id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253564-3y1wdepc	Traves, Suzanne L	Viral-associated exacerbations of asthma and COPD	2007-03-21		.txt	text/plain	3866	212	38	HRV infection of cultured human airway epithelial cells results in production of several pro-inflammatory cytokines and chemokines, including interleukin (IL)-1, IL-6, IL-8, interferon (IFN)-inducible protein of 10 kDa (IP-10), regulated on activation normal T-cell expressed (RANTES), granulocyte macrophage-colony stimulating factor and eotaxin [24] [25] [26] . Despite the potential for epithelial chemokines to recruit multiple cell types to the airways, experimental HRV infections and viral exacerbations of asthma and COPD are dominantly associated with selective recruitment of neutrophils and lymphocytes [4] . Nitric oxide (NO) also appears to be an important component of the host antiviral response because it exerts direct antiviral activity against several viruses associated with exacerbations of asthma and COPD, and also inhibits the viral-induced generation of several cytokines/chemokines from epithelial cells [42] . If the assumption that an over-exuberant host inflammatory response to viral infection plays a key role in disease exacerbation is valid, several potential therapeutic approaches can be suggested.	./cache/cord-253564-3y1wdepc.txt	./txt/cord-253564-3y1wdepc.txt