id	sid	tid	token	lemma	pos
cord-033493-kslzdy8q	1	1	key	key	JJ
cord-033493-kslzdy8q	1	2	:	:	:
cord-033493-kslzdy8q	1	3	cord-033493-kslzdy8q	cord-033493-kslzdy8q	JJ
cord-033493-kslzdy8q	1	4	authors	author	NNS
cord-033493-kslzdy8q	1	5	:	:	:
cord-033493-kslzdy8q	1	6	Hebishy	Hebishy	NNP
cord-033493-kslzdy8q	1	7	,	,	,
cord-033493-kslzdy8q	1	8	Ali	Ali	NNP
cord-033493-kslzdy8q	1	9	M.	M.	NNP
cord-033493-kslzdy8q	1	10	S.	S.	NNP
cord-033493-kslzdy8q	1	11	;	;	:
cord-033493-kslzdy8q	1	12	Salama	Salama	NNP
cord-033493-kslzdy8q	1	13	,	,	,
cord-033493-kslzdy8q	1	14	Hagar	Hagar	NNP
cord-033493-kslzdy8q	1	15	T.	T.	NNP
cord-033493-kslzdy8q	1	16	;	;	:
cord-033493-kslzdy8q	1	17	Elgemeie	Elgemeie	NNP
cord-033493-kslzdy8q	1	18	,	,	,
cord-033493-kslzdy8q	1	19	Galal	Galal	NNP
cord-033493-kslzdy8q	1	20	H.	H.	NNP
cord-033493-kslzdy8q	1	21	title	title	NN
cord-033493-kslzdy8q	1	22	:	:	:
cord-033493-kslzdy8q	1	23	New	New	NNP
cord-033493-kslzdy8q	1	24	Route	Route	NNP
cord-033493-kslzdy8q	1	25	to	to	IN
cord-033493-kslzdy8q	1	26	the	the	DT
cord-033493-kslzdy8q	1	27	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	1	28	of	of	IN
cord-033493-kslzdy8q	1	29	Benzamide	Benzamide	NNP
cord-033493-kslzdy8q	1	30	-	-	HYPH
cord-033493-kslzdy8q	1	31	Based	base	VBN
cord-033493-kslzdy8q	1	32	5-Aminopyrazoles	5-aminopyrazoles	XX
cord-033493-kslzdy8q	2	1	and	and	CC
cord-033493-kslzdy8q	2	2	Their	-PRON-	PRP$
cord-033493-kslzdy8q	2	3	Fused	Fused	NNP
cord-033493-kslzdy8q	2	4	Heterocycles	Heterocycles	NNP
cord-033493-kslzdy8q	2	5	Showing	show	VBG
cord-033493-kslzdy8q	2	6	Remarkable	remarkable	JJ
cord-033493-kslzdy8q	2	7	Antiavian	Antiavian	NNP
cord-033493-kslzdy8q	2	8	Influenza	Influenza	NNP
cord-033493-kslzdy8q	2	9	Virus	Virus	NNP
cord-033493-kslzdy8q	2	10	Activity	Activity	NNP
cord-033493-kslzdy8q	2	11	date	date	NN
cord-033493-kslzdy8q	2	12	:	:	:
cord-033493-kslzdy8q	2	13	2020	2020	CD
cord-033493-kslzdy8q	2	14	-	-	HYPH
cord-033493-kslzdy8q	2	15	09	09	CD
cord-033493-kslzdy8q	2	16	-	-	SYM
cord-033493-kslzdy8q	2	17	21	21	CD
cord-033493-kslzdy8q	2	18	journal	journal	NN
cord-033493-kslzdy8q	2	19	:	:	:
cord-033493-kslzdy8q	3	1	ACS	ACS	NNP
cord-033493-kslzdy8q	3	2	Omega	omega	NN
cord-033493-kslzdy8q	3	3	DOI	DOI	NNP
cord-033493-kslzdy8q	3	4	:	:	:
cord-033493-kslzdy8q	4	1	10.1021	10.1021	CD
cord-033493-kslzdy8q	4	2	/	/	SYM
cord-033493-kslzdy8q	4	3	acsomega.0c02675	acsomega.0c02675	NNP
cord-033493-kslzdy8q	4	4	sha	sha	NNP
cord-033493-kslzdy8q	4	5	:	:	:
cord-033493-kslzdy8q	4	6	8707a6182d23f1206c48de6eb272312052944c3e	8707a6182d23f1206c48de6eb272312052944c3e	NNP
cord-033493-kslzdy8q	4	7	doc_id	doc_id	CD
cord-033493-kslzdy8q	4	8	:	:	:
cord-033493-kslzdy8q	4	9	33493	33493	CD
cord-033493-kslzdy8q	4	10	cord_uid	cord_uid	NNS
cord-033493-kslzdy8q	4	11	:	:	:
cord-033493-kslzdy8q	5	1	kslzdy8q	kslzdy8q	NNP
cord-033493-kslzdy8q	6	1	[	[	-LRB-
cord-033493-kslzdy8q	6	2	Image	image	NN
cord-033493-kslzdy8q	6	3	:	:	:
cord-033493-kslzdy8q	6	4	see	see	VB
cord-033493-kslzdy8q	6	5	text	text	NN
cord-033493-kslzdy8q	6	6	]	]	-RRB-
cord-033493-kslzdy8q	7	1	This	this	DT
cord-033493-kslzdy8q	7	2	study	study	NN
cord-033493-kslzdy8q	7	3	describes	describe	VBZ
cord-033493-kslzdy8q	7	4	a	a	DT
cord-033493-kslzdy8q	7	5	new	new	JJ
cord-033493-kslzdy8q	7	6	route	route	NN
cord-033493-kslzdy8q	7	7	to	to	IN
cord-033493-kslzdy8q	7	8	the	the	DT
cord-033493-kslzdy8q	7	9	synthesis	synthesis	NN
cord-033493-kslzdy8q	7	10	of	of	IN
cord-033493-kslzdy8q	7	11	novel	novel	JJ
cord-033493-kslzdy8q	7	12	benzamide	benzamide	NN
cord-033493-kslzdy8q	7	13	-	-	HYPH
cord-033493-kslzdy8q	7	14	based	base	VBN
cord-033493-kslzdy8q	7	15	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	7	16	and	and	CC
cord-033493-kslzdy8q	7	17	their	-PRON-	PRP$
cord-033493-kslzdy8q	7	18	corresponding	correspond	VBG
cord-033493-kslzdy8q	7	19	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	JJ
cord-033493-kslzdy8q	7	20	and	and	CC
cord-033493-kslzdy8q	7	21	pyrazolo[5,1-c][1,2,4]triazine	pyrazolo[5,1-c][1,2,4]triazine	JJ
cord-033493-kslzdy8q	7	22	derivatives	derivative	NNS
cord-033493-kslzdy8q	7	23	.	.	.
cord-033493-kslzdy8q	8	1	Benzamide	Benzamide	NNP
cord-033493-kslzdy8q	8	2	-	-	HYPH
cord-033493-kslzdy8q	8	3	based	base	VBN
cord-033493-kslzdy8q	8	4	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	8	5	were	be	VBD
cord-033493-kslzdy8q	8	6	prepared	prepare	VBN
cord-033493-kslzdy8q	8	7	through	through	IN
cord-033493-kslzdy8q	8	8	a	a	DT
cord-033493-kslzdy8q	8	9	reaction	reaction	NN
cord-033493-kslzdy8q	8	10	of	of	IN
cord-033493-kslzdy8q	8	11	benzoyl	benzoyl	NN
cord-033493-kslzdy8q	8	12	isothiocyanate	isothiocyanate	NN
cord-033493-kslzdy8q	8	13	with	with	IN
cord-033493-kslzdy8q	8	14	malononitrile	malononitrile	NN
cord-033493-kslzdy8q	8	15	in	in	IN
cord-033493-kslzdy8q	8	16	KOH	KOH	NNP
cord-033493-kslzdy8q	8	17	–	–	:
cord-033493-kslzdy8q	8	18	EtOH	EtOH	NNP
cord-033493-kslzdy8q	8	19	followed	follow	VBD
cord-033493-kslzdy8q	8	20	by	by	IN
cord-033493-kslzdy8q	8	21	alkylation	alkylation	NN
cord-033493-kslzdy8q	8	22	with	with	IN
cord-033493-kslzdy8q	8	23	alkyl	alkyl	JJ
cord-033493-kslzdy8q	8	24	halides	halide	NNS
cord-033493-kslzdy8q	8	25	and	and	CC
cord-033493-kslzdy8q	8	26	then	then	RB
cord-033493-kslzdy8q	8	27	a	a	DT
cord-033493-kslzdy8q	8	28	reaction	reaction	NN
cord-033493-kslzdy8q	8	29	with	with	IN
cord-033493-kslzdy8q	8	30	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	8	31	.	.	.
cord-033493-kslzdy8q	9	1	In	in	IN
cord-033493-kslzdy8q	9	2	an	an	DT
cord-033493-kslzdy8q	9	3	attempt	attempt	NN
cord-033493-kslzdy8q	9	4	to	to	TO
cord-033493-kslzdy8q	9	5	react	react	VB
cord-033493-kslzdy8q	9	6	benzoyl	benzoyl	NN
cord-033493-kslzdy8q	9	7	isothiocyanate	isothiocyanate	NN
cord-033493-kslzdy8q	9	8	with	with	IN
cord-033493-kslzdy8q	9	9	ethyl	ethyl	NN
cord-033493-kslzdy8q	9	10	cyanoacetate	cyanoacetate	NN
cord-033493-kslzdy8q	9	11	in	in	IN
cord-033493-kslzdy8q	9	12	KOH	KOH	NNP
cord-033493-kslzdy8q	9	13	–	–	:
cord-033493-kslzdy8q	9	14	EtOH	EtOH	NNP
cord-033493-kslzdy8q	9	15	followed	follow	VBD
cord-033493-kslzdy8q	9	16	by	by	IN
cord-033493-kslzdy8q	9	17	alkylation	alkylation	NN
cord-033493-kslzdy8q	9	18	with	with	IN
cord-033493-kslzdy8q	9	19	methyl	methyl	NN
cord-033493-kslzdy8q	9	20	iodide	iodide	NN
cord-033493-kslzdy8q	9	21	at	at	IN
cord-033493-kslzdy8q	9	22	room	room	NN
cord-033493-kslzdy8q	9	23	temperature	temperature	NN
cord-033493-kslzdy8q	9	24	and	and	CC
cord-033493-kslzdy8q	9	25	then	then	RB
cord-033493-kslzdy8q	9	26	a	a	DT
cord-033493-kslzdy8q	9	27	reaction	reaction	NN
cord-033493-kslzdy8q	9	28	with	with	IN
cord-033493-kslzdy8q	9	29	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	9	30	has	have	VBZ
cord-033493-kslzdy8q	9	31	resulted	result	VBN
cord-033493-kslzdy8q	9	32	in	in	IN
cord-033493-kslzdy8q	9	33	the	the	DT
cord-033493-kslzdy8q	9	34	formation	formation	NN
cord-033493-kslzdy8q	9	35	of	of	IN
cord-033493-kslzdy8q	9	36	3-ethoxy-5-phenyl-1H-1,2,4-triazole	3-ethoxy-5-phenyl-1h-1,2,4-triazole	CD
cord-033493-kslzdy8q	9	37	.	.	.
cord-033493-kslzdy8q	10	1	The	the	DT
cord-033493-kslzdy8q	10	2	structures	structure	NNS
cord-033493-kslzdy8q	10	3	of	of	IN
cord-033493-kslzdy8q	10	4	the	the	DT
cord-033493-kslzdy8q	10	5	new	new	JJ
cord-033493-kslzdy8q	10	6	compounds	compound	NNS
cord-033493-kslzdy8q	10	7	were	be	VBD
cord-033493-kslzdy8q	10	8	characterized	characterize	VBN
cord-033493-kslzdy8q	10	9	by	by	IN
cord-033493-kslzdy8q	10	10	mass	mass	NN
cord-033493-kslzdy8q	10	11	spectroscopy	spectroscopy	NN
cord-033493-kslzdy8q	10	12	,	,	,
cord-033493-kslzdy8q	10	13	(	(	-LRB-
cord-033493-kslzdy8q	10	14	1)H	1)h	CD
cord-033493-kslzdy8q	10	15	nuclear	nuclear	JJ
cord-033493-kslzdy8q	10	16	magnetic	magnetic	JJ
cord-033493-kslzdy8q	10	17	resonance	resonance	NN
cord-033493-kslzdy8q	10	18	(	(	-LRB-
cord-033493-kslzdy8q	10	19	(	(	-LRB-
cord-033493-kslzdy8q	10	20	1)H	1)h	CD
cord-033493-kslzdy8q	10	21	NMR	NMR	NNP
cord-033493-kslzdy8q	10	22	)	)	-RRB-
cord-033493-kslzdy8q	10	23	spectroscopy	spectroscopy	NN
cord-033493-kslzdy8q	10	24	,	,	,
cord-033493-kslzdy8q	10	25	infrared	infrared	JJ
cord-033493-kslzdy8q	10	26	spectroscopy	spectroscopy	NN
cord-033493-kslzdy8q	10	27	(	(	-LRB-
cord-033493-kslzdy8q	10	28	IR	IR	NNP
cord-033493-kslzdy8q	10	29	)	)	-RRB-
cord-033493-kslzdy8q	10	30	,	,	,
cord-033493-kslzdy8q	10	31	and	and	CC
cord-033493-kslzdy8q	10	32	X	x	NN
cord-033493-kslzdy8q	10	33	-	-	NN
cord-033493-kslzdy8q	10	34	ray	ray	JJ
cord-033493-kslzdy8q	10	35	analysis	analysis	NN
cord-033493-kslzdy8q	10	36	.	.	.
cord-033493-kslzdy8q	11	1	The	the	DT
cord-033493-kslzdy8q	11	2	new	new	JJ
cord-033493-kslzdy8q	11	3	compounds	compound	NNS
cord-033493-kslzdy8q	11	4	were	be	VBD
cord-033493-kslzdy8q	11	5	tested	test	VBN
cord-033493-kslzdy8q	11	6	in	in	IN
cord-033493-kslzdy8q	11	7	vitro	vitro	FW
cord-033493-kslzdy8q	11	8	for	for	IN
cord-033493-kslzdy8q	11	9	their	-PRON-	PRP$
cord-033493-kslzdy8q	11	10	anti	anti	JJ
cord-033493-kslzdy8q	11	11	-	-	JJ
cord-033493-kslzdy8q	11	12	influenza	influenza	JJ
cord-033493-kslzdy8q	11	13	A	a	DT
cord-033493-kslzdy8q	11	14	virus	virus	NN
cord-033493-kslzdy8q	11	15	(	(	-LRB-
cord-033493-kslzdy8q	11	16	subtype	subtype	NN
cord-033493-kslzdy8q	11	17	H5N1	H5N1	NNP
cord-033493-kslzdy8q	11	18	)	)	-RRB-
cord-033493-kslzdy8q	11	19	activity	activity	NN
cord-033493-kslzdy8q	11	20	.	.	.
cord-033493-kslzdy8q	12	1	Among	among	IN
cord-033493-kslzdy8q	12	2	the	the	DT
cord-033493-kslzdy8q	12	3	synthesized	synthesize	VBN
cord-033493-kslzdy8q	12	4	compounds	compound	NNS
cord-033493-kslzdy8q	12	5	,	,	,
cord-033493-kslzdy8q	12	6	eight	eight	CD
cord-033493-kslzdy8q	12	7	compounds	compound	NNS
cord-033493-kslzdy8q	12	8	3b	3b	CD
cord-033493-kslzdy8q	12	9	,	,	,
cord-033493-kslzdy8q	12	10	4	4	CD
cord-033493-kslzdy8q	12	11	,	,	,
cord-033493-kslzdy8q	12	12	10b	10b	NNS
cord-033493-kslzdy8q	12	13	,	,	,
cord-033493-kslzdy8q	12	14	10c	10c	CD
cord-033493-kslzdy8q	12	15	,	,	,
cord-033493-kslzdy8q	12	16	12a	12a	NNS
cord-033493-kslzdy8q	12	17	,	,	,
cord-033493-kslzdy8q	12	18	19	19	CD
cord-033493-kslzdy8q	12	19	,	,	,
cord-033493-kslzdy8q	12	20	21a	21a	NNS
cord-033493-kslzdy8q	12	21	,	,	,
cord-033493-kslzdy8q	12	22	and	and	CC
cord-033493-kslzdy8q	12	23	21b	21b	NNS
cord-033493-kslzdy8q	12	24	were	be	VBD
cord-033493-kslzdy8q	12	25	found	find	VBN
cord-033493-kslzdy8q	12	26	to	to	TO
cord-033493-kslzdy8q	12	27	possess	possess	VB
cord-033493-kslzdy8q	12	28	significant	significant	JJ
cord-033493-kslzdy8q	12	29	antiviral	antiviral	JJ
cord-033493-kslzdy8q	12	30	activities	activity	NNS
cord-033493-kslzdy8q	12	31	against	against	IN
cord-033493-kslzdy8q	12	32	bird	bird	NN
cord-033493-kslzdy8q	12	33	flu	flu	NN
cord-033493-kslzdy8q	12	34	influenza	influenza	NN
cord-033493-kslzdy8q	12	35	(	(	-LRB-
cord-033493-kslzdy8q	12	36	H5N1	H5N1	NNP
cord-033493-kslzdy8q	12	37	)	)	-RRB-
cord-033493-kslzdy8q	12	38	with	with	IN
cord-033493-kslzdy8q	12	39	viral	viral	JJ
cord-033493-kslzdy8q	12	40	reduction	reduction	NN
cord-033493-kslzdy8q	12	41	in	in	IN
cord-033493-kslzdy8q	12	42	the	the	DT
cord-033493-kslzdy8q	12	43	range	range	NN
cord-033493-kslzdy8q	12	44	of	of	IN
cord-033493-kslzdy8q	12	45	85–65	85–65	CD
cord-033493-kslzdy8q	12	46	%	%	NN
cord-033493-kslzdy8q	12	47	.	.	.
cord-033493-kslzdy8q	13	1	The	the	DT
cord-033493-kslzdy8q	13	2	emergence	emergence	NN
cord-033493-kslzdy8q	13	3	of	of	IN
cord-033493-kslzdy8q	13	4	bird	bird	NN
cord-033493-kslzdy8q	13	5	flu	flu	NN
cord-033493-kslzdy8q	13	6	virus	virus	NN
cord-033493-kslzdy8q	13	7	(	(	-LRB-
cord-033493-kslzdy8q	13	8	H5N1	H5N1	NNP
cord-033493-kslzdy8q	13	9	)	)	-RRB-
cord-033493-kslzdy8q	13	10	23	23	CD
cord-033493-kslzdy8q	13	11	years	year	NNS
cord-033493-kslzdy8q	13	12	ago	ago	RB
cord-033493-kslzdy8q	13	13	has	have	VBZ
cord-033493-kslzdy8q	13	14	caused	cause	VBN
cord-033493-kslzdy8q	13	15	several	several	JJ
cord-033493-kslzdy8q	13	16	diseases	disease	NNS
cord-033493-kslzdy8q	13	17	in	in	IN
cord-033493-kslzdy8q	13	18	mankind	mankind	NN
cord-033493-kslzdy8q	13	19	over	over	IN
cord-033493-kslzdy8q	13	20	the	the	DT
cord-033493-kslzdy8q	13	21	past	past	JJ
cord-033493-kslzdy8q	13	22	few	few	JJ
cord-033493-kslzdy8q	13	23	years	year	NNS
cord-033493-kslzdy8q	13	24	,	,	,
cord-033493-kslzdy8q	13	25	and	and	CC
cord-033493-kslzdy8q	13	26	now	now	RB
cord-033493-kslzdy8q	13	27	,	,	,
cord-033493-kslzdy8q	13	28	it	-PRON-	PRP
cord-033493-kslzdy8q	13	29	is	be	VBZ
cord-033493-kslzdy8q	13	30	spreading	spread	VBG
cord-033493-kslzdy8q	13	31	in	in	IN
cord-033493-kslzdy8q	13	32	the	the	DT
cord-033493-kslzdy8q	13	33	world	world	NN
cord-033493-kslzdy8q	13	34	a	a	DT
cord-033493-kslzdy8q	13	35	very	very	RB
cord-033493-kslzdy8q	13	36	deadly	deadly	JJ
cord-033493-kslzdy8q	13	37	influenza	influenza	NN
cord-033493-kslzdy8q	13	38	pandemic	pandemic	NN
cord-033493-kslzdy8q	13	39	,	,	,
cord-033493-kslzdy8q	13	40	which	which	WDT
cord-033493-kslzdy8q	13	41	is	be	VBZ
cord-033493-kslzdy8q	13	42	Covid-19	Covid-19	NNP
cord-033493-kslzdy8q	13	43	and	and	CC
cord-033493-kslzdy8q	13	44	has	have	VBZ
cord-033493-kslzdy8q	13	45	caused	cause	VBN
cord-033493-kslzdy8q	13	46	the	the	DT
cord-033493-kslzdy8q	13	47	death	death	NN
cord-033493-kslzdy8q	13	48	of	of	IN
cord-033493-kslzdy8q	13	49	many	many	JJ
cord-033493-kslzdy8q	13	50	people	people	NNS
cord-033493-kslzdy8q	13	51	.	.	.
cord-033493-kslzdy8q	14	1	We	-PRON-	PRP
cord-033493-kslzdy8q	14	2	had	have	VBD
cord-033493-kslzdy8q	14	3	to	to	TO
cord-033493-kslzdy8q	14	4	put	put	VB
cord-033493-kslzdy8q	14	5	in	in	IN
cord-033493-kslzdy8q	14	6	place	place	NN
cord-033493-kslzdy8q	14	7	several	several	JJ
cord-033493-kslzdy8q	14	8	measures	measure	NNS
cord-033493-kslzdy8q	14	9	to	to	TO
cord-033493-kslzdy8q	14	10	prevent	prevent	VB
cord-033493-kslzdy8q	14	11	the	the	DT
cord-033493-kslzdy8q	14	12	spread	spread	NN
cord-033493-kslzdy8q	14	13	of	of	IN
cord-033493-kslzdy8q	14	14	these	these	DT
cord-033493-kslzdy8q	14	15	influenza	influenza	NN
cord-033493-kslzdy8q	14	16	viruses	virus	NNS
cord-033493-kslzdy8q	14	17	by	by	IN
cord-033493-kslzdy8q	14	18	developing	develop	VBG
cord-033493-kslzdy8q	14	19	pharmaceutical	pharmaceutical	JJ
cord-033493-kslzdy8q	14	20	strategies	strategy	NNS
cord-033493-kslzdy8q	14	21	to	to	TO
cord-033493-kslzdy8q	14	22	design	design	VB
cord-033493-kslzdy8q	14	23	drugs	drug	NNS
cord-033493-kslzdy8q	14	24	for	for	IN
cord-033493-kslzdy8q	14	25	combating	combat	VBG
cord-033493-kslzdy8q	14	26	influenza	influenza	NN
cord-033493-kslzdy8q	14	27	viruses	virus	NNS
cord-033493-kslzdy8q	14	28	of	of	IN
cord-033493-kslzdy8q	14	29	all	all	DT
cord-033493-kslzdy8q	14	30	kinds	kind	NNS
cord-033493-kslzdy8q	14	31	.	.	.
cord-033493-kslzdy8q	15	1	5-Aminopyrazoles	5-Aminopyrazoles	NNP
cord-033493-kslzdy8q	15	2	and	and	CC
cord-033493-kslzdy8q	15	3	their	-PRON-	PRP$
cord-033493-kslzdy8q	15	4	fused	fuse	VBN
cord-033493-kslzdy8q	15	5	triazine	triazine	NNP
cord-033493-kslzdy8q	15	6	and	and	CC
cord-033493-kslzdy8q	15	7	pyrimidine	pyrimidine	NN
cord-033493-kslzdy8q	15	8	ring	ring	NN
cord-033493-kslzdy8q	15	9	systems	system	NNS
cord-033493-kslzdy8q	15	10	are	be	VBP
cord-033493-kslzdy8q	15	11	analogs	analog	NNS
cord-033493-kslzdy8q	15	12	of	of	IN
cord-033493-kslzdy8q	15	13	purines	purine	NNS
cord-033493-kslzdy8q	15	14	and	and	CC
cord-033493-kslzdy8q	15	15	thioguanines	thioguanines	NNP
cord-033493-kslzdy8q	15	16	,	,	,
cord-033493-kslzdy8q	15	17	which	which	WDT
cord-033493-kslzdy8q	15	18	are	be	VBP
cord-033493-kslzdy8q	15	19	the	the	DT
cord-033493-kslzdy8q	15	20	mostly	mostly	RB
cord-033493-kslzdy8q	15	21	used	use	VBN
cord-033493-kslzdy8q	15	22	antimetabolic	antimetabolic	JJ
cord-033493-kslzdy8q	15	23	agents	agent	NNS
cord-033493-kslzdy8q	15	24	.	.	.
cord-033493-kslzdy8q	16	1	Pyrazoles	pyrazole	NNS
cord-033493-kslzdy8q	16	2	share	share	VBP
cord-033493-kslzdy8q	16	3	their	-PRON-	PRP$
cord-033493-kslzdy8q	16	4	structural	structural	JJ
cord-033493-kslzdy8q	16	5	design	design	NN
cord-033493-kslzdy8q	16	6	with	with	IN
cord-033493-kslzdy8q	16	7	several	several	JJ
cord-033493-kslzdy8q	16	8	drugs	drug	NNS
cord-033493-kslzdy8q	16	9	,	,	,
cord-033493-kslzdy8q	16	10	and	and	CC
cord-033493-kslzdy8q	16	11	biologically	biologically	RB
cord-033493-kslzdy8q	16	12	dynamic	dynamic	JJ
cord-033493-kslzdy8q	16	13	compounds	compound	NNS
cord-033493-kslzdy8q	16	14	exhibit	exhibit	VBP
cord-033493-kslzdy8q	16	15	activities	activity	NNS
cord-033493-kslzdy8q	16	16	such	such	JJ
cord-033493-kslzdy8q	16	17	as	as	IN
cord-033493-kslzdy8q	16	18	anti	anti	JJ
cord-033493-kslzdy8q	16	19	-	-	JJ
cord-033493-kslzdy8q	16	20	inflammatory	inflammatory	JJ
cord-033493-kslzdy8q	16	21	,	,	,
cord-033493-kslzdy8q	16	22	anticancer	anticancer	JJ
cord-033493-kslzdy8q	16	23	,	,	,
cord-033493-kslzdy8q	16	24	and	and	CC
cord-033493-kslzdy8q	16	25	antihypertensive	antihypertensive	NN
cord-033493-kslzdy8q	16	26	.	.	.
cord-033493-kslzdy8q	17	1	1−3	1−3	CD
cord-033493-kslzdy8q	18	1	Our	-PRON-	PRP$
cord-033493-kslzdy8q	18	2	group	group	NN
cord-033493-kslzdy8q	18	3	has	have	VBZ
cord-033493-kslzdy8q	18	4	actively	actively	RB
cord-033493-kslzdy8q	18	5	embarked	embark	VBN
cord-033493-kslzdy8q	18	6	on	on	IN
cord-033493-kslzdy8q	18	7	a	a	DT
cord-033493-kslzdy8q	18	8	program	program	NN
cord-033493-kslzdy8q	18	9	for	for	IN
cord-033493-kslzdy8q	18	10	the	the	DT
cord-033493-kslzdy8q	18	11	development	development	NN
cord-033493-kslzdy8q	18	12	of	of	IN
cord-033493-kslzdy8q	18	13	new	new	JJ
cord-033493-kslzdy8q	18	14	methods	method	NNS
cord-033493-kslzdy8q	18	15	for	for	IN
cord-033493-kslzdy8q	18	16	the	the	DT
cord-033493-kslzdy8q	18	17	synthesis	synthesis	NN
cord-033493-kslzdy8q	18	18	of	of	IN
cord-033493-kslzdy8q	18	19	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	18	20	as	as	IN
cord-033493-kslzdy8q	18	21	potential	potential	JJ
cord-033493-kslzdy8q	18	22	bioactive	bioactive	JJ
cord-033493-kslzdy8q	18	23	agents	agent	NNS
cord-033493-kslzdy8q	18	24	.	.	.
cord-033493-kslzdy8q	19	1	4,5	4,5	LS
cord-033493-kslzdy8q	19	2	5-Aminoyrazoles	5-aminoyrazoles	CD
cord-033493-kslzdy8q	19	3	have	have	VBP
cord-033493-kslzdy8q	19	4	been	be	VBN
cord-033493-kslzdy8q	19	5	used	use	VBN
cord-033493-kslzdy8q	19	6	to	to	TO
cord-033493-kslzdy8q	19	7	synthesize	synthesize	VB
cord-033493-kslzdy8q	19	8	numerous	numerous	JJ
cord-033493-kslzdy8q	19	9	other	other	JJ
cord-033493-kslzdy8q	19	10	fused	fuse	VBN
cord-033493-kslzdy8q	19	11	heterocycles	heterocycle	NNS
cord-033493-kslzdy8q	19	12	.	.	.
cord-033493-kslzdy8q	20	1	Pyrazolo	Pyrazolo	NNP
cord-033493-kslzdy8q	20	2	[	[	-LRB-
cord-033493-kslzdy8q	20	3	1,5-a	1,5-a	CD
cord-033493-kslzdy8q	20	4	]	]	-RRB-
cord-033493-kslzdy8q	20	5	pyrimidines	pyrimidine	NNS
cord-033493-kslzdy8q	20	6	,	,	,
cord-033493-kslzdy8q	20	7	in	in	IN
cord-033493-kslzdy8q	20	8	particular	particular	JJ
cord-033493-kslzdy8q	20	9	,	,	,
cord-033493-kslzdy8q	20	10	have	have	VBP
cord-033493-kslzdy8q	20	11	shown	show	VBN
cord-033493-kslzdy8q	20	12	valuable	valuable	JJ
cord-033493-kslzdy8q	20	13	pharmaceutical	pharmaceutical	NN
cord-033493-kslzdy8q	20	14	uses	use	NNS
cord-033493-kslzdy8q	20	15	including	include	VBG
cord-033493-kslzdy8q	20	16	various	various	JJ
cord-033493-kslzdy8q	20	17	antiviral	antiviral	JJ
cord-033493-kslzdy8q	20	18	,	,	,
cord-033493-kslzdy8q	20	19	antimicrobial	antimicrobial	JJ
cord-033493-kslzdy8q	20	20	,	,	,
cord-033493-kslzdy8q	20	21	and	and	CC
cord-033493-kslzdy8q	20	22	antitumor	antitumor	JJ
cord-033493-kslzdy8q	20	23	activities	activity	NNS
cord-033493-kslzdy8q	20	24	.	.	.
cord-033493-kslzdy8q	21	1	6−11	6−11	CD
cord-033493-kslzdy8q	22	1	Some	some	DT
cord-033493-kslzdy8q	22	2	compounds	compound	NNS
cord-033493-kslzdy8q	22	3	comprising	comprise	VBG
cord-033493-kslzdy8q	22	4	this	this	DT
cord-033493-kslzdy8q	22	5	scaffold	scaffold	NN
cord-033493-kslzdy8q	22	6	are	be	VBP
cord-033493-kslzdy8q	22	7	official	official	JJ
cord-033493-kslzdy8q	22	8	and	and	CC
cord-033493-kslzdy8q	22	9	commercialized	commercialize	VBN
cord-033493-kslzdy8q	22	10	drugs	drug	NNS
cord-033493-kslzdy8q	22	11	,	,	,
cord-033493-kslzdy8q	22	12	for	for	IN
cord-033493-kslzdy8q	22	13	example	example	NN
cord-033493-kslzdy8q	22	14	,	,	,
cord-033493-kslzdy8q	22	15	zaleplon	zaleplon	NNP
cord-033493-kslzdy8q	22	16	(	(	-LRB-
cord-033493-kslzdy8q	22	17	A	A	NNP
cord-033493-kslzdy8q	22	18	)	)	-RRB-
cord-033493-kslzdy8q	22	19	,	,	,
cord-033493-kslzdy8q	22	20	lorediplon	lorediplon	NNP
cord-033493-kslzdy8q	22	21	(	(	-LRB-
cord-033493-kslzdy8q	22	22	B	B	NNP
cord-033493-kslzdy8q	22	23	)	)	-RRB-
cord-033493-kslzdy8q	22	24	,	,	,
cord-033493-kslzdy8q	22	25	indiplon	indiplon	NNP
cord-033493-kslzdy8q	22	26	(	(	-LRB-
cord-033493-kslzdy8q	22	27	C	C	NNP
cord-033493-kslzdy8q	22	28	)	)	-RRB-
cord-033493-kslzdy8q	22	29	,	,	,
cord-033493-kslzdy8q	22	30	anagliptin	anagliptin	NNP
cord-033493-kslzdy8q	22	31	(	(	-LRB-
cord-033493-kslzdy8q	22	32	D	D	NNP
cord-033493-kslzdy8q	22	33	)	)	-RRB-
cord-033493-kslzdy8q	22	34	,	,	,
cord-033493-kslzdy8q	22	35	and	and	CC
cord-033493-kslzdy8q	22	36	ocinaplon	ocinaplon	JJ
cord-033493-kslzdy8q	22	37	(	(	-LRB-
cord-033493-kslzdy8q	22	38	E	e	NN
cord-033493-kslzdy8q	22	39	)	)	-RRB-
cord-033493-kslzdy8q	22	40	(	(	-LRB-
cord-033493-kslzdy8q	22	41	Figure	figure	NN
cord-033493-kslzdy8q	22	42	1	1	CD
cord-033493-kslzdy8q	22	43	)	)	-RRB-
cord-033493-kslzdy8q	22	44	.	.	.
