id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331895-3srslmgk	Jacobs, M.	Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects	2020-06-02		.txt	text/plain	4897	281	53	Objectives: We investigated the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry receptor ACE2 and the protease TMPRSS2 in lung tissue from never smokers and smokers with and without COPD. Results: ACE2 mRNA expression was significantly higher in lung tissue from current smokers and subjects with moderate to very severe COPD and correlated with physiological parameters of airway obstruction and emphysema. . https://doi.org/10.1101/2020.05.27.20114298 doi: medRxiv preprint ACE2 protein levels are increased in alveolar tissue and bronchial epithelium of smokers and COPD subjects. We clearly demonstrate an increased pulmonary expression of the SARS-CoV-2 entry receptor ACE2 in smokers and COPD subjects at both mRNA and protein level, by RT-PCR and immunohistochemistry respectively. . https://doi.org/10.1101/2020.05.27.20114298 doi: medRxiv preprint By quantification of the ACE2 IHC staining, we demonstrate increased protein levels of ACE2 in both alveolar and bronchial epithelium of current smokers and patients with moderate and (very) severe COPD.	./cache/cord-331895-3srslmgk.txt	./txt/cord-331895-3srslmgk.txt