id sid tid token lemma pos cord-295206-vetdsk48 1 1 key key JJ cord-295206-vetdsk48 1 2 : : : cord-295206-vetdsk48 1 3 cord-295206-vetdsk48 cord-295206-vetdsk48 NNS cord-295206-vetdsk48 1 4 authors author NNS cord-295206-vetdsk48 1 5 : : : cord-295206-vetdsk48 1 6 Woodfork Woodfork NNP cord-295206-vetdsk48 1 7 , , , cord-295206-vetdsk48 1 8 Karen Karen NNP cord-295206-vetdsk48 1 9 title title NN cord-295206-vetdsk48 1 10 : : : cord-295206-vetdsk48 2 1 Bronchitis bronchitis NN cord-295206-vetdsk48 2 2 date date NN cord-295206-vetdsk48 2 3 : : : cord-295206-vetdsk48 2 4 2008 2008 CD cord-295206-vetdsk48 2 5 - - SYM cord-295206-vetdsk48 2 6 01 01 CD cord-295206-vetdsk48 2 7 - - SYM cord-295206-vetdsk48 2 8 10 10 CD cord-295206-vetdsk48 2 9 journal journal NN cord-295206-vetdsk48 2 10 : : : cord-295206-vetdsk48 2 11 xPharm xPharm NNP cord-295206-vetdsk48 2 12 : : : cord-295206-vetdsk48 3 1 The the DT cord-295206-vetdsk48 3 2 Comprehensive Comprehensive NNP cord-295206-vetdsk48 3 3 Pharmacology Pharmacology NNP cord-295206-vetdsk48 3 4 Reference Reference NNP cord-295206-vetdsk48 3 5 DOI DOI NNP cord-295206-vetdsk48 3 6 : : : cord-295206-vetdsk48 3 7 10.1016 10.1016 CD cord-295206-vetdsk48 3 8 / / SYM cord-295206-vetdsk48 3 9 b978 b978 NNP cord-295206-vetdsk48 3 10 - - HYPH cord-295206-vetdsk48 3 11 008055232 008055232 CD cord-295206-vetdsk48 4 1 -3.63026 -3.63026 NN cord-295206-vetdsk48 4 2 - - HYPH cord-295206-vetdsk48 4 3 0 0 CD cord-295206-vetdsk48 4 4 sha sha NN cord-295206-vetdsk48 4 5 : : : cord-295206-vetdsk48 5 1 6be9271f722cb61db36310d6c43fa21666a3c0fe 6be9271f722cb61db36310d6c43fa21666a3c0fe CD cord-295206-vetdsk48 6 1 doc_id doc_id CD cord-295206-vetdsk48 6 2 : : : cord-295206-vetdsk48 6 3 295206 295206 CD cord-295206-vetdsk48 6 4 cord_uid cord_uid NNS cord-295206-vetdsk48 6 5 : : : cord-295206-vetdsk48 7 1 vetdsk48 vetdsk48 NNP cord-295206-vetdsk48 7 2 Bronchitis Bronchitis NNP cord-295206-vetdsk48 7 3 is be VBZ cord-295206-vetdsk48 7 4 characterized characterize VBN cord-295206-vetdsk48 7 5 by by IN cord-295206-vetdsk48 7 6 bronchial bronchial JJ cord-295206-vetdsk48 7 7 inflammation inflammation NN cord-295206-vetdsk48 7 8 that that WDT cord-295206-vetdsk48 7 9 results result VBZ cord-295206-vetdsk48 7 10 in in IN cord-295206-vetdsk48 7 11 … … NFP cord-295206-vetdsk48 8 1 Bronchitis bronchitis NN cord-295206-vetdsk48 8 2 is be VBZ cord-295206-vetdsk48 8 3 characterized characterize VBN cord-295206-vetdsk48 8 4 by by IN cord-295206-vetdsk48 8 5 bronchial bronchial JJ cord-295206-vetdsk48 8 6 inflammation inflammation NN cord-295206-vetdsk48 8 7 that that WDT cord-295206-vetdsk48 8 8 results result VBZ cord-295206-vetdsk48 8 9 in in IN cord-295206-vetdsk48 8 10 cough cough NN cord-295206-vetdsk48 8 11 and and CC cord-295206-vetdsk48 8 12 sputum sputum NN cord-295206-vetdsk48 8 13 production production NN cord-295206-vetdsk48 8 14 . . . cord-295206-vetdsk48 9 1 This this DT cord-295206-vetdsk48 9 2 inflammation inflammation NN cord-295206-vetdsk48 9 3 can can MD cord-295206-vetdsk48 9 4 be be VB cord-295206-vetdsk48 9 5 acute acute JJ cord-295206-vetdsk48 9 6 in in IN cord-295206-vetdsk48 9 7 nature nature NN cord-295206-vetdsk48 9 8 , , , cord-295206-vetdsk48 9 9 usually usually RB cord-295206-vetdsk48 9 10 resulting result VBG cord-295206-vetdsk48 9 11 from from IN cord-295206-vetdsk48 9 12 a a DT cord-295206-vetdsk48 9 13 viral viral JJ cord-295206-vetdsk48 9 14 infection infection NN cord-295206-vetdsk48 9 15 , , , cord-295206-vetdsk48 9 16 or or CC cord-295206-vetdsk48 9 17 it -PRON- PRP cord-295206-vetdsk48 9 18 may may MD cord-295206-vetdsk48 9 19 be be VB cord-295206-vetdsk48 9 20 a a DT cord-295206-vetdsk48 9 21 long long RB cord-295206-vetdsk48 9 22 - - HYPH cord-295206-vetdsk48 9 23 standing stand VBG cord-295206-vetdsk48 9 24 manifestation manifestation NN cord-295206-vetdsk48 9 25 of of IN cord-295206-vetdsk48 9 26 chronic chronic JJ cord-295206-vetdsk48 9 27 obstructive obstructive JJ cord-295206-vetdsk48 9 28 pulmonary pulmonary JJ cord-295206-vetdsk48 9 29 disease disease NN cord-295206-vetdsk48 9 30 . . . cord-295206-vetdsk48 10 1 Acute acute JJ cord-295206-vetdsk48 10 2 infectious infectious JJ cord-295206-vetdsk48 10 3 bronchitis bronchitis NN cord-295206-vetdsk48 10 4 differs differ VBZ cord-295206-vetdsk48 10 5 from from IN cord-295206-vetdsk48 10 6 chronic chronic JJ cord-295206-vetdsk48 10 7 bronchitis bronchitis NN cord-295206-vetdsk48 10 8 with with IN cord-295206-vetdsk48 10 9 respect respect NN cord-295206-vetdsk48 10 10 to to IN cord-295206-vetdsk48 10 11 etiology etiology NN cord-295206-vetdsk48 10 12 , , , cord-295206-vetdsk48 10 13 pathophysiology pathophysiology NN cord-295206-vetdsk48 10 14 , , , cord-295206-vetdsk48 10 15 and and CC cord-295206-vetdsk48 10 16 treatment treatment NN cord-295206-vetdsk48 10 17 . . . cord-295206-vetdsk48 11 1 Acute acute JJ cord-295206-vetdsk48 11 2 bronchitis bronchitis NN cord-295206-vetdsk48 11 3 is be VBZ cord-295206-vetdsk48 11 4 among among IN cord-295206-vetdsk48 11 5 the the DT cord-295206-vetdsk48 11 6 most most RBS cord-295206-vetdsk48 11 7 frequent frequent JJ cord-295206-vetdsk48 11 8 reasons reason NNS cord-295206-vetdsk48 11 9 for for IN cord-295206-vetdsk48 11 10 visits visit NNS cord-295206-vetdsk48 11 11 to to IN cord-295206-vetdsk48 11 12 the the DT cord-295206-vetdsk48 11 13 physician physician NN cord-295206-vetdsk48 11 14 's 's POS cord-295206-vetdsk48 11 15 office office NN cord-295206-vetdsk48 11 16 . . . cord-295206-vetdsk48 12 1 It -PRON- PRP cord-295206-vetdsk48 12 2 can can MD cord-295206-vetdsk48 12 3 be be VB cord-295206-vetdsk48 12 4 defined define VBN cord-295206-vetdsk48 12 5 as as IN cord-295206-vetdsk48 12 6 an an DT cord-295206-vetdsk48 12 7 infectious infectious JJ cord-295206-vetdsk48 12 8 , , , cord-295206-vetdsk48 12 9 generally generally RB cord-295206-vetdsk48 12 10 viral viral JJ cord-295206-vetdsk48 12 11 , , , cord-295206-vetdsk48 12 12 respiratory respiratory JJ cord-295206-vetdsk48 12 13 illness illness NN cord-295206-vetdsk48 12 14 that that WDT cord-295206-vetdsk48 12 15 last last JJ cord-295206-vetdsk48 12 16 for for IN cord-295206-vetdsk48 12 17 1 1 CD cord-295206-vetdsk48 12 18 - - SYM