cord-033493-kslzdy8q	23	1	We	-PRON-	PRP
cord-033493-kslzdy8q	23	2	have	have	VBP
cord-033493-kslzdy8q	23	3	recently	recently	RB
cord-033493-kslzdy8q	23	4	reported	report	VBN
cord-033493-kslzdy8q	23	5	different	different	JJ
cord-033493-kslzdy8q	23	6	successful	successful	JJ
cord-033493-kslzdy8q	23	7	synthetic	synthetic	JJ
cord-033493-kslzdy8q	23	8	methods	method	NNS
cord-033493-kslzdy8q	23	9	to	to	TO
cord-033493-kslzdy8q	23	10	prepare	prepare	VB
cord-033493-kslzdy8q	23	11	pyrazolo	pyrazolo	NNP
cord-033493-kslzdy8q	23	12	[	[	-LRB-
cord-033493-kslzdy8q	23	13	1,5-a	1,5-a	CD
cord-033493-kslzdy8q	23	14	]	]	-RRB-
cord-033493-kslzdy8q	23	15	pyrimidines	pyrimidine	NNS
cord-033493-kslzdy8q	23	16	,	,	,
cord-033493-kslzdy8q	23	17	which	which	WDT
cord-033493-kslzdy8q	23	18	found	find	VBD
cord-033493-kslzdy8q	23	19	application	application	NN
cord-033493-kslzdy8q	23	20	and	and	CC
cord-033493-kslzdy8q	23	21	appear	appear	VBP
cord-033493-kslzdy8q	23	22	to	to	TO
cord-033493-kslzdy8q	23	23	constitute	constitute	VB
cord-033493-kslzdy8q	23	24	new	new	JJ
cord-033493-kslzdy8q	23	25	classes	class	NNS
cord-033493-kslzdy8q	23	26	of	of	IN
cord-033493-kslzdy8q	23	27	antimetabolic	antimetabolic	JJ
cord-033493-kslzdy8q	23	28	agents	agent	NNS
cord-033493-kslzdy8q	23	29	.	.	.
cord-033493-kslzdy8q	24	1	12−15	12−15	LS
cord-033493-kslzdy8q	24	2	Pyrazolo	Pyrazolo	NNP
cord-033493-kslzdy8q	24	3	[	[	-LRB-
cord-033493-kslzdy8q	24	4	5,1-c	5,1-c	CD
cord-033493-kslzdy8q	24	5	]	]	-RRB-
cord-033493-kslzdy8q	24	6	triazines	triazine	NNS
cord-033493-kslzdy8q	24	7	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	24	8	of	of	IN
cord-033493-kslzdy8q	24	9	3-ethoxy-5-phenyl	3-ethoxy-5-phenyl	CD
cord-033493-kslzdy8q	24	10	include	include	VBP
cord-033493-kslzdy8q	24	11	a	a	DT
cord-033493-kslzdy8q	24	12	large	large	JJ
cord-033493-kslzdy8q	24	13	number	number	NN
cord-033493-kslzdy8q	24	14	of	of	IN
cord-033493-kslzdy8q	24	15	compounds	compound	NNS
cord-033493-kslzdy8q	24	16	with	with	IN
cord-033493-kslzdy8q	24	17	broad	broad	JJ
cord-033493-kslzdy8q	24	18	biological	biological	JJ
cord-033493-kslzdy8q	24	19	activities	activity	NNS
cord-033493-kslzdy8q	24	20	.	.	.
cord-033493-kslzdy8q	25	1	The	the	DT
cord-033493-kslzdy8q	25	2	pyrazolo	pyrazolo	NN
cord-033493-kslzdy8q	25	3	[	[	-LRB-
cord-033493-kslzdy8q	25	4	5,1-c	5,1-c	CD
cord-033493-kslzdy8q	25	5	]	]	-RRB-
cord-033493-kslzdy8q	25	6	triazines	triazine	NNS
cord-033493-kslzdy8q	25	7	are	be	VBP
cord-033493-kslzdy8q	25	8	well	well	RB
cord-033493-kslzdy8q	25	9	known	know	VBN
cord-033493-kslzdy8q	25	10	as	as	IN
cord-033493-kslzdy8q	25	11	the	the	DT
cord-033493-kslzdy8q	25	12	most	most	RBS
cord-033493-kslzdy8q	25	13	potent	potent	JJ
cord-033493-kslzdy8q	25	14	scaffold	scaffold	NN
cord-033493-kslzdy8q	25	15	for	for	IN
cord-033493-kslzdy8q	25	16	synthesizing	synthesize	VBG
cord-033493-kslzdy8q	25	17	potential	potential	JJ
cord-033493-kslzdy8q	25	18	therapeutics	therapeutic	NNS
cord-033493-kslzdy8q	25	19	.	.	.
cord-033493-kslzdy8q	26	1	The	the	DT
cord-033493-kslzdy8q	26	2	applications	application	NNS
cord-033493-kslzdy8q	26	3	of	of	IN
cord-033493-kslzdy8q	26	4	these	these	DT
cord-033493-kslzdy8q	26	5	ring	ring	NN
cord-033493-kslzdy8q	26	6	systems	system	NNS
cord-033493-kslzdy8q	26	7	as	as	IN
cord-033493-kslzdy8q	26	8	kinase	kinase	NN
cord-033493-kslzdy8q	26	9	inhibitors	inhibitor	NNS
cord-033493-kslzdy8q	26	10	are	be	VBP
cord-033493-kslzdy8q	26	11	growing	grow	VBG
cord-033493-kslzdy8q	26	12	and	and	CC
cord-033493-kslzdy8q	26	13	are	be	VBP
cord-033493-kslzdy8q	26	14	very	very	RB
cord-033493-kslzdy8q	26	15	successful	successful	JJ
cord-033493-kslzdy8q	26	16	in	in	IN
cord-033493-kslzdy8q	26	17	the	the	DT
cord-033493-kslzdy8q	26	18	last	last	JJ
cord-033493-kslzdy8q	26	19	few	few	JJ
cord-033493-kslzdy8q	26	20	years	year	NNS
cord-033493-kslzdy8q	26	21	.	.	.
cord-033493-kslzdy8q	27	1	16−19	16−19	LS
cord-033493-kslzdy8q	27	2	We	-PRON-	PRP
cord-033493-kslzdy8q	27	3	have	have	VBP
cord-033493-kslzdy8q	27	4	recently	recently	RB
cord-033493-kslzdy8q	27	5	reported	report	VBN
cord-033493-kslzdy8q	27	6	different	different	JJ
cord-033493-kslzdy8q	27	7	successful	successful	JJ
cord-033493-kslzdy8q	27	8	synthetic	synthetic	JJ
cord-033493-kslzdy8q	27	9	methods	method	NNS
cord-033493-kslzdy8q	27	10	to	to	TO
cord-033493-kslzdy8q	27	11	prepare	prepare	VB
cord-033493-kslzdy8q	27	12	pyrazolotriazines	pyrazolotriazine	NNS
cord-033493-kslzdy8q	27	13	,	,	,
cord-033493-kslzdy8q	27	14	which	which	WDT
cord-033493-kslzdy8q	27	15	found	find	VBD
cord-033493-kslzdy8q	27	16	application	application	NN
cord-033493-kslzdy8q	27	17	and	and	CC
cord-033493-kslzdy8q	27	18	appear	appear	VBP
cord-033493-kslzdy8q	27	19	to	to	TO
cord-033493-kslzdy8q	27	20	constitute	constitute	VB
cord-033493-kslzdy8q	27	21	new	new	JJ
cord-033493-kslzdy8q	27	22	classes	class	NNS
cord-033493-kslzdy8q	27	23	of	of	IN
cord-033493-kslzdy8q	27	24	antimetabolic	antimetabolic	JJ
cord-033493-kslzdy8q	27	25	agents	agent	NNS
cord-033493-kslzdy8q	27	26	.	.	.
cord-033493-kslzdy8q	28	1	20	20	CD
cord-033493-kslzdy8q	28	2	,	,	,
cord-033493-kslzdy8q	28	3	21	21	CD
cord-033493-kslzdy8q	28	4	One	one	CD
cord-033493-kslzdy8q	28	5	of	of	IN
cord-033493-kslzdy8q	28	6	our	-PRON-	PRP$
cord-033493-kslzdy8q	28	7	previously	previously	RB
cord-033493-kslzdy8q	28	8	reported	report	VBN
cord-033493-kslzdy8q	28	9	series	series	NN
cord-033493-kslzdy8q	28	10	of	of	IN
cord-033493-kslzdy8q	28	11	novel	novel	JJ
cord-033493-kslzdy8q	28	12	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	28	13	F	F	NNP
cord-033493-kslzdy8q	28	14	and	and	CC
cord-033493-kslzdy8q	28	15	G	G	NNP
cord-033493-kslzdy8q	28	16	(	(	-LRB-
cord-033493-kslzdy8q	28	17	Figure	figure	NN
cord-033493-kslzdy8q	28	18	2	2	CD
cord-033493-kslzdy8q	28	19	)	)	-RRB-
cord-033493-kslzdy8q	28	20	was	be	VBD
cord-033493-kslzdy8q	28	21	used	use	VBN
cord-033493-kslzdy8q	28	22	by	by	IN
cord-033493-kslzdy8q	28	23	others	other	NNS
cord-033493-kslzdy8q	28	24	as	as	IN
cord-033493-kslzdy8q	28	25	a	a	DT
cord-033493-kslzdy8q	28	26	starting	starting	NN
cord-033493-kslzdy8q	28	27	material	material	NN
cord-033493-kslzdy8q	28	28	for	for	IN
cord-033493-kslzdy8q	28	29	the	the	DT
cord-033493-kslzdy8q	28	30	synthesis	synthesis	NN
cord-033493-kslzdy8q	28	31	of	of	IN
cord-033493-kslzdy8q	28	32	pyrazolopyrimidines	pyrazolopyrimidine	NNS
cord-033493-kslzdy8q	28	33	.	.	.
cord-033493-kslzdy8q	29	1	22−27	22−27	NNP
cord-033493-kslzdy8q	29	2	Studies	Studies	NNPS
cord-033493-kslzdy8q	29	3	revealed	reveal	VBD
cord-033493-kslzdy8q	29	4	that	that	IN
cord-033493-kslzdy8q	29	5	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	29	6	act	act	NN
cord-033493-kslzdy8q	29	7	as	as	IN
cord-033493-kslzdy8q	29	8	a	a	DT
cord-033493-kslzdy8q	29	9	building	building	NN
cord-033493-kslzdy8q	29	10	block	block	NN
cord-033493-kslzdy8q	29	11	for	for	IN
cord-033493-kslzdy8q	29	12	various	various	JJ
cord-033493-kslzdy8q	29	13	functionalized	functionalize	VBN
cord-033493-kslzdy8q	29	14	pyrazolopyrimidines	pyrazolopyrimidine	NNS
cord-033493-kslzdy8q	29	15	as	as	IN
cord-033493-kslzdy8q	29	16	purine	purine	NN
cord-033493-kslzdy8q	29	17	analogs	analog	NNS
cord-033493-kslzdy8q	29	18	.	.	.
cord-033493-kslzdy8q	30	1	28−37	28−37	CD
cord-033493-kslzdy8q	31	1	These	these	DT
cord-033493-kslzdy8q	31	2	interesting	interesting	JJ
cord-033493-kslzdy8q	31	3	results	result	NNS
cord-033493-kslzdy8q	31	4	have	have	VBP
cord-033493-kslzdy8q	31	5	promoted	promote	VBN
cord-033493-kslzdy8q	31	6	our	-PRON-	PRP$
cord-033493-kslzdy8q	31	7	research	research	NN
cord-033493-kslzdy8q	31	8	group	group	NN
cord-033493-kslzdy8q	31	9	to	to	TO
cord-033493-kslzdy8q	31	10	explore	explore	VB
cord-033493-kslzdy8q	31	11	other	other	JJ
cord-033493-kslzdy8q	31	12	synthetic	synthetic	JJ
cord-033493-kslzdy8q	31	13	methods	method	NNS
cord-033493-kslzdy8q	31	14	for	for	IN
cord-033493-kslzdy8q	31	15	the	the	DT
cord-033493-kslzdy8q	31	16	preparation	preparation	NN
cord-033493-kslzdy8q	31	17	of	of	IN
cord-033493-kslzdy8q	31	18	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	31	19	for	for	IN
cord-033493-kslzdy8q	31	20	synthesizing	synthesize	VBG
cord-033493-kslzdy8q	31	21	pyrazolotriazines	pyrazolotriazine	NNS
cord-033493-kslzdy8q	31	22	and	and	CC
cord-033493-kslzdy8q	31	23	pyrazolopyrimidines	pyrazolopyrimidine	NNS
cord-033493-kslzdy8q	31	24	and	and	CC
cord-033493-kslzdy8q	31	25	investigating	investigate	VBG
cord-033493-kslzdy8q	31	26	their	-PRON-	PRP$
cord-033493-kslzdy8q	31	27	use	use	NN
cord-033493-kslzdy8q	31	28	as	as	IN
cord-033493-kslzdy8q	31	29	antiviral	antiviral	JJ
cord-033493-kslzdy8q	31	30	agents	agent	NNS
cord-033493-kslzdy8q	31	31	in	in	IN
cord-033493-kslzdy8q	31	32	chemotherapy	chemotherapy	NN
cord-033493-kslzdy8q	31	33	.	.	.
cord-033493-kslzdy8q	32	1	In	in	IN
cord-033493-kslzdy8q	32	2	light	light	NN
cord-033493-kslzdy8q	32	3	of	of	IN
cord-033493-kslzdy8q	32	4	these	these	DT
cord-033493-kslzdy8q	32	5	results	result	NNS
cord-033493-kslzdy8q	32	6	and	and	CC
cord-033493-kslzdy8q	32	7	as	as	IN
cord-033493-kslzdy8q	32	8	part	part	NN
cord-033493-kslzdy8q	32	9	of	of	IN
cord-033493-kslzdy8q	32	10	our	-PRON-	PRP$
cord-033493-kslzdy8q	32	11	program	program	NN
cord-033493-kslzdy8q	32	12	directed	direct	VBN
cord-033493-kslzdy8q	32	13	toward	toward	IN
cord-033493-kslzdy8q	32	14	the	the	DT
cord-033493-kslzdy8q	32	15	preparation	preparation	NN
cord-033493-kslzdy8q	32	16	of	of	IN
cord-033493-kslzdy8q	32	17	potential	potential	JJ
cord-033493-kslzdy8q	32	18	antiviral	antiviral	JJ
cord-033493-kslzdy8q	32	19	antibiotics	antibiotic	NNS
cord-033493-kslzdy8q	32	20	,	,	,
cord-033493-kslzdy8q	32	21	the	the	DT
cord-033493-kslzdy8q	32	22	present	present	JJ
cord-033493-kslzdy8q	32	23	paper	paper	NN
cord-033493-kslzdy8q	32	24	deals	deal	NNS
cord-033493-kslzdy8q	32	25	with	with	IN
cord-033493-kslzdy8q	32	26	a	a	DT
cord-033493-kslzdy8q	32	27	novel	novel	JJ
cord-033493-kslzdy8q	32	28	synthesis	synthesis	NN
cord-033493-kslzdy8q	32	29	of	of	IN
cord-033493-kslzdy8q	32	30	novel	novel	JJ
cord-033493-kslzdy8q	32	31	benzamide	benzamide	NN
cord-033493-kslzdy8q	32	32	-	-	HYPH
cord-033493-kslzdy8q	32	33	based	base	VBN
cord-033493-kslzdy8q	32	34	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	32	35	and	and	CC
cord-033493-kslzdy8q	32	36	their	-PRON-	PRP$
cord-033493-kslzdy8q	32	37	use	use	NN
cord-033493-kslzdy8q	32	38	in	in	IN
cord-033493-kslzdy8q	32	39	synthesizing	synthesize	VBG
cord-033493-kslzdy8q	32	40	pyrazolo-	pyrazolo-	NN
cord-033493-kslzdy8q	32	41	[	[	-LRB-
cord-033493-kslzdy8q	32	42	5,1-c	5,1-c	CD
cord-033493-kslzdy8q	32	43	]	]	-RRB-
cord-033493-kslzdy8q	32	44	triazine	triazine	NNP
cord-033493-kslzdy8q	32	45	and	and	CC
cord-033493-kslzdy8q	32	46	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	JJ
cord-033493-kslzdy8q	32	47	ring	ring	NN
cord-033493-kslzdy8q	32	48	systems	system	NNS
cord-033493-kslzdy8q	32	49	using	use	VBG
cord-033493-kslzdy8q	32	50	innovative	innovative	JJ
cord-033493-kslzdy8q	32	51	synthetic	synthetic	JJ
cord-033493-kslzdy8q	32	52	approaches	approach	NNS
cord-033493-kslzdy8q	32	53	.	.	.
cord-033493-kslzdy8q	33	1	Chemistry	chemistry	NN
cord-033493-kslzdy8q	33	2	.	.	.
cord-033493-kslzdy8q	34	1	It	-PRON-	PRP
cord-033493-kslzdy8q	34	2	has	have	VBZ
cord-033493-kslzdy8q	34	3	been	be	VBN
cord-033493-kslzdy8q	34	4	found	find	VBN
cord-033493-kslzdy8q	34	5	that	that	IN
cord-033493-kslzdy8q	34	6	benzoyl	benzoyl	NN
cord-033493-kslzdy8q	34	7	isothiocyanate	isothiocyanate	NN
cord-033493-kslzdy8q	34	8	reacted	react	VBD
cord-033493-kslzdy8q	34	9	with	with	IN
cord-033493-kslzdy8q	34	10	malononitrile	malononitrile	NN
cord-033493-kslzdy8q	34	11	in	in	IN
cord-033493-kslzdy8q	34	12	potassium	potassium	NN
cord-033493-kslzdy8q	34	13	hydroxide−ethanol	hydroxide−ethanol	NN
cord-033493-kslzdy8q	34	14	with	with	IN
cord-033493-kslzdy8q	34	15	heating	heating	NN
cord-033493-kslzdy8q	34	16	to	to	TO
cord-033493-kslzdy8q	34	17	give	give	VB
cord-033493-kslzdy8q	34	18	the	the	DT
cord-033493-kslzdy8q	34	19	corresponding	correspond	VBG
cord-033493-kslzdy8q	34	20	stable	stable	JJ
cord-033493-kslzdy8q	34	21	potassium	potassium	NN
cord-033493-kslzdy8q	34	22	2cyano	2cyano	CD
cord-033493-kslzdy8q	34	23	-	-	:
cord-033493-kslzdy8q	34	24	ethylene-1-thiolate	ethylene-1-thiolate	NN
cord-033493-kslzdy8q	34	25	salt	salt	NN
cord-033493-kslzdy8q	34	26	2	2	CD
cord-033493-kslzdy8q	34	27	.	.	.
cord-033493-kslzdy8q	35	1	5-Aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	35	2	4	4	CD
cord-033493-kslzdy8q	35	3	was	be	VBD
cord-033493-kslzdy8q	35	4	prepared	prepare	VBN
cord-033493-kslzdy8q	35	5	by	by	IN
cord-033493-kslzdy8q	35	6	alkylation	alkylation	NN
cord-033493-kslzdy8q	35	7	of	of	IN
cord-033493-kslzdy8q	35	8	the	the	DT
cord-033493-kslzdy8q	35	9	potassium	potassium	NN
cord-033493-kslzdy8q	35	10	2-cyano	2-cyano	CD
cord-033493-kslzdy8q	35	11	-	-	HYPH
cord-033493-kslzdy8q	35	12	ethylene-1thiolate	ethylene-1thiolate	NN
cord-033493-kslzdy8q	35	13	salt	salt	NN
cord-033493-kslzdy8q	35	14	2	2	CD
cord-033493-kslzdy8q	35	15	with	with	IN
cord-033493-kslzdy8q	35	16	an	an	DT
cord-033493-kslzdy8q	35	17	alkyl	alkyl	JJ
cord-033493-kslzdy8q	35	18	halide	halide	NN
cord-033493-kslzdy8q	35	19	at	at	IN
cord-033493-kslzdy8q	35	20	room	room	NN
cord-033493-kslzdy8q	35	21	temperature	temperature	NN
cord-033493-kslzdy8q	35	22	to	to	TO
cord-033493-kslzdy8q	35	23	offer	offer	VB
cord-033493-kslzdy8q	35	24	N-(2,2-dicyano-1-(alkylthio)vinyl)benzamide	N-(2,2-dicyano-1-(alkylthio)vinyl)benzamide	NNP
cord-033493-kslzdy8q	35	25	3	3	CD
cord-033493-kslzdy8q	35	26	followed	follow	VBN
cord-033493-kslzdy8q	35	27	by	by	IN
cord-033493-kslzdy8q	35	28	a	a	DT
cord-033493-kslzdy8q	35	29	reaction	reaction	NN
cord-033493-kslzdy8q	35	30	with	with	IN
cord-033493-kslzdy8q	35	31	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	35	32	hydrate	hydrate	NN
cord-033493-kslzdy8q	35	33	by	by	IN
cord-033493-kslzdy8q	35	34	refluxing	refluxe	VBG
cord-033493-kslzdy8q	35	35	ethanol	ethanol	NN
cord-033493-kslzdy8q	35	36	containing	contain	VBG
cord-033493-kslzdy8q	35	37	a	a	DT
cord-033493-kslzdy8q	35	38	catalytic	catalytic	JJ
cord-033493-kslzdy8q	35	39	amount	amount	NN
cord-033493-kslzdy8q	35	40	of	of	IN
cord-033493-kslzdy8q	35	41	piperidine	piperidine	NN
cord-033493-kslzdy8q	35	42	(	(	-LRB-
cord-033493-kslzdy8q	35	43	Scheme	scheme	NN
cord-033493-kslzdy8q	35	44	1	1	CD
cord-033493-kslzdy8q	35	45	)	)	-RRB-
cord-033493-kslzdy8q	35	46	.	.	.
cord-033493-kslzdy8q	36	1	The	the	DT
cord-033493-kslzdy8q	36	2	structures	structure	NNS
cord-033493-kslzdy8q	36	3	of	of	IN
cord-033493-kslzdy8q	36	4	3	3	CD
cord-033493-kslzdy8q	36	5	and	and	CC
cord-033493-kslzdy8q	36	6	4	4	CD
cord-033493-kslzdy8q	36	7	were	be	VBD
cord-033493-kslzdy8q	36	8	established	establish	VBN
cord-033493-kslzdy8q	36	9	on	on	IN
cord-033493-kslzdy8q	36	10	the	the	DT
cord-033493-kslzdy8q	36	11	basis	basis	NN
cord-033493-kslzdy8q	36	12	of	of	IN
cord-033493-kslzdy8q	36	13	their	-PRON-	PRP$
cord-033493-kslzdy8q	36	14	elemental	elemental	JJ
cord-033493-kslzdy8q	36	15	analysis	analysis	NN
cord-033493-kslzdy8q	36	16	and	and	CC
cord-033493-kslzdy8q	36	17	spectral	spectral	JJ
cord-033493-kslzdy8q	36	18	data	datum	NNS
cord-033493-kslzdy8q	36	19	(	(	-LRB-
cord-033493-kslzdy8q	36	20	IR	IR	NNP
cord-033493-kslzdy8q	36	21	,	,	,
cord-033493-kslzdy8q	36	22	13	13	CD
cord-033493-kslzdy8q	36	23	C	c	NN
cord-033493-kslzdy8q	36	24	NMR	NMR	NNP
cord-033493-kslzdy8q	36	25	,	,	,
cord-033493-kslzdy8q	36	26	1	1	CD
cord-033493-kslzdy8q	36	27	H	h	NN
cord-033493-kslzdy8q	36	28	NMR	nmr	NN
cord-033493-kslzdy8q	36	29	,	,	,
cord-033493-kslzdy8q	36	30	and	and	CC
cord-033493-kslzdy8q	36	31	MS	MS	NNP
cord-033493-kslzdy8q	36	32	)	)	-RRB-
cord-033493-kslzdy8q	36	33	.	.	.
cord-033493-kslzdy8q	37	1	Structure	structure	NN
cord-033493-kslzdy8q	37	2	4	4	CD
cord-033493-kslzdy8q	37	3	was	be	VBD
cord-033493-kslzdy8q	37	4	confirmed	confirm	VBN
cord-033493-kslzdy8q	37	5	by	by	IN
cord-033493-kslzdy8q	37	6	its	-PRON-	PRP$
cord-033493-kslzdy8q	37	7	mass	mass	NN
cord-033493-kslzdy8q	37	8	(	(	-LRB-
cord-033493-kslzdy8q	37	9	m	m	NNP
cord-033493-kslzdy8q	37	10	/	/	SYM
cord-033493-kslzdy8q	37	11	z	z	NNP
cord-033493-kslzdy8q	37	12	227	227	CD
cord-033493-kslzdy8q	37	13	)	)	-RRB-
cord-033493-kslzdy8q	37	14	,	,	,
cord-033493-kslzdy8q	37	15	which	which	WDT
cord-033493-kslzdy8q	37	16	agrees	agree	VBZ
cord-033493-kslzdy8q	37	17	with	with	IN
cord-033493-kslzdy8q	37	18	its	-PRON-	PRP$
cord-033493-kslzdy8q	37	19	molecular	molecular	JJ
cord-033493-kslzdy8q	37	20	formula	formula	NN
cord-033493-kslzdy8q	37	21	C	c	NN
cord-033493-kslzdy8q	37	22	11	11	CD
cord-033493-kslzdy8q	37	23	H	H	NNP
cord-033493-kslzdy8q	37	24	9	9	CD
cord-033493-kslzdy8q	37	25	N	n	CD
cord-033493-kslzdy8q	37	26	5	5	CD
cord-033493-kslzdy8q	37	27	O.	o.	NN
cord-033493-kslzdy8q	38	1	The	the	DT
cord-033493-kslzdy8q	38	2	1	1	CD
cord-033493-kslzdy8q	38	3	H	h	NN
cord-033493-kslzdy8q	38	4	NMR	nmr	NN
cord-033493-kslzdy8q	38	5	spectrum	spectrum	NN
cord-033493-kslzdy8q	38	6	of	of	IN
cord-033493-kslzdy8q	38	7	compound	compound	NN
cord-033493-kslzdy8q	38	8	4	4	CD
cord-033493-kslzdy8q	38	9	revealed	reveal	VBD
cord-033493-kslzdy8q	38	10	a	a	DT
cord-033493-kslzdy8q	38	11	broad	broad	JJ
cord-033493-kslzdy8q	38	12	singlet	singlet	NN
cord-033493-kslzdy8q	38	13	at	at	IN
cord-033493-kslzdy8q	38	14	5.37	5.37	CD
cord-033493-kslzdy8q	38	15	ppm	ppm	NN
cord-033493-kslzdy8q	38	16	for	for	IN
cord-033493-kslzdy8q	38	17	the	the	DT
cord-033493-kslzdy8q	38	18	NH	NH	NNP
cord-033493-kslzdy8q	38	19	2	2	CD
cord-033493-kslzdy8q	38	20	group	group	NN
cord-033493-kslzdy8q	38	21	,	,	,
cord-033493-kslzdy8q	38	22	a	a	DT
cord-033493-kslzdy8q	38	23	multiplet	multiplet	NN
cord-033493-kslzdy8q	38	24	at	at	IN
cord-033493-kslzdy8q	38	25	a	a	DT
cord-033493-kslzdy8q	38	26	range	range	NN
cord-033493-kslzdy8q	38	27	of	of	IN
cord-033493-kslzdy8q	38	28	7.50−8.09	7.50−8.09	CD
cord-033493-kslzdy8q	38	29	ppm	ppm	NN
cord-033493-kslzdy8q	38	30	for	for	IN
cord-033493-kslzdy8q	38	31	the	the	DT
cord-033493-kslzdy8q	38	32	phenyl	phenyl	NNP
cord-033493-kslzdy8q	38	33	moiety	moiety	NN
cord-033493-kslzdy8q	38	34	,	,	,
cord-033493-kslzdy8q	38	35	and	and	CC
cord-033493-kslzdy8q	38	36	two	two	CD
cord-033493-kslzdy8q	38	37	broad	broad	JJ
cord-033493-kslzdy8q	38	38	singlets	singlet	NNS
cord-033493-kslzdy8q	38	39	at	at	IN
cord-033493-kslzdy8q	38	40	11.73	11.73	CD
cord-033493-kslzdy8q	38	41	and	and	CC
cord-033493-kslzdy8q	38	42	12.33	12.33	CD
cord-033493-kslzdy8q	38	43	ppm	ppm	NN
cord-033493-kslzdy8q	38	44	assigned	assign	VBN
cord-033493-kslzdy8q	38	45	to	to	IN
cord-033493-kslzdy8q	38	46	two	two	CD
cord-033493-kslzdy8q	38	47	NH	NH	NNP
cord-033493-kslzdy8q	38	48	groups	group	NNS
cord-033493-kslzdy8q	38	49	.	.	.
cord-033493-kslzdy8q	39	1	The	the	DT
cord-033493-kslzdy8q	39	2	reactivity	reactivity	NN
cord-033493-kslzdy8q	39	3	of	of	IN
cord-033493-kslzdy8q	39	4	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	39	5	derivative	derivative	JJ
cord-033493-kslzdy8q	39	6	4	4	CD
cord-033493-kslzdy8q	39	7	to	to	TO
cord-033493-kslzdy8q	39	8	form	form	VB
cord-033493-kslzdy8q	39	9	the	the	DT
cord-033493-kslzdy8q	39	10	diazonium	diazonium	NN
cord-033493-kslzdy8q	39	11	salt	salt	NN
cord-033493-kslzdy8q	39	12	5	5	CD
cord-033493-kslzdy8q	39	13	was	be	VBD
cord-033493-kslzdy8q	39	14	studied	study	VBN
cord-033493-kslzdy8q	39	15	,	,	,
cord-033493-kslzdy8q	39	16	and	and	CC
cord-033493-kslzdy8q	39	17	the	the	DT
cord-033493-kslzdy8q	39	18	latter	latter	JJ
cord-033493-kslzdy8q	39	19	was	be	VBD
cord-033493-kslzdy8q	39	20	coupled	couple	VBN
cord-033493-kslzdy8q	39	21	with	with	IN
cord-033493-kslzdy8q	39	22	malononitrile	malononitrile	NN
cord-033493-kslzdy8q	39	23	or	or	CC
cord-033493-kslzdy8q	39	24	ethyl	ethyl	NN
cord-033493-kslzdy8q	39	25	cyanoacetate	cyanoacetate	NN
cord-033493-kslzdy8q	39	26	in	in	IN
cord-033493-kslzdy8q	39	27	sodium	sodium	NN
cord-033493-kslzdy8q	39	28	acetate	acetate	NN
cord-033493-kslzdy8q	39	29	/	/	SYM
cord-033493-kslzdy8q	39	30	EtOH	EtOH	NNP
cord-033493-kslzdy8q	39	31	to	to	TO
cord-033493-kslzdy8q	39	32	give	give	VB
cord-033493-kslzdy8q	39	33	the	the	DT
cord-033493-kslzdy8q	39	34	corresponding	correspond	VBG
cord-033493-kslzdy8q	39	35	pyrazolotriazines	pyrazolotriazine	NNS
cord-033493-kslzdy8q	39	36	6a	6a	NNP
cord-033493-kslzdy8q	39	37	,	,	,
cord-033493-kslzdy8q	39	38	b	b	LS
cord-033493-kslzdy8q	39	39	(	(	-LRB-
cord-033493-kslzdy8q	39	40	Scheme	scheme	NN
cord-033493-kslzdy8q	39	41	2	2	CD
cord-033493-kslzdy8q	39	42	)	)	-RRB-
cord-033493-kslzdy8q	39	43	.	.	.
