332109-ont0tqpn	402	10	SUDs	sud	NNS
cord-332109-ont0tqpn	402	11	[	[	-LRB-
cord-332109-ont0tqpn	402	12	243	243	CD
cord-332109-ont0tqpn	402	13	]	]	-RRB-
cord-332109-ont0tqpn	402	14	.	.	.
cord-332109-ont0tqpn	403	1	The	the	DT
cord-332109-ont0tqpn	403	2	regulatory	regulatory	JJ
cord-332109-ont0tqpn	403	3	and	and	CC
cord-332109-ont0tqpn	403	4	policy	policy	NN
cord-332109-ont0tqpn	403	5	obstacles	obstacle	NNS
cord-332109-ont0tqpn	403	6	for	for	IN
cord-332109-ont0tqpn	403	7	patients	patient	NNS
cord-332109-ont0tqpn	403	8	with	with	IN
cord-332109-ont0tqpn	403	9	SUDs	sud	NNS
cord-332109-ont0tqpn	403	10	are	be	VBP
cord-332109-ont0tqpn	403	11	intensified	intensify	VBN
cord-332109-ont0tqpn	403	12	in	in	IN
cord-332109-ont0tqpn	403	13	the	the	DT
cord-332109-ont0tqpn	403	14	times	time	NNS
cord-332109-ont0tqpn	403	15	of	of	IN
cord-332109-ont0tqpn	403	16	crisis	crisis	NN
cord-332109-ont0tqpn	403	17	,	,	,
cord-332109-ont0tqpn	403	18	making	make	VBG
cord-332109-ont0tqpn	403	19	it	-PRON-	PRP
cord-332109-ont0tqpn	403	20	more	more	RBR
cord-332109-ont0tqpn	403	21	difficult	difficult	JJ
cord-332109-ont0tqpn	403	22	for	for	IN
cord-332109-ont0tqpn	403	23	healthcare	healthcare	NN
cord-332109-ont0tqpn	403	24	providers	provider	NNS
cord-332109-ont0tqpn	403	25	to	to	TO
cord-332109-ont0tqpn	403	26	address	address	VB
cord-332109-ont0tqpn	403	27	the	the	DT
cord-332109-ont0tqpn	403	28	needs	need	NNS
cord-332109-ont0tqpn	403	29	of	of	IN
cord-332109-ont0tqpn	403	30	SUD	SUD	NNP
cord-332109-ont0tqpn	403	31	patients	patient	NNS
cord-332109-ont0tqpn	403	32	with	with	IN
cord-332109-ont0tqpn	403	33	the	the	DT
cord-332109-ont0tqpn	403	34	availability	availability	NN
cord-332109-ont0tqpn	403	35	of	of	IN
cord-332109-ont0tqpn	403	36	medications	medication	NNS
cord-332109-ont0tqpn	403	37	.	.	.
cord-332109-ont0tqpn	404	1	Physical	physical	JJ
cord-332109-ont0tqpn	404	2	and	and	CC
cord-332109-ont0tqpn	404	3	social	social	JJ
cord-332109-ont0tqpn	404	4	distancing	distancing	NN
cord-332109-ont0tqpn	404	5	requirement	requirement	NN
cord-332109-ont0tqpn	404	6	renders	render	VBZ
cord-332109-ont0tqpn	404	7	the	the	DT
cord-332109-ont0tqpn	404	8	face	face	NN
cord-332109-ont0tqpn	404	9	-	-	HYPH
cord-332109-ont0tqpn	404	10	to	to	IN
cord-332109-ont0tqpn	404	11	-	-	HYPH
cord-332109-ont0tqpn	404	12	face	face	NN
cord-332109-ont0tqpn	404	13	group	group	NN
cord-332109-ont0tqpn	404	14	treatment	treatment	NN
cord-332109-ont0tqpn	404	15	and	and	CC
cord-332109-ont0tqpn	404	16	mutual	mutual	JJ
cord-332109-ont0tqpn	404	17	support	support	NN
cord-332109-ont0tqpn	404	18	groups	group	NNS
cord-332109-ont0tqpn	404	19	inaccessible	inaccessible	JJ
cord-332109-ont0tqpn	404	20	.	.	.
cord-332109-ont0tqpn	405	1	These	these	DT
cord-332109-ont0tqpn	405	2	difficulties	difficulty	NNS
cord-332109-ont0tqpn	405	3	will	will	MD
cord-332109-ont0tqpn	405	4	disrupt	disrupt	VB
cord-332109-ont0tqpn	405	5	the	the	DT
cord-332109-ont0tqpn	405	6	treatment	treatment	NN
cord-332109-ont0tqpn	405	7	of	of	IN
cord-332109-ont0tqpn	405	8	patients	patient	NNS
cord-332109-ont0tqpn	405	9	with	with	IN
cord-332109-ont0tqpn	405	10	SUDs	sud	NNS
cord-332109-ont0tqpn	405	11	when	when	WRB
cord-332109-ont0tqpn	405	12	these	these	DT
cord-332109-ont0tqpn	405	13	patients	patient	NNS
cord-332109-ont0tqpn	405	14	start	start	VBP
cord-332109-ont0tqpn	405	15	to	to	TO
cord-332109-ont0tqpn	405	16	experience	experience	VB
cord-332109-ont0tqpn	405	17	withdrawal	withdrawal	NN
cord-332109-ont0tqpn	405	18	symptoms	symptom	NNS
cord-332109-ont0tqpn	405	19	.	.	.
cord-332109-ont0tqpn	406	1	It	-PRON-	PRP
cord-332109-ont0tqpn	406	2	has	have	VBZ
cord-332109-ont0tqpn	406	3	been	be	VBN
cord-332109-ont0tqpn	406	4	called	call	VBN
cord-332109-ont0tqpn	406	5	for	for	IN
cord-332109-ont0tqpn	406	6	relaxing	relax	VBG
cord-332109-ont0tqpn	406	7	rules	rule	NNS
cord-332109-ont0tqpn	406	8	and	and	CC
cord-332109-ont0tqpn	406	9	regulations	regulation	NNS
cord-332109-ont0tqpn	406	10	for	for	IN
cord-332109-ont0tqpn	406	11	these	these	DT
cord-332109-ont0tqpn	406	12	patients	patient	NNS
cord-332109-ont0tqpn	406	13	to	to	TO
cord-332109-ont0tqpn	406	14	receive	receive	VB
cord-332109-ont0tqpn	406	15	treatment	treatment	NN
cord-332109-ont0tqpn	406	16	,	,	,
cord-332109-ont0tqpn	406	17	and	and	CC
cord-332109-ont0tqpn	406	18	adopting	adopt	VBG
cord-332109-ont0tqpn	406	19	the	the	DT
cord-332109-ont0tqpn	406	20	model	model	NN
cord-332109-ont0tqpn	406	21	of	of	IN
cord-332109-ont0tqpn	406	22	pharmacy	pharmacy	NN
cord-332109-ont0tqpn	406	23	-	-	HYPH
cord-332109-ont0tqpn	406	24	based	base	VBN
cord-332109-ont0tqpn	406	25	addiction	addiction	NN
cord-332109-ont0tqpn	406	26	care	care	NN
cord-332109-ont0tqpn	406	27	by	by	IN
cord-332109-ont0tqpn	406	28	integrating	integrate	VBG
cord-332109-ont0tqpn	406	29	primary	primary	JJ
cord-332109-ont0tqpn	406	30	-	-	HYPH
cord-332109-ont0tqpn	406	31	care	care	NN
cord-332109-ont0tqpn	406	32	and	and	CC
cord-332109-ont0tqpn	406	33	pharmacy	pharmacy	NN
cord-332109-ont0tqpn	406	34	prescription	prescription	NN
cord-332109-ont0tqpn	406	35	,	,	,
cord-332109-ont0tqpn	406	36	dispense	dispense	VB
cord-332109-ont0tqpn	406	37	,	,	,
cord-332109-ont0tqpn	406	38	and	and	CC
cord-332109-ont0tqpn	406	39	management	management	NN
cord-332109-ont0tqpn	406	40	[	[	-LRB-
cord-332109-ont0tqpn	406	41	243	243	CD
cord-332109-ont0tqpn	406	42	]	]	-RRB-
cord-332109-ont0tqpn	406	43	.	.	.
cord-332109-ont0tqpn	407	1	It	-PRON-	PRP
cord-332109-ont0tqpn	407	2	is	be	VBZ
cord-332109-ont0tqpn	407	3	now	now	RB
cord-332109-ont0tqpn	407	4	widely	widely	RB
cord-332109-ont0tqpn	407	5	accepted	accept	VBN
cord-332109-ont0tqpn	407	6	that	that	IN
cord-332109-ont0tqpn	407	7	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	407	8	may	may	MD
cord-332109-ont0tqpn	407	9	stay	stay	VB
cord-332109-ont0tqpn	407	10	with	with	IN
cord-332109-ont0tqpn	407	11	us	-PRON-	PRP
cord-332109-ont0tqpn	407	12	for	for	IN
cord-332109-ont0tqpn	407	13	some	some	DT
cord-332109-ont0tqpn	407	14	extended	extended	JJ
cord-332109-ont0tqpn	407	15	periods	period	NNS
cord-332109-ont0tqpn	407	16	.	.	.
cord-332109-ont0tqpn	408	1	People	People	NNS
cord-332109-ont0tqpn	408	2	with	with	IN
cord-332109-ont0tqpn	408	3	mild	mild	JJ
cord-332109-ont0tqpn	408	4	or	or	CC
cord-332109-ont0tqpn	408	5	no	no	DT
cord-332109-ont0tqpn	408	6	symptoms	symptom	NNS
cord-332109-ont0tqpn	408	7	can	can	MD
cord-332109-ont0tqpn	408	8	transmit	transmit	VB
cord-332109-ont0tqpn	408	9	the	the	DT
cord-332109-ont0tqpn	408	10	pathogen	pathogen	NN
cord-332109-ont0tqpn	408	11	as	as	RB
cord-332109-ont0tqpn	408	12	effectively	effectively	RB
cord-332109-ont0tqpn	408	13	as	as	IN
cord-332109-ont0tqpn	408	14	those	those	DT
cord-332109-ont0tqpn	408	15	with	with	IN
cord-332109-ont0tqpn	408	16	severe	severe	JJ
cord-332109-ont0tqpn	408	17	symptoms	symptom	NNS
cord-332109-ont0tqpn	408	18	[	[	-LRB-
cord-332109-ont0tqpn	408	19	244	244	CD
cord-332109-ont0tqpn	408	20	,	,	,
cord-332109-ont0tqpn	408	21	245	245	CD
cord-332109-ont0tqpn	408	22	]	]	-RRB-
cord-332109-ont0tqpn	408	23	.	.	.
cord-332109-ont0tqpn	409	1	The	the	DT
cord-332109-ont0tqpn	409	2	complications	complication	NNS
cord-332109-ont0tqpn	409	3	and	and	CC
cord-332109-ont0tqpn	409	4	compromised	compromised	JJ
cord-332109-ont0tqpn	409	5	immune	immune	JJ
cord-332109-ont0tqpn	409	6	systems	system	NNS
cord-332109-ont0tqpn	409	7	associated	associate	VBN
cord-332109-ont0tqpn	409	8	with	with	IN
cord-332109-ont0tqpn	409	9	SUDs	sud	NNS
cord-332109-ont0tqpn	409	10	make	make	VBP
cord-332109-ont0tqpn	409	11	drug	drug	NN
cord-332109-ont0tqpn	409	12	abusers	abuser	NNS
cord-332109-ont0tqpn	409	13	particularly	particularly	RB
cord-332109-ont0tqpn	409	14	vulnerable	vulnerable	JJ
cord-332109-ont0tqpn	409	15	to	to	IN
cord-332109-ont0tqpn	409	16	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	409	17	.	.	.
cord-332109-ont0tqpn	410	1	Therapeutics	therapeutic	NNS
cord-332109-ont0tqpn	410	2	and	and	CC
cord-332109-ont0tqpn	410	3	vaccines	vaccine	NNS
cord-332109-ont0tqpn	410	4	currently	currently	RB
cord-332109-ont0tqpn	410	5	under	under	IN
cord-332109-ont0tqpn	410	6	development	development	NN
cord-332109-ont0tqpn	410	7	do	do	VBP
cord-332109-ont0tqpn	410	8	not	not	RB
cord-332109-ont0tqpn	410	9	address	address	VB
cord-332109-ont0tqpn	410	10	the	the	DT
cord-332109-ont0tqpn	410	11	specific	specific	JJ
cord-332109-ont0tqpn	410	12	concerns	concern	NNS
cord-332109-ont0tqpn	410	13	and	and	CC
cord-332109-ont0tqpn	410	14	risk	risk	NN
cord-332109-ont0tqpn	410	15	factors	factor	NNS
cord-332109-ont0tqpn	410	16	for	for	IN
cord-332109-ont0tqpn	410	17	these	these	DT
cord-332109-ont0tqpn	410	18	individuals	individual	NNS
cord-332109-ont0tqpn	410	19	.	.	.
cord-332109-ont0tqpn	411	1	There	there	EX
cord-332109-ont0tqpn	411	2	are	be	VBP
cord-332109-ont0tqpn	411	3	even	even	RB
cord-332109-ont0tqpn	411	4	greater	great	JJR
cord-332109-ont0tqpn	411	5	challenges	challenge	NNS
cord-332109-ont0tqpn	411	6	for	for	IN
cord-332109-ont0tqpn	411	7	people	people	NNS
cord-332109-ont0tqpn	411	8	with	with	IN
cord-332109-ont0tqpn	411	9	SUDs	sud	NNS
cord-332109-ont0tqpn	411	10	under	under	IN
cord-332109-ont0tqpn	411	11	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	411	12	pandemic	pandemic	NN
cord-332109-ont0tqpn	411	13	,	,	,
cord-332109-ont0tqpn	411	14	as	as	IN
cord-332109-ont0tqpn	411	15	they	-PRON-	PRP
cord-332109-ont0tqpn	411	16	will	will	MD
cord-332109-ont0tqpn	411	17	experience	experience	VB
cord-332109-ont0tqpn	411	18	a	a	DT
cord-332109-ont0tqpn	411	19	higher	high	JJR
cord-332109-ont0tqpn	411	20	infectious	infectious	JJ
cord-332109-ont0tqpn	411	21	rate	rate	NN
cord-332109-ont0tqpn	411	22	,	,	,
cord-332109-ont0tqpn	411	23	limited	limited	JJ
cord-332109-ont0tqpn	411	24	access	access	NN
cord-332109-ont0tqpn	411	25	to	to	IN
cord-332109-ont0tqpn	411	26	healthcare	healthcare	NN
cord-332109-ont0tqpn	411	27	system	system	NN
cord-332109-ont0tqpn	411	28	and	and	CC
cord-332109-ont0tqpn	411	29	support	support	NN
cord-332109-ont0tqpn	411	30	groups	group	NNS
cord-332109-ont0tqpn	411	31	,	,	,
cord-332109-ont0tqpn	411	32	inadequate	inadequate	JJ
cord-332109-ont0tqpn	411	33	food	food	NN
cord-332109-ont0tqpn	411	34	and	and	CC
cord-332109-ont0tqpn	411	35	housing	housing	NN
cord-332109-ont0tqpn	411	36	,	,	,
cord-332109-ont0tqpn	411	37	and	and	CC
cord-332109-ont0tqpn	411	38	increased	increase	VBN
cord-332109-ont0tqpn	411	39	likelihood	likelihood	NN
cord-332109-ont0tqpn	411	40	of	of	IN
cord-332109-ont0tqpn	411	41	homelessness	homelessness	NN
cord-332109-ont0tqpn	411	42	and	and	CC
cord-332109-ont0tqpn	411	43	incarceration	incarceration	NN
cord-332109-ont0tqpn	411	44	.	.	.
cord-332109-ont0tqpn	412	1	They	-PRON-	PRP
cord-332109-ont0tqpn	412	2	may	may	MD
cord-332109-ont0tqpn	412	3	also	also	RB
cord-332109-ont0tqpn	412	4	face	face	VB
cord-332109-ont0tqpn	412	5	excessive	excessive	JJ
cord-332109-ont0tqpn	412	6	discrimination	discrimination	NN
cord-332109-ont0tqpn	412	7	,	,	,
cord-332109-ont0tqpn	412	8	and	and	CC
cord-332109-ont0tqpn	412	9	have	have	VBP
cord-332109-ont0tqpn	412	10	higher	high	JJR
cord-332109-ont0tqpn	412	11	chances	chance	NNS
cord-332109-ont0tqpn	412	12	of	of	IN
cord-332109-ont0tqpn	412	13	relapses	relapse	NNS
cord-332109-ont0tqpn	412	14	and	and	CC
cord-332109-ont0tqpn	412	15	overdose	overdose	NN
cord-332109-ont0tqpn	412	16	death	death	NN
cord-332109-ont0tqpn	412	17	.	.	.
cord-332109-ont0tqpn	413	1	The	the	DT
cord-332109-ont0tqpn	413	2	research	research	NN
cord-332109-ont0tqpn	413	3	community	community	NN
cord-332109-ont0tqpn	413	4	should	should	MD
cord-332109-ont0tqpn	413	5	heed	heed	VB
cord-332109-ont0tqpn	413	6	to	to	IN
cord-332109-ont0tqpn	413	7	the	the	DT
cord-332109-ont0tqpn	413	8	challenges	challenge	NNS
cord-332109-ont0tqpn	413	9	and	and	CC
cord-332109-ont0tqpn	413	10	difficulties	difficulty	NNS
cord-332109-ont0tqpn	413	11	these	these	DT
cord-332109-ont0tqpn	413	12	individuals	individual	NNS
cord-332109-ont0tqpn	413	13	may	may	MD
cord-332109-ont0tqpn	413	14	experience	experience	VB
cord-332109-ont0tqpn	413	15	in	in	IN
cord-332109-ont0tqpn	413	16	the	the	DT
cord-332109-ont0tqpn	413	17	pandemic	pandemic	NN
cord-332109-ont0tqpn	413	18	,	,	,
cord-332109-ont0tqpn	413	19	uncover	uncover	VB
cord-332109-ont0tqpn	413	20	scientific	scientific	JJ
cord-332109-ont0tqpn	413	21	evidence	evidence	NN
cord-332109-ont0tqpn	413	22	to	to	TO
cord-332109-ont0tqpn	413	23	link	link	VB
cord-332109-ont0tqpn	413	24	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	413	25	severity	severity	NN
cord-332109-ont0tqpn	413	26	and	and	CC
cord-332109-ont0tqpn	413	27	mortality	mortality	NN
cord-332109-ont0tqpn	413	28	with	with	IN
cord-332109-ont0tqpn	413	29	substance	substance	NN
cord-332109-ont0tqpn	413	30	use	use	NN
cord-332109-ont0tqpn	413	31	,	,	,
cord-332109-ont0tqpn	413	32	and	and	CC
cord-332109-ont0tqpn	413	33	advance	advance	VB
cord-332109-ont0tqpn	413	34	effective	effective	JJ
cord-332109-ont0tqpn	413	35	treatment	treatment	NN
cord-332109-ont0tqpn	413	36	and	and	CC
cord-332109-ont0tqpn	413	37	prevention	prevention	NN
cord-332109-ont0tqpn	413	38	strategies	strategy	NNS
cord-332109-ont0tqpn	413	39	for	for	IN
cord-332109-ont0tqpn	413	40	people	people	NNS
cord-332109-ont0tqpn	413	41	with	with	IN
cord-332109-ont0tqpn	413	42	SUDs	sud	NNS
cord-332109-ont0tqpn	413	43	.	.	.
cord-332109-ont0tqpn	414	1	Author	Author	NNP
cord-332109-ont0tqpn	414	2	Contributions	contribution	NNS
cord-332109-ont0tqpn	414	3	:	:	:
cord-332109-ont0tqpn	414	4	Conceptualization	conceptualization	NN
cord-332109-ont0tqpn	414	5	,	,	,
cord-332109-ont0tqpn	414	6	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	7	;	;	:
cord-332109-ont0tqpn	414	8	methodology	methodology	NN
cord-332109-ont0tqpn	414	9	,	,	,
cord-332109-ont0tqpn	414	10	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	11	and	and	CC
cord-332109-ont0tqpn	414	12	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	13	;	;	,
cord-332109-ont0tqpn	414	14	formal	formal	JJ
cord-332109-ont0tqpn	414	15	analysis	analysis	NN
cord-332109-ont0tqpn	414	16	,	,	,
cord-332109-ont0tqpn	414	17	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	18	and	and	CC
cord-332109-ont0tqpn	414	19	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	20	;	;	:
cord-332109-ont0tqpn	414	21	resources	resource	NNS
cord-332109-ont0tqpn	414	22	,	,	,
cord-332109-ont0tqpn	414	23	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	24	and	and	CC
cord-332109-ont0tqpn	414	25	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	26	;	;	:
cord-332109-ont0tqpn	414	27	data	datum	NNS
cord-332109-ont0tqpn	414	28	curation	curation	NN
cord-332109-ont0tqpn	414	29	,	,	,
cord-332109-ont0tqpn	414	30	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	31	and	and	CC
cord-332109-ont0tqpn	414	32	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	33	;	;	:
cord-332109-ont0tqpn	414	34	writing	write	VBG
cord-332109-ont0tqpn	414	35	-	-	HYPH
cord-332109-ont0tqpn	414	36	original	original	JJ
cord-332109-ont0tqpn	414	37	draft	draft	NN
cord-332109-ont0tqpn	414	38	preparation	preparation	NN
cord-332109-ont0tqpn	414	39	,	,	,
cord-332109-ont0tqpn	414	40	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	41	and	and	CC
cord-332109-ont0tqpn	414	42	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	43	;	;	:
cord-332109-ont0tqpn	414	44	writing	write	VBG
cord-332109-ont0tqpn	414	45	-	-	HYPH
cord-332109-ont0tqpn	414	46	review	review	NN
cord-332109-ont0tqpn	414	47	and	and	CC
cord-332109-ont0tqpn	414	48	editing	editing	NN
cord-332109-ont0tqpn	414	49	,	,	,
cord-332109-ont0tqpn	414	50	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	51	and	and	CC
cord-332109-ont0tqpn	414	52	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	53	;	;	:
cord-332109-ont0tqpn	414	54	visualization	visualization	NN
cord-332109-ont0tqpn	414	55	,	,	,
cord-332109-ont0tqpn	414	56	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	57	and	and	CC
cord-332109-ont0tqpn	414	58	R.S.	R.S.	NNP
cord-332109-ont0tqpn	414	59	;	;	:
cord-332109-ont0tqpn	414	60	supervision	supervision	NN
cord-332109-ont0tqpn	414	61	,	,	,
cord-332109-ont0tqpn	414	62	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	63	;	;	:
cord-332109-ont0tqpn	414	64	project	project	NN
cord-332109-ont0tqpn	414	65	administration	administration	NN
cord-332109-ont0tqpn	414	66	,	,	,
cord-332109-ont0tqpn	414	67	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	414	68	;	;	:
cord-332109-ont0tqpn	414	69	funding	funding	NN
cord-332109-ont0tqpn	414	70	acquisition	acquisition	NN
cord-332109-ont0tqpn	414	71	,	,	,
cord-332109-ont0tqpn	414	72	Y.W.	Y.W.	NNP
cord-332109-ont0tqpn	415	1	All	all	DT
cord-332109-ont0tqpn	415	2	authors	author	NNS
cord-332109-ont0tqpn	415	3	have	have	VBP
cord-332109-ont0tqpn	415	4	read	read	VBN
cord-332109-ont0tqpn	415	5	and	and	CC
cord-332109-ont0tqpn	415	6	agreed	agree	VBN
cord-332109-ont0tqpn	415	7	to	to	IN
cord-332109-ont0tqpn	415	8	the	the	DT
cord-332109-ont0tqpn	415	9	published	publish	VBN
cord-332109-ont0tqpn	415	10	version	version	NN
cord-332109-ont0tqpn	415	11	of	of	IN
cord-332109-ont0tqpn	415	12	the	the	DT
cord-332109-ont0tqpn	415	13	manuscript	manuscript	NN
cord-332109-ont0tqpn	415	14	.	.	.
cord-332109-ont0tqpn	415	15	 	 	_SP
cord-332109-ont0tqpn	416	1	Coronaviridae	Coronaviridae	NNP
cord-332109-ont0tqpn	416	2	Study	Study	NNP
cord-332109-ont0tqpn	416	3	Group	Group	NNP
cord-332109-ont0tqpn	416	4	of	of	IN
cord-332109-ont0tqpn	416	5	the	the	DT
cord-332109-ont0tqpn	416	6	International	International	NNP
cord-332109-ont0tqpn	416	7	Committee	Committee	NNP
cord-332109-ont0tqpn	416	8	on	on	IN
cord-332109-ont0tqpn	416	9	Taxonomy	Taxonomy	NNP
cord-332109-ont0tqpn	416	10	of	of	IN
cord-332109-ont0tqpn	416	11	Viruses	Viruses	NNPS
cord-332109-ont0tqpn	416	12	.	.	.
cord-332109-ont0tqpn	417	1	The	the	DT
cord-332109-ont0tqpn	417	2	species	specie	NNS
cord-332109-ont0tqpn	417	3	Severe	severe	JJ
cord-332109-ont0tqpn	417	4	acute	acute	JJ
cord-332109-ont0tqpn	417	5	respiratory	respiratory	JJ
cord-332109-ont0tqpn	417	6	syndrome	syndrome	NN
cord-332109-ont0tqpn	417	7	-	-	HYPH
cord-332109-ont0tqpn	417	8	related	relate	VBN
cord-332109-ont0tqpn	417	9	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	417	10	:	:	:
cord-332109-ont0tqpn	417	11	Classifying	classify	VBG
cord-332109-ont0tqpn	417	12	2019-nCoV	2019-ncov	CD
cord-332109-ont0tqpn	417	13	and	and	CC
cord-332109-ont0tqpn	417	14	naming	name	VBG
cord-332109-ont0tqpn	417	15	it	-PRON-	PRP
cord-332109-ont0tqpn	417	16	SARS	SARS	NNP
cord-332109-ont0tqpn	417	17	-	-	HYPH
cord-332109-ont0tqpn	417	18	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	418	1	A	a	DT
cord-332109-ont0tqpn	418	2	Novel	Novel	NNP
cord-332109-ont0tqpn	418	3	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	418	4	from	from	IN
cord-332109-ont0tqpn	418	5	Patients	patient	NNS
cord-332109-ont0tqpn	418	6	with	with	IN
cord-332109-ont0tqpn	418	7	Pneumonia	Pneumonia	NNP
cord-332109-ont0tqpn	418	8	in	in	IN
cord-332109-ont0tqpn	418	9	China	China	NNP
cord-332109-ont0tqpn	418	10	World	World	NNP
cord-332109-ont0tqpn	418	11	Health	Health	NNP
cord-332109-ont0tqpn	418	12	Organization	Organization	NNP
cord-332109-ont0tqpn	418	13	.	.	.
cord-332109-ont0tqpn	419	1	WHO	who	WP
cord-332109-ont0tqpn	419	2	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	419	3	Disease	Disease	NNP
cord-332109-ont0tqpn	419	4	(	(	-LRB-
cord-332109-ont0tqpn	419	5	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	419	6	)	)	-RRB-
cord-332109-ont0tqpn	419	7	Dashboard	Dashboard	NNP
cord-332109-ont0tqpn	419	8	World	World	NNP
cord-332109-ont0tqpn	419	9	Health	Health	NNP
cord-332109-ont0tqpn	419	10	Organization	Organization	NNP
cord-332109-ont0tqpn	419	11	.	.	.
cord-332109-ont0tqpn	420	1	WHO	who	WP
cord-332109-ont0tqpn	420	2	Director	Director	NNP
cord-332109-ont0tqpn	420	3	-	-	HYPH
cord-332109-ont0tqpn	420	4	General	General	NNP
cord-332109-ont0tqpn	420	5	's	's	POS
cord-332109-ont0tqpn	420	6	Opening	Opening	NNP
cord-332109-ont0tqpn	420	7	Remarks	Remarks	NNP
cord-332109-ont0tqpn	420	8	at	at	IN
cord-332109-ont0tqpn	420	9	the	the	DT
cord-332109-ont0tqpn	420	10	Media	Media	NNPS
cord-332109-ont0tqpn	420	11	Briefing	Briefing	NNP
cord-332109-ont0tqpn	420	12	on	on	IN
cord-332109-ont0tqpn	420	13	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	420	14	-	-	HYPH
cord-332109-ont0tqpn	420	15	11	11	CD
cord-332109-ont0tqpn	420	16	Substance	Substance	NNP
cord-332109-ont0tqpn	420	17	Abuse	Abuse	NNP
cord-332109-ont0tqpn	420	18	and	and	CC
cord-332109-ont0tqpn	420	19	Mental	Mental	NNP
cord-332109-ont0tqpn	420	20	Health	Health	NNP
cord-332109-ont0tqpn	420	21	Services	Services	NNPS
cord-332109-ont0tqpn	420	22	Administration	Administration	NNP
cord-332109-ont0tqpn	420	23	.	.	.