cord-295206-vetdsk48 12 19 3 3 CD cord-295206-vetdsk48 12 20 weeks week NNS cord-295206-vetdsk48 12 21 that that WDT cord-295206-vetdsk48 12 22 occurs occur VBZ cord-295206-vetdsk48 12 23 in in IN cord-295206-vetdsk48 12 24 an an DT cord-295206-vetdsk48 12 25 otherwise otherwise RB cord-295206-vetdsk48 12 26 healthy healthy JJ cord-295206-vetdsk48 12 27 adult adult NN cord-295206-vetdsk48 12 28 with with IN cord-295206-vetdsk48 12 29 cough cough NN cord-295206-vetdsk48 12 30 as as IN cord-295206-vetdsk48 12 31 the the DT cord-295206-vetdsk48 12 32 predominate predominate NNS cord-295206-vetdsk48 12 33 feature feature VBP cord-295206-vetdsk48 12 34 Gonzales Gonzales NNP cord-295206-vetdsk48 12 35 and and CC cord-295206-vetdsk48 12 36 Sande Sande NNP cord-295206-vetdsk48 12 37 ( ( -LRB- cord-295206-vetdsk48 12 38 2000 2000 CD cord-295206-vetdsk48 12 39 ) ) -RRB- cord-295206-vetdsk48 12 40 . . . cord-295206-vetdsk48 13 1 In in IN cord-295206-vetdsk48 13 2 addition addition NN cord-295206-vetdsk48 13 3 to to TO cord-295206-vetdsk48 13 4 cough cough VB cord-295206-vetdsk48 13 5 and and CC cord-295206-vetdsk48 13 6 usually usually RB cord-295206-vetdsk48 13 7 sputum sputum JJ cord-295206-vetdsk48 13 8 production production NN cord-295206-vetdsk48 13 9 , , , cord-295206-vetdsk48 13 10 acute acute JJ cord-295206-vetdsk48 13 11 bronchitis bronchitis NN cord-295206-vetdsk48 13 12 frequently frequently RB cord-295206-vetdsk48 13 13 involves involve VBZ cord-295206-vetdsk48 13 14 upper upper JJ cord-295206-vetdsk48 13 15 respiratory respiratory JJ cord-295206-vetdsk48 13 16 symptoms symptom NNS cord-295206-vetdsk48 13 17 and and CC cord-295206-vetdsk48 13 18 constitutional constitutional JJ cord-295206-vetdsk48 13 19 complaints complaint NNS cord-295206-vetdsk48 13 20 , , , cord-295206-vetdsk48 13 21 such such JJ cord-295206-vetdsk48 13 22 as as IN cord-295206-vetdsk48 13 23 fatigue fatigue NN cord-295206-vetdsk48 13 24 and and CC cord-295206-vetdsk48 13 25 body body NN cord-295206-vetdsk48 13 26 aches ache NNS cord-295206-vetdsk48 13 27 . . . cord-295206-vetdsk48 14 1 An an DT cord-295206-vetdsk48 14 2 illness illness NN cord-295206-vetdsk48 14 3 comprised comprise VBN cord-295206-vetdsk48 14 4 of of IN cord-295206-vetdsk48 14 5 these these DT cord-295206-vetdsk48 14 6 symptoms symptom NNS cord-295206-vetdsk48 14 7 may may MD cord-295206-vetdsk48 14 8 be be VB cord-295206-vetdsk48 14 9 classified classify VBN cord-295206-vetdsk48 14 10 as as IN cord-295206-vetdsk48 14 11 acute acute JJ cord-295206-vetdsk48 14 12 bronchitis bronchitis NN cord-295206-vetdsk48 14 13 once once IN cord-295206-vetdsk48 14 14 the the DT cord-295206-vetdsk48 14 15 diagnosis diagnosis NN cord-295206-vetdsk48 14 16 of of IN cord-295206-vetdsk48 14 17 pneumonia pneumonia NN cord-295206-vetdsk48 14 18 is be VBZ cord-295206-vetdsk48 14 19 excluded exclude VBN cord-295206-vetdsk48 14 20 . . . cord-295206-vetdsk48 15 1 As as IN cord-295206-vetdsk48 15 2 a a DT cord-295206-vetdsk48 15 3 form form NN cord-295206-vetdsk48 15 4 of of IN cord-295206-vetdsk48 15 5 chronic chronic JJ cord-295206-vetdsk48 15 6 obstructive obstructive JJ cord-295206-vetdsk48 15 7 pulmonary pulmonary JJ cord-295206-vetdsk48 15 8 disease disease NN cord-295206-vetdsk48 15 9 ( ( -LRB- cord-295206-vetdsk48 15 10 COPD COPD NNP cord-295206-vetdsk48 15 11 ) ) -RRB- cord-295206-vetdsk48 15 12 , , , cord-295206-vetdsk48 15 13 chronic chronic JJ cord-295206-vetdsk48 15 14 bronchitis bronchitis NN cord-295206-vetdsk48 15 15 is be VBZ cord-295206-vetdsk48 15 16 characterized characterize VBN cord-295206-vetdsk48 15 17 by by IN cord-295206-vetdsk48 15 18 irreversible irreversible JJ cord-295206-vetdsk48 15 19 or or CC cord-295206-vetdsk48 15 20 incompletely incompletely RB cord-295206-vetdsk48 15 21 reversible reversible JJ cord-295206-vetdsk48 15 22 airway airway JJ cord-295206-vetdsk48 15 23 obstruction obstruction NN cord-295206-vetdsk48 15 24 that that WDT cord-295206-vetdsk48 15 25 produces produce VBZ cord-295206-vetdsk48 15 26 a a DT cord-295206-vetdsk48 15 27 decrease decrease NN cord-295206-vetdsk48 15 28 in in IN cord-295206-vetdsk48 15 29 maximal maximal JJ cord-295206-vetdsk48 15 30 expiratory expiratory NN cord-295206-vetdsk48 15 31 airflow airflow NN cord-295206-vetdsk48 15 32 Chitkara Chitkara NNP cord-295206-vetdsk48 15 33 and and CC cord-295206-vetdsk48 15 34 Sarinas Sarinas NNP cord-295206-vetdsk48 15 35 ( ( -LRB- cord-295206-vetdsk48 15 36 2002 2002 CD cord-295206-vetdsk48 15 37 ) ) -RRB- cord-295206-vetdsk48 15 38 . . . cord-295206-vetdsk48 16 1 The the DT cord-295206-vetdsk48 16 2 definition definition NN cord-295206-vetdsk48 16 3 of of IN cord-295206-vetdsk48 16 4 chronic chronic JJ cord-295206-vetdsk48 16 5 bronchitis bronchitis NN cord-295206-vetdsk48 16 6 is be VBZ cord-295206-vetdsk48 16 7 symptomatic symptomatic JJ cord-295206-vetdsk48 16 8 . . . cord-295206-vetdsk48 17 1 That that RB cord-295206-vetdsk48 17 2 is is RB cord-295206-vetdsk48 17 3 , , , cord-295206-vetdsk48 17 4 it -PRON- PRP cord-295206-vetdsk48 17 5 is be VBZ cord-295206-vetdsk48 17 6 a a DT cord-295206-vetdsk48 17 7 condition condition NN cord-295206-vetdsk48 17 8 that that WDT cord-295206-vetdsk48 17 9 results result VBZ cord-295206-vetdsk48 17 10 in in IN cord-295206-vetdsk48 17 11 a a DT cord-295206-vetdsk48 17 12 mucusproducing mucusproducing NN cord-295206-vetdsk48 17 13 cough cough NN cord-295206-vetdsk48 17 14 that that WDT cord-295206-vetdsk48 17 15 is be VBZ cord-295206-vetdsk48 17 16 present present JJ cord-295206-vetdsk48 17 17 for for IN cord-295206-vetdsk48 17 18 at at RB cord-295206-vetdsk48 17 19 least least JJS cord-295206-vetdsk48 17 20 3 3 CD cord-295206-vetdsk48 17 21 months month NNS cord-295206-vetdsk48 17 22 of of IN cord-295206-vetdsk48 17 23 the the DT cord-295206-vetdsk48 17 24 year year NN cord-295206-vetdsk48 17 25 for for IN cord-295206-vetdsk48 17 26 2 2 CD cord-295206-vetdsk48 17 27 consecutive consecutive JJ cord-295206-vetdsk48 17 28 years year NNS cord-295206-vetdsk48 17 29 and and CC cord-295206-vetdsk48 17 30 does do VBZ cord-295206-vetdsk48 17 31 not not RB cord-295206-vetdsk48 17 32 have have VB cord-295206-vetdsk48 17 33 some some DT cord-295206-vetdsk48 17 34 