cord-033493-kslzdy8q	40	1	The	the	DT
cord-033493-kslzdy8q	40	2	structures	structure	NNS
cord-033493-kslzdy8q	40	3	of	of	IN
cord-033493-kslzdy8q	40	4	the	the	DT
cord-033493-kslzdy8q	40	5	resultant	resultant	JJ
cord-033493-kslzdy8q	40	6	N-(pyrazolo	N-(pyrazolo	NNP
cord-033493-kslzdy8q	40	7	[	[	-LRB-
cord-033493-kslzdy8q	40	8	5,1-c	5,1-c	CD
cord-033493-kslzdy8q	40	9	]	]	-RRB-
cord-033493-kslzdy8q	40	10	[	[	-LRB-
cord-033493-kslzdy8q	40	11	1	1	CD
cord-033493-kslzdy8q	40	12	,	,	,
cord-033493-kslzdy8q	40	13	2	2	CD
cord-033493-kslzdy8q	40	14	,	,	,
cord-033493-kslzdy8q	40	15	4	4	CD
cord-033493-kslzdy8q	40	16	]	]	-RRB-
cord-033493-kslzdy8q	40	17	triazin-7-yl)benzamides	triazin-7-yl)benzamides	NNP
cord-033493-kslzdy8q	40	18	6a	6a	CD
cord-033493-kslzdy8q	40	19	,	,	,
cord-033493-kslzdy8q	40	20	b	b	NNP
cord-033493-kslzdy8q	40	21	were	be	VBD
cord-033493-kslzdy8q	40	22	confirmed	confirm	VBN
cord-033493-kslzdy8q	40	23	according	accord	VBG
cord-033493-kslzdy8q	40	24	to	to	IN
cord-033493-kslzdy8q	40	25	their	-PRON-	PRP$
cord-033493-kslzdy8q	40	26	spectral	spectral	JJ
cord-033493-kslzdy8q	40	27	data	datum	NNS
cord-033493-kslzdy8q	40	28	.	.	.
cord-033493-kslzdy8q	41	1	Thus	thus	RB
cord-033493-kslzdy8q	41	2	,	,	,
cord-033493-kslzdy8q	41	3	the	the	DT
cord-033493-kslzdy8q	41	4	1	1	CD
cord-033493-kslzdy8q	41	5	H	h	NN
cord-033493-kslzdy8q	41	6	NMR	nmr	NN
cord-033493-kslzdy8q	41	7	spectrum	spectrum	NN
cord-033493-kslzdy8q	41	8	for	for	IN
cord-033493-kslzdy8q	41	9	compound	compound	NN
cord-033493-kslzdy8q	41	10	6a	6a	NNP
cord-033493-kslzdy8q	41	11	revealed	reveal	VBD
cord-033493-kslzdy8q	41	12	a	a	DT
cord-033493-kslzdy8q	41	13	multiplet	multiplet	NN
cord-033493-kslzdy8q	41	14	at	at	IN
cord-033493-kslzdy8q	41	15	a	a	DT
cord-033493-kslzdy8q	41	16	range	range	NN
cord-033493-kslzdy8q	41	17	of	of	IN
cord-033493-kslzdy8q	41	18	7.46−8.19	7.46−8.19	CD
cord-033493-kslzdy8q	41	19	ppm	ppm	NN
cord-033493-kslzdy8q	41	20	for	for	IN
cord-033493-kslzdy8q	41	21	the	the	DT
cord-033493-kslzdy8q	41	22	presence	presence	NN
cord-033493-kslzdy8q	41	23	of	of	IN
cord-033493-kslzdy8q	41	24	the	the	DT
cord-033493-kslzdy8q	41	25	phenyl	phenyl	NNP
cord-033493-kslzdy8q	41	26	group	group	NN
cord-033493-kslzdy8q	41	27	,	,	,
cord-033493-kslzdy8q	41	28	a	a	DT
cord-033493-kslzdy8q	41	29	broad	broad	JJ
cord-033493-kslzdy8q	41	30	singlet	singlet	NN
cord-033493-kslzdy8q	41	31	at	at	IN
cord-033493-kslzdy8q	41	32	3.60	3.60	CD
cord-033493-kslzdy8q	41	33	ppm	ppm	NN
cord-033493-kslzdy8q	41	34	for	for	IN
cord-033493-kslzdy8q	41	35	the	the	DT
cord-033493-kslzdy8q	41	36	NH	NH	NNP
cord-033493-kslzdy8q	41	37	2	2	CD
cord-033493-kslzdy8q	41	38	group	group	NN
cord-033493-kslzdy8q	41	39	,	,	,
cord-033493-kslzdy8q	41	40	and	and	CC
cord-033493-kslzdy8q	41	41	a	a	DT
cord-033493-kslzdy8q	41	42	broad	broad	JJ
cord-033493-kslzdy8q	41	43	singlet	singlet	NN
cord-033493-kslzdy8q	41	44	at	at	IN
cord-033493-kslzdy8q	41	45	10.47	10.47	CD
cord-033493-kslzdy8q	41	46	ppm	ppm	NN
cord-033493-kslzdy8q	41	47	for	for	IN
cord-033493-kslzdy8q	41	48	an	an	DT
cord-033493-kslzdy8q	41	49	NH	NH	NNP
cord-033493-kslzdy8q	41	50	group	group	NN
cord-033493-kslzdy8q	41	51	.	.	.
cord-033493-kslzdy8q	42	1	It	-PRON-	PRP
cord-033493-kslzdy8q	42	2	was	be	VBD
cord-033493-kslzdy8q	42	3	found	find	VBN
cord-033493-kslzdy8q	42	4	that	that	IN
cord-033493-kslzdy8q	42	5	the	the	DT
cord-033493-kslzdy8q	42	6	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	42	7	4	4	CD
cord-033493-kslzdy8q	42	8	reacts	react	VBZ
cord-033493-kslzdy8q	42	9	with	with	IN
cord-033493-kslzdy8q	42	10	the	the	DT
cord-033493-kslzdy8q	42	11	sodium	sodium	NN
cord-033493-kslzdy8q	42	12	salts	salt	NNS
cord-033493-kslzdy8q	42	13	of	of	IN
cord-033493-kslzdy8q	42	14	(	(	-LRB-
cord-033493-kslzdy8q	42	15	hydroxymethylene)cycloalkanones	hydroxymethylene)cycloalkanones	NNP
cord-033493-kslzdy8q	42	16	7a	7a	NN
cord-033493-kslzdy8q	42	17	,	,	,
cord-033493-kslzdy8q	42	18	b	b	LS
cord-033493-kslzdy8q	42	19	in	in	IN
cord-033493-kslzdy8q	42	20	the	the	DT
cord-033493-kslzdy8q	42	21	presence	presence	NN
cord-033493-kslzdy8q	42	22	of	of	IN
cord-033493-kslzdy8q	42	23	piperidine	piperidine	NN
cord-033493-kslzdy8q	42	24	acetate−acetic	acetate−acetic	CD
cord-033493-kslzdy8q	42	25	acid	acid	NN
cord-033493-kslzdy8q	42	26	to	to	TO
cord-033493-kslzdy8q	42	27	give	give	VB
cord-033493-kslzdy8q	42	28	an	an	DT
cord-033493-kslzdy8q	42	29	adduct	adduct	NN
cord-033493-kslzdy8q	42	30	,	,	,
cord-033493-kslzdy8q	42	31	where	where	WRB
cord-033493-kslzdy8q	42	32	the	the	DT
cord-033493-kslzdy8q	42	33	structure	structure	NN
cord-033493-kslzdy8q	42	34	of	of	IN
cord-033493-kslzdy8q	42	35	8a	8a	NN
cord-033493-kslzdy8q	42	36	,	,	,
cord-033493-kslzdy8q	42	37	b	b	NNP
cord-033493-kslzdy8q	42	38	was	be	VBD
cord-033493-kslzdy8q	42	39	established	establish	VBN
cord-033493-kslzdy8q	42	40	.	.	.
cord-033493-kslzdy8q	43	1	The	the	DT
cord-033493-kslzdy8q	43	2	reaction	reaction	NN
cord-033493-kslzdy8q	43	3	begins	begin	VBZ
cord-033493-kslzdy8q	43	4	with	with	IN
cord-033493-kslzdy8q	43	5	an	an	DT
cord-033493-kslzdy8q	43	6	initial	initial	JJ
cord-033493-kslzdy8q	43	7	nucleophilic	nucleophilic	JJ
cord-033493-kslzdy8q	43	8	attack	attack	NN
cord-033493-kslzdy8q	43	9	from	from	IN
cord-033493-kslzdy8q	43	10	the	the	DT
cord-033493-kslzdy8q	43	11	external	external	JJ
cord-033493-kslzdy8q	43	12	amino	amino	NN
cord-033493-kslzdy8q	43	13	group	group	NN
cord-033493-kslzdy8q	43	14	to	to	IN
cord-033493-kslzdy8q	43	15	the	the	DT
cord-033493-kslzdy8q	43	16	formyl	formyl	NNP
cord-033493-kslzdy8q	43	17	group	group	NN
cord-033493-kslzdy8q	43	18	followed	follow	VBN
cord-033493-kslzdy8q	43	19	by	by	IN
cord-033493-kslzdy8q	43	20	cyclization	cyclization	NN
cord-033493-kslzdy8q	43	21	and	and	CC
cord-033493-kslzdy8q	43	22	then	then	RB
cord-033493-kslzdy8q	43	23	removal	removal	NN
cord-033493-kslzdy8q	43	24	of	of	IN
cord-033493-kslzdy8q	43	25	one	one	CD
cord-033493-kslzdy8q	43	26	molecule	molecule	NN
cord-033493-kslzdy8q	43	27	of	of	IN
cord-033493-kslzdy8q	43	28	water	water	NN
cord-033493-kslzdy8q	43	29	to	to	TO
cord-033493-kslzdy8q	43	30	produce	produce	VB
cord-033493-kslzdy8q	43	31	the	the	DT
cord-033493-kslzdy8q	43	32	angular	angular	JJ
cord-033493-kslzdy8q	43	33	tricyclic	tricyclic	NN
cord-033493-kslzdy8q	43	34	compounds	compound	NNS
cord-033493-kslzdy8q	43	35	8a	8a	NNP
cord-033493-kslzdy8q	43	36	,	,	,
cord-033493-kslzdy8q	43	37	b	b	NNP
cord-033493-kslzdy8q	43	38	.	.	.
cord-033493-kslzdy8q	44	1	In	in	IN
cord-033493-kslzdy8q	44	2	the	the	DT
cord-033493-kslzdy8q	44	3	presence	presence	NN
cord-033493-kslzdy8q	44	4	of	of	IN
cord-033493-kslzdy8q	44	5	an	an	DT
cord-033493-kslzdy8q	44	6	acid	acid	NN
cord-033493-kslzdy8q	44	7	medium	medium	NN
cord-033493-kslzdy8q	44	8	,	,	,
cord-033493-kslzdy8q	44	9	first	first	RB
cord-033493-kslzdy8q	44	10	,	,	,
cord-033493-kslzdy8q	44	11	the	the	DT
cord-033493-kslzdy8q	44	12	protonation	protonation	NN
cord-033493-kslzdy8q	44	13	of	of	IN
cord-033493-kslzdy8q	44	14	the	the	DT
cord-033493-kslzdy8q	44	15	ring	ring	NN
cord-033493-kslzdy8q	44	16	nitrogen	nitrogen	NN
cord-033493-kslzdy8q	44	17	occurs	occur	VBZ
cord-033493-kslzdy8q	44	18	,	,	,
cord-033493-kslzdy8q	44	19	which	which	WDT
cord-033493-kslzdy8q	44	20	is	be	VBZ
cord-033493-kslzdy8q	44	21	the	the	DT
cord-033493-kslzdy8q	44	22	most	most	RBS
cord-033493-kslzdy8q	44	23	nucleophilic	nucleophilic	JJ
cord-033493-kslzdy8q	44	24	center	center	NN
cord-033493-kslzdy8q	44	25	38−43	38−43	CD
cord-033493-kslzdy8q	44	26	in	in	IN
cord-033493-kslzdy8q	44	27	compound	compound	NN
cord-033493-kslzdy8q	44	28	4	4	CD
cord-033493-kslzdy8q	44	29	,	,	,
cord-033493-kslzdy8q	44	30	which	which	WDT
cord-033493-kslzdy8q	44	31	directs	direct	VBZ
cord-033493-kslzdy8q	44	32	the	the	DT
cord-033493-kslzdy8q	44	33	exocyclic	exocyclic	NNP
cord-033493-kslzdy8q	44	34	amino	amino	NNP
cord-033493-kslzdy8q	44	35	group	group	NN
cord-033493-kslzdy8q	44	36	to	to	TO
cord-033493-kslzdy8q	44	37	attack	attack	VB
cord-033493-kslzdy8q	44	38	the	the	DT
cord-033493-kslzdy8q	44	39	unhindered	unhindered	JJ
cord-033493-kslzdy8q	44	40	formyl	formyl	NNP
cord-033493-kslzdy8q	44	41	group	group	NNP
cord-033493-kslzdy8q	44	42	of	of	IN
cord-033493-kslzdy8q	44	43	7	7	CD
cord-033493-kslzdy8q	44	44	to	to	TO
cord-033493-kslzdy8q	44	45	yield	yield	VB
cord-033493-kslzdy8q	44	46	compounds	compound	NNS
cord-033493-kslzdy8q	44	47	8a	8a	NN
cord-033493-kslzdy8q	44	48	,	,	,
cord-033493-kslzdy8q	44	49	b	b	LS
cord-033493-kslzdy8q	44	50	(	(	-LRB-
cord-033493-kslzdy8q	44	51	Scheme	scheme	NN
cord-033493-kslzdy8q	44	52	3	3	CD
cord-033493-kslzdy8q	44	53	)	)	-RRB-
cord-033493-kslzdy8q	44	54	.	.	.
cord-033493-kslzdy8q	45	1	The	the	DT
cord-033493-kslzdy8q	45	2	1	1	CD
cord-033493-kslzdy8q	45	3	H	h	NN
cord-033493-kslzdy8q	45	4	NMR	nmr	NN
cord-033493-kslzdy8q	45	5	spectrum	spectrum	NN
cord-033493-kslzdy8q	45	6	of	of	IN
cord-033493-kslzdy8q	45	7	8a	8a	NNP
cord-033493-kslzdy8q	45	8	showed	show	VBD
cord-033493-kslzdy8q	45	9	the	the	DT
cord-033493-kslzdy8q	45	10	existence	existence	NN
cord-033493-kslzdy8q	45	11	of	of	IN
cord-033493-kslzdy8q	45	12	a	a	DT
cord-033493-kslzdy8q	45	13	signal	signal	NN
cord-033493-kslzdy8q	45	14	at	at	IN
cord-033493-kslzdy8q	45	15	δ	δ	NN
cord-033493-kslzdy8q	45	16	8.80	8.80	CD
cord-033493-kslzdy8q	45	17	ppm	ppm	NN
cord-033493-kslzdy8q	45	18	assigned	assign	VBN
cord-033493-kslzdy8q	45	19	to	to	IN
cord-033493-kslzdy8q	45	20	a	a	DT
cord-033493-kslzdy8q	45	21	pyrimidine	pyrimidine	NN
cord-033493-kslzdy8q	45	22	-	-	HYPH
cord-033493-kslzdy8q	45	23	H	h	NN
cord-033493-kslzdy8q	45	24	proton	proton	NN
cord-033493-kslzdy8q	45	25	.	.	.
cord-033493-kslzdy8q	46	1	The	the	DT
cord-033493-kslzdy8q	46	2	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	46	3	4	4	CD
cord-033493-kslzdy8q	46	4	reacted	react	VBD
cord-033493-kslzdy8q	46	5	with	with	IN
cord-033493-kslzdy8q	46	6	arylmethylene	arylmethylene	JJ
cord-033493-kslzdy8q	46	7	malononitriles	malononitrile	NNS
cord-033493-kslzdy8q	46	8	9	9	CD
cord-033493-kslzdy8q	46	9	with	with	IN
cord-033493-kslzdy8q	46	10	piperidine	piperidine	NN
cord-033493-kslzdy8q	46	11	as	as	IN
cord-033493-kslzdy8q	46	12	a	a	DT
cord-033493-kslzdy8q	46	13	catalyst	catalyst	NN
cord-033493-kslzdy8q	46	14	to	to	TO
cord-033493-kslzdy8q	46	15	give	give	VB
cord-033493-kslzdy8q	46	16	the	the	DT
cord-033493-kslzdy8q	46	17	pyrazolo[1,5-a]pyrimidines	pyrazolo[1,5-a]pyrimidines	NNPS
cord-033493-kslzdy8q	46	18	10a−c	10a−c	CD
cord-033493-kslzdy8q	46	19	.	.	.
cord-033493-kslzdy8q	47	1	The	the	DT
cord-033493-kslzdy8q	47	2	reaction	reaction	NN
cord-033493-kslzdy8q	47	3	proceeded	proceed	VBD
cord-033493-kslzdy8q	47	4	by	by	IN
cord-033493-kslzdy8q	47	5	Michael	Michael	NNP
cord-033493-kslzdy8q	47	6	addition	addition	NN
cord-033493-kslzdy8q	47	7	of	of	IN
cord-033493-kslzdy8q	47	8	the	the	DT
cord-033493-kslzdy8q	47	9	exocyclic	exocyclic	NNP
cord-033493-kslzdy8q	47	10	amino	amino	NNP
cord-033493-kslzdy8q	47	11	group	group	NN
cord-033493-kslzdy8q	47	12	of	of	IN
cord-033493-kslzdy8q	47	13	4	4	CD
cord-033493-kslzdy8q	47	14	to	to	IN
cord-033493-kslzdy8q	47	15	the	the	DT
cord-033493-kslzdy8q	47	16	double	double	JJ
cord-033493-kslzdy8q	47	17	bond	bond	NN
cord-033493-kslzdy8q	47	18	of	of	IN
cord-033493-kslzdy8q	47	19	9	9	CD
cord-033493-kslzdy8q	47	20	followed	follow	VBN
cord-033493-kslzdy8q	47	21	by	by	IN
cord-033493-kslzdy8q	47	22	cyclization	cyclization	NN
cord-033493-kslzdy8q	47	23	through	through	IN
cord-033493-kslzdy8q	47	24	the	the	DT
cord-033493-kslzdy8q	47	25	addition	addition	NN
cord-033493-kslzdy8q	47	26	of	of	IN
cord-033493-kslzdy8q	47	27	the	the	DT
cord-033493-kslzdy8q	47	28	ring	ring	NN
cord-033493-kslzdy8q	47	29	NH	NH	NNP
cord-033493-kslzdy8q	47	30	to	to	IN
cord-033493-kslzdy8q	47	31	the	the	DT
cord-033493-kslzdy8q	47	32	cyano	cyano	NNP
cord-033493-kslzdy8q	47	33	group	group	NN
cord-033493-kslzdy8q	47	34	to	to	TO
cord-033493-kslzdy8q	47	35	give	give	VB
cord-033493-kslzdy8q	47	36	the	the	DT
cord-033493-kslzdy8q	47	37	pyrazolo[1,5a]pyrimidines	pyrazolo[1,5a]pyrimidine	NNS
cord-033493-kslzdy8q	47	38	10	10	CD
cord-033493-kslzdy8q	47	39	(	(	-LRB-
cord-033493-kslzdy8q	47	40	Scheme	scheme	NN
cord-033493-kslzdy8q	47	41	3	3	CD
cord-033493-kslzdy8q	47	42	)	)	-RRB-
cord-033493-kslzdy8q	47	43	.	.	.
cord-033493-kslzdy8q	48	1	The	the	DT
cord-033493-kslzdy8q	48	2	structures	structure	NNS
cord-033493-kslzdy8q	48	3	of	of	IN
cord-033493-kslzdy8q	48	4	10a−c	10a−c	NNS
cord-033493-kslzdy8q	48	5	were	be	VBD
cord-033493-kslzdy8q	48	6	confirmed	confirm	VBN
cord-033493-kslzdy8q	48	7	by	by	IN
cord-033493-kslzdy8q	48	8	1	1	CD
cord-033493-kslzdy8q	48	9	H	h	NN
cord-033493-kslzdy8q	48	10	NMR	nmr	NN
cord-033493-kslzdy8q	48	11	,	,	,
cord-033493-kslzdy8q	48	12	which	which	WDT
cord-033493-kslzdy8q	48	13	revealed	reveal	VBD
cord-033493-kslzdy8q	48	14	for	for	IN
cord-033493-kslzdy8q	48	15	compound	compound	NN
cord-033493-kslzdy8q	48	16	10b	10b	NNS
cord-033493-kslzdy8q	48	17	a	a	DT
cord-033493-kslzdy8q	48	18	singlet	singlet	NN
cord-033493-kslzdy8q	48	19	at	at	IN
cord-033493-kslzdy8q	48	20	3.88	3.88	CD
cord-033493-kslzdy8q	48	21	ppm	ppm	NN
cord-033493-kslzdy8q	48	22	assigned	assign	VBN
cord-033493-kslzdy8q	48	23	to	to	IN
cord-033493-kslzdy8q	48	24	the	the	DT
cord-033493-kslzdy8q	48	25	OCH	OCH	NNP
cord-033493-kslzdy8q	48	26	3	3	CD
cord-033493-kslzdy8q	48	27	group	group	NN
cord-033493-kslzdy8q	48	28	,	,	,
cord-033493-kslzdy8q	48	29	a	a	DT
cord-033493-kslzdy8q	48	30	singlet	singlet	NN
cord-033493-kslzdy8q	48	31	at	at	IN
cord-033493-kslzdy8q	48	32	9.18	9.18	CD
cord-033493-kslzdy8q	48	33	ppm	ppm	NN
cord-033493-kslzdy8q	48	34	assigned	assign	VBN
cord-033493-kslzdy8q	48	35	to	to	IN
cord-033493-kslzdy8q	48	36	the	the	DT
cord-033493-kslzdy8q	48	37	NH	NH	NNP
cord-033493-kslzdy8q	48	38	2	2	CD
cord-033493-kslzdy8q	48	39	group	group	NN
cord-033493-kslzdy8q	48	40	,	,	,
cord-033493-kslzdy8q	48	41	a	a	DT
cord-033493-kslzdy8q	48	42	multiplet	multiplet	NN
cord-033493-kslzdy8q	48	43	at	at	IN
cord-033493-kslzdy8q	48	44	a	a	DT
cord-033493-kslzdy8q	48	45	range	range	NN
cord-033493-kslzdy8q	48	46	of	of	IN
cord-033493-kslzdy8q	48	47	7.15−8.23	7.15−8.23	CD
cord-033493-kslzdy8q	48	48	ppm	ppm	NN
cord-033493-kslzdy8q	48	49	for	for	IN
cord-033493-kslzdy8q	48	50	aromatic	aromatic	JJ
cord-033493-kslzdy8q	48	51	protons	proton	NNS
cord-033493-kslzdy8q	48	52	,	,	,
cord-033493-kslzdy8q	48	53	and	and	CC
cord-033493-kslzdy8q	48	54	a	a	DT
cord-033493-kslzdy8q	48	55	broad	broad	JJ
cord-033493-kslzdy8q	48	56	singlet	singlet	NN
cord-033493-kslzdy8q	48	57	at	at	IN
cord-033493-kslzdy8q	48	58	12.19	12.19	CD
cord-033493-kslzdy8q	48	59	ppm	ppm	NN
cord-033493-kslzdy8q	48	60	to	to	TO
cord-033493-kslzdy8q	48	61	indicate	indicate	VB
cord-033493-kslzdy8q	48	62	the	the	DT
cord-033493-kslzdy8q	48	63	presence	presence	NN
cord-033493-kslzdy8q	48	64	of	of	IN
cord-033493-kslzdy8q	48	65	the	the	DT
cord-033493-kslzdy8q	48	66	NH	NH	NNP
cord-033493-kslzdy8q	48	67	group	group	NN
cord-033493-kslzdy8q	48	68	.	.	.
cord-033493-kslzdy8q	49	1	The	the	DT
cord-033493-kslzdy8q	49	2	reactivity	reactivity	NN
cord-033493-kslzdy8q	49	3	of	of	IN
cord-033493-kslzdy8q	49	4	diketones	diketone	NNS
cord-033493-kslzdy8q	49	5	and	and	CC
cord-033493-kslzdy8q	49	6	keto	keto	NNP
cord-033493-kslzdy8q	49	7	esters	ester	NNS
cord-033493-kslzdy8q	49	8	such	such	JJ
cord-033493-kslzdy8q	49	9	as	as	IN
cord-033493-kslzdy8q	49	10	acetyl	acetyl	NN
cord-033493-kslzdy8q	49	11	acetone	acetone	NN
cord-033493-kslzdy8q	49	12	11a	11a	NNS
cord-033493-kslzdy8q	49	13	and	and	CC
cord-033493-kslzdy8q	49	14	ethyl	ethyl	NN
cord-033493-kslzdy8q	49	15	acetoacetate	acetoacetate	NN
cord-033493-kslzdy8q	49	16	11b	11b	NNS
cord-033493-kslzdy8q	50	1	with	with	IN
cord-033493-kslzdy8q	50	2	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	50	3	4	4	CD
cord-033493-kslzdy8q	50	4	was	be	VBD
cord-033493-kslzdy8q	50	5	studied	study	VBN
cord-033493-kslzdy8q	50	6	through	through	IN
cord-033493-kslzdy8q	50	7	a	a	DT
cord-033493-kslzdy8q	50	8	reaction	reaction	NN
cord-033493-kslzdy8q	50	9	with	with	IN
cord-033493-kslzdy8q	50	10	piperidine	piperidine	NN
cord-033493-kslzdy8q	50	11	and	and	CC
cord-033493-kslzdy8q	50	12	boiling	boil	VBG
cord-033493-kslzdy8q	50	13	ethanol	ethanol	NN
cord-033493-kslzdy8q	50	14	to	to	TO
cord-033493-kslzdy8q	50	15	afford	afford	VB
cord-033493-kslzdy8q	50	16	the	the	DT
cord-033493-kslzdy8q	50	17	corresponding	correspond	VBG
cord-033493-kslzdy8q	50	18	pyrazolo[1,5-a]pyrimidines	pyrazolo[1,5-a]pyrimidines	NNPS
cord-033493-kslzdy8q	50	19	12a	12a	NNS
cord-033493-kslzdy8q	50	20	,	,	,
cord-033493-kslzdy8q	50	21	b	b	NN
cord-033493-kslzdy8q	50	22	.	.	.
cord-033493-kslzdy8q	51	1	An	an	DT
cord-033493-kslzdy8q	51	2	attempt	attempt	NN
cord-033493-kslzdy8q	51	3	to	to	TO
cord-033493-kslzdy8q	51	4	react	react	VB
cord-033493-kslzdy8q	51	5	benzoyl	benzoyl	NN
cord-033493-kslzdy8q	51	6	isothiocyanate	isothiocyanate	NN
cord-033493-kslzdy8q	51	7	with	with	IN
cord-033493-kslzdy8q	51	8	ethyl	ethyl	NN
cord-033493-kslzdy8q	51	9	cyanoacetate	cyanoacetate	NN
cord-033493-kslzdy8q	51	10	in	in	IN
cord-033493-kslzdy8q	51	11	KOH−EtOH	KOH−EtOH	NNP
cord-033493-kslzdy8q	51	12	with	with	IN
cord-033493-kslzdy8q	51	13	heating	heating	NN
cord-033493-kslzdy8q	51	14	followed	follow	VBN
cord-033493-kslzdy8q	51	15	by	by	IN
cord-033493-kslzdy8q	51	16	alkylation	alkylation	NN
cord-033493-kslzdy8q	51	17	with	with	IN
cord-033493-kslzdy8q	51	18	methyl	methyl	NN
cord-033493-kslzdy8q	51	19	iodides	iodide	NNS
cord-033493-kslzdy8q	51	20	at	at	IN
cord-033493-kslzdy8q	51	21	room	room	NN
cord-033493-kslzdy8q	51	22	temperature	temperature	NN
cord-033493-kslzdy8q	51	23	has	have	VBZ
cord-033493-kslzdy8q	51	24	resulted	result	VBN
cord-033493-kslzdy8q	51	25	in	in	IN
cord-033493-kslzdy8q	51	26	the	the	DT
cord-033493-kslzdy8q	51	27	formation	formation	NN
cord-033493-kslzdy8q	51	28	of	of	IN
cord-033493-kslzdy8q	51	29	the	the	DT
cord-033493-kslzdy8q	51	30	corresponding	correspond	VBG
cord-033493-kslzdy8q	51	31	(	(	-LRB-
cord-033493-kslzdy8q	51	32	E)-ethyl	E)-ethyl	NNP
cord-033493-kslzdy8q	51	33	3benzamido-2-cyano-3-(methylthio)acrylate	3benzamido-2-cyano-3-(methylthio)acrylate	CD
cord-033493-kslzdy8q	51	34	14	14	CD
cord-033493-kslzdy8q	51	35	.	.	.
cord-033493-kslzdy8q	52	1	The	the	DT
cord-033493-kslzdy8q	52	2	reaction	reaction	NN
cord-033493-kslzdy8q	52	3	of	of	IN
cord-033493-kslzdy8q	52	4	(	(	-LRB-
cord-033493-kslzdy8q	52	5	E)-ethyl	E)-ethyl	NNP
cord-033493-kslzdy8q	52	6	3-benzamido-2-cyano-3-(methylthio)acrylate	3-benzamido-2-cyano-3-(methylthio)acrylate	CD
cord-033493-kslzdy8q	52	7	14	14	CD
cord-033493-kslzdy8q	52	8	with	with	IN
cord-033493-kslzdy8q	52	9	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	52	10	was	be	VBD
cord-033493-kslzdy8q	52	11	investigated	investigate	VBN
cord-033493-kslzdy8q	52	12	.	.	.
cord-033493-kslzdy8q	53	1	The	the	DT
cord-033493-kslzdy8q	53	2	reaction	reaction	NN
cord-033493-kslzdy8q	53	3	between	between	IN
cord-033493-kslzdy8q	53	4	14	14	CD
cord-033493-kslzdy8q	53	5	and	and	CC
cord-033493-kslzdy8q	53	6	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	53	7	gave	give	VBD
cord-033493-kslzdy8q	53	8	a	a	DT
cord-033493-kslzdy8q	53	9	product	product	NN
cord-033493-kslzdy8q	53	10	whose	whose	WP$
cord-033493-kslzdy8q	53	11	mass	mass	NN
cord-033493-kslzdy8q	53	12	spectra	spectrum	NNS
cord-033493-kslzdy8q	53	13	were	be	VBD
cord-033493-kslzdy8q	53	14	not	not	RB
cord-033493-kslzdy8q	53	15	consistent	consistent	JJ
cord-033493-kslzdy8q	53	16	with	with	IN
cord-033493-kslzdy8q	53	17	the	the	DT
cord-033493-kslzdy8q	53	18	proposed	propose	VBN
cord-033493-kslzdy8q	53	19	pyrazole	pyrazole	NN
cord-033493-kslzdy8q	53	20	structure	structure	NN
cord-033493-kslzdy8q	53	21	16	16	CD
cord-033493-kslzdy8q	53	22	,	,	,
cord-033493-kslzdy8q	53	23	and	and	CC
cord-033493-kslzdy8q	53	24	other	other	JJ
cord-033493-kslzdy8q	53	25	spectroscopic	spectroscopic	JJ
cord-033493-kslzdy8q	53	26	measurements	measurement	NNS
cord-033493-kslzdy8q	53	27	did	do	VBD
cord-033493-kslzdy8q	53	28	not	not	RB
cord-033493-kslzdy8q	53	29	allow	allow	VB
cord-033493-kslzdy8q	53	30	us	-PRON-	PRP
cord-033493-kslzdy8q	53	31	to	to	TO
cord-033493-kslzdy8q	53	32	unambiguously	unambiguously	RB
cord-033493-kslzdy8q	53	33	identify	identify	VB
cord-033493-kslzdy8q	53	34	the	the	DT
cord-033493-kslzdy8q	53	35	product	product	NN
cord-033493-kslzdy8q	53	36	,	,	,
cord-033493-kslzdy8q	53	37	and	and	CC
cord-033493-kslzdy8q	53	38	thus	thus	RB
cord-033493-kslzdy8q	53	39	,	,	,
cord-033493-kslzdy8q	53	40	the	the	DT
cord-033493-kslzdy8q	53	41	X	x	NN
cord-033493-kslzdy8q	53	42	-	-	NN
cord-033493-kslzdy8q	53	43	ray	ray	NNP
cord-033493-kslzdy8q	53	44	crystal	crystal	NN
cord-033493-kslzdy8q	53	45	structure	structure	NN
cord-033493-kslzdy8q	53	46	was	be	VBD
cord-033493-kslzdy8q	53	47	determined	determine	VBN
cord-033493-kslzdy8q	53	48	as	as	IN
cord-033493-kslzdy8q	53	49	shown	show	VBN
cord-033493-kslzdy8q	53	50	in	in	IN
cord-033493-kslzdy8q	53	51	Figure	Figure	NNP
cord-033493-kslzdy8q	53	52	3	3	CD
cord-033493-kslzdy8q	53	53	,	,	,
cord-033493-kslzdy8q	53	54	44	44	CD
cord-033493-kslzdy8q	53	55	confirming	confirm	VBG
cord-033493-kslzdy8q	53	56	the	the	DT
cord-033493-kslzdy8q	53	57	exclusive	exclusive	JJ
cord-033493-kslzdy8q	53	58	presence	presence	NN
cord-033493-kslzdy8q	53	59	of	of	IN
cord-033493-kslzdy8q	53	60	the	the	DT
cord-033493-kslzdy8q	53	61	triazole	triazole	NNP
cord-033493-kslzdy8q	53	62	derivative	derivative	NNP
cord-033493-kslzdy8q	53	63	19	19	CD
cord-033493-kslzdy8q	53	64	as	as	IN
cord-033493-kslzdy8q	53	65	the	the	DT
cord-033493-kslzdy8q	53	66	sole	sole	JJ
cord-033493-kslzdy8q	53	67	product	product	NN
cord-033493-kslzdy8q	53	68	in	in	IN
cord-033493-kslzdy8q	53	69	the	the	DT
cord-033493-kslzdy8q	53	70	solid	solid	JJ
cord-033493-kslzdy8q	53	71	state	state	NN
cord-033493-kslzdy8q	53	72	.	.	.
