id	sid	tid	token	lemma	pos
cord-007444-c9vu8ako	1	1	key	key	JJ
cord-007444-c9vu8ako	1	2	:	:	:
cord-007444-c9vu8ako	1	3	cord-007444-c9vu8ako	cord-007444-c9vu8ako	NN
cord-007444-c9vu8ako	1	4	authors	author	NNS
cord-007444-c9vu8ako	1	5	:	:	:
cord-007444-c9vu8ako	1	6	Sherk	Sherk	NNP
cord-007444-c9vu8ako	1	7	,	,	,
cord-007444-c9vu8ako	1	8	Peter	Peter	NNP
cord-007444-c9vu8ako	1	9	A.	A.	NNP
cord-007444-c9vu8ako	1	10	;	;	:
cord-007444-c9vu8ako	1	11	Grossman	Grossman	NNP
cord-007444-c9vu8ako	1	12	,	,	,
cord-007444-c9vu8ako	1	13	Ronald	Ronald	NNP
cord-007444-c9vu8ako	1	14	F.	F.	NNP
cord-007444-c9vu8ako	1	15	title	title	NN
cord-007444-c9vu8ako	1	16	:	:	:
cord-007444-c9vu8ako	1	17	The	the	DT
cord-007444-c9vu8ako	1	18	Chronic	Chronic	NNP
cord-007444-c9vu8ako	1	19	Obstructive	obstructive	JJ
cord-007444-c9vu8ako	1	20	Pulmonary	Pulmonary	NNP
cord-007444-c9vu8ako	1	21	Disease	Disease	NNP
cord-007444-c9vu8ako	1	22	Exacerbation	Exacerbation	NNP
cord-007444-c9vu8ako	1	23	date	date	NN
cord-007444-c9vu8ako	1	24	:	:	:
cord-007444-c9vu8ako	1	25	2000	2000	CD
cord-007444-c9vu8ako	1	26	-	-	SYM
cord-007444-c9vu8ako	1	27	12	12	CD
cord-007444-c9vu8ako	1	28	-	-	HYPH
cord-007444-c9vu8ako	1	29	01	01	CD
cord-007444-c9vu8ako	1	30	journal	journal	NN
cord-007444-c9vu8ako	1	31	:	:	:
cord-007444-c9vu8ako	1	32	Clin	Clin	NNP
cord-007444-c9vu8ako	1	33	Chest	Chest	NNP
cord-007444-c9vu8ako	1	34	Med	Med	NNP
cord-007444-c9vu8ako	1	35	DOI	doi	NN
cord-007444-c9vu8ako	1	36	:	:	:
cord-007444-c9vu8ako	1	37	10.1016	10.1016	CD
cord-007444-c9vu8ako	1	38	/	/	SYM
cord-007444-c9vu8ako	1	39	s0272	s0272	NNP
cord-007444-c9vu8ako	1	40	-	-	HYPH
cord-007444-c9vu8ako	1	41	5231(05)70179	5231(05)70179	NNP
cord-007444-c9vu8ako	1	42	-	-	SYM
cord-007444-c9vu8ako	1	43	9	9	CD
cord-007444-c9vu8ako	1	44	sha	sha	NN
cord-007444-c9vu8ako	1	45	:	:	:
cord-007444-c9vu8ako	1	46	2c9475aa7971ae4c5ae18329ae9895b2c1b8bbe7	2c9475aa7971ae4c5ae18329ae9895b2c1b8bbe7	CD
cord-007444-c9vu8ako	1	47	doc_id	doc_id	CD
cord-007444-c9vu8ako	1	48	:	:	:
cord-007444-c9vu8ako	1	49	7444	7444	CD
cord-007444-c9vu8ako	1	50	cord_uid	cord_uid	NNS
cord-007444-c9vu8ako	1	51	:	:	:
cord-007444-c9vu8ako	2	1	c9vu8ako	c9vu8ako	.
cord-007444-c9vu8ako	3	1	nan	nan	NNP
cord-007444-c9vu8ako	3	2	Peter	Peter	NNP
cord-007444-c9vu8ako	3	3	A.	a.	NN
cord-007444-c9vu8ako	3	4	Sherk	Sherk	NNP
cord-007444-c9vu8ako	3	5	,	,	,
cord-007444-c9vu8ako	3	6	MD	MD	NNP
cord-007444-c9vu8ako	3	7	,	,	,
cord-007444-c9vu8ako	3	8	and	and	CC
cord-007444-c9vu8ako	3	9	Ronald	Ronald	NNP
cord-007444-c9vu8ako	3	10	F.	F.	NNP
cord-007444-c9vu8ako	3	11	Grossman	Grossman	NNP
cord-007444-c9vu8ako	3	12	,	,	,
cord-007444-c9vu8ako	3	13	MD	MD	NNP
cord-007444-c9vu8ako	3	14	,	,	,
cord-007444-c9vu8ako	3	15	FRCPC	FRCPC	NNP
cord-007444-c9vu8ako	3	16	Chronic	Chronic	NNP
cord-007444-c9vu8ako	3	17	obstructive	obstructive	JJ
cord-007444-c9vu8ako	3	18	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	3	19	disease	disease	NN
cord-007444-c9vu8ako	3	20	(	(	-LRB-
cord-007444-c9vu8ako	3	21	COPD	COPD	NNP
cord-007444-c9vu8ako	3	22	)	)	-RRB-
cord-007444-c9vu8ako	3	23	is	be	VBZ
cord-007444-c9vu8ako	3	24	characterized	characterize	VBN
cord-007444-c9vu8ako	3	25	by	by	IN
cord-007444-c9vu8ako	3	26	the	the	DT
cord-007444-c9vu8ako	3	27	presence	presence	NN
cord-007444-c9vu8ako	3	28	of	of	IN
cord-007444-c9vu8ako	3	29	airflow	airflow	NNP
cord-007444-c9vu8ako	3	30	obstruction	obstruction	NN
cord-007444-c9vu8ako	3	31	caused	cause	VBN
cord-007444-c9vu8ako	3	32	by	by	IN
cord-007444-c9vu8ako	3	33	chronic	chronic	JJ
cord-007444-c9vu8ako	3	34	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	3	35	or	or	CC
cord-007444-c9vu8ako	3	36	emphysema	emphysema	NN
cord-007444-c9vu8ako	3	37	.	.	.
cord-007444-c9vu8ako	4	1	This	this	DT
cord-007444-c9vu8ako	4	2	airflow	airflow	NN
cord-007444-c9vu8ako	4	3	obstruction	obstruction	NN
cord-007444-c9vu8ako	4	4	is	be	VBZ
cord-007444-c9vu8ako	4	5	generally	generally	RB
cord-007444-c9vu8ako	4	6	progressive	progressive	JJ
cord-007444-c9vu8ako	4	7	,	,	,
cord-007444-c9vu8ako	4	8	may	may	MD
cord-007444-c9vu8ako	4	9	be	be	VB
cord-007444-c9vu8ako	4	10	accompanied	accompany	VBN
cord-007444-c9vu8ako	4	11	by	by	IN
cord-007444-c9vu8ako	4	12	airway	airway	NNP
cord-007444-c9vu8ako	4	13	hyperreactivity	hyperreactivity	NNP
cord-007444-c9vu8ako	4	14	,	,	,
cord-007444-c9vu8ako	4	15	and	and	CC
cord-007444-c9vu8ako	4	16	often	often	RB
cord-007444-c9vu8ako	4	17	is	be	VBZ
cord-007444-c9vu8ako	4	18	partially	partially	RB
cord-007444-c9vu8ako	4	19	re	re	VBN
cord-007444-c9vu8ako	5	1	~ersible.~	~ersible.~	XX
cord-007444-c9vu8ako	5	2	Declining	decline	VBG
cord-007444-c9vu8ako	5	3	lung	lung	NN
cord-007444-c9vu8ako	5	4	function	function	NN
cord-007444-c9vu8ako	5	5	is	be	VBZ
cord-007444-c9vu8ako	5	6	almost	almost	RB
cord-007444-c9vu8ako	5	7	universally	universally	RB
cord-007444-c9vu8ako	5	8	caused	cause	VBN
cord-007444-c9vu8ako	5	9	by	by	IN
cord-007444-c9vu8ako	5	10	decades	decade	NNS
cord-007444-c9vu8ako	5	11	of	of	IN
cord-007444-c9vu8ako	5	12	tobacco	tobacco	NN
cord-007444-c9vu8ako	5	13	smoke	smoke	NN
cord-007444-c9vu8ako	5	14	exposure	exposure	NN
cord-007444-c9vu8ako	5	15	and	and	CC
cord-007444-c9vu8ako	5	16	develops	develop	VBZ
cord-007444-c9vu8ako	5	17	insidiously	insidiously	RB
cord-007444-c9vu8ako	5	18	so	so	IN
cord-007444-c9vu8ako	5	19	that	that	IN
cord-007444-c9vu8ako	5	20	patients	patient	NNS
cord-007444-c9vu8ako	5	21	often	often	RB
cord-007444-c9vu8ako	5	22	do	do	VBP
cord-007444-c9vu8ako	5	23	not	not	RB
cord-007444-c9vu8ako	5	24	complain	complain	VB
cord-007444-c9vu8ako	5	25	of	of	IN
cord-007444-c9vu8ako	5	26	exertional	exertional	JJ
cord-007444-c9vu8ako	5	27	dyspnea	dyspnea	NN
cord-007444-c9vu8ako	5	28	until	until	IN
cord-007444-c9vu8ako	5	29	their	-PRON-	PRP$
cord-007444-c9vu8ako	5	30	1-second	1-second	CD
cord-007444-c9vu8ako	5	31	forced	force	VBN
cord-007444-c9vu8ako	5	32	expiratory	expiratory	JJ
cord-007444-c9vu8ako	5	33	volume	volume	NN
cord-007444-c9vu8ako	5	34	(	(	-LRB-
cord-007444-c9vu8ako	5	35	FEV	FEV	NNP
cord-007444-c9vu8ako	5	36	,	,	,
cord-007444-c9vu8ako	5	37	)	)	-RRB-
cord-007444-c9vu8ako	5	38	is	be	VBZ
cord-007444-c9vu8ako	5	39	between	between	IN
cord-007444-c9vu8ako	5	40	40	40	CD
cord-007444-c9vu8ako	5	41	%	%	NN
cord-007444-c9vu8ako	5	42	and	and	CC
cord-007444-c9vu8ako	5	43	59	59	CD
cord-007444-c9vu8ako	5	44	%	%	NN
cord-007444-c9vu8ako	5	45	of	of	IN
cord-007444-c9vu8ako	5	46	its	-PRON-	PRP$
cord-007444-c9vu8ako	5	47	predicted	predict	VBN
cord-007444-c9vu8ako	5	48	value.20	value.20	NNP
cord-007444-c9vu8ako	6	1	When	when	WRB
cord-007444-c9vu8ako	6	2	the	the	DT
cord-007444-c9vu8ako	6	3	FEV	FEV	NNP
cord-007444-c9vu8ako	6	4	,	,	,
cord-007444-c9vu8ako	6	5	falls	fall	VBZ
cord-007444-c9vu8ako	6	6	below	below	IN
cord-007444-c9vu8ako	6	7	1	1	CD
cord-007444-c9vu8ako	6	8	L	l	NN
cord-007444-c9vu8ako	6	9	,	,	,
cord-007444-c9vu8ako	6	10	patients	patient	NNS
cord-007444-c9vu8ako	6	11	are	be	VBP
cord-007444-c9vu8ako	6	12	disabled	disabled	JJ
cord-007444-c9vu8ako	6	13	in	in	IN
cord-007444-c9vu8ako	6	14	the	the	DT
cord-007444-c9vu8ako	6	15	activities	activity	NNS
cord-007444-c9vu8ako	6	16	of	of	IN
cord-007444-c9vu8ako	6	17	daily	daily	JJ
cord-007444-c9vu8ako	6	18	living	live	VBG
cord-007444-c9vu8ako	6	19	and	and	CC
cord-007444-c9vu8ako	6	20	have	have	VB
cord-007444-c9vu8ako	6	21	a	a	DT
cord-007444-c9vu8ako	6	22	5-year	5-year	CD
cord-007444-c9vu8ako	6	23	survival	survival	NN
cord-007444-c9vu8ako	6	24	of	of	IN
cord-007444-c9vu8ako	6	25	approximately	approximately	RB
cord-007444-c9vu8ako	6	26	50?!0	50?!0	CD
cord-007444-c9vu8ako	6	27	.	.	.
cord-007444-c9vu8ako	7	1	Forced	force	VBN
cord-007444-c9vu8ako	7	2	expiratory	expiratory	JJ
cord-007444-c9vu8ako	7	3	volume	volume	NN
cord-007444-c9vu8ako	7	4	in	in	IN
cord-007444-c9vu8ako	7	5	1	1	CD
cord-007444-c9vu8ako	7	6	second	second	JJ
cord-007444-c9vu8ako	7	7	declines	decline	NNS
cord-007444-c9vu8ako	7	8	by	by	IN
cord-007444-c9vu8ako	7	9	about	about	RB
cord-007444-c9vu8ako	7	10	30	30	CD
cord-007444-c9vu8ako	7	11	mL	ml	NN
cord-007444-c9vu8ako	7	12	/	/	SYM
cord-007444-c9vu8ako	7	13	year	year	NN
cord-007444-c9vu8ako	7	14	in	in	IN
cord-007444-c9vu8ako	7	15	healthy	healthy	JJ
cord-007444-c9vu8ako	7	16	nonsmokers	nonsmoker	NNS
cord-007444-c9vu8ako	7	17	,	,	,
cord-007444-c9vu8ako	7	18	whereas	whereas	IN
cord-007444-c9vu8ako	7	19	the	the	DT
cord-007444-c9vu8ako	7	20	average	average	JJ
cord-007444-c9vu8ako	7	21	decline	decline	NN
cord-007444-c9vu8ako	7	22	is	be	VBZ
cord-007444-c9vu8ako	7	23	approximately	approximately	RB
cord-007444-c9vu8ako	7	24	45	45	CD
cord-007444-c9vu8ako	7	25	mL	ml	NN
cord-007444-c9vu8ako	7	26	/	/	SYM
cord-007444-c9vu8ako	7	27	year	year	NN
cord-007444-c9vu8ako	7	28	in	in	IN
cord-007444-c9vu8ako	7	29	smokers.20	smokers.20	NN
cord-007444-c9vu8ako	8	1	Approximately	approximately	RB
cord-007444-c9vu8ako	8	2	15	15	CD
cord-007444-c9vu8ako	8	3	%	%	NN
cord-007444-c9vu8ako	8	4	of	of	IN
cord-007444-c9vu8ako	8	5	smokers	smoker	NNS
cord-007444-c9vu8ako	8	6	are	be	VBP
cord-007444-c9vu8ako	8	7	susceptible	susceptible	JJ
cord-007444-c9vu8ako	8	8	to	to	IN
cord-007444-c9vu8ako	8	9	the	the	DT
cord-007444-c9vu8ako	8	10	airway	airway	NN
cord-007444-c9vu8ako	8	11	effects	effect	NNS
cord-007444-c9vu8ako	8	12	of	of	IN
cord-007444-c9vu8ako	8	13	smoking	smoking	NN
cord-007444-c9vu8ako	8	14	and	and	CC
cord-007444-c9vu8ako	8	15	will	will	MD
cord-007444-c9vu8ako	8	16	develop	develop	VB
cord-007444-c9vu8ako	8	17	COPD	COPD	NNP
cord-007444-c9vu8ako	8	18	.	.	.
cord-007444-c9vu8ako	9	1	These	these	DT
cord-007444-c9vu8ako	9	2	patients	patient	NNS
cord-007444-c9vu8ako	9	3	show	show	VBP
cord-007444-c9vu8ako	9	4	accelerated	accelerated	JJ
cord-007444-c9vu8ako	9	5	rates	rate	NNS
cord-007444-c9vu8ako	9	6	of	of	IN
cord-007444-c9vu8ako	9	7	decline	decline	NN
cord-007444-c9vu8ako	9	8	in	in	IN
cord-007444-c9vu8ako	9	9	FEV	FEV	NNP
cord-007444-c9vu8ako	9	10	,	,	,
cord-007444-c9vu8ako	9	11	of	of	IN
cord-007444-c9vu8ako	9	12	between	between	IN
cord-007444-c9vu8ako	9	13	50	50	CD
cord-007444-c9vu8ako	9	14	and	and	CC
cord-007444-c9vu8ako	9	15	90	90	CD
cord-007444-c9vu8ako	9	16	m	m	NN
cord-007444-c9vu8ako	9	17	L	L	NNP
cord-007444-c9vu8ako	9	18	/~e	/~e	NNP
cord-007444-c9vu8ako	9	19	a	a	DT
cord-007444-c9vu8ako	9	20	r	r	NN
cord-007444-c9vu8ako	9	21	.~~	.~~	.
cord-007444-c9vu8ako	10	1	In	in	IN
cord-007444-c9vu8ako	10	2	1994	1994	CD
cord-007444-c9vu8ako	10	3	,	,	,
cord-007444-c9vu8ako	10	4	approximately	approximately	RB
cord-007444-c9vu8ako	10	5	16	16	CD
cord-007444-c9vu8ako	10	6	million	million	CD
cord-007444-c9vu8ako	10	7	Americans	Americans	NNPS
cord-007444-c9vu8ako	10	8	suffered	suffer	VBD
cord-007444-c9vu8ako	10	9	from	from	IN
cord-007444-c9vu8ako	10	10	COPD	COPD	NNP
cord-007444-c9vu8ako	10	11	,	,	,
cord-007444-c9vu8ako	10	12	an	an	DT
cord-007444-c9vu8ako	10	13	estimated	estimate	VBN
cord-007444-c9vu8ako	10	14	increase	increase	NN
cord-007444-c9vu8ako	10	15	of	of	IN
cord-007444-c9vu8ako	10	16	60	60	CD
cord-007444-c9vu8ako	10	17	%	%	NN
cord-007444-c9vu8ako	10	18	since	since	IN
cord-007444-c9vu8ako	10	19	1982.'j	1982.'j	CD
cord-007444-c9vu8ako	10	20	It	-PRON-	PRP
cord-007444-c9vu8ako	10	21	ranks	rank	VBZ
cord-007444-c9vu8ako	10	22	fourth	fourth	RB
cord-007444-c9vu8ako	10	23	among	among	IN
cord-007444-c9vu8ako	10	24	leading	leading	JJ
cord-007444-c9vu8ako	10	25	causes	cause	NNS
cord-007444-c9vu8ako	10	26	of	of	IN
cord-007444-c9vu8ako	10	27	death	death	NN
cord-007444-c9vu8ako	10	28	in	in	IN
cord-007444-c9vu8ako	10	29	North	North	NNP
cord-007444-c9vu8ako	10	30	America	America	NNP
cord-007444-c9vu8ako	10	31	and	and	CC
cord-007444-c9vu8ako	10	32	is	be	VBZ
cord-007444-c9vu8ako	10	33	the	the	DT
cord-007444-c9vu8ako	10	34	only	only	RB
cord-007444-c9vu8ako	10	35	leading	leading	JJ
cord-007444-c9vu8ako	10	36	cause	cause	NN
cord-007444-c9vu8ako	10	37	of	of	IN
cord-007444-c9vu8ako	10	38	death	death	NN
cord-007444-c9vu8ako	10	39	that	that	WDT
cord-007444-c9vu8ako	10	40	is	be	VBZ
cord-007444-c9vu8ako	10	41	rising	rise	VBG
cord-007444-c9vu8ako	10	42	in	in	IN
cord-007444-c9vu8ako	10	43	prevalence	prevalence	NN
cord-007444-c9vu8ako	10	44	.	.	.
cord-007444-c9vu8ako	11	1	'	'	''
cord-007444-c9vu8ako	11	2	j	j	NNP
cord-007444-c9vu8ako	12	1	,	,	,
cord-007444-c9vu8ako	12	2	28	28	CD
cord-007444-c9vu8ako	13	1	According	accord	VBG
cord-007444-c9vu8ako	13	2	to	to	IN
cord-007444-c9vu8ako	13	3	1993	1993	CD
cord-007444-c9vu8ako	13	4	estimates	estimate	NNS
cord-007444-c9vu8ako	13	5	made	make	VBN
cord-007444-c9vu8ako	13	6	by	by	IN
cord-007444-c9vu8ako	13	7	the	the	DT
cord-007444-c9vu8ako	13	8	National	National	NNP
cord-007444-c9vu8ako	13	9	Heart	Heart	NNP
cord-007444-c9vu8ako	13	10	Lung	Lung	NNP
cord-007444-c9vu8ako	13	11	and	and	CC
cord-007444-c9vu8ako	13	12	Blood	Blood	NNP
cord-007444-c9vu8ako	13	13	Institute	Institute	NNP
cord-007444-c9vu8ako	13	14	,	,	,
cord-007444-c9vu8ako	13	15	the	the	DT
cord-007444-c9vu8ako	13	16	annual	annual	JJ
cord-007444-c9vu8ako	13	17	total	total	JJ
cord-007444-c9vu8ako	13	18	cost	cost	NN
cord-007444-c9vu8ako	13	19	arising	arise	VBG
cord-007444-c9vu8ako	13	20	from	from	IN
cord-007444-c9vu8ako	13	21	COPD	COPD	NNP
cord-007444-c9vu8ako	13	22	was	be	VBD
cord-007444-c9vu8ako	13	23	nearly	nearly	RB
cord-007444-c9vu8ako	13	24	$	$	$
cord-007444-c9vu8ako	13	25	24	24	CD
cord-007444-c9vu8ako	13	26	billion	billion	CD
cord-007444-c9vu8ako	13	27	dollars	dollar	NNS
cord-007444-c9vu8ako	13	28	.	.	.
cord-007444-c9vu8ako	14	1	This	this	DT
cord-007444-c9vu8ako	14	2	amount	amount	NN
cord-007444-c9vu8ako	14	3	includes	include	VBZ
cord-007444-c9vu8ako	14	4	almost	almost	RB
cord-007444-c9vu8ako	14	5	$	$	$
cord-007444-c9vu8ako	14	6	15	15	CD
cord-007444-c9vu8ako	14	7	billion	billion	CD
cord-007444-c9vu8ako	14	8	in	in	IN
cord-007444-c9vu8ako	14	9	direct	direct	JJ
cord-007444-c9vu8ako	14	10	health	health	NN
cord-007444-c9vu8ako	14	11	care	care	NN
cord-007444-c9vu8ako	14	12	expenditures	expenditure	NNS
cord-007444-c9vu8ako	14	13	,	,	,
cord-007444-c9vu8ako	14	14	nearly	nearly	RB
cord-007444-c9vu8ako	14	15	$	$	$
cord-007444-c9vu8ako	14	16	5	5	CD
cord-007444-c9vu8ako	14	17	billion	billion	CD
cord-007444-c9vu8ako	14	18	in	in	IN
cord-007444-c9vu8ako	14	19	indirect	indirect	JJ
cord-007444-c9vu8ako	14	20	morbidity	morbidity	NN
cord-007444-c9vu8ako	14	21	costs	cost	NNS
cord-007444-c9vu8ako	14	22	,	,	,
cord-007444-c9vu8ako	14	23	and	and	CC
cord-007444-c9vu8ako	14	24	$	$	$
cord-007444-c9vu8ako	14	25	4.5	4.5	CD
cord-007444-c9vu8ako	14	26	billion	billion	CD
cord-007444-c9vu8ako	14	27	in	in	IN
cord-007444-c9vu8ako	14	28	indirect	indirect	JJ
cord-007444-c9vu8ako	14	29	mortality	mortality	NN
cord-007444-c9vu8ako	14	30	costs	cost	NNS
cord-007444-c9vu8ako	14	31	.	.	.
cord-007444-c9vu8ako	15	1	6	6	CD
cord-007444-c9vu8ako	15	2	Periods	period	NNS
cord-007444-c9vu8ako	15	3	of	of	IN
cord-007444-c9vu8ako	15	4	relative	relative	JJ
cord-007444-c9vu8ako	15	5	clinical	clinical	JJ
cord-007444-c9vu8ako	15	6	stability	stability	NN
cord-007444-c9vu8ako	15	7	during	during	IN
cord-007444-c9vu8ako	15	8	the	the	DT
cord-007444-c9vu8ako	15	9	course	course	NN
cord-007444-c9vu8ako	15	10	of	of	IN
cord-007444-c9vu8ako	15	11	COPD	COPD	NNP
cord-007444-c9vu8ako	15	12	are	be	VBP
cord-007444-c9vu8ako	15	13	interrupted	interrupt	VBN
cord-007444-c9vu8ako	15	14	by	by	IN
cord-007444-c9vu8ako	15	15	recurrent	recurrent	JJ
cord-007444-c9vu8ako	15	16	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	15	17	.	.	.
cord-007444-c9vu8ako	16	1	The	the	DT
cord-007444-c9vu8ako	16	2	definition	definition	NN
cord-007444-c9vu8ako	16	3	of	of	IN
cord-007444-c9vu8ako	16	4	an	an	DT
cord-007444-c9vu8ako	16	5	acute	acute	JJ
cord-007444-c9vu8ako	16	6	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	16	7	of	of	IN
cord-007444-c9vu8ako	16	8	COPD	COPD	NNP
cord-007444-c9vu8ako	16	9	(	(	-LRB-
cord-007444-c9vu8ako	16	10	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	16	11	)	)	-RRB-
cord-007444-c9vu8ako	16	12	is	be	VBZ
cord-007444-c9vu8ako	16	13	imprecise	imprecise	JJ
cord-007444-c9vu8ako	16	14	but	but	CC
cord-007444-c9vu8ako	16	15	is	be	VBZ
cord-007444-c9vu8ako	16	16	generally	generally	RB
cord-007444-c9vu8ako	16	17	considered	consider	VBN
cord-007444-c9vu8ako	16	18	clinically	clinically	RB
cord-007444-c9vu8ako	16	19	as	as	IN
cord-007444-c9vu8ako	16	20	an	an	DT
cord-007444-c9vu8ako	16	21	episode	episode	NN
cord-007444-c9vu8ako	16	22	of	of	IN
cord-007444-c9vu8ako	16	23	increased	increase	VBN
cord-007444-c9vu8ako	16	24	dyspnea	dyspnea	NN
cord-007444-c9vu8ako	16	25	,	,	,
cord-007444-c9vu8ako	16	26	sputum	sputum	NN
cord-007444-c9vu8ako	16	27	production	production	NN
cord-007444-c9vu8ako	16	28	,	,	,
cord-007444-c9vu8ako	16	29	and	and	CC
cord-007444-c9vu8ako	16	30	sputum	sputum	NN
cord-007444-c9vu8ako	16	31	purulence	purulence	NN
cord-007444-c9vu8ako	16	32	in	in	IN
cord-007444-c9vu8ako	16	33	a	a	DT
cord-007444-c9vu8ako	16	34	patient	patient	NN
cord-007444-c9vu8ako	16	35	with	with	IN
cord-007444-c9vu8ako	16	36	COPD	COPD	NNP
cord-007444-c9vu8ako	16	37	.	.	.
cord-007444-c9vu8ako	17	1	"	"	``
cord-007444-c9vu8ako	17	2	When	when	WRB
cord-007444-c9vu8ako	17	3	these	these	DT
cord-007444-c9vu8ako	17	4	symptoms	symptom	NNS
cord-007444-c9vu8ako	17	5	are	be	VBP
cord-007444-c9vu8ako	17	6	severe	severe	JJ
cord-007444-c9vu8ako	17	7	and	and	CC
cord-007444-c9vu8ako	17	8	accompanied	accompany	VBN
cord-007444-c9vu8ako	17	9	by	by	IN
cord-007444-c9vu8ako	17	10	significant	significant	JJ
cord-007444-c9vu8ako	17	11	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	17	12	or	or	CC
cord-007444-c9vu8ako	17	13	hypercapnia	hypercapnia	NN
cord-007444-c9vu8ako	17	14	,	,	,
cord-007444-c9vu8ako	17	15	patients	patient	NNS
cord-007444-c9vu8ako	17	16	may	may	MD
cord-007444-c9vu8ako	17	17	require	require	VB
cord-007444-c9vu8ako	17	18	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	17	19	.	.	.
cord-007444-c9vu8ako	18	1	This	this	DT
cord-007444-c9vu8ako	18	2	article	article	NN
cord-007444-c9vu8ako	18	3	focuses	focus	VBZ
cord-007444-c9vu8ako	18	4	primarily	primarily	RB
cord-007444-c9vu8ako	18	5	on	on	IN
cord-007444-c9vu8ako	18	6	the	the	DT
cord-007444-c9vu8ako	18	7	management	management	NN
cord-007444-c9vu8ako	18	8	of	of	IN
cord-007444-c9vu8ako	18	9	hospitalized	hospitalize	VBN
cord-007444-c9vu8ako	18	10	patients	patient	NNS
cord-007444-c9vu8ako	18	11	with	with	IN
cord-007444-c9vu8ako	18	12	AE	AE	NNP
cord-007444-c9vu8ako	18	13	-	-	HYPH
cord-007444-c9vu8ako	18	14	COPD	COPD	NNP
cord-007444-c9vu8ako	18	15	outside	outside	IN
cord-007444-c9vu8ako	18	16	of	of	IN
cord-007444-c9vu8ako	18	17	the	the	DT
cord-007444-c9vu8ako	18	18	intensive	intensive	JJ
cord-007444-c9vu8ako	18	19	care	care	NN
cord-007444-c9vu8ako	18	20	unit	unit	NN
cord-007444-c9vu8ako	18	21	and	and	CC
cord-007444-c9vu8ako	18	22	reviews	review	VBZ
cord-007444-c9vu8ako	18	23	the	the	DT
cord-007444-c9vu8ako	18	24	evidence	evidence	NN
cord-007444-c9vu8ako	18	25	supporting	support	VBG
cord-007444-c9vu8ako	18	26	the	the	DT
cord-007444-c9vu8ako	18	27	available	available	JJ
cord-007444-c9vu8ako	18	28	therapies	therapy	NNS
cord-007444-c9vu8ako	18	29	for	for	IN
cord-007444-c9vu8ako	18	30	COPD	COPD	NNP
cord-007444-c9vu8ako	18	31	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	18	32	.	.	.
cord-007444-c9vu8ako	19	1	Cigarette	cigarette	NN
cord-007444-c9vu8ako	19	2	smoking	smoking	NN
cord-007444-c9vu8ako	19	3	is	be	VBZ
cord-007444-c9vu8ako	19	4	the	the	DT
cord-007444-c9vu8ako	19	5	most	most	RBS
cord-007444-c9vu8ako	19	6	important	important	JJ
cord-007444-c9vu8ako	19	7	cause	cause	NN
cord-007444-c9vu8ako	19	8	of	of	IN
cord-007444-c9vu8ako	19	9	COPD.lo9	copd.lo9	JJ
cord-007444-c9vu8ako	19	10	Smoking	smoking	NN
cord-007444-c9vu8ako	19	11	compromises	compromise	VBZ
cord-007444-c9vu8ako	19	12	local	local	JJ
cord-007444-c9vu8ako	19	13	airway	airway	NN
cord-007444-c9vu8ako	19	14	defense	defense	NN
cord-007444-c9vu8ako	19	15	mechanisms	mechanism	NNS
cord-007444-c9vu8ako	19	16	by	by	IN
cord-007444-c9vu8ako	19	17	damaging	damaging	JJ
cord-007444-c9vu8ako	19	18	ciliated	ciliated	JJ
cord-007444-c9vu8ako	19	19	airway	airway	NN
cord-007444-c9vu8ako	19	20	epithelium	epithelium	NN
cord-007444-c9vu8ako	19	21	,	,	,
cord-007444-c9vu8ako	19	22	increasing	increase	VBG
cord-007444-c9vu8ako	19	23	mucus	mucus	NN
cord-007444-c9vu8ako	19	24	viscosity	viscosity	NN
cord-007444-c9vu8ako	19	25	,	,	,
cord-007444-c9vu8ako	19	26	and	and	CC
cord-007444-c9vu8ako	19	27	slowing	slow	VBG
cord-007444-c9vu8ako	19	28	mucociliary	mucociliary	JJ
cord-007444-c9vu8ako	19	29	clearance	clearance	NN
cord-007444-c9vu8ako	19	30	.	.	.
cord-007444-c9vu8ako	20	1	These	these	DT
cord-007444-c9vu8ako	20	2	conditions	condition	NNS
cord-007444-c9vu8ako	20	3	promote	promote	VBP
cord-007444-c9vu8ako	20	4	bacterial	bacterial	JJ
cord-007444-c9vu8ako	20	5	colonization	colonization	NN
cord-007444-c9vu8ako	20	6	of	of	IN
cord-007444-c9vu8ako	20	7	the	the	DT
cord-007444-c9vu8ako	20	8	lower	low	JJR
cord-007444-c9vu8ako	20	9	respiratory	respiratory	JJ
cord-007444-c9vu8ako	20	10	tract	tract	NN
cord-007444-c9vu8ako	20	11	.	.	.
cord-007444-c9vu8ako	21	1	The	the	DT
cord-007444-c9vu8ako	21	2	three	three	CD
cord-007444-c9vu8ako	21	3	major	major	JJ
cord-007444-c9vu8ako	21	4	bacterial	bacterial	JJ
cord-007444-c9vu8ako	21	5	pathogens	pathogen	NNS
cord-007444-c9vu8ako	21	6	isolated	isolate	VBN
cord-007444-c9vu8ako	21	7	from	from	IN
cord-007444-c9vu8ako	21	8	patients	patient	NNS
cord-007444-c9vu8ako	21	9	with	with	IN
cord-007444-c9vu8ako	21	10	COPD	COPD	NNP
cord-007444-c9vu8ako	21	11	during	during	IN
cord-007444-c9vu8ako	21	12	periods	period	NNS
cord-007444-c9vu8ako	21	13	of	of	IN
cord-007444-c9vu8ako	21	14	both	both	DT
cord-007444-c9vu8ako	21	15	clinical	clinical	JJ
cord-007444-c9vu8ako	21	16	stability	stability	NN
cord-007444-c9vu8ako	21	17	and	and	CC
cord-007444-c9vu8ako	21	18	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	21	19	are	be	VBP
cord-007444-c9vu8ako	21	20	nontypeable	nontypeable	JJ
cord-007444-c9vu8ako	21	21	Haemophilus	haemophilus	JJ
cord-007444-c9vu8ako	21	22	influenzae	influenzae	NN
cord-007444-c9vu8ako	21	23	,	,	,
cord-007444-c9vu8ako	21	24	Streptococcus	streptococcus	NN
cord-007444-c9vu8ako	21	25	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	21	26	,	,	,
cord-007444-c9vu8ako	21	27	and	and	CC
cord-007444-c9vu8ako	21	28	Moraxella	Moraxella	NNP
cord-007444-c9vu8ako	21	29	cafar	cafar	NNP
cord-007444-c9vu8ako	21	30	~	~	NFP
cord-007444-c9vu8ako	21	31	halis.~~	halis.~~	NNP
cord-007444-c9vu8ako	21	32	When	when	WRB
cord-007444-c9vu8ako	21	33	FEV	FEV	NNP
cord-007444-c9vu8ako	21	34	,	,	,
cord-007444-c9vu8ako	21	35	is	be	VBZ
cord-007444-c9vu8ako	21	36	severely	severely	RB
cord-007444-c9vu8ako	21	37	reduced	reduce	VBN
cord-007444-c9vu8ako	21	38	,	,	,
cord-007444-c9vu8ako	21	39	Enterobacteriaceae	Enterobacteriaceae	NNP
cord-007444-c9vu8ako	21	40	and	and	CC
cord-007444-c9vu8ako	21	41	Pseudomonas	Pseudomonas	NNP
cord-007444-c9vu8ako	21	42	aeruginosa	aeruginosa	NN
cord-007444-c9vu8ako	21	43	are	be	VBP
cord-007444-c9vu8ako	21	44	also	also	RB
cord-007444-c9vu8ako	21	45	commonly	commonly	RB
cord-007444-c9vu8ako	22	1	detected.42	detected.42	NNP
cord-007444-c9vu8ako	23	1	These	these	DT
cord-007444-c9vu8ako	23	2	organisms	organism	NNS
cord-007444-c9vu8ako	23	3	possess	possess	VBP
cord-007444-c9vu8ako	23	4	a	a	DT
cord-007444-c9vu8ako	23	5	wide	wide	JJ
cord-007444-c9vu8ako	23	6	array	array	NN
cord-007444-c9vu8ako	23	7	of	of	IN
cord-007444-c9vu8ako	23	8	virulence	virulence	NN
cord-007444-c9vu8ako	23	9	factors	factor	NNS
cord-007444-c9vu8ako	23	10	that	that	WDT
cord-007444-c9vu8ako	23	11	allow	allow	VBP
cord-007444-c9vu8ako	23	12	them	-PRON-	PRP
cord-007444-c9vu8ako	23	13	to	to	TO
cord-007444-c9vu8ako	23	14	evade	evade	VB
cord-007444-c9vu8ako	23	15	clearance	clearance	NN
cord-007444-c9vu8ako	23	16	from	from	IN
cord-007444-c9vu8ako	23	17	the	the	DT
cord-007444-c9vu8ako	23	18	lower	low	JJR
cord-007444-c9vu8ako	23	19	airways	airway	NNS
cord-007444-c9vu8ako	23	20	.	.	.
cord-007444-c9vu8ako	24	1	Although	although	IN
cord-007444-c9vu8ako	24	2	a	a	DT
cord-007444-c9vu8ako	24	3	detailed	detailed	JJ
cord-007444-c9vu8ako	24	4	discussion	discussion	NN
cord-007444-c9vu8ako	24	5	of	of	IN
cord-007444-c9vu8ako	24	6	the	the	DT
cord-007444-c9vu8ako	24	7	bacterial	bacterial	JJ
cord-007444-c9vu8ako	24	8	mechanisms	mechanism	NNS
cord-007444-c9vu8ako	24	9	of	of	IN
cord-007444-c9vu8ako	24	10	colonization	colonization	NN
cord-007444-c9vu8ako	24	11	and	and	CC
cord-007444-c9vu8ako	24	12	infection	infection	NN
cord-007444-c9vu8ako	24	13	is	be	VBZ
cord-007444-c9vu8ako	24	14	beyond	beyond	IN
cord-007444-c9vu8ako	24	15	the	the	DT
cord-007444-c9vu8ako	24	16	scope	scope	NN
cord-007444-c9vu8ako	24	17	of	of	IN
cord-007444-c9vu8ako	24	18	this	this	DT
cord-007444-c9vu8ako	24	19	article	article	NN
cord-007444-c9vu8ako	24	20	,	,	,
cord-007444-c9vu8ako	24	21	several	several	JJ
cord-007444-c9vu8ako	24	22	concepts	concept	NNS
cord-007444-c9vu8ako	24	23	are	be	VBP
cord-007444-c9vu8ako	24	24	noteworthy	noteworthy	JJ
cord-007444-c9vu8ako	24	25	.	.	.
cord-007444-c9vu8ako	25	1	Smokers	smoker	NNS
cord-007444-c9vu8ako	25	2	prone	prone	JJ
cord-007444-c9vu8ako	25	3	to	to	IN
cord-007444-c9vu8ako	25	4	acute	acute	JJ
cord-007444-c9vu8ako	25	5	episodes	episode	NNS
cord-007444-c9vu8ako	25	6	of	of	IN
cord-007444-c9vu8ako	25	7	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	26	1	have	have	VBP
cord-007444-c9vu8ako	26	2	a	a	DT
cord-007444-c9vu8ako	26	3	greater	great	JJR
cord-007444-c9vu8ako	26	4	degree	degree	NN
cord-007444-c9vu8ako	26	5	of	of	IN
cord-007444-c9vu8ako	26	6	bacterial	bacterial	JJ
cord-007444-c9vu8ako	26	7	adherence	adherence	NN
cord-007444-c9vu8ako	26	8	to	to	IN
cord-007444-c9vu8ako	26	9	oropharyngeal	oropharyngeal	JJ
cord-007444-c9vu8ako	26	10	airway	airway	NN
cord-007444-c9vu8ako	26	11	epithelial	epithelial	JJ
cord-007444-c9vu8ako	26	12	cells	cell	NNS
cord-007444-c9vu8ako	26	13	compared	compare	VBN
cord-007444-c9vu8ako	26	14	with	with	IN
cord-007444-c9vu8ako	26	15	nonsmokers	nonsmoker	NNS
cord-007444-c9vu8ako	26	16	.	.	.
cord-007444-c9vu8ako	27	1	'	'	``
cord-007444-c9vu8ako	27	2	o1	o1	NN
cord-007444-c9vu8ako	27	3	,	,	,
cord-007444-c9vu8ako	28	1	IZ3	IZ3	NNP
cord-007444-c9vu8ako	29	1	After	after	IN
cord-007444-c9vu8ako	29	2	adhering	adhere	VBG
cord-007444-c9vu8ako	29	3	to	to	IN
cord-007444-c9vu8ako	29	4	mucus	mucus	NN
cord-007444-c9vu8ako	29	5	or	or	CC
cord-007444-c9vu8ako	29	6	epithelial	epithelial	JJ
cord-007444-c9vu8ako	29	7	cells	cell	NNS
cord-007444-c9vu8ako	29	8	,	,	,
cord-007444-c9vu8ako	29	9	pathogenic	pathogenic	JJ
cord-007444-c9vu8ako	29	10	bacteria	bacteria	NNS
cord-007444-c9vu8ako	29	11	elaborate	elaborate	VBP
cord-007444-c9vu8ako	29	12	exoproducts	exoproduct	NNS
cord-007444-c9vu8ako	29	13	that	that	WDT
cord-007444-c9vu8ako	29	14	stimulate	stimulate	VBP
cord-007444-c9vu8ako	29	15	excess	excess	JJ
cord-007444-c9vu8ako	29	16	mucous	mucous	JJ
cord-007444-c9vu8ako	29	17	production	production	NN
cord-007444-c9vu8ako	29	18	,	,	,
cord-007444-c9vu8ako	29	19	'	'	''
cord-007444-c9vu8ako	29	20	disorganize	disorganize	VB
cord-007444-c9vu8ako	29	21	and	and	CC
cord-007444-c9vu8ako	29	22	slow	slow	JJ
cord-007444-c9vu8ako	29	23	ciliary	ciliary	JJ
cord-007444-c9vu8ako	29	24	beatingy5	beatingy5	NN
cord-007444-c9vu8ako	29	25	damage	damage	NN
cord-007444-c9vu8ako	29	26	epithelial	epithelial	JJ
cord-007444-c9vu8ako	29	27	and	and	CC
cord-007444-c9vu8ako	29	28	impair	impair	VB
cord-007444-c9vu8ako	29	29	immune	immune	JJ
cord-007444-c9vu8ako	29	30	effectorcell	effectorcell	JJ
cord-007444-c9vu8ako	29	31	function.=	function.=	NNP
cord-007444-c9vu8ako	30	1	Furthermore	furthermore	RB
cord-007444-c9vu8ako	30	2	,	,	,
cord-007444-c9vu8ako	30	3	bacterial	bacterial	JJ
cord-007444-c9vu8ako	30	4	proteases	protease	NNS
cord-007444-c9vu8ako	30	5	destroy	destroy	VBP
cord-007444-c9vu8ako	30	6	local	local	JJ
cord-007444-c9vu8ako	30	7	immunoglobulin^.^^	immunoglobulin^.^^	NN
cord-007444-c9vu8ako	31	1	When	when	WRB
cord-007444-c9vu8ako	31	2	these	these	DT
cord-007444-c9vu8ako	31	3	bacteria	bacteria	NNS
cord-007444-c9vu8ako	31	4	loiter	loiter	VBP
cord-007444-c9vu8ako	31	5	in	in	IN
cord-007444-c9vu8ako	31	6	the	the	DT
cord-007444-c9vu8ako	31	7	airways	airways	NNPS
cord-007444-c9vu8ako	31	8	,	,	,
cord-007444-c9vu8ako	31	9	a	a	DT
cord-007444-c9vu8ako	31	10	host	host	NN
cord-007444-c9vu8ako	31	11	inflammatory	inflammatory	JJ
cord-007444-c9vu8ako	31	12	response	response	NN
cord-007444-c9vu8ako	31	13	is	be	VBZ
cord-007444-c9vu8ako	31	14	stimulated	stimulate	VBN
cord-007444-c9vu8ako	31	15	.	.	.
cord-007444-c9vu8ako	32	1	With	with	IN
cord-007444-c9vu8ako	32	2	the	the	DT
cord-007444-c9vu8ako	32	3	movement	movement	NN
cord-007444-c9vu8ako	32	4	of	of	IN
cord-007444-c9vu8ako	32	5	large	large	JJ
cord-007444-c9vu8ako	32	6	numbers	number	NNS
cord-007444-c9vu8ako	32	7	of	of	IN
cord-007444-c9vu8ako	32	8	neutrophils	neutrophil	NNS
cord-007444-c9vu8ako	32	9	and	and	CC
cord-007444-c9vu8ako	32	10	their	-PRON-	PRP$
cord-007444-c9vu8ako	32	11	subsequent	subsequent	JJ
cord-007444-c9vu8ako	32	12	release	release	NN
cord-007444-c9vu8ako	32	13	of	of	IN
cord-007444-c9vu8ako	32	14	proteases	protease	NNS
cord-007444-c9vu8ako	32	15	and	and	CC
cord-007444-c9vu8ako	32	16	toxic	toxic	JJ
cord-007444-c9vu8ako	32	17	oxygen	oxygen	NN
cord-007444-c9vu8ako	32	18	radicals	radical	NNS
cord-007444-c9vu8ako	32	19	,	,	,
cord-007444-c9vu8ako	32	20	epithelial	epithelial	JJ
cord-007444-c9vu8ako	32	21	surface	surface	NN
cord-007444-c9vu8ako	32	22	damage	damage	NN
cord-007444-c9vu8ako	32	23	may	may	MD
cord-007444-c9vu8ako	32	24	be	be	VB
cord-007444-c9vu8ako	32	25	enhanced	enhance	VBN
cord-007444-c9vu8ako	32	26	.	.	.
cord-007444-c9vu8ako	33	1	After	after	IN
cord-007444-c9vu8ako	33	2	the	the	DT
cord-007444-c9vu8ako	33	3	inciting	incite	VBG
cord-007444-c9vu8ako	33	4	impact	impact	NN
cord-007444-c9vu8ako	33	5	of	of	IN
cord-007444-c9vu8ako	33	6	smoking	smoking	NN
cord-007444-c9vu8ako	33	7	,	,	,
cord-007444-c9vu8ako	33	8	bacterial	bacterial	JJ
cord-007444-c9vu8ako	33	9	colonization	colonization	NN
cord-007444-c9vu8ako	33	10	therefore	therefore	RB
cord-007444-c9vu8ako	33	11	begets	beget	VBZ
cord-007444-c9vu8ako	33	12	airway	airway	NN
cord-007444-c9vu8ako	33	13	damage	damage	NN
cord-007444-c9vu8ako	33	14	which	which	WDT
cord-007444-c9vu8ako	33	15	,	,	,
cord-007444-c9vu8ako	33	16	in	in	IN
cord-007444-c9vu8ako	33	17	turn	turn	NN
cord-007444-c9vu8ako	33	18	,	,	,
cord-007444-c9vu8ako	33	19	begets	beget	VBZ
cord-007444-c9vu8ako	33	20	further	further	JJ
cord-007444-c9vu8ako	33	21	inflammation	inflammation	NN
cord-007444-c9vu8ako	33	22	and	and	CC
cord-007444-c9vu8ako	33	23	bacterial	bacterial	JJ
cord-007444-c9vu8ako	33	24	colonization	colonization	NN
cord-007444-c9vu8ako	33	25	.	.	.
cord-007444-c9vu8ako	34	1	This	this	DT
cord-007444-c9vu8ako	34	2	event	event	NN
cord-007444-c9vu8ako	34	3	is	be	VBZ
cord-007444-c9vu8ako	34	4	the	the	DT
cord-007444-c9vu8ako	34	5	vicious	vicious	JJ
cord-007444-c9vu8ako	34	6	circle	circle	NN
cord-007444-c9vu8ako	34	7	hypothesis	hypothesis	NN
cord-007444-c9vu8ako	34	8	that	that	WDT
cord-007444-c9vu8ako	34	9	has	have	VBZ
cord-007444-c9vu8ako	34	10	been	be	VBN
cord-007444-c9vu8ako	34	11	proposed	propose	VBN
cord-007444-c9vu8ako	34	12	to	to	TO
cord-007444-c9vu8ako	34	13	explain	explain	VB
cord-007444-c9vu8ako	34	14	how	how	WRB
cord-007444-c9vu8ako	34	15	the	the	DT
cord-007444-c9vu8ako	34	16	bacteria	bacteria	NNS
cord-007444-c9vu8ako	34	17	-	-	HYPH
cord-007444-c9vu8ako	34	18	host	host	NN
cord-007444-c9vu8ako	34	19	interaction	interaction	NN
cord-007444-c9vu8ako	34	20	establishes	establish	VBZ
cord-007444-c9vu8ako	34	21	the	the	DT
cord-007444-c9vu8ako	34	22	insidious	insidious	JJ
cord-007444-c9vu8ako	34	23	loss	loss	NN
cord-007444-c9vu8ako	34	24	of	of	IN
cord-007444-c9vu8ako	34	25	lung	lung	NN
cord-007444-c9vu8ako	34	26	function.83	function.83	NNP
cord-007444-c9vu8ako	34	27	,	,	,
cord-007444-c9vu8ako	34	28	135	135	CD
cord-007444-c9vu8ako	34	29	Disordered	disordered	JJ
cord-007444-c9vu8ako	34	30	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	34	31	gas	gas	NN
cord-007444-c9vu8ako	34	32	exchange	exchange	NN
cord-007444-c9vu8ako	34	33	is	be	VBZ
cord-007444-c9vu8ako	34	34	characteristic	characteristic	JJ
cord-007444-c9vu8ako	34	35	of	of	IN
cord-007444-c9vu8ako	34	36	acute	acute	JJ
cord-007444-c9vu8ako	34	37	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	34	38	of	of	IN
cord-007444-c9vu8ako	34	39	COPD	COPD	NNP
cord-007444-c9vu8ako	34	40	.	.	.
cord-007444-c9vu8ako	35	1	Patients	patient	NNS
cord-007444-c9vu8ako	35	2	typically	typically	RB
cord-007444-c9vu8ako	35	3	are	be	VBP
cord-007444-c9vu8ako	35	4	found	find	VBN
cord-007444-c9vu8ako	35	5	to	to	TO
cord-007444-c9vu8ako	35	6	have	have	VB
cord-007444-c9vu8ako	35	7	severe	severe	JJ
cord-007444-c9vu8ako	35	8	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	35	9	with	with	IN
cord-007444-c9vu8ako	35	10	or	or	CC
cord-007444-c9vu8ako	35	11	without	without	IN
cord-007444-c9vu8ako	35	12	hypercarbia	hypercarbia	NNP
cord-007444-c9vu8ako	35	13	.	.	.
cord-007444-c9vu8ako	36	1	A	a	DT
cord-007444-c9vu8ako	36	2	variety	variety	NN
cord-007444-c9vu8ako	36	3	of	of	IN
cord-007444-c9vu8ako	36	4	infectious	infectious	JJ
cord-007444-c9vu8ako	36	5	and	and	CC
cord-007444-c9vu8ako	36	6	noninfectious	noninfectious	JJ
cord-007444-c9vu8ako	36	7	insults	insult	NNS
cord-007444-c9vu8ako	36	8	result	result	VBP
cord-007444-c9vu8ako	36	9	in	in	IN
cord-007444-c9vu8ako	36	10	inflammation	inflammation	NN
cord-007444-c9vu8ako	36	11	,	,	,
cord-007444-c9vu8ako	36	12	bronchospasm	bronchospasm	NN
cord-007444-c9vu8ako	36	13	,	,	,
cord-007444-c9vu8ako	36	14	and	and	CC
cord-007444-c9vu8ako	36	15	mucous	mucous	JJ
cord-007444-c9vu8ako	36	16	hypersecretion	hypersecretion	NN
cord-007444-c9vu8ako	36	17	.	.	.
cord-007444-c9vu8ako	37	1	These	these	DT
cord-007444-c9vu8ako	37	2	lead	lead	VBP
cord-007444-c9vu8ako	37	3	to	to	IN
cord-007444-c9vu8ako	37	4	acute	acute	JJ
cord-007444-c9vu8ako	37	5	airway	airway	NN
cord-007444-c9vu8ako	37	6	narrowing	narrowing	NN
cord-007444-c9vu8ako	37	7	that	that	WDT
cord-007444-c9vu8ako	37	8	aggravates	aggravate	VBZ
cord-007444-c9vu8ako	37	9	ventilation	ventilation	NN
cord-007444-c9vu8ako	37	10	-	-	HYPH
cord-007444-c9vu8ako	37	11	perfusion	perfusion	NN
cord-007444-c9vu8ako	37	12	(	(	-LRB-
cord-007444-c9vu8ako	37	13	V	v	NN
cord-007444-c9vu8ako	37	14	1	1	CD
cord-007444-c9vu8ako	37	15	Q	q	NN
cord-007444-c9vu8ako	37	16	)	)	-RRB-
cord-007444-c9vu8ako	37	17	mismatching	mismatching	NN
cord-007444-c9vu8ako	37	18	and	and	CC
cord-007444-c9vu8ako	37	19	,	,	,
cord-007444-c9vu8ako	37	20	can	can	MD
cord-007444-c9vu8ako	37	21	worsen	worsen	VB
cord-007444-c9vu8ako	37	22	existing	exist	VBG
cord-007444-c9vu8ako	37	23	hyperinflation	hyperinflation	NN
cord-007444-c9vu8ako	37	24	.	.	.
cord-007444-c9vu8ako	38	1	Although	although	IN
cord-007444-c9vu8ako	38	2	V	v	NN
cord-007444-c9vu8ako	38	3	1	1	CD
cord-007444-c9vu8ako	38	4	Q	q	NN
cord-007444-c9vu8ako	38	5	inequality	inequality	NN
cord-007444-c9vu8ako	38	6	is	be	VBZ
cord-007444-c9vu8ako	38	7	the	the	DT
cord-007444-c9vu8ako	38	8	most	most	RBS
cord-007444-c9vu8ako	38	9	important	important	JJ
cord-007444-c9vu8ako	38	10	determinant	determinant	NN
cord-007444-c9vu8ako	38	11	of	of	IN
cord-007444-c9vu8ako	38	12	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	38	13	,	,	,
cord-007444-c9vu8ako	38	14	low	low	JJ
cord-007444-c9vu8ako	38	15	mixed	mixed	JJ
cord-007444-c9vu8ako	38	16	venous	venous	JJ
cord-007444-c9vu8ako	38	17	oxygen	oxygen	NN
cord-007444-c9vu8ako	38	18	tension	tension	NN
cord-007444-c9vu8ako	38	19	(	(	-LRB-
cord-007444-c9vu8ako	38	20	PVO	PVO	NNP
cord-007444-c9vu8ako	38	21	)	)	-RRB-
cord-007444-c9vu8ako	38	22	is	be	VBZ
cord-007444-c9vu8ako	38	23	'	'	''
cord-007444-c9vu8ako	38	24	a	a	DT
cord-007444-c9vu8ako	38	25	contributing	contribute	VBG
cord-007444-c9vu8ako	38	26	factor	factor	NN
cord-007444-c9vu8ako	38	27	.	.	.
cord-007444-c9vu8ako	39	1	I6	i6	CD
cord-007444-c9vu8ako	40	1	During	during	IN
cord-007444-c9vu8ako	40	2	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	40	3	,	,	,
cord-007444-c9vu8ako	40	4	the	the	DT
cord-007444-c9vu8ako	40	5	work	work	NN
cord-007444-c9vu8ako	40	6	of	of	IN
cord-007444-c9vu8ako	40	7	breathing	breathing	NN
cord-007444-c9vu8ako	40	8	increases	increase	NNS
cord-007444-c9vu8ako	40	9	to	to	TO
cord-007444-c9vu8ako	40	10	overcome	overcome	VB
cord-007444-c9vu8ako	40	11	increased	increase	VBN
cord-007444-c9vu8ako	40	12	airway	airway	NN
cord-007444-c9vu8ako	40	13	resistance	resistance	NN
cord-007444-c9vu8ako	40	14	and	and	CC
cord-007444-c9vu8ako	40	15	dynamic	dynamic	JJ
cord-007444-c9vu8ako	40	16	hyperinflation	hyperinflation	NN
cord-007444-c9vu8ako	40	17	.	.	.
cord-007444-c9vu8ako	41	1	Oxygen	oxygen	NN
cord-007444-c9vu8ako	41	2	utilization	utilization	NN
cord-007444-c9vu8ako	41	3	by	by	IN
cord-007444-c9vu8ako	41	4	the	the	DT
cord-007444-c9vu8ako	41	5	respiratory	respiratory	JJ
cord-007444-c9vu8ako	41	6	muscles	muscle	NNS
cord-007444-c9vu8ako	41	7	therefore	therefore	RB
cord-007444-c9vu8ako	41	8	is	be	VBZ
cord-007444-c9vu8ako	41	9	markedly	markedly	RB
cord-007444-c9vu8ako	41	10	increased	increase	VBN
cord-007444-c9vu8ako	41	11	,	,	,
cord-007444-c9vu8ako	41	12	resulting	result	VBG
cord-007444-c9vu8ako	41	13	in	in	IN
cord-007444-c9vu8ako	41	14	lower	low	JJR
cord-007444-c9vu8ako	41	15	Pvo2	Pvo2	NNP
cord-007444-c9vu8ako	41	16	.	.	.
cord-007444-c9vu8ako	42	1	Fortunately	fortunately	RB
cord-007444-c9vu8ako	42	2	,	,	,
cord-007444-c9vu8ako	42	3	among	among	IN
cord-007444-c9vu8ako	42	4	patients	patient	NNS
cord-007444-c9vu8ako	42	5	with	with	IN
cord-007444-c9vu8ako	42	6	adequate	adequate	JJ
cord-007444-c9vu8ako	42	7	cardiac	cardiac	JJ
cord-007444-c9vu8ako	42	8	reserve	reserve	NN
cord-007444-c9vu8ako	42	9	,	,	,
cord-007444-c9vu8ako	42	10	increases	increase	NNS
cord-007444-c9vu8ako	42	11	in	in	IN
cord-007444-c9vu8ako	42	12	cardiac	cardiac	JJ
cord-007444-c9vu8ako	42	13	output	output	NN
cord-007444-c9vu8ako	42	14	partly	partly	RB
cord-007444-c9vu8ako	42	15	compensate	compensate	VBP
cord-007444-c9vu8ako	42	16	for	for	IN
cord-007444-c9vu8ako	42	17	diminished	diminished	JJ
cord-007444-c9vu8ako	42	18	PvoZ	PvoZ	NNP
cord-007444-c9vu8ako	42	19	to	to	TO
cord-007444-c9vu8ako	42	20	defend	defend	VB
cord-007444-c9vu8ako	42	21	arterial	arterial	JJ
cord-007444-c9vu8ako	42	22	oxygenation	oxygenation	NN
cord-007444-c9vu8ako	42	23	.	.	.
cord-007444-c9vu8ako	43	1	Among	among	IN
cord-007444-c9vu8ako	43	2	the	the	DT
cord-007444-c9vu8ako	43	3	mechanisms	mechanism	NNS
cord-007444-c9vu8ako	43	4	leading	lead	VBG
cord-007444-c9vu8ako	43	5	to	to	IN
cord-007444-c9vu8ako	43	6	hypercarbia	hypercarbia	NNP
cord-007444-c9vu8ako	43	7	,	,	,
cord-007444-c9vu8ako	43	8	V	V	NNP
cord-007444-c9vu8ako	43	9	/	/	SYM
cord-007444-c9vu8ako	43	10	Q	q	NN
cord-007444-c9vu8ako	43	11	mismatch	mismatch	NN
cord-007444-c9vu8ako	43	12	is	be	VBZ
cord-007444-c9vu8ako	43	13	probably	probably	RB
cord-007444-c9vu8ako	43	14	more	more	RBR
cord-007444-c9vu8ako	43	15	important	important	JJ
cord-007444-c9vu8ako	43	16	than	than	IN
cord-007444-c9vu8ako	43	17	hypoventilation	hypoventilation	NN
cord-007444-c9vu8ako	43	18	,	,	,
cord-007444-c9vu8ako	43	19	at	at	IN
cord-007444-c9vu8ako	43	20	least	least	JJS
cord-007444-c9vu8ako	43	21	among	among	IN
cord-007444-c9vu8ako	43	22	patients	patient	NNS
cord-007444-c9vu8ako	43	23	who	who	WP
cord-007444-c9vu8ako	43	24	recover	recover	VBP
cord-007444-c9vu8ako	43	25	from	from	IN
cord-007444-c9vu8ako	43	26	their	-PRON-	PRP$
cord-007444-c9vu8ako	43	27	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	43	28	without	without	IN
cord-007444-c9vu8ako	43	29	needing	need	VBG
cord-007444-c9vu8ako	43	30	mechanical	mechanical	JJ
cord-007444-c9vu8ako	43	31	ventilation	ventilation	NN
cord-007444-c9vu8ako	43	32	.	.	.
cord-007444-c9vu8ako	44	1	This	this	DT
cord-007444-c9vu8ako	44	2	concept	concept	NN
cord-007444-c9vu8ako	44	3	is	be	VBZ
cord-007444-c9vu8ako	44	4	supported	support	VBN
cord-007444-c9vu8ako	44	5	by	by	IN
cord-007444-c9vu8ako	44	6	the	the	DT
cord-007444-c9vu8ako	44	7	observation	observation	NN
cord-007444-c9vu8ako	44	8	that	that	IN
cord-007444-c9vu8ako	44	9	,	,	,
cord-007444-c9vu8ako	44	10	during	during	IN
cord-007444-c9vu8ako	44	11	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	44	12	,	,	,
cord-007444-c9vu8ako	44	13	patients	patient	NNS
cord-007444-c9vu8ako	44	14	are	be	VBP
cord-007444-c9vu8ako	44	15	often	often	RB
cord-007444-c9vu8ako	44	16	hypercarbic	hypercarbic	JJ
cord-007444-c9vu8ako	44	17	despite	despite	IN
cord-007444-c9vu8ako	44	18	increased	increase	VBN
cord-007444-c9vu8ako	44	19	minute	minute	NN
cord-007444-c9vu8ako	44	20	ventilation	ventilation	NN
cord-007444-c9vu8ako	44	21	.	.	.
cord-007444-c9vu8ako	45	1	'	'	``
cord-007444-c9vu8ako	45	2	6	6	CD
cord-007444-c9vu8ako	45	3	,	,	,
cord-007444-c9vu8ako	45	4	13	13	CD
cord-007444-c9vu8ako	45	5	'	'	POS
cord-007444-c9vu8ako	45	6	Hypoventilation	Hypoventilation	NNP
cord-007444-c9vu8ako	45	7	may	may	MD
cord-007444-c9vu8ako	45	8	be	be	VB
cord-007444-c9vu8ako	45	9	an	an	DT
cord-007444-c9vu8ako	45	10	additional	additional	JJ
cord-007444-c9vu8ako	45	11	mechanism	mechanism	NN
cord-007444-c9vu8ako	45	12	of	of	IN
cord-007444-c9vu8ako	45	13	hypercarbia	hypercarbia	NN
cord-007444-c9vu8ako	45	14	if	if	IN
cord-007444-c9vu8ako	45	15	respiratory	respiratory	JJ
cord-007444-c9vu8ako	45	16	muscle	muscle	NN
cord-007444-c9vu8ako	45	17	fatigue	fatigue	NN
cord-007444-c9vu8ako	45	18	and	and	CC
cord-007444-c9vu8ako	45	19	acute	acute	JJ
cord-007444-c9vu8ako	45	20	respiratory	respiratory	JJ
cord-007444-c9vu8ako	45	21	failure	failure	NN
cord-007444-c9vu8ako	45	22	ensue	ensue	NN
cord-007444-c9vu8ako	45	23	.	.	.
cord-007444-c9vu8ako	46	1	The	the	DT
cord-007444-c9vu8ako	46	2	relationshp	relationshp	NN
cord-007444-c9vu8ako	46	3	between	between	IN
cord-007444-c9vu8ako	46	4	bacterial	bacterial	JJ
cord-007444-c9vu8ako	46	5	infection	infection	NN
cord-007444-c9vu8ako	46	6	and	and	CC
cord-007444-c9vu8ako	46	7	COPD	COPD	NNP
cord-007444-c9vu8ako	46	8	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	46	9	is	be	VBZ
cord-007444-c9vu8ako	46	10	not	not	RB
cord-007444-c9vu8ako	46	11	precisely	precisely	RB
cord-007444-c9vu8ako	46	12	understood	understand	VBN
cord-007444-c9vu8ako	46	13	.	.	.
cord-007444-c9vu8ako	47	1	Several	several	JJ
cord-007444-c9vu8ako	47	2	lines	line	NNS
cord-007444-c9vu8ako	47	3	of	of	IN
cord-007444-c9vu8ako	47	4	evidence	evidence	NN
cord-007444-c9vu8ako	47	5	,	,	,
cord-007444-c9vu8ako	47	6	however	however	RB
cord-007444-c9vu8ako	47	7	,	,	,
cord-007444-c9vu8ako	47	8	have	have	VBP
cord-007444-c9vu8ako	47	9	established	establish	VBN
cord-007444-c9vu8ako	47	10	an	an	DT
cord-007444-c9vu8ako	47	11	important	important	JJ
cord-007444-c9vu8ako	47	12	role	role	NN
cord-007444-c9vu8ako	47	13	for	for	IN
cord-007444-c9vu8ako	47	14	bacterial	bacterial	JJ
cord-007444-c9vu8ako	47	15	infection	infection	NN
cord-007444-c9vu8ako	47	16	in	in	IN
cord-007444-c9vu8ako	47	17	many	many	JJ
cord-007444-c9vu8ako	47	18	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	47	19	.	.	.
cord-007444-c9vu8ako	48	1	High	high	JJ
cord-007444-c9vu8ako	48	2	titers	titer	NNS
cord-007444-c9vu8ako	48	3	of	of	IN
cord-007444-c9vu8ako	48	4	antibody	antibody	NN
cord-007444-c9vu8ako	48	5	against	against	IN
cord-007444-c9vu8ako	48	6	nontypeable	nontypeable	NNP
cord-007444-c9vu8ako	48	7	H.	H.	NNP
cord-007444-c9vu8ako	48	8	influenzaes4	influenzaes4	NN
cord-007444-c9vu8ako	48	9	,	,	,
cord-007444-c9vu8ako	48	10	97	97	CD
cord-007444-c9vu8ako	48	11	,	,	,
cord-007444-c9vu8ako	48	12	114	114	CD
cord-007444-c9vu8ako	48	13	and	and	CC
cord-007444-c9vu8ako	48	14	M	M	NNP
cord-007444-c9vu8ako	48	15	.	.	.
cord-007444-c9vu8ako	49	1	~a	~a	NNP
cord-007444-c9vu8ako	49	2	t	t	XX
cord-007444-c9vu8ako	50	1	a	a	DT
cord-007444-c9vu8ako	50	2	r	r	NN
cord-007444-c9vu8ako	50	3	r	r	NN
cord-007444-c9vu8ako	50	4	h	h	NN
cord-007444-c9vu8ako	51	1	a	a	LS
cord-007444-c9vu8ako	52	1	l	l	NNP
cord-007444-c9vu8ako	53	1	i	i	PRP
cord-007444-c9vu8ako	53	2	s~~	s~~	VBP
cord-007444-c9vu8ako	53	3	are	be	VBP
cord-007444-c9vu8ako	53	4	found	find	VBN
cord-007444-c9vu8ako	53	5	following	follow	VBG
cord-007444-c9vu8ako	53	6	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	53	7	.	.	.
cord-007444-c9vu8ako	54	1	Although	although	IN
cord-007444-c9vu8ako	54	2	bacterial	bacterial	JJ
cord-007444-c9vu8ako	54	3	colonization	colonization	NN
cord-007444-c9vu8ako	54	4	of	of	IN
cord-007444-c9vu8ako	54	5	the	the	DT
cord-007444-c9vu8ako	54	6	distal	distal	JJ
cord-007444-c9vu8ako	54	7	airways	airways	NNP
cord-007444-c9vu8ako	54	8	is	be	VBZ
cord-007444-c9vu8ako	54	9	common	common	JJ
cord-007444-c9vu8ako	54	10	in	in	IN
cord-007444-c9vu8ako	54	11	stable	stable	JJ
cord-007444-c9vu8ako	54	12	COPD	COPD	NNP
cord-007444-c9vu8ako	54	13	,	,	,
cord-007444-c9vu8ako	54	14	patients	patient	NNS
cord-007444-c9vu8ako	54	15	with	with	IN
cord-007444-c9vu8ako	54	16	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	54	17	often	often	RB
cord-007444-c9vu8ako	54	18	have	have	VBP
cord-007444-c9vu8ako	54	19	higher	high	JJR
cord-007444-c9vu8ako	54	20	numbers	number	NNS
cord-007444-c9vu8ako	54	21	of	of	IN
cord-007444-c9vu8ako	54	22	organisms	organism	NNS
cord-007444-c9vu8ako	54	23	.	.	.
cord-007444-c9vu8ako	54	24	"	"	''
cord-007444-c9vu8ako	54	25	,	,	,
cord-007444-c9vu8ako	54	26	Table	Table	NNP
cord-007444-c9vu8ako	54	27	1	1	CD
cord-007444-c9vu8ako	54	28	summarizes	summarize	VBZ
cord-007444-c9vu8ako	54	29	studies	study	NNS
cord-007444-c9vu8ako	54	30	using	use	VBG
cord-007444-c9vu8ako	54	31	protected	protect	VBN
cord-007444-c9vu8ako	54	32	specimen	specimen	JJ
cord-007444-c9vu8ako	54	33	brushes	brush	NNS
cord-007444-c9vu8ako	54	34	to	to	TO
cord-007444-c9vu8ako	54	35	define	define	VB
cord-007444-c9vu8ako	54	36	the	the	DT
cord-007444-c9vu8ako	54	37	microflora	microflora	NN
cord-007444-c9vu8ako	54	38	of	of	IN
cord-007444-c9vu8ako	54	39	the	the	DT
cord-007444-c9vu8ako	54	40	distal	distal	JJ
cord-007444-c9vu8ako	54	41	airways	airway	NNS
cord-007444-c9vu8ako	54	42	in	in	IN
cord-007444-c9vu8ako	54	43	COPD	COPD	NNP
cord-007444-c9vu8ako	54	44	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	54	45	.	.	.
cord-007444-c9vu8ako	55	1	Mons6	Mons6	NNP
cord-007444-c9vu8ako	55	2	et	et	NNP
cord-007444-c9vu8ako	55	3	a155	a155	NNP
cord-007444-c9vu8ako	55	4	found	find	VBD
cord-007444-c9vu8ako	55	5	positive	positive	JJ
cord-007444-c9vu8ako	55	6	bacterial	bacterial	JJ
cord-007444-c9vu8ako	55	7	cultures	culture	NNS
cord-007444-c9vu8ako	55	8	in	in	IN
cord-007444-c9vu8ako	55	9	52	52	CD
cord-007444-c9vu8ako	55	10	%	%	NN
cord-007444-c9vu8ako	55	11	of	of	IN
cord-007444-c9vu8ako	55	12	outpatients	outpatient	NNS
cord-007444-c9vu8ako	55	13	with	with	IN
cord-007444-c9vu8ako	55	14	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	55	15	.	.	.
cord-007444-c9vu8ako	56	1	Compared	compare	VBN
cord-007444-c9vu8ako	56	2	with	with	IN
cord-007444-c9vu8ako	56	3	stable	stable	JJ
cord-007444-c9vu8ako	56	4	patients	patient	NNS
cord-007444-c9vu8ako	56	5	,	,	,
cord-007444-c9vu8ako	56	6	exacerbated	exacerbate	VBD
cord-007444-c9vu8ako	56	7	patients	patient	NNS
cord-007444-c9vu8ako	56	8	were	be	VBD
cord-007444-c9vu8ako	56	9	twice	twice	RB
cord-007444-c9vu8ako	56	10	as	as	RB
cord-007444-c9vu8ako	56	11	likely	likely	JJ
cord-007444-c9vu8ako	56	12	to	to	TO
cord-007444-c9vu8ako	56	13	have	have	VB
cord-007444-c9vu8ako	56	14	positive	positive	JJ
cord-007444-c9vu8ako	56	15	cultures	culture	NNS
cord-007444-c9vu8ako	56	16	(	(	-LRB-
cord-007444-c9vu8ako	56	17	i.e.	i.e.	FW
cord-007444-c9vu8ako	56	18	,	,	,
cord-007444-c9vu8ako	56	19	2	2	CD
cord-007444-c9vu8ako	56	20	1000	1000	CD
cord-007444-c9vu8ako	56	21	CFU	CFU	NNP
cord-007444-c9vu8ako	56	22	/	/	SYM
cord-007444-c9vu8ako	56	23	mL	mL	NNP
cord-007444-c9vu8ako	56	24	)	)	-RRB-
cord-007444-c9vu8ako	56	25	and	and	CC
cord-007444-c9vu8ako	56	26	five	five	CD
cord-007444-c9vu8ako	56	27	times	time	NNS
cord-007444-c9vu8ako	56	28	as	as	RB
cord-007444-c9vu8ako	56	29	likely	likely	JJ
cord-007444-c9vu8ako	56	30	to	to	TO
cord-007444-c9vu8ako	56	31	have	have	VB
cord-007444-c9vu8ako	56	32	bacterial	bacterial	JJ
cord-007444-c9vu8ako	56	33	counts	count	NNS
cord-007444-c9vu8ako	57	1	greater	great	JJR
cord-007444-c9vu8ako	57	2	than	than	IN
cord-007444-c9vu8ako	57	3	10,000	10,000	CD
cord-007444-c9vu8ako	57	4	CFU	CFU	NNP
cord-007444-c9vu8ako	57	5	/	/	,
cord-007444-c9vu8ako	57	6	mL.80	mL.80	VBN
cord-007444-c9vu8ako	58	1	Likewise	likewise	RB
cord-007444-c9vu8ako	58	2	,	,	,
cord-007444-c9vu8ako	58	3	S.	S.	NNP
cord-007444-c9vu8ako	58	4	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	58	5	is	be	VBZ
cord-007444-c9vu8ako	58	6	more	more	RBR
cord-007444-c9vu8ako	58	7	likely	likely	JJ
cord-007444-c9vu8ako	58	8	to	to	TO
cord-007444-c9vu8ako	58	9	be	be	VB
cord-007444-c9vu8ako	58	10	found	find	VBN
cord-007444-c9vu8ako	58	11	in	in	IN
cord-007444-c9vu8ako	58	12	sputum	sputum	NN
cord-007444-c9vu8ako	58	13	during	during	IN
cord-007444-c9vu8ako	58	14	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	58	15	than	than	IN
cord-007444-c9vu8ako	58	16	remission	remission	NN
cord-007444-c9vu8ako	58	17	.	.	.
cord-007444-c9vu8ako	59	1	Fagon+	Fagon+	NNP
cord-007444-c9vu8ako	59	2	'	'	''
cord-007444-c9vu8ako	60	1	et	et	NNP
cord-007444-c9vu8ako	60	2	a1	a1	NNP
cord-007444-c9vu8ako	60	3	found	find	VBD
cord-007444-c9vu8ako	60	4	evidence	evidence	NN
cord-007444-c9vu8ako	60	5	of	of	IN
cord-007444-c9vu8ako	60	6	bacterial	bacterial	JJ
cord-007444-c9vu8ako	60	7	infection	infection	NN
cord-007444-c9vu8ako	60	8	in	in	IN
cord-007444-c9vu8ako	60	9	50	50	CD
cord-007444-c9vu8ako	60	10	%	%	NN
cord-007444-c9vu8ako	60	11	of	of	IN
cord-007444-c9vu8ako	60	12	patients	patient	NNS
cord-007444-c9vu8ako	60	13	who	who	WP
cord-007444-c9vu8ako	60	14	required	require	VBD
cord-007444-c9vu8ako	60	15	mechanical	mechanical	JJ
cord-007444-c9vu8ako	60	16	ventilation	ventilation	NN
cord-007444-c9vu8ako	60	17	.	.	.
cord-007444-c9vu8ako	61	1	Streptococcus	streptococcus	NN
cord-007444-c9vu8ako	61	2	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	61	3	,	,	,
cord-007444-c9vu8ako	61	4	H.	H.	NNP
cord-007444-c9vu8ako	61	5	influenzae	influenzae	NN
cord-007444-c9vu8ako	61	6	,	,	,
cord-007444-c9vu8ako	61	7	M	M	NNP
cord-007444-c9vu8ako	61	8	.	.	NNP
cord-007444-c9vu8ako	61	9	cafarrhalis	cafarrhalis	NNP
cord-007444-c9vu8ako	61	10	,	,	,
cord-007444-c9vu8ako	61	11	and	and	CC
cord-007444-c9vu8ako	61	12	enteric	enteric	JJ
cord-007444-c9vu8ako	61	13	gram	gram	NN
cord-007444-c9vu8ako	61	14	-	-	HYPH
cord-007444-c9vu8ako	61	15	negative	negative	JJ
cord-007444-c9vu8ako	61	16	organisms	organism	NNS
cord-007444-c9vu8ako	61	17	collectively	collectively	RB
cord-007444-c9vu8ako	61	18	accounted	account	VBD
cord-007444-c9vu8ako	61	19	for	for	IN
cord-007444-c9vu8ako	61	20	55	55	CD
cord-007444-c9vu8ako	61	21	%	%	NN
cord-007444-c9vu8ako	61	22	of	of	IN
cord-007444-c9vu8ako	61	23	the	the	DT
cord-007444-c9vu8ako	61	24	isolates	isolate	NNS
cord-007444-c9vu8ako	61	25	.	.	.
cord-007444-c9vu8ako	62	1	The	the	DT
cord-007444-c9vu8ako	62	2	investigators	investigator	NNS
cord-007444-c9vu8ako	62	3	did	do	VBD
cord-007444-c9vu8ako	62	4	not	not	RB
cord-007444-c9vu8ako	62	5	attempt	attempt	VB
cord-007444-c9vu8ako	62	6	to	to	TO
cord-007444-c9vu8ako	62	7	identify	identify	VB
cord-007444-c9vu8ako	62	8	M	M	NNP
cord-007444-c9vu8ako	62	9	.	.	.
cord-007444-c9vu8ako	63	1	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	63	2	,	,	,
cord-007444-c9vu8ako	63	3	C.	C.	NNP
cord-007444-c9vu8ako	63	4	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	63	5	,	,	,
cord-007444-c9vu8ako	63	6	or	or	CC
cord-007444-c9vu8ako	63	7	respiratory	respiratory	JJ
cord-007444-c9vu8ako	63	8	viruses	virus	NNS
cord-007444-c9vu8ako	63	9	.	.	.
cord-007444-c9vu8ako	64	1	Interestingly	interestingly	RB
cord-007444-c9vu8ako	64	2	,	,	,
cord-007444-c9vu8ako	64	3	gram	gram	NN
cord-007444-c9vu8ako	64	4	-	-	HYPH
cord-007444-c9vu8ako	64	5	negative	negative	JJ
cord-007444-c9vu8ako	64	6	bacteria	bacteria	NNS
cord-007444-c9vu8ako	64	7	accounted	account	VBD
cord-007444-c9vu8ako	64	8	for	for	IN
cord-007444-c9vu8ako	64	9	64	64	CD
cord-007444-c9vu8ako	64	10	%	%	NN
cord-007444-c9vu8ako	64	11	of	of	IN
cord-007444-c9vu8ako	64	12	isolates	isolate	NNS
cord-007444-c9vu8ako	64	13	,	,	,
cord-007444-c9vu8ako	64	14	and	and	CC
cord-007444-c9vu8ako	64	15	nearly	nearly	RB
cord-007444-c9vu8ako	64	16	half	half	NN
cord-007444-c9vu8ako	64	17	of	of	IN
cord-007444-c9vu8ako	64	18	these	these	DT
cord-007444-c9vu8ako	64	19	were	be	VBD
cord-007444-c9vu8ako	64	20	H.	H.	NNP
cord-007444-c9vu8ako	64	21	parainfluenzae	parainfluenzae	NNS
cord-007444-c9vu8ako	64	22	.	.	.
cord-007444-c9vu8ako	65	1	Yet	yet	RB
cord-007444-c9vu8ako	65	2	,	,	,
cord-007444-c9vu8ako	65	3	similar	similar	JJ
cord-007444-c9vu8ako	65	4	studies	study	NNS
cord-007444-c9vu8ako	65	5	employing	employ	VBG
cord-007444-c9vu8ako	65	6	protected	protect	VBN
cord-007444-c9vu8ako	65	7	brush	brush	NN
cord-007444-c9vu8ako	65	8	specimens	specimen	NNS
cord-007444-c9vu8ako	65	9	have	have	VBP
cord-007444-c9vu8ako	65	10	not	not	RB
cord-007444-c9vu8ako	65	11	detected	detect	VBN
cord-007444-c9vu8ako	65	12	H.	H.	NNP
cord-007444-c9vu8ako	65	13	parainfluenzae	parainfluenzae	NNS
cord-007444-c9vu8ako	65	14	among	among	IN
cord-007444-c9vu8ako	65	15	patients	patient	NNS
cord-007444-c9vu8ako	65	16	with	with	IN
cord-007444-c9vu8ako	65	17	COPD	COPD	NNP
cord-007444-c9vu8ako	65	18	exacerbations.80	exacerbations.80	NNP
cord-007444-c9vu8ako	66	1	*	*	NFP
cord-007444-c9vu8ako	67	1	Moreover	moreover	RB
cord-007444-c9vu8ako	67	2	,	,	,
cord-007444-c9vu8ako	67	3	Smith	Smith	NNP
cord-007444-c9vu8ako	67	4	et	et	NNP
cord-007444-c9vu8ako	67	5	a	a	DT
cord-007444-c9vu8ako	67	6	P	p	NN
cord-007444-c9vu8ako	67	7	4	4	CD
cord-007444-c9vu8ako	67	8	were	be	VBD
cord-007444-c9vu8ako	67	9	unable	unable	JJ
cord-007444-c9vu8ako	67	10	to	to	TO
cord-007444-c9vu8ako	67	11	demonstrate	demonstrate	VB
cord-007444-c9vu8ako	67	12	rises	rise	NNS
cord-007444-c9vu8ako	67	13	in	in	IN
cord-007444-c9vu8ako	67	14	antibody	antibody	NN
cord-007444-c9vu8ako	67	15	against	against	IN
cord-007444-c9vu8ako	67	16	H.	H.	NNP
cord-007444-c9vu8ako	67	17	parainfluenzae	parainfluenzae	NNS
cord-007444-c9vu8ako	67	18	following	follow	VBG
cord-007444-c9vu8ako	67	19	COPD	COPD	NNP
cord-007444-c9vu8ako	67	20	-	-	HYPH
cord-007444-c9vu8ako	67	21	related	relate	VBN
cord-007444-c9vu8ako	67	22	acute	acute	JJ
cord-007444-c9vu8ako	67	23	respiratory	respiratory	JJ
cord-007444-c9vu8ako	67	24	illnesses	illness	NNS
cord-007444-c9vu8ako	67	25	.	.	.
