id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291639-hioh2s35	Alfredo, Potena	Pathophysiology of viral-induced exacerbations of COPD	2007-12-17		.txt	text/plain	4434	205	34	Many epidemiological and clinical studies have suggested a role for respiratory viral infections in the natural history of chronic obstructive pulmonary disease (COPD), particularly during their exacerbations highlighting the need for development of effective vaccines and/or treatment for these viruses. In this review we will provide an overview of the relationship between respiratory virus infection and the molecular mechanisms involved in the activation of airway infl ammation in COPD exacerbations. It has been postulated that bacterial colonization could contribute to increased susceptibility to viral infection in COPD patients for example by increasing ICAM-1 expression in bronchial epithelial cells either directly or through induced infl ammation (Sajjan et al 2006) . Despite growing clinical evidence for a role of respiratory viral infections in the pathogenesis of COPD exacerbations, the precise mechanisms of respiratory virus-induced airway infl ammation and of host defenses against respiratory viruses are poorly understood (Johnston 2005) .	./cache/cord-291639-hioh2s35.txt	./txt/cord-291639-hioh2s35.txt