cord-033493-kslzdy8q	54	1	The	the	DT
cord-033493-kslzdy8q	54	2	formation	formation	NN
cord-033493-kslzdy8q	54	3	of	of	IN
cord-033493-kslzdy8q	54	4	19	19	CD
cord-033493-kslzdy8q	54	5	from	from	IN
cord-033493-kslzdy8q	54	6	the	the	DT
cord-033493-kslzdy8q	54	7	reaction	reaction	NN
cord-033493-kslzdy8q	54	8	of	of	IN
cord-033493-kslzdy8q	54	9	14	14	CD
cord-033493-kslzdy8q	54	10	and	and	CC
cord-033493-kslzdy8q	54	11	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	54	12	is	be	VBZ
cord-033493-kslzdy8q	54	13	suggested	suggest	VBN
cord-033493-kslzdy8q	54	14	to	to	TO
cord-033493-kslzdy8q	54	15	proceed	proceed	VB
cord-033493-kslzdy8q	54	16	via	via	IN
cord-033493-kslzdy8q	54	17	initial	initial	JJ
cord-033493-kslzdy8q	54	18	addition	addition	NN
cord-033493-kslzdy8q	54	19	of	of	IN
cord-033493-kslzdy8q	54	20	basic	basic	JJ
cord-033493-kslzdy8q	54	21	nitrogen	nitrogen	NN
cord-033493-kslzdy8q	54	22	in	in	IN
cord-033493-kslzdy8q	54	23	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	54	24	to	to	IN
cord-033493-kslzdy8q	54	25	the	the	DT
cord-033493-kslzdy8q	54	26	double	double	JJ
cord-033493-kslzdy8q	54	27	bond	bond	NN
cord-033493-kslzdy8q	54	28	of	of	IN
cord-033493-kslzdy8q	54	29	14	14	CD
cord-033493-kslzdy8q	54	30	followed	follow	VBN
cord-033493-kslzdy8q	54	31	by	by	IN
cord-033493-kslzdy8q	54	32	the	the	DT
cord-033493-kslzdy8q	54	33	formation	formation	NN
cord-033493-kslzdy8q	54	34	of	of	IN
cord-033493-kslzdy8q	54	35	the	the	DT
cord-033493-kslzdy8q	54	36	adduct	adduct	NN
cord-033493-kslzdy8q	54	37	15	15	CD
cord-033493-kslzdy8q	54	38	and	and	CC
cord-033493-kslzdy8q	54	39	elimination	elimination	NN
cord-033493-kslzdy8q	54	40	of	of	IN
cord-033493-kslzdy8q	54	41	ethyl	ethyl	NN
cord-033493-kslzdy8q	54	42	cyanoacetate	cyanoacetate	NN
cord-033493-kslzdy8q	54	43	.	.	.
cord-033493-kslzdy8q	55	1	The	the	DT
cord-033493-kslzdy8q	55	2	adduct	adduct	NN
cord-033493-kslzdy8q	55	3	15	15	CD
cord-033493-kslzdy8q	55	4	leads	lead	VBZ
cord-033493-kslzdy8q	55	5	to	to	IN
cord-033493-kslzdy8q	55	6	the	the	DT
cord-033493-kslzdy8q	55	7	formation	formation	NN
cord-033493-kslzdy8q	55	8	of	of	IN
cord-033493-kslzdy8q	55	9	the	the	DT
cord-033493-kslzdy8q	55	10	favored	favor	VBN
cord-033493-kslzdy8q	55	11	,	,	,
cord-033493-kslzdy8q	55	12	kinetically	kinetically	RB
cord-033493-kslzdy8q	55	13	and	and	CC
cord-033493-kslzdy8q	55	14	thermodynamically	thermodynamically	RB
cord-033493-kslzdy8q	55	15	controlled	control	VBN
cord-033493-kslzdy8q	55	16	3ethoxy-5-phenyl-1H-1,2,4-triazole	3ethoxy-5-phenyl-1h-1,2,4-triazole	NN
cord-033493-kslzdy8q	55	17	product	product	NN
cord-033493-kslzdy8q	55	18	19	19	CD
cord-033493-kslzdy8q	55	19	(	(	-LRB-
cord-033493-kslzdy8q	55	20	Scheme	scheme	NN
cord-033493-kslzdy8q	55	21	4	4	CD
cord-033493-kslzdy8q	55	22	)	)	-RRB-
cord-033493-kslzdy8q	55	23	.	.	.
cord-033493-kslzdy8q	56	1	The	the	DT
cord-033493-kslzdy8q	56	2	1	1	CD
cord-033493-kslzdy8q	56	3	H	h	NN
cord-033493-kslzdy8q	56	4	NMR	nmr	NN
cord-033493-kslzdy8q	56	5	spectra	spectra	NN
cord-033493-kslzdy8q	56	6	of	of	IN
cord-033493-kslzdy8q	56	7	the	the	DT
cord-033493-kslzdy8q	56	8	product	product	NN
cord-033493-kslzdy8q	56	9	19	19	CD
cord-033493-kslzdy8q	56	10	revealed	reveal	VBD
cord-033493-kslzdy8q	56	11	the	the	DT
cord-033493-kslzdy8q	56	12	presence	presence	NN
cord-033493-kslzdy8q	56	13	of	of	IN
cord-033493-kslzdy8q	56	14	an	an	DT
cord-033493-kslzdy8q	56	15	ethoxy	ethoxy	JJ
cord-033493-kslzdy8q	56	16	group	group	NN
cord-033493-kslzdy8q	56	17	as	as	IN
cord-033493-kslzdy8q	56	18	a	a	DT
cord-033493-kslzdy8q	56	19	broad	broad	JJ
cord-033493-kslzdy8q	56	20	singlet	singlet	NN
cord-033493-kslzdy8q	56	21	at	at	IN
cord-033493-kslzdy8q	56	22	δ1.37	δ1.37	CD
cord-033493-kslzdy8q	56	23	ppm	ppm	NN
cord-033493-kslzdy8q	56	24	assigned	assign	VBN
cord-033493-kslzdy8q	56	25	to	to	IN
cord-033493-kslzdy8q	56	26	the	the	DT
cord-033493-kslzdy8q	56	27	CH	CH	NNP
cord-033493-kslzdy8q	56	28	3	3	CD
cord-033493-kslzdy8q	56	29	group	group	NN
cord-033493-kslzdy8q	56	30	and	and	CC
cord-033493-kslzdy8q	56	31	a	a	DT
cord-033493-kslzdy8q	56	32	broad	broad	JJ
cord-033493-kslzdy8q	56	33	singlet	singlet	NN
cord-033493-kslzdy8q	56	34	at	at	IN
cord-033493-kslzdy8q	56	35	δ	δ	NN
cord-033493-kslzdy8q	56	36	4.34	4.34	CD
cord-033493-kslzdy8q	56	37	ppm	ppm	NN
cord-033493-kslzdy8q	56	38	assigned	assign	VBN
cord-033493-kslzdy8q	56	39	to	to	IN
cord-033493-kslzdy8q	56	40	the	the	DT
cord-033493-kslzdy8q	56	41	CH	CH	NNP
cord-033493-kslzdy8q	56	42	2	2	CD
cord-033493-kslzdy8q	56	43	group	group	NN
cord-033493-kslzdy8q	56	44	,	,	,
cord-033493-kslzdy8q	56	45	a	a	DT
cord-033493-kslzdy8q	56	46	multiplet	multiplet	NN
cord-033493-kslzdy8q	56	47	at	at	IN
cord-033493-kslzdy8q	56	48	δ	δ	NN
cord-033493-kslzdy8q	56	49	7.47−7.93	7.47−7.93	CD
cord-033493-kslzdy8q	56	50	ppm	ppm	NN
cord-033493-kslzdy8q	56	51	assigned	assign	VBN
cord-033493-kslzdy8q	56	52	to	to	IN
cord-033493-kslzdy8q	56	53	the	the	DT
cord-033493-kslzdy8q	56	54	phenyl	phenyl	NNP
cord-033493-kslzdy8q	56	55	group	group	NN
cord-033493-kslzdy8q	56	56	,	,	,
cord-033493-kslzdy8q	56	57	and	and	CC
cord-033493-kslzdy8q	56	58	a	a	DT
cord-033493-kslzdy8q	56	59	triazole	triazole	NN
cord-033493-kslzdy8q	56	60	ring	ring	NNP
cord-033493-kslzdy8q	56	61	NH	NH	NNP
cord-033493-kslzdy8q	56	62	at	at	IN
cord-033493-kslzdy8q	56	63	δ	δ	NN
cord-033493-kslzdy8q	56	64	13.72	13.72	CD
cord-033493-kslzdy8q	56	65	ppm	ppm	NN
cord-033493-kslzdy8q	56	66	.	.	.
cord-033493-kslzdy8q	57	1	The	the	DT
cord-033493-kslzdy8q	57	2	potassium	potassium	NN
cord-033493-kslzdy8q	57	3	ethylenethiolate	ethylenethiolate	NN
cord-033493-kslzdy8q	57	4	salts	salt	NNS
cord-033493-kslzdy8q	57	5	2	2	CD
cord-033493-kslzdy8q	57	6	and	and	CC
cord-033493-kslzdy8q	57	7	13	13	CD
cord-033493-kslzdy8q	57	8	reacted	react	VBD
cord-033493-kslzdy8q	57	9	with	with	IN
cord-033493-kslzdy8q	57	10	tetra	tetra	NN
cord-033493-kslzdy8q	57	11	-	-	HYPH
cord-033493-kslzdy8q	57	12	O	o	NN
cord-033493-kslzdy8q	57	13	-	-	HYPH
cord-033493-kslzdy8q	57	14	acetyl	acetyl	NN
cord-033493-kslzdy8q	57	15	-	-	HYPH
cord-033493-kslzdy8q	57	16	glucopyranosyl	glucopyranosyl	NN
cord-033493-kslzdy8q	57	17	bromide	bromide	NN
cord-033493-kslzdy8q	57	18	20	20	CD
cord-033493-kslzdy8q	57	19	at	at	IN
cord-033493-kslzdy8q	57	20	room	room	NN
cord-033493-kslzdy8q	57	21	temperature	temperature	NN
cord-033493-kslzdy8q	57	22	and	and	CC
cord-033493-kslzdy8q	57	23	in	in	IN
cord-033493-kslzdy8q	57	24	ethanol	ethanol	NN
cord-033493-kslzdy8q	57	25	to	to	TO
cord-033493-kslzdy8q	57	26	give	give	VB
cord-033493-kslzdy8q	57	27	with	with	IN
cord-033493-kslzdy8q	57	28	a	a	DT
cord-033493-kslzdy8q	57	29	high	high	JJ
cord-033493-kslzdy8q	57	30	yield	yield	NN
cord-033493-kslzdy8q	57	31	the	the	DT
cord-033493-kslzdy8q	57	32	corresponding	correspond	VBG
cord-033493-kslzdy8q	57	33	Sglucosides	sglucoside	NNS
cord-033493-kslzdy8q	57	34	21a	21a	NNS
cord-033493-kslzdy8q	57	35	,	,	,
cord-033493-kslzdy8q	57	36	b	b	NN
cord-033493-kslzdy8q	57	37	,	,	,
cord-033493-kslzdy8q	57	38	respectively	respectively	RB
cord-033493-kslzdy8q	57	39	.	.	.
cord-033493-kslzdy8q	58	1	The	the	DT
cord-033493-kslzdy8q	58	2	chemical	chemical	JJ
cord-033493-kslzdy8q	58	3	structures	structure	NNS
cord-033493-kslzdy8q	58	4	of	of	IN
cord-033493-kslzdy8q	58	5	the	the	DT
cord-033493-kslzdy8q	58	6	prepared	prepared	JJ
cord-033493-kslzdy8q	58	7	compounds	compound	NNS
cord-033493-kslzdy8q	58	8	21a	21a	NNS
cord-033493-kslzdy8q	58	9	,	,	,
cord-033493-kslzdy8q	58	10	b	b	LS
cord-033493-kslzdy8q	58	11	were	be	VBD
cord-033493-kslzdy8q	58	12	confirmed	confirm	VBN
cord-033493-kslzdy8q	58	13	by	by	IN
cord-033493-kslzdy8q	58	14	elemental	elemental	JJ
cord-033493-kslzdy8q	58	15	analyses	analysis	NNS
cord-033493-kslzdy8q	58	16	and	and	CC
cord-033493-kslzdy8q	58	17	spectroscopy	spectroscopy	NN
cord-033493-kslzdy8q	58	18	(	(	-LRB-
cord-033493-kslzdy8q	58	19	1	1	CD
cord-033493-kslzdy8q	58	20	H	h	NN
cord-033493-kslzdy8q	58	21	NMR	nmr	NN
cord-033493-kslzdy8q	58	22	and	and	CC
cord-033493-kslzdy8q	58	23	IR	IR	NNP
cord-033493-kslzdy8q	58	24	)	)	-RRB-
cord-033493-kslzdy8q	58	25	studies	study	NNS
cord-033493-kslzdy8q	58	26	.	.	.
cord-033493-kslzdy8q	59	1	For	for	IN
cord-033493-kslzdy8q	59	2	example	example	NN
cord-033493-kslzdy8q	59	3	,	,	,
cord-033493-kslzdy8q	59	4	the	the	DT
cord-033493-kslzdy8q	59	5	1	1	CD
cord-033493-kslzdy8q	59	6	H	h	NN
cord-033493-kslzdy8q	59	7	NMR	nmr	NN
cord-033493-kslzdy8q	59	8	spectrum	spectrum	NN
cord-033493-kslzdy8q	59	9	of	of	IN
cord-033493-kslzdy8q	59	10	compound	compound	NN
cord-033493-kslzdy8q	59	11	21b	21b	NNS
cord-033493-kslzdy8q	59	12	showed	show	VBD
cord-033493-kslzdy8q	59	13	an	an	DT
cord-033493-kslzdy8q	59	14	anomeric	anomeric	JJ
cord-033493-kslzdy8q	59	15	proton	proton	NN
cord-033493-kslzdy8q	59	16	at	at	IN
cord-033493-kslzdy8q	59	17	δ	δ	NN
cord-033493-kslzdy8q	60	1	6.10−6.12	6.10−6.12	CD
cord-033493-kslzdy8q	60	2	ppm	ppm	NN
cord-033493-kslzdy8q	60	3	as	as	IN
cord-033493-kslzdy8q	60	4	a	a	DT
cord-033493-kslzdy8q	60	5	doublet	doublet	NN
cord-033493-kslzdy8q	60	6	,	,	,
cord-033493-kslzdy8q	60	7	and	and	CC
cord-033493-kslzdy8q	60	8	the	the	DT
cord-033493-kslzdy8q	60	9	coupling	coupling	NN
cord-033493-kslzdy8q	60	10	constant	constant	NN
cord-033493-kslzdy8q	60	11	(	(	-LRB-
cord-033493-kslzdy8q	60	12	J	J	NNP
cord-033493-kslzdy8q	60	13	1′,2′	1′,2′	CD
cord-033493-kslzdy8q	60	14	=	=	SYM
cord-033493-kslzdy8q	60	15	9.2	9.2	CD
cord-033493-kslzdy8q	60	16	Hz	Hz	NNP
cord-033493-kslzdy8q	60	17	)	)	-RRB-
cord-033493-kslzdy8q	60	18	proved	prove	VBD
cord-033493-kslzdy8q	61	1	H-1′to	H-1′to	NNS
cord-033493-kslzdy8q	61	2	be	be	VB
cord-033493-kslzdy8q	61	3	transdiaxial	transdiaxial	JJ
cord-033493-kslzdy8q	61	4	to	to	IN
cord-033493-kslzdy8q	61	5	H-2′.	h-2′.	NN
cord-033493-kslzdy8q	61	6	45−50	45−50	CD
cord-033493-kslzdy8q	62	1	The	the	DT
cord-033493-kslzdy8q	62	2	signals	signal	NNS
cord-033493-kslzdy8q	62	3	resonating	resonate	VBG
cord-033493-kslzdy8q	62	4	at	at	IN
cord-033493-kslzdy8q	62	5	3.92	3.92	CD
cord-033493-kslzdy8q	62	6	,	,	,
cord-033493-kslzdy8q	62	7	3.99	3.99	CD
cord-033493-kslzdy8q	62	8	,	,	,
cord-033493-kslzdy8q	62	9	4.04	4.04	CD
cord-033493-kslzdy8q	62	10	,	,	,
cord-033493-kslzdy8q	62	11	4.89	4.89	CD
cord-033493-kslzdy8q	62	12	,	,	,
cord-033493-kslzdy8q	62	13	5.03	5.03	CD
cord-033493-kslzdy8q	62	14	,	,	,
cord-033493-kslzdy8q	62	15	and	and	CC
cord-033493-kslzdy8q	62	16	5.61	5.61	CD
cord-033493-kslzdy8q	62	17	ppm	ppm	NN
cord-033493-kslzdy8q	62	18	are	be	VBP
cord-033493-kslzdy8q	62	19	assigned	assign	VBN
cord-033493-kslzdy8q	62	20	to	to	IN
cord-033493-kslzdy8q	62	21	six	six	CD
cord-033493-kslzdy8q	62	22	glucose	glucose	NN
cord-033493-kslzdy8q	62	23	protons	proton	NNS
cord-033493-kslzdy8q	62	24	,	,	,
cord-033493-kslzdy8q	62	25	and	and	CC
cord-033493-kslzdy8q	62	26	the	the	DT
cord-033493-kslzdy8q	62	27	four	four	CD
cord-033493-kslzdy8q	62	28	singlets	singlet	NNS
cord-033493-kslzdy8q	62	29	appearing	appear	VBG
cord-033493-kslzdy8q	62	30	from	from	IN
cord-033493-kslzdy8q	62	31	δ	δ	NN
cord-033493-kslzdy8q	62	32	1.59	1.59	CD
cord-033493-kslzdy8q	62	33	ppm	ppm	NN
cord-033493-kslzdy8q	62	34	to	to	IN
cord-033493-kslzdy8q	62	35	2.00	2.00	CD
cord-033493-kslzdy8q	62	36	ppm	ppm	NN
cord-033493-kslzdy8q	62	37	are	be	VBP
cord-033493-kslzdy8q	62	38	assigned	assign	VBN
cord-033493-kslzdy8q	62	39	to	to	IN
cord-033493-kslzdy8q	62	40	four	four	CD
cord-033493-kslzdy8q	62	41	acetyl	acetyl	NN
cord-033493-kslzdy8q	62	42	groups	group	NNS
cord-033493-kslzdy8q	62	43	.	.	.
cord-033493-kslzdy8q	63	1	The	the	DT
cord-033493-kslzdy8q	63	2	signal	signal	NN
cord-033493-kslzdy8q	63	3	for	for	IN
cord-033493-kslzdy8q	63	4	the	the	DT
cord-033493-kslzdy8q	63	5	C-1′	C-1′	NNP
cord-033493-kslzdy8q	63	6	atom	atom	NN
cord-033493-kslzdy8q	63	7	in	in	IN
cord-033493-kslzdy8q	63	8	the	the	DT
cord-033493-kslzdy8q	63	9	13	13	CD
cord-033493-kslzdy8q	63	10	C	c	NN
cord-033493-kslzdy8q	63	11	NMR	nmr	NN
cord-033493-kslzdy8q	63	12	spectrum	spectrum	NN
cord-033493-kslzdy8q	63	13	of	of	IN
cord-033493-kslzdy8q	63	14	21b	21b	NNS
cord-033493-kslzdy8q	63	15	appeared	appear	VBD
cord-033493-kslzdy8q	63	16	at	at	IN
cord-033493-kslzdy8q	63	17	δ	δ	NNP
cord-033493-kslzdy8q	63	18	80.31	80.31	CD
cord-033493-kslzdy8q	63	19	,	,	,
cord-033493-kslzdy8q	63	20	and	and	CC
cord-033493-kslzdy8q	63	21	the	the	DT
cord-033493-kslzdy8q	63	22	signals	signal	NNS
cord-033493-kslzdy8q	63	23	for	for	IN
cord-033493-kslzdy8q	63	24	C-6′	C-6′	NNP
cord-033493-kslzdy8q	63	25	,	,	,
cord-033493-kslzdy8q	63	26	C-4′	C-4′	NNP
cord-033493-kslzdy8q	63	27	,	,	,
cord-033493-kslzdy8q	63	28	C-2′	c-2′	RB
cord-033493-kslzdy8q	63	29	,	,	,
cord-033493-kslzdy8q	63	30	C-3′	C-3′	NNP
cord-033493-kslzdy8q	63	31	,	,	,
cord-033493-kslzdy8q	63	32	and	and	CC
cord-033493-kslzdy8q	63	33	C-5′	C-5′	NNP
cord-033493-kslzdy8q	63	34	appeared	appear	VBD
cord-033493-kslzdy8q	63	35	at	at	IN
cord-033493-kslzdy8q	63	36	δ	δ	NN
cord-033493-kslzdy8q	63	37	61.50	61.50	CD
cord-033493-kslzdy8q	63	38	,	,	,
cord-033493-kslzdy8q	63	39	68.76	68.76	CD
cord-033493-kslzdy8q	63	40	,	,	,
cord-033493-kslzdy8q	63	41	69.46	69.46	CD
cord-033493-kslzdy8q	63	42	,	,	,
cord-033493-kslzdy8q	63	43	73.47	73.47	CD
cord-033493-kslzdy8q	63	44	,	,	,
cord-033493-kslzdy8q	63	45	and	and	CC
cord-033493-kslzdy8q	63	46	79.82	79.82	CD
cord-033493-kslzdy8q	63	47	ppm	ppm	NN
cord-033493-kslzdy8q	63	48	,	,	,
cord-033493-kslzdy8q	63	49	respectively	respectively	RB
cord-033493-kslzdy8q	63	50	.	.	.
cord-033493-kslzdy8q	64	1	An	an	DT
cord-033493-kslzdy8q	64	2	attempt	attempt	NN
cord-033493-kslzdy8q	64	3	to	to	TO
cord-033493-kslzdy8q	64	4	remove	remove	VB
cord-033493-kslzdy8q	64	5	the	the	DT
cord-033493-kslzdy8q	64	6	protection	protection	NN
cord-033493-kslzdy8q	64	7	groups	group	NNS
cord-033493-kslzdy8q	64	8	at	at	IN
cord-033493-kslzdy8q	64	9	21	21	CD
cord-033493-kslzdy8q	64	10	by	by	IN
cord-033493-kslzdy8q	64	11	methanol−ammonia	methanol−ammonia	NNPS
cord-033493-kslzdy8q	64	12	did	do	VBD
cord-033493-kslzdy8q	64	13	not	not	RB
cord-033493-kslzdy8q	64	14	result	result	VB
cord-033493-kslzdy8q	64	15	in	in	IN
cord-033493-kslzdy8q	64	16	the	the	DT
cord-033493-kslzdy8q	64	17	formation	formation	NN
cord-033493-kslzdy8q	64	18	of	of	IN
cord-033493-kslzdy8q	64	19	the	the	DT
cord-033493-kslzdy8q	64	20	corresponding	correspond	VBG
cord-033493-kslzdy8q	64	21	free	free	JJ
cord-033493-kslzdy8q	64	22	glycosides	glycoside	NNS
cord-033493-kslzdy8q	64	23	.	.	.
cord-033493-kslzdy8q	65	1	The	the	DT
cord-033493-kslzdy8q	65	2	structure	structure	NN
cord-033493-kslzdy8q	65	3	21	21	CD
cord-033493-kslzdy8q	65	4	was	be	VBD
cord-033493-kslzdy8q	65	5	suggested	suggest	VBN
cord-033493-kslzdy8q	65	6	to	to	TO
cord-033493-kslzdy8q	65	7	be	be	VB
cord-033493-kslzdy8q	65	8	present	present	JJ
cord-033493-kslzdy8q	65	9	in	in	IN
cord-033493-kslzdy8q	65	10	the	the	DT
cord-033493-kslzdy8q	65	11	E	e	NN
cord-033493-kslzdy8q	65	12	form	form	NN
cord-033493-kslzdy8q	65	13	and	and	CC
cord-033493-kslzdy8q	65	14	not	not	RB
cord-033493-kslzdy8q	65	15	in	in	IN
cord-033493-kslzdy8q	65	16	the	the	DT
cord-033493-kslzdy8q	65	17	Z	z	NN
cord-033493-kslzdy8q	65	18	form	form	NN
cord-033493-kslzdy8q	65	19	,	,	,
cord-033493-kslzdy8q	65	20	which	which	WDT
cord-033493-kslzdy8q	65	21	was	be	VBD
cord-033493-kslzdy8q	65	22	demonstrated	demonstrate	VBN
cord-033493-kslzdy8q	65	23	by	by	IN
cord-033493-kslzdy8q	65	24	the	the	DT
cord-033493-kslzdy8q	65	25	reaction	reaction	NN
cord-033493-kslzdy8q	65	26	of	of	IN
cord-033493-kslzdy8q	65	27	compounds	compound	NNS
cord-033493-kslzdy8q	65	28	21	21	CD
cord-033493-kslzdy8q	65	29	with	with	IN
cord-033493-kslzdy8q	65	30	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	65	31	at	at	IN
cord-033493-kslzdy8q	65	32	room	room	NN
cord-033493-kslzdy8q	65	33	temperature	temperature	NN
cord-033493-kslzdy8q	65	34	in	in	IN
cord-033493-kslzdy8q	65	35	piperidine−ethanol	piperidine−ethanol	CD
cord-033493-kslzdy8q	65	36	to	to	TO
cord-033493-kslzdy8q	65	37	give	give	VB
cord-033493-kslzdy8q	65	38	the	the	DT
cord-033493-kslzdy8q	65	39	corresponding	corresponding	JJ
cord-033493-kslzdy8q	65	40	5-aminoprazole	5-aminoprazole	CD
cord-033493-kslzdy8q	65	41	4	4	CD
cord-033493-kslzdy8q	65	42	.	.	.
cord-033493-kslzdy8q	66	1	The	the	DT
cord-033493-kslzdy8q	66	2	structure	structure	NN
cord-033493-kslzdy8q	66	3	of	of	IN
cord-033493-kslzdy8q	66	4	4	4	CD
cord-033493-kslzdy8q	66	5	was	be	VBD
cord-033493-kslzdy8q	66	6	confirmed	confirm	VBN
cord-033493-kslzdy8q	66	7	on	on	IN
cord-033493-kslzdy8q	66	8	the	the	DT
cord-033493-kslzdy8q	66	9	basis	basis	NN
cord-033493-kslzdy8q	66	10	of	of	IN
cord-033493-kslzdy8q	66	11	elemental	elemental	JJ
cord-033493-kslzdy8q	66	12	analysis	analysis	NN
cord-033493-kslzdy8q	66	13	and	and	CC
cord-033493-kslzdy8q	66	14	spectral	spectral	JJ
cord-033493-kslzdy8q	66	15	data	datum	NNS
cord-033493-kslzdy8q	66	16	.	.	.
cord-033493-kslzdy8q	67	1	Antiviral	Antiviral	NNP
cord-033493-kslzdy8q	67	2	Activity	Activity	NNP
cord-033493-kslzdy8q	67	3	.	.	.
cord-033493-kslzdy8q	68	1	The	the	DT
cord-033493-kslzdy8q	68	2	antiviral	antiviral	JJ
cord-033493-kslzdy8q	68	3	activity	activity	NN
cord-033493-kslzdy8q	68	4	was	be	VBD
cord-033493-kslzdy8q	68	5	measured	measure	VBN
cord-033493-kslzdy8q	68	6	for	for	IN
cord-033493-kslzdy8q	68	7	the	the	DT
cord-033493-kslzdy8q	68	8	synthesized	synthesize	VBN
cord-033493-kslzdy8q	68	9	compounds	compound	NNS
cord-033493-kslzdy8q	68	10	with	with	IN
cord-033493-kslzdy8q	68	11	respect	respect	NN
cord-033493-kslzdy8q	68	12	to	to	IN
cord-033493-kslzdy8q	68	13	the	the	DT
cord-033493-kslzdy8q	68	14	H5N1	H5N1	NNP
cord-033493-kslzdy8q	68	15	influenza	influenza	NN
cord-033493-kslzdy8q	68	16	virus	virus	NN
cord-033493-kslzdy8q	68	17	strain	strain	VBP
cord-033493-kslzdy8q	68	18	A	a	DT
cord-033493-kslzdy8q	68	19	/	/	SYM
cord-033493-kslzdy8q	68	20	Egypt	Egypt	NNP
cord-033493-kslzdy8q	68	21	/	/	SYM
cord-033493-kslzdy8q	68	22	M7217B/2013	M7217B/2013	NNP
cord-033493-kslzdy8q	68	23	using	use	VBG
cord-033493-kslzdy8q	68	24	MTT	MTT	NNP
cord-033493-kslzdy8q	68	25	50	50	CD
cord-033493-kslzdy8q	68	26	)	)	-RRB-
cord-033493-kslzdy8q	68	27	and	and	CC
cord-033493-kslzdy8q	68	28	plaque	plaque	NN
cord-033493-kslzdy8q	68	29	reduction	reduction	NN
cord-033493-kslzdy8q	68	30	assays	assay	NNS
cord-033493-kslzdy8q	68	31	52	52	CD
cord-033493-kslzdy8q	68	32	exploring	explore	VBG
cord-033493-kslzdy8q	68	33	the	the	DT
cord-033493-kslzdy8q	68	34	cytotoxicity	cytotoxicity	NN
cord-033493-kslzdy8q	68	35	and	and	CC
cord-033493-kslzdy8q	68	36	inhibition	inhibition	NN
cord-033493-kslzdy8q	68	37	percentage	percentage	NN
cord-033493-kslzdy8q	68	38	values	value	NNS
cord-033493-kslzdy8q	68	39	,	,	,
cord-033493-kslzdy8q	68	40	respectively	respectively	RB
cord-033493-kslzdy8q	68	41	.	.	.
cord-033493-kslzdy8q	69	1	The	the	DT
cord-033493-kslzdy8q	69	2	anti	anti	JJ
cord-033493-kslzdy8q	69	3	-	-	JJ
cord-033493-kslzdy8q	69	4	influenza	influenza	JJ
cord-033493-kslzdy8q	69	5	drug	drug	NN
cord-033493-kslzdy8q	69	6	zanamivir	zanamivir	NNP
cord-033493-kslzdy8q	69	7	was	be	VBD
cord-033493-kslzdy8q	69	8	used	use	VBN
cord-033493-kslzdy8q	69	9	as	as	IN
cord-033493-kslzdy8q	69	10	a	a	DT
cord-033493-kslzdy8q	69	11	positive	positive	JJ
cord-033493-kslzdy8q	69	12	control	control	NN
cord-033493-kslzdy8q	69	13	.	.	.
cord-033493-kslzdy8q	70	1	53	53	CD
cord-033493-kslzdy8q	70	2	Antiviral	antiviral	JJ
cord-033493-kslzdy8q	70	3	bioassay	bioassay	NN
cord-033493-kslzdy8q	70	4	data	datum	NNS
cord-033493-kslzdy8q	70	5	(	(	-LRB-
cord-033493-kslzdy8q	70	6	see	see	VB
cord-033493-kslzdy8q	70	7	Table	table	NN
cord-033493-kslzdy8q	70	8	1	1	CD
cord-033493-kslzdy8q	70	9	and	and	CC
cord-033493-kslzdy8q	70	10	Figure	figure	NN
cord-033493-kslzdy8q	70	11	4	4	CD
cord-033493-kslzdy8q	70	12	)	)	-RRB-
cord-033493-kslzdy8q	70	13	indicated	indicate	VBD
cord-033493-kslzdy8q	70	14	that	that	IN
cord-033493-kslzdy8q	70	15	most	most	JJS
cord-033493-kslzdy8q	70	16	of	of	IN
cord-033493-kslzdy8q	70	17	the	the	DT
cord-033493-kslzdy8q	70	18	compounds	compound	NNS
cord-033493-kslzdy8q	70	19	demonstrated	demonstrate	VBD
cord-033493-kslzdy8q	70	20	a	a	DT
cord-033493-kslzdy8q	70	21	dosedependent	dosedependent	NN
cord-033493-kslzdy8q	70	22	inhibition	inhibition	NN
cord-033493-kslzdy8q	70	23	behavior	behavior	NN
cord-033493-kslzdy8q	70	24	.	.	.
