id author title date pages extension mime words sentences flesch summary cache txt cord-337100-45qr0sak Ferrari, A. Reproducing SARS-CoV-2 epidemics byregion-specific variables and modeling contacttracing App containment 2020-05-19 .txt text/plain 4710 194 43 We built an expanded SIR model of COVID-19 epidemics that accounts for region-specific population densities, and we used it to test the impact of a contact-tracing app in a number of scenarios. Our results show that, in support of efficient isolation of symptomatic cases, app-mediated contact-tracing can improve containment and achieve successful epidemic mitigation even with relatively small fraction of the population using it, and, with increasing penetrance of its adoption, suppression. In this proof-of-concept study we built a comprehensive framework to model the COVID-19 epidemic, taking into account population density, the different contributions of symptomatic, pre-symptomatic and asymptomatic contagions, and we used it to test the efficacy of targeted intervention such as the aforementioned contact tracing app. We built an improved Susceptible-Infectious-Recovered (SIR) model with the aims of a) faithfully reproducing the dynamics of the SARS-CoV-2 epidemics, including the respective roles of asymptomatic infection and population density; b) test the effects of specific interventions, and specifically the use of phone apps for contact tracing. ./cache/cord-337100-45qr0sak.txt ./txt/cord-337100-45qr0sak.txt