cord-332109-ont0tqpn	421	1	Key	key	JJ
cord-332109-ont0tqpn	421	2	Substance	substance	NN
cord-332109-ont0tqpn	421	3	Use	Use	NNP
cord-332109-ont0tqpn	421	4	and	and	CC
cord-332109-ont0tqpn	421	5	Mental	Mental	NNP
cord-332109-ont0tqpn	421	6	Health	Health	NNP
cord-332109-ont0tqpn	421	7	Indicators	Indicators	NNPS
cord-332109-ont0tqpn	421	8	in	in	IN
cord-332109-ont0tqpn	421	9	the	the	DT
cord-332109-ont0tqpn	421	10	United	United	NNP
cord-332109-ont0tqpn	421	11	States	States	NNP
cord-332109-ont0tqpn	421	12	:	:	:
cord-332109-ont0tqpn	421	13	Results	result	NNS
cord-332109-ont0tqpn	421	14	from	from	IN
cord-332109-ont0tqpn	421	15	the	the	DT
cord-332109-ont0tqpn	421	16	2018	2018	CD
cord-332109-ont0tqpn	421	17	National	National	NNP
cord-332109-ont0tqpn	421	18	Survey	Survey	NNP
cord-332109-ont0tqpn	421	19	on	on	IN
cord-332109-ont0tqpn	421	20	Drug	Drug	NNP
cord-332109-ont0tqpn	421	21	Use	Use	NNP
cord-332109-ont0tqpn	421	22	and	and	CC
cord-332109-ont0tqpn	421	23	Health	Health	NNP
cord-332109-ont0tqpn	421	24	Collision	Collision	NNP
cord-332109-ont0tqpn	421	25	of	of	IN
cord-332109-ont0tqpn	421	26	the	the	DT
cord-332109-ont0tqpn	421	27	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	421	28	and	and	CC
cord-332109-ont0tqpn	421	29	Addiction	Addiction	NNP
cord-332109-ont0tqpn	421	30	Epidemics	Epidemics	NNPS
cord-332109-ont0tqpn	421	31	Electronic	Electronic	NNP
cord-332109-ont0tqpn	421	32	cigarettes	cigarette	NNS
cord-332109-ont0tqpn	421	33	disrupt	disrupt	VBP
cord-332109-ont0tqpn	421	34	lung	lung	NN
cord-332109-ont0tqpn	421	35	lipid	lipid	NN
cord-332109-ont0tqpn	421	36	homeostasis	homeostasis	NN
cord-332109-ont0tqpn	421	37	and	and	CC
cord-332109-ont0tqpn	421	38	innate	innate	JJ
cord-332109-ont0tqpn	421	39	immunity	immunity	NN
cord-332109-ont0tqpn	421	40	independent	independent	JJ
cord-332109-ont0tqpn	421	41	of	of	IN
cord-332109-ont0tqpn	421	42	nicotine	nicotine	NN
cord-332109-ont0tqpn	421	43	Cigarette	Cigarette	NNP
cord-332109-ont0tqpn	421	44	smoke	smoke	NN
cord-332109-ont0tqpn	421	45	induces	induce	VBZ
cord-332109-ont0tqpn	421	46	distinct	distinct	JJ
cord-332109-ont0tqpn	421	47	histone	histone	NN
cord-332109-ont0tqpn	421	48	modifications	modification	NNS
cord-332109-ont0tqpn	421	49	in	in	IN
cord-332109-ont0tqpn	421	50	lung	lung	NN
cord-332109-ont0tqpn	421	51	cells	cell	NNS
cord-332109-ont0tqpn	421	52	:	:	:
cord-332109-ont0tqpn	421	53	Implications	implication	NNS
cord-332109-ont0tqpn	421	54	for	for	IN
cord-332109-ont0tqpn	421	55	the	the	DT
cord-332109-ont0tqpn	421	56	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	421	57	of	of	IN
cord-332109-ont0tqpn	421	58	COPD	COPD	NNP
cord-332109-ont0tqpn	421	59	and	and	CC
cord-332109-ont0tqpn	421	60	lung	lung	NN
cord-332109-ont0tqpn	421	61	cancer	cancer	NN
cord-332109-ont0tqpn	421	62	Effects	effect	NNS
cord-332109-ont0tqpn	421	63	of	of	IN
cord-332109-ont0tqpn	421	64	cannabis	cannabis	NN
cord-332109-ont0tqpn	421	65	on	on	IN
cord-332109-ont0tqpn	421	66	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	421	67	structure	structure	NN
cord-332109-ont0tqpn	421	68	,	,	,
cord-332109-ont0tqpn	421	69	function	function	NN
cord-332109-ont0tqpn	421	70	and	and	CC
cord-332109-ont0tqpn	421	71	symptoms	symptom	NNS
cord-332109-ont0tqpn	421	72	Characteristics	characteristic	NNS
cord-332109-ont0tqpn	421	73	of	of	IN
cord-332109-ont0tqpn	421	74	and	and	CC
cord-332109-ont0tqpn	421	75	Important	Important	NNP
cord-332109-ont0tqpn	421	76	Lessons	lesson	NNS
cord-332109-ont0tqpn	421	77	from	from	IN
cord-332109-ont0tqpn	421	78	the	the	DT
cord-332109-ont0tqpn	421	79	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	421	80	Disease	Disease	NNP
cord-332109-ont0tqpn	421	81	2019	2019	CD
cord-332109-ont0tqpn	421	82	(	(	-LRB-
cord-332109-ont0tqpn	421	83	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	421	84	)	)	-RRB-
cord-332109-ont0tqpn	421	85	Outbreak	outbreak	NN
cord-332109-ont0tqpn	421	86	in	in	IN
cord-332109-ont0tqpn	421	87	China	China	NNP
cord-332109-ont0tqpn	421	88	:	:	:
cord-332109-ont0tqpn	421	89	Summary	Summary	NNP
cord-332109-ont0tqpn	421	90	of	of	IN
cord-332109-ont0tqpn	421	91	a	a	DT
cord-332109-ont0tqpn	421	92	Report	Report	NNP
cord-332109-ont0tqpn	421	93	of	of	IN
cord-332109-ont0tqpn	421	94	72	72	CD
cord-332109-ont0tqpn	421	95	314	314	CD
cord-332109-ont0tqpn	421	96	Cases	case	NNS
cord-332109-ont0tqpn	421	97	From	from	IN
cord-332109-ont0tqpn	421	98	the	the	DT
cord-332109-ont0tqpn	421	99	Chinese	Chinese	NNP
cord-332109-ont0tqpn	421	100	Center	Center	NNP
cord-332109-ont0tqpn	421	101	for	for	IN
cord-332109-ont0tqpn	421	102	Disease	Disease	NNP
cord-332109-ont0tqpn	421	103	Control	Control	NNP
cord-332109-ont0tqpn	421	104	and	and	CC
cord-332109-ont0tqpn	421	105	Prevention	Prevention	NNP
cord-332109-ont0tqpn	421	106	Severity	Severity	NNP
cord-332109-ont0tqpn	421	107	and	and	CC
cord-332109-ont0tqpn	421	108	Mortality	Mortality	NNP
cord-332109-ont0tqpn	421	109	associated	associate	VBN
cord-332109-ont0tqpn	421	110	with	with	IN
cord-332109-ont0tqpn	421	111	COPD	COPD	NNP
cord-332109-ont0tqpn	421	112	and	and	CC
cord-332109-ont0tqpn	421	113	Smoking	smoking	NN
cord-332109-ont0tqpn	421	114	in	in	IN
cord-332109-ont0tqpn	421	115	patients	patient	NNS
cord-332109-ont0tqpn	421	116	with	with	IN
cord-332109-ont0tqpn	421	117	COVID-19	covid-19	NN
cord-332109-ont0tqpn	421	118	:	:	:
cord-332109-ont0tqpn	421	119	A	a	DT
cord-332109-ont0tqpn	421	120	Rapid	Rapid	NNP
cord-332109-ont0tqpn	421	121	Systematic	Systematic	NNP
cord-332109-ont0tqpn	421	122	Review	Review	NNP
cord-332109-ont0tqpn	421	123	and	and	CC
cord-332109-ont0tqpn	421	124	Meta	Meta	NNP
cord-332109-ont0tqpn	421	125	-	-	HYPH
cord-332109-ont0tqpn	421	126	Analysis	Analysis	NNP
cord-332109-ont0tqpn	422	1	An	an	DT
cord-332109-ont0tqpn	422	2	Epidemic	epidemic	NN
cord-332109-ont0tqpn	422	3	in	in	IN
cord-332109-ont0tqpn	422	4	the	the	DT
cord-332109-ont0tqpn	422	5	Midst	Midst	NNP
cord-332109-ont0tqpn	422	6	of	of	IN
cord-332109-ont0tqpn	422	7	a	a	DT
cord-332109-ont0tqpn	422	8	Pandemic	pandemic	NN
cord-332109-ont0tqpn	422	9	:	:	:
cord-332109-ont0tqpn	423	1	Opioid	opioid	NN
cord-332109-ont0tqpn	423	2	Use	Use	NNP
cord-332109-ont0tqpn	423	3	Disorder	Disorder	NNP
cord-332109-ont0tqpn	423	4	and	and	CC
cord-332109-ont0tqpn	423	5	COVID-19	covid-19	NN
cord-332109-ont0tqpn	424	1	When	when	WRB
cord-332109-ont0tqpn	424	2	Epidemics	epidemic	NNS
cord-332109-ont0tqpn	424	3	Collide	collide	VBP
cord-332109-ont0tqpn	424	4	:	:	:
cord-332109-ont0tqpn	424	5	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	424	6	Disease	Disease	NNP
cord-332109-ont0tqpn	424	7	2019	2019	CD
cord-332109-ont0tqpn	424	8	(	(	-LRB-
cord-332109-ont0tqpn	424	9	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	424	10	)	)	-RRB-
cord-332109-ont0tqpn	424	11	and	and	CC
cord-332109-ont0tqpn	424	12	the	the	DT
cord-332109-ont0tqpn	424	13	Opioid	Opioid	NNP
cord-332109-ont0tqpn	424	14	Crisis	Crisis	NNP
cord-332109-ont0tqpn	424	15	Clinical	Clinical	NNP
cord-332109-ont0tqpn	424	16	Characteristics	Characteristics	NNPS
cord-332109-ont0tqpn	424	17	and	and	CC
cord-332109-ont0tqpn	424	18	Outcome	outcome	NN
cord-332109-ont0tqpn	424	19	of	of	IN
cord-332109-ont0tqpn	424	20	Methamphetamine	Methamphetamine	NNP
cord-332109-ont0tqpn	424	21	-	-	HYPH
cord-332109-ont0tqpn	424	22	Associated	Associated	NNP
cord-332109-ont0tqpn	424	23	Pulmonary	Pulmonary	NNP
cord-332109-ont0tqpn	424	24	Arterial	arterial	JJ
cord-332109-ont0tqpn	424	25	Hypertension	hypertension	NN
cord-332109-ont0tqpn	424	26	and	and	CC
cord-332109-ont0tqpn	424	27	Dilated	dilate	VBN
cord-332109-ont0tqpn	424	28	Cardiomyopathy	Cardiomyopathy	NNP
cord-332109-ont0tqpn	424	29	Substance	substance	NN
cord-332109-ont0tqpn	425	1	use	use	VB
cord-332109-ont0tqpn	425	2	disorders	disorder	NNS
cord-332109-ont0tqpn	425	3	and	and	CC
cord-332109-ont0tqpn	425	4	risk	risk	NN
cord-332109-ont0tqpn	425	5	of	of	IN
cord-332109-ont0tqpn	425	6	suicide	suicide	NN
cord-332109-ont0tqpn	425	7	in	in	IN
cord-332109-ont0tqpn	425	8	a	a	DT
cord-332109-ont0tqpn	425	9	general	general	JJ
cord-332109-ont0tqpn	425	10	US	US	NNP
cord-332109-ont0tqpn	425	11	population	population	NN
cord-332109-ont0tqpn	425	12	:	:	:
cord-332109-ont0tqpn	426	1	A	a	DT
cord-332109-ont0tqpn	426	2	case	case	NN
cord-332109-ont0tqpn	426	3	control	control	NN
cord-332109-ont0tqpn	426	4	study	study	NN
cord-332109-ont0tqpn	426	5	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	426	6	and	and	CC
cord-332109-ont0tqpn	426	7	Substance	Substance	NNP
cord-332109-ont0tqpn	426	8	Use	Use	NNP
cord-332109-ont0tqpn	426	9	Disorders	disorder	NNS
cord-332109-ont0tqpn	426	10	:	:	:
cord-332109-ont0tqpn	427	1	Recommendations	recommendation	NNS
cord-332109-ont0tqpn	427	2	to	to	IN
cord-332109-ont0tqpn	427	3	a	a	DT
cord-332109-ont0tqpn	427	4	Comprehensive	Comprehensive	NNP
cord-332109-ont0tqpn	427	5	Healthcare	Healthcare	NNP
cord-332109-ont0tqpn	427	6	Response	Response	NNP
cord-332109-ont0tqpn	427	7	.	.	.
cord-332109-ont0tqpn	428	1	An	an	DT
cord-332109-ont0tqpn	428	2	International	International	NNP
cord-332109-ont0tqpn	428	3	Society	Society	NNP
cord-332109-ont0tqpn	428	4	of	of	IN
cord-332109-ont0tqpn	428	5	Addiction	Addiction	NNP
cord-332109-ont0tqpn	428	6	Medicine	Medicine	NNP
cord-332109-ont0tqpn	428	7	(	(	-LRB-
cord-332109-ont0tqpn	428	8	ISAM	ISAM	NNP
cord-332109-ont0tqpn	428	9	)	)	-RRB-
cord-332109-ont0tqpn	428	10	Practice	Practice	NNP
cord-332109-ont0tqpn	428	11	and	and	CC
cord-332109-ont0tqpn	428	12	Policy	Policy	NNP
cord-332109-ont0tqpn	428	13	Interest	Interest	NNP
cord-332109-ont0tqpn	428	14	Group	Group	NNP
cord-332109-ont0tqpn	428	15	Position	Position	NNP
cord-332109-ont0tqpn	428	16	Paper	Paper	NNP
cord-332109-ont0tqpn	428	17	Origin	Origin	NNP
cord-332109-ont0tqpn	428	18	and	and	CC
cord-332109-ont0tqpn	428	19	evolution	evolution	NN
cord-332109-ont0tqpn	428	20	of	of	IN
cord-332109-ont0tqpn	428	21	pathogenic	pathogenic	JJ
cord-332109-ont0tqpn	428	22	coronaviruses	coronaviruse	NNS
cord-332109-ont0tqpn	429	1	A	a	DT
cord-332109-ont0tqpn	429	2	pneumonia	pneumonia	NN
cord-332109-ont0tqpn	429	3	outbreak	outbreak	NN
cord-332109-ont0tqpn	429	4	associated	associate	VBN
cord-332109-ont0tqpn	429	5	with	with	IN
cord-332109-ont0tqpn	429	6	a	a	DT
cord-332109-ont0tqpn	429	7	new	new	JJ
cord-332109-ont0tqpn	429	8	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	429	9	of	of	IN
cord-332109-ont0tqpn	429	10	probable	probable	JJ
cord-332109-ont0tqpn	429	11	bat	bat	NN
cord-332109-ont0tqpn	429	12	origin	origin	NN
cord-332109-ont0tqpn	430	1	A	a	DT
cord-332109-ont0tqpn	430	2	new	new	JJ
cord-332109-ont0tqpn	430	3	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	430	4	associated	associate	VBN
cord-332109-ont0tqpn	430	5	with	with	IN
cord-332109-ont0tqpn	430	6	human	human	JJ
cord-332109-ont0tqpn	430	7	respiratory	respiratory	JJ
cord-332109-ont0tqpn	430	8	disease	disease	NN
cord-332109-ont0tqpn	430	9	in	in	IN
cord-332109-ont0tqpn	430	10	China	China	NNP
cord-332109-ont0tqpn	430	11	Functional	functional	JJ
cord-332109-ont0tqpn	430	12	assessment	assessment	NN
cord-332109-ont0tqpn	430	13	of	of	IN
cord-332109-ont0tqpn	430	14	cell	cell	NN
cord-332109-ont0tqpn	430	15	entry	entry	NN
cord-332109-ont0tqpn	430	16	and	and	CC
cord-332109-ont0tqpn	430	17	receptor	receptor	NN
cord-332109-ont0tqpn	430	18	usage	usage	NN
cord-332109-ont0tqpn	430	19	for	for	IN
cord-332109-ont0tqpn	430	20	SARS	SARS	NNP
cord-332109-ont0tqpn	430	21	-	-	HYPH
cord-332109-ont0tqpn	430	22	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	430	23	and	and	CC
cord-332109-ont0tqpn	430	24	other	other	JJ
cord-332109-ont0tqpn	430	25	lineage	lineage	NN
cord-332109-ont0tqpn	430	26	B	b	NN
cord-332109-ont0tqpn	430	27	betacoronaviruses	betacoronaviruses	NNP
cord-332109-ont0tqpn	430	28	Cryo	Cryo	NNP
cord-332109-ont0tqpn	430	29	-	-	HYPH
cord-332109-ont0tqpn	430	30	EM	EM	NNP
cord-332109-ont0tqpn	430	31	structure	structure	NN
cord-332109-ont0tqpn	430	32	of	of	IN
cord-332109-ont0tqpn	430	33	the	the	DT
cord-332109-ont0tqpn	430	34	2019-nCoV	2019-ncov	CD
cord-332109-ont0tqpn	430	35	spike	spike	NN
cord-332109-ont0tqpn	430	36	in	in	IN
cord-332109-ont0tqpn	430	37	the	the	DT
cord-332109-ont0tqpn	430	38	prefusion	prefusion	NN
cord-332109-ont0tqpn	430	39	conformation	conformation	NN
cord-332109-ont0tqpn	430	40	Structure	Structure	NNP
cord-332109-ont0tqpn	430	41	,	,	,
cord-332109-ont0tqpn	430	42	Function	Function	NNP
cord-332109-ont0tqpn	430	43	,	,	,
cord-332109-ont0tqpn	430	44	and	and	CC
cord-332109-ont0tqpn	430	45	Antigenicity	Antigenicity	NNP
cord-332109-ont0tqpn	430	46	of	of	IN
cord-332109-ont0tqpn	430	47	the	the	DT
cord-332109-ont0tqpn	430	48	SARS	SARS	NNP
cord-332109-ont0tqpn	430	49	-	-	HYPH
cord-332109-ont0tqpn	430	50	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	430	51	Spike	Spike	NNP
cord-332109-ont0tqpn	430	52	Glycoprotein	Glycoprotein	NNP
cord-332109-ont0tqpn	430	53	Characterization	characterization	NN
cord-332109-ont0tqpn	430	54	of	of	IN
cord-332109-ont0tqpn	430	55	the	the	DT
cord-332109-ont0tqpn	430	56	receptor	receptor	NN
cord-332109-ont0tqpn	430	57	-	-	HYPH
cord-332109-ont0tqpn	430	58	binding	bind	VBG
cord-332109-ont0tqpn	430	59	domain	domain	NN
cord-332109-ont0tqpn	430	60	(	(	-LRB-
cord-332109-ont0tqpn	430	61	RBD	RBD	NNP
cord-332109-ont0tqpn	430	62	)	)	-RRB-
cord-332109-ont0tqpn	430	63	of	of	IN
cord-332109-ont0tqpn	430	64	2019	2019	CD
cord-332109-ont0tqpn	430	65	novel	novel	NN
cord-332109-ont0tqpn	430	66	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	430	67	:	:	:
cord-332109-ont0tqpn	430	68	Implication	implication	NN
cord-332109-ont0tqpn	430	69	for	for	IN
cord-332109-ont0tqpn	430	70	development	development	NN
cord-332109-ont0tqpn	430	71	of	of	IN
cord-332109-ont0tqpn	430	72	RBD	RBD	NNP
cord-332109-ont0tqpn	430	73	protein	protein	NN
cord-332109-ont0tqpn	430	74	as	as	IN
cord-332109-ont0tqpn	430	75	a	a	DT
cord-332109-ont0tqpn	430	76	viral	viral	JJ
cord-332109-ont0tqpn	430	77	attachment	attachment	NN
cord-332109-ont0tqpn	430	78	inhibitor	inhibitor	NN
cord-332109-ont0tqpn	430	79	and	and	CC
cord-332109-ont0tqpn	430	80	vaccine	vaccine	NN
cord-332109-ont0tqpn	430	81	Emerging	Emerging	NNP
cord-332109-ont0tqpn	430	82	WuHan	WuHan	NNP
cord-332109-ont0tqpn	430	83	(	(	-LRB-
cord-332109-ont0tqpn	430	84	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	430	85	)	)	-RRB-
cord-332109-ont0tqpn	430	86	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	430	87	:	:	:
cord-332109-ont0tqpn	430	88	Glycan	glycan	JJ
cord-332109-ont0tqpn	430	89	shield	shield	NN
cord-332109-ont0tqpn	430	90	and	and	CC
cord-332109-ont0tqpn	430	91	structure	structure	NN
cord-332109-ont0tqpn	430	92	prediction	prediction	NN
cord-332109-ont0tqpn	430	93	of	of	IN
cord-332109-ont0tqpn	430	94	spike	spike	NN
cord-332109-ont0tqpn	430	95	glycoprotein	glycoprotein	NN
cord-332109-ont0tqpn	430	96	and	and	CC
cord-332109-ont0tqpn	430	97	its	-PRON-	PRP$
cord-332109-ont0tqpn	430	98	interaction	interaction	NN
cord-332109-ont0tqpn	430	99	with	with	IN
cord-332109-ont0tqpn	430	100	human	human	JJ
cord-332109-ont0tqpn	430	101	CD26	CD26	NNP
cord-332109-ont0tqpn	430	102	Site	site	NN
cord-332109-ont0tqpn	430	103	-	-	HYPH
cord-332109-ont0tqpn	430	104	specific	specific	JJ
cord-332109-ont0tqpn	430	105	glycan	glycan	NN
cord-332109-ont0tqpn	430	106	analysis	analysis	NN
cord-332109-ont0tqpn	430	107	of	of	IN
cord-332109-ont0tqpn	430	108	the	the	DT
cord-332109-ont0tqpn	430	109	SARS	SARS	NNP
cord-332109-ont0tqpn	430	110	-	-	HYPH
cord-332109-ont0tqpn	430	111	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	430	112	spike	spike	NN
cord-332109-ont0tqpn	430	113	SARS	SARS	NNP
cord-332109-ont0tqpn	430	114	-	-	HYPH
cord-332109-ont0tqpn	430	115	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	430	116	Cell	Cell	NNP
cord-332109-ont0tqpn	430	117	Entry	entry	NN
cord-332109-ont0tqpn	430	118	Depends	depend	VBZ
cord-332109-ont0tqpn	430	119	on	on	IN
cord-332109-ont0tqpn	430	120	ACE2	ACE2	NNP
cord-332109-ont0tqpn	430	121	and	and	CC
cord-332109-ont0tqpn	430	122	TMPRSS2	TMPRSS2	NNP
cord-332109-ont0tqpn	430	123	and	and	CC
cord-332109-ont0tqpn	430	124	Is	be	VBZ
cord-332109-ont0tqpn	430	125	Blocked	block	VBN
cord-332109-ont0tqpn	430	126	by	by	IN
cord-332109-ont0tqpn	430	127	a	a	DT
cord-332109-ont0tqpn	430	128	Clinically	clinically	RB
cord-332109-ont0tqpn	430	129	Proven	prove	VBN
cord-332109-ont0tqpn	430	130	Protease	protease	NN
cord-332109-ont0tqpn	430	131	Inhibitor	Inhibitor	NNP
cord-332109-ont0tqpn	430	132	SARS	SARS	NNP
cord-332109-ont0tqpn	430	133	-	-	HYPH
cord-332109-ont0tqpn	430	134	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	430	135	entry	entry	NN
cord-332109-ont0tqpn	430	136	factors	factor	NNS
cord-332109-ont0tqpn	430	137	are	be	VBP
cord-332109-ont0tqpn	430	138	highly	highly	RB
cord-332109-ont0tqpn	430	139	expressed	express	VBN
cord-332109-ont0tqpn	430	140	in	in	IN
cord-332109-ont0tqpn	430	141	nasal	nasal	JJ
cord-332109-ont0tqpn	430	142	epithelial	epithelial	JJ
cord-332109-ont0tqpn	430	143	cells	cell	NNS
cord-332109-ont0tqpn	430	144	together	together	RB
cord-332109-ont0tqpn	430	145	with	with	IN
cord-332109-ont0tqpn	430	146	innate	innate	JJ
cord-332109-ont0tqpn	430	147	immune	immune	JJ
cord-332109-ont0tqpn	430	148	genes	gene	NNS
cord-332109-ont0tqpn	431	1	Molecular	molecular	JJ
cord-332109-ont0tqpn	431	2	immune	immune	JJ
cord-332109-ont0tqpn	431	3	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	431	4	and	and	CC
cord-332109-ont0tqpn	431	5	diagnosis	diagnosis	NN
cord-332109-ont0tqpn	431	6	of	of	IN
cord-332109-ont0tqpn	431	7	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	431	8	Structural	structural	JJ
cord-332109-ont0tqpn	431	9	basis	basis	NN
cord-332109-ont0tqpn	431	10	for	for	IN
cord-332109-ont0tqpn	431	11	translational	translational	JJ
cord-332109-ont0tqpn	431	12	shutdown	shutdown	NN
cord-332109-ont0tqpn	431	13	and	and	CC
cord-332109-ont0tqpn	431	14	immune	immune	JJ
cord-332109-ont0tqpn	431	15	evasion	evasion	NN
cord-332109-ont0tqpn	431	16	by	by	IN
cord-332109-ont0tqpn	431	17	the	the	DT
cord-332109-ont0tqpn	431	18	Nsp1	Nsp1	NNP
cord-332109-ont0tqpn	431	19	protein	protein	NN
cord-332109-ont0tqpn	431	20	of	of	IN
cord-332109-ont0tqpn	431	21	SARS	SARS	NNP
cord-332109-ont0tqpn	431	22	-	-	HYPH
cord-332109-ont0tqpn	431	23	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	431	24	Structural	Structural	NNP
cord-332109-ont0tqpn	431	25	Genomics	Genomics	NNPS
cord-332109-ont0tqpn	431	26	of	of	IN
cord-332109-ont0tqpn	431	27	SARS	SARS	NNP
cord-332109-ont0tqpn	431	28	-	-	HYPH
cord-332109-ont0tqpn	431	29	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	431	30	Indicates	indicate	VBZ
cord-332109-ont0tqpn	431	31	Evolutionary	Evolutionary	NNP
cord-332109-ont0tqpn	431	32	Conserved	conserved	JJ
cord-332109-ont0tqpn	431	33	Functional	functional	JJ
cord-332109-ont0tqpn	431	34	Regions	region	NNS
cord-332109-ont0tqpn	431	35	of	of	IN
cord-332109-ont0tqpn	431	36	Viral	Viral	NNP
cord-332109-ont0tqpn	431	37	Proteins	Proteins	NNPS
cord-332109-ont0tqpn	431	38	Emergence	Emergence	NNP
cord-332109-ont0tqpn	431	39	of	of	IN
cord-332109-ont0tqpn	431	40	genomic	genomic	JJ
cord-332109-ont0tqpn	431	41	diversity	diversity	NN
cord-332109-ont0tqpn	431	42	and	and	CC
cord-332109-ont0tqpn	431	43	recurrent	recurrent	JJ
cord-332109-ont0tqpn	431	44	mutations	mutation	NNS
cord-332109-ont0tqpn	431	45	in	in	IN
cord-332109-ont0tqpn	431	46	SARS	SARS	NNP
cord-332109-ont0tqpn	431	47	-	-	HYPH
cord-332109-ont0tqpn	431	48	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	432	1	The	the	DT
cord-332109-ont0tqpn	432	2	D614	d614	NN
cord-332109-ont0tqpn	432	3	G	g	NN
cord-332109-ont0tqpn	432	4	mutation	mutation	NN
cord-332109-ont0tqpn	432	5	of	of	IN
cord-332109-ont0tqpn	432	6	SARS	SARS	NNP
cord-332109-ont0tqpn	432	7	-	-	HYPH
cord-332109-ont0tqpn	432	8	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	432	9	spike	spike	NN
cord-332109-ont0tqpn	432	10	protein	protein	NN
cord-332109-ont0tqpn	432	11	enhances	enhance	VBZ
cord-332109-ont0tqpn	432	12	viral	viral	JJ
cord-332109-ont0tqpn	432	13	infectivity	infectivity	NN
cord-332109-ont0tqpn	432	14	and	and	CC
cord-332109-ont0tqpn	432	15	decreases	decrease	VBZ
cord-332109-ont0tqpn	432	16	neutralization	neutralization	NN
cord-332109-ont0tqpn	432	17	sensitivity	sensitivity	NN
cord-332109-ont0tqpn	432	18	to	to	IN
cord-332109-ont0tqpn	432	19	individual	individual	JJ
cord-332109-ont0tqpn	432	20	convalescent	convalescent	NN
cord-332109-ont0tqpn	432	21	sera	sera	NNP
cord-332109-ont0tqpn	433	1	The	the	DT
cord-332109-ont0tqpn	433	2	D614	d614	NN
cord-332109-ont0tqpn	433	3	G	g	NN
cord-332109-ont0tqpn	433	4	mutation	mutation	NN
cord-332109-ont0tqpn	433	5	in	in	IN
cord-332109-ont0tqpn	433	6	the	the	DT
cord-332109-ont0tqpn	433	7	SARS	SARS	NNP
cord-332109-ont0tqpn	433	8	-	-	HYPH
cord-332109-ont0tqpn	433	9	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	433	10	spike	spike	NN
cord-332109-ont0tqpn	433	11	protein	protein	NN
cord-332109-ont0tqpn	433	12	reduces	reduce	VBZ
cord-332109-ont0tqpn	433	13	S1	s1	NN
cord-332109-ont0tqpn	433	14	shedding	shedding	NN
cord-332109-ont0tqpn	433	15	and	and	CC
cord-332109-ont0tqpn	433	16	increases	increase	VBZ
cord-332109-ont0tqpn	433	17	infectivity	infectivity	NN
cord-332109-ont0tqpn	433	18	Spike	spike	NN
cord-332109-ont0tqpn	433	19	mutation	mutation	NN
cord-332109-ont0tqpn	433	20	pipeline	pipeline	NN
cord-332109-ont0tqpn	433	21	reveals	reveal	VBZ
cord-332109-ont0tqpn	433	22	the	the	DT
cord-332109-ont0tqpn	433	23	emergence	emergence	NN
cord-332109-ont0tqpn	433	24	of	of	IN
cord-332109-ont0tqpn	433	25	a	a	DT
cord-332109-ont0tqpn	433	26	more	more	RBR
cord-332109-ont0tqpn	433	27	transmissible	transmissible	JJ
cord-332109-ont0tqpn	433	28	form	form	NN
cord-332109-ont0tqpn	433	29	of	of	IN
cord-332109-ont0tqpn	433	30	SARS	SARS	NNP
cord-332109-ont0tqpn	433	31	-	-	HYPH
cord-332109-ont0tqpn	433	32	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	433	33	Factors	factor	NNS
cord-332109-ont0tqpn	433	34	associated	associate	VBN
cord-332109-ont0tqpn	433	35	with	with	IN
cord-332109-ont0tqpn	433	36	hospitalization	hospitalization	NN
cord-332109-ont0tqpn	433	37	and	and	CC
cord-332109-ont0tqpn	433	38	critical	critical	JJ
cord-332109-ont0tqpn	433	39	illness	illness	NN
cord-332109-ont0tqpn	433	40	among	among	IN
cord-332109-ont0tqpn	433	41	4103	4103	CD
cord-332109-ont0tqpn	433	42	patients	patient	NNS
cord-332109-ont0tqpn	433	43	with	with	IN
cord-332109-ont0tqpn	433	44	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	433	45	disease	disease	NN
cord-332109-ont0tqpn	433	46	Effect	effect	NN
cord-332109-ont0tqpn	433	47	of	of	IN
cord-332109-ont0tqpn	433	48	Underlying	Underlying	NNP
cord-332109-ont0tqpn	433	49	Comorbidities	Comorbidities	NNPS
cord-332109-ont0tqpn	433	50	on	on	IN
cord-332109-ont0tqpn	433	51	the	the	DT
cord-332109-ont0tqpn	433	52	Infection	Infection	NNP
cord-332109-ont0tqpn	433	53	and	and	CC
cord-332109-ont0tqpn	433	54	Severity	severity	NN
cord-332109-ont0tqpn	433	55	of	of	IN
cord-332109-ont0tqpn	433	56	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	433	57	in	in	IN
cord-332109-ont0tqpn	433	58	Korea	Korea	NNP
cord-332109-ont0tqpn	433	59	:	:	:
cord-332109-ont0tqpn	434	1	A	a	DT
cord-332109-ont0tqpn	434	2	Nationwide	Nationwide	NNP
cord-332109-ont0tqpn	434	3	Case	Case	NNP
cord-332109-ont0tqpn	434	4	-	-	HYPH
cord-332109-ont0tqpn	434	5	Control	Control	NNP
cord-332109-ont0tqpn	434	6	Study	Study	NNP
cord-332109-ont0tqpn	434	7	Overdose	overdose	NN
cord-332109-ont0tqpn	434	8	and	and	CC
cord-332109-ont0tqpn	434	9	risk	risk	NN
cord-332109-ont0tqpn	434	10	factors	factor	NNS
cord-332109-ont0tqpn	434	11	for	for	IN
cord-332109-ont0tqpn	434	12	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	434	13	disease	disease	NN
cord-332109-ont0tqpn	434	14	2019	2019	CD
cord-332109-ont0tqpn	434	15	Alcohol	Alcohol	NNP
cord-332109-ont0tqpn	434	16	use	use	NN
cord-332109-ont0tqpn	434	17	and	and	CC
cord-332109-ont0tqpn	434	18	misuse	misuse	NN
cord-332109-ont0tqpn	434	19	during	during	IN
cord-332109-ont0tqpn	434	20	the	the	DT
cord-332109-ont0tqpn	434	21	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	434	22	pandemic	pandemic	NN
cord-332109-ont0tqpn	434	23	:	:	:
cord-332109-ont0tqpn	434	24	A	a	DT
cord-332109-ont0tqpn	434	25	potential	potential	JJ
cord-332109-ont0tqpn	434	26	public	public	JJ
cord-332109-ont0tqpn	434	27	health	health	NN
cord-332109-ont0tqpn	434	28	crisis	crisis	NN
cord-332109-ont0tqpn	434	29	?	?	.