cord-033493-kslzdy8q	71	1	Based	base	VBN
cord-033493-kslzdy8q	71	2	on	on	IN
cord-033493-kslzdy8q	71	3	the	the	DT
cord-033493-kslzdy8q	71	4	U.S.	U.S.	NNP
cord-033493-kslzdy8q	71	5	National	National	NNP
cord-033493-kslzdy8q	71	6	Cancer	Cancer	NNP
cord-033493-kslzdy8q	71	7	Institute	Institute	NNP
cord-033493-kslzdy8q	71	8	(	(	-LRB-
cord-033493-kslzdy8q	71	9	NCI	NCI	NNP
cord-033493-kslzdy8q	71	10	)	)	-RRB-
cord-033493-kslzdy8q	71	11	and	and	CC
cord-033493-kslzdy8q	71	12	GERAN	GERAN	NNP
cord-033493-kslzdy8q	71	13	protocol	protocol	NN
cord-033493-kslzdy8q	71	14	,	,	,
cord-033493-kslzdy8q	71	15	54,55	54,55	CD
cord-033493-kslzdy8q	71	16	the	the	DT
cord-033493-kslzdy8q	71	17	LD	LD	NNP
cord-033493-kslzdy8q	71	18	50	50	CD
cord-033493-kslzdy8q	71	19	values	value	NNS
cord-033493-kslzdy8q	71	20	indicate	indicate	VBP
cord-033493-kslzdy8q	71	21	that	that	IN
cord-033493-kslzdy8q	71	22	most	most	RBS
cord-033493-kslzdy8q	71	23	tested	test	VBN
cord-033493-kslzdy8q	71	24	compounds	compound	NNS
cord-033493-kslzdy8q	71	25	,	,	,
cord-033493-kslzdy8q	71	26	especially	especially	RB
cord-033493-kslzdy8q	71	27	compound	compound	NN
cord-033493-kslzdy8q	71	28	3b	3b	NNS
cord-033493-kslzdy8q	71	29	,	,	,
cord-033493-kslzdy8q	71	30	are	be	VBP
cord-033493-kslzdy8q	71	31	safe	safe	JJ
cord-033493-kslzdy8q	71	32	for	for	IN
cord-033493-kslzdy8q	71	33	healthy	healthy	JJ
cord-033493-kslzdy8q	71	34	cells	cell	NNS
cord-033493-kslzdy8q	71	35	,	,	,
cord-033493-kslzdy8q	71	36	while	while	IN
cord-033493-kslzdy8q	71	37	the	the	DT
cord-033493-kslzdy8q	71	38	plaque	plaque	NN
cord-033493-kslzdy8q	71	39	reduction	reduction	NN
cord-033493-kslzdy8q	71	40	assay	assay	NN
cord-033493-kslzdy8q	71	41	showed	show	VBD
cord-033493-kslzdy8q	71	42	that	that	IN
cord-033493-kslzdy8q	71	43	compounds	compound	NNS
cord-033493-kslzdy8q	71	44	3b	3b	CD
cord-033493-kslzdy8q	71	45	,	,	,
cord-033493-kslzdy8q	71	46	4	4	CD
cord-033493-kslzdy8q	71	47	,	,	,
cord-033493-kslzdy8q	71	48	and	and	CC
cord-033493-kslzdy8q	71	49	10b	10b	NNS
cord-033493-kslzdy8q	71	50	have	have	VBP
cord-033493-kslzdy8q	71	51	higher	high	JJR
cord-033493-kslzdy8q	71	52	therapeutic	therapeutic	JJ
cord-033493-kslzdy8q	71	53	indices	index	NNS
cord-033493-kslzdy8q	71	54	compared	compare	VBN
cord-033493-kslzdy8q	71	55	to	to	IN
cord-033493-kslzdy8q	71	56	the	the	DT
cord-033493-kslzdy8q	71	57	other	other	JJ
cord-033493-kslzdy8q	71	58	synthesized	synthesize	VBN
cord-033493-kslzdy8q	71	59	compounds	compound	NNS
cord-033493-kslzdy8q	71	60	.	.	.
cord-033493-kslzdy8q	72	1	In	in	IN
cord-033493-kslzdy8q	72	2	particular	particular	JJ
cord-033493-kslzdy8q	72	3	,	,	,
cord-033493-kslzdy8q	72	4	compound	compound	NN
cord-033493-kslzdy8q	72	5	3b	3b	CD
cord-033493-kslzdy8q	72	6	exhibited	exhibit	VBD
cord-033493-kslzdy8q	72	7	the	the	DT
cord-033493-kslzdy8q	72	8	highest	high	JJS
cord-033493-kslzdy8q	72	9	antiviral	antiviral	JJ
cord-033493-kslzdy8q	72	10	activity	activity	NN
cord-033493-kslzdy8q	72	11	at	at	IN
cord-033493-kslzdy8q	72	12	the	the	DT
cord-033493-kslzdy8q	72	13	given	give	VBN
cord-033493-kslzdy8q	72	14	concentrations	concentration	NNS
cord-033493-kslzdy8q	72	15	with	with	IN
cord-033493-kslzdy8q	72	16	percentage	percentage	NN
cord-033493-kslzdy8q	72	17	of	of	IN
cord-033493-kslzdy8q	72	18	virus	virus	NN
cord-033493-kslzdy8q	72	19	reduction	reduction	NN
cord-033493-kslzdy8q	72	20	reaching	reach	VBG
cord-033493-kslzdy8q	72	21	85	85	CD
cord-033493-kslzdy8q	72	22	%	%	NN
cord-033493-kslzdy8q	72	23	at	at	IN
cord-033493-kslzdy8q	72	24	a	a	DT
cord-033493-kslzdy8q	72	25	concentration	concentration	NN
cord-033493-kslzdy8q	72	26	of	of	IN
cord-033493-kslzdy8q	72	27	0.25	0.25	CD
cord-033493-kslzdy8q	72	28	μmol/	μmol/	NNS
cord-033493-kslzdy8q	72	29	ml	ml	NN
cord-033493-kslzdy8q	72	30	.	.	.
cord-033493-kslzdy8q	73	1	On	on	IN
cord-033493-kslzdy8q	73	2	the	the	DT
cord-033493-kslzdy8q	73	3	other	other	JJ
cord-033493-kslzdy8q	73	4	hand	hand	NN
cord-033493-kslzdy8q	73	5	,	,	,
cord-033493-kslzdy8q	73	6	compounds	compound	NNS
cord-033493-kslzdy8q	73	7	3c	3c	NNP
cord-033493-kslzdy8q	73	8	,	,	,
cord-033493-kslzdy8q	73	9	10c	10c	CD
cord-033493-kslzdy8q	73	10	,	,	,
cord-033493-kslzdy8q	73	11	12a	12a	NNS
cord-033493-kslzdy8q	73	12	,	,	,
cord-033493-kslzdy8q	73	13	19	19	CD
cord-033493-kslzdy8q	73	14	,	,	,
cord-033493-kslzdy8q	73	15	21a	21a	NNS
cord-033493-kslzdy8q	73	16	,	,	,
cord-033493-kslzdy8q	73	17	and	and	CC
cord-033493-kslzdy8q	73	18	21b	21b	NNS
cord-033493-kslzdy8q	73	19	demonstrated	demonstrate	VBD
cord-033493-kslzdy8q	73	20	a	a	DT
cord-033493-kslzdy8q	73	21	moderate	moderate	JJ
cord-033493-kslzdy8q	73	22	anti	anti	JJ
cord-033493-kslzdy8q	73	23	-	-	JJ
cord-033493-kslzdy8q	73	24	H5N1	h5n1	JJ
cord-033493-kslzdy8q	73	25	activity	activity	NN
cord-033493-kslzdy8q	73	26	with	with	IN
cord-033493-kslzdy8q	73	27	viral	viral	JJ
cord-033493-kslzdy8q	73	28	inhibition	inhibition	NN
cord-033493-kslzdy8q	73	29	over	over	IN
cord-033493-kslzdy8q	73	30	65	65	CD
cord-033493-kslzdy8q	73	31	percent	percent	NN
cord-033493-kslzdy8q	73	32	.	.	.
cord-033493-kslzdy8q	74	1	In	in	IN
cord-033493-kslzdy8q	74	2	general	general	JJ
cord-033493-kslzdy8q	74	3	,	,	,
cord-033493-kslzdy8q	74	4	it	-PRON-	PRP
cord-033493-kslzdy8q	74	5	has	have	VBZ
cord-033493-kslzdy8q	74	6	been	be	VBN
cord-033493-kslzdy8q	74	7	observed	observe	VBN
cord-033493-kslzdy8q	74	8	that	that	IN
cord-033493-kslzdy8q	74	9	compound	compound	NN
cord-033493-kslzdy8q	74	10	3b	3b	CD
cord-033493-kslzdy8q	74	11	with	with	IN
cord-033493-kslzdy8q	74	12	an	an	DT
cord-033493-kslzdy8q	74	13	ethylthio	ethylthio	JJ
cord-033493-kslzdy8q	74	14	group	group	NN
cord-033493-kslzdy8q	74	15	at	at	IN
cord-033493-kslzdy8q	74	16	a	a	DT
cord-033493-kslzdy8q	74	17	concentration	concentration	NN
cord-033493-kslzdy8q	74	18	of	of	IN
cord-033493-kslzdy8q	74	19	0.25	0.25	CD
cord-033493-kslzdy8q	74	20	μmol	μmol	NNP
cord-033493-kslzdy8q	74	21	/	/	SYM
cord-033493-kslzdy8q	74	22	ml	ml	NNP
cord-033493-kslzdy8q	74	23	was	be	VBD
cord-033493-kslzdy8q	74	24	more	more	RBR
cord-033493-kslzdy8q	74	25	active	active	JJ
cord-033493-kslzdy8q	74	26	compared	compare	VBN
cord-033493-kslzdy8q	74	27	to	to	IN
cord-033493-kslzdy8q	74	28	3a	3a	CD
cord-033493-kslzdy8q	74	29	and	and	CC
cord-033493-kslzdy8q	74	30	3c	3c	NNP
cord-033493-kslzdy8q	74	31	with	with	IN
cord-033493-kslzdy8q	74	32	methylthio	methylthio	NNP
cord-033493-kslzdy8q	74	33	and	and	CC
cord-033493-kslzdy8q	74	34	benzylthio	benzylthio	NNP
cord-033493-kslzdy8q	74	35	groups	group	NNS
cord-033493-kslzdy8q	74	36	,	,	,
cord-033493-kslzdy8q	74	37	respectively	respectively	RB
cord-033493-kslzdy8q	74	38	.	.	.
cord-033493-kslzdy8q	75	1	Additionally	additionally	RB
cord-033493-kslzdy8q	75	2	,	,	,
cord-033493-kslzdy8q	75	3	conversion	conversion	NN
cord-033493-kslzdy8q	75	4	of	of	IN
cord-033493-kslzdy8q	75	5	N-(2,2-dicyano-1-(alkylthio)vinyl)benzamides	N-(2,2-dicyano-1-(alkylthio)vinyl)benzamides	NNP
cord-033493-kslzdy8q	75	6	3a	3a	NNP
cord-033493-kslzdy8q	75	7	and	and	CC
cord-033493-kslzdy8q	75	8	3c	3c	NNP
cord-033493-kslzdy8q	75	9	to	to	IN
cord-033493-kslzdy8q	75	10	the	the	DT
cord-033493-kslzdy8q	75	11	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	75	12	4	4	CD
cord-033493-kslzdy8q	75	13	relatively	relatively	RB
cord-033493-kslzdy8q	75	14	enhanced	enhance	VBD
cord-033493-kslzdy8q	75	15	the	the	DT
cord-033493-kslzdy8q	75	16	activity	activity	NN
cord-033493-kslzdy8q	75	17	at	at	IN
cord-033493-kslzdy8q	75	18	the	the	DT
cord-033493-kslzdy8q	75	19	same	same	JJ
cord-033493-kslzdy8q	75	20	concentration	concentration	NN
cord-033493-kslzdy8q	75	21	.	.	.
cord-033493-kslzdy8q	76	1	The	the	DT
cord-033493-kslzdy8q	76	2	presence	presence	NN
cord-033493-kslzdy8q	76	3	of	of	IN
cord-033493-kslzdy8q	76	4	pyrazolotriazine	pyrazolotriazine	NN
cord-033493-kslzdy8q	76	5	moieties	moiety	NNS
cord-033493-kslzdy8q	76	6	in	in	IN
cord-033493-kslzdy8q	76	7	compounds	compound	NNS
cord-033493-kslzdy8q	76	8	6a	6a	NNP
cord-033493-kslzdy8q	76	9	,	,	,
cord-033493-kslzdy8q	76	10	b	b	NN
cord-033493-kslzdy8q	76	11	decreases	decrease	VBZ
cord-033493-kslzdy8q	76	12	the	the	DT
cord-033493-kslzdy8q	76	13	activity	activity	NN
cord-033493-kslzdy8q	76	14	compared	compare	VBN
cord-033493-kslzdy8q	76	15	to	to	IN
cord-033493-kslzdy8q	76	16	the	the	DT
cord-033493-kslzdy8q	76	17	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	76	18	4	4	CD
cord-033493-kslzdy8q	76	19	.	.	.
cord-033493-kslzdy8q	77	1	Compound	compound	NN
cord-033493-kslzdy8q	77	2	10b	10b	NNS
cord-033493-kslzdy8q	77	3	with	with	IN
cord-033493-kslzdy8q	77	4	a	a	DT
cord-033493-kslzdy8q	77	5	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	JJ
cord-033493-kslzdy8q	77	6	scaffold	scaffold	NN
cord-033493-kslzdy8q	77	7	and	and	CC
cord-033493-kslzdy8q	77	8	amino-	amino-	NN
cord-033493-kslzdy8q	77	9	,	,	,
cord-033493-kslzdy8q	77	10	cyano-	cyano-	JJ
cord-033493-kslzdy8q	77	11	,	,	,
cord-033493-kslzdy8q	77	12	and	and	CC
cord-033493-kslzdy8q	77	13	methoxy	methoxy	JJ
cord-033493-kslzdy8q	77	14	phenyl	phenyl	NN
cord-033493-kslzdy8q	77	15	groups	group	NNS
cord-033493-kslzdy8q	77	16	was	be	VBD
cord-033493-kslzdy8q	77	17	found	find	VBN
cord-033493-kslzdy8q	77	18	to	to	TO
cord-033493-kslzdy8q	77	19	have	have	VB
cord-033493-kslzdy8q	77	20	the	the	DT
cord-033493-kslzdy8q	77	21	highest	high	JJS
cord-033493-kslzdy8q	77	22	potency	potency	NN
cord-033493-kslzdy8q	77	23	in	in	IN
cord-033493-kslzdy8q	77	24	the	the	DT
cord-033493-kslzdy8q	77	25	series	series	NN
cord-033493-kslzdy8q	77	26	at	at	IN
cord-033493-kslzdy8q	77	27	a	a	DT
cord-033493-kslzdy8q	77	28	concentration	concentration	NN
cord-033493-kslzdy8q	77	29	of	of	IN
cord-033493-kslzdy8q	77	30	0.125	0.125	CD
cord-033493-kslzdy8q	77	31	μmol	μmol	NNP
cord-033493-kslzdy8q	77	32	/	/	SYM
cord-033493-kslzdy8q	77	33	ml	ml	NN
cord-033493-kslzdy8q	77	34	(	(	-LRB-
cord-033493-kslzdy8q	77	35	83	83	CD
cord-033493-kslzdy8q	77	36	%	%	NN
cord-033493-kslzdy8q	77	37	)	)	-RRB-
cord-033493-kslzdy8q	77	38	.	.	.
cord-033493-kslzdy8q	78	1	Unexpectedly	unexpectedly	RB
cord-033493-kslzdy8q	78	2	,	,	,
cord-033493-kslzdy8q	78	3	the	the	DT
cord-033493-kslzdy8q	78	4	synthesis	synthesis	NN
cord-033493-kslzdy8q	78	5	of	of	IN
cord-033493-kslzdy8q	78	6	derivatives	derivative	NNS
cord-033493-kslzdy8q	78	7	(	(	-LRB-
cord-033493-kslzdy8q	78	8	21a	21a	NNS
cord-033493-kslzdy8q	78	9	and	and	CC
cord-033493-kslzdy8q	78	10	21b	21b	NNS
cord-033493-kslzdy8q	78	11	)	)	-RRB-
cord-033493-kslzdy8q	78	12	with	with	IN
cord-033493-kslzdy8q	78	13	a	a	DT
cord-033493-kslzdy8q	78	14	sugar	sugar	NN
cord-033493-kslzdy8q	78	15	moiety	moiety	NN
cord-033493-kslzdy8q	78	16	had	have	VBD
cord-033493-kslzdy8q	78	17	no	no	DT
cord-033493-kslzdy8q	78	18	significant	significant	JJ
cord-033493-kslzdy8q	78	19	effect	effect	NN
cord-033493-kslzdy8q	78	20	on	on	IN
cord-033493-kslzdy8q	78	21	the	the	DT
cord-033493-kslzdy8q	78	22	antiviral	antiviral	JJ
cord-033493-kslzdy8q	78	23	activity	activity	NN
cord-033493-kslzdy8q	78	24	(	(	-LRB-
cord-033493-kslzdy8q	78	25	Scheme	scheme	NN
cord-033493-kslzdy8q	78	26	5	5	CD
cord-033493-kslzdy8q	78	27	)	)	-RRB-
cord-033493-kslzdy8q	78	28	,	,	,
cord-033493-kslzdy8q	78	29	where	where	WRB
cord-033493-kslzdy8q	78	30	the	the	DT
cord-033493-kslzdy8q	78	31	study	study	NN
cord-033493-kslzdy8q	78	32	showed	show	VBD
cord-033493-kslzdy8q	78	33	that	that	IN
cord-033493-kslzdy8q	78	34	N-(2,2-dicyano-1-(alkylthio)vinyl)benzamide	N-(2,2-dicyano-1-(alkylthio)vinyl)benzamide	NNP
cord-033493-kslzdy8q	78	35	3b	3b	CD
cord-033493-kslzdy8q	78	36	with	with	IN
cord-033493-kslzdy8q	78	37	S	S	NNP
cord-033493-kslzdy8q	78	38	-	-	HYPH
cord-033493-kslzdy8q	78	39	ethyl	ethyl	NNP
cord-033493-kslzdy8q	78	40	seemed	seem	VBD
cord-033493-kslzdy8q	78	41	to	to	TO
cord-033493-kslzdy8q	78	42	be	be	VB
cord-033493-kslzdy8q	78	43	more	more	RBR
cord-033493-kslzdy8q	78	44	active	active	JJ
cord-033493-kslzdy8q	78	45	than	than	IN
cord-033493-kslzdy8q	78	46	the	the	DT
cord-033493-kslzdy8q	78	47	corresponding	correspond	VBG
cord-033493-kslzdy8q	78	48	derivatives	derivative	NNS
cord-033493-kslzdy8q	78	49	of	of	IN
cord-033493-kslzdy8q	78	50	acyclic	acyclic	JJ
cord-033493-kslzdy8q	78	51	thioglucosides	thioglucoside	NNS
cord-033493-kslzdy8q	78	52	21a	21a	NNS
cord-033493-kslzdy8q	78	53	,	,	,
cord-033493-kslzdy8q	79	1	b.	b.	NNP
cord-033493-kslzdy8q	80	1	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	80	2	of	of	IN
cord-033493-kslzdy8q	80	3	N-(5-amino-3,6-dicyano-7-arylpyrazolo[1,5a]pyrimidin-2-yl)benzamides	N-(5-amino-3,6-dicyano-7-arylpyrazolo[1,5a]pyrimidin-2-yl)benzamides	NNP
cord-033493-kslzdy8q	80	4	10a−c	10a−c	CD
cord-033493-kslzdy8q	80	5	.	.	.
cord-033493-kslzdy8q	81	1	Method	method	NN
cord-033493-kslzdy8q	81	2	:	:	:
cord-033493-kslzdy8q	81	3	a	a	DT
cord-033493-kslzdy8q	81	4	mixture	mixture	NN
cord-033493-kslzdy8q	81	5	of	of	IN
cord-033493-kslzdy8q	81	6	compound	compound	NN
cord-033493-kslzdy8q	81	7	4	4	CD
cord-033493-kslzdy8q	81	8	(	(	-LRB-
cord-033493-kslzdy8q	81	9	2.27	2.27	CD
cord-033493-kslzdy8q	81	10	g	g	NN
cord-033493-kslzdy8q	81	11	,	,	,
cord-033493-kslzdy8q	81	12	0.01	0.01	CD
cord-033493-kslzdy8q	81	13	mol	mol	NN
cord-033493-kslzdy8q	81	14	)	)	-RRB-
cord-033493-kslzdy8q	81	15	and	and	CC
cord-033493-kslzdy8q	81	16	benzylidene	benzylidene	JJ
cord-033493-kslzdy8q	81	17	propane	propane	NN
cord-033493-kslzdy8q	81	18	-	-	HYPH
cord-033493-kslzdy8q	81	19	dinitrile	dinitrile	NN
cord-033493-kslzdy8q	81	20	9a	9a	NN
cord-033493-kslzdy8q	81	21	(	(	-LRB-
cord-033493-kslzdy8q	81	22	1.54	1.54	CD
cord-033493-kslzdy8q	81	23	g	g	NN
cord-033493-kslzdy8q	81	24	,	,	,
cord-033493-kslzdy8q	81	25	0.01	0.01	CD
cord-033493-kslzdy8q	81	26	mol	mol	NN
cord-033493-kslzdy8q	81	27	)	)	-RRB-
cord-033493-kslzdy8q	81	28	,	,	,
cord-033493-kslzdy8q	81	29	(	(	-LRB-
cord-033493-kslzdy8q	81	30	4-methoxy	4-methoxy	CD
cord-033493-kslzdy8q	81	31	benzylidene	benzylidene	NN
cord-033493-kslzdy8q	81	32	)	)	-RRB-
cord-033493-kslzdy8q	82	1	propanedinitrile	propanedinitrile	NNP
cord-033493-kslzdy8q	82	2	9b	9b	NNP
cord-033493-kslzdy8q	82	3	(	(	-LRB-
cord-033493-kslzdy8q	82	4	1.84	1.84	CD
cord-033493-kslzdy8q	82	5	g	g	NN
cord-033493-kslzdy8q	82	6	,	,	,
cord-033493-kslzdy8q	82	7	0.01	0.01	CD
cord-033493-kslzdy8q	82	8	mol	mol	NN
cord-033493-kslzdy8q	82	9	)	)	-RRB-
cord-033493-kslzdy8q	82	10	,	,	,
cord-033493-kslzdy8q	82	11	or	or	CC
cord-033493-kslzdy8q	82	12	(	(	-LRB-
cord-033493-kslzdy8q	82	13	4-chlorobenzylidene	4-chlorobenzylidene	CD
cord-033493-kslzdy8q	82	14	)	)	-RRB-
cord-033493-kslzdy8q	82	15	propanedinitrile	propanedinitrile	NNP
cord-033493-kslzdy8q	82	16	9c	9c	NNP
cord-033493-kslzdy8q	82	17	(	(	-LRB-
cord-033493-kslzdy8q	82	18	1.88	1.88	CD
cord-033493-kslzdy8q	82	19	g	g	NN
cord-033493-kslzdy8q	82	20	,	,	,
cord-033493-kslzdy8q	82	21	0.01	0.01	CD
cord-033493-kslzdy8q	82	22	mol	mol	NN
cord-033493-kslzdy8q	82	23	)	)	-RRB-
cord-033493-kslzdy8q	83	1	was	be	VBD
cord-033493-kslzdy8q	83	2	refluxed	refluxe	VBN
cord-033493-kslzdy8q	83	3	for	for	IN
cord-033493-kslzdy8q	83	4	5	5	CD
cord-033493-kslzdy8q	83	5	h	h	NN
cord-033493-kslzdy8q	83	6	in	in	IN
cord-033493-kslzdy8q	83	7	ethanol	ethanol	NN
cord-033493-kslzdy8q	83	8	(	(	-LRB-
cord-033493-kslzdy8q	83	9	20	20	CD
cord-033493-kslzdy8q	83	10	mL	ml	NN
cord-033493-kslzdy8q	83	11	)	)	-RRB-
cord-033493-kslzdy8q	83	12	containing	contain	VBG
cord-033493-kslzdy8q	83	13	drops	drop	NNS
cord-033493-kslzdy8q	83	14	of	of	IN
cord-033493-kslzdy8q	83	15	piperidine	piperidine	NN
cord-033493-kslzdy8q	83	16	.	.	.
cord-033493-kslzdy8q	84	1	The	the	DT
cord-033493-kslzdy8q	84	2	reaction	reaction	NN
cord-033493-kslzdy8q	84	3	mixture	mixture	NN
cord-033493-kslzdy8q	84	4	was	be	VBD
cord-033493-kslzdy8q	84	5	allowed	allow	VBN
cord-033493-kslzdy8q	84	6	to	to	TO
cord-033493-kslzdy8q	84	7	cool	cool	VB
cord-033493-kslzdy8q	84	8	to	to	IN
cord-033493-kslzdy8q	84	9	room	room	NN
cord-033493-kslzdy8q	84	10	temperature	temperature	NN
cord-033493-kslzdy8q	84	11	.	.	.
cord-033493-kslzdy8q	85	1	The	the	DT
cord-033493-kslzdy8q	85	2	precipitate	precipitate	NN
cord-033493-kslzdy8q	85	3	was	be	VBD
cord-033493-kslzdy8q	85	4	collected	collect	VBN
cord-033493-kslzdy8q	85	5	by	by	IN
cord-033493-kslzdy8q	85	6	filtration	filtration	NN
cord-033493-kslzdy8q	85	7	and	and	CC
cord-033493-kslzdy8q	85	8	crystallized	crystallize	VBN
cord-033493-kslzdy8q	85	9	from	from	IN
cord-033493-kslzdy8q	85	10	DMF	DMF	NNP
cord-033493-kslzdy8q	85	11	.	.	.
cord-033493-kslzdy8q	86	1	N-(5-Amino-3,6-dicyano-7-phenylpyrazolo[1,5-a]pyrimidin-2-yl)benzamide	n-(5-amino-3,6-dicyano-7-phenylpyrazolo[1,5-a]pyrimidin-2-yl)benzamide	RB
cord-033493-kslzdy8q	86	2	10a	10a	NNS
cord-033493-kslzdy8q	86	3	.	.	.
cord-033493-kslzdy8q	87	1	Yellow	yellow	JJ
cord-033493-kslzdy8q	87	2	powder	powder	NN
cord-033493-kslzdy8q	87	3	;	;	,
cord-033493-kslzdy8q	87	4	(	(	-LRB-
cord-033493-kslzdy8q	87	5	DMF	DMF	NNP
cord-033493-kslzdy8q	87	6	)	)	-RRB-
cord-033493-kslzdy8q	87	7	;	;	:
cord-033493-kslzdy8q	87	8	yield	yield	VBP
cord-033493-kslzdy8q	87	9	55	55	CD
cord-033493-kslzdy8q	87	10	%	%	NN
cord-033493-kslzdy8q	87	11	;	;	,
cord-033493-kslzdy8q	87	12	mp>300	mp>300	JJ
cord-033493-kslzdy8q	87	13	°	°	NN
cord-033493-kslzdy8q	87	14	C	c	NN
cord-033493-kslzdy8q	87	15	;	;	:
cord-033493-kslzdy8q	87	16	1	1	CD
cord-033493-kslzdy8q	87	17	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	87	18	of	of	IN
cord-033493-kslzdy8q	87	19	(	(	-LRB-
cord-033493-kslzdy8q	87	20	E)-Ethyl	E)-Ethyl	NNP
cord-033493-kslzdy8q	87	21	3-benzamido-2-cyano-3-(methylthio)acrylate	3-benzamido-2-cyano-3-(methylthio)acrylate	CD
cord-033493-kslzdy8q	87	22	14	14	CD
cord-033493-kslzdy8q	87	23	.	.	.
cord-033493-kslzdy8q	88	1	Method	method	NN
cord-033493-kslzdy8q	88	2	:	:	:
cord-033493-kslzdy8q	88	3	a	a	DT
cord-033493-kslzdy8q	88	4	mixture	mixture	NN
cord-033493-kslzdy8q	88	5	of	of	IN
cord-033493-kslzdy8q	88	6	ethyl	ethyl	NN
cord-033493-kslzdy8q	88	7	cyanoacetate	cyanoacetate	NN
cord-033493-kslzdy8q	88	8	(	(	-LRB-
cord-033493-kslzdy8q	88	9	1.13	1.13	CD
cord-033493-kslzdy8q	88	10	g	g	NN
cord-033493-kslzdy8q	88	11	,	,	,
cord-033493-kslzdy8q	88	12	0.01	0.01	CD
cord-033493-kslzdy8q	88	13	mol	mol	NN
cord-033493-kslzdy8q	88	14	)	)	-RRB-
cord-033493-kslzdy8q	88	15	and	and	CC
cord-033493-kslzdy8q	88	16	benzoyl	benzoyl	NN
cord-033493-kslzdy8q	88	17	isothiocyanate	isothiocyanate	NN
cord-033493-kslzdy8q	88	18	(	(	-LRB-
cord-033493-kslzdy8q	88	19	1.63	1.63	CD
cord-033493-kslzdy8q	88	20	g	g	NN
cord-033493-kslzdy8q	88	21	,	,	,
cord-033493-kslzdy8q	88	22	0.01	0.01	CD
cord-033493-kslzdy8q	88	23	mol	mol	NN
cord-033493-kslzdy8q	88	24	)	)	-RRB-
cord-033493-kslzdy8q	88	25	was	be	VBD
cord-033493-kslzdy8q	88	26	heated	heat	VBN
cord-033493-kslzdy8q	88	27	for	for	IN
cord-033493-kslzdy8q	88	28	30	30	CD
cord-033493-kslzdy8q	88	29	min	min	NN
cord-033493-kslzdy8q	88	30	in	in	IN
cord-033493-kslzdy8q	88	31	ethanol	ethanol	NN
cord-033493-kslzdy8q	88	32	(	(	-LRB-
cord-033493-kslzdy8q	88	33	25	25	CD
cord-033493-kslzdy8q	88	34	mL	ml	NN
cord-033493-kslzdy8q	88	35	)	)	-RRB-
cord-033493-kslzdy8q	88	36	in	in	IN
cord-033493-kslzdy8q	88	37	the	the	DT
cord-033493-kslzdy8q	88	38	presence	presence	NN
cord-033493-kslzdy8q	88	39	of	of	IN
cord-033493-kslzdy8q	88	40	potassium	potassium	NN
cord-033493-kslzdy8q	88	41	hydroxide	hydroxide	NN
cord-033493-kslzdy8q	88	42	(	(	-LRB-
cord-033493-kslzdy8q	88	43	0.56	0.56	CD
cord-033493-kslzdy8q	88	44	g	g	NN
cord-033493-kslzdy8q	88	45	,	,	,
cord-033493-kslzdy8q	88	46	0.01	0.01	CD
cord-033493-kslzdy8q	88	47	mol	mol	NN
cord-033493-kslzdy8q	88	48	)	)	-RRB-
cord-033493-kslzdy8q	88	49	.	.	.
cord-033493-kslzdy8q	89	1	After	after	IN
cord-033493-kslzdy8q	89	2	cooling	cool	VBG
cord-033493-kslzdy8q	89	3	,	,	,
cord-033493-kslzdy8q	89	4	methyl	methyl	NN
cord-033493-kslzdy8q	89	5	iodide	iodide	NN
cord-033493-kslzdy8q	89	6	(	(	-LRB-
cord-033493-kslzdy8q	89	7	1	1	CD
cord-033493-kslzdy8q	89	8	mmol	mmol	JJ
cord-033493-kslzdy8q	89	9	)	)	-RRB-
cord-033493-kslzdy8q	89	10	was	be	VBD
cord-033493-kslzdy8q	89	11	added	add	VBN
cord-033493-kslzdy8q	89	12	,	,	,
cord-033493-kslzdy8q	89	13	and	and	CC
cord-033493-kslzdy8q	89	14	the	the	DT
cord-033493-kslzdy8q	89	15	mixture	mixture	NN
cord-033493-kslzdy8q	89	16	was	be	VBD
cord-033493-kslzdy8q	89	17	stirred	stir	VBN
cord-033493-kslzdy8q	89	18	overnight	overnight	RB
cord-033493-kslzdy8q	89	19	.	.	.
cord-033493-kslzdy8q	90	1	The	the	DT
cord-033493-kslzdy8q	90	2	resulting	result	VBG
cord-033493-kslzdy8q	90	3	solid	solid	JJ
cord-033493-kslzdy8q	90	4	product	product	NN
cord-033493-kslzdy8q	90	5	was	be	VBD
cord-033493-kslzdy8q	90	6	collected	collect	VBN
cord-033493-kslzdy8q	90	7	by	by	IN
cord-033493-kslzdy8q	90	8	filtration	filtration	NN
cord-033493-kslzdy8q	90	9	and	and	CC
cord-033493-kslzdy8q	90	10	recrystallized	recrystallize	VBN
cord-033493-kslzdy8q	90	11	from	from	IN
cord-033493-kslzdy8q	90	12	ethanol	ethanol	NN
cord-033493-kslzdy8q	90	13	.	.	.
