id author title date pages extension mime words sentences flesch summary cache txt cord-341639-a8ig607t Hellewell, Joel Feasibility of controlling 2019-nCoV outbreaks by isolation of cases and contacts 2020-02-11 .txt text/plain 4573 252 50 We considered scenarios that varied in: the number of initial cases; the basic reproduction number R0; the delay from symptom onset to isolation; the probability contacts were traced; the proportion of transmission that occurred before symptom onset, and the proportion of subclinical infections. For higher values of R0 and a large initial number of cases, contact tracing and isolation was only potentially feasible when less than 1% of transmission occurred before symptom onset. For example, the severe acute respiratory syndrome (SARS) outbreak that began in Southern China in 2003 was amenable to eventual control through tracing contacts of suspected cases and isolating confirmed cases because the majority of transmission occurred after symptom onset 7 . Figure 4 : The percentage of outbreaks controlled for the baseline scenario (black), and varied number of initial cases (A), time from onset to isolation (B), percentage of transmission before symptoms (C), and proportion of subclinical (asymptomatic) cases (D). ./cache/cord-341639-a8ig607t.txt ./txt/cord-341639-a8ig607t.txt