other other JJ cord-295206-vetdsk48 17 35 underlying underlie VBG cord-295206-vetdsk48 17 36 etiology etiology NN cord-295206-vetdsk48 17 37 such such JJ cord-295206-vetdsk48 17 38 as as IN cord-295206-vetdsk48 17 39 tuberculosisWisniewski tuberculosisWisniewski NNP cord-295206-vetdsk48 17 40 ( ( -LRB- cord-295206-vetdsk48 17 41 2003 2003 CD cord-295206-vetdsk48 17 42 ) ) -RRB- cord-295206-vetdsk48 17 43 . . . cord-295206-vetdsk48 18 1 Depending depend VBG cord-295206-vetdsk48 18 2 on on IN cord-295206-vetdsk48 18 3 its -PRON- PRP$ cord-295206-vetdsk48 18 4 severity severity NN cord-295206-vetdsk48 18 5 , , , cord-295206-vetdsk48 18 6 chronic chronic JJ cord-295206-vetdsk48 18 7 bronchitis bronchitis NN cord-295206-vetdsk48 18 8 may may MD cord-295206-vetdsk48 18 9 produce produce VB cord-295206-vetdsk48 18 10 minimal minimal JJ cord-295206-vetdsk48 18 11 to to IN cord-295206-vetdsk48 18 12 significant significant JJ cord-295206-vetdsk48 18 13 functional functional JJ cord-295206-vetdsk48 18 14 impairment impairment NN cord-295206-vetdsk48 18 15 . . . cord-295206-vetdsk48 19 1 Acute acute JJ cord-295206-vetdsk48 19 2 bronchitis bronchitis NN cord-295206-vetdsk48 19 3 is be VBZ cord-295206-vetdsk48 19 4 a a DT cord-295206-vetdsk48 19 5 form form NN cord-295206-vetdsk48 19 6 of of IN cord-295206-vetdsk48 19 7 lower low JJR cord-295206-vetdsk48 19 8 respiratory respiratory JJ cord-295206-vetdsk48 19 9 tract tract NN cord-295206-vetdsk48 19 10 infection infection NN cord-295206-vetdsk48 19 11 Gonzales Gonzales NNP cord-295206-vetdsk48 19 12 and and CC cord-295206-vetdsk48 19 13 Sande Sande NNP cord-295206-vetdsk48 19 14 ( ( -LRB- cord-295206-vetdsk48 19 15 2000 2000 CD cord-295206-vetdsk48 19 16 ) ) -RRB- cord-295206-vetdsk48 19 17 . . . cord-295206-vetdsk48 20 1 Although although IN cord-295206-vetdsk48 20 2 an an DT cord-295206-vetdsk48 20 3 etiology etiology NN cord-295206-vetdsk48 20 4 is be VBZ cord-295206-vetdsk48 20 5 formally formally RB cord-295206-vetdsk48 20 6 identified identify VBN cord-295206-vetdsk48 20 7 in in IN cord-295206-vetdsk48 20 8 only only RB cord-295206-vetdsk48 20 9 a a DT cord-295206-vetdsk48 20 10 small small JJ cord-295206-vetdsk48 20 11 percentage percentage NN cord-295206-vetdsk48 20 12 of of IN cord-295206-vetdsk48 20 13 clinical clinical JJ cord-295206-vetdsk48 20 14 cases case NNS cord-295206-vetdsk48 20 15 , , , cord-295206-vetdsk48 20 16 the the DT cord-295206-vetdsk48 20 17 identity identity NN cord-295206-vetdsk48 20 18 of of IN cord-295206-vetdsk48 20 19 the the DT cord-295206-vetdsk48 20 20 disease disease NN cord-295206-vetdsk48 20 21 - - HYPH cord-295206-vetdsk48 20 22 producing produce VBG cord-295206-vetdsk48 20 23 organism organism NN cord-295206-vetdsk48 20 24 may may MD cord-295206-vetdsk48 20 25 be be VB cord-295206-vetdsk48 20 26 used use VBN cord-295206-vetdsk48 20 27 to to TO cord-295206-vetdsk48 20 28 classify classify VB cord-295206-vetdsk48 20 29 acute acute JJ cord-295206-vetdsk48 20 30 bronchitis bronchitis NN cord-295206-vetdsk48 20 31 . . . cord-295206-vetdsk48 21 1 Chronic chronic JJ cord-295206-vetdsk48 21 2 bronchitis bronchitis NN cord-295206-vetdsk48 21 3 is be VBZ cord-295206-vetdsk48 21 4 the the DT cord-295206-vetdsk48 21 5 most most RBS cord-295206-vetdsk48 21 6 common common JJ cord-295206-vetdsk48 21 7 form form NN cord-295206-vetdsk48 21 8 of of IN cord-295206-vetdsk48 21 9 chronic chronic JJ cord-295206-vetdsk48 21 10 obstructive obstructive JJ cord-295206-vetdsk48 21 11 pulmonary pulmonary JJ cord-295206-vetdsk48 21 12 disease disease NN cord-295206-vetdsk48 21 13 ( ( -LRB- cord-295206-vetdsk48 21 14 COPD COPD NNP cord-295206-vetdsk48 21 15 ) ) -RRB- cord-295206-vetdsk48 21 16 , , , cord-295206-vetdsk48 21 17 a a DT cord-295206-vetdsk48 21 18 group group NN cord-295206-vetdsk48 21 19 of of IN cord-295206-vetdsk48 21 20 conditions condition NNS cord-295206-vetdsk48 21 21 involving involve VBG cord-295206-vetdsk48 21 22 airway airway JJ cord-295206-vetdsk48 21 23 obstruction obstruction NN cord-295206-vetdsk48 21 24 , , , cord-295206-vetdsk48 21 25 decreased decrease VBD cord-295206-vetdsk48 21 26 maximal maximal JJ cord-295206-vetdsk48 21 27 expiratory expiratory JJ cord-295206-vetdsk48 21 28 airflow airflow NN cord-295206-vetdsk48 21 29 , , , cord-295206-vetdsk48 21 30 and and CC cord-295206-vetdsk48 21 31 breathing breathing NN cord-295206-vetdsk48 21 32 - - HYPH cord-295206-vetdsk48 21 33 related relate VBN cord-295206-vetdsk48 21 34 symptoms symptom NNS cord-295206-vetdsk48 21 35 . . . cord-295206-vetdsk48 22 1 Emphysema emphysema NN cord-295206-vetdsk48 22 2 , , , cord-295206-vetdsk48 22 3 or or CC cord-295206-vetdsk48 22 4 destruction destruction NN cord-295206-vetdsk48 22 5 of of IN cord-295206-vetdsk48 22 6 the the DT cord-295206-vetdsk48 22 7 alveoli alveolus NNS cord-295206-vetdsk48 22 8 , , , cord-295206-vetdsk48 22 9 is be VBZ cord-295206-vetdsk48 22 10 the the DT cord-295206-vetdsk48 22 11 other other JJ cord-295206-vetdsk48 22 12 major major JJ cord-295206-vetdsk48 22 13 manifestation manifestation NN cord-295206-vetdsk48 22 14 of of IN cord-295206-vetdsk48 22 15 COPD COPD NNP cord-295206-vetdsk48 22 16 Chitkara Chitkara NNP cord-295206-vetdsk48 22 17 and and CC cord-295206-vetdsk48 22 18 Sarinas Sarinas NNP cord-295206-vetdsk48 22 19 ( ( -LRB- cord-295206-vetdsk48 22 20 2002 2002 CD cord-295206-vetdsk48 22 21 ) ) -RRB- cord-295206-vetdsk48 22 22 . . . cord-295206-vetdsk48 23 1 Nonremittant nonremittant JJ cord-295206-vetdsk48 23 2 asthma asthma NN cord-295206-vetdsk48 23 3 , , , cord-295206-vetdsk48 23 4 involving involve VBG cord-295206-vetdsk48 23 5 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 23 6 that that WDT cord-295206-vetdsk48 23 7 is be VBZ cord-295206-vetdsk48 23 8 irreversible irreversible JJ cord-295206-vetdsk48 23 9 or or CC cord-295206-vetdsk48 23 10 only only RB cord-295206-vetdsk48 23 11 partially partially RB cord-295206-vetdsk48 23 12 reversible reversible JJ cord-295206-vetdsk48 23 13 , , , cord-295206-vetdsk48 23 14 may may MD cord-295206-vetdsk48 23 15 also also RB cord-295206-vetdsk48 23 16 be be VB cord-295206-vetdsk48 23 17 classified classify VBN cord-295206-vetdsk48 23 18 as as IN cord-295206-vetdsk48 