cord-033493-kslzdy8q	91	1	MTT	MTT	NNP
cord-033493-kslzdy8q	91	2	Cytotoxicity	Cytotoxicity	NNP
cord-033493-kslzdy8q	91	3	Assay	Assay	NNP
cord-033493-kslzdy8q	91	4	(	(	-LRB-
cord-033493-kslzdy8q	91	5	LD	LD	NNP
cord-033493-kslzdy8q	91	6	50	50	CD
cord-033493-kslzdy8q	91	7	)	)	-RRB-
cord-033493-kslzdy8q	91	8	.	.	.
cord-033493-kslzdy8q	92	1	The	the	DT
cord-033493-kslzdy8q	92	2	samples	sample	NNS
cord-033493-kslzdy8q	92	3	were	be	VBD
cord-033493-kslzdy8q	92	4	diluted	dilute	VBN
cord-033493-kslzdy8q	92	5	to	to	IN
cord-033493-kslzdy8q	92	6	10-fold	10-fold	CD
cord-033493-kslzdy8q	92	7	serially	serially	RB
cord-033493-kslzdy8q	92	8	using	use	VBG
cord-033493-kslzdy8q	92	9	the	the	DT
cord-033493-kslzdy8q	92	10	Dulbecco	Dulbecco	NNP
cord-033493-kslzdy8q	92	11	's	's	POS
cord-033493-kslzdy8q	92	12	modified	modify	VBN
cord-033493-kslzdy8q	92	13	Eagle	Eagle	NNP
cord-033493-kslzdy8q	92	14	's	's	POS
cord-033493-kslzdy8q	92	15	medium	medium	NN
cord-033493-kslzdy8q	92	16	(	(	-LRB-
cord-033493-kslzdy8q	92	17	DMEM	DMEM	NNP
cord-033493-kslzdy8q	92	18	)	)	-RRB-
cord-033493-kslzdy8q	92	19	.	.	.
cord-033493-kslzdy8q	93	1	51−56	51−56	CD
cord-033493-kslzdy8q	94	1	Then	then	RB
cord-033493-kslzdy8q	94	2	,	,	,
cord-033493-kslzdy8q	94	3	a	a	DT
cord-033493-kslzdy8q	94	4	preparation	preparation	NN
cord-033493-kslzdy8q	94	5	of	of	IN
cord-033493-kslzdy8q	94	6	test	test	NN
cord-033493-kslzdy8q	94	7	compound	compound	NN
cord-033493-kslzdy8q	94	8	stock	stock	NN
cord-033493-kslzdy8q	94	9	solutions	solution	NNS
cord-033493-kslzdy8q	94	10	was	be	VBD
cord-033493-kslzdy8q	94	11	carried	carry	VBN
cord-033493-kslzdy8q	94	12	out	out	RP
cord-033493-kslzdy8q	94	13	in	in	IN
cord-033493-kslzdy8q	94	14	diluted	dilute	VBN
cord-033493-kslzdy8q	94	15	DMSO	dmso	NN
cord-033493-kslzdy8q	94	16	with	with	IN
cord-033493-kslzdy8q	94	17	distilled	distil	VBN
cord-033493-kslzdy8q	94	18	water	water	NN
cord-033493-kslzdy8q	94	19	(	(	-LRB-
cord-033493-kslzdy8q	94	20	10	10	CD
cord-033493-kslzdy8q	94	21	%	%	NN
cord-033493-kslzdy8q	94	22	)	)	-RRB-
cord-033493-kslzdy8q	94	23	.	.	.
cord-033493-kslzdy8q	95	1	Cytotoxicity	cytotoxicity	NN
cord-033493-kslzdy8q	95	2	testing	testing	NN
cord-033493-kslzdy8q	95	3	of	of	IN
cord-033493-kslzdy8q	95	4	the	the	DT
cord-033493-kslzdy8q	95	5	extracts	extract	NNS
cord-033493-kslzdy8q	95	6	was	be	VBD
cord-033493-kslzdy8q	95	7	performed	perform	VBN
cord-033493-kslzdy8q	95	8	with	with	IN
cord-033493-kslzdy8q	95	9	Madin−Darby	Madin−Darby	NNP
cord-033493-kslzdy8q	95	10	canine	canine	JJ
cord-033493-kslzdy8q	95	11	kidney	kidney	NN
cord-033493-kslzdy8q	95	12	(	(	-LRB-
cord-033493-kslzdy8q	95	13	MDCK	MDCK	NNP
cord-033493-kslzdy8q	95	14	)	)	-RRB-
cord-033493-kslzdy8q	95	15	cells	cell	NNS
cord-033493-kslzdy8q	95	16	using	use	VBG
cord-033493-kslzdy8q	95	17	the	the	DT
cord-033493-kslzdy8q	95	18	method	method	NN
cord-033493-kslzdy8q	95	19	of	of	IN
cord-033493-kslzdy8q	95	20	MTT	MTT	NNP
cord-033493-kslzdy8q	95	21	(	(	-LRB-
cord-033493-kslzdy8q	95	22	3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium	3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium	CD
cord-033493-kslzdy8q	95	23	bromide	bromide	NN
cord-033493-kslzdy8q	95	24	)	)	-RRB-
cord-033493-kslzdy8q	95	25	51	51	CD
cord-033493-kslzdy8q	95	26	with	with	IN
cord-033493-kslzdy8q	95	27	some	some	DT
cord-033493-kslzdy8q	95	28	minor	minor	JJ
cord-033493-kslzdy8q	95	29	modifications	modification	NNS
cord-033493-kslzdy8q	95	30	.	.	.
cord-033493-kslzdy8q	96	1	Cells	cell	NNS
cord-033493-kslzdy8q	96	2	were	be	VBD
cord-033493-kslzdy8q	96	3	placed	place	VBN
cord-033493-kslzdy8q	96	4	in	in	IN
cord-033493-kslzdy8q	96	5	96-well	96-well	CD
cord-033493-kslzdy8q	96	6	plates	plate	NNS
cord-033493-kslzdy8q	96	7	and	and	CC
cord-033493-kslzdy8q	96	8	incubated	incubate	VBN
cord-033493-kslzdy8q	96	9	for	for	IN
cord-033493-kslzdy8q	96	10	1	1	CD
cord-033493-kslzdy8q	96	11	day	day	NN
cord-033493-kslzdy8q	96	12	at	at	IN
cord-033493-kslzdy8q	96	13	room	room	NN
cord-033493-kslzdy8q	96	14	temperature	temperature	NN
cord-033493-kslzdy8q	96	15	in	in	IN
cord-033493-kslzdy8q	96	16	5	5	CD
cord-033493-kslzdy8q	96	17	%	%	NN
cord-033493-kslzdy8q	96	18	CO	co	NN
cord-033493-kslzdy8q	96	19	2	2	CD
cord-033493-kslzdy8q	96	20	.	.	.
cord-033493-kslzdy8q	97	1	After	after	IN
cord-033493-kslzdy8q	97	2	1	1	CD
cord-033493-kslzdy8q	97	3	day	day	NN
cord-033493-kslzdy8q	97	4	,	,	,
cord-033493-kslzdy8q	97	5	the	the	DT
cord-033493-kslzdy8q	97	6	cells	cell	NNS
cord-033493-kslzdy8q	97	7	were	be	VBD
cord-033493-kslzdy8q	97	8	treated	treat	VBN
cord-033493-kslzdy8q	97	9	with	with	IN
cord-033493-kslzdy8q	97	10	different	different	JJ
cord-033493-kslzdy8q	97	11	concentrations	concentration	NNS
cord-033493-kslzdy8q	97	12	of	of	IN
cord-033493-kslzdy8q	97	13	the	the	DT
cord-033493-kslzdy8q	97	14	tested	test	VBN
cord-033493-kslzdy8q	97	15	compounds	compound	NNS
cord-033493-kslzdy8q	97	16	.	.	.
cord-033493-kslzdy8q	98	1	The	the	DT
cord-033493-kslzdy8q	98	2	supernatant	supernatant	NN
cord-033493-kslzdy8q	98	3	was	be	VBD
cord-033493-kslzdy8q	98	4	discarded	discard	VBN
cord-033493-kslzdy8q	98	5	after	after	IN
cord-033493-kslzdy8q	98	6	further	further	JJ
cord-033493-kslzdy8q	98	7	24	24	CD
cord-033493-kslzdy8q	98	8	h	h	NN
cord-033493-kslzdy8q	98	9	,	,	,
cord-033493-kslzdy8q	98	10	and	and	CC
cord-033493-kslzdy8q	98	11	the	the	DT
cord-033493-kslzdy8q	98	12	cell	cell	NN
cord-033493-kslzdy8q	98	13	monolayers	monolayer	NNS
cord-033493-kslzdy8q	98	14	were	be	VBD
cord-033493-kslzdy8q	98	15	washed	wash	VBN
cord-033493-kslzdy8q	98	16	with	with	IN
cord-033493-kslzdy8q	98	17	a	a	DT
cord-033493-kslzdy8q	98	18	solution	solution	NN
cord-033493-kslzdy8q	98	19	of	of	IN
cord-033493-kslzdy8q	98	20	phosphate	phosphate	NN
cord-033493-kslzdy8q	98	21	saline	saline	NN
cord-033493-kslzdy8q	98	22	(	(	-LRB-
cord-033493-kslzdy8q	98	23	PBS	PBS	NNP
cord-033493-kslzdy8q	98	24	)	)	-RRB-
cord-033493-kslzdy8q	98	25	.	.	.
cord-033493-kslzdy8q	99	1	An	an	DT
cord-033493-kslzdy8q	99	2	MTT	MTT	NNP
cord-033493-kslzdy8q	99	3	solution	solution	NN
cord-033493-kslzdy8q	99	4	was	be	VBD
cord-033493-kslzdy8q	99	5	added	add	VBN
cord-033493-kslzdy8q	99	6	to	to	IN
cord-033493-kslzdy8q	99	7	each	each	DT
cord-033493-kslzdy8q	99	8	well	well	RB
cord-033493-kslzdy8q	99	9	and	and	CC
cord-033493-kslzdy8q	99	10	incubated	incubate	VBN
cord-033493-kslzdy8q	99	11	at	at	IN
cord-033493-kslzdy8q	99	12	room	room	NN
cord-033493-kslzdy8q	99	13	temperature	temperature	NN
cord-033493-kslzdy8q	99	14	for	for	IN
cord-033493-kslzdy8q	99	15	4	4	CD
cord-033493-kslzdy8q	99	16	h	h	NN
cord-033493-kslzdy8q	99	17	,	,	,
cord-033493-kslzdy8q	99	18	and	and	CC
cord-033493-kslzdy8q	99	19	then	then	RB
cord-033493-kslzdy8q	99	20	,	,	,
cord-033493-kslzdy8q	99	21	a	a	DT
cord-033493-kslzdy8q	99	22	medium	medium	JJ
cord-033493-kslzdy8q	99	23	suction	suction	NN
cord-033493-kslzdy8q	99	24	was	be	VBD
cord-033493-kslzdy8q	99	25	applied	apply	VBN
cord-033493-kslzdy8q	99	26	.	.	.
cord-033493-kslzdy8q	100	1	The	the	DT
cord-033493-kslzdy8q	100	2	formazine	formazine	NN
cord-033493-kslzdy8q	100	3	crystals	crystal	NNS
cord-033493-kslzdy8q	100	4	formed	form	VBN
cord-033493-kslzdy8q	100	5	were	be	VBD
cord-033493-kslzdy8q	100	6	then	then	RB
cord-033493-kslzdy8q	100	7	dissolved	dissolve	VBN
cord-033493-kslzdy8q	100	8	in	in	IN
cord-033493-kslzdy8q	100	9	200	200	CD
cord-033493-kslzdy8q	100	10	μL	μL	NNS
cord-033493-kslzdy8q	100	11	of	of	IN
cord-033493-kslzdy8q	100	12	acidified	acidified	JJ
cord-033493-kslzdy8q	100	13	isopropanol	isopropanol	NN
cord-033493-kslzdy8q	100	14	.	.	.
cord-033493-kslzdy8q	101	1	The	the	DT
cord-033493-kslzdy8q	101	2	absorbance	absorbance	NN
cord-033493-kslzdy8q	101	3	measurement	measurement	NN
cord-033493-kslzdy8q	101	4	of	of	IN
cord-033493-kslzdy8q	101	5	the	the	DT
cord-033493-kslzdy8q	101	6	formazine	formazine	NNP
cord-033493-kslzdy8q	101	7	solutions	solution	NNS
cord-033493-kslzdy8q	101	8	at	at	IN
cord-033493-kslzdy8q	101	9	λ	λ	NNP
cord-033493-kslzdy8q	101	10	max	max	NNP
cord-033493-kslzdy8q	101	11	of	of	IN
cord-033493-kslzdy8q	101	12	540	540	CD
cord-033493-kslzdy8q	101	13	nm	nm	NN
cord-033493-kslzdy8q	101	14	with	with	IN
cord-033493-kslzdy8q	101	15	620	620	CD
cord-033493-kslzdy8q	101	16	nm	nm	NN
cord-033493-kslzdy8q	101	17	as	as	IN
cord-033493-kslzdy8q	101	18	the	the	DT
cord-033493-kslzdy8q	101	19	reference	reference	NN
cord-033493-kslzdy8q	101	20	wavelength	wavelength	NN
cord-033493-kslzdy8q	101	21	was	be	VBD
cord-033493-kslzdy8q	101	22	performed	perform	VBN
cord-033493-kslzdy8q	101	23	using	use	VBG
cord-033493-kslzdy8q	101	24	a	a	DT
cord-033493-kslzdy8q	101	25	multiplate	multiplate	NNP
cord-033493-kslzdy8q	101	26	reader	reader	NN
cord-033493-kslzdy8q	101	27	.	.	.
cord-033493-kslzdy8q	102	1	Then	then	RB
cord-033493-kslzdy8q	102	2	,	,	,
cord-033493-kslzdy8q	102	3	the	the	DT
cord-033493-kslzdy8q	102	4	determination	determination	NN
cord-033493-kslzdy8q	102	5	of	of	IN
cord-033493-kslzdy8q	102	6	the	the	DT
cord-033493-kslzdy8q	102	7	cytotoxicity	cytotoxicity	NN
cord-033493-kslzdy8q	102	8	compared	compare	VBN
cord-033493-kslzdy8q	102	9	to	to	IN
cord-033493-kslzdy8q	102	10	the	the	DT
cord-033493-kslzdy8q	102	11	untreated	untreated	JJ
cord-033493-kslzdy8q	102	12	cells	cell	NNS
cord-033493-kslzdy8q	102	13	was	be	VBD
cord-033493-kslzdy8q	102	14	performed	perform	VBN
cord-033493-kslzdy8q	102	15	using	use	VBG
cord-033493-kslzdy8q	102	16	the	the	DT
cord-033493-kslzdy8q	102	17	following	follow	VBG
cord-033493-kslzdy8q	102	18	equation	equation	NN
cord-033493-kslzdy8q	102	19	.	.	.
cord-033493-kslzdy8q	103	1	The	the	DT
cord-033493-kslzdy8q	103	2	plot	plot	NN
cord-033493-kslzdy8q	103	3	of	of	IN
cord-033493-kslzdy8q	103	4	cytotoxicity	cytotoxicity	NN
cord-033493-kslzdy8q	103	5	percentage	percentage	NN
cord-033493-kslzdy8q	103	6	versus	versus	IN
cord-033493-kslzdy8q	103	7	concentration	concentration	NN
cord-033493-kslzdy8q	103	8	of	of	IN
cord-033493-kslzdy8q	103	9	sample	sample	NN
cord-033493-kslzdy8q	103	10	was	be	VBD
cord-033493-kslzdy8q	103	11	used	use	VBN
cord-033493-kslzdy8q	103	12	to	to	TO
cord-033493-kslzdy8q	103	13	calculate	calculate	VB
cord-033493-kslzdy8q	103	14	the	the	DT
cord-033493-kslzdy8q	103	15	concentration	concentration	NN
cord-033493-kslzdy8q	103	16	,	,	,
cord-033493-kslzdy8q	103	17	which	which	WDT
cord-033493-kslzdy8q	103	18	showed	show	VBD
cord-033493-kslzdy8q	103	19	50	50	CD
cord-033493-kslzdy8q	103	20	%	%	NN
cord-033493-kslzdy8q	103	21	cytotoxicity	cytotoxicity	NN
cord-033493-kslzdy8q	103	22	(	(	-LRB-
cord-033493-kslzdy8q	103	23	LD	LD	NNP
cord-033493-kslzdy8q	103	24	50	50	CD
cord-033493-kslzdy8q	103	25	)	)	-RRB-
cord-033493-kslzdy8q	103	26	.	.	.
cord-033493-kslzdy8q	104	1	Plaque	Plaque	NNP
cord-033493-kslzdy8q	104	2	Reduction	Reduction	NNP
cord-033493-kslzdy8q	104	3	Assay	Assay	NNP
cord-033493-kslzdy8q	104	4	.	.	.
cord-033493-kslzdy8q	105	1	The	the	DT
cord-033493-kslzdy8q	105	2	plaque	plaque	NN
cord-033493-kslzdy8q	105	3	reduction	reduction	NN
cord-033493-kslzdy8q	105	4	assay	assay	NN
cord-033493-kslzdy8q	105	5	was	be	VBD
cord-033493-kslzdy8q	105	6	performed	perform	VBN
cord-033493-kslzdy8q	105	7	according	accord	VBG
cord-033493-kslzdy8q	105	8	to	to	IN
cord-033493-kslzdy8q	105	9	the	the	DT
cord-033493-kslzdy8q	105	10	method	method	NN
cord-033493-kslzdy8q	105	11	described	describe	VBN
cord-033493-kslzdy8q	105	12	by	by	IN
cord-033493-kslzdy8q	105	13	Hayden	Hayden	NNP
cord-033493-kslzdy8q	105	14	et	et	NNP
cord-033493-kslzdy8q	105	15	al	al	NNP
cord-033493-kslzdy8q	105	16	.	.	.
cord-033493-kslzdy8q	106	1	52	52	CD
cord-033493-kslzdy8q	106	2	in	in	IN
cord-033493-kslzdy8q	106	3	a	a	DT
cord-033493-kslzdy8q	106	4	plate	plate	NN
cord-033493-kslzdy8q	106	5	of	of	IN
cord-033493-kslzdy8q	106	6	six	six	CD
cord-033493-kslzdy8q	106	7	wells	well	NNS
cord-033493-kslzdy8q	106	8	in	in	IN
cord-033493-kslzdy8q	106	9	which	which	WDT
cord-033493-kslzdy8q	106	10	the	the	DT
cord-033493-kslzdy8q	106	11	MDCK	MDCK	NNP
cord-033493-kslzdy8q	106	12	cells	cell	NNS
cord-033493-kslzdy8q	106	13	(	(	-LRB-
cord-033493-kslzdy8q	106	14	105	105	CD
cord-033493-kslzdy8q	106	15	cells/	cells/	CD
cord-033493-kslzdy8q	106	16	ml	ml	NNS
cord-033493-kslzdy8q	106	17	)	)	-RRB-
cord-033493-kslzdy8q	106	18	were	be	VBD
cord-033493-kslzdy8q	106	19	cultivated	cultivate	VBN
cord-033493-kslzdy8q	106	20	for	for	IN
cord-033493-kslzdy8q	106	21	1	1	CD
cord-033493-kslzdy8q	106	22	day	day	NN
cord-033493-kslzdy8q	106	23	at	at	IN
cord-033493-kslzdy8q	106	24	room	room	NN
cord-033493-kslzdy8q	106	25	temperature	temperature	NN
cord-033493-kslzdy8q	106	26	.	.	.
cord-033493-kslzdy8q	107	1	51−56	51−56	CD
cord-033493-kslzdy8q	108	1	The	the	DT
cord-033493-kslzdy8q	108	2	virus	virus	NN
cord-033493-kslzdy8q	108	3	A	a	NN
cord-033493-kslzdy8q	108	4	/	/	SYM
cord-033493-kslzdy8q	108	5	CHICKEN/7217B/1/2013	CHICKEN/7217B/1/2013	NNP
cord-033493-kslzdy8q	108	6	(	(	-LRB-
cord-033493-kslzdy8q	108	7	H5N1	H5N1	NNP
cord-033493-kslzdy8q	108	8	)	)	-RRB-
cord-033493-kslzdy8q	108	9	was	be	VBD
cord-033493-kslzdy8q	108	10	diluted	dilute	VBN
cord-033493-kslzdy8q	108	11	to	to	TO
cord-033493-kslzdy8q	108	12	give	give	VB
cord-033493-kslzdy8q	108	13	105	105	CD
cord-033493-kslzdy8q	108	14	PFU	pfu	NN
cord-033493-kslzdy8q	108	15	/	/	SYM
cord-033493-kslzdy8q	108	16	well	well	RB
cord-033493-kslzdy8q	108	17	and	and	CC
cord-033493-kslzdy8q	108	18	mixed	mix	VBN
cord-033493-kslzdy8q	108	19	with	with	IN
cord-033493-kslzdy8q	108	20	the	the	DT
cord-033493-kslzdy8q	108	21	tested	test	VBN
cord-033493-kslzdy8q	108	22	samples	sample	NNS
cord-033493-kslzdy8q	108	23	and	and	CC
cord-033493-kslzdy8q	108	24	incubated	incubate	VBN
cord-033493-kslzdy8q	108	25	for	for	IN
cord-033493-kslzdy8q	108	26	half	half	JJ
cord-033493-kslzdy8q	108	27	hour	hour	NN
cord-033493-kslzdy8q	108	28	at	at	IN
cord-033493-kslzdy8q	108	29	room	room	NN
cord-033493-kslzdy8q	108	30	temperature	temperature	NN
cord-033493-kslzdy8q	108	31	before	before	IN
cord-033493-kslzdy8q	108	32	being	be	VBG
cord-033493-kslzdy8q	108	33	added	add	VBN
cord-033493-kslzdy8q	108	34	to	to	IN
cord-033493-kslzdy8q	108	35	the	the	DT
cord-033493-kslzdy8q	108	36	cells	cell	NNS
cord-033493-kslzdy8q	108	37	.	.	.
cord-033493-kslzdy8q	109	1	The	the	DT
cord-033493-kslzdy8q	109	2	growth	growth	NN
cord-033493-kslzdy8q	109	3	medium	medium	NN
cord-033493-kslzdy8q	109	4	was	be	VBD
cord-033493-kslzdy8q	109	5	removed	remove	VBN
cord-033493-kslzdy8q	109	6	from	from	IN
cord-033493-kslzdy8q	109	7	the	the	DT
cord-033493-kslzdy8q	109	8	cell	cell	NN
cord-033493-kslzdy8q	109	9	culture	culture	NN
cord-033493-kslzdy8q	109	10	plates	plate	NNS
cord-033493-kslzdy8q	109	11	,	,	,
cord-033493-kslzdy8q	109	12	and	and	CC
cord-033493-kslzdy8q	109	13	mixtures	mixture	NNS
cord-033493-kslzdy8q	109	14	of	of	IN
cord-033493-kslzdy8q	109	15	virus−Cpd	virus−cpd	NN
cord-033493-kslzdy8q	110	1	or	or	CC
cord-033493-kslzdy8q	110	2	virus−extract	virus−extract	CD
cord-033493-kslzdy8q	110	3	and	and	CC
cord-033493-kslzdy8q	110	4	virus−oseltamivir	virus−oseltamivir	NNP
cord-033493-kslzdy8q	110	5	(	(	-LRB-
cord-033493-kslzdy8q	110	6	100	100	CD
cord-033493-kslzdy8q	110	7	μL	μl	NN
cord-033493-kslzdy8q	110	8	/	/	SYM
cord-033493-kslzdy8q	110	9	well	well	RB
cord-033493-kslzdy8q	110	10	)	)	-RRB-
cord-033493-kslzdy8q	110	11	were	be	VBD
cord-033493-kslzdy8q	110	12	inoculated	inoculate	VBN
cord-033493-kslzdy8q	110	13	(	(	-LRB-
cord-033493-kslzdy8q	110	14	100	100	CD
cord-033493-kslzdy8q	110	15	μL	μl	NN
cord-033493-kslzdy8q	110	16	/	/	SYM
cord-033493-kslzdy8q	110	17	well	well	RB
cord-033493-kslzdy8q	110	18	)	)	-RRB-
cord-033493-kslzdy8q	110	19	.	.	.
cord-033493-kslzdy8q	111	1	After	after	IN
cord-033493-kslzdy8q	111	2	1	1	CD
cord-033493-kslzdy8q	111	3	hour	hour	NN
cord-033493-kslzdy8q	111	4	of	of	IN
cord-033493-kslzdy8q	111	5	contact	contact	NN
cord-033493-kslzdy8q	111	6	time	time	NN
cord-033493-kslzdy8q	111	7	for	for	IN
cord-033493-kslzdy8q	111	8	viral	viral	JJ
cord-033493-kslzdy8q	111	9	uptake	uptake	NN
cord-033493-kslzdy8q	111	10	,	,	,
cord-033493-kslzdy8q	111	11	3	3	CD
cord-033493-kslzdy8q	111	12	mL	ml	NN
cord-033493-kslzdy8q	111	13	of	of	IN
cord-033493-kslzdy8q	111	14	DMEM	DMEM	NNP
cord-033493-kslzdy8q	111	15	was	be	VBD
cord-033493-kslzdy8q	111	16	added	add	VBN
cord-033493-kslzdy8q	111	17	with	with	IN
cord-033493-kslzdy8q	111	18	2	2	CD
cord-033493-kslzdy8q	111	19	%	%	NN
cord-033493-kslzdy8q	111	20	agarose	agarose	JJ
cord-033493-kslzdy8q	111	21	on	on	IN
cord-033493-kslzdy8q	111	22	the	the	DT
cord-033493-kslzdy8q	111	23	monolayer	monolayer	NN
cord-033493-kslzdy8q	111	24	cell	cell	NN
cord-033493-kslzdy8q	111	25	,	,	,
cord-033493-kslzdy8q	111	26	and	and	CC
cord-033493-kslzdy8q	111	27	platelets	platelet	NNS
cord-033493-kslzdy8q	111	28	were	be	VBD
cord-033493-kslzdy8q	111	29	left	leave	VBN
cord-033493-kslzdy8q	111	30	to	to	TO
cord-033493-kslzdy8q	111	31	harden	harden	VB
cord-033493-kslzdy8q	111	32	and	and	CC
cord-033493-kslzdy8q	111	33	were	be	VBD
cord-033493-kslzdy8q	111	34	incubated	incubate	VBN
cord-033493-kslzdy8q	111	35	at	at	IN
cord-033493-kslzdy8q	111	36	room	room	NN
cord-033493-kslzdy8q	111	37	temperature	temperature	NN
cord-033493-kslzdy8q	111	38	until	until	IN
cord-033493-kslzdy8q	111	39	viral	viral	JJ
cord-033493-kslzdy8q	111	40	plaques	plaque	NNS
cord-033493-kslzdy8q	111	41	form	form	NN
cord-033493-kslzdy8q	111	42	(	(	-LRB-
cord-033493-kslzdy8q	111	43	3−4	3−4	CD
cord-033493-kslzdy8q	111	44	days	day	NNS
cord-033493-kslzdy8q	111	45	)	)	-RRB-
cord-033493-kslzdy8q	111	46	.	.	.
cord-033493-kslzdy8q	112	1	Formalin	Formalin	NNP
cord-033493-kslzdy8q	112	2	(	(	-LRB-
cord-033493-kslzdy8q	112	3	10	10	CD
cord-033493-kslzdy8q	112	4	%	%	NN
cord-033493-kslzdy8q	112	5	)	)	-RRB-
cord-033493-kslzdy8q	112	6	was	be	VBD
cord-033493-kslzdy8q	112	7	added	add	VBN
cord-033493-kslzdy8q	112	8	for	for	IN
cord-033493-kslzdy8q	112	9	2	2	CD
cord-033493-kslzdy8q	112	10	h	h	NN
cord-033493-kslzdy8q	112	11	,	,	,
cord-033493-kslzdy8q	112	12	and	and	CC
cord-033493-kslzdy8q	112	13	then	then	RB
cord-033493-kslzdy8q	112	14	,	,	,
cord-033493-kslzdy8q	112	15	the	the	DT
cord-033493-kslzdy8q	112	16	plates	plate	NNS
cord-033493-kslzdy8q	112	17	were	be	VBD
cord-033493-kslzdy8q	112	18	stained	stain	VBN
cord-033493-kslzdy8q	112	19	with	with	IN
cord-033493-kslzdy8q	112	20	0.1	0.1	CD
cord-033493-kslzdy8q	112	21	%	%	NN
cord-033493-kslzdy8q	112	22	crystal	crystal	NN
cord-033493-kslzdy8q	112	23	violet	violet	NN
cord-033493-kslzdy8q	112	24	in	in	IN
cord-033493-kslzdy8q	112	25	H	H	NNP
cord-033493-kslzdy8q	112	26	2	2	CD
cord-033493-kslzdy8q	112	27	O.	O.	NNP
cord-033493-kslzdy8q	112	28	Control	Control	NNP
cord-033493-kslzdy8q	112	29	wells	well	NNS
cord-033493-kslzdy8q	112	30	were	be	VBD
cord-033493-kslzdy8q	112	31	included	include	VBN
cord-033493-kslzdy8q	112	32	where	where	WRB
cord-033493-kslzdy8q	112	33	untreated	untreated	JJ
cord-033493-kslzdy8q	112	34	virus	virus	NN
cord-033493-kslzdy8q	112	35	was	be	VBD
cord-033493-kslzdy8q	112	36	incubated	incubate	VBN
cord-033493-kslzdy8q	112	37	with	with	IN
cord-033493-kslzdy8q	112	38	MDCK	MDCK	NNP
cord-033493-kslzdy8q	112	39	cells	cell	NNS
cord-033493-kslzdy8q	112	40	,	,	,
cord-033493-kslzdy8q	112	41	and	and	CC
cord-033493-kslzdy8q	112	42	at	at	IN
cord-033493-kslzdy8q	112	43	the	the	DT
cord-033493-kslzdy8q	112	44	end	end	NN
cord-033493-kslzdy8q	112	45	,	,	,
cord-033493-kslzdy8q	112	46	plaque	plaque	NN
cord-033493-kslzdy8q	112	47	was	be	VBD
cord-033493-kslzdy8q	112	48	counted	count	VBN
cord-033493-kslzdy8q	112	49	and	and	CC
cord-033493-kslzdy8q	112	50	the	the	DT
cord-033493-kslzdy8q	112	51	percentage	percentage	NN
cord-033493-kslzdy8q	112	52	decrease	decrease	NN
cord-033493-kslzdy8q	112	53	in	in	IN
cord-033493-kslzdy8q	112	54	plaque	plaque	NN
cord-033493-kslzdy8q	112	55	formation	formation	NN
cord-033493-kslzdy8q	112	56	compared	compare	VBN
cord-033493-kslzdy8q	112	57	to	to	TO
cord-033493-kslzdy8q	112	58	control	control	VB
cord-033493-kslzdy8q	112	59	wells	well	NNS
cord-033493-kslzdy8q	112	60	was	be	VBD
cord-033493-kslzdy8q	112	61	calculated	calculate	VBN
cord-033493-kslzdy8q	112	62	as	as	IN
cord-033493-kslzdy8q	112	63	follows	follow	VBZ
cord-033493-kslzdy8q	112	64	:	:	:
cord-033493-kslzdy8q	113	1	The	the	DT
cord-033493-kslzdy8q	113	2	Supporting	Supporting	NNP
cord-033493-kslzdy8q	113	3	Information	Information	NNP
cord-033493-kslzdy8q	113	4	is	be	VBZ
cord-033493-kslzdy8q	113	5	available	available	JJ
cord-033493-kslzdy8q	113	6	free	free	JJ
cord-033493-kslzdy8q	113	7	of	of	IN
cord-033493-kslzdy8q	113	8	charge	charge	NN
cord-033493-kslzdy8q	113	9	at	at	IN
cord-033493-kslzdy8q	113	10	https://pubs.acs.org/doi/10.1021/acsomega.0c02675	https://pubs.acs.org/doi/10.1021/acsomega.0c02675	NNP
cord-033493-kslzdy8q	113	11	.	.	.
