id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290674-1kdc6xk8	Hershenson, Marc B.	Rhinovirus-Induced Exacerbations of Asthma and COPD	2013-02-21		.txt	text/plain	6746	395	39	Over the past two decades, increasing evidence has shown that, in patients with chronic airways disease, viral infection is the most common cause of exacerbation. Exacerbations due to rhinovirus, which infects relatively few cells in the airway and does not cause the cytotoxicity of other viruses such as influenza or respiratory syncytial virus, are particularly poorly understood. PCR-based studies examining the prevalence of virus identification among various cohorts of patients with chronic airways disease consistently show a higher prevalence of viral infection during exacerbations. (Nevertheless, the amount of viral replication in the airways remains uncertain.) Also, patients with asthma who had an exacerbation following experimental infection had higher levels of viral RNA in their sputum compared to asthmatics that did not experience an exacerbation, further evidence that viruses do indeed cause exacerbations. Also following experimental rhinovirus infection, viral clearance and airway function correlate with blood and bronchoalveolar (BAL) CD4 cell interferon gamma production [63] .	./cache/cord-290674-1kdc6xk8.txt	./txt/cord-290674-1kdc6xk8.txt