cord-007444-c9vu8ako	68	1	It	-PRON-	PRP
cord-007444-c9vu8ako	68	2	seems	seem	VBZ
cord-007444-c9vu8ako	68	3	justified	justified	JJ
cord-007444-c9vu8ako	68	4	therefore	therefore	RB
cord-007444-c9vu8ako	68	5	to	to	TO
cord-007444-c9vu8ako	68	6	consider	consider	VB
cord-007444-c9vu8ako	68	7	H.	H.	NNP
cord-007444-c9vu8ako	68	8	parainfluenzae	parainfluenzae	NNS
cord-007444-c9vu8ako	68	9	as	as	IN
cord-007444-c9vu8ako	68	10	generally	generally	RB
cord-007444-c9vu8ako	68	11	nonpathogenic	nonpathogenic	JJ
cord-007444-c9vu8ako	68	12	.	.	.
cord-007444-c9vu8ako	69	1	In	in	IN
cord-007444-c9vu8ako	69	2	contrast	contrast	NN
cord-007444-c9vu8ako	69	3	to	to	IN
cord-007444-c9vu8ako	69	4	the	the	DT
cord-007444-c9vu8ako	69	5	findings	finding	NNS
cord-007444-c9vu8ako	69	6	of	of	IN
cord-007444-c9vu8ako	69	7	Fagon	Fagon	NNP
cord-007444-c9vu8ako	69	8	et	et	NNP
cord-007444-c9vu8ako	69	9	al,'I5	al,'I5	NNP
cord-007444-c9vu8ako	69	10	a	a	DT
cord-007444-c9vu8ako	69	11	more	more	RBR
cord-007444-c9vu8ako	69	12	comprehensive	comprehensive	JJ
cord-007444-c9vu8ako	69	13	microbiologic	microbiologic	JJ
cord-007444-c9vu8ako	69	14	survey	survey	NN
cord-007444-c9vu8ako	69	15	of	of	IN
cord-007444-c9vu8ako	69	16	patients	patient	NNS
cord-007444-c9vu8ako	69	17	with	with	IN
cord-007444-c9vu8ako	69	18	severe	severe	JJ
cord-007444-c9vu8ako	69	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	69	20	found	find	VBD
cord-007444-c9vu8ako	69	21	a	a	DT
cord-007444-c9vu8ako	69	22	higher	high	JJR
cord-007444-c9vu8ako	69	23	incidence	incidence	NN
cord-007444-c9vu8ako	69	24	of	of	IN
cord-007444-c9vu8ako	69	25	potential	potential	JJ
cord-007444-c9vu8ako	69	26	pathogens	pathogen	NNS
cord-007444-c9vu8ako	69	27	.	.	.
cord-007444-c9vu8ako	70	1	Overall	overall	RB
cord-007444-c9vu8ako	70	2	,	,	,
cord-007444-c9vu8ako	70	3	72	72	CD
cord-007444-c9vu8ako	70	4	%	%	NN
cord-007444-c9vu8ako	70	5	of	of	IN
cord-007444-c9vu8ako	70	6	patients	patient	NNS
cord-007444-c9vu8ako	70	7	had	have	VBD
cord-007444-c9vu8ako	70	8	at	at	RB
cord-007444-c9vu8ako	70	9	least	least	RBS
cord-007444-c9vu8ako	70	10	one	one	CD
cord-007444-c9vu8ako	70	11	positive	positive	JJ
cord-007444-c9vu8ako	70	12	bacterial	bacterial	JJ
cord-007444-c9vu8ako	70	13	culture	culture	NN
cord-007444-c9vu8ako	70	14	or	or	CC
cord-007444-c9vu8ako	70	15	positive	positive	JJ
cord-007444-c9vu8ako	70	16	serology	serology	NN
cord-007444-c9vu8ako	70	17	for	for	IN
cord-007444-c9vu8ako	70	18	C.	C.	NNP
cord-007444-c9vu8ako	70	19	pneumoniae	pneumoniae	NNS
cord-007444-c9vu8ako	70	20	or	or	CC
cord-007444-c9vu8ako	70	21	respiratory	respiratory	JJ
cord-007444-c9vu8ako	70	22	viruses	virus	NNS
cord-007444-c9vu8ako	70	23	.	.	.
cord-007444-c9vu8ako	71	1	All	all	DT
cord-007444-c9vu8ako	71	2	cultures	culture	NNS
cord-007444-c9vu8ako	71	3	were	be	VBD
cord-007444-c9vu8ako	71	4	obtained	obtain	VBN
cord-007444-c9vu8ako	71	5	within	within	IN
cord-007444-c9vu8ako	71	6	48	48	CD
cord-007444-c9vu8ako	71	7	hours	hour	NNS
cord-007444-c9vu8ako	71	8	of	of	IN
cord-007444-c9vu8ako	71	9	admission	admission	NN
cord-007444-c9vu8ako	71	10	,	,	,
cord-007444-c9vu8ako	71	11	thereby	thereby	RB
cord-007444-c9vu8ako	71	12	reducing	reduce	VBG
cord-007444-c9vu8ako	71	13	the	the	DT
cord-007444-c9vu8ako	71	14	likelihood	likelihood	NN
cord-007444-c9vu8ako	71	15	of	of	IN
cord-007444-c9vu8ako	71	16	nosocomial	nosocomial	JJ
cord-007444-c9vu8ako	71	17	infection	infection	NN
cord-007444-c9vu8ako	71	18	.	.	.
cord-007444-c9vu8ako	72	1	Streptococcus	streptococcus	NN
cord-007444-c9vu8ako	72	2	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	72	3	,	,	,
cord-007444-c9vu8ako	72	4	H.	H.	NNP
cord-007444-c9vu8ako	72	5	influenzae	influenzae	NN
cord-007444-c9vu8ako	72	6	,	,	,
cord-007444-c9vu8ako	72	7	and	and	CC
cord-007444-c9vu8ako	72	8	M	M	NNP
cord-007444-c9vu8ako	72	9	.	.	NNP
cord-007444-c9vu8ako	72	10	cafarrhalis	cafarrhalis	NNP
cord-007444-c9vu8ako	72	11	accounted	account	VBD
cord-007444-c9vu8ako	72	12	for	for	IN
cord-007444-c9vu8ako	72	13	56	56	CD
cord-007444-c9vu8ako	72	14	%	%	NN
cord-007444-c9vu8ako	72	15	of	of	IN
cord-007444-c9vu8ako	72	16	potential	potential	JJ
cord-007444-c9vu8ako	72	17	pathogens	pathogen	NNS
cord-007444-c9vu8ako	72	18	.	.	.
cord-007444-c9vu8ako	73	1	Strikingly	strikingly	RB
cord-007444-c9vu8ako	73	2	,	,	,
cord-007444-c9vu8ako	73	3	gramnegative	gramnegative	JJ
cord-007444-c9vu8ako	73	4	enteric	enteric	JJ
cord-007444-c9vu8ako	73	5	bacteria	bacteria	NNS
cord-007444-c9vu8ako	73	6	and	and	CC
cord-007444-c9vu8ako	73	7	Pseudomonas	Pseudomonas	NNP
cord-007444-c9vu8ako	73	8	or	or	CC
cord-007444-c9vu8ako	73	9	Stenotrophomonas	Stenotrophomonas	NNP
cord-007444-c9vu8ako	73	10	represented	represent	VBD
cord-007444-c9vu8ako	73	11	39	39	CD
cord-007444-c9vu8ako	73	12	%	%	NN
cord-007444-c9vu8ako	73	13	of	of	IN
cord-007444-c9vu8ako	73	14	potential	potential	NN
cord-007444-c9vu8ako	74	1	This	this	DT
cord-007444-c9vu8ako	74	2	study	study	NN
cord-007444-c9vu8ako	74	3	suggests	suggest	VBZ
cord-007444-c9vu8ako	74	4	that	that	IN
cord-007444-c9vu8ako	74	5	a	a	DT
cord-007444-c9vu8ako	74	6	broader	broad	JJR
cord-007444-c9vu8ako	74	7	profile	profile	NN
cord-007444-c9vu8ako	74	8	of	of	IN
cord-007444-c9vu8ako	74	9	potential	potential	JJ
cord-007444-c9vu8ako	74	10	pathogens	pathogen	NNS
cord-007444-c9vu8ako	74	11	may	may	MD
cord-007444-c9vu8ako	74	12	be	be	VB
cord-007444-c9vu8ako	74	13	present	present	JJ
cord-007444-c9vu8ako	74	14	among	among	IN
cord-007444-c9vu8ako	74	15	patients	patient	NNS
cord-007444-c9vu8ako	74	16	with	with	IN
cord-007444-c9vu8ako	74	17	COPD	COPD	NNP
cord-007444-c9vu8ako	74	18	with	with	IN
cord-007444-c9vu8ako	74	19	severe	severe	JJ
cord-007444-c9vu8ako	74	20	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	74	21	.	.	.
cord-007444-c9vu8ako	75	1	Although	although	IN
cord-007444-c9vu8ako	75	2	these	these	DT
cord-007444-c9vu8ako	75	3	findings	finding	NNS
cord-007444-c9vu8ako	75	4	should	should	MD
cord-007444-c9vu8ako	75	5	be	be	VB
cord-007444-c9vu8ako	75	6	confirmed	confirm	VBN
cord-007444-c9vu8ako	75	7	in	in	IN
cord-007444-c9vu8ako	75	8	a	a	DT
cord-007444-c9vu8ako	75	9	larger	large	JJR
cord-007444-c9vu8ako	75	10	study	study	NN
cord-007444-c9vu8ako	75	11	,	,	,
cord-007444-c9vu8ako	75	12	the	the	DT
cord-007444-c9vu8ako	75	13	choice	choice	NN
cord-007444-c9vu8ako	75	14	of	of	IN
cord-007444-c9vu8ako	75	15	empiric	empiric	JJ
cord-007444-c9vu8ako	75	16	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	75	17	for	for	IN
cord-007444-c9vu8ako	75	18	patients	patient	NNS
cord-007444-c9vu8ako	75	19	with	with	IN
cord-007444-c9vu8ako	75	20	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	75	21	should	should	MD
cord-007444-c9vu8ako	75	22	be	be	VB
cord-007444-c9vu8ako	75	23	based	base	VBN
cord-007444-c9vu8ako	75	24	in	in	IN
cord-007444-c9vu8ako	75	25	part	part	NN
cord-007444-c9vu8ako	75	26	on	on	IN
cord-007444-c9vu8ako	75	27	the	the	DT
cord-007444-c9vu8ako	75	28	degree	degree	NN
cord-007444-c9vu8ako	75	29	of	of	IN
cord-007444-c9vu8ako	75	30	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	75	31	severity	severity	NN
cord-007444-c9vu8ako	75	32	,	,	,
cord-007444-c9vu8ako	75	33	and	and	CC
cord-007444-c9vu8ako	75	34	broaderspectrum	broaderspectrum	NNP
cord-007444-c9vu8ako	75	35	initial	initial	JJ
cord-007444-c9vu8ako	75	36	coverage	coverage	NN
cord-007444-c9vu8ako	75	37	may	may	MD
cord-007444-c9vu8ako	75	38	be	be	VB
cord-007444-c9vu8ako	75	39	warranted	warrant	VBN
cord-007444-c9vu8ako	75	40	for	for	IN
cord-007444-c9vu8ako	75	41	patients	patient	NNS
cord-007444-c9vu8ako	75	42	with	with	IN
cord-007444-c9vu8ako	75	43	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	75	44	who	who	WP
cord-007444-c9vu8ako	75	45	present	present	VBP
cord-007444-c9vu8ako	75	46	with	with	IN
cord-007444-c9vu8ako	75	47	respiratory	respiratory	JJ
cord-007444-c9vu8ako	75	48	failure	failure	NN
cord-007444-c9vu8ako	75	49	and	and	CC
cord-007444-c9vu8ako	75	50	require	require	VB
cord-007444-c9vu8ako	75	51	mechanical	mechanical	JJ
cord-007444-c9vu8ako	75	52	ventilation	ventilation	NN
cord-007444-c9vu8ako	75	53	.	.	.
cord-007444-c9vu8ako	76	1	The	the	DT
cord-007444-c9vu8ako	76	2	source	source	NN
cord-007444-c9vu8ako	76	3	of	of	IN
cord-007444-c9vu8ako	76	4	bacterial	bacterial	JJ
cord-007444-c9vu8ako	76	5	infection	infection	NN
cord-007444-c9vu8ako	76	6	during	during	IN
cord-007444-c9vu8ako	76	7	a	a	DT
cord-007444-c9vu8ako	76	8	COPD	COPD	NNP
cord-007444-c9vu8ako	76	9	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	76	10	may	may	MD
cord-007444-c9vu8ako	76	11	be	be	VB
cord-007444-c9vu8ako	76	12	endogenous	endogenous	JJ
cord-007444-c9vu8ako	76	13	or	or	CC
cord-007444-c9vu8ako	76	14	exogenous	exogenous	JJ
cord-007444-c9vu8ako	76	15	.	.	.
cord-007444-c9vu8ako	77	1	In	in	IN
cord-007444-c9vu8ako	77	2	a	a	DT
cord-007444-c9vu8ako	77	3	small	small	JJ
cord-007444-c9vu8ako	77	4	group	group	NN
cord-007444-c9vu8ako	77	5	of	of	IN
cord-007444-c9vu8ako	77	6	patients	patient	NNS
cord-007444-c9vu8ako	77	7	followed	follow	VBD
cord-007444-c9vu8ako	77	8	for	for	IN
cord-007444-c9vu8ako	77	9	3	3	CD
cord-007444-c9vu8ako	77	10	years	year	NNS
cord-007444-c9vu8ako	77	11	,	,	,
cord-007444-c9vu8ako	77	12	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	77	13	coincided	coincide	VBN
cord-007444-c9vu8ako	77	14	with	with	IN
cord-007444-c9vu8ako	77	15	reinfection	reinfection	NN
cord-007444-c9vu8ako	77	16	by	by	IN
cord-007444-c9vu8ako	77	17	strains	strain	NNS
cord-007444-c9vu8ako	77	18	of	of	IN
cord-007444-c9vu8ako	77	19	H.	h.	NN
cord-007444-c9vu8ako	77	20	influenzae	influenzae	NN
cord-007444-c9vu8ako	77	21	having	have	VBG
cord-007444-c9vu8ako	77	22	either	either	CC
cord-007444-c9vu8ako	77	23	the	the	DT
cord-007444-c9vu8ako	77	24	same	same	JJ
cord-007444-c9vu8ako	77	25	(	(	-LRB-
cord-007444-c9vu8ako	77	26	i.e.	i.e.	FW
cord-007444-c9vu8ako	77	27	,	,	,
cord-007444-c9vu8ako	77	28	endogenous	endogenous	JJ
cord-007444-c9vu8ako	77	29	)	)	-RRB-
cord-007444-c9vu8ako	77	30	or	or	CC
cord-007444-c9vu8ako	77	31	different	different	JJ
cord-007444-c9vu8ako	77	32	(	(	-LRB-
cord-007444-c9vu8ako	77	33	i.e.	i.e.	FW
cord-007444-c9vu8ako	77	34	,	,	,
cord-007444-c9vu8ako	77	35	exogenous	exogenous	JJ
cord-007444-c9vu8ako	77	36	)	)	-RRB-
cord-007444-c9vu8ako	77	37	DNA	dna	NN
cord-007444-c9vu8ako	77	38	fingerprint	fingerprint	NN
cord-007444-c9vu8ako	77	39	.	.	.
cord-007444-c9vu8ako	78	1	Strains	strain	NNS
cord-007444-c9vu8ako	78	2	of	of	IN
cord-007444-c9vu8ako	78	3	H.	h.	NN
cord-007444-c9vu8ako	78	4	influenzae	influenzae	NN
cord-007444-c9vu8ako	78	5	were	be	VBD
cord-007444-c9vu8ako	78	6	shown	show	VBN
cord-007444-c9vu8ako	78	7	to	to	TO
cord-007444-c9vu8ako	78	8	persist	persist	VB
cord-007444-c9vu8ako	78	9	for	for	IN
cord-007444-c9vu8ako	78	10	several	several	JJ
cord-007444-c9vu8ako	78	11	months	month	NNS
cord-007444-c9vu8ako	78	12	and	and	CC
cord-007444-c9vu8ako	78	13	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	78	14	treatment	treatment	NN
cord-007444-c9vu8ako	78	15	was	be	VBD
cord-007444-c9vu8ako	78	16	not	not	RB
cord-007444-c9vu8ako	78	17	effective	effective	JJ
cord-007444-c9vu8ako	78	18	in	in	IN
cord-007444-c9vu8ako	78	19	eradicating	eradicate	VBG
cord-007444-c9vu8ako	78	20	the	the	DT
cord-007444-c9vu8ako	78	21	ba	ba	NNP
cord-007444-c9vu8ako	79	1	~teria.4~	~teria.4~	NN
cord-007444-c9vu8ako	79	2	Estimates	estimate	NNS
cord-007444-c9vu8ako	79	3	of	of	IN
cord-007444-c9vu8ako	79	4	the	the	DT
cord-007444-c9vu8ako	79	5	proportion	proportion	NN
cord-007444-c9vu8ako	79	6	of	of	IN
cord-007444-c9vu8ako	79	7	COPD	COPD	NNP
cord-007444-c9vu8ako	79	8	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	79	9	associated	associate	VBN
cord-007444-c9vu8ako	79	10	with	with	IN
cord-007444-c9vu8ako	79	11	viral	viral	JJ
cord-007444-c9vu8ako	79	12	infection	infection	NN
cord-007444-c9vu8ako	79	13	range	range	NN
cord-007444-c9vu8ako	79	14	from	from	IN
cord-007444-c9vu8ako	79	15	7%117	7%117	CD
cord-007444-c9vu8ako	79	16	to	to	IN
cord-007444-c9vu8ako	79	17	63%.67	63%.67	CD
cord-007444-c9vu8ako	80	1	This	this	DT
cord-007444-c9vu8ako	80	2	large	large	JJ
cord-007444-c9vu8ako	80	3	discrepancy	discrepancy	NN
cord-007444-c9vu8ako	80	4	is	be	VBZ
cord-007444-c9vu8ako	80	5	because	because	IN
cord-007444-c9vu8ako	80	6	of	of	IN
cord-007444-c9vu8ako	80	7	significant	significant	JJ
cord-007444-c9vu8ako	80	8	differences	difference	NNS
cord-007444-c9vu8ako	80	9	in	in	IN
cord-007444-c9vu8ako	80	10	study	study	NN
cord-007444-c9vu8ako	80	11	design.25	design.25	NNP
cord-007444-c9vu8ako	80	12	Several	several	JJ
cord-007444-c9vu8ako	80	13	studies	study	NNS
cord-007444-c9vu8ako	80	14	lacked	lack	VBD
cord-007444-c9vu8ako	80	15	adequate	adequate	JJ
cord-007444-c9vu8ako	80	16	control	control	NN
cord-007444-c9vu8ako	80	17	by	by	IN
cord-007444-c9vu8ako	80	18	failing	fail	VBG
cord-007444-c9vu8ako	80	19	to	to	TO
cord-007444-c9vu8ako	80	20	record	record	VB
cord-007444-c9vu8ako	80	21	the	the	DT
cord-007444-c9vu8ako	80	22	frequency	frequency	NN
cord-007444-c9vu8ako	80	23	of	of	IN
cord-007444-c9vu8ako	80	24	viral	viral	JJ
cord-007444-c9vu8ako	80	25	infection	infection	NN
cord-007444-c9vu8ako	80	26	during	during	IN
cord-007444-c9vu8ako	81	1	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	81	2	-	-	HYPH
cord-007444-c9vu8ako	81	3	free	free	JJ
cord-007444-c9vu8ako	81	4	periods.@,75	periods.@,75	NNP
cord-007444-c9vu8ako	81	5	Others	Others	NNPS
cord-007444-c9vu8ako	81	6	,	,	,
cord-007444-c9vu8ako	81	7	such	such	JJ
cord-007444-c9vu8ako	81	8	as	as	IN
cord-007444-c9vu8ako	81	9	those	those	DT
cord-007444-c9vu8ako	81	10	by	by	IN
cord-007444-c9vu8ako	81	11	Sommerville	Sommerville	NNP
cord-007444-c9vu8ako	81	12	and	and	CC
cord-007444-c9vu8ako	81	13	Stenhouse	Stenhouse	NNP
cord-007444-c9vu8ako	81	14	,	,	,
cord-007444-c9vu8ako	81	15	l16	l16	NNP
cord-007444-c9vu8ako	81	16	,	,	,
cord-007444-c9vu8ako	81	17	118	118	CD
cord-007444-c9vu8ako	81	18	attempted	attempt	VBD
cord-007444-c9vu8ako	81	19	to	to	TO
cord-007444-c9vu8ako	81	20	detect	detect	VB
cord-007444-c9vu8ako	81	21	only	only	RB
cord-007444-c9vu8ako	81	22	selected	select	VBN
cord-007444-c9vu8ako	81	23	pathogens	pathogen	NNS
cord-007444-c9vu8ako	81	24	.	.	.
cord-007444-c9vu8ako	82	1	Variability	variability	NN
cord-007444-c9vu8ako	82	2	in	in	IN
cord-007444-c9vu8ako	82	3	the	the	DT
cord-007444-c9vu8ako	82	4	definition	definition	NN
cord-007444-c9vu8ako	82	5	of	of	IN
cord-007444-c9vu8ako	82	6	an	an	DT
cord-007444-c9vu8ako	82	7	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	82	8	is	be	VBZ
cord-007444-c9vu8ako	82	9	another	another	DT
cord-007444-c9vu8ako	82	10	factor	factor	NN
cord-007444-c9vu8ako	82	11	that	that	WDT
cord-007444-c9vu8ako	82	12	may	may	MD
cord-007444-c9vu8ako	82	13	affect	affect	VB
cord-007444-c9vu8ako	82	14	the	the	DT
cord-007444-c9vu8ako	82	15	percentage	percentage	NN
cord-007444-c9vu8ako	82	16	of	of	IN
cord-007444-c9vu8ako	82	17	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	82	18	caused	cause	VBN
cord-007444-c9vu8ako	82	19	by	by	IN
cord-007444-c9vu8ako	82	20	viral	viral	JJ
cord-007444-c9vu8ako	82	21	illness	illness	NN
cord-007444-c9vu8ako	82	22	.	.	.
cord-007444-c9vu8ako	83	1	Finally	finally	RB
cord-007444-c9vu8ako	83	2	,	,	,
cord-007444-c9vu8ako	83	3	different	different	JJ
cord-007444-c9vu8ako	83	4	serologic	serologic	NN
cord-007444-c9vu8ako	83	5	and	and	CC
cord-007444-c9vu8ako	83	6	isolation	isolation	NN
cord-007444-c9vu8ako	83	7	techniques	technique	NNS
cord-007444-c9vu8ako	83	8	account	account	VBP
cord-007444-c9vu8ako	83	9	for	for	IN
cord-007444-c9vu8ako	83	10	some	some	DT
cord-007444-c9vu8ako	83	11	of	of	IN
cord-007444-c9vu8ako	83	12	the	the	DT
cord-007444-c9vu8ako	83	13	variety	variety	NN
cord-007444-c9vu8ako	83	14	in	in	IN
cord-007444-c9vu8ako	83	15	study	study	NN
cord-007444-c9vu8ako	84	1	re	re	IN
cord-007444-c9vu8ako	84	2	~	~	NFP
cord-007444-c9vu8ako	84	3	ults.5~	ults.5~	NNP
cord-007444-c9vu8ako	84	4	The	the	DT
cord-007444-c9vu8ako	84	5	three	three	CD
cord-007444-c9vu8ako	84	6	most	most	RBS
cord-007444-c9vu8ako	84	7	rigorous	rigorous	JJ
cord-007444-c9vu8ako	84	8	studies	study	NNS
cord-007444-c9vu8ako	84	9	are	be	VBP
cord-007444-c9vu8ako	84	10	summarized	summarize	VBN
cord-007444-c9vu8ako	84	11	in	in	IN
cord-007444-c9vu8ako	84	12	Table	Table	NNP
cord-007444-c9vu8ako	84	13	2	2	CD
cord-007444-c9vu8ako	84	14	.25	.25	.
cord-007444-c9vu8ako	85	1	*	*	NFP
cord-007444-c9vu8ako	85	2	55	55	CD
cord-007444-c9vu8ako	85	3	*	*	NFP
cord-007444-c9vu8ako	85	4	113	113	CD
cord-007444-c9vu8ako	86	1	The	the	DT
cord-007444-c9vu8ako	86	2	proportion	proportion	NN
cord-007444-c9vu8ako	86	3	of	of	IN
cord-007444-c9vu8ako	86	4	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	86	5	attributed	attribute	VBN
cord-007444-c9vu8ako	86	6	to	to	IN
cord-007444-c9vu8ako	86	7	viral	viral	JJ
cord-007444-c9vu8ako	86	8	(	(	-LRB-
cord-007444-c9vu8ako	86	9	or	or	CC
cord-007444-c9vu8ako	86	10	mycoplasma	mycoplasma	NN
cord-007444-c9vu8ako	86	11	)	)	-RRB-
cord-007444-c9vu8ako	86	12	illness	illness	NN
cord-007444-c9vu8ako	86	13	ranges	range	VBZ
cord-007444-c9vu8ako	86	14	from	from	IN
cord-007444-c9vu8ako	86	15	18	18	CD
cord-007444-c9vu8ako	86	16	%	%	NN
cord-007444-c9vu8ako	86	17	to	to	IN
cord-007444-c9vu8ako	86	18	34	34	CD
cord-007444-c9vu8ako	86	19	%	%	NN
cord-007444-c9vu8ako	86	20	.	.	.
cord-007444-c9vu8ako	87	1	Influenza	Influenza	NNP
cord-007444-c9vu8ako	87	2	,	,	,
cord-007444-c9vu8ako	87	3	parainfluenza	parainfluenza	NNP
cord-007444-c9vu8ako	87	4	,	,	,
cord-007444-c9vu8ako	87	5	and	and	CC
cord-007444-c9vu8ako	87	6	coronavirus	coronavirus	NN
cord-007444-c9vu8ako	87	7	were	be	VBD
cord-007444-c9vu8ako	87	8	the	the	DT
cord-007444-c9vu8ako	87	9	most	most	RBS
cord-007444-c9vu8ako	87	10	frequent	frequent	JJ
cord-007444-c9vu8ako	87	11	pathogens	pathogen	NNS
cord-007444-c9vu8ako	87	12	to	to	TO
cord-007444-c9vu8ako	87	13	be	be	VB
cord-007444-c9vu8ako	87	14	significantly	significantly	RB
cord-007444-c9vu8ako	87	15	associated	associate	VBN
cord-007444-c9vu8ako	87	16	with	with	IN
cord-007444-c9vu8ako	87	17	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	87	18	.	.	.
cord-007444-c9vu8ako	88	1	More	more	RBR
cord-007444-c9vu8ako	88	2	recently	recently	RB
cord-007444-c9vu8ako	88	3	,	,	,
cord-007444-c9vu8ako	88	4	Goh	Goh	NNP
cord-007444-c9vu8ako	88	5	et	et	NNP
cord-007444-c9vu8ako	88	6	a	a	DT
cord-007444-c9vu8ako	88	7	P	p	NN
cord-007444-c9vu8ako	88	8	performed	perform	VBD
cord-007444-c9vu8ako	88	9	a	a	DT
cord-007444-c9vu8ako	88	10	prospective	prospective	JJ
cord-007444-c9vu8ako	88	11	etiologic	etiologic	JJ
cord-007444-c9vu8ako	88	12	study	study	NN
cord-007444-c9vu8ako	88	13	of	of	IN
cord-007444-c9vu8ako	88	14	90	90	CD
cord-007444-c9vu8ako	88	15	inpatients	inpatient	NNS
cord-007444-c9vu8ako	88	16	with	with	IN
cord-007444-c9vu8ako	88	17	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	88	18	.	.	.
cord-007444-c9vu8ako	89	1	They	-PRON-	PRP
cord-007444-c9vu8ako	89	2	collected	collect	VBD
cord-007444-c9vu8ako	89	3	paired	pair	VBN
cord-007444-c9vu8ako	89	4	sera	sera	NNP
cord-007444-c9vu8ako	89	5	for	for	IN
cord-007444-c9vu8ako	89	6	influenza	influenza	NNP
cord-007444-c9vu8ako	89	7	A	A	NNP
cord-007444-c9vu8ako	89	8	,	,	,
cord-007444-c9vu8ako	89	9	B	b	NN
cord-007444-c9vu8ako	89	10	,	,	,
cord-007444-c9vu8ako	89	11	and	and	CC
cord-007444-c9vu8ako	89	12	parainfluenza	parainfluenza	NN
cord-007444-c9vu8ako	89	13	viruses	virus	NNS
cord-007444-c9vu8ako	89	14	as	as	RB
cord-007444-c9vu8ako	89	15	well	well	RB
cord-007444-c9vu8ako	89	16	as	as	IN
cord-007444-c9vu8ako	89	17	Legionella	Legionella	NNP
cord-007444-c9vu8ako	89	18	,	,	,
cord-007444-c9vu8ako	89	19	Mycoplasma	Mycoplasma	NNP
cord-007444-c9vu8ako	89	20	,	,	,
cord-007444-c9vu8ako	89	21	and	and	CC
cord-007444-c9vu8ako	89	22	Chlamydia	Chlamydia	NNP
cord-007444-c9vu8ako	89	23	.	.	.
cord-007444-c9vu8ako	90	1	Positive	positive	JJ
cord-007444-c9vu8ako	90	2	serology	serology	NN
cord-007444-c9vu8ako	90	3	was	be	VBD
cord-007444-c9vu8ako	90	4	found	find	VBN
cord-007444-c9vu8ako	90	5	in	in	IN
cord-007444-c9vu8ako	90	6	31	31	CD
cord-007444-c9vu8ako	90	7	patients	patient	NNS
cord-007444-c9vu8ako	90	8	(	(	-LRB-
cord-007444-c9vu8ako	90	9	34	34	CD
cord-007444-c9vu8ako	90	10	%	%	NN
cord-007444-c9vu8ako	90	11	)	)	-RRB-
cord-007444-c9vu8ako	90	12	,	,	,
cord-007444-c9vu8ako	90	13	of	of	IN
cord-007444-c9vu8ako	90	14	whom	whom	WP
cord-007444-c9vu8ako	90	15	26	26	CD
cord-007444-c9vu8ako	90	16	patients	patient	NNS
cord-007444-c9vu8ako	90	17	(	(	-LRB-
cord-007444-c9vu8ako	90	18	28	28	CD
cord-007444-c9vu8ako	90	19	%	%	NN
cord-007444-c9vu8ako	90	20	)	)	-RRB-
cord-007444-c9vu8ako	90	21	had	have	VBD
cord-007444-c9vu8ako	90	22	viral	viral	JJ
cord-007444-c9vu8ako	90	23	infections	infection	NNS
cord-007444-c9vu8ako	90	24	.	.	.
cord-007444-c9vu8ako	91	1	The	the	DT
cord-007444-c9vu8ako	91	2	most	most	RBS
cord-007444-c9vu8ako	91	3	common	common	JJ
cord-007444-c9vu8ako	91	4	organism	organism	NN
cord-007444-c9vu8ako	91	5	was	be	VBD
cord-007444-c9vu8ako	91	6	influenza	influenza	NN
cord-007444-c9vu8ako	91	7	A	A	NNP
cord-007444-c9vu8ako	91	8	,	,	,
cord-007444-c9vu8ako	91	9	with	with	IN
cord-007444-c9vu8ako	91	10	18	18	CD
cord-007444-c9vu8ako	91	11	patients	patient	NNS
cord-007444-c9vu8ako	91	12	demonstrating	demonstrate	VBG
cord-007444-c9vu8ako	91	13	positive	positive	JJ
cord-007444-c9vu8ako	91	14	serology	serology	NN
cord-007444-c9vu8ako	91	15	(	(	-LRB-
cord-007444-c9vu8ako	91	16	20	20	CD
cord-007444-c9vu8ako	91	17	%	%	NN
cord-007444-c9vu8ako	91	18	)	)	-RRB-
cord-007444-c9vu8ako	91	19	.	.	.
cord-007444-c9vu8ako	92	1	Five	five	CD
cord-007444-c9vu8ako	92	2	patients	patient	NNS
cord-007444-c9vu8ako	92	3	had	have	VBD
cord-007444-c9vu8ako	92	4	positive	positive	JJ
cord-007444-c9vu8ako	92	5	serology	serology	NN
cord-007444-c9vu8ako	92	6	for	for	IN
cord-007444-c9vu8ako	92	7	Legionella	Legionella	NNP
cord-007444-c9vu8ako	92	8	,	,	,
cord-007444-c9vu8ako	92	9	whereas	whereas	IN
cord-007444-c9vu8ako	92	10	no	no	DT
cord-007444-c9vu8ako	92	11	evidence	evidence	NN
cord-007444-c9vu8ako	92	12	was	be	VBD
cord-007444-c9vu8ako	92	13	found	find	VBN
cord-007444-c9vu8ako	92	14	for	for	IN
cord-007444-c9vu8ako	92	15	infections	infection	NNS
cord-007444-c9vu8ako	92	16	caused	cause	VBN
cord-007444-c9vu8ako	92	17	by	by	IN
cord-007444-c9vu8ako	92	18	Mycoplasma	mycoplasma	NN
cord-007444-c9vu8ako	92	19	or	or	CC
cord-007444-c9vu8ako	92	20	Chlamydia.48	Chlamydia.48	NNP
cord-007444-c9vu8ako	92	21	Gump	Gump	NNP
cord-007444-c9vu8ako	92	22	et	et	FW
cord-007444-c9vu8ako	92	23	a155	a155	NNP
cord-007444-c9vu8ako	93	1	observed	observe	VBD
cord-007444-c9vu8ako	93	2	25	25	CD
cord-007444-c9vu8ako	93	3	patients	patient	NNS
cord-007444-c9vu8ako	93	4	every	every	DT
cord-007444-c9vu8ako	93	5	2	2	CD
cord-007444-c9vu8ako	93	6	weeks	week	NNS
cord-007444-c9vu8ako	93	7	for	for	IN
cord-007444-c9vu8ako	93	8	4	4	CD
cord-007444-c9vu8ako	93	9	years	year	NNS
cord-007444-c9vu8ako	93	10	and	and	CC
cord-007444-c9vu8ako	93	11	documented	document	VBD
cord-007444-c9vu8ako	93	12	116	116	CD
cord-007444-c9vu8ako	93	13	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	93	14	.	.	.
cord-007444-c9vu8ako	94	1	They	-PRON-	PRP
cord-007444-c9vu8ako	94	2	derived	derive	VBD
cord-007444-c9vu8ako	94	3	a	a	DT
cord-007444-c9vu8ako	94	4	striking	striking	JJ
cord-007444-c9vu8ako	94	5	correlation	correlation	NN
cord-007444-c9vu8ako	94	6	of	of	IN
cord-007444-c9vu8ako	94	7	infection	infection	NN
cord-007444-c9vu8ako	94	8	with	with	IN
cord-007444-c9vu8ako	94	9	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	94	10	by	by	IN
cord-007444-c9vu8ako	94	11	interpreting	interpret	VBG
cord-007444-c9vu8ako	94	12	their	-PRON-	PRP$
cord-007444-c9vu8ako	94	13	data	datum	NNS
cord-007444-c9vu8ako	94	14	in	in	IN
cord-007444-c9vu8ako	94	15	a	a	DT
cord-007444-c9vu8ako	94	16	time	time	NN
cord-007444-c9vu8ako	94	17	-	-	HYPH
cord-007444-c9vu8ako	94	18	weighted	weight	VBN
cord-007444-c9vu8ako	94	19	analysis	analysis	NN
cord-007444-c9vu8ako	94	20	.	.	.
cord-007444-c9vu8ako	95	1	They	-PRON-	PRP
cord-007444-c9vu8ako	95	2	found	find	VBD
cord-007444-c9vu8ako	95	3	that	that	IN
cord-007444-c9vu8ako	95	4	the	the	DT
cord-007444-c9vu8ako	95	5	incidence	incidence	NN
cord-007444-c9vu8ako	95	6	of	of	IN
cord-007444-c9vu8ako	95	7	infection	infection	NN
cord-007444-c9vu8ako	95	8	was	be	VBD
cord-007444-c9vu8ako	95	9	3L"/o	3l"/o	CD
cord-007444-c9vu8ako	95	10	per	per	IN
cord-007444-c9vu8ako	95	11	patient	patient	JJ
cord-007444-c9vu8ako	95	12	week	week	NN
cord-007444-c9vu8ako	95	13	of	of	IN
cord-007444-c9vu8ako	95	14	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	95	15	but	but	CC
cord-007444-c9vu8ako	95	16	only	only	RB
cord-007444-c9vu8ako	95	17	0.9	0.9	CD
cord-007444-c9vu8ako	95	18	%	%	NN
cord-007444-c9vu8ako	95	19	ver	ver	NN
cord-007444-c9vu8ako	95	20	patient	patient	JJ
cord-007444-c9vu8ako	95	21	week	week	NN
cord-007444-c9vu8ako	95	22	in	in	IN
cord-007444-c9vu8ako	95	23	remission	remission	NN
cord-007444-c9vu8ako	95	24	.	.	.
cord-007444-c9vu8ako	96	1	In	in	IN
cord-007444-c9vu8ako	96	2	their	-PRON-	PRP$
cord-007444-c9vu8ako	96	3	5-year	5-year	CD
cord-007444-c9vu8ako	96	4	aniiysis	aniiysis	NN
cord-007444-c9vu8ako	96	5	,	,	,
cord-007444-c9vu8ako	96	6	Buscho	Buscho	NNP
cord-007444-c9vu8ako	96	7	et	et	NNP
cord-007444-c9vu8ako	96	8	alZ5	alZ5	NNS
cord-007444-c9vu8ako	96	9	found	find	VBD
cord-007444-c9vu8ako	96	10	that	that	IN
cord-007444-c9vu8ako	96	11	25	25	CD
cord-007444-c9vu8ako	96	12	%	%	NN
cord-007444-c9vu8ako	96	13	of	of	IN
cord-007444-c9vu8ako	96	14	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	96	15	were	be	VBD
cord-007444-c9vu8ako	96	16	associated	associate	VBN
cord-007444-c9vu8ako	96	17	with	with	IN
cord-007444-c9vu8ako	96	18	viral	viral	JJ
cord-007444-c9vu8ako	96	19	infection	infection	NN
cord-007444-c9vu8ako	96	20	.	.	.
cord-007444-c9vu8ako	97	1	This	this	DT
cord-007444-c9vu8ako	97	2	rate	rate	NN
cord-007444-c9vu8ako	97	3	was	be	VBD
cord-007444-c9vu8ako	97	4	twice	twice	PDT
cord-007444-c9vu8ako	97	5	that	that	DT
cord-007444-c9vu8ako	97	6	of	of	IN
cord-007444-c9vu8ako	97	7	viral	viral	JJ
cord-007444-c9vu8ako	97	8	infections	infection	NNS
cord-007444-c9vu8ako	97	9	during	during	IN
cord-007444-c9vu8ako	97	10	remission	remission	NN
cord-007444-c9vu8ako	97	11	detected	detect	VBD
cord-007444-c9vu8ako	97	12	as	as	IN
cord-007444-c9vu8ako	97	13	an	an	DT
cord-007444-c9vu8ako	97	14	asymptomatic	asymptomatic	JJ
cord-007444-c9vu8ako	97	15	fourfold	fourfold	JJ
cord-007444-c9vu8ako	97	16	rise	rise	NN
cord-007444-c9vu8ako	97	17	in	in	IN
cord-007444-c9vu8ako	97	18	antiviral	antiviral	JJ
cord-007444-c9vu8ako	97	19	antibody	antibody	NN
cord-007444-c9vu8ako	97	20	titers	titer	NNS
cord-007444-c9vu8ako	97	21	.	.	.
cord-007444-c9vu8ako	98	1	In	in	IN
cord-007444-c9vu8ako	98	2	the	the	DT
cord-007444-c9vu8ako	98	3	largest	large	JJS
cord-007444-c9vu8ako	98	4	study	study	NN
cord-007444-c9vu8ako	98	5	,	,	,
cord-007444-c9vu8ako	98	6	Smith	Smith	NNP
cord-007444-c9vu8ako	98	7	et	et	NNP
cord-007444-c9vu8ako	98	8	aP3	ap3	DT
cord-007444-c9vu8ako	98	9	followed	follow	VBD
cord-007444-c9vu8ako	98	10	150	150	CD
cord-007444-c9vu8ako	98	11	patients	patient	NNS
cord-007444-c9vu8ako	98	12	over	over	IN
cord-007444-c9vu8ako	98	13	8	8	CD
cord-007444-c9vu8ako	98	14	years	year	NNS
cord-007444-c9vu8ako	98	15	and	and	CC
cord-007444-c9vu8ako	98	16	analyzed	analyze	VBD
cord-007444-c9vu8ako	98	17	more	more	JJR
cord-007444-c9vu8ako	98	18	than	than	IN
cord-007444-c9vu8ako	98	19	1000	1000	CD
cord-007444-c9vu8ako	98	20	acute	acute	JJ
cord-007444-c9vu8ako	98	21	respiratory	respiratory	JJ
cord-007444-c9vu8ako	98	22	illnesses	illness	NNS
cord-007444-c9vu8ako	98	23	.	.	.
cord-007444-c9vu8ako	99	1	They	-PRON-	PRP
cord-007444-c9vu8ako	99	2	associated	associate	VBD
cord-007444-c9vu8ako	99	3	nonbacterial	nonbacterial	JJ
cord-007444-c9vu8ako	99	4	infections	infection	NNS
cord-007444-c9vu8ako	99	5	with	with	IN
cord-007444-c9vu8ako	99	6	approximately	approximately	RB
cord-007444-c9vu8ako	99	7	20	20	CD
cord-007444-c9vu8ako	99	8	%	%	NN
cord-007444-c9vu8ako	99	9	of	of	IN
cord-007444-c9vu8ako	99	10	acute	acute	JJ
cord-007444-c9vu8ako	99	11	respiratory	respiratory	JJ
cord-007444-c9vu8ako	99	12	illnesses	illness	NNS
cord-007444-c9vu8ako	99	13	but	but	CC
cord-007444-c9vu8ako	99	14	only	only	RB
cord-007444-c9vu8ako	99	15	6	6	CD
cord-007444-c9vu8ako	99	16	%	%	NN
cord-007444-c9vu8ako	99	17	of	of	IN
cord-007444-c9vu8ako	99	18	illnessfree	illnessfree	JJ
cord-007444-c9vu8ako	99	19	periods	period	NNS
cord-007444-c9vu8ako	99	20	.	.	.
cord-007444-c9vu8ako	100	1	In	in	IN
cord-007444-c9vu8ako	100	2	contrast	contrast	NN
cord-007444-c9vu8ako	100	3	with	with	IN
cord-007444-c9vu8ako	100	4	the	the	DT
cord-007444-c9vu8ako	100	5	work	work	NN
cord-007444-c9vu8ako	100	6	by	by	IN
cord-007444-c9vu8ako	100	7	Buscho	Buscho	NNP
cord-007444-c9vu8ako	100	8	and	and	CC
cord-007444-c9vu8ako	100	9	Gump	Gump	NNP
cord-007444-c9vu8ako	100	10	,	,	,
cord-007444-c9vu8ako	100	11	Smith	Smith	NNP
cord-007444-c9vu8ako	100	12	et	et	NNP
cord-007444-c9vu8ako	100	13	noted	note	VBD
cord-007444-c9vu8ako	100	14	a	a	DT
cord-007444-c9vu8ako	100	15	high	high	JJ
cord-007444-c9vu8ako	100	16	rate	rate	NN
cord-007444-c9vu8ako	100	17	of	of	IN
cord-007444-c9vu8ako	100	18	rhinoviral	rhinoviral	JJ
cord-007444-c9vu8ako	100	19	infection	infection	NN
cord-007444-c9vu8ako	100	20	.	.	.
cord-007444-c9vu8ako	101	1	Uncontrolled	uncontrolled	JJ
cord-007444-c9vu8ako	101	2	studies	study	NNS
cord-007444-c9vu8ako	101	3	by	by	IN
cord-007444-c9vu8ako	101	4	McNamara	McNamara	NNP
cord-007444-c9vu8ako	101	5	and	and	CC
cord-007444-c9vu8ako	101	6	Eadie4	Eadie4	NNP
cord-007444-c9vu8ako	101	7	,	,	,
cord-007444-c9vu8ako	101	8	,	,	,
cord-007444-c9vu8ako	101	9	75	75	CD
cord-007444-c9vu8ako	101	10	also	also	RB
cord-007444-c9vu8ako	101	11	reported	report	VBD
cord-007444-c9vu8ako	101	12	rhinoviral	rhinoviral	JJ
cord-007444-c9vu8ako	101	13	infections	infection	NNS
cord-007444-c9vu8ako	101	14	to	to	TO
cord-007444-c9vu8ako	101	15	be	be	VB
cord-007444-c9vu8ako	101	16	associated	associate	VBN
cord-007444-c9vu8ako	101	17	with	with	IN
cord-007444-c9vu8ako	101	18	COPD	COPD	NNP
cord-007444-c9vu8ako	101	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	101	20	in	in	IN
cord-007444-c9vu8ako	101	21	43	43	CD
cord-007444-c9vu8ako	101	22	%	%	NN
cord-007444-c9vu8ako	101	23	and	and	CC
cord-007444-c9vu8ako	101	24	20	20	CD
cord-007444-c9vu8ako	101	25	%	%	NN
cord-007444-c9vu8ako	101	26	of	of	IN
cord-007444-c9vu8ako	101	27	cases	case	NNS
cord-007444-c9vu8ako	101	28	,	,	,
cord-007444-c9vu8ako	101	29	respectively	respectively	RB
cord-007444-c9vu8ako	101	30	.	.	.
cord-007444-c9vu8ako	102	1	Common	common	JJ
cord-007444-c9vu8ako	102	2	colds	cold	NNS
cord-007444-c9vu8ako	102	3	may	may	MD
cord-007444-c9vu8ako	102	4	have	have	VB
cord-007444-c9vu8ako	102	5	a	a	DT
cord-007444-c9vu8ako	102	6	deleterious	deleterious	JJ
cord-007444-c9vu8ako	102	7	effect	effect	NN
cord-007444-c9vu8ako	102	8	upon	upon	IN
cord-007444-c9vu8ako	102	9	lung	lung	NN
cord-007444-c9vu8ako	102	10	functionz9	functionz9	NN
cord-007444-c9vu8ako	102	11	and	and	CC
cord-007444-c9vu8ako	102	12	patients	patient	NNS
cord-007444-c9vu8ako	102	13	with	with	IN
cord-007444-c9vu8ako	102	14	COPD	COPD	NNP
cord-007444-c9vu8ako	102	15	are	be	VBP
cord-007444-c9vu8ako	102	16	more	more	RBR
cord-007444-c9vu8ako	102	17	likely	likely	JJ
cord-007444-c9vu8ako	102	18	to	to	TO
cord-007444-c9vu8ako	102	19	develop	develop	VB
cord-007444-c9vu8ako	102	20	increased	increase	VBN
cord-007444-c9vu8ako	102	21	cough	cough	NN
cord-007444-c9vu8ako	102	22	and	and	CC
cord-007444-c9vu8ako	102	23	lower	low	JJR
cord-007444-c9vu8ako	102	24	respiratory	respiratory	JJ
cord-007444-c9vu8ako	102	25	tract	tract	NN
cord-007444-c9vu8ako	102	26	symptoms	symptom	NNS
cord-007444-c9vu8ako	102	27	during	during	IN
cord-007444-c9vu8ako	102	28	rhinoviral	rhinoviral	JJ
cord-007444-c9vu8ako	102	29	infections	infection	NNS
cord-007444-c9vu8ako	102	30	than	than	IN
cord-007444-c9vu8ako	102	31	healthy	healthy	JJ
cord-007444-c9vu8ako	102	32	113	113	CD
cord-007444-c9vu8ako	102	33	Smith	Smith	NNP
cord-007444-c9vu8ako	102	34	et	et	NNP
cord-007444-c9vu8ako	102	35	aPz	aPz	NNP
cord-007444-c9vu8ako	102	36	performed	perform	VBD
cord-007444-c9vu8ako	102	37	a	a	DT
cord-007444-c9vu8ako	102	38	7-year	7-year	JJ
cord-007444-c9vu8ako	102	39	observational	observational	JJ
cord-007444-c9vu8ako	102	40	study	study	NN
cord-007444-c9vu8ako	102	41	of	of	IN
cord-007444-c9vu8ako	102	42	120	120	CD
cord-007444-c9vu8ako	102	43	patients	patient	NNS
cord-007444-c9vu8ako	102	44	to	to	TO
cord-007444-c9vu8ako	102	45	assess	assess	VB
cord-007444-c9vu8ako	102	46	potential	potential	JJ
cord-007444-c9vu8ako	102	47	interactions	interaction	NNS
cord-007444-c9vu8ako	102	48	between	between	IN
cord-007444-c9vu8ako	102	49	viral	viral	JJ
cord-007444-c9vu8ako	102	50	,	,	,
cord-007444-c9vu8ako	102	51	mycoplasmal	mycoplasmal	JJ
cord-007444-c9vu8ako	102	52	,	,	,
cord-007444-c9vu8ako	102	53	and	and	CC
cord-007444-c9vu8ako	102	54	bacterial	bacterial	JJ
cord-007444-c9vu8ako	102	55	infections	infection	NNS
cord-007444-c9vu8ako	102	56	in	in	IN
cord-007444-c9vu8ako	102	57	patients	patient	NNS
cord-007444-c9vu8ako	102	58	with	with	IN
cord-007444-c9vu8ako	102	59	COPD	COPD	NNP
cord-007444-c9vu8ako	102	60	.	.	.
cord-007444-c9vu8ako	103	1	They	-PRON-	PRP
cord-007444-c9vu8ako	103	2	calculated	calculate	VBD
cord-007444-c9vu8ako	103	3	the	the	DT
cord-007444-c9vu8ako	103	4	ratio	ratio	NN
cord-007444-c9vu8ako	103	5	of	of	IN
cord-007444-c9vu8ako	103	6	number	number	NN
cord-007444-c9vu8ako	103	7	of	of	IN
cord-007444-c9vu8ako	103	8	observed	observed	JJ
cord-007444-c9vu8ako	103	9	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	103	10	to	to	IN
cord-007444-c9vu8ako	103	11	number	number	NN
cord-007444-c9vu8ako	103	12	of	of	IN
cord-007444-c9vu8ako	103	13	expected	expect	VBN
cord-007444-c9vu8ako	103	14	viral	viral	JJ
cord-007444-c9vu8ako	103	15	or	or	CC
cord-007444-c9vu8ako	103	16	bacterial	bacterial	JJ
cord-007444-c9vu8ako	103	17	associations	association	NNS
cord-007444-c9vu8ako	103	18	.	.	.
cord-007444-c9vu8ako	104	1	Haemophilus	haemophilus	JJ
cord-007444-c9vu8ako	104	2	influenzae	influenzae	NN
cord-007444-c9vu8ako	104	3	and	and	CC
cord-007444-c9vu8ako	104	4	S.	S.	NNP
cord-007444-c9vu8ako	104	5	pneumoniae	pneumoniae	NNS
cord-007444-c9vu8ako	104	6	were	be	VBD
cord-007444-c9vu8ako	104	7	isolated	isolate	VBN
cord-007444-c9vu8ako	104	8	more	more	JJR
cord-007444-c9vu8ako	104	9	than	than	IN
cord-007444-c9vu8ako	104	10	twice	twice	RB
cord-007444-c9vu8ako	104	11	as	as	RB
cord-007444-c9vu8ako	104	12	often	often	RB
cord-007444-c9vu8ako	104	13	as	as	IN
cord-007444-c9vu8ako	104	14	expected	expect	VBN
cord-007444-c9vu8ako	104	15	following	follow	VBG
cord-007444-c9vu8ako	104	16	influenza	influenza	NN
cord-007444-c9vu8ako	104	17	virus	virus	NN
cord-007444-c9vu8ako	104	18	infection	infection	NN
cord-007444-c9vu8ako	104	19	.	.	.
cord-007444-c9vu8ako	105	1	Marked	marked	JJ
cord-007444-c9vu8ako	105	2	rises	rise	NNS
cord-007444-c9vu8ako	105	3	in	in	IN
cord-007444-c9vu8ako	105	4	titers	titer	NNS
cord-007444-c9vu8ako	105	5	of	of	IN
cord-007444-c9vu8ako	105	6	antibodies	antibody	NNS
cord-007444-c9vu8ako	105	7	against	against	IN
cord-007444-c9vu8ako	105	8	H.	H.	NNP
cord-007444-c9vu8ako	105	9	influenzae	influenzae	NN
cord-007444-c9vu8ako	105	10	were	be	VBD
cord-007444-c9vu8ako	105	11	associated	associate	VBN
cord-007444-c9vu8ako	105	12	with	with	IN
cord-007444-c9vu8ako	105	13	preceding	precede	VBG
cord-007444-c9vu8ako	105	14	viral	viral	JJ
cord-007444-c9vu8ako	105	15	or	or	CC
cord-007444-c9vu8ako	105	16	Mycoplasma	mycoplasma	NN
cord-007444-c9vu8ako	105	17	infections	infection	NNS
cord-007444-c9vu8ako	105	18	,	,	,
cord-007444-c9vu8ako	105	19	suggesting	suggest	VBG
cord-007444-c9vu8ako	105	20	that	that	IN
cord-007444-c9vu8ako	105	21	viral	viral	JJ
cord-007444-c9vu8ako	105	22	infection	infection	NN
cord-007444-c9vu8ako	105	23	promotes	promote	VBZ
cord-007444-c9vu8ako	105	24	increased	increase	VBN
cord-007444-c9vu8ako	105	25	invasiveness	invasiveness	NN
cord-007444-c9vu8ako	105	26	of	of	IN
cord-007444-c9vu8ako	105	27	H.	h.	NN
cord-007444-c9vu8ako	105	28	influenzae	influenzae	NN
cord-007444-c9vu8ako	105	29	and	and	CC
cord-007444-c9vu8ako	105	30	subsequent	subsequent	JJ
cord-007444-c9vu8ako	105	31	infection	infection	NN
cord-007444-c9vu8ako	105	32	.	.	.
cord-007444-c9vu8ako	106	1	There	there	EX
cord-007444-c9vu8ako	106	2	are	be	VBP
cord-007444-c9vu8ako	106	3	no	no	DT
cord-007444-c9vu8ako	106	4	other	other	JJ
cord-007444-c9vu8ako	106	5	rigorously	rigorously	RB
cord-007444-c9vu8ako	106	6	performed	perform	VBN
cord-007444-c9vu8ako	106	7	clinical	clinical	JJ
cord-007444-c9vu8ako	106	8	studies	study	NNS
cord-007444-c9vu8ako	106	9	of	of	IN
cord-007444-c9vu8ako	106	10	the	the	DT
cord-007444-c9vu8ako	106	11	interaction	interaction	NN
cord-007444-c9vu8ako	106	12	between	between	IN
cord-007444-c9vu8ako	106	13	viral	viral	JJ
cord-007444-c9vu8ako	106	14	and	and	CC
cord-007444-c9vu8ako	106	15	bacterial	bacterial	JJ
cord-007444-c9vu8ako	106	16	infections	infection	NNS
cord-007444-c9vu8ako	106	17	in	in	IN
cord-007444-c9vu8ako	106	18	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	106	19	.	.	.
cord-007444-c9vu8ako	107	1	Although	although	IN
cord-007444-c9vu8ako	107	2	the	the	DT
cord-007444-c9vu8ako	107	3	concept	concept	NN
cord-007444-c9vu8ako	107	4	that	that	WDT
cord-007444-c9vu8ako	107	5	viruses	virus	NNS
cord-007444-c9vu8ako	107	6	promote	promote	VBP
cord-007444-c9vu8ako	107	7	secondary	secondary	JJ
cord-007444-c9vu8ako	107	8	bacterial	bacterial	JJ
cord-007444-c9vu8ako	107	9	infection	infection	NN
cord-007444-c9vu8ako	107	10	seems	seem	VBZ
cord-007444-c9vu8ako	107	11	biologically	biologically	RB
cord-007444-c9vu8ako	107	12	plausible	plausible	JJ
cord-007444-c9vu8ako	107	13	and	and	CC
cord-007444-c9vu8ako	107	14	is	be	VBZ
cord-007444-c9vu8ako	107	15	supported	support	VBN
cord-007444-c9vu8ako	107	16	by	by	IN
cord-007444-c9vu8ako	107	17	animal	animal	NN
cord-007444-c9vu8ako	107	18	research	research	NN
cord-007444-c9vu8ako	107	19	,	,	,
cord-007444-c9vu8ako	107	20	it	-PRON-	PRP
cord-007444-c9vu8ako	107	21	remains	remain	VBZ
cord-007444-c9vu8ako	107	22	unknown	unknown	JJ
cord-007444-c9vu8ako	107	23	how	how	WRB
cord-007444-c9vu8ako	107	24	often	often	RB
cord-007444-c9vu8ako	107	25	bacterial	bacterial	JJ
cord-007444-c9vu8ako	107	26	infection	infection	NN
cord-007444-c9vu8ako	107	27	in	in	IN
cord-007444-c9vu8ako	107	28	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	107	29	follows	follow	VBZ
cord-007444-c9vu8ako	107	30	an	an	DT
cord-007444-c9vu8ako	107	31	inciting	incite	VBG
cord-007444-c9vu8ako	107	32	viral	viral	JJ
cord-007444-c9vu8ako	107	33	infection	infection	NN
cord-007444-c9vu8ako	107	34	.	.	.
cord-007444-c9vu8ako	108	1	Suspended	suspend	VBN
cord-007444-c9vu8ako	108	2	particulate	particulate	NN
cord-007444-c9vu8ako	108	3	matter	matter	NN
cord-007444-c9vu8ako	108	4	less	less	JJR
cord-007444-c9vu8ako	108	5	than	than	IN
cord-007444-c9vu8ako	108	6	10	10	CD
cord-007444-c9vu8ako	108	7	pm	pm	NN
cord-007444-c9vu8ako	108	8	in	in	IN
cord-007444-c9vu8ako	108	9	diameter	diameter	NN
cord-007444-c9vu8ako	108	10	@'MI	@'MI	.
cord-007444-c9vu8ako	109	1	")	")	``
cord-007444-c9vu8ako	109	2	is	be	VBZ
cord-007444-c9vu8ako	109	3	produced	produce	VBN
cord-007444-c9vu8ako	109	4	by	by	IN
cord-007444-c9vu8ako	109	5	vehicle	vehicle	NN
cord-007444-c9vu8ako	109	6	exhaust	exhaust	NN
cord-007444-c9vu8ako	109	7	and	and	CC
cord-007444-c9vu8ako	109	8	many	many	JJ
cord-007444-c9vu8ako	109	9	industrial	industrial	JJ
cord-007444-c9vu8ako	109	10	processes	process	NNS
cord-007444-c9vu8ako	109	11	.	.	.
cord-007444-c9vu8ako	110	1	Several	several	JJ
cord-007444-c9vu8ako	110	2	epidemiologic	epidemiologic	JJ
cord-007444-c9vu8ako	110	3	studies	study	NNS
cord-007444-c9vu8ako	110	4	*	*	NFP
cord-007444-c9vu8ako	110	5	,	,	,
cord-007444-c9vu8ako	110	6	have	have	VBP
cord-007444-c9vu8ako	110	7	associated	associate	VBN
cord-007444-c9vu8ako	110	8	elevated	elevated	JJ
cord-007444-c9vu8ako	110	9	PM	pm	NN
cord-007444-c9vu8ako	110	10	,	,	,
cord-007444-c9vu8ako	110	11	,	,	,
cord-007444-c9vu8ako	110	12	levels	level	NNS
cord-007444-c9vu8ako	110	13	with	with	IN
cord-007444-c9vu8ako	110	14	a	a	DT
cord-007444-c9vu8ako	110	15	wide	wide	JJ
cord-007444-c9vu8ako	110	16	range	range	NN
cord-007444-c9vu8ako	110	17	of	of	IN
cord-007444-c9vu8ako	110	18	respiratory	respiratory	JJ
cord-007444-c9vu8ako	110	19	outcomes	outcome	NNS
cord-007444-c9vu8ako	110	20	,	,	,
cord-007444-c9vu8ako	110	21	including	include	VBG
cord-007444-c9vu8ako	110	22	reduced	reduce	VBN
cord-007444-c9vu8ako	110	23	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	110	24	function	function	NN
cord-007444-c9vu8ako	110	25	and	and	CC
cord-007444-c9vu8ako	110	26	increased	increase	VBN
cord-007444-c9vu8ako	110	27	chronic	chronic	JJ
cord-007444-c9vu8ako	110	28	respiratory	respiratory	JJ
cord-007444-c9vu8ako	110	29	symptoms	symptom	NNS
cord-007444-c9vu8ako	110	30	,	,	,
cord-007444-c9vu8ako	110	31	rates	rate	NNS
cord-007444-c9vu8ako	110	32	of	of	IN
cord-007444-c9vu8ako	110	33	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	110	34	,	,	,
cord-007444-c9vu8ako	110	35	and	and	CC
cord-007444-c9vu8ako	110	36	mortality	mortality	NN
cord-007444-c9vu8ako	110	37	.	.	.
cord-007444-c9vu8ako	111	1	Similar	similar	JJ
cord-007444-c9vu8ako	111	2	associations	association	NNS
cord-007444-c9vu8ako	111	3	exist	exist	VBP
cord-007444-c9vu8ako	111	4	for	for	IN
cord-007444-c9vu8ako	111	5	other	other	JJ
cord-007444-c9vu8ako	111	6	pollutants	pollutant	NNS
cord-007444-c9vu8ako	111	7	,	,	,
cord-007444-c9vu8ako	111	8	notably	notably	RB
cord-007444-c9vu8ako	111	9	sulfur	sulfur	NN
cord-007444-c9vu8ako	111	10	dioxide	dioxide	NN
cord-007444-c9vu8ako	111	11	(	(	-LRB-
cord-007444-c9vu8ako	111	12	SO	so	RB
cord-007444-c9vu8ako	111	13	,	,	,
cord-007444-c9vu8ako	111	14	)	)	-RRB-
cord-007444-c9vu8ako	111	15	and	and	CC
cord-007444-c9vu8ako	111	16	nitrogen	nitrogen	NN
cord-007444-c9vu8ako	111	17	dioxide	dioxide	NN
cord-007444-c9vu8ako	111	18	.	.	.
cord-007444-c9vu8ako	112	1	A	a	DT
cord-007444-c9vu8ako	112	2	5-year	5-year	CD
cord-007444-c9vu8ako	112	3	study	study	NN
cord-007444-c9vu8ako	112	4	in	in	IN
cord-007444-c9vu8ako	112	5	Bar	bar	NN
cord-007444-c9vu8ako	112	6	-	-	HYPH
cord-007444-c9vu8ako	112	7	celona121	celona121	NNP
cord-007444-c9vu8ako	112	8	reported	report	VBD
cord-007444-c9vu8ako	112	9	that	that	IN
cord-007444-c9vu8ako	112	10	small	small	JJ
cord-007444-c9vu8ako	112	11	increases	increase	NNS
cord-007444-c9vu8ako	112	12	of	of	IN
cord-007444-c9vu8ako	112	13	SO	so	RB
cord-007444-c9vu8ako	112	14	,	,	,
cord-007444-c9vu8ako	112	15	and	and	CC
cord-007444-c9vu8ako	112	16	airborne	airborne	JJ
cord-007444-c9vu8ako	112	17	particles	particle	NNS
cord-007444-c9vu8ako	112	18	produced	produce	VBD
cord-007444-c9vu8ako	112	19	adjusted	adjust	VBN
cord-007444-c9vu8ako	112	20	increases	increase	NNS
cord-007444-c9vu8ako	112	21	of	of	IN
cord-007444-c9vu8ako	112	22	6	6	CD
cord-007444-c9vu8ako	112	23	%	%	NN
cord-007444-c9vu8ako	112	24	in	in	IN
cord-007444-c9vu8ako	112	25	emergency	emergency	NN
cord-007444-c9vu8ako	112	26	room	room	NN
cord-007444-c9vu8ako	112	27	admissions	admission	NNS
cord-007444-c9vu8ako	112	28	for	for	IN
cord-007444-c9vu8ako	112	29	COPD	COPD	NNP
cord-007444-c9vu8ako	112	30	in	in	IN
cord-007444-c9vu8ako	112	31	winter	winter	NN
cord-007444-c9vu8ako	112	32	and	and	CC
cord-007444-c9vu8ako	112	33	9	9	CD
cord-007444-c9vu8ako	112	34	%	%	NN
cord-007444-c9vu8ako	112	35	in	in	IN
cord-007444-c9vu8ako	112	36	summer	summer	NN
cord-007444-c9vu8ako	112	37	.	.	.
cord-007444-c9vu8ako	113	1	Similar	similar	JJ
cord-007444-c9vu8ako	113	2	rates	rate	NNS
cord-007444-c9vu8ako	113	3	of	of	IN
cord-007444-c9vu8ako	113	4	excess	excess	JJ
cord-007444-c9vu8ako	113	5	hospitalizations	hospitalization	NNS
cord-007444-c9vu8ako	113	6	for	for	IN
cord-007444-c9vu8ako	113	7	COPD	COPD	NNP
cord-007444-c9vu8ako	113	8	have	have	VBP
cord-007444-c9vu8ako	113	9	been	be	VBN
cord-007444-c9vu8ako	113	10	reported	report	VBN
cord-007444-c9vu8ako	113	11	from	from	IN
cord-007444-c9vu8ako	113	12	Sydney	Sydney	NNP
cord-007444-c9vu8ako	113	13	,	,	,
cord-007444-c9vu8ako	113	14	Australia	Australia	NNP
cord-007444-c9vu8ako	113	15	(	(	-LRB-
cord-007444-c9vu8ako	113	16	4	4	CD
cord-007444-c9vu8ako	113	17	%	%	NN
cord-007444-c9vu8ako	113	18	)	)	-RRB-
cord-007444-c9vu8ako	113	19	;	;	:
cord-007444-c9vu8ako	113	20	Detroit	Detroit	NNP
cord-007444-c9vu8ako	113	21	,	,	,
cord-007444-c9vu8ako	113	22	Michigan	Michigan	NNP
cord-007444-c9vu8ako	113	23	(	(	-LRB-
cord-007444-c9vu8ako	113	24	6	6	CD
cord-007444-c9vu8ako	113	25	%	%	NN
cord-007444-c9vu8ako	113	26	)	)	-RRB-
cord-007444-c9vu8ako	113	27	;	;	:
cord-007444-c9vu8ako	113	28	and	and	CC
cord-007444-c9vu8ako	113	29	Birmingham	Birmingham	NNP
cord-007444-c9vu8ako	113	30	,	,	,
cord-007444-c9vu8ako	113	31	Alabama	Alabama	NNP
cord-007444-c9vu8ako	113	32	(	(	-LRB-
cord-007444-c9vu8ako	113	33	7	7	CD
cord-007444-c9vu8ako	113	34	%	%	NN
cord-007444-c9vu8ako	113	35	)	)	-RRB-
cord-007444-c9vu8ako	113	36	.	.	.
cord-007444-c9vu8ako	114	1	*	*	NFP
cord-007444-c9vu8ako	114	2	'	'	''
cord-007444-c9vu8ako	114	3	,	,	,
cord-007444-c9vu8ako	114	4	'	'	''
cord-007444-c9vu8ako	114	5	06	06	CD
cord-007444-c9vu8ako	115	1	Although	although	IN
cord-007444-c9vu8ako	115	2	small	small	JJ
cord-007444-c9vu8ako	115	3	,	,	,
cord-007444-c9vu8ako	115	4	these	these	DT
cord-007444-c9vu8ako	115	5	effects	effect	NNS
cord-007444-c9vu8ako	115	6	represent	represent	VBP
cord-007444-c9vu8ako	115	7	a	a	DT
cord-007444-c9vu8ako	115	8	significant	significant	JJ
cord-007444-c9vu8ako	115	9	public	public	JJ
cord-007444-c9vu8ako	115	10	health	health	NN
cord-007444-c9vu8ako	115	11	concern	concern	NN
cord-007444-c9vu8ako	115	12	,	,	,
cord-007444-c9vu8ako	115	13	particularly	particularly	RB
cord-007444-c9vu8ako	115	14	because	because	IN
cord-007444-c9vu8ako	115	15	they	-PRON-	PRP
cord-007444-c9vu8ako	115	16	are	be	VBP
cord-007444-c9vu8ako	115	17	demonstrable	demonstrable	JJ
cord-007444-c9vu8ako	115	18	at	at	IN
cord-007444-c9vu8ako	115	19	pollution	pollution	NN
cord-007444-c9vu8ako	115	20	levels	level	NNS
cord-007444-c9vu8ako	115	21	below	below	IN
cord-007444-c9vu8ako	115	22	current	current	JJ
cord-007444-c9vu8ako	115	23	air	air	NN
cord-007444-c9vu8ako	115	24	-	-	HYPH
cord-007444-c9vu8ako	115	25	quality	quality	NN
cord-007444-c9vu8ako	115	26	standards	standard	NNS
cord-007444-c9vu8ako	115	27	.	.	.
cord-007444-c9vu8ako	116	1	In	in	IN
cord-007444-c9vu8ako	116	2	summary	summary	NN
cord-007444-c9vu8ako	116	3	,	,	,
cord-007444-c9vu8ako	116	4	the	the	DT
cord-007444-c9vu8ako	116	5	foregoing	forego	VBG
cord-007444-c9vu8ako	116	6	studies	study	NNS
cord-007444-c9vu8ako	116	7	imply	imply	VBP
cord-007444-c9vu8ako	116	8	that	that	IN
cord-007444-c9vu8ako	116	9	bacterial	bacterial	JJ
cord-007444-c9vu8ako	116	10	pathogens	pathogen	NNS
cord-007444-c9vu8ako	116	11	can	can	MD
cord-007444-c9vu8ako	116	12	be	be	VB
cord-007444-c9vu8ako	116	13	identified	identify	VBN
cord-007444-c9vu8ako	116	14	in	in	IN
cord-007444-c9vu8ako	116	15	approximately	approximately	RB
cord-007444-c9vu8ako	116	16	half	half	NN
cord-007444-c9vu8ako	116	17	of	of	IN
cord-007444-c9vu8ako	116	18	COPD	COPD	NNP
cord-007444-c9vu8ako	116	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	116	20	.	.	.
cord-007444-c9vu8ako	117	1	Viral	viral	JJ
cord-007444-c9vu8ako	117	2	pathogens	pathogen	NNS
cord-007444-c9vu8ako	117	3	are	be	VBP
cord-007444-c9vu8ako	117	4	identifiable	identifiable	JJ
cord-007444-c9vu8ako	117	5	in	in	IN
cord-007444-c9vu8ako	117	6	about	about	RB
cord-007444-c9vu8ako	117	7	25	25	CD
cord-007444-c9vu8ako	117	8	%	%	NN
cord-007444-c9vu8ako	117	9	of	of	IN
cord-007444-c9vu8ako	117	10	such	such	JJ
cord-007444-c9vu8ako	117	11	episodes	episode	NNS
cord-007444-c9vu8ako	117	12	.	.	.
cord-007444-c9vu8ako	118	1	Poor	poor	JJ
cord-007444-c9vu8ako	118	2	air	air	NN
cord-007444-c9vu8ako	118	3	quality	quality	NN
cord-007444-c9vu8ako	118	4	may	may	MD
cord-007444-c9vu8ako	118	5	account	account	VB
cord-007444-c9vu8ako	118	6	for	for	IN
cord-007444-c9vu8ako	118	7	slightly	slightly	RB
cord-007444-c9vu8ako	118	8	more	more	JJR
cord-007444-c9vu8ako	118	9	than	than	IN
cord-007444-c9vu8ako	118	10	5	5	CD
cord-007444-c9vu8ako	118	11	%	%	NN
cord-007444-c9vu8ako	118	12	of	of	IN
cord-007444-c9vu8ako	118	13	episodes	episode	NNS
cord-007444-c9vu8ako	118	14	of	of	IN
cord-007444-c9vu8ako	118	15	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	118	16	.	.	.
cord-007444-c9vu8ako	119	1	In	in	IN
cord-007444-c9vu8ako	119	2	many	many	JJ
cord-007444-c9vu8ako	119	3	COPD	COPD	NNP
cord-007444-c9vu8ako	119	4	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	119	5	,	,	,
cord-007444-c9vu8ako	119	6	no	no	DT
cord-007444-c9vu8ako	119	7	obvious	obvious	JJ
cord-007444-c9vu8ako	119	8	pathogen	pathogen	NN
cord-007444-c9vu8ako	119	9	or	or	CC
cord-007444-c9vu8ako	119	10	precipitating	precipitate	VBG
cord-007444-c9vu8ako	119	11	cause	cause	NN
cord-007444-c9vu8ako	119	12	is	be	VBZ
cord-007444-c9vu8ako	119	13	found	find	VBN
cord-007444-c9vu8ako	119	14	.	.	.
cord-007444-c9vu8ako	120	1	It	-PRON-	PRP
cord-007444-c9vu8ako	120	2	is	be	VBZ
cord-007444-c9vu8ako	120	3	not	not	RB
cord-007444-c9vu8ako	120	4	known	know	VBN
cord-007444-c9vu8ako	120	5	how	how	WRB
cord-007444-c9vu8ako	120	6	frequently	frequently	RB
cord-007444-c9vu8ako	120	7	other	other	JJ
cord-007444-c9vu8ako	120	8	potential	potential	JJ
cord-007444-c9vu8ako	120	9	factors	factor	NNS
cord-007444-c9vu8ako	120	10	,	,	,
cord-007444-c9vu8ako	120	11	such	such	JJ
cord-007444-c9vu8ako	120	12	as	as	IN
cord-007444-c9vu8ako	120	13	medication	medication	NN
cord-007444-c9vu8ako	120	14	noncompliance	noncompliance	NN
cord-007444-c9vu8ako	120	15	or	or	CC
cord-007444-c9vu8ako	120	16	coincidental	coincidental	JJ
cord-007444-c9vu8ako	120	17	events	event	NNS
cord-007444-c9vu8ako	120	18	such	such	JJ
cord-007444-c9vu8ako	120	19	as	as	IN
cord-007444-c9vu8ako	120	20	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	120	21	embolism	embolism	NN
cord-007444-c9vu8ako	120	22	and	and	CC
cord-007444-c9vu8ako	120	23	myocardial	myocardial	JJ
cord-007444-c9vu8ako	120	24	infarction	infarction	NN
cord-007444-c9vu8ako	120	25	,	,	,
cord-007444-c9vu8ako	120	26	play	play	VB
cord-007444-c9vu8ako	120	27	an	an	DT
cord-007444-c9vu8ako	120	28	inciting	incite	VBG
cord-007444-c9vu8ako	120	29	role	role	NN
cord-007444-c9vu8ako	120	30	in	in	IN
cord-007444-c9vu8ako	120	31	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	120	32	.	.	.
cord-007444-c9vu8ako	121	1	Indeed	indeed	RB
cord-007444-c9vu8ako	121	2	,	,	,
cord-007444-c9vu8ako	121	3	it	-PRON-	PRP
cord-007444-c9vu8ako	121	4	is	be	VBZ
cord-007444-c9vu8ako	121	5	often	often	RB
cord-007444-c9vu8ako	121	6	difficult	difficult	JJ
cord-007444-c9vu8ako	121	7	to	to	TO
cord-007444-c9vu8ako	121	8	distinguish	distinguish	VB
cord-007444-c9vu8ako	121	9	clinically	clinically	RB
cord-007444-c9vu8ako	121	10	between	between	IN
cord-007444-c9vu8ako	121	11	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	121	12	with	with	IN
cord-007444-c9vu8ako	121	13	and	and	CC
cord-007444-c9vu8ako	121	14	without	without	IN
cord-007444-c9vu8ako	121	15	an	an	DT
cord-007444-c9vu8ako	121	16	infectious	infectious	JJ
cord-007444-c9vu8ako	121	17	cause	cause	NN
cord-007444-c9vu8ako	121	18	.	.	.
cord-007444-c9vu8ako	122	1	This	this	DT
cord-007444-c9vu8ako	122	2	distinction	distinction	NN
cord-007444-c9vu8ako	122	3	is	be	VBZ
cord-007444-c9vu8ako	122	4	discussed	discuss	VBN
cord-007444-c9vu8ako	122	5	subsequently	subsequently	RB
cord-007444-c9vu8ako	122	6	in	in	IN
cord-007444-c9vu8ako	122	7	the	the	DT
cord-007444-c9vu8ako	122	8	section	section	NN
cord-007444-c9vu8ako	122	9	on	on	IN
cord-007444-c9vu8ako	122	10	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	122	11	therapy	therapy	NN
cord-007444-c9vu8ako	122	12	.	.	.
cord-007444-c9vu8ako	123	1	Smoking	smoking	NN
cord-007444-c9vu8ako	123	2	cessation	cessation	NN
cord-007444-c9vu8ako	123	3	is	be	VBZ
cord-007444-c9vu8ako	123	4	the	the	DT
cord-007444-c9vu8ako	123	5	most	most	RBS
cord-007444-c9vu8ako	123	6	important	important	JJ
cord-007444-c9vu8ako	123	7	intervention	intervention	NN
cord-007444-c9vu8ako	123	8	in	in	IN
cord-007444-c9vu8ako	123	9	the	the	DT
cord-007444-c9vu8ako	123	10	management	management	NN
cord-007444-c9vu8ako	123	11	of	of	IN
cord-007444-c9vu8ako	123	12	patients	patient	NNS
cord-007444-c9vu8ako	123	13	with	with	IN
cord-007444-c9vu8ako	123	14	COPD	COPD	NNP
cord-007444-c9vu8ako	123	15	.	.	.
cord-007444-c9vu8ako	124	1	The	the	DT
cord-007444-c9vu8ako	124	2	landmark	landmark	NN
cord-007444-c9vu8ako	124	3	Lung	Lung	NNP
cord-007444-c9vu8ako	124	4	Health	Health	NNP
cord-007444-c9vu8ako	124	5	Study	Study	NNP
cord-007444-c9vu8ako	124	6	confirmed	confirm	VBD
cord-007444-c9vu8ako	124	7	that	that	IN
cord-007444-c9vu8ako	124	8	smoking	smoking	NN
cord-007444-c9vu8ako	124	9	cessation	cessation	NN
cord-007444-c9vu8ako	124	10	greatly	greatly	RB
cord-007444-c9vu8ako	124	11	reduces	reduce	VBZ
cord-007444-c9vu8ako	124	12	the	the	DT
cord-007444-c9vu8ako	124	13	rate	rate	NN
cord-007444-c9vu8ako	124	14	of	of	IN
cord-007444-c9vu8ako	124	15	FEVl	FEVl	NNS
cord-007444-c9vu8ako	124	16	decline	decline	NN
cord-007444-c9vu8ako	124	17	.	.	.
cord-007444-c9vu8ako	124	18	'	'	''
cord-007444-c9vu8ako	125	1	"	"	''
cord-007444-c9vu8ako	126	1	The	the	DT
cord-007444-c9vu8ako	126	2	benefit	benefit	NN
cord-007444-c9vu8ako	126	3	of	of	IN
cord-007444-c9vu8ako	126	4	smoking	smoking	NN
cord-007444-c9vu8ako	126	5	cessation	cessation	NN
cord-007444-c9vu8ako	126	6	is	be	VBZ
cord-007444-c9vu8ako	126	7	seen	see	VBN
cord-007444-c9vu8ako	126	8	even	even	RB
cord-007444-c9vu8ako	126	9	in	in	IN
cord-007444-c9vu8ako	126	10	patients	patient	NNS
cord-007444-c9vu8ako	126	11	over	over	IN
cord-007444-c9vu8ako	126	12	the	the	DT
cord-007444-c9vu8ako	126	13	age	age	NN
cord-007444-c9vu8ako	126	14	of	of	IN
cord-007444-c9vu8ako	126	15	60	60	CD
cord-007444-c9vu8ako	126	16	years.56	years.56	NNP
cord-007444-c9vu8ako	126	17	Chronic	Chronic	NNP
cord-007444-c9vu8ako	126	18	sputum	sputum	NN
cord-007444-c9vu8ako	126	19	production	production	NN
cord-007444-c9vu8ako	126	20	often	often	RB
cord-007444-c9vu8ako	126	21	clears	clear	VBZ
cord-007444-c9vu8ako	126	22	within	within	IN
cord-007444-c9vu8ako	126	23	4	4	CD
cord-007444-c9vu8ako	126	24	weeks	week	NNS
cord-007444-c9vu8ako	126	25	of	of	IN
cord-007444-c9vu8ako	126	26	stopping	stop	VBG
cord-007444-c9vu8ako	126	27	Although	although	IN
cord-007444-c9vu8ako	126	28	nicotine	nicotine	NN
cord-007444-c9vu8ako	126	29	replacement	replacement	NN
cord-007444-c9vu8ako	126	30	therapy	therapy	NN
cord-007444-c9vu8ako	126	31	is	be	VBZ
cord-007444-c9vu8ako	126	32	an	an	DT
cord-007444-c9vu8ako	126	33	effective	effective	JJ
cord-007444-c9vu8ako	126	34	approach	approach	NN
cord-007444-c9vu8ako	126	35	to	to	IN
cord-007444-c9vu8ako	126	36	smoking	smoking	NN
cord-007444-c9vu8ako	126	37	cessation	cessation	NN
cord-007444-c9vu8ako	126	38	,	,	,
cord-007444-c9vu8ako	126	39	counseling	counseling	NN
cord-007444-c9vu8ako	126	40	by	by	IN
cord-007444-c9vu8ako	126	41	a	a	DT
cord-007444-c9vu8ako	126	42	physician	physician	NN
cord-007444-c9vu8ako	126	43	has	have	VBZ
cord-007444-c9vu8ako	126	44	been	be	VBN
cord-007444-c9vu8ako	126	45	shown	show	VBN
cord-007444-c9vu8ako	126	46	to	to	TO
cord-007444-c9vu8ako	126	47	be	be	VB
cord-007444-c9vu8ako	126	48	the	the	DT
cord-007444-c9vu8ako	126	49	most	most	RBS
cord-007444-c9vu8ako	126	50	potent	potent	JJ
cord-007444-c9vu8ako	126	51	inter	inter	JJ
cord-007444-c9vu8ako	126	52	-	-	JJ
cord-007444-c9vu8ako	126	53	ver	ver	JJ
cord-007444-c9vu8ako	126	54	~	~	NFP
cord-007444-c9vu8ako	126	55	tion	tion	NN
cord-007444-c9vu8ako	126	56	.	.	.
