id author title date pages extension mime words sentences flesch summary cache txt cord-340420-ws3qesns Sin, Don D. COVID-19 in COPD: A growing concern 2020-09-19 .txt text/plain 866 50 44 As of August 24, 2020, over 23 million people around the world have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic [1] . There is considerable debate on whether (or not) chronic obstructive pulmonary disease (COPD), a common airway disease that affects 10% of individuals over 45 years of age [3] , is a risk factor for COVID-19. Together, these data suggest that COPD is a risk factor for severe COVID-19 that leads to hospitalization and ICU admission. Another possibility is that patients with COPD often demonstrate perturbations in the renin-angiotensin-aldosterone system with up-regulation of ACE and angiotensin II [9] that may be exacerbated during acute SARS-CoV-2 infection, leading to acute pulmonary hypertension and pulmonary edema. SARS-CoV-2 infection in the COPD population is associated with increased healthcare utilization: an analysis of Cleveland Clinic's COVID-19 Registry ./cache/cord-340420-ws3qesns.txt ./txt/cord-340420-ws3qesns.txt