23 19 COP COP NNP cord-295206-vetdsk48 23 20 D. D. NNP cord-295206-vetdsk48 24 1 It -PRON- PRP cord-295206-vetdsk48 24 2 is be VBZ cord-295206-vetdsk48 24 3 not not RB cord-295206-vetdsk48 24 4 unusual unusual JJ cord-295206-vetdsk48 24 5 for for IN cord-295206-vetdsk48 24 6 individuals individual NNS cord-295206-vetdsk48 24 7 to to TO cord-295206-vetdsk48 24 8 experience experience VB cord-295206-vetdsk48 24 9 combined combine VBN cord-295206-vetdsk48 24 10 forms form NNS cord-295206-vetdsk48 24 11 of of IN cord-295206-vetdsk48 24 12 COPD COPD NNP cord-295206-vetdsk48 24 13 involving involve VBG cord-295206-vetdsk48 24 14 sputum sputum NN cord-295206-vetdsk48 24 15 production production NN cord-295206-vetdsk48 24 16 , , , cord-295206-vetdsk48 24 17 alveolar alveolar JJ cord-295206-vetdsk48 24 18 destruction destruction NN cord-295206-vetdsk48 24 19 , , , cord-295206-vetdsk48 24 20 and and CC cord-295206-vetdsk48 24 21 bronchospasm bronchospasm NN cord-295206-vetdsk48 24 22 . . . cord-295206-vetdsk48 25 1 COPD COPD NNP cord-295206-vetdsk48 25 2 can can MD cord-295206-vetdsk48 25 3 be be VB cord-295206-vetdsk48 25 4 classified classify VBN cord-295206-vetdsk48 25 5 on on IN cord-295206-vetdsk48 25 6 the the DT cord-295206-vetdsk48 25 7 basis basis NN cord-295206-vetdsk48 25 8 of of IN cord-295206-vetdsk48 25 9 severity severity NN cord-295206-vetdsk48 25 10 Pauwels Pauwels NNP cord-295206-vetdsk48 25 11 et et FW cord-295206-vetdsk48 25 12 al al NNP cord-295206-vetdsk48 25 13 ( ( -LRB- cord-295206-vetdsk48 25 14 2001 2001 CD cord-295206-vetdsk48 25 15 ) ) -RRB- cord-295206-vetdsk48 25 16 . . . cord-295206-vetdsk48 26 1 Stage stage NN cord-295206-vetdsk48 26 2 0 0 NFP cord-295206-vetdsk48 26 3 ( ( -LRB- cord-295206-vetdsk48 26 4 at at IN cord-295206-vetdsk48 26 5 risk risk NN cord-295206-vetdsk48 26 6 ) ) -RRB- cord-295206-vetdsk48 26 7 is be VBZ cord-295206-vetdsk48 26 8 characterized characterize VBN cord-295206-vetdsk48 26 9 by by IN cord-295206-vetdsk48 26 10 normal normal JJ cord-295206-vetdsk48 26 11 spirometric spirometric JJ cord-295206-vetdsk48 26 12 readings reading NNS cord-295206-vetdsk48 26 13 and and CC cord-295206-vetdsk48 26 14 the the DT cord-295206-vetdsk48 26 15 presence presence NN cord-295206-vetdsk48 26 16 of of IN cord-295206-vetdsk48 26 17 chronic chronic JJ cord-295206-vetdsk48 26 18 cough cough NN cord-295206-vetdsk48 26 19 and/or and/or CC cord-295206-vetdsk48 26 20 sputum sputum NN cord-295206-vetdsk48 26 21 production production NN cord-295206-vetdsk48 26 22 . . . cord-295206-vetdsk48 27 1 Stages stage NNS cord-295206-vetdsk48 28 1 I -PRON- PRP cord-295206-vetdsk48 28 2 , , , cord-295206-vetdsk48 28 3 II II NNP cord-295206-vetdsk48 28 4 , , , cord-295206-vetdsk48 28 5 or or CC cord-295206-vetdsk48 28 6 III III NNP cord-295206-vetdsk48 28 7 COPD COPD NNP cord-295206-vetdsk48 28 8 is be VBZ cord-295206-vetdsk48 28 9 present present JJ cord-295206-vetdsk48 28 10 if if IN cord-295206-vetdsk48 28 11 the the DT cord-295206-vetdsk48 28 12 forced force VBN cord-295206-vetdsk48 28 13 expiratory expiratory JJ cord-295206-vetdsk48 28 14 volume volume NN cord-295206-vetdsk48 28 15 in in IN cord-295206-vetdsk48 28 16 1 1 CD cord-295206-vetdsk48 28 17 second second NN cord-295206-vetdsk48 28 18 divided divide VBN cord-295206-vetdsk48 28 19 by by IN cord-295206-vetdsk48 28 20 the the DT cord-295206-vetdsk48 28 21 forced force VBN cord-295206-vetdsk48 28 22 vital vital JJ cord-295206-vetdsk48 28 23 capacity capacity NN cord-295206-vetdsk48 28 24 ( ( -LRB- cord-295206-vetdsk48 28 25 FEV FEV NNP cord-295206-vetdsk48 28 26 1 1 CD cord-295206-vetdsk48 28 27 /FVC /FVC . cord-295206-vetdsk48 28 28 ) ) -RRB- cord-295206-vetdsk48 28 29 is be VBZ cord-295206-vetdsk48 28 30 less less JJR cord-295206-vetdsk48 28 31 than than IN cord-295206-vetdsk48 28 32 70 70 CD cord-295206-vetdsk48 28 33 % % NN cord-295206-vetdsk48 28 34 . . . cord-295206-vetdsk48 29 1 Chronic Chronic NNP cord-295206-vetdsk48 29 2 Both both DT cord-295206-vetdsk48 29 3 acute acute JJ cord-295206-vetdsk48 29 4 and and CC cord-295206-vetdsk48 29 5 chronic chronic JJ cord-295206-vetdsk48 29 6 bronchitis bronchitis NN cord-295206-vetdsk48 29 7 give give VBP cord-295206-vetdsk48 29 8 rise rise NN cord-295206-vetdsk48 29 9 to to IN cord-295206-vetdsk48 29 10 a a DT cord-295206-vetdsk48 29 11 persistent persistent JJ cord-295206-vetdsk48 29 12 , , , cord-295206-vetdsk48 29 13 sputum sputum NN cord-295206-vetdsk48 29 14 - - HYPH cord-295206-vetdsk48 29 15 producing produce VBG cord-295206-vetdsk48 29 16 cough cough NN cord-295206-vetdsk48 29 17 . . . cord-295206-vetdsk48 30 1 Bronchial bronchial JJ cord-295206-vetdsk48 30 2 hyperresponsiveness hyperresponsiveness NN cord-295206-vetdsk48 30 3 , , , cord-295206-vetdsk48 30 4 wheezing wheeze VBG cord-295206-vetdsk48 30 5 , , , cord-295206-vetdsk48 30 6 and and CC cord-295206-vetdsk48 30 7 difficulty difficulty NN cord-295206-vetdsk48 30 8 breathing breathing NN cord-295206-vetdsk48 30 9 ( ( -LRB- cord-295206-vetdsk48 30 10 dyspnea dyspnea NN cord-295206-vetdsk48 30 11 ) ) -RRB- cord-295206-vetdsk48 30 12 may may MD cord-295206-vetdsk48 30 13 occur occur VB cord-295206-vetdsk48 30 14 , , , cord-295206-vetdsk48 30 15 and and CC cord-295206-vetdsk48 30 16 difficulty difficulty NN cord-295206-vetdsk48 30 17 breathing breathe VBG cord-295206-vetdsk48 30 18 upon upon IN cord-295206-vetdsk48 30 19 exercise exercise NN cord-295206-vetdsk48 30 20 ( ( -LRB- cord-295206-vetdsk48 30 21 exertional exertional JJ cord-295206-vetdsk48 30 22 dyspnea dyspnea NN cord-295206-vetdsk48 30 23 ) ) -RRB- cord-295206-vetdsk48 30 24 is be VBZ cord-295206-vetdsk48 30 25 fairly fairly RB cord-295206-vetdsk48 30 26 common common JJ cord-295206-vetdsk48 30 27 . . . cord-295206-vetdsk48 31 1 In in IN cord-295206-vetdsk48 31 2 most most JJS cord-295206-vetdsk48 31 3 cases case NNS cord-295206-vetdsk48 31 4 of of IN cord-295206-vetdsk48 31 5 acute acute JJ cord-295206-vetdsk48 31 6 bronchitis bronchitis NN cord-295206-vetdsk48 31 7 , , , cord-295206-vetdsk48 31 8 the the DT cord-295206-vetdsk48 31 9 symptoms symptom NNS cord-295206-vetdsk48 31 10 of of IN cord-295206-vetdsk48 31 11 cough cough NN cord-295206-vetdsk48 31 12 and