cord-007444-c9vu8ako	127	1	'	'	``
cord-007444-c9vu8ako	127	2	~~	~~	DT
cord-007444-c9vu8ako	128	1	Each	each	DT
cord-007444-c9vu8ako	128	2	year	year	NN
cord-007444-c9vu8ako	128	3	,	,	,
cord-007444-c9vu8ako	128	4	influenza	influenza	NN
cord-007444-c9vu8ako	128	5	and	and	CC
cord-007444-c9vu8ako	128	6	its	-PRON-	PRP$
cord-007444-c9vu8ako	128	7	complications	complication	NNS
cord-007444-c9vu8ako	128	8	are	be	VBP
cord-007444-c9vu8ako	128	9	responsible	responsible	JJ
cord-007444-c9vu8ako	128	10	for	for	IN
cord-007444-c9vu8ako	128	11	hundreds	hundred	NNS
cord-007444-c9vu8ako	128	12	of	of	IN
cord-007444-c9vu8ako	128	13	thousands	thousand	NNS
cord-007444-c9vu8ako	128	14	of	of	IN
cord-007444-c9vu8ako	128	15	excess	excess	JJ
cord-007444-c9vu8ako	128	16	hospitalizations	hospitalization	NNS
cord-007444-c9vu8ako	128	17	,	,	,
cord-007444-c9vu8ako	128	18	tens	ten	NNS
cord-007444-c9vu8ako	128	19	of	of	IN
cord-007444-c9vu8ako	128	20	thousands	thousand	NNS
cord-007444-c9vu8ako	128	21	of	of	IN
cord-007444-c9vu8ako	128	22	excess	excess	JJ
cord-007444-c9vu8ako	128	23	deaths	death	NNS
cord-007444-c9vu8ako	128	24	,	,	,
cord-007444-c9vu8ako	128	25	and	and	CC
cord-007444-c9vu8ako	128	26	billions	billion	NNS
cord-007444-c9vu8ako	128	27	of	of	IN
cord-007444-c9vu8ako	128	28	dollars	dollar	NNS
cord-007444-c9vu8ako	128	29	in	in	IN
cord-007444-c9vu8ako	128	30	health	health	NN
cord-007444-c9vu8ako	128	31	care	care	NN
cord-007444-c9vu8ako	128	32	C	c	NN
cord-007444-c9vu8ako	128	33	O	o	NN
cord-007444-c9vu8ako	128	34	S	s	NN
cord-007444-c9vu8ako	128	35	~	~	NFP
cord-007444-c9vu8ako	128	36	S	s	NN
cord-007444-c9vu8ako	128	37	.~~,~~	.~~,~~	.
cord-007444-c9vu8ako	129	1	Those	those	DT
cord-007444-c9vu8ako	129	2	with	with	IN
cord-007444-c9vu8ako	129	3	chronic	chronic	JJ
cord-007444-c9vu8ako	129	4	lung	lung	NN
cord-007444-c9vu8ako	129	5	disease	disease	NN
cord-007444-c9vu8ako	129	6	are	be	VBP
cord-007444-c9vu8ako	129	7	at	at	IN
cord-007444-c9vu8ako	129	8	especially	especially	RB
cord-007444-c9vu8ako	129	9	high	high	JJ
cord-007444-c9vu8ako	129	10	risk	risk	NN
cord-007444-c9vu8ako	129	11	for	for	IN
cord-007444-c9vu8ako	129	12	the	the	DT
cord-007444-c9vu8ako	129	13	consequences	consequence	NNS
cord-007444-c9vu8ako	129	14	of	of	IN
cord-007444-c9vu8ako	129	15	influenza	influenza	NN
cord-007444-c9vu8ako	129	16	.	.	.
cord-007444-c9vu8ako	130	1	Despite	despite	IN
cord-007444-c9vu8ako	130	2	recommendations	recommendation	NNS
cord-007444-c9vu8ako	130	3	for	for	IN
cord-007444-c9vu8ako	130	4	annual	annual	JJ
cord-007444-c9vu8ako	130	5	influenza	influenza	NN
cord-007444-c9vu8ako	130	6	vaccination	vaccination	NN
cord-007444-c9vu8ako	130	7	,	,	,
cord-007444-c9vu8ako	130	8	recent	recent	JJ
cord-007444-c9vu8ako	130	9	studies	study	NNS
cord-007444-c9vu8ako	130	10	have	have	VBP
cord-007444-c9vu8ako	130	11	documented	document	VBN
cord-007444-c9vu8ako	130	12	inadequate	inadequate	JJ
cord-007444-c9vu8ako	130	13	vaccination	vaccination	NN
cord-007444-c9vu8ako	130	14	rates	rate	NNS
cord-007444-c9vu8ako	130	15	in	in	IN
cord-007444-c9vu8ako	130	16	this	this	DT
cord-007444-c9vu8ako	130	17	risk	risk	NN
cord-007444-c9vu8ako	130	18	group.91	group.91	NNP
cord-007444-c9vu8ako	130	19	,	,	,
cord-007444-c9vu8ako	130	20	92	92	CD
cord-007444-c9vu8ako	131	1	Among	among	IN
cord-007444-c9vu8ako	131	2	elderly	elderly	JJ
cord-007444-c9vu8ako	131	3	persons	person	NNS
cord-007444-c9vu8ako	131	4	,	,	,
cord-007444-c9vu8ako	131	5	including	include	VBG
cord-007444-c9vu8ako	131	6	those	those	DT
cord-007444-c9vu8ako	131	7	with	with	IN
cord-007444-c9vu8ako	131	8	chronic	chronic	JJ
cord-007444-c9vu8ako	131	9	lung	lung	NN
cord-007444-c9vu8ako	131	10	disease	disease	NN
cord-007444-c9vu8ako	131	11	,	,	,
cord-007444-c9vu8ako	131	12	Nichol	Nichol	NNP
cord-007444-c9vu8ako	131	13	et	et	NNP
cord-007444-c9vu8ako	131	14	alB6	alB6	VBZ
cord-007444-c9vu8ako	131	15	overwhelmingly	overwhelmingly	RB
cord-007444-c9vu8ako	131	16	demonstrated	demonstrate	VBD
cord-007444-c9vu8ako	131	17	the	the	DT
cord-007444-c9vu8ako	131	18	efficacy	efficacy	NN
cord-007444-c9vu8ako	131	19	and	and	CC
cord-007444-c9vu8ako	131	20	cost	cost	NN
cord-007444-c9vu8ako	131	21	effectiveness	effectiveness	NN
cord-007444-c9vu8ako	131	22	of	of	IN
cord-007444-c9vu8ako	131	23	influenza	influenza	NN
cord-007444-c9vu8ako	131	24	vaccination	vaccination	NN
cord-007444-c9vu8ako	131	25	.	.	.
cord-007444-c9vu8ako	132	1	In	in	IN
cord-007444-c9vu8ako	132	2	a	a	DT
cord-007444-c9vu8ako	132	3	serial	serial	JJ
cord-007444-c9vu8ako	132	4	cohort	cohort	NN
cord-007444-c9vu8ako	132	5	study	study	NN
cord-007444-c9vu8ako	132	6	of	of	IN
cord-007444-c9vu8ako	132	7	more	more	JJR
cord-007444-c9vu8ako	132	8	than	than	IN
cord-007444-c9vu8ako	132	9	25,000	25,000	CD
cord-007444-c9vu8ako	132	10	patients,*6	patients,*6	NNP
cord-007444-c9vu8ako	133	1	vaccination	vaccination	NN
cord-007444-c9vu8ako	133	2	was	be	VBD
cord-007444-c9vu8ako	133	3	associated	associate	VBN
cord-007444-c9vu8ako	133	4	with	with	IN
cord-007444-c9vu8ako	133	5	a	a	DT
cord-007444-c9vu8ako	133	6	30	30	CD
cord-007444-c9vu8ako	133	7	%	%	NN
cord-007444-c9vu8ako	133	8	to	to	TO
cord-007444-c9vu8ako	133	9	40	40	CD
cord-007444-c9vu8ako	133	10	%	%	NN
cord-007444-c9vu8ako	133	11	reduction	reduction	NN
cord-007444-c9vu8ako	133	12	in	in	IN
cord-007444-c9vu8ako	133	13	the	the	DT
cord-007444-c9vu8ako	133	14	rate	rate	NN
cord-007444-c9vu8ako	133	15	of	of	IN
cord-007444-c9vu8ako	133	16	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	133	17	for	for	IN
cord-007444-c9vu8ako	133	18	all	all	DT
cord-007444-c9vu8ako	133	19	acute	acute	JJ
cord-007444-c9vu8ako	133	20	and	and	CC
cord-007444-c9vu8ako	133	21	chronic	chronic	JJ
cord-007444-c9vu8ako	133	22	respiratory	respiratory	JJ
cord-007444-c9vu8ako	133	23	conditions	condition	NNS
cord-007444-c9vu8ako	133	24	.	.	.
cord-007444-c9vu8ako	134	1	Another	another	DT
cord-007444-c9vu8ako	134	2	study	study	NN
cord-007444-c9vu8ako	134	3	by	by	IN
cord-007444-c9vu8ako	134	4	the	the	DT
cord-007444-c9vu8ako	134	5	same	same	JJ
cord-007444-c9vu8ako	134	6	authorsa	authorsa	NN
cord-007444-c9vu8ako	134	7	found	find	VBD
cord-007444-c9vu8ako	134	8	that	that	IN
cord-007444-c9vu8ako	134	9	influenza	influenza	NN
cord-007444-c9vu8ako	134	10	vaccination	vaccination	NN
cord-007444-c9vu8ako	134	11	was	be	VBD
cord-007444-c9vu8ako	134	12	associated	associate	VBN
cord-007444-c9vu8ako	134	13	with	with	IN
cord-007444-c9vu8ako	134	14	a	a	DT
cord-007444-c9vu8ako	134	15	70	70	CD
cord-007444-c9vu8ako	134	16	%	%	NN
cord-007444-c9vu8ako	134	17	reduction	reduction	NN
cord-007444-c9vu8ako	134	18	in	in	IN
cord-007444-c9vu8ako	134	19	the	the	DT
cord-007444-c9vu8ako	134	20	risk	risk	NN
cord-007444-c9vu8ako	134	21	for	for	IN
cord-007444-c9vu8ako	134	22	death	death	NN
cord-007444-c9vu8ako	134	23	from	from	IN
cord-007444-c9vu8ako	134	24	any	any	DT
cord-007444-c9vu8ako	134	25	cause	cause	NN
cord-007444-c9vu8ako	134	26	(	(	-LRB-
cord-007444-c9vu8ako	134	27	odds	odd	NNS
cord-007444-c9vu8ako	134	28	ratio	ratio	NN
cord-007444-c9vu8ako	134	29	[	[	-LRB-
cord-007444-c9vu8ako	134	30	OR	or	CC
cord-007444-c9vu8ako	134	31	]	]	-RRB-
cord-007444-c9vu8ako	134	32	=	=	SYM
cord-007444-c9vu8ako	134	33	0.3	0.3	CD
cord-007444-c9vu8ako	134	34	;	;	:
cord-007444-c9vu8ako	134	35	95	95	CD
cord-007444-c9vu8ako	134	36	%	%	NN
cord-007444-c9vu8ako	134	37	confidence	confidence	NN
cord-007444-c9vu8ako	134	38	interval	interval	NN
cord-007444-c9vu8ako	134	39	[	[	-LRB-
cord-007444-c9vu8ako	134	40	CI	CI	NNP
cord-007444-c9vu8ako	134	41	]	]	-RRB-
cord-007444-c9vu8ako	134	42	=	=	SYM
cord-007444-c9vu8ako	134	43	0.21	0.21	CD
cord-007444-c9vu8ako	134	44	-	-	HYPH
cord-007444-c9vu8ako	134	45	0.43	0.43	CD
cord-007444-c9vu8ako	134	46	)	)	-RRB-
cord-007444-c9vu8ako	134	47	.	.	.
cord-007444-c9vu8ako	135	1	A	a	DT
cord-007444-c9vu8ako	135	2	recent	recent	JJ
cord-007444-c9vu8ako	135	3	metaanalysis	metaanalysis	NN
cord-007444-c9vu8ako	135	4	of	of	IN
cord-007444-c9vu8ako	135	5	20	20	CD
cord-007444-c9vu8ako	135	6	cohort	cohort	NN
cord-007444-c9vu8ako	135	7	studies	study	NNS
cord-007444-c9vu8ako	135	8	concluded	conclude	VBD
cord-007444-c9vu8ako	135	9	that	that	IN
cord-007444-c9vu8ako	135	10	the	the	DT
cord-007444-c9vu8ako	135	11	estimates	estimate	NNS
cord-007444-c9vu8ako	135	12	of	of	IN
cord-007444-c9vu8ako	135	13	vaccine	vaccine	NN
cord-007444-c9vu8ako	135	14	efficacy	efficacy	NN
cord-007444-c9vu8ako	135	15	for	for	IN
cord-007444-c9vu8ako	135	16	preventing	prevent	VBG
cord-007444-c9vu8ako	135	17	respiratory	respiratory	JJ
cord-007444-c9vu8ako	135	18	illness	illness	NN
cord-007444-c9vu8ako	135	19	,	,	,
cord-007444-c9vu8ako	135	20	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	135	21	,	,	,
cord-007444-c9vu8ako	135	22	and	and	CC
cord-007444-c9vu8ako	135	23	death	death	NN
cord-007444-c9vu8ako	135	24	were	be	VBD
cord-007444-c9vu8ako	135	25	56	56	CD
cord-007444-c9vu8ako	135	26	%	%	NN
cord-007444-c9vu8ako	135	27	,	,	,
cord-007444-c9vu8ako	135	28	50	50	CD
cord-007444-c9vu8ako	135	29	%	%	NN
cord-007444-c9vu8ako	135	30	and	and	CC
cord-007444-c9vu8ako	135	31	68	68	CD
cord-007444-c9vu8ako	135	32	%	%	NN
cord-007444-c9vu8ako	135	33	,	,	,
cord-007444-c9vu8ako	135	34	respe	respe	NNP
cord-007444-c9vu8ako	135	35	~	~	NFP
cord-007444-c9vu8ako	135	36	tively	tively	NNP
cord-007444-c9vu8ako	135	37	.	.	.
cord-007444-c9vu8ako	136	1	'	'	``
cord-007444-c9vu8ako	136	2	~~	~~	DT
cord-007444-c9vu8ako	137	1	These	these	DT
cord-007444-c9vu8ako	137	2	data	datum	NNS
cord-007444-c9vu8ako	137	3	clearly	clearly	RB
cord-007444-c9vu8ako	137	4	affirm	affirm	VBP
cord-007444-c9vu8ako	137	5	that	that	IN
cord-007444-c9vu8ako	137	6	influenza	influenza	NN
cord-007444-c9vu8ako	137	7	vaccination	vaccination	NN
cord-007444-c9vu8ako	137	8	is	be	VBZ
cord-007444-c9vu8ako	137	9	an	an	DT
cord-007444-c9vu8ako	137	10	indispensable	indispensable	JJ
cord-007444-c9vu8ako	137	11	part	part	NN
cord-007444-c9vu8ako	137	12	of	of	IN
cord-007444-c9vu8ako	137	13	the	the	DT
cord-007444-c9vu8ako	137	14	care	care	NN
cord-007444-c9vu8ako	137	15	of	of	IN
cord-007444-c9vu8ako	137	16	all	all	DT
cord-007444-c9vu8ako	137	17	elderly	elderly	JJ
cord-007444-c9vu8ako	137	18	persons	person	NNS
cord-007444-c9vu8ako	137	19	,	,	,
cord-007444-c9vu8ako	137	20	especially	especially	RB
cord-007444-c9vu8ako	137	21	those	those	DT
cord-007444-c9vu8ako	137	22	with	with	IN
cord-007444-c9vu8ako	137	23	COPD	COPD	NNP
cord-007444-c9vu8ako	137	24	.	.	.
cord-007444-c9vu8ako	138	1	The	the	DT
cord-007444-c9vu8ako	138	2	value	value	NN
cord-007444-c9vu8ako	138	3	of	of	IN
cord-007444-c9vu8ako	138	4	pneumococcal	pneumococcal	JJ
cord-007444-c9vu8ako	138	5	vaccination	vaccination	NN
cord-007444-c9vu8ako	138	6	for	for	IN
cord-007444-c9vu8ako	138	7	elderly	elderly	JJ
cord-007444-c9vu8ako	138	8	patients	patient	NNS
cord-007444-c9vu8ako	138	9	with	with	IN
cord-007444-c9vu8ako	138	10	COPD	COPD	NNP
cord-007444-c9vu8ako	138	11	has	have	VBZ
cord-007444-c9vu8ako	138	12	been	be	VBN
cord-007444-c9vu8ako	138	13	controversial	controversial	JJ
cord-007444-c9vu8ako	138	14	.	.	.
cord-007444-c9vu8ako	139	1	Two	two	CD
cord-007444-c9vu8ako	139	2	randomized	randomized	JJ
cord-007444-c9vu8ako	139	3	controlled	control	VBN
cord-007444-c9vu8ako	139	4	trials	trial	NNS
cord-007444-c9vu8ako	139	5	evaluating	evaluate	VBG
cord-007444-c9vu8ako	139	6	the	the	DT
cord-007444-c9vu8ako	139	7	vaccine	vaccine	NN
cord-007444-c9vu8ako	139	8	's	's	POS
cord-007444-c9vu8ako	139	9	efficacy	efficacy	NN
cord-007444-c9vu8ako	139	10	among	among	IN
cord-007444-c9vu8ako	139	11	patients	patient	NNS
cord-007444-c9vu8ako	139	12	with	with	IN
cord-007444-c9vu8ako	139	13	COPD	COPD	NNP
cord-007444-c9vu8ako	139	14	were	be	VBD
cord-007444-c9vu8ako	139	15	unable	unable	JJ
cord-007444-c9vu8ako	139	16	to	to	TO
cord-007444-c9vu8ako	139	17	show	show	VB
cord-007444-c9vu8ako	139	18	statistically	statistically	RB
cord-007444-c9vu8ako	139	19	significant	significant	JJ
cord-007444-c9vu8ako	139	20	protective	protective	JJ
cord-007444-c9vu8ako	139	21	benefit.36	benefit.36	NN
cord-007444-c9vu8ako	139	22	,	,	,
cord-007444-c9vu8ako	139	23	69	69	CD
cord-007444-c9vu8ako	140	1	A	a	DT
cord-007444-c9vu8ako	140	2	recent	recent	JJ
cord-007444-c9vu8ako	140	3	meta	meta	JJ
cord-007444-c9vu8ako	140	4	-	-	HYPH
cord-007444-c9vu8ako	140	5	analysis	analysis	NN
cord-007444-c9vu8ako	140	6	concluded	conclude	VBD
cord-007444-c9vu8ako	140	7	that	that	IN
cord-007444-c9vu8ako	140	8	the	the	DT
cord-007444-c9vu8ako	140	9	vaccine	vaccine	NN
cord-007444-c9vu8ako	140	10	provides	provide	VBZ
cord-007444-c9vu8ako	140	11	partial	partial	JJ
cord-007444-c9vu8ako	140	12	protection	protection	NN
cord-007444-c9vu8ako	140	13	against	against	IN
cord-007444-c9vu8ako	140	14	bacteremic	bacteremic	JJ
cord-007444-c9vu8ako	140	15	pneumococcal	pneumococcal	JJ
cord-007444-c9vu8ako	140	16	pneumonia	pneumonia	NN
cord-007444-c9vu8ako	140	17	but	but	CC
cord-007444-c9vu8ako	140	18	not	not	RB
cord-007444-c9vu8ako	140	19	against	against	IN
cord-007444-c9vu8ako	140	20	other	other	JJ
cord-007444-c9vu8ako	140	21	important	important	JJ
cord-007444-c9vu8ako	140	22	outcomes	outcome	NNS
cord-007444-c9vu8ako	140	23	,	,	,
cord-007444-c9vu8ako	140	24	including	include	VBG
cord-007444-c9vu8ako	140	25	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	140	26	or	or	CC
cord-007444-c9vu8ako	140	27	mortality	mortality	NN
cord-007444-c9vu8ako	140	28	caused	cause	VBN
cord-007444-c9vu8ako	140	29	by	by	IN
cord-007444-c9vu8ako	140	30	pneumococcal	pneumococcal	JJ
cord-007444-c9vu8ako	140	31	infection	infection	NN
cord-007444-c9vu8ako	140	32	.	.	.
cord-007444-c9vu8ako	141	1	This	this	DT
cord-007444-c9vu8ako	141	2	protective	protective	JJ
cord-007444-c9vu8ako	141	3	benefit	benefit	NN
cord-007444-c9vu8ako	141	4	was	be	VBD
cord-007444-c9vu8ako	141	5	seen	see	VBN
cord-007444-c9vu8ako	141	6	only	only	RB
cord-007444-c9vu8ako	141	7	in	in	IN
cord-007444-c9vu8ako	141	8	low	low	JJ
cord-007444-c9vu8ako	141	9	-	-	HYPH
cord-007444-c9vu8ako	141	10	risk	risk	NN
cord-007444-c9vu8ako	141	11	groups	group	NNS
cord-007444-c9vu8ako	141	12	and	and	CC
cord-007444-c9vu8ako	141	13	not	not	RB
cord-007444-c9vu8ako	141	14	among	among	IN
cord-007444-c9vu8ako	141	15	those	those	DT
cord-007444-c9vu8ako	141	16	with	with	IN
cord-007444-c9vu8ako	141	17	COPD	COPD	NNP
cord-007444-c9vu8ako	141	18	or	or	CC
cord-007444-c9vu8ako	141	19	other	other	JJ
cord-007444-c9vu8ako	141	20	highrisk	highrisk	NNP
cord-007444-c9vu8ako	141	21	patients.46	patients.46	NNP
cord-007444-c9vu8ako	142	1	Nevertheless	nevertheless	RB
cord-007444-c9vu8ako	142	2	,	,	,
cord-007444-c9vu8ako	142	3	pneumococcal	pneumococcal	JJ
cord-007444-c9vu8ako	142	4	vaccination	vaccination	NN
cord-007444-c9vu8ako	142	5	continues	continue	VBZ
cord-007444-c9vu8ako	142	6	to	to	TO
cord-007444-c9vu8ako	142	7	be	be	VB
cord-007444-c9vu8ako	142	8	strongly	strongly	RB
cord-007444-c9vu8ako	142	9	recommended	recommend	VBN
cord-007444-c9vu8ako	142	10	for	for	IN
cord-007444-c9vu8ako	142	11	patients	patient	NNS
cord-007444-c9vu8ako	142	12	with	with	IN
cord-007444-c9vu8ako	142	13	COPD	COPD	NNP
cord-007444-c9vu8ako	142	14	because	because	IN
cord-007444-c9vu8ako	142	15	it	-PRON-	PRP
cord-007444-c9vu8ako	142	16	is	be	VBZ
cord-007444-c9vu8ako	142	17	safe	safe	JJ
cord-007444-c9vu8ako	142	18	and	and	CC
cord-007444-c9vu8ako	142	19	has	have	VBZ
cord-007444-c9vu8ako	142	20	been	be	VBN
cord-007444-c9vu8ako	142	21	found	find	VBN
cord-007444-c9vu8ako	142	22	to	to	TO
cord-007444-c9vu8ako	142	23	provide	provide	VB
cord-007444-c9vu8ako	142	24	significant	significant	JJ
cord-007444-c9vu8ako	142	25	benefit	benefit	NN
cord-007444-c9vu8ako	142	26	for	for	IN
cord-007444-c9vu8ako	142	27	patients	patient	NNS
cord-007444-c9vu8ako	142	28	in	in	IN
cord-007444-c9vu8ako	142	29	case	case	NN
cord-007444-c9vu8ako	142	30	-	-	HYPH
cord-007444-c9vu8ako	142	31	control	control	NN
cord-007444-c9vu8ako	142	32	and	and	CC
cord-007444-c9vu8ako	142	33	indirect	indirect	JJ
cord-007444-c9vu8ako	142	34	cohort	cohort	NN
cord-007444-c9vu8ako	142	35	studiesz6	studiesz6	NN
cord-007444-c9vu8ako	142	36	,	,	,
cord-007444-c9vu8ako	142	37	93	93	CD
cord-007444-c9vu8ako	142	38	,	,	,
cord-007444-c9vu8ako	142	39	ln8	ln8	NNP
cord-007444-c9vu8ako	142	40	as	as	RB
cord-007444-c9vu8ako	142	41	well	well	RB
cord-007444-c9vu8ako	142	42	as	as	IN
cord-007444-c9vu8ako	142	43	in	in	IN
cord-007444-c9vu8ako	142	44	a	a	DT
cord-007444-c9vu8ako	142	45	more	more	RBR
cord-007444-c9vu8ako	142	46	recent	recent	JJ
cord-007444-c9vu8ako	142	47	randomized	randomized	JJ
cord-007444-c9vu8ako	142	48	populationbased	populationbased	JJ
cord-007444-c9vu8ako	142	49	Several	several	JJ
cord-007444-c9vu8ako	142	50	additional	additional	JJ
cord-007444-c9vu8ako	142	51	novel	novel	JJ
cord-007444-c9vu8ako	142	52	strategies	strategy	NNS
cord-007444-c9vu8ako	142	53	for	for	IN
cord-007444-c9vu8ako	142	54	reducing	reduce	VBG
cord-007444-c9vu8ako	142	55	acute	acute	JJ
cord-007444-c9vu8ako	142	56	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	142	57	of	of	IN
cord-007444-c9vu8ako	142	58	COPD	COPD	NNP
cord-007444-c9vu8ako	142	59	are	be	VBP
cord-007444-c9vu8ako	142	60	under	under	IN
cord-007444-c9vu8ako	142	61	investigation	investigation	NN
cord-007444-c9vu8ako	142	62	.	.	.
cord-007444-c9vu8ako	143	1	For	for	IN
cord-007444-c9vu8ako	143	2	example	example	NN
cord-007444-c9vu8ako	143	3	,	,	,
cord-007444-c9vu8ako	143	4	OM-85	OM-85	NNP
cord-007444-c9vu8ako	143	5	BV	BV	NNP
cord-007444-c9vu8ako	143	6	is	be	VBZ
cord-007444-c9vu8ako	143	7	an	an	DT
cord-007444-c9vu8ako	143	8	oral	oral	JJ
cord-007444-c9vu8ako	143	9	immunostimulating	immunostimulate	VBG
cord-007444-c9vu8ako	143	10	agent	agent	NN
cord-007444-c9vu8ako	143	11	containing	contain	VBG
cord-007444-c9vu8ako	143	12	lyophylized	lyophylize	VBN
cord-007444-c9vu8ako	143	13	fractions	fraction	NNS
cord-007444-c9vu8ako	143	14	of	of	IN
cord-007444-c9vu8ako	143	15	the	the	DT
cord-007444-c9vu8ako	143	16	eight	eight	CD
cord-007444-c9vu8ako	143	17	most	most	RBS
cord-007444-c9vu8ako	143	18	common	common	JJ
cord-007444-c9vu8ako	143	19	respiratory	respiratory	JJ
cord-007444-c9vu8ako	143	20	pathogens	pathogen	NNS
cord-007444-c9vu8ako	143	21	.	.	.
cord-007444-c9vu8ako	144	1	Its	-PRON-	PRP$
cord-007444-c9vu8ako	144	2	use	use	NN
cord-007444-c9vu8ako	144	3	was	be	VBD
cord-007444-c9vu8ako	144	4	associated	associate	VBN
cord-007444-c9vu8ako	144	5	with	with	IN
cord-007444-c9vu8ako	144	6	a	a	DT
cord-007444-c9vu8ako	144	7	40	40	CD
cord-007444-c9vu8ako	144	8	%	%	NN
cord-007444-c9vu8ako	144	9	reduction	reduction	NN
cord-007444-c9vu8ako	144	10	in	in	IN
cord-007444-c9vu8ako	144	11	the	the	DT
cord-007444-c9vu8ako	144	12	incidence	incidence	NN
cord-007444-c9vu8ako	144	13	of	of	IN
cord-007444-c9vu8ako	144	14	acute	acute	JJ
cord-007444-c9vu8ako	144	15	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	144	16	of	of	IN
cord-007444-c9vu8ako	144	17	chronic	chronic	JJ
cord-007444-c9vu8ako	144	18	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	144	19	and	and	CC
cord-007444-c9vu8ako	144	20	a	a	DT
cord-007444-c9vu8ako	144	21	28	28	CD
cord-007444-c9vu8ako	144	22	%	%	NN
cord-007444-c9vu8ako	144	23	decrease	decrease	NN
cord-007444-c9vu8ako	144	24	in	in	IN
cord-007444-c9vu8ako	144	25	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	144	26	use	use	NN
cord-007444-c9vu8ako	144	27	among	among	IN
cord-007444-c9vu8ako	144	28	elderly	elderly	JJ
cord-007444-c9vu8ako	144	29	institutionalized	institutionalized	JJ
cord-007444-c9vu8ako	144	30	patients	patient	NNS
cord-007444-c9vu8ako	144	31	in	in	IN
cord-007444-c9vu8ako	144	32	one	one	CD
cord-007444-c9vu8ako	144	33	trial	trial	NN
cord-007444-c9vu8ako	144	34	,	,	,
cord-007444-c9vu8ako	144	35	and	and	CC
cord-007444-c9vu8ako	144	36	the	the	DT
cord-007444-c9vu8ako	144	37	same	same	JJ
cord-007444-c9vu8ako	144	38	frequency	frequency	NN
cord-007444-c9vu8ako	144	39	of	of	IN
cord-007444-c9vu8ako	144	40	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	144	41	but	but	CC
cord-007444-c9vu8ako	144	42	less	less	JJR
cord-007444-c9vu8ako	144	43	than	than	IN
cord-007444-c9vu8ako	144	44	half	half	PDT
cord-007444-c9vu8ako	144	45	as	as	RB
cord-007444-c9vu8ako	144	46	many	many	JJ
cord-007444-c9vu8ako	144	47	days	day	NNS
cord-007444-c9vu8ako	144	48	in	in	IN
cord-007444-c9vu8ako	144	49	hospital	hospital	NN
cord-007444-c9vu8ako	144	50	as	as	IN
cord-007444-c9vu8ako	144	51	those	those	DT
cord-007444-c9vu8ako	144	52	given	give	VBN
cord-007444-c9vu8ako	144	53	placebo	placebo	NN
cord-007444-c9vu8ako	144	54	in	in	IN
cord-007444-c9vu8ako	144	55	another	another	DT
cord-007444-c9vu8ako	144	56	?	?	.
cord-007444-c9vu8ako	145	1	,	,	,
cord-007444-c9vu8ako	145	2	,	,	,
cord-007444-c9vu8ako	145	3	9n	9n	LS
cord-007444-c9vu8ako	145	4	There	there	EX
cord-007444-c9vu8ako	145	5	was	be	VBD
cord-007444-c9vu8ako	145	6	a	a	DT
cord-007444-c9vu8ako	145	7	trend	trend	NN
cord-007444-c9vu8ako	145	8	toward	toward	IN
cord-007444-c9vu8ako	145	9	fewer	few	JJR
cord-007444-c9vu8ako	145	10	hospitalizations	hospitalization	NNS
cord-007444-c9vu8ako	145	11	for	for	IN
cord-007444-c9vu8ako	145	12	respiratory	respiratory	JJ
cord-007444-c9vu8ako	145	13	reasons	reason	NNS
cord-007444-c9vu8ako	145	14	among	among	IN
cord-007444-c9vu8ako	145	15	those	those	DT
cord-007444-c9vu8ako	145	16	receiving	receive	VBG
cord-007444-c9vu8ako	145	17	the	the	DT
cord-007444-c9vu8ako	145	18	immunostimulating	immunostimulate	VBG
cord-007444-c9vu8ako	145	19	drug	drug	NN
cord-007444-c9vu8ako	145	20	.	.	.
cord-007444-c9vu8ako	146	1	Although	although	IN
cord-007444-c9vu8ako	146	2	not	not	RB
cord-007444-c9vu8ako	146	3	available	available	JJ
cord-007444-c9vu8ako	146	4	in	in	IN
cord-007444-c9vu8ako	146	5	North	North	NNP
cord-007444-c9vu8ako	146	6	America	America	NNP
cord-007444-c9vu8ako	146	7	,	,	,
cord-007444-c9vu8ako	146	8	OM-85	OM-85	NNP
cord-007444-c9vu8ako	146	9	BV	BV	NNP
cord-007444-c9vu8ako	146	10	has	have	VBZ
cord-007444-c9vu8ako	146	11	been	be	VBN
cord-007444-c9vu8ako	146	12	used	use	VBN
cord-007444-c9vu8ako	146	13	for	for	IN
cord-007444-c9vu8ako	146	14	many	many	JJ
cord-007444-c9vu8ako	146	15	years	year	NNS
cord-007444-c9vu8ako	146	16	in	in	IN
cord-007444-c9vu8ako	146	17	Europe	Europe	NNP
cord-007444-c9vu8ako	146	18	.	.	.
cord-007444-c9vu8ako	147	1	Further	further	JJ
cord-007444-c9vu8ako	147	2	trials	trial	NNS
cord-007444-c9vu8ako	147	3	are	be	VBP
cord-007444-c9vu8ako	147	4	required	require	VBN
cord-007444-c9vu8ako	147	5	to	to	TO
cord-007444-c9vu8ako	147	6	properly	properly	RB
cord-007444-c9vu8ako	147	7	define	define	VB
cord-007444-c9vu8ako	147	8	its	-PRON-	PRP$
cord-007444-c9vu8ako	147	9	role	role	NN
cord-007444-c9vu8ako	147	10	.	.	.
cord-007444-c9vu8ako	148	1	Another	another	DT
cord-007444-c9vu8ako	148	2	approach	approach	NN
cord-007444-c9vu8ako	148	3	has	have	VBZ
cord-007444-c9vu8ako	148	4	been	be	VBN
cord-007444-c9vu8ako	148	5	the	the	DT
cord-007444-c9vu8ako	148	6	subcutaneous	subcutaneous	JJ
cord-007444-c9vu8ako	148	7	administration	administration	NN
cord-007444-c9vu8ako	148	8	of	of	IN
cord-007444-c9vu8ako	148	9	hyaluronic	hyaluronic	NN
cord-007444-c9vu8ako	148	10	acid	acid	NN
cord-007444-c9vu8ako	148	11	(	(	-LRB-
cord-007444-c9vu8ako	148	12	HA	HA	NNP
cord-007444-c9vu8ako	148	13	)	)	-RRB-
cord-007444-c9vu8ako	148	14	,	,	,
cord-007444-c9vu8ako	148	15	a	a	DT
cord-007444-c9vu8ako	148	16	glycosaminoglycan	glycosaminoglycan	NN
cord-007444-c9vu8ako	148	17	with	with	IN
cord-007444-c9vu8ako	148	18	neutrophil	neutrophil	NN
cord-007444-c9vu8ako	148	19	-	-	HYPH
cord-007444-c9vu8ako	148	20	regulating	regulating	NN
cord-007444-c9vu8ako	148	21	functions	function	NNS
cord-007444-c9vu8ako	148	22	,	,	,
cord-007444-c9vu8ako	148	23	to	to	IN
cord-007444-c9vu8ako	148	24	patients	patient	NNS
cord-007444-c9vu8ako	148	25	with	with	IN
cord-007444-c9vu8ako	148	26	chronic	chronic	JJ
cord-007444-c9vu8ako	148	27	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	148	28	.	.	.
cord-007444-c9vu8ako	149	1	Fewer	few	JJR
cord-007444-c9vu8ako	149	2	acute	acute	JJ
cord-007444-c9vu8ako	149	3	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	149	4	of	of	IN
cord-007444-c9vu8ako	149	5	bronchtis	bronchtis	NN
cord-007444-c9vu8ako	149	6	and	and	CC
cord-007444-c9vu8ako	149	7	reduced	reduce	VBN
cord-007444-c9vu8ako	149	8	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	149	9	use	use	NN
cord-007444-c9vu8ako	149	10	were	be	VBD
cord-007444-c9vu8ako	149	11	noted	note	VBN
cord-007444-c9vu8ako	149	12	among	among	IN
cord-007444-c9vu8ako	149	13	HA	HA	NNP
cord-007444-c9vu8ako	149	14	-	-	HYPH
cord-007444-c9vu8ako	149	15	treated	treat	VBN
cord-007444-c9vu8ako	149	16	patients	patient	NNS
cord-007444-c9vu8ako	149	17	in	in	IN
cord-007444-c9vu8ako	149	18	a	a	DT
cord-007444-c9vu8ako	149	19	placebo	placebo	NN
cord-007444-c9vu8ako	149	20	-	-	HYPH
cord-007444-c9vu8ako	149	21	controlled	control	VBN
cord-007444-c9vu8ako	149	22	crossover	crossover	NN
cord-007444-c9vu8ako	149	23	study	study	NN
cord-007444-c9vu8ako	149	24	.	.	.
cord-007444-c9vu8ako	150	1	130	130	CD
cord-007444-c9vu8ako	150	2	Other	other	JJ
cord-007444-c9vu8ako	150	3	investigators	investigator	NNS
cord-007444-c9vu8ako	150	4	found	find	VBD
cord-007444-c9vu8ako	150	5	that	that	IN
cord-007444-c9vu8ako	150	6	continous	continous	JJ
cord-007444-c9vu8ako	150	7	administration	administration	NN
cord-007444-c9vu8ako	150	8	of	of	IN
cord-007444-c9vu8ako	150	9	carbocysteine	carbocysteine	NNP
cord-007444-c9vu8ako	150	10	lysine	lysine	NN
cord-007444-c9vu8ako	150	11	salt	salt	NN
cord-007444-c9vu8ako	150	12	monohydrate	monohydrate	NN
cord-007444-c9vu8ako	150	13	during	during	IN
cord-007444-c9vu8ako	150	14	winter	winter	NN
cord-007444-c9vu8ako	150	15	months	month	NNS
cord-007444-c9vu8ako	150	16	was	be	VBD
cord-007444-c9vu8ako	150	17	effective	effective	JJ
cord-007444-c9vu8ako	150	18	in	in	IN
cord-007444-c9vu8ako	150	19	preventing	prevent	VBG
cord-007444-c9vu8ako	150	20	AE	AE	NNP
cord-007444-c9vu8ako	150	21	-	-	HYPH
cord-007444-c9vu8ako	150	22	COPD	COPD	NNP
cord-007444-c9vu8ako	150	23	and	and	CC
cord-007444-c9vu8ako	150	24	reducing	reduce	VBG
cord-007444-c9vu8ako	150	25	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	150	26	consumption	consumption	NN
cord-007444-c9vu8ako	150	27	in	in	IN
cord-007444-c9vu8ako	150	28	patients	patient	NNS
cord-007444-c9vu8ako	150	29	with	with	IN
cord-007444-c9vu8ako	150	30	chronic	chronic	NN
cord-007444-c9vu8ako	150	31	b	b	NN
cord-007444-c9vu8ako	150	32	r	r	NN
cord-007444-c9vu8ako	150	33	~	~	NFP
cord-007444-c9vu8ako	150	34	n	n	NN
cord-007444-c9vu8ako	150	35	c	c	NN
cord-007444-c9vu8ako	150	36	h	h	NN
cord-007444-c9vu8ako	150	37	t	t	NN
cord-007444-c9vu8ako	151	1	i	i	PRP
cord-007444-c9vu8ako	151	2	s	s	NNP
cord-007444-c9vu8ako	151	3	.~	.~	.
cord-007444-c9vu8ako	152	1	Despite	despite	IN
cord-007444-c9vu8ako	152	2	these	these	DT
cord-007444-c9vu8ako	152	3	recent	recent	JJ
cord-007444-c9vu8ako	152	4	intriguing	intriguing	JJ
cord-007444-c9vu8ako	152	5	data	datum	NNS
cord-007444-c9vu8ako	152	6	suggesting	suggest	VBG
cord-007444-c9vu8ako	152	7	that	that	IN
cord-007444-c9vu8ako	152	8	immunomodulatory	immunomodulatory	JJ
cord-007444-c9vu8ako	152	9	agents	agent	NNS
cord-007444-c9vu8ako	152	10	may	may	MD
cord-007444-c9vu8ako	152	11	attenuate	attenuate	VB
cord-007444-c9vu8ako	152	12	the	the	DT
cord-007444-c9vu8ako	152	13	development	development	NN
cord-007444-c9vu8ako	152	14	of	of	IN
cord-007444-c9vu8ako	152	15	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	152	16	,	,	,
cord-007444-c9vu8ako	152	17	randomized	randomized	JJ
cord-007444-c9vu8ako	152	18	,	,	,
cord-007444-c9vu8ako	152	19	controlled	controlled	JJ
cord-007444-c9vu8ako	152	20	trials	trial	NNS
cord-007444-c9vu8ako	152	21	are	be	VBP
cord-007444-c9vu8ako	152	22	needed	need	VBN
cord-007444-c9vu8ako	152	23	to	to	TO
cord-007444-c9vu8ako	152	24	clarify	clarify	VB
cord-007444-c9vu8ako	152	25	their	-PRON-	PRP$
cord-007444-c9vu8ako	152	26	potential	potential	JJ
cord-007444-c9vu8ako	152	27	roles	role	NNS
cord-007444-c9vu8ako	152	28	in	in	IN
cord-007444-c9vu8ako	152	29	the	the	DT
cord-007444-c9vu8ako	152	30	routine	routine	JJ
cord-007444-c9vu8ako	152	31	management	management	NN
cord-007444-c9vu8ako	152	32	of	of	IN
cord-007444-c9vu8ako	152	33	patients	patient	NNS
cord-007444-c9vu8ako	152	34	with	with	IN
cord-007444-c9vu8ako	152	35	COPD	COPD	NNP
cord-007444-c9vu8ako	152	36	.	.	.
cord-007444-c9vu8ako	153	1	The	the	DT
cord-007444-c9vu8ako	153	2	following	following	JJ
cord-007444-c9vu8ako	153	3	sections	section	NNS
cord-007444-c9vu8ako	153	4	provide	provide	VBP
cord-007444-c9vu8ako	153	5	an	an	DT
cord-007444-c9vu8ako	153	6	overview	overview	NN
cord-007444-c9vu8ako	153	7	of	of	IN
cord-007444-c9vu8ako	153	8	the	the	DT
cord-007444-c9vu8ako	153	9	merits	merit	NNS
cord-007444-c9vu8ako	153	10	(	(	-LRB-
cord-007444-c9vu8ako	153	11	or	or	CC
cord-007444-c9vu8ako	153	12	lack	lack	NN
cord-007444-c9vu8ako	153	13	thereof	thereof	RB
cord-007444-c9vu8ako	153	14	)	)	-RRB-
cord-007444-c9vu8ako	153	15	of	of	IN
cord-007444-c9vu8ako	153	16	common	common	JJ
cord-007444-c9vu8ako	153	17	therapeutic	therapeutic	JJ
cord-007444-c9vu8ako	153	18	interventions	intervention	NNS
cord-007444-c9vu8ako	153	19	for	for	IN
cord-007444-c9vu8ako	153	20	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	153	21	.	.	.
cord-007444-c9vu8ako	154	1	Controlled	control	VBN
cord-007444-c9vu8ako	154	2	oxygen	oxygen	NN
cord-007444-c9vu8ako	154	3	(	(	-LRB-
cord-007444-c9vu8ako	154	4	O	o	UH
cord-007444-c9vu8ako	154	5	,	,	,
cord-007444-c9vu8ako	154	6	)	)	-RRB-
cord-007444-c9vu8ako	154	7	,	,	,
cord-007444-c9vu8ako	154	8	bronchodilators	bronchodilator	NNS
cord-007444-c9vu8ako	154	9	,	,	,
cord-007444-c9vu8ako	154	10	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	154	11	,	,	,
cord-007444-c9vu8ako	154	12	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	154	13	,	,	,
cord-007444-c9vu8ako	154	14	noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	154	15	ventilation	ventilation	NN
cord-007444-c9vu8ako	154	16	,	,	,
cord-007444-c9vu8ako	154	17	nutritional	nutritional	JJ
cord-007444-c9vu8ako	154	18	support	support	NN
cord-007444-c9vu8ako	154	19	,	,	,
cord-007444-c9vu8ako	154	20	and	and	CC
cord-007444-c9vu8ako	154	21	chest	chest	NN
cord-007444-c9vu8ako	154	22	physiotherapy	physiotherapy	NN
cord-007444-c9vu8ako	154	23	are	be	VBP
cord-007444-c9vu8ako	154	24	discussed	discuss	VBN
cord-007444-c9vu8ako	154	25	.	.	.
cord-007444-c9vu8ako	155	1	When	when	WRB
cord-007444-c9vu8ako	155	2	available	available	JJ
cord-007444-c9vu8ako	155	3	,	,	,
cord-007444-c9vu8ako	155	4	evidence	evidence	NN
cord-007444-c9vu8ako	155	5	from	from	IN
cord-007444-c9vu8ako	155	6	randomized	randomized	JJ
cord-007444-c9vu8ako	155	7	controlled	control	VBN
cord-007444-c9vu8ako	155	8	trials	trial	NNS
cord-007444-c9vu8ako	155	9	is	be	VBZ
cord-007444-c9vu8ako	155	10	presented	present	VBN
cord-007444-c9vu8ako	155	11	.	.	.
cord-007444-c9vu8ako	156	1	Hypoxemia	Hypoxemia	NNP
cord-007444-c9vu8ako	156	2	is	be	VBZ
cord-007444-c9vu8ako	156	3	the	the	DT
cord-007444-c9vu8ako	156	4	most	most	RBS
cord-007444-c9vu8ako	156	5	immediate	immediate	JJ
cord-007444-c9vu8ako	156	6	threat	threat	NN
cord-007444-c9vu8ako	156	7	to	to	IN
cord-007444-c9vu8ako	156	8	life	life	NN
cord-007444-c9vu8ako	156	9	for	for	IN
cord-007444-c9vu8ako	156	10	patients	patient	NNS
cord-007444-c9vu8ako	156	11	with	with	IN
cord-007444-c9vu8ako	156	12	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	156	13	.	.	.
cord-007444-c9vu8ako	157	1	Hypercapnia	Hypercapnia	NNP
cord-007444-c9vu8ako	157	2	is	be	VBZ
cord-007444-c9vu8ako	157	3	a	a	DT
cord-007444-c9vu8ako	157	4	wellrecognized	wellrecognized	JJ
cord-007444-c9vu8ako	157	5	consequence	consequence	NN
cord-007444-c9vu8ako	157	6	of	of	IN
cord-007444-c9vu8ako	157	7	0	0	CD
cord-007444-c9vu8ako	157	8	,	,	,
cord-007444-c9vu8ako	157	9	therapy	therapy	NN
cord-007444-c9vu8ako	157	10	.	.	.
cord-007444-c9vu8ako	158	1	In	in	IN
cord-007444-c9vu8ako	158	2	the	the	DT
cord-007444-c9vu8ako	158	3	past	past	NN
cord-007444-c9vu8ako	158	4	,	,	,
cord-007444-c9vu8ako	158	5	the	the	DT
cord-007444-c9vu8ako	158	6	risk	risk	NN
cord-007444-c9vu8ako	158	7	of	of	IN
cord-007444-c9vu8ako	158	8	hypoventilation	hypoventilation	NN
cord-007444-c9vu8ako	158	9	or	or	CC
cord-007444-c9vu8ako	158	10	even	even	RB
cord-007444-c9vu8ako	158	11	apnea	apnea	NN
cord-007444-c9vu8ako	158	12	resulting	result	VBG
cord-007444-c9vu8ako	158	13	from	from	IN
cord-007444-c9vu8ako	158	14	0	0	CD
cord-007444-c9vu8ako	158	15	,	,	,
cord-007444-c9vu8ako	158	16	administration	administration	NN
cord-007444-c9vu8ako	158	17	has	have	VBZ
cord-007444-c9vu8ako	158	18	been	be	VBN
cord-007444-c9vu8ako	158	19	vastly	vastly	RB
cord-007444-c9vu8ako	158	20	overestimated	overestimate	VBN
cord-007444-c9vu8ako	158	21	,	,	,
cord-007444-c9vu8ako	158	22	and	and	CC
cord-007444-c9vu8ako	158	23	the	the	DT
cord-007444-c9vu8ako	158	24	notion	notion	NN
cord-007444-c9vu8ako	158	25	that	that	IN
cord-007444-c9vu8ako	158	26	0	0	CD
cord-007444-c9vu8ako	158	27	,	,	,
cord-007444-c9vu8ako	158	28	commonly	commonly	RB
cord-007444-c9vu8ako	158	29	induces	induce	VBZ
cord-007444-c9vu8ako	158	30	clinically	clinically	RB
cord-007444-c9vu8ako	158	31	important	important	JJ
cord-007444-c9vu8ako	158	32	hypercarbia	hypercarbia	NN
cord-007444-c9vu8ako	158	33	and	and	CC
cord-007444-c9vu8ako	158	34	acidosis	acidosis	NN
cord-007444-c9vu8ako	158	35	has	have	VBZ
cord-007444-c9vu8ako	158	36	been	be	VBN
cord-007444-c9vu8ako	158	37	discredited	discredit	VBN
cord-007444-c9vu8ako	158	38	.	.	.
cord-007444-c9vu8ako	158	39	'	'	''
cord-007444-c9vu8ako	159	1	"	"	``
cord-007444-c9vu8ako	159	2	13	13	CD
cord-007444-c9vu8ako	159	3	,	,	,
cord-007444-c9vu8ako	159	4	39	39	CD
cord-007444-c9vu8ako	159	5	,	,	,
cord-007444-c9vu8ako	159	6	lo4	lo4	NNP
cord-007444-c9vu8ako	159	7	The	the	DT
cord-007444-c9vu8ako	159	8	traditional	traditional	JJ
cord-007444-c9vu8ako	159	9	concept	concept	NN
cord-007444-c9vu8ako	159	10	is	be	VBZ
cord-007444-c9vu8ako	159	11	that	that	DT
cord-007444-c9vu8ako	159	12	correction	correction	NN
cord-007444-c9vu8ako	159	13	of	of	IN
cord-007444-c9vu8ako	159	14	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	159	15	with	with	IN
cord-007444-c9vu8ako	159	16	supplemental	supplemental	JJ
cord-007444-c9vu8ako	159	17	Oz	Oz	NNP
cord-007444-c9vu8ako	159	18	removes	remove	VBZ
cord-007444-c9vu8ako	159	19	the	the	DT
cord-007444-c9vu8ako	159	20	hypoxic	hypoxic	JJ
cord-007444-c9vu8ako	159	21	drive	drive	NN
cord-007444-c9vu8ako	159	22	to	to	TO
cord-007444-c9vu8ako	159	23	breathe	breathe	VB
cord-007444-c9vu8ako	159	24	and	and	CC
cord-007444-c9vu8ako	159	25	leads	lead	VBZ
cord-007444-c9vu8ako	159	26	to	to	IN
cord-007444-c9vu8ako	159	27	a	a	DT
cord-007444-c9vu8ako	159	28	fall	fall	NN
cord-007444-c9vu8ako	159	29	in	in	IN
cord-007444-c9vu8ako	159	30	minute	minute	NN
cord-007444-c9vu8ako	159	31	ventilation	ventilation	NN
cord-007444-c9vu8ako	159	32	and	and	CC
cord-007444-c9vu8ako	159	33	subsequent	subsequent	JJ
cord-007444-c9vu8ako	159	34	carbon	carbon	NN
cord-007444-c9vu8ako	159	35	dioxide	dioxide	NN
cord-007444-c9vu8ako	159	36	(	(	-LRB-
cord-007444-c9vu8ako	159	37	CO	CO	NNP
cord-007444-c9vu8ako	159	38	,	,	,
cord-007444-c9vu8ako	159	39	)	)	-RRB-
cord-007444-c9vu8ako	160	1	retention.47	retention.47	NNP
cord-007444-c9vu8ako	160	2	Aubier	Aubier	NNP
cord-007444-c9vu8ako	160	3	et	et	NNP
cord-007444-c9vu8ako	160	4	all2	all2	NN
cord-007444-c9vu8ako	160	5	found	find	VBD
cord-007444-c9vu8ako	160	6	that	that	IN
cord-007444-c9vu8ako	160	7	although	although	IN
cord-007444-c9vu8ako	160	8	administration	administration	NN
cord-007444-c9vu8ako	160	9	of	of	IN
cord-007444-c9vu8ako	160	10	supplemental	supplemental	NNP
cord-007444-c9vu8ako	160	11	Oz	Oz	NNP
cord-007444-c9vu8ako	160	12	does	do	VBZ
cord-007444-c9vu8ako	160	13	reduce	reduce	VB
cord-007444-c9vu8ako	160	14	minute	minute	NN
cord-007444-c9vu8ako	160	15	ventilation	ventilation	NN
cord-007444-c9vu8ako	160	16	and	and	CC
cord-007444-c9vu8ako	160	17	increase	increase	VB
cord-007444-c9vu8ako	160	18	arterial	arterial	JJ
cord-007444-c9vu8ako	160	19	partial	partial	JJ
cord-007444-c9vu8ako	160	20	pressure	pressure	NN
cord-007444-c9vu8ako	160	21	of	of	IN
cord-007444-c9vu8ako	160	22	carbon	carbon	NN
cord-007444-c9vu8ako	160	23	dioxide	dioxide	NN
cord-007444-c9vu8ako	160	24	(	(	-LRB-
cord-007444-c9vu8ako	160	25	Paco	Paco	NNP
cord-007444-c9vu8ako	160	26	,	,	,
cord-007444-c9vu8ako	160	27	)	)	-RRB-
cord-007444-c9vu8ako	160	28	,	,	,
cord-007444-c9vu8ako	160	29	mouth	mouth	NN
cord-007444-c9vu8ako	160	30	occlusion	occlusion	NN
cord-007444-c9vu8ako	160	31	pressure	pressure	NN
cord-007444-c9vu8ako	160	32	(	(	-LRB-
cord-007444-c9vu8ako	160	33	an	an	DT
cord-007444-c9vu8ako	160	34	indicator	indicator	NN
cord-007444-c9vu8ako	160	35	of	of	IN
cord-007444-c9vu8ako	160	36	central	central	JJ
cord-007444-c9vu8ako	160	37	respiratory	respiratory	JJ
cord-007444-c9vu8ako	160	38	drive	drive	NN
cord-007444-c9vu8ako	160	39	)	)	-RRB-
cord-007444-c9vu8ako	160	40	was	be	VBD
cord-007444-c9vu8ako	160	41	significantly	significantly	RB
cord-007444-c9vu8ako	160	42	higher	high	JJR
cord-007444-c9vu8ako	160	43	during	during	IN
cord-007444-c9vu8ako	160	44	acute	acute	JJ
cord-007444-c9vu8ako	160	45	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	160	46	than	than	IN
cord-007444-c9vu8ako	160	47	during	during	IN
cord-007444-c9vu8ako	160	48	stable	stable	JJ
cord-007444-c9vu8ako	160	49	conditions	condition	NNS
cord-007444-c9vu8ako	160	50	.	.	.
cord-007444-c9vu8ako	161	1	The	the	DT
cord-007444-c9vu8ako	161	2	drive	drive	NN
cord-007444-c9vu8ako	161	3	to	to	TO
cord-007444-c9vu8ako	161	4	breathe	breathe	VB
cord-007444-c9vu8ako	161	5	therefore	therefore	RB
cord-007444-c9vu8ako	161	6	remained	remain	VBD
cord-007444-c9vu8ako	161	7	very	very	RB
cord-007444-c9vu8ako	161	8	high	high	JJ
cord-007444-c9vu8ako	161	9	in	in	IN
cord-007444-c9vu8ako	161	10	spite	spite	NN
cord-007444-c9vu8ako	161	11	of	of	IN
cord-007444-c9vu8ako	161	12	oxygen	oxygen	NN
cord-007444-c9vu8ako	161	13	treatment	treatment	NN
cord-007444-c9vu8ako	161	14	.	.	.
cord-007444-c9vu8ako	162	1	In	in	IN
cord-007444-c9vu8ako	162	2	a	a	DT
cord-007444-c9vu8ako	162	3	later	later	JJ
cord-007444-c9vu8ako	162	4	study	study	NN
cord-007444-c9vu8ako	162	5	by	by	IN
cord-007444-c9vu8ako	162	6	the	the	DT
cord-007444-c9vu8ako	162	7	same	same	JJ
cord-007444-c9vu8ako	162	8	authors	author	NNS
cord-007444-c9vu8ako	162	9	,	,	,
cord-007444-c9vu8ako	162	10	I3	I3	NNP
cord-007444-c9vu8ako	162	11	patients	patient	NNS
cord-007444-c9vu8ako	162	12	with	with	IN
cord-007444-c9vu8ako	162	13	COPD	COPD	NNP
cord-007444-c9vu8ako	162	14	and	and	CC
cord-007444-c9vu8ako	162	15	acute	acute	JJ
cord-007444-c9vu8ako	162	16	respiratory	respiratory	JJ
cord-007444-c9vu8ako	162	17	failure	failure	NN
cord-007444-c9vu8ako	162	18	received	receive	VBD
cord-007444-c9vu8ako	162	19	100	100	CD
cord-007444-c9vu8ako	162	20	%	%	NN
cord-007444-c9vu8ako	162	21	0	0	CD
cord-007444-c9vu8ako	162	22	,	,	,
cord-007444-c9vu8ako	162	23	for	for	IN
cord-007444-c9vu8ako	162	24	15	15	CD
cord-007444-c9vu8ako	162	25	minutes	minute	NNS
cord-007444-c9vu8ako	162	26	to	to	TO
cord-007444-c9vu8ako	162	27	abolish	abolish	VB
cord-007444-c9vu8ako	162	28	hypoxic	hypoxic	JJ
cord-007444-c9vu8ako	162	29	drive	drive	NN
cord-007444-c9vu8ako	162	30	.	.	.
cord-007444-c9vu8ako	163	1	Minute	minute	NN
cord-007444-c9vu8ako	163	2	ventilation	ventilation	NN
cord-007444-c9vu8ako	163	3	fell	fall	VBD
cord-007444-c9vu8ako	163	4	by	by	IN
cord-007444-c9vu8ako	163	5	only	only	RB
cord-007444-c9vu8ako	163	6	7	7	CD
cord-007444-c9vu8ako	163	7	%	%	NN
cord-007444-c9vu8ako	163	8	and	and	CC
cord-007444-c9vu8ako	163	9	could	could	MD
cord-007444-c9vu8ako	163	10	not	not	RB
cord-007444-c9vu8ako	163	11	account	account	VB
cord-007444-c9vu8ako	163	12	for	for	IN
cord-007444-c9vu8ako	163	13	the	the	DT
cord-007444-c9vu8ako	163	14	entire	entire	JJ
cord-007444-c9vu8ako	163	15	increase	increase	NN
cord-007444-c9vu8ako	163	16	in	in	IN
cord-007444-c9vu8ako	163	17	Paco	Paco	NNP
cord-007444-c9vu8ako	163	18	,	,	,
cord-007444-c9vu8ako	163	19	.	.	.
cord-007444-c9vu8ako	164	1	The	the	DT
cord-007444-c9vu8ako	164	2	authors	author	NNS
cord-007444-c9vu8ako	164	3	concluded	conclude	VBD
cord-007444-c9vu8ako	164	4	that	that	IN
cord-007444-c9vu8ako	164	5	the	the	DT
cord-007444-c9vu8ako	164	6	rise	rise	NN
cord-007444-c9vu8ako	164	7	in	in	IN
cord-007444-c9vu8ako	164	8	C02	C02	NNP
cord-007444-c9vu8ako	164	9	was	be	VBD
cord-007444-c9vu8ako	164	10	caused	cause	VBN
cord-007444-c9vu8ako	164	11	by	by	IN
cord-007444-c9vu8ako	164	12	increased	increase	VBN
cord-007444-c9vu8ako	164	13	VD	VD	NNP
cord-007444-c9vu8ako	164	14	/	/	SYM
cord-007444-c9vu8ako	164	15	VT	VT	NNP
cord-007444-c9vu8ako	164	16	)	)	-RRB-
cord-007444-c9vu8ako	165	1	(	(	-LRB-
cord-007444-c9vu8ako	165	2	i.e.	i.e.	FW
cord-007444-c9vu8ako	165	3	,	,	,
cord-007444-c9vu8ako	165	4	increased	increase	VBN
cord-007444-c9vu8ako	165	5	deadspace	deadspace	NNP
cord-007444-c9vu8ako	165	6	ventilation	ventilation	NN
cord-007444-c9vu8ako	165	7	)	)	-RRB-
cord-007444-c9vu8ako	165	8	and	and	CC
cord-007444-c9vu8ako	165	9	that	that	IN
cord-007444-c9vu8ako	165	10	the	the	DT
cord-007444-c9vu8ako	165	11	primary	primary	JJ
cord-007444-c9vu8ako	165	12	mechanism	mechanism	NN
cord-007444-c9vu8ako	165	13	of	of	IN
cord-007444-c9vu8ako	165	14	Oz	Oz	NNP
cord-007444-c9vu8ako	165	15	-	-	HYPH
cord-007444-c9vu8ako	165	16	induced	induce	VBN
cord-007444-c9vu8ako	165	17	hypercarbia	hypercarbia	NN
cord-007444-c9vu8ako	165	18	is	be	VBZ
cord-007444-c9vu8ako	165	19	V	V	NNP
cord-007444-c9vu8ako	165	20	/	/	SYM
cord-007444-c9vu8ako	165	21	Q	q	NN
cord-007444-c9vu8ako	165	22	mismatching	mismatching	NN
cord-007444-c9vu8ako	165	23	,	,	,
cord-007444-c9vu8ako	165	24	perhaps	perhaps	RB
cord-007444-c9vu8ako	165	25	through	through	IN
cord-007444-c9vu8ako	165	26	the	the	DT
cord-007444-c9vu8ako	165	27	loss	loss	NN
cord-007444-c9vu8ako	165	28	of	of	IN
cord-007444-c9vu8ako	165	29	hypoxic	hypoxic	JJ
cord-007444-c9vu8ako	165	30	vasoconstriction	vasoconstriction	NN
cord-007444-c9vu8ako	165	31	.	.	.
cord-007444-c9vu8ako	166	1	More	More	JJR
cord-007444-c9vu8ako	166	2	recent	recent	JJ
cord-007444-c9vu8ako	166	3	work	work	NN
cord-007444-c9vu8ako	166	4	by	by	IN
cord-007444-c9vu8ako	166	5	Dunn	Dunn	NNP
cord-007444-c9vu8ako	166	6	et	et	NNP
cord-007444-c9vu8ako	166	7	a139	a139	NNP
cord-007444-c9vu8ako	166	8	and	and	CC
cord-007444-c9vu8ako	166	9	Stradling119	Stradling119	NNP
cord-007444-c9vu8ako	166	10	has	have	VBZ
cord-007444-c9vu8ako	166	11	challenged	challenge	VBN
cord-007444-c9vu8ako	166	12	Aubier	Aubier	NNP
cord-007444-c9vu8ako	166	13	's	's	POS
cord-007444-c9vu8ako	166	14	conclusions	conclusion	NNS
cord-007444-c9vu8ako	166	15	and	and	CC
cord-007444-c9vu8ako	166	16	defended	defend	VBD
cord-007444-c9vu8ako	166	17	the	the	DT
cord-007444-c9vu8ako	166	18	traditional	traditional	JJ
cord-007444-c9vu8ako	166	19	concept	concept	NN
cord-007444-c9vu8ako	166	20	that	that	IN
cord-007444-c9vu8ako	166	21	hypoventilation	hypoventilation	NN
cord-007444-c9vu8ako	166	22	,	,	,
cord-007444-c9vu8ako	166	23	rather	rather	RB
cord-007444-c9vu8ako	166	24	than	than	IN
cord-007444-c9vu8ako	166	25	V	v	NN
cord-007444-c9vu8ako	166	26	/	/	SYM
cord-007444-c9vu8ako	166	27	Q	q	NN
cord-007444-c9vu8ako	166	28	mismatching	mismatching	NN
cord-007444-c9vu8ako	166	29	,	,	,
cord-007444-c9vu8ako	166	30	is	be	VBZ
cord-007444-c9vu8ako	166	31	to	to	TO
cord-007444-c9vu8ako	166	32	blame	blame	VB
cord-007444-c9vu8ako	166	33	for	for	IN
cord-007444-c9vu8ako	166	34	0,-induced	0,-induced	NNP
cord-007444-c9vu8ako	166	35	hypercarbia	hypercarbia	NNP
cord-007444-c9vu8ako	166	36	.	.	.
cord-007444-c9vu8ako	167	1	One	one	CD
cord-007444-c9vu8ako	167	2	further	further	JJ
cord-007444-c9vu8ako	167	3	mechanism	mechanism	NN
cord-007444-c9vu8ako	167	4	that	that	WDT
cord-007444-c9vu8ako	167	5	appears	appear	VBZ
cord-007444-c9vu8ako	167	6	to	to	TO
cord-007444-c9vu8ako	167	7	contribute	contribute	VB
cord-007444-c9vu8ako	167	8	,	,	,
cord-007444-c9vu8ako	167	9	albeit	albeit	IN
cord-007444-c9vu8ako	167	10	to	to	IN
cord-007444-c9vu8ako	167	11	a	a	DT
cord-007444-c9vu8ako	167	12	minor	minor	JJ
cord-007444-c9vu8ako	167	13	extent	extent	NN
cord-007444-c9vu8ako	167	14	,	,	,
cord-007444-c9vu8ako	167	15	is	be	VBZ
cord-007444-c9vu8ako	167	16	the	the	DT
cord-007444-c9vu8ako	167	17	Haldane	Haldane	NNP
cord-007444-c9vu8ako	167	18	effect	effect	NN
cord-007444-c9vu8ako	167	19	,	,	,
cord-007444-c9vu8ako	167	20	whereby	whereby	WRB
cord-007444-c9vu8ako	167	21	CO	CO	NNP
cord-007444-c9vu8ako	167	22	,	,	,
cord-007444-c9vu8ako	167	23	is	be	VBZ
cord-007444-c9vu8ako	167	24	displaced	displace	VBN
cord-007444-c9vu8ako	167	25	from	from	IN
cord-007444-c9vu8ako	167	26	hemoglobin	hemoglobin	NN
cord-007444-c9vu8ako	167	27	by	by	IN
cord-007444-c9vu8ako	167	28	0	0	CD
cord-007444-c9vu8ako	167	29	,	,	,
cord-007444-c9vu8ako	167	30	causing	cause	VBG
cord-007444-c9vu8ako	167	31	a	a	DT
cord-007444-c9vu8ako	167	32	rise	rise	NN
cord-007444-c9vu8ako	167	33	in	in	IN
cord-007444-c9vu8ako	167	34	P	p	NN
cord-007444-c9vu8ako	167	35	~	~	CD
cord-007444-c9vu8ako	167	36	c	c	NN
cord-007444-c9vu8ako	167	37	o	o	NN
cord-007444-c9vu8ako	167	38	,	,	,
cord-007444-c9vu8ako	167	39	.~~~	.~~~	.
cord-007444-c9vu8ako	168	1	Nevertheless	nevertheless	RB
cord-007444-c9vu8ako	168	2	,	,	,
cord-007444-c9vu8ako	168	3	the	the	DT
cord-007444-c9vu8ako	168	4	risks	risk	NNS
cord-007444-c9vu8ako	168	5	for	for	IN
cord-007444-c9vu8ako	168	6	acute	acute	JJ
cord-007444-c9vu8ako	168	7	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	168	8	far	far	RB
cord-007444-c9vu8ako	168	9	outweigh	outweigh	VBP
cord-007444-c9vu8ako	168	10	the	the	DT
cord-007444-c9vu8ako	168	11	risks	risk	NNS
cord-007444-c9vu8ako	168	12	for	for	IN
cord-007444-c9vu8ako	168	13	severe	severe	JJ
cord-007444-c9vu8ako	168	14	hypercarbia	hypercarbia	NN
cord-007444-c9vu8ako	168	15	.	.	.
cord-007444-c9vu8ako	169	1	As	as	IN
cord-007444-c9vu8ako	169	2	such	such	JJ
cord-007444-c9vu8ako	169	3	,	,	,
cord-007444-c9vu8ako	169	4	supplemental	supplemental	JJ
cord-007444-c9vu8ako	169	5	0	0	CD
cord-007444-c9vu8ako	169	6	,	,	,
cord-007444-c9vu8ako	169	7	administration	administration	NN
cord-007444-c9vu8ako	169	8	is	be	VBZ
cord-007444-c9vu8ako	169	9	recommended	recommend	VBN
cord-007444-c9vu8ako	169	10	for	for	IN
cord-007444-c9vu8ako	169	11	hypoxemic	hypoxemic	JJ
cord-007444-c9vu8ako	169	12	patients	patient	NNS
cord-007444-c9vu8ako	169	13	with	with	IN
cord-007444-c9vu8ako	169	14	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	169	15	.	.	.
cord-007444-c9vu8ako	170	1	Oxygen	oxygen	NN
cord-007444-c9vu8ako	170	2	initially	initially	RB
cord-007444-c9vu8ako	170	3	should	should	MD
cord-007444-c9vu8ako	170	4	be	be	VB
cord-007444-c9vu8ako	170	5	given	give	VBN
cord-007444-c9vu8ako	170	6	to	to	IN
cord-007444-c9vu8ako	170	7	any	any	DT
cord-007444-c9vu8ako	170	8	hypoxemic	hypoxemic	JJ
cord-007444-c9vu8ako	170	9	patient	patient	NN
cord-007444-c9vu8ako	170	10	with	with	IN
cord-007444-c9vu8ako	170	11	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	170	12	by	by	IN
cord-007444-c9vu8ako	170	13	nasal	nasal	NN
cord-007444-c9vu8ako	170	14	cannulae	cannulae	NNS
cord-007444-c9vu8ako	170	15	or	or	CC
cord-007444-c9vu8ako	170	16	Venturi	Venturi	NNP
cord-007444-c9vu8ako	170	17	mask	mask	NN
cord-007444-c9vu8ako	170	18	.	.	.
cord-007444-c9vu8ako	171	1	If	if	IN
cord-007444-c9vu8ako	171	2	nasal	nasal	NN
cord-007444-c9vu8ako	171	3	cannulae	cannulae	NNS
cord-007444-c9vu8ako	171	4	are	be	VBP
cord-007444-c9vu8ako	171	5	used	use	VBN
cord-007444-c9vu8ako	171	6	,	,	,
cord-007444-c9vu8ako	171	7	flow	flow	NN
cord-007444-c9vu8ako	171	8	rates	rate	NNS
cord-007444-c9vu8ako	171	9	of	of	IN
cord-007444-c9vu8ako	171	10	1	1	CD
cord-007444-c9vu8ako	171	11	to	to	IN
cord-007444-c9vu8ako	171	12	2	2	CD
cord-007444-c9vu8ako	171	13	L	l	NN
cord-007444-c9vu8ako	171	14	/	/	SYM
cord-007444-c9vu8ako	171	15	minute	minute	NN
cord-007444-c9vu8ako	171	16	generally	generally	RB
cord-007444-c9vu8ako	171	17	suffice	suffice	VBP
cord-007444-c9vu8ako	171	18	.	.	.
cord-007444-c9vu8ako	172	1	The	the	DT
cord-007444-c9vu8ako	172	2	inspired	inspire	VBN
cord-007444-c9vu8ako	172	3	concentration	concentration	NN
cord-007444-c9vu8ako	172	4	of	of	IN
cord-007444-c9vu8ako	172	5	oxygen	oxygen	NN
cord-007444-c9vu8ako	172	6	(	(	-LRB-
cord-007444-c9vu8ako	172	7	Fio	Fio	NNP
cord-007444-c9vu8ako	172	8	,	,	,
cord-007444-c9vu8ako	172	9	)	)	-RRB-
cord-007444-c9vu8ako	172	10	usually	usually	RB
cord-007444-c9vu8ako	172	11	increases	increase	VBZ
cord-007444-c9vu8ako	172	12	by	by	IN
cord-007444-c9vu8ako	172	13	3	3	CD
cord-007444-c9vu8ako	172	14	%	%	NN
cord-007444-c9vu8ako	172	15	to	to	TO
cord-007444-c9vu8ako	172	16	4	4	CD
cord-007444-c9vu8ako	172	17	%	%	NN
cord-007444-c9vu8ako	172	18	for	for	IN
cord-007444-c9vu8ako	172	19	each	each	DT
cord-007444-c9vu8ako	172	20	increase	increase	NN
cord-007444-c9vu8ako	172	21	of	of	IN
cord-007444-c9vu8ako	172	22	1	1	CD
cord-007444-c9vu8ako	172	23	L	l	NN
cord-007444-c9vu8ako	172	24	/	/	SYM
cord-007444-c9vu8ako	172	25	minute	minute	NN
cord-007444-c9vu8ako	172	26	in	in	IN
cord-007444-c9vu8ako	172	27	flow	flow	NN
cord-007444-c9vu8ako	172	28	but	but	CC
cord-007444-c9vu8ako	172	29	varies	vary	VBZ
cord-007444-c9vu8ako	172	30	according	accord	VBG
cord-007444-c9vu8ako	172	31	to	to	IN
cord-007444-c9vu8ako	172	32	the	the	DT
cord-007444-c9vu8ako	172	33	patient	patient	NN
cord-007444-c9vu8ako	172	34	's	's	POS
cord-007444-c9vu8ako	172	35	own	own	JJ
cord-007444-c9vu8ako	172	36	inspiratory	inspiratory	JJ
cord-007444-c9vu8ako	172	37	flow	flow	NN
cord-007444-c9vu8ako	172	38	rate	rate	NN
cord-007444-c9vu8ako	172	39	.	.	.
cord-007444-c9vu8ako	173	1	Venturi	venturi	NN
cord-007444-c9vu8ako	173	2	masks	mask	NNS
cord-007444-c9vu8ako	173	3	are	be	VBP
cord-007444-c9vu8ako	173	4	more	more	RBR
cord-007444-c9vu8ako	173	5	precise	precise	JJ
cord-007444-c9vu8ako	173	6	and	and	CC
cord-007444-c9vu8ako	173	7	should	should	MD
cord-007444-c9vu8ako	173	8	initially	initially	RB
cord-007444-c9vu8ako	173	9	be	be	VB
cord-007444-c9vu8ako	173	10	set	set	VBN
cord-007444-c9vu8ako	173	11	to	to	TO
cord-007444-c9vu8ako	173	12	deliver	deliver	VB
cord-007444-c9vu8ako	173	13	a	a	DT
cord-007444-c9vu8ako	173	14	Fio	Fio	NNP
cord-007444-c9vu8ako	173	15	,	,	,
cord-007444-c9vu8ako	173	16	of	of	IN
cord-007444-c9vu8ako	173	17	24	24	CD
cord-007444-c9vu8ako	173	18	%	%	NN
cord-007444-c9vu8ako	173	19	to	to	IN
cord-007444-c9vu8ako	173	20	28	28	CD
cord-007444-c9vu8ako	173	21	%	%	NN
cord-007444-c9vu8ako	173	22	.	.	.
cord-007444-c9vu8ako	174	1	On	on	IN
cord-007444-c9vu8ako	174	2	average	average	JJ
cord-007444-c9vu8ako	174	3	,	,	,
cord-007444-c9vu8ako	174	4	the	the	DT
cord-007444-c9vu8ako	174	5	Pao	Pao	NNP
cord-007444-c9vu8ako	174	6	,	,	,
cord-007444-c9vu8ako	174	7	increases	increase	NNS
cord-007444-c9vu8ako	174	8	by	by	IN
cord-007444-c9vu8ako	174	9	10	10	CD
cord-007444-c9vu8ako	174	10	mm	mm	NN
cord-007444-c9vu8ako	174	11	Hg	hg	NN
cord-007444-c9vu8ako	174	12	when	when	WRB
cord-007444-c9vu8ako	174	13	the	the	DT
cord-007444-c9vu8ako	174	14	Fio	Fio	NNP
cord-007444-c9vu8ako	174	15	,	,	,
cord-007444-c9vu8ako	174	16	is	be	VBZ
cord-007444-c9vu8ako	174	17	increased	increase	VBN
cord-007444-c9vu8ako	174	18	from	from	IN
cord-007444-c9vu8ako	174	19	room	room	NN
cord-007444-c9vu8ako	174	20	air	air	NN
cord-007444-c9vu8ako	174	21	to	to	IN
cord-007444-c9vu8ako	174	22	24	24	CD
cord-007444-c9vu8ako	174	23	%	%	NN
cord-007444-c9vu8ako	174	24	,	,	,
cord-007444-c9vu8ako	174	25	and	and	CC
cord-007444-c9vu8ako	174	26	by	by	IN
cord-007444-c9vu8ako	174	27	20	20	CD
cord-007444-c9vu8ako	174	28	mm	mm	NN
cord-007444-c9vu8ako	174	29	Hg	hg	NN
cord-007444-c9vu8ako	174	30	when	when	WRB
cord-007444-c9vu8ako	174	31	the	the	DT
cord-007444-c9vu8ako	174	32	Fio	Fio	NNP
cord-007444-c9vu8ako	174	33	,	,	,
cord-007444-c9vu8ako	174	34	is	be	VBZ
cord-007444-c9vu8ako	174	35	increased	increase	VBN
cord-007444-c9vu8ako	174	36	to	to	IN
cord-007444-c9vu8ako	174	37	28%.17	28%.17	CD
cord-007444-c9vu8ako	175	1	The	the	DT
cord-007444-c9vu8ako	175	2	target	target	NN
cord-007444-c9vu8ako	175	3	Pao	Pao	NNP
cord-007444-c9vu8ako	175	4	,	,	,
cord-007444-c9vu8ako	175	5	is	be	VBZ
cord-007444-c9vu8ako	176	1	between	between	IN
cord-007444-c9vu8ako	176	2	60	60	CD
cord-007444-c9vu8ako	176	3	and	and	CC
cord-007444-c9vu8ako	176	4	70	70	CD
cord-007444-c9vu8ako	176	5	mm	mm	NN
cord-007444-c9vu8ako	176	6	Hg	Hg	NNP
cord-007444-c9vu8ako	176	7	,	,	,
cord-007444-c9vu8ako	176	8	corresponding	correspond	VBG
cord-007444-c9vu8ako	176	9	to	to	IN
cord-007444-c9vu8ako	176	10	the	the	DT
cord-007444-c9vu8ako	176	11	Pao	Pao	NNP
cord-007444-c9vu8ako	176	12	,	,	,
cord-007444-c9vu8ako	176	13	at	at	IN
cord-007444-c9vu8ako	176	14	which	which	WDT
cord-007444-c9vu8ako	176	15	there	there	EX
cord-007444-c9vu8ako	176	16	is	be	VBZ
cord-007444-c9vu8ako	176	17	near	near	RB
cord-007444-c9vu8ako	176	18	-	-	HYPH
cord-007444-c9vu8ako	176	19	complete	complete	JJ
cord-007444-c9vu8ako	176	20	saturation	saturation	NN
cord-007444-c9vu8ako	176	21	of	of	IN
cord-007444-c9vu8ako	176	22	hemoglobin	hemoglobin	NN
cord-007444-c9vu8ako	176	23	with	with	IN
cord-007444-c9vu8ako	176	24	0	0	CD
cord-007444-c9vu8ako	176	25	,	,	,
cord-007444-c9vu8ako	176	26	.	.	.
cord-007444-c9vu8ako	177	1	Rarely	rarely	RB
cord-007444-c9vu8ako	177	2	,	,	,
cord-007444-c9vu8ako	177	3	overzealous	overzealous	JJ
cord-007444-c9vu8ako	177	4	0	0	CD
cord-007444-c9vu8ako	177	5	,	,	,
cord-007444-c9vu8ako	177	6	administration	administration	NN
cord-007444-c9vu8ako	177	7	produces	produce	VBZ
cord-007444-c9vu8ako	177	8	progressive	progressive	JJ
cord-007444-c9vu8ako	177	9	hypercapnia	hypercapnia	NN
cord-007444-c9vu8ako	177	10	and	and	CC
cord-007444-c9vu8ako	177	11	respiratory	respiratory	JJ
cord-007444-c9vu8ako	177	12	acidosis.2o	acidosis.2o	NN
cord-007444-c9vu8ako	177	13	,	,	,
cord-007444-c9vu8ako	177	14	34	34	CD
cord-007444-c9vu8ako	177	15	,	,	,
cord-007444-c9vu8ako	177	16	74	74	CD
cord-007444-c9vu8ako	177	17	For	for	IN
cord-007444-c9vu8ako	177	18	this	this	DT
cord-007444-c9vu8ako	177	19	reason	reason	NN
cord-007444-c9vu8ako	177	20	,	,	,
cord-007444-c9vu8ako	177	21	response	response	NN
cord-007444-c9vu8ako	177	22	to	to	IN
cord-007444-c9vu8ako	177	23	0	0	CD
cord-007444-c9vu8ako	177	24	,	,	,
cord-007444-c9vu8ako	177	25	must	must	MD
cord-007444-c9vu8ako	177	26	be	be	VB
cord-007444-c9vu8ako	177	27	assessed	assess	VBN
cord-007444-c9vu8ako	177	28	according	accord	VBG
cord-007444-c9vu8ako	177	29	to	to	IN
cord-007444-c9vu8ako	177	30	arterial	arterial	JJ
cord-007444-c9vu8ako	177	31	blood	blood	NN
cord-007444-c9vu8ako	177	32	gas	gas	NN
cord-007444-c9vu8ako	177	33	and	and	CC
cord-007444-c9vu8ako	177	34	pH	ph	NN
cord-007444-c9vu8ako	177	35	measurements	measurement	NNS
cord-007444-c9vu8ako	177	36	.	.	.
cord-007444-c9vu8ako	178	1	These	these	DT
cord-007444-c9vu8ako	178	2	should	should	MD
cord-007444-c9vu8ako	178	3	be	be	VB
cord-007444-c9vu8ako	178	4	obtained	obtain	VBN
cord-007444-c9vu8ako	178	5	at	at	IN
cord-007444-c9vu8ako	178	6	baseline	baseline	NN
cord-007444-c9vu8ako	178	7	and	and	CC
cord-007444-c9vu8ako	178	8	within	within	IN
cord-007444-c9vu8ako	178	9	60	60	CD
cord-007444-c9vu8ako	178	10	minutes	minute	NNS
cord-007444-c9vu8ako	178	11	of	of	IN
cord-007444-c9vu8ako	178	12	starting	start	VBG
cord-007444-c9vu8ako	178	13	or	or	CC
cord-007444-c9vu8ako	178	14	changing	change	VBG
cord-007444-c9vu8ako	178	15	the	the	DT
cord-007444-c9vu8ako	178	16	0	0	CD
cord-007444-c9vu8ako	178	17	,	,	,
cord-007444-c9vu8ako	178	18	concentration	concentration	NN
cord-007444-c9vu8ako	178	19	.	.	.
cord-007444-c9vu8ako	179	1	If	if	IN
cord-007444-c9vu8ako	179	2	Pao	Pao	NNP
cord-007444-c9vu8ako	179	3	,	,	,
cord-007444-c9vu8ako	179	4	remains	remain	VBZ
cord-007444-c9vu8ako	179	5	intractably	intractably	RB
cord-007444-c9vu8ako	179	6	low	low	JJ
cord-007444-c9vu8ako	179	7	or	or	CC
cord-007444-c9vu8ako	179	8	the	the	DT
cord-007444-c9vu8ako	179	9	pH	pH	NNP
cord-007444-c9vu8ako	179	10	drops	drop	VBZ
cord-007444-c9vu8ako	179	11	as	as	IN
cord-007444-c9vu8ako	179	12	a	a	DT
cord-007444-c9vu8ako	179	13	result	result	NN
cord-007444-c9vu8ako	179	14	of	of	IN
cord-007444-c9vu8ako	179	15	increasing	increase	VBG
cord-007444-c9vu8ako	179	16	Paco	Paco	NNP
cord-007444-c9vu8ako	179	17	,	,	,
cord-007444-c9vu8ako	179	18	alternate	alternate	JJ
cord-007444-c9vu8ako	179	19	strategies	strategy	NNS
cord-007444-c9vu8ako	179	20	to	to	TO
cord-007444-c9vu8ako	179	21	improve	improve	VB
cord-007444-c9vu8ako	179	22	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	179	23	and	and	CC
cord-007444-c9vu8ako	179	24	respiratory	respiratory	JJ
cord-007444-c9vu8ako	179	25	acidosis	acidosis	NN
cord-007444-c9vu8ako	179	26	must	must	MD
cord-007444-c9vu8ako	179	27	be	be	VB
cord-007444-c9vu8ako	179	28	devised	devise	VBN
cord-007444-c9vu8ako	179	29	.	.	.
