id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354040-7ylp7edo	Maremanda, Krishna P.	Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis	2020-06-15		.txt	text/plain	6189	317	57	Several genes were differentially expressed in younger and older smokers, and patients with COPD and IPF compared to non-smokers which were part of the mitochondrial biogenesis/function (HSPD1, FEN1, COX18, COX10, UCP2 & 3), cellular senescence (PCNA, PTEN, KLOTHO, CDKN1C, TNKS2, NFATC1 & 2, GADD45A) and telomere replication/maintenance (PARP1, SIRT6, NBN, TERT, RAD17, SLX4, HAT1) target genes. Overall, these findings suggest that altered transcription of target genes that regulate mitochondrial function, cellular senescence, and telomere attrition add to the pathobiology of lung aging in COPD and IPF and other smoking-related chronic lung disease in associated with alterations in SARS-CoV-2 ACE2-TMPRSS2-Furin-DPP4 axis for COVID-19 infection. Cigarette smoke alters several key functions in the cells, among them the crucial genes related to mitochondrial function, cellular senescence and telomeric length were selected in the current study to observe for any differential changes among young and old age groups categorized as non-smokers, smokers and COPD groups.	./cache/cord-354040-7ylp7edo.txt	./txt/cord-354040-7ylp7edo.txt