cord-332109-ont0tqpn	435	1	Lancet	Lancet	NNP
cord-332109-ont0tqpn	435	2	Public	Public	NNP
cord-332109-ont0tqpn	435	3	Health	Health	NNP
cord-332109-ont0tqpn	435	4	Report	Report	NNP
cord-332109-ont0tqpn	435	5	:	:	:
cord-332109-ont0tqpn	435	6	Increased	Increased	NNP
cord-332109-ont0tqpn	435	7	Addictive	addictive	JJ
cord-332109-ont0tqpn	435	8	Internet	internet	NN
cord-332109-ont0tqpn	435	9	and	and	CC
cord-332109-ont0tqpn	435	10	Substance	Substance	NNP
cord-332109-ont0tqpn	435	11	Use	Use	NNP
cord-332109-ont0tqpn	435	12	Behavior	Behavior	NNP
cord-332109-ont0tqpn	436	1	During	during	IN
cord-332109-ont0tqpn	436	2	the	the	DT
cord-332109-ont0tqpn	436	3	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	436	4	Pandemic	Pandemic	NNP
cord-332109-ont0tqpn	436	5	in	in	IN
cord-332109-ont0tqpn	436	6	China	China	NNP
cord-332109-ont0tqpn	437	1	COVID-19	covid-19	VB
cord-332109-ont0tqpn	438	1	:	:	:
cord-332109-ont0tqpn	438	2	Towards	towards	IN
cord-332109-ont0tqpn	438	3	understanding	understanding	NN
cord-332109-ont0tqpn	438	4	of	of	IN
cord-332109-ont0tqpn	438	5	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	438	6	SARS	SARS	NNP
cord-332109-ont0tqpn	438	7	-	-	HYPH
cord-332109-ont0tqpn	438	8	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	438	9	Receptor	Receptor	NNP
cord-332109-ont0tqpn	438	10	ACE2	ACE2	NNP
cord-332109-ont0tqpn	438	11	Is	be	VBZ
cord-332109-ont0tqpn	438	12	an	an	DT
cord-332109-ont0tqpn	438	13	Interferon	Interferon	NNP
cord-332109-ont0tqpn	438	14	-	-	HYPH
cord-332109-ont0tqpn	438	15	Stimulated	stimulate	VBN
cord-332109-ont0tqpn	438	16	Gene	Gene	NNP
cord-332109-ont0tqpn	438	17	in	in	IN
cord-332109-ont0tqpn	438	18	Human	Human	NNP
cord-332109-ont0tqpn	438	19	Airway	Airway	NNP
cord-332109-ont0tqpn	438	20	Epithelial	Epithelial	NNP
cord-332109-ont0tqpn	438	21	Cells	cell	NNS
cord-332109-ont0tqpn	438	22	and	and	CC
cord-332109-ont0tqpn	438	23	Is	be	VBZ
cord-332109-ont0tqpn	438	24	Detected	detect	VBN
cord-332109-ont0tqpn	438	25	in	in	IN
cord-332109-ont0tqpn	438	26	Specific	specific	JJ
cord-332109-ont0tqpn	438	27	Cell	cell	NN
cord-332109-ont0tqpn	438	28	Subsets	subset	NNS
cord-332109-ont0tqpn	438	29	across	across	IN
cord-332109-ont0tqpn	438	30	Tissues	Tissues	NNPS
cord-332109-ont0tqpn	438	31	Single	single	JJ
cord-332109-ont0tqpn	438	32	-	-	HYPH
cord-332109-ont0tqpn	438	33	cell	cell	NN
cord-332109-ont0tqpn	438	34	longitudinal	longitudinal	JJ
cord-332109-ont0tqpn	438	35	analysis	analysis	NN
cord-332109-ont0tqpn	438	36	of	of	IN
cord-332109-ont0tqpn	438	37	SARS	SARS	NNP
cord-332109-ont0tqpn	438	38	-	-	HYPH
cord-332109-ont0tqpn	438	39	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	438	40	infection	infection	NN
cord-332109-ont0tqpn	438	41	in	in	IN
cord-332109-ont0tqpn	438	42	human	human	JJ
cord-332109-ont0tqpn	438	43	bronchial	bronchial	JJ
cord-332109-ont0tqpn	438	44	epithelial	epithelial	JJ
cord-332109-ont0tqpn	438	45	cells	cell	NNS
cord-332109-ont0tqpn	438	46	Tissue	tissue	NN
cord-332109-ont0tqpn	438	47	distribution	distribution	NN
cord-332109-ont0tqpn	438	48	of	of	IN
cord-332109-ont0tqpn	438	49	ACE2	ACE2	NNP
cord-332109-ont0tqpn	438	50	protein	protein	NN
cord-332109-ont0tqpn	438	51	,	,	,
cord-332109-ont0tqpn	438	52	the	the	DT
cord-332109-ont0tqpn	438	53	functional	functional	JJ
cord-332109-ont0tqpn	438	54	receptor	receptor	NN
cord-332109-ont0tqpn	438	55	for	for	IN
cord-332109-ont0tqpn	438	56	SARS	SARS	NNP
cord-332109-ont0tqpn	438	57	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	438	58	.	.	.
cord-332109-ont0tqpn	439	1	A	a	DT
cord-332109-ont0tqpn	439	2	first	first	JJ
cord-332109-ont0tqpn	439	3	step	step	NN
cord-332109-ont0tqpn	439	4	in	in	IN
cord-332109-ont0tqpn	439	5	understanding	understand	VBG
cord-332109-ont0tqpn	439	6	SARS	SARS	NNP
cord-332109-ont0tqpn	439	7	pathogenesis	pathogenesis	NN
cord-332109-ont0tqpn	439	8	Endothelial	endothelial	JJ
cord-332109-ont0tqpn	439	9	cell	cell	NN
cord-332109-ont0tqpn	439	10	infection	infection	NN
cord-332109-ont0tqpn	439	11	and	and	CC
cord-332109-ont0tqpn	439	12	endotheliitis	endotheliitis	NN
cord-332109-ont0tqpn	439	13	in	in	IN
cord-332109-ont0tqpn	439	14	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	439	15	Pulmonary	Pulmonary	NNP
cord-332109-ont0tqpn	439	16	Vascular	Vascular	NNP
cord-332109-ont0tqpn	439	17	Endothelialitis	Endothelialitis	NNP
cord-332109-ont0tqpn	439	18	,	,	,
cord-332109-ont0tqpn	439	19	Thrombosis	Thrombosis	NNP
cord-332109-ont0tqpn	439	20	,	,	,
cord-332109-ont0tqpn	439	21	and	and	CC
cord-332109-ont0tqpn	439	22	Angiogenesis	Angiogenesis	NNP
cord-332109-ont0tqpn	439	23	in	in	IN
cord-332109-ont0tqpn	440	1	Covid-19	covid-19	VB
cord-332109-ont0tqpn	440	2	You	-PRON-	PRP
cord-332109-ont0tqpn	440	3	Shall	Shall	NNP
cord-332109-ont0tqpn	441	1	Not	not	RB
cord-332109-ont0tqpn	441	2	Pass"-tight	pass"-tight	JJ
cord-332109-ont0tqpn	441	3	junctions	junction	NNS
cord-332109-ont0tqpn	441	4	of	of	IN
cord-332109-ont0tqpn	441	5	the	the	DT
cord-332109-ont0tqpn	441	6	blood	blood	NN
cord-332109-ont0tqpn	441	7	brain	brain	NN
cord-332109-ont0tqpn	441	8	barrier	barrier	NN
cord-332109-ont0tqpn	441	9	Tight	tight	JJ
cord-332109-ont0tqpn	441	10	junctions	junction	NNS
cord-332109-ont0tqpn	441	11	at	at	IN
cord-332109-ont0tqpn	441	12	the	the	DT
cord-332109-ont0tqpn	441	13	blood	blood	NN
cord-332109-ont0tqpn	441	14	brain	brain	NN
cord-332109-ont0tqpn	441	15	barrier	barrier	NN
cord-332109-ont0tqpn	441	16	:	:	:
cord-332109-ont0tqpn	441	17	Physiological	physiological	JJ
cord-332109-ont0tqpn	441	18	architecture	architecture	NN
cord-332109-ont0tqpn	441	19	and	and	CC
cord-332109-ont0tqpn	441	20	disease	disease	NN
cord-332109-ont0tqpn	441	21	-	-	HYPH
cord-332109-ont0tqpn	441	22	associated	associate	VBN
cord-332109-ont0tqpn	441	23	dysregulation	dysregulation	NN
cord-332109-ont0tqpn	441	24	Drug	drug	NN
cord-332109-ont0tqpn	441	25	resistance	resistance	NN
cord-332109-ont0tqpn	441	26	in	in	IN
cord-332109-ont0tqpn	441	27	brain	brain	NN
cord-332109-ont0tqpn	441	28	diseases	disease	NNS
cord-332109-ont0tqpn	441	29	and	and	CC
cord-332109-ont0tqpn	441	30	the	the	DT
cord-332109-ont0tqpn	441	31	role	role	NN
cord-332109-ont0tqpn	441	32	of	of	IN
cord-332109-ont0tqpn	441	33	drug	drug	NN
cord-332109-ont0tqpn	441	34	efflux	efflux	NN
cord-332109-ont0tqpn	441	35	transporters	transporter	NNS
cord-332109-ont0tqpn	441	36	Signaling	signal	VBG
cord-332109-ont0tqpn	441	37	pathways	pathway	NNS
cord-332109-ont0tqpn	441	38	that	that	WDT
cord-332109-ont0tqpn	441	39	regulate	regulate	VBP
cord-332109-ont0tqpn	441	40	basal	basal	JJ
cord-332109-ont0tqpn	441	41	ABC	ABC	NNP
cord-332109-ont0tqpn	441	42	transporter	transporter	NN
cord-332109-ont0tqpn	441	43	activity	activity	NN
cord-332109-ont0tqpn	441	44	at	at	IN
cord-332109-ont0tqpn	441	45	the	the	DT
cord-332109-ont0tqpn	441	46	blood	blood	NN
cord-332109-ont0tqpn	441	47	-	-	HYPH
cord-332109-ont0tqpn	441	48	brain	brain	NN
cord-332109-ont0tqpn	441	49	barrier	barrier	NN
cord-332109-ont0tqpn	441	50	Junctional	Junctional	NNP
cord-332109-ont0tqpn	441	51	proteins	protein	NNS
cord-332109-ont0tqpn	441	52	of	of	IN
cord-332109-ont0tqpn	441	53	the	the	DT
cord-332109-ont0tqpn	441	54	blood	blood	NN
cord-332109-ont0tqpn	441	55	-	-	HYPH
cord-332109-ont0tqpn	441	56	brain	brain	NN
cord-332109-ont0tqpn	441	57	barrier	barrier	NN
cord-332109-ont0tqpn	441	58	:	:	:
cord-332109-ont0tqpn	442	1	New	new	JJ
cord-332109-ont0tqpn	442	2	insights	insight	NNS
cord-332109-ont0tqpn	442	3	into	into	IN
cord-332109-ont0tqpn	442	4	function	function	NN
cord-332109-ont0tqpn	442	5	and	and	CC
cord-332109-ont0tqpn	442	6	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	442	7	Evidence	evidence	NN
cord-332109-ont0tqpn	442	8	of	of	IN
cord-332109-ont0tqpn	442	9	the	the	DT
cord-332109-ont0tqpn	442	10	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	442	11	Virus	Virus	NNP
cord-332109-ont0tqpn	442	12	Targeting	target	VBG
cord-332109-ont0tqpn	442	13	the	the	DT
cord-332109-ont0tqpn	442	14	CNS	CNS	NNP
cord-332109-ont0tqpn	442	15	:	:	:
cord-332109-ont0tqpn	442	16	Tissue	tissue	NN
cord-332109-ont0tqpn	442	17	Distribution	distribution	NN
cord-332109-ont0tqpn	442	18	,	,	,
cord-332109-ont0tqpn	442	19	Host	Host	NNP
cord-332109-ont0tqpn	442	20	-	-	HYPH
cord-332109-ont0tqpn	442	21	Virus	Virus	NNP
cord-332109-ont0tqpn	442	22	Interaction	Interaction	NNP
cord-332109-ont0tqpn	442	23	,	,	,
cord-332109-ont0tqpn	442	24	and	and	CC
cord-332109-ont0tqpn	442	25	Proposed	propose	VBN
cord-332109-ont0tqpn	442	26	Neurotropic	Neurotropic	NNP
cord-332109-ont0tqpn	442	27	Mechanisms	Mechanisms	NNPS
cord-332109-ont0tqpn	443	1	The	the	DT
cord-332109-ont0tqpn	443	2	neuroinvasive	neuroinvasive	JJ
cord-332109-ont0tqpn	443	3	potential	potential	NN
cord-332109-ont0tqpn	443	4	of	of	IN
cord-332109-ont0tqpn	443	5	SARS	SARS	NNP
cord-332109-ont0tqpn	443	6	-	-	HYPH
cord-332109-ont0tqpn	443	7	CoV2	CoV2	NNP
cord-332109-ont0tqpn	443	8	may	may	MD
cord-332109-ont0tqpn	443	9	play	play	VB
cord-332109-ont0tqpn	443	10	a	a	DT
cord-332109-ont0tqpn	443	11	role	role	NN
cord-332109-ont0tqpn	443	12	in	in	IN
cord-332109-ont0tqpn	443	13	the	the	DT
cord-332109-ont0tqpn	443	14	respiratory	respiratory	JJ
cord-332109-ont0tqpn	443	15	failure	failure	NN
cord-332109-ont0tqpn	443	16	of	of	IN
cord-332109-ont0tqpn	443	17	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	443	18	patients	patient	NNS
cord-332109-ont0tqpn	443	19	A	a	DT
cord-332109-ont0tqpn	443	20	first	first	JJ
cord-332109-ont0tqpn	443	21	case	case	NN
cord-332109-ont0tqpn	443	22	of	of	IN
cord-332109-ont0tqpn	443	23	meningitis	meningitis	NN
cord-332109-ont0tqpn	443	24	/	/	SYM
cord-332109-ont0tqpn	443	25	encephalitis	encephalitis	NN
cord-332109-ont0tqpn	443	26	associated	associate	VBN
cord-332109-ont0tqpn	443	27	with	with	IN
cord-332109-ont0tqpn	443	28	SARS	SARS	NNP
cord-332109-ont0tqpn	443	29	-	-	HYPH
cord-332109-ont0tqpn	443	30	Coronavirus-2	Coronavirus-2	NNP
cord-332109-ont0tqpn	443	31	Involvement	Involvement	NNP
cord-332109-ont0tqpn	443	32	of	of	IN
cord-332109-ont0tqpn	443	33	the	the	DT
cord-332109-ont0tqpn	443	34	Nervous	Nervous	NNP
cord-332109-ont0tqpn	443	35	System	System	NNP
cord-332109-ont0tqpn	443	36	in	in	IN
cord-332109-ont0tqpn	443	37	SARS	SARS	NNP
cord-332109-ont0tqpn	443	38	-	-	HYPH
cord-332109-ont0tqpn	443	39	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	443	40	Infection	infection	NN
cord-332109-ont0tqpn	443	41	Neurologic	Neurologic	NNP
cord-332109-ont0tqpn	443	42	Manifestations	manifestation	NNS
cord-332109-ont0tqpn	443	43	of	of	IN
cord-332109-ont0tqpn	443	44	Hospitalized	Hospitalized	NNP
cord-332109-ont0tqpn	443	45	Patients	Patients	NNP
cord-332109-ont0tqpn	443	46	with	with	IN
cord-332109-ont0tqpn	443	47	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	443	48	Disease	Disease	NNP
cord-332109-ont0tqpn	443	49	SARS	SARS	NNP
cord-332109-ont0tqpn	443	50	-	-	HYPH
cord-332109-ont0tqpn	443	51	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	443	52	and	and	CC
cord-332109-ont0tqpn	443	53	viral	viral	JJ
cord-332109-ont0tqpn	443	54	sepsis	sepsis	NN
cord-332109-ont0tqpn	443	55	:	:	:
cord-332109-ont0tqpn	444	1	Observations	observation	NNS
cord-332109-ont0tqpn	444	2	and	and	CC
cord-332109-ont0tqpn	444	3	hypotheses	hypothesis	NNS
cord-332109-ont0tqpn	445	1	The	the	DT
cord-332109-ont0tqpn	445	2	cytokine	cytokine	NN
cord-332109-ont0tqpn	445	3	storm	storm	NN
cord-332109-ont0tqpn	445	4	in	in	IN
cord-332109-ont0tqpn	445	5	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	445	6	:	:	:
cord-332109-ont0tqpn	445	7	An	an	DT
cord-332109-ont0tqpn	445	8	overview	overview	NN
cord-332109-ont0tqpn	445	9	of	of	IN
cord-332109-ont0tqpn	445	10	the	the	DT
cord-332109-ont0tqpn	445	11	involvement	involvement	NN
cord-332109-ont0tqpn	445	12	of	of	IN
cord-332109-ont0tqpn	445	13	the	the	DT
cord-332109-ont0tqpn	445	14	chemokine	chemokine	NN
cord-332109-ont0tqpn	445	15	/	/	SYM
cord-332109-ont0tqpn	445	16	chemokine	chemokine	NN
cord-332109-ont0tqpn	445	17	-	-	HYPH
cord-332109-ont0tqpn	445	18	receptor	receptor	NN
cord-332109-ont0tqpn	445	19	system	system	NN
cord-332109-ont0tqpn	446	1	The	the	DT
cord-332109-ont0tqpn	446	2	Global	Global	NNP
cord-332109-ont0tqpn	446	3	Phosphorylation	Phosphorylation	NNP
cord-332109-ont0tqpn	446	4	Landscape	Landscape	NNP
cord-332109-ont0tqpn	446	5	of	of	IN
cord-332109-ont0tqpn	446	6	SARS	SARS	NNP
cord-332109-ont0tqpn	446	7	-	-	HYPH
cord-332109-ont0tqpn	446	8	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	446	9	Infection	Infection	NNP
cord-332109-ont0tqpn	446	10	Clinical	clinical	JJ
cord-332109-ont0tqpn	446	11	features	feature	NNS
cord-332109-ont0tqpn	446	12	of	of	IN
cord-332109-ont0tqpn	446	13	patients	patient	NNS
cord-332109-ont0tqpn	446	14	infected	infect	VBN
cord-332109-ont0tqpn	446	15	with	with	IN
cord-332109-ont0tqpn	446	16	2019	2019	CD
cord-332109-ont0tqpn	446	17	novel	novel	JJ
cord-332109-ont0tqpn	446	18	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	446	19	in	in	IN
cord-332109-ont0tqpn	446	20	Longitudinal	longitudinal	JJ
cord-332109-ont0tqpn	446	21	characteristics	characteristic	NNS
cord-332109-ont0tqpn	446	22	of	of	IN
cord-332109-ont0tqpn	446	23	lymphocyte	lymphocyte	NN
cord-332109-ont0tqpn	446	24	responses	response	NNS
cord-332109-ont0tqpn	446	25	and	and	CC
cord-332109-ont0tqpn	446	26	cytokine	cytokine	NN
cord-332109-ont0tqpn	446	27	profiles	profile	NNS
cord-332109-ont0tqpn	446	28	in	in	IN
cord-332109-ont0tqpn	446	29	the	the	DT
cord-332109-ont0tqpn	446	30	peripheral	peripheral	JJ
cord-332109-ont0tqpn	446	31	blood	blood	NN
cord-332109-ont0tqpn	446	32	of	of	IN
cord-332109-ont0tqpn	446	33	SARS	SARS	NNP
cord-332109-ont0tqpn	446	34	-	-	HYPH
cord-332109-ont0tqpn	446	35	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	446	36	Correlation	Correlation	NNP
cord-332109-ont0tqpn	446	37	Analysis	Analysis	NNP
cord-332109-ont0tqpn	446	38	Between	between	IN
cord-332109-ont0tqpn	446	39	Disease	Disease	NNP
cord-332109-ont0tqpn	446	40	Severity	Severity	NNP
cord-332109-ont0tqpn	446	41	and	and	CC
cord-332109-ont0tqpn	446	42	Inflammation	inflammation	NN
cord-332109-ont0tqpn	446	43	-	-	HYPH
cord-332109-ont0tqpn	446	44	related	relate	VBN
cord-332109-ont0tqpn	446	45	Parameters	parameter	NNS
cord-332109-ont0tqpn	446	46	in	in	IN
cord-332109-ont0tqpn	446	47	Patients	patient	NNS
cord-332109-ont0tqpn	446	48	with	with	IN
cord-332109-ont0tqpn	446	49	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	446	50	Pneumonia	Pneumonia	NNP
cord-332109-ont0tqpn	446	51	Innate	Innate	NNP
cord-332109-ont0tqpn	446	52	immunity	immunity	NN
cord-332109-ont0tqpn	446	53	to	to	IN
cord-332109-ont0tqpn	446	54	influenza	influenza	NN
cord-332109-ont0tqpn	446	55	virus	virus	NN
cord-332109-ont0tqpn	446	56	infection	infection	NN
cord-332109-ont0tqpn	447	1	The	the	DT
cord-332109-ont0tqpn	447	2	potential	potential	JJ
cord-332109-ont0tqpn	447	3	role	role	NN
cord-332109-ont0tqpn	447	4	of	of	IN
cord-332109-ont0tqpn	447	5	IL-6	IL-6	NNP
cord-332109-ont0tqpn	447	6	in	in	IN
cord-332109-ont0tqpn	447	7	monitoring	monitor	VBG
cord-332109-ont0tqpn	447	8	severe	severe	JJ
cord-332109-ont0tqpn	447	9	case	case	NN
cord-332109-ont0tqpn	447	10	of	of	IN
cord-332109-ont0tqpn	447	11	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	447	12	disease	disease	NN
cord-332109-ont0tqpn	447	13	2019	2019	CD
cord-332109-ont0tqpn	447	14	Type	Type	NNP
cord-332109-ont0tqpn	447	15	III	III	NNP
cord-332109-ont0tqpn	447	16	interferons	interferon	NNS
cord-332109-ont0tqpn	447	17	disrupt	disrupt	VBP
cord-332109-ont0tqpn	447	18	the	the	DT
cord-332109-ont0tqpn	447	19	lung	lung	NN
cord-332109-ont0tqpn	447	20	epithelial	epithelial	JJ
cord-332109-ont0tqpn	447	21	barrier	barrier	NN
cord-332109-ont0tqpn	447	22	upon	upon	IN
cord-332109-ont0tqpn	447	23	viral	viral	JJ
cord-332109-ont0tqpn	447	24	recognition	recognition	NN
cord-332109-ont0tqpn	447	25	Up	up	IN
cord-332109-ont0tqpn	447	26	-	-	HYPH
cord-332109-ont0tqpn	447	27	regulation	regulation	NN
cord-332109-ont0tqpn	447	28	of	of	IN
cord-332109-ont0tqpn	447	29	IL-6	IL-6	NNP
cord-332109-ont0tqpn	447	30	and	and	CC
cord-332109-ont0tqpn	447	31	TNF	TNF	NNP
cord-332109-ont0tqpn	447	32	-	-	HYPH
cord-332109-ont0tqpn	447	33	alpha	alpha	NN
cord-332109-ont0tqpn	447	34	induced	induce	VBN
cord-332109-ont0tqpn	447	35	by	by	IN
cord-332109-ont0tqpn	447	36	SARS	SARS	NNP
cord-332109-ont0tqpn	447	37	-	-	HYPH
cord-332109-ont0tqpn	447	38	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	447	39	spike	spike	NN
cord-332109-ont0tqpn	447	40	protein	protein	NN
cord-332109-ont0tqpn	447	41	in	in	IN
cord-332109-ont0tqpn	447	42	murine	murine	JJ
cord-332109-ont0tqpn	447	43	macrophages	macrophage	NNS
cord-332109-ont0tqpn	447	44	via	via	IN
cord-332109-ont0tqpn	447	45	NF	NF	NNP
cord-332109-ont0tqpn	447	46	-	-	HYPH
cord-332109-ont0tqpn	447	47	kappaB	kappaB	NNP
cord-332109-ont0tqpn	447	48	pathway	pathway	NN
cord-332109-ont0tqpn	448	1	The	the	DT
cord-332109-ont0tqpn	448	2	cytokine	cytokine	NN
cord-332109-ont0tqpn	448	3	storm	storm	NN
cord-332109-ont0tqpn	448	4	of	of	IN
cord-332109-ont0tqpn	448	5	severe	severe	JJ
cord-332109-ont0tqpn	448	6	influenza	influenza	NN
cord-332109-ont0tqpn	448	7	and	and	CC
cord-332109-ont0tqpn	448	8	development	development	NN
cord-332109-ont0tqpn	448	9	of	of	IN
cord-332109-ont0tqpn	448	10	immunomodulatory	immunomodulatory	JJ
cord-332109-ont0tqpn	448	11	therapy	therapy	NN
cord-332109-ont0tqpn	448	12	Neuro	Neuro	NNP
cord-332109-ont0tqpn	448	13	-	-	HYPH
cord-332109-ont0tqpn	448	14	immune	immune	JJ
cord-332109-ont0tqpn	448	15	-	-	HYPH
cord-332109-ont0tqpn	448	16	endocrine	endocrine	JJ
cord-332109-ont0tqpn	448	17	functional	functional	JJ
cord-332109-ont0tqpn	448	18	system	system	NN
cord-332109-ont0tqpn	448	19	and	and	CC
cord-332109-ont0tqpn	448	20	vascular	vascular	JJ
cord-332109-ont0tqpn	448	21	pathology	pathology	NN
cord-332109-ont0tqpn	448	22	Effect	effect	NN
cord-332109-ont0tqpn	448	23	of	of	IN
cord-332109-ont0tqpn	448	24	growth	growth	NN
cord-332109-ont0tqpn	448	25	hormone	hormone	NN
cord-332109-ont0tqpn	448	26	(	(	-LRB-
cord-332109-ont0tqpn	448	27	GH	GH	NNP
cord-332109-ont0tqpn	448	28	)	)	-RRB-
cord-332109-ont0tqpn	448	29	on	on	IN
cord-332109-ont0tqpn	448	30	the	the	DT
cord-332109-ont0tqpn	448	31	immune	immune	JJ
cord-332109-ont0tqpn	448	32	system	system	NN
cord-332109-ont0tqpn	448	33	Functional	functional	JJ
cord-332109-ont0tqpn	448	34	role	role	NN
cord-332109-ont0tqpn	448	35	of	of	IN
cord-332109-ont0tqpn	448	36	acetylcholine	acetylcholine	NN
cord-332109-ont0tqpn	448	37	in	in	IN
cord-332109-ont0tqpn	448	38	the	the	DT
cord-332109-ont0tqpn	448	39	immune	immune	JJ
cord-332109-ont0tqpn	448	40	system	system	NN
cord-332109-ont0tqpn	448	41	Activation	Activation	NNP
cord-332109-ont0tqpn	448	42	of	of	IN
cord-332109-ont0tqpn	448	43	the	the	DT
cord-332109-ont0tqpn	448	44	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	448	45	transcription	transcription	NN
cord-332109-ont0tqpn	448	46	factor	factor	NN
cord-332109-ont0tqpn	448	47	nuclear	nuclear	JJ
cord-332109-ont0tqpn	448	48	factor	factor	NN
cord-332109-ont0tqpn	448	49	interleukin-6	interleukin-6	RB
cord-332109-ont0tqpn	448	50	during	during	IN
cord-332109-ont0tqpn	448	51	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	448	52	and	and	CC
cord-332109-ont0tqpn	448	53	psychological	psychological	JJ
cord-332109-ont0tqpn	448	54	stress	stress	NN
cord-332109-ont0tqpn	448	55	in	in	IN
cord-332109-ont0tqpn	448	56	the	the	DT
cord-332109-ont0tqpn	448	57	brain	brain	NN
cord-332109-ont0tqpn	448	58	Microglia	Microglia	NNP
cord-332109-ont0tqpn	448	59	in	in	IN
cord-332109-ont0tqpn	448	60	normal	normal	JJ
cord-332109-ont0tqpn	448	61	condition	condition	NN
cord-332109-ont0tqpn	448	62	and	and	CC
cord-332109-ont0tqpn	448	63	pathology	pathology	NN
cord-332109-ont0tqpn	448	64	Neural	neural	JJ
cord-332109-ont0tqpn	448	65	regulation	regulation	NN
cord-332109-ont0tqpn	448	66	of	of	IN
cord-332109-ont0tqpn	448	67	innate	innate	JJ
cord-332109-ont0tqpn	448	68	immunity	immunity	NN
cord-332109-ont0tqpn	448	69	:	:	:
cord-332109-ont0tqpn	448	70	A	a	DT
cord-332109-ont0tqpn	448	71	coordinated	coordinated	JJ
cord-332109-ont0tqpn	448	72	nonspecific	nonspecific	JJ
cord-332109-ont0tqpn	448	73	host	host	NN
cord-332109-ont0tqpn	448	74	response	response	NN
cord-332109-ont0tqpn	448	75	to	to	IN
cord-332109-ont0tqpn	448	76	pathogens	pathogen	NNS
cord-332109-ont0tqpn	448	77	Activation	Activation	NNP
cord-332109-ont0tqpn	448	78	of	of	IN
cord-332109-ont0tqpn	448	79	the	the	DT
cord-332109-ont0tqpn	448	80	hypothalamic	hypothalamic	JJ
cord-332109-ont0tqpn	448	81	-	-	HYPH
cord-332109-ont0tqpn	448	82	pituitary	pituitary	NN
cord-332109-ont0tqpn	448	83	-	-	HYPH
cord-332109-ont0tqpn	448	84	adrenal	adrenal	NN
cord-332109-ont0tqpn	448	85	axis	axis	NN
cord-332109-ont0tqpn	448	86	by	by	IN
cord-332109-ont0tqpn	448	87	addictive	addictive	JJ
cord-332109-ont0tqpn	448	88	drugs	drug	NNS
cord-332109-ont0tqpn	448	89	:	:	:
cord-332109-ont0tqpn	448	90	Different	different	JJ
cord-332109-ont0tqpn	448	91	pathways	pathway	NNS
cord-332109-ont0tqpn	448	92	,	,	,
cord-332109-ont0tqpn	448	93	common	common	JJ
cord-332109-ont0tqpn	448	94	outcome	outcome	NN
cord-332109-ont0tqpn	448	95	Into	into	IN
cord-332109-ont0tqpn	448	96	the	the	DT
cord-332109-ont0tqpn	448	97	eye	eye	NN
cord-332109-ont0tqpn	448	98	of	of	IN
cord-332109-ont0tqpn	448	99	the	the	DT
cord-332109-ont0tqpn	448	100	cytokine	cytokine	NN
cord-332109-ont0tqpn	448	101	storm	storm	NN
cord-332109-ont0tqpn	448	102	.	.	.