cord-007444-c9vu8ako	180	1	These	these	DT
cord-007444-c9vu8ako	180	2	include	include	VBP
cord-007444-c9vu8ako	180	3	maximizing	maximize	VBG
cord-007444-c9vu8ako	180	4	bronchodilation	bronchodilation	NN
cord-007444-c9vu8ako	180	5	and	and	CC
cord-007444-c9vu8ako	180	6	the	the	DT
cord-007444-c9vu8ako	180	7	use	use	NN
cord-007444-c9vu8ako	180	8	of	of	IN
cord-007444-c9vu8ako	180	9	assisted	assist	VBN
cord-007444-c9vu8ako	180	10	ventilation	ventilation	NN
cord-007444-c9vu8ako	180	11	.	.	.
cord-007444-c9vu8ako	181	1	The	the	DT
cord-007444-c9vu8ako	181	2	role	role	NN
cord-007444-c9vu8ako	181	3	of	of	IN
cord-007444-c9vu8ako	181	4	bronchodilators	bronchodilator	NNS
cord-007444-c9vu8ako	181	5	in	in	IN
cord-007444-c9vu8ako	181	6	the	the	DT
cord-007444-c9vu8ako	181	7	management	management	NN
cord-007444-c9vu8ako	181	8	of	of	IN
cord-007444-c9vu8ako	181	9	stable	stable	JJ
cord-007444-c9vu8ako	181	10	COPD	COPD	NNP
cord-007444-c9vu8ako	181	11	is	be	VBZ
cord-007444-c9vu8ako	181	12	discussed	discuss	VBN
cord-007444-c9vu8ako	181	13	in	in	IN
cord-007444-c9vu8ako	181	14	the	the	DT
cord-007444-c9vu8ako	181	15	article	article	NN
cord-007444-c9vu8ako	181	16	by	by	IN
cord-007444-c9vu8ako	181	17	Ferguson	Ferguson	NNP
cord-007444-c9vu8ako	181	18	on	on	IN
cord-007444-c9vu8ako	181	19	pharmacologic	pharmacologic	JJ
cord-007444-c9vu8ako	181	20	therapy	therapy	NN
cord-007444-c9vu8ako	181	21	for	for	IN
cord-007444-c9vu8ako	181	22	COPD	COPD	NNP
cord-007444-c9vu8ako	181	23	.	.	.
cord-007444-c9vu8ako	182	1	Bronchodilator	Bronchodilator	NNP
cord-007444-c9vu8ako	182	2	agents	agent	NNS
cord-007444-c9vu8ako	182	3	,	,	,
cord-007444-c9vu8ako	182	4	specifically	specifically	RB
cord-007444-c9vu8ako	182	5	p,-agonists	p,-agonists	NNPS
cord-007444-c9vu8ako	182	6	and	and	CC
cord-007444-c9vu8ako	182	7	ipratropium	ipratropium	NN
cord-007444-c9vu8ako	182	8	bromide	bromide	NN
cord-007444-c9vu8ako	182	9	(	(	-LRB-
cord-007444-c9vu8ako	182	10	IB	IB	NNP
cord-007444-c9vu8ako	182	11	)	)	-RRB-
cord-007444-c9vu8ako	182	12	,	,	,
cord-007444-c9vu8ako	182	13	also	also	RB
cord-007444-c9vu8ako	182	14	play	play	VBP
cord-007444-c9vu8ako	182	15	a	a	DT
cord-007444-c9vu8ako	182	16	central	central	JJ
cord-007444-c9vu8ako	182	17	role	role	NN
cord-007444-c9vu8ako	182	18	in	in	IN
cord-007444-c9vu8ako	182	19	the	the	DT
cord-007444-c9vu8ako	182	20	management	management	NN
cord-007444-c9vu8ako	182	21	of	of	IN
cord-007444-c9vu8ako	182	22	patients	patient	NNS
cord-007444-c9vu8ako	182	23	with	with	IN
cord-007444-c9vu8ako	182	24	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	182	25	,	,	,
cord-007444-c9vu8ako	182	26	with	with	IN
cord-007444-c9vu8ako	182	27	and	and	CC
cord-007444-c9vu8ako	182	28	without	without	IN
cord-007444-c9vu8ako	182	29	respiratory	respiratory	JJ
cord-007444-c9vu8ako	182	30	failure	failure	NN
cord-007444-c9vu8ako	182	31	.	.	.
cord-007444-c9vu8ako	183	1	These	these	DT
cord-007444-c9vu8ako	183	2	agents	agent	NNS
cord-007444-c9vu8ako	183	3	are	be	VBP
cord-007444-c9vu8ako	183	4	generally	generally	RB
cord-007444-c9vu8ako	183	5	given	give	VBN
cord-007444-c9vu8ako	183	6	by	by	IN
cord-007444-c9vu8ako	183	7	inhalation	inhalation	NN
cord-007444-c9vu8ako	183	8	to	to	TO
cord-007444-c9vu8ako	183	9	reduce	reduce	VB
cord-007444-c9vu8ako	183	10	side	side	NN
cord-007444-c9vu8ako	183	11	-	-	HYPH
cord-007444-c9vu8ako	183	12	effects	effect	NNS
cord-007444-c9vu8ako	183	13	and	and	CC
cord-007444-c9vu8ako	183	14	,	,	,
cord-007444-c9vu8ako	183	15	in	in	IN
cord-007444-c9vu8ako	183	16	the	the	DT
cord-007444-c9vu8ako	183	17	acute	acute	JJ
cord-007444-c9vu8ako	183	18	setting	setting	NN
cord-007444-c9vu8ako	183	19	,	,	,
cord-007444-c9vu8ako	183	20	nebulizers	nebulizer	NNS
cord-007444-c9vu8ako	183	21	have	have	VBP
cord-007444-c9vu8ako	183	22	been	be	VBN
cord-007444-c9vu8ako	183	23	traditionally	traditionally	RB
cord-007444-c9vu8ako	183	24	preferred	prefer	VBN
cord-007444-c9vu8ako	183	25	over	over	IN
cord-007444-c9vu8ako	183	26	metered	meter	VBN
cord-007444-c9vu8ako	183	27	-	-	HYPH
cord-007444-c9vu8ako	183	28	dose	dose	NN
cord-007444-c9vu8ako	183	29	inhalers	inhaler	NNS
cord-007444-c9vu8ako	183	30	(	(	-LRB-
cord-007444-c9vu8ako	183	31	MDIs	mdi	NNS
cord-007444-c9vu8ako	183	32	)	)	-RRB-
cord-007444-c9vu8ako	183	33	for	for	IN
cord-007444-c9vu8ako	183	34	ease	ease	NN
cord-007444-c9vu8ako	183	35	of	of	IN
cord-007444-c9vu8ako	183	36	drug	drug	NN
cord-007444-c9vu8ako	183	37	administration.68	administration.68	NN
cord-007444-c9vu8ako	183	38	,	,	,
cord-007444-c9vu8ako	183	39	74	74	CD
cord-007444-c9vu8ako	183	40	*	*	NFP
cord-007444-c9vu8ako	184	1	Although	although	IN
cord-007444-c9vu8ako	184	2	there	there	EX
cord-007444-c9vu8ako	184	3	are	be	VBP
cord-007444-c9vu8ako	184	4	few	few	JJ
cord-007444-c9vu8ako	184	5	data	datum	NNS
cord-007444-c9vu8ako	184	6	to	to	TO
cord-007444-c9vu8ako	184	7	support	support	VB
cord-007444-c9vu8ako	184	8	the	the	DT
cord-007444-c9vu8ako	184	9	choice	choice	NN
cord-007444-c9vu8ako	184	10	of	of	IN
cord-007444-c9vu8ako	184	11	either	either	DT
cord-007444-c9vu8ako	184	12	P,-agonists	p,-agonist	NNS
cord-007444-c9vu8ako	184	13	or	or	CC
cord-007444-c9vu8ako	184	14	IB	IB	NNP
cord-007444-c9vu8ako	184	15	as	as	IN
cord-007444-c9vu8ako	184	16	first	first	JJ
cord-007444-c9vu8ako	184	17	-	-	HYPH
cord-007444-c9vu8ako	184	18	line	line	NN
cord-007444-c9vu8ako	184	19	therapy	therapy	NN
cord-007444-c9vu8ako	184	20	for	for	IN
cord-007444-c9vu8ako	184	21	acute	acute	JJ
cord-007444-c9vu8ako	184	22	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	184	23	,	,	,
cord-007444-c9vu8ako	184	24	P,-agonists	p,-agonist	NNS
cord-007444-c9vu8ako	184	25	are	be	VBP
cord-007444-c9vu8ako	184	26	usually	usually	RB
cord-007444-c9vu8ako	184	27	given	give	VBN
cord-007444-c9vu8ako	184	28	as	as	IN
cord-007444-c9vu8ako	184	29	the	the	DT
cord-007444-c9vu8ako	184	30	first	first	JJ
cord-007444-c9vu8ako	184	31	step	step	NN
cord-007444-c9vu8ako	184	32	,	,	,
cord-007444-c9vu8ako	184	33	perhaps	perhaps	RB
cord-007444-c9vu8ako	184	34	because	because	IN
cord-007444-c9vu8ako	184	35	of	of	IN
cord-007444-c9vu8ako	184	36	the	the	DT
cord-007444-c9vu8ako	184	37	longer	long	JJR
cord-007444-c9vu8ako	184	38	time	time	NN
cord-007444-c9vu8ako	184	39	to	to	TO
cord-007444-c9vu8ako	184	40	peak	peak	VB
cord-007444-c9vu8ako	184	41	effect	effect	NN
cord-007444-c9vu8ako	184	42	for	for	IN
cord-007444-c9vu8ako	184	43	IB.7,73	IB.7,73	NNP
cord-007444-c9vu8ako	185	1	When	when	WRB
cord-007444-c9vu8ako	185	2	given	give	VBN
cord-007444-c9vu8ako	185	3	in	in	IN
cord-007444-c9vu8ako	185	4	recommended	recommend	VBN
cord-007444-c9vu8ako	185	5	doses	dose	NNS
cord-007444-c9vu8ako	185	6	(	(	-LRB-
cord-007444-c9vu8ako	185	7	two	two	CD
cord-007444-c9vu8ako	185	8	puffs	puff	NNS
cord-007444-c9vu8ako	185	9	)	)	-RRB-
cord-007444-c9vu8ako	185	10	,	,	,
cord-007444-c9vu8ako	185	11	IB	IB	NNP
cord-007444-c9vu8ako	185	12	generally	generally	RB
cord-007444-c9vu8ako	185	13	produces	produce	VBZ
cord-007444-c9vu8ako	185	14	greater	great	JJR
cord-007444-c9vu8ako	185	15	bronchodilation	bronchodilation	NN
cord-007444-c9vu8ako	185	16	than	than	IN
cord-007444-c9vu8ako	185	17	p,-agoni	p,-agoni	NNP
cord-007444-c9vu8ako	185	18	~	~	NFP
cord-007444-c9vu8ako	185	19	ts.~~	ts.~~	NN
cord-007444-c9vu8ako	185	20	,	,	,
cord-007444-c9vu8ako	185	21	Ipratropium	Ipratropium	NNP
cord-007444-c9vu8ako	185	22	bromide	bromide	NN
cord-007444-c9vu8ako	185	23	and	and	CC
cord-007444-c9vu8ako	185	24	p,-agonists	p,-agonist	NNS
cord-007444-c9vu8ako	185	25	are	be	VBP
cord-007444-c9vu8ako	185	26	often	often	RB
cord-007444-c9vu8ako	185	27	used	use	VBN
cord-007444-c9vu8ako	185	28	together	together	RB
cord-007444-c9vu8ako	185	29	in	in	IN
cord-007444-c9vu8ako	185	30	the	the	DT
cord-007444-c9vu8ako	185	31	acute	acute	JJ
cord-007444-c9vu8ako	185	32	setting	setting	NN
cord-007444-c9vu8ako	185	33	,	,	,
cord-007444-c9vu8ako	185	34	despite	despite	IN
cord-007444-c9vu8ako	185	35	a	a	DT
cord-007444-c9vu8ako	185	36	lack	lack	NN
cord-007444-c9vu8ako	185	37	of	of	IN
cord-007444-c9vu8ako	185	38	evidence	evidence	NN
cord-007444-c9vu8ako	185	39	from	from	IN
cord-007444-c9vu8ako	185	40	randomized	randomize	VBN
cord-007444-c9vu8ako	185	41	-	-	HYPH
cord-007444-c9vu8ako	185	42	controlled	control	VBN
cord-007444-c9vu8ako	185	43	trials	trial	NNS
cord-007444-c9vu8ako	185	44	that	that	IN
cord-007444-c9vu8ako	185	45	they	-PRON-	PRP
cord-007444-c9vu8ako	185	46	are	be	VBP
cord-007444-c9vu8ako	185	47	more	more	RBR
cord-007444-c9vu8ako	185	48	efficacious	efficacious	JJ
cord-007444-c9vu8ako	185	49	in	in	IN
cord-007444-c9vu8ako	185	50	tandem	tandem	NN
cord-007444-c9vu8ako	185	51	than	than	IN
cord-007444-c9vu8ako	185	52	either	either	DT
cord-007444-c9vu8ako	185	53	agent	agent	NN
cord-007444-c9vu8ako	185	54	alone	alone	RB
cord-007444-c9vu8ako	185	55	in	in	IN
cord-007444-c9vu8ako	185	56	that	that	DT
cord-007444-c9vu8ako	186	1	~e	~e	NNP
cord-007444-c9vu8ako	186	2	t	t	NNP
cord-007444-c9vu8ako	186	3	t	t	NN
cord-007444-c9vu8ako	187	1	i	i	PRP
cord-007444-c9vu8ako	187	2	n	n	CC
cord-007444-c9vu8ako	187	3	g	g	NN
cord-007444-c9vu8ako	187	4	.~~,~~,~~	.~~,~~,~~	.
cord-007444-c9vu8ako	188	1	In	in	IN
cord-007444-c9vu8ako	188	2	a	a	DT
cord-007444-c9vu8ako	188	3	doubleblind	doubleblind	NN
cord-007444-c9vu8ako	188	4	,	,	,
cord-007444-c9vu8ako	188	5	randomized	randomized	JJ
cord-007444-c9vu8ako	188	6	study	study	NN
cord-007444-c9vu8ako	188	7	involving	involve	VBG
cord-007444-c9vu8ako	188	8	51	51	CD
cord-007444-c9vu8ako	188	9	patients	patient	NNS
cord-007444-c9vu8ako	188	10	with	with	IN
cord-007444-c9vu8ako	188	11	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	188	12	,	,	,
cord-007444-c9vu8ako	188	13	the	the	DT
cord-007444-c9vu8ako	188	14	effects	effect	NNS
cord-007444-c9vu8ako	188	15	of	of	IN
cord-007444-c9vu8ako	188	16	0.5	0.5	CD
cord-007444-c9vu8ako	188	17	mg	mg	NNS
cord-007444-c9vu8ako	188	18	of	of	IN
cord-007444-c9vu8ako	188	19	IB	IB	NNP
cord-007444-c9vu8ako	188	20	,	,	,
cord-007444-c9vu8ako	188	21	1.25	1.25	CD
cord-007444-c9vu8ako	188	22	mg	mg	NNS
cord-007444-c9vu8ako	188	23	of	of	IN
cord-007444-c9vu8ako	188	24	fenoterol	fenoterol	NNP
cord-007444-c9vu8ako	188	25	,	,	,
cord-007444-c9vu8ako	188	26	or	or	CC
cord-007444-c9vu8ako	188	27	a	a	DT
cord-007444-c9vu8ako	188	28	combination	combination	NN
cord-007444-c9vu8ako	188	29	of	of	IN
cord-007444-c9vu8ako	188	30	the	the	DT
cord-007444-c9vu8ako	188	31	two	two	CD
cord-007444-c9vu8ako	188	32	agents	agent	NNS
cord-007444-c9vu8ako	188	33	were	be	VBD
cord-007444-c9vu8ako	188	34	compared	compare	VBN
cord-007444-c9vu8ako	188	35	.	.	.
cord-007444-c9vu8ako	189	1	All	all	DT
cord-007444-c9vu8ako	189	2	three	three	CD
cord-007444-c9vu8ako	189	3	regimens	regimen	NNS
cord-007444-c9vu8ako	189	4	resulted	result	VBD
cord-007444-c9vu8ako	189	5	in	in	IN
cord-007444-c9vu8ako	189	6	improved	improve	VBN
cord-007444-c9vu8ako	189	7	spirometric	spirometric	JJ
cord-007444-c9vu8ako	189	8	function	function	NN
cord-007444-c9vu8ako	189	9	at	at	IN
cord-007444-c9vu8ako	189	10	45	45	CD
cord-007444-c9vu8ako	189	11	and	and	CC
cord-007444-c9vu8ako	189	12	90	90	CD
cord-007444-c9vu8ako	189	13	minutes	minute	NNS
cord-007444-c9vu8ako	189	14	post	post	NN
cord-007444-c9vu8ako	189	15	-	-	NN
cord-007444-c9vu8ako	189	16	treatment	treatment	NN
cord-007444-c9vu8ako	189	17	,	,	,
cord-007444-c9vu8ako	189	18	but	but	CC
cord-007444-c9vu8ako	189	19	combination	combination	NN
cord-007444-c9vu8ako	189	20	therapy	therapy	NN
cord-007444-c9vu8ako	189	21	was	be	VBD
cord-007444-c9vu8ako	189	22	no	no	RB
cord-007444-c9vu8ako	189	23	better	well	JJR
cord-007444-c9vu8ako	189	24	than	than	IN
cord-007444-c9vu8ako	189	25	either	either	DT
cord-007444-c9vu8ako	189	26	agent	agent	NN
cord-007444-c9vu8ako	189	27	alone	alone	RB
cord-007444-c9vu8ako	189	28	.	.	.
cord-007444-c9vu8ako	190	1	Similarly	similarly	RB
cord-007444-c9vu8ako	190	2	,	,	,
cord-007444-c9vu8ako	190	3	ODriscoll	ODriscoll	NNP
cord-007444-c9vu8ako	190	4	et	et	NNP
cord-007444-c9vu8ako	190	5	alas	alas	NN
cord-007444-c9vu8ako	190	6	compared	compare	VBD
cord-007444-c9vu8ako	190	7	nebulized	nebulize	VBD
cord-007444-c9vu8ako	190	8	salbutamol	salbutamol	NN
cord-007444-c9vu8ako	190	9	(	(	-LRB-
cord-007444-c9vu8ako	190	10	10	10	CD
cord-007444-c9vu8ako	190	11	mg	mg	NNP
cord-007444-c9vu8ako	190	12	)	)	-RRB-
cord-007444-c9vu8ako	190	13	with	with	IN
cord-007444-c9vu8ako	190	14	and	and	CC
cord-007444-c9vu8ako	190	15	without	without	IN
cord-007444-c9vu8ako	190	16	IB	IB	NNP
cord-007444-c9vu8ako	190	17	(	(	-LRB-
cord-007444-c9vu8ako	190	18	0.5	0.5	CD
cord-007444-c9vu8ako	190	19	mg	mg	CD
cord-007444-c9vu8ako	190	20	)	)	-RRB-
cord-007444-c9vu8ako	190	21	in	in	IN
cord-007444-c9vu8ako	190	22	47	47	CD
cord-007444-c9vu8ako	190	23	patients	patient	NNS
cord-007444-c9vu8ako	190	24	with	with	IN
cord-007444-c9vu8ako	190	25	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	190	26	.	.	.
cord-007444-c9vu8ako	191	1	One	one	CD
cord-007444-c9vu8ako	191	2	hour	hour	NN
cord-007444-c9vu8ako	191	3	following	follow	VBG
cord-007444-c9vu8ako	191	4	treatment	treatment	NN
cord-007444-c9vu8ako	191	5	,	,	,
cord-007444-c9vu8ako	191	6	peak	peak	NN
cord-007444-c9vu8ako	191	7	expiratory	expiratory	JJ
cord-007444-c9vu8ako	191	8	flow	flow	NN
cord-007444-c9vu8ako	191	9	rates	rate	NNS
cord-007444-c9vu8ako	191	10	were	be	VBD
cord-007444-c9vu8ako	191	11	not	not	RB
cord-007444-c9vu8ako	191	12	significantly	significantly	RB
cord-007444-c9vu8ako	191	13	different	different	JJ
cord-007444-c9vu8ako	191	14	between	between	IN
cord-007444-c9vu8ako	191	15	regimens.89	regimens.89	NNP
cord-007444-c9vu8ako	191	16	Others	other	NNS
cord-007444-c9vu8ako	191	17	have	have	VBP
cord-007444-c9vu8ako	191	18	examined	examine	VBN
cord-007444-c9vu8ako	191	19	clinical	clinical	JJ
cord-007444-c9vu8ako	191	20	,	,	,
cord-007444-c9vu8ako	191	21	rather	rather	RB
cord-007444-c9vu8ako	191	22	than	than	IN
cord-007444-c9vu8ako	191	23	spirometric	spirometric	NNP
cord-007444-c9vu8ako	191	24	,	,	,
cord-007444-c9vu8ako	191	25	outcomes	outcome	NNS
cord-007444-c9vu8ako	191	26	following	follow	VBG
cord-007444-c9vu8ako	191	27	combined	combine	VBN
cord-007444-c9vu8ako	191	28	therapy	therapy	NN
cord-007444-c9vu8ako	191	29	in	in	IN
cord-007444-c9vu8ako	191	30	AECOPD.79	AECOPD.79	NNP
cord-007444-c9vu8ako	191	31	,	,	,
cord-007444-c9vu8ako	191	32	Patients	patient	NNS
cord-007444-c9vu8ako	191	33	randomly	randomly	RB
cord-007444-c9vu8ako	191	34	assigned	assign	VBN
cord-007444-c9vu8ako	191	35	to	to	IN
cord-007444-c9vu8ako	191	36	a	a	DT
cord-007444-c9vu8ako	191	37	combination	combination	NN
cord-007444-c9vu8ako	191	38	of	of	IN
cord-007444-c9vu8ako	191	39	isoetharine	isoetharine	NNP
cord-007444-c9vu8ako	191	40	and	and	CC
cord-007444-c9vu8ako	191	41	IB	IB	NNP
cord-007444-c9vu8ako	191	42	were	be	VBD
cord-007444-c9vu8ako	191	43	discharged	discharge	VBN
cord-007444-c9vu8ako	191	44	from	from	IN
cord-007444-c9vu8ako	191	45	the	the	DT
cord-007444-c9vu8ako	191	46	emergency	emergency	NN
cord-007444-c9vu8ako	191	47	department	department	NN
cord-007444-c9vu8ako	191	48	an	an	DT
cord-007444-c9vu8ako	191	49	average	average	NN
cord-007444-c9vu8ako	191	50	of	of	IN
cord-007444-c9vu8ako	191	51	90	90	CD
cord-007444-c9vu8ako	191	52	minutes	minute	NNS
cord-007444-c9vu8ako	191	53	sooner	soon	RBR
cord-007444-c9vu8ako	191	54	than	than	IN
cord-007444-c9vu8ako	191	55	those	those	DT
cord-007444-c9vu8ako	191	56	who	who	WP
cord-007444-c9vu8ako	191	57	received	receive	VBD
cord-007444-c9vu8ako	191	58	only	only	RB
cord-007444-c9vu8ako	191	59	isoetharine	isoetharine	NNP
cord-007444-c9vu8ako	191	60	.	.	.
cord-007444-c9vu8ako	192	1	The	the	DT
cord-007444-c9vu8ako	192	2	authors	author	NNS
cord-007444-c9vu8ako	192	3	attributed	attribute	VBD
cord-007444-c9vu8ako	192	4	this	this	DT
cord-007444-c9vu8ako	192	5	time	time	NN
cord-007444-c9vu8ako	192	6	saving	save	VBG
cord-007444-c9vu8ako	192	7	to	to	IN
cord-007444-c9vu8ako	192	8	approximately	approximately	RB
cord-007444-c9vu8ako	192	9	five	five	CD
cord-007444-c9vu8ako	192	10	puffs	puff	NNS
cord-007444-c9vu8ako	192	11	of	of	IN
cord-007444-c9vu8ako	192	12	IB	IB	NNP
cord-007444-c9vu8ako	192	13	.	.	.
cord-007444-c9vu8ako	193	1	Interestingly	interestingly	RB
cord-007444-c9vu8ako	193	2	,	,	,
cord-007444-c9vu8ako	193	3	mean	mean	JJ
cord-007444-c9vu8ako	193	4	discharge	discharge	NN
cord-007444-c9vu8ako	193	5	FEV	FEV	NNP
cord-007444-c9vu8ako	193	6	,	,	,
cord-007444-c9vu8ako	193	7	was	be	VBD
cord-007444-c9vu8ako	193	8	not	not	RB
cord-007444-c9vu8ako	193	9	different	different	JJ
cord-007444-c9vu8ako	193	10	between	between	IN
cord-007444-c9vu8ako	193	11	the	the	DT
cord-007444-c9vu8ako	193	12	two	two	CD
cord-007444-c9vu8ako	193	13	groups.11o	groups.11o	XX
cord-007444-c9vu8ako	194	1	Because	because	IN
cord-007444-c9vu8ako	194	2	these	these	DT
cord-007444-c9vu8ako	194	3	studies	study	NNS
cord-007444-c9vu8ako	194	4	followed	follow	VBD
cord-007444-c9vu8ako	194	5	patients	patient	NNS
cord-007444-c9vu8ako	194	6	for	for	IN
cord-007444-c9vu8ako	194	7	only	only	RB
cord-007444-c9vu8ako	194	8	60	60	CD
cord-007444-c9vu8ako	194	9	to	to	TO
cord-007444-c9vu8ako	194	10	90	90	CD
cord-007444-c9vu8ako	194	11	minutes	minute	NNS
cord-007444-c9vu8ako	194	12	,	,	,
cord-007444-c9vu8ako	194	13	Moayyedi	Moayyedi	NNP
cord-007444-c9vu8ako	194	14	et	et	NNP
cord-007444-c9vu8ako	194	15	a179	a179	NNP
cord-007444-c9vu8ako	194	16	recently	recently	RB
cord-007444-c9vu8ako	194	17	attempted	attempt	VBD
cord-007444-c9vu8ako	194	18	to	to	TO
cord-007444-c9vu8ako	194	19	capture	capture	VB
cord-007444-c9vu8ako	194	20	longer	long	JJR
cord-007444-c9vu8ako	194	21	-	-	HYPH
cord-007444-c9vu8ako	194	22	term	term	NN
cord-007444-c9vu8ako	194	23	benefits	benefit	NNS
cord-007444-c9vu8ako	194	24	of	of	IN
cord-007444-c9vu8ako	194	25	combination	combination	NN
cord-007444-c9vu8ako	194	26	therapy	therapy	NN
cord-007444-c9vu8ako	194	27	.	.	.
cord-007444-c9vu8ako	195	1	Comparing	compare	VBG
cord-007444-c9vu8ako	195	2	nebulized	nebulize	VBN
cord-007444-c9vu8ako	195	3	treatments	treatment	NNS
cord-007444-c9vu8ako	195	4	of	of	IN
cord-007444-c9vu8ako	195	5	salbutamol	salbutamol	NN
cord-007444-c9vu8ako	195	6	with	with	IN
cord-007444-c9vu8ako	195	7	and	and	CC
cord-007444-c9vu8ako	195	8	without	without	IN
cord-007444-c9vu8ako	195	9	IB	IB	NNP
cord-007444-c9vu8ako	195	10	among	among	IN
cord-007444-c9vu8ako	195	11	inpatients	inpatient	NNS
cord-007444-c9vu8ako	195	12	with	with	IN
cord-007444-c9vu8ako	195	13	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	195	14	,	,	,
cord-007444-c9vu8ako	195	15	they	-PRON-	PRP
cord-007444-c9vu8ako	195	16	found	find	VBD
cord-007444-c9vu8ako	195	17	no	no	DT
cord-007444-c9vu8ako	195	18	difference	difference	NN
cord-007444-c9vu8ako	195	19	in	in	IN
cord-007444-c9vu8ako	195	20	duration	duration	NN
cord-007444-c9vu8ako	195	21	of	of	IN
cord-007444-c9vu8ako	195	22	stay	stay	NN
cord-007444-c9vu8ako	195	23	,	,	,
cord-007444-c9vu8ako	195	24	subjective	subjective	JJ
cord-007444-c9vu8ako	195	25	breathlessness	breathlessness	NN
cord-007444-c9vu8ako	195	26	,	,	,
cord-007444-c9vu8ako	195	27	or	or	CC
cord-007444-c9vu8ako	195	28	spirometric	spirometric	JJ
cord-007444-c9vu8ako	195	29	values	value	NNS
cord-007444-c9vu8ako	195	30	over	over	IN
cord-007444-c9vu8ako	195	31	a	a	DT
cord-007444-c9vu8ako	195	32	14-day	14-day	CD
cord-007444-c9vu8ako	195	33	assessment	assessment	NN
cord-007444-c9vu8ako	195	34	period	period	NN
cord-007444-c9vu8ako	195	35	.	.	.
cord-007444-c9vu8ako	196	1	Considerable	considerable	JJ
cord-007444-c9vu8ako	196	2	effort	effort	NN
cord-007444-c9vu8ako	196	3	has	have	VBZ
cord-007444-c9vu8ako	196	4	been	be	VBN
cord-007444-c9vu8ako	196	5	made	make	VBN
cord-007444-c9vu8ako	196	6	to	to	TO
cord-007444-c9vu8ako	196	7	establish	establish	VB
cord-007444-c9vu8ako	196	8	the	the	DT
cord-007444-c9vu8ako	196	9	most	most	RBS
cord-007444-c9vu8ako	196	10	effective	effective	JJ
cord-007444-c9vu8ako	196	11	method	method	NN
cord-007444-c9vu8ako	196	12	for	for	IN
cord-007444-c9vu8ako	196	13	delivering	deliver	VBG
cord-007444-c9vu8ako	196	14	bronchodilator	bronchodilator	NN
cord-007444-c9vu8ako	196	15	drugs	drug	NNS
cord-007444-c9vu8ako	196	16	to	to	IN
cord-007444-c9vu8ako	196	17	patients	patient	NNS
cord-007444-c9vu8ako	196	18	with	with	IN
cord-007444-c9vu8ako	196	19	acute	acute	JJ
cord-007444-c9vu8ako	196	20	airflow	airflow	NN
cord-007444-c9vu8ako	196	21	obstruction	obstruction	NN
cord-007444-c9vu8ako	196	22	.	.	.
cord-007444-c9vu8ako	197	1	Delivery	delivery	NN
cord-007444-c9vu8ako	197	2	methods	method	NNS
cord-007444-c9vu8ako	197	3	include	include	VBP
cord-007444-c9vu8ako	197	4	MDIs	mdi	NNS
cord-007444-c9vu8ako	197	5	with	with	IN
cord-007444-c9vu8ako	197	6	or	or	CC
cord-007444-c9vu8ako	197	7	without	without	IN
cord-007444-c9vu8ako	197	8	a	a	DT
cord-007444-c9vu8ako	197	9	spacer	spacer	NN
cord-007444-c9vu8ako	197	10	device	device	NN
cord-007444-c9vu8ako	197	11	,	,	,
cord-007444-c9vu8ako	197	12	nebulizers	nebulizer	NNS
cord-007444-c9vu8ako	197	13	(	(	-LRB-
cord-007444-c9vu8ako	197	14	hand	hand	NN
cord-007444-c9vu8ako	197	15	-	-	HYPH
cord-007444-c9vu8ako	197	16	held	hold	VBN
cord-007444-c9vu8ako	197	17	or	or	CC
cord-007444-c9vu8ako	197	18	attached	attach	VBN
cord-007444-c9vu8ako	197	19	to	to	IN
cord-007444-c9vu8ako	197	20	a	a	DT
cord-007444-c9vu8ako	197	21	face	face	NN
cord-007444-c9vu8ako	197	22	mask	mask	NN
cord-007444-c9vu8ako	197	23	)	)	-RRB-
cord-007444-c9vu8ako	197	24	,	,	,
cord-007444-c9vu8ako	197	25	and	and	CC
cord-007444-c9vu8ako	197	26	dry	dry	JJ
cord-007444-c9vu8ako	197	27	powder	powder	NN
cord-007444-c9vu8ako	197	28	inhalers	inhaler	NNS
cord-007444-c9vu8ako	197	29	.	.	.
cord-007444-c9vu8ako	198	1	A	a	DT
cord-007444-c9vu8ako	198	2	recent	recent	JJ
cord-007444-c9vu8ako	198	3	systematic	systematic	JJ
cord-007444-c9vu8ako	198	4	review	review	NN
cord-007444-c9vu8ako	198	5	of	of	IN
cord-007444-c9vu8ako	198	6	12	12	CD
cord-007444-c9vu8ako	198	7	randomized	randomized	JJ
cord-007444-c9vu8ako	198	8	studies	study	NNS
cord-007444-c9vu8ako	198	9	comparing	compare	VBG
cord-007444-c9vu8ako	198	10	MDIs	mdi	NNS
cord-007444-c9vu8ako	198	11	and	and	CC
cord-007444-c9vu8ako	198	12	nebulizers	nebulizer	NNS
cord-007444-c9vu8ako	198	13	for	for	IN
cord-007444-c9vu8ako	198	14	administration	administration	NN
cord-007444-c9vu8ako	198	15	of	of	IN
cord-007444-c9vu8ako	198	16	p,-agonists	p,-agonists	NNPS
cord-007444-c9vu8ako	198	17	in	in	IN
cord-007444-c9vu8ako	198	18	acute	acute	JJ
cord-007444-c9vu8ako	198	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	198	20	of	of	IN
cord-007444-c9vu8ako	198	21	asthma	asthma	NN
cord-007444-c9vu8ako	198	22	and	and	CC
cord-007444-c9vu8ako	198	23	COPD	COPD	NNP
cord-007444-c9vu8ako	198	24	found	find	VBD
cord-007444-c9vu8ako	198	25	the	the	DT
cord-007444-c9vu8ako	198	26	two	two	CD
cord-007444-c9vu8ako	198	27	methods	method	NNS
cord-007444-c9vu8ako	198	28	to	to	TO
cord-007444-c9vu8ako	198	29	be	be	VB
cord-007444-c9vu8ako	198	30	equivalent.128	equivalent.128	NNP
cord-007444-c9vu8ako	199	1	A	a	DT
cord-007444-c9vu8ako	199	2	reasonable	reasonable	JJ
cord-007444-c9vu8ako	199	3	approach	approach	NN
cord-007444-c9vu8ako	199	4	advocated	advocate	VBN
cord-007444-c9vu8ako	199	5	by	by	IN
cord-007444-c9vu8ako	199	6	several	several	JJ
cord-007444-c9vu8ako	199	7	workers	worker	NNS
cord-007444-c9vu8ako	199	8	is	be	VBZ
cord-007444-c9vu8ako	199	9	to	to	TO
cord-007444-c9vu8ako	199	10	begin	begin	VB
cord-007444-c9vu8ako	199	11	with	with	IN
cord-007444-c9vu8ako	199	12	nebulized	nebulized	JJ
cord-007444-c9vu8ako	199	13	treatments	treatment	NNS
cord-007444-c9vu8ako	199	14	among	among	IN
cord-007444-c9vu8ako	199	15	patients	patient	NNS
cord-007444-c9vu8ako	199	16	who	who	WP
cord-007444-c9vu8ako	199	17	are	be	VBP
cord-007444-c9vu8ako	199	18	too	too	RB
cord-007444-c9vu8ako	199	19	dyspneic	dyspneic	JJ
cord-007444-c9vu8ako	199	20	to	to	TO
cord-007444-c9vu8ako	199	21	use	use	VB
cord-007444-c9vu8ako	199	22	an	an	DT
cord-007444-c9vu8ako	199	23	MDI	MDI	NNP
cord-007444-c9vu8ako	199	24	and	and	CC
cord-007444-c9vu8ako	199	25	spacer	spacer	NN
cord-007444-c9vu8ako	199	26	device	device	NN
cord-007444-c9vu8ako	200	1	~o	~o	NFP
cord-007444-c9vu8ako	201	1	r	r	NNP
cord-007444-c9vu8ako	201	2	r	r	NN
cord-007444-c9vu8ako	201	3	e	e	NN
cord-007444-c9vu8ako	201	4	c	c	NN
cord-007444-c9vu8ako	201	5	t	t	NNP
cord-007444-c9vu8ako	201	6	l	l	NNP
cord-007444-c9vu8ako	201	7	y	y	NNP
cord-007444-c9vu8ako	201	8	.~~,~~~	.~~,~~~	.
cord-007444-c9vu8ako	202	1	As	as	RB
cord-007444-c9vu8ako	202	2	early	early	RB
cord-007444-c9vu8ako	202	3	as	as	IN
cord-007444-c9vu8ako	202	4	is	be	VBZ
cord-007444-c9vu8ako	202	5	feasible	feasible	JJ
cord-007444-c9vu8ako	202	6	patients	patient	NNS
cord-007444-c9vu8ako	202	7	can	can	MD
cord-007444-c9vu8ako	202	8	then	then	RB
cord-007444-c9vu8ako	202	9	be	be	VB
cord-007444-c9vu8ako	202	10	switched	switch	VBN
cord-007444-c9vu8ako	202	11	to	to	IN
cord-007444-c9vu8ako	202	12	MDIs	mdi	NNS
cord-007444-c9vu8ako	202	13	,	,	,
cord-007444-c9vu8ako	202	14	which	which	WDT
cord-007444-c9vu8ako	202	15	can	can	MD
cord-007444-c9vu8ako	202	16	result	result	VB
cord-007444-c9vu8ako	202	17	in	in	IN
cord-007444-c9vu8ako	202	18	considerable	considerable	JJ
cord-007444-c9vu8ako	202	19	cost	cost	NN
cord-007444-c9vu8ako	202	20	savings.m	savings.m	NNS
cord-007444-c9vu8ako	202	21	,	,	,
cord-007444-c9vu8ako	202	22	lZo	lZo	''
cord-007444-c9vu8ako	202	23	Theophylline	theophylline	JJ
cord-007444-c9vu8ako	202	24	Theophylline	theophylline	NN
cord-007444-c9vu8ako	202	25	has	have	VBZ
cord-007444-c9vu8ako	202	26	been	be	VBN
cord-007444-c9vu8ako	202	27	used	use	VBN
cord-007444-c9vu8ako	202	28	for	for	IN
cord-007444-c9vu8ako	202	29	decades	decade	NNS
cord-007444-c9vu8ako	202	30	to	to	TO
cord-007444-c9vu8ako	202	31	ameliorate	ameliorate	VB
cord-007444-c9vu8ako	202	32	symptoms	symptom	NNS
cord-007444-c9vu8ako	202	33	in	in	IN
cord-007444-c9vu8ako	202	34	patients	patient	NNS
cord-007444-c9vu8ako	202	35	with	with	IN
cord-007444-c9vu8ako	202	36	airflow	airflow	NN
cord-007444-c9vu8ako	202	37	obstruction.lZ9	obstruction.lZ9	NNP
cord-007444-c9vu8ako	203	1	The	the	DT
cord-007444-c9vu8ako	203	2	use	use	NN
cord-007444-c9vu8ako	203	3	of	of	IN
cord-007444-c9vu8ako	203	4	theophylline	theophylline	NN
cord-007444-c9vu8ako	203	5	in	in	IN
cord-007444-c9vu8ako	203	6	the	the	DT
cord-007444-c9vu8ako	203	7	management	management	NN
cord-007444-c9vu8ako	203	8	of	of	IN
cord-007444-c9vu8ako	203	9	stable	stable	JJ
cord-007444-c9vu8ako	203	10	COPD	COPD	NNP
cord-007444-c9vu8ako	203	11	is	be	VBZ
cord-007444-c9vu8ako	203	12	discussed	discuss	VBN
cord-007444-c9vu8ako	203	13	in	in	IN
cord-007444-c9vu8ako	203	14	the	the	DT
cord-007444-c9vu8ako	203	15	article	article	NN
cord-007444-c9vu8ako	203	16	by	by	IN
cord-007444-c9vu8ako	203	17	Ferguson	Ferguson	NNP
cord-007444-c9vu8ako	203	18	in	in	IN
cord-007444-c9vu8ako	203	19	this	this	DT
cord-007444-c9vu8ako	203	20	issue	issue	NN
cord-007444-c9vu8ako	203	21	.	.	.
cord-007444-c9vu8ako	204	1	Theophylline	theophylline	NN
cord-007444-c9vu8ako	204	2	has	have	VBZ
cord-007444-c9vu8ako	204	3	now	now	RB
cord-007444-c9vu8ako	204	4	been	be	VBN
cord-007444-c9vu8ako	204	5	relegated	relegate	VBN
cord-007444-c9vu8ako	204	6	to	to	IN
cord-007444-c9vu8ako	204	7	having	have	VBG
cord-007444-c9vu8ako	204	8	a	a	DT
cord-007444-c9vu8ako	204	9	minor	minor	JJ
cord-007444-c9vu8ako	204	10	role	role	NN
cord-007444-c9vu8ako	204	11	in	in	IN
cord-007444-c9vu8ako	204	12	the	the	DT
cord-007444-c9vu8ako	204	13	acute	acute	JJ
cord-007444-c9vu8ako	204	14	setting	setting	NN
cord-007444-c9vu8ako	204	15	because	because	IN
cord-007444-c9vu8ako	204	16	of	of	IN
cord-007444-c9vu8ako	204	17	the	the	DT
cord-007444-c9vu8ako	204	18	development	development	NN
cord-007444-c9vu8ako	204	19	of	of	IN
cord-007444-c9vu8ako	204	20	safer	safe	JJR
cord-007444-c9vu8ako	204	21	and	and	CC
cord-007444-c9vu8ako	204	22	more	more	RBR
cord-007444-c9vu8ako	204	23	potent	potent	JJ
cord-007444-c9vu8ako	204	24	bronchodilators?l	bronchodilators?l	NNPS
cord-007444-c9vu8ako	204	25	,	,	,
cord-007444-c9vu8ako	204	26	74	74	CD
cord-007444-c9vu8ako	205	1	The	the	DT
cord-007444-c9vu8ako	205	2	lack	lack	NN
cord-007444-c9vu8ako	205	3	of	of	IN
cord-007444-c9vu8ako	205	4	convincing	convincing	JJ
cord-007444-c9vu8ako	205	5	,	,	,
cord-007444-c9vu8ako	205	6	well	well	RB
cord-007444-c9vu8ako	205	7	-	-	HYPH
cord-007444-c9vu8ako	205	8	designed	design	VBN
cord-007444-c9vu8ako	205	9	trials	trial	NNS
cord-007444-c9vu8ako	205	10	showing	show	VBG
cord-007444-c9vu8ako	205	11	its	-PRON-	PRP$
cord-007444-c9vu8ako	205	12	efficacy	efficacy	NN
cord-007444-c9vu8ako	205	13	has	have	VBZ
cord-007444-c9vu8ako	205	14	further	further	RB
cord-007444-c9vu8ako	205	15	contributed	contribute	VBN
cord-007444-c9vu8ako	205	16	to	to	IN
cord-007444-c9vu8ako	205	17	the	the	DT
cord-007444-c9vu8ako	205	18	decline	decline	NN
cord-007444-c9vu8ako	205	19	in	in	IN
cord-007444-c9vu8ako	205	20	its	-PRON-	PRP$
cord-007444-c9vu8ako	205	21	use.7o	use.7o	NNP
cord-007444-c9vu8ako	205	22	,	,	,
cord-007444-c9vu8ako	205	23	99	99	CD
cord-007444-c9vu8ako	205	24	,	,	,
cord-007444-c9vu8ako	205	25	137	137	CD
cord-007444-c9vu8ako	206	1	There	there	EX
cord-007444-c9vu8ako	206	2	are	be	VBP
cord-007444-c9vu8ako	206	3	only	only	RB
cord-007444-c9vu8ako	206	4	two	two	CD
cord-007444-c9vu8ako	206	5	published	publish	VBN
cord-007444-c9vu8ako	206	6	studies	study	NNS
cord-007444-c9vu8ako	206	7	that	that	WDT
cord-007444-c9vu8ako	206	8	relate	relate	VBP
cord-007444-c9vu8ako	206	9	specifically	specifically	RB
cord-007444-c9vu8ako	206	10	to	to	IN
cord-007444-c9vu8ako	206	11	the	the	DT
cord-007444-c9vu8ako	206	12	role	role	NN
cord-007444-c9vu8ako	206	13	of	of	IN
cord-007444-c9vu8ako	206	14	theophylline	theophylline	NN
cord-007444-c9vu8ako	206	15	in	in	IN
cord-007444-c9vu8ako	206	16	the	the	DT
cord-007444-c9vu8ako	206	17	treatment	treatment	NN
cord-007444-c9vu8ako	206	18	of	of	IN
cord-007444-c9vu8ako	206	19	COPD	COPD	NNP
cord-007444-c9vu8ako	206	20	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	206	21	.	.	.
cord-007444-c9vu8ako	207	1	The	the	DT
cord-007444-c9vu8ako	207	2	first	first	JJ
cord-007444-c9vu8ako	207	3	,	,	,
cord-007444-c9vu8ako	207	4	by	by	IN
cord-007444-c9vu8ako	207	5	Rice	Rice	NNP
cord-007444-c9vu8ako	207	6	et	et	NNP
cord-007444-c9vu8ako	208	1	al,99	al,99	LS
cord-007444-c9vu8ako	208	2	was	be	VBD
cord-007444-c9vu8ako	208	3	a	a	DT
cord-007444-c9vu8ako	208	4	small	small	JJ
cord-007444-c9vu8ako	208	5	,	,	,
cord-007444-c9vu8ako	208	6	yet	yet	CC
cord-007444-c9vu8ako	208	7	rigorously	rigorously	RB
cord-007444-c9vu8ako	208	8	controlled	control	VBN
cord-007444-c9vu8ako	208	9	trial	trial	NN
cord-007444-c9vu8ako	208	10	in	in	IN
cord-007444-c9vu8ako	208	11	which	which	WDT
cord-007444-c9vu8ako	208	12	patients	patient	NNS
cord-007444-c9vu8ako	208	13	were	be	VBD
cord-007444-c9vu8ako	208	14	randomized	randomize	VBN
cord-007444-c9vu8ako	208	15	to	to	IN
cord-007444-c9vu8ako	208	16	aminophylline	aminophylline	VB
cord-007444-c9vu8ako	208	17	infusion	infusion	NN
cord-007444-c9vu8ako	208	18	or	or	CC
cord-007444-c9vu8ako	208	19	placebo	placebo	NN
cord-007444-c9vu8ako	208	20	during	during	IN
cord-007444-c9vu8ako	208	21	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	208	22	for	for	IN
cord-007444-c9vu8ako	208	23	AE	AE	NNP
cord-007444-c9vu8ako	208	24	-	-	HYPH
cord-007444-c9vu8ako	208	25	COPD	COPD	NNP
cord-007444-c9vu8ako	208	26	.	.	.
cord-007444-c9vu8ako	209	1	The	the	DT
cord-007444-c9vu8ako	209	2	drug	drug	NN
cord-007444-c9vu8ako	209	3	conferred	confer	VBD
cord-007444-c9vu8ako	209	4	no	no	DT
cord-007444-c9vu8ako	209	5	incremental	incremental	JJ
cord-007444-c9vu8ako	209	6	benefit	benefit	NN
cord-007444-c9vu8ako	209	7	over	over	IN
cord-007444-c9vu8ako	209	8	standard	standard	JJ
cord-007444-c9vu8ako	209	9	care	care	NN
cord-007444-c9vu8ako	209	10	in	in	IN
cord-007444-c9vu8ako	209	11	either	either	CC
cord-007444-c9vu8ako	209	12	subjective	subjective	JJ
cord-007444-c9vu8ako	209	13	(	(	-LRB-
cord-007444-c9vu8ako	209	14	dyspnea	dyspnea	NN
cord-007444-c9vu8ako	209	15	scores	score	NNS
cord-007444-c9vu8ako	209	16	)	)	-RRB-
cord-007444-c9vu8ako	209	17	or	or	CC
cord-007444-c9vu8ako	209	18	objective	objective	JJ
cord-007444-c9vu8ako	209	19	(	(	-LRB-
cord-007444-c9vu8ako	209	20	spirometry	spirometry	NNP
cord-007444-c9vu8ako	209	21	)	)	-RRB-
cord-007444-c9vu8ako	209	22	outcome	outcome	NN
cord-007444-c9vu8ako	209	23	measures	measure	NNS
cord-007444-c9vu8ako	209	24	.	.	.
cord-007444-c9vu8ako	210	1	Gastrointestinal	gastrointestinal	JJ
cord-007444-c9vu8ako	210	2	side	side	NN
cord-007444-c9vu8ako	210	3	effects	effect	NNS
cord-007444-c9vu8ako	210	4	were	be	VBD
cord-007444-c9vu8ako	210	5	more	more	RBR
cord-007444-c9vu8ako	210	6	common	common	JJ
cord-007444-c9vu8ako	210	7	in	in	IN
cord-007444-c9vu8ako	210	8	the	the	DT
cord-007444-c9vu8ako	210	9	aminophylline	aminophylline	NN
cord-007444-c9vu8ako	210	10	group	group	NN
cord-007444-c9vu8ako	210	11	.	.	.
cord-007444-c9vu8ako	211	1	An	an	DT
cord-007444-c9vu8ako	211	2	emergency	emergency	NN
cord-007444-c9vu8ako	211	3	department	department	NN
cord-007444-c9vu8ako	211	4	-	-	HYPH
cord-007444-c9vu8ako	211	5	based	base	VBN
cord-007444-c9vu8ako	211	6	study	study	NN
cord-007444-c9vu8ako	211	7	randomized	randomize	VBD
cord-007444-c9vu8ako	211	8	patients	patient	NNS
cord-007444-c9vu8ako	211	9	with	with	IN
cord-007444-c9vu8ako	211	10	acute	acute	JJ
cord-007444-c9vu8ako	211	11	bronchospasm	bronchospasm	NN
cord-007444-c9vu8ako	211	12	to	to	TO
cord-007444-c9vu8ako	211	13	receive	receive	VB
cord-007444-c9vu8ako	211	14	either	either	CC
cord-007444-c9vu8ako	211	15	aminophylline	aminophylline	NN
cord-007444-c9vu8ako	211	16	or	or	CC
cord-007444-c9vu8ako	211	17	p1a	p1a	CD
cord-007444-c9vu8ako	212	1	~ebo.l~~	~ebo.l~~	NFP
cord-007444-c9vu8ako	212	2	The	the	DT
cord-007444-c9vu8ako	212	3	trial	trial	NN
cord-007444-c9vu8ako	212	4	included	include	VBD
cord-007444-c9vu8ako	212	5	patients	patient	NNS
cord-007444-c9vu8ako	212	6	with	with	IN
cord-007444-c9vu8ako	212	7	asthma	asthma	NN
cord-007444-c9vu8ako	212	8	and	and	CC
cord-007444-c9vu8ako	212	9	COPD	COPD	NNP
cord-007444-c9vu8ako	212	10	but	but	CC
cord-007444-c9vu8ako	212	11	failed	fail	VBD
cord-007444-c9vu8ako	212	12	to	to	TO
cord-007444-c9vu8ako	212	13	report	report	VB
cord-007444-c9vu8ako	212	14	the	the	DT
cord-007444-c9vu8ako	212	15	number	number	NN
cord-007444-c9vu8ako	212	16	of	of	IN
cord-007444-c9vu8ako	212	17	each	each	DT
cord-007444-c9vu8ako	212	18	.	.	.
cord-007444-c9vu8ako	213	1	Unexpectedly	unexpectedly	RB
cord-007444-c9vu8ako	213	2	,	,	,
cord-007444-c9vu8ako	213	3	there	there	EX
cord-007444-c9vu8ako	213	4	was	be	VBD
cord-007444-c9vu8ako	213	5	a	a	DT
cord-007444-c9vu8ako	213	6	threefold	threefold	JJ
cord-007444-c9vu8ako	213	7	decrease	decrease	NN
cord-007444-c9vu8ako	213	8	in	in	IN
cord-007444-c9vu8ako	213	9	the	the	DT
cord-007444-c9vu8ako	213	10	hospital	hospital	NN
cord-007444-c9vu8ako	213	11	admission	admission	NN
cord-007444-c9vu8ako	213	12	rate	rate	NN
cord-007444-c9vu8ako	213	13	for	for	IN
cord-007444-c9vu8ako	213	14	patients	patient	NNS
cord-007444-c9vu8ako	213	15	treated	treat	VBN
cord-007444-c9vu8ako	213	16	with	with	IN
cord-007444-c9vu8ako	213	17	aminophylline	aminophylline	NN
cord-007444-c9vu8ako	213	18	(	(	-LRB-
cord-007444-c9vu8ako	213	19	P	p	NN
cord-007444-c9vu8ako	213	20	=	=	SYM
cord-007444-c9vu8ako	213	21	0.016	0.016	CD
cord-007444-c9vu8ako	213	22	)	)	-RRB-
cord-007444-c9vu8ako	213	23	.	.	.
cord-007444-c9vu8ako	214	1	The	the	DT
cord-007444-c9vu8ako	214	2	authors	author	NNS
cord-007444-c9vu8ako	214	3	argued	argue	VBD
cord-007444-c9vu8ako	214	4	that	that	IN
cord-007444-c9vu8ako	214	5	aminophylline	aminophylline	NN
cord-007444-c9vu8ako	214	6	should	should	MD
cord-007444-c9vu8ako	214	7	be	be	VB
cord-007444-c9vu8ako	214	8	considered	consider	VBN
cord-007444-c9vu8ako	214	9	in	in	IN
cord-007444-c9vu8ako	214	10	selected	select	VBN
cord-007444-c9vu8ako	214	11	patients	patient	NNS
cord-007444-c9vu8ako	214	12	with	with	IN
cord-007444-c9vu8ako	214	13	acute	acute	JJ
cord-007444-c9vu8ako	214	14	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	214	15	of	of	IN
cord-007444-c9vu8ako	214	16	COPD	COPD	NNP
cord-007444-c9vu8ako	214	17	and	and	CC
cord-007444-c9vu8ako	214	18	asthma	asthma	NN
cord-007444-c9vu8ako	214	19	because	because	IN
cord-007444-c9vu8ako	214	20	reduced	reduce	VBN
cord-007444-c9vu8ako	214	21	hospitalizations	hospitalization	NNS
cord-007444-c9vu8ako	214	22	would	would	MD
cord-007444-c9vu8ako	214	23	decrease	decrease	VB
cord-007444-c9vu8ako	214	24	costs	cost	NNS
cord-007444-c9vu8ako	214	25	.	.	.
cord-007444-c9vu8ako	215	1	Although	although	IN
cord-007444-c9vu8ako	215	2	their	-PRON-	PRP$
cord-007444-c9vu8ako	215	3	study	study	NN
cord-007444-c9vu8ako	215	4	illustrates	illustrate	VBZ
cord-007444-c9vu8ako	215	5	a	a	DT
cord-007444-c9vu8ako	215	6	potentially	potentially	RB
cord-007444-c9vu8ako	215	7	important	important	JJ
cord-007444-c9vu8ako	215	8	clinical	clinical	JJ
cord-007444-c9vu8ako	215	9	benefit	benefit	NN
cord-007444-c9vu8ako	215	10	of	of	IN
cord-007444-c9vu8ako	215	11	theophylline	theophylline	NN
cord-007444-c9vu8ako	215	12	,	,	,
cord-007444-c9vu8ako	215	13	a	a	DT
cord-007444-c9vu8ako	215	14	cautious	cautious	JJ
cord-007444-c9vu8ako	215	15	approach	approach	NN
cord-007444-c9vu8ako	215	16	is	be	VBZ
cord-007444-c9vu8ako	215	17	necessary	necessary	JJ
cord-007444-c9vu8ako	215	18	.	.	.
cord-007444-c9vu8ako	216	1	The	the	DT
cord-007444-c9vu8ako	216	2	effect	effect	NN
cord-007444-c9vu8ako	216	3	of	of	IN
cord-007444-c9vu8ako	216	4	theophylline	theophylline	NN
cord-007444-c9vu8ako	216	5	on	on	IN
cord-007444-c9vu8ako	216	6	admission	admission	NN
cord-007444-c9vu8ako	216	7	rates	rate	NNS
cord-007444-c9vu8ako	216	8	was	be	VBD
cord-007444-c9vu8ako	216	9	not	not	RB
cord-007444-c9vu8ako	216	10	the	the	DT
cord-007444-c9vu8ako	216	11	primary	primary	JJ
cord-007444-c9vu8ako	216	12	outcome	outcome	NN
cord-007444-c9vu8ako	216	13	variable	variable	NN
cord-007444-c9vu8ako	216	14	and	and	CC
cord-007444-c9vu8ako	216	15	the	the	DT
cord-007444-c9vu8ako	216	16	reduction	reduction	NN
cord-007444-c9vu8ako	216	17	in	in	IN
cord-007444-c9vu8ako	216	18	admission	admission	NN
cord-007444-c9vu8ako	216	19	rates	rate	NNS
cord-007444-c9vu8ako	216	20	did	do	VBD
cord-007444-c9vu8ako	216	21	not	not	RB
cord-007444-c9vu8ako	216	22	quite	quite	RB
cord-007444-c9vu8ako	216	23	reach	reach	VB
cord-007444-c9vu8ako	216	24	statistical	statistical	JJ
cord-007444-c9vu8ako	216	25	significance	significance	NN
cord-007444-c9vu8ako	216	26	after	after	IN
cord-007444-c9vu8ako	216	27	adjusting	adjust	VBG
cord-007444-c9vu8ako	216	28	for	for	IN
cord-007444-c9vu8ako	216	29	multiple	multiple	JJ
cord-007444-c9vu8ako	216	30	comparisons	comparison	NNS
cord-007444-c9vu8ako	216	31	.	.	.
cord-007444-c9vu8ako	217	1	Even	even	RB
cord-007444-c9vu8ako	217	2	though	though	IN
cord-007444-c9vu8ako	217	3	the	the	DT
cord-007444-c9vu8ako	217	4	magnitude	magnitude	NN
cord-007444-c9vu8ako	217	5	of	of	IN
cord-007444-c9vu8ako	217	6	the	the	DT
cord-007444-c9vu8ako	217	7	clinical	clinical	JJ
cord-007444-c9vu8ako	217	8	benefit	benefit	NN
cord-007444-c9vu8ako	217	9	was	be	VBD
cord-007444-c9vu8ako	217	10	large	large	JJ
cord-007444-c9vu8ako	217	11	,	,	,
cord-007444-c9vu8ako	217	12	theophylline	theophylline	NN
cord-007444-c9vu8ako	217	13	produced	produce	VBD
cord-007444-c9vu8ako	217	14	no	no	DT
cord-007444-c9vu8ako	217	15	objective	objective	JJ
cord-007444-c9vu8ako	217	16	improvement	improvement	NN
cord-007444-c9vu8ako	217	17	in	in	IN
cord-007444-c9vu8ako	217	18	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	217	19	function	function	NN
cord-007444-c9vu8ako	217	20	as	as	IN
cord-007444-c9vu8ako	217	21	measured	measure	VBN
cord-007444-c9vu8ako	217	22	by	by	IN
cord-007444-c9vu8ako	217	23	spirometry	spirometry	NNP
cord-007444-c9vu8ako	217	24	.	.	.
cord-007444-c9vu8ako	218	1	Despite	despite	IN
cord-007444-c9vu8ako	218	2	these	these	DT
cord-007444-c9vu8ako	218	3	reservations	reservation	NNS
cord-007444-c9vu8ako	218	4	,	,	,
cord-007444-c9vu8ako	218	5	similar	similar	JJ
cord-007444-c9vu8ako	218	6	reports	report	NNS
cord-007444-c9vu8ako	218	7	of	of	IN
cord-007444-c9vu8ako	218	8	clinical	clinical	JJ
cord-007444-c9vu8ako	218	9	benefit	benefit	NN
cord-007444-c9vu8ako	218	10	in	in	IN
cord-007444-c9vu8ako	218	11	the	the	DT
cord-007444-c9vu8ako	218	12	absence	absence	NN
cord-007444-c9vu8ako	218	13	of	of	IN
cord-007444-c9vu8ako	218	14	statistically	statistically	RB
cord-007444-c9vu8ako	218	15	significant	significant	JJ
cord-007444-c9vu8ako	218	16	spirometric	spirometric	JJ
cord-007444-c9vu8ako	218	17	improvement	improvement	NN
cord-007444-c9vu8ako	218	18	have	have	VBP
cord-007444-c9vu8ako	218	19	been	be	VBN
cord-007444-c9vu8ako	218	20	found	find	VBN
cord-007444-c9vu8ako	218	21	in	in	IN
cord-007444-c9vu8ako	218	22	studies	study	NNS
cord-007444-c9vu8ako	218	23	of	of	IN
cord-007444-c9vu8ako	218	24	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	218	25	in	in	IN
cord-007444-c9vu8ako	218	26	acute	acute	NN
cord-007444-c9vu8ako	218	27	asthma71	asthma71	NNS
cord-007444-c9vu8ako	218	28	and	and	CC
cord-007444-c9vu8ako	218	29	bronchodilator	bronchodilator	NN
cord-007444-c9vu8ako	218	30	therapy	therapy	NN
cord-007444-c9vu8ako	218	31	in	in	IN
cord-007444-c9vu8ako	218	32	acute	acute	JJ
cord-007444-c9vu8ako	218	33	COPD.ll0	COPD.ll0	NNP
cord-007444-c9vu8ako	218	34	Bacterial	bacterial	JJ
cord-007444-c9vu8ako	218	35	infections	infection	NNS
cord-007444-c9vu8ako	218	36	'	'	POS
cord-007444-c9vu8ako	218	37	contribution	contribution	NN
cord-007444-c9vu8ako	218	38	to	to	IN
cord-007444-c9vu8ako	218	39	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	218	40	of	of	IN
cord-007444-c9vu8ako	218	41	COPD	COPD	NNP
cord-007444-c9vu8ako	218	42	has	have	VBZ
cord-007444-c9vu8ako	218	43	been	be	VBN
cord-007444-c9vu8ako	218	44	inferred	infer	VBN
cord-007444-c9vu8ako	218	45	from	from	IN
cord-007444-c9vu8ako	218	46	studies	study	NNS
cord-007444-c9vu8ako	218	47	demonstrating	demonstrate	VBG
cord-007444-c9vu8ako	218	48	clinical	clinical	JJ
cord-007444-c9vu8ako	218	49	benefit	benefit	NN
cord-007444-c9vu8ako	218	50	as	as	IN
cord-007444-c9vu8ako	218	51	a	a	DT
cord-007444-c9vu8ako	218	52	result	result	NN
cord-007444-c9vu8ako	218	53	of	of	IN
cord-007444-c9vu8ako	218	54	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	218	55	therapy	therapy	NN
cord-007444-c9vu8ako	218	56	.	.	.
cord-007444-c9vu8ako	219	1	Antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	219	2	have	have	VBP
cord-007444-c9vu8ako	219	3	been	be	VBN
cord-007444-c9vu8ako	219	4	employed	employ	VBN
cord-007444-c9vu8ako	219	5	for	for	IN
cord-007444-c9vu8ako	219	6	prophylaxis	prophylaxis	NN
cord-007444-c9vu8ako	219	7	and	and	CC
cord-007444-c9vu8ako	219	8	acute	acute	JJ
cord-007444-c9vu8ako	219	9	treatment	treatment	NN
cord-007444-c9vu8ako	219	10	of	of	IN
cord-007444-c9vu8ako	219	11	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	219	12	.	.	.
cord-007444-c9vu8ako	220	1	In	in	IN
cord-007444-c9vu8ako	220	2	the	the	DT
cord-007444-c9vu8ako	220	3	1950s	1950	NNS
cord-007444-c9vu8ako	220	4	and	and	CC
cord-007444-c9vu8ako	220	5	1960s	1960	NNS
cord-007444-c9vu8ako	220	6	,	,	,
cord-007444-c9vu8ako	220	7	attention	attention	NN
cord-007444-c9vu8ako	220	8	was	be	VBD
cord-007444-c9vu8ako	220	9	given	give	VBN
cord-007444-c9vu8ako	220	10	to	to	IN
cord-007444-c9vu8ako	220	11	preventing	prevent	VBG
cord-007444-c9vu8ako	220	12	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	220	13	with	with	IN
cord-007444-c9vu8ako	220	14	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	220	15	.	.	.
cord-007444-c9vu8ako	221	1	Murphy	Murphy	NNP
cord-007444-c9vu8ako	221	2	and	and	CC
cord-007444-c9vu8ako	221	3	Sethim	Sethim	NNP
cord-007444-c9vu8ako	221	4	reviewed	review	VBD
cord-007444-c9vu8ako	221	5	nine	nine	CD
cord-007444-c9vu8ako	221	6	prospective	prospective	JJ
cord-007444-c9vu8ako	221	7	,	,	,
cord-007444-c9vu8ako	221	8	placebocontrolled	placebocontrolled	JJ
cord-007444-c9vu8ako	221	9	trials	trial	NNS
cord-007444-c9vu8ako	221	10	of	of	IN
cord-007444-c9vu8ako	221	11	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	221	12	prophylaxis	prophylaxis	NN
cord-007444-c9vu8ako	221	13	.	.	.
cord-007444-c9vu8ako	222	1	Of	of	IN
cord-007444-c9vu8ako	222	2	these	these	DT
cord-007444-c9vu8ako	222	3	,	,	,
cord-007444-c9vu8ako	222	4	five	five	CD
cord-007444-c9vu8ako	222	5	failed	fail	VBD
cord-007444-c9vu8ako	222	6	to	to	TO
cord-007444-c9vu8ako	222	7	show	show	VB
cord-007444-c9vu8ako	222	8	any	any	DT
cord-007444-c9vu8ako	222	9	reduction	reduction	NN
cord-007444-c9vu8ako	222	10	in	in	IN
cord-007444-c9vu8ako	222	11	the	the	DT
cord-007444-c9vu8ako	222	12	frequency	frequency	NN
cord-007444-c9vu8ako	222	13	of	of	IN
cord-007444-c9vu8ako	222	14	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	222	15	,	,	,
cord-007444-c9vu8ako	222	16	although	although	IN
cord-007444-c9vu8ako	222	17	two	two	CD
cord-007444-c9vu8ako	222	18	demonstrated	demonstrate	VBD
cord-007444-c9vu8ako	222	19	significantly	significantly	RB
cord-007444-c9vu8ako	222	20	less	less	JJR
cord-007444-c9vu8ako	222	21	time	time	NN
cord-007444-c9vu8ako	222	22	lost	lose	VBN
cord-007444-c9vu8ako	222	23	from	from	IN
cord-007444-c9vu8ako	222	24	work	work	NN
cord-007444-c9vu8ako	222	25	among	among	IN
cord-007444-c9vu8ako	222	26	patients	patient	NNS
cord-007444-c9vu8ako	222	27	receiving	receive	VBG
cord-007444-c9vu8ako	222	28	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	222	29	.	.	.
cord-007444-c9vu8ako	223	1	In	in	IN
cord-007444-c9vu8ako	223	2	contrast	contrast	NN
cord-007444-c9vu8ako	223	3	,	,	,
cord-007444-c9vu8ako	223	4	compared	compare	VBN
cord-007444-c9vu8ako	223	5	with	with	IN
cord-007444-c9vu8ako	223	6	placebo	placebo	NN
cord-007444-c9vu8ako	223	7	,	,	,
cord-007444-c9vu8ako	223	8	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	223	9	prophylaxis	prophylaxis	NN
cord-007444-c9vu8ako	223	10	significantly	significantly	RB
cord-007444-c9vu8ako	223	11	reduced	reduce	VBD
cord-007444-c9vu8ako	223	12	the	the	DT
cord-007444-c9vu8ako	223	13	frequency	frequency	NN
cord-007444-c9vu8ako	223	14	of	of	IN
cord-007444-c9vu8ako	223	15	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	223	16	in	in	IN
cord-007444-c9vu8ako	223	17	four	four	CD
cord-007444-c9vu8ako	223	18	studies	study	NNS
cord-007444-c9vu8ako	223	19	.	.	.
cord-007444-c9vu8ako	224	1	In	in	IN
cord-007444-c9vu8ako	224	2	these	these	DT
cord-007444-c9vu8ako	224	3	investigations	investigation	NNS
cord-007444-c9vu8ako	224	4	,	,	,
cord-007444-c9vu8ako	224	5	prophylaxis	prophylaxis	NN
cord-007444-c9vu8ako	224	6	seemed	seem	VBD
cord-007444-c9vu8ako	224	7	to	to	TO
cord-007444-c9vu8ako	224	8	benefit	benefit	VB
cord-007444-c9vu8ako	224	9	patients	patient	NNS
cord-007444-c9vu8ako	224	10	suffering	suffer	VBG
cord-007444-c9vu8ako	224	11	the	the	DT
cord-007444-c9vu8ako	224	12	largest	large	JJS
cord-007444-c9vu8ako	224	13	annual	annual	JJ
cord-007444-c9vu8ako	224	14	number	number	NN
cord-007444-c9vu8ako	224	15	of	of	IN
cord-007444-c9vu8ako	224	16	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	224	17	.	.	.
cord-007444-c9vu8ako	225	1	Some	some	DT
cord-007444-c9vu8ako	225	2	authorities	authority	NNS
cord-007444-c9vu8ako	225	3	therefore	therefore	RB
cord-007444-c9vu8ako	225	4	have	have	VBP
cord-007444-c9vu8ako	225	5	recently	recently	RB
cord-007444-c9vu8ako	225	6	suggested	suggest	VBN
cord-007444-c9vu8ako	225	7	that	that	IN
cord-007444-c9vu8ako	225	8	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	225	9	prophylaxis	prophylaxis	NN
cord-007444-c9vu8ako	225	10	may	may	MD
cord-007444-c9vu8ako	225	11	be	be	VB
cord-007444-c9vu8ako	225	12	appropriate	appropriate	JJ
cord-007444-c9vu8ako	225	13	for	for	IN
cord-007444-c9vu8ako	225	14	individuals	individual	NNS
cord-007444-c9vu8ako	225	15	prone	prone	JJ
cord-007444-c9vu8ako	225	16	to	to	IN
cord-007444-c9vu8ako	225	17	frequent	frequent	JJ
cord-007444-c9vu8ako	225	18	exacerbation^,'^	exacerbation^,'^	NNS
cord-007444-c9vu8ako	225	19	although	although	IN
cord-007444-c9vu8ako	225	20	this	this	DT
cord-007444-c9vu8ako	225	21	practice	practice	NN
cord-007444-c9vu8ako	225	22	is	be	VBZ
cord-007444-c9vu8ako	225	23	not	not	RB
cord-007444-c9vu8ako	225	24	recommended	recommend	VBN
cord-007444-c9vu8ako	225	25	as	as	IN
cord-007444-c9vu8ako	225	26	part	part	NN
cord-007444-c9vu8ako	225	27	of	of	IN
cord-007444-c9vu8ako	225	28	the	the	DT
cord-007444-c9vu8ako	225	29	regular	regular	JJ
cord-007444-c9vu8ako	225	30	care	care	NN
cord-007444-c9vu8ako	225	31	of	of	IN
cord-007444-c9vu8ako	225	32	all	all	DT
cord-007444-c9vu8ako	225	33	patients	patient	NNS
cord-007444-c9vu8ako	225	34	with	with	IN
cord-007444-c9vu8ako	225	35	COPD	COPD	NNP
cord-007444-c9vu8ako	225	36	.	.	.
cord-007444-c9vu8ako	226	1	The	the	DT
cord-007444-c9vu8ako	226	2	prescription	prescription	NN
cord-007444-c9vu8ako	226	3	of	of	IN
cord-007444-c9vu8ako	226	4	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	226	5	to	to	TO
cord-007444-c9vu8ako	226	6	facilitate	facilitate	VB
cord-007444-c9vu8ako	226	7	early	early	JJ
cord-007444-c9vu8ako	226	8	recovery	recovery	NN
cord-007444-c9vu8ako	226	9	in	in	IN
cord-007444-c9vu8ako	226	10	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	226	11	has	have	VBZ
cord-007444-c9vu8ako	226	12	become	become	VBN
cord-007444-c9vu8ako	226	13	routine	routine	JJ
cord-007444-c9vu8ako	226	14	despite	despite	IN
cord-007444-c9vu8ako	226	15	unresolved	unresolved	JJ
cord-007444-c9vu8ako	226	16	questions	question	NNS
cord-007444-c9vu8ako	226	17	about	about	IN
cord-007444-c9vu8ako	226	18	their	-PRON-	PRP$
cord-007444-c9vu8ako	226	19	true	true	JJ
cord-007444-c9vu8ako	226	20	benefit	benefit	NN
cord-007444-c9vu8ako	226	21	.	.	.
cord-007444-c9vu8ako	226	22	'	'	''
cord-007444-c9vu8ako	227	1	"	"	``
cord-007444-c9vu8ako	227	2	51	51	CD
cord-007444-c9vu8ako	227	3	,	,	,
cord-007444-c9vu8ako	227	4	52	52	CD
cord-007444-c9vu8ako	227	5	,	,	,
cord-007444-c9vu8ako	227	6	83	83	CD
cord-007444-c9vu8ako	227	7	Nicotra	Nicotra	NNP
cord-007444-c9vu8ako	227	8	et	et	NNP
cord-007444-c9vu8ako	227	9	aP7	ap7	NN
cord-007444-c9vu8ako	228	1	randomized	randomized	JJ
cord-007444-c9vu8ako	228	2	40	40	CD
cord-007444-c9vu8ako	228	3	inpatients	inpatient	NNS
cord-007444-c9vu8ako	228	4	with	with	IN
cord-007444-c9vu8ako	228	5	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	228	6	to	to	IN
cord-007444-c9vu8ako	228	7	either	either	CC
cord-007444-c9vu8ako	228	8	tetracycline	tetracycline	NN
cord-007444-c9vu8ako	228	9	or	or	CC
cord-007444-c9vu8ako	228	10	placebo	placebo	NN
cord-007444-c9vu8ako	228	11	for	for	IN
cord-007444-c9vu8ako	228	12	1	1	CD
cord-007444-c9vu8ako	228	13	week	week	NN
cord-007444-c9vu8ako	228	14	.	.	.
cord-007444-c9vu8ako	229	1	At	at	IN
cord-007444-c9vu8ako	229	2	7	7	CD
cord-007444-c9vu8ako	229	3	days	day	NNS
cord-007444-c9vu8ako	229	4	,	,	,
cord-007444-c9vu8ako	229	5	there	there	EX
cord-007444-c9vu8ako	229	6	was	be	VBD
cord-007444-c9vu8ako	229	7	no	no	DT
cord-007444-c9vu8ako	229	8	difference	difference	NN
cord-007444-c9vu8ako	229	9	between	between	IN
cord-007444-c9vu8ako	229	10	groups	group	NNS
cord-007444-c9vu8ako	229	11	in	in	IN
cord-007444-c9vu8ako	229	12	terms	term	NNS
cord-007444-c9vu8ako	229	13	of	of	IN
cord-007444-c9vu8ako	229	14	oxygenation	oxygenation	NN
cord-007444-c9vu8ako	229	15	or	or	CC
cord-007444-c9vu8ako	229	16	lung	lung	NN
cord-007444-c9vu8ako	229	17	function	function	NN
cord-007444-c9vu8ako	229	18	.	.	.
cord-007444-c9vu8ako	230	1	In	in	IN
cord-007444-c9vu8ako	230	2	a	a	DT
cord-007444-c9vu8ako	230	3	similar	similar	JJ
cord-007444-c9vu8ako	230	4	,	,	,
cord-007444-c9vu8ako	230	5	but	but	CC
cord-007444-c9vu8ako	230	6	larger	large	JJR
cord-007444-c9vu8ako	230	7	,	,	,
cord-007444-c9vu8ako	230	8	study	study	NN
cord-007444-c9vu8ako	230	9	of	of	IN
cord-007444-c9vu8ako	230	10	outpatients	outpatient	NNS
cord-007444-c9vu8ako	230	11	with	with	IN
cord-007444-c9vu8ako	230	12	uncomplicated	uncomplicated	JJ
cord-007444-c9vu8ako	230	13	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	230	14	,	,	,
cord-007444-c9vu8ako	230	15	Jorgensedl	Jorgensedl	NNP
cord-007444-c9vu8ako	230	16	also	also	RB
cord-007444-c9vu8ako	230	17	could	could	MD
cord-007444-c9vu8ako	230	18	not	not	RB
cord-007444-c9vu8ako	230	19	demonstrate	demonstrate	VB
cord-007444-c9vu8ako	230	20	a	a	DT
cord-007444-c9vu8ako	230	21	clinically	clinically	RB
cord-007444-c9vu8ako	230	22	important	important	JJ
cord-007444-c9vu8ako	230	23	advantage	advantage	NN
cord-007444-c9vu8ako	230	24	of	of	IN
cord-007444-c9vu8ako	230	25	amoxicillin	amoxicillin	NNP
cord-007444-c9vu8ako	230	26	over	over	IN
cord-007444-c9vu8ako	230	27	placebo	placebo	NN
cord-007444-c9vu8ako	230	28	.	.	.
cord-007444-c9vu8ako	231	1	These	these	DT
cord-007444-c9vu8ako	231	2	null	null	JJ
cord-007444-c9vu8ako	231	3	trials	trial	NNS
cord-007444-c9vu8ako	231	4	notwithstanding	notwithstanding	RB
cord-007444-c9vu8ako	232	1	,	,	,
cord-007444-c9vu8ako	232	2	the	the	DT
cord-007444-c9vu8ako	232	3	highestquality	highestquality	NNP
cord-007444-c9vu8ako	232	4	clinical	clinical	JJ
cord-007444-c9vu8ako	232	5	study	study	NN
cord-007444-c9vu8ako	232	6	to	to	IN
cord-007444-c9vu8ako	232	7	date	date	NN
cord-007444-c9vu8ako	232	8	,	,	,
cord-007444-c9vu8ako	232	9	by	by	IN
cord-007444-c9vu8ako	232	10	Anthonisen	Anthonisen	NNP
cord-007444-c9vu8ako	232	11	et	et	NNP
cord-007444-c9vu8ako	232	12	al	al	NNP
cord-007444-c9vu8ako	232	13	,	,	,
cord-007444-c9vu8ako	232	14	"	"	''
cord-007444-c9vu8ako	232	15	concluded	conclude	VBD
cord-007444-c9vu8ako	232	16	that	that	IN
cord-007444-c9vu8ako	232	17	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	232	18	improved	improve	VBD
cord-007444-c9vu8ako	232	19	outcomes	outcome	NNS
cord-007444-c9vu8ako	232	20	.	.	.
cord-007444-c9vu8ako	233	1	They	-PRON-	PRP
cord-007444-c9vu8ako	233	2	randomized	randomize	VBD
cord-007444-c9vu8ako	233	3	173	173	CD
cord-007444-c9vu8ako	233	4	outpatients	outpatient	NNS
cord-007444-c9vu8ako	233	5	to	to	TO
cord-007444-c9vu8ako	233	6	receive	receive	VB
cord-007444-c9vu8ako	233	7	either	either	CC
cord-007444-c9vu8ako	233	8	placebo	placebo	NN
cord-007444-c9vu8ako	233	9	or	or	CC
cord-007444-c9vu8ako	233	10	broad	broad	JJ
cord-007444-c9vu8ako	233	11	-	-	HYPH
cord-007444-c9vu8ako	233	12	spectrum	spectrum	NN
cord-007444-c9vu8ako	233	13	antibiotic	antibiotic	NN
cord-007444-c9vu8ako	233	14	(	(	-LRB-
cord-007444-c9vu8ako	233	15	amoxicillin	amoxicillin	NNP
cord-007444-c9vu8ako	233	16	,	,	,
cord-007444-c9vu8ako	233	17	trimethoprim	trimethoprim	NNP
cord-007444-c9vu8ako	233	18	-	-	HYPH
cord-007444-c9vu8ako	233	19	sulfamethoxazole	sulfamethoxazole	NNP
cord-007444-c9vu8ako	233	20	,	,	,
cord-007444-c9vu8ako	233	21	or	or	CC
cord-007444-c9vu8ako	233	22	doxycycline	doxycycline	NNP
cord-007444-c9vu8ako	233	23	)	)	-RRB-
cord-007444-c9vu8ako	233	24	during	during	IN
cord-007444-c9vu8ako	233	25	362	362	CD
cord-007444-c9vu8ako	233	26	COPD	COPD	NNP
cord-007444-c9vu8ako	233	27	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	233	28	.	.	.
cord-007444-c9vu8ako	234	1	Exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	234	2	were	be	VBD
cord-007444-c9vu8ako	234	3	classified	classify	VBN
cord-007444-c9vu8ako	234	4	according	accord	VBG
cord-007444-c9vu8ako	234	5	to	to	IN
cord-007444-c9vu8ako	234	6	severity	severity	NN
cord-007444-c9vu8ako	234	7	.	.	.
cord-007444-c9vu8ako	235	1	Type	type	NN
cord-007444-c9vu8ako	235	2	1	1	CD
cord-007444-c9vu8ako	235	3	(	(	-LRB-
cord-007444-c9vu8ako	235	4	the	the	DT
cord-007444-c9vu8ako	235	5	most	most	RBS
cord-007444-c9vu8ako	235	6	severe	severe	JJ
cord-007444-c9vu8ako	235	7	)	)	-RRB-
cord-007444-c9vu8ako	235	8	was	be	VBD
cord-007444-c9vu8ako	235	9	defined	define	VBN
cord-007444-c9vu8ako	235	10	as	as	IN
cord-007444-c9vu8ako	235	11	an	an	DT
cord-007444-c9vu8ako	235	12	increase	increase	NN
cord-007444-c9vu8ako	235	13	in	in	IN
cord-007444-c9vu8ako	235	14	dyspnea	dyspnea	NN
cord-007444-c9vu8ako	235	15	,	,	,
cord-007444-c9vu8ako	235	16	sputum	sputum	NN
cord-007444-c9vu8ako	235	17	volume	volume	NN
cord-007444-c9vu8ako	235	18	,	,	,
cord-007444-c9vu8ako	235	19	and	and	CC
cord-007444-c9vu8ako	235	20	sputum	sputum	NN
cord-007444-c9vu8ako	235	21	purulence	purulence	NN
cord-007444-c9vu8ako	235	22	.	.	.