cord-033493-kslzdy8q	114	1	All	all	DT
cord-033493-kslzdy8q	114	2	spectral	spectral	JJ
cord-033493-kslzdy8q	114	3	analysis	analysis	NN
cord-033493-kslzdy8q	114	4	data	datum	NNS
cord-033493-kslzdy8q	114	5	such	such	JJ
cord-033493-kslzdy8q	114	6	as	as	IN
cord-033493-kslzdy8q	114	7	IR	IR	NNP
cord-033493-kslzdy8q	114	8	,	,	,
cord-033493-kslzdy8q	114	9	1	1	CD
cord-033493-kslzdy8q	114	10	H	h	NN
cord-033493-kslzdy8q	114	11	NMR	nmr	NN
cord-033493-kslzdy8q	114	12	,	,	,
cord-033493-kslzdy8q	114	13	and	and	CC
cord-033493-kslzdy8q	114	14	13	13	CD
cord-033493-kslzdy8q	114	15	C	c	NN
cord-033493-kslzdy8q	114	16	NMR	NMR	NNP
cord-033493-kslzdy8q	114	17	spectra	spectra	NN
cord-033493-kslzdy8q	114	18	for	for	IN
cord-033493-kslzdy8q	114	19	the	the	DT
cord-033493-kslzdy8q	114	20	newly	newly	RB
cord-033493-kslzdy8q	114	21	synthesized	synthesize	VBN
cord-033493-kslzdy8q	114	22	compounds	compound	NNS
cord-033493-kslzdy8q	114	23	(	(	-LRB-
cord-033493-kslzdy8q	114	24	PDF	PDF	NNP
cord-033493-kslzdy8q	114	25	)	)	-RRB-
cord-033493-kslzdy8q	114	26	Yellow	yellow	JJ
cord-033493-kslzdy8q	114	27	powder	powder	NN
cord-033493-kslzdy8q	114	28	;	;	,
cord-033493-kslzdy8q	114	29	(	(	-LRB-
cord-033493-kslzdy8q	114	30	ethanol	ethanol	NN
cord-033493-kslzdy8q	114	31	)	)	-RRB-
cord-033493-kslzdy8q	114	32	;	;	:
cord-033493-kslzdy8q	114	33	yield	yield	VB
cord-033493-kslzdy8q	114	34	53	53	CD
cord-033493-kslzdy8q	114	35	%	%	NN
cord-033493-kslzdy8q	114	36	;	;	:
cord-033493-kslzdy8q	114	37	mp	mp	NNP
cord-033493-kslzdy8q	114	38	64	64	CD
cord-033493-kslzdy8q	114	39	°	°	NN
cord-033493-kslzdy8q	114	40	C	c	NN
cord-033493-kslzdy8q	114	41	;	;	:
cord-033493-kslzdy8q	114	42	1	1	CD
cord-033493-kslzdy8q	114	43	H	h	NN
cord-033493-kslzdy8q	114	44	NMR	nmr	NN
cord-033493-kslzdy8q	114	45	(	(	-LRB-
cord-033493-kslzdy8q	114	46	400	400	CD
cord-033493-kslzdy8q	114	47	MHz	MHz	NNPS
cord-033493-kslzdy8q	114	48	,	,	,
cord-033493-kslzdy8q	114	49	DMSO	DMSO	NNP
cord-033493-kslzdy8q	114	50	-	-	HYPH
cord-033493-kslzdy8q	114	51	d	d	NNP
cord-033493-kslzdy8q	114	52	6	6	CD
cord-033493-kslzdy8q	115	1	):	):	NNP
cord-033493-kslzdy8q	116	1	δ	δ	LS
cord-033493-kslzdy8q	116	2	1.36−1.41	1.36−1.41	CD
cord-033493-kslzdy8q	117	1	(	(	-LRB-
cord-033493-kslzdy8q	117	2	t	t	NNP
cord-033493-kslzdy8q	117	3	,	,	,
cord-033493-kslzdy8q	117	4	3H	3H	NNP
cord-033493-kslzdy8q	117	5	,	,	,
cord-033493-kslzdy8q	117	6	CH	CH	NNP
cord-033493-kslzdy8q	117	7	3	3	CD
cord-033493-kslzdy8q	117	8	)	)	-RRB-
cord-033493-kslzdy8q	117	9	,	,	,
cord-033493-kslzdy8q	117	10	2.39	2.39	CD
cord-033493-kslzdy8q	117	11	(	(	-LRB-
cord-033493-kslzdy8q	117	12	s	s	NNP
cord-033493-kslzdy8q	117	13	,	,	,
cord-033493-kslzdy8q	117	14	3H	3H	NNP
cord-033493-kslzdy8q	117	15	Method	Method	NNP
cord-033493-kslzdy8q	117	16	:	:	:
cord-033493-kslzdy8q	117	17	hydrazine	hydrazine	NN
cord-033493-kslzdy8q	117	18	hydrate	hydrate	NN
cord-033493-kslzdy8q	117	19	(	(	-LRB-
cord-033493-kslzdy8q	117	20	0,50	0,50	NNP
cord-033493-kslzdy8q	117	21	g	g	NN
cord-033493-kslzdy8q	117	22	,	,	,
cord-033493-kslzdy8q	117	23	0.01	0.01	CD
cord-033493-kslzdy8q	117	24	mol	mol	NN
cord-033493-kslzdy8q	117	25	)	)	-RRB-
cord-033493-kslzdy8q	117	26	was	be	VBD
cord-033493-kslzdy8q	117	27	added	add	VBN
cord-033493-kslzdy8q	117	28	to	to	IN
cord-033493-kslzdy8q	117	29	a	a	DT
cord-033493-kslzdy8q	117	30	solution	solution	NN
cord-033493-kslzdy8q	117	31	of	of	IN
cord-033493-kslzdy8q	117	32	(	(	-LRB-
cord-033493-kslzdy8q	117	33	E)-ethyl	E)-ethyl	NNP
cord-033493-kslzdy8q	117	34	3-benzamido-2-cyano-3-(methylthio	3-benzamido-2-cyano-3-(methylthio	CD
cord-033493-kslzdy8q	117	35	)	)	-RRB-
cord-033493-kslzdy8q	117	36	acrylate	acrylate	NN
cord-033493-kslzdy8q	117	37	(	(	-LRB-
cord-033493-kslzdy8q	117	38	14	14	CD
cord-033493-kslzdy8q	117	39	)	)	-RRB-
cord-033493-kslzdy8q	117	40	(	(	-LRB-
cord-033493-kslzdy8q	117	41	2.90	2.90	CD
cord-033493-kslzdy8q	117	42	g	g	NN
cord-033493-kslzdy8q	117	43	,	,	,
cord-033493-kslzdy8q	117	44	0.01	0.01	CD
cord-033493-kslzdy8q	117	45	mol	mol	NN
cord-033493-kslzdy8q	117	46	)	)	-RRB-
cord-033493-kslzdy8q	117	47	in	in	IN
cord-033493-kslzdy8q	117	48	ethanol	ethanol	NN
cord-033493-kslzdy8q	117	49	(	(	-LRB-
cord-033493-kslzdy8q	117	50	20	20	CD
cord-033493-kslzdy8q	117	51	mL	ml	NN
cord-033493-kslzdy8q	117	52	)	)	-RRB-
cord-033493-kslzdy8q	117	53	in	in	IN
cord-033493-kslzdy8q	117	54	the	the	DT
cord-033493-kslzdy8q	117	55	presence	presence	NN
cord-033493-kslzdy8q	117	56	of	of	IN
cord-033493-kslzdy8q	117	57	drops	drop	NNS
cord-033493-kslzdy8q	117	58	of	of	IN
cord-033493-kslzdy8q	117	59	piperidine	piperidine	NN
cord-033493-kslzdy8q	117	60	.	.	.
cord-033493-kslzdy8q	118	1	The	the	DT
cord-033493-kslzdy8q	118	2	mixture	mixture	NN
cord-033493-kslzdy8q	118	3	was	be	VBD
cord-033493-kslzdy8q	118	4	heated	heat	VBN
cord-033493-kslzdy8q	118	5	under	under	IN
cord-033493-kslzdy8q	118	6	reflux	reflux	NN
cord-033493-kslzdy8q	118	7	for	for	IN
cord-033493-kslzdy8q	118	8	2	2	CD
cord-033493-kslzdy8q	118	9	h	h	NN
cord-033493-kslzdy8q	118	10	and	and	CC
cord-033493-kslzdy8q	118	11	then	then	RB
cord-033493-kslzdy8q	118	12	poured	pour	VBD
cord-033493-kslzdy8q	118	13	onto	onto	IN
cord-033493-kslzdy8q	118	14	ice	ice	NN
cord-033493-kslzdy8q	118	15	.	.	.
cord-033493-kslzdy8q	119	1	The	the	DT
cord-033493-kslzdy8q	119	2	solid	solid	JJ
cord-033493-kslzdy8q	119	3	product	product	NN
cord-033493-kslzdy8q	119	4	was	be	VBD
cord-033493-kslzdy8q	119	5	filtered	filter	VBN
cord-033493-kslzdy8q	119	6	off	off	RP
cord-033493-kslzdy8q	119	7	,	,	,
cord-033493-kslzdy8q	119	8	dried	dry	VBN
cord-033493-kslzdy8q	119	9	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	119	10	of	of	IN
cord-033493-kslzdy8q	119	11	acyclic	acyclic	NNP
cord-033493-kslzdy8q	119	12	thioglucosides	thioglucoside	NNS
cord-033493-kslzdy8q	119	13	21a	21a	NNS
cord-033493-kslzdy8q	119	14	,	,	,
cord-033493-kslzdy8q	120	1	b.	b.	NNP
cord-033493-kslzdy8q	121	1	Method	method	NN
cord-033493-kslzdy8q	121	2	:	:	:
cord-033493-kslzdy8q	121	3	a	a	DT
cord-033493-kslzdy8q	121	4	mixture	mixture	NN
cord-033493-kslzdy8q	121	5	of	of	IN
cord-033493-kslzdy8q	121	6	malononitrile	malononitrile	NN
cord-033493-kslzdy8q	121	7	(	(	-LRB-
cord-033493-kslzdy8q	121	8	0.66	0.66	CD
cord-033493-kslzdy8q	121	9	g	g	NN
cord-033493-kslzdy8q	121	10	,	,	,
cord-033493-kslzdy8q	121	11	0.01	0.01	CD
cord-033493-kslzdy8q	121	12	mol	mol	NN
cord-033493-kslzdy8q	121	13	)	)	-RRB-
cord-033493-kslzdy8q	121	14	or	or	CC
cord-033493-kslzdy8q	121	15	ethyl	ethyl	NNP
cord-033493-kslzdy8q	121	16	cyanoacetate	cyanoacetate	NN
cord-033493-kslzdy8q	121	17	(	(	-LRB-
cord-033493-kslzdy8q	121	18	1.13	1.13	CD
cord-033493-kslzdy8q	121	19	g	g	NN
cord-033493-kslzdy8q	121	20	,	,	,
cord-033493-kslzdy8q	121	21	0.01	0.01	CD
cord-033493-kslzdy8q	121	22	mol	mol	NN
cord-033493-kslzdy8q	121	23	)	)	-RRB-
cord-033493-kslzdy8q	121	24	and	and	CC
cord-033493-kslzdy8q	121	25	benzoyl	benzoyl	NN
cord-033493-kslzdy8q	121	26	isothiocyanate	isothiocyanate	NN
cord-033493-kslzdy8q	121	27	(	(	-LRB-
cord-033493-kslzdy8q	121	28	1.63	1.63	CD
cord-033493-kslzdy8q	121	29	g	g	NN
cord-033493-kslzdy8q	121	30	,	,	,
cord-033493-kslzdy8q	121	31	0.01	0.01	CD
cord-033493-kslzdy8q	121	32	mol	mol	NN
cord-033493-kslzdy8q	121	33	)	)	-RRB-
cord-033493-kslzdy8q	121	34	was	be	VBD
cord-033493-kslzdy8q	121	35	heated	heat	VBN
cord-033493-kslzdy8q	121	36	for	for	IN
cord-033493-kslzdy8q	121	37	10−20	10−20	CD
cord-033493-kslzdy8q	121	38	min	min	NN
cord-033493-kslzdy8q	121	39	in	in	IN
cord-033493-kslzdy8q	121	40	ethanol	ethanol	NN
cord-033493-kslzdy8q	121	41	11	11	CD
cord-033493-kslzdy8q	121	42	g	g	NN
cord-033493-kslzdy8q	121	43	,	,	,
cord-033493-kslzdy8q	121	44	0.01	0.01	CD
cord-033493-kslzdy8q	121	45	mol	mol	NN
cord-033493-kslzdy8q	121	46	)	)	-RRB-
cord-033493-kslzdy8q	121	47	was	be	VBD
cord-033493-kslzdy8q	121	48	added	add	VBN
cord-033493-kslzdy8q	121	49	.	.	.
cord-033493-kslzdy8q	122	1	The	the	DT
cord-033493-kslzdy8q	122	2	reaction	reaction	NN
cord-033493-kslzdy8q	122	3	mixture	mixture	NN
cord-033493-kslzdy8q	122	4	was	be	VBD
cord-033493-kslzdy8q	122	5	stirred	stir	VBN
cord-033493-kslzdy8q	122	6	overnight	overnight	RB
cord-033493-kslzdy8q	122	7	at	at	IN
cord-033493-kslzdy8q	122	8	room	room	NN
cord-033493-kslzdy8q	122	9	temperature	temperature	NN
cord-033493-kslzdy8q	122	10	.	.	.
cord-033493-kslzdy8q	123	1	The	the	DT
cord-033493-kslzdy8q	123	2	resulting	result	VBG
cord-033493-kslzdy8q	123	3	solid	solid	NN
cord-033493-kslzdy8q	123	4	was	be	VBD
cord-033493-kslzdy8q	123	5	collected	collect	VBN
cord-033493-kslzdy8q	123	6	by	by	IN
cord-033493-kslzdy8q	123	7	filtration	filtration	NN
cord-033493-kslzdy8q	123	8	and	and	CC
cord-033493-kslzdy8q	123	9	was	be	VBD
cord-033493-kslzdy8q	123	10	separated	separate	VBN
cord-033493-kslzdy8q	123	11	from	from	IN
cord-033493-kslzdy8q	123	12	traces	trace	NNS
cord-033493-kslzdy8q	123	13	of	of	IN
cord-033493-kslzdy8q	123	14	the	the	DT
cord-033493-kslzdy8q	123	15	reactant	reactant	NN
cord-033493-kslzdy8q	123	16	by	by	IN
cord-033493-kslzdy8q	123	17	preparative	preparative	JJ
cord-033493-kslzdy8q	123	18	thinlayer	thinlayer	NN
cord-033493-kslzdy8q	123	19	chromatography	chromatography	NN
cord-033493-kslzdy8q	123	20	using	use	VBG
cord-033493-kslzdy8q	123	21	DCM	DCM	NNP
cord-033493-kslzdy8q	123	22	as	as	IN
cord-033493-kslzdy8q	123	23	an	an	DT
cord-033493-kslzdy8q	123	24	eluent	eluent	NN
cord-033493-kslzdy8q	123	25	where	where	WRB
cord-033493-kslzdy8q	123	26	compounds	compound	NNS
cord-033493-kslzdy8q	123	27	21a	21a	VBP
cord-033493-kslzdy8q	123	28	Yellow	yellow	JJ
cord-033493-kslzdy8q	123	29	powder	powder	NN
cord-033493-kslzdy8q	123	30	;	;	:
cord-033493-kslzdy8q	123	31	yield	yield	VBP
cord-033493-kslzdy8q	123	32	84	84	CD
cord-033493-kslzdy8q	123	33	%	%	NN
cord-033493-kslzdy8q	123	34	;	;	,
cord-033493-kslzdy8q	123	35	mp>300	mp>300	JJ
cord-033493-kslzdy8q	123	36	°	°	NN
cord-033493-kslzdy8q	123	37	C	c	NN
cord-033493-kslzdy8q	123	38	;	;	:
cord-033493-kslzdy8q	123	39	1	1	CD
cord-033493-kslzdy8q	123	40	H	h	NN
cord-033493-kslzdy8q	123	41	NMR	nmr	NN
cord-033493-kslzdy8q	123	42	(	(	-LRB-
cord-033493-kslzdy8q	123	43	400	400	CD
cord-033493-kslzdy8q	123	44	MHz	MHz	NNPS
cord-033493-kslzdy8q	123	45	,	,	.
cord-033493-kslzdy8q	124	1	DMSO	DMSO	NNP
cord-033493-kslzdy8q	124	2	-	-	HYPH
cord-033493-kslzdy8q	124	3	d	d	NNP
cord-033493-kslzdy8q	124	4	6	6	CD
cord-033493-kslzdy8q	124	5	):	):	NN
cord-033493-kslzdy8q	125	1	δ	δ	LS
cord-033493-kslzdy8q	125	2	1.18−1.27	1.18−1.27	CD
cord-033493-kslzdy8q	126	1	(	(	-LRB-
cord-033493-kslzdy8q	126	2	t	t	NNP
cord-033493-kslzdy8q	126	3	,	,	,
cord-033493-kslzdy8q	126	4	3H	3H	NNP
cord-033493-kslzdy8q	126	5	,	,	,
cord-033493-kslzdy8q	126	6	CH2-CH	CH2-CH	NNP
cord-033493-kslzdy8q	126	7	3	3	CD
cord-033493-kslzdy8q	126	8	)	)	-RRB-
cord-033493-kslzdy8q	126	9	,	,	,
cord-033493-kslzdy8q	126	10	1.59−2.00	1.59−2.00	CD
cord-033493-kslzdy8q	126	11	(	(	-LRB-
cord-033493-kslzdy8q	126	12	4	4	CD
cord-033493-kslzdy8q	126	13	s	s	NN
cord-033493-kslzdy8q	126	14	,	,	,
cord-033493-kslzdy8q	126	15	12H	12H	NNP
cord-033493-kslzdy8q	126	16	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	126	17	of	of	IN
cord-033493-kslzdy8q	126	18	new	new	JJ
cord-033493-kslzdy8q	126	19	pyrazole	pyrazole	NN
cord-033493-kslzdy8q	126	20	derivatives	derivative	NNS
cord-033493-kslzdy8q	126	21	and	and	CC
cord-033493-kslzdy8q	126	22	their	-PRON-	PRP$
cord-033493-kslzdy8q	126	23	anticancer	anticancer	JJ
cord-033493-kslzdy8q	126	24	evaluation	evaluation	NN
cord-033493-kslzdy8q	126	25	Antimicrobial	Antimicrobial	NNP
cord-033493-kslzdy8q	126	26	screening	screening	NN
cord-033493-kslzdy8q	126	27	and	and	CC
cord-033493-kslzdy8q	126	28	one	one	CD
cord-033493-kslzdy8q	126	29	-	-	HYPH
cord-033493-kslzdy8q	126	30	pot	pot	NN
cord-033493-kslzdy8q	126	31	synthesis	synthesis	NN
cord-033493-kslzdy8q	126	32	of	of	IN
cord-033493-kslzdy8q	126	33	4-(substituted	4-(substituted	CD
cord-033493-kslzdy8q	126	34	-	-	HYPH
cord-033493-kslzdy8q	126	35	anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H	anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H	NNP
cord-033493-kslzdy8q	126	36	-	-	HYPH
cord-033493-kslzdy8q	126	37	pyrazole	pyrazole	NN
cord-033493-kslzdy8q	126	38	derivatives	derivative	NNS
cord-033493-kslzdy8q	126	39	Fused	fuse	VBN
cord-033493-kslzdy8q	126	40	pyrazole	pyrazole	NN
cord-033493-kslzdy8q	126	41	derivatives	derivative	NNS
cord-033493-kslzdy8q	126	42	as	as	IN
cord-033493-kslzdy8q	126	43	kinase	kinase	NN
cord-033493-kslzdy8q	126	44	inhibitors	inhibitor	NNS
cord-033493-kslzdy8q	126	45	,	,	,
cord-033493-kslzdy8q	126	46	WO	WO	MD
cord-033493-kslzdy8q	126	47	Patent	patent	NN
cord-033493-kslzdy8q	126	48	Novel	Novel	NNP
cord-033493-kslzdy8q	126	49	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	126	50	and	and	CC
cord-033493-kslzdy8q	126	51	Biological	Biological	NNP
cord-033493-kslzdy8q	126	52	Evaluation	Evaluation	NNP
cord-033493-kslzdy8q	126	53	of	of	IN
cord-033493-kslzdy8q	126	54	the	the	DT
cord-033493-kslzdy8q	126	55	First	First	NNP
cord-033493-kslzdy8q	126	56	Pyrazole	Pyrazole	NNP
cord-033493-kslzdy8q	126	57	Thioglycosides	Thioglycosides	NNP
cord-033493-kslzdy8q	126	58	as	as	IN
cord-033493-kslzdy8q	126	59	Pyrazofurin	Pyrazofurin	NNP
cord-033493-kslzdy8q	126	60	Analogues	Analogues	NNP
cord-033493-kslzdy8q	126	61	Novel	Novel	NNP
cord-033493-kslzdy8q	126	62	synthesis	synthesis	NN
cord-033493-kslzdy8q	126	63	of	of	IN
cord-033493-kslzdy8q	126	64	new	new	JJ
cord-033493-kslzdy8q	126	65	pyrazole	pyrazole	NNP
cord-033493-kslzdy8q	126	66	thioglycosides	thioglycosides	NNP
cord-033493-kslzdy8q	126	67	as	as	IN
cord-033493-kslzdy8q	126	68	pyrazomycin	pyrazomycin	NNP
cord-033493-kslzdy8q	126	69	analogues	analogue	NNS
cord-033493-kslzdy8q	126	70	pyrimidine	pyrimidine	NN
cord-033493-kslzdy8q	126	71	TTK	TTK	NNP
cord-033493-kslzdy8q	126	72	Inhibitors	Inhibitors	NNPS
cord-033493-kslzdy8q	126	73	:	:	:
cord-033493-kslzdy8q	126	74	CFI-402257	CFI-402257	NNP
cord-033493-kslzdy8q	126	75	is	be	VBZ
cord-033493-kslzdy8q	126	76	a	a	DT
cord-033493-kslzdy8q	126	77	Potent	potent	JJ
cord-033493-kslzdy8q	126	78	,	,	,
cord-033493-kslzdy8q	126	79	Selective	selective	JJ
cord-033493-kslzdy8q	126	80	,	,	,
cord-033493-kslzdy8q	126	81	Bioavailable	Bioavailable	NNP
cord-033493-kslzdy8q	126	82	Anticancer	Anticancer	NNP
cord-033493-kslzdy8q	126	83	Agent	Agent	NNP
cord-033493-kslzdy8q	126	84	Design	Design	NNP
cord-033493-kslzdy8q	126	85	and	and	CC
cord-033493-kslzdy8q	126	86	synthesis	synthesis	NN
cord-033493-kslzdy8q	126	87	of	of	IN
cord-033493-kslzdy8q	126	88	novel	novel	JJ
cord-033493-kslzdy8q	126	89	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	JJ
cord-033493-kslzdy8q	126	90	derivatives	derivative	NNS
cord-033493-kslzdy8q	126	91	bearing	bear	VBG
cord-033493-kslzdy8q	126	92	nitrogen	nitrogen	NN
cord-033493-kslzdy8q	126	93	mustard	mustard	NN
cord-033493-kslzdy8q	126	94	moiety	moiety	NN
cord-033493-kslzdy8q	126	95	and	and	CC
cord-033493-kslzdy8q	126	96	evaluation	evaluation	NN
cord-033493-kslzdy8q	126	97	of	of	IN
cord-033493-kslzdy8q	126	98	their	-PRON-	PRP$
cord-033493-kslzdy8q	126	99	antitumor	antitumor	JJ
cord-033493-kslzdy8q	126	100	activity	activity	NN
cord-033493-kslzdy8q	126	101	in	in	IN
cord-033493-kslzdy8q	126	102	vitro	vitro	FW
cord-033493-kslzdy8q	126	103	and	and	CC
cord-033493-kslzdy8q	126	104	in	in	IN
cord-033493-kslzdy8q	126	105	vivo	vivo	NNP
cord-033493-kslzdy8q	126	106	Regioselective	Regioselective	NNP
cord-033493-kslzdy8q	126	107	synthesis	synthesis	NN
cord-033493-kslzdy8q	126	108	of	of	IN
cord-033493-kslzdy8q	126	109	1-and	1-and	CD
cord-033493-kslzdy8q	126	110	4-substituted	4-substituted	CD
cord-033493-kslzdy8q	126	111	7-oxopyrazolo[1,5-a]pyrimidine-3-carboxamides	7-oxopyrazolo[1,5-a]pyrimidine-3-carboxamides	CD
cord-033493-kslzdy8q	126	112	,	,	,
cord-033493-kslzdy8q	126	113	5-a]pyrimidine	5-a]pyrimidine	CD
cord-033493-kslzdy8q	126	114	-	-	HYPH
cord-033493-kslzdy8q	126	115	based	base	VBN
cord-033493-kslzdy8q	126	116	inhibitors	inhibitor	NNS
cord-033493-kslzdy8q	126	117	of	of	IN
cord-033493-kslzdy8q	126	118	HCV	HCV	NNP
cord-033493-kslzdy8q	126	119	polymerase	polymerase	NN
cord-033493-kslzdy8q	126	120	Discovery	Discovery	NNP
cord-033493-kslzdy8q	126	121	of	of	IN
cord-033493-kslzdy8q	126	122	Novel	Novel	NNP
cord-033493-kslzdy8q	126	123	2-Anilinopyrazolo[1,5-a]pyrimidine	2-anilinopyrazolo[1,5-a]pyrimidine	CD
cord-033493-kslzdy8q	126	124	Derivatives	Derivatives	NNPS
cord-033493-kslzdy8q	126	125	as	as	IN
cord-033493-kslzdy8q	126	126	c	c	NNP
cord-033493-kslzdy8q	126	127	-	-	HYPH
cord-033493-kslzdy8q	126	128	Src	Src	NNP
cord-033493-kslzdy8q	126	129	Kinase	Kinase	NNP
cord-033493-kslzdy8q	126	130	Inhibitors	Inhibitors	NNP
cord-033493-kslzdy8q	126	131	for	for	IN
cord-033493-kslzdy8q	126	132	the	the	DT
cord-033493-kslzdy8q	126	133	Treatment	Treatment	NNP
cord-033493-kslzdy8q	126	134	of	of	IN
cord-033493-kslzdy8q	126	135	Acute	Acute	NNP
cord-033493-kslzdy8q	126	136	Ischemic	Ischemic	NNP
cord-033493-kslzdy8q	126	137	Stroke	Stroke	NNP
cord-033493-kslzdy8q	126	138	Reactions	reaction	NNS
cord-033493-kslzdy8q	126	139	with	with	IN
cord-033493-kslzdy8q	126	140	3,5-Diaminopyrazoles	3,5-diaminopyrazoles	CD
cord-033493-kslzdy8q	126	141	:	:	:
cord-033493-kslzdy8q	126	142	New	new	JJ
cord-033493-kslzdy8q	126	143	Routes	route	NNS
cord-033493-kslzdy8q	126	144	to	to	IN
cord-033493-kslzdy8q	126	145	Pyrazolo[1,5-α]pyrimidines	Pyrazolo[1,5-α]pyrimidines	NNPS
cord-033493-kslzdy8q	126	146	Novel	Novel	NNP
cord-033493-kslzdy8q	126	147	synthesis	synthesis	NN
cord-033493-kslzdy8q	126	148	of	of	IN
cord-033493-kslzdy8q	126	149	mercaptopurine	mercaptopurine	NNP
cord-033493-kslzdy8q	126	150	and	and	CC
cord-033493-kslzdy8q	126	151	pentaaza	pentaaza	NNP
cord-033493-kslzdy8q	126	152	-	-	HYPH
cord-033493-kslzdy8q	126	153	as	as	IN
cord-033493-kslzdy8q	126	154	-	-	HYPH
cord-033493-kslzdy8q	126	155	indacene	indacene	NNP
cord-033493-kslzdy8q	127	1	analogues	analogue	NNS
cord-033493-kslzdy8q	127	2	:	:	:
cord-033493-kslzdy8q	127	3	Reaction	reaction	NN
cord-033493-kslzdy8q	127	4	of	of	IN
cord-033493-kslzdy8q	127	5	[	[	-LRB-
cord-033493-kslzdy8q	127	6	bis(methylthio)methylene]malononitrile	bis(methylthio)methylene]malononitrile	CD
cord-033493-kslzdy8q	127	7	and	and	CC
cord-033493-kslzdy8q	127	8	ethyl-2-cyano-3,3-bis(methylthio)acrylate	ethyl-2-cyano-3,3-bis(methylthio)acrylate	XX
cord-033493-kslzdy8q	127	9	with	with	IN
cord-033493-kslzdy8q	127	10	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	127	11	Design	Design	NNP
cord-033493-kslzdy8q	127	12	,	,	,
cord-033493-kslzdy8q	127	13	synthesis	synthesis	NN
cord-033493-kslzdy8q	127	14	,	,	,
cord-033493-kslzdy8q	127	15	docking	docking	NN
cord-033493-kslzdy8q	127	16	,	,	,
cord-033493-kslzdy8q	127	17	and	and	CC
cord-033493-kslzdy8q	127	18	antimicrobial	antimicrobial	JJ
cord-033493-kslzdy8q	127	19	evaluation	evaluation	NN
cord-033493-kslzdy8q	127	20	of	of	IN
cord-033493-kslzdy8q	127	21	some	some	DT
cord-033493-kslzdy8q	127	22	novel	novel	JJ
cord-033493-kslzdy8q	127	23	pyrazolo[1,5-a	pyrazolo[1,5-a	NN
cord-033493-kslzdy8q	127	24	]	]	-RRB-
cord-033493-kslzdy8q	127	25	pyrimidines	pyrimidine	NNS
cord-033493-kslzdy8q	127	26	and	and	CC
cord-033493-kslzdy8q	127	27	their	-PRON-	PRP$
cord-033493-kslzdy8q	127	28	corresponding	correspond	VBG
cord-033493-kslzdy8q	127	29	cycloalkane	cycloalkane	NN
cord-033493-kslzdy8q	127	30	ring	ring	NN
cord-033493-kslzdy8q	127	31	-	-	HYPH
cord-033493-kslzdy8q	127	32	fused	fuse	VBN
cord-033493-kslzdy8q	127	33	derivatives	derivative	NNS
cord-033493-kslzdy8q	127	34	as	as	IN
cord-033493-kslzdy8q	127	35	purine	purine	NNP
cord-033493-kslzdy8q	127	36	analogs	analogs	NNP
cord-033493-kslzdy8q	128	1	Potential	potential	JJ
cord-033493-kslzdy8q	128	2	purine	purine	NN
cord-033493-kslzdy8q	128	3	analogue	analogue	NN
cord-033493-kslzdy8q	128	4	antagonists	antagonist	NNS
cord-033493-kslzdy8q	128	5	:	:	:
cord-033493-kslzdy8q	128	6	Synthesis	synthesis	NN
cord-033493-kslzdy8q	128	7	of	of	IN
cord-033493-kslzdy8q	128	8	novel	novel	JJ
cord-033493-kslzdy8q	128	9	cycloalkane	cycloalkane	NN
cord-033493-kslzdy8q	128	10	ring	ring	NN
cord-033493-kslzdy8q	128	11	-	-	HYPH
cord-033493-kslzdy8q	128	12	fused	fuse	VBN
cord-033493-kslzdy8q	128	13	pyrazolo[1,5-a]pyrimidines	pyrazolo[1,5-a]pyrimidines	NNPS
cord-033493-kslzdy8q	128	14	1,3,5-Triazine	1,3,5-triazine	NN
cord-033493-kslzdy8q	128	15	-	-	HYPH
cord-033493-kslzdy8q	128	16	based	base	VBN
cord-033493-kslzdy8q	128	17	analogues	analogue	NNS
cord-033493-kslzdy8q	128	18	of	of	IN
cord-033493-kslzdy8q	128	19	purine	purine	NN
cord-033493-kslzdy8q	128	20	:	:	:
cord-033493-kslzdy8q	129	1	From	from	IN
cord-033493-kslzdy8q	129	2	isosteres	isostere	NNS
cord-033493-kslzdy8q	129	3	to	to	IN
cord-033493-kslzdy8q	129	4	privileged	privileged	JJ
cord-033493-kslzdy8q	129	5	scaffolds	scaffold	NNS
cord-033493-kslzdy8q	129	6	in	in	IN
cord-033493-kslzdy8q	129	7	medicinal	medicinal	JJ
cord-033493-kslzdy8q	129	8	chemistry	chemistry	NN
cord-033493-kslzdy8q	129	9	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	129	10	and	and	CC
cord-033493-kslzdy8q	129	11	biological	biological	JJ
cord-033493-kslzdy8q	129	12	activity	activity	NN
cord-033493-kslzdy8q	129	13	yl)benzamides	yl)benzamide	NNS
cord-033493-kslzdy8q	129	14	as	as	IN
cord-033493-kslzdy8q	129	15	novel	novel	NN
cord-033493-kslzdy8q	129	16	,	,	,
cord-033493-kslzdy8q	129	17	highly	highly	RB
cord-033493-kslzdy8q	129	18	potent	potent	JJ
cord-033493-kslzdy8q	129	19	and	and	CC
cord-033493-kslzdy8q	129	20	selective	selective	JJ
cord-033493-kslzdy8q	129	21	,	,	,
cord-033493-kslzdy8q	129	22	orally	orally	RB
cord-033493-kslzdy8q	129	23	bioavailable	bioavailable	JJ
cord-033493-kslzdy8q	129	24	inhibitors	inhibitor	NNS
cord-033493-kslzdy8q	129	25	of	of	IN
cord-033493-kslzdy8q	129	26	Tyrosine	Tyrosine	NNP
cord-033493-kslzdy8q	129	27	Threonine	Threonine	NNP
cord-033493-kslzdy8q	129	28	Kinase	Kinase	NNP
cord-033493-kslzdy8q	129	29	TTK	TTK	NNP
cord-033493-kslzdy8q	129	30	Reactions	reaction	NNS
cord-033493-kslzdy8q	129	31	of	of	IN
cord-033493-kslzdy8q	129	32	chlorocarbonyl	chlorocarbonyl	NN
cord-033493-kslzdy8q	129	33	isocyanate	isocyanate	NN
cord-033493-kslzdy8q	129	34	with	with	IN
cord-033493-kslzdy8q	129	35	5-aminopyrazoles	5-aminopyrazoles	CD
cord-033493-kslzdy8q	129	36	and	and	CC
cord-033493-kslzdy8q	129	37	active	active	JJ
cord-033493-kslzdy8q	129	38	methylene	methylene	NN
cord-033493-kslzdy8q	129	39	nitriles	nitrile	NNS
cord-033493-kslzdy8q	129	40	:	:	:
cord-033493-kslzdy8q	129	41	A	a	DT
cord-033493-kslzdy8q	129	42	novel	novel	JJ
cord-033493-kslzdy8q	129	43	synthesis	synthesis	NN
cord-033493-kslzdy8q	129	44	of	of	IN
cord-033493-kslzdy8q	129	45	pyrazolo[1,5-a]-1,3,5-triazines	pyrazolo[1,5-a]-1,3,5-triazines	NNPS
cord-033493-kslzdy8q	129	46	and	and	CC
cord-033493-kslzdy8q	129	47	barbiturates	barbiturate	NNS
cord-033493-kslzdy8q	130	1	The	the	DT
cord-033493-kslzdy8q	130	2	reaction	reaction	NN
cord-033493-kslzdy8q	130	3	of	of	IN
cord-033493-kslzdy8q	130	4	dimethyl	dimethyl	NN
cord-033493-kslzdy8q	130	5	Ncyanodithioiminocarbonate	Ncyanodithioiminocarbonate	NNP
cord-033493-kslzdy8q	130	6	with	with	IN
cord-033493-kslzdy8q	130	7	amino	amino	NN
cord-033493-kslzdy8q	130	8	-	-	:
cord-033493-kslzdy8q	130	9	and	and	CC
cord-033493-kslzdy8q	130	10	oxo	oxo	NN
cord-033493-kslzdy8q	130	11	-	-	HYPH
cord-033493-kslzdy8q	130	12	azoles	azole	NNS
cord-033493-kslzdy8q	130	13	:	:	:
cord-033493-kslzdy8q	130	14	a	a	DT
cord-033493-kslzdy8q	130	15	new	new	JJ
cord-033493-kslzdy8q	130	16	general	general	JJ
cord-033493-kslzdy8q	130	17	synthesis	synthesis	NN
cord-033493-kslzdy8q	130	18	of	of	IN
cord-033493-kslzdy8q	130	19	methylsulfanylazoloazines	methylsulfanylazoloazine	NNS
cord-033493-kslzdy8q	130	20	5-amino-3-anilino	5-amino-3-anilino	NNP
cord-033493-kslzdy8q	130	21	-	-	HYPH
cord-033493-kslzdy8q	130	22	N-(chlorophenyl)-1H	n-(chlorophenyl)-1h	NN
cord-033493-kslzdy8q	130	23	-	-	HYPH
cord-033493-kslzdy8q	130	24	pyrazole-4-carboxamide	pyrazole-4-carboxamide	JJ
cord-033493-kslzdy8q	130	25	ethanol	ethanol	NN
cord-033493-kslzdy8q	130	26	solvate	solvate	NN
cord-033493-kslzdy8q	130	27	Novel	novel	JJ
cord-033493-kslzdy8q	130	28	synthesis	synthesis	NN
cord-033493-kslzdy8q	130	29	of	of	IN
cord-033493-kslzdy8q	130	30	fluorinated	fluorinate	VBN
cord-033493-kslzdy8q	130	31	cyanoketene	cyanoketene	NNP
cord-033493-kslzdy8q	130	32	N	N	NNP
cord-033493-kslzdy8q	130	33	,	,	,
cord-033493-kslzdy8q	130	34	S	S	NNP
cord-033493-kslzdy8q	130	35	-	-	HYPH
cord-033493-kslzdy8q	130	36	acetals	acetal	NNS
cord-033493-kslzdy8q	130	37	and	and	CC
cord-033493-kslzdy8q	130	38	their	-PRON-	PRP$
cord-033493-kslzdy8q	130	39	conversions	conversion	NNS
cord-033493-kslzdy8q	130	40	to	to	IN
cord-033493-kslzdy8q	130	41	fluorinated	fluorinate	VBN
cord-033493-kslzdy8q	130	42	pyrazole	pyrazole	NN
cord-033493-kslzdy8q	130	43	derivatives	derivative	NNS
cord-033493-kslzdy8q	130	44	.	.	.
