id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329276-tfrjw743	Ledzewicz, Urszula	On the Role of the Objective in the Optimization of Compartmental Models for Biomedical Therapies	2020-09-30		.txt	text/plain	12517	624	51	We discuss various aspects of the modeling of the dynamics (such as growth and interaction terms), modeling of treatment (including pharmacometrics of the drugs), and give special attention to the choice of the objective functional to be minimized. , m, represent the administration of the therapies (dose rates) and as variables are separated from the effects of the actions (which, for example, depend on the concentrations), then a model which is linear in the controls is not only adequate, but is the correct one. Choosing the objective functional in the form (17) with N = 0 (as we do not consider an immune boost), optimal chemotherapy protocols follow the concatenation structure 1s01 with 1 representing a full dose segment, s denoting administration following a singular control and 0 standing for a rest-period of the treatment.	./cache/cord-329276-tfrjw743.txt	./txt/cord-329276-tfrjw743.txt