cord-007444-c9vu8ako	236	1	Type	type	NN
cord-007444-c9vu8ako	236	2	2	2	CD
cord-007444-c9vu8ako	236	3	involved	involve	VBD
cord-007444-c9vu8ako	236	4	the	the	DT
cord-007444-c9vu8ako	236	5	presence	presence	NN
cord-007444-c9vu8ako	236	6	of	of	IN
cord-007444-c9vu8ako	236	7	only	only	RB
cord-007444-c9vu8ako	236	8	two	two	CD
cord-007444-c9vu8ako	236	9	of	of	IN
cord-007444-c9vu8ako	236	10	the	the	DT
cord-007444-c9vu8ako	236	11	three	three	CD
cord-007444-c9vu8ako	236	12	symptoms	symptom	NNS
cord-007444-c9vu8ako	236	13	,	,	,
cord-007444-c9vu8ako	236	14	and	and	CC
cord-007444-c9vu8ako	236	15	type	type	NN
cord-007444-c9vu8ako	236	16	3	3	CD
cord-007444-c9vu8ako	236	17	was	be	VBD
cord-007444-c9vu8ako	236	18	defined	define	VBN
cord-007444-c9vu8ako	236	19	as	as	IN
cord-007444-c9vu8ako	236	20	the	the	DT
cord-007444-c9vu8ako	236	21	presence	presence	NN
cord-007444-c9vu8ako	236	22	of	of	IN
cord-007444-c9vu8ako	236	23	one	one	CD
cord-007444-c9vu8ako	236	24	of	of	IN
cord-007444-c9vu8ako	236	25	the	the	DT
cord-007444-c9vu8ako	236	26	three	three	CD
cord-007444-c9vu8ako	236	27	symptoms	symptom	NNS
cord-007444-c9vu8ako	236	28	in	in	IN
cord-007444-c9vu8ako	236	29	addition	addition	NN
cord-007444-c9vu8ako	236	30	to	to	IN
cord-007444-c9vu8ako	236	31	one	one	CD
cord-007444-c9vu8ako	236	32	other	other	JJ
cord-007444-c9vu8ako	236	33	finding	finding	NN
cord-007444-c9vu8ako	236	34	(	(	-LRB-
cord-007444-c9vu8ako	236	35	sore	sore	JJ
cord-007444-c9vu8ako	236	36	throat	throat	NN
cord-007444-c9vu8ako	236	37	,	,	,
cord-007444-c9vu8ako	236	38	rhinorrhea	rhinorrhea	NN
cord-007444-c9vu8ako	236	39	,	,	,
cord-007444-c9vu8ako	236	40	fever	fever	NN
cord-007444-c9vu8ako	236	41	,	,	,
cord-007444-c9vu8ako	236	42	increased	increase	VBN
cord-007444-c9vu8ako	236	43	wheeze	wheeze	NN
cord-007444-c9vu8ako	236	44	,	,	,
cord-007444-c9vu8ako	236	45	or	or	CC
cord-007444-c9vu8ako	236	46	increased	increase	VBN
cord-007444-c9vu8ako	236	47	cough	cough	NN
cord-007444-c9vu8ako	236	48	)	)	-RRB-
cord-007444-c9vu8ako	236	49	.	.	.
cord-007444-c9vu8ako	237	1	Compared	compare	VBN
cord-007444-c9vu8ako	237	2	with	with	IN
cord-007444-c9vu8ako	237	3	placebo	placebo	NN
cord-007444-c9vu8ako	237	4	,	,	,
cord-007444-c9vu8ako	237	5	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	237	6	shortened	shorten	VBD
cord-007444-c9vu8ako	237	7	the	the	DT
cord-007444-c9vu8ako	237	8	duration	duration	NN
cord-007444-c9vu8ako	237	9	of	of	IN
cord-007444-c9vu8ako	237	10	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	237	11	by	by	IN
cord-007444-c9vu8ako	237	12	about	about	RB
cord-007444-c9vu8ako	237	13	2	2	CD
cord-007444-c9vu8ako	237	14	days	day	NNS
cord-007444-c9vu8ako	237	15	and	and	CC
cord-007444-c9vu8ako	237	16	accelerated	accelerated	JJ
cord-007444-c9vu8ako	237	17	recovery	recovery	NN
cord-007444-c9vu8ako	237	18	of	of	IN
cord-007444-c9vu8ako	237	19	peak	peak	NN
cord-007444-c9vu8ako	237	20	expiratory	expiratory	JJ
cord-007444-c9vu8ako	237	21	flow	flow	NN
cord-007444-c9vu8ako	237	22	rate	rate	NN
cord-007444-c9vu8ako	237	23	(	(	-LRB-
cord-007444-c9vu8ako	237	24	P	p	NN
cord-007444-c9vu8ako	237	25	<	<	XX
cord-007444-c9vu8ako	237	26	0.02	0.02	CD
cord-007444-c9vu8ako	237	27	for	for	IN
cord-007444-c9vu8ako	237	28	both	both	DT
cord-007444-c9vu8ako	237	29	)	)	-RRB-
cord-007444-c9vu8ako	237	30	.	.	.
cord-007444-c9vu8ako	238	1	Treatment	treatment	NN
cord-007444-c9vu8ako	238	2	success	success	NN
cord-007444-c9vu8ako	238	3	,	,	,
cord-007444-c9vu8ako	238	4	defined	define	VBN
cord-007444-c9vu8ako	238	5	as	as	IN
cord-007444-c9vu8ako	238	6	resolution	resolution	NN
cord-007444-c9vu8ako	238	7	of	of	IN
cord-007444-c9vu8ako	238	8	symptoms	symptom	NNS
cord-007444-c9vu8ako	238	9	within	within	IN
cord-007444-c9vu8ako	238	10	21	21	CD
cord-007444-c9vu8ako	238	11	days	day	NNS
cord-007444-c9vu8ako	238	12	,	,	,
cord-007444-c9vu8ako	238	13	occurred	occur	VBD
cord-007444-c9vu8ako	238	14	in	in	IN
cord-007444-c9vu8ako	238	15	55	55	CD
cord-007444-c9vu8ako	238	16	%	%	NN
cord-007444-c9vu8ako	238	17	of	of	IN
cord-007444-c9vu8ako	238	18	the	the	DT
cord-007444-c9vu8ako	238	19	placebo	placebo	NN
cord-007444-c9vu8ako	238	20	group	group	NN
cord-007444-c9vu8ako	238	21	and	and	CC
cord-007444-c9vu8ako	238	22	68.1	68.1	CD
cord-007444-c9vu8ako	238	23	%	%	NN
cord-007444-c9vu8ako	238	24	of	of	IN
cord-007444-c9vu8ako	238	25	patients	patient	NNS
cord-007444-c9vu8ako	238	26	receiving	receive	VBG
cord-007444-c9vu8ako	238	27	active	active	JJ
cord-007444-c9vu8ako	238	28	treatment	treatment	NN
cord-007444-c9vu8ako	238	29	(	(	-LRB-
cord-007444-c9vu8ako	238	30	P	p	NN
cord-007444-c9vu8ako	238	31	<	<	XX
cord-007444-c9vu8ako	238	32	0.05	0.05	CD
cord-007444-c9vu8ako	238	33	)	)	-RRB-
cord-007444-c9vu8ako	238	34	.	.	.
cord-007444-c9vu8ako	239	1	Significantly	significantly	RB
cord-007444-c9vu8ako	239	2	,	,	,
cord-007444-c9vu8ako	239	3	among	among	IN
cord-007444-c9vu8ako	239	4	patients	patient	NNS
cord-007444-c9vu8ako	239	5	presenting	present	VBG
cord-007444-c9vu8ako	239	6	with	with	IN
cord-007444-c9vu8ako	239	7	type	type	NN
cord-007444-c9vu8ako	239	8	l	l	NNP
cord-007444-c9vu8ako	239	9	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	239	10	,	,	,
cord-007444-c9vu8ako	239	11	clinical	clinical	JJ
cord-007444-c9vu8ako	239	12	deterioration	deterioration	NN
cord-007444-c9vu8ako	239	13	was	be	VBD
cord-007444-c9vu8ako	239	14	more	more	JJR
cord-007444-c9vu8ako	239	15	than	than	IN
cord-007444-c9vu8ako	239	16	twice	twice	RB
cord-007444-c9vu8ako	239	17	as	as	RB
cord-007444-c9vu8ako	239	18	common	common	JJ
cord-007444-c9vu8ako	239	19	with	with	IN
cord-007444-c9vu8ako	239	20	placebo	placebo	NN
cord-007444-c9vu8ako	239	21	as	as	IN
cord-007444-c9vu8ako	239	22	with	with	IN
cord-007444-c9vu8ako	239	23	antibiotic	antibiotic	NN
cord-007444-c9vu8ako	239	24	.	.	.
cord-007444-c9vu8ako	240	1	A	a	DT
cord-007444-c9vu8ako	240	2	clinician	clinician	NN
cord-007444-c9vu8ako	240	3	therefore	therefore	RB
cord-007444-c9vu8ako	240	4	would	would	MD
cord-007444-c9vu8ako	240	5	need	need	VB
cord-007444-c9vu8ako	240	6	to	to	TO
cord-007444-c9vu8ako	240	7	treat	treat	VB
cord-007444-c9vu8ako	240	8	roughly	roughly	RB
cord-007444-c9vu8ako	240	9	eight	eight	CD
cord-007444-c9vu8ako	240	10	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	240	11	with	with	IN
cord-007444-c9vu8ako	240	12	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	240	13	to	to	TO
cord-007444-c9vu8ako	240	14	achieve	achieve	VB
cord-007444-c9vu8ako	240	15	one	one	CD
cord-007444-c9vu8ako	240	16	treatment	treatment	NN
cord-007444-c9vu8ako	240	17	success	success	NN
cord-007444-c9vu8ako	240	18	beyond	beyond	IN
cord-007444-c9vu8ako	240	19	chance	chance	NN
cord-007444-c9vu8ako	240	20	,	,	,
cord-007444-c9vu8ako	240	21	or	or	CC
cord-007444-c9vu8ako	240	22	two	two	CD
cord-007444-c9vu8ako	240	23	in	in	IN
cord-007444-c9vu8ako	240	24	order	order	NN
cord-007444-c9vu8ako	240	25	to	to	TO
cord-007444-c9vu8ako	240	26	avoid	avoid	VB
cord-007444-c9vu8ako	240	27	a	a	DT
cord-007444-c9vu8ako	240	28	single	single	JJ
cord-007444-c9vu8ako	240	29	deterioration	deterioration	NN
cord-007444-c9vu8ako	240	30	.	.	.
cord-007444-c9vu8ako	241	1	The	the	DT
cord-007444-c9vu8ako	241	2	authors	author	NNS
cord-007444-c9vu8ako	241	3	concluded	conclude	VBD
cord-007444-c9vu8ako	241	4	that	that	IN
cord-007444-c9vu8ako	241	5	avoidance	avoidance	NN
cord-007444-c9vu8ako	241	6	of	of	IN
cord-007444-c9vu8ako	241	7	deleterious	deleterious	JJ
cord-007444-c9vu8ako	241	8	outcomes	outcome	NNS
cord-007444-c9vu8ako	241	9	is	be	VBZ
cord-007444-c9vu8ako	241	10	the	the	DT
cord-007444-c9vu8ako	241	11	strongest	strong	JJS
cord-007444-c9vu8ako	241	12	reason	reason	NN
cord-007444-c9vu8ako	241	13	to	to	TO
cord-007444-c9vu8ako	241	14	offer	offer	VB
cord-007444-c9vu8ako	241	15	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	241	16	to	to	IN
cord-007444-c9vu8ako	241	17	patients	patient	NNS
cord-007444-c9vu8ako	241	18	with	with	IN
cord-007444-c9vu8ako	241	19	AE	AE	NNP
cord-007444-c9vu8ako	241	20	-	-	HYPH
cord-007444-c9vu8ako	241	21	COPD	COPD	NNP
cord-007444-c9vu8ako	241	22	.	.	.
cord-007444-c9vu8ako	242	1	Furthermore	furthermore	RB
cord-007444-c9vu8ako	242	2	,	,	,
cord-007444-c9vu8ako	242	3	they	-PRON-	PRP
cord-007444-c9vu8ako	242	4	stated	state	VBD
cord-007444-c9vu8ako	242	5	that	that	IN
cord-007444-c9vu8ako	242	6	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	242	7	are	be	VBP
cord-007444-c9vu8ako	242	8	clearly	clearly	RB
cord-007444-c9vu8ako	242	9	indicated	indicate	VBN
cord-007444-c9vu8ako	242	10	in	in	IN
cord-007444-c9vu8ako	242	11	type	type	NN
cord-007444-c9vu8ako	242	12	1	1	CD
cord-007444-c9vu8ako	242	13	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	242	14	,	,	,
cord-007444-c9vu8ako	242	15	of	of	IN
cord-007444-c9vu8ako	242	16	no	no	DT
cord-007444-c9vu8ako	242	17	benefit	benefit	NN
cord-007444-c9vu8ako	242	18	in	in	IN
cord-007444-c9vu8ako	242	19	type	type	NN
cord-007444-c9vu8ako	242	20	3	3	CD
cord-007444-c9vu8ako	242	21	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	242	22	,	,	,
cord-007444-c9vu8ako	242	23	and	and	CC
cord-007444-c9vu8ako	242	24	probably	probably	RB
cord-007444-c9vu8ako	242	25	justifiable	justifiable	JJ
cord-007444-c9vu8ako	242	26	for	for	IN
cord-007444-c9vu8ako	242	27	patients	patient	NNS
cord-007444-c9vu8ako	242	28	with	with	IN
cord-007444-c9vu8ako	242	29	type	type	NN
cord-007444-c9vu8ako	242	30	2	2	CD
cord-007444-c9vu8ako	242	31	presentations	presentation	NNS
cord-007444-c9vu8ako	242	32	.	.	.
cord-007444-c9vu8ako	243	1	"	"	''
cord-007444-c9vu8ako	244	1	Similar	similar	JJ
cord-007444-c9vu8ako	244	2	findings	finding	NNS
cord-007444-c9vu8ako	244	3	were	be	VBD
cord-007444-c9vu8ako	244	4	reported	report	VBN
cord-007444-c9vu8ako	244	5	in	in	IN
cord-007444-c9vu8ako	244	6	another	another	DT
cord-007444-c9vu8ako	244	7	largescale	largescale	JJ
cord-007444-c9vu8ako	244	8	,	,	,
cord-007444-c9vu8ako	244	9	randomized	randomized	JJ
cord-007444-c9vu8ako	244	10	trial	trial	NN
cord-007444-c9vu8ako	244	11	comparing	compare	VBG
cord-007444-c9vu8ako	244	12	amoxicillin	amoxicillin	NNP
cord-007444-c9vu8ako	244	13	/	/	SYM
cord-007444-c9vu8ako	244	14	clavulanate	clavulanate	NNP
cord-007444-c9vu8ako	244	15	to	to	IN
cord-007444-c9vu8ako	244	16	placebo	placebo	NN
cord-007444-c9vu8ako	244	17	?	?	.
cord-007444-c9vu8ako	244	18	,	,	,
cord-007444-c9vu8ako	245	1	Saint	Saint	NNP
cord-007444-c9vu8ako	245	2	and	and	CC
cord-007444-c9vu8ako	245	3	associate^'^^	associate^'^^	NNP
cord-007444-c9vu8ako	245	4	systematically	systematically	RB
cord-007444-c9vu8ako	245	5	reviewed	review	VBD
cord-007444-c9vu8ako	245	6	the	the	DT
cord-007444-c9vu8ako	245	7	clinical	clinical	JJ
cord-007444-c9vu8ako	245	8	efficacy	efficacy	NN
cord-007444-c9vu8ako	245	9	of	of	IN
cord-007444-c9vu8ako	245	10	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	245	11	for	for	IN
cord-007444-c9vu8ako	245	12	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	245	13	.	.	.
cord-007444-c9vu8ako	246	1	They	-PRON-	PRP
cord-007444-c9vu8ako	246	2	identified	identify	VBD
cord-007444-c9vu8ako	246	3	nine	nine	CD
cord-007444-c9vu8ako	246	4	randomized	randomized	JJ
cord-007444-c9vu8ako	246	5	,	,	,
cord-007444-c9vu8ako	246	6	placebo	placebo	NN
cord-007444-c9vu8ako	246	7	-	-	HYPH
cord-007444-c9vu8ako	246	8	controlled	control	VBN
cord-007444-c9vu8ako	246	9	trials	trial	NNS
cord-007444-c9vu8ako	246	10	of	of	IN
cord-007444-c9vu8ako	246	11	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	246	12	in	in	IN
cord-007444-c9vu8ako	246	13	COPD	COPD	NNP
cord-007444-c9vu8ako	246	14	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	246	15	in	in	IN
cord-007444-c9vu8ako	246	16	which	which	WDT
cord-007444-c9vu8ako	246	17	the	the	DT
cord-007444-c9vu8ako	246	18	patients	patient	NNS
cord-007444-c9vu8ako	246	19	were	be	VBD
cord-007444-c9vu8ako	246	20	followed	follow	VBN
cord-007444-c9vu8ako	246	21	for	for	IN
cord-007444-c9vu8ako	246	22	at	at	RB
cord-007444-c9vu8ako	246	23	least	least	JJS
cord-007444-c9vu8ako	246	24	5	5	CD
cord-007444-c9vu8ako	246	25	days	day	NNS
cord-007444-c9vu8ako	246	26	.	.	.
cord-007444-c9vu8ako	247	1	Because	because	IN
cord-007444-c9vu8ako	247	2	no	no	DT
cord-007444-c9vu8ako	247	3	outcome	outcome	NN
cord-007444-c9vu8ako	247	4	measure	measure	NN
cord-007444-c9vu8ako	247	5	was	be	VBD
cord-007444-c9vu8ako	247	6	common	common	JJ
cord-007444-c9vu8ako	247	7	to	to	IN
cord-007444-c9vu8ako	247	8	all	all	DT
cord-007444-c9vu8ako	247	9	nine	nine	CD
cord-007444-c9vu8ako	247	10	studies	study	NNS
cord-007444-c9vu8ako	247	11	,	,	,
cord-007444-c9vu8ako	247	12	the	the	DT
cord-007444-c9vu8ako	247	13	authors	author	NNS
cord-007444-c9vu8ako	247	14	derived	derive	VBD
cord-007444-c9vu8ako	247	15	an	an	DT
cord-007444-c9vu8ako	247	16	overall	overall	JJ
cord-007444-c9vu8ako	247	17	effect	effect	NN
cord-007444-c9vu8ako	247	18	size	size	NN
cord-007444-c9vu8ako	247	19	to	to	TO
cord-007444-c9vu8ako	247	20	quantify	quantify	VB
cord-007444-c9vu8ako	247	21	the	the	DT
cord-007444-c9vu8ako	247	22	efficacy	efficacy	NN
cord-007444-c9vu8ako	247	23	of	of	IN
cord-007444-c9vu8ako	247	24	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	247	25	and	and	CC
cord-007444-c9vu8ako	247	26	concluded	conclude	VBD
cord-007444-c9vu8ako	247	27	that	that	IN
cord-007444-c9vu8ako	247	28	a	a	DT
cord-007444-c9vu8ako	247	29	small	small	JJ
cord-007444-c9vu8ako	247	30	but	but	CC
cord-007444-c9vu8ako	247	31	statistically	statistically	RB
cord-007444-c9vu8ako	247	32	significant	significant	JJ
cord-007444-c9vu8ako	247	33	improvement	improvement	NN
cord-007444-c9vu8ako	247	34	could	could	MD
cord-007444-c9vu8ako	247	35	be	be	VB
cord-007444-c9vu8ako	247	36	expected	expect	VBN
cord-007444-c9vu8ako	247	37	among	among	IN
cord-007444-c9vu8ako	247	38	patients	patient	NNS
cord-007444-c9vu8ako	247	39	receiving	receive	VBG
cord-007444-c9vu8ako	247	40	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	247	41	.	.	.
cord-007444-c9vu8ako	248	1	From	from	IN
cord-007444-c9vu8ako	248	2	the	the	DT
cord-007444-c9vu8ako	248	3	six	six	CD
cord-007444-c9vu8ako	248	4	trials	trial	NNS
cord-007444-c9vu8ako	248	5	that	that	WDT
cord-007444-c9vu8ako	248	6	reported	report	VBD
cord-007444-c9vu8ako	248	7	peak	peak	JJ
cord-007444-c9vu8ako	248	8	expiratory	expiratory	JJ
cord-007444-c9vu8ako	248	9	flow	flow	NN
cord-007444-c9vu8ako	248	10	rates	rate	NNS
cord-007444-c9vu8ako	248	11	,	,	,
cord-007444-c9vu8ako	248	12	an	an	DT
cord-007444-c9vu8ako	248	13	overall	overall	JJ
cord-007444-c9vu8ako	248	14	improvement	improvement	NN
cord-007444-c9vu8ako	248	15	of	of	IN
cord-007444-c9vu8ako	248	16	10.75	10.75	CD
cord-007444-c9vu8ako	248	17	liters	liter	NNS
cord-007444-c9vu8ako	248	18	per	per	IN
cord-007444-c9vu8ako	248	19	minute	minute	NN
cord-007444-c9vu8ako	248	20	favoring	favor	VBG
cord-007444-c9vu8ako	248	21	the	the	DT
cord-007444-c9vu8ako	248	22	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	248	23	group	group	NN
cord-007444-c9vu8ako	248	24	was	be	VBD
cord-007444-c9vu8ako	248	25	noted	note	VBN
cord-007444-c9vu8ako	248	26	.	.	.
cord-007444-c9vu8ako	249	1	Although	although	IN
cord-007444-c9vu8ako	249	2	small	small	JJ
cord-007444-c9vu8ako	249	3	,	,	,
cord-007444-c9vu8ako	249	4	such	such	PDT
cord-007444-c9vu8ako	249	5	an	an	DT
cord-007444-c9vu8ako	249	6	effect	effect	NN
cord-007444-c9vu8ako	249	7	may	may	MD
cord-007444-c9vu8ako	249	8	be	be	VB
cord-007444-c9vu8ako	249	9	clinically	clinically	RB
cord-007444-c9vu8ako	249	10	important	important	JJ
cord-007444-c9vu8ako	249	11	for	for	IN
cord-007444-c9vu8ako	249	12	patients	patient	NNS
cord-007444-c9vu8ako	249	13	with	with	IN
cord-007444-c9vu8ako	249	14	severely	severely	RB
cord-007444-c9vu8ako	249	15	compromised	compromise	VBN
cord-007444-c9vu8ako	249	16	baseline	baseline	JJ
cord-007444-c9vu8ako	249	17	lung	lung	NN
cord-007444-c9vu8ako	249	18	function	function	NN
cord-007444-c9vu8ako	249	19	by	by	IN
cord-007444-c9vu8ako	249	20	preventing	prevent	VBG
cord-007444-c9vu8ako	249	21	respiratory	respiratory	JJ
cord-007444-c9vu8ako	249	22	failure	failure	NN
cord-007444-c9vu8ako	249	23	and	and	CC
cord-007444-c9vu8ako	249	24	hospital	hospital	NN
cord-007444-c9vu8ako	249	25	or	or	CC
cord-007444-c9vu8ako	249	26	intensive	intensive	JJ
cord-007444-c9vu8ako	249	27	care	care	NN
cord-007444-c9vu8ako	249	28	unit	unit	NN
cord-007444-c9vu8ako	249	29	(	(	-LRB-
cord-007444-c9vu8ako	249	30	ICU	ICU	NNP
cord-007444-c9vu8ako	249	31	)	)	-RRB-
cord-007444-c9vu8ako	249	32	admission.5l	admission.5l	VBD
cord-007444-c9vu8ako	249	33	To	to	TO
cord-007444-c9vu8ako	249	34	reduce	reduce	VB
cord-007444-c9vu8ako	249	35	the	the	DT
cord-007444-c9vu8ako	249	36	risk	risk	NN
cord-007444-c9vu8ako	249	37	for	for	IN
cord-007444-c9vu8ako	249	38	treatment	treatment	NN
cord-007444-c9vu8ako	249	39	failure	failure	NN
cord-007444-c9vu8ako	249	40	,	,	,
cord-007444-c9vu8ako	249	41	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	249	42	should	should	MD
cord-007444-c9vu8ako	249	43	be	be	VB
cord-007444-c9vu8ako	249	44	selected	select	VBN
cord-007444-c9vu8ako	249	45	according	accord	VBG
cord-007444-c9vu8ako	249	46	to	to	IN
cord-007444-c9vu8ako	249	47	pertinent	pertinent	JJ
cord-007444-c9vu8ako	249	48	clinical	clinical	JJ
cord-007444-c9vu8ako	249	49	data	datum	NNS
cord-007444-c9vu8ako	249	50	and	and	CC
cord-007444-c9vu8ako	249	51	the	the	DT
cord-007444-c9vu8ako	249	52	potential	potential	NN
cord-007444-c9vu8ako	249	53	for	for	IN
cord-007444-c9vu8ako	249	54	antimicrobial	antimicrobial	JJ
cord-007444-c9vu8ako	249	55	resistance	resistance	NN
cord-007444-c9vu8ako	249	56	.	.	.
cord-007444-c9vu8ako	250	1	Several	several	JJ
cord-007444-c9vu8ako	250	2	schemes	scheme	NNS
cord-007444-c9vu8ako	250	3	have	have	VBP
cord-007444-c9vu8ako	250	4	been	be	VBN
cord-007444-c9vu8ako	250	5	proposed	propose	VBN
cord-007444-c9vu8ako	250	6	to	to	TO
cord-007444-c9vu8ako	250	7	stratify	stratify	VB
cord-007444-c9vu8ako	250	8	the	the	DT
cord-007444-c9vu8ako	250	9	patient	patient	NN
cord-007444-c9vu8ako	250	10	's	's	POS
cord-007444-c9vu8ako	250	11	risk	risk	NN
cord-007444-c9vu8ako	250	12	and	and	CC
cord-007444-c9vu8ako	250	13	select	select	VB
cord-007444-c9vu8ako	250	14	the	the	DT
cord-007444-c9vu8ako	250	15	most	most	RBS
cord-007444-c9vu8ako	250	16	appropriate	appropriate	JJ
cord-007444-c9vu8ako	250	17	therapy	therapy	NN
cord-007444-c9vu8ako	250	18	.	.	.
cord-007444-c9vu8ako	250	19	'	'	''
cord-007444-c9vu8ako	251	1	"	"	``
cord-007444-c9vu8ako	251	2	53	53	CD
cord-007444-c9vu8ako	251	3	,	,	,
cord-007444-c9vu8ako	251	4	72	72	CD
cord-007444-c9vu8ako	251	5	,	,	,
cord-007444-c9vu8ako	251	6	The	the	DT
cord-007444-c9vu8ako	251	7	simplest	simple	JJS
cord-007444-c9vu8ako	251	8	,	,	,
cord-007444-c9vu8ako	251	9	and	and	CC
cord-007444-c9vu8ako	251	10	most	most	RBS
cord-007444-c9vu8ako	251	11	recent	recent	JJ
cord-007444-c9vu8ako	251	12	,	,	,
cord-007444-c9vu8ako	251	13	classification	classification	NN
cord-007444-c9vu8ako	251	14	system	system	NN
cord-007444-c9vu8ako	251	15	is	be	VBZ
cord-007444-c9vu8ako	251	16	presented	present	VBN
cord-007444-c9vu8ako	251	17	in	in	IN
cord-007444-c9vu8ako	251	18	Table	Table	NNP
cord-007444-c9vu8ako	251	19	 	 	_SP
cord-007444-c9vu8ako	251	20	3	3	CD
cord-007444-c9vu8ako	251	21	.	.	.
cord-007444-c9vu8ako	252	1	G	g	NN
cord-007444-c9vu8ako	253	1	r	r	LS
cord-007444-c9vu8ako	253	2	o	o	NN
cord-007444-c9vu8ako	254	1	s	s	NNP
cord-007444-c9vu8ako	255	1	~m	~m	NNP
cord-007444-c9vu8ako	255	2	a	a	DT
cord-007444-c9vu8ako	255	3	n~~	n~~	NN
cord-007444-c9vu8ako	255	4	has	have	VBZ
cord-007444-c9vu8ako	255	5	classified	classify	VBN
cord-007444-c9vu8ako	255	6	acute	acute	JJ
cord-007444-c9vu8ako	255	7	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	255	8	into	into	IN
cord-007444-c9vu8ako	255	9	four	four	CD
cord-007444-c9vu8ako	255	10	groups	group	NNS
cord-007444-c9vu8ako	255	11	.	.	.
cord-007444-c9vu8ako	256	1	Group	group	NN
cord-007444-c9vu8ako	256	2	1	1	CD
cord-007444-c9vu8ako	256	3	patients	patient	NNS
cord-007444-c9vu8ako	256	4	have	have	VBP
cord-007444-c9vu8ako	256	5	acute	acute	JJ
cord-007444-c9vu8ako	256	6	simple	simple	JJ
cord-007444-c9vu8ako	256	7	bronclutis	bronclutis	NN
cord-007444-c9vu8ako	256	8	,	,	,
cord-007444-c9vu8ako	256	9	likely	likely	JJ
cord-007444-c9vu8ako	256	10	of	of	IN
cord-007444-c9vu8ako	256	11	viral	viral	JJ
cord-007444-c9vu8ako	256	12	origin	origin	NN
cord-007444-c9vu8ako	256	13	,	,	,
cord-007444-c9vu8ako	256	14	for	for	IN
cord-007444-c9vu8ako	256	15	which	which	WDT
cord-007444-c9vu8ako	256	16	anti-	anti-	JJ
cord-007444-c9vu8ako	256	17	Antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	256	18	therapy	therapy	NN
cord-007444-c9vu8ako	256	19	is	be	VBZ
cord-007444-c9vu8ako	256	20	directed	direct	VBN
cord-007444-c9vu8ako	256	21	at	at	IN
cord-007444-c9vu8ako	256	22	l	l	NNP
cord-007444-c9vu8ako	256	23	?	?	.
cord-007444-c9vu8ako	256	24	aeruginosa	aeruginosa	NN
cord-007444-c9vu8ako	256	25	and	and	CC
cord-007444-c9vu8ako	256	26	other	other	JJ
cord-007444-c9vu8ako	256	27	commonly	commonly	RB
cord-007444-c9vu8ako	256	28	drug	drug	NN
cord-007444-c9vu8ako	256	29	-	-	HYPH
cord-007444-c9vu8ako	256	30	resistant	resistant	JJ
cord-007444-c9vu8ako	256	31	gram	gram	NN
cord-007444-c9vu8ako	256	32	-	-	HYPH
cord-007444-c9vu8ako	256	33	negative	negative	JJ
cord-007444-c9vu8ako	256	34	bacteria	bacteria	NNS
cord-007444-c9vu8ako	256	35	(	(	-LRB-
cord-007444-c9vu8ako	256	36	see	see	VB
cord-007444-c9vu8ako	256	37	Table	Table	NNP
cord-007444-c9vu8ako	256	38	3	3	CD
cord-007444-c9vu8ako	256	39	)	)	-RRB-
cord-007444-c9vu8ako	256	40	.	.	.
cord-007444-c9vu8ako	257	1	As	as	IN
cord-007444-c9vu8ako	257	2	noted	note	VBN
cord-007444-c9vu8ako	257	3	,	,	,
cord-007444-c9vu8ako	257	4	approaches	approach	VBZ
cord-007444-c9vu8ako	257	5	to	to	IN
cord-007444-c9vu8ako	257	6	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	257	7	therapy	therapy	NN
cord-007444-c9vu8ako	257	8	based	base	VBN
cord-007444-c9vu8ako	257	9	upon	upon	IN
cord-007444-c9vu8ako	257	10	a	a	DT
cord-007444-c9vu8ako	257	11	rational	rational	JJ
cord-007444-c9vu8ako	257	12	appraisal	appraisal	NN
cord-007444-c9vu8ako	257	13	of	of	IN
cord-007444-c9vu8ako	257	14	patient	patient	JJ
cord-007444-c9vu8ako	257	15	risk	risk	NN
cord-007444-c9vu8ako	257	16	factors	factor	NNS
cord-007444-c9vu8ako	257	17	and	and	CC
cord-007444-c9vu8ako	257	18	likely	likely	JJ
cord-007444-c9vu8ako	257	19	pathogens	pathogen	NNS
cord-007444-c9vu8ako	257	20	reduce	reduce	VBP
cord-007444-c9vu8ako	257	21	the	the	DT
cord-007444-c9vu8ako	257	22	risk	risk	NN
cord-007444-c9vu8ako	257	23	for	for	IN
cord-007444-c9vu8ako	257	24	treatment	treatment	NN
cord-007444-c9vu8ako	257	25	failure	failure	NN
cord-007444-c9vu8ako	257	26	and	and	CC
cord-007444-c9vu8ako	257	27	avoid	avoid	VB
cord-007444-c9vu8ako	257	28	unnecessary	unnecessary	JJ
cord-007444-c9vu8ako	257	29	medical	medical	JJ
cord-007444-c9vu8ako	257	30	and	and	CC
cord-007444-c9vu8ako	257	31	economic	economic	JJ
cord-007444-c9vu8ako	257	32	expense	expense	NN
cord-007444-c9vu8ako	257	33	.	.	.
cord-007444-c9vu8ako	258	1	There	there	EX
cord-007444-c9vu8ako	258	2	are	be	VBP
cord-007444-c9vu8ako	258	3	outcome	outcome	NN
cord-007444-c9vu8ako	258	4	data	datum	NNS
cord-007444-c9vu8ako	258	5	to	to	TO
cord-007444-c9vu8ako	258	6	suggest	suggest	VB
cord-007444-c9vu8ako	258	7	this	this	DT
cord-007444-c9vu8ako	258	8	approach	approach	NN
cord-007444-c9vu8ako	258	9	leads	lead	VBZ
cord-007444-c9vu8ako	258	10	to	to	IN
cord-007444-c9vu8ako	258	11	improved	improve	VBN
cord-007444-c9vu8ako	258	12	clinical	clinical	JJ
cord-007444-c9vu8ako	258	13	outcomes	outcome	NNS
cord-007444-c9vu8ako	258	14	,	,	,
cord-007444-c9vu8ako	258	15	with	with	IN
cord-007444-c9vu8ako	258	16	reduced	reduce	VBN
cord-007444-c9vu8ako	258	17	overall	overall	RB
cord-007444-c9vu8ako	258	18	A	a	DT
cord-007444-c9vu8ako	258	19	retrospective	retrospective	JJ
cord-007444-c9vu8ako	258	20	study	study	NN
cord-007444-c9vu8ako	258	21	by	by	IN
cord-007444-c9vu8ako	258	22	Destache	Destache	NNP
cord-007444-c9vu8ako	258	23	and	and	CC
cord-007444-c9vu8ako	258	24	colleagues37	colleagues37	NNP
cord-007444-c9vu8ako	258	25	demonstrated	demonstrate	VBD
cord-007444-c9vu8ako	258	26	that	that	IN
cord-007444-c9vu8ako	258	27	,	,	,
cord-007444-c9vu8ako	258	28	compared	compare	VBN
cord-007444-c9vu8ako	258	29	with	with	IN
cord-007444-c9vu8ako	258	30	the	the	DT
cord-007444-c9vu8ako	258	31	usual	usual	JJ
cord-007444-c9vu8ako	258	32	first	first	JJ
cord-007444-c9vu8ako	258	33	-	-	HYPH
cord-007444-c9vu8ako	258	34	line	line	NN
cord-007444-c9vu8ako	258	35	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	258	36	in	in	IN
cord-007444-c9vu8ako	258	37	the	the	DT
cord-007444-c9vu8ako	258	38	treatment	treatment	NN
cord-007444-c9vu8ako	258	39	of	of	IN
cord-007444-c9vu8ako	258	40	acute	acute	JJ
cord-007444-c9vu8ako	258	41	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	258	42	of	of	IN
cord-007444-c9vu8ako	258	43	chronic	chronic	JJ
cord-007444-c9vu8ako	258	44	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	258	45	,	,	,
cord-007444-c9vu8ako	258	46	the	the	DT
cord-007444-c9vu8ako	258	47	use	use	NN
cord-007444-c9vu8ako	258	48	of	of	IN
cord-007444-c9vu8ako	258	49	newer	new	JJR
cord-007444-c9vu8ako	258	50	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	258	51	reduced	reduce	VBD
cord-007444-c9vu8ako	258	52	both	both	CC
cord-007444-c9vu8ako	258	53	the	the	DT
cord-007444-c9vu8ako	258	54	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	258	55	rate	rate	NN
cord-007444-c9vu8ako	258	56	and	and	CC
cord-007444-c9vu8ako	258	57	failure	failure	NN
cord-007444-c9vu8ako	258	58	rate	rate	NN
cord-007444-c9vu8ako	258	59	.	.	.
cord-007444-c9vu8ako	259	1	Although	although	IN
cord-007444-c9vu8ako	259	2	the	the	DT
cord-007444-c9vu8ako	259	3	acquisition	acquisition	NN
cord-007444-c9vu8ako	259	4	cost	cost	NN
cord-007444-c9vu8ako	259	5	of	of	IN
cord-007444-c9vu8ako	259	6	newer	new	JJR
cord-007444-c9vu8ako	259	7	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	259	8	(	(	-LRB-
cord-007444-c9vu8ako	259	9	cephalosporins	cephalosporin	NNS
cord-007444-c9vu8ako	259	10	,	,	,
cord-007444-c9vu8ako	259	11	macrolides	macrolide	NNS
cord-007444-c9vu8ako	259	12	and	and	CC
cord-007444-c9vu8ako	259	13	fluoroquinolones	fluoroquinolone	NNS
cord-007444-c9vu8ako	259	14	)	)	-RRB-
cord-007444-c9vu8ako	259	15	was	be	VBD
cord-007444-c9vu8ako	259	16	higher	high	JJR
cord-007444-c9vu8ako	259	17	,	,	,
cord-007444-c9vu8ako	259	18	the	the	DT
cord-007444-c9vu8ako	259	19	overall	overall	JJ
cord-007444-c9vu8ako	259	20	costs	cost	NNS
cord-007444-c9vu8ako	259	21	of	of	IN
cord-007444-c9vu8ako	259	22	the	the	DT
cord-007444-c9vu8ako	259	23	treated	treat	VBN
cord-007444-c9vu8ako	259	24	patients	patient	NNS
cord-007444-c9vu8ako	259	25	given	give	VBN
cord-007444-c9vu8ako	259	26	these	these	DT
cord-007444-c9vu8ako	259	27	drugs	drug	NNS
cord-007444-c9vu8ako	259	28	were	be	VBD
cord-007444-c9vu8ako	259	29	lower	low	JJR
cord-007444-c9vu8ako	259	30	.	.	.
cord-007444-c9vu8ako	260	1	In	in	IN
cord-007444-c9vu8ako	260	2	particular	particular	JJ
cord-007444-c9vu8ako	260	3	,	,	,
cord-007444-c9vu8ako	260	4	the	the	DT
cord-007444-c9vu8ako	260	5	group	group	NN
cord-007444-c9vu8ako	260	6	receiving	receive	VBG
cord-007444-c9vu8ako	260	7	amoxicillin/	amoxicillin/	NN
cord-007444-c9vu8ako	260	8	clavulanate	clavulanate	NN
cord-007444-c9vu8ako	260	9	,	,	,
cord-007444-c9vu8ako	260	10	azithromycin	azithromycin	NNP
cord-007444-c9vu8ako	260	11	,	,	,
cord-007444-c9vu8ako	260	12	or	or	CC
cord-007444-c9vu8ako	260	13	ciprofloxacin	ciprofloxacin	NN
cord-007444-c9vu8ako	260	14	had	have	VBD
cord-007444-c9vu8ako	260	15	the	the	DT
cord-007444-c9vu8ako	260	16	lowest	low	JJS
cord-007444-c9vu8ako	260	17	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	260	18	rate	rate	NN
cord-007444-c9vu8ako	260	19	,	,	,
cord-007444-c9vu8ako	260	20	clinical	clinical	JJ
cord-007444-c9vu8ako	260	21	failure	failure	NN
cord-007444-c9vu8ako	260	22	rate	rate	NN
cord-007444-c9vu8ako	260	23	,	,	,
cord-007444-c9vu8ako	260	24	and	and	CC
cord-007444-c9vu8ako	260	25	costs	cost	NNS
cord-007444-c9vu8ako	260	26	compared	compare	VBN
cord-007444-c9vu8ako	260	27	with	with	IN
cord-007444-c9vu8ako	260	28	cephalosporins	cephalosporin	NNS
cord-007444-c9vu8ako	260	29	or	or	CC
cord-007444-c9vu8ako	260	30	first	first	JJ
cord-007444-c9vu8ako	260	31	-	-	HYPH
cord-007444-c9vu8ako	260	32	line	line	NN
cord-007444-c9vu8ako	260	33	therapy	therapy	NN
cord-007444-c9vu8ako	260	34	.	.	.
cord-007444-c9vu8ako	261	1	The	the	DT
cord-007444-c9vu8ako	261	2	hypothesis	hypothesis	NN
cord-007444-c9vu8ako	261	3	that	that	WDT
cord-007444-c9vu8ako	261	4	aggressive	aggressive	JJ
cord-007444-c9vu8ako	261	5	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	261	6	therapy	therapy	NN
cord-007444-c9vu8ako	261	7	should	should	MD
cord-007444-c9vu8ako	261	8	be	be	VB
cord-007444-c9vu8ako	261	9	offered	offer	VBN
cord-007444-c9vu8ako	261	10	to	to	IN
cord-007444-c9vu8ako	261	11	high	high	JJ
cord-007444-c9vu8ako	261	12	-	-	HYPH
cord-007444-c9vu8ako	261	13	risk	risk	NN
cord-007444-c9vu8ako	261	14	patients	patient	NNS
cord-007444-c9vu8ako	261	15	was	be	VBD
cord-007444-c9vu8ako	261	16	tested	test	VBN
cord-007444-c9vu8ako	261	17	in	in	IN
cord-007444-c9vu8ako	261	18	a	a	DT
cord-007444-c9vu8ako	261	19	recent	recent	JJ
cord-007444-c9vu8ako	261	20	,	,	,
cord-007444-c9vu8ako	261	21	prospective	prospective	JJ
cord-007444-c9vu8ako	261	22	,	,	,
cord-007444-c9vu8ako	261	23	health	health	NN
cord-007444-c9vu8ako	261	24	economic	economic	JJ
cord-007444-c9vu8ako	261	25	study.=	study.=	NN
cord-007444-c9vu8ako	261	26	Patients	patient	NNS
cord-007444-c9vu8ako	261	27	with	with	IN
cord-007444-c9vu8ako	261	28	at	at	RB
cord-007444-c9vu8ako	261	29	least	least	RBS
cord-007444-c9vu8ako	261	30	three	three	CD
cord-007444-c9vu8ako	261	31	treated	treat	VBN
cord-007444-c9vu8ako	261	32	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	261	33	of	of	IN
cord-007444-c9vu8ako	261	34	chronic	chronic	JJ
cord-007444-c9vu8ako	261	35	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	261	36	in	in	IN
cord-007444-c9vu8ako	261	37	the	the	DT
cord-007444-c9vu8ako	261	38	past	past	JJ
cord-007444-c9vu8ako	261	39	year	year	NN
cord-007444-c9vu8ako	261	40	were	be	VBD
cord-007444-c9vu8ako	261	41	randomized	randomize	VBN
cord-007444-c9vu8ako	261	42	to	to	TO
cord-007444-c9vu8ako	261	43	receive	receive	VB
cord-007444-c9vu8ako	261	44	either	either	CC
cord-007444-c9vu8ako	261	45	ciprofloxacin	ciprofloxacin	NN
cord-007444-c9vu8ako	261	46	or	or	CC
cord-007444-c9vu8ako	261	47	any	any	DT
cord-007444-c9vu8ako	261	48	nonquinolone	nonquinolone	NN
cord-007444-c9vu8ako	261	49	-	-	HYPH
cord-007444-c9vu8ako	261	50	based	base	VBN
cord-007444-c9vu8ako	261	51	therapy	therapy	NN
cord-007444-c9vu8ako	261	52	for	for	IN
cord-007444-c9vu8ako	261	53	their	-PRON-	PRP$
cord-007444-c9vu8ako	261	54	next	next	JJ
cord-007444-c9vu8ako	261	55	acute	acute	JJ
cord-007444-c9vu8ako	261	56	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	261	57	.	.	.
cord-007444-c9vu8ako	262	1	Clinical	clinical	JJ
cord-007444-c9vu8ako	262	2	endpoints	endpoint	NNS
cord-007444-c9vu8ako	262	3	(	(	-LRB-
cord-007444-c9vu8ako	262	4	days	day	NNS
cord-007444-c9vu8ako	262	5	of	of	IN
cord-007444-c9vu8ako	262	6	illness	illness	NN
cord-007444-c9vu8ako	262	7	,	,	,
cord-007444-c9vu8ako	262	8	hospitalizations	hospitalization	NNS
cord-007444-c9vu8ako	262	9	,	,	,
cord-007444-c9vu8ako	262	10	time	time	NN
cord-007444-c9vu8ako	262	11	to	to	IN
cord-007444-c9vu8ako	262	12	next	next	JJ
cord-007444-c9vu8ako	262	13	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	262	14	)	)	-RRB-
cord-007444-c9vu8ako	262	15	were	be	VBD
cord-007444-c9vu8ako	262	16	blended	blend	VBN
cord-007444-c9vu8ako	262	17	with	with	IN
cord-007444-c9vu8ako	262	18	quality	quality	NN
cord-007444-c9vu8ako	262	19	-	-	HYPH
cord-007444-c9vu8ako	262	20	of	of	IN
cord-007444-c9vu8ako	262	21	-	-	HYPH
cord-007444-c9vu8ako	262	22	life	life	NN
cord-007444-c9vu8ako	262	23	measurements	measurement	NNS
cord-007444-c9vu8ako	262	24	(	(	-LRB-
cord-007444-c9vu8ako	262	25	Nottingham	Nottingham	NNP
cord-007444-c9vu8ako	262	26	Health	Health	NNP
cord-007444-c9vu8ako	262	27	Profile	Profile	NNP
cord-007444-c9vu8ako	262	28	,	,	,
cord-007444-c9vu8ako	262	29	St.	St.	NNP
cord-007444-c9vu8ako	262	30	George	George	NNP
cord-007444-c9vu8ako	262	31	's	's	POS
cord-007444-c9vu8ako	262	32	Hospital	Hospital	NNP
cord-007444-c9vu8ako	262	33	Respiratory	Respiratory	NNP
cord-007444-c9vu8ako	262	34	Questionnaire	Questionnaire	NNP
cord-007444-c9vu8ako	262	35	,	,	,
cord-007444-c9vu8ako	262	36	Health	Health	NNP
cord-007444-c9vu8ako	262	37	Utility	Utility	NNP
cord-007444-c9vu8ako	262	38	Index	Index	NNP
cord-007444-c9vu8ako	262	39	)	)	-RRB-
cord-007444-c9vu8ako	262	40	,	,	,
cord-007444-c9vu8ako	262	41	and	and	CC
cord-007444-c9vu8ako	262	42	total	total	JJ
cord-007444-c9vu8ako	262	43	respiratory	respiratory	JJ
cord-007444-c9vu8ako	262	44	costs	cost	NNS
cord-007444-c9vu8ako	262	45	from	from	IN
cord-007444-c9vu8ako	262	46	a	a	DT
cord-007444-c9vu8ako	262	47	societal	societal	JJ
cord-007444-c9vu8ako	262	48	perspective	perspective	NN
cord-007444-c9vu8ako	262	49	.	.	.
cord-007444-c9vu8ako	263	1	Although	although	IN
cord-007444-c9vu8ako	263	2	the	the	DT
cord-007444-c9vu8ako	263	3	overall	overall	JJ
cord-007444-c9vu8ako	263	4	results	result	NNS
cord-007444-c9vu8ako	263	5	indicated	indicate	VBD
cord-007444-c9vu8ako	263	6	no	no	DT
cord-007444-c9vu8ako	263	7	advantage	advantage	NN
cord-007444-c9vu8ako	263	8	for	for	IN
cord-007444-c9vu8ako	263	9	either	either	DT
cord-007444-c9vu8ako	263	10	treatment	treatment	NN
cord-007444-c9vu8ako	263	11	arm	arm	NN
cord-007444-c9vu8ako	263	12	,	,	,
cord-007444-c9vu8ako	263	13	in	in	IN
cord-007444-c9vu8ako	263	14	patients	patient	NNS
cord-007444-c9vu8ako	263	15	with	with	IN
cord-007444-c9vu8ako	263	16	risk	risk	NN
cord-007444-c9vu8ako	263	17	factors	factor	NNS
cord-007444-c9vu8ako	263	18	(	(	-LRB-
cord-007444-c9vu8ako	263	19	severe	severe	JJ
cord-007444-c9vu8ako	263	20	underlying	underlying	JJ
cord-007444-c9vu8ako	263	21	lung	lung	NN
cord-007444-c9vu8ako	263	22	disease	disease	NN
cord-007444-c9vu8ako	263	23	,	,	,
cord-007444-c9vu8ako	263	24	more	more	JJR
cord-007444-c9vu8ako	263	25	than	than	IN
cord-007444-c9vu8ako	263	26	four	four	CD
cord-007444-c9vu8ako	263	27	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	263	28	per	per	IN
cord-007444-c9vu8ako	263	29	year	year	NN
cord-007444-c9vu8ako	263	30	,	,	,
cord-007444-c9vu8ako	263	31	duration	duration	NN
cord-007444-c9vu8ako	263	32	of	of	IN
cord-007444-c9vu8ako	263	33	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	263	34	greater	great	JJR
cord-007444-c9vu8ako	263	35	than	than	IN
cord-007444-c9vu8ako	263	36	10	10	CD
cord-007444-c9vu8ako	263	37	years	year	NNS
cord-007444-c9vu8ako	263	38	,	,	,
cord-007444-c9vu8ako	263	39	elderly	elderly	JJ
cord-007444-c9vu8ako	263	40	,	,	,
cord-007444-c9vu8ako	263	41	significant	significant	JJ
cord-007444-c9vu8ako	263	42	comorbid	comorbid	NN
cord-007444-c9vu8ako	263	43	illness	illness	NN
cord-007444-c9vu8ako	263	44	)	)	-RRB-
cord-007444-c9vu8ako	264	1	the	the	DT
cord-007444-c9vu8ako	264	2	use	use	NN
cord-007444-c9vu8ako	264	3	of	of	IN
cord-007444-c9vu8ako	264	4	ciprofloxacin	ciprofloxacin	NN
cord-007444-c9vu8ako	264	5	led	lead	VBN
cord-007444-c9vu8ako	264	6	to	to	IN
cord-007444-c9vu8ako	264	7	improved	improve	VBN
cord-007444-c9vu8ako	264	8	clinical	clinical	JJ
cord-007444-c9vu8ako	264	9	outcome	outcome	NN
cord-007444-c9vu8ako	264	10	,	,	,
cord-007444-c9vu8ako	264	11	higher	high	JJR
cord-007444-c9vu8ako	264	12	quality	quality	NN
cord-007444-c9vu8ako	264	13	of	of	IN
cord-007444-c9vu8ako	264	14	life	life	NN
cord-007444-c9vu8ako	264	15	,	,	,
cord-007444-c9vu8ako	264	16	and	and	CC
cord-007444-c9vu8ako	264	17	fewer	few	JJR
cord-007444-c9vu8ako	264	18	costs	cost	NNS
cord-007444-c9vu8ako	264	19	.	.	.
cord-007444-c9vu8ako	265	1	The	the	DT
cord-007444-c9vu8ako	265	2	results	result	NNS
cord-007444-c9vu8ako	265	3	of	of	IN
cord-007444-c9vu8ako	265	4	this	this	DT
cord-007444-c9vu8ako	265	5	study	study	NN
cord-007444-c9vu8ako	265	6	would	would	MD
cord-007444-c9vu8ako	265	7	suggest	suggest	VB
cord-007444-c9vu8ako	265	8	that	that	IN
cord-007444-c9vu8ako	265	9	aggressive	aggressive	JJ
cord-007444-c9vu8ako	265	10	antimicrobial	antimicrobial	JJ
cord-007444-c9vu8ako	265	11	therapy	therapy	NN
cord-007444-c9vu8ako	265	12	directed	direct	VBN
cord-007444-c9vu8ako	265	13	especially	especially	RB
cord-007444-c9vu8ako	265	14	toward	toward	IN
cord-007444-c9vu8ako	265	15	resistant	resistant	JJ
cord-007444-c9vu8ako	265	16	organisms	organism	NNS
cord-007444-c9vu8ako	265	17	in	in	IN
cord-007444-c9vu8ako	265	18	high	high	JJ
cord-007444-c9vu8ako	265	19	-	-	HYPH
cord-007444-c9vu8ako	265	20	risk	risk	NN
cord-007444-c9vu8ako	265	21	patients	patient	NNS
cord-007444-c9vu8ako	265	22	is	be	VBZ
cord-007444-c9vu8ako	265	23	a	a	DT
cord-007444-c9vu8ako	265	24	more	more	RBR
cord-007444-c9vu8ako	265	25	effective	effective	JJ
cord-007444-c9vu8ako	265	26	strategy	strategy	NN
cord-007444-c9vu8ako	265	27	than	than	IN
cord-007444-c9vu8ako	265	28	no	no	DT
cord-007444-c9vu8ako	265	29	therapy	therapy	NN
cord-007444-c9vu8ako	265	30	or	or	CC
cord-007444-c9vu8ako	265	31	therapy	therapy	NN
cord-007444-c9vu8ako	265	32	with	with	IN
cord-007444-c9vu8ako	265	33	older	old	JJR
cord-007444-c9vu8ako	265	34	antimicrobials	antimicrobial	NNS
cord-007444-c9vu8ako	265	35	that	that	WDT
cord-007444-c9vu8ako	265	36	would	would	MD
cord-007444-c9vu8ako	265	37	not	not	RB
cord-007444-c9vu8ako	265	38	be	be	VB
cord-007444-c9vu8ako	265	39	effective	effective	JJ
cord-007444-c9vu8ako	265	40	against	against	IN
cord-007444-c9vu8ako	265	41	the	the	DT
cord-007444-c9vu8ako	265	42	usual	usual	JJ
cord-007444-c9vu8ako	265	43	target	target	NN
cord-007444-c9vu8ako	265	44	organisms	organism	NNS
cord-007444-c9vu8ako	265	45	,	,	,
cord-007444-c9vu8ako	265	46	particularly	particularly	RB
cord-007444-c9vu8ako	265	47	P	p	NN
cord-007444-c9vu8ako	265	48	-	-	HYPH
cord-007444-c9vu8ako	265	49	lactamase	lactamase	NN
cord-007444-c9vu8ako	265	50	-	-	HYPH
cord-007444-c9vu8ako	265	51	producing	produce	VBG
cord-007444-c9vu8ako	265	52	H.	h.	NN
cord-007444-c9vu8ako	265	53	influenzae	influenzae	NN
cord-007444-c9vu8ako	265	54	.	.	.
cord-007444-c9vu8ako	266	1	Further	further	JJ
cord-007444-c9vu8ako	266	2	studies	study	NNS
cord-007444-c9vu8ako	266	3	are	be	VBP
cord-007444-c9vu8ako	266	4	needed	need	VBN
cord-007444-c9vu8ako	266	5	to	to	TO
cord-007444-c9vu8ako	266	6	clarify	clarify	VB
cord-007444-c9vu8ako	266	7	the	the	DT
cord-007444-c9vu8ako	266	8	optimal	optimal	JJ
cord-007444-c9vu8ako	266	9	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	266	10	treatment	treatment	NN
cord-007444-c9vu8ako	266	11	regimens	regimen	NNS
cord-007444-c9vu8ako	266	12	for	for	IN
cord-007444-c9vu8ako	266	13	subgroups	subgroup	NNS
cord-007444-c9vu8ako	266	14	of	of	IN
cord-007444-c9vu8ako	266	15	patients	patient	NNS
cord-007444-c9vu8ako	266	16	with	with	IN
cord-007444-c9vu8ako	266	17	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	266	18	.	.	.
cord-007444-c9vu8ako	267	1	Randomized	randomized	JJ
cord-007444-c9vu8ako	267	2	,	,	,
cord-007444-c9vu8ako	267	3	controlled	control	VBN
cord-007444-c9vu8ako	267	4	trials	trial	NNS
cord-007444-c9vu8ako	267	5	of	of	IN
cord-007444-c9vu8ako	267	6	the	the	DT
cord-007444-c9vu8ako	267	7	efficacy	efficacy	NN
cord-007444-c9vu8ako	267	8	of	of	IN
cord-007444-c9vu8ako	267	9	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	267	10	for	for	IN
cord-007444-c9vu8ako	267	11	acute	acute	JJ
cord-007444-c9vu8ako	267	12	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	267	13	of	of	IN
cord-007444-c9vu8ako	267	14	COPD	COPD	NNP
cord-007444-c9vu8ako	267	15	are	be	VBP
cord-007444-c9vu8ako	267	16	summarized	summarize	VBN
cord-007444-c9vu8ako	267	17	in	in	IN
cord-007444-c9vu8ako	267	18	Table	Table	NNP
cord-007444-c9vu8ako	267	19	4	4	CD
cord-007444-c9vu8ako	267	20	.	.	.
cord-007444-c9vu8ako	268	1	Their	-PRON-	PRP$
cord-007444-c9vu8ako	268	2	role	role	NN
cord-007444-c9vu8ako	268	3	in	in	IN
cord-007444-c9vu8ako	268	4	outpatient	outpatient	NN
cord-007444-c9vu8ako	268	5	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	268	6	has	have	VBZ
cord-007444-c9vu8ako	268	7	been	be	VBN
cord-007444-c9vu8ako	268	8	evaluated	evaluate	VBN
cord-007444-c9vu8ako	268	9	in	in	IN
cord-007444-c9vu8ako	268	10	only	only	RB
cord-007444-c9vu8ako	268	11	one	one	CD
cord-007444-c9vu8ako	268	12	small	small	JJ
cord-007444-c9vu8ako	268	13	study.lZ5	study.lZ5	NNS
cord-007444-c9vu8ako	268	14	Compared	compare	VBN
cord-007444-c9vu8ako	268	15	with	with	IN
cord-007444-c9vu8ako	268	16	placebo	placebo	NN
cord-007444-c9vu8ako	268	17	,	,	,
cord-007444-c9vu8ako	268	18	oral	oral	JJ
cord-007444-c9vu8ako	268	19	prednisone	prednisone	NNP
cord-007444-c9vu8ako	268	20	(	(	-LRB-
cord-007444-c9vu8ako	268	21	60	60	CD
cord-007444-c9vu8ako	268	22	mg	mg	NN
cord-007444-c9vu8ako	268	23	tapered	taper	VBD
cord-007444-c9vu8ako	268	24	to	to	IN
cord-007444-c9vu8ako	268	25	0	0	CD
cord-007444-c9vu8ako	268	26	mg	mg	NN
cord-007444-c9vu8ako	268	27	over	over	IN
cord-007444-c9vu8ako	268	28	9	9	CD
cord-007444-c9vu8ako	268	29	days	day	NNS
cord-007444-c9vu8ako	268	30	)	)	-RRB-
cord-007444-c9vu8ako	268	31	significantly	significantly	RB
cord-007444-c9vu8ako	268	32	improved	improve	VBD
cord-007444-c9vu8ako	268	33	airflow	airflow	NN
cord-007444-c9vu8ako	268	34	and	and	CC
cord-007444-c9vu8ako	268	35	oxygenation	oxygenation	NN
cord-007444-c9vu8ako	268	36	and	and	CC
cord-007444-c9vu8ako	268	37	resulted	result	VBD
cord-007444-c9vu8ako	268	38	in	in	IN
cord-007444-c9vu8ako	268	39	fewer	few	JJR
cord-007444-c9vu8ako	268	40	treatment	treatment	NN
cord-007444-c9vu8ako	268	41	failures	failure	NNS
cord-007444-c9vu8ako	268	42	.	.	.
cord-007444-c9vu8ako	269	1	FEV	FEV	NNP
cord-007444-c9vu8ako	269	2	,	,	,
cord-007444-c9vu8ako	269	3	improved	improve	VBD
cord-007444-c9vu8ako	269	4	on	on	IN
cord-007444-c9vu8ako	269	5	average	average	NN
cord-007444-c9vu8ako	269	6	by	by	IN
cord-007444-c9vu8ako	269	7	only	only	RB
cord-007444-c9vu8ako	269	8	50	50	CD
cord-007444-c9vu8ako	269	9	mL	ml	NN
cord-007444-c9vu8ako	269	10	per	per	IN
cord-007444-c9vu8ako	269	11	day	day	NN
cord-007444-c9vu8ako	269	12	among	among	IN
cord-007444-c9vu8ako	269	13	patients	patient	NNS
cord-007444-c9vu8ako	269	14	receiving	receive	VBG
cord-007444-c9vu8ako	269	15	prednis0ne.9~	prednis0ne.9~	ADD
cord-007444-c9vu8ako	269	16	These	these	DT
cord-007444-c9vu8ako	269	17	findings	finding	NNS
cord-007444-c9vu8ako	269	18	support	support	VBP
cord-007444-c9vu8ako	269	19	earlier	early	JJR
cord-007444-c9vu8ako	269	20	retrospective	retrospective	JJ
cord-007444-c9vu8ako	269	21	data	datum	NNS
cord-007444-c9vu8ako	269	22	that	that	WDT
cord-007444-c9vu8ako	269	23	suggest	suggest	VBP
cord-007444-c9vu8ako	269	24	that	that	IN
cord-007444-c9vu8ako	269	25	,	,	,
cord-007444-c9vu8ako	269	26	among	among	IN
cord-007444-c9vu8ako	269	27	patients	patient	NNS
cord-007444-c9vu8ako	269	28	with	with	IN
cord-007444-c9vu8ako	269	29	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	269	30	presenting	present	VBG
cord-007444-c9vu8ako	269	31	to	to	IN
cord-007444-c9vu8ako	269	32	an	an	DT
cord-007444-c9vu8ako	269	33	emergency	emergency	NN
cord-007444-c9vu8ako	269	34	department	department	NN
cord-007444-c9vu8ako	269	35	(	(	-LRB-
cord-007444-c9vu8ako	269	36	ED	ED	NNP
cord-007444-c9vu8ako	269	37	)	)	-RRB-
cord-007444-c9vu8ako	269	38	,	,	,
cord-007444-c9vu8ako	269	39	the	the	DT
cord-007444-c9vu8ako	269	40	incidence	incidence	NN
cord-007444-c9vu8ako	269	41	of	of	IN
cord-007444-c9vu8ako	269	42	revisit	revisit	NN
cord-007444-c9vu8ako	269	43	to	to	IN
cord-007444-c9vu8ako	269	44	the	the	DT
cord-007444-c9vu8ako	269	45	ED	ED	NNP
cord-007444-c9vu8ako	269	46	within	within	IN
cord-007444-c9vu8ako	269	47	48	48	CD
cord-007444-c9vu8ako	269	48	hours	hour	NNS
cord-007444-c9vu8ako	269	49	is	be	VBZ
cord-007444-c9vu8ako	269	50	significantly	significantly	RB
cord-007444-c9vu8ako	269	51	reduced	reduce	VBN
cord-007444-c9vu8ako	269	52	if	if	IN
cord-007444-c9vu8ako	269	53	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	269	54	are	be	VBP
cord-007444-c9vu8ako	269	55	prescribed.82	prescribed.82	JJ
cord-007444-c9vu8ako	269	56	Corticosteroids	Corticosteroids	NNPS
cord-007444-c9vu8ako	269	57	are	be	VBP
cord-007444-c9vu8ako	269	58	often	often	RB
cord-007444-c9vu8ako	269	59	given	give	VBN
cord-007444-c9vu8ako	269	60	initially	initially	RB
cord-007444-c9vu8ako	269	61	by	by	IN
cord-007444-c9vu8ako	269	62	ED	ED	NNP
cord-007444-c9vu8ako	269	63	physicians	physician	NNS
cord-007444-c9vu8ako	269	64	and	and	CC
cord-007444-c9vu8ako	269	65	several	several	JJ
cord-007444-c9vu8ako	269	66	trials	trial	NNS
cord-007444-c9vu8ako	269	67	have	have	VBP
cord-007444-c9vu8ako	269	68	examined	examine	VBN
cord-007444-c9vu8ako	269	69	this	this	DT
cord-007444-c9vu8ako	269	70	practice.2z	practice.2z	NN
cord-007444-c9vu8ako	269	71	,	,	,
cord-007444-c9vu8ako	269	72	Emerman	Emerman	NNP
cord-007444-c9vu8ako	269	73	et	et	NNP
cord-007444-c9vu8ako	269	74	a143	a143	NNP
cord-007444-c9vu8ako	269	75	studied	study	VBD
cord-007444-c9vu8ako	269	76	the	the	DT
cord-007444-c9vu8ako	269	77	effect	effect	NN
cord-007444-c9vu8ako	269	78	of	of	IN
cord-007444-c9vu8ako	269	79	a	a	DT
cord-007444-c9vu8ako	269	80	single	single	JJ
cord-007444-c9vu8ako	269	81	dose	dose	NN
cord-007444-c9vu8ako	269	82	of	of	IN
cord-007444-c9vu8ako	269	83	methylprednisolone	methylprednisolone	NN
cord-007444-c9vu8ako	269	84	(	(	-LRB-
cord-007444-c9vu8ako	269	85	100	100	CD
cord-007444-c9vu8ako	269	86	mg	mg	NNS
cord-007444-c9vu8ako	269	87	intravenously	intravenously	RB
cord-007444-c9vu8ako	269	88	[	[	-LRB-
cord-007444-c9vu8ako	269	89	IV	IV	NNP
cord-007444-c9vu8ako	269	90	]	]	-RRB-
cord-007444-c9vu8ako	269	91	)	)	-RRB-
cord-007444-c9vu8ako	269	92	upon	upon	IN
cord-007444-c9vu8ako	269	93	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	269	94	function	function	NN
cord-007444-c9vu8ako	269	95	and	and	CC
cord-007444-c9vu8ako	269	96	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	269	97	rates	rate	NNS
cord-007444-c9vu8ako	269	98	for	for	IN
cord-007444-c9vu8ako	269	99	98	98	CD
cord-007444-c9vu8ako	269	100	patients	patient	NNS
cord-007444-c9vu8ako	269	101	in	in	IN
cord-007444-c9vu8ako	269	102	the	the	DT
cord-007444-c9vu8ako	269	103	ED	ED	NNP
cord-007444-c9vu8ako	269	104	with	with	IN
cord-007444-c9vu8ako	269	105	COPD	COPD	NNP
cord-007444-c9vu8ako	269	106	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	269	107	.	.	.
cord-007444-c9vu8ako	270	1	They	-PRON-	PRP
cord-007444-c9vu8ako	270	2	failed	fail	VBD
cord-007444-c9vu8ako	270	3	to	to	TO
cord-007444-c9vu8ako	270	4	show	show	VB
cord-007444-c9vu8ako	270	5	any	any	DT
cord-007444-c9vu8ako	270	6	improvement	improvement	NN
cord-007444-c9vu8ako	270	7	in	in	IN
cord-007444-c9vu8ako	270	8	spirometry	spirometry	NN
cord-007444-c9vu8ako	270	9	or	or	CC
cord-007444-c9vu8ako	270	10	decrease	decrease	VB
cord-007444-c9vu8ako	270	11	in	in	IN
cord-007444-c9vu8ako	270	12	the	the	DT
cord-007444-c9vu8ako	270	13	rate	rate	NN
cord-007444-c9vu8ako	270	14	of	of	IN
cord-007444-c9vu8ako	270	15	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	270	16	.	.	.
cord-007444-c9vu8ako	271	1	Patients	patient	NNS
cord-007444-c9vu8ako	271	2	were	be	VBD
cord-007444-c9vu8ako	271	3	treated	treat	VBN
cord-007444-c9vu8ako	271	4	for	for	IN
cord-007444-c9vu8ako	271	5	approximately	approximately	RB
cord-007444-c9vu8ako	271	6	4.5	4.5	CD
cord-007444-c9vu8ako	271	7	hours	hour	NNS
cord-007444-c9vu8ako	271	8	and	and	CC
cord-007444-c9vu8ako	271	9	the	the	DT
cord-007444-c9vu8ako	271	10	single	single	JJ
cord-007444-c9vu8ako	271	11	steroid	steroid	NN
cord-007444-c9vu8ako	271	12	dose	dose	NN
cord-007444-c9vu8ako	271	13	and	and	CC
cord-007444-c9vu8ako	271	14	short	short	JJ
cord-007444-c9vu8ako	271	15	period	period	NN
cord-007444-c9vu8ako	271	16	of	of	IN
cord-007444-c9vu8ako	271	17	observation	observation	NN
cord-007444-c9vu8ako	271	18	,	,	,
cord-007444-c9vu8ako	271	19	however	however	RB
cord-007444-c9vu8ako	271	20	,	,	,
cord-007444-c9vu8ako	271	21	have	have	VBP
cord-007444-c9vu8ako	271	22	been	be	VBN
cord-007444-c9vu8ako	271	23	postulated	postulate	VBN
cord-007444-c9vu8ako	271	24	to	to	TO
cord-007444-c9vu8ako	271	25	account	account	VB
cord-007444-c9vu8ako	271	26	for	for	IN
cord-007444-c9vu8ako	271	27	the	the	DT
cord-007444-c9vu8ako	271	28	apparent	apparent	JJ
cord-007444-c9vu8ako	271	29	lack	lack	NN
cord-007444-c9vu8ako	271	30	of	of	IN
cord-007444-c9vu8ako	271	31	effi	effi	NNP
cord-007444-c9vu8ako	271	32	-	-	HYPH
cord-007444-c9vu8ako	271	33	cacy	cacy	NNP
cord-007444-c9vu8ako	271	34	of	of	IN
cord-007444-c9vu8ako	271	35	steroids	steroid	NNS
cord-007444-c9vu8ako	271	36	in	in	IN
cord-007444-c9vu8ako	271	37	this	this	DT
cord-007444-c9vu8ako	271	38	study.74	study.74	NN
cord-007444-c9vu8ako	272	1	More	more	RBR
cord-007444-c9vu8ako	272	2	recently	recently	RB
cord-007444-c9vu8ako	272	3	,	,	,
cord-007444-c9vu8ako	272	4	Bullard	Bullard	NNP
cord-007444-c9vu8ako	272	5	et	et	NNP
cord-007444-c9vu8ako	272	6	al	al	NNP
cord-007444-c9vu8ako	272	7	"	"	``
cord-007444-c9vu8ako	272	8	demonstrated	demonstrate	VBD
cord-007444-c9vu8ako	272	9	a	a	DT
cord-007444-c9vu8ako	272	10	beneficial	beneficial	JJ
cord-007444-c9vu8ako	272	11	effect	effect	NN
cord-007444-c9vu8ako	272	12	of	of	IN
cord-007444-c9vu8ako	272	13	steroids	steroid	NNS
cord-007444-c9vu8ako	272	14	upon	upon	IN
cord-007444-c9vu8ako	272	15	flow	flow	NN
cord-007444-c9vu8ako	272	16	rates	rate	NNS
cord-007444-c9vu8ako	272	17	as	as	RB
cord-007444-c9vu8ako	272	18	early	early	RB
cord-007444-c9vu8ako	272	19	as	as	IN
cord-007444-c9vu8ako	272	20	6	6	CD
cord-007444-c9vu8ako	272	21	hours	hour	NNS
cord-007444-c9vu8ako	272	22	after	after	IN
cord-007444-c9vu8ako	272	23	initiation	initiation	NN
cord-007444-c9vu8ako	272	24	of	of	IN
cord-007444-c9vu8ako	272	25	treatment	treatment	NN
cord-007444-c9vu8ako	272	26	.	.	.
cord-007444-c9vu8ako	273	1	In	in	IN
cord-007444-c9vu8ako	273	2	1980	1980	CD
cord-007444-c9vu8ako	273	3	,	,	,
cord-007444-c9vu8ako	273	4	AlberP	alberp	CD
cord-007444-c9vu8ako	273	5	provided	provide	VBD
cord-007444-c9vu8ako	273	6	the	the	DT
cord-007444-c9vu8ako	273	7	initial	initial	JJ
cord-007444-c9vu8ako	273	8	justification	justification	NN
cord-007444-c9vu8ako	273	9	for	for	IN
cord-007444-c9vu8ako	273	10	the	the	DT
cord-007444-c9vu8ako	273	11	routine	routine	JJ
cord-007444-c9vu8ako	273	12	use	use	NN
cord-007444-c9vu8ako	273	13	of	of	IN
cord-007444-c9vu8ako	273	14	systemic	systemic	JJ
cord-007444-c9vu8ako	273	15	steroids	steroid	NNS
cord-007444-c9vu8ako	273	16	in	in	IN
cord-007444-c9vu8ako	273	17	the	the	DT
cord-007444-c9vu8ako	273	18	care	care	NN
cord-007444-c9vu8ako	273	19	of	of	IN
cord-007444-c9vu8ako	273	20	hospitalized	hospitalize	VBN
cord-007444-c9vu8ako	273	21	patients	patient	NNS
cord-007444-c9vu8ako	273	22	with	with	IN
cord-007444-c9vu8ako	273	23	COPD	COPD	NNP
cord-007444-c9vu8ako	273	24	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	273	25	.	.	.
cord-007444-c9vu8ako	274	1	Forty	forty	CD
cord-007444-c9vu8ako	274	2	-	-	HYPH
cord-007444-c9vu8ako	274	3	four	four	CD
cord-007444-c9vu8ako	274	4	patients	patient	NNS
cord-007444-c9vu8ako	274	5	with	with	IN
cord-007444-c9vu8ako	274	6	COPD	COPD	NNP
cord-007444-c9vu8ako	274	7	and	and	CC
cord-007444-c9vu8ako	274	8	acute	acute	JJ
cord-007444-c9vu8ako	274	9	respiratory	respiratory	JJ
cord-007444-c9vu8ako	274	10	insufficiency	insufficiency	NN
cord-007444-c9vu8ako	274	11	were	be	VBD
cord-007444-c9vu8ako	274	12	randomized	randomize	VBN
cord-007444-c9vu8ako	274	13	to	to	IN
cord-007444-c9vu8ako	274	14	placebo	placebo	NN
cord-007444-c9vu8ako	274	15	or	or	CC
cord-007444-c9vu8ako	274	16	methylprednisolone	methylprednisolone	NNP
cord-007444-c9vu8ako	274	17	0.5	0.5	CD
cord-007444-c9vu8ako	275	1	mg	mg	NNP
cord-007444-c9vu8ako	275	2	/	/	SYM
cord-007444-c9vu8ako	275	3	kg	kg	CC
cord-007444-c9vu8ako	275	4	intravenously	intravenously	RB
cord-007444-c9vu8ako	275	5	every	every	DT
cord-007444-c9vu8ako	275	6	6	6	CD
cord-007444-c9vu8ako	275	7	hours	hour	NNS
cord-007444-c9vu8ako	275	8	for	for	IN
cord-007444-c9vu8ako	275	9	3	3	CD
cord-007444-c9vu8ako	275	10	days	day	NNS
cord-007444-c9vu8ako	275	11	.	.	.
cord-007444-c9vu8ako	276	1	Those	those	DT
cord-007444-c9vu8ako	276	2	treated	treat	VBN
cord-007444-c9vu8ako	276	3	with	with	IN
cord-007444-c9vu8ako	276	4	steroids	steroid	NNS
cord-007444-c9vu8ako	276	5	were	be	VBD
cord-007444-c9vu8ako	276	6	significantly	significantly	RB
cord-007444-c9vu8ako	276	7	more	more	RBR
cord-007444-c9vu8ako	276	8	likely	likely	JJ
cord-007444-c9vu8ako	276	9	to	to	TO
cord-007444-c9vu8ako	276	10	achieve	achieve	VB
cord-007444-c9vu8ako	276	11	a	a	DT
cord-007444-c9vu8ako	276	12	40	40	CD
cord-007444-c9vu8ako	276	13	%	%	NN
cord-007444-c9vu8ako	276	14	or	or	CC
cord-007444-c9vu8ako	276	15	greater	great	JJR
cord-007444-c9vu8ako	276	16	increase	increase	NN
cord-007444-c9vu8ako	276	17	in	in	IN
cord-007444-c9vu8ako	276	18	FEV	FEV	NNP
cord-007444-c9vu8ako	276	19	,	,	,
cord-007444-c9vu8ako	276	20	over	over	IN
cord-007444-c9vu8ako	276	21	their	-PRON-	PRP$
cord-007444-c9vu8ako	276	22	baseline	baseline	NN
cord-007444-c9vu8ako	276	23	.	.	.
cord-007444-c9vu8ako	277	1	This	this	DT
cord-007444-c9vu8ako	277	2	effect	effect	NN
cord-007444-c9vu8ako	277	3	was	be	VBD
cord-007444-c9vu8ako	277	4	observed	observe	VBN
cord-007444-c9vu8ako	277	5	by	by	IN
cord-007444-c9vu8ako	277	6	12	12	CD
cord-007444-c9vu8ako	277	7	hours	hour	NNS
cord-007444-c9vu8ako	277	8	following	follow	VBG
cord-007444-c9vu8ako	277	9	the	the	DT
cord-007444-c9vu8ako	277	10	start	start	NN
cord-007444-c9vu8ako	277	11	of	of	IN
cord-007444-c9vu8ako	277	12	treatment	treatment	NN
cord-007444-c9vu8ako	277	13	and	and	CC
cord-007444-c9vu8ako	277	14	persisted	persist	VBD
cord-007444-c9vu8ako	277	15	for	for	IN
cord-007444-c9vu8ako	277	16	72	72	CD
cord-007444-c9vu8ako	277	17	hours	hour	NNS
cord-007444-c9vu8ako	277	18	.	.	.
cord-007444-c9vu8ako	278	1	Corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	278	2	improved	improve	VBD
cord-007444-c9vu8ako	278	3	postbronchodilator	postbronchodilator	NN
cord-007444-c9vu8ako	278	4	lung	lung	NN
cord-007444-c9vu8ako	278	5	function	function	NN
cord-007444-c9vu8ako	278	6	more	more	JJR
cord-007444-c9vu8ako	278	7	than	than	IN
cord-007444-c9vu8ako	278	8	placebo	placebo	NN
cord-007444-c9vu8ako	278	9	but	but	CC
cord-007444-c9vu8ako	278	10	had	have	VBD
cord-007444-c9vu8ako	278	11	minimal	minimal	JJ
cord-007444-c9vu8ako	278	12	effect	effect	NN
cord-007444-c9vu8ako	278	13	upon	upon	IN
cord-007444-c9vu8ako	278	14	total	total	JJ
cord-007444-c9vu8ako	278	15	symptoms	symptom	NNS
cord-007444-c9vu8ako	278	16	in	in	IN
cord-007444-c9vu8ako	278	17	another	another	DT
cord-007444-c9vu8ako	278	18	small	small	JJ
cord-007444-c9vu8ako	278	19	trial	trial	NN
cord-007444-c9vu8ako	278	20	in	in	IN
cord-007444-c9vu8ako	278	21	which	which	WDT
cord-007444-c9vu8ako	278	22	hospitalized	hospitalize	VBN
cord-007444-c9vu8ako	278	23	patients	patient	NNS
cord-007444-c9vu8ako	278	24	were	be	VBD
cord-007444-c9vu8ako	278	25	randomized	randomize	VBN
cord-007444-c9vu8ako	278	26	to	to	TO
cord-007444-c9vu8ako	278	27	receive	receive	VB
cord-007444-c9vu8ako	278	28	placebo	placebo	NN
cord-007444-c9vu8ako	278	29	or	or	CC
cord-007444-c9vu8ako	278	30	30	30	CD
cord-007444-c9vu8ako	278	31	mg	mg	NN
cord-007444-c9vu8ako	278	32	of	of	IN
cord-007444-c9vu8ako	278	33	oral	oral	JJ
cord-007444-c9vu8ako	278	34	prednisolone	prednisolone	NN
cord-007444-c9vu8ako	278	35	for	for	IN
cord-007444-c9vu8ako	278	36	14	14	CD
cord-007444-c9vu8ako	278	37	days.%	days.%	CD
cord-007444-c9vu8ako	279	1	Although	although	IN
cord-007444-c9vu8ako	279	2	the	the	DT
cord-007444-c9vu8ako	279	3	studies	study	NNS
cord-007444-c9vu8ako	279	4	described	describe	VBN
cord-007444-c9vu8ako	279	5	have	have	VBP
cord-007444-c9vu8ako	279	6	established	establish	VBN
cord-007444-c9vu8ako	279	7	that	that	IN
cord-007444-c9vu8ako	279	8	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	279	9	significantly	significantly	RB
cord-007444-c9vu8ako	279	10	increase	increase	VBP
cord-007444-c9vu8ako	279	11	FEV	FEV	NNP
cord-007444-c9vu8ako	279	12	,	,	,
cord-007444-c9vu8ako	279	13	over	over	IN
cord-007444-c9vu8ako	279	14	the	the	DT
cord-007444-c9vu8ako	279	15	short	short	JJ
cord-007444-c9vu8ako	279	16	term	term	NN
cord-007444-c9vu8ako	279	17	,	,	,
cord-007444-c9vu8ako	279	18	no	no	DT
cord-007444-c9vu8ako	279	19	study	study	NN
cord-007444-c9vu8ako	279	20	was	be	VBD
cord-007444-c9vu8ako	279	21	explicitly	explicitly	RB
cord-007444-c9vu8ako	279	22	designed	design	VBN
cord-007444-c9vu8ako	279	23	to	to	TO
cord-007444-c9vu8ako	279	24	capture	capture	VB
cord-007444-c9vu8ako	279	25	longer	long	JJR
cord-007444-c9vu8ako	279	26	-	-	HYPH
cord-007444-c9vu8ako	279	27	term	term	NN
cord-007444-c9vu8ako	279	28	endpoints	endpoint	NNS
cord-007444-c9vu8ako	279	29	or	or	CC
cord-007444-c9vu8ako	279	30	the	the	DT
cord-007444-c9vu8ako	279	31	adverse	adverse	JJ
cord-007444-c9vu8ako	279	32	consequences	consequence	NNS
cord-007444-c9vu8ako	279	33	associated	associate	VBN
cord-007444-c9vu8ako	279	34	with	with	IN
cord-007444-c9vu8ako	279	35	steroid	steroid	NN
cord-007444-c9vu8ako	279	36	therapy	therapy	NN
cord-007444-c9vu8ako	279	37	!	!	.
cord-007444-c9vu8ako	279	38	"	"	''
cord-007444-c9vu8ako	280	1	lo2	lo2	NNP
cord-007444-c9vu8ako	280	2	Rostomlo2	Rostomlo2	NNP
cord-007444-c9vu8ako	280	3	studied	study	VBD
cord-007444-c9vu8ako	280	4	hospitalized	hospitalize	VBN
cord-007444-c9vu8ako	280	5	patients	patient	NNS
cord-007444-c9vu8ako	280	6	with	with	IN
cord-007444-c9vu8ako	280	7	AE	AE	NNP
cord-007444-c9vu8ako	280	8	-	-	HYPH
cord-007444-c9vu8ako	280	9	COPD	COPD	NNP
cord-007444-c9vu8ako	280	10	given	give	VBN
cord-007444-c9vu8ako	280	11	placebo	placebo	NN
cord-007444-c9vu8ako	280	12	or	or	CC
cord-007444-c9vu8ako	280	13	methylprednisolone	methylprednisolone	NN
cord-007444-c9vu8ako	280	14	(	(	-LRB-
cord-007444-c9vu8ako	280	15	40	40	CD
cord-007444-c9vu8ako	280	16	mg	mg	NNP
cord-007444-c9vu8ako	280	17	tapered	taper	VBD
cord-007444-c9vu8ako	280	18	to	to	IN
cord-007444-c9vu8ako	280	19	0	0	CD
cord-007444-c9vu8ako	280	20	mg	mg	NN
cord-007444-c9vu8ako	280	21	over	over	IN
cord-007444-c9vu8ako	280	22	1	1	CD
cord-007444-c9vu8ako	280	23	month	month	NN
cord-007444-c9vu8ako	280	24	)	)	-RRB-
cord-007444-c9vu8ako	280	25	and	and	CC
cord-007444-c9vu8ako	280	26	followed	follow	VBD
cord-007444-c9vu8ako	280	27	for	for	IN
cord-007444-c9vu8ako	280	28	1	1	CD
cord-007444-c9vu8ako	280	29	month	month	NN
cord-007444-c9vu8ako	280	30	after	after	IN
cord-007444-c9vu8ako	280	31	discharge	discharge	NN
cord-007444-c9vu8ako	280	32	.	.	.
cord-007444-c9vu8ako	281	1	Mean	mean	JJ
cord-007444-c9vu8ako	281	2	FEV	FEV	NNP
cord-007444-c9vu8ako	281	3	,	,	,
cord-007444-c9vu8ako	281	4	and	and	CC
cord-007444-c9vu8ako	281	5	FVC	fvc	NN
cord-007444-c9vu8ako	281	6	values	value	NNS
cord-007444-c9vu8ako	281	7	were	be	VBD
cord-007444-c9vu8ako	281	8	no	no	RB
cord-007444-c9vu8ako	281	9	different	different	JJ
cord-007444-c9vu8ako	281	10	between	between	IN
cord-007444-c9vu8ako	281	11	the	the	DT
cord-007444-c9vu8ako	281	12	treatment	treatment	NN
cord-007444-c9vu8ako	281	13	groups	group	NNS
cord-007444-c9vu8ako	281	14	at	at	IN
cord-007444-c9vu8ako	281	15	the	the	DT
cord-007444-c9vu8ako	281	16	end	end	NN
cord-007444-c9vu8ako	281	17	of	of	IN
cord-007444-c9vu8ako	281	18	the	the	DT
cord-007444-c9vu8ako	281	19	study	study	NN
cord-007444-c9vu8ako	281	20	.	.	.
cord-007444-c9vu8ako	282	1	More	more	RBR
cord-007444-c9vu8ako	282	2	recently	recently	RB
cord-007444-c9vu8ako	282	3	,	,	,
cord-007444-c9vu8ako	282	4	Niewoehner	Niewoehner	NNP
cord-007444-c9vu8ako	282	5	et	et	NNP
cord-007444-c9vu8ako	282	6	alas	alas	UH
cord-007444-c9vu8ako	282	7	published	publish	VBD
cord-007444-c9vu8ako	282	8	the	the	DT
cord-007444-c9vu8ako	282	9	important	important	JJ
cord-007444-c9vu8ako	282	10	Systemic	Systemic	NNP
cord-007444-c9vu8ako	282	11	Corticosteroids	Corticosteroids	NNPS
cord-007444-c9vu8ako	282	12	in	in	IN
cord-007444-c9vu8ako	282	13	Chronic	Chronic	NNP
cord-007444-c9vu8ako	282	14	Obstructive	obstructive	JJ
cord-007444-c9vu8ako	282	15	Pulmonary	Pulmonary	NNP
cord-007444-c9vu8ako	282	16	Disease	Disease	NNP
cord-007444-c9vu8ako	282	17	Exacerbations	Exacerbations	NNP
cord-007444-c9vu8ako	282	18	trial	trial	NN
cord-007444-c9vu8ako	282	19	.	.	.
cord-007444-c9vu8ako	283	1	They	-PRON-	PRP
cord-007444-c9vu8ako	283	2	performed	perform	VBD
cord-007444-c9vu8ako	283	3	a	a	DT
cord-007444-c9vu8ako	283	4	three	three	CD
cord-007444-c9vu8ako	283	5	-	-	HYPH
cord-007444-c9vu8ako	283	6	way	way	NN
cord-007444-c9vu8ako	283	7	randomization	randomization	NN
cord-007444-c9vu8ako	283	8	whereby	whereby	IN
cord-007444-c9vu8ako	283	9	80	80	CD
cord-007444-c9vu8ako	283	10	patients	patient	NNS
cord-007444-c9vu8ako	283	11	received	receive	VBD
cord-007444-c9vu8ako	283	12	an	an	DT
cord-007444-c9vu8ako	283	13	8-week	8-week	CD
cord-007444-c9vu8ako	283	14	course	course	NN
cord-007444-c9vu8ako	283	15	of	of	IN
cord-007444-c9vu8ako	283	16	glucocorticoids	glucocorticoid	NNS
cord-007444-c9vu8ako	283	17	,	,	,
cord-007444-c9vu8ako	283	18	80	80	CD
cord-007444-c9vu8ako	283	19	received	receive	VBD
cord-007444-c9vu8ako	283	20	a	a	DT
cord-007444-c9vu8ako	283	21	2-week	2-week	CD
cord-007444-c9vu8ako	283	22	course	course	NN
cord-007444-c9vu8ako	283	23	,	,	,
cord-007444-c9vu8ako	283	24	and	and	CC
cord-007444-c9vu8ako	283	25	111	111	CD
cord-007444-c9vu8ako	283	26	re-	re-	JJ
cord-007444-c9vu8ako	283	27	ceived	ceived	JJ
cord-007444-c9vu8ako	283	28	placebo	placebo	NN
cord-007444-c9vu8ako	283	29	.	.	.
cord-007444-c9vu8ako	284	1	Steroids	steroid	NNS
cord-007444-c9vu8ako	284	2	resulted	result	VBD
cord-007444-c9vu8ako	284	3	in	in	IN
cord-007444-c9vu8ako	284	4	faster	fast	JJR
cord-007444-c9vu8ako	284	5	recovery	recovery	NN
cord-007444-c9vu8ako	284	6	of	of	IN
cord-007444-c9vu8ako	284	7	FEV	FEV	NNP
cord-007444-c9vu8ako	284	8	,	,	,
cord-007444-c9vu8ako	284	9	and	and	CC
cord-007444-c9vu8ako	284	10	shortened	shorten	VBN
cord-007444-c9vu8ako	284	11	hospital	hospital	NN
cord-007444-c9vu8ako	284	12	stay	stay	NN
cord-007444-c9vu8ako	284	13	by	by	IN
cord-007444-c9vu8ako	284	14	1	1	CD
cord-007444-c9vu8ako	284	15	day	day	NN
cord-007444-c9vu8ako	284	16	(	(	-LRB-
cord-007444-c9vu8ako	284	17	P	p	NN
cord-007444-c9vu8ako	284	18	<	<	XX
cord-007444-c9vu8ako	284	19	0.05	0.05	CD
cord-007444-c9vu8ako	284	20	)	)	-RRB-
cord-007444-c9vu8ako	284	21	.	.	.
cord-007444-c9vu8ako	285	1	At	at	IN
cord-007444-c9vu8ako	285	2	both	both	DT
cord-007444-c9vu8ako	285	3	30	30	CD
cord-007444-c9vu8ako	285	4	and	and	CC
cord-007444-c9vu8ako	285	5	90	90	CD
cord-007444-c9vu8ako	285	6	days	day	NNS
cord-007444-c9vu8ako	285	7	,	,	,
cord-007444-c9vu8ako	285	8	steroid	steroid	NN
cord-007444-c9vu8ako	285	9	therapy	therapy	NN
cord-007444-c9vu8ako	285	10	reduced	reduce	VBN
cord-007444-c9vu8ako	285	11	treatment	treatment	NN
cord-007444-c9vu8ako	285	12	failures	failure	NNS
cord-007444-c9vu8ako	285	13	(	(	-LRB-
cord-007444-c9vu8ako	285	14	defined	define	VBN
cord-007444-c9vu8ako	285	15	as	as	IN
cord-007444-c9vu8ako	285	16	death	death	NN
cord-007444-c9vu8ako	285	17	from	from	IN
cord-007444-c9vu8ako	285	18	any	any	DT
cord-007444-c9vu8ako	285	19	cause	cause	NN
cord-007444-c9vu8ako	285	20	,	,	,
cord-007444-c9vu8ako	285	21	need	need	VBP
cord-007444-c9vu8ako	285	22	for	for	IN
cord-007444-c9vu8ako	285	23	intubation	intubation	NN
cord-007444-c9vu8ako	285	24	,	,	,
cord-007444-c9vu8ako	285	25	readmission	readmission	NN
cord-007444-c9vu8ako	285	26	,	,	,
cord-007444-c9vu8ako	285	27	or	or	CC
cord-007444-c9vu8ako	285	28	intensification	intensification	NN
cord-007444-c9vu8ako	285	29	of	of	IN
cord-007444-c9vu8ako	285	30	drug	drug	NN
cord-007444-c9vu8ako	285	31	therapy	therapy	NN
cord-007444-c9vu8ako	285	32	)	)	-RRB-
cord-007444-c9vu8ako	285	33	by	by	IN
cord-007444-c9vu8ako	285	34	approximately	approximately	RB
cord-007444-c9vu8ako	285	35	10	10	CD
cord-007444-c9vu8ako	285	36	%	%	NN
cord-007444-c9vu8ako	285	37	.	.	.
cord-007444-c9vu8ako	286	1	There	there	EX
cord-007444-c9vu8ako	286	2	was	be	VBD
cord-007444-c9vu8ako	286	3	no	no	DT
cord-007444-c9vu8ako	286	4	difference	difference	NN
cord-007444-c9vu8ako	286	5	between	between	IN
cord-007444-c9vu8ako	286	6	2	2	CD
cord-007444-c9vu8ako	286	7	and	and	CC
cord-007444-c9vu8ako	286	8	8	8	CD
cord-007444-c9vu8ako	286	9	weeks	week	NNS
cord-007444-c9vu8ako	286	10	of	of	IN
cord-007444-c9vu8ako	286	11	treatment	treatment	NN
cord-007444-c9vu8ako	286	12	with	with	IN
cord-007444-c9vu8ako	286	13	respect	respect	NN
cord-007444-c9vu8ako	286	14	to	to	IN
cord-007444-c9vu8ako	286	15	spirometry	spirometry	NN
cord-007444-c9vu8ako	286	16	or	or	CC
cord-007444-c9vu8ako	286	17	treatment	treatment	NN
cord-007444-c9vu8ako	286	18	failure	failure	NN
cord-007444-c9vu8ako	286	19	rates	rate	NNS
cord-007444-c9vu8ako	286	20	,	,	,
cord-007444-c9vu8ako	286	21	however	however	RB
cord-007444-c9vu8ako	286	22	.	.	.
cord-007444-c9vu8ako	287	1	The	the	DT
cord-007444-c9vu8ako	287	2	dose	dose	NN
cord-007444-c9vu8ako	287	3	of	of	IN
cord-007444-c9vu8ako	287	4	methylprednisolone	methylprednisolone	NN
cord-007444-c9vu8ako	287	5	was	be	VBD
cord-007444-c9vu8ako	287	6	high	high	JJ
cord-007444-c9vu8ako	287	7	(	(	-LRB-
cord-007444-c9vu8ako	287	8	125	125	CD
cord-007444-c9vu8ako	287	9	mg	mg	NN
cord-007444-c9vu8ako	287	10	every	every	DT
cord-007444-c9vu8ako	287	11	6	6	CD
cord-007444-c9vu8ako	287	12	hours	hour	NNS
cord-007444-c9vu8ako	287	13	for	for	IN
cord-007444-c9vu8ako	287	14	3	3	CD
cord-007444-c9vu8ako	287	15	days	day	NNS
cord-007444-c9vu8ako	287	16	)	)	-RRB-
cord-007444-c9vu8ako	287	17	and	and	CC
cord-007444-c9vu8ako	287	18	resulted	result	VBD
cord-007444-c9vu8ako	287	19	in	in	IN
cord-007444-c9vu8ako	287	20	significantly	significantly	RB
cord-007444-c9vu8ako	287	21	more	more	JJR
cord-007444-c9vu8ako	287	22	hyperglycemia	hyperglycemia	NN
cord-007444-c9vu8ako	287	23	and	and	CC
cord-007444-c9vu8ako	287	24	,	,	,
cord-007444-c9vu8ako	287	25	possibly	possibly	RB
cord-007444-c9vu8ako	287	26	,	,	,
cord-007444-c9vu8ako	287	27	increased	increase	VBN
cord-007444-c9vu8ako	287	28	secondary	secondary	JJ
cord-007444-c9vu8ako	287	29	infection	infection	NN
cord-007444-c9vu8ako	287	30	rates	rate	NNS
cord-007444-c9vu8ako	287	31	.	.	.
cord-007444-c9vu8ako	288	1	'	'	''
cord-007444-c9vu8ako	288	2	06	06	CD
cord-007444-c9vu8ako	289	1	In	in	IN
cord-007444-c9vu8ako	289	2	summary	summary	NN
cord-007444-c9vu8ako	289	3	,	,	,
cord-007444-c9vu8ako	289	4	the	the	DT
cord-007444-c9vu8ako	289	5	evidence	evidence	NN
cord-007444-c9vu8ako	289	6	from	from	IN
cord-007444-c9vu8ako	289	7	randomized	randomized	JJ
cord-007444-c9vu8ako	289	8	,	,	,
cord-007444-c9vu8ako	289	9	controlled	control	VBN
cord-007444-c9vu8ako	289	10	trials	trial	NNS
cord-007444-c9vu8ako	289	11	supports	support	VBZ
cord-007444-c9vu8ako	289	12	the	the	DT
cord-007444-c9vu8ako	289	13	conclusion	conclusion	NN
cord-007444-c9vu8ako	289	14	that	that	IN
cord-007444-c9vu8ako	289	15	among	among	IN
cord-007444-c9vu8ako	289	16	patients	patient	NNS
cord-007444-c9vu8ako	289	17	with	with	IN
cord-007444-c9vu8ako	289	18	acute	acute	JJ
cord-007444-c9vu8ako	289	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	289	20	,	,	,
cord-007444-c9vu8ako	289	21	oral	oral	JJ
cord-007444-c9vu8ako	289	22	or	or	CC
cord-007444-c9vu8ako	289	23	intravenous	intravenous	JJ
cord-007444-c9vu8ako	289	24	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	289	25	significantly	significantly	RB
cord-007444-c9vu8ako	289	26	increase	increase	VBP
cord-007444-c9vu8ako	289	27	the	the	DT
cord-007444-c9vu8ako	289	28	FEV	FEV	NNP
cord-007444-c9vu8ako	289	29	,	,	,
cord-007444-c9vu8ako	289	30	for	for	IN
cord-007444-c9vu8ako	289	31	up	up	IN
cord-007444-c9vu8ako	289	32	to	to	TO
cord-007444-c9vu8ako	289	33	72	72	CD
cord-007444-c9vu8ako	289	34	hours	hour	NNS
cord-007444-c9vu8ako	289	35	and	and	CC
cord-007444-c9vu8ako	289	36	likely	likely	RB
cord-007444-c9vu8ako	289	37	reduce	reduce	VB
cord-007444-c9vu8ako	289	38	the	the	DT
cord-007444-c9vu8ako	289	39	risk	risk	NN
cord-007444-c9vu8ako	289	40	for	for	IN
cord-007444-c9vu8ako	289	41	treatment	treatment	NN
cord-007444-c9vu8ako	289	42	failure	failure	NN
cord-007444-c9vu8ako	289	43	.	.	.
cord-007444-c9vu8ako	290	1	There	there	EX
cord-007444-c9vu8ako	290	2	is	be	VBZ
cord-007444-c9vu8ako	290	3	no	no	DT
cord-007444-c9vu8ako	290	4	proved	prove	VBN
cord-007444-c9vu8ako	290	5	benefit	benefit	NN
cord-007444-c9vu8ako	290	6	for	for	IN
cord-007444-c9vu8ako	290	7	treatment	treatment	NN
cord-007444-c9vu8ako	290	8	longer	long	RBR
cord-007444-c9vu8ako	290	9	than	than	IN
cord-007444-c9vu8ako	290	10	2	2	CD
cord-007444-c9vu8ako	290	11	weeks	week	NNS
cord-007444-c9vu8ako	290	12	.	.	.
cord-007444-c9vu8ako	291	1	Hyperglycemia	hyperglycemia	NN
cord-007444-c9vu8ako	291	2	is	be	VBZ
cord-007444-c9vu8ako	291	3	the	the	DT
cord-007444-c9vu8ako	291	4	most	most	RBS
cord-007444-c9vu8ako	291	5	common	common	JJ
cord-007444-c9vu8ako	291	6	short	short	JJ
cord-007444-c9vu8ako	291	7	-	-	HYPH
cord-007444-c9vu8ako	291	8	term	term	NN
cord-007444-c9vu8ako	291	9	complication	complication	NN
cord-007444-c9vu8ako	291	10	of	of	IN
cord-007444-c9vu8ako	291	11	steroid	steroid	NN
cord-007444-c9vu8ako	291	12	treatment	treatment	NN
cord-007444-c9vu8ako	291	13	.	.	.
cord-007444-c9vu8ako	292	1	As	as	IN
cord-007444-c9vu8ako	292	2	further	further	JJ
cord-007444-c9vu8ako	292	3	studies	study	NNS
cord-007444-c9vu8ako	292	4	become	become	VBP
cord-007444-c9vu8ako	292	5	available	available	JJ
cord-007444-c9vu8ako	292	6	,	,	,
cord-007444-c9vu8ako	292	7	it	-PRON-	PRP
cord-007444-c9vu8ako	292	8	will	will	MD
cord-007444-c9vu8ako	292	9	be	be	VB
cord-007444-c9vu8ako	292	10	possible	possible	JJ
cord-007444-c9vu8ako	292	11	to	to	TO
cord-007444-c9vu8ako	292	12	better	better	RB
cord-007444-c9vu8ako	292	13	understand	understand	VB
cord-007444-c9vu8ako	292	14	the	the	DT
cord-007444-c9vu8ako	292	15	risk	risk	NN
cord-007444-c9vu8ako	292	16	-	-	HYPH
cord-007444-c9vu8ako	292	17	benefit	benefit	NN
cord-007444-c9vu8ako	292	18	ratio	ratio	NN
cord-007444-c9vu8ako	292	19	for	for	IN
cord-007444-c9vu8ako	292	20	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	292	21	and	and	CC
cord-007444-c9vu8ako	292	22	,	,	,
cord-007444-c9vu8ako	292	23	through	through	IN
cord-007444-c9vu8ako	292	24	meta	meta	NNP
cord-007444-c9vu8ako	292	25	-	-	HYPH
cord-007444-c9vu8ako	292	26	analysis	analysis	NNP
cord-007444-c9vu8ako	292	27	,	,	,
cord-007444-c9vu8ako	292	28	to	to	TO
cord-007444-c9vu8ako	292	29	better	better	RB
cord-007444-c9vu8ako	292	30	define	define	VB
cord-007444-c9vu8ako	292	31	the	the	DT
cord-007444-c9vu8ako	292	32	optimum	optimum	JJ
cord-007444-c9vu8ako	292	33	dose	dose	NN
cord-007444-c9vu8ako	292	34	and	and	CC
cord-007444-c9vu8ako	292	35	duration	duration	NN
cord-007444-c9vu8ako	292	36	of	of	IN
cord-007444-c9vu8ako	292	37	therapy.136	therapy.136	CD
cord-007444-c9vu8ako	293	1	It	-PRON-	PRP
cord-007444-c9vu8ako	293	2	is	be	VBZ
cord-007444-c9vu8ako	293	3	also	also	RB
cord-007444-c9vu8ako	293	4	important	important	JJ
cord-007444-c9vu8ako	293	5	to	to	TO
cord-007444-c9vu8ako	293	6	investigate	investigate	VB
cord-007444-c9vu8ako	293	7	the	the	DT
cord-007444-c9vu8ako	293	8	long	long	JJ
cord-007444-c9vu8ako	293	9	-	-	HYPH
cord-007444-c9vu8ako	293	10	term	term	NN
cord-007444-c9vu8ako	293	11	risk	risk	NN
cord-007444-c9vu8ako	293	12	for	for	IN
cord-007444-c9vu8ako	293	13	adverse	adverse	JJ
cord-007444-c9vu8ako	293	14	effects	effect	NNS
cord-007444-c9vu8ako	293	15	of	of	IN
cord-007444-c9vu8ako	293	16	intermittent	intermittent	JJ
cord-007444-c9vu8ako	293	17	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	293	18	in	in	IN
cord-007444-c9vu8ako	293	19	patients	patient	NNS
cord-007444-c9vu8ako	293	20	who	who	WP
cord-007444-c9vu8ako	293	21	require	require	VBP
cord-007444-c9vu8ako	293	22	them	-PRON-	PRP
cord-007444-c9vu8ako	293	23	for	for	IN
cord-007444-c9vu8ako	293	24	recurrent	recurrent	JJ
cord-007444-c9vu8ako	293	25	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	293	26	over	over	IN
cord-007444-c9vu8ako	293	27	many	many	JJ
cord-007444-c9vu8ako	293	28	years	year	NNS
cord-007444-c9vu8ako	293	29	time	time	NN
cord-007444-c9vu8ako	293	30	.	.	.
cord-007444-c9vu8ako	294	1	Noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	294	2	positive	positive	JJ
cord-007444-c9vu8ako	294	3	-	-	HYPH
cord-007444-c9vu8ako	294	4	pressure	pressure	NN
cord-007444-c9vu8ako	294	5	ventilation	ventilation	NN
cord-007444-c9vu8ako	294	6	(	(	-LRB-
cord-007444-c9vu8ako	294	7	NPPV	NPPV	NNP
cord-007444-c9vu8ako	294	8	)	)	-RRB-
cord-007444-c9vu8ako	294	9	is	be	VBZ
cord-007444-c9vu8ako	294	10	arguably	arguably	RB
cord-007444-c9vu8ako	294	11	the	the	DT
cord-007444-c9vu8ako	294	12	most	most	RBS
cord-007444-c9vu8ako	294	13	significant	significant	JJ
cord-007444-c9vu8ako	294	14	recent	recent	JJ
cord-007444-c9vu8ako	294	15	advance	advance	NN
cord-007444-c9vu8ako	294	16	in	in	IN
cord-007444-c9vu8ako	294	17	the	the	DT
cord-007444-c9vu8ako	294	18	care	care	NN
cord-007444-c9vu8ako	294	19	of	of	IN
cord-007444-c9vu8ako	294	20	patients	patient	NNS
cord-007444-c9vu8ako	294	21	with	with	IN
cord-007444-c9vu8ako	294	22	COPD	COPD	NNP
cord-007444-c9vu8ako	294	23	with	with	IN
cord-007444-c9vu8ako	294	24	acute	acute	JJ
cord-007444-c9vu8ako	294	25	respiratory	respiratory	JJ
cord-007444-c9vu8ako	294	26	failure	failure	NN
cord-007444-c9vu8ako	294	27	.	.	.
cord-007444-c9vu8ako	295	1	It	-PRON-	PRP
cord-007444-c9vu8ako	295	2	avoids	avoid	VBZ
cord-007444-c9vu8ako	295	3	the	the	DT
cord-007444-c9vu8ako	295	4	complications	complication	NNS
cord-007444-c9vu8ako	295	5	of	of	IN
cord-007444-c9vu8ako	295	6	endotracheal	endotracheal	JJ
cord-007444-c9vu8ako	295	7	intubation	intubation	NN
cord-007444-c9vu8ako	295	8	and	and	CC
cord-007444-c9vu8ako	295	9	preserves	preserve	VBZ
cord-007444-c9vu8ako	295	10	airway	airway	NN
cord-007444-c9vu8ako	295	11	defense	defense	NN
cord-007444-c9vu8ako	295	12	mechanisms	mechanism	NNS
cord-007444-c9vu8ako	295	13	while	while	IN
cord-007444-c9vu8ako	295	14	allowing	allow	VBG
cord-007444-c9vu8ako	295	15	patients	patient	NNS
cord-007444-c9vu8ako	295	16	to	to	TO
cord-007444-c9vu8ako	295	17	eat	eat	VB
cord-007444-c9vu8ako	295	18	,	,	,
cord-007444-c9vu8ako	295	19	speak	speak	VB
cord-007444-c9vu8ako	295	20	,	,	,
cord-007444-c9vu8ako	295	21	and	and	CC
cord-007444-c9vu8ako	295	22	expectorate	expectorate	VBP
cord-007444-c9vu8ako	295	23	secretions	secretion	NNS
cord-007444-c9vu8ako	295	24	.	.	.
cord-007444-c9vu8ako	296	1	Acute	acute	JJ
cord-007444-c9vu8ako	296	2	respira	respira	JJ
cord-007444-c9vu8ako	296	3	-	-	HYPH
cord-007444-c9vu8ako	296	4	tory	tory	JJ
cord-007444-c9vu8ako	296	5	failure	failure	NN
cord-007444-c9vu8ako	296	6	in	in	IN
cord-007444-c9vu8ako	296	7	COPD	COPD	NNP
cord-007444-c9vu8ako	296	8	is	be	VBZ
cord-007444-c9vu8ako	296	9	often	often	RB
cord-007444-c9vu8ako	296	10	characterized	characterize	VBN
cord-007444-c9vu8ako	296	11	by	by	IN
cord-007444-c9vu8ako	296	12	a	a	DT
cord-007444-c9vu8ako	296	13	vicious	vicious	JJ
cord-007444-c9vu8ako	296	14	circle	circle	NN
cord-007444-c9vu8ako	296	15	wherein	wherein	WRB
cord-007444-c9vu8ako	296	16	the	the	DT
cord-007444-c9vu8ako	296	17	respiratory	respiratory	JJ
cord-007444-c9vu8ako	296	18	muscles	muscle	NNS
cord-007444-c9vu8ako	296	19	must	must	MD
cord-007444-c9vu8ako	296	20	meet	meet	VB
cord-007444-c9vu8ako	296	21	ever	ever	RB
cord-007444-c9vu8ako	296	22	-	-	HYPH
cord-007444-c9vu8ako	296	23	increasing	increase	VBG
cord-007444-c9vu8ako	296	24	ventilatory	ventilatory	JJ
cord-007444-c9vu8ako	296	25	demands	demand	NNS
cord-007444-c9vu8ako	296	26	under	under	IN
cord-007444-c9vu8ako	296	27	conditions	condition	NNS
cord-007444-c9vu8ako	296	28	of	of	IN
cord-007444-c9vu8ako	296	29	worsening	worsen	VBG
cord-007444-c9vu8ako	296	30	hypoxemia	hypoxemia	NN
cord-007444-c9vu8ako	296	31	,	,	,
cord-007444-c9vu8ako	296	32	hypercapnia	hypercapnia	NN
cord-007444-c9vu8ako	296	33	,	,	,
cord-007444-c9vu8ako	296	34	and	and	CC
cord-007444-c9vu8ako	296	35	acidosis	acidosis	NN
cord-007444-c9vu8ako	296	36	.	.	.
cord-007444-c9vu8ako	297	1	When	when	WRB
cord-007444-c9vu8ako	297	2	the	the	DT
cord-007444-c9vu8ako	297	3	increased	increase	VBN
cord-007444-c9vu8ako	297	4	metabolic	metabolic	JJ
cord-007444-c9vu8ako	297	5	requirements	requirement	NNS
cord-007444-c9vu8ako	297	6	of	of	IN
cord-007444-c9vu8ako	297	7	the	the	DT
cord-007444-c9vu8ako	297	8	respiratory	respiratory	JJ
cord-007444-c9vu8ako	297	9	muscles	muscle	NNS
cord-007444-c9vu8ako	297	10	can	can	MD
cord-007444-c9vu8ako	297	11	not	not	RB
cord-007444-c9vu8ako	297	12	be	be	VB
cord-007444-c9vu8ako	297	13	matched	match	VBN
cord-007444-c9vu8ako	297	14	by	by	IN
cord-007444-c9vu8ako	297	15	a	a	DT
cord-007444-c9vu8ako	297	16	commensurate	commensurate	JJ
cord-007444-c9vu8ako	297	17	rise	rise	NN
cord-007444-c9vu8ako	297	18	in	in	IN
cord-007444-c9vu8ako	297	19	the	the	DT
cord-007444-c9vu8ako	297	20	cardiac	cardiac	JJ
cord-007444-c9vu8ako	297	21	output	output	NN
cord-007444-c9vu8ako	297	22	,	,	,
cord-007444-c9vu8ako	297	23	further	further	JJ
cord-007444-c9vu8ako	297	24	acidosis	acidosis	NN
cord-007444-c9vu8ako	297	25	and	and	CC
cord-007444-c9vu8ako	297	26	muscle	muscle	NN
cord-007444-c9vu8ako	297	27	fatigue	fatigue	NN
cord-007444-c9vu8ako	297	28	ensue	ensue	NN
cord-007444-c9vu8ako	297	29	.	.	.
cord-007444-c9vu8ako	298	1	By	by	IN
cord-007444-c9vu8ako	298	2	allowing	allow	VBG
cord-007444-c9vu8ako	298	3	the	the	DT
cord-007444-c9vu8ako	298	4	muscles	muscle	NNS
cord-007444-c9vu8ako	298	5	to	to	TO
cord-007444-c9vu8ako	298	6	rest	rest	VB
cord-007444-c9vu8ako	298	7	,	,	,
cord-007444-c9vu8ako	298	8	NPPV	NPPV	NNP
cord-007444-c9vu8ako	298	9	interrupts	interrupt	VBZ
cord-007444-c9vu8ako	298	10	this	this	DT
cord-007444-c9vu8ako	298	11	process	process	NN
cord-007444-c9vu8ako	298	12	,	,	,
cord-007444-c9vu8ako	298	13	thereby	thereby	RB
cord-007444-c9vu8ako	298	14	preventing	prevent	VBG
cord-007444-c9vu8ako	298	15	respiratory	respiratory	JJ
cord-007444-c9vu8ako	298	16	arrest	arrest	NN
cord-007444-c9vu8ako	298	17	and	and	CC
cord-007444-c9vu8ako	298	18	death.n	death.n	NNP
cord-007444-c9vu8ako	298	19	Table	table	NN
cord-007444-c9vu8ako	298	20	5	5	CD
cord-007444-c9vu8ako	299	1	summarizes	summarize	VBZ
cord-007444-c9vu8ako	299	2	the	the	DT
cord-007444-c9vu8ako	299	3	randomized	randomized	JJ
cord-007444-c9vu8ako	299	4	,	,	,
cord-007444-c9vu8ako	299	5	controlled	control	VBN
cord-007444-c9vu8ako	299	6	trials	trial	NNS
cord-007444-c9vu8ako	299	7	of	of	IN
cord-007444-c9vu8ako	299	8	NPPV	NPPV	NNP
cord-007444-c9vu8ako	299	9	in	in	IN
cord-007444-c9vu8ako	299	10	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	299	11	.	.	.
cord-007444-c9vu8ako	300	1	Bott	Bott	NNP
cord-007444-c9vu8ako	300	2	et	et	IN
cord-007444-c9vu8ako	300	3	all8	all8	NN
cord-007444-c9vu8ako	300	4	randomized	randomize	VBD
cord-007444-c9vu8ako	300	5	60	60	CD
cord-007444-c9vu8ako	300	6	patients	patient	NNS
cord-007444-c9vu8ako	300	7	with	with	IN
cord-007444-c9vu8ako	300	8	COPD	COPD	NNP
cord-007444-c9vu8ako	300	9	and	and	CC
cord-007444-c9vu8ako	300	10	hypoxemic	hypoxemic	JJ
cord-007444-c9vu8ako	300	11	-	-	HYPH
cord-007444-c9vu8ako	300	12	hypercarbic	hypercarbic	JJ
cord-007444-c9vu8ako	300	13	respiratory	respiratory	JJ
cord-007444-c9vu8ako	300	14	failure	failure	NN
cord-007444-c9vu8ako	300	15	to	to	IN
cord-007444-c9vu8ako	300	16	either	either	CC
cord-007444-c9vu8ako	300	17	conventional	conventional	JJ
cord-007444-c9vu8ako	300	18	treatment	treatment	NN
cord-007444-c9vu8ako	300	19	or	or	CC
cord-007444-c9vu8ako	300	20	volume	volume	NN
cord-007444-c9vu8ako	300	21	-	-	HYPH
cord-007444-c9vu8ako	300	22	cycled	cycle	VBN
cord-007444-c9vu8ako	300	23	nasal	nasal	NN
cord-007444-c9vu8ako	300	24	NPPV	NPPV	NNP
cord-007444-c9vu8ako	300	25	.	.	.
cord-007444-c9vu8ako	301	1	Patients	patient	NNS
cord-007444-c9vu8ako	301	2	in	in	IN
cord-007444-c9vu8ako	301	3	both	both	DT
cord-007444-c9vu8ako	301	4	groups	group	NNS
cord-007444-c9vu8ako	301	5	had	have	VBD
cord-007444-c9vu8ako	301	6	similar	similar	JJ
cord-007444-c9vu8ako	301	7	pretreatment	pretreatment	JJ
cord-007444-c9vu8ako	301	8	blood	blood	NN
cord-007444-c9vu8ako	301	9	gas	gas	NN
cord-007444-c9vu8ako	301	10	and	and	CC
cord-007444-c9vu8ako	301	11	spirometric	spirometric	JJ
cord-007444-c9vu8ako	301	12	abnormalities	abnormality	NNS
cord-007444-c9vu8ako	301	13	.	.	.
cord-007444-c9vu8ako	302	1	At	at	IN
cord-007444-c9vu8ako	302	2	1	1	CD
cord-007444-c9vu8ako	302	3	hour	hour	NN
cord-007444-c9vu8ako	302	4	,	,	,
cord-007444-c9vu8ako	302	5	there	there	EX
cord-007444-c9vu8ako	302	6	was	be	VBD
cord-007444-c9vu8ako	302	7	a	a	DT
cord-007444-c9vu8ako	302	8	significant	significant	JJ
cord-007444-c9vu8ako	302	9	rise	rise	NN
cord-007444-c9vu8ako	302	10	in	in	IN
cord-007444-c9vu8ako	302	11	pH	ph	NN
cord-007444-c9vu8ako	302	12	and	and	CC
cord-007444-c9vu8ako	302	13	drop	drop	VB
cord-007444-c9vu8ako	302	14	in	in	IN
cord-007444-c9vu8ako	303	1	Paco2	paco2	JJ
cord-007444-c9vu8ako	303	2	in	in	IN
cord-007444-c9vu8ako	303	3	the	the	DT
cord-007444-c9vu8ako	303	4	NPPV	NPPV	NNP
cord-007444-c9vu8ako	303	5	group	group	NN
cord-007444-c9vu8ako	304	1	compared	compare	VBN
cord-007444-c9vu8ako	304	2	with	with	IN
cord-007444-c9vu8ako	304	3	conventional	conventional	JJ
cord-007444-c9vu8ako	304	4	treatment	treatment	NN
cord-007444-c9vu8ako	304	5	.	.	.
cord-007444-c9vu8ako	305	1	NPPV	NPPV	NNP
cord-007444-c9vu8ako	305	2	also	also	RB
cord-007444-c9vu8ako	305	3	resulted	result	VBD
cord-007444-c9vu8ako	305	4	in	in	IN
cord-007444-c9vu8ako	305	5	significantly	significantly	RB
cord-007444-c9vu8ako	305	6	less	less	JJR
cord-007444-c9vu8ako	305	7	breathlessness	breathlessness	NN
cord-007444-c9vu8ako	305	8	by	by	IN
cord-007444-c9vu8ako	305	9	day	day	NN
cord-007444-c9vu8ako	305	10	3	3	CD
cord-007444-c9vu8ako	305	11	.	.	.
cord-007444-c9vu8ako	306	1	Most	most	RBS
cord-007444-c9vu8ako	306	2	importantly	importantly	RB
cord-007444-c9vu8ako	306	3	,	,	,
cord-007444-c9vu8ako	306	4	however	however	RB
cord-007444-c9vu8ako	306	5	,	,	,
cord-007444-c9vu8ako	306	6	intention	intention	NN
cord-007444-c9vu8ako	306	7	-	-	HYPH
cord-007444-c9vu8ako	306	8	to	to	IN
cord-007444-c9vu8ako	306	9	-	-	HYPH
cord-007444-c9vu8ako	306	10	treat	treat	VB
cord-007444-c9vu8ako	306	11	analysis	analysis	NN
cord-007444-c9vu8ako	306	12	revealed	reveal	VBD
cord-007444-c9vu8ako	306	13	a	a	DT
cord-007444-c9vu8ako	306	14	trend	trend	NN
cord-007444-c9vu8ako	306	15	toward	toward	IN
cord-007444-c9vu8ako	306	16	lower	low	JJR
cord-007444-c9vu8ako	306	17	30-day	30-day	CD
cord-007444-c9vu8ako	306	18	mortality	mortality	NN
cord-007444-c9vu8ako	306	19	in	in	IN
cord-007444-c9vu8ako	306	20	the	the	DT
cord-007444-c9vu8ako	306	21	NPPV	NPPV	NNP
cord-007444-c9vu8ako	306	22	group	group	NN
cord-007444-c9vu8ako	306	23	(	(	-LRB-
cord-007444-c9vu8ako	306	24	3	3	CD
cord-007444-c9vu8ako	306	25	/	/	SYM
cord-007444-c9vu8ako	306	26	30	30	CD
cord-007444-c9vu8ako	306	27	versus	versus	IN
cord-007444-c9vu8ako	306	28	9	9	CD
cord-007444-c9vu8ako	306	29	/	/	SYM
cord-007444-c9vu8ako	306	30	30	30	CD
cord-007444-c9vu8ako	306	31	,	,	,
cord-007444-c9vu8ako	306	32	relative	relative	JJ
cord-007444-c9vu8ako	306	33	risk	risk	NN
cord-007444-c9vu8ako	306	34	=	=	SYM
cord-007444-c9vu8ako	306	35	0.33	0.33	CD
cord-007444-c9vu8ako	306	36	,	,	,
cord-007444-c9vu8ako	306	37	95	95	CD
cord-007444-c9vu8ako	306	38	%	%	NN
cord-007444-c9vu8ako	306	39	CI	CI	NNP
cord-007444-c9vu8ako	306	40	0.1	0.1	CD
cord-007444-c9vu8ako	306	41	-	-	HYPH
cord-007444-c9vu8ako	306	42	1.11	1.11	CD
cord-007444-c9vu8ako	306	43	,	,	,
cord-007444-c9vu8ako	306	44	P	p	NN
cord-007444-c9vu8ako	306	45	=	=	SYM
cord-007444-c9vu8ako	306	46	ns	ns	NN
cord-007444-c9vu8ako	306	47	)	)	-RRB-
cord-007444-c9vu8ako	306	48	.	.	.
cord-007444-c9vu8ako	307	1	This	this	DT
cord-007444-c9vu8ako	307	2	effect	effect	NN
cord-007444-c9vu8ako	307	3	became	become	VBD
cord-007444-c9vu8ako	307	4	significant	significant	JJ
cord-007444-c9vu8ako	307	5	after	after	IN
cord-007444-c9vu8ako	307	6	excluding	exclude	VBG
cord-007444-c9vu8ako	307	7	the	the	DT
cord-007444-c9vu8ako	307	8	four	four	CD
cord-007444-c9vu8ako	307	9	patients	patient	NNS
cord-007444-c9vu8ako	307	10	randomized	randomize	VBN
cord-007444-c9vu8ako	307	11	to	to	IN
cord-007444-c9vu8ako	307	12	NPPV	NPPV	NNP
cord-007444-c9vu8ako	307	13	who	who	WP
cord-007444-c9vu8ako	307	14	did	do	VBD
cord-007444-c9vu8ako	307	15	not	not	RB
cord-007444-c9vu8ako	307	16	receive	receive	VB
cord-007444-c9vu8ako	307	17	it	-PRON-	PRP
cord-007444-c9vu8ako	307	18	(	(	-LRB-
cord-007444-c9vu8ako	307	19	two	two	CD
cord-007444-c9vu8ako	307	20	were	be	VBD
cord-007444-c9vu8ako	307	21	confused	confused	JJ
cord-007444-c9vu8ako	307	22	,	,	,
cord-007444-c9vu8ako	307	23	one	one	CD
cord-007444-c9vu8ako	307	24	was	be	VBD
cord-007444-c9vu8ako	307	25	unable	unable	JJ
cord-007444-c9vu8ako	307	26	to	to	TO
cord-007444-c9vu8ako	307	27	breathe	breathe	VB
cord-007444-c9vu8ako	307	28	through	through	IN
cord-007444-c9vu8ako	307	29	his	-PRON-	PRP$
cord-007444-c9vu8ako	307	30	nose	nose	NN
cord-007444-c9vu8ako	307	31	,	,	,
cord-007444-c9vu8ako	307	32	one	one	PRP
cord-007444-c9vu8ako	307	33	had	have	VBD
cord-007444-c9vu8ako	307	34	all	all	DT
cord-007444-c9vu8ako	307	35	active	active	JJ
cord-007444-c9vu8ako	307	36	treatment	treatment	NN
cord-007444-c9vu8ako	307	37	withdrawn	withdraw	VBN
cord-007444-c9vu8ako	307	38	)	)	-RRB-
cord-007444-c9vu8ako	307	39	.	.	.
cord-007444-c9vu8ako	308	1	None	none	NN
cord-007444-c9vu8ako	308	2	of	of	IN
cord-007444-c9vu8ako	308	3	the	the	DT
cord-007444-c9vu8ako	308	4	patients	patient	NNS
cord-007444-c9vu8ako	308	5	randomized	randomize	VBN
cord-007444-c9vu8ako	308	6	to	to	IN
cord-007444-c9vu8ako	308	7	NPPV	NPPV	NNP
cord-007444-c9vu8ako	308	8	required	require	VBN
cord-007444-c9vu8ako	308	9	intubation	intubation	NN
cord-007444-c9vu8ako	308	10	and	and	CC
cord-007444-c9vu8ako	308	11	no	no	DT
cord-007444-c9vu8ako	308	12	serious	serious	JJ
cord-007444-c9vu8ako	308	13	complications	complication	NNS
cord-007444-c9vu8ako	308	14	of	of	IN
cord-007444-c9vu8ako	308	15	NPPV	NPPV	NNP
cord-007444-c9vu8ako	308	16	were	be	VBD
cord-007444-c9vu8ako	308	17	reported	report	VBN
cord-007444-c9vu8ako	308	18	.	.	.
cord-007444-c9vu8ako	309	1	The	the	DT
cord-007444-c9vu8ako	309	2	study	study	NN
cord-007444-c9vu8ako	309	3	has	have	VBZ
cord-007444-c9vu8ako	309	4	been	be	VBN
cord-007444-c9vu8ako	309	5	criticized	criticize	VBN
cord-007444-c9vu8ako	309	6	for	for	IN
cord-007444-c9vu8ako	309	7	the	the	DT
cord-007444-c9vu8ako	309	8	lack	lack	NN
cord-007444-c9vu8ako	309	9	of	of	IN
cord-007444-c9vu8ako	309	10	standardized	standardized	JJ
cord-007444-c9vu8ako	309	11	treatment	treatment	NN
cord-007444-c9vu8ako	309	12	in	in	IN
cord-007444-c9vu8ako	309	13	both	both	DT
cord-007444-c9vu8ako	309	14	groups	group	NNS
cord-007444-c9vu8ako	309	15	and	and	CC
cord-007444-c9vu8ako	309	16	for	for	IN
cord-007444-c9vu8ako	309	17	the	the	DT
cord-007444-c9vu8ako	309	18	unusually	unusually	RB
cord-007444-c9vu8ako	309	19	high	high	JJ
cord-007444-c9vu8ako	309	20	mortality	mortality	NN
cord-007444-c9vu8ako	309	21	in	in	IN
cord-007444-c9vu8ako	309	22	the	the	DT
cord-007444-c9vu8ako	309	23	control	control	NN
cord-007444-c9vu8ako	309	24	group	group	NN
cord-007444-c9vu8ako	309	25	.	.	.
cord-007444-c9vu8ako	310	1	76	76	CD
cord-007444-c9vu8ako	310	2	Kramer	Kramer	NNP
cord-007444-c9vu8ako	310	3	et	et	NNP
cord-007444-c9vu8ako	310	4	aF5	aF5	NNP
cord-007444-c9vu8ako	310	5	investigated	investigate	VBD
cord-007444-c9vu8ako	310	6	the	the	DT
cord-007444-c9vu8ako	310	7	impact	impact	NN
cord-007444-c9vu8ako	310	8	of	of	IN
cord-007444-c9vu8ako	310	9	NPPV	NPPV	NNP
cord-007444-c9vu8ako	310	10	on	on	IN
cord-007444-c9vu8ako	310	11	need	need	NN
cord-007444-c9vu8ako	310	12	for	for	IN
cord-007444-c9vu8ako	310	13	intubation	intubation	NN
cord-007444-c9vu8ako	310	14	among	among	IN
cord-007444-c9vu8ako	310	15	31	31	CD
cord-007444-c9vu8ako	310	16	patients	patient	NNS
cord-007444-c9vu8ako	310	17	with	with	IN
cord-007444-c9vu8ako	310	18	severe	severe	JJ
cord-007444-c9vu8ako	310	19	hypercarbic	hypercarbic	JJ
cord-007444-c9vu8ako	310	20	respiratory	respiratory	JJ
cord-007444-c9vu8ako	310	21	failure	failure	NN
cord-007444-c9vu8ako	310	22	,	,	,
cord-007444-c9vu8ako	310	23	most	most	JJS
cord-007444-c9vu8ako	310	24	with	with	IN
cord-007444-c9vu8ako	310	25	COPD	COPD	NNP
cord-007444-c9vu8ako	310	26	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	310	27	.	.	.
cord-007444-c9vu8ako	311	1	Sixteen	sixteen	CD
cord-007444-c9vu8ako	311	2	patients	patient	NNS
cord-007444-c9vu8ako	311	3	(	(	-LRB-
cord-007444-c9vu8ako	311	4	11	11	CD
cord-007444-c9vu8ako	311	5	with	with	IN
cord-007444-c9vu8ako	311	6	COPD	COPD	NNP
cord-007444-c9vu8ako	311	7	)	)	-RRB-
cord-007444-c9vu8ako	311	8	were	be	VBD
cord-007444-c9vu8ako	311	9	randomized	randomize	VBN
cord-007444-c9vu8ako	311	10	to	to	IN
cord-007444-c9vu8ako	311	11	pressure	pressure	NN
cord-007444-c9vu8ako	311	12	-	-	HYPH
cord-007444-c9vu8ako	311	13	limited	limit	VBN
cord-007444-c9vu8ako	311	14	nasal	nasal	NN
cord-007444-c9vu8ako	311	15	NPPV	NPPV	NNP
cord-007444-c9vu8ako	311	16	in	in	IN
cord-007444-c9vu8ako	311	17	addition	addition	NN
cord-007444-c9vu8ako	311	18	to	to	IN
cord-007444-c9vu8ako	311	19	standard	standard	JJ
cord-007444-c9vu8ako	311	20	care	care	NN
cord-007444-c9vu8ako	311	21	and	and	CC
cord-007444-c9vu8ako	311	22	15	15	CD
cord-007444-c9vu8ako	311	23	patients	patient	NNS
cord-007444-c9vu8ako	311	24	(	(	-LRB-
cord-007444-c9vu8ako	311	25	12	12	CD
cord-007444-c9vu8ako	311	26	with	with	IN
cord-007444-c9vu8ako	311	27	COPD	COPD	NNP
cord-007444-c9vu8ako	311	28	)	)	-RRB-
cord-007444-c9vu8ako	311	29	received	receive	VBD
cord-007444-c9vu8ako	311	30	standard	standard	JJ
cord-007444-c9vu8ako	311	31	care	care	NN
cord-007444-c9vu8ako	311	32	alone	alone	RB
cord-007444-c9vu8ako	311	33	.	.	.
cord-007444-c9vu8ako	312	1	Clear	clear	VB
cord-007444-c9vu8ako	312	2	a	a	DT
cord-007444-c9vu8ako	312	3	priori	priori	FW
cord-007444-c9vu8ako	312	4	indications	indication	NNS
cord-007444-c9vu8ako	312	5	for	for	IN
cord-007444-c9vu8ako	312	6	intubation	intubation	NN
cord-007444-c9vu8ako	312	7	were	be	VBD
cord-007444-c9vu8ako	312	8	given	give	VBN
cord-007444-c9vu8ako	312	9	.	.	.
cord-007444-c9vu8ako	313	1	Significantly	significantly	RB
cord-007444-c9vu8ako	313	2	,	,	,
cord-007444-c9vu8ako	313	3	only	only	RB
cord-007444-c9vu8ako	313	4	five	five	CD
cord-007444-c9vu8ako	313	5	patients	patient	NNS
cord-007444-c9vu8ako	313	6	(	(	-LRB-
cord-007444-c9vu8ako	313	7	31	31	CD
cord-007444-c9vu8ako	313	8	%	%	NN
cord-007444-c9vu8ako	313	9	)	)	-RRB-
cord-007444-c9vu8ako	313	10	in	in	IN
cord-007444-c9vu8ako	313	11	the	the	DT
cord-007444-c9vu8ako	313	12	NPPV	NPPV	NNP
cord-007444-c9vu8ako	313	13	group	group	NN
cord-007444-c9vu8ako	313	14	required	require	VBD
cord-007444-c9vu8ako	313	15	intubation	intubation	NN
cord-007444-c9vu8ako	313	16	,	,	,
cord-007444-c9vu8ako	313	17	compared	compare	VBN
cord-007444-c9vu8ako	313	18	with	with	IN
cord-007444-c9vu8ako	313	19	11	11	CD
cord-007444-c9vu8ako	313	20	(	(	-LRB-
cord-007444-c9vu8ako	313	21	73	73	CD
cord-007444-c9vu8ako	313	22	%	%	NN
cord-007444-c9vu8ako	313	23	)	)	-RRB-
cord-007444-c9vu8ako	313	24	in	in	IN
cord-007444-c9vu8ako	313	25	the	the	DT
cord-007444-c9vu8ako	313	26	standard	standard	JJ
cord-007444-c9vu8ako	313	27	therapy	therapy	NN
cord-007444-c9vu8ako	313	28	arm	arm	NN
cord-007444-c9vu8ako	313	29	.	.	.
cord-007444-c9vu8ako	314	1	Furthermore	furthermore	RB
cord-007444-c9vu8ako	314	2	,	,	,
cord-007444-c9vu8ako	314	3	maximal	maximal	JJ
cord-007444-c9vu8ako	314	4	inspiratory	inspiratory	JJ
cord-007444-c9vu8ako	314	5	pressures	pressure	NNS
cord-007444-c9vu8ako	314	6	increased	increase	VBD
cord-007444-c9vu8ako	314	7	significantly	significantly	RB
cord-007444-c9vu8ako	314	8	in	in	IN
cord-007444-c9vu8ako	314	9	the	the	DT
cord-007444-c9vu8ako	314	10	NPPV	NPPV	NNP
cord-007444-c9vu8ako	314	11	arm	arm	NN
cord-007444-c9vu8ako	314	12	over	over	IN
cord-007444-c9vu8ako	314	13	6	6	CD
cord-007444-c9vu8ako	314	14	hours	hour	NNS
cord-007444-c9vu8ako	314	15	,	,	,
cord-007444-c9vu8ako	314	16	indicating	indicate	VBG
cord-007444-c9vu8ako	314	17	a	a	DT
cord-007444-c9vu8ako	314	18	rapid	rapid	JJ
cord-007444-c9vu8ako	314	19	reversal	reversal	NN
cord-007444-c9vu8ako	314	20	of	of	IN
cord-007444-c9vu8ako	314	21	diaphragmatic	diaphragmatic	JJ
cord-007444-c9vu8ako	314	22	fatigue	fatigue	NN
cord-007444-c9vu8ako	314	23	.	.	.
cord-007444-c9vu8ako	315	1	In	in	IN
cord-007444-c9vu8ako	315	2	contrast	contrast	NN
cord-007444-c9vu8ako	315	3	to	to	IN
cord-007444-c9vu8ako	315	4	work	work	NN
cord-007444-c9vu8ako	315	5	by	by	IN
cord-007444-c9vu8ako	315	6	Bott	Bott	NNP
cord-007444-c9vu8ako	315	7	,	,	,
cord-007444-c9vu8ako	315	8	Is	be	VBZ
cord-007444-c9vu8ako	315	9	however	however	RB
cord-007444-c9vu8ako	315	10	,	,	,
cord-007444-c9vu8ako	315	11	there	there	EX
cord-007444-c9vu8ako	315	12	were	be	VBD
cord-007444-c9vu8ako	315	13	no	no	DT
cord-007444-c9vu8ako	315	14	significant	significant	JJ
cord-007444-c9vu8ako	315	15	differences	difference	NNS
cord-007444-c9vu8ako	315	16	in	in	IN
cord-007444-c9vu8ako	315	17	Pam2	Pam2	NNP
cord-007444-c9vu8ako	315	18	between	between	IN
cord-007444-c9vu8ako	315	19	the	the	DT
cord-007444-c9vu8ako	315	20	treatment	treatment	NN
cord-007444-c9vu8ako	315	21	groups	group	NNS
cord-007444-c9vu8ako	315	22	at	at	IN
cord-007444-c9vu8ako	315	23	any	any	DT
cord-007444-c9vu8ako	315	24	time	time	NN
cord-007444-c9vu8ako	315	25	over	over	IN
cord-007444-c9vu8ako	315	26	the	the	DT
cord-007444-c9vu8ako	315	27	first	first	JJ
cord-007444-c9vu8ako	315	28	24	24	CD
cord-007444-c9vu8ako	315	29	hours	hour	NNS
cord-007444-c9vu8ako	315	30	.	.	.
cord-007444-c9vu8ako	316	1	The	the	DT
cord-007444-c9vu8ako	316	2	study	study	NN
cord-007444-c9vu8ako	316	3	was	be	VBD
cord-007444-c9vu8ako	316	4	underpowered	underpowered	JJ
cord-007444-c9vu8ako	316	5	to	to	TO
cord-007444-c9vu8ako	316	6	detect	detect	VB
cord-007444-c9vu8ako	316	7	differences	difference	NNS
cord-007444-c9vu8ako	316	8	in	in	IN
cord-007444-c9vu8ako	316	9	mortality	mortality	NN
cord-007444-c9vu8ako	316	10	.	.	.
cord-007444-c9vu8ako	317	1	A	a	DT
cord-007444-c9vu8ako	317	2	more	more	RBR
cord-007444-c9vu8ako	317	3	recent	recent	JJ
cord-007444-c9vu8ako	317	4	European	european	JJ
cord-007444-c9vu8ako	317	5	multicenter	multicenter	JJ
cord-007444-c9vu8ako	317	6	trialz1	trialz1	NN
cord-007444-c9vu8ako	317	7	randomized	randomize	VBD
cord-007444-c9vu8ako	317	8	85	85	CD
cord-007444-c9vu8ako	317	9	patients	patient	NNS
cord-007444-c9vu8ako	317	10	to	to	IN
cord-007444-c9vu8ako	317	11	standard	standard	JJ
cord-007444-c9vu8ako	317	12	therapy	therapy	NN
cord-007444-c9vu8ako	317	13	or	or	CC
cord-007444-c9vu8ako	317	14	pressure	pressure	NN
cord-007444-c9vu8ako	317	15	-	-	HYPH
cord-007444-c9vu8ako	317	16	limited	limit	VBN
cord-007444-c9vu8ako	317	17	NPPV	nppv	NN
cord-007444-c9vu8ako	317	18	by	by	IN
cord-007444-c9vu8ako	317	19	face	face	NN
cord-007444-c9vu8ako	317	20	mask	mask	NN
cord-007444-c9vu8ako	317	21	.	.	.
cord-007444-c9vu8ako	318	1	All	all	DT
cord-007444-c9vu8ako	318	2	patients	patient	NNS
cord-007444-c9vu8ako	318	3	required	require	VBD
cord-007444-c9vu8ako	318	4	admission	admission	NN
cord-007444-c9vu8ako	318	5	to	to	IN
cord-007444-c9vu8ako	318	6	an	an	DT
cord-007444-c9vu8ako	318	7	intensive	intensive	JJ
cord-007444-c9vu8ako	318	8	care	care	NN
cord-007444-c9vu8ako	318	9	unit	unit	NN
cord-007444-c9vu8ako	318	10	and	and	CC
cord-007444-c9vu8ako	318	11	were	be	VBD
cord-007444-c9vu8ako	318	12	followed	follow	VBN
cord-007444-c9vu8ako	318	13	until	until	IN
cord-007444-c9vu8ako	318	14	death	death	NN
cord-007444-c9vu8ako	318	15	or	or	CC
cord-007444-c9vu8ako	318	16	hospital	hospital	NN
cord-007444-c9vu8ako	318	17	discharge	discharge	NN
cord-007444-c9vu8ako	318	18	.	.	.
cord-007444-c9vu8ako	319	1	Noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	319	2	ventilation	ventilation	NN
cord-007444-c9vu8ako	319	3	markedly	markedly	RB
cord-007444-c9vu8ako	319	4	reduced	reduce	VBD
cord-007444-c9vu8ako	319	5	the	the	DT
cord-007444-c9vu8ako	319	6	need	need	NN
cord-007444-c9vu8ako	319	7	for	for	IN
cord-007444-c9vu8ako	319	8	intubation	intubation	NN
cord-007444-c9vu8ako	319	9	(	(	-LRB-
cord-007444-c9vu8ako	319	10	controls	control	VBZ
cord-007444-c9vu8ako	319	11	74	74	CD
cord-007444-c9vu8ako	319	12	%	%	NN
cord-007444-c9vu8ako	319	13	versus	versus	IN
cord-007444-c9vu8ako	319	14	NPPV	NPPV	NNP
cord-007444-c9vu8ako	319	15	26	26	CD
cord-007444-c9vu8ako	319	16	%	%	NN
cord-007444-c9vu8ako	319	17	)	)	-RRB-
cord-007444-c9vu8ako	319	18	.	.	.
cord-007444-c9vu8ako	320	1	Compared	compare	VBN
cord-007444-c9vu8ako	320	2	with	with	IN
cord-007444-c9vu8ako	320	3	standard	standard	JJ
cord-007444-c9vu8ako	320	4	care	care	NN
cord-007444-c9vu8ako	320	5	,	,	,
cord-007444-c9vu8ako	320	6	NPPV	NPPV	NNP
cord-007444-c9vu8ako	320	7	also	also	RB
cord-007444-c9vu8ako	320	8	significantly	significantly	RB
cord-007444-c9vu8ako	320	9	reduced	reduce	VBD
cord-007444-c9vu8ako	320	10	mortality	mortality	NN
cord-007444-c9vu8ako	320	11	(	(	-LRB-
cord-007444-c9vu8ako	320	12	9	9	CD
cord-007444-c9vu8ako	320	13	%	%	NN
cord-007444-c9vu8ako	320	14	versus	versus	IN
cord-007444-c9vu8ako	320	15	29	29	CD
cord-007444-c9vu8ako	320	16	%	%	NN
cord-007444-c9vu8ako	320	17	)	)	-RRB-
cord-007444-c9vu8ako	320	18	,	,	,
cord-007444-c9vu8ako	320	19	complication	complication	NN
cord-007444-c9vu8ako	320	20	rates	rate	NNS
cord-007444-c9vu8ako	320	21	(	(	-LRB-
cord-007444-c9vu8ako	320	22	16	16	CD
cord-007444-c9vu8ako	320	23	%	%	NN
cord-007444-c9vu8ako	320	24	versus	versus	IN
cord-007444-c9vu8ako	320	25	48	48	CD
cord-007444-c9vu8ako	320	26	%	%	NN
cord-007444-c9vu8ako	320	27	)	)	-RRB-
cord-007444-c9vu8ako	320	28	,	,	,
cord-007444-c9vu8ako	320	29	and	and	CC
cord-007444-c9vu8ako	320	30	mean	mean	JJ
cord-007444-c9vu8ako	320	31	duration	duration	NN
cord-007444-c9vu8ako	320	32	of	of	IN
cord-007444-c9vu8ako	320	33	hospital	hospital	NN
cord-007444-c9vu8ako	320	34	stay	stay	NN
cord-007444-c9vu8ako	320	35	(	(	-LRB-
cord-007444-c9vu8ako	320	36	23	23	CD
cord-007444-c9vu8ako	320	37	days	day	NNS
cord-007444-c9vu8ako	320	38	versus	versus	IN
cord-007444-c9vu8ako	320	39	35	35	CD
cord-007444-c9vu8ako	320	40	days	day	NNS
cord-007444-c9vu8ako	320	41	)	)	-RRB-
cord-007444-c9vu8ako	320	42	(	(	-LRB-
cord-007444-c9vu8ako	320	43	all	all	DT
cord-007444-c9vu8ako	320	44	P	p	NN
cord-007444-c9vu8ako	320	45	<	<	XX
cord-007444-c9vu8ako	320	46	0.05).21	0.05).21	.
cord-007444-c9vu8ako	320	47	More	more	RBR
cord-007444-c9vu8ako	320	48	recently	recently	RB
cord-007444-c9vu8ako	320	49	,	,	,
cord-007444-c9vu8ako	320	50	celikel	celikel	NNP
cord-007444-c9vu8ako	320	51	et	et	NNP
cord-007444-c9vu8ako	320	52	a130	a130	NNP
cord-007444-c9vu8ako	320	53	compared	compare	VBN
cord-007444-c9vu8ako	320	54	pressurelimited	pressurelimite	VBN
cord-007444-c9vu8ako	320	55	NPPV	NPPV	NNP
cord-007444-c9vu8ako	320	56	by	by	IN
cord-007444-c9vu8ako	320	57	face	face	NN
cord-007444-c9vu8ako	320	58	mask	mask	NN
cord-007444-c9vu8ako	320	59	with	with	IN
cord-007444-c9vu8ako	320	60	usual	usual	JJ
cord-007444-c9vu8ako	320	61	care	care	NN
cord-007444-c9vu8ako	320	62	among	among	IN
cord-007444-c9vu8ako	320	63	patients	patient	NNS
cord-007444-c9vu8ako	320	64	with	with	IN
cord-007444-c9vu8ako	320	65	moderately	moderately	RB
cord-007444-c9vu8ako	320	66	severe	severe	JJ
cord-007444-c9vu8ako	320	67	hypercarbic	hypercarbic	JJ
cord-007444-c9vu8ako	320	68	acute	acute	JJ
cord-007444-c9vu8ako	320	69	respiratory	respiratory	JJ
cord-007444-c9vu8ako	320	70	failure	failure	NN
cord-007444-c9vu8ako	320	71	and	and	CC
cord-007444-c9vu8ako	320	72	COPD	COPD	NNP
cord-007444-c9vu8ako	320	73	.	.	.
cord-007444-c9vu8ako	321	1	Noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	321	2	positive	positive	JJ
cord-007444-c9vu8ako	321	3	-	-	HYPH
cord-007444-c9vu8ako	321	4	pressure	pressure	NN
cord-007444-c9vu8ako	321	5	ventilation	ventilation	NN
cord-007444-c9vu8ako	321	6	resulted	result	VBD
cord-007444-c9vu8ako	321	7	in	in	IN
cord-007444-c9vu8ako	321	8	significantly	significantly	RB
cord-007444-c9vu8ako	321	9	fewer	few	JJR
cord-007444-c9vu8ako	321	10	treatment	treatment	NN
cord-007444-c9vu8ako	321	11	failures	failure	NNS
cord-007444-c9vu8ako	321	12	,	,	,
cord-007444-c9vu8ako	321	13	defined	define	VBN
cord-007444-c9vu8ako	321	14	as	as	IN
cord-007444-c9vu8ako	321	15	need	need	NN
cord-007444-c9vu8ako	321	16	for	for	IN
cord-007444-c9vu8ako	321	17	intubation	intubation	NN
cord-007444-c9vu8ako	321	18	in	in	IN
cord-007444-c9vu8ako	321	19	the	the	DT
cord-007444-c9vu8ako	321	20	NPPV	NPPV	NNP
cord-007444-c9vu8ako	321	21	group	group	NN
cord-007444-c9vu8ako	321	22	and	and	CC
cord-007444-c9vu8ako	321	23	need	need	NN
cord-007444-c9vu8ako	321	24	for	for	IN
cord-007444-c9vu8ako	321	25	NPPV	NPPV	NNP
cord-007444-c9vu8ako	321	26	or	or	CC
cord-007444-c9vu8ako	321	27	intubation	intubation	NN
cord-007444-c9vu8ako	321	28	in	in	IN
cord-007444-c9vu8ako	321	29	the	the	DT
cord-007444-c9vu8ako	321	30	control	control	NN
cord-007444-c9vu8ako	321	31	group	group	NN
cord-007444-c9vu8ako	321	32	.	.	.
cord-007444-c9vu8ako	322	1	Hospital	hospital	NN
cord-007444-c9vu8ako	322	2	stays	stay	NNS
cord-007444-c9vu8ako	322	3	were	be	VBD
cord-007444-c9vu8ako	322	4	significantly	significantly	RB
cord-007444-c9vu8ako	322	5	shorter	short	JJR
cord-007444-c9vu8ako	322	6	in	in	IN
cord-007444-c9vu8ako	322	7	the	the	DT
cord-007444-c9vu8ako	322	8	NPPV	NPPV	NNP
cord-007444-c9vu8ako	322	9	group	group	NN
cord-007444-c9vu8ako	322	10	.	.	.
cord-007444-c9vu8ako	323	1	In	in	IN
cord-007444-c9vu8ako	323	2	contrast	contrast	NN
cord-007444-c9vu8ako	323	3	,	,	,
cord-007444-c9vu8ako	323	4	Barb6	Barb6	NNP
cord-007444-c9vu8ako	323	5	et	et	NNP
cord-007444-c9vu8ako	323	6	al	al	NNP
cord-007444-c9vu8ako	323	7	,	,	,
cord-007444-c9vu8ako	323	8	I5	I5	NNP
cord-007444-c9vu8ako	323	9	however	however	RB
cord-007444-c9vu8ako	323	10	,	,	,
cord-007444-c9vu8ako	323	11	were	be	VBD
cord-007444-c9vu8ako	323	12	unable	unable	JJ
cord-007444-c9vu8ako	323	13	to	to	TO
cord-007444-c9vu8ako	323	14	demonstrate	demonstrate	VB
cord-007444-c9vu8ako	323	15	any	any	DT
cord-007444-c9vu8ako	323	16	statistically	statistically	RB
cord-007444-c9vu8ako	323	17	significant	significant	JJ
cord-007444-c9vu8ako	323	18	benefit	benefit	NN
cord-007444-c9vu8ako	323	19	of	of	IN
cord-007444-c9vu8ako	323	20	nasal	nasal	NN
cord-007444-c9vu8ako	323	21	NPPV	NPPV	NNP
cord-007444-c9vu8ako	323	22	over	over	IN
cord-007444-c9vu8ako	323	23	conventional	conventional	JJ
cord-007444-c9vu8ako	323	24	treatment	treatment	NN
cord-007444-c9vu8ako	323	25	in	in	IN
cord-007444-c9vu8ako	323	26	terms	term	NNS
cord-007444-c9vu8ako	323	27	of	of	IN
cord-007444-c9vu8ako	323	28	duration	duration	NN
cord-007444-c9vu8ako	323	29	of	of	IN
cord-007444-c9vu8ako	323	30	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	323	31	,	,	,
cord-007444-c9vu8ako	323	32	dyspnea	dyspnea	NN
cord-007444-c9vu8ako	323	33	scores	score	NNS
cord-007444-c9vu8ako	323	34	,	,	,
cord-007444-c9vu8ako	323	35	arterial	arterial	JJ
cord-007444-c9vu8ako	323	36	blood	blood	NN
cord-007444-c9vu8ako	323	37	gas	gas	NN
cord-007444-c9vu8ako	323	38	measurements	measurement	NNS
cord-007444-c9vu8ako	323	39	,	,	,
cord-007444-c9vu8ako	323	40	or	or	CC
cord-007444-c9vu8ako	323	41	maximal	maximal	JJ
cord-007444-c9vu8ako	323	42	inspiratory	inspiratory	JJ
cord-007444-c9vu8ako	323	43	pressures	pressure	NNS
cord-007444-c9vu8ako	323	44	.	.	.
cord-007444-c9vu8ako	324	1	Patients	patient	NNS
cord-007444-c9vu8ako	324	2	in	in	IN
cord-007444-c9vu8ako	324	3	this	this	DT
cord-007444-c9vu8ako	324	4	trial	trial	NN
cord-007444-c9vu8ako	324	5	,	,	,
cord-007444-c9vu8ako	324	6	however	however	RB
cord-007444-c9vu8ako	324	7	,	,	,
cord-007444-c9vu8ako	324	8	were	be	VBD
cord-007444-c9vu8ako	324	9	clearly	clearly	RB
cord-007444-c9vu8ako	324	10	not	not	RB
cord-007444-c9vu8ako	324	11	as	as	RB
cord-007444-c9vu8ako	324	12	ill	ill	JJ
cord-007444-c9vu8ako	324	13	as	as	IN
cord-007444-c9vu8ako	324	14	those	those	DT
cord-007444-c9vu8ako	324	15	in	in	IN
cord-007444-c9vu8ako	324	16	other	other	JJ
cord-007444-c9vu8ako	324	17	studies	study	NNS
cord-007444-c9vu8ako	324	18	.	.	.
cord-007444-c9vu8ako	325	1	Indeed	indeed	RB
cord-007444-c9vu8ako	325	2	,	,	,
cord-007444-c9vu8ako	325	3	no	no	DT
cord-007444-c9vu8ako	325	4	patient	patient	NN
cord-007444-c9vu8ako	325	5	in	in	IN
cord-007444-c9vu8ako	325	6	either	either	DT
cord-007444-c9vu8ako	325	7	group	group	NN
cord-007444-c9vu8ako	325	8	required	require	VBD
cord-007444-c9vu8ako	325	9	intubation	intubation	NN
cord-007444-c9vu8ako	325	10	.	.	.
cord-007444-c9vu8ako	326	1	Randomized	randomized	JJ
cord-007444-c9vu8ako	326	2	,	,	,
cord-007444-c9vu8ako	326	3	controlled	control	VBN
cord-007444-c9vu8ako	326	4	trials	trial	NNS
cord-007444-c9vu8ako	326	5	of	of	IN
cord-007444-c9vu8ako	326	6	NPPV	NPPV	NNP
cord-007444-c9vu8ako	326	7	for	for	IN
cord-007444-c9vu8ako	326	8	the	the	DT
cord-007444-c9vu8ako	326	9	treatment	treatment	NN
cord-007444-c9vu8ako	326	10	of	of	IN
cord-007444-c9vu8ako	326	11	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	326	12	with	with	IN
cord-007444-c9vu8ako	326	13	hypercarbic	hypercarbic	JJ
cord-007444-c9vu8ako	326	14	respiratory	respiratory	JJ
cord-007444-c9vu8ako	326	15	failure	failure	NN
cord-007444-c9vu8ako	326	16	recently	recently	RB
cord-007444-c9vu8ako	326	17	were	be	VBD
cord-007444-c9vu8ako	326	18	reviewed	review	VBN
cord-007444-c9vu8ako	327	1	systematially.^^	systematially.^^	NNP
cord-007444-c9vu8ako	327	2	The	the	DT
cord-007444-c9vu8ako	327	3	pooled	pool	VBN
cord-007444-c9vu8ako	327	4	odds	odd	NNS
cord-007444-c9vu8ako	327	5	ratio	ratio	NN
cord-007444-c9vu8ako	327	6	for	for	IN
cord-007444-c9vu8ako	327	7	intubation	intubation	NN
cord-007444-c9vu8ako	327	8	following	follow	VBG
cord-007444-c9vu8ako	327	9	NPPV	NPPV	NNP
cord-007444-c9vu8ako	327	10	is	be	VBZ
cord-007444-c9vu8ako	327	11	0.12	0.12	CD
cord-007444-c9vu8ako	327	12	(	(	-LRB-
cord-007444-c9vu8ako	327	13	95	95	CD
cord-007444-c9vu8ako	327	14	%	%	NN
cord-007444-c9vu8ako	327	15	CI	ci	NN
cord-007444-c9vu8ako	327	16	,	,	,
cord-007444-c9vu8ako	327	17	0.05	0.05	CD
cord-007444-c9vu8ako	327	18	-	-	SYM
cord-007444-c9vu8ako	327	19	0.29	0.29	CD
cord-007444-c9vu8ako	327	20	)	)	-RRB-
cord-007444-c9vu8ako	327	21	.	.	.
cord-007444-c9vu8ako	328	1	More	more	RBR
cord-007444-c9vu8ako	328	2	importantly	importantly	RB
cord-007444-c9vu8ako	328	3	,	,	,
cord-007444-c9vu8ako	328	4	however	however	RB
cord-007444-c9vu8ako	328	5	,	,	,
cord-007444-c9vu8ako	328	6	the	the	DT
cord-007444-c9vu8ako	328	7	trials	trial	NNS
cord-007444-c9vu8ako	328	8	that	that	WDT
cord-007444-c9vu8ako	328	9	included	include	VBD
cord-007444-c9vu8ako	328	10	mortality	mortality	NN
cord-007444-c9vu8ako	328	11	as	as	IN
cord-007444-c9vu8ako	328	12	an	an	DT
cord-007444-c9vu8ako	328	13	outcome	outcome	NN
cord-007444-c9vu8ako	328	14	collectively	collectively	RB
cord-007444-c9vu8ako	328	15	demonstrate	demonstrate	VBP
cord-007444-c9vu8ako	328	16	a	a	DT
cord-007444-c9vu8ako	328	17	strong	strong	JJ
cord-007444-c9vu8ako	328	18	survival	survival	NN
cord-007444-c9vu8ako	328	19	benefit	benefit	NN
cord-007444-c9vu8ako	328	20	for	for	IN
cord-007444-c9vu8ako	329	1	NPPV.2	NPPV.2	NNP
cord-007444-c9vu8ako	329	2	*	*	NFP
cord-007444-c9vu8ako	329	3	18	18	CD
cord-007444-c9vu8ako	329	4	,	,	,
cord-007444-c9vu8ako	329	5	21	21	CD
cord-007444-c9vu8ako	329	6	The	the	DT
cord-007444-c9vu8ako	329	7	pooled	pool	VBN
cord-007444-c9vu8ako	329	8	odds	odd	NNS
cord-007444-c9vu8ako	329	9	ratio	ratio	NN
cord-007444-c9vu8ako	329	10	for	for	IN
cord-007444-c9vu8ako	329	11	death	death	NN
cord-007444-c9vu8ako	329	12	is	be	VBZ
cord-007444-c9vu8ako	329	13	0.22	0.22	CD
cord-007444-c9vu8ako	330	1	(	(	-LRB-
cord-007444-c9vu8ako	330	2	95	95	CD
cord-007444-c9vu8ako	330	3	%	%	NN
cord-007444-c9vu8ako	330	4	CI	ci	NN
cord-007444-c9vu8ako	330	5	,	,	,
cord-007444-c9vu8ako	330	6	0.09	0.09	CD
cord-007444-c9vu8ako	330	7	-	-	SYM
cord-007444-c9vu8ako	330	8	0.54	0.54	CD
cord-007444-c9vu8ako	330	9	)	)	-RRB-
cord-007444-c9vu8ako	330	10	.	.	.
cord-007444-c9vu8ako	331	1	Therefore	therefore	RB
cord-007444-c9vu8ako	331	2	,	,	,
cord-007444-c9vu8ako	331	3	at	at	RB
cord-007444-c9vu8ako	331	4	worst	bad	JJS
cord-007444-c9vu8ako	331	5	,	,	,
cord-007444-c9vu8ako	331	6	NPPV	NPPV	NNP
cord-007444-c9vu8ako	331	7	increases	increase	VBZ
cord-007444-c9vu8ako	331	8	the	the	DT
cord-007444-c9vu8ako	331	9	patient	patient	NN
cord-007444-c9vu8ako	331	10	's	's	POS
cord-007444-c9vu8ako	331	11	chance	chance	NN
cord-007444-c9vu8ako	331	12	of	of	IN
cord-007444-c9vu8ako	331	13	surviving	survive	VBG
cord-007444-c9vu8ako	331	14	by	by	IN
cord-007444-c9vu8ako	331	15	nearly	nearly	RB
cord-007444-c9vu8ako	331	16	50	50	CD
cord-007444-c9vu8ako	331	17	%	%	NN
cord-007444-c9vu8ako	331	18	;	;	:
cord-007444-c9vu8ako	331	19	at	at	IN
cord-007444-c9vu8ako	331	20	best	good	JJS
cord-007444-c9vu8ako	331	21	,	,	,
cord-007444-c9vu8ako	331	22	the	the	DT
cord-007444-c9vu8ako	331	23	chance	chance	NN
cord-007444-c9vu8ako	331	24	of	of	IN
cord-007444-c9vu8ako	331	25	survival	survival	NN
cord-007444-c9vu8ako	331	26	is	be	VBZ
cord-007444-c9vu8ako	331	27	90	90	CD
cord-007444-c9vu8ako	331	28	%	%	NN
cord-007444-c9vu8ako	331	29	better	well	JJR
cord-007444-c9vu8ako	331	30	than	than	IN
cord-007444-c9vu8ako	331	31	that	that	DT
cord-007444-c9vu8ako	331	32	of	of	IN
cord-007444-c9vu8ako	331	33	a	a	DT
cord-007444-c9vu8ako	331	34	similar	similar	JJ
cord-007444-c9vu8ako	331	35	patient	patient	NN
cord-007444-c9vu8ako	331	36	not	not	RB
cord-007444-c9vu8ako	331	37	receiving	receive	VBG
cord-007444-c9vu8ako	331	38	NPPV	NPPV	NNP
cord-007444-c9vu8ako	331	39	.	.	.
cord-007444-c9vu8ako	332	1	Improvements	improvement	NNS
cord-007444-c9vu8ako	332	2	in	in	IN
cord-007444-c9vu8ako	332	3	pH	pH	NNP
cord-007444-c9vu8ako	333	1	and	and	CC
cord-007444-c9vu8ako	333	2	PacoZ	PacoZ	NNP
cord-007444-c9vu8ako	333	3	within	within	IN
cord-007444-c9vu8ako	333	4	1	1	CD
cord-007444-c9vu8ako	333	5	hour	hour	NN
cord-007444-c9vu8ako	333	6	of	of	IN
cord-007444-c9vu8ako	333	7	initiating	initiate	VBG
cord-007444-c9vu8ako	333	8	NPPV	NPPV	NNP
cord-007444-c9vu8ako	333	9	and	and	CC
cord-007444-c9vu8ako	333	10	good	good	JJ
cord-007444-c9vu8ako	333	11	level	level	NN
cord-007444-c9vu8ako	333	12	of	of	IN
cord-007444-c9vu8ako	333	13	consciousness	consciousness	NN
cord-007444-c9vu8ako	333	14	at	at	IN
cord-007444-c9vu8ako	333	15	the	the	DT
cord-007444-c9vu8ako	333	16	beginning	beginning	NN
cord-007444-c9vu8ako	333	17	of	of	IN
cord-007444-c9vu8ako	333	18	NPPV	NPPV	NNP
cord-007444-c9vu8ako	333	19	are	be	VBP
cord-007444-c9vu8ako	333	20	associated	associate	VBN
cord-007444-c9vu8ako	333	21	with	with	IN
cord-007444-c9vu8ako	333	22	successful	successful	JJ
cord-007444-c9vu8ako	333	23	responses	response	NNS
cord-007444-c9vu8ako	333	24	to	to	IN
cord-007444-c9vu8ako	333	25	NPPV	NPPV	NNP
cord-007444-c9vu8ako	333	26	in	in	IN
cord-007444-c9vu8ako	333	27	patients	patient	NNS
cord-007444-c9vu8ako	333	28	with	with	IN
cord-007444-c9vu8ako	333	29	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	333	30	and	and	CC
cord-007444-c9vu8ako	333	31	respiratory	respiratory	JJ
cord-007444-c9vu8ako	333	32	acido	acido	NNP
cord-007444-c9vu8ako	334	1	~is.~	~is.~	NNP
cord-007444-c9vu8ako	334	2	Malnutrition	malnutrition	NN
cord-007444-c9vu8ako	334	3	is	be	VBZ
cord-007444-c9vu8ako	334	4	common	common	JJ
cord-007444-c9vu8ako	334	5	among	among	IN
cord-007444-c9vu8ako	334	6	patients	patient	NNS
cord-007444-c9vu8ako	334	7	with	with	IN
cord-007444-c9vu8ako	334	8	COPD	COPD	NNP
cord-007444-c9vu8ako	334	9	and	and	CC
cord-007444-c9vu8ako	334	10	increases	increase	VBZ
cord-007444-c9vu8ako	334	11	the	the	DT
cord-007444-c9vu8ako	334	12	morbidity	morbidity	NN
cord-007444-c9vu8ako	334	13	and	and	CC
cord-007444-c9vu8ako	334	14	mortality	mortality	NN
cord-007444-c9vu8ako	334	15	associated	associate	VBN
cord-007444-c9vu8ako	334	16	with	with	IN
cord-007444-c9vu8ako	334	17	the	the	DT
cord-007444-c9vu8ako	334	18	disease	disease	NN
cord-007444-c9vu8ako	334	19	.	.	.
cord-007444-c9vu8ako	335	1	The	the	DT
cord-007444-c9vu8ako	335	2	Veterans	Veterans	NNPS
cord-007444-c9vu8ako	335	3	Administration	Administration	NNP
cord-007444-c9vu8ako	335	4	Cooperative	Cooperative	NNP
cord-007444-c9vu8ako	335	5	Study	Study	NNP
cord-007444-c9vu8ako	335	6	of	of	IN
cord-007444-c9vu8ako	335	7	Pulmonary	Pulmonary	NNP
cord-007444-c9vu8ako	335	8	Function98	Function98	NNP
cord-007444-c9vu8ako	335	9	showed	show	VBD
cord-007444-c9vu8ako	335	10	that	that	IN
cord-007444-c9vu8ako	335	11	patients	patient	NNS
cord-007444-c9vu8ako	335	12	with	with	IN
cord-007444-c9vu8ako	335	13	FEVl	FEVl	NNS
cord-007444-c9vu8ako	335	14	less	less	JJR
cord-007444-c9vu8ako	335	15	than	than	IN
cord-007444-c9vu8ako	335	16	or	or	CC
cord-007444-c9vu8ako	335	17	equal	equal	JJ
cord-007444-c9vu8ako	335	18	to	to	IN
cord-007444-c9vu8ako	335	19	0.5	0.5	CD
cord-007444-c9vu8ako	335	20	L	l	NN
cord-007444-c9vu8ako	335	21	weighed	weigh	VBD
cord-007444-c9vu8ako	335	22	less	less	JJR
cord-007444-c9vu8ako	335	23	than	than	IN
cord-007444-c9vu8ako	335	24	82	82	CD
cord-007444-c9vu8ako	335	25	%	%	NN
cord-007444-c9vu8ako	335	26	of	of	IN
cord-007444-c9vu8ako	335	27	their	-PRON-	PRP$
cord-007444-c9vu8ako	335	28	ideal	ideal	JJ
cord-007444-c9vu8ako	335	29	body	body	NN
cord-007444-c9vu8ako	335	30	weight	weight	NN
cord-007444-c9vu8ako	335	31	(	(	-LRB-
cord-007444-c9vu8ako	335	32	IBW	IBW	NNP
cord-007444-c9vu8ako	335	33	)	)	-RRB-
cord-007444-c9vu8ako	335	34	,	,	,
cord-007444-c9vu8ako	335	35	compared	compare	VBN
cord-007444-c9vu8ako	335	36	with	with	IN
cord-007444-c9vu8ako	335	37	near	near	IN
cord-007444-c9vu8ako	335	38	normal	normal	JJ
cord-007444-c9vu8ako	335	39	body	body	NN
cord-007444-c9vu8ako	335	40	weight	weight	NN
cord-007444-c9vu8ako	335	41	in	in	IN
cord-007444-c9vu8ako	335	42	less	less	RBR
cord-007444-c9vu8ako	335	43	severely	severely	RB
cord-007444-c9vu8ako	335	44	impaired	impair	VBN
cord-007444-c9vu8ako	335	45	patients	patient	NNS
cord-007444-c9vu8ako	335	46	.	.	.
cord-007444-c9vu8ako	336	1	In	in	IN
cord-007444-c9vu8ako	336	2	another	another	DT
cord-007444-c9vu8ako	336	3	study,133	study,133	NN
cord-007444-c9vu8ako	336	4	43	43	CD
cord-007444-c9vu8ako	336	5	%	%	NN
cord-007444-c9vu8ako	336	6	of	of	IN
cord-007444-c9vu8ako	336	7	patients	patient	NNS
cord-007444-c9vu8ako	336	8	with	with	IN
cord-007444-c9vu8ako	336	9	emphysema	emphysema	NN
cord-007444-c9vu8ako	336	10	were	be	VBD
cord-007444-c9vu8ako	336	11	found	find	VBN
cord-007444-c9vu8ako	336	12	to	to	TO
cord-007444-c9vu8ako	336	13	weigh	weigh	VB
cord-007444-c9vu8ako	336	14	less	less	JJR
cord-007444-c9vu8ako	336	15	than	than	IN
cord-007444-c9vu8ako	336	16	90	90	CD
cord-007444-c9vu8ako	336	17	%	%	NN
cord-007444-c9vu8ako	336	18	of	of	IN
cord-007444-c9vu8ako	336	19	their	-PRON-	PRP$
cord-007444-c9vu8ako	336	20	IBW	IBW	NNP
cord-007444-c9vu8ako	336	21	.	.	.
cord-007444-c9vu8ako	337	1	Furthermore	furthermore	RB
cord-007444-c9vu8ako	337	2	,	,	,
cord-007444-c9vu8ako	337	3	reported	report	VBD
cord-007444-c9vu8ako	337	4	that	that	IN
cord-007444-c9vu8ako	337	5	more	more	JJR
cord-007444-c9vu8ako	337	6	than	than	IN
cord-007444-c9vu8ako	337	7	70	70	CD
cord-007444-c9vu8ako	337	8	%	%	NN
cord-007444-c9vu8ako	337	9	of	of	IN
cord-007444-c9vu8ako	337	10	hospitalized	hospitalize	VBN
cord-007444-c9vu8ako	337	11	patients	patient	NNS
cord-007444-c9vu8ako	337	12	with	with	IN
cord-007444-c9vu8ako	337	13	COPD	COPD	NNP
cord-007444-c9vu8ako	337	14	had	have	VBD
cord-007444-c9vu8ako	337	15	evidence	evidence	NN
cord-007444-c9vu8ako	337	16	of	of	IN
cord-007444-c9vu8ako	337	17	weight	weight	NN
cord-007444-c9vu8ako	337	18	loss	loss	NN
cord-007444-c9vu8ako	337	19	.	.	.
cord-007444-c9vu8ako	338	1	Pingletongl	Pingletongl	NNP
cord-007444-c9vu8ako	338	2	found	find	VBD
cord-007444-c9vu8ako	338	3	that	that	IN
cord-007444-c9vu8ako	338	4	,	,	,
cord-007444-c9vu8ako	338	5	among	among	IN
cord-007444-c9vu8ako	338	6	ventilated	ventilate	VBN
cord-007444-c9vu8ako	338	7	patients	patient	NNS
cord-007444-c9vu8ako	338	8	,	,	,
cord-007444-c9vu8ako	338	9	mortality	mortality	NN
cord-007444-c9vu8ako	338	10	was	be	VBD
cord-007444-c9vu8ako	338	11	significantly	significantly	RB
cord-007444-c9vu8ako	338	12	higher	high	JJR
cord-007444-c9vu8ako	338	13	in	in	IN
cord-007444-c9vu8ako	338	14	those	those	DT
cord-007444-c9vu8ako	338	15	who	who	WP
cord-007444-c9vu8ako	338	16	were	be	VBD
cord-007444-c9vu8ako	338	17	poorly	poorly	RB
cord-007444-c9vu8ako	338	18	nourished	nourish	VBN
cord-007444-c9vu8ako	338	19	than	than	IN
cord-007444-c9vu8ako	338	20	in	in	IN
cord-007444-c9vu8ako	338	21	those	those	DT
cord-007444-c9vu8ako	338	22	with	with	IN
cord-007444-c9vu8ako	338	23	better	well	JJR
cord-007444-c9vu8ako	338	24	nutritional	nutritional	JJ
cord-007444-c9vu8ako	338	25	status	status	NN
cord-007444-c9vu8ako	338	26	.	.	.
cord-007444-c9vu8ako	339	1	Poorly	poorly	RB
cord-007444-c9vu8ako	339	2	nourished	nourish	VBN
cord-007444-c9vu8ako	339	3	patients	patient	NNS
cord-007444-c9vu8ako	339	4	also	also	RB
cord-007444-c9vu8ako	339	5	had	have	VBD
cord-007444-c9vu8ako	339	6	a	a	DT
cord-007444-c9vu8ako	339	7	significantly	significantly	RB
cord-007444-c9vu8ako	339	8	higher	high	JJR
cord-007444-c9vu8ako	339	9	frequency	frequency	NN
cord-007444-c9vu8ako	339	10	of	of	IN
cord-007444-c9vu8ako	339	11	hypercapnia	hypercapnia	NN
cord-007444-c9vu8ako	339	12	.	.	.
cord-007444-c9vu8ako	340	1	The	the	DT
cord-007444-c9vu8ako	340	2	principal	principal	JJ
cord-007444-c9vu8ako	340	3	effects	effect	NNS
cord-007444-c9vu8ako	340	4	of	of	IN
cord-007444-c9vu8ako	340	5	malnutrition	malnutrition	NN
cord-007444-c9vu8ako	340	6	upon	upon	IN
cord-007444-c9vu8ako	340	7	the	the	DT
cord-007444-c9vu8ako	340	8	respiratory	respiratory	JJ
cord-007444-c9vu8ako	340	9	system	system	NN
cord-007444-c9vu8ako	340	10	are	be	VBP
cord-007444-c9vu8ako	340	11	thought	think	VBN
cord-007444-c9vu8ako	340	12	to	to	TO
cord-007444-c9vu8ako	340	13	be	be	VB
cord-007444-c9vu8ako	340	14	worsened	worsen	VBN
cord-007444-c9vu8ako	340	15	respiratory	respiratory	JJ
cord-007444-c9vu8ako	340	16	muscle	muscle	NN
cord-007444-c9vu8ako	340	17	function	function	NN
cord-007444-c9vu8ako	340	18	,	,	,
cord-007444-c9vu8ako	340	19	impairment	impairment	NN
cord-007444-c9vu8ako	340	20	of	of	IN
cord-007444-c9vu8ako	340	21	ventilatory	ventilatory	JJ
cord-007444-c9vu8ako	340	22	drive	drive	NN
cord-007444-c9vu8ako	340	23	,	,	,
cord-007444-c9vu8ako	340	24	and	and	CC
cord-007444-c9vu8ako	340	25	immune	immune	JJ
cord-007444-c9vu8ako	340	26	dysfunction	dysfunction	NN
cord-007444-c9vu8ako	340	27	.	.	.
cord-007444-c9vu8ako	341	1	Malnutrition	malnutrition	NN
cord-007444-c9vu8ako	341	2	impairs	impair	VBZ
cord-007444-c9vu8ako	341	3	muscle	muscle	NN
cord-007444-c9vu8ako	341	4	function	function	NN
cord-007444-c9vu8ako	341	5	by	by	IN
cord-007444-c9vu8ako	341	6	reducing	reduce	VBG
cord-007444-c9vu8ako	341	7	the	the	DT
cord-007444-c9vu8ako	341	8	availability	availability	NN
cord-007444-c9vu8ako	341	9	of	of	IN
cord-007444-c9vu8ako	341	10	energy	energy	NN
cord-007444-c9vu8ako	341	11	substrates	substrate	NNS
cord-007444-c9vu8ako	341	12	such	such	JJ
cord-007444-c9vu8ako	341	13	as	as	IN
cord-007444-c9vu8ako	341	14	glycogen	glycogen	NN
cord-007444-c9vu8ako	341	15	and	and	CC
cord-007444-c9vu8ako	341	16	phosphate	phosphate	NN
cord-007444-c9vu8ako	341	17	and	and	CC
cord-007444-c9vu8ako	341	18	by	by	IN
cord-007444-c9vu8ako	341	19	altering	alter	VBG
cord-007444-c9vu8ako	341	20	the	the	DT
cord-007444-c9vu8ako	341	21	structure	structure	NN
cord-007444-c9vu8ako	341	22	of	of	IN
cord-007444-c9vu8ako	341	23	muscle	muscle	NN
cord-007444-c9vu8ako	341	24	fibers	fiber	NNS
cord-007444-c9vu8ako	341	25	.	.	.
cord-007444-c9vu8ako	342	1	When	when	WRB
cord-007444-c9vu8ako	342	2	combined	combine	VBN
cord-007444-c9vu8ako	342	3	with	with	IN
cord-007444-c9vu8ako	342	4	intercurrent	intercurrent	NN
cord-007444-c9vu8ako	342	5	airway	airway	NN
cord-007444-c9vu8ako	342	6	infection	infection	NN
cord-007444-c9vu8ako	342	7	and	and	CC
cord-007444-c9vu8ako	342	8	the	the	DT
cord-007444-c9vu8ako	342	9	mechanical	mechanical	JJ
cord-007444-c9vu8ako	342	10	disadvantage	disadvantage	NN
cord-007444-c9vu8ako	342	11	of	of	IN
cord-007444-c9vu8ako	342	12	the	the	DT
cord-007444-c9vu8ako	342	13	diaphragm	diaphragm	NN
cord-007444-c9vu8ako	342	14	in	in	IN
cord-007444-c9vu8ako	342	15	COPD	COPD	NNP
cord-007444-c9vu8ako	342	16	,	,	,
cord-007444-c9vu8ako	342	17	malnutrition	malnutrition	NN
cord-007444-c9vu8ako	342	18	may	may	MD
cord-007444-c9vu8ako	342	19	have	have	VB
cord-007444-c9vu8ako	342	20	a	a	DT
cord-007444-c9vu8ako	342	21	profound	profound	JJ
cord-007444-c9vu8ako	342	22	effect	effect	NN
cord-007444-c9vu8ako	342	23	on	on	IN
cord-007444-c9vu8ako	342	24	respiratory	respiratory	JJ
cord-007444-c9vu8ako	342	25	muscle	muscle	NN
cord-007444-c9vu8ako	342	26	mechanics	mechanic	NNS
cord-007444-c9vu8ako	342	27	.	.	.
cord-007444-c9vu8ako	343	1	Experimental	experimental	JJ
cord-007444-c9vu8ako	343	2	evidence	evidence	NN
cord-007444-c9vu8ako	343	3	for	for	IN
cord-007444-c9vu8ako	343	4	blunted	blunted	JJ
cord-007444-c9vu8ako	343	5	hypoxic	hypoxic	JJ
cord-007444-c9vu8ako	343	6	drive	drive	NN
cord-007444-c9vu8ako	343	7	in	in	IN
cord-007444-c9vu8ako	343	8	response	response	NN
cord-007444-c9vu8ako	343	9	to	to	IN
cord-007444-c9vu8ako	343	10	semistarvation	semistarvation	NN
cord-007444-c9vu8ako	343	11	suggests	suggest	VBZ
cord-007444-c9vu8ako	343	12	another	another	DT
cord-007444-c9vu8ako	343	13	mechanism	mechanism	NN
cord-007444-c9vu8ako	343	14	by	by	IN
cord-007444-c9vu8ako	343	15	which	which	WDT
cord-007444-c9vu8ako	343	16	patients	patient	NNS
cord-007444-c9vu8ako	343	17	with	with	IN
cord-007444-c9vu8ako	343	18	COPD	COPD	NNP
cord-007444-c9vu8ako	343	19	may	may	MD
cord-007444-c9vu8ako	343	20	be	be	VB
cord-007444-c9vu8ako	343	21	predisposed	predisposed	JJ
cord-007444-c9vu8ako	343	22	to	to	IN
cord-007444-c9vu8ako	343	23	respiratory	respiratory	JJ
cord-007444-c9vu8ako	343	24	failure.91	failure.91	NNS
cord-007444-c9vu8ako	343	25	,	,	,
cord-007444-c9vu8ako	343	26	133	133	CD
cord-007444-c9vu8ako	343	27	No	no	DT
cord-007444-c9vu8ako	343	28	randomized	randomized	JJ
cord-007444-c9vu8ako	343	29	,	,	,
cord-007444-c9vu8ako	343	30	controlled	control	VBN
cord-007444-c9vu8ako	343	31	trial	trial	NN
cord-007444-c9vu8ako	343	32	has	have	VBZ
cord-007444-c9vu8ako	343	33	demonstrated	demonstrate	VBN
cord-007444-c9vu8ako	343	34	reduced	reduced	JJ
cord-007444-c9vu8ako	343	35	morbidity	morbidity	NN
cord-007444-c9vu8ako	343	36	and	and	CC
cord-007444-c9vu8ako	343	37	mortality	mortality	NN
cord-007444-c9vu8ako	343	38	as	as	IN
cord-007444-c9vu8ako	343	39	a	a	DT
cord-007444-c9vu8ako	343	40	result	result	NN
cord-007444-c9vu8ako	343	41	of	of	IN
cord-007444-c9vu8ako	343	42	nutritional	nutritional	JJ
cord-007444-c9vu8ako	343	43	support	support	NN
cord-007444-c9vu8ako	343	44	during	during	IN
cord-007444-c9vu8ako	343	45	acute	acute	JJ
cord-007444-c9vu8ako	343	46	respiratory	respiratory	JJ
cord-007444-c9vu8ako	343	47	failure	failure	NN
cord-007444-c9vu8ako	343	48	.	.	.
cord-007444-c9vu8ako	344	1	Nevertheless	nevertheless	RB
cord-007444-c9vu8ako	344	2	,	,	,
cord-007444-c9vu8ako	344	3	clinicians	clinician	NNS
cord-007444-c9vu8ako	344	4	should	should	MD
cord-007444-c9vu8ako	344	5	be	be	VB
cord-007444-c9vu8ako	344	6	able	able	JJ
cord-007444-c9vu8ako	344	7	to	to	TO
cord-007444-c9vu8ako	344	8	identify	identify	VB
cord-007444-c9vu8ako	344	9	malnourished	malnourished	JJ
cord-007444-c9vu8ako	344	10	patients	patient	NNS
cord-007444-c9vu8ako	344	11	and	and	CC
cord-007444-c9vu8ako	344	12	understand	understand	VB
cord-007444-c9vu8ako	344	13	the	the	DT
cord-007444-c9vu8ako	344	14	goals	goal	NNS
cord-007444-c9vu8ako	344	15	of	of	IN
cord-007444-c9vu8ako	344	16	nutritional	nutritional	JJ
cord-007444-c9vu8ako	344	17	therapy	therapy	NN
cord-007444-c9vu8ako	344	18	.	.	.
cord-007444-c9vu8ako	345	1	Particular	particular	JJ
cord-007444-c9vu8ako	345	2	attention	attention	NN
cord-007444-c9vu8ako	345	3	should	should	MD
cord-007444-c9vu8ako	345	4	be	be	VB
cord-007444-c9vu8ako	345	5	paid	pay	VBN
cord-007444-c9vu8ako	345	6	to	to	IN
cord-007444-c9vu8ako	345	7	patients	patient	NNS
cord-007444-c9vu8ako	345	8	with	with	IN
cord-007444-c9vu8ako	345	9	hypercatabolic	hypercatabolic	JJ
cord-007444-c9vu8ako	345	10	states	state	NNS
cord-007444-c9vu8ako	345	11	that	that	WDT
cord-007444-c9vu8ako	345	12	increase	increase	VBP
cord-007444-c9vu8ako	345	13	the	the	DT
cord-007444-c9vu8ako	345	14	risk	risk	NN
cord-007444-c9vu8ako	345	15	for	for	IN
cord-007444-c9vu8ako	345	16	protein	protein	NN
cord-007444-c9vu8ako	345	17	-	-	HYPH
cord-007444-c9vu8ako	345	18	calorie	calorie	NN
cord-007444-c9vu8ako	345	19	malnutrition	malnutrition	NN
cord-007444-c9vu8ako	345	20	.	.	.
cord-007444-c9vu8ako	346	1	The	the	DT
cord-007444-c9vu8ako	346	2	Subjective	Subjective	NNP
cord-007444-c9vu8ako	346	3	Global	Global	NNP
cord-007444-c9vu8ako	346	4	Assessment	Assessment	NNP
cord-007444-c9vu8ako	346	5	and	and	CC
cord-007444-c9vu8ako	346	6	the	the	DT
cord-007444-c9vu8ako	346	7	Harris	Harris	NNP
cord-007444-c9vu8ako	346	8	-	-	HYPH
cord-007444-c9vu8ako	346	9	Benedict	Benedict	NNP
cord-007444-c9vu8ako	346	10	equation	equation	NN
cord-007444-c9vu8ako	346	11	are	be	VBP
cord-007444-c9vu8ako	346	12	two	two	CD
cord-007444-c9vu8ako	346	13	valid	valid	JJ
cord-007444-c9vu8ako	346	14	clinical	clinical	JJ
cord-007444-c9vu8ako	346	15	instruments	instrument	NNS
cord-007444-c9vu8ako	346	16	for	for	IN
cord-007444-c9vu8ako	346	17	assessing	assess	VBG
cord-007444-c9vu8ako	346	18	malnutrition	malnutrition	NN
cord-007444-c9vu8ako	346	19	and	and	CC
cord-007444-c9vu8ako	346	20	planning	plan	VBG
cord-007444-c9vu8ako	346	21	nutritional	nutritional	JJ
cord-007444-c9vu8ako	346	22	therapy	therapy	NN
cord-007444-c9vu8ako	346	23	.	.	.
cord-007444-c9vu8ako	347	1	They	-PRON-	PRP
cord-007444-c9vu8ako	347	2	are	be	VBP
cord-007444-c9vu8ako	347	3	reviewed	review	VBN
cord-007444-c9vu8ako	347	4	elsewhere	elsewhere	RB
cord-007444-c9vu8ako	347	5	?	?	.
cord-007444-c9vu8ako	348	1	"	"	''
cord-007444-c9vu8ako	349	1	91	91	CD
cord-007444-c9vu8ako	350	1	In	in	IN
cord-007444-c9vu8ako	350	2	general	general	JJ
cord-007444-c9vu8ako	350	3	,	,	,
cord-007444-c9vu8ako	350	4	the	the	DT
cord-007444-c9vu8ako	350	5	goals	goal	NNS
cord-007444-c9vu8ako	350	6	of	of	IN
cord-007444-c9vu8ako	350	7	nutritional	nutritional	JJ
cord-007444-c9vu8ako	350	8	supplementation	supplementation	NN
cord-007444-c9vu8ako	350	9	among	among	IN
cord-007444-c9vu8ako	350	10	patients	patient	NNS
cord-007444-c9vu8ako	350	11	with	with	IN
cord-007444-c9vu8ako	350	12	acute	acute	JJ
cord-007444-c9vu8ako	350	13	respiratory	respiratory	JJ
cord-007444-c9vu8ako	350	14	failure	failure	NN
cord-007444-c9vu8ako	350	15	consist	consist	VBP
cord-007444-c9vu8ako	350	16	of	of	IN
cord-007444-c9vu8ako	350	17	maintaining	maintain	VBG
cord-007444-c9vu8ako	350	18	body	body	NN
cord-007444-c9vu8ako	350	19	weight	weight	NN
cord-007444-c9vu8ako	350	20	and	and	CC
cord-007444-c9vu8ako	350	21	preventing	prevent	VBG
cord-007444-c9vu8ako	350	22	protein	protein	NN
cord-007444-c9vu8ako	350	23	breakdown	breakdown	NN
cord-007444-c9vu8ako	350	24	.	.	.
cord-007444-c9vu8ako	351	1	The	the	DT
cord-007444-c9vu8ako	351	2	effects	effect	NNS
cord-007444-c9vu8ako	351	3	of	of	IN
cord-007444-c9vu8ako	351	4	malnutrition	malnutrition	NN
cord-007444-c9vu8ako	351	5	and	and	CC
cord-007444-c9vu8ako	351	6	nutritional	nutritional	JJ
cord-007444-c9vu8ako	351	7	supplementation	supplementation	NN
cord-007444-c9vu8ako	351	8	in	in	IN
cord-007444-c9vu8ako	351	9	patients	patient	NNS
cord-007444-c9vu8ako	351	10	with	with	IN
cord-007444-c9vu8ako	351	11	COPD	COPD	NNP
cord-007444-c9vu8ako	351	12	are	be	VBP
cord-007444-c9vu8ako	351	13	discussed	discuss	VBN
cord-007444-c9vu8ako	351	14	in	in	IN
cord-007444-c9vu8ako	351	15	more	more	JJR
cord-007444-c9vu8ako	351	16	detail	detail	NN
cord-007444-c9vu8ako	351	17	in	in	IN
cord-007444-c9vu8ako	351	18	the	the	DT
cord-007444-c9vu8ako	351	19	article	article	NN
cord-007444-c9vu8ako	351	20	by	by	IN
cord-007444-c9vu8ako	351	21	Schols	Schols	NNP
cord-007444-c9vu8ako	351	22	and	and	CC
cord-007444-c9vu8ako	351	23	Wouters	Wouters	NNPS
cord-007444-c9vu8ako	351	24	in	in	IN
cord-007444-c9vu8ako	351	25	this	this	DT
cord-007444-c9vu8ako	351	26	issue	issue	NN
cord-007444-c9vu8ako	351	27	.	.	.
cord-007444-c9vu8ako	352	1	The	the	DT
cord-007444-c9vu8ako	352	2	value	value	NN
cord-007444-c9vu8ako	352	3	of	of	IN
cord-007444-c9vu8ako	352	4	chest	chest	NN
cord-007444-c9vu8ako	352	5	physiotherapy	physiotherapy	NN
cord-007444-c9vu8ako	352	6	(	(	-LRB-
cord-007444-c9vu8ako	352	7	postural	postural	JJ
cord-007444-c9vu8ako	352	8	drainage	drainage	NN
cord-007444-c9vu8ako	352	9	with	with	IN
cord-007444-c9vu8ako	352	10	or	or	CC
cord-007444-c9vu8ako	352	11	without	without	IN
cord-007444-c9vu8ako	352	12	chest	chest	NN
cord-007444-c9vu8ako	352	13	percussion	percussion	NN
cord-007444-c9vu8ako	352	14	)	)	-RRB-
cord-007444-c9vu8ako	352	15	in	in	IN
cord-007444-c9vu8ako	352	16	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	352	17	has	have	VBZ
cord-007444-c9vu8ako	352	18	not	not	RB
cord-007444-c9vu8ako	352	19	been	be	VBN
cord-007444-c9vu8ako	352	20	demonstrated	demonstrate	VBN
cord-007444-c9vu8ako	352	21	.	.	.
cord-007444-c9vu8ako	353	1	Studies	study	NNS
cord-007444-c9vu8ako	353	2	of	of	IN
cord-007444-c9vu8ako	353	3	patients	patient	NNS
cord-007444-c9vu8ako	353	4	with	with	IN
cord-007444-c9vu8ako	353	5	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	353	6	have	have	VBP
cord-007444-c9vu8ako	353	7	failed	fail	VBN
cord-007444-c9vu8ako	353	8	to	to	TO
cord-007444-c9vu8ako	353	9	demonstrate	demonstrate	VB
cord-007444-c9vu8ako	353	10	a	a	DT
cord-007444-c9vu8ako	353	11	beneficial	beneficial	JJ
cord-007444-c9vu8ako	353	12	effect	effect	NN
cord-007444-c9vu8ako	353	13	of	of	IN
cord-007444-c9vu8ako	353	14	chest	chest	NN
cord-007444-c9vu8ako	353	15	physiotherapy	physiotherapy	NN
cord-007444-c9vu8ako	353	16	upon	upon	IN
cord-007444-c9vu8ako	353	17	sputum	sputum	NN
cord-007444-c9vu8ako	353	18	volume	volume	NN
cord-007444-c9vu8ako	353	19	,	,	,
cord-007444-c9vu8ako	353	20	gas	gas	NN
cord-007444-c9vu8ako	353	21	exchange	exchange	NN
cord-007444-c9vu8ako	353	22	,	,	,
cord-007444-c9vu8ako	353	23	or	or	CC
cord-007444-c9vu8ako	353	24	spirometry.66	spirometry.66	NNP
cord-007444-c9vu8ako	353	25	One	one	CD
cord-007444-c9vu8ako	353	26	trialz7	trialz7	NN
cord-007444-c9vu8ako	353	27	documented	document	VBD
cord-007444-c9vu8ako	353	28	a	a	DT
cord-007444-c9vu8ako	353	29	transient	transient	JJ
cord-007444-c9vu8ako	353	30	but	but	CC
cord-007444-c9vu8ako	353	31	significant	significant	JJ
cord-007444-c9vu8ako	353	32	decrease	decrease	NN
cord-007444-c9vu8ako	353	33	in	in	IN
cord-007444-c9vu8ako	353	34	FEV	FEV	NNP
cord-007444-c9vu8ako	353	35	,	,	,
cord-007444-c9vu8ako	353	36	as	as	IN
cord-007444-c9vu8ako	353	37	a	a	DT
cord-007444-c9vu8ako	353	38	result	result	NN
cord-007444-c9vu8ako	353	39	of	of	IN
cord-007444-c9vu8ako	353	40	bronchoconstriction	bronchoconstriction	NN
cord-007444-c9vu8ako	353	41	following	follow	VBG
cord-007444-c9vu8ako	353	42	chest	chest	NN
cord-007444-c9vu8ako	353	43	percussion	percussion	NN
cord-007444-c9vu8ako	353	44	and	and	CC
cord-007444-c9vu8ako	353	45	vibration	vibration	NN
cord-007444-c9vu8ako	353	46	.	.	.
cord-007444-c9vu8ako	354	1	Some	some	DT
cord-007444-c9vu8ako	354	2	evidence	evidence	NN
cord-007444-c9vu8ako	354	3	suggests	suggest	VBZ
cord-007444-c9vu8ako	354	4	that	that	IN
cord-007444-c9vu8ako	354	5	patients	patient	NNS
cord-007444-c9vu8ako	354	6	with	with	IN
cord-007444-c9vu8ako	354	7	larger	large	JJR
cord-007444-c9vu8ako	354	8	volumes	volume	NNS
cord-007444-c9vu8ako	354	9	of	of	IN
cord-007444-c9vu8ako	354	10	airway	airway	NN
cord-007444-c9vu8ako	354	11	secretions	secretion	NNS
cord-007444-c9vu8ako	354	12	(	(	-LRB-
cord-007444-c9vu8ako	354	13	>	>	NFP
cord-007444-c9vu8ako	354	14	25	25	CD
cord-007444-c9vu8ako	354	15	mL	ml	NN
cord-007444-c9vu8ako	354	16	/	/	SYM
cord-007444-c9vu8ako	354	17	d	d	NN
cord-007444-c9vu8ako	354	18	)	)	-RRB-
cord-007444-c9vu8ako	354	19	,	,	,
cord-007444-c9vu8ako	354	20	particularly	particularly	RB
cord-007444-c9vu8ako	354	21	those	those	DT
cord-007444-c9vu8ako	354	22	with	with	IN
cord-007444-c9vu8ako	354	23	bronchiectasis	bronchiectasis	NN
cord-007444-c9vu8ako	354	24	,	,	,
cord-007444-c9vu8ako	354	25	may	may	MD
cord-007444-c9vu8ako	354	26	benefit	benefit	VB
cord-007444-c9vu8ako	354	27	.	.	.
cord-007444-c9vu8ako	355	1	In	in	IN
cord-007444-c9vu8ako	355	2	some	some	DT
cord-007444-c9vu8ako	355	3	guidelines	guideline	NNS
cord-007444-c9vu8ako	355	4	,	,	,
cord-007444-c9vu8ako	355	5	therefore	therefore	RB
cord-007444-c9vu8ako	355	6	,	,	,
cord-007444-c9vu8ako	355	7	chest	chest	NN
cord-007444-c9vu8ako	355	8	physiotherapy	physiotherapy	NN
cord-007444-c9vu8ako	355	9	has	have	VBZ
cord-007444-c9vu8ako	355	10	been	be	VBN
cord-007444-c9vu8ako	355	11	advocated	advocate	VBN
cord-007444-c9vu8ako	355	12	in	in	IN
cord-007444-c9vu8ako	355	13	this	this	DT
cord-007444-c9vu8ako	355	14	~ituation.~	~ituation.~	NNP
cord-007444-c9vu8ako	356	1	In	in	IN
cord-007444-c9vu8ako	356	2	general	general	JJ
cord-007444-c9vu8ako	356	3	,	,	,
cord-007444-c9vu8ako	356	4	however	however	RB
cord-007444-c9vu8ako	356	5	,	,	,
cord-007444-c9vu8ako	356	6	it	-PRON-	PRP
cord-007444-c9vu8ako	356	7	is	be	VBZ
cord-007444-c9vu8ako	356	8	not	not	RB
cord-007444-c9vu8ako	356	9	recommended	recommend	VBN
cord-007444-c9vu8ako	356	10	in	in	IN
cord-007444-c9vu8ako	356	11	the	the	DT
cord-007444-c9vu8ako	356	12	routine	routine	JJ
cord-007444-c9vu8ako	356	13	management	management	NN
cord-007444-c9vu8ako	356	14	of	of	IN
cord-007444-c9vu8ako	356	15	AECOPD.2	AECOPD.2	NNP
cord-007444-c9vu8ako	356	16	°	°	NNP
cord-007444-c9vu8ako	357	1	Although	although	IN
cord-007444-c9vu8ako	357	2	outcome	outcome	NN
cord-007444-c9vu8ako	357	3	data	datum	NNS
cord-007444-c9vu8ako	357	4	are	be	VBP
cord-007444-c9vu8ako	357	5	important	important	JJ
cord-007444-c9vu8ako	357	6	,	,	,
cord-007444-c9vu8ako	357	7	caution	caution	NN
cord-007444-c9vu8ako	357	8	is	be	VBZ
cord-007444-c9vu8ako	357	9	required	require	VBN
cord-007444-c9vu8ako	357	10	in	in	IN
cord-007444-c9vu8ako	357	11	their	-PRON-	PRP$
cord-007444-c9vu8ako	357	12	interpretation	interpretation	NN
cord-007444-c9vu8ako	357	13	.	.	.
cord-007444-c9vu8ako	358	1	Because	because	IN
cord-007444-c9vu8ako	358	2	data	datum	NNS
cord-007444-c9vu8ako	358	3	are	be	VBP
cord-007444-c9vu8ako	358	4	generated	generate	VBN
cord-007444-c9vu8ako	358	5	by	by	IN
cord-007444-c9vu8ako	358	6	observing	observe	VBG
cord-007444-c9vu8ako	358	7	large	large	JJ
cord-007444-c9vu8ako	358	8	numbers	number	NNS
cord-007444-c9vu8ako	358	9	of	of	IN
cord-007444-c9vu8ako	358	10	patients	patient	NNS
cord-007444-c9vu8ako	358	11	,	,	,
cord-007444-c9vu8ako	358	12	typically	typically	RB
cord-007444-c9vu8ako	358	13	in	in	IN
cord-007444-c9vu8ako	358	14	tertiary	tertiary	JJ
cord-007444-c9vu8ako	358	15	referral	referral	NN
cord-007444-c9vu8ako	358	16	centers	center	NNS
cord-007444-c9vu8ako	358	17	,	,	,
cord-007444-c9vu8ako	358	18	the	the	DT
cord-007444-c9vu8ako	358	19	pertinence	pertinence	NN
cord-007444-c9vu8ako	358	20	of	of	IN
cord-007444-c9vu8ako	358	21	these	these	DT
cord-007444-c9vu8ako	358	22	data	datum	NNS
cord-007444-c9vu8ako	358	23	to	to	IN
cord-007444-c9vu8ako	358	24	individual	individual	JJ
cord-007444-c9vu8ako	358	25	patients	patient	NNS
cord-007444-c9vu8ako	358	26	may	may	MD
cord-007444-c9vu8ako	358	27	be	be	VB
cord-007444-c9vu8ako	358	28	limited	limit	VBN
cord-007444-c9vu8ako	358	29	,	,	,
cord-007444-c9vu8ako	358	30	especially	especially	RB
cord-007444-c9vu8ako	358	31	outside	outside	RB
cord-007444-c9vu8ako	358	32	of	of	IN
cord-007444-c9vu8ako	358	33	major	major	JJ
cord-007444-c9vu8ako	358	34	centers	center	NNS
cord-007444-c9vu8ako	358	35	where	where	WRB
cord-007444-c9vu8ako	358	36	most	most	JJS
cord-007444-c9vu8ako	358	37	COPD	COPD	NNP
cord-007444-c9vu8ako	358	38	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	358	39	are	be	VBP
cord-007444-c9vu8ako	358	40	Studies	study	NNS
cord-007444-c9vu8ako	358	41	of	of	IN
cord-007444-c9vu8ako	358	42	prognosis	prognosis	NN
cord-007444-c9vu8ako	358	43	in	in	IN
cord-007444-c9vu8ako	358	44	patients	patient	NNS
cord-007444-c9vu8ako	358	45	with	with	IN
cord-007444-c9vu8ako	358	46	COPD	COPD	NNP
cord-007444-c9vu8ako	358	47	and	and	CC
cord-007444-c9vu8ako	358	48	acute	acute	JJ
cord-007444-c9vu8ako	358	49	respiratory	respiratory	JJ
cord-007444-c9vu8ako	358	50	failure	failure	NN
cord-007444-c9vu8ako	358	51	performed	perform	VBN
cord-007444-c9vu8ako	358	52	during	during	IN
cord-007444-c9vu8ako	358	53	previous	previous	JJ
cord-007444-c9vu8ako	358	54	decades	decade	NNS
cord-007444-c9vu8ako	358	55	are	be	VBP
cord-007444-c9vu8ako	358	56	less	less	RBR
cord-007444-c9vu8ako	358	57	relevant	relevant	JJ
cord-007444-c9vu8ako	358	58	by	by	IN
cord-007444-c9vu8ako	358	59	today	today	NN
cord-007444-c9vu8ako	358	60	's	's	POS
cord-007444-c9vu8ako	358	61	standards	standard	NNS
cord-007444-c9vu8ako	358	62	.	.	.
cord-007444-c9vu8ako	359	1	Current	current	JJ
cord-007444-c9vu8ako	359	2	outcomes	outcome	NNS
cord-007444-c9vu8ako	359	3	appear	appear	VBP
cord-007444-c9vu8ako	359	4	to	to	TO
cord-007444-c9vu8ako	359	5	be	be	VB
cord-007444-c9vu8ako	359	6	better	well	JJR
cord-007444-c9vu8ako	359	7	than	than	IN
cord-007444-c9vu8ako	359	8	those	those	DT
cord-007444-c9vu8ako	359	9	of	of	IN
cord-007444-c9vu8ako	359	10	the	the	DT
cord-007444-c9vu8ako	359	11	past	past	NN
cord-007444-c9vu8ako	359	12	,	,	,
cord-007444-c9vu8ako	359	13	in	in	IN
cord-007444-c9vu8ako	359	14	part	part	NN
cord-007444-c9vu8ako	359	15	because	because	IN
cord-007444-c9vu8ako	359	16	of	of	IN
cord-007444-c9vu8ako	359	17	the	the	DT
cord-007444-c9vu8ako	359	18	widespread	widespread	JJ
cord-007444-c9vu8ako	359	19	use	use	NN
cord-007444-c9vu8ako	359	20	of	of	IN
cord-007444-c9vu8ako	359	21	controlled	control	VBN
cord-007444-c9vu8ako	359	22	Oz	Oz	NNP
cord-007444-c9vu8ako	359	23	therapy	therapy	NN
cord-007444-c9vu8ako	359	24	,	,	,
cord-007444-c9vu8ako	359	25	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	359	26	and	and	CC
cord-007444-c9vu8ako	359	27	IB	IB	NNP
cord-007444-c9vu8ako	359	28	,	,	,
cord-007444-c9vu8ako	359	29	availability	availability	NN
cord-007444-c9vu8ako	359	30	of	of	IN
cord-007444-c9vu8ako	359	31	better	well	JJR
cord-007444-c9vu8ako	359	32	p,-agonists	p,-agonist	NNS
cord-007444-c9vu8ako	359	33	,	,	,
cord-007444-c9vu8ako	359	34	reduced	reduce	VBN
cord-007444-c9vu8ako	359	35	use	use	NN
cord-007444-c9vu8ako	359	36	of	of	IN
cord-007444-c9vu8ako	359	37	methylxanthines	methylxanthine	NNS
cord-007444-c9vu8ako	359	38	,	,	,
cord-007444-c9vu8ako	359	39	and	and	CC
cord-007444-c9vu8ako	359	40	increased	increase	VBN
cord-007444-c9vu8ako	359	41	use	use	NN
cord-007444-c9vu8ako	359	42	of	of	IN
cord-007444-c9vu8ako	359	43	noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	359	44	ventilatory	ventilatory	NN
cord-007444-c9vu8ako	359	45	support.j3	support.j3	CD
cord-007444-c9vu8ako	360	1	Indeed	indeed	RB
cord-007444-c9vu8ako	360	2	,	,	,
cord-007444-c9vu8ako	360	3	there	there	EX
cord-007444-c9vu8ako	360	4	is	be	VBZ
cord-007444-c9vu8ako	360	5	evidence	evidence	NN
cord-007444-c9vu8ako	360	6	to	to	TO
cord-007444-c9vu8ako	360	7	support	support	VB
cord-007444-c9vu8ako	360	8	a	a	DT
cord-007444-c9vu8ako	360	9	trend	trend	NN
cord-007444-c9vu8ako	360	10	toward	toward	IN
cord-007444-c9vu8ako	360	11	improved	improve	VBN
cord-007444-c9vu8ako	360	12	survival	survival	NN
cord-007444-c9vu8ako	360	13	for	for	IN
cord-007444-c9vu8ako	360	14	hypercapnic	hypercapnic	NNP
cord-007444-c9vu8ako	360	15	respiratory	respiratory	JJ
cord-007444-c9vu8ako	360	16	failure	failure	NN
cord-007444-c9vu8ako	360	17	over	over	IN
cord-007444-c9vu8ako	360	18	the	the	DT
cord-007444-c9vu8ako	360	19	past	past	JJ
cord-007444-c9vu8ako	360	20	20	20	CD
cord-007444-c9vu8ako	360	21	years	year	NNS
cord-007444-c9vu8ako	360	22	.	.	.
cord-007444-c9vu8ako	361	1	The	the	DT
cord-007444-c9vu8ako	361	2	mortality	mortality	NN
cord-007444-c9vu8ako	361	3	rates	rate	NNS
cord-007444-c9vu8ako	361	4	in	in	IN
cord-007444-c9vu8ako	361	5	studies	study	NNS
cord-007444-c9vu8ako	361	6	of	of	IN
cord-007444-c9vu8ako	361	7	survival	survival	NN
cord-007444-c9vu8ako	361	8	of	of	IN
cord-007444-c9vu8ako	361	9	acute	acute	JJ
cord-007444-c9vu8ako	361	10	respiratory	respiratory	JJ
cord-007444-c9vu8ako	361	11	failure	failure	NN
cord-007444-c9vu8ako	361	12	in	in	IN
cord-007444-c9vu8ako	361	13	COPD	COPD	NNP
cord-007444-c9vu8ako	361	14	conducted	conduct	VBN
cord-007444-c9vu8ako	361	15	from	from	IN
cord-007444-c9vu8ako	361	16	1968	1968	CD
cord-007444-c9vu8ako	361	17	to	to	IN
cord-007444-c9vu8ako	361	18	1973	1973	CD
cord-007444-c9vu8ako	361	19	ranged	range	VBD
cord-007444-c9vu8ako	361	20	from	from	IN
cord-007444-c9vu8ako	361	21	22	22	CD
cord-007444-c9vu8ako	361	22	%	%	NN
cord-007444-c9vu8ako	361	23	to	to	IN
cord-007444-c9vu8ako	361	24	34	34	CD
cord-007444-c9vu8ako	361	25	%	%	NN
cord-007444-c9vu8ako	361	26	,	,	,
cord-007444-c9vu8ako	361	27	with	with	IN
cord-007444-c9vu8ako	361	28	an	an	DT
cord-007444-c9vu8ako	361	29	overall	overall	JJ
cord-007444-c9vu8ako	361	30	mortality	mortality	NN
cord-007444-c9vu8ako	361	31	of	of	IN
cord-007444-c9vu8ako	361	32	26	26	CD
cord-007444-c9vu8ako	361	33	%	%	NN
cord-007444-c9vu8ako	361	34	.	.	.
cord-007444-c9vu8ako	362	1	For	for	IN
cord-007444-c9vu8ako	362	2	similar	similar	JJ
cord-007444-c9vu8ako	362	3	studies	study	NNS
cord-007444-c9vu8ako	362	4	between	between	IN
cord-007444-c9vu8ako	362	5	1978	1978	CD
cord-007444-c9vu8ako	362	6	and	and	CC
cord-007444-c9vu8ako	362	7	1992	1992	CD
cord-007444-c9vu8ako	362	8	,	,	,
cord-007444-c9vu8ako	362	9	the	the	DT
cord-007444-c9vu8ako	362	10	range	range	NN
cord-007444-c9vu8ako	362	11	is	be	VBZ
cord-007444-c9vu8ako	362	12	6	6	CD
cord-007444-c9vu8ako	362	13	%	%	NN
cord-007444-c9vu8ako	362	14	to	to	TO
cord-007444-c9vu8ako	362	15	12	12	CD
cord-007444-c9vu8ako	362	16	%	%	NN
cord-007444-c9vu8ako	362	17	,	,	,
cord-007444-c9vu8ako	362	18	with	with	IN
cord-007444-c9vu8ako	362	19	an	an	DT
cord-007444-c9vu8ako	362	20	overall	overall	JJ
cord-007444-c9vu8ako	362	21	mortality	mortality	NN
cord-007444-c9vu8ako	362	22	The	the	DT
cord-007444-c9vu8ako	362	23	most	most	RBS
cord-007444-c9vu8ako	362	24	recent	recent	JJ
cord-007444-c9vu8ako	362	25	and	and	CC
cord-007444-c9vu8ako	362	26	comprehensive	comprehensive	JJ
cord-007444-c9vu8ako	362	27	evaluation	evaluation	NN
cord-007444-c9vu8ako	362	28	of	of	IN
cord-007444-c9vu8ako	362	29	outcomes	outcome	NNS
cord-007444-c9vu8ako	362	30	following	follow	VBG
cord-007444-c9vu8ako	362	31	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	362	32	was	be	VBD
cord-007444-c9vu8ako	362	33	published	publish	VBN
cord-007444-c9vu8ako	362	34	by	by	IN
cord-007444-c9vu8ako	362	35	Connors	Connors	NNP
cord-007444-c9vu8ako	362	36	et	et	NNP
cord-007444-c9vu8ako	362	37	a1	a1	NNP
cord-007444-c9vu8ako	362	38	as	as	IN
cord-007444-c9vu8ako	362	39	a	a	DT
cord-007444-c9vu8ako	362	40	component	component	NN
cord-007444-c9vu8ako	362	41	of	of	IN
cord-007444-c9vu8ako	362	42	the	the	DT
cord-007444-c9vu8ako	362	43	landmark	landmark	JJ
cord-007444-c9vu8ako	362	44	Study	Study	NNP
cord-007444-c9vu8ako	362	45	to	to	TO
cord-007444-c9vu8ako	362	46	Understand	understand	VB
cord-007444-c9vu8ako	362	47	Prognoses	prognosis	NNS
cord-007444-c9vu8ako	362	48	for	for	IN
cord-007444-c9vu8ako	362	49	Outcomes	outcome	NNS
cord-007444-c9vu8ako	362	50	and	and	CC
cord-007444-c9vu8ako	362	51	Risks	risk	NNS
cord-007444-c9vu8ako	362	52	of	of	IN
cord-007444-c9vu8ako	362	53	Treatment	treatment	NN
cord-007444-c9vu8ako	362	54	(	(	-LRB-
cord-007444-c9vu8ako	362	55	SUPPORT	SUPPORT	NNP
cord-007444-c9vu8ako	362	56	)	)	-RRB-
cord-007444-c9vu8ako	363	1	They	-PRON-	PRP
cord-007444-c9vu8ako	363	2	prospectively	prospectively	RB
cord-007444-c9vu8ako	363	3	studied	study	VBD
cord-007444-c9vu8ako	363	4	more	more	JJR
cord-007444-c9vu8ako	363	5	than	than	IN
cord-007444-c9vu8ako	363	6	1000	1000	CD
cord-007444-c9vu8ako	363	7	patients	patient	NNS
cord-007444-c9vu8ako	363	8	admitted	admit	VBN
cord-007444-c9vu8ako	363	9	to	to	IN
cord-007444-c9vu8ako	363	10	five	five	CD
cord-007444-c9vu8ako	363	11	US	US	NNP
cord-007444-c9vu8ako	363	12	tertiary	tertiary	JJ
cord-007444-c9vu8ako	363	13	care	care	NN
cord-007444-c9vu8ako	363	14	hospitals	hospital	NNS
cord-007444-c9vu8ako	363	15	with	with	IN
cord-007444-c9vu8ako	363	16	severe	severe	JJ
cord-007444-c9vu8ako	363	17	hypercarbic	hypercarbic	JJ
cord-007444-c9vu8ako	363	18	COPD	COPD	NNP
cord-007444-c9vu8ako	363	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	363	20	(	(	-LRB-
cord-007444-c9vu8ako	363	21	initial	initial	JJ
cord-007444-c9vu8ako	363	22	Paco,~50	paco,~50	NN
cord-007444-c9vu8ako	363	23	mm	mm	CD
cord-007444-c9vu8ako	363	24	Hg	Hg	NNP
cord-007444-c9vu8ako	363	25	)	)	-RRB-
cord-007444-c9vu8ako	363	26	.	.	.
cord-007444-c9vu8ako	364	1	Baseline	Baseline	NNP
cord-007444-c9vu8ako	364	2	FEV	FEV	NNP
cord-007444-c9vu8ako	364	3	,	,	,
cord-007444-c9vu8ako	364	4	was	be	VBD
cord-007444-c9vu8ako	364	5	not	not	RB
cord-007444-c9vu8ako	364	6	available	available	JJ
cord-007444-c9vu8ako	364	7	for	for	IN
cord-007444-c9vu8ako	364	8	most	most	JJS
cord-007444-c9vu8ako	364	9	patients	patient	NNS
cord-007444-c9vu8ako	364	10	.	.	.
cord-007444-c9vu8ako	365	1	Half	half	PDT
cord-007444-c9vu8ako	365	2	the	the	DT
cord-007444-c9vu8ako	365	3	patients	patient	NNS
cord-007444-c9vu8ako	365	4	required	require	VBD
cord-007444-c9vu8ako	365	5	intensive	intensive	JJ
cord-007444-c9vu8ako	365	6	care	care	NN
cord-007444-c9vu8ako	365	7	unit	unit	NN
cord-007444-c9vu8ako	365	8	admission	admission	NN
cord-007444-c9vu8ako	365	9	and	and	CC
cord-007444-c9vu8ako	365	10	35	35	CD
cord-007444-c9vu8ako	365	11	%	%	NN
cord-007444-c9vu8ako	365	12	required	require	VBN
cord-007444-c9vu8ako	365	13	mechanical	mechanical	JJ
cord-007444-c9vu8ako	365	14	ventilation	ventilation	NN
cord-007444-c9vu8ako	365	15	.	.	.
cord-007444-c9vu8ako	366	1	Hospital	hospital	NN
cord-007444-c9vu8ako	366	2	mortality	mortality	NN
cord-007444-c9vu8ako	366	3	was	be	VBD
cord-007444-c9vu8ako	366	4	11	11	CD
cord-007444-c9vu8ako	366	5	%	%	NN
cord-007444-c9vu8ako	366	6	.	.	.
cord-007444-c9vu8ako	367	1	More	more	RBR
cord-007444-c9vu8ako	367	2	striking	striking	JJ
cord-007444-c9vu8ako	367	3	,	,	,
cord-007444-c9vu8ako	367	4	however	however	RB
cord-007444-c9vu8ako	367	5	,	,	,
cord-007444-c9vu8ako	367	6	was	be	VBD
cord-007444-c9vu8ako	367	7	the	the	DT
cord-007444-c9vu8ako	367	8	finding	finding	NN
cord-007444-c9vu8ako	367	9	that	that	IN
cord-007444-c9vu8ako	367	10	following	follow	VBG
cord-007444-c9vu8ako	367	11	discharge	discharge	NN
cord-007444-c9vu8ako	367	12	,	,	,
cord-007444-c9vu8ako	367	13	one	one	CD
cord-007444-c9vu8ako	367	14	third	third	NN
cord-007444-c9vu8ako	367	15	of	of	IN
cord-007444-c9vu8ako	367	16	the	the	DT
cord-007444-c9vu8ako	367	17	patients	patient	NNS
cord-007444-c9vu8ako	367	18	died	die	VBD
cord-007444-c9vu8ako	367	19	in	in	IN
cord-007444-c9vu8ako	367	20	within	within	IN
cord-007444-c9vu8ako	367	21	6	6	CD
cord-007444-c9vu8ako	367	22	months	month	NNS
cord-007444-c9vu8ako	367	23	and	and	CC
cord-007444-c9vu8ako	367	24	one	one	CD
cord-007444-c9vu8ako	367	25	half	half	NN
cord-007444-c9vu8ako	367	26	within	within	IN
cord-007444-c9vu8ako	367	27	2	2	CD
cord-007444-c9vu8ako	367	28	years	year	NNS
cord-007444-c9vu8ako	367	29	.	.	.
cord-007444-c9vu8ako	368	1	Not	not	RB
cord-007444-c9vu8ako	368	2	surprisingly	surprisingly	RB
cord-007444-c9vu8ako	368	3	,	,	,
cord-007444-c9vu8ako	368	4	patients	patient	NNS
cord-007444-c9vu8ako	368	5	who	who	WP
cord-007444-c9vu8ako	368	6	survived	survive	VBD
cord-007444-c9vu8ako	368	7	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	368	8	had	have	VBD
cord-007444-c9vu8ako	368	9	a	a	DT
cord-007444-c9vu8ako	368	10	substantial	substantial	JJ
cord-007444-c9vu8ako	368	11	risk	risk	NN
cord-007444-c9vu8ako	368	12	of	of	IN
cord-007444-c9vu8ako	368	13	discharge	discharge	NN
cord-007444-c9vu8ako	368	14	to	to	IN
cord-007444-c9vu8ako	368	15	a	a	DT
cord-007444-c9vu8ako	368	16	facility	facility	NN
cord-007444-c9vu8ako	368	17	other	other	JJ
cord-007444-c9vu8ako	368	18	than	than	IN
cord-007444-c9vu8ako	368	19	their	-PRON-	PRP$
cord-007444-c9vu8ako	368	20	home	home	NN
cord-007444-c9vu8ako	368	21	(	(	-LRB-
cord-007444-c9vu8ako	368	22	20	20	CD
cord-007444-c9vu8ako	368	23	%	%	NN
cord-007444-c9vu8ako	368	24	)	)	-RRB-
cord-007444-c9vu8ako	368	25	and	and	CC
cord-007444-c9vu8ako	368	26	of	of	IN
cord-007444-c9vu8ako	368	27	readmission	readmission	NN
cord-007444-c9vu8ako	368	28	to	to	IN
cord-007444-c9vu8ako	368	29	acute	acute	JJ
cord-007444-c9vu8ako	368	30	care	care	NN
cord-007444-c9vu8ako	368	31	over	over	IN
cord-007444-c9vu8ako	368	32	the	the	DT
cord-007444-c9vu8ako	368	33	ensuing	ensue	VBG
cord-007444-c9vu8ako	368	34	6	6	CD
cord-007444-c9vu8ako	368	35	months	month	NNS
cord-007444-c9vu8ako	368	36	(	(	-LRB-
cord-007444-c9vu8ako	368	37	50	50	CD
cord-007444-c9vu8ako	368	38	%	%	NN
cord-007444-c9vu8ako	368	39	)	)	-RRB-
cord-007444-c9vu8ako	368	40	.	.	.
cord-007444-c9vu8ako	369	1	Higher	high	JJR
cord-007444-c9vu8ako	369	2	acute	acute	JJ
cord-007444-c9vu8ako	369	3	physiology	physiology	NN
cord-007444-c9vu8ako	369	4	score	score	NN
cord-007444-c9vu8ako	369	5	(	(	-LRB-
cord-007444-c9vu8ako	369	6	Acute	Acute	NNP
cord-007444-c9vu8ako	369	7	Physiology	Physiology	NNP
cord-007444-c9vu8ako	369	8	and	and	CC
cord-007444-c9vu8ako	369	9	Chronic	Chronic	NNP
cord-007444-c9vu8ako	369	10	Health	Health	NNP
cord-007444-c9vu8ako	369	11	Evaluation	Evaluation	NNP
cord-007444-c9vu8ako	369	12	;	;	:
cord-007444-c9vu8ako	369	13	APACHE	APACHE	NNP
cord-007444-c9vu8ako	369	14	111	111	CD
cord-007444-c9vu8ako	369	15	)	)	-RRB-
cord-007444-c9vu8ako	369	16	,	,	,
cord-007444-c9vu8ako	369	17	older	old	JJR
cord-007444-c9vu8ako	369	18	age	age	NN
cord-007444-c9vu8ako	369	19	,	,	,
cord-007444-c9vu8ako	369	20	and	and	CC
cord-007444-c9vu8ako	369	21	poor	poor	JJ
cord-007444-c9vu8ako	369	22	functional	functional	JJ
cord-007444-c9vu8ako	369	23	status	status	NN
cord-007444-c9vu8ako	369	24	prior	prior	RB
cord-007444-c9vu8ako	369	25	to	to	IN
cord-007444-c9vu8ako	369	26	admission	admission	NN
cord-007444-c9vu8ako	369	27	independently	independently	RB
cord-007444-c9vu8ako	369	28	increased	increase	VBN
cord-007444-c9vu8ako	369	29	risk	risk	NN
cord-007444-c9vu8ako	369	30	of	of	IN
cord-007444-c9vu8ako	369	31	death	death	NN
cord-007444-c9vu8ako	369	32	.	.	.
cord-007444-c9vu8ako	370	1	Improved	improve	VBN
cord-007444-c9vu8ako	370	2	survival	survival	NN
cord-007444-c9vu8ako	370	3	was	be	VBD
cord-007444-c9vu8ako	370	4	of	of	IN
cord-007444-c9vu8ako	370	5	10%.132	10%.132	CD
cord-007444-c9vu8ako	370	6	predicted	predict	VBN
cord-007444-c9vu8ako	370	7	by	by	IN
cord-007444-c9vu8ako	370	8	greater	great	JJR
cord-007444-c9vu8ako	370	9	BMI	BMI	NNP
cord-007444-c9vu8ako	370	10	and	and	CC
cord-007444-c9vu8ako	370	11	albumin	albumin	NN
cord-007444-c9vu8ako	370	12	level	level	NN
cord-007444-c9vu8ako	370	13	,	,	,
cord-007444-c9vu8ako	370	14	higher	high	JJR
cord-007444-c9vu8ako	370	15	Paoz	Paoz	NNP
cord-007444-c9vu8ako	370	16	/	/	SYM
cord-007444-c9vu8ako	370	17	Fio	Fio	NNP
cord-007444-c9vu8ako	370	18	,	,	,
cord-007444-c9vu8ako	370	19	and	and	CC
cord-007444-c9vu8ako	370	20	,	,	,
cord-007444-c9vu8ako	370	21	surprisingly	surprisingly	RB
cord-007444-c9vu8ako	370	22	,	,	,
cord-007444-c9vu8ako	370	23	the	the	DT
cord-007444-c9vu8ako	370	24	presence	presence	NN
cord-007444-c9vu8ako	370	25	of	of	IN
cord-007444-c9vu8ako	370	26	cor	cor	NNP
cord-007444-c9vu8ako	370	27	pulmonale	pulmonale	NNP
cord-007444-c9vu8ako	370	28	and	and	CC
cord-007444-c9vu8ako	370	29	congestive	congestive	JJ
cord-007444-c9vu8ako	370	30	heart	heart	NN
cord-007444-c9vu8ako	370	31	failure	failure	NN
cord-007444-c9vu8ako	370	32	as	as	IN
cord-007444-c9vu8ako	370	33	the	the	DT
cord-007444-c9vu8ako	370	34	cause	cause	NN
cord-007444-c9vu8ako	370	35	of	of	IN
cord-007444-c9vu8ako	370	36	the	the	DT
cord-007444-c9vu8ako	370	37	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	370	38	.	.	.
cord-007444-c9vu8ako	371	1	The	the	DT
cord-007444-c9vu8ako	371	2	latter	latter	JJ
cord-007444-c9vu8ako	371	3	findings	finding	NNS
cord-007444-c9vu8ako	371	4	may	may	MD
cord-007444-c9vu8ako	371	5	be	be	VB
cord-007444-c9vu8ako	371	6	explained	explain	VBN
cord-007444-c9vu8ako	371	7	by	by	IN
cord-007444-c9vu8ako	371	8	the	the	DT
cord-007444-c9vu8ako	371	9	good	good	JJ
cord-007444-c9vu8ako	371	10	response	response	NN
cord-007444-c9vu8ako	371	11	of	of	IN
cord-007444-c9vu8ako	371	12	these	these	DT
cord-007444-c9vu8ako	371	13	two	two	CD
cord-007444-c9vu8ako	371	14	disorders	disorder	NNS
cord-007444-c9vu8ako	371	15	to	to	IN
cord-007444-c9vu8ako	371	16	acute	acute	JJ
cord-007444-c9vu8ako	371	17	therapy	therapy	NN
cord-007444-c9vu8ako	371	18	.	.	.
cord-007444-c9vu8ako	372	1	also	also	RB
cord-007444-c9vu8ako	372	2	supports	support	VBZ
cord-007444-c9vu8ako	372	3	the	the	DT
cord-007444-c9vu8ako	372	4	finding	finding	NN
cord-007444-c9vu8ako	372	5	that	that	IN
cord-007444-c9vu8ako	372	6	host	host	NN
cord-007444-c9vu8ako	372	7	factors	factor	NNS
cord-007444-c9vu8ako	372	8	are	be	VBP
cord-007444-c9vu8ako	372	9	principal	principal	JJ
cord-007444-c9vu8ako	372	10	determinants	determinant	NNS
cord-007444-c9vu8ako	372	11	of	of	IN
cord-007444-c9vu8ako	372	12	outcomes	outcome	NNS
cord-007444-c9vu8ako	372	13	of	of	IN
cord-007444-c9vu8ako	372	14	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	372	15	.	.	.
cord-007444-c9vu8ako	373	1	In	in	IN
cord-007444-c9vu8ako	373	2	their	-PRON-	PRP$
cord-007444-c9vu8ako	373	3	retrospective	retrospective	JJ
cord-007444-c9vu8ako	373	4	analysis	analysis	NN
cord-007444-c9vu8ako	373	5	of	of	IN
cord-007444-c9vu8ako	373	6	232	232	CD
cord-007444-c9vu8ako	373	7	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	373	8	in	in	IN
cord-007444-c9vu8ako	373	9	107	107	CD
cord-007444-c9vu8ako	373	10	patients	patient	NNS
cord-007444-c9vu8ako	373	11	with	with	IN
cord-007444-c9vu8ako	373	12	COPD	COPD	NNP
cord-007444-c9vu8ako	373	13	,	,	,
cord-007444-c9vu8ako	373	14	severity	severity	NN
cord-007444-c9vu8ako	373	15	of	of	IN
cord-007444-c9vu8ako	373	16	airflow	airflow	NN
cord-007444-c9vu8ako	373	17	obstruction	obstruction	NN
cord-007444-c9vu8ako	373	18	,	,	,
cord-007444-c9vu8ako	373	19	use	use	NN
cord-007444-c9vu8ako	373	20	of	of	IN
cord-007444-c9vu8ako	373	21	home	home	NN
cord-007444-c9vu8ako	373	22	0	0	CD
cord-007444-c9vu8ako	373	23	,	,	,
cord-007444-c9vu8ako	373	24	frequency	frequency	NN
cord-007444-c9vu8ako	373	25	of	of	IN
cord-007444-c9vu8ako	373	26	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	373	27	,	,	,
cord-007444-c9vu8ako	373	28	history	history	NN
cord-007444-c9vu8ako	373	29	of	of	IN
cord-007444-c9vu8ako	373	30	previous	previous	JJ
cord-007444-c9vu8ako	373	31	pneumonia	pneumonia	NN
cord-007444-c9vu8ako	373	32	or	or	CC
cord-007444-c9vu8ako	373	33	sinusitis	sinusitis	NN
cord-007444-c9vu8ako	373	34	,	,	,
cord-007444-c9vu8ako	373	35	and	and	CC
cord-007444-c9vu8ako	373	36	use	use	NN
cord-007444-c9vu8ako	373	37	of	of	IN
cord-007444-c9vu8ako	373	38	maintenance	maintenance	NN
cord-007444-c9vu8ako	373	39	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	373	40	each	each	DT
cord-007444-c9vu8ako	373	41	were	be	VBD
cord-007444-c9vu8ako	373	42	independently	independently	RB
cord-007444-c9vu8ako	373	43	associated	associate	VBN
cord-007444-c9vu8ako	373	44	with	with	IN
cord-007444-c9vu8ako	373	45	treatment	treatment	NN
cord-007444-c9vu8ako	373	46	failure	failure	NN
cord-007444-c9vu8ako	373	47	.	.	.
cord-007444-c9vu8ako	374	1	Surprisingly	surprisingly	RB
cord-007444-c9vu8ako	374	2	,	,	,
cord-007444-c9vu8ako	374	3	age	age	NN
cord-007444-c9vu8ako	374	4	,	,	,
cord-007444-c9vu8ako	374	5	choice	choice	NN
cord-007444-c9vu8ako	374	6	of	of	IN
cord-007444-c9vu8ako	374	7	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	374	8	,	,	,
cord-007444-c9vu8ako	374	9	and	and	CC
cord-007444-c9vu8ako	374	10	presence	presence	NN
cord-007444-c9vu8ako	374	11	of	of	IN
cord-007444-c9vu8ako	374	12	comorbid	comorbid	NN
cord-007444-c9vu8ako	374	13	conditions	condition	NNS
cord-007444-c9vu8ako	374	14	did	do	VBD
cord-007444-c9vu8ako	374	15	not	not	RB
cord-007444-c9vu8ako	374	16	affect	affect	VB
cord-007444-c9vu8ako	374	17	the	the	DT
cord-007444-c9vu8ako	374	18	treatment	treatment	NN
cord-007444-c9vu8ako	374	19	outcome	outcome	NN
cord-007444-c9vu8ako	374	20	in	in	IN
cord-007444-c9vu8ako	374	21	that	that	DT
cord-007444-c9vu8ako	374	22	study	study	NN
cord-007444-c9vu8ako	374	23	.	.	.
cord-007444-c9vu8ako	375	1	Several	several	JJ
cord-007444-c9vu8ako	375	2	investigators6z	investigators6z	NNP
cord-007444-c9vu8ako	375	3	78	78	CD
cord-007444-c9vu8ako	375	4	,	,	,
cord-007444-c9vu8ako	375	5	l	l	NNP
cord-007444-c9vu8ako	375	6	oo	oo	UH
cord-007444-c9vu8ako	375	7	,	,	,
cord-007444-c9vu8ako	375	8	Iw	iw	PRP
cord-007444-c9vu8ako	375	9	have	have	VBP
cord-007444-c9vu8ako	375	10	evaluated	evaluate	VBN
cord-007444-c9vu8ako	375	11	the	the	DT
cord-007444-c9vu8ako	375	12	prognosis	prognosis	NN
cord-007444-c9vu8ako	375	13	of	of	IN
cord-007444-c9vu8ako	375	14	patients	patient	NNS
cord-007444-c9vu8ako	375	15	with	with	IN
cord-007444-c9vu8ako	375	16	COPD	COPD	NNP
cord-007444-c9vu8ako	375	17	who	who	WP
cord-007444-c9vu8ako	375	18	require	require	VBP
cord-007444-c9vu8ako	375	19	ICU	ICU	NNP
cord-007444-c9vu8ako	375	20	admission	admission	NN
cord-007444-c9vu8ako	375	21	for	for	IN
cord-007444-c9vu8ako	375	22	acute	acute	JJ
cord-007444-c9vu8ako	375	23	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	375	24	.	.	.
cord-007444-c9vu8ako	376	1	The	the	DT
cord-007444-c9vu8ako	376	2	results	result	NNS
cord-007444-c9vu8ako	376	3	have	have	VBP
cord-007444-c9vu8ako	376	4	been	be	VBN
cord-007444-c9vu8ako	376	5	somewhat	somewhat	RB
cord-007444-c9vu8ako	376	6	contradictory	contradictory	JJ
cord-007444-c9vu8ako	376	7	.	.	.
cord-007444-c9vu8ako	377	1	Kaelin	Kaelin	NNP
cord-007444-c9vu8ako	377	2	et	et	NNP
cord-007444-c9vu8ako	378	1	a1,6z	a1,6z	NNP
cord-007444-c9vu8ako	378	2	for	for	IN
cord-007444-c9vu8ako	378	3	example	example	NN
cord-007444-c9vu8ako	378	4	,	,	,
cord-007444-c9vu8ako	378	5	using	use	VBG
cord-007444-c9vu8ako	378	6	several	several	JJ
cord-007444-c9vu8ako	378	7	easily	easily	RB
cord-007444-c9vu8ako	378	8	obtainable	obtainable	JJ
cord-007444-c9vu8ako	378	9	indices	index	NNS
cord-007444-c9vu8ako	378	10	,	,	,
cord-007444-c9vu8ako	378	11	were	be	VBD
cord-007444-c9vu8ako	378	12	unable	unable	JJ
cord-007444-c9vu8ako	378	13	to	to	TO
cord-007444-c9vu8ako	378	14	discriminate	discriminate	VB
cord-007444-c9vu8ako	378	15	between	between	IN
cord-007444-c9vu8ako	378	16	patients	patient	NNS
cord-007444-c9vu8ako	378	17	surviving	survive	VBG
cord-007444-c9vu8ako	378	18	more	more	RBR
cord-007444-c9vu8ako	378	19	or	or	CC
cord-007444-c9vu8ako	378	20	less	less	JJR
cord-007444-c9vu8ako	378	21	than	than	IN
cord-007444-c9vu8ako	378	22	6	6	CD
cord-007444-c9vu8ako	378	23	months	month	NNS
cord-007444-c9vu8ako	378	24	following	follow	VBG
cord-007444-c9vu8ako	378	25	intubation	intubation	NN
cord-007444-c9vu8ako	378	26	.	.	.
cord-007444-c9vu8ako	379	1	In	in	IN
cord-007444-c9vu8ako	379	2	their	-PRON-	PRP$
cord-007444-c9vu8ako	379	3	analysis	analysis	NN
cord-007444-c9vu8ako	379	4	of	of	IN
cord-007444-c9vu8ako	379	5	39	39	CD
cord-007444-c9vu8ako	379	6	consecutive	consecutive	JJ
cord-007444-c9vu8ako	379	7	acute	acute	JJ
cord-007444-c9vu8ako	379	8	COPD	COPD	NNP
cord-007444-c9vu8ako	379	9	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	379	10	,	,	,
cord-007444-c9vu8ako	379	11	neither	neither	CC
cord-007444-c9vu8ako	379	12	age	age	NN
cord-007444-c9vu8ako	379	13	nor	nor	CC
cord-007444-c9vu8ako	379	14	spirometric	spirometric	NN
cord-007444-c9vu8ako	379	15	,	,	,
cord-007444-c9vu8ako	379	16	blood	blood	NN
cord-007444-c9vu8ako	379	17	gas	gas	NN
cord-007444-c9vu8ako	379	18	,	,	,
cord-007444-c9vu8ako	379	19	or	or	CC
cord-007444-c9vu8ako	379	20	nutritional	nutritional	JJ
cord-007444-c9vu8ako	379	21	indices	index	NNS
cord-007444-c9vu8ako	379	22	predicted	predict	VBD
cord-007444-c9vu8ako	379	23	survival	survival	NN
cord-007444-c9vu8ako	379	24	.	.	.
cord-007444-c9vu8ako	380	1	In	in	IN
cord-007444-c9vu8ako	380	2	contrast	contrast	NN
cord-007444-c9vu8ako	380	3	,	,	,
cord-007444-c9vu8ako	380	4	Menzies	Menzies	NNP
cord-007444-c9vu8ako	380	5	et	et	NNP
cord-007444-c9vu8ako	380	6	a17	a17	NNP
cord-007444-c9vu8ako	380	7	*	*	NFP
cord-007444-c9vu8ako	380	8	reported	report	VBD
cord-007444-c9vu8ako	380	9	that	that	IN
cord-007444-c9vu8ako	380	10	,	,	,
cord-007444-c9vu8ako	380	11	among	among	IN
cord-007444-c9vu8ako	380	12	their	-PRON-	PRP$
cord-007444-c9vu8ako	380	13	95	95	CD
cord-007444-c9vu8ako	380	14	patients	patient	NNS
cord-007444-c9vu8ako	380	15	,	,	,
cord-007444-c9vu8ako	380	16	higher	high	JJR
cord-007444-c9vu8ako	380	17	baseline	baseline	JJ
cord-007444-c9vu8ako	380	18	FEV	FEV	NNP
cord-007444-c9vu8ako	380	19	,	,	,
cord-007444-c9vu8ako	380	20	and	and	CC
cord-007444-c9vu8ako	380	21	serum	serum	NN
cord-007444-c9vu8ako	380	22	albumin	albumin	NN
cord-007444-c9vu8ako	380	23	were	be	VBD
cord-007444-c9vu8ako	380	24	significantly	significantly	RB
cord-007444-c9vu8ako	380	25	associated	associate	VBN
cord-007444-c9vu8ako	380	26	with	with	IN
cord-007444-c9vu8ako	380	27	improved	improve	VBN
cord-007444-c9vu8ako	380	28	1-year	1-year	CD
cord-007444-c9vu8ako	380	29	survival	survival	NN
cord-007444-c9vu8ako	380	30	following	follow	VBG
cord-007444-c9vu8ako	380	31	mechanical	mechanical	JJ
cord-007444-c9vu8ako	380	32	ventilation	ventilation	NN
cord-007444-c9vu8ako	380	33	.	.	.
cord-007444-c9vu8ako	381	1	These	these	DT
cord-007444-c9vu8ako	381	2	contradictory	contradictory	JJ
cord-007444-c9vu8ako	381	3	findings	finding	NNS
cord-007444-c9vu8ako	381	4	are	be	VBP
cord-007444-c9vu8ako	381	5	especially	especially	RB
cord-007444-c9vu8ako	381	6	curious	curious	JJ
cord-007444-c9vu8ako	381	7	given	give	VBN
cord-007444-c9vu8ako	381	8	that	that	IN
cord-007444-c9vu8ako	381	9	both	both	DT
cord-007444-c9vu8ako	381	10	studies	study	NNS
cord-007444-c9vu8ako	381	11	had	have	VBD
cord-007444-c9vu8ako	381	12	similar	similar	JJ
cord-007444-c9vu8ako	381	13	inclusion	inclusion	NN
cord-007444-c9vu8ako	381	14	and	and	CC
cord-007444-c9vu8ako	381	15	exclusion	exclusion	NN
cord-007444-c9vu8ako	381	16	criteria	criterion	NNS
cord-007444-c9vu8ako	381	17	and	and	CC
cord-007444-c9vu8ako	381	18	periods	period	NNS
cord-007444-c9vu8ako	381	19	of	of	IN
cord-007444-c9vu8ako	381	20	observation	observation	NN
cord-007444-c9vu8ako	381	21	.	.	.
cord-007444-c9vu8ako	382	1	Moreover	moreover	RB
cord-007444-c9vu8ako	382	2	,	,	,
cord-007444-c9vu8ako	382	3	their	-PRON-	PRP$
cord-007444-c9vu8ako	382	4	populations	population	NNS
cord-007444-c9vu8ako	382	5	both	both	DT
cord-007444-c9vu8ako	382	6	had	have	VBD
cord-007444-c9vu8ako	382	7	a	a	DT
cord-007444-c9vu8ako	382	8	mean	mean	JJ
cord-007444-c9vu8ako	382	9	percent	percent	NN
cord-007444-c9vu8ako	382	10	-	-	HYPH
cord-007444-c9vu8ako	382	11	predicted	predict	VBN
cord-007444-c9vu8ako	382	12	FEV	FEV	NNP
cord-007444-c9vu8ako	382	13	,	,	,
cord-007444-c9vu8ako	382	14	of	of	IN
cord-007444-c9vu8ako	382	15	35	35	CD
cord-007444-c9vu8ako	382	16	%	%	NN
cord-007444-c9vu8ako	382	17	and	and	CC
cord-007444-c9vu8ako	382	18	nearly	nearly	RB
cord-007444-c9vu8ako	382	19	identical	identical	JJ
cord-007444-c9vu8ako	382	20	baseline	baseline	JJ
cord-007444-c9vu8ako	382	21	values	value	NNS
cord-007444-c9vu8ako	382	22	for	for	IN
cord-007444-c9vu8ako	382	23	serum	serum	NN
cord-007444-c9vu8ako	382	24	albumin	albumin	NN
cord-007444-c9vu8ako	382	25	.	.	.
cord-007444-c9vu8ako	383	1	More	more	RBR
cord-007444-c9vu8ako	383	2	recently	recently	RB
cord-007444-c9vu8ako	383	3	,	,	,
cord-007444-c9vu8ako	383	4	Rieves	Rieves	NNP
cord-007444-c9vu8ako	383	5	et	et	NNP
cord-007444-c9vu8ako	383	6	alloo	alloo	NNP
cord-007444-c9vu8ako	383	7	tried	try	VBD
cord-007444-c9vu8ako	383	8	to	to	TO
cord-007444-c9vu8ako	383	9	identify	identify	VB
cord-007444-c9vu8ako	383	10	clinically	clinically	RB
cord-007444-c9vu8ako	383	11	useful	useful	JJ
cord-007444-c9vu8ako	383	12	variables	variable	NNS
cord-007444-c9vu8ako	383	13	that	that	WDT
cord-007444-c9vu8ako	383	14	predict	predict	VBP
cord-007444-c9vu8ako	383	15	successful	successful	JJ
cord-007444-c9vu8ako	383	16	weaning	weaning	NN
cord-007444-c9vu8ako	383	17	from	from	IN
cord-007444-c9vu8ako	383	18	mechanical	mechanical	JJ
cord-007444-c9vu8ako	383	19	ventilation	ventilation	NN
cord-007444-c9vu8ako	383	20	and	and	CC
cord-007444-c9vu8ako	383	21	shortterm	shortterm	JJ
cord-007444-c9vu8ako	383	22	survival	survival	NN
cord-007444-c9vu8ako	383	23	in	in	IN
cord-007444-c9vu8ako	383	24	patients	patient	NNS
cord-007444-c9vu8ako	383	25	with	with	IN
cord-007444-c9vu8ako	383	26	COPD	COPD	NNP
cord-007444-c9vu8ako	383	27	with	with	IN
cord-007444-c9vu8ako	383	28	acute	acute	JJ
cord-007444-c9vu8ako	383	29	respiratory	respiratory	JJ
cord-007444-c9vu8ako	383	30	failure	failure	NN
cord-007444-c9vu8ako	383	31	.	.	.
cord-007444-c9vu8ako	384	1	They	-PRON-	PRP
cord-007444-c9vu8ako	384	2	observed	observe	VBD
cord-007444-c9vu8ako	384	3	episodes	episode	NNS
cord-007444-c9vu8ako	384	4	of	of	IN
cord-007444-c9vu8ako	384	5	acute	acute	JJ
cord-007444-c9vu8ako	384	6	respiratory	respiratory	JJ
cord-007444-c9vu8ako	384	7	failure	failure	NN
cord-007444-c9vu8ako	384	8	in	in	IN
cord-007444-c9vu8ako	384	9	19	19	CD
cord-007444-c9vu8ako	384	10	and	and	CC
cord-007444-c9vu8ako	384	11	33	33	CD
cord-007444-c9vu8ako	384	12	patients	patient	NNS
cord-007444-c9vu8ako	384	13	with	with	IN
cord-007444-c9vu8ako	384	14	baseline	baseline	JJ
cord-007444-c9vu8ako	384	15	FEV	FEV	NNP
cord-007444-c9vu8ako	384	16	,	,	,
cord-007444-c9vu8ako	384	17	of	of	IN
cord-007444-c9vu8ako	384	18	greater	great	JJR
cord-007444-c9vu8ako	384	19	and	and	CC
cord-007444-c9vu8ako	384	20	less	less	JJR
cord-007444-c9vu8ako	384	21	than	than	IN
cord-007444-c9vu8ako	384	22	1	1	CD
cord-007444-c9vu8ako	384	23	L	l	NN
cord-007444-c9vu8ako	384	24	respectively	respectively	RB
cord-007444-c9vu8ako	384	25	.	.	.
cord-007444-c9vu8ako	385	1	Only	only	RB
cord-007444-c9vu8ako	385	2	56	56	CD
cord-007444-c9vu8ako	385	3	%	%	NN
cord-007444-c9vu8ako	385	4	of	of	IN
cord-007444-c9vu8ako	385	5	the	the	DT
cord-007444-c9vu8ako	385	6	cohort	cohort	NN
cord-007444-c9vu8ako	385	7	with	with	IN
cord-007444-c9vu8ako	385	8	severe	severe	JJ
cord-007444-c9vu8ako	385	9	COPD	COPD	NNP
cord-007444-c9vu8ako	385	10	survived	survive	VBD
cord-007444-c9vu8ako	385	11	weaning	wean	VBG
cord-007444-c9vu8ako	385	12	and	and	CC
cord-007444-c9vu8ako	385	13	spontaneous	spontaneous	JJ
cord-007444-c9vu8ako	385	14	breathing	breathing	NN
cord-007444-c9vu8ako	385	15	for	for	IN
cord-007444-c9vu8ako	385	16	72	72	CD
cord-007444-c9vu8ako	385	17	hours	hour	NNS
cord-007444-c9vu8ako	385	18	.	.	.
cord-007444-c9vu8ako	386	1	Furthermore	furthermore	RB
cord-007444-c9vu8ako	386	2	,	,	,
cord-007444-c9vu8ako	386	3	in	in	IN
cord-007444-c9vu8ako	386	4	the	the	DT
cord-007444-c9vu8ako	386	5	same	same	JJ
cord-007444-c9vu8ako	386	6	group	group	NN
cord-007444-c9vu8ako	386	7	,	,	,
cord-007444-c9vu8ako	386	8	1-year	1-year	CD
cord-007444-c9vu8ako	386	9	survival	survival	NN
cord-007444-c9vu8ako	386	10	was	be	VBD
cord-007444-c9vu8ako	386	11	only	only	RB
cord-007444-c9vu8ako	386	12	27	27	CD
cord-007444-c9vu8ako	386	13	%	%	NN
cord-007444-c9vu8ako	386	14	.	.	.
cord-007444-c9vu8ako	387	1	Absence	absence	NN
cord-007444-c9vu8ako	387	2	of	of	IN
cord-007444-c9vu8ako	387	3	infiltrates	infiltrate	NNS
cord-007444-c9vu8ako	387	4	on	on	IN
cord-007444-c9vu8ako	387	5	chest	chest	NN
cord-007444-c9vu8ako	387	6	radiograph	radiograph	NN
cord-007444-c9vu8ako	387	7	was	be	VBD
cord-007444-c9vu8ako	387	8	the	the	DT
cord-007444-c9vu8ako	387	9	most	most	RBS
cord-007444-c9vu8ako	387	10	influential	influential	JJ
cord-007444-c9vu8ako	387	11	predictor	predictor	NN
cord-007444-c9vu8ako	387	12	of	of	IN
cord-007444-c9vu8ako	387	13	survival	survival	NN
cord-007444-c9vu8ako	387	14	in	in	IN
cord-007444-c9vu8ako	387	15	patients	patient	NNS
cord-007444-c9vu8ako	387	16	with	with	IN
cord-007444-c9vu8ako	387	17	severe	severe	JJ
cord-007444-c9vu8ako	387	18	COPD	COPD	NNP
cord-007444-c9vu8ako	387	19	.	.	.
cord-007444-c9vu8ako	388	1	Pneumonia	pneumonia	NN
cord-007444-c9vu8ako	388	2	accounted	account	VBD
cord-007444-c9vu8ako	388	3	for	for	IN
cord-007444-c9vu8ako	388	4	most	most	JJS
cord-007444-c9vu8ako	388	5	of	of	IN
cord-007444-c9vu8ako	388	6	the	the	DT
cord-007444-c9vu8ako	388	7	infiltrates	infiltrate	NNS
cord-007444-c9vu8ako	388	8	that	that	WDT
cord-007444-c9vu8ako	388	9	were	be	VBD
cord-007444-c9vu8ako	388	10	seen	see	VBN
cord-007444-c9vu8ako	388	11	in	in	IN
cord-007444-c9vu8ako	388	12	this	this	DT
cord-007444-c9vu8ako	388	13	group	group	NN
cord-007444-c9vu8ako	388	14	.	.	.
cord-007444-c9vu8ako	389	1	Baseline	Baseline	NNP
cord-007444-c9vu8ako	389	2	FEV	FEV	NNP
cord-007444-c9vu8ako	389	3	,	,	,
cord-007444-c9vu8ako	389	4	obtained	obtain	VBN
cord-007444-c9vu8ako	389	5	during	during	IN
cord-007444-c9vu8ako	389	6	a	a	DT
cord-007444-c9vu8ako	389	7	period	period	NN
cord-007444-c9vu8ako	389	8	of	of	IN
cord-007444-c9vu8ako	389	9	clinical	clinical	JJ
cord-007444-c9vu8ako	389	10	stability	stability	NN
cord-007444-c9vu8ako	389	11	prior	prior	RB
cord-007444-c9vu8ako	389	12	to	to	IN
cord-007444-c9vu8ako	389	13	the	the	DT
cord-007444-c9vu8ako	389	14	episode	episode	NN
cord-007444-c9vu8ako	389	15	of	of	IN
cord-007444-c9vu8ako	389	16	acute	acute	JJ
cord-007444-c9vu8ako	389	17	respiratory	respiratory	JJ
cord-007444-c9vu8ako	389	18	failure	failure	NN
cord-007444-c9vu8ako	389	19	was	be	VBD
cord-007444-c9vu8ako	389	20	available	available	JJ
cord-007444-c9vu8ako	389	21	for	for	IN
cord-007444-c9vu8ako	389	22	all	all	DT
cord-007444-c9vu8ako	389	23	patients	patient	NNS
cord-007444-c9vu8ako	389	24	.	.	.