and CC cord-295206-vetdsk48 31 13 sputum sputum NN cord-295206-vetdsk48 31 14 production production NN cord-295206-vetdsk48 31 15 last last RB cord-295206-vetdsk48 31 16 for for IN cord-295206-vetdsk48 31 17 1 1 CD cord-295206-vetdsk48 31 18 to to TO cord-295206-vetdsk48 31 19 3 3 CD cord-295206-vetdsk48 31 20 weeks week NNS cord-295206-vetdsk48 32 1 Gonzales Gonzales NNP cord-295206-vetdsk48 32 2 and and CC cord-295206-vetdsk48 32 3 Sande Sande NNP cord-295206-vetdsk48 32 4 ( ( -LRB- cord-295206-vetdsk48 32 5 2000 2000 CD cord-295206-vetdsk48 32 6 ) ) -RRB- cord-295206-vetdsk48 32 7 . . . cord-295206-vetdsk48 33 1 Infections infection NNS cord-295206-vetdsk48 33 2 such such JJ cord-295206-vetdsk48 33 3 as as IN cord-295206-vetdsk48 33 4 otitis otitis NN cord-295206-vetdsk48 33 5 media medium NNS cord-295206-vetdsk48 33 6 , , , cord-295206-vetdsk48 33 7 sinusitis sinusitis NN cord-295206-vetdsk48 33 8 , , , cord-295206-vetdsk48 33 9 and and CC cord-295206-vetdsk48 33 10 , , , cord-295206-vetdsk48 33 11 more more RBR cord-295206-vetdsk48 33 12 rarely rarely RB cord-295206-vetdsk48 33 13 , , , cord-295206-vetdsk48 33 14 pneumonia pneumonia NN cord-295206-vetdsk48 33 15 may may MD cord-295206-vetdsk48 33 16 result result VB cord-295206-vetdsk48 33 17 from from IN cord-295206-vetdsk48 33 18 either either CC cord-295206-vetdsk48 33 19 the the DT cord-295206-vetdsk48 33 20 primary primary JJ cord-295206-vetdsk48 33 21 viral viral JJ cord-295206-vetdsk48 33 22 infection infection NN cord-295206-vetdsk48 33 23 or or CC cord-295206-vetdsk48 33 24 a a DT cord-295206-vetdsk48 33 25 secondary secondary JJ cord-295206-vetdsk48 33 26 bacterial bacterial JJ cord-295206-vetdsk48 33 27 infection infection NN cord-295206-vetdsk48 33 28 . . . cord-295206-vetdsk48 34 1 Acute acute JJ cord-295206-vetdsk48 34 2 bronchitis bronchitis NN cord-295206-vetdsk48 34 3 resulting result VBG cord-295206-vetdsk48 34 4 from from IN cord-295206-vetdsk48 34 5 influenza influenza NN cord-295206-vetdsk48 34 6 may may MD cord-295206-vetdsk48 34 7 additionally additionally RB cord-295206-vetdsk48 34 8 produce produce VB cord-295206-vetdsk48 34 9 more more JJR cord-295206-vetdsk48 34 10 rare rare JJ cord-295206-vetdsk48 34 11 complications complication NNS cord-295206-vetdsk48 34 12 of of IN cord-295206-vetdsk48 34 13 muscular muscular JJ cord-295206-vetdsk48 34 14 inflammation inflammation NN cord-295206-vetdsk48 34 15 ( ( -LRB- cord-295206-vetdsk48 34 16 myositis myositis NN cord-295206-vetdsk48 34 17 ) ) -RRB- cord-295206-vetdsk48 34 18 and and CC cord-295206-vetdsk48 34 19 muscle muscle NN cord-295206-vetdsk48 34 20 cell cell NN cord-295206-vetdsk48 34 21 lysis lysis NN cord-295206-vetdsk48 34 22 leading lead VBG cord-295206-vetdsk48 34 23 to to IN cord-295206-vetdsk48 34 24 potentially potentially RB cord-295206-vetdsk48 34 25 fatal fatal JJ cord-295206-vetdsk48 34 26 renal renal JJ cord-295206-vetdsk48 34 27 damage damage NN cord-295206-vetdsk48 34 28 ( ( -LRB- cord-295206-vetdsk48 34 29 rhabdomyolyisis rhabdomyolyisis NNP cord-295206-vetdsk48 34 30 ) ) -RRB- cord-295206-vetdsk48 34 31 . . . cord-295206-vetdsk48 35 1 Additional additional JJ cord-295206-vetdsk48 35 2 consequences consequence NNS cord-295206-vetdsk48 35 3 of of IN cord-295206-vetdsk48 35 4 acute acute JJ cord-295206-vetdsk48 35 5 bronchitis bronchitis NN cord-295206-vetdsk48 35 6 are be VBP cord-295206-vetdsk48 35 7 seen see VBN cord-295206-vetdsk48 35 8 in in IN cord-295206-vetdsk48 35 9 children child NNS cord-295206-vetdsk48 35 10 . . . cord-295206-vetdsk48 36 1 Reye Reye NNP cord-295206-vetdsk48 36 2 syndrome syndrome NN cord-295206-vetdsk48 36 3 may may MD cord-295206-vetdsk48 36 4 occur occur VB cord-295206-vetdsk48 36 5 in in IN cord-295206-vetdsk48 36 6 children child NNS cord-295206-vetdsk48 36 7 with with IN cord-295206-vetdsk48 36 8 influenza influenza NN cord-295206-vetdsk48 36 9 , , , cord-295206-vetdsk48 36 10 particularly particularly RB cord-295206-vetdsk48 36 11 if if IN cord-295206-vetdsk48 36 12 they -PRON- PRP cord-295206-vetdsk48 36 13 are be VBP cord-295206-vetdsk48 36 14 treated treat VBN cord-295206-vetdsk48 36 15 with with IN cord-295206-vetdsk48 36 16 aspirin aspirin NN cord-295206-vetdsk48 36 17 . . . cord-295206-vetdsk48 37 1 Viral viral JJ cord-295206-vetdsk48 37 2 lower low JJR cord-295206-vetdsk48 37 3 respiratory respiratory JJ cord-295206-vetdsk48 37 4 infection infection NN cord-295206-vetdsk48 37 5 in in IN cord-295206-vetdsk48 37 6 early early JJ cord-295206-vetdsk48 37 7 life life NN cord-295206-vetdsk48 37 8 has have VBZ cord-295206-vetdsk48 37 9 been be VBN cord-295206-vetdsk48 37 10 associated associate VBN cord-295206-vetdsk48 37 11 with with IN cord-295206-vetdsk48 37 12 the the DT cord-295206-vetdsk48 37 13 later later JJ cord-295206-vetdsk48 37 14 development development NN cord-295206-vetdsk48 37 15 of of IN cord-295206-vetdsk48 37 16 asthma asthma NN cord-295206-vetdsk48 37 17 Gern Gern NNP cord-295206-vetdsk48 37 18 ( ( -LRB- cord-295206-vetdsk48 37 19 2000 2000 CD cord-295206-vetdsk48 37 20 ) ) -RRB- cord-295206-vetdsk48 37 21 . . . cord-295206-vetdsk48 38 1 In in IN cord-295206-vetdsk48 38 2 contrast contrast NN cord-295206-vetdsk48 38 3 to to IN cord-295206-vetdsk48 38 4 acute acute JJ cord-295206-vetdsk48 38 5 bronchitis bronchitis NN cord-295206-vetdsk48 38 6 , , , cord-295206-vetdsk48 38 7 which which WDT cord-295206-vetdsk48 38 8 resolves resolve VBZ cord-295206-vetdsk48 38 9 following follow VBG cord-295206-vetdsk48 38 10 the the DT cord-295206-vetdsk48 38 11 termination termination NN cord-295206-vetdsk48 38 12 of of IN cord-295206-vetdsk48 38 13 the the DT cord-295206-vetdsk48 38 14 causative causative JJ cord-295206-vetdsk48 38 15 infection infection NN cord-295206-vetdsk48 38 16 , , , cord-295206-vetdsk48 38 17 chronic chronic JJ cord-295206-vetdsk48 38 18 bronchitis bronchitis NN cord-295206-vetdsk48 38 19 generally generally RB cord-295206-vetdsk48 38 20 worsens worsen VBZ cord-295206-vetdsk48 38 21 with with IN cord-295206-vetdsk48 38 22 time time NN cord-295206-vetdsk48 38 23 , , , cord-295206-vetdsk48 38 24 even even RB cord-295206-vetdsk48 38 25 with with IN cord-295206-vetdsk48 38 26 optimal optimal JJ cord-295206-vetdsk48 