id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032831-mupxzffk	Diehl, J.-L.	Physiological effects of adding ECCO(2)R to invasive mechanical ventilation for COPD exacerbations	2020-09-29		.txt	text/plain	5065	278	51	We aimed to evaluate in such patients the effects of a low-to-middle extracorporeal blood flow device on both gas exchanges and dynamic hyperinflation, as well as on work of breathing (WOB) during the IMV weaning process. In the present study, we hypothesized that the addition of ECCO 2 R at the early phase of IMV could both improve gas exchanges and could also permit to diminish respiratory rate (RR), therefore, minimizing dynamic hyperinflation in AE-COPD patients. Accordingly, there was a decrease in native lungs' CO 2 elimination, which, in conjunction with RR adjustment, permitted to improve arterial pH and to obtain a median absolute decrease in PaCO 2 of 19 mmHg. This could be beneficial at the early stage of IMV in AE COPD patients, mainly by minimizing the deleterious effects of acute hypercapnia on ventilator demands, therefore, allowing to shorten deep sedation periods and to rapidly initiate the IMV weaning process.	./cache/cord-032831-mupxzffk.txt	./txt/cord-032831-mupxzffk.txt