cord-332109-ont0tqpn	449	1	Microbiol	Microbiol	NNP
cord-332109-ont0tqpn	450	1	An	an	DT
cord-332109-ont0tqpn	450	2	interferon	interferon	NN
cord-332109-ont0tqpn	450	3	-	-	HYPH
cord-332109-ont0tqpn	450	4	gamma	gamma	NN
cord-332109-ont0tqpn	450	5	-	-	HYPH
cord-332109-ont0tqpn	450	6	related	relate	VBN
cord-332109-ont0tqpn	450	7	cytokine	cytokine	NN
cord-332109-ont0tqpn	450	8	storm	storm	NN
cord-332109-ont0tqpn	450	9	in	in	IN
cord-332109-ont0tqpn	450	10	SARS	SARS	NNP
cord-332109-ont0tqpn	450	11	patients	patient	NNS
cord-332109-ont0tqpn	450	12	Drugs	drug	NNS
cord-332109-ont0tqpn	450	13	of	of	IN
cord-332109-ont0tqpn	450	14	abuse	abuse	NN
cord-332109-ont0tqpn	450	15	and	and	CC
cord-332109-ont0tqpn	450	16	blood	blood	NN
cord-332109-ont0tqpn	450	17	-	-	HYPH
cord-332109-ont0tqpn	450	18	brain	brain	NN
cord-332109-ont0tqpn	450	19	barrier	barrier	NN
cord-332109-ont0tqpn	450	20	endothelial	endothelial	JJ
cord-332109-ont0tqpn	450	21	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	450	22	:	:	:
cord-332109-ont0tqpn	451	1	A	a	DT
cord-332109-ont0tqpn	451	2	focus	focus	NN
cord-332109-ont0tqpn	451	3	on	on	IN
cord-332109-ont0tqpn	451	4	the	the	DT
cord-332109-ont0tqpn	451	5	role	role	NN
cord-332109-ont0tqpn	451	6	of	of	IN
cord-332109-ont0tqpn	451	7	oxidative	oxidative	JJ
cord-332109-ont0tqpn	451	8	stress	stress	NN
cord-332109-ont0tqpn	451	9	Cigarette	cigarette	NN
cord-332109-ont0tqpn	451	10	smoking	smoking	NN
cord-332109-ont0tqpn	451	11	and	and	CC
cord-332109-ont0tqpn	451	12	progression	progression	NN
cord-332109-ont0tqpn	451	13	of	of	IN
cord-332109-ont0tqpn	451	14	atherosclerosis	atherosclerosis	NN
cord-332109-ont0tqpn	451	15	:	:	:
cord-332109-ont0tqpn	452	1	The	the	DT
cord-332109-ont0tqpn	452	2	Atherosclerosis	atherosclerosis	NN
cord-332109-ont0tqpn	452	3	Risk	risk	NN
cord-332109-ont0tqpn	452	4	in	in	IN
cord-332109-ont0tqpn	452	5	Communities	Communities	NNP
cord-332109-ont0tqpn	452	6	(	(	-LRB-
cord-332109-ont0tqpn	452	7	ARIC	ARIC	NNP
cord-332109-ont0tqpn	452	8	)	)	-RRB-
cord-332109-ont0tqpn	452	9	Study	Study	NNP
cord-332109-ont0tqpn	452	10	Dose	Dose	NNP
cord-332109-ont0tqpn	452	11	-	-	HYPH
cord-332109-ont0tqpn	452	12	Response	response	NN
cord-332109-ont0tqpn	452	13	Relationship	relationship	NN
cord-332109-ont0tqpn	452	14	Between	between	IN
cord-332109-ont0tqpn	452	15	Cigarette	cigarette	NN
cord-332109-ont0tqpn	452	16	Smoking	smoking	NN
cord-332109-ont0tqpn	452	17	and	and	CC
cord-332109-ont0tqpn	452	18	Risk	risk	NN
cord-332109-ont0tqpn	452	19	of	of	IN
cord-332109-ont0tqpn	452	20	Ischemic	Ischemic	NNP
cord-332109-ont0tqpn	452	21	Stroke	Stroke	NNP
cord-332109-ont0tqpn	452	22	in	in	IN
cord-332109-ont0tqpn	452	23	Young	Young	NNP
cord-332109-ont0tqpn	452	24	Women	woman	NNS
cord-332109-ont0tqpn	452	25	Smoking	smoke	VBG
cord-332109-ont0tqpn	453	1	Is	be	VBZ
cord-332109-ont0tqpn	453	2	Associated	associate	VBN
cord-332109-ont0tqpn	453	3	with	with	IN
cord-332109-ont0tqpn	453	4	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	453	5	Progression	Progression	NNP
cord-332109-ont0tqpn	453	6	:	:	:
cord-332109-ont0tqpn	453	7	A	a	DT
cord-332109-ont0tqpn	453	8	Meta	Meta	NNP
cord-332109-ont0tqpn	453	9	-	-	HYPH
cord-332109-ont0tqpn	453	10	analysis	analysis	NN
cord-332109-ont0tqpn	453	11	Effects	effect	NNS
cord-332109-ont0tqpn	453	12	of	of	IN
cord-332109-ont0tqpn	453	13	cigarette	cigarette	NN
cord-332109-ont0tqpn	453	14	smoke	smoke	NN
cord-332109-ont0tqpn	453	15	on	on	IN
cord-332109-ont0tqpn	453	16	the	the	DT
cord-332109-ont0tqpn	453	17	immune	immune	JJ
cord-332109-ont0tqpn	453	18	system	system	NN
cord-332109-ont0tqpn	453	19	Effects	effect	NNS
cord-332109-ont0tqpn	453	20	of	of	IN
cord-332109-ont0tqpn	453	21	nicotine	nicotine	NN
cord-332109-ont0tqpn	453	22	on	on	IN
cord-332109-ont0tqpn	453	23	the	the	DT
cord-332109-ont0tqpn	453	24	immune	immune	JJ
cord-332109-ont0tqpn	453	25	response	response	NN
cord-332109-ont0tqpn	453	26	.	.	.
cord-332109-ont0tqpn	454	1	II	II	NNP
cord-332109-ont0tqpn	454	2	.	.	.
cord-332109-ont0tqpn	455	1	Chronic	chronic	JJ
cord-332109-ont0tqpn	455	2	nicotine	nicotine	NN
cord-332109-ont0tqpn	455	3	treatment	treatment	NN
cord-332109-ont0tqpn	455	4	induces	induce	VBZ
cord-332109-ont0tqpn	455	5	T	T	NNP
cord-332109-ont0tqpn	455	6	cell	cell	NN
cord-332109-ont0tqpn	455	7	anergy	anergy	NN
cord-332109-ont0tqpn	455	8	Are	be	VBP
cord-332109-ont0tqpn	455	9	healthy	healthy	JJ
cord-332109-ont0tqpn	455	10	smokers	smoker	NNS
cord-332109-ont0tqpn	455	11	really	really	RB
cord-332109-ont0tqpn	455	12	healthy	healthy	JJ
cord-332109-ont0tqpn	455	13	?	?	.
cord-332109-ont0tqpn	456	1	COVID-19	covid-19	VB
cord-332109-ont0tqpn	456	2	and	and	CC
cord-332109-ont0tqpn	456	3	smoking	smoking	NN
cord-332109-ont0tqpn	456	4	:	:	:
cord-332109-ont0tqpn	457	1	A	a	DT
cord-332109-ont0tqpn	457	2	systematic	systematic	JJ
cord-332109-ont0tqpn	457	3	review	review	NN
cord-332109-ont0tqpn	457	4	of	of	IN
cord-332109-ont0tqpn	457	5	the	the	DT
cord-332109-ont0tqpn	457	6	evidence	evidence	NN
cord-332109-ont0tqpn	457	7	Nicotine	Nicotine	NNP
cord-332109-ont0tqpn	457	8	and	and	CC
cord-332109-ont0tqpn	457	9	Cotinine	cotinine	NN
cord-332109-ont0tqpn	457	10	Modulate	modulate	VBP
cord-332109-ont0tqpn	457	11	Cerebral	Cerebral	NNP
cord-332109-ont0tqpn	457	12	Microvascular	Microvascular	NNP
cord-332109-ont0tqpn	457	13	Permeability	Permeability	NNP
cord-332109-ont0tqpn	457	14	and	and	CC
cord-332109-ont0tqpn	457	15	Protein	Protein	NNP
cord-332109-ont0tqpn	457	16	Expression	Expression	NNP
cord-332109-ont0tqpn	457	17	of	of	IN
cord-332109-ont0tqpn	457	18	ZO-1	ZO-1	NNP
cord-332109-ont0tqpn	457	19	through	through	IN
cord-332109-ont0tqpn	457	20	Nicotinic	Nicotinic	NNP
cord-332109-ont0tqpn	457	21	Acetylcholine	Acetylcholine	NNP
cord-332109-ont0tqpn	457	22	Receptors	receptor	NNS
cord-332109-ont0tqpn	457	23	Expressed	express	VBD
cord-332109-ont0tqpn	457	24	on	on	IN
cord-332109-ont0tqpn	457	25	Brain	Brain	NNP
cord-332109-ont0tqpn	457	26	Endothelial	Endothelial	NNP
cord-332109-ont0tqpn	457	27	Cells	Cells	NNP
cord-332109-ont0tqpn	457	28	Effect	effect	NN
cord-332109-ont0tqpn	457	29	of	of	IN
cord-332109-ont0tqpn	457	30	nicotine	nicotine	NN
cord-332109-ont0tqpn	457	31	and	and	CC
cord-332109-ont0tqpn	457	32	polyaromtic	polyaromtic	JJ
cord-332109-ont0tqpn	457	33	hydrocarbons	hydrocarbon	NNS
cord-332109-ont0tqpn	457	34	on	on	IN
cord-332109-ont0tqpn	457	35	cerebral	cerebral	JJ
cord-332109-ont0tqpn	457	36	endothelial	endothelial	JJ
cord-332109-ont0tqpn	457	37	cells	cell	NNS
cord-332109-ont0tqpn	457	38	Comparison	comparison	NN
cord-332109-ont0tqpn	457	39	of	of	IN
cord-332109-ont0tqpn	457	40	the	the	DT
cord-332109-ont0tqpn	457	41	effects	effect	NNS
cord-332109-ont0tqpn	457	42	of	of	IN
cord-332109-ont0tqpn	457	43	nicotine	nicotine	NN
cord-332109-ont0tqpn	457	44	upon	upon	IN
cord-332109-ont0tqpn	457	45	the	the	DT
cord-332109-ont0tqpn	457	46	transcellular	transcellular	JJ
cord-332109-ont0tqpn	457	47	electrical	electrical	JJ
cord-332109-ont0tqpn	457	48	resistance	resistance	NN
cord-332109-ont0tqpn	457	49	and	and	CC
cord-332109-ont0tqpn	457	50	sucrose	sucrose	NN
cord-332109-ont0tqpn	457	51	permeability	permeability	NN
cord-332109-ont0tqpn	457	52	of	of	IN
cord-332109-ont0tqpn	457	53	human	human	JJ
cord-332109-ont0tqpn	457	54	ECV304	ECV304	NNP
cord-332109-ont0tqpn	457	55	/	/	SYM
cord-332109-ont0tqpn	457	56	rat	rat	NN
cord-332109-ont0tqpn	457	57	C6	c6	NN
cord-332109-ont0tqpn	457	58	co	co	NNS
cord-332109-ont0tqpn	457	59	-	-	NNS
cord-332109-ont0tqpn	457	60	cultures	culture	NNS
cord-332109-ont0tqpn	457	61	and	and	CC
cord-332109-ont0tqpn	457	62	human	human	JJ
cord-332109-ont0tqpn	457	63	CaCo(2	CaCo(2	NNP
cord-332109-ont0tqpn	457	64	)	)	-RRB-
cord-332109-ont0tqpn	457	65	cells	cell	VBZ
cord-332109-ont0tqpn	457	66	Nicotine	nicotine	NN
cord-332109-ont0tqpn	457	67	increases	increase	NNS
cord-332109-ont0tqpn	457	68	in	in	IN
cord-332109-ont0tqpn	457	69	vivo	vivo	NN
cord-332109-ont0tqpn	457	70	blood	blood	NN
cord-332109-ont0tqpn	457	71	-	-	HYPH
cord-332109-ont0tqpn	457	72	brain	brain	NN
cord-332109-ont0tqpn	457	73	barrier	barrier	NN
cord-332109-ont0tqpn	457	74	permeability	permeability	NN
cord-332109-ont0tqpn	457	75	and	and	CC
cord-332109-ont0tqpn	457	76	alters	alter	VBZ
cord-332109-ont0tqpn	457	77	cerebral	cerebral	JJ
cord-332109-ont0tqpn	457	78	microvascular	microvascular	JJ
cord-332109-ont0tqpn	457	79	tight	tight	JJ
cord-332109-ont0tqpn	457	80	junction	junction	NN
cord-332109-ont0tqpn	457	81	protein	protein	NN
cord-332109-ont0tqpn	457	82	distribution	distribution	NN
cord-332109-ont0tqpn	457	83	Enhanced	Enhanced	NNP
cord-332109-ont0tqpn	457	84	Escherichia	Escherichia	NNP
cord-332109-ont0tqpn	457	85	coli	coli	VBZ
cord-332109-ont0tqpn	457	86	invasion	invasion	NN
cord-332109-ont0tqpn	457	87	of	of	IN
cord-332109-ont0tqpn	457	88	human	human	JJ
cord-332109-ont0tqpn	457	89	brain	brain	NN
cord-332109-ont0tqpn	457	90	microvascular	microvascular	JJ
cord-332109-ont0tqpn	457	91	endothelial	endothelial	JJ
cord-332109-ont0tqpn	457	92	cells	cell	NNS
cord-332109-ont0tqpn	457	93	is	be	VBZ
cord-332109-ont0tqpn	457	94	associated	associate	VBN
cord-332109-ont0tqpn	457	95	with	with	IN
cord-332109-ont0tqpn	457	96	alterations	alteration	NNS
cord-332109-ont0tqpn	457	97	in	in	IN
cord-332109-ont0tqpn	457	98	cytoskeleton	cytoskeleton	NN
cord-332109-ont0tqpn	457	99	induced	induce	VBN
cord-332109-ont0tqpn	457	100	by	by	IN
cord-332109-ont0tqpn	457	101	nicotine	nicotine	NN
cord-332109-ont0tqpn	457	102	Pathophysiological	Pathophysiological	NNP
cord-332109-ont0tqpn	457	103	impact	impact	NN
cord-332109-ont0tqpn	457	104	of	of	IN
cord-332109-ont0tqpn	457	105	cigarette	cigarette	NN
cord-332109-ont0tqpn	457	106	smoke	smoke	NN
cord-332109-ont0tqpn	457	107	exposure	exposure	NN
cord-332109-ont0tqpn	457	108	on	on	IN
cord-332109-ont0tqpn	457	109	the	the	DT
cord-332109-ont0tqpn	457	110	cerebrovascular	cerebrovascular	JJ
cord-332109-ont0tqpn	457	111	system	system	NN
cord-332109-ont0tqpn	457	112	with	with	IN
cord-332109-ont0tqpn	457	113	a	a	DT
cord-332109-ont0tqpn	457	114	focus	focus	NN
cord-332109-ont0tqpn	457	115	on	on	IN
cord-332109-ont0tqpn	457	116	the	the	DT
cord-332109-ont0tqpn	457	117	blood	blood	NN
cord-332109-ont0tqpn	457	118	-	-	HYPH
cord-332109-ont0tqpn	457	119	brain	brain	NN
cord-332109-ont0tqpn	457	120	barrier	barrier	NN
cord-332109-ont0tqpn	457	121	:	:	:
cord-332109-ont0tqpn	457	122	Expanding	expand	VBG
cord-332109-ont0tqpn	457	123	the	the	DT
cord-332109-ont0tqpn	457	124	awareness	awareness	NN
cord-332109-ont0tqpn	457	125	of	of	IN
cord-332109-ont0tqpn	457	126	smoking	smoke	VBG
cord-332109-ont0tqpn	457	127	toxicity	toxicity	NN
cord-332109-ont0tqpn	457	128	in	in	IN
cord-332109-ont0tqpn	457	129	an	an	DT
cord-332109-ont0tqpn	457	130	underappreciated	underappreciated	JJ
cord-332109-ont0tqpn	457	131	area	area	NN
cord-332109-ont0tqpn	457	132	Nicotine	nicotine	NN
cord-332109-ont0tqpn	457	133	aggravates	aggravate	VBZ
cord-332109-ont0tqpn	457	134	the	the	DT
cord-332109-ont0tqpn	457	135	brain	brain	NN
cord-332109-ont0tqpn	457	136	postischemic	postischemic	NNP
cord-332109-ont0tqpn	457	137	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	457	138	response	response	NN
cord-332109-ont0tqpn	458	1	The	the	DT
cord-332109-ont0tqpn	458	2	Relationship	relationship	NN
cord-332109-ont0tqpn	458	3	between	between	IN
cord-332109-ont0tqpn	458	4	Alcohol	Alcohol	NNP
cord-332109-ont0tqpn	458	5	Consumption	Consumption	NNP
cord-332109-ont0tqpn	458	6	and	and	CC
cord-332109-ont0tqpn	458	7	Vascular	Vascular	NNP
cord-332109-ont0tqpn	458	8	Complications	Complications	NNPS
cord-332109-ont0tqpn	458	9	and	and	CC
cord-332109-ont0tqpn	458	10	Mortality	mortality	NN
cord-332109-ont0tqpn	458	11	in	in	IN
cord-332109-ont0tqpn	458	12	Individuals	individual	NNS
cord-332109-ont0tqpn	458	13	With	with	IN
cord-332109-ont0tqpn	458	14	Type	type	NN
cord-332109-ont0tqpn	458	15	2	2	CD
cord-332109-ont0tqpn	458	16	Diabetes	diabetes	NN
cord-332109-ont0tqpn	458	17	Habitual	habitual	JJ
cord-332109-ont0tqpn	458	18	alcohol	alcohol	NN
cord-332109-ont0tqpn	458	19	consumption	consumption	NN
cord-332109-ont0tqpn	458	20	is	be	VBZ
cord-332109-ont0tqpn	458	21	associated	associate	VBN
cord-332109-ont0tqpn	458	22	with	with	IN
cord-332109-ont0tqpn	458	23	lower	low	JJR
cord-332109-ont0tqpn	458	24	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	458	25	stress	stress	NN
cord-332109-ont0tqpn	458	26	responses	response	NNS
cord-332109-ont0tqpn	458	27	-	-	:
cord-332109-ont0tqpn	458	28	A	a	DT
cord-332109-ont0tqpn	458	29	novel	novel	JJ
cord-332109-ont0tqpn	458	30	explanation	explanation	NN
cord-332109-ont0tqpn	458	31	for	for	IN
cord-332109-ont0tqpn	458	32	the	the	DT
cord-332109-ont0tqpn	458	33	known	know	VBN
cord-332109-ont0tqpn	458	34	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	458	35	benefits	benefit	NNS
cord-332109-ont0tqpn	458	36	of	of	IN
cord-332109-ont0tqpn	458	37	alcohol	alcohol	NN
cord-332109-ont0tqpn	458	38	?	?	.
cord-332109-ont0tqpn	459	1	Stress	stress	NN
cord-332109-ont0tqpn	460	1	The	the	DT
cord-332109-ont0tqpn	460	2	Association	Association	NNP
cord-332109-ont0tqpn	460	3	of	of	IN
cord-332109-ont0tqpn	460	4	Alcohol	Alcohol	NNP
cord-332109-ont0tqpn	460	5	-	-	HYPH
cord-332109-ont0tqpn	460	6	Induced	Induced	NNP
cord-332109-ont0tqpn	460	7	Blackouts	Blackouts	NNPS
cord-332109-ont0tqpn	460	8	and	and	CC
cord-332109-ont0tqpn	460	9	Grayouts	Grayouts	NNPS
cord-332109-ont0tqpn	460	10	to	to	IN
cord-332109-ont0tqpn	460	11	Blood	blood	NN
cord-332109-ont0tqpn	460	12	Alcohol	Alcohol	NNP
cord-332109-ont0tqpn	460	13	Concentrations	concentration	NNS
cord-332109-ont0tqpn	460	14	Patterns	pattern	NNS
cord-332109-ont0tqpn	460	15	of	of	IN
cord-332109-ont0tqpn	460	16	gene	gene	NN
cord-332109-ont0tqpn	460	17	expression	expression	NN
cord-332109-ont0tqpn	460	18	in	in	IN
cord-332109-ont0tqpn	460	19	the	the	DT
cord-332109-ont0tqpn	460	20	frontal	frontal	JJ
cord-332109-ont0tqpn	460	21	cortex	cortex	NNP
cord-332109-ont0tqpn	460	22	discriminate	discriminate	VBP
cord-332109-ont0tqpn	460	23	alcoholic	alcoholic	JJ
cord-332109-ont0tqpn	460	24	from	from	IN
cord-332109-ont0tqpn	460	25	nonalcoholic	nonalcoholic	JJ
cord-332109-ont0tqpn	460	26	individuals	individual	NNS
cord-332109-ont0tqpn	460	27	Activation	Activation	NNP
cord-332109-ont0tqpn	460	28	of	of	IN
cord-332109-ont0tqpn	460	29	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	460	30	signaling	signaling	NN
cord-332109-ont0tqpn	460	31	by	by	IN
cord-332109-ont0tqpn	460	32	lipopolysaccharide	lipopolysaccharide	NN
cord-332109-ont0tqpn	460	33	produces	produce	VBZ
cord-332109-ont0tqpn	460	34	a	a	DT
cord-332109-ont0tqpn	460	35	prolonged	prolonged	JJ
cord-332109-ont0tqpn	460	36	increase	increase	NN
cord-332109-ont0tqpn	460	37	of	of	IN
cord-332109-ont0tqpn	460	38	voluntary	voluntary	JJ
cord-332109-ont0tqpn	460	39	alcohol	alcohol	NN
cord-332109-ont0tqpn	460	40	intake	intake	NN
cord-332109-ont0tqpn	460	41	in	in	IN
cord-332109-ont0tqpn	460	42	mice	mouse	NNS
cord-332109-ont0tqpn	460	43	Altered	alter	VBN
cord-332109-ont0tqpn	460	44	gene	gene	NN
cord-332109-ont0tqpn	460	45	expression	expression	NN
cord-332109-ont0tqpn	460	46	in	in	IN
cord-332109-ont0tqpn	460	47	the	the	DT
cord-332109-ont0tqpn	460	48	spleen	spleen	NN
cord-332109-ont0tqpn	460	49	of	of	IN
cord-332109-ont0tqpn	460	50	adolescent	adolescent	JJ
cord-332109-ont0tqpn	460	51	rats	rat	NNS
cord-332109-ont0tqpn	460	52	following	follow	VBG
cord-332109-ont0tqpn	460	53	high	high	JJ
cord-332109-ont0tqpn	460	54	ethanol	ethanol	NN
cord-332109-ont0tqpn	460	55	concentration	concentration	NN
cord-332109-ont0tqpn	460	56	binge	binge	NN
cord-332109-ont0tqpn	460	57	drinking	drink	VBG
cord-332109-ont0tqpn	460	58	Alcohol	alcohol	NN
cord-332109-ont0tqpn	460	59	,	,	,
cord-332109-ont0tqpn	460	60	inflammation	inflammation	NN
cord-332109-ont0tqpn	460	61	,	,	,
cord-332109-ont0tqpn	460	62	and	and	CC
cord-332109-ont0tqpn	460	63	gut	gut	NN
cord-332109-ont0tqpn	460	64	-	-	HYPH
cord-332109-ont0tqpn	460	65	liver	liver	NN
cord-332109-ont0tqpn	460	66	-	-	HYPH
cord-332109-ont0tqpn	460	67	brain	brain	NN
cord-332109-ont0tqpn	460	68	interactions	interaction	NNS
cord-332109-ont0tqpn	460	69	in	in	IN
cord-332109-ont0tqpn	460	70	tissue	tissue	NN
cord-332109-ont0tqpn	460	71	damage	damage	NN
cord-332109-ont0tqpn	460	72	and	and	CC
cord-332109-ont0tqpn	460	73	disease	disease	NN
cord-332109-ont0tqpn	460	74	development	development	NN
cord-332109-ont0tqpn	460	75	Involvement	Involvement	NNP
cord-332109-ont0tqpn	460	76	of	of	IN
cord-332109-ont0tqpn	460	77	the	the	DT
cord-332109-ont0tqpn	460	78	Hippocampus	Hippocampus	NNP
cord-332109-ont0tqpn	460	79	in	in	IN
cord-332109-ont0tqpn	460	80	Binge	Binge	NNP
cord-332109-ont0tqpn	460	81	Ethanol	ethanol	NN
cord-332109-ont0tqpn	460	82	-	-	HYPH
cord-332109-ont0tqpn	460	83	Induced	induce	VBN
cord-332109-ont0tqpn	460	84	Spleen	spleen	NN
cord-332109-ont0tqpn	460	85	Atrophy	Atrophy	NNP
cord-332109-ont0tqpn	460	86	in	in	IN
cord-332109-ont0tqpn	460	87	Adolescent	Adolescent	NNP
cord-332109-ont0tqpn	460	88	Rats	Rats	NNP
cord-332109-ont0tqpn	460	89	Comparative	comparative	JJ
cord-332109-ont0tqpn	460	90	risk	risk	NN
cord-332109-ont0tqpn	460	91	assessment	assessment	NN
cord-332109-ont0tqpn	460	92	of	of	IN
cord-332109-ont0tqpn	460	93	alcohol	alcohol	NN
cord-332109-ont0tqpn	460	94	,	,	,
cord-332109-ont0tqpn	460	95	tobacco	tobacco	NN
cord-332109-ont0tqpn	460	96	,	,	,
cord-332109-ont0tqpn	460	97	cannabis	cannabis	NN
cord-332109-ont0tqpn	460	98	and	and	CC
cord-332109-ont0tqpn	460	99	other	other	JJ
cord-332109-ont0tqpn	460	100	illicit	illicit	JJ
cord-332109-ont0tqpn	460	101	drugs	drug	NNS
cord-332109-ont0tqpn	460	102	using	use	VBG
cord-332109-ont0tqpn	460	103	the	the	DT
cord-332109-ont0tqpn	460	104	margin	margin	NN
cord-332109-ont0tqpn	460	105	of	of	IN
cord-332109-ont0tqpn	460	106	exposure	exposure	NN
cord-332109-ont0tqpn	460	107	approach	approach	NN
cord-332109-ont0tqpn	460	108	Structure	structure	NN
cord-332109-ont0tqpn	460	109	and	and	CC
cord-332109-ont0tqpn	460	110	function	function	NN
cord-332109-ont0tqpn	460	111	of	of	IN
cord-332109-ont0tqpn	460	112	the	the	DT
cord-332109-ont0tqpn	460	113	immune	immune	JJ
cord-332109-ont0tqpn	460	114	system	system	NN
cord-332109-ont0tqpn	460	115	in	in	IN
cord-332109-ont0tqpn	460	116	the	the	DT
cord-332109-ont0tqpn	460	117	spleen	spleen	NN
cord-332109-ont0tqpn	460	118	Effects	effect	NNS
cord-332109-ont0tqpn	460	119	of	of	IN
cord-332109-ont0tqpn	460	120	chronic	chronic	JJ
cord-332109-ont0tqpn	460	121	ethanol	ethanol	NN
cord-332109-ont0tqpn	460	122	drinking	drinking	NN
cord-332109-ont0tqpn	460	123	on	on	IN
cord-332109-ont0tqpn	460	124	the	the	DT
cord-332109-ont0tqpn	460	125	blood	blood	NN
cord-332109-ont0tqpn	460	126	-	-	HYPH
cord-332109-ont0tqpn	460	127	brain	brain	NN
cord-332109-ont0tqpn	460	128	barrier	barrier	NN
cord-332109-ont0tqpn	460	129	and	and	CC
cord-332109-ont0tqpn	460	130	ensuing	ensue	VBG
cord-332109-ont0tqpn	460	131	neuronal	neuronal	JJ
cord-332109-ont0tqpn	460	132	toxicity	toxicity	NN
cord-332109-ont0tqpn	460	133	in	in	IN
cord-332109-ont0tqpn	460	134	alcohol	alcohol	NN
cord-332109-ont0tqpn	460	135	-	-	HYPH
cord-332109-ont0tqpn	460	136	preferring	prefer	VBG
cord-332109-ont0tqpn	460	137	rats	rat	NNS
cord-332109-ont0tqpn	460	138	subjected	subject	VBN
cord-332109-ont0tqpn	460	139	to	to	IN
cord-332109-ont0tqpn	460	140	intraperitoneal	intraperitoneal	JJ
cord-332109-ont0tqpn	460	141	LPS	LPS	NNP
cord-332109-ont0tqpn	460	142	injection	injection	NN
cord-332109-ont0tqpn	460	143	Alcohol	alcohol	NN
cord-332109-ont0tqpn	460	144	-	-	HYPH
cord-332109-ont0tqpn	460	145	induced	induce	VBN
cord-332109-ont0tqpn	460	146	blood	blood	NN
cord-332109-ont0tqpn	460	147	-	-	HYPH
cord-332109-ont0tqpn	460	148	brain	brain	NN
cord-332109-ont0tqpn	460	149	barrier	barrier	NN
cord-332109-ont0tqpn	460	150	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	460	151	is	be	VBZ
cord-332109-ont0tqpn	460	152	mediated	mediate	VBN
cord-332109-ont0tqpn	460	153	via	via	IN
cord-332109-ont0tqpn	460	154	inositol	inositol	NN
cord-332109-ont0tqpn	460	155	1,4,5-triphosphate	1,4,5-triphosphate	CD
cord-332109-ont0tqpn	460	156	receptor	receptor	NN
cord-332109-ont0tqpn	460	157	(	(	-LRB-
cord-332109-ont0tqpn	460	158	IP3R)-gated	ip3r)-gate	VBN
cord-332109-ont0tqpn	460	159	intracellular	intracellular	JJ
cord-332109-ont0tqpn	460	160	calcium	calcium	NN
cord-332109-ont0tqpn	460	161	release	release	NN
cord-332109-ont0tqpn	460	162	Alcohol	alcohol	NN
cord-332109-ont0tqpn	460	163	-	-	HYPH
cord-332109-ont0tqpn	460	164	induced	induce	VBN
cord-332109-ont0tqpn	460	165	oxidative	oxidative	JJ
cord-332109-ont0tqpn	460	166	stress	stress	NN
cord-332109-ont0tqpn	460	167	in	in	IN
cord-332109-ont0tqpn	460	168	brain	brain	NN
cord-332109-ont0tqpn	460	169	endothelial	endothelial	NN
cord-332109-ont0tqpn	460	170	cells	cell	NNS
cord-332109-ont0tqpn	460	171	causes	cause	VBZ
cord-332109-ont0tqpn	460	172	blood	blood	NN
cord-332109-ont0tqpn	460	173	-	-	HYPH
cord-332109-ont0tqpn	460	174	brain	brain	NN
cord-332109-ont0tqpn	460	175	barrier	barrier	NN
cord-332109-ont0tqpn	460	176	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	460	177	Medicinal	medicinal	JJ
cord-332109-ont0tqpn	460	178	use	use	NN
cord-332109-ont0tqpn	460	179	of	of	IN
cord-332109-ont0tqpn	460	180	cannabis	cannabis	NN
cord-332109-ont0tqpn	460	181	in	in	IN
cord-332109-ont0tqpn	460	182	the	the	DT
cord-332109-ont0tqpn	460	183	United	United	NNP
cord-332109-ont0tqpn	460	184	States	States	NNP
cord-332109-ont0tqpn	460	185	:	:	:
cord-332109-ont0tqpn	460	186	Historical	historical	JJ
cord-332109-ont0tqpn	460	187	perspectives	perspective	NNS
cord-332109-ont0tqpn	460	188	,	,	,
cord-332109-ont0tqpn	460	189	current	current	JJ
cord-332109-ont0tqpn	460	190	trends	trend	NNS
cord-332109-ont0tqpn	460	191	,	,	,
cord-332109-ont0tqpn	460	192	and	and	CC
cord-332109-ont0tqpn	460	193	future	future	JJ
cord-332109-ont0tqpn	460	194	directions	direction	NNS
cord-332109-ont0tqpn	460	195	Therapeutic	therapeutic	JJ
cord-332109-ont0tqpn	460	196	potential	potential	NN
cord-332109-ont0tqpn	460	197	of	of	IN
cord-332109-ont0tqpn	460	198	cannabinoid	cannabinoid	NN
cord-332109-ont0tqpn	460	199	medicines	medicine	NNS
cord-332109-ont0tqpn	460	200	Pharmacological	pharmacological	JJ
cord-332109-ont0tqpn	460	201	actions	action	NNS
cord-332109-ont0tqpn	460	202	of	of	IN
cord-332109-ont0tqpn	460	203	cannabinoids	cannabinoid	NNS
cord-332109-ont0tqpn	460	204	CB2	CB2	NNP
cord-332109-ont0tqpn	460	205	receptor	receptor	NN
cord-332109-ont0tqpn	460	206	-	-	HYPH
cord-332109-ont0tqpn	460	207	mediated	mediate	VBN
cord-332109-ont0tqpn	460	208	migration	migration	NN
cord-332109-ont0tqpn	460	209	of	of	IN
cord-332109-ont0tqpn	460	210	immune	immune	JJ
cord-332109-ont0tqpn	460	211	cells	cell	NNS
cord-332109-ont0tqpn	461	1	:	:	:
cord-332109-ont0tqpn	461	2	It	-PRON-	PRP
cord-332109-ont0tqpn	461	3	can	can	MD
cord-332109-ont0tqpn	461	4	go	go	VB
cord-332109-ont0tqpn	461	5	either	either	DT
cord-332109-ont0tqpn	461	6	way	way	NN
cord-332109-ont0tqpn	462	1	Cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	462	2	effects	effect	NNS
cord-332109-ont0tqpn	462	3	of	of	IN
cord-332109-ont0tqpn	462	4	marijuana	marijuana	NN
cord-332109-ont0tqpn	462	5	and	and	CC
cord-332109-ont0tqpn	462	6	synthetic	synthetic	JJ
cord-332109-ont0tqpn	462	7	cannabinoids	cannabinoid	NNS
cord-332109-ont0tqpn	462	8	:	:	:
cord-332109-ont0tqpn	462	9	The	the	DT
cord-332109-ont0tqpn	462	10	good	good	NN
cord-332109-ont0tqpn	462	11	,	,	,
cord-332109-ont0tqpn	462	12	the	the	DT
cord-332109-ont0tqpn	462	13	bad	bad	JJ
cord-332109-ont0tqpn	462	14	,	,	,
cord-332109-ont0tqpn	462	15	and	and	CC
cord-332109-ont0tqpn	462	16	the	the	DT
cord-332109-ont0tqpn	462	17	ugly	ugly	JJ
cord-332109-ont0tqpn	462	18	Marijuana	Marijuana	NNP
cord-332109-ont0tqpn	462	19	use	use	NN
cord-332109-ont0tqpn	462	20	and	and	CC
cord-332109-ont0tqpn	462	21	brain	brain	NN
cord-332109-ont0tqpn	462	22	immune	immune	NN
cord-332109-ont0tqpn	462	23	mechanisms	mechanism	NNS
cord-332109-ont0tqpn	462	24	Harmful	harmful	JJ
cord-332109-ont0tqpn	462	25	Effects	effect	NNS
cord-332109-ont0tqpn	462	26	of	of	IN
cord-332109-ont0tqpn	462	27	Smoking	Smoking	NNP
cord-332109-ont0tqpn	462	28	Cannabis	Cannabis	NNP
cord-332109-ont0tqpn	462	29	:	:	:
cord-332109-ont0tqpn	462	30	A	a	DT
cord-332109-ont0tqpn	462	31	Cerebrovascular	Cerebrovascular	NNP
cord-332109-ont0tqpn	462	32	and	and	CC
cord-332109-ont0tqpn	462	33	Neurological	Neurological	NNP
cord-332109-ont0tqpn	462	34	Perspective	Perspective	NNP
cord-332109-ont0tqpn	462	35	Marijuana	Marijuana	NNP
cord-332109-ont0tqpn	462	36	and	and	CC
cord-332109-ont0tqpn	462	37	chronic	chronic	JJ
cord-332109-ont0tqpn	462	38	obstructive	obstructive	JJ
cord-332109-ont0tqpn	462	39	lung	lung	NN
cord-332109-ont0tqpn	462	40	disease	disease	NN
cord-332109-ont0tqpn	462	41	:	:	:
cord-332109-ont0tqpn	462	42	A	a	DT
cord-332109-ont0tqpn	462	43	population	population	NN
cord-332109-ont0tqpn	462	44	-	-	HYPH
cord-332109-ont0tqpn	462	45	based	base	VBN
cord-332109-ont0tqpn	462	46	study	study	NN
cord-332109-ont0tqpn	462	47	Does	do	VBZ
cord-332109-ont0tqpn	462	48	smoking	smoking	NN
cord-332109-ont0tqpn	462	49	marijuana	marijuana	NN
cord-332109-ont0tqpn	462	50	increase	increase	VB
cord-332109-ont0tqpn	462	51	the	the	DT
cord-332109-ont0tqpn	462	52	risk	risk	NN
cord-332109-ont0tqpn	462	53	of	of	IN
cord-332109-ont0tqpn	462	54	chronic	chronic	JJ
cord-332109-ont0tqpn	462	55	obstructive	obstructive	JJ
cord-332109-ont0tqpn	462	56	pulmonary	pulmonary	JJ
cord-332109-ont0tqpn	462	57	disease	disease	NN
cord-332109-ont0tqpn	462	58	?	?	.
cord-332109-ont0tqpn	463	1	Search	Search	NNP
cord-332109-ont0tqpn	463	2	of	of	IN
cord-332109-ont0tqpn	463	3	Preventative	Preventative	NNP
cord-332109-ont0tqpn	463	4	Strategies	strategy	NNS
cord-332109-ont0tqpn	463	5	:	:	:
cord-332109-ont0tqpn	464	1	Novel	Novel	NNP
cord-332109-ont0tqpn	464	2	Anti	Anti	NNP
cord-332109-ont0tqpn	464	3	-	-	JJ
cord-332109-ont0tqpn	464	4	Inflammatory	Inflammatory	NNP
cord-332109-ont0tqpn	464	5	High	High	NNP
cord-332109-ont0tqpn	464	6	-	-	HYPH
cord-332109-ont0tqpn	464	7	CBD	CBD	NNP
cord-332109-ont0tqpn	464	8	Cannabis	Cannabis	NNP
cord-332109-ont0tqpn	464	9	Sativa	sativa	NN
cord-332109-ont0tqpn	464	10	Extracts	extract	NNS
cord-332109-ont0tqpn	464	11	Modulate	modulate	VBP
cord-332109-ont0tqpn	464	12	ACE2	ACE2	NNP
cord-332109-ont0tqpn	464	13	Expression	expression	NN
cord-332109-ont0tqpn	464	14	in	in	IN
cord-332109-ont0tqpn	464	15	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	464	16	Gateway	Gateway	NNP
cord-332109-ont0tqpn	464	17	Tissues	Tissues	NNPS
cord-332109-ont0tqpn	464	18	.	.	.
cord-332109-ont0tqpn	465	1	Preprints	preprint	NNS
cord-332109-ont0tqpn	465	2	2020	2020	CD
cord-332109-ont0tqpn	466	1	The	the	DT
cord-332109-ont0tqpn	466	2	impact	impact	NN
cord-332109-ont0tqpn	466	3	of	of	IN
cord-332109-ont0tqpn	466	4	opioids	opioid	NNS
cord-332109-ont0tqpn	466	5	on	on	IN
cord-332109-ont0tqpn	466	6	the	the	DT
cord-332109-ont0tqpn	466	7	endocrine	endocrine	NN
cord-332109-ont0tqpn	466	8	system	system	NN
cord-332109-ont0tqpn	466	9	Opioids	opioid	NNS
cord-332109-ont0tqpn	466	10	and	and	CC
cord-332109-ont0tqpn	466	11	the	the	DT
cord-332109-ont0tqpn	466	12	immune	immune	JJ
cord-332109-ont0tqpn	466	13	system	system	NN
cord-332109-ont0tqpn	466	14	-	-	:
cord-332109-ont0tqpn	466	15	Friend	friend	NN
cord-332109-ont0tqpn	466	16	or	or	CC
cord-332109-ont0tqpn	466	17	foe	foe	NN
cord-332109-ont0tqpn	466	18	The	the	DT
cord-332109-ont0tqpn	466	19	endogenous	endogenous	JJ
cord-332109-ont0tqpn	466	20	opioid	opioid	NN
cord-332109-ont0tqpn	466	21	system	system	NN
cord-332109-ont0tqpn	466	22	and	and	CC
cord-332109-ont0tqpn	466	23	clinical	clinical	JJ
cord-332109-ont0tqpn	466	24	pain	pain	NN
cord-332109-ont0tqpn	466	25	management	management	NN
cord-332109-ont0tqpn	467	1	The	the	DT
cord-332109-ont0tqpn	467	2	endogenous	endogenous	JJ
cord-332109-ont0tqpn	467	3	opioid	opioid	NN
cord-332109-ont0tqpn	467	4	system	system	NN
cord-332109-ont0tqpn	467	5	:	:	:
cord-332109-ont0tqpn	468	1	A	a	DT
cord-332109-ont0tqpn	468	2	common	common	JJ
cord-332109-ont0tqpn	468	3	substrate	substrate	NN
cord-332109-ont0tqpn	468	4	in	in	IN
cord-332109-ont0tqpn	468	5	drug	drug	NN
cord-332109-ont0tqpn	468	6	addiction	addiction	NN
cord-332109-ont0tqpn	468	7	Chronic	Chronic	NNP
cord-332109-ont0tqpn	468	8	morphine	morphine	NN
cord-332109-ont0tqpn	468	9	potentiates	potentiate	VBZ
cord-332109-ont0tqpn	468	10	the	the	DT
cord-332109-ont0tqpn	468	11	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	468	12	response	response	NN
cord-332109-ont0tqpn	468	13	by	by	IN
cord-332109-ont0tqpn	468	14	disrupting	disrupt	VBG
cord-332109-ont0tqpn	468	15	interleukin-1beta	interleukin-1beta	JJ
cord-332109-ont0tqpn	468	16	modulation	modulation	NN
cord-332109-ont0tqpn	468	17	of	of	IN
cord-332109-ont0tqpn	468	18	the	the	DT
cord-332109-ont0tqpn	468	19	hypothalamic	hypothalamic	JJ
cord-332109-ont0tqpn	468	20	-	-	HYPH
cord-332109-ont0tqpn	468	21	pituitary	pituitary	NN
cord-332109-ont0tqpn	468	22	-	-	HYPH
cord-332109-ont0tqpn	468	23	adrenal	adrenal	NN
cord-332109-ont0tqpn	468	24	axis	axis	NN
cord-332109-ont0tqpn	468	25	Chronic	Chronic	NNP
cord-332109-ont0tqpn	468	26	morphine	morphine	NN
cord-332109-ont0tqpn	468	27	accelerates	accelerate	VBZ
cord-332109-ont0tqpn	468	28	the	the	DT
cord-332109-ont0tqpn	468	29	progression	progression	NN
cord-332109-ont0tqpn	468	30	of	of	IN
cord-332109-ont0tqpn	468	31	lipopolysaccharide	lipopolysaccharide	NN
cord-332109-ont0tqpn	468	32	-	-	HYPH
cord-332109-ont0tqpn	468	33	induced	induce	VBN
cord-332109-ont0tqpn	468	34	sepsis	sepsis	NN
cord-332109-ont0tqpn	468	35	to	to	IN
cord-332109-ont0tqpn	468	36	septic	septic	JJ
cord-332109-ont0tqpn	468	37	shock	shock	NN
cord-332109-ont0tqpn	468	38	Crack	crack	NN
cord-332109-ont0tqpn	468	39	whips	whip	VBZ
cord-332109-ont0tqpn	468	40	the	the	DT
cord-332109-ont0tqpn	468	41	heart	heart	NN
cord-332109-ont0tqpn	468	42	:	:	:
cord-332109-ont0tqpn	469	1	A	a	DT
cord-332109-ont0tqpn	469	2	review	review	NN
cord-332109-ont0tqpn	469	3	of	of	IN
cord-332109-ont0tqpn	469	4	the	the	DT
cord-332109-ont0tqpn	469	5	cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	469	6	toxicity	toxicity	NN
cord-332109-ont0tqpn	469	7	of	of	IN
cord-332109-ont0tqpn	469	8	cocaine	cocaine	NN
cord-332109-ont0tqpn	469	9	Cocaine	cocaine	NN
cord-332109-ont0tqpn	469	10	cardiotoxicity	cardiotoxicity	NN
cord-332109-ont0tqpn	469	11	:	:	:
cord-332109-ont0tqpn	469	12	A	a	DT
cord-332109-ont0tqpn	469	13	review	review	NN
cord-332109-ont0tqpn	469	14	of	of	IN
cord-332109-ont0tqpn	469	15	the	the	DT
cord-332109-ont0tqpn	469	16	pathophysiology	pathophysiology	NN
cord-332109-ont0tqpn	469	17	,	,	,
cord-332109-ont0tqpn	469	18	pathology	pathology	NN
cord-332109-ont0tqpn	469	19	,	,	,
cord-332109-ont0tqpn	469	20	and	and	CC
cord-332109-ont0tqpn	469	21	treatment	treatment	NN
cord-332109-ont0tqpn	469	22	options	option	NNS
cord-332109-ont0tqpn	469	23	Cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	469	24	effects	effect	NNS
cord-332109-ont0tqpn	469	25	of	of	IN
cord-332109-ont0tqpn	469	26	cocaine	cocaine	NN
cord-332109-ont0tqpn	469	27	Cocaine	cocaine	NN
cord-332109-ont0tqpn	469	28	Cardiac	Cardiac	NNP
cord-332109-ont0tqpn	469	29	Toxicity	toxicity	NN
cord-332109-ont0tqpn	469	30	:	:	:
cord-332109-ont0tqpn	469	31	Revisited	Revisited	NNP
cord-332109-ont0tqpn	469	32	Cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	469	33	and	and	CC
cord-332109-ont0tqpn	469	34	Hepatic	hepatic	JJ
cord-332109-ont0tqpn	469	35	Toxicity	toxicity	NN
cord-332109-ont0tqpn	469	36	of	of	IN
cord-332109-ont0tqpn	469	37	Cocaine	cocaine	NN
cord-332109-ont0tqpn	469	38	:	:	:
cord-332109-ont0tqpn	469	39	Potential	potential	JJ
cord-332109-ont0tqpn	469	40	Beneficial	beneficial	JJ
cord-332109-ont0tqpn	469	41	Effects	effect	NNS
cord-332109-ont0tqpn	469	42	of	of	IN
cord-332109-ont0tqpn	469	43	Modulators	Modulators	NNPS
cord-332109-ont0tqpn	469	44	of	of	IN
cord-332109-ont0tqpn	469	45	Oxidative	Oxidative	NNP
cord-332109-ont0tqpn	469	46	Stress	Stress	NNP
cord-332109-ont0tqpn	469	47	Management	Management	NNP
cord-332109-ont0tqpn	469	48	of	of	IN
cord-332109-ont0tqpn	469	49	cocaine	cocaine	NN
cord-332109-ont0tqpn	469	50	-	-	HYPH
cord-332109-ont0tqpn	469	51	induced	induce	VBN
cord-332109-ont0tqpn	469	52	cardiac	cardiac	NN
cord-332109-ont0tqpn	469	53	arrhythmias	arrhythmia	NNS
cord-332109-ont0tqpn	469	54	due	due	JJ
cord-332109-ont0tqpn	469	55	to	to	IN
cord-332109-ont0tqpn	469	56	cardiac	cardiac	JJ
cord-332109-ont0tqpn	469	57	ion	ion	NN
cord-332109-ont0tqpn	469	58	channel	channel	NN
cord-332109-ont0tqpn	469	59	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	469	60	History	history	NN
cord-332109-ont0tqpn	469	61	of	of	IN
cord-332109-ont0tqpn	469	62	the	the	DT
cord-332109-ont0tqpn	469	63	Development	Development	NNP
cord-332109-ont0tqpn	469	64	and	and	CC
cord-332109-ont0tqpn	469	65	Evolution	Evolution	NNP
cord-332109-ont0tqpn	469	66	of	of	IN
cord-332109-ont0tqpn	469	67	Local	Local	NNP
cord-332109-ont0tqpn	469	68	Anesthesia	Anesthesia	NNP
cord-332109-ont0tqpn	469	69	since	since	IN
cord-332109-ont0tqpn	469	70	the	the	DT
cord-332109-ont0tqpn	469	71	Coca	Coca	NNP
cord-332109-ont0tqpn	469	72	Leaf	Leaf	NNP
cord-332109-ont0tqpn	469	73	Selective	selective	JJ
cord-332109-ont0tqpn	469	74	Potentiation	Potentiation	NNP
cord-332109-ont0tqpn	469	75	of	of	IN
cord-332109-ont0tqpn	469	76	L	L	NNP
cord-332109-ont0tqpn	469	77	-	-	HYPH
cord-332109-ont0tqpn	469	78	Type	Type	NNP
cord-332109-ont0tqpn	469	79	Calcium	Calcium	NNP
cord-332109-ont0tqpn	469	80	Channel	Channel	NNP
cord-332109-ont0tqpn	469	81	Currents	current	NNS
cord-332109-ont0tqpn	469	82	by	by	IN
cord-332109-ont0tqpn	469	83	Cocaine	Cocaine	NNP
cord-332109-ont0tqpn	469	84	in	in	IN
cord-332109-ont0tqpn	469	85	Cardiac	Cardiac	NNP
cord-332109-ont0tqpn	469	86	Myocytes	Myocytes	NNPS
cord-332109-ont0tqpn	470	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	470	2	-	-	HYPH
cord-332109-ont0tqpn	470	3	induced	induce	VBN
cord-332109-ont0tqpn	470	4	coronary	coronary	JJ
cord-332109-ont0tqpn	470	5	-	-	HYPH
cord-332109-ont0tqpn	470	6	artery	artery	NN
cord-332109-ont0tqpn	470	7	vasoconstriction	vasoconstriction	NN
cord-332109-ont0tqpn	470	8	Cardiovascular	cardiovascular	JJ
cord-332109-ont0tqpn	470	9	and	and	CC
cord-332109-ont0tqpn	470	10	subjective	subjective	JJ
cord-332109-ont0tqpn	470	11	effects	effect	NNS
cord-332109-ont0tqpn	470	12	of	of	IN
cord-332109-ont0tqpn	470	13	intravenous	intravenous	JJ
cord-332109-ont0tqpn	470	14	cocaine	cocaine	NN
cord-332109-ont0tqpn	470	15	administration	administration	NN
cord-332109-ont0tqpn	470	16	in	in	IN
cord-332109-ont0tqpn	470	17	humans	human	NNS
cord-332109-ont0tqpn	470	18	Effect	Effect	NNP
cord-332109-ont0tqpn	470	19	of	of	IN
cord-332109-ont0tqpn	470	20	cocaine	cocaine	NN
cord-332109-ont0tqpn	470	21	on	on	IN
cord-332109-ont0tqpn	470	22	coronary	coronary	JJ
cord-332109-ont0tqpn	470	23	artery	artery	NN
cord-332109-ont0tqpn	470	24	dimensions	dimension	NNS
cord-332109-ont0tqpn	470	25	in	in	IN
cord-332109-ont0tqpn	470	26	atherosclerotic	atherosclerotic	JJ
cord-332109-ont0tqpn	470	27	coronary	coronary	JJ
cord-332109-ont0tqpn	470	28	artery	artery	NN
cord-332109-ont0tqpn	470	29	disease	disease	NN
cord-332109-ont0tqpn	470	30	:	:	:
cord-332109-ont0tqpn	471	1	Enhanced	enhanced	JJ
cord-332109-ont0tqpn	471	2	vasoconstriction	vasoconstriction	NN
cord-332109-ont0tqpn	471	3	at	at	IN
cord-332109-ont0tqpn	471	4	sites	site	NNS
cord-332109-ont0tqpn	471	5	of	of	IN
cord-332109-ont0tqpn	471	6	significant	significant	JJ
cord-332109-ont0tqpn	471	7	stenoses	stenosis	NNS
cord-332109-ont0tqpn	472	1	Endothelium	endothelium	NN
cord-332109-ont0tqpn	472	2	-	-	HYPH
cord-332109-ont0tqpn	472	3	dependent	dependent	JJ
cord-332109-ont0tqpn	472	4	vasorelaxation	vasorelaxation	NN
cord-332109-ont0tqpn	472	5	is	be	VBZ
cord-332109-ont0tqpn	472	6	impaired	impair	VBN
cord-332109-ont0tqpn	472	7	in	in	IN
cord-332109-ont0tqpn	472	8	cocaine	cocaine	NN
cord-332109-ont0tqpn	472	9	arteriopathy	arteriopathy	IN
cord-332109-ont0tqpn	472	10	Endothelial	endothelial	JJ
cord-332109-ont0tqpn	472	11	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	472	12	leads	lead	VBZ
cord-332109-ont0tqpn	472	13	to	to	IN
cord-332109-ont0tqpn	472	14	increased	increase	VBN
cord-332109-ont0tqpn	472	15	coronary	coronary	JJ
cord-332109-ont0tqpn	472	16	constriction	constriction	NN
cord-332109-ont0tqpn	472	17	to	to	IN
cord-332109-ont0tqpn	472	18	catecholamines	catecholamine	NNS
cord-332109-ont0tqpn	472	19	in	in	IN
cord-332109-ont0tqpn	472	20	patients	patient	NNS
cord-332109-ont0tqpn	472	21	with	with	IN
cord-332109-ont0tqpn	472	22	early	early	JJ
cord-332109-ont0tqpn	472	23	atherosclerosis	atherosclerosis	NN
cord-332109-ont0tqpn	472	24	Increased	increase	VBD
cord-332109-ont0tqpn	472	25	TIMI	TIMI	NNP
cord-332109-ont0tqpn	472	26	frame	frame	NN
cord-332109-ont0tqpn	472	27	counts	count	VBZ
cord-332109-ont0tqpn	472	28	in	in	IN
cord-332109-ont0tqpn	472	29	cocaine	cocaine	NN
cord-332109-ont0tqpn	472	30	users	user	NNS
cord-332109-ont0tqpn	472	31	:	:	:
cord-332109-ont0tqpn	472	32	A	a	DT
cord-332109-ont0tqpn	472	33	case	case	NN
cord-332109-ont0tqpn	472	34	for	for	IN
cord-332109-ont0tqpn	472	35	increased	increase	VBN
cord-332109-ont0tqpn	472	36	microvascular	microvascular	JJ
cord-332109-ont0tqpn	472	37	resistance	resistance	NN
cord-332109-ont0tqpn	472	38	in	in	IN
cord-332109-ont0tqpn	472	39	the	the	DT
cord-332109-ont0tqpn	472	40	absence	absence	NN
cord-332109-ont0tqpn	472	41	of	of	IN
cord-332109-ont0tqpn	472	42	epicardial	epicardial	JJ
cord-332109-ont0tqpn	472	43	coronary	coronary	JJ
cord-332109-ont0tqpn	472	44	disease	disease	NN
cord-332109-ont0tqpn	472	45	or	or	CC
cord-332109-ont0tqpn	472	46	spasm	spasm	VB
cord-332109-ont0tqpn	472	47	Quantitative	quantitative	JJ
cord-332109-ont0tqpn	472	48	comparison	comparison	NN
cord-332109-ont0tqpn	472	49	of	of	IN
cord-332109-ont0tqpn	472	50	coronary	coronary	JJ
cord-332109-ont0tqpn	472	51	artery	artery	NN
cord-332109-ont0tqpn	472	52	flow	flow	NN
cord-332109-ont0tqpn	472	53	and	and	CC
cord-332109-ont0tqpn	472	54	myocardial	myocardial	JJ
cord-332109-ont0tqpn	472	55	perfusion	perfusion	NN
cord-332109-ont0tqpn	472	56	in	in	IN
cord-332109-ont0tqpn	472	57	patients	patient	NNS
cord-332109-ont0tqpn	472	58	with	with	IN
cord-332109-ont0tqpn	472	59	acute	acute	JJ
cord-332109-ont0tqpn	472	60	myocardial	myocardial	JJ
cord-332109-ont0tqpn	472	61	infarction	infarction	NN
cord-332109-ont0tqpn	472	62	in	in	IN
cord-332109-ont0tqpn	472	63	the	the	DT
cord-332109-ont0tqpn	472	64	presence	presence	NN
cord-332109-ont0tqpn	472	65	and	and	CC
cord-332109-ont0tqpn	472	66	absence	absence	NN
cord-332109-ont0tqpn	472	67	of	of	IN
cord-332109-ont0tqpn	472	68	recent	recent	JJ
cord-332109-ont0tqpn	472	69	cocaine	cocaine	NN
cord-332109-ont0tqpn	472	70	use	use	VBP
cord-332109-ont0tqpn	472	71	Cocaine	cocaine	NN
cord-332109-ont0tqpn	472	72	receptors	receptor	NNS
cord-332109-ont0tqpn	472	73	on	on	IN
cord-332109-ont0tqpn	472	74	dopamine	dopamine	NN
cord-332109-ont0tqpn	472	75	transporters	transporter	NNS
cord-332109-ont0tqpn	473	1	are	be	VBP
cord-332109-ont0tqpn	473	2	related	relate	VBN
cord-332109-ont0tqpn	473	3	to	to	IN
cord-332109-ont0tqpn	473	4	self	self	NN
cord-332109-ont0tqpn	473	5	-	-	HYPH
cord-332109-ont0tqpn	473	6	administration	administration	NN
cord-332109-ont0tqpn	473	7	of	of	IN
cord-332109-ont0tqpn	473	8	cocaine	cocaine	NN
cord-332109-ont0tqpn	473	9	Cocaine	Cocaine	NNP
cord-332109-ont0tqpn	473	10	inhibits	inhibit	VBZ
cord-332109-ont0tqpn	473	11	muscarinic	muscarinic	JJ
cord-332109-ont0tqpn	473	12	cholinergic	cholinergic	JJ
cord-332109-ont0tqpn	473	13	receptors	receptor	NNS
cord-332109-ont0tqpn	473	14	in	in	IN
cord-332109-ont0tqpn	473	15	heart	heart	NN
cord-332109-ont0tqpn	473	16	and	and	CC
cord-332109-ont0tqpn	473	17	brain	brain	NN
cord-332109-ont0tqpn	473	18	Interactions	interaction	NNS
cord-332109-ont0tqpn	473	19	of	of	IN
cord-332109-ont0tqpn	473	20	cocaine	cocaine	NN
cord-332109-ont0tqpn	473	21	with	with	IN
cord-332109-ont0tqpn	473	22	primary	primary	JJ
cord-332109-ont0tqpn	473	23	and	and	CC
cord-332109-ont0tqpn	473	24	secondary	secondary	JJ
cord-332109-ont0tqpn	473	25	recognition	recognition	NN
cord-332109-ont0tqpn	473	26	sites	site	NNS
cord-332109-ont0tqpn	473	27	on	on	IN
cord-332109-ont0tqpn	473	28	muscarinic	muscarinic	JJ
cord-332109-ont0tqpn	473	29	receptors	receptor	NNS
cord-332109-ont0tqpn	473	30	Cocaine	cocaine	NN
cord-332109-ont0tqpn	473	31	binding	bind	VBG
cord-332109-ont0tqpn	473	32	at	at	IN
cord-332109-ont0tqpn	473	33	sigma	sigma	NNP
cord-332109-ont0tqpn	473	34	receptors	receptor	NNS
cord-332109-ont0tqpn	474	1	The	the	DT
cord-332109-ont0tqpn	474	2	HPA	HPA	NNP
cord-332109-ont0tqpn	474	3	axis	axis	NN
cord-332109-ont0tqpn	474	4	and	and	CC
cord-332109-ont0tqpn	474	5	cocaine	cocaine	NN
cord-332109-ont0tqpn	474	6	reinforcement	reinforcement	NN
cord-332109-ont0tqpn	475	1	Diminished	diminished	NN
cord-332109-ont0tqpn	475	2	interleukin-6	interleukin-6	NNP
cord-332109-ont0tqpn	475	3	response	response	NN
cord-332109-ont0tqpn	475	4	to	to	IN
cord-332109-ont0tqpn	475	5	proinflammatory	proinflammatory	JJ
cord-332109-ont0tqpn	475	6	challenge	challenge	NN
cord-332109-ont0tqpn	475	7	in	in	IN
cord-332109-ont0tqpn	475	8	men	man	NNS
cord-332109-ont0tqpn	475	9	and	and	CC
cord-332109-ont0tqpn	475	10	women	woman	NNS
cord-332109-ont0tqpn	475	11	after	after	IN
cord-332109-ont0tqpn	475	12	intravenous	intravenous	JJ
cord-332109-ont0tqpn	475	13	cocaine	cocaine	NN
cord-332109-ont0tqpn	475	14	administration	administration	NN
cord-332109-ont0tqpn	475	15	Brain	Brain	NNP
cord-332109-ont0tqpn	475	16	capillary	capillary	JJ
cord-332109-ont0tqpn	475	17	lesions	lesion	NNS
cord-332109-ont0tqpn	475	18	produced	produce	VBN
cord-332109-ont0tqpn	475	19	by	by	IN
cord-332109-ont0tqpn	475	20	cocaine	cocaine	NN
cord-332109-ont0tqpn	475	21	in	in	IN
cord-332109-ont0tqpn	475	22	rats	rat	NNS
cord-332109-ont0tqpn	475	23	Chapter	Chapter	NNP
cord-332109-ont0tqpn	475	24	11-Cocaine	11-cocaine	CD
cord-332109-ont0tqpn	476	1	-Induced	-Induced	NNP
cord-332109-ont0tqpn	476	2	Breakdown	Breakdown	NNP
cord-332109-ont0tqpn	476	3	of	of	IN
cord-332109-ont0tqpn	476	4	the	the	DT
cord-332109-ont0tqpn	476	5	Blood	Blood	NNP
cord-332109-ont0tqpn	476	6	-	-	HYPH
cord-332109-ont0tqpn	476	7	Brain	Brain	NNP
cord-332109-ont0tqpn	476	8	Barrier	Barrier	NNP
cord-332109-ont0tqpn	476	9	and	and	CC
cord-332109-ont0tqpn	476	10	Neurotoxicity	Neurotoxicity	NNP
cord-332109-ont0tqpn	476	11	Cocaine	cocaine	NN
cord-332109-ont0tqpn	476	12	Potentiates	Potentiates	NNP
cord-332109-ont0tqpn	476	13	Astrocyte	Astrocyte	NNP
cord-332109-ont0tqpn	476	14	Toxicity	toxicity	NN
cord-332109-ont0tqpn	476	15	Mediated	mediate	VBN
cord-332109-ont0tqpn	476	16	by	by	IN
cord-332109-ont0tqpn	476	17	Human	Human	NNP
cord-332109-ont0tqpn	476	18	Immunodeficiency	Immunodeficiency	NNP
cord-332109-ont0tqpn	476	19	Virus	Virus	NNP
cord-332109-ont0tqpn	476	20	(	(	-LRB-
cord-332109-ont0tqpn	476	21	HIV-1	HIV-1	NNP
cord-332109-ont0tqpn	476	22	)	)	-RRB-
cord-332109-ont0tqpn	477	1	Protein	protein	NN
cord-332109-ont0tqpn	478	1	gp120	gp120	DT
cord-332109-ont0tqpn	478	2	Cocaine	cocaine	NN
cord-332109-ont0tqpn	478	3	Hijacks	hijack	VBZ
cord-332109-ont0tqpn	478	4	σ1	σ1	NNP
cord-332109-ont0tqpn	478	5	Receptor	Receptor	NNP
cord-332109-ont0tqpn	478	6	to	to	TO
cord-332109-ont0tqpn	478	7	Initiate	initiate	VB
cord-332109-ont0tqpn	478	8	Induction	Induction	NNP
cord-332109-ont0tqpn	478	9	of	of	IN
cord-332109-ont0tqpn	478	10	Activated	Activated	NNP
cord-332109-ont0tqpn	478	11	Leukocyte	Leukocyte	NNP
cord-332109-ont0tqpn	478	12	Cell	Cell	NNP
cord-332109-ont0tqpn	478	13	Adhesion	Adhesion	NNP
cord-332109-ont0tqpn	478	14	Molecule	Molecule	NNP
cord-332109-ont0tqpn	478	15	:	:	:
cord-332109-ont0tqpn	479	1	Implication	implication	NN
cord-332109-ont0tqpn	479	2	for	for	IN
cord-332109-ont0tqpn	479	3	Increased	Increased	NNP
cord-332109-ont0tqpn	479	4	Monocyte	Monocyte	NNP
cord-332109-ont0tqpn	479	5	Adhesion	Adhesion	NNP
cord-332109-ont0tqpn	479	6	and	and	CC
cord-332109-ont0tqpn	479	7	Migration	migration	NN
cord-332109-ont0tqpn	479	8	in	in	IN
cord-332109-ont0tqpn	479	9	the	the	DT
cord-332109-ont0tqpn	479	10	CNS	CNS	NNP
cord-332109-ont0tqpn	479	11	Cocaine	Cocaine	NNP
cord-332109-ont0tqpn	479	12	increases	increase	VBZ
cord-332109-ont0tqpn	479	13	human	human	JJ
cord-332109-ont0tqpn	479	14	immunodeficiency	immunodeficiency	NN
cord-332109-ont0tqpn	479	15	virus	virus	NN
cord-332109-ont0tqpn	479	16	type	type	NN
cord-332109-ont0tqpn	479	17	1	1	CD
cord-332109-ont0tqpn	479	18	neuroinvasion	neuroinvasion	NN
cord-332109-ont0tqpn	479	19	through	through	IN
cord-332109-ont0tqpn	479	20	remodeling	remodel	VBG
cord-332109-ont0tqpn	479	21	brain	brain	NN
cord-332109-ont0tqpn	479	22	microvascular	microvascular	JJ
cord-332109-ont0tqpn	479	23	endothelial	endothelial	JJ
cord-332109-ont0tqpn	479	24	cells	cell	NNS
cord-332109-ont0tqpn	480	1	Cocaine	cocaine	NN
cord-332109-ont0tqpn	480	2	-	-	HYPH
cord-332109-ont0tqpn	480	3	mediated	mediate	VBN
cord-332109-ont0tqpn	480	4	Alteration	alteration	NN
cord-332109-ont0tqpn	480	5	in	in	IN
cord-332109-ont0tqpn	480	6	Tight	Tight	NNP
cord-332109-ont0tqpn	480	7	Junction	Junction	NNP
cord-332109-ont0tqpn	480	8	Protein	Protein	NNP
cord-332109-ont0tqpn	480	9	Expression	Expression	NNP
cord-332109-ont0tqpn	480	10	and	and	CC
cord-332109-ont0tqpn	480	11	Modulation	Modulation	NNP
cord-332109-ont0tqpn	480	12	of	of	IN
cord-332109-ont0tqpn	480	13	CCL2	CCL2	NNP
cord-332109-ont0tqpn	480	14	/	/	SYM
cord-332109-ont0tqpn	480	15	CCR2	CCR2	NNP
cord-332109-ont0tqpn	480	16	Axis	Axis	NNP
cord-332109-ont0tqpn	481	1	Across	across	IN
cord-332109-ont0tqpn	481	2	the	the	DT
cord-332109-ont0tqpn	481	3	Blood	Blood	NNP
cord-332109-ont0tqpn	481	4	-	-	HYPH
cord-332109-ont0tqpn	481	5	Brain	Brain	NNP
cord-332109-ont0tqpn	481	6	Barrier	Barrier	NNP
cord-332109-ont0tqpn	481	7	:	:	:
cord-332109-ont0tqpn	481	8	Implications	implication	NNS
cord-332109-ont0tqpn	481	9	for	for	IN
cord-332109-ont0tqpn	481	10	HIV	HIV	NNP
cord-332109-ont0tqpn	481	11	-	-	HYPH
cord-332109-ont0tqpn	481	12	Dementia	Dementia	NNP
cord-332109-ont0tqpn	481	13	Interactive	interactive	JJ
cord-332109-ont0tqpn	481	14	role	role	NN
cord-332109-ont0tqpn	481	15	of	of	IN
cord-332109-ont0tqpn	481	16	human	human	JJ
cord-332109-ont0tqpn	481	17	immunodeficiency	immunodeficiency	NN
cord-332109-ont0tqpn	481	18	virus	virus	NN
cord-332109-ont0tqpn	481	19	type	type	NN
cord-332109-ont0tqpn	481	20	1	1	CD
cord-332109-ont0tqpn	481	21	(	(	-LRB-
cord-332109-ont0tqpn	481	22	HIV-1	HIV-1	NNP
cord-332109-ont0tqpn	481	23	)	)	-RRB-
cord-332109-ont0tqpn	481	24	clade	clade	NN
cord-332109-ont0tqpn	481	25	-	-	HYPH
cord-332109-ont0tqpn	481	26	specific	specific	JJ
cord-332109-ont0tqpn	481	27	Tat	Tat	NNP
cord-332109-ont0tqpn	481	28	protein	protein	NN
cord-332109-ont0tqpn	481	29	and	and	CC
cord-332109-ont0tqpn	481	30	cocaine	cocaine	NN
cord-332109-ont0tqpn	481	31	in	in	IN
cord-332109-ont0tqpn	481	32	blood	blood	NN
cord-332109-ont0tqpn	481	33	-	-	HYPH
cord-332109-ont0tqpn	481	34	brain	brain	NN
cord-332109-ont0tqpn	481	35	barrier	barrier	NN
cord-332109-ont0tqpn	481	36	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	481	37	:	:	:
cord-332109-ont0tqpn	481	38	Implications	implication	NNS
cord-332109-ont0tqpn	481	39	for	for	IN
cord-332109-ont0tqpn	481	40	HIV-1-associated	hiv-1-associate	VBN
cord-332109-ont0tqpn	481	41	neurocognitive	neurocognitive	JJ
cord-332109-ont0tqpn	481	42	disorder	disorder	NN
cord-332109-ont0tqpn	481	43	Cocaine	cocaine	NN
cord-332109-ont0tqpn	481	44	activates	activate	VBZ
cord-332109-ont0tqpn	481	45	redox	redox	NN
cord-332109-ont0tqpn	481	46	-	-	HYPH
cord-332109-ont0tqpn	481	47	regulated	regulate	VBN
cord-332109-ont0tqpn	481	48	transcription	transcription	NN
cord-332109-ont0tqpn	481	49	factors	factor	NNS
cord-332109-ont0tqpn	481	50	and	and	CC
cord-332109-ont0tqpn	481	51	induces	induce	VBZ
cord-332109-ont0tqpn	481	52	TNF	tnf	NN
cord-332109-ont0tqpn	481	53	-	-	HYPH
cord-332109-ont0tqpn	481	54	alpha	alpha	NN
cord-332109-ont0tqpn	481	55	expression	expression	NN
cord-332109-ont0tqpn	481	56	in	in	IN
cord-332109-ont0tqpn	481	57	human	human	JJ
cord-332109-ont0tqpn	481	58	brain	brain	NN
cord-332109-ont0tqpn	481	59	endothelial	endothelial	NN
cord-332109-ont0tqpn	481	60	cells	cell	NNS
cord-332109-ont0tqpn	481	61	Chapter	chapter	NN
cord-332109-ont0tqpn	481	62	5-Molecular	5-molecular	CD
cord-332109-ont0tqpn	481	63	Bases	basis	NNS
cord-332109-ont0tqpn	481	64	of	of	IN
cord-332109-ont0tqpn	481	65	Methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	481	66	-	-	HYPH
cord-332109-ont0tqpn	481	67	Induced	Induced	NNP
cord-332109-ont0tqpn	481	68	Neurodegeneration	Neurodegeneration	NNP
cord-332109-ont0tqpn	481	69	Interactions	Interactions	NNPS
cord-332109-ont0tqpn	481	70	of	of	IN
cord-332109-ont0tqpn	481	71	HIV	HIV	NNP
cord-332109-ont0tqpn	481	72	and	and	CC
cord-332109-ont0tqpn	481	73	Methamphetamine	Methamphetamine	NNP
cord-332109-ont0tqpn	481	74	:	:	:
cord-332109-ont0tqpn	482	1	Cellular	cellular	JJ
cord-332109-ont0tqpn	482	2	and	and	CC
cord-332109-ont0tqpn	482	3	Molecular	Molecular	NNP
cord-332109-ont0tqpn	482	4	Mechanisms	Mechanisms	NNPS
cord-332109-ont0tqpn	482	5	of	of	IN
cord-332109-ont0tqpn	482	6	Toxicity	Toxicity	NNP
cord-332109-ont0tqpn	482	7	Potentiation	Potentiation	NNP
cord-332109-ont0tqpn	482	8	Association	Association	NNP
cord-332109-ont0tqpn	482	9	of	of	IN
cord-332109-ont0tqpn	482	10	dopamine	dopamine	NNP
cord-332109-ont0tqpn	482	11	transporter	transporter	NN
cord-332109-ont0tqpn	482	12	loss	loss	NN
cord-332109-ont0tqpn	482	13	in	in	IN
cord-332109-ont0tqpn	482	14	the	the	DT
cord-332109-ont0tqpn	482	15	orbitofrontal	orbitofrontal	JJ
cord-332109-ont0tqpn	482	16	and	and	CC
cord-332109-ont0tqpn	482	17	dorsolateral	dorsolateral	JJ
cord-332109-ont0tqpn	482	18	prefrontal	prefrontal	JJ
cord-332109-ont0tqpn	482	19	cortices	cortex	NNS
cord-332109-ont0tqpn	482	20	with	with	IN
cord-332109-ont0tqpn	482	21	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	482	22	-	-	HYPH
cord-332109-ont0tqpn	482	23	related	relate	VBN
cord-332109-ont0tqpn	482	24	psychiatric	psychiatric	JJ
cord-332109-ont0tqpn	482	25	symptoms	symptom	NNS
cord-332109-ont0tqpn	482	26	Association	Association	NNP
cord-332109-ont0tqpn	482	27	of	of	IN
cord-332109-ont0tqpn	482	28	dopamine	dopamine	NNP
cord-332109-ont0tqpn	482	29	transporter	transporter	NN
cord-332109-ont0tqpn	482	30	reduction	reduction	NN
cord-332109-ont0tqpn	482	31	with	with	IN
cord-332109-ont0tqpn	482	32	psychomotor	psychomotor	JJ
cord-332109-ont0tqpn	482	33	impairment	impairment	NN
cord-332109-ont0tqpn	482	34	in	in	IN
cord-332109-ont0tqpn	482	35	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	482	36	abusers	abuser	NNS
cord-332109-ont0tqpn	482	37	Trafficking	traffic	VBG
cord-332109-ont0tqpn	482	38	of	of	IN
cord-332109-ont0tqpn	482	39	dopamine	dopamine	NN
cord-332109-ont0tqpn	482	40	transporters	transporter	NNS
cord-332109-ont0tqpn	482	41	in	in	IN
cord-332109-ont0tqpn	482	42	psychostimulant	psychostimulant	JJ
cord-332109-ont0tqpn	482	43	actions	action	NNS
cord-332109-ont0tqpn	482	44	Regulation	Regulation	NNP
cord-332109-ont0tqpn	482	45	of	of	IN
cord-332109-ont0tqpn	482	46	dopamine	dopamine	NN
cord-332109-ont0tqpn	482	47	transporter	transporter	NN
cord-332109-ont0tqpn	482	48	trafficking	trafficking	NN
cord-332109-ont0tqpn	482	49	by	by	IN
cord-332109-ont0tqpn	482	50	intracellular	intracellular	JJ
cord-332109-ont0tqpn	482	51	amphetamine	amphetamine	NN
cord-332109-ont0tqpn	482	52	Monoamine	monoamine	NN
cord-332109-ont0tqpn	482	53	transporters	transporter	NNS
cord-332109-ont0tqpn	482	54	and	and	CC
cord-332109-ont0tqpn	482	55	psychostimulant	psychostimulant	JJ
cord-332109-ont0tqpn	482	56	drugs	drug	NNS
cord-332109-ont0tqpn	482	57	Low	low	JJ
cord-332109-ont0tqpn	482	58	level	level	NN
cord-332109-ont0tqpn	482	59	of	of	IN
cord-332109-ont0tqpn	482	60	brain	brain	NN
cord-332109-ont0tqpn	482	61	dopamine	dopamine	NN
cord-332109-ont0tqpn	482	62	D2	D2	NNP
cord-332109-ont0tqpn	482	63	receptors	receptor	NNS
cord-332109-ont0tqpn	482	64	in	in	IN
cord-332109-ont0tqpn	482	65	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	482	66	abusers	abuser	NNS
cord-332109-ont0tqpn	482	67	:	:	:
cord-332109-ont0tqpn	482	68	Association	Association	NNP
cord-332109-ont0tqpn	482	69	with	with	IN
cord-332109-ont0tqpn	482	70	metabolism	metabolism	NN
cord-332109-ont0tqpn	482	71	in	in	IN
cord-332109-ont0tqpn	482	72	the	the	DT
cord-332109-ont0tqpn	482	73	orbitofrontal	orbitofrontal	JJ
cord-332109-ont0tqpn	482	74	cortex	cortex	NNP
cord-332109-ont0tqpn	482	75	Brain	Brain	NNP
cord-332109-ont0tqpn	482	76	serotonin	serotonin	NN
cord-332109-ont0tqpn	482	77	transporter	transporter	NN
cord-332109-ont0tqpn	482	78	density	density	NN
cord-332109-ont0tqpn	482	79	and	and	CC
cord-332109-ont0tqpn	482	80	aggression	aggression	NN
cord-332109-ont0tqpn	482	81	in	in	IN
cord-332109-ont0tqpn	482	82	abstinent	abstinent	JJ
cord-332109-ont0tqpn	482	83	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	482	84	abusers	abuser	NNS
cord-332109-ont0tqpn	483	1	Why	why	WRB
cord-332109-ont0tqpn	483	2	is	be	VBZ
cord-332109-ont0tqpn	483	3	parkinsonism	parkinsonism	NN
cord-332109-ont0tqpn	483	4	not	not	RB
cord-332109-ont0tqpn	483	5	a	a	DT
cord-332109-ont0tqpn	483	6	feature	feature	NN
cord-332109-ont0tqpn	483	7	of	of	IN
cord-332109-ont0tqpn	483	8	human	human	JJ
cord-332109-ont0tqpn	483	9	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	483	10	users	user	NNS
cord-332109-ont0tqpn	483	11	?	?	.
cord-332109-ont0tqpn	484	1	Striatal	Striatal	NNP
cord-332109-ont0tqpn	484	2	dopamine	dopamine	NN
cord-332109-ont0tqpn	484	3	nerve	nerve	NN
cord-332109-ont0tqpn	484	4	terminal	terminal	NN
cord-332109-ont0tqpn	484	5	markers	marker	NNS
cord-332109-ont0tqpn	484	6	in	in	IN
cord-332109-ont0tqpn	484	7	human	human	JJ
cord-332109-ont0tqpn	484	8	,	,	,
cord-332109-ont0tqpn	484	9	chronic	chronic	JJ
cord-332109-ont0tqpn	484	10	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	484	11	users	user	NNS
cord-332109-ont0tqpn	484	12	Mechanisms	Mechanisms	NNPS
cord-332109-ont0tqpn	484	13	of	of	IN
cord-332109-ont0tqpn	484	14	neurotransmitter	neurotransmitter	NN
cord-332109-ont0tqpn	484	15	release	release	NN
cord-332109-ont0tqpn	484	16	by	by	IN
cord-332109-ont0tqpn	484	17	amphetamines	amphetamine	NNS
cord-332109-ont0tqpn	485	1	:	:	:
cord-332109-ont0tqpn	485	2	A	a	DT
cord-332109-ont0tqpn	485	3	review	review	NN
cord-332109-ont0tqpn	485	4	Methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	485	5	-	-	HYPH
cord-332109-ont0tqpn	485	6	associated	associate	VBN
cord-332109-ont0tqpn	485	7	cardiomyopathy	cardiomyopathy	NN
cord-332109-ont0tqpn	485	8	Repeated	repeat	VBD
cord-332109-ont0tqpn	485	9	amphetamine	amphetamine	NN
cord-332109-ont0tqpn	485	10	administration	administration	NN
cord-332109-ont0tqpn	485	11	in	in	IN
cord-332109-ont0tqpn	485	12	rats	rat	NNS
cord-332109-ont0tqpn	485	13	revealed	reveal	VBD
cord-332109-ont0tqpn	485	14	consistency	consistency	NN
cord-332109-ont0tqpn	485	15	across	across	IN
cord-332109-ont0tqpn	485	16	days	day	NNS
cord-332109-ont0tqpn	485	17	and	and	CC
cord-332109-ont0tqpn	485	18	a	a	DT
cord-332109-ont0tqpn	485	19	complete	complete	JJ
cord-332109-ont0tqpn	485	20	dissociation	dissociation	NN
cord-332109-ont0tqpn	485	21	between	between	IN
cord-332109-ont0tqpn	485	22	locomotor	locomotor	NN
cord-332109-ont0tqpn	485	23	and	and	CC
cord-332109-ont0tqpn	485	24	hypothalamic	hypothalamic	JJ
cord-332109-ont0tqpn	485	25	-	-	HYPH
cord-332109-ont0tqpn	485	26	pituitary	pituitary	NN
cord-332109-ont0tqpn	485	27	-	-	HYPH
cord-332109-ont0tqpn	485	28	adrenal	adrenal	NN
cord-332109-ont0tqpn	485	29	axis	axis	NN
cord-332109-ont0tqpn	485	30	effects	effect	NNS
cord-332109-ont0tqpn	485	31	of	of	IN
cord-332109-ont0tqpn	485	32	the	the	DT
cord-332109-ont0tqpn	485	33	drug	drug	NN
cord-332109-ont0tqpn	485	34	Differential	differential	JJ
cord-332109-ont0tqpn	485	35	effects	effect	NNS
cord-332109-ont0tqpn	485	36	of	of	IN
cord-332109-ont0tqpn	485	37	stress	stress	NN
cord-332109-ont0tqpn	485	38	and	and	CC
cord-332109-ont0tqpn	485	39	amphetamine	amphetamine	NN
cord-332109-ont0tqpn	485	40	administration	administration	NN
cord-332109-ont0tqpn	485	41	on	on	IN
cord-332109-ont0tqpn	485	42	Fos	Fos	NNP
cord-332109-ont0tqpn	485	43	-	-	HYPH
cord-332109-ont0tqpn	485	44	like	like	JJ
cord-332109-ont0tqpn	485	45	protein	protein	NN
cord-332109-ont0tqpn	485	46	expression	expression	NN
cord-332109-ont0tqpn	485	47	in	in	IN
cord-332109-ont0tqpn	485	48	corticotropin	corticotropin	NNP
cord-332109-ont0tqpn	485	49	releasing	release	VBG
cord-332109-ont0tqpn	485	50	factor	factor	NN
cord-332109-ont0tqpn	485	51	-	-	HYPH
cord-332109-ont0tqpn	485	52	neurons	neuron	NNS
cord-332109-ont0tqpn	485	53	of	of	IN
cord-332109-ont0tqpn	485	54	the	the	DT
cord-332109-ont0tqpn	485	55	rat	rat	NN
cord-332109-ont0tqpn	485	56	brain	brain	NN
cord-332109-ont0tqpn	485	57	Ontogeny	ontogeny	NN
cord-332109-ont0tqpn	485	58	of	of	IN
cord-332109-ont0tqpn	485	59	the	the	DT
cord-332109-ont0tqpn	485	60	adrenal	adrenal	JJ
cord-332109-ont0tqpn	485	61	response	response	NN
cord-332109-ont0tqpn	485	62	to	to	IN
cord-332109-ont0tqpn	485	63	(	(	-LRB-
cord-332109-ont0tqpn	485	64	+	+	.
cord-332109-ont0tqpn	486	1	)	)	-RRB-
cord-332109-ont0tqpn	486	2	-methamphetamine	-methamphetamine	:
cord-332109-ont0tqpn	486	3	in	in	IN
cord-332109-ont0tqpn	486	4	neonatal	neonatal	JJ
cord-332109-ont0tqpn	486	5	rats	rat	NNS
cord-332109-ont0tqpn	486	6	:	:	:
cord-332109-ont0tqpn	486	7	The	the	DT
cord-332109-ont0tqpn	486	8	effect	effect	NN
cord-332109-ont0tqpn	486	9	of	of	IN
cord-332109-ont0tqpn	486	10	prior	prior	JJ
cord-332109-ont0tqpn	486	11	drug	drug	NN
cord-332109-ont0tqpn	486	12	exposure	exposure	NN
cord-332109-ont0tqpn	486	13	Serotonin	serotonin	NN
cord-332109-ont0tqpn	486	14	2	2	CD
cord-332109-ont0tqpn	486	15	receptor	receptor	NN
cord-332109-ont0tqpn	486	16	modulation	modulation	NN
cord-332109-ont0tqpn	486	17	of	of	IN
cord-332109-ont0tqpn	486	18	hyperthermia	hyperthermia	NN
cord-332109-ont0tqpn	486	19	,	,	,
cord-332109-ont0tqpn	486	20	corticosterone	corticosterone	NN
cord-332109-ont0tqpn	486	21	,	,	,
cord-332109-ont0tqpn	486	22	and	and	CC
cord-332109-ont0tqpn	486	23	hippocampal	hippocampal	JJ
cord-332109-ont0tqpn	486	24	serotonin	serotonin	NN
cord-332109-ont0tqpn	486	25	depletions	depletion	NNS
cord-332109-ont0tqpn	486	26	following	follow	VBG
cord-332109-ont0tqpn	486	27	serial	serial	JJ
cord-332109-ont0tqpn	486	28	exposure	exposure	NN
cord-332109-ont0tqpn	486	29	to	to	IN
cord-332109-ont0tqpn	486	30	chronic	chronic	JJ
cord-332109-ont0tqpn	486	31	stress	stress	NN
cord-332109-ont0tqpn	486	32	and	and	CC
cord-332109-ont0tqpn	486	33	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	486	34	Methamphetamine	Methamphetamine	NNP
cord-332109-ont0tqpn	486	35	and	and	CC
cord-332109-ont0tqpn	486	36	the	the	DT
cord-332109-ont0tqpn	486	37	hypothalamic	hypothalamic	JJ
cord-332109-ont0tqpn	486	38	-	-	HYPH
cord-332109-ont0tqpn	486	39	pituitary	pituitary	NN
cord-332109-ont0tqpn	486	40	-	-	HYPH
cord-332109-ont0tqpn	486	41	adrenal	adrenal	NN
cord-332109-ont0tqpn	486	42	axis	axis	NN
cord-332109-ont0tqpn	486	43	MDMA	MDMA	NNP
cord-332109-ont0tqpn	486	44	,	,	,
cord-332109-ont0tqpn	486	45	cortisol	cortisol	NN
cord-332109-ont0tqpn	486	46	,	,	,
cord-332109-ont0tqpn	486	47	and	and	CC
cord-332109-ont0tqpn	486	48	heightened	heighten	VBD
cord-332109-ont0tqpn	486	49	stress	stress	NN
cord-332109-ont0tqpn	486	50	in	in	IN
cord-332109-ont0tqpn	486	51	recreational	recreational	JJ
cord-332109-ont0tqpn	486	52	ecstasy	ecstasy	NN
cord-332109-ont0tqpn	486	53	users	user	NNS
cord-332109-ont0tqpn	486	54	Brain	Brain	NNP
cord-332109-ont0tqpn	486	55	injury	injury	NN
cord-332109-ont0tqpn	486	56	associated	associate	VBN
cord-332109-ont0tqpn	486	57	with	with	IN
cord-332109-ont0tqpn	486	58	widely	widely	RB
cord-332109-ont0tqpn	486	59	abused	abuse	VBN
cord-332109-ont0tqpn	486	60	amphetamines	amphetamine	NNS
cord-332109-ont0tqpn	486	61	:	:	:
cord-332109-ont0tqpn	486	62	Neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	486	63	,	,	,
cord-332109-ont0tqpn	486	64	neurogenesis	neurogenesis	NN
cord-332109-ont0tqpn	486	65	and	and	CC
cord-332109-ont0tqpn	486	66	blood	blood	NN
cord-332109-ont0tqpn	486	67	-	-	HYPH
cord-332109-ont0tqpn	486	68	brain	brain	NN
cord-332109-ont0tqpn	486	69	barrier	barrier	NN
cord-332109-ont0tqpn	486	70	Delayed	delay	VBD
cord-332109-ont0tqpn	486	71	ischemic	ischemic	JJ
cord-332109-ont0tqpn	486	72	stroke	stroke	NN
cord-332109-ont0tqpn	486	73	associated	associate	VBN
cord-332109-ont0tqpn	486	74	with	with	IN
cord-332109-ont0tqpn	486	75	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	486	76	use	use	NN
cord-332109-ont0tqpn	486	77	Ischemic	ischemic	JJ
cord-332109-ont0tqpn	486	78	stroke	stroke	NN
cord-332109-ont0tqpn	486	79	associated	associate	VBN
cord-332109-ont0tqpn	486	80	with	with	IN
cord-332109-ont0tqpn	486	81	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	486	82	inhalation	inhalation	NN
cord-332109-ont0tqpn	486	83	Methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	486	84	causes	cause	NNS
cord-332109-ont0tqpn	486	85	sustained	sustain	VBD
cord-332109-ont0tqpn	486	86	depression	depression	NN
cord-332109-ont0tqpn	486	87	in	in	IN
cord-332109-ont0tqpn	486	88	cerebral	cerebral	JJ
cord-332109-ont0tqpn	486	89	blood	blood	NN
cord-332109-ont0tqpn	486	90	flow	flow	NN
cord-332109-ont0tqpn	487	1	In	in	IN
cord-332109-ont0tqpn	487	2	vivo	vivo	NN
cord-332109-ont0tqpn	487	3	evidence	evidence	NN
cord-332109-ont0tqpn	487	4	for	for	IN
cord-332109-ont0tqpn	487	5	long	long	JJ
cord-332109-ont0tqpn	487	6	-	-	HYPH
cord-332109-ont0tqpn	487	7	term	term	NN
cord-332109-ont0tqpn	487	8	CNS	CNS	NNP
cord-332109-ont0tqpn	487	9	toxicity	toxicity	NN
cord-332109-ont0tqpn	487	10	,	,	,
cord-332109-ont0tqpn	487	11	associated	associate	VBN
cord-332109-ont0tqpn	487	12	with	with	IN
cord-332109-ont0tqpn	487	13	chronic	chronic	JJ
cord-332109-ont0tqpn	487	14	binge	binge	NN
cord-332109-ont0tqpn	487	15	use	use	NN
cord-332109-ont0tqpn	487	16	of	of	IN
cord-332109-ont0tqpn	487	17	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	487	18	Alteration	alteration	NN
cord-332109-ont0tqpn	487	19	of	of	IN
cord-332109-ont0tqpn	487	20	blood	blood	NN
cord-332109-ont0tqpn	487	21	-	-	HYPH
cord-332109-ont0tqpn	487	22	brain	brain	NN
cord-332109-ont0tqpn	487	23	barrier	barrier	NN
cord-332109-ont0tqpn	487	24	function	function	NN
cord-332109-ont0tqpn	487	25	by	by	IN
cord-332109-ont0tqpn	487	26	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	487	27	and	and	CC
cord-332109-ont0tqpn	487	28	cocaine	cocaine	NN
cord-332109-ont0tqpn	487	29	Methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	487	30	abuse	abuse	NN
cord-332109-ont0tqpn	487	31	,	,	,
cord-332109-ont0tqpn	487	32	HIV	HIV	NNP
cord-332109-ont0tqpn	487	33	infection	infection	NN
cord-332109-ont0tqpn	487	34	,	,	,
cord-332109-ont0tqpn	487	35	and	and	CC
cord-332109-ont0tqpn	487	36	neurotoxicity	neurotoxicity	NN
cord-332109-ont0tqpn	488	1	The	the	DT
cord-332109-ont0tqpn	488	2	blood	blood	NN
cord-332109-ont0tqpn	488	3	-	-	HYPH
cord-332109-ont0tqpn	488	4	brain	brain	NN
cord-332109-ont0tqpn	488	5	barrier	barrier	NN
cord-332109-ont0tqpn	488	6	and	and	CC
cord-332109-ont0tqpn	488	7	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	488	8	:	:	:
cord-332109-ont0tqpn	488	9	Open	open	VB
cord-332109-ont0tqpn	488	10	sesame	sesame	NN
cord-332109-ont0tqpn	488	11	?	?	.
cord-332109-ont0tqpn	489	1	Specific	specific	JJ
cord-332109-ont0tqpn	489	2	gene	gene	NN
cord-332109-ont0tqpn	489	3	expression	expression	NN
cord-332109-ont0tqpn	489	4	and	and	CC
cord-332109-ont0tqpn	489	5	possible	possible	JJ
cord-332109-ont0tqpn	489	6	involvement	involvement	NN
cord-332109-ont0tqpn	489	7	of	of	IN
cord-332109-ont0tqpn	489	8	inflammation	inflammation	NN
cord-332109-ont0tqpn	489	9	in	in	IN
cord-332109-ont0tqpn	489	10	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	489	11	-	-	HYPH
cord-332109-ont0tqpn	489	12	induced	induce	VBN
cord-332109-ont0tqpn	489	13	neurotoxicity	neurotoxicity	NN
cord-332109-ont0tqpn	490	1	The	the	DT
cord-332109-ont0tqpn	490	2	effects	effect	NNS
cord-332109-ont0tqpn	490	3	of	of	IN
cord-332109-ont0tqpn	490	4	psychostimulant	psychostimulant	JJ
cord-332109-ont0tqpn	490	5	drugs	drug	NNS
cord-332109-ont0tqpn	490	6	on	on	IN
cord-332109-ont0tqpn	490	7	blood	blood	NN
cord-332109-ont0tqpn	490	8	brain	brain	NN
cord-332109-ont0tqpn	490	9	barrier	barrier	NN
cord-332109-ont0tqpn	490	10	function	function	NN
cord-332109-ont0tqpn	490	11	and	and	CC
cord-332109-ont0tqpn	490	12	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	490	13	Acceleration	Acceleration	NNP
cord-332109-ont0tqpn	490	14	of	of	IN
cord-332109-ont0tqpn	490	15	HIV	HIV	NNP
cord-332109-ont0tqpn	490	16	dementia	dementia	NN
cord-332109-ont0tqpn	490	17	with	with	IN
cord-332109-ont0tqpn	490	18	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	490	19	and	and	CC
cord-332109-ont0tqpn	490	20	cocaine	cocaine	NN
cord-332109-ont0tqpn	491	1	The	the	DT
cord-332109-ont0tqpn	491	2	effects	effect	NNS
cord-332109-ont0tqpn	491	3	of	of	IN
cord-332109-ont0tqpn	491	4	hepatitis	hepatitis	NN
cord-332109-ont0tqpn	491	5	C	C	NNP
cord-332109-ont0tqpn	491	6	,	,	,
cord-332109-ont0tqpn	491	7	HIV	HIV	NNP
cord-332109-ont0tqpn	491	8	,	,	,
cord-332109-ont0tqpn	491	9	and	and	CC
cord-332109-ont0tqpn	491	10	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	491	11	dependence	dependence	NN
cord-332109-ont0tqpn	491	12	on	on	IN
cord-332109-ont0tqpn	491	13	neuropsychological	neuropsychological	JJ
cord-332109-ont0tqpn	491	14	performance	performance	NN
cord-332109-ont0tqpn	491	15	:	:	:
cord-332109-ont0tqpn	491	16	Biological	biological	JJ
cord-332109-ont0tqpn	491	17	correlates	correlate	NNS
cord-332109-ont0tqpn	491	18	of	of	IN
cord-332109-ont0tqpn	491	19	disease	disease	NN
cord-332109-ont0tqpn	492	1	The	the	DT
cord-332109-ont0tqpn	492	2	clinical	clinical	JJ
cord-332109-ont0tqpn	492	3	toxicology	toxicology	NN
cord-332109-ont0tqpn	492	4	of	of	IN
cord-332109-ont0tqpn	492	5	metamfetamine	metamfetamine	NNP
cord-332109-ont0tqpn	492	6	Acute	Acute	NNP
cord-332109-ont0tqpn	492	7	Administration	Administration	NNP
cord-332109-ont0tqpn	492	8	of	of	IN
cord-332109-ont0tqpn	492	9	3,4-Methylenedioxymethamphetamine	3,4-methylenedioxymethamphetamine	CD
cord-332109-ont0tqpn	493	1	Induces	induce	VBZ
cord-332109-ont0tqpn	493	2	Profound	profound	JJ
cord-332109-ont0tqpn	493	3	Hyperthermia	hyperthermia	NN
cord-332109-ont0tqpn	493	4	,	,	,
cord-332109-ont0tqpn	493	5	Blood	blood	NN
cord-332109-ont0tqpn	493	6	-	-	HYPH
cord-332109-ont0tqpn	493	7	Brain	Brain	NNP
cord-332109-ont0tqpn	493	8	Barrier	Barrier	NNP
cord-332109-ont0tqpn	493	9	Disruption	Disruption	NNP
cord-332109-ont0tqpn	493	10	,	,	,
cord-332109-ont0tqpn	493	11	Brain	Brain	NNP
cord-332109-ont0tqpn	493	12	Edema	Edema	NNP
cord-332109-ont0tqpn	493	13	Formation	Formation	NNP
cord-332109-ont0tqpn	493	14	,	,	,
cord-332109-ont0tqpn	493	15	and	and	CC
cord-332109-ont0tqpn	493	16	Cell	Cell	NNP
cord-332109-ont0tqpn	493	17	Injury	injury	NN
cord-332109-ont0tqpn	494	1	The	the	DT
cord-332109-ont0tqpn	494	2	role	role	NN
cord-332109-ont0tqpn	494	3	of	of	IN
cord-332109-ont0tqpn	494	4	metabolism	metabolism	NN
cord-332109-ont0tqpn	494	5	in	in	IN
cord-332109-ont0tqpn	494	6	3,4-(+)-methylenedioxyamphetamine	3,4-(+)-methylenedioxyamphetamine	NNP
cord-332109-ont0tqpn	494	7	and	and	CC
cord-332109-ont0tqpn	494	8	3,4-(+)-methylenedioxymethamphetamine	3,4-(+)-methylenedioxymethamphetamine	NNP
cord-332109-ont0tqpn	495	1	(	(	-LRB-
cord-332109-ont0tqpn	495	2	ecstasy	ecstasy	NN
cord-332109-ont0tqpn	495	3	)	)	-RRB-
cord-332109-ont0tqpn	495	4	toxicity	toxicity	NN
cord-332109-ont0tqpn	495	5	Methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	495	6	-	-	HYPH
cord-332109-ont0tqpn	495	7	Induced	Induced	NNP
cord-332109-ont0tqpn	495	8	Early	early	JJ
cord-332109-ont0tqpn	495	9	Increase	increase	NN
cord-332109-ont0tqpn	495	10	of	of	IN
cord-332109-ont0tqpn	496	1	IL-6	IL-6	NNP
cord-332109-ont0tqpn	496	2	and	and	CC
cord-332109-ont0tqpn	496	3	TNF	TNF	NNP
cord-332109-ont0tqpn	496	4	-	-	HYPH
cord-332109-ont0tqpn	496	5	α	α	NNP
cord-332109-ont0tqpn	496	6	mRNA	mrna	NN
cord-332109-ont0tqpn	496	7	Expression	expression	NN
cord-332109-ont0tqpn	496	8	in	in	IN
cord-332109-ont0tqpn	496	9	the	the	DT
cord-332109-ont0tqpn	496	10	Mouse	Mouse	NNP
cord-332109-ont0tqpn	496	11	Brain	Brain	NNP
cord-332109-ont0tqpn	496	12	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-332109-ont0tqpn	496	13	mitagates	mitagate	VBZ
cord-332109-ont0tqpn	496	14	methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	496	15	-	-	HYPH
cord-332109-ont0tqpn	496	16	induced	induce	VBN
cord-332109-ont0tqpn	496	17	striatal	striatal	JJ
cord-332109-ont0tqpn	496	18	dopamine	dopamine	NN
cord-332109-ont0tqpn	496	19	depletion	depletion	NN
cord-332109-ont0tqpn	496	20	via	via	IN
cord-332109-ont0tqpn	496	21	modulating	modulate	VBG
cord-332109-ont0tqpn	496	22	local	local	JJ
cord-332109-ont0tqpn	496	23	TNF	TNF	NNP
cord-332109-ont0tqpn	496	24	-	-	HYPH
cord-332109-ont0tqpn	496	25	α	α	NNP
cord-332109-ont0tqpn	496	26	and	and	CC
cord-332109-ont0tqpn	496	27	dopamine	dopamine	NN
cord-332109-ont0tqpn	496	28	transporter	transporter	NN
cord-332109-ont0tqpn	496	29	expression	expression	NN
cord-332109-ont0tqpn	496	30	Methamphetamine	methamphetamine	NN
cord-332109-ont0tqpn	496	31	-	-	HYPH
cord-332109-ont0tqpn	496	32	induced	induce	VBN
cord-332109-ont0tqpn	496	33	neuroinflammation	neuroinflammation	NN
cord-332109-ont0tqpn	496	34	and	and	CC
cord-332109-ont0tqpn	496	35	neuronal	neuronal	JJ
cord-332109-ont0tqpn	496	36	dysfunction	dysfunction	NN
cord-332109-ont0tqpn	496	37	in	in	IN
cord-332109-ont0tqpn	496	38	the	the	DT
cord-332109-ont0tqpn	496	39	mice	mice	NN
cord-332109-ont0tqpn	496	40	hippocampus	hippocampus	NN
cord-332109-ont0tqpn	496	41	:	:	:
cord-332109-ont0tqpn	497	1	Preventive	preventive	JJ
cord-332109-ont0tqpn	497	2	effect	effect	NN
cord-332109-ont0tqpn	497	3	of	of	IN
cord-332109-ont0tqpn	497	4	indomethacin	indomethacin	JJ
cord-332109-ont0tqpn	497	5	Changes	change	NNS
cord-332109-ont0tqpn	497	6	in	in	IN
cord-332109-ont0tqpn	497	7	interleukin-1	interleukin-1	NN
cord-332109-ont0tqpn	497	8	signal	signal	NN
cord-332109-ont0tqpn	497	9	modulators	modulator	NNS
cord-332109-ont0tqpn	497	10	induced	induce	VBN
cord-332109-ont0tqpn	497	11	by	by	IN
cord-332109-ont0tqpn	497	12	3,4-methylenedioxymethamphetamine	3,4-methylenedioxymethamphetamine	NNP
cord-332109-ont0tqpn	497	13	(	(	-LRB-
cord-332109-ont0tqpn	497	14	MDMA	MDMA	NNP
cord-332109-ont0tqpn	497	15	)	)	-RRB-
cord-332109-ont0tqpn	498	1	:	:	:
cord-332109-ont0tqpn	498	2	Regulation	regulation	NN
cord-332109-ont0tqpn	498	3	by	by	IN
cord-332109-ont0tqpn	498	4	CB2	CB2	NNP
cord-332109-ont0tqpn	498	5	receptors	receptor	NNS
cord-332109-ont0tqpn	498	6	and	and	CC
cord-332109-ont0tqpn	498	7	implications	implication	NNS
cord-332109-ont0tqpn	498	8	for	for	IN
cord-332109-ont0tqpn	498	9	neurotoxicity	neurotoxicity	NN
cord-332109-ont0tqpn	498	10	Amphetamine	Amphetamine	NNP
cord-332109-ont0tqpn	498	11	Neurotoxicity	Neurotoxicity	NNP
cord-332109-ont0tqpn	498	12	:	:	:
cord-332109-ont0tqpn	499	1	Cause	cause	VB
cord-332109-ont0tqpn	499	2	and	and	CC
cord-332109-ont0tqpn	499	3	Consequence	consequence	NN
cord-332109-ont0tqpn	499	4	of	of	IN
cord-332109-ont0tqpn	499	5	Oxidative	oxidative	JJ
cord-332109-ont0tqpn	499	6	Stress	stress	NN
cord-332109-ont0tqpn	499	7	Pharmacologic	Pharmacologic	NNP
cord-332109-ont0tqpn	499	8	Treatments	Treatments	NNPS
cord-332109-ont0tqpn	499	9	for	for	IN
cord-332109-ont0tqpn	499	10	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	499	11	Disease	Disease	NNP
cord-332109-ont0tqpn	499	12	2019	2019	CD
cord-332109-ont0tqpn	499	13	(	(	-LRB-
cord-332109-ont0tqpn	499	14	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	499	15	)	)	-RRB-
cord-332109-ont0tqpn	499	16	:	:	:
cord-332109-ont0tqpn	500	1	A	a	DT
cord-332109-ont0tqpn	500	2	Review	Review	NNP
cord-332109-ont0tqpn	500	3	Research	Research	NNP
cord-332109-ont0tqpn	500	4	and	and	CC
cord-332109-ont0tqpn	500	5	Development	Development	NNP
cord-332109-ont0tqpn	500	6	on	on	IN
cord-332109-ont0tqpn	500	7	Therapeutic	therapeutic	JJ
cord-332109-ont0tqpn	500	8	Agents	Agents	NNPS
cord-332109-ont0tqpn	500	9	and	and	CC
cord-332109-ont0tqpn	500	10	Vaccines	Vaccines	NNPS
cord-332109-ont0tqpn	500	11	for	for	IN
cord-332109-ont0tqpn	500	12	COVID-19	covid-19	CD
cord-332109-ont0tqpn	500	13	and	and	CC
cord-332109-ont0tqpn	500	14	Related	Related	NNP
cord-332109-ont0tqpn	500	15	Human	Human	NNP
cord-332109-ont0tqpn	500	16	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	500	17	Diseases	Diseases	NNPS
cord-332109-ont0tqpn	500	18	Network	Network	NNP
cord-332109-ont0tqpn	500	19	-	-	HYPH
cord-332109-ont0tqpn	500	20	based	base	VBN
cord-332109-ont0tqpn	500	21	drug	drug	NN
cord-332109-ont0tqpn	500	22	repurposing	repurpose	VBG
cord-332109-ont0tqpn	500	23	for	for	IN
cord-332109-ont0tqpn	500	24	novel	novel	JJ
cord-332109-ont0tqpn	500	25	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	500	26	2019-nCoV	2019-ncov	CD
cord-332109-ont0tqpn	500	27	/	/	SYM
cord-332109-ont0tqpn	500	28	SARS	SARS	NNP
cord-332109-ont0tqpn	500	29	-	-	HYPH
cord-332109-ont0tqpn	500	30	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	500	31	Clinical	clinical	JJ
cord-332109-ont0tqpn	500	32	efficacy	efficacy	NN
cord-332109-ont0tqpn	500	33	of	of	IN
cord-332109-ont0tqpn	500	34	hydroxychloroquine	hydroxychloroquine	NN
cord-332109-ont0tqpn	500	35	in	in	IN
cord-332109-ont0tqpn	500	36	patients	patient	NNS
cord-332109-ont0tqpn	500	37	with	with	IN
cord-332109-ont0tqpn	500	38	covid-19	covid-19	NNP
cord-332109-ont0tqpn	500	39	pneumonia	pneumonia	NN
cord-332109-ont0tqpn	500	40	who	who	WP
cord-332109-ont0tqpn	500	41	require	require	VBP
cord-332109-ont0tqpn	500	42	oxygen	oxygen	NN
cord-332109-ont0tqpn	500	43	:	:	:
cord-332109-ont0tqpn	501	1	Observational	observational	JJ
cord-332109-ont0tqpn	501	2	comparative	comparative	JJ
cord-332109-ont0tqpn	501	3	study	study	NN
cord-332109-ont0tqpn	501	4	using	use	VBG
cord-332109-ont0tqpn	501	5	routine	routine	JJ
cord-332109-ont0tqpn	501	6	care	care	NN
cord-332109-ont0tqpn	501	7	data	datum	NNS
cord-332109-ont0tqpn	501	8	Remdesivir	Remdesivir	NNP
cord-332109-ont0tqpn	501	9	and	and	CC
cord-332109-ont0tqpn	501	10	chloroquine	chloroquine	NN
cord-332109-ont0tqpn	501	11	effectively	effectively	RB
cord-332109-ont0tqpn	501	12	inhibit	inhibit	VBP
cord-332109-ont0tqpn	501	13	the	the	DT
cord-332109-ont0tqpn	501	14	recently	recently	RB
cord-332109-ont0tqpn	501	15	emerged	emerge	VBN
cord-332109-ont0tqpn	501	16	novel	novel	JJ
cord-332109-ont0tqpn	501	17	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	501	18	(	(	-LRB-
cord-332109-ont0tqpn	501	19	2019-nCoV	2019-ncov	CD
cord-332109-ont0tqpn	501	20	)	)	-RRB-
cord-332109-ont0tqpn	501	21	in	in	IN
cord-332109-ont0tqpn	501	22	vitro	vitro	FW
cord-332109-ont0tqpn	501	23	RETRACTED	retracted	RB
cord-332109-ont0tqpn	501	24	:	:	:
cord-332109-ont0tqpn	502	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-332109-ont0tqpn	502	2	or	or	CC
cord-332109-ont0tqpn	502	3	chloroquine	chloroquine	NN
cord-332109-ont0tqpn	502	4	with	with	IN
cord-332109-ont0tqpn	502	5	or	or	CC
cord-332109-ont0tqpn	502	6	without	without	IN
cord-332109-ont0tqpn	502	7	a	a	DT
cord-332109-ont0tqpn	502	8	macrolide	macrolide	NN
cord-332109-ont0tqpn	502	9	for	for	IN
cord-332109-ont0tqpn	502	10	treatment	treatment	NN
cord-332109-ont0tqpn	502	11	of	of	IN
cord-332109-ont0tqpn	502	12	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	502	13	:	:	:
cord-332109-ont0tqpn	502	14	A	a	DT
cord-332109-ont0tqpn	502	15	multinational	multinational	JJ
cord-332109-ont0tqpn	502	16	registry	registry	NN
cord-332109-ont0tqpn	502	17	analysis	analysis	NN
cord-332109-ont0tqpn	502	18	Clinical	Clinical	NNP
cord-332109-ont0tqpn	502	19	Trial	Trial	NNP
cord-332109-ont0tqpn	502	20	for	for	IN
cord-332109-ont0tqpn	502	21	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	502	22	Treatments	Treatments	NNP
cord-332109-ont0tqpn	502	23	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	502	24	)	)	-RRB-
cord-332109-ont0tqpn	502	25	Update	update	NN
cord-332109-ont0tqpn	502	26	:	:	:
cord-332109-ont0tqpn	502	27	FDA	FDA	NNP
cord-332109-ont0tqpn	502	28	Revokes	revoke	VBZ
cord-332109-ont0tqpn	502	29	Emergency	Emergency	NNP
cord-332109-ont0tqpn	502	30	Use	Use	NNP
cord-332109-ont0tqpn	502	31	Authorization	Authorization	NNP
cord-332109-ont0tqpn	502	32	for	for	IN
cord-332109-ont0tqpn	502	33	Chloroquine	Chloroquine	NNP
cord-332109-ont0tqpn	502	34	and	and	CC
cord-332109-ont0tqpn	502	35	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-332109-ont0tqpn	502	36	Triple	Triple	NNP
cord-332109-ont0tqpn	502	37	combination	combination	NN
cord-332109-ont0tqpn	502	38	of	of	IN
cord-332109-ont0tqpn	502	39	interferon	interferon	NN
cord-332109-ont0tqpn	502	40	beta-1b	beta-1b	NNP
cord-332109-ont0tqpn	502	41	,	,	,
cord-332109-ont0tqpn	502	42	lopinavir	lopinavir	NNS
cord-332109-ont0tqpn	502	43	-	-	HYPH
cord-332109-ont0tqpn	502	44	ritonavir	ritonavir	NNS
cord-332109-ont0tqpn	502	45	,	,	,
cord-332109-ont0tqpn	502	46	and	and	CC
cord-332109-ont0tqpn	502	47	ribavirin	ribavirin	NN
cord-332109-ont0tqpn	502	48	in	in	IN
cord-332109-ont0tqpn	502	49	the	the	DT
cord-332109-ont0tqpn	502	50	treatment	treatment	NN
cord-332109-ont0tqpn	502	51	of	of	IN
cord-332109-ont0tqpn	502	52	patients	patient	NNS
cord-332109-ont0tqpn	502	53	admitted	admit	VBN
cord-332109-ont0tqpn	502	54	to	to	IN
cord-332109-ont0tqpn	502	55	hospital	hospital	NN
cord-332109-ont0tqpn	502	56	with	with	IN
cord-332109-ont0tqpn	502	57	COVID-19	covid-19	NN
cord-332109-ont0tqpn	502	58	:	:	:
cord-332109-ont0tqpn	502	59	An	an	DT
cord-332109-ont0tqpn	502	60	open	open	JJ
cord-332109-ont0tqpn	502	61	-	-	HYPH
cord-332109-ont0tqpn	502	62	label	label	NN
cord-332109-ont0tqpn	502	63	,	,	,
cord-332109-ont0tqpn	502	64	randomised	randomise	VBD
cord-332109-ont0tqpn	502	65	A	a	DT
cord-332109-ont0tqpn	502	66	Trial	Trial	NNP
cord-332109-ont0tqpn	502	67	of	of	IN
cord-332109-ont0tqpn	502	68	Lopinavir	Lopinavir	NNP
cord-332109-ont0tqpn	502	69	-	-	HYPH
cord-332109-ont0tqpn	502	70	Ritonavir	Ritonavir	NNP
cord-332109-ont0tqpn	502	71	in	in	IN
cord-332109-ont0tqpn	502	72	Adults	Adults	NNPS
cord-332109-ont0tqpn	502	73	Hospitalized	hospitalize	VBN
cord-332109-ont0tqpn	502	74	with	with	IN
cord-332109-ont0tqpn	502	75	Severe	severe	JJ
cord-332109-ont0tqpn	502	76	Covid-19	Covid-19	NNP
cord-332109-ont0tqpn	502	77	Novel	Novel	NNP
cord-332109-ont0tqpn	502	78	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	502	79	treatment	treatment	NN
cord-332109-ont0tqpn	502	80	with	with	IN
cord-332109-ont0tqpn	502	81	ribavirin	ribavirin	NN
cord-332109-ont0tqpn	502	82	:	:	:
cord-332109-ont0tqpn	502	83	Groundwork	groundwork	NN
cord-332109-ont0tqpn	502	84	for	for	IN
cord-332109-ont0tqpn	502	85	an	an	DT
cord-332109-ont0tqpn	502	86	evaluation	evaluation	NN
cord-332109-ont0tqpn	502	87	concerning	concern	VBG
cord-332109-ont0tqpn	502	88	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	502	89	Vulnerabilities	Vulnerabilities	NNPS
cord-332109-ont0tqpn	502	90	of	of	IN
cord-332109-ont0tqpn	502	91	the	the	DT
cord-332109-ont0tqpn	502	92	SARS	SARS	NNP
cord-332109-ont0tqpn	502	93	-	-	HYPH
cord-332109-ont0tqpn	502	94	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	502	95	virus	virus	NN
cord-332109-ont0tqpn	502	96	to	to	IN
cord-332109-ont0tqpn	502	97	proteotoxicity	proteotoxicity	NN
cord-332109-ont0tqpn	502	98	-	-	HYPH
cord-332109-ont0tqpn	502	99	Opportunity	opportunity	NN
cord-332109-ont0tqpn	502	100	for	for	IN
cord-332109-ont0tqpn	502	101	repurposed	repurpose	VBN
cord-332109-ont0tqpn	502	102	chemotherapy	chemotherapy	NN
cord-332109-ont0tqpn	502	103	of	of	IN
cord-332109-ont0tqpn	502	104	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	502	105	infection	infection	NN
cord-332109-ont0tqpn	502	106	Efficacy	Efficacy	NNP
cord-332109-ont0tqpn	502	107	and	and	CC
cord-332109-ont0tqpn	502	108	safety	safety	NN
cord-332109-ont0tqpn	502	109	of	of	IN
cord-332109-ont0tqpn	502	110	Lianhuaqingwen	Lianhuaqingwen	NNP
cord-332109-ont0tqpn	502	111	capsules	capsule	NNS
cord-332109-ont0tqpn	502	112	,	,	,
cord-332109-ont0tqpn	502	113	a	a	DT
cord-332109-ont0tqpn	502	114	repurposed	repurpose	VBN
cord-332109-ont0tqpn	502	115	Chinese	chinese	JJ
cord-332109-ont0tqpn	502	116	herb	herb	NN
cord-332109-ont0tqpn	502	117	Broad	Broad	NNP
cord-332109-ont0tqpn	502	118	Spectrum	Spectrum	NNP
cord-332109-ont0tqpn	502	119	Antiviral	Antiviral	NNP
cord-332109-ont0tqpn	502	120	Agent	Agent	NNP
cord-332109-ont0tqpn	502	121	Niclosamide	Niclosamide	NNP
cord-332109-ont0tqpn	502	122	and	and	CC
cord-332109-ont0tqpn	502	123	Its	-PRON-	PRP$
cord-332109-ont0tqpn	502	124	Therapeutic	therapeutic	JJ
cord-332109-ont0tqpn	502	125	Potential	Potential	NNP
cord-332109-ont0tqpn	502	126	Ruxolitinib	Ruxolitinib	NNP
cord-332109-ont0tqpn	502	127	in	in	IN
cord-332109-ont0tqpn	502	128	treatment	treatment	NN
cord-332109-ont0tqpn	502	129	of	of	IN
cord-332109-ont0tqpn	502	130	severe	severe	JJ
cord-332109-ont0tqpn	502	131	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	502	132	disease	disease	NN
cord-332109-ont0tqpn	502	133	2019	2019	CD
cord-332109-ont0tqpn	502	134	(	(	-LRB-
cord-332109-ont0tqpn	502	135	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	502	136	)	)	-RRB-
cord-332109-ont0tqpn	502	137	:	:	:
cord-332109-ont0tqpn	503	1	A	a	DT
cord-332109-ont0tqpn	503	2	multicenter	multicenter	JJ
cord-332109-ont0tqpn	503	3	,	,	,
cord-332109-ont0tqpn	503	4	single	single	JJ
cord-332109-ont0tqpn	503	5	-	-	HYPH
cord-332109-ont0tqpn	503	6	blind	blind	JJ
cord-332109-ont0tqpn	503	7	,	,	,
cord-332109-ont0tqpn	503	8	randomized	randomized	JJ
cord-332109-ont0tqpn	503	9	controlled	control	VBN
cord-332109-ont0tqpn	503	10	trial	trial	NN
cord-332109-ont0tqpn	503	11	Favipiravir	Favipiravir	NNP
cord-332109-ont0tqpn	503	12	,	,	,
cord-332109-ont0tqpn	503	13	an	an	DT
cord-332109-ont0tqpn	503	14	antiviral	antiviral	JJ
cord-332109-ont0tqpn	503	15	for	for	IN
cord-332109-ont0tqpn	503	16	COVID-19	covid-19	NN
cord-332109-ont0tqpn	503	17	?	?	.
cord-332109-ont0tqpn	504	1	Remdesivir	Remdesivir	NNP
cord-332109-ont0tqpn	504	2	for	for	IN
cord-332109-ont0tqpn	504	3	the	the	DT
cord-332109-ont0tqpn	504	4	Treatment	Treatment	NNP
cord-332109-ont0tqpn	504	5	of	of	IN
cord-332109-ont0tqpn	504	6	Covid-19-Preliminary	covid-19-preliminary	$
cord-332109-ont0tqpn	504	7	Report	report	VB
cord-332109-ont0tqpn	504	8	Compassionate	compassionate	JJ
cord-332109-ont0tqpn	504	9	Use	Use	NNP
cord-332109-ont0tqpn	504	10	of	of	IN
cord-332109-ont0tqpn	504	11	Remdesivir	Remdesivir	NNP
cord-332109-ont0tqpn	504	12	for	for	IN
cord-332109-ont0tqpn	504	13	Patients	patient	NNS
cord-332109-ont0tqpn	504	14	with	with	IN
cord-332109-ont0tqpn	504	15	Severe	Severe	NNP
cord-332109-ont0tqpn	504	16	Covid-19	Covid-19	NNP
cord-332109-ont0tqpn	504	17	Remdesivir	Remdesivir	NNP
cord-332109-ont0tqpn	504	18	in	in	IN
cord-332109-ont0tqpn	504	19	adults	adult	NNS
cord-332109-ont0tqpn	504	20	with	with	IN
cord-332109-ont0tqpn	504	21	severe	severe	JJ
cord-332109-ont0tqpn	504	22	COVID-19	covid-19	NN
cord-332109-ont0tqpn	504	23	:	:	:
cord-332109-ont0tqpn	505	1	A	a	DT
cord-332109-ont0tqpn	505	2	randomised	randomised	JJ
cord-332109-ont0tqpn	505	3	,	,	,
cord-332109-ont0tqpn	505	4	double	double	JJ
cord-332109-ont0tqpn	505	5	-	-	HYPH
cord-332109-ont0tqpn	505	6	blind	blind	JJ
cord-332109-ont0tqpn	505	7	,	,	,
cord-332109-ont0tqpn	505	8	placebo	placebo	NN
cord-332109-ont0tqpn	505	9	-	-	HYPH
cord-332109-ont0tqpn	505	10	controlled	control	VBN
cord-332109-ont0tqpn	505	11	,	,	,
cord-332109-ont0tqpn	505	12	multicentre	multicentre	NNP
cord-332109-ont0tqpn	505	13	trial	trial	NN
cord-332109-ont0tqpn	505	14	Coronavirus	Coronavirus	NNP
cord-332109-ont0tqpn	505	15	breakthrough	breakthrough	NN
cord-332109-ont0tqpn	506	1	:	:	:
cord-332109-ont0tqpn	506	2	Dexamethasone	dexamethasone	NN
cord-332109-ont0tqpn	506	3	is	be	VBZ
cord-332109-ont0tqpn	506	4	first	first	JJ
cord-332109-ont0tqpn	506	5	drug	drug	NN
cord-332109-ont0tqpn	506	6	shown	show	VBN
cord-332109-ont0tqpn	506	7	to	to	TO
cord-332109-ont0tqpn	506	8	save	save	VB
cord-332109-ont0tqpn	506	9	lives	life	NNS
cord-332109-ont0tqpn	506	10	Structure	Structure	NNP
cord-332109-ont0tqpn	506	11	of	of	IN
cord-332109-ont0tqpn	506	12	the	the	DT
cord-332109-ont0tqpn	506	13	RNA	RNA	NNP
cord-332109-ont0tqpn	506	14	-	-	HYPH
cord-332109-ont0tqpn	506	15	dependent	dependent	JJ
cord-332109-ont0tqpn	506	16	RNA	RNA	NNP
cord-332109-ont0tqpn	506	17	polymerase	polymerase	NN
cord-332109-ont0tqpn	506	18	from	from	IN
cord-332109-ont0tqpn	506	19	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	506	20	virus	virus	NN
cord-332109-ont0tqpn	507	1	The	the	DT
cord-332109-ont0tqpn	507	2	antiviral	antiviral	JJ
cord-332109-ont0tqpn	507	3	compound	compound	NN
cord-332109-ont0tqpn	507	4	remdesivir	remdesivir	NNS
cord-332109-ont0tqpn	507	5	potently	potently	RB
cord-332109-ont0tqpn	507	6	inhibits	inhibit	VBZ
cord-332109-ont0tqpn	507	7	RNA	RNA	NNP
cord-332109-ont0tqpn	507	8	-	-	HYPH
cord-332109-ont0tqpn	507	9	dependent	dependent	JJ
cord-332109-ont0tqpn	507	10	RNA	RNA	NNP
cord-332109-ont0tqpn	507	11	polymerase	polymerase	NN
cord-332109-ont0tqpn	507	12	from	from	IN
cord-332109-ont0tqpn	507	13	Middle	Middle	NNP
cord-332109-ont0tqpn	507	14	East	East	NNP
cord-332109-ont0tqpn	507	15	respiratory	respiratory	JJ
cord-332109-ont0tqpn	507	16	syndrome	syndrome	NN
cord-332109-ont0tqpn	507	17	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	507	18	Structural	structural	JJ
cord-332109-ont0tqpn	507	19	basis	basis	NN
cord-332109-ont0tqpn	507	20	for	for	IN
cord-332109-ont0tqpn	507	21	inhibition	inhibition	NN
cord-332109-ont0tqpn	507	22	of	of	IN
cord-332109-ont0tqpn	507	23	the	the	DT
cord-332109-ont0tqpn	507	24	RNA	RNA	NNP
cord-332109-ont0tqpn	507	25	-	-	HYPH
cord-332109-ont0tqpn	507	26	dependent	dependent	JJ
cord-332109-ont0tqpn	507	27	RNA	RNA	NNP
cord-332109-ont0tqpn	507	28	polymerase	polymerase	NN
cord-332109-ont0tqpn	507	29	from	from	IN
cord-332109-ont0tqpn	507	30	SARS	SARS	NNP
cord-332109-ont0tqpn	507	31	-	-	HYPH
cord-332109-ont0tqpn	507	32	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	507	33	by	by	IN
cord-332109-ont0tqpn	507	34	remdesivir	remdesivir	NNP
cord-332109-ont0tqpn	507	35	Structure	Structure	NNP
cord-332109-ont0tqpn	507	36	of	of	IN
cord-332109-ont0tqpn	507	37	M(pro	M(pro	NNP
cord-332109-ont0tqpn	507	38	)	)	-RRB-
cord-332109-ont0tqpn	507	39	from	from	IN
cord-332109-ont0tqpn	507	40	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	507	41	virus	virus	NN
cord-332109-ont0tqpn	507	42	and	and	CC
cord-332109-ont0tqpn	507	43	discovery	discovery	NN
cord-332109-ont0tqpn	507	44	of	of	IN
cord-332109-ont0tqpn	507	45	its	-PRON-	PRP$
cord-332109-ont0tqpn	507	46	inhibitors	inhibitor	NNS
cord-332109-ont0tqpn	507	47	Crystal	Crystal	NNP
cord-332109-ont0tqpn	507	48	structure	structure	NN
cord-332109-ont0tqpn	507	49	of	of	IN
cord-332109-ont0tqpn	507	50	SARS	SARS	NNP
cord-332109-ont0tqpn	507	51	-	-	HYPH
cord-332109-ont0tqpn	507	52	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	507	53	main	main	JJ
cord-332109-ont0tqpn	507	54	protease	protease	NN
cord-332109-ont0tqpn	507	55	provides	provide	VBZ
cord-332109-ont0tqpn	507	56	a	a	DT
cord-332109-ont0tqpn	507	57	basis	basis	NN
cord-332109-ont0tqpn	507	58	for	for	IN
cord-332109-ont0tqpn	507	59	design	design	NN
cord-332109-ont0tqpn	507	60	of	of	IN
cord-332109-ont0tqpn	507	61	improved	improved	JJ
cord-332109-ont0tqpn	507	62	alpha	alpha	NN
cord-332109-ont0tqpn	507	63	-	-	HYPH
cord-332109-ont0tqpn	507	64	ketoamide	ketoamide	NN
cord-332109-ont0tqpn	507	65	inhibitors	inhibitor	NNS
cord-332109-ont0tqpn	507	66	Structural	structural	JJ
cord-332109-ont0tqpn	507	67	basis	basis	NN
cord-332109-ont0tqpn	507	68	of	of	IN
cord-332109-ont0tqpn	507	69	SARS	SARS	NNP
cord-332109-ont0tqpn	507	70	-	-	HYPH
cord-332109-ont0tqpn	507	71	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	507	72	3CLpro	3clpro	CD
cord-332109-ont0tqpn	507	73	and	and	CC
cord-332109-ont0tqpn	507	74	anti	anti	JJ
cord-332109-ont0tqpn	507	75	-	-	JJ
cord-332109-ont0tqpn	507	76	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	507	77	drug	drug	NN
cord-332109-ont0tqpn	507	78	discovery	discovery	NN
cord-332109-ont0tqpn	507	79	from	from	IN
cord-332109-ont0tqpn	507	80	medicinal	medicinal	JJ
cord-332109-ont0tqpn	507	81	plants	plant	NNS
cord-332109-ont0tqpn	507	82	Putative	Putative	NNP
cord-332109-ont0tqpn	507	83	Inhibitors	Inhibitors	NNPS
cord-332109-ont0tqpn	507	84	of	of	IN
cord-332109-ont0tqpn	507	85	SARS	SARS	NNP
cord-332109-ont0tqpn	507	86	-	-	HYPH
cord-332109-ont0tqpn	507	87	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	507	88	Main	Main	NNP
cord-332109-ont0tqpn	507	89	Protease	Protease	NNP
cord-332109-ont0tqpn	507	90	from	from	IN
cord-332109-ont0tqpn	507	91	A	a	DT
cord-332109-ont0tqpn	507	92	Library	Library	NNP
cord-332109-ont0tqpn	507	93	of	of	IN
cord-332109-ont0tqpn	507	94	Marine	Marine	NNP
cord-332109-ont0tqpn	507	95	Natural	Natural	NNP
cord-332109-ont0tqpn	507	96	Products	Products	NNPS
cord-332109-ont0tqpn	507	97	:	:	:
cord-332109-ont0tqpn	508	1	A	a	DT
cord-332109-ont0tqpn	508	2	Virtual	virtual	JJ
cord-332109-ont0tqpn	508	3	Screening	screening	NN
cord-332109-ont0tqpn	508	4	and	and	CC
cord-332109-ont0tqpn	508	5	Molecular	Molecular	NNP
cord-332109-ont0tqpn	508	6	Modeling	Modeling	NNP
cord-332109-ont0tqpn	508	7	Study	Study	NNP
cord-332109-ont0tqpn	508	8	Structure	Structure	NNP
cord-332109-ont0tqpn	508	9	-	-	HYPH
cord-332109-ont0tqpn	508	10	based	base	VBN
cord-332109-ont0tqpn	508	11	design	design	NN
cord-332109-ont0tqpn	508	12	of	of	IN
cord-332109-ont0tqpn	508	13	antiviral	antiviral	JJ
cord-332109-ont0tqpn	508	14	drug	drug	NN
cord-332109-ont0tqpn	508	15	candidates	candidate	NNS
cord-332109-ont0tqpn	508	16	targeting	target	VBG
cord-332109-ont0tqpn	508	17	the	the	DT
cord-332109-ont0tqpn	508	18	SARS	SARS	NNP
cord-332109-ont0tqpn	508	19	-	-	HYPH
cord-332109-ont0tqpn	508	20	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	508	21	main	main	JJ
cord-332109-ont0tqpn	508	22	protease	protease	NN
cord-332109-ont0tqpn	508	23	A	a	DT
cord-332109-ont0tqpn	508	24	non	non	JJ
cord-332109-ont0tqpn	508	25	-	-	JJ
cord-332109-ont0tqpn	508	26	competing	competing	JJ
cord-332109-ont0tqpn	508	27	pair	pair	NN
cord-332109-ont0tqpn	508	28	of	of	IN
cord-332109-ont0tqpn	508	29	human	human	JJ
cord-332109-ont0tqpn	508	30	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	508	31	antibodies	antibody	NNS
cord-332109-ont0tqpn	508	32	block	block	VBP
cord-332109-ont0tqpn	508	33	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	508	34	virus	virus	NN
cord-332109-ont0tqpn	508	35	binding	bind	VBG
cord-332109-ont0tqpn	508	36	to	to	IN
cord-332109-ont0tqpn	509	1	its	-PRON-	PRP$
cord-332109-ont0tqpn	509	2	receptor	receptor	NN
cord-332109-ont0tqpn	509	3	ACE2	ACE2	NNP
cord-332109-ont0tqpn	509	4	A	a	DT
cord-332109-ont0tqpn	509	5	human	human	JJ
cord-332109-ont0tqpn	509	6	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	509	7	antibody	antibody	NN
cord-332109-ont0tqpn	509	8	targets	target	VBZ
cord-332109-ont0tqpn	509	9	the	the	DT
cord-332109-ont0tqpn	509	10	receptor	receptor	NN
cord-332109-ont0tqpn	509	11	binding	bind	VBG
cord-332109-ont0tqpn	509	12	site	site	NN
cord-332109-ont0tqpn	509	13	of	of	IN
cord-332109-ont0tqpn	509	14	SARS	SARS	NNP
cord-332109-ont0tqpn	509	15	-	-	HYPH
cord-332109-ont0tqpn	509	16	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	509	17	Isolation	isolation	NN
cord-332109-ont0tqpn	509	18	of	of	IN
cord-332109-ont0tqpn	509	19	potent	potent	JJ
cord-332109-ont0tqpn	509	20	SARS	SARS	NNP
cord-332109-ont0tqpn	509	21	-	-	HYPH
cord-332109-ont0tqpn	509	22	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	509	23	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	509	24	antibodies	antibody	NNS
cord-332109-ont0tqpn	509	25	and	and	CC
cord-332109-ont0tqpn	509	26	protection	protection	NN
cord-332109-ont0tqpn	509	27	from	from	IN
cord-332109-ont0tqpn	509	28	disease	disease	NN
cord-332109-ont0tqpn	509	29	in	in	IN
cord-332109-ont0tqpn	509	30	a	a	DT
cord-332109-ont0tqpn	509	31	small	small	JJ
cord-332109-ont0tqpn	509	32	animal	animal	NN
cord-332109-ont0tqpn	509	33	model	model	NN
cord-332109-ont0tqpn	509	34	Human	human	JJ
cord-332109-ont0tqpn	509	35	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	509	36	antibodies	antibody	NNS
cord-332109-ont0tqpn	509	37	elicited	elicit	VBN
cord-332109-ont0tqpn	509	38	by	by	IN
cord-332109-ont0tqpn	509	39	SARS	SARS	NNP
cord-332109-ont0tqpn	509	40	-	-	HYPH
cord-332109-ont0tqpn	509	41	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	509	42	infection	infection	NN
cord-332109-ont0tqpn	510	1	Broad	broad	JJ
cord-332109-ont0tqpn	510	2	neutralization	neutralization	NN
cord-332109-ont0tqpn	510	3	of	of	IN
cord-332109-ont0tqpn	510	4	SARS	SARS	NNP
cord-332109-ont0tqpn	510	5	-	-	HYPH
cord-332109-ont0tqpn	510	6	related	relate	VBN
cord-332109-ont0tqpn	510	7	viruses	virus	NNS
cord-332109-ont0tqpn	510	8	by	by	IN
cord-332109-ont0tqpn	510	9	human	human	JJ
cord-332109-ont0tqpn	510	10	monoclonal	monoclonal	JJ
cord-332109-ont0tqpn	510	11	antibodies	antibody	NNS
cord-332109-ont0tqpn	510	12	Neutralization	Neutralization	NNP
cord-332109-ont0tqpn	510	13	of	of	IN
cord-332109-ont0tqpn	510	14	SARS	SARS	NNP
cord-332109-ont0tqpn	510	15	-	-	HYPH
cord-332109-ont0tqpn	510	16	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	510	17	spike	spike	NN
cord-332109-ont0tqpn	510	18	pseudotyped	pseudotype	VBD
cord-332109-ont0tqpn	510	19	virus	virus	NN
cord-332109-ont0tqpn	510	20	by	by	IN
cord-332109-ont0tqpn	510	21	recombinant	recombinant	JJ
cord-332109-ont0tqpn	510	22	ACE2-Ig	ACE2-Ig	NNP
cord-332109-ont0tqpn	510	23	Structural	Structural	NNP
cord-332109-ont0tqpn	510	24	Basis	Basis	NNP
cord-332109-ont0tqpn	510	25	for	for	IN
cord-332109-ont0tqpn	510	26	Potent	potent	JJ
cord-332109-ont0tqpn	510	27	Neutralization	neutralization	NN
cord-332109-ont0tqpn	510	28	of	of	IN
cord-332109-ont0tqpn	510	29	Betacoronaviruses	Betacoronaviruses	NNP
cord-332109-ont0tqpn	510	30	by	by	IN
cord-332109-ont0tqpn	510	31	Single	Single	NNP
cord-332109-ont0tqpn	510	32	-	-	HYPH
cord-332109-ont0tqpn	510	33	Domain	Domain	NNP
cord-332109-ont0tqpn	510	34	Camelid	Camelid	NNP
cord-332109-ont0tqpn	510	35	Antibodies	Antibodies	NNP
cord-332109-ont0tqpn	510	36	Studies	Studies	NNPS
cord-332109-ont0tqpn	510	37	in	in	IN
cord-332109-ont0tqpn	510	38	humanized	humanized	JJ
cord-332109-ont0tqpn	510	39	mice	mouse	NNS
cord-332109-ont0tqpn	510	40	and	and	CC
cord-332109-ont0tqpn	511	1	convalescent	convalescent	JJ
cord-332109-ont0tqpn	511	2	humans	human	NNS
cord-332109-ont0tqpn	511	3	yield	yield	VBP
cord-332109-ont0tqpn	511	4	a	a	DT
cord-332109-ont0tqpn	511	5	SARS	SARS	NNP
cord-332109-ont0tqpn	511	6	-	-	HYPH
cord-332109-ont0tqpn	511	7	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	511	8	antibody	antibody	NN
cord-332109-ont0tqpn	511	9	cocktail	cocktail	NN
cord-332109-ont0tqpn	511	10	Potent	potent	JJ
cord-332109-ont0tqpn	511	11	neutralizing	neutralize	VBG
cord-332109-ont0tqpn	511	12	antibodies	antibody	NNS
cord-332109-ont0tqpn	511	13	from	from	IN
cord-332109-ont0tqpn	511	14	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	511	15	patients	patient	NNS
cord-332109-ont0tqpn	511	16	define	define	VBP
cord-332109-ont0tqpn	511	17	multiple	multiple	JJ
cord-332109-ont0tqpn	511	18	targets	target	NNS
cord-332109-ont0tqpn	511	19	of	of	IN
cord-332109-ont0tqpn	511	20	vulnerability	vulnerability	NN
cord-332109-ont0tqpn	511	21	Antibody	Antibody	NNP
cord-332109-ont0tqpn	511	22	cocktail	cocktail	NN
cord-332109-ont0tqpn	511	23	to	to	IN
cord-332109-ont0tqpn	511	24	SARS	SARS	NNP
cord-332109-ont0tqpn	511	25	-	-	HYPH
cord-332109-ont0tqpn	511	26	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	511	27	spike	spike	NN
cord-332109-ont0tqpn	511	28	protein	protein	NN
cord-332109-ont0tqpn	512	1	prevents	prevent	VBZ
cord-332109-ont0tqpn	512	2	rapid	rapid	JJ
cord-332109-ont0tqpn	512	3	mutational	mutational	JJ
cord-332109-ont0tqpn	512	4	escape	escape	NN
cord-332109-ont0tqpn	512	5	seen	see	VBN
cord-332109-ont0tqpn	512	6	with	with	IN
cord-332109-ont0tqpn	512	7	individual	individual	JJ
cord-332109-ont0tqpn	512	8	antibodies	antibody	NNS
cord-332109-ont0tqpn	513	1	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	513	2	vaccine	vaccine	NN
cord-332109-ont0tqpn	513	3	design	design	NN
cord-332109-ont0tqpn	513	4	:	:	:
cord-332109-ont0tqpn	514	1	The	the	DT
cord-332109-ont0tqpn	514	2	Janus	Janus	NNP
cord-332109-ont0tqpn	514	3	face	face	NN
cord-332109-ont0tqpn	514	4	of	of	IN
cord-332109-ont0tqpn	514	5	immune	immune	JJ
cord-332109-ont0tqpn	514	6	enhancement	enhancement	NN
cord-332109-ont0tqpn	514	7	Draft	Draft	NNP
cord-332109-ont0tqpn	514	8	Landscape	Landscape	NNP
cord-332109-ont0tqpn	514	9	of	of	IN
cord-332109-ont0tqpn	514	10	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	514	11	Candidate	Candidate	NNP
cord-332109-ont0tqpn	515	1	Vaccines	vaccine	NNS
cord-332109-ont0tqpn	515	2	The	the	DT
cord-332109-ont0tqpn	515	3	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	515	4	vaccine	vaccine	NN
cord-332109-ont0tqpn	515	5	development	development	NN
cord-332109-ont0tqpn	515	6	landscape	landscape	NN
cord-332109-ont0tqpn	516	1	An	an	DT
cord-332109-ont0tqpn	516	2	Evidence	evidence	NN
cord-332109-ont0tqpn	516	3	Based	Based	NNP
cord-332109-ont0tqpn	516	4	Perspective	Perspective	NNP
cord-332109-ont0tqpn	516	5	on	on	IN
cord-332109-ont0tqpn	517	1	mRNA	mRNA	NNP
cord-332109-ont0tqpn	517	2	-	-	HYPH
cord-332109-ont0tqpn	517	3	SARS	SARS	NNP
cord-332109-ont0tqpn	517	4	-	-	HYPH
cord-332109-ont0tqpn	517	5	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	517	6	Vaccine	Vaccine	NNP
cord-332109-ont0tqpn	517	7	Development	Development	NNP
cord-332109-ont0tqpn	517	8	An	an	DT
cord-332109-ont0tqpn	517	9	mRNA	mrna	NN
cord-332109-ont0tqpn	517	10	Vaccine	Vaccine	NNP
cord-332109-ont0tqpn	517	11	against	against	IN
cord-332109-ont0tqpn	517	12	SARS	SARS	NNP
cord-332109-ont0tqpn	517	13	-	-	HYPH
cord-332109-ont0tqpn	517	14	CoV-2-Preliminary	CoV-2-Preliminary	NNP
cord-332109-ont0tqpn	517	15	Report	Report	NNP
cord-332109-ont0tqpn	517	16	Safety	Safety	NNP
cord-332109-ont0tqpn	517	17	,	,	,
cord-332109-ont0tqpn	517	18	tolerability	tolerability	NN
cord-332109-ont0tqpn	517	19	,	,	,
cord-332109-ont0tqpn	517	20	and	and	CC
cord-332109-ont0tqpn	517	21	immunogenicity	immunogenicity	NN
cord-332109-ont0tqpn	517	22	of	of	IN
cord-332109-ont0tqpn	517	23	a	a	DT
cord-332109-ont0tqpn	517	24	recombinant	recombinant	JJ
cord-332109-ont0tqpn	517	25	adenovirus	adenovirus	NN
cord-332109-ont0tqpn	517	26	type-5	type-5	IN
cord-332109-ont0tqpn	517	27	vectored	vectore	VBN
cord-332109-ont0tqpn	517	28	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	517	29	vaccine	vaccine	NN
cord-332109-ont0tqpn	517	30	:	:	:
cord-332109-ont0tqpn	518	1	A	a	DT
cord-332109-ont0tqpn	518	2	dose	dose	NN
cord-332109-ont0tqpn	518	3	-	-	HYPH
cord-332109-ont0tqpn	518	4	escalation	escalation	NN
cord-332109-ont0tqpn	518	5	,	,	,
cord-332109-ont0tqpn	518	6	open	open	JJ
cord-332109-ont0tqpn	518	7	-	-	HYPH
cord-332109-ont0tqpn	518	8	label	label	NN
cord-332109-ont0tqpn	518	9	,	,	,
cord-332109-ont0tqpn	518	10	non	non	JJ
cord-332109-ont0tqpn	518	11	-	-	JJ
cord-332109-ont0tqpn	518	12	randomised	randomised	JJ
cord-332109-ont0tqpn	518	13	Trials	trial	NNS
cord-332109-ont0tqpn	518	14	of	of	IN
cord-332109-ont0tqpn	518	15	anti	anti	JJ
cord-332109-ont0tqpn	518	16	-	-	JJ
cord-332109-ont0tqpn	518	17	tumour	tumour	JJ
cord-332109-ont0tqpn	518	18	necrosis	necrosis	NN
cord-332109-ont0tqpn	518	19	factor	factor	NN
cord-332109-ont0tqpn	518	20	therapy	therapy	NN
cord-332109-ont0tqpn	518	21	for	for	IN
cord-332109-ont0tqpn	518	22	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	518	23	are	be	VBP
cord-332109-ont0tqpn	518	24	urgently	urgently	RB
cord-332109-ont0tqpn	518	25	needed	need	VBN
cord-332109-ont0tqpn	518	26	Induction	Induction	NNP
cord-332109-ont0tqpn	518	27	of	of	IN
cord-332109-ont0tqpn	518	28	pro	pro	JJ
cord-332109-ont0tqpn	518	29	-	-	JJ
cord-332109-ont0tqpn	518	30	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	518	31	cytokines	cytokine	NNS
cord-332109-ont0tqpn	518	32	(	(	-LRB-
cord-332109-ont0tqpn	518	33	IL-1	IL-1	NNP
cord-332109-ont0tqpn	518	34	and	and	CC
cord-332109-ont0tqpn	518	35	IL-6	IL-6	NNP
cord-332109-ont0tqpn	518	36	)	)	-RRB-
cord-332109-ont0tqpn	518	37	and	and	CC
cord-332109-ont0tqpn	518	38	lung	lung	NN
cord-332109-ont0tqpn	518	39	inflammation	inflammation	NN
cord-332109-ont0tqpn	518	40	by	by	IN
cord-332109-ont0tqpn	518	41	Coronavirus-19	Coronavirus-19	NNP
cord-332109-ont0tqpn	518	42	(	(	-LRB-
cord-332109-ont0tqpn	518	43	COVI-19	COVI-19	NNP
cord-332109-ont0tqpn	518	44	or	or	CC
cord-332109-ont0tqpn	518	45	SARS	SARS	NNP
cord-332109-ont0tqpn	518	46	-	-	HYPH
cord-332109-ont0tqpn	518	47	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	518	48	)	)	-RRB-
cord-332109-ont0tqpn	518	49	:	:	:
cord-332109-ont0tqpn	518	50	Anti	anti	JJ
cord-332109-ont0tqpn	518	51	-	-	JJ
cord-332109-ont0tqpn	518	52	inflammatory	inflammatory	JJ
cord-332109-ont0tqpn	518	53	strategies	strategy	NNS
cord-332109-ont0tqpn	518	54	Breadth	Breadth	NNP
cord-332109-ont0tqpn	518	55	of	of	IN
cord-332109-ont0tqpn	518	56	concomitant	concomitant	JJ
cord-332109-ont0tqpn	518	57	immune	immune	JJ
cord-332109-ont0tqpn	518	58	responses	response	NNS
cord-332109-ont0tqpn	518	59	prior	prior	RB
cord-332109-ont0tqpn	518	60	to	to	IN
cord-332109-ont0tqpn	518	61	patient	patient	NN
cord-332109-ont0tqpn	518	62	recovery	recovery	NN
cord-332109-ont0tqpn	518	63	:	:	:
cord-332109-ont0tqpn	519	1	A	a	DT
cord-332109-ont0tqpn	519	2	case	case	NN
cord-332109-ont0tqpn	519	3	report	report	NN
cord-332109-ont0tqpn	519	4	of	of	IN
cord-332109-ont0tqpn	519	5	non	non	JJ
cord-332109-ont0tqpn	519	6	-	-	JJ
cord-332109-ont0tqpn	519	7	severe	severe	JJ
cord-332109-ont0tqpn	519	8	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	519	9	Targets	Targets	NNPS
cord-332109-ont0tqpn	519	10	of	of	IN
cord-332109-ont0tqpn	519	11	T	T	NNP
cord-332109-ont0tqpn	519	12	cell	cell	NN
cord-332109-ont0tqpn	519	13	responses	response	NNS
cord-332109-ont0tqpn	519	14	to	to	IN
cord-332109-ont0tqpn	519	15	SARS	SARS	NNP
cord-332109-ont0tqpn	519	16	-	-	HYPH
cord-332109-ont0tqpn	519	17	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	519	18	coronavirus	coronavirus	NN
cord-332109-ont0tqpn	519	19	in	in	IN
cord-332109-ont0tqpn	519	20	humans	human	NNS
cord-332109-ont0tqpn	519	21	with	with	IN
cord-332109-ont0tqpn	519	22	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	519	23	disease	disease	NN
cord-332109-ont0tqpn	519	24	and	and	CC
cord-332109-ont0tqpn	519	25	unexposed	unexposed	JJ
cord-332109-ont0tqpn	519	26	individuals	individual	NNS
cord-332109-ont0tqpn	519	27	Presence	Presence	NNP
cord-332109-ont0tqpn	519	28	of	of	IN
cord-332109-ont0tqpn	519	29	SARS	SARS	NNP
cord-332109-ont0tqpn	519	30	-	-	HYPH
cord-332109-ont0tqpn	519	31	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	519	32	reactive	reactive	JJ
cord-332109-ont0tqpn	519	33	T	t	NN
cord-332109-ont0tqpn	519	34	cells	cell	NNS
cord-332109-ont0tqpn	519	35	in	in	IN
cord-332109-ont0tqpn	519	36	COVID-19	covid-19	JJ
cord-332109-ont0tqpn	519	37	patients	patient	NNS
cord-332109-ont0tqpn	519	38	and	and	CC
cord-332109-ont0tqpn	519	39	healthy	healthy	JJ
cord-332109-ont0tqpn	519	40	donors	donor	NNS
cord-332109-ont0tqpn	519	41	Clinical	clinical	JJ
cord-332109-ont0tqpn	519	42	and	and	CC
cord-332109-ont0tqpn	519	43	immunological	immunological	JJ
cord-332109-ont0tqpn	519	44	assessment	assessment	NN
cord-332109-ont0tqpn	519	45	of	of	IN
cord-332109-ont0tqpn	519	46	asymptomatic	asymptomatic	JJ
cord-332109-ont0tqpn	519	47	SARS	SARS	NNP
cord-332109-ont0tqpn	519	48	-	-	HYPH
cord-332109-ont0tqpn	519	49	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	519	50	infections	infection	NNS
cord-332109-ont0tqpn	520	1	The	the	DT
cord-332109-ont0tqpn	520	2	potential	potential	JJ
cord-332109-ont0tqpn	520	3	danger	danger	NN
cord-332109-ont0tqpn	520	4	of	of	IN
cord-332109-ont0tqpn	520	5	suboptimal	suboptimal	JJ
cord-332109-ont0tqpn	520	6	antibody	antibody	NN
cord-332109-ont0tqpn	520	7	responses	response	NNS
cord-332109-ont0tqpn	520	8	in	in	IN
cord-332109-ont0tqpn	520	9	COVID-19	COVID-19	NNP
cord-332109-ont0tqpn	520	10	Antibody	Antibody	NNP
cord-332109-ont0tqpn	520	11	-	-	HYPH
cord-332109-ont0tqpn	520	12	Dependent	Dependent	NNP
cord-332109-ont0tqpn	520	13	Enhancement	enhancement	NN
cord-332109-ont0tqpn	520	14	of	of	IN
cord-332109-ont0tqpn	520	15	Viral	Viral	NNP
cord-332109-ont0tqpn	520	16	Infections	Infections	NNPS
cord-332109-ont0tqpn	520	17	Opioid	opioid	JJ
cord-332109-ont0tqpn	520	18	use	use	NN
cord-332109-ont0tqpn	520	19	disorder	disorder	NN
cord-332109-ont0tqpn	520	20	and	and	CC
cord-332109-ont0tqpn	520	21	the	the	DT
cord-332109-ont0tqpn	520	22	COVID	covid	JJ
cord-332109-ont0tqpn	520	23	19	19	CD
cord-332109-ont0tqpn	520	24	pandemic	pandemic	NN
cord-332109-ont0tqpn	520	25	:	:	:
cord-332109-ont0tqpn	520	26	A	a	DT
cord-332109-ont0tqpn	520	27	call	call	NN
cord-332109-ont0tqpn	520	28	to	to	TO
cord-332109-ont0tqpn	520	29	sustain	sustain	VB
cord-332109-ont0tqpn	520	30	regulatory	regulatory	JJ
cord-332109-ont0tqpn	520	31	easements	easement	NNS
cord-332109-ont0tqpn	520	32	and	and	CC
cord-332109-ont0tqpn	520	33	further	further	RB
cord-332109-ont0tqpn	520	34	expand	expand	VB
cord-332109-ont0tqpn	520	35	access	access	NN
cord-332109-ont0tqpn	520	36	to	to	IN
cord-332109-ont0tqpn	520	37	treatment	treatment	NN
cord-332109-ont0tqpn	520	38	Projecting	project	VBG
cord-332109-ont0tqpn	520	39	the	the	DT
cord-332109-ont0tqpn	520	40	transmission	transmission	NN
cord-332109-ont0tqpn	520	41	dynamics	dynamic	NNS
cord-332109-ont0tqpn	520	42	of	of	IN
cord-332109-ont0tqpn	520	43	SARS	SARS	NNP
cord-332109-ont0tqpn	520	44	-	-	:
cord-332109-ont0tqpn	520	45	CoV-2	CoV-2	NNP
cord-332109-ont0tqpn	520	46	through	through	IN
cord-332109-ont0tqpn	520	47	the	the	DT
cord-332109-ont0tqpn	520	48	postpandemic	postpandemic	JJ
cord-332109-ont0tqpn	520	49	period	period	NN
cord-332109-ont0tqpn	521	1	This	this	DT
cord-332109-ont0tqpn	521	2	article	article	NN
cord-332109-ont0tqpn	521	3	is	be	VBZ
cord-332109-ont0tqpn	521	4	an	an	DT
cord-332109-ont0tqpn	521	5	open	open	JJ
cord-332109-ont0tqpn	521	6	access	access	NN
cord-332109-ont0tqpn	521	7	article	article	NN
cord-332109-ont0tqpn	521	8	distributed	distribute	VBN
cord-332109-ont0tqpn	521	9	under	under	IN
cord-332109-ont0tqpn	521	10	the	the	DT
cord-332109-ont0tqpn	521	11	terms	term	NNS
cord-332109-ont0tqpn	521	12	and	and	CC
cord-332109-ont0tqpn	521	13	conditions	condition	NNS
cord-332109-ont0tqpn	521	14	of	of	IN
cord-332109-ont0tqpn	521	15	the	the	DT
cord-332109-ont0tqpn	521	16	Creative	Creative	NNP
cord-332109-ont0tqpn	521	17	Commons	Commons	NNP
cord-332109-ont0tqpn	521	18	Attribution	Attribution	NNP
cord-332109-ont0tqpn	522	1	We	-PRON-	PRP
cord-332109-ont0tqpn	522	2	thank	thank	VBP
cord-332109-ont0tqpn	522	3	Ammer	Ammer	NNP
cord-332109-ont0tqpn	522	4	Abdin	Abdin	NNP
cord-332109-ont0tqpn	522	5	,	,	,
cord-332109-ont0tqpn	522	6	Madellyne	Madellyne	NNP
cord-332109-ont0tqpn	522	7	Sanchez	Sanchez	NNP
cord-332109-ont0tqpn	522	8	,	,	,
cord-332109-ont0tqpn	522	9	and	and	CC
cord-332109-ont0tqpn	522	10	Song	Song	NNP
cord-332109-ont0tqpn	522	11	Zhang	Zhang	NNP
cord-332109-ont0tqpn	522	12	,	,	,
cord-332109-ont0tqpn	522	13	for	for	IN
cord-332109-ont0tqpn	522	14	collecting	collect	VBG
cord-332109-ont0tqpn	522	15	and	and	CC
cord-332109-ont0tqpn	522	16	analyzing	analyze	VBG
cord-332109-ont0tqpn	522	17	relevant	relevant	JJ
cord-332109-ont0tqpn	522	18	literatures	literature	NNS
cord-332109-ont0tqpn	522	19	and	and	CC
cord-332109-ont0tqpn	522	20	intellectual	intellectual	JJ
cord-332109-ont0tqpn	522	21	discussions	discussion	NNS
cord-332109-ont0tqpn	522	22	for	for	IN
cord-332109-ont0tqpn	522	23	this	this	DT
cord-332109-ont0tqpn	522	24	article	article	NN
cord-332109-ont0tqpn	522	25	.	.	.
cord-332109-ont0tqpn	523	1	The	the	DT
cord-332109-ont0tqpn	523	2	authors	author	NNS
cord-332109-ont0tqpn	523	3	declare	declare	VBP
cord-332109-ont0tqpn	523	4	no	no	DT
cord-332109-ont0tqpn	523	5	conflict	conflict	NN
cord-332109-ont0tqpn	523	6	of	of	IN
cord-332109-ont0tqpn	523	7	interest	interest	NN
cord-332109-ont0tqpn	523	8	.	.	.