38 27 treatment treatment NN cord-295206-vetdsk48 38 28 Chitkara Chitkara NNP cord-295206-vetdsk48 38 29 and and CC cord-295206-vetdsk48 38 30 Sarinas Sarinas NNP cord-295206-vetdsk48 38 31 ( ( -LRB- cord-295206-vetdsk48 38 32 2002 2002 CD cord-295206-vetdsk48 38 33 ) ) -RRB- cord-295206-vetdsk48 38 34 . . . cord-295206-vetdsk48 39 1 Cessation cessation NN cord-295206-vetdsk48 39 2 of of IN cord-295206-vetdsk48 39 3 exposure exposure NN cord-295206-vetdsk48 39 4 to to IN cord-295206-vetdsk48 39 5 a a DT cord-295206-vetdsk48 39 6 triggering trigger VBG cord-295206-vetdsk48 39 7 stimulus stimulus NN cord-295206-vetdsk48 39 8 , , , cord-295206-vetdsk48 39 9 such such JJ cord-295206-vetdsk48 39 10 as as IN cord-295206-vetdsk48 39 11 tobacco tobacco NN cord-295206-vetdsk48 39 12 smoke smoke NN cord-295206-vetdsk48 39 13 , , , cord-295206-vetdsk48 39 14 is be VBZ cord-295206-vetdsk48 39 15 the the DT cord-295206-vetdsk48 39 16 only only RB cord-295206-vetdsk48 39 17 currently currently RB cord-295206-vetdsk48 39 18 available available JJ cord-295206-vetdsk48 39 19 therapeutic therapeutic JJ cord-295206-vetdsk48 39 20 management management NN cord-295206-vetdsk48 39 21 that that WDT cord-295206-vetdsk48 39 22 can can MD cord-295206-vetdsk48 39 23 slow slow VB cord-295206-vetdsk48 39 24 the the DT cord-295206-vetdsk48 39 25 progression progression NN cord-295206-vetdsk48 39 26 of of IN cord-295206-vetdsk48 39 27 chronic chronic JJ cord-295206-vetdsk48 39 28 bronchitis bronchitis NN cord-295206-vetdsk48 39 29 . . . cord-295206-vetdsk48 40 1 Usually usually RB cord-295206-vetdsk48 40 2 , , , cord-295206-vetdsk48 40 3 by by IN cord-295206-vetdsk48 40 4 the the DT cord-295206-vetdsk48 40 5 time time NN cord-295206-vetdsk48 40 6 treatment treatment NN cord-295206-vetdsk48 40 7 is be VBZ cord-295206-vetdsk48 40 8 sought seek VBN cord-295206-vetdsk48 40 9 , , , cord-295206-vetdsk48 40 10 there there EX cord-295206-vetdsk48 40 11 is be VBZ cord-295206-vetdsk48 40 12 irreversible irreversible JJ cord-295206-vetdsk48 40 13 damage damage NN cord-295206-vetdsk48 40 14 to to IN cord-295206-vetdsk48 40 15 the the DT cord-295206-vetdsk48 40 16 lungs lung NNS cord-295206-vetdsk48 40 17 . . . cord-295206-vetdsk48 41 1 Progression progression NN cord-295206-vetdsk48 41 2 of of IN cord-295206-vetdsk48 41 3 chronic chronic JJ cord-295206-vetdsk48 41 4 bronchitis bronchitis NN cord-295206-vetdsk48 41 5 leads lead VBZ cord-295206-vetdsk48 41 6 to to IN cord-295206-vetdsk48 41 7 shortness shortness NN cord-295206-vetdsk48 41 8 of of IN cord-295206-vetdsk48 41 9 breath breath NN cord-295206-vetdsk48 41 10 , , , cord-295206-vetdsk48 41 11 initially initially RB cord-295206-vetdsk48 41 12 manifesting manifest VBG cord-295206-vetdsk48 41 13 only only RB cord-295206-vetdsk48 41 14 during during IN cord-295206-vetdsk48 41 15 exercise exercise NN cord-295206-vetdsk48 41 16 but but CC cord-295206-vetdsk48 41 17 also also RB cord-295206-vetdsk48 41 18 occurring occur VBG cord-295206-vetdsk48 41 19 at at IN cord-295206-vetdsk48 41 20 rest rest NN cord-295206-vetdsk48 41 21 as as IN cord-295206-vetdsk48 41 22 the the DT cord-295206-vetdsk48 41 23 disease disease NN cord-295206-vetdsk48 41 24 worsens worsen VBZ cord-295206-vetdsk48 41 25 . . . cord-295206-vetdsk48 42 1 Increasing increase VBG cord-295206-vetdsk48 42 2 pulmonary pulmonary JJ cord-295206-vetdsk48 42 3 dysfunction dysfunction NN cord-295206-vetdsk48 42 4 can can MD cord-295206-vetdsk48 42 5 result result VB cord-295206-vetdsk48 42 6 in in IN cord-295206-vetdsk48 42 7 pulmonary pulmonary JJ cord-295206-vetdsk48 42 8 hypertension hypertension NN cord-295206-vetdsk48 42 9 , , , cord-295206-vetdsk48 42 10 right right JJ cord-295206-vetdsk48 42 11 ventricular ventricular JJ cord-295206-vetdsk48 42 12 enlargement enlargement NN cord-295206-vetdsk48 42 13 , , , cord-295206-vetdsk48 42 14 and and CC cord-295206-vetdsk48 42 15 right right RB cord-295206-vetdsk48 42 16 - - HYPH cord-295206-vetdsk48 42 17 sided sided JJ cord-295206-vetdsk48 42 18 heart heart NN cord-295206-vetdsk48 42 19 failure failure NN cord-295206-vetdsk48 42 20 ( ( -LRB- cord-295206-vetdsk48 42 21 cor cor NNP cord-295206-vetdsk48 42 22 pulmonale pulmonale NNP cord-295206-vetdsk48 42 23 ) ) -RRB- cord-295206-vetdsk48 42 24 . . . cord-295206-vetdsk48 43 1 Signs sign NNS cord-295206-vetdsk48 43 2 of of IN cord-295206-vetdsk48 43 3 cor cor NN cord-295206-vetdsk48 43 4 pulmonale pulmonale NN cord-295206-vetdsk48 43 5 include include VBP cord-295206-vetdsk48 43 6 peripheral peripheral JJ cord-295206-vetdsk48 43 7 edema edema NN cord-295206-vetdsk48 43 8 , , , cord-295206-vetdsk48 43 9 enlargement enlargement NN cord-295206-vetdsk48 43 10 of of IN cord-295206-vetdsk48 43 11 the the DT cord-295206-vetdsk48 43 12 liver liver NN cord-295206-vetdsk48 43 13 and and CC cord-295206-vetdsk48 43 14 other other JJ cord-295206-vetdsk48 43 15 internal internal JJ cord-295206-vetdsk48 43 16 organs organ NNS cord-295206-vetdsk48 43 17 , , , cord-295206-vetdsk48 43 18 and and CC cord-295206-vetdsk48 43 19 increased increase VBN cord-295206-vetdsk48 43 20 breathing breathing NN cord-295206-vetdsk48 43 21 difficulty difficulty NN cord-295206-vetdsk48 43 22 . . . cord-295206-vetdsk48 44 1 Weight weight NN cord-295206-vetdsk48 44 2 loss loss NN cord-295206-vetdsk48 44 3 may may MD cord-295206-vetdsk48 44 4 occur occur VB cord-295206-vetdsk48 44 5 , , , cord-295206-vetdsk48 44 6 and and CC cord-295206-vetdsk48 44 7 muscle muscle NN cord-295206-vetdsk48 44 8 wasting wasting NN cord-295206-vetdsk48 44 9 can can MD cord-295206-vetdsk48 44 10 contribute contribute VB cord-295206-vetdsk48 44 11 to to IN cord-295206-vetdsk48 44 12 the the DT cord-295206-vetdsk48 44 13 development development NN cord-295206-vetdsk48 44 14 of of IN cord-295206-vetdsk48 44 15 exercise exercise NN cord-295206-vetdsk48 44 16 intolerance intolerance NN cord-295206-vetdsk48 44 17 . . . cord-295206-vetdsk48 45 1 An an DT cord-295206-vetdsk48 45 2 individual individual NN cord-295206-vetdsk48 45 3 affected affect VBN cord-295206-vetdsk48 45 4 with with IN cord-295206-vetdsk48 45 5 chronic chronic JJ cord-295206-vetdsk48 45 6 bronchitis bronchitis NN cord-295206-vetdsk48 45 7 