cord-007444-c9vu8ako	390	1	The	the	DT
cord-007444-c9vu8ako	390	2	extent	extent	NN
cord-007444-c9vu8ako	390	3	of	of	IN
cord-007444-c9vu8ako	390	4	baseline	baseline	JJ
cord-007444-c9vu8ako	390	5	obstruction	obstruction	NN
cord-007444-c9vu8ako	390	6	alone	alone	RB
cord-007444-c9vu8ako	390	7	was	be	VBD
cord-007444-c9vu8ako	390	8	not	not	RB
cord-007444-c9vu8ako	390	9	statistically	statistically	RB
cord-007444-c9vu8ako	390	10	correlated	correlate	VBN
cord-007444-c9vu8ako	390	11	with	with	IN
cord-007444-c9vu8ako	390	12	short	short	JJ
cord-007444-c9vu8ako	390	13	-	-	HYPH
cord-007444-c9vu8ako	390	14	term	term	NN
cord-007444-c9vu8ako	390	15	survival	survival	NN
cord-007444-c9vu8ako	390	16	in	in	IN
cord-007444-c9vu8ako	390	17	either	either	DT
cord-007444-c9vu8ako	390	18	group	group	NN
cord-007444-c9vu8ako	390	19	,	,	,
cord-007444-c9vu8ako	390	20	but	but	CC
cord-007444-c9vu8ako	390	21	the	the	DT
cord-007444-c9vu8ako	390	22	combination	combination	NN
cord-007444-c9vu8ako	390	23	of	of	IN
cord-007444-c9vu8ako	390	24	severe	severe	JJ
cord-007444-c9vu8ako	390	25	baseline	baseline	JJ
cord-007444-c9vu8ako	390	26	obstruction	obstruction	NN
cord-007444-c9vu8ako	390	27	and	and	CC
cord-007444-c9vu8ako	390	28	pulmonary	pulmonary	NN
cord-007444-c9vu8ako	390	29	infiltrates	infiltrate	VBZ
cord-007444-c9vu8ako	390	30	markedly	markedly	RB
cord-007444-c9vu8ako	390	31	increased	increase	VBD
cord-007444-c9vu8ako	390	32	the	the	DT
cord-007444-c9vu8ako	390	33	risk	risk	NN
cord-007444-c9vu8ako	390	34	for	for	IN
cord-007444-c9vu8ako	390	35	death	death	NN
cord-007444-c9vu8ako	390	36	.	.	.
cord-007444-c9vu8ako	391	1	Outcomes	outcome	NNS
cord-007444-c9vu8ako	391	2	following	follow	VBG
cord-007444-c9vu8ako	391	3	AECOPD	AECOPD	NNP
cord-007444-c9vu8ako	391	4	associated	associate	VBN
cord-007444-c9vu8ako	391	5	with	with	IN
cord-007444-c9vu8ako	391	6	ICU	ICU	NNP
cord-007444-c9vu8ako	391	7	admission	admission	NN
cord-007444-c9vu8ako	391	8	and	and	CC
cord-007444-c9vu8ako	391	9	respiratory	respiratory	JJ
cord-007444-c9vu8ako	391	10	failure	failure	NN
cord-007444-c9vu8ako	391	11	are	be	VBP
cord-007444-c9vu8ako	391	12	A	a	DT
cord-007444-c9vu8ako	391	13	study	study	NN
cord-007444-c9vu8ako	391	14	by	by	IN
cord-007444-c9vu8ako	391	15	Dewan	Dewan	NNP
cord-007444-c9vu8ako	391	16	and	and	CC
cord-007444-c9vu8ako	391	17	discussed	discuss	VBN
cord-007444-c9vu8ako	391	18	further	further	RB
cord-007444-c9vu8ako	391	19	in	in	IN
cord-007444-c9vu8ako	391	20	the	the	DT
cord-007444-c9vu8ako	391	21	article	article	NN
cord-007444-c9vu8ako	391	22	by	by	IN
cord-007444-c9vu8ako	391	23	Sethi	Sethi	NNP
cord-007444-c9vu8ako	391	24	and	and	CC
cord-007444-c9vu8ako	391	25	Siege1	Siege1	NNP
cord-007444-c9vu8ako	391	26	in	in	IN
cord-007444-c9vu8ako	391	27	this	this	DT
cord-007444-c9vu8ako	391	28	issue	issue	NN
cord-007444-c9vu8ako	391	29	.	.	.
cord-007444-c9vu8ako	392	1	Seneff	Seneff	NNP
cord-007444-c9vu8ako	392	2	et	et	IN
cord-007444-c9vu8ako	392	3	allo7	allo7	NN
cord-007444-c9vu8ako	392	4	recently	recently	RB
cord-007444-c9vu8ako	392	5	refined	refine	VBD
cord-007444-c9vu8ako	392	6	the	the	DT
cord-007444-c9vu8ako	392	7	discussion	discussion	NN
cord-007444-c9vu8ako	392	8	over	over	IN
cord-007444-c9vu8ako	392	9	the	the	DT
cord-007444-c9vu8ako	392	10	relative	relative	JJ
cord-007444-c9vu8ako	392	11	prognostic	prognostic	JJ
cord-007444-c9vu8ako	392	12	value	value	NN
cord-007444-c9vu8ako	392	13	of	of	IN
cord-007444-c9vu8ako	392	14	different	different	JJ
cord-007444-c9vu8ako	392	15	clinical	clinical	JJ
cord-007444-c9vu8ako	392	16	variables	variable	NNS
cord-007444-c9vu8ako	392	17	following	follow	VBG
cord-007444-c9vu8ako	392	18	COPD	COPD	NNP
cord-007444-c9vu8ako	392	19	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	392	20	.	.	.
cord-007444-c9vu8ako	393	1	They	-PRON-	PRP
cord-007444-c9vu8ako	393	2	analyzed	analyze	VBD
cord-007444-c9vu8ako	393	3	362	362	CD
cord-007444-c9vu8ako	393	4	admissions	admission	NNS
cord-007444-c9vu8ako	393	5	for	for	IN
cord-007444-c9vu8ako	393	6	acute	acute	JJ
cord-007444-c9vu8ako	393	7	COPD	COPD	NNP
cord-007444-c9vu8ako	393	8	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	393	9	from	from	IN
cord-007444-c9vu8ako	393	10	the	the	DT
cord-007444-c9vu8ako	393	11	APACHE	APACHE	NNP
cord-007444-c9vu8ako	393	12	I11	I11	NNP
cord-007444-c9vu8ako	393	13	database	database	NN
cord-007444-c9vu8ako	393	14	.	.	.
cord-007444-c9vu8ako	394	1	Hospital	hospital	NN
cord-007444-c9vu8ako	394	2	mortality	mortality	NN
cord-007444-c9vu8ako	394	3	was	be	VBD
cord-007444-c9vu8ako	394	4	24	24	CD
cord-007444-c9vu8ako	394	5	%	%	NN
cord-007444-c9vu8ako	394	6	.	.	.
cord-007444-c9vu8ako	395	1	For	for	IN
cord-007444-c9vu8ako	395	2	patients	patient	NNS
cord-007444-c9vu8ako	395	3	aged	age	VBN
cord-007444-c9vu8ako	395	4	65	65	CD
cord-007444-c9vu8ako	395	5	and	and	CC
cord-007444-c9vu8ako	395	6	older	old	JJR
cord-007444-c9vu8ako	395	7	,	,	,
cord-007444-c9vu8ako	395	8	hospital	hospital	NN
cord-007444-c9vu8ako	395	9	and	and	CC
cord-007444-c9vu8ako	395	10	1-year	1-year	CD
cord-007444-c9vu8ako	395	11	mortality	mortality	NN
cord-007444-c9vu8ako	395	12	rates	rate	NNS
cord-007444-c9vu8ako	395	13	were	be	VBD
cord-007444-c9vu8ako	395	14	30	30	CD
cord-007444-c9vu8ako	395	15	%	%	NN
cord-007444-c9vu8ako	395	16	and	and	CC
cord-007444-c9vu8ako	395	17	59	59	CD
cord-007444-c9vu8ako	395	18	%	%	NN
cord-007444-c9vu8ako	395	19	respectively	respectively	RB
cord-007444-c9vu8ako	395	20	.	.	.
cord-007444-c9vu8ako	396	1	Their	-PRON-	PRP$
cord-007444-c9vu8ako	396	2	report	report	NN
cord-007444-c9vu8ako	396	3	emphasizes	emphasize	VBZ
cord-007444-c9vu8ako	396	4	that	that	IN
cord-007444-c9vu8ako	396	5	individual	individual	JJ
cord-007444-c9vu8ako	396	6	clinical	clinical	JJ
cord-007444-c9vu8ako	396	7	variables	variable	NNS
cord-007444-c9vu8ako	396	8	have	have	VBP
cord-007444-c9vu8ako	396	9	different	different	JJ
cord-007444-c9vu8ako	396	10	value	value	NN
cord-007444-c9vu8ako	396	11	for	for	IN
cord-007444-c9vu8ako	396	12	predicting	predict	VBG
cord-007444-c9vu8ako	396	13	short	short	JJ
cord-007444-c9vu8ako	396	14	-	-	HYPH
cord-007444-c9vu8ako	396	15	and	and	CC
cord-007444-c9vu8ako	396	16	long	long	JJ
cord-007444-c9vu8ako	396	17	-	-	HYPH
cord-007444-c9vu8ako	396	18	term	term	NN
cord-007444-c9vu8ako	396	19	survival	survival	NN
cord-007444-c9vu8ako	396	20	.	.	.
cord-007444-c9vu8ako	397	1	Patient	patient	JJ
cord-007444-c9vu8ako	397	2	age	age	NN
cord-007444-c9vu8ako	397	3	,	,	,
cord-007444-c9vu8ako	397	4	for	for	IN
cord-007444-c9vu8ako	397	5	example	example	NN
cord-007444-c9vu8ako	397	6	,	,	,
cord-007444-c9vu8ako	397	7	was	be	VBD
cord-007444-c9vu8ako	397	8	a	a	DT
cord-007444-c9vu8ako	397	9	statistically	statistically	RB
cord-007444-c9vu8ako	397	10	significant	significant	JJ
cord-007444-c9vu8ako	397	11	determinant	determinant	NN
cord-007444-c9vu8ako	397	12	of	of	IN
cord-007444-c9vu8ako	397	13	6-month	6-month	CD
cord-007444-c9vu8ako	397	14	survival	survival	NN
cord-007444-c9vu8ako	397	15	but	but	CC
cord-007444-c9vu8ako	397	16	not	not	RB
cord-007444-c9vu8ako	397	17	influential	influential	JJ
cord-007444-c9vu8ako	397	18	for	for	IN
cord-007444-c9vu8ako	397	19	hospital	hospital	NN
cord-007444-c9vu8ako	397	20	mortality	mortality	NN
cord-007444-c9vu8ako	397	21	after	after	IN
cord-007444-c9vu8ako	397	22	accounting	account	VBG
cord-007444-c9vu8ako	397	23	for	for	IN
cord-007444-c9vu8ako	397	24	nonrespiratory	nonrespiratory	NNP
cord-007444-c9vu8ako	397	25	organ	organ	NNP
cord-007444-c9vu8ako	397	26	dysfunction	dysfunction	NN
cord-007444-c9vu8ako	397	27	.	.	.
cord-007444-c9vu8ako	398	1	Similarly	similarly	RB
cord-007444-c9vu8ako	398	2	,	,	,
cord-007444-c9vu8ako	398	3	the	the	DT
cord-007444-c9vu8ako	398	4	presence	presence	NN
cord-007444-c9vu8ako	398	5	of	of	IN
cord-007444-c9vu8ako	398	6	hypercarbia	hypercarbia	NNP
cord-007444-c9vu8ako	398	7	was	be	VBD
cord-007444-c9vu8ako	398	8	of	of	IN
cord-007444-c9vu8ako	398	9	no	no	DT
cord-007444-c9vu8ako	398	10	value	value	NN
cord-007444-c9vu8ako	398	11	in	in	IN
cord-007444-c9vu8ako	398	12	predicting	predict	VBG
cord-007444-c9vu8ako	398	13	hospital	hospital	NN
cord-007444-c9vu8ako	398	14	mortality	mortality	NN
cord-007444-c9vu8ako	398	15	but	but	CC
cord-007444-c9vu8ako	398	16	became	become	VBD
cord-007444-c9vu8ako	398	17	important	important	JJ
cord-007444-c9vu8ako	398	18	over	over	IN
cord-007444-c9vu8ako	398	19	the	the	DT
cord-007444-c9vu8ako	398	20	long	long	JJ
cord-007444-c9vu8ako	398	21	term	term	NN
cord-007444-c9vu8ako	398	22	;	;	:
cord-007444-c9vu8ako	398	23	1-year	1-year	CD
cord-007444-c9vu8ako	398	24	mortality	mortality	NN
cord-007444-c9vu8ako	398	25	rates	rate	NNS
cord-007444-c9vu8ako	398	26	for	for	IN
cord-007444-c9vu8ako	398	27	patients	patient	NNS
cord-007444-c9vu8ako	398	28	with	with	IN
cord-007444-c9vu8ako	398	29	admission	admission	NN
cord-007444-c9vu8ako	398	30	Paco2	paco2	JJ
cord-007444-c9vu8ako	398	31	of	of	IN
cord-007444-c9vu8ako	398	32	less	less	JJR
cord-007444-c9vu8ako	398	33	than	than	IN
cord-007444-c9vu8ako	398	34	50	50	CD
cord-007444-c9vu8ako	398	35	mm	mm	NN
cord-007444-c9vu8ako	398	36	Hg	hg	NN
cord-007444-c9vu8ako	398	37	versus	versus	IN
cord-007444-c9vu8ako	398	38	greater	great	JJR
cord-007444-c9vu8ako	398	39	than	than	IN
cord-007444-c9vu8ako	398	40	50	50	CD
cord-007444-c9vu8ako	398	41	mm	mm	NNS
cord-007444-c9vu8ako	399	1	Hg	Hg	NNS
cord-007444-c9vu8ako	399	2	were	be	VBD
cord-007444-c9vu8ako	399	3	54	54	CD
cord-007444-c9vu8ako	399	4	%	%	NN
cord-007444-c9vu8ako	399	5	and	and	CC
cord-007444-c9vu8ako	399	6	70	70	CD
cord-007444-c9vu8ako	399	7	%	%	NN
cord-007444-c9vu8ako	399	8	respectively	respectively	RB
cord-007444-c9vu8ako	399	9	.	.	.
cord-007444-c9vu8ako	400	1	The	the	DT
cord-007444-c9vu8ako	400	2	most	most	RBS
cord-007444-c9vu8ako	400	3	significant	significant	JJ
cord-007444-c9vu8ako	400	4	predictors	predictor	NNS
cord-007444-c9vu8ako	400	5	of	of	IN
cord-007444-c9vu8ako	400	6	short	short	JJ
cord-007444-c9vu8ako	400	7	and	and	CC
cord-007444-c9vu8ako	400	8	long	long	JJ
cord-007444-c9vu8ako	400	9	-	-	HYPH
cord-007444-c9vu8ako	400	10	term	term	NN
cord-007444-c9vu8ako	400	11	mortality	mortality	NN
cord-007444-c9vu8ako	400	12	are	be	VBP
cord-007444-c9vu8ako	400	13	development	development	NN
cord-007444-c9vu8ako	400	14	and	and	CC
cord-007444-c9vu8ako	400	15	severity	severity	NN
cord-007444-c9vu8ako	400	16	of	of	IN
cord-007444-c9vu8ako	400	17	multiple	multiple	JJ
cord-007444-c9vu8ako	400	18	organ	organ	NN
cord-007444-c9vu8ako	400	19	dysfunction	dysfunction	NN
cord-007444-c9vu8ako	400	20	syndrome	syndrome	NN
cord-007444-c9vu8ako	400	21	.	.	.
cord-007444-c9vu8ako	401	1	Respiratory	respiratory	JJ
cord-007444-c9vu8ako	401	2	dysfunction	dysfunction	NN
cord-007444-c9vu8ako	401	3	is	be	VBZ
cord-007444-c9vu8ako	401	4	more	more	RBR
cord-007444-c9vu8ako	401	5	important	important	JJ
cord-007444-c9vu8ako	401	6	over	over	IN
cord-007444-c9vu8ako	401	7	the	the	DT
cord-007444-c9vu8ako	401	8	longer	long	JJR
cord-007444-c9vu8ako	401	9	term	term	NN
cord-007444-c9vu8ako	401	10	.	.	.
cord-007444-c9vu8ako	402	1	As	as	IN
cord-007444-c9vu8ako	402	2	the	the	DT
cord-007444-c9vu8ako	402	3	authors	author	NNS
cord-007444-c9vu8ako	402	4	state	state	NN
cord-007444-c9vu8ako	402	5	:	:	:
cord-007444-c9vu8ako	402	6	"	"	``
cord-007444-c9vu8ako	402	7	In	in	IN
cord-007444-c9vu8ako	402	8	most	most	JJS
cord-007444-c9vu8ako	402	9	cases	case	NNS
cord-007444-c9vu8ako	402	10	,	,	,
cord-007444-c9vu8ako	402	11	the	the	DT
cord-007444-c9vu8ako	402	12	acute	acute	JJ
cord-007444-c9vu8ako	402	13	,	,	,
cord-007444-c9vu8ako	402	14	life	life	NN
cord-007444-c9vu8ako	402	15	-	-	HYPH
cord-007444-c9vu8ako	402	16	threatening	threaten	VBG
cord-007444-c9vu8ako	402	17	components	component	NNS
cord-007444-c9vu8ako	402	18	of	of	IN
cord-007444-c9vu8ako	402	19	the	the	DT
cord-007444-c9vu8ako	402	20	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	402	21	can	can	MD
cord-007444-c9vu8ako	402	22	be	be	VB
cord-007444-c9vu8ako	402	23	reversed	reverse	VBN
cord-007444-c9vu8ako	402	24	and	and	CC
cord-007444-c9vu8ako	402	25	short	short	JJ
cord-007444-c9vu8ako	402	26	-	-	HYPH
cord-007444-c9vu8ako	402	27	term	term	NN
cord-007444-c9vu8ako	402	28	death	death	NN
cord-007444-c9vu8ako	402	29	avoided	avoid	VBN
cord-007444-c9vu8ako	402	30	by	by	IN
cord-007444-c9vu8ako	402	31	mechanical	mechanical	JJ
cord-007444-c9vu8ako	402	32	ventilation	ventilation	NN
cord-007444-c9vu8ako	402	33	and	and	CC
cord-007444-c9vu8ako	402	34	other	other	JJ
cord-007444-c9vu8ako	402	35	appropriate	appropriate	JJ
cord-007444-c9vu8ako	402	36	treatments	treatment	NNS
cord-007444-c9vu8ako	402	37	.	.	.
cord-007444-c9vu8ako	403	1	However	however	RB
cord-007444-c9vu8ako	403	2	,	,	,
cord-007444-c9vu8ako	403	3	because	because	IN
cord-007444-c9vu8ako	403	4	abnormalities	abnormality	NNS
cord-007444-c9vu8ako	403	5	in	in	IN
cord-007444-c9vu8ako	403	6	respiratory	respiratory	JJ
cord-007444-c9vu8ako	403	7	physiology	physiology	NN
cord-007444-c9vu8ako	403	8	reflect	reflect	VBP
cord-007444-c9vu8ako	403	9	underlying	underlie	VBG
cord-007444-c9vu8ako	403	10	severity	severity	NN
cord-007444-c9vu8ako	403	11	of	of	IN
cord-007444-c9vu8ako	403	12	lung	lung	NN
cord-007444-c9vu8ako	403	13	disease	disease	NN
cord-007444-c9vu8ako	403	14	,	,	,
cord-007444-c9vu8ako	403	15	patients	patient	NNS
cord-007444-c9vu8ako	403	16	with	with	IN
cord-007444-c9vu8ako	403	17	greater	great	JJR
cord-007444-c9vu8ako	403	18	abnormality	abnormality	NN
cord-007444-c9vu8ako	403	19	who	who	WP
cord-007444-c9vu8ako	403	20	survive	survive	VBP
cord-007444-c9vu8ako	403	21	hospitalization	hospitalization	NN
cord-007444-c9vu8ako	403	22	are	be	VBP
cord-007444-c9vu8ako	403	23	at	at	IN
cord-007444-c9vu8ako	403	24	greater	great	JJR
cord-007444-c9vu8ako	403	25	risk	risk	NN
cord-007444-c9vu8ako	403	26	of	of	IN
cord-007444-c9vu8ako	403	27	subsequent	subsequent	JJ
cord-007444-c9vu8ako	403	28	death	death	NN
cord-007444-c9vu8ako	403	29	.	.	.
cord-007444-c9vu8ako	404	1	"	"	``
cord-007444-c9vu8ako	404	2	Io7	Io7	NNP
cord-007444-c9vu8ako	405	1	Chronic	chronic	JJ
cord-007444-c9vu8ako	405	2	obstructive	obstructive	JJ
cord-007444-c9vu8ako	405	3	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	405	4	disease	disease	NN
cord-007444-c9vu8ako	405	5	is	be	VBZ
cord-007444-c9vu8ako	405	6	the	the	DT
cord-007444-c9vu8ako	405	7	only	only	RB
cord-007444-c9vu8ako	405	8	leading	leading	JJ
cord-007444-c9vu8ako	405	9	cause	cause	NN
cord-007444-c9vu8ako	405	10	of	of	IN
cord-007444-c9vu8ako	405	11	death	death	NN
cord-007444-c9vu8ako	405	12	with	with	IN
cord-007444-c9vu8ako	405	13	a	a	DT
cord-007444-c9vu8ako	405	14	rising	rise	VBG
cord-007444-c9vu8ako	405	15	prevalence	prevalence	NN
cord-007444-c9vu8ako	405	16	.	.	.
cord-007444-c9vu8ako	406	1	The	the	DT
cord-007444-c9vu8ako	406	2	medical	medical	JJ
cord-007444-c9vu8ako	406	3	and	and	CC
cord-007444-c9vu8ako	406	4	economic	economic	JJ
cord-007444-c9vu8ako	406	5	costs	cost	NNS
cord-007444-c9vu8ako	406	6	arising	arise	VBG
cord-007444-c9vu8ako	406	7	from	from	IN
cord-007444-c9vu8ako	406	8	acute	acute	JJ
cord-007444-c9vu8ako	406	9	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	406	10	of	of	IN
cord-007444-c9vu8ako	406	11	COPD	COPD	NNP
cord-007444-c9vu8ako	406	12	are	be	VBP
cord-007444-c9vu8ako	406	13	therefore	therefore	RB
cord-007444-c9vu8ako	406	14	expected	expect	VBN
cord-007444-c9vu8ako	406	15	to	to	TO
cord-007444-c9vu8ako	406	16	increase	increase	VB
cord-007444-c9vu8ako	406	17	over	over	IN
cord-007444-c9vu8ako	406	18	the	the	DT
cord-007444-c9vu8ako	406	19	coming	come	VBG
cord-007444-c9vu8ako	406	20	years	year	NNS
cord-007444-c9vu8ako	406	21	.	.	.
cord-007444-c9vu8ako	407	1	Although	although	IN
cord-007444-c9vu8ako	407	2	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	407	3	may	may	MD
cord-007444-c9vu8ako	407	4	be	be	VB
cord-007444-c9vu8ako	407	5	initiated	initiate	VBN
cord-007444-c9vu8ako	407	6	by	by	IN
cord-007444-c9vu8ako	407	7	multiple	multiple	JJ
cord-007444-c9vu8ako	407	8	factors	factor	NNS
cord-007444-c9vu8ako	407	9	,	,	,
cord-007444-c9vu8ako	407	10	the	the	DT
cord-007444-c9vu8ako	407	11	most	most	RBS
cord-007444-c9vu8ako	407	12	common	common	JJ
cord-007444-c9vu8ako	407	13	identifiable	identifiable	JJ
cord-007444-c9vu8ako	407	14	associations	association	NNS
cord-007444-c9vu8ako	407	15	are	be	VBP
cord-007444-c9vu8ako	407	16	with	with	IN
cord-007444-c9vu8ako	407	17	bacterial	bacterial	JJ
cord-007444-c9vu8ako	407	18	and	and	CC
cord-007444-c9vu8ako	407	19	viral	viral	JJ
cord-007444-c9vu8ako	407	20	infections	infection	NNS
cord-007444-c9vu8ako	407	21	.	.	.
cord-007444-c9vu8ako	408	1	These	these	DT
cord-007444-c9vu8ako	408	2	are	be	VBP
cord-007444-c9vu8ako	408	3	associated	associate	VBN
cord-007444-c9vu8ako	408	4	with	with	IN
cord-007444-c9vu8ako	408	5	approximately	approximately	RB
cord-007444-c9vu8ako	408	6	50	50	CD
cord-007444-c9vu8ako	408	7	%	%	NN
cord-007444-c9vu8ako	408	8	to	to	TO
cord-007444-c9vu8ako	408	9	70	70	CD
cord-007444-c9vu8ako	408	10	%	%	NN
cord-007444-c9vu8ako	408	11	and	and	CC
cord-007444-c9vu8ako	408	12	20	20	CD
cord-007444-c9vu8ako	408	13	%	%	NN
cord-007444-c9vu8ako	408	14	to	to	TO
cord-007444-c9vu8ako	408	15	30	30	CD
cord-007444-c9vu8ako	408	16	%	%	NN
cord-007444-c9vu8ako	408	17	of	of	IN
cord-007444-c9vu8ako	408	18	COPD	COPD	NNP
cord-007444-c9vu8ako	408	19	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	408	20	,	,	,
cord-007444-c9vu8ako	408	21	respectively	respectively	RB
cord-007444-c9vu8ako	408	22	.	.	.
cord-007444-c9vu8ako	409	1	In	in	IN
cord-007444-c9vu8ako	409	2	addition	addition	NN
cord-007444-c9vu8ako	409	3	to	to	IN
cord-007444-c9vu8ako	409	4	smoking	smoking	NN
cord-007444-c9vu8ako	409	5	cessation	cessation	NN
cord-007444-c9vu8ako	409	6	,	,	,
cord-007444-c9vu8ako	409	7	annual	annual	JJ
cord-007444-c9vu8ako	409	8	influenza	influenza	NN
cord-007444-c9vu8ako	409	9	vaccination	vaccination	NN
cord-007444-c9vu8ako	409	10	is	be	VBZ
cord-007444-c9vu8ako	409	11	the	the	DT
cord-007444-c9vu8ako	409	12	most	most	RBS
cord-007444-c9vu8ako	409	13	important	important	JJ
cord-007444-c9vu8ako	409	14	method	method	NN
cord-007444-c9vu8ako	409	15	for	for	IN
cord-007444-c9vu8ako	409	16	preventing	prevent	VBG
cord-007444-c9vu8ako	409	17	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	409	18	.	.	.
cord-007444-c9vu8ako	410	1	Controlled	Controlled	NNP
cord-007444-c9vu8ako	410	2	O2	O2	NNP
cord-007444-c9vu8ako	410	3	is	be	VBZ
cord-007444-c9vu8ako	410	4	the	the	DT
cord-007444-c9vu8ako	410	5	most	most	RBS
cord-007444-c9vu8ako	410	6	important	important	JJ
cord-007444-c9vu8ako	410	7	intervention	intervention	NN
cord-007444-c9vu8ako	410	8	for	for	IN
cord-007444-c9vu8ako	410	9	patients	patient	NNS
cord-007444-c9vu8ako	410	10	with	with	IN
cord-007444-c9vu8ako	410	11	acute	acute	JJ
cord-007444-c9vu8ako	410	12	hypoxic	hypoxic	JJ
cord-007444-c9vu8ako	410	13	respiratory	respiratory	JJ
cord-007444-c9vu8ako	410	14	failue	failue	NNS
cord-007444-c9vu8ako	410	15	.	.	.
cord-007444-c9vu8ako	411	1	Evidence	evidence	NN
cord-007444-c9vu8ako	411	2	from	from	IN
cord-007444-c9vu8ako	411	3	randomized	randomized	JJ
cord-007444-c9vu8ako	411	4	,	,	,
cord-007444-c9vu8ako	411	5	controlled	control	VBN
cord-007444-c9vu8ako	411	6	trials	trial	NNS
cord-007444-c9vu8ako	411	7	justifies	justify	VBZ
cord-007444-c9vu8ako	411	8	the	the	DT
cord-007444-c9vu8ako	411	9	use	use	NN
cord-007444-c9vu8ako	411	10	of	of	IN
cord-007444-c9vu8ako	411	11	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	411	12	,	,	,
cord-007444-c9vu8ako	411	13	bronchodilators	bronchodilator	NNS
cord-007444-c9vu8ako	411	14	(	(	-LRB-
cord-007444-c9vu8ako	411	15	but	but	CC
cord-007444-c9vu8ako	411	16	not	not	RB
cord-007444-c9vu8ako	411	17	theophylline	theophylline	JJ
cord-007444-c9vu8ako	411	18	)	)	-RRB-
cord-007444-c9vu8ako	411	19	,	,	,
cord-007444-c9vu8ako	411	20	noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	411	21	positive	positive	JJ
cord-007444-c9vu8ako	411	22	-	-	HYPH
cord-007444-c9vu8ako	411	23	pressure	pressure	NN
cord-007444-c9vu8ako	411	24	ventilation	ventilation	NN
cord-007444-c9vu8ako	411	25	(	(	-LRB-
cord-007444-c9vu8ako	411	26	in	in	IN
cord-007444-c9vu8ako	411	27	selected	select	VBN
cord-007444-c9vu8ako	411	28	patients	patient	NNS
cord-007444-c9vu8ako	411	29	)	)	-RRB-
cord-007444-c9vu8ako	411	30	,	,	,
cord-007444-c9vu8ako	411	31	and	and	CC
cord-007444-c9vu8ako	411	32	antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	411	33	,	,	,
cord-007444-c9vu8ako	411	34	particularly	particularly	RB
cord-007444-c9vu8ako	411	35	for	for	IN
cord-007444-c9vu8ako	411	36	severe	severe	JJ
cord-007444-c9vu8ako	411	37	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	411	38	.	.	.
cord-007444-c9vu8ako	412	1	Antibiotics	antibiotic	NNS
cord-007444-c9vu8ako	412	2	should	should	MD
cord-007444-c9vu8ako	412	3	be	be	VB
cord-007444-c9vu8ako	412	4	chosen	choose	VBN
cord-007444-c9vu8ako	412	5	according	accord	VBG
cord-007444-c9vu8ako	412	6	to	to	IN
cord-007444-c9vu8ako	412	7	the	the	DT
cord-007444-c9vu8ako	412	8	patient	patient	NN
cord-007444-c9vu8ako	412	9	's	's	POS
cord-007444-c9vu8ako	412	10	risk	risk	NN
cord-007444-c9vu8ako	412	11	for	for	IN
cord-007444-c9vu8ako	412	12	treatment	treatment	NN
cord-007444-c9vu8ako	412	13	failure	failure	NN
cord-007444-c9vu8ako	412	14	and	and	CC
cord-007444-c9vu8ako	412	15	the	the	DT
cord-007444-c9vu8ako	412	16	potential	potential	NN
cord-007444-c9vu8ako	412	17	for	for	IN
cord-007444-c9vu8ako	412	18	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	412	19	resistance	resistance	NN
cord-007444-c9vu8ako	412	20	.	.	.
cord-007444-c9vu8ako	413	1	In	in	IN
cord-007444-c9vu8ako	413	2	the	the	DT
cord-007444-c9vu8ako	413	3	acute	acute	JJ
cord-007444-c9vu8ako	413	4	setting	setting	NN
cord-007444-c9vu8ako	413	5	,	,	,
cord-007444-c9vu8ako	413	6	combined	combine	VBN
cord-007444-c9vu8ako	413	7	treatment	treatment	NN
cord-007444-c9vu8ako	413	8	with	with	IN
cord-007444-c9vu8ako	413	9	P	p	NN
cord-007444-c9vu8ako	413	10	-	-	HYPH
cord-007444-c9vu8ako	413	11	agonist	agonist	NN
cord-007444-c9vu8ako	413	12	and	and	CC
cord-007444-c9vu8ako	413	13	anticholinergic	anticholinergic	JJ
cord-007444-c9vu8ako	413	14	bronchodilators	bronchodilator	NNS
cord-007444-c9vu8ako	413	15	is	be	VBZ
cord-007444-c9vu8ako	413	16	reasonable	reasonable	JJ
cord-007444-c9vu8ako	413	17	but	but	CC
cord-007444-c9vu8ako	413	18	not	not	RB
cord-007444-c9vu8ako	413	19	supported	support	VBN
cord-007444-c9vu8ako	413	20	by	by	IN
cord-007444-c9vu8ako	413	21	randomized	randomized	JJ
cord-007444-c9vu8ako	413	22	controlled	control	VBN
cord-007444-c9vu8ako	413	23	studies	study	NNS
cord-007444-c9vu8ako	413	24	.	.	.
cord-007444-c9vu8ako	414	1	Physicians	physician	NNS
cord-007444-c9vu8ako	414	2	should	should	MD
cord-007444-c9vu8ako	414	3	identify	identify	VB
cord-007444-c9vu8ako	414	4	and	and	CC
cord-007444-c9vu8ako	414	5	,	,	,
cord-007444-c9vu8ako	414	6	when	when	WRB
cord-007444-c9vu8ako	414	7	possible	possible	JJ
cord-007444-c9vu8ako	414	8	,	,	,
cord-007444-c9vu8ako	414	9	correct	correct	JJ
cord-007444-c9vu8ako	414	10	malnutrition	malnutrition	NN
cord-007444-c9vu8ako	414	11	.	.	.
cord-007444-c9vu8ako	415	1	Chest	chest	NN
cord-007444-c9vu8ako	415	2	physiotherapy	physiotherapy	NN
cord-007444-c9vu8ako	415	3	has	have	VBZ
cord-007444-c9vu8ako	415	4	no	no	DT
cord-007444-c9vu8ako	415	5	proven	prove	VBN
cord-007444-c9vu8ako	415	6	role	role	NN
cord-007444-c9vu8ako	415	7	in	in	IN
cord-007444-c9vu8ako	415	8	the	the	DT
cord-007444-c9vu8ako	415	9	management	management	NN
cord-007444-c9vu8ako	415	10	of	of	IN
cord-007444-c9vu8ako	415	11	acute	acute	JJ
cord-007444-c9vu8ako	415	12	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	415	13	.	.	.
cord-007444-c9vu8ako	415	14	 	 	_SP
cord-007444-c9vu8ako	416	1	Effect	effect	NN
cord-007444-c9vu8ako	416	2	of	of	IN
cord-007444-c9vu8ako	416	3	non	non	JJ
cord-007444-c9vu8ako	416	4	-	-	JJ
cord-007444-c9vu8ako	416	5	invasive	invasive	JJ
cord-007444-c9vu8ako	416	6	positive	positive	JJ
cord-007444-c9vu8ako	416	7	pressure	pressure	NN
cord-007444-c9vu8ako	416	8	ventilation	ventilation	NN
cord-007444-c9vu8ako	416	9	on	on	IN
cord-007444-c9vu8ako	416	10	mortality	mortality	NN
cord-007444-c9vu8ako	416	11	in	in	IN
cord-007444-c9vu8ako	416	12	patients	patient	NNS
cord-007444-c9vu8ako	416	13	admitted	admit	VBN
cord-007444-c9vu8ako	416	14	with	with	IN
cord-007444-c9vu8ako	416	15	acute	acute	JJ
cord-007444-c9vu8ako	416	16	respiratory	respiratory	JJ
cord-007444-c9vu8ako	416	17	failure	failure	NN
cord-007444-c9vu8ako	416	18	:	:	:
cord-007444-c9vu8ako	416	19	A	a	DT
cord-007444-c9vu8ako	416	20	meta	meta	JJ
cord-007444-c9vu8ako	416	21	-	-	HYPH
cord-007444-c9vu8ako	416	22	analysis	analysis	NN
cord-007444-c9vu8ako	416	23	Clinical	clinical	JJ
cord-007444-c9vu8ako	416	24	efficacy	efficacy	NN
cord-007444-c9vu8ako	416	25	of	of	IN
cord-007444-c9vu8ako	416	26	pneumococcal	pneumococcal	JJ
cord-007444-c9vu8ako	416	27	vaccine	vaccine	NN
cord-007444-c9vu8ako	416	28	in	in	IN
cord-007444-c9vu8ako	416	29	the	the	DT
cord-007444-c9vu8ako	416	30	elderly	elderly	JJ
cord-007444-c9vu8ako	416	31	:	:	:
cord-007444-c9vu8ako	416	32	A	a	DT
cord-007444-c9vu8ako	416	33	randomized	randomized	JJ
cord-007444-c9vu8ako	416	34	,	,	,
cord-007444-c9vu8ako	416	35	single	single	JJ
cord-007444-c9vu8ako	416	36	-	-	HYPH
cord-007444-c9vu8ako	416	37	blind	blind	JJ
cord-007444-c9vu8ako	416	38	population	population	NN
cord-007444-c9vu8ako	416	39	-	-	HYPH
cord-007444-c9vu8ako	416	40	based	base	VBN
cord-007444-c9vu8ako	416	41	trial	trial	NN
cord-007444-c9vu8ako	416	42	Randomized	randomized	JJ
cord-007444-c9vu8ako	416	43	,	,	,
cord-007444-c9vu8ako	416	44	prospective	prospective	JJ
cord-007444-c9vu8ako	416	45	trial	trial	NN
cord-007444-c9vu8ako	416	46	of	of	IN
cord-007444-c9vu8ako	416	47	noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	416	48	positive	positive	JJ
cord-007444-c9vu8ako	416	49	-	-	HYPH
cord-007444-c9vu8ako	416	50	pressure	pressure	NN
cord-007444-c9vu8ako	416	51	ventilation	ventilation	NN
cord-007444-c9vu8ako	416	52	in	in	IN
cord-007444-c9vu8ako	416	53	acute	acute	JJ
cord-007444-c9vu8ako	416	54	respiratory	respiratory	JJ
cord-007444-c9vu8ako	416	55	failure	failure	NN
cord-007444-c9vu8ako	416	56	Does	do	VBZ
cord-007444-c9vu8ako	416	57	chest	chest	NN
cord-007444-c9vu8ako	416	58	physical	physical	JJ
cord-007444-c9vu8ako	416	59	therapy	therapy	NN
cord-007444-c9vu8ako	416	60	work	work	NN
cord-007444-c9vu8ako	416	61	?	?	.
cord-007444-c9vu8ako	417	1	Respiratory	respiratory	JJ
cord-007444-c9vu8ako	417	2	viral	viral	JJ
cord-007444-c9vu8ako	417	3	infections	infection	NNS
cord-007444-c9vu8ako	417	4	in	in	IN
cord-007444-c9vu8ako	417	5	hospital	hospital	NN
cord-007444-c9vu8ako	417	6	patients	patient	NNS
cord-007444-c9vu8ako	417	7	with	with	IN
cord-007444-c9vu8ako	417	8	chronic	chronic	JJ
cord-007444-c9vu8ako	417	9	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	417	10	Bronchodilating	Bronchodilating	NNP
cord-007444-c9vu8ako	417	11	effect	effect	NN
cord-007444-c9vu8ako	417	12	and	and	CC
cord-007444-c9vu8ako	417	13	side	side	NN
cord-007444-c9vu8ako	417	14	effects	effect	NNS
cord-007444-c9vu8ako	417	15	of	of	IN
cord-007444-c9vu8ako	417	16	p2	p2	NNP
cord-007444-c9vu8ako	417	17	adrenoreceptor	adrenoreceptor	NN
cord-007444-c9vu8ako	417	18	stimulants	stimulant	NNS
cord-007444-c9vu8ako	417	19	by	by	IN
cord-007444-c9vu8ako	417	20	different	different	JJ
cord-007444-c9vu8ako	417	21	modes	mode	NNS
cord-007444-c9vu8ako	417	22	of	of	IN
cord-007444-c9vu8ako	417	23	administration	administration	NN
cord-007444-c9vu8ako	417	24	Efficacy	Efficacy	NNP
cord-007444-c9vu8ako	417	25	of	of	IN
cord-007444-c9vu8ako	417	26	pneumococcal	pneumococcal	JJ
cord-007444-c9vu8ako	417	27	vaccine	vaccine	NN
cord-007444-c9vu8ako	417	28	in	in	IN
cord-007444-c9vu8ako	417	29	severe	severe	JJ
cord-007444-c9vu8ako	417	30	chronic	chronic	JJ
cord-007444-c9vu8ako	417	31	obstructive	obstructive	JJ
cord-007444-c9vu8ako	417	32	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	417	33	disease	disease	NN
cord-007444-c9vu8ako	417	34	Aminophylline	Aminophylline	NNP
cord-007444-c9vu8ako	417	35	treatment	treatment	NN
cord-007444-c9vu8ako	417	36	in	in	IN
cord-007444-c9vu8ako	417	37	severe	severe	JJ
cord-007444-c9vu8ako	417	38	acute	acute	JJ
cord-007444-c9vu8ako	417	39	asthma	asthma	NN
cord-007444-c9vu8ako	417	40	.	.	.
cord-007444-c9vu8ako	418	1	A	a	DT
cord-007444-c9vu8ako	418	2	meta	meta	JJ
cord-007444-c9vu8ako	418	3	-	-	HYPH
cord-007444-c9vu8ako	418	4	analysis	analysis	NN
cord-007444-c9vu8ako	418	5	A	A	NNP
cord-007444-c9vu8ako	418	6	controlled	control	VBN
cord-007444-c9vu8ako	418	7	trial	trial	NN
cord-007444-c9vu8ako	418	8	of	of	IN
cord-007444-c9vu8ako	418	9	methylprednisolone	methylprednisolone	NN
cord-007444-c9vu8ako	418	10	in	in	IN
cord-007444-c9vu8ako	418	11	the	the	DT
cord-007444-c9vu8ako	418	12	emergency	emergency	NN
cord-007444-c9vu8ako	418	13	treatment	treatment	NN
cord-007444-c9vu8ako	418	14	of	of	IN
cord-007444-c9vu8ako	418	15	acute	acute	JJ
cord-007444-c9vu8ako	418	16	asthma	asthma	NN
cord-007444-c9vu8ako	418	17	Lode	Lode	NNP
cord-007444-c9vu8ako	418	18	H	H	NNP
cord-007444-c9vu8ako	418	19	Respiratory	respiratory	JJ
cord-007444-c9vu8ako	418	20	tract	tract	NN
cord-007444-c9vu8ako	418	21	infections	infection	NNS
cord-007444-c9vu8ako	418	22	:	:	:
cord-007444-c9vu8ako	418	23	When	when	WRB
cord-007444-c9vu8ako	418	24	is	be	VBZ
cord-007444-c9vu8ako	418	25	antibiotic	antibiotic	JJ
cord-007444-c9vu8ako	418	26	therapy	therapy	NN
cord-007444-c9vu8ako	418	27	indicated	indicate	VBN
cord-007444-c9vu8ako	418	28	?	?	.
cord-007444-c9vu8ako	419	1	Chronic	chronic	JJ
cord-007444-c9vu8ako	419	2	obstructive	obstructive	JJ
cord-007444-c9vu8ako	419	3	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	419	4	disease	disease	NN
cord-007444-c9vu8ako	420	1	Acute	acute	JJ
cord-007444-c9vu8ako	420	2	respiratory	respiratory	JJ
cord-007444-c9vu8ako	420	3	failure	failure	NN
cord-007444-c9vu8ako	421	1	Viral	viral	JJ
cord-007444-c9vu8ako	421	2	and	and	CC
cord-007444-c9vu8ako	421	3	Mycoplasma	Mycoplasma	NNP
cord-007444-c9vu8ako	421	4	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	421	5	infections	infection	NNS
cord-007444-c9vu8ako	421	6	in	in	IN
cord-007444-c9vu8ako	421	7	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	421	8	of	of	IN
cord-007444-c9vu8ako	421	9	chronic	chronic	JJ
cord-007444-c9vu8ako	421	10	lung	lung	NN
cord-007444-c9vu8ako	421	11	disease	disease	NN
cord-007444-c9vu8ako	421	12	Noninvasive	noninvasive	JJ
cord-007444-c9vu8ako	421	13	positive	positive	JJ
cord-007444-c9vu8ako	421	14	pressure	pressure	NN
cord-007444-c9vu8ako	421	15	ventilation	ventilation	NN
cord-007444-c9vu8ako	421	16	in	in	IN
cord-007444-c9vu8ako	421	17	acute	acute	JJ
cord-007444-c9vu8ako	421	18	respiratory	respiratory	JJ
cord-007444-c9vu8ako	421	19	failure	failure	NN
cord-007444-c9vu8ako	422	1	Respir	Respir	NNP
cord-007444-c9vu8ako	422	2	Care	Care	NNP
cord-007444-c9vu8ako	422	3	Clin	Clin	NNP
cord-007444-c9vu8ako	422	4	North	North	NNP
cord-007444-c9vu8ako	422	5	Am	Am	NNP
cord-007444-c9vu8ako	422	6	93	93	CD
cord-007444-c9vu8ako	422	7	.	.	.
cord-007444-c9vu8ako	423	1	Prevention	prevention	NN
cord-007444-c9vu8ako	423	2	and	and	CC
cord-007444-c9vu8ako	423	3	control	control	NN
cord-007444-c9vu8ako	423	4	of	of	IN
cord-007444-c9vu8ako	423	5	pneumoccocal	pneumoccocal	JJ
cord-007444-c9vu8ako	423	6	disease	disease	NN
cord-007444-c9vu8ako	423	7	:	:	:
cord-007444-c9vu8ako	423	8	Recommendations	recommendation	NNS
cord-007444-c9vu8ako	423	9	of	of	IN
cord-007444-c9vu8ako	423	10	the	the	DT
cord-007444-c9vu8ako	423	11	Advisory	Advisory	NNP
cord-007444-c9vu8ako	423	12	Committee	Committee	NNP
cord-007444-c9vu8ako	423	13	on	on	IN
cord-007444-c9vu8ako	423	14	Immunization	Immunization	NNP
cord-007444-c9vu8ako	423	15	Practices	Practices	NNPS
cord-007444-c9vu8ako	423	16	(	(	-LRB-
cord-007444-c9vu8ako	423	17	ACIP	ACIP	NNP
cord-007444-c9vu8ako	423	18	)	)	-RRB-
cord-007444-c9vu8ako	424	1	The	the	DT
cord-007444-c9vu8ako	424	2	interaction	interaction	NN
cord-007444-c9vu8ako	424	3	of	of	IN
cord-007444-c9vu8ako	424	4	pneumolysin	pneumolysin	NNP
cord-007444-c9vu8ako	424	5	sufficient	sufficient	JJ
cord-007444-c9vu8ako	424	6	and	and	CC
cord-007444-c9vu8ako	424	7	deficient	deficient	JJ
cord-007444-c9vu8ako	424	8	isogenic	isogenic	JJ
cord-007444-c9vu8ako	424	9	variants	variant	NNS
cord-007444-c9vu8ako	424	10	of	of	IN
cord-007444-c9vu8ako	424	11	Streptococcus	streptococcus	NN
cord-007444-c9vu8ako	424	12	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	424	13	with	with	IN
cord-007444-c9vu8ako	424	14	human	human	JJ
cord-007444-c9vu8ako	424	15	respiratory	respiratory	JJ
cord-007444-c9vu8ako	424	16	mucosa	mucosa	JJ
cord-007444-c9vu8ako	424	17	Effect	effect	NN
cord-007444-c9vu8ako	424	18	of	of	IN
cord-007444-c9vu8ako	424	19	Pseudomonas	Pseudomonas	NNP
cord-007444-c9vu8ako	424	20	aeruginosa	aeruginosa	NN
cord-007444-c9vu8ako	424	21	rhamnolipids	rhamnolipids	NNP
cord-007444-c9vu8ako	424	22	on	on	IN
cord-007444-c9vu8ako	424	23	mucociliary	mucociliary	JJ
cord-007444-c9vu8ako	424	24	transport	transport	NN
cord-007444-c9vu8ako	424	25	and	and	CC
cord-007444-c9vu8ako	424	26	ciliary	ciliary	NN
cord-007444-c9vu8ako	424	27	beating	beat	VBG
cord-007444-c9vu8ako	424	28	Nebulized	Nebulized	NNP
cord-007444-c9vu8ako	424	29	anticholinergic	anticholinergic	JJ
cord-007444-c9vu8ako	424	30	and	and	CC
cord-007444-c9vu8ako	424	31	sympathomimetic	sympathomimetic	JJ
cord-007444-c9vu8ako	424	32	treatment	treatment	NN
cord-007444-c9vu8ako	424	33	of	of	IN
cord-007444-c9vu8ako	424	34	asthma	asthma	NN
cord-007444-c9vu8ako	424	35	and	and	CC
cord-007444-c9vu8ako	424	36	chronic	chronic	JJ
cord-007444-c9vu8ako	424	37	obstructive	obstructive	JJ
cord-007444-c9vu8ako	424	38	airways	airways	NN
cord-007444-c9vu8ako	424	39	disease	disease	NN
cord-007444-c9vu8ako	424	40	in	in	IN
cord-007444-c9vu8ako	424	41	the	the	DT
cord-007444-c9vu8ako	424	42	emergency	emergency	NN
cord-007444-c9vu8ako	424	43	room	room	NN
cord-007444-c9vu8ako	424	44	Antibody	antibody	NN
cord-007444-c9vu8ako	424	45	responses	response	NNS
cord-007444-c9vu8ako	424	46	to	to	IN
cord-007444-c9vu8ako	424	47	bacterial	bacterial	JJ
cord-007444-c9vu8ako	424	48	antigens	antigen	NNS
cord-007444-c9vu8ako	424	49	during	during	IN
cord-007444-c9vu8ako	424	50	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	424	51	of	of	IN
cord-007444-c9vu8ako	424	52	chronic	chronic	JJ
cord-007444-c9vu8ako	424	53	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	425	1	The	the	DT
cord-007444-c9vu8ako	425	2	Veterans	Veterans	NNPS
cord-007444-c9vu8ako	425	3	Administration	Administration	NNP
cord-007444-c9vu8ako	425	4	cooperative	cooperative	JJ
cord-007444-c9vu8ako	425	5	study	study	NN
cord-007444-c9vu8ako	425	6	of	of	IN
cord-007444-c9vu8ako	425	7	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	425	8	function	function	NN
cord-007444-c9vu8ako	425	9	-	-	HYPH
cord-007444-c9vu8ako	425	10	mortality	mortality	NN
cord-007444-c9vu8ako	425	11	in	in	IN
cord-007444-c9vu8ako	425	12	relation	relation	NN
cord-007444-c9vu8ako	425	13	to	to	IN
cord-007444-c9vu8ako	425	14	respiratory	respiratory	JJ
cord-007444-c9vu8ako	425	15	function	function	NN
cord-007444-c9vu8ako	425	16	in	in	IN
cord-007444-c9vu8ako	425	17	chronic	chronic	JJ
cord-007444-c9vu8ako	425	18	obstructive	obstructive	JJ
cord-007444-c9vu8ako	425	19	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	425	20	disease	disease	NN
cord-007444-c9vu8ako	425	21	Aminophylline	Aminophylline	NNP
cord-007444-c9vu8ako	425	22	for	for	IN
cord-007444-c9vu8ako	425	23	acute	acute	JJ
cord-007444-c9vu8ako	425	24	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	425	25	of	of	IN
cord-007444-c9vu8ako	425	26	chronic	chronic	JJ
cord-007444-c9vu8ako	425	27	obstructive	obstructive	JJ
cord-007444-c9vu8ako	425	28	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	425	29	disease	disease	NN
cord-007444-c9vu8ako	425	30	Severe	Severe	NNP
cord-007444-c9vu8ako	425	31	COPD	COPD	NNP
cord-007444-c9vu8ako	425	32	and	and	CC
cord-007444-c9vu8ako	425	33	acute	acute	JJ
cord-007444-c9vu8ako	425	34	respiratory	respiratory	JJ
cord-007444-c9vu8ako	425	35	failure	failure	NN
cord-007444-c9vu8ako	425	36	.	.	.
cord-007444-c9vu8ako	426	1	Correlates	correlate	NNS
cord-007444-c9vu8ako	426	2	for	for	IN
cord-007444-c9vu8ako	426	3	survival	survival	NN
cord-007444-c9vu8ako	426	4	at	at	IN
cord-007444-c9vu8ako	426	5	the	the	DT
cord-007444-c9vu8ako	426	6	time	time	NN
cord-007444-c9vu8ako	426	7	of	of	IN
cord-007444-c9vu8ako	426	8	tracheal	tracheal	JJ
cord-007444-c9vu8ako	426	9	intubation	intubation	NN
cord-007444-c9vu8ako	426	10	Bacterial	bacterial	JJ
cord-007444-c9vu8ako	426	11	adhesion	adhesion	NN
cord-007444-c9vu8ako	426	12	to	to	IN
cord-007444-c9vu8ako	426	13	oropharyngeal	oropharyngeal	JJ
cord-007444-c9vu8ako	426	14	and	and	CC
cord-007444-c9vu8ako	426	15	chronchial	chronchial	JJ
cord-007444-c9vu8ako	426	16	epithelial	epithelial	JJ
cord-007444-c9vu8ako	426	17	cells	cell	NNS
cord-007444-c9vu8ako	426	18	in	in	IN
cord-007444-c9vu8ako	426	19	smokers	smoker	NNS
cord-007444-c9vu8ako	426	20	with	with	IN
cord-007444-c9vu8ako	426	21	chronic	chronic	JJ
cord-007444-c9vu8ako	426	22	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	426	23	and	and	CC
cord-007444-c9vu8ako	426	24	in	in	IN
cord-007444-c9vu8ako	426	25	healthy	healthy	JJ
cord-007444-c9vu8ako	426	26	nonsmokers	nonsmoker	NNS
cord-007444-c9vu8ako	427	1	The	the	DT
cord-007444-c9vu8ako	427	2	long	long	JJ
cord-007444-c9vu8ako	427	3	-	-	HYPH
cord-007444-c9vu8ako	427	4	term	term	NN
cord-007444-c9vu8ako	427	5	efficacy	efficacy	NN
cord-007444-c9vu8ako	427	6	of	of	IN
cord-007444-c9vu8ako	427	7	methylprednisolone	methylprednisolone	NN
cord-007444-c9vu8ako	427	8	in	in	IN
cord-007444-c9vu8ako	427	9	the	the	DT
cord-007444-c9vu8ako	427	10	treatment	treatment	NN
cord-007444-c9vu8ako	427	11	of	of	IN
cord-007444-c9vu8ako	427	12	acute	acute	JJ
cord-007444-c9vu8ako	427	13	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	427	14	of	of	IN
cord-007444-c9vu8ako	427	15	COPD	COPD	NNP
cord-007444-c9vu8ako	427	16	Antibiotics	Antibiotics	NNPS
cord-007444-c9vu8ako	427	17	in	in	IN
cord-007444-c9vu8ako	427	18	chronic	chronic	JJ
cord-007444-c9vu8ako	427	19	obstructive	obstructive	JJ
cord-007444-c9vu8ako	427	20	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	427	21	disease	disease	NN
cord-007444-c9vu8ako	427	22	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	427	23	.	.	.
cord-007444-c9vu8ako	428	1	A	a	DT
cord-007444-c9vu8ako	428	2	meta	meta	JJ
cord-007444-c9vu8ako	428	3	-	-	HYPH
cord-007444-c9vu8ako	428	4	analysis	analysis	NN
cord-007444-c9vu8ako	428	5	Acute	acute	NN
cord-007444-c9vu8ako	428	6	on	on	IN
cord-007444-c9vu8ako	428	7	chronic	chronic	JJ
cord-007444-c9vu8ako	428	8	respiratory	respiratory	JJ
cord-007444-c9vu8ako	428	9	failure	failure	NN
cord-007444-c9vu8ako	428	10	-	-	HYPH
cord-007444-c9vu8ako	428	11	assessment	assessment	NN
cord-007444-c9vu8ako	428	12	and	and	CC
cord-007444-c9vu8ako	428	13	management	management	NN
cord-007444-c9vu8ako	428	14	of	of	IN
cord-007444-c9vu8ako	428	15	patients	patient	NNS
cord-007444-c9vu8ako	428	16	with	with	IN
cord-007444-c9vu8ako	428	17	COPD	COPD	NNP
cord-007444-c9vu8ako	428	18	in	in	IN
cord-007444-c9vu8ako	428	19	the	the	DT
cord-007444-c9vu8ako	428	20	emergent	emergent	JJ
cord-007444-c9vu8ako	428	21	setting	set	VBG
cord-007444-c9vu8ako	428	22	Air	air	NN
cord-007444-c9vu8ako	428	23	pollution	pollution	NN
cord-007444-c9vu8ako	428	24	and	and	CC
cord-007444-c9vu8ako	428	25	hospital	hospital	NN
cord-007444-c9vu8ako	428	26	admissions	admission	NNS
cord-007444-c9vu8ako	428	27	for	for	IN
cord-007444-c9vu8ako	428	28	the	the	DT
cord-007444-c9vu8ako	428	29	elderly	elderly	JJ
cord-007444-c9vu8ako	428	30	in	in	IN
cord-007444-c9vu8ako	428	31	Detroit	Detroit	NNP
cord-007444-c9vu8ako	428	32	,	,	,
cord-007444-c9vu8ako	428	33	Michigan	Michigan	NNP
cord-007444-c9vu8ako	428	34	Hospital	Hospital	NNP
cord-007444-c9vu8ako	428	35	and	and	CC
cord-007444-c9vu8ako	428	36	1-year	1-year	CD
cord-007444-c9vu8ako	428	37	survival	survival	NN
cord-007444-c9vu8ako	428	38	of	of	IN
cord-007444-c9vu8ako	428	39	patients	patient	NNS
cord-007444-c9vu8ako	428	40	admitted	admit	VBN
cord-007444-c9vu8ako	428	41	to	to	IN
cord-007444-c9vu8ako	428	42	intensive	intensive	JJ
cord-007444-c9vu8ako	428	43	care	care	NN
cord-007444-c9vu8ako	428	44	units	unit	NNS
cord-007444-c9vu8ako	428	45	with	with	IN
cord-007444-c9vu8ako	428	46	acute	acute	JJ
cord-007444-c9vu8ako	428	47	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	428	48	of	of	IN
cord-007444-c9vu8ako	428	49	chronic	chronic	JJ
cord-007444-c9vu8ako	428	50	obstructive	obstructive	JJ
cord-007444-c9vu8ako	428	51	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	428	52	disease	disease	NN
cord-007444-c9vu8ako	428	53	Austrian	Austrian	NNP
cord-007444-c9vu8ako	428	54	R	r	NN
cord-007444-c9vu8ako	429	1	The	the	DT
cord-007444-c9vu8ako	429	2	protective	protective	JJ
cord-007444-c9vu8ako	429	3	efficacy	efficacy	NN
cord-007444-c9vu8ako	429	4	of	of	IN
cord-007444-c9vu8ako	429	5	polyvalent	polyvalent	JJ
cord-007444-c9vu8ako	429	6	pneumoccocal	pneumoccocal	NNP
cord-007444-c9vu8ako	429	7	polysaccharide	polysaccharide	NN
cord-007444-c9vu8ako	429	8	vaccine	vaccine	NN
cord-007444-c9vu8ako	429	9	Epidemiology	epidemiology	NN
cord-007444-c9vu8ako	429	10	of	of	IN
cord-007444-c9vu8ako	429	11	chronic	chronic	JJ
cord-007444-c9vu8ako	429	12	obstructive	obstructive	JJ
cord-007444-c9vu8ako	429	13	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	429	14	disease	disease	NN
cord-007444-c9vu8ako	429	15	Decreased	decrease	VBD
cord-007444-c9vu8ako	429	16	duration	duration	NN
cord-007444-c9vu8ako	429	17	of	of	IN
cord-007444-c9vu8ako	429	18	emergency	emergency	NN
cord-007444-c9vu8ako	429	19	department	department	NN
cord-007444-c9vu8ako	429	20	treatment	treatment	NN
cord-007444-c9vu8ako	429	21	of	of	IN
cord-007444-c9vu8ako	429	22	chronic	chronic	JJ
cord-007444-c9vu8ako	429	23	obstructive	obstructive	JJ
cord-007444-c9vu8ako	429	24	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	429	25	disease	disease	NN
cord-007444-c9vu8ako	429	26	exacerba	exacerba	NN
cord-007444-c9vu8ako	429	27	tions	tion	NNS
cord-007444-c9vu8ako	429	28	with	with	IN
cord-007444-c9vu8ako	429	29	the	the	DT
cord-007444-c9vu8ako	429	30	addition	addition	NN
cord-007444-c9vu8ako	429	31	of	of	IN
cord-007444-c9vu8ako	429	32	ipratropium	ipratropium	NN
cord-007444-c9vu8ako	429	33	bromide	bromide	NN
cord-007444-c9vu8ako	429	34	to	to	IN
cord-007444-c9vu8ako	430	1	P	p	NN
cord-007444-c9vu8ako	430	2	-	-	HYPH
cord-007444-c9vu8ako	430	3	agonist	agonist	NN
cord-007444-c9vu8ako	430	4	therapy	therapy	NN
cord-007444-c9vu8ako	430	5	Optimal	Optimal	NNP
cord-007444-c9vu8ako	430	6	pharmacologic	pharmacologic	JJ
cord-007444-c9vu8ako	430	7	treatment	treatment	NN
cord-007444-c9vu8ako	430	8	of	of	IN
cord-007444-c9vu8ako	430	9	the	the	DT
cord-007444-c9vu8ako	430	10	critically	critically	RB
cord-007444-c9vu8ako	430	11	ill	ill	JJ
cord-007444-c9vu8ako	430	12	patient	patient	NN
cord-007444-c9vu8ako	430	13	with	with	IN
cord-007444-c9vu8ako	430	14	obstructive	obstructive	JJ
cord-007444-c9vu8ako	430	15	airways	airway	NNS
cord-007444-c9vu8ako	430	16	disease	disease	NN
cord-007444-c9vu8ako	430	17	Interactions	interaction	NNS
cord-007444-c9vu8ako	430	18	between	between	IN
cord-007444-c9vu8ako	430	19	viruses	virus	NNS
cord-007444-c9vu8ako	430	20	and	and	CC
cord-007444-c9vu8ako	430	21	bacteria	bacteria	NNS
cord-007444-c9vu8ako	430	22	in	in	IN
cord-007444-c9vu8ako	430	23	patients	patient	NNS
cord-007444-c9vu8ako	430	24	with	with	IN
cord-007444-c9vu8ako	430	25	chronic	chronic	JJ
cord-007444-c9vu8ako	430	26	bronchitis	bronchitis	NNP
cord-007444-c9vu8ako	430	27	Association	Association	NNP
cord-007444-c9vu8ako	430	28	of	of	IN
cord-007444-c9vu8ako	430	29	viral	viral	JJ
cord-007444-c9vu8ako	430	30	and	and	CC
cord-007444-c9vu8ako	430	31	Mycoplusma	Mycoplusma	NNP
cord-007444-c9vu8ako	430	32	pneumoniae	pneumoniae	NN
cord-007444-c9vu8ako	430	33	infections	infection	NNS
cord-007444-c9vu8ako	430	34	with	with	IN
cord-007444-c9vu8ako	430	35	acute	acute	JJ
cord-007444-c9vu8ako	430	36	respiratory	respiratory	JJ
cord-007444-c9vu8ako	430	37	illness	illness	NN
cord-007444-c9vu8ako	430	38	in	in	IN
cord-007444-c9vu8ako	430	39	patients	patient	NNS
cord-007444-c9vu8ako	430	40	with	with	IN
cord-007444-c9vu8ako	430	41	chronic	chronic	JJ
cord-007444-c9vu8ako	430	42	obstructive	obstructive	JJ
cord-007444-c9vu8ako	430	43	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	430	44	disease	disease	NN
cord-007444-c9vu8ako	430	45	Haemophilus	haemophilus	NN
cord-007444-c9vu8ako	430	46	influenzae	influenzae	NN
cord-007444-c9vu8ako	430	47	and	and	CC
cord-007444-c9vu8ako	430	48	Haemophilus	haemophilus	JJ
cord-007444-c9vu8ako	430	49	parainfluenzae	parainfluenzae	NNS
cord-007444-c9vu8ako	430	50	in	in	IN
cord-007444-c9vu8ako	430	51	chronic	chronic	JJ
cord-007444-c9vu8ako	430	52	obstructive	obstructive	JJ
cord-007444-c9vu8ako	430	53	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	430	54	disease	disease	NN
cord-007444-c9vu8ako	430	55	Bronchial	bronchial	JJ
cord-007444-c9vu8ako	430	56	microbial	microbial	JJ
cord-007444-c9vu8ako	430	57	patterns	pattern	NNS
cord-007444-c9vu8ako	430	58	in	in	IN
cord-007444-c9vu8ako	430	59	severe	severe	JJ
cord-007444-c9vu8ako	430	60	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	430	61	of	of	IN
cord-007444-c9vu8ako	430	62	chronic	chronic	JJ
cord-007444-c9vu8ako	430	63	obstructive	obstructive	JJ
cord-007444-c9vu8ako	430	64	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	430	65	disease	disease	NN
cord-007444-c9vu8ako	430	66	(	(	-LRB-
cord-007444-c9vu8ako	430	67	COPD	COPD	NNP
cord-007444-c9vu8ako	430	68	)	)	-RRB-
cord-007444-c9vu8ako	430	69	requiring	require	VBG
cord-007444-c9vu8ako	430	70	mechanical	mechanical	JJ
cord-007444-c9vu8ako	430	71	ventilation	ventilation	NN
cord-007444-c9vu8ako	430	72	Stark	Stark	NNP
cord-007444-c9vu8ako	430	73	JE	JE	NNP
cord-007444-c9vu8ako	430	74	,	,	,
cord-007444-c9vu8ako	430	75	Heath	Heath	NNP
cord-007444-c9vu8ako	430	76	RE	RE	NNP
cord-007444-c9vu8ako	430	77	,	,	,
cord-007444-c9vu8ako	430	78	Curwen	Curwen	NNP
cord-007444-c9vu8ako	430	79	MP	MP	NNP
cord-007444-c9vu8ako	430	80	:	:	:
cord-007444-c9vu8ako	430	81	Infection	infection	NN
cord-007444-c9vu8ako	430	82	with	with	IN
cord-007444-c9vu8ako	430	83	influenza	influenza	NN
cord-007444-c9vu8ako	430	84	and	and	CC
cord-007444-c9vu8ako	430	85	parainfluenza	parainfluenza	NN
cord-007444-c9vu8ako	430	86	viruses	virus	NNS
cord-007444-c9vu8ako	430	87	in	in	IN
cord-007444-c9vu8ako	430	88	chronic	chronic	JJ
cord-007444-c9vu8ako	430	89	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	430	90	Rhinovirus	Rhinovirus	NNP
cord-007444-c9vu8ako	430	91	infection	infection	NN
cord-007444-c9vu8ako	430	92	in	in	IN
cord-007444-c9vu8ako	430	93	acute	acute	JJ
cord-007444-c9vu8ako	430	94	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	430	95	of	of	IN
cord-007444-c9vu8ako	430	96	chronic	chronic	JJ
cord-007444-c9vu8ako	430	97	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	430	98	:	:	:
cord-007444-c9vu8ako	431	1	A	a	DT
cord-007444-c9vu8ako	431	2	controlled	control	VBN
cord-007444-c9vu8ako	431	3	prospective	prospective	JJ
cord-007444-c9vu8ako	431	4	study	study	NN
cord-007444-c9vu8ako	431	5	Hypercapnia	Hypercapnia	NNP
cord-007444-c9vu8ako	431	6	during	during	IN
cord-007444-c9vu8ako	431	7	oxygen	oxygen	NN
cord-007444-c9vu8ako	431	8	therapy	therapy	NN
cord-007444-c9vu8ako	431	9	in	in	IN
cord-007444-c9vu8ako	431	10	airways	airways	NNP
cord-007444-c9vu8ako	431	11	obstruction	obstruction	NN
cord-007444-c9vu8ako	431	12	:	:	:
cord-007444-c9vu8ako	431	13	A	a	DT
cord-007444-c9vu8ako	431	14	reappraisal	reappraisal	NN
cord-007444-c9vu8ako	432	1	Aerosol	aerosol	NN
cord-007444-c9vu8ako	432	2	bronchodilator	bronchodilator	NN
cord-007444-c9vu8ako	432	3	delivery	delivery	NN
cord-007444-c9vu8ako	432	4	methods	method	NNS
cord-007444-c9vu8ako	432	5	:	:	:
cord-007444-c9vu8ako	433	1	Relative	relative	JJ
cord-007444-c9vu8ako	433	2	impact	impact	NN
cord-007444-c9vu8ako	433	3	on	on	IN
cord-007444-c9vu8ako	433	4	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	433	5	function	function	NN
cord-007444-c9vu8ako	433	6	and	and	CC
cord-007444-c9vu8ako	433	7	cost	cost	NN
cord-007444-c9vu8ako	433	8	of	of	IN
cord-007444-c9vu8ako	433	9	respiratory	respiratory	JJ
cord-007444-c9vu8ako	433	10	care	care	NN
cord-007444-c9vu8ako	433	11	Air	air	NN
cord-007444-c9vu8ako	433	12	pollution	pollution	NN
cord-007444-c9vu8ako	433	13	and	and	CC
cord-007444-c9vu8ako	433	14	emergency	emergency	NN
cord-007444-c9vu8ako	433	15	room	room	NN
cord-007444-c9vu8ako	433	16	admissions	admission	NNS
cord-007444-c9vu8ako	433	17	for	for	IN
cord-007444-c9vu8ako	433	18	chronic	chronic	JJ
cord-007444-c9vu8ako	433	19	obstructive	obstructive	JJ
cord-007444-c9vu8ako	433	20	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	433	21	disease	disease	NN
cord-007444-c9vu8ako	433	22	:	:	:
cord-007444-c9vu8ako	434	1	A	a	DT
cord-007444-c9vu8ako	434	2	5-year	5-year	CD
cord-007444-c9vu8ako	434	3	study	study	NN
cord-007444-c9vu8ako	434	4	Comparison	comparison	NN
cord-007444-c9vu8ako	434	5	of	of	IN
cord-007444-c9vu8ako	434	6	anticholinergic	anticholinergic	JJ
cord-007444-c9vu8ako	434	7	bronchodilator	bronchodilator	NN
cord-007444-c9vu8ako	434	8	ipratropium	ipratropium	NN
cord-007444-c9vu8ako	434	9	bromide	bromide	NN
cord-007444-c9vu8ako	434	10	with	with	IN
cord-007444-c9vu8ako	434	11	metaproterenol	metaproterenol	NN
cord-007444-c9vu8ako	434	12	in	in	IN
cord-007444-c9vu8ako	434	13	chronic	chronic	JJ
cord-007444-c9vu8ako	434	14	obstructive	obstructive	JJ
cord-007444-c9vu8ako	434	15	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	434	16	disease	disease	NN
cord-007444-c9vu8ako	434	17	:	:	:
cord-007444-c9vu8ako	435	1	A	a	DT
cord-007444-c9vu8ako	435	2	90-day	90-day	CD
cord-007444-c9vu8ako	435	3	multicentre	multicentre	NNP
cord-007444-c9vu8ako	435	4	study	study	VB
cord-007444-c9vu8ako	435	5	An	an	DT
cord-007444-c9vu8ako	435	6	alteration	alteration	NN
cord-007444-c9vu8ako	435	7	in	in	IN
cord-007444-c9vu8ako	435	8	the	the	DT
cord-007444-c9vu8ako	435	9	host	host	NN
cord-007444-c9vu8ako	435	10	-	-	HYPH
cord-007444-c9vu8ako	435	11	parasite	parasite	NN
cord-007444-c9vu8ako	435	12	relationship	relationship	NN
cord-007444-c9vu8ako	435	13	in	in	IN
cord-007444-c9vu8ako	435	14	subjects	subject	NNS
cord-007444-c9vu8ako	435	15	with	with	IN
cord-007444-c9vu8ako	435	16	chronic	chronic	JJ
cord-007444-c9vu8ako	435	17	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	435	18	prone	prone	JJ
cord-007444-c9vu8ako	435	19	to	to	IN
cord-007444-c9vu8ako	435	20	recurrent	recurrent	JJ
cord-007444-c9vu8ako	435	21	episodes	episode	NNS
cord-007444-c9vu8ako	435	22	of	of	IN
cord-007444-c9vu8ako	435	23	acute	acute	JJ
cord-007444-c9vu8ako	435	24	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	436	1	The	the	DT
cord-007444-c9vu8ako	436	2	Smoking	Smoking	NNP
cord-007444-c9vu8ako	436	3	Cessation	Cessation	NNP
cord-007444-c9vu8ako	436	4	Clinical	Clinical	NNP
cord-007444-c9vu8ako	436	5	Practice	Practice	NNP
cord-007444-c9vu8ako	436	6	Guideline	Guideline	NNP
cord-007444-c9vu8ako	436	7	Panel	Panel	NNP
cord-007444-c9vu8ako	436	8	and	and	CC
cord-007444-c9vu8ako	436	9	Staff	Staff	NNP
cord-007444-c9vu8ako	436	10	:	:	:
cord-007444-c9vu8ako	437	1	The	the	DT
cord-007444-c9vu8ako	437	2	Agency	Agency	NNP
cord-007444-c9vu8ako	437	3	for	for	IN
cord-007444-c9vu8ako	437	4	Health	Health	NNP
cord-007444-c9vu8ako	437	5	Care	Care	NNP
cord-007444-c9vu8ako	437	6	Policy	Policy	NNP
cord-007444-c9vu8ako	437	7	and	and	CC
cord-007444-c9vu8ako	437	8	Research	Research	NNP
cord-007444-c9vu8ako	437	9	Smoking	Smoking	NNP
cord-007444-c9vu8ako	437	10	Cessation	Cessation	NNP
cord-007444-c9vu8ako	437	11	clinical	clinical	JJ
cord-007444-c9vu8ako	437	12	practice	practice	NN
cord-007444-c9vu8ako	437	13	guideline	guideline	NN
cord-007444-c9vu8ako	437	14	Controlled	control	VBN
cord-007444-c9vu8ako	437	15	trial	trial	NN
cord-007444-c9vu8ako	437	16	of	of	IN
cord-007444-c9vu8ako	437	17	oral	oral	JJ
cord-007444-c9vu8ako	437	18	prednisone	prednisone	NN
cord-007444-c9vu8ako	437	19	in	in	IN
cord-007444-c9vu8ako	437	20	outpatients	outpatient	NNS
cord-007444-c9vu8ako	437	21	with	with	IN
cord-007444-c9vu8ako	437	22	acute	acute	JJ
cord-007444-c9vu8ako	437	23	COPD	COPD	NNP
cord-007444-c9vu8ako	437	24	exacerbation	exacerbation	NN
cord-007444-c9vu8ako	437	25	Predictors	Predictors	NNP
cord-007444-c9vu8ako	437	26	of	of	IN
cord-007444-c9vu8ako	437	27	mortality	mortality	NN
cord-007444-c9vu8ako	437	28	in	in	IN
cord-007444-c9vu8ako	437	29	chronic	chronic	JJ
cord-007444-c9vu8ako	437	30	obstructive	obstructive	JJ
cord-007444-c9vu8ako	437	31	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	437	32	disease	disease	NN
cord-007444-c9vu8ako	437	33	:	:	:
cord-007444-c9vu8ako	438	1	A	a	DT
cord-007444-c9vu8ako	438	2	15-year	15-year	JJ
cord-007444-c9vu8ako	438	3	follow	follow	NN
cord-007444-c9vu8ako	438	4	-	-	HYPH
cord-007444-c9vu8ako	438	5	up	up	NN
cord-007444-c9vu8ako	438	6	study	study	NN
cord-007444-c9vu8ako	439	1	A	a	DT
cord-007444-c9vu8ako	439	2	review	review	NN
cord-007444-c9vu8ako	439	3	and	and	CC
cord-007444-c9vu8ako	439	4	economic	economic	JJ
cord-007444-c9vu8ako	439	5	evaluation	evaluation	NN
cord-007444-c9vu8ako	439	6	of	of	IN
cord-007444-c9vu8ako	439	7	bronchodilator	bronchodilator	NN
cord-007444-c9vu8ako	439	8	delivery	delivery	NN
cord-007444-c9vu8ako	439	9	methods	method	NNS
cord-007444-c9vu8ako	439	10	in	in	IN
cord-007444-c9vu8ako	439	11	hospitalized	hospitalize	VBN
cord-007444-c9vu8ako	439	12	patients	patient	NNS
cord-007444-c9vu8ako	439	13	tor	tor	NN
cord-007444-c9vu8ako	439	14	delivery	delivery	NN
cord-007444-c9vu8ako	439	15	in	in	IN
cord-007444-c9vu8ako	439	16	acute	acute	JJ
cord-007444-c9vu8ako	439	17	airflow	airflow	NN
cord-007444-c9vu8ako	439	18	obstruction	obstruction	NN
cord-007444-c9vu8ako	439	19	-	-	:
cord-007444-c9vu8ako	439	20	a	a	DT
cord-007444-c9vu8ako	439	21	metaanalysis	metaanalysis	NN
cord-007444-c9vu8ako	439	22	Theophylline	theophylline	NN
cord-007444-c9vu8ako	439	23	:	:	:
cord-007444-c9vu8ako	439	24	Recent	recent	JJ
cord-007444-c9vu8ako	439	25	advances	advance	NNS
cord-007444-c9vu8ako	439	26	in	in	IN
cord-007444-c9vu8ako	439	27	the	the	DT
cord-007444-c9vu8ako	439	28	understanding	understanding	NN
cord-007444-c9vu8ako	439	29	of	of	IN
cord-007444-c9vu8ako	439	30	its	-PRON-	PRP$
cord-007444-c9vu8ako	439	31	mode	mode	NN
cord-007444-c9vu8ako	439	32	of	of	IN
cord-007444-c9vu8ako	439	33	action	action	NN
cord-007444-c9vu8ako	439	34	and	and	CC
cord-007444-c9vu8ako	439	35	uses	use	VBZ
cord-007444-c9vu8ako	439	36	in	in	IN
cord-007444-c9vu8ako	439	37	clinical	clinical	JJ
cord-007444-c9vu8ako	439	38	practice	practice	NN
cord-007444-c9vu8ako	440	1	Subcutaneous	subcutaneous	JJ
cord-007444-c9vu8ako	440	2	administration	administration	NN
cord-007444-c9vu8ako	440	3	of	of	IN
cord-007444-c9vu8ako	440	4	hyaluronan	hyaluronan	NNP
cord-007444-c9vu8ako	440	5	reduces	reduce	VBZ
cord-007444-c9vu8ako	440	6	the	the	DT
cord-007444-c9vu8ako	440	7	number	number	NN
cord-007444-c9vu8ako	440	8	of	of	IN
cord-007444-c9vu8ako	440	9	infectious	infectious	JJ
cord-007444-c9vu8ako	440	10	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	440	11	in	in	IN
cord-007444-c9vu8ako	440	12	patients	patient	NNS
cord-007444-c9vu8ako	440	13	with	with	IN
cord-007444-c9vu8ako	440	14	chronic	chronic	JJ
cord-007444-c9vu8ako	440	15	bronchitis	bronchitis	NN
cord-007444-c9vu8ako	440	16	Hypercapnia	Hypercapnia	NNP
cord-007444-c9vu8ako	440	17	Outcome	outcome	VBP
cord-007444-c9vu8ako	440	18	from	from	IN
cord-007444-c9vu8ako	440	19	respiratory	respiratory	JJ
cord-007444-c9vu8ako	440	20	failure	failure	NN
cord-007444-c9vu8ako	440	21	Nutritional	nutritional	JJ
cord-007444-c9vu8ako	440	22	aspects	aspect	NNS
cord-007444-c9vu8ako	440	23	of	of	IN
cord-007444-c9vu8ako	440	24	chronic	chronic	JJ
cord-007444-c9vu8ako	440	25	obstructive	obstructive	JJ
cord-007444-c9vu8ako	440	26	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	440	27	disease	disease	NN
cord-007444-c9vu8ako	441	1	The	the	DT
cord-007444-c9vu8ako	441	2	biology	biology	NN
cord-007444-c9vu8ako	441	3	of	of	IN
cord-007444-c9vu8ako	441	4	bacterial	bacterial	JJ
cord-007444-c9vu8ako	441	5	colonization	colonization	NN
cord-007444-c9vu8ako	441	6	and	and	CC
cord-007444-c9vu8ako	441	7	invasion	invasion	NN
cord-007444-c9vu8ako	441	8	of	of	IN
cord-007444-c9vu8ako	441	9	the	the	DT
cord-007444-c9vu8ako	441	10	respiratory	respiratory	JJ
cord-007444-c9vu8ako	441	11	mucosa	mucosa	NN
cord-007444-c9vu8ako	442	1	The	the	DT
cord-007444-c9vu8ako	442	2	role	role	NN
cord-007444-c9vu8ako	442	3	of	of	IN
cord-007444-c9vu8ako	442	4	corticosteroids	corticosteroid	NNS
cord-007444-c9vu8ako	442	5	in	in	IN
cord-007444-c9vu8ako	442	6	acute	acute	JJ
cord-007444-c9vu8ako	442	7	exacerbations	exacerbation	NNS
cord-007444-c9vu8ako	442	8	of	of	IN
cord-007444-c9vu8ako	442	9	chronic	chronic	JJ
cord-007444-c9vu8ako	442	10	obstructive	obstructive	JJ
cord-007444-c9vu8ako	442	11	pulmonary	pulmonary	JJ
cord-007444-c9vu8ako	442	12	disease	disease	NN
cord-007444-c9vu8ako	442	13	(	(	-LRB-
cord-007444-c9vu8ako	442	14	Cochrane	Cochrane	NNP
cord-007444-c9vu8ako	442	15	review	review	NN
cord-007444-c9vu8ako	442	16	)	)	-RRB-
cord-007444-c9vu8ako	442	17	.	.	.
cord-007444-c9vu8ako	443	1	The	the	DT
cord-007444-c9vu8ako	443	2	Cochrane	Cochrane	NNP
cord-007444-c9vu8ako	443	3	Library	Library	NNP
cord-007444-c9vu8ako	443	4	Aminophylline	Aminophylline	NNP
cord-007444-c9vu8ako	443	5	therapy	therapy	NN
cord-007444-c9vu8ako	443	6	for	for	IN
cord-007444-c9vu8ako	443	7	acute	acute	JJ
cord-007444-c9vu8ako	443	8	bronchospastic	bronchospastic	JJ
cord-007444-c9vu8ako	443	9	disease	disease	NN
cord-007444-c9vu8ako	443	10	in	in	IN
cord-007444-c9vu8ako	443	11	the	the	DT
cord-007444-c9vu8ako	443	12	emergency	emergency	NN
cord-007444-c9vu8ako	443	13	room	room	NN
cord-007444-c9vu8ako	444	1	A	a	DT
cord-007444-c9vu8ako	444	2	short	short	JJ
cord-007444-c9vu8ako	444	3	-	-	HYPH
cord-007444-c9vu8ako	444	4	term	term	NN
cord-007444-c9vu8ako	444	5	follow	follow	NN
cord-007444-c9vu8ako	444	6	-	-	HYPH
cord-007444-c9vu8ako	444	7	up	up	NN
cord-007444-c9vu8ako	444	8	study	study	NN
cord-007444-c9vu8ako	444	9	on	on	IN
cord-007444-c9vu8ako	444	10	ex	ex	JJ
cord-007444-c9vu8ako	444	11	-	-	JJ
cord-007444-c9vu8ako	444	12	cigarette	cigarette	JJ
cord-007444-c9vu8ako	444	13	smokers	smoker	NNS
cord-007444-c9vu8ako	444	14	:	:	:
cord-007444-c9vu8ako	444	15	With	with	IN
cord-007444-c9vu8ako	444	16	special	special	JJ
cord-007444-c9vu8ako	444	17	emphasis	emphasis	NN
cord-007444-c9vu8ako	444	18	on	on	IN
cord-007444-c9vu8ako	444	19	persistent	persistent	JJ
cord-007444-c9vu8ako	444	20	cough	cough	NN
cord-007444-c9vu8ako	444	21	and	and	CC
cord-007444-c9vu8ako	444	22	weight	weight	NN
cord-007444-c9vu8ako	444	23	gain	gain	NN