cord-033493-kslzdy8q	131	1	Phosphor	Phosphor	NNP
cord-033493-kslzdy8q	131	2	.	.	.
cord-033493-kslzdy8q	132	1	Sulfur	Sulfur	NNP
cord-033493-kslzdy8q	132	2	Silicon	Silicon	NNP
cord-033493-kslzdy8q	132	3	Relat	Relat	NNP
cord-033493-kslzdy8q	132	4	Novel	Novel	NNP
cord-033493-kslzdy8q	132	5	cyanoketene	cyanoketene	NNP
cord-033493-kslzdy8q	132	6	N	N	NNP
cord-033493-kslzdy8q	132	7	,	,	,
cord-033493-kslzdy8q	132	8	S	S	NNP
cord-033493-kslzdy8q	132	9	-	-	HYPH
cord-033493-kslzdy8q	132	10	acetals	acetal	NNS
cord-033493-kslzdy8q	132	11	and	and	CC
cord-033493-kslzdy8q	132	12	pyrazole	pyrazole	NN
cord-033493-kslzdy8q	132	13	derivatives	derivative	NNS
cord-033493-kslzdy8q	132	14	using	use	VBG
cord-033493-kslzdy8q	132	15	potassium	potassium	NN
cord-033493-kslzdy8q	132	16	2-cyanoethylene-1-thiolates	2-cyanoethylene-1-thiolates	CD
cord-033493-kslzdy8q	132	17	Direct	direct	JJ
cord-033493-kslzdy8q	132	18	route	route	NN
cord-033493-kslzdy8q	132	19	to	to	IN
cord-033493-kslzdy8q	132	20	a	a	DT
cord-033493-kslzdy8q	132	21	new	new	JJ
cord-033493-kslzdy8q	132	22	class	class	NN
cord-033493-kslzdy8q	132	23	of	of	IN
cord-033493-kslzdy8q	132	24	acrylamide	acrylamide	NN
cord-033493-kslzdy8q	132	25	thioglycosides	thioglycoside	NNS
cord-033493-kslzdy8q	132	26	and	and	CC
cord-033493-kslzdy8q	132	27	their	-PRON-	PRP$
cord-033493-kslzdy8q	132	28	conversions	conversion	NNS
cord-033493-kslzdy8q	132	29	to	to	IN
cord-033493-kslzdy8q	132	30	pyrazole	pyrazole	NNP
cord-033493-kslzdy8q	132	31	derivatives	derivative	NNS
cord-033493-kslzdy8q	132	32	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	132	33	of	of	IN
cord-033493-kslzdy8q	132	34	some	some	DT
cord-033493-kslzdy8q	132	35	novel	novel	NN
cord-033493-kslzdy8q	132	36	α	α	NN
cord-033493-kslzdy8q	132	37	-	-	HYPH
cord-033493-kslzdy8q	132	38	cyanoketene	cyanoketene	NNP
cord-033493-kslzdy8q	132	39	S	S	NNP
cord-033493-kslzdy8q	132	40	,	,	,
cord-033493-kslzdy8q	132	41	S	S	NNP
cord-033493-kslzdy8q	132	42	-	-	HYPH
cord-033493-kslzdy8q	132	43	acetals	acetal	NNS
cord-033493-kslzdy8q	132	44	and	and	CC
cord-033493-kslzdy8q	132	45	their	-PRON-	PRP$
cord-033493-kslzdy8q	132	46	use	use	NN
cord-033493-kslzdy8q	132	47	in	in	IN
cord-033493-kslzdy8q	132	48	heterocyclic	heterocyclic	JJ
cord-033493-kslzdy8q	132	49	synthesis	synthesis	NN
cord-033493-kslzdy8q	133	1	Potassium	potassium	NN
cord-033493-kslzdy8q	133	2	2-cyanoethylene-1-thiolate	2-cyanoethylene-1-thiolate	CD
cord-033493-kslzdy8q	133	3	derivatives	derivative	NNS
cord-033493-kslzdy8q	133	4	:	:	:
cord-033493-kslzdy8q	133	5	A	a	DT
cord-033493-kslzdy8q	133	6	new	new	JJ
cord-033493-kslzdy8q	133	7	preparative	preparative	JJ
cord-033493-kslzdy8q	133	8	route	route	NN
cord-033493-kslzdy8q	133	9	to	to	IN
cord-033493-kslzdy8q	133	10	2-cyanoketene	2-cyanoketene	NNP
cord-033493-kslzdy8q	133	11	S	S	NNP
cord-033493-kslzdy8q	133	12	,	,	,
cord-033493-kslzdy8q	133	13	N	N	NNP
cord-033493-kslzdy8q	133	14	-	-	HYPH
cord-033493-kslzdy8q	133	15	acetals	acetal	NNS
cord-033493-kslzdy8q	133	16	and	and	CC
cord-033493-kslzdy8q	133	17	pyrazole	pyrazole	NNP
cord-033493-kslzdy8q	133	18	derivatives	derivative	NNS
cord-033493-kslzdy8q	133	19	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	133	20	of	of	IN
cord-033493-kslzdy8q	133	21	some	some	DT
cord-033493-kslzdy8q	133	22	Pyrazolopyrimidines	Pyrazolopyrimidines	NNPS
cord-033493-kslzdy8q	133	23	as	as	IN
cord-033493-kslzdy8q	133	24	Purine	Purine	NNP
cord-033493-kslzdy8q	133	25	Analogues	Analogues	NNP
cord-033493-kslzdy8q	133	26	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	133	27	and	and	CC
cord-033493-kslzdy8q	133	28	anti	anti	JJ
cord-033493-kslzdy8q	133	29	-	-	JJ
cord-033493-kslzdy8q	133	30	tumor	tumor	JJ
cord-033493-kslzdy8q	133	31	activities	activity	NNS
cord-033493-kslzdy8q	133	32	of	of	IN
cord-033493-kslzdy8q	133	33	some	some	DT
cord-033493-kslzdy8q	133	34	new	new	JJ
cord-033493-kslzdy8q	133	35	pyridines	pyridine	NNS
cord-033493-kslzdy8q	133	36	and	and	CC
cord-033493-kslzdy8q	133	37	pyrazolo[1,5-a]pyrimidines	pyrazolo[1,5-a]pyrimidines	NNPS
cord-033493-kslzdy8q	133	38	Cyanoacetanilides	Cyanoacetanilides	NNP
cord-033493-kslzdy8q	133	39	intermediates	intermediate	NNS
cord-033493-kslzdy8q	133	40	in	in	IN
cord-033493-kslzdy8q	133	41	heterocyclic	heterocyclic	JJ
cord-033493-kslzdy8q	133	42	synthesis	synthesis	NN
cord-033493-kslzdy8q	133	43	.	.	.
cord-033493-kslzdy8q	134	1	Part	part	NN
cord-033493-kslzdy8q	134	2	5	5	CD
cord-033493-kslzdy8q	134	3	:	:	:
cord-033493-kslzdy8q	134	4	Preparation	preparation	NN
cord-033493-kslzdy8q	134	5	of	of	IN
cord-033493-kslzdy8q	134	6	hitherto	hitherto	VBD
cord-033493-kslzdy8q	134	7	unknown	unknown	JJ
cord-033493-kslzdy8q	134	8	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	134	9	and	and	CC
cord-033493-kslzdy8q	134	10	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	JJ
cord-033493-kslzdy8q	134	11	derivatives	derivative	NNS
cord-033493-kslzdy8q	134	12	containing	contain	VBG
cord-033493-kslzdy8q	134	13	sulfamoyl	sulfamoyl	NNP
cord-033493-kslzdy8q	134	14	moiety	moiety	NNP
cord-033493-kslzdy8q	134	15	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	134	16	of	of	IN
cord-033493-kslzdy8q	134	17	some	some	DT
cord-033493-kslzdy8q	134	18	new	new	JJ
cord-033493-kslzdy8q	134	19	purine	purine	NN
cord-033493-kslzdy8q	134	20	-	-	HYPH
cord-033493-kslzdy8q	134	21	related	relate	VBN
cord-033493-kslzdy8q	134	22	compounds	compound	NNS
cord-033493-kslzdy8q	134	23	:	:	:
cord-033493-kslzdy8q	135	1	Regioselective	Regioselective	NNP
cord-033493-kslzdy8q	135	2	one	one	CD
cord-033493-kslzdy8q	135	3	-	-	HYPH
cord-033493-kslzdy8q	135	4	pot	pot	NN
cord-033493-kslzdy8q	135	5	synthesis	synthesis	NN
cord-033493-kslzdy8q	135	6	of	of	IN
cord-033493-kslzdy8q	135	7	new	new	JJ
cord-033493-kslzdy8q	135	8	tetrazolo[1,5-a]pyrimidine	tetrazolo[1,5-a]pyrimidine	NNP
cord-033493-kslzdy8q	135	9	,	,	,
cord-033493-kslzdy8q	135	10	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	NNP
cord-033493-kslzdy8q	135	11	and	and	CC
cord-033493-kslzdy8q	135	12	pyrimido[1,6-a]-pyrimidine	pyrimido[1,6-a]-pyrimidine	NNP
cord-033493-kslzdy8q	136	1	derivatives	derivative	NNS
cord-033493-kslzdy8q	136	2	Novel	Novel	NNP
cord-033493-kslzdy8q	136	3	synthesis	synthesis	NN
cord-033493-kslzdy8q	136	4	of	of	IN
cord-033493-kslzdy8q	136	5	some	some	DT
cord-033493-kslzdy8q	136	6	new	new	JJ
cord-033493-kslzdy8q	136	7	pyrimido[1,6-a]pyrimidine	pyrimido[1,6-a]pyrimidine	NN
cord-033493-kslzdy8q	136	8	and	and	CC
cord-033493-kslzdy8q	136	9	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	JJ
cord-033493-kslzdy8q	136	10	derivatives	derivative	NNS
cord-033493-kslzdy8q	136	11	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	136	12	and	and	CC
cord-033493-kslzdy8q	137	1	in	in	IN
cord-033493-kslzdy8q	137	2	vitro	vitro	FW
cord-033493-kslzdy8q	137	3	cytotoxic	cytotoxic	JJ
cord-033493-kslzdy8q	137	4	activity	activity	NN
cord-033493-kslzdy8q	137	5	of	of	IN
cord-033493-kslzdy8q	137	6	novel	novel	NN
cord-033493-kslzdy8q	137	7	pyrazolo[1,5-a]pyrimidines	pyrazolo[1,5-a]pyrimidine	NNS
cord-033493-kslzdy8q	137	8	and	and	CC
cord-033493-kslzdy8q	137	9	related	relate	VBN
cord-033493-kslzdy8q	137	10	Schiff	Schiff	NNP
cord-033493-kslzdy8q	137	11	bases	basis	NNS
cord-033493-kslzdy8q	137	12	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	137	13	,	,	,
cord-033493-kslzdy8q	137	14	Characterization	characterization	NN
cord-033493-kslzdy8q	137	15	,	,	,
cord-033493-kslzdy8q	137	16	and	and	CC
cord-033493-kslzdy8q	137	17	Cytotoxicity	Cytotoxicity	NNP
cord-033493-kslzdy8q	137	18	of	of	IN
cord-033493-kslzdy8q	137	19	some	some	DT
cord-033493-kslzdy8q	137	20	new	new	JJ
cord-033493-kslzdy8q	137	21	5-aminopyrazole	5-aminopyrazole	CD
cord-033493-kslzdy8q	137	22	and	and	CC
cord-033493-kslzdy8q	137	23	pyrazolo[1,5-a]pyrimidine	pyrazolo[1,5-a]pyrimidine	NNP
cord-033493-kslzdy8q	138	1	derivatives	derivative	NNS
cord-033493-kslzdy8q	138	2	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	138	3	and	and	CC
cord-033493-kslzdy8q	138	4	antitumor	antitumor	JJ
cord-033493-kslzdy8q	138	5	activity	activity	NN
cord-033493-kslzdy8q	138	6	of	of	IN
cord-033493-kslzdy8q	138	7	some	some	DT
cord-033493-kslzdy8q	138	8	new	new	JJ
cord-033493-kslzdy8q	138	9	pyrazolo[1,5-a]pyrimidines	pyrazolo[1,5-a]pyrimidines	NNPS
cord-033493-kslzdy8q	138	10	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	138	11	,	,	,
cord-033493-kslzdy8q	138	12	Structural	Structural	NNP
cord-033493-kslzdy8q	138	13	Elucidation	Elucidation	NNP
cord-033493-kslzdy8q	138	14	,	,	,
cord-033493-kslzdy8q	138	15	and	and	CC
cord-033493-kslzdy8q	138	16	in	in	IN
cord-033493-kslzdy8q	138	17	vitro	vitro	FW
cord-033493-kslzdy8q	138	18	Antitumor	Antitumor	NNP
cord-033493-kslzdy8q	138	19	Activities	Activities	NNPS
cord-033493-kslzdy8q	138	20	of	of	IN
cord-033493-kslzdy8q	138	21	Some	some	DT
cord-033493-kslzdy8q	138	22	Pyrazolopyrimidines	Pyrazolopyrimidines	NNPS
cord-033493-kslzdy8q	138	23	and	and	CC
cord-033493-kslzdy8q	138	24	schiff	schiff	NNP
cord-033493-kslzdy8q	138	25	bases	basis	NNS
cord-033493-kslzdy8q	138	26	derived	derive	VBN
cord-033493-kslzdy8q	138	27	from	from	IN
cord-033493-kslzdy8q	138	28	5-amino-3-(arylamino)-1H	5-amino-3-(arylamino)-1h	CD
cord-033493-kslzdy8q	138	29	-	-	HYPH
cord-033493-kslzdy8q	138	30	pyrazole-4-carboxamides	pyrazole-4-carboxamides	NNP
cord-033493-kslzdy8q	138	31	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	138	32	and	and	CC
cord-033493-kslzdy8q	138	33	in	in	IN
cord-033493-kslzdy8q	138	34	vitro	vitro	FW
cord-033493-kslzdy8q	138	35	anticancer	anticancer	JJ
cord-033493-kslzdy8q	138	36	activity	activity	NN
cord-033493-kslzdy8q	138	37	of	of	IN
cord-033493-kslzdy8q	138	38	pyrazolo	pyrazolo	NNP
cord-033493-kslzdy8q	138	39	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	138	40	of	of	IN
cord-033493-kslzdy8q	138	41	structurally	structurally	RB
cord-033493-kslzdy8q	138	42	related	relate	VBN
cord-033493-kslzdy8q	138	43	purines	purine	NNS
cord-033493-kslzdy8q	138	44	:	:	:
cord-033493-kslzdy8q	138	45	Benzimidazo[1,2-a]pyridines	benzimidazo[1,2-a]pyridine	NNS
cord-033493-kslzdy8q	138	46	,	,	,
cord-033493-kslzdy8q	138	47	benzimidazo-[1,2-c]-pyrimidines	benzimidazo-[1,2-c]-pyrimidines	CD
cord-033493-kslzdy8q	138	48	,	,	,
cord-033493-kslzdy8q	138	49	and	and	CC
cord-033493-kslzdy8q	138	50	pyrazolo-[1,5-a]pyrimidines	pyrazolo-[1,5-a]pyrimidines	NNP
cord-033493-kslzdy8q	138	51	1,2,3,4-Tetrahydrobenzimidazo[2,1-b]-quinazoline	1,2,3,4-tetrahydrobenzimidazo[2,1-b]-quinazoline	CD
cord-033493-kslzdy8q	138	52	1,2-Dimethylpyrido[1,2-a]benzimidazole-4-carbonitrile	1,2-dimethylpyrido[1,2-a]benzimidazole-4-carbonitrile	CD
cord-033493-kslzdy8q	139	1	Antimetabolites	Antimetabolites	NNPS
cord-033493-kslzdy8q	139	2	:	:	:
cord-033493-kslzdy8q	140	1	A	a	DT
cord-033493-kslzdy8q	140	2	novel	novel	JJ
cord-033493-kslzdy8q	140	3	synthesis	synthesis	NN
cord-033493-kslzdy8q	140	4	of	of	IN
cord-033493-kslzdy8q	140	5	nonclassical	nonclassical	JJ
cord-033493-kslzdy8q	140	6	condensed	condense	VBN
cord-033493-kslzdy8q	140	7	carbocyclic	carbocyclic	JJ
cord-033493-kslzdy8q	140	8	purine	purine	NNP
cord-033493-kslzdy8q	140	9	analogues	analogue	NNS
cord-033493-kslzdy8q	140	10	.	.	.
cord-033493-kslzdy8q	141	1	Egypt	Egypt	NNP
cord-033493-kslzdy8q	141	2	Novel	Novel	NNP
cord-033493-kslzdy8q	141	3	purine	purine	NN
cord-033493-kslzdy8q	141	4	thioglycoside	thioglycoside	IN
cord-033493-kslzdy8q	141	5	analogs	analog	NNS
cord-033493-kslzdy8q	141	6	:	:	:
cord-033493-kslzdy8q	142	1	Synthesis	synthesis	NN
cord-033493-kslzdy8q	142	2	,	,	,
cord-033493-kslzdy8q	142	3	nanoformulation	nanoformulation	NN
cord-033493-kslzdy8q	142	4	and	and	CC
cord-033493-kslzdy8q	142	5	biological	biological	JJ
cord-033493-kslzdy8q	142	6	evaluation	evaluation	NN
cord-033493-kslzdy8q	142	7	in	in	IN
cord-033493-kslzdy8q	142	8	in	in	FW
cord-033493-kslzdy8q	142	9	vitro	vitro	FW
cord-033493-kslzdy8q	142	10	human	human	JJ
cord-033493-kslzdy8q	142	11	liver	liver	NN
cord-033493-kslzdy8q	142	12	and	and	CC
cord-033493-kslzdy8q	142	13	breast	breast	NN
cord-033493-kslzdy8q	142	14	cancer	cancer	NN
cord-033493-kslzdy8q	142	15	models	model	NNS
cord-033493-kslzdy8q	143	1	Antimetabolites	Antimetabolites	NNPS
cord-033493-kslzdy8q	143	2	:	:	:
cord-033493-kslzdy8q	143	3	Design	design	NN
cord-033493-kslzdy8q	143	4	,	,	,
cord-033493-kslzdy8q	143	5	synthesis	synthesis	NN
cord-033493-kslzdy8q	143	6	,	,	,
cord-033493-kslzdy8q	143	7	and	and	CC
cord-033493-kslzdy8q	143	8	cytotoxic	cytotoxic	JJ
cord-033493-kslzdy8q	143	9	evaluation	evaluation	NN
cord-033493-kslzdy8q	143	10	of	of	IN
cord-033493-kslzdy8q	143	11	novel	novel	NNP
cord-033493-kslzdy8q	143	12	dihydropyridine	dihydropyridine	NNP
cord-033493-kslzdy8q	143	13	thioglycosides	thioglycosides	NNP
cord-033493-kslzdy8q	143	14	and	and	CC
cord-033493-kslzdy8q	143	15	pyridine	pyridine	NNP
cord-033493-kslzdy8q	143	16	thioglycosides	thioglycosides	NNP
cord-033493-kslzdy8q	143	17	Crystal	Crystal	NNP
cord-033493-kslzdy8q	143	18	structure	structure	NN
cord-033493-kslzdy8q	143	19	of	of	IN
cord-033493-kslzdy8q	143	20	1-amino-2-oxo-2,5,6,7,8,9-hexahydro-1H	1-amino-2-oxo-2,5,6,7,8,9-hexahydro-1h	CD
cord-033493-kslzdy8q	143	21	-	-	HYPH
cord-033493-kslzdy8q	143	22	cyclohepta	cyclohepta	NN
cord-033493-kslzdy8q	143	23	New	new	JJ
cord-033493-kslzdy8q	143	24	synthetic	synthetic	JJ
cord-033493-kslzdy8q	143	25	strategies	strategy	NNS
cord-033493-kslzdy8q	143	26	for	for	IN
cord-033493-kslzdy8q	143	27	acyclic	acyclic	JJ
cord-033493-kslzdy8q	143	28	and	and	CC
cord-033493-kslzdy8q	143	29	cyclic	cyclic	JJ
cord-033493-kslzdy8q	143	30	pyrimidinethione	pyrimidinethione	NNP
cord-033493-kslzdy8q	143	31	nucleosides	nucleoside	NNS
cord-033493-kslzdy8q	143	32	and	and	CC
cord-033493-kslzdy8q	143	33	their	-PRON-	PRP$
cord-033493-kslzdy8q	143	34	analogues	analogue	NNS
cord-033493-kslzdy8q	143	35	Design	Design	NNP
cord-033493-kslzdy8q	143	36	,	,	,
cord-033493-kslzdy8q	143	37	synthesis	synthesis	NN
cord-033493-kslzdy8q	143	38	,	,	,
cord-033493-kslzdy8q	143	39	molecular	molecular	JJ
cord-033493-kslzdy8q	143	40	docking	docking	NN
cord-033493-kslzdy8q	143	41	and	and	CC
cord-033493-kslzdy8q	143	42	anti	anti	JJ
cord-033493-kslzdy8q	143	43	-	-	JJ
cord-033493-kslzdy8q	143	44	hepatocellular	hepatocellular	JJ
cord-033493-kslzdy8q	143	45	carcinoma	carcinoma	NN
cord-033493-kslzdy8q	143	46	evaluation	evaluation	NN
cord-033493-kslzdy8q	143	47	of	of	IN
cord-033493-kslzdy8q	143	48	novel	novel	JJ
cord-033493-kslzdy8q	143	49	acyclic	acyclic	NNP
cord-033493-kslzdy8q	143	50	pyridine	pyridine	NN
cord-033493-kslzdy8q	143	51	thioglycosides	thioglycosides	NNP
cord-033493-kslzdy8q	144	1	A	a	DT
cord-033493-kslzdy8q	144	2	direct	direct	JJ
cord-033493-kslzdy8q	144	3	route	route	NN
cord-033493-kslzdy8q	144	4	to	to	IN
cord-033493-kslzdy8q	144	5	a	a	DT
cord-033493-kslzdy8q	144	6	new	new	JJ
cord-033493-kslzdy8q	144	7	class	class	NN
cord-033493-kslzdy8q	144	8	of	of	IN
cord-033493-kslzdy8q	144	9	acrylamide	acrylamide	NN
cord-033493-kslzdy8q	144	10	thioglycosides	thioglycosides	NNP
cord-033493-kslzdy8q	144	11	Rapid	Rapid	NNP
cord-033493-kslzdy8q	144	12	colorimetric	colorimetric	JJ
cord-033493-kslzdy8q	144	13	assay	assay	NN
cord-033493-kslzdy8q	144	14	for	for	IN
cord-033493-kslzdy8q	144	15	cellular	cellular	JJ
cord-033493-kslzdy8q	144	16	growth	growth	NN
cord-033493-kslzdy8q	144	17	and	and	CC
cord-033493-kslzdy8q	144	18	survival	survival	NN
cord-033493-kslzdy8q	144	19	:	:	:
cord-033493-kslzdy8q	144	20	Application	application	NN
cord-033493-kslzdy8q	144	21	to	to	IN
cord-033493-kslzdy8q	144	22	proliferation	proliferation	NN
cord-033493-kslzdy8q	144	23	and	and	CC
cord-033493-kslzdy8q	144	24	cytotoxicity	cytotoxicity	NN
cord-033493-kslzdy8q	144	25	assays	assay	NNS
cord-033493-kslzdy8q	144	26	Plaque	Plaque	NNP
cord-033493-kslzdy8q	144	27	inhibition	inhibition	NN
cord-033493-kslzdy8q	144	28	assay	assay	NN
cord-033493-kslzdy8q	144	29	for	for	IN
cord-033493-kslzdy8q	144	30	drug	drug	NN
cord-033493-kslzdy8q	144	31	susceptibility	susceptibility	NN
cord-033493-kslzdy8q	144	32	testing	testing	NN
cord-033493-kslzdy8q	144	33	of	of	IN
cord-033493-kslzdy8q	144	34	influenza	influenza	NN
cord-033493-kslzdy8q	144	35	viruses	virus	NNS
cord-033493-kslzdy8q	144	36	Synthesis	synthesis	NN
cord-033493-kslzdy8q	144	37	and	and	CC
cord-033493-kslzdy8q	144	38	screening	screening	NN
cord-033493-kslzdy8q	144	39	of	of	IN
cord-033493-kslzdy8q	144	40	some	some	DT
cord-033493-kslzdy8q	144	41	novel	novel	NN
cord-033493-kslzdy8q	144	42	fused	fuse	VBN
cord-033493-kslzdy8q	144	43	thiophene	thiophene	NNP
cord-033493-kslzdy8q	144	44	and	and	CC
cord-033493-kslzdy8q	144	45	thienopyrimidine	thienopyrimidine	JJ
cord-033493-kslzdy8q	144	46	derivatives	derivative	NNS
cord-033493-kslzdy8q	144	47	for	for	IN
cord-033493-kslzdy8q	144	48	anti	anti	JJ
cord-033493-kslzdy8q	144	49	-	-	JJ
cord-033493-kslzdy8q	144	50	avian	avian	JJ
cord-033493-kslzdy8q	144	51	influenza	influenza	NN
cord-033493-kslzdy8q	144	52	virus	virus	NN
cord-033493-kslzdy8q	144	53	(	(	-LRB-
cord-033493-kslzdy8q	144	54	H5N1	H5N1	NNP
cord-033493-kslzdy8q	144	55	)	)	-RRB-
cord-033493-kslzdy8q	144	56	activity	activity	NN
cord-033493-kslzdy8q	144	57	Synthesis	Synthesis	NNP
cord-033493-kslzdy8q	144	58	and	and	CC
cord-033493-kslzdy8q	144	59	anti	anti	JJ
cord-033493-kslzdy8q	144	60	-	-	JJ
cord-033493-kslzdy8q	144	61	proliferative	proliferative	JJ
cord-033493-kslzdy8q	144	62	activity	activity	NN
cord-033493-kslzdy8q	144	63	of	of	IN
cord-033493-kslzdy8q	144	64	novel	novel	NN
cord-033493-kslzdy8q	144	65	oxepin	oxepin	NNP
cord-033493-kslzdy8q	144	66	-	-	HYPH
cord-033493-kslzdy8q	144	67	annulated	annulate	VBN
cord-033493-kslzdy8q	144	68	coumarins	coumarins	NNP
cord-033493-kslzdy8q	144	69	Protocols	protocol	NNS
cord-033493-kslzdy8q	144	70	for	for	IN
cord-033493-kslzdy8q	144	71	screening	screen	VBG
cord-033493-kslzdy8q	144	72	chemical	chemical	JJ
cord-033493-kslzdy8q	144	73	agents	agent	NNS
cord-033493-kslzdy8q	144	74	and	and	CC
cord-033493-kslzdy8q	144	75	natural	natural	JJ
cord-033493-kslzdy8q	144	76	products	product	NNS
cord-033493-kslzdy8q	144	77	against	against	IN
cord-033493-kslzdy8q	144	78	animal	animal	NN
cord-033493-kslzdy8q	144	79	tumors	tumor	NNS
cord-033493-kslzdy8q	144	80	and	and	CC
cord-033493-kslzdy8q	144	81	other	other	JJ
cord-033493-kslzdy8q	144	82	biological	biological	JJ
cord-033493-kslzdy8q	144	83	systems	system	NNS
cord-033493-kslzdy8q	144	84	Toward	toward	IN
cord-033493-kslzdy8q	144	85	developing	develop	VBG
cord-033493-kslzdy8q	144	86	therapies	therapy	NNS
cord-033493-kslzdy8q	144	87	against	against	IN
cord-033493-kslzdy8q	144	88	corona	corona	NN
cord-033493-kslzdy8q	144	89	virus	virus	NN
cord-033493-kslzdy8q	144	90	:	:	:
cord-033493-kslzdy8q	144	91	synthesis	synthesis	NN
cord-033493-kslzdy8q	144	92	and	and	CC
cord-033493-kslzdy8q	144	93	anti	anti	JJ
cord-033493-kslzdy8q	144	94	-	-	JJ
cord-033493-kslzdy8q	144	95	avian	avian	JJ
cord-033493-kslzdy8q	144	96	influenza	influenza	NN
cord-033493-kslzdy8q	144	97	virus	virus	NN
cord-033493-kslzdy8q	144	98	activity	activity	NN
cord-033493-kslzdy8q	144	99	of	of	IN
cord-033493-kslzdy8q	144	100	novel	novel	NN
cord-033493-kslzdy8q	144	101	cytosine	cytosine	NN
cord-033493-kslzdy8q	144	102	thioglycoside	thioglycoside	NNP
cord-033493-kslzdy8q	144	103	analogues	analogue	NNS