is be VBZ cord-295206-vetdsk48 45 8 susceptible susceptible JJ cord-295206-vetdsk48 45 9 to to IN cord-295206-vetdsk48 45 10 repeated repeat VBN cord-295206-vetdsk48 45 11 episodes episode NNS cord-295206-vetdsk48 45 12 in in IN cord-295206-vetdsk48 45 13 which which WDT cord-295206-vetdsk48 45 14 the the DT cord-295206-vetdsk48 45 15 symptoms symptom NNS cord-295206-vetdsk48 45 16 of of IN cord-295206-vetdsk48 45 17 cough cough NN cord-295206-vetdsk48 45 18 , , , cord-295206-vetdsk48 45 19 sputum sputum NN cord-295206-vetdsk48 45 20 production production NN cord-295206-vetdsk48 45 21 , , , cord-295206-vetdsk48 45 22 and and CC cord-295206-vetdsk48 45 23 dyspnea dyspnea NN cord-295206-vetdsk48 45 24 worsen worsen VBP cord-295206-vetdsk48 45 25 McCrory McCrory NNP cord-295206-vetdsk48 45 26 et et NNP cord-295206-vetdsk48 45 27 al al NNP cord-295206-vetdsk48 45 28 ( ( -LRB- cord-295206-vetdsk48 45 29 2001 2001 CD cord-295206-vetdsk48 45 30 ) ) -RRB- cord-295206-vetdsk48 45 31 . . . cord-295206-vetdsk48 46 1 These these DT cord-295206-vetdsk48 46 2 episodes episode NNS cord-295206-vetdsk48 46 3 , , , cord-295206-vetdsk48 46 4 termed term VBD cord-295206-vetdsk48 46 5 acute acute JJ cord-295206-vetdsk48 46 6 exacerbations exacerbation NNS cord-295206-vetdsk48 46 7 of of IN cord-295206-vetdsk48 46 8 chronic chronic JJ cord-295206-vetdsk48 46 9 bronchitis bronchitis NN cord-295206-vetdsk48 46 10 , , , cord-295206-vetdsk48 46 11 may may MD cord-295206-vetdsk48 46 12 result result VB cord-295206-vetdsk48 46 13 from from IN cord-295206-vetdsk48 46 14 viral viral JJ cord-295206-vetdsk48 46 15 or or CC cord-295206-vetdsk48 46 16 , , , cord-295206-vetdsk48 46 17 more more RBR cord-295206-vetdsk48 46 18 rarely rarely RB cord-295206-vetdsk48 46 19 , , , cord-295206-vetdsk48 46 20 bacterial bacterial JJ cord-295206-vetdsk48 46 21 infection infection NN cord-295206-vetdsk48 46 22 . . . cord-295206-vetdsk48 47 1 Environmental environmental JJ cord-295206-vetdsk48 47 2 exposure exposure NN cord-295206-vetdsk48 47 3 to to IN cord-295206-vetdsk48 47 4 tobacco tobacco NN cord-295206-vetdsk48 47 5 smoke smoke NN cord-295206-vetdsk48 47 6 , , , cord-295206-vetdsk48 47 7 air air NN cord-295206-vetdsk48 47 8 pollutants pollutant NNS cord-295206-vetdsk48 47 9 , , , cord-295206-vetdsk48 47 10 or or CC cord-295206-vetdsk48 47 11 allergens allergen NNS cord-295206-vetdsk48 47 12 may may MD cord-295206-vetdsk48 47 13 also also RB cord-295206-vetdsk48 47 14 produce produce VB cord-295206-vetdsk48 47 15 acute acute JJ cord-295206-vetdsk48 47 16 exacerbations exacerbation NNS cord-295206-vetdsk48 47 17 of of IN cord-295206-vetdsk48 47 18 chronic chronic JJ cord-295206-vetdsk48 47 19 bronchitis bronchitis NN cord-295206-vetdsk48 47 20 . . . cord-295206-vetdsk48 48 1 The the DT cord-295206-vetdsk48 48 2 cause cause NN cord-295206-vetdsk48 48 3 of of IN cord-295206-vetdsk48 48 4 approximately approximately RB cord-295206-vetdsk48 48 5 one one CD cord-295206-vetdsk48 48 6 - - HYPH cord-295206-vetdsk48 48 7 third third NN cord-295206-vetdsk48 48 8 of of IN cord-295206-vetdsk48 48 9 acute acute JJ cord-295206-vetdsk48 48 10 exacerbations exacerbation NNS cord-295206-vetdsk48 48 11 is be VBZ cord-295206-vetdsk48 48 12 unknown unknown JJ cord-295206-vetdsk48 48 13 . . . cord-295206-vetdsk48 49 1 immunocompromised immunocompromised JJ cord-295206-vetdsk48 49 2 individuals individual NNS cord-295206-vetdsk48 49 3 , , , cord-295206-vetdsk48 49 4 persons person NNS cord-295206-vetdsk48 49 5 with with IN cord-295206-vetdsk48 49 6 comorbid comorbid NN cord-295206-vetdsk48 49 7 conditions condition NNS cord-295206-vetdsk48 49 8 , , , cord-295206-vetdsk48 49 9 such such JJ cord-295206-vetdsk48 49 10 as as IN cord-295206-vetdsk48 49 11 diabetes diabetes NN cord-295206-vetdsk48 49 12 , , , cord-295206-vetdsk48 49 13 cardiovascular cardiovascular JJ cord-295206-vetdsk48 49 14 disease disease NN cord-295206-vetdsk48 49 15 , , , cord-295206-vetdsk48 49 16 pulmonary pulmonary JJ cord-295206-vetdsk48 49 17 disease disease NN cord-295206-vetdsk48 49 18 , , , cord-295206-vetdsk48 49 19 and and CC cord-295206-vetdsk48 49 20 alcoholics alcoholic NNS cord-295206-vetdsk48 49 21 Gonzales Gonzales NNP cord-295206-vetdsk48 49 22 and and CC cord-295206-vetdsk48 49 23 Sande Sande NNP cord-295206-vetdsk48 49 24 ( ( -LRB- cord-295206-vetdsk48 49 25 2000 2000 CD cord-295206-vetdsk48 49 26 ) ) -RRB- cord-295206-vetdsk48 49 27 . . . cord-295206-vetdsk48 50 1 These these DT cord-295206-vetdsk48 50 2 individuals individual NNS cord-295206-vetdsk48 50 3 are be VBP cord-295206-vetdsk48 50 4 also also RB cord-295206-vetdsk48 50 5 at at IN cord-295206-vetdsk48 50 6 higher high JJR cord-295206-vetdsk48 50 7 risk risk NN cord-295206-vetdsk48 50 8 of of IN cord-295206-vetdsk48 50 9 developing develop VBG cord-295206-vetdsk48 50 10 complications complication NNS cord-295206-vetdsk48 50 11 of of IN cord-295206-vetdsk48 50 12 acute acute JJ cord-295206-vetdsk48 50 13 bronchitis bronchitis NN cord-295206-vetdsk48 50 14 , , , cord-295206-vetdsk48 50 15 such such JJ cord-295206-vetdsk48 50 16 as as IN cord-295206-vetdsk48 50 17 pneumonia pneumonia NN cord-295206-vetdsk48 50 18 . . . cord-295206-vetdsk48 51 1 Chronic chronic JJ cord-295206-vetdsk48 51 2 bronchitis bronchitis NN cord-295206-vetdsk48 51 3 is be VBZ cord-295206-vetdsk48 51 4 the the DT cord-295206-vetdsk48 51 5 most most RBS cord-295206-vetdsk48 51 6 common common JJ cord-295206-vetdsk48 51 7 form form NN cord-295206-vetdsk48 51 8 of of IN cord-295206-vetdsk48 51 9 chronic chronic JJ cord-295206-vetdsk48 51 10 obstructive obstructive JJ cord-295206-vetdsk48 51 11 lung lung NN cord-295206-vetdsk48 51 12 disease disease NN cord-295206-vetdsk48 51 13 ( ( -LRB- cord-295206-vetdsk48 51 14 COPD COPD NNP cord-295206-vetdsk48 51 15 ) ) -RRB- cord-295206-vetdsk48 51 16 , , , cord-295206-vetdsk48 51 17 with with IN cord-295206-vetdsk48 51 18 emphysema emphysema NN cord-295206-vetdsk48 51 19 ( ( -LRB- cord-295206-vetdsk48 51 20 alveolar alveolar JJ cord-295206-vetdsk48 51 21 destruction destruction NN cord-295206-vetdsk48 51 22 ) ) -RRB- cord-295206-vetdsk48 51 23 being be VBG cord-295206-vetdsk48 51 24 the the DT cord-295206-vetdsk48 51 25 next next JJ cord-295206-vetdsk48 51 26 most most RBS cord-295206-vetdsk48 51 27 frequently frequently RB cord-295206-vetdsk48 51 28 observed observe VBD cord-295206-vetdsk48 51 29 manifestation manifestation NN cord-295206-vetdsk48 51 30 . . . cord-295206-vetdsk48 52 1 Nonremittant nonremittant JJ cord-295206-vetdsk48 52 2 asthma asthma NN cord-295206-vetdsk48 52 3 may may MD cord-295206-vetdsk48 52 4 also also RB cord-295206-vetdsk48 52 5 be be VB cord-295206-vetdsk48 52 6 classified classify VBN cord-295206-vetdsk48 52 7 as as IN cord-295206-vetdsk48 52 8 COP cop NN cord-295206-vetdsk48 52 9 D. D. NNP cord-295206-vetdsk48 52 10 It -PRON- PRP cord-295206-vetdsk48 52 11 is be VBZ cord-295206-vetdsk48 52 12 common common JJ cord-295206-vetdsk48 52 13 for for IN cord-295206-vetdsk48 52 14 individuals individual NNS cord-295206-vetdsk48 52 15 with with IN cord-295206-vetdsk48 52 16 COPD COPD NNP cord-295206-vetdsk48 52 17 to to TO cord-295206-vetdsk48 52 18 exhibit exhibit VB cord-295206-vetdsk48 52 19 characteristics characteristic NNS cord-295206-vetdsk48 52 20 of of IN cord-295206-vetdsk48 52 21 chronic chronic JJ cord-295206-vetdsk48 52 22 bronchitis bronchitis NN cord-295206-vetdsk48 52 23 , , , cord-295206-vetdsk48 52 24 emphysema emphysema NN cord-295206-vetdsk48 52 25 , , , cord-295206-vetdsk48 52 26 and/ and/ CD cord-295206-vetdsk48 52 27 or or CC cord-295206-vetdsk48 52 28 bronchospastic bronchospastic JJ cord-295206-vetdsk48 52 29 disease disease NN cord-295206-vetdsk48 52 30 . . . cord-295206-vetdsk48 53 1 Individuals individual NNS cord-295206-vetdsk48 53 2 with with IN cord-295206-vetdsk48 53 3 COPD COPD NNP cord-295206-vetdsk48 53 4 are be VBP cord-295206-vetdsk48 53 5 more more RBR cord-295206-vetdsk48 53 6 susceptible susceptible JJ cord-295206-vetdsk48 53 7 to to IN cord-295206-vetdsk48 53 8 lower low JJR cord-295206-vetdsk48 53 9 respiratory respiratory JJ cord-295206-vetdsk48 53 10 infections infection NNS cord-295206-vetdsk48 53 11 such such JJ cord-295206-vetdsk48 53 12 as as IN cord-295206-vetdsk48 53 13 acute acute JJ cord-295206-vetdsk48 53 14 bronchitis bronchitis NN cord-295206-vetdsk48 53 15 and and CC cord-295206-vetdsk48 53 16 pneumonia pneumonia NN cord-295206-vetdsk48 53 17 Ward Ward NNP cord-295206-vetdsk48 53 18 and and CC cord-295206-vetdsk48 53 19 Casaburi Casaburi NNP cord-295206-vetdsk48 53 20 ( ( -LRB- cord-295206-vetdsk48 53 21 2001 2001 CD cord-295206-vetdsk48 53 22 ) ) -RRB- cord-295206-vetdsk48 53 23 , , , cord-295206-vetdsk48 53 24 Chitkara Chitkara NNP cord-295206-vetdsk48 53 25 and and CC cord-295206-vetdsk48 53 26 Sarinas Sarinas NNP cord-295206-vetdsk48 53 27 ( ( -LRB- cord-295206-vetdsk48 53 28 2002 2002 CD cord-295206-vetdsk48 53 29 ) ) -RRB- cord-295206-vetdsk48 53 30 . . . cord-295206-vetdsk48 54 1 In in IN cord-295206-vetdsk48 54 2 more more RBR cord-295206-vetdsk48 54 3 advanced advanced JJ cord-295206-vetdsk48 54 4 disease disease NN cord-295206-vetdsk48 54 5 , , , cord-295206-vetdsk48 54 6 they -PRON- PRP cord-295206-vetdsk48 54 7 may may MD cord-295206-vetdsk48 54 8 develop develop VB cord-295206-vetdsk48 54 9 pulmonary pulmonary JJ cord-295206-vetdsk48 54 10 hypertension hypertension NN cord-295206-vetdsk48 54 11 , , , cord-295206-vetdsk48 54 12 resulting result VBG cord-295206-vetdsk48 54 13 in in IN cord-295206-vetdsk48 54 14 right right JJ cord-295206-vetdsk48 54 15 ventricular ventricular JJ cord-295206-vetdsk48 54 16 enlargement enlargement NN cord-295206-vetdsk48 54 17 and and CC cord-295206-vetdsk48 54 18 , , , cord-295206-vetdsk48 54 19 as as IN cord-295206-vetdsk48 54 20 the the DT cord-295206-vetdsk48 54 21 disease disease NN cord-295206-vetdsk48 54 22 progresses progress VBZ cord-295206-vetdsk48 54 23 , , , cord-295206-vetdsk48 54 24 right right JJ cord-295206-vetdsk48 54 25 - - HYPH cord-295206-vetdsk48 54 26 sided sided JJ cord-295206-vetdsk48 54 27 heart heart NN cord-295206-vetdsk48 54 28 failure failure NN cord-295206-vetdsk48 54 29 ( ( -LRB- cord-295206-vetdsk48 54 30 cor cor NNP cord-295206-vetdsk48 54 31 pulmonale pulmonale NNP cord-295206-vetdsk48 54 32 ) ) -RRB- cord-295206-vetdsk48 54 33 . . . cord-295206-vetdsk48 55 1 Acute acute JJ cord-295206-vetdsk48 55 2 bronchitis bronchitis NN cord-295206-vetdsk48 55 3 is be VBZ cord-295206-vetdsk48 55 4 usually usually RB cord-295206-vetdsk48 55 5 caused cause VBN cord-295206-vetdsk48 55 6 by by IN cord-295206-vetdsk48 55 7 viruses virus NNS cord-295206-vetdsk48 55 8 associated associate VBN cord-295206-vetdsk48 55 9 with with IN cord-295206-vetdsk48 55 10 lower low JJR cord-295206-vetdsk48 55 11 respiratory respiratory JJ cord-295206-vetdsk48 55 12 tract tract NN cord-295206-vetdsk48 55 13 infections infection NNS cord-295206-vetdsk48 55 14 , , , cord-295206-vetdsk48 55 15 including include VBG cord-295206-vetdsk48 55 16 influenza influenza NN cord-295206-vetdsk48 55 17 A a NN cord-295206-vetdsk48 55 18 and and CC cord-295206-vetdsk48 55 19 B B NNP cord-295206-vetdsk48 55 20 , , , cord-295206-vetdsk48 55 21 parainfluenza parainfluenza NN cord-295206-vetdsk48 55 22 , , , cord-295206-vetdsk48 55 23 respiratory respiratory JJ cord-295206-vetdsk48 55 24 syncytial syncytial JJ cord-295206-vetdsk48 55 25 virus virus NN cord-295206-vetdsk48 55 26 , , , cord-295206-vetdsk48 55 27 and and CC cord-295206-vetdsk48 55 28 human human JJ cord-295206-vetdsk48 55 29 metapneumovirus metapneumovirus NN cord-295206-vetdsk48 55 30 and and CC cord-295206-vetdsk48 55 31 upper upper JJ cord-295206-vetdsk48 55 32 respiratory respiratory JJ cord-295206-vetdsk48 55 33 tract tract NN cord-295206-vetdsk48 55 34 infections infection NNS cord-295206-vetdsk48 55 35 , , , cord-295206-vetdsk48 55 36 such such JJ cord-295206-vetdsk48 55 37 as as IN cord-295206-vetdsk48 55 38 rhinovirus rhinovirus NN cord-295206-vetdsk48 55 39 , , , cord-295206-vetdsk48 55 40 corona corona NN cord-295206-vetdsk48 55 41 virus virus NN cord-295206-vetdsk48 55 42 , , , cord-295206-vetdsk48 55 43 and and CC cord-295206-vetdsk48 55 44 adenovirus adenovirus NN cord-295206-vetdsk48 55 45 Bandi Bandi NNP cord-295206-vetdsk48 55 46 et et FW cord-295206-vetdsk48 55 47 al al NNP cord-295206-vetdsk48 55 48 ( ( -LRB- cord-295206-vetdsk48 55 49 2001 2001 CD cