id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336759-cu1uprwm	Cihan-Üstündağ, Gökçe	Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives	2019-07-17		.txt	text/plain	2993	183	55	Compounds bearing a phenyl substituent at position 8 of the spiro ring, exhibited significant antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at concentrations of 3.9 and 7.8 µM. Based on these insights and our objective to optimize the antimicrobial activity of indolyl thiazolidinones and spirothiazolidinones, we here report the chemical synthesis, structural characterization and in vitro antitubercular, antiviral, antibacterial, and antifungal evaluation of new 5-chloro-3-phenyl-N(2,7,8,9substituted/nonsubstituted-3-oxo-1-thia-4-azaspiro [4.4] nonan/ [4.5] decan-4-yl)-1H-indole-2-carboxamides 4a-4i, 5a-5h (Fig. 1e ). As shown in Table 1 , compounds 4 h and 5h, bearing a phenyl substituent at position 8 of the spiro ring, exhibited the highest anti-TB activity at concentrations of 3.9 and 7.8 µM, respectively. The broad antibacterial and antifungal activity of compounds 4a-4i and 5a-5 h was further assessed using The experiment was performed twice and the same results were obtained a MIC, the actual minimum inhibitory concentration required to inhibit the growth of 100% of organisms 	./cache/cord-336759-cu1uprwm.txt	./txt/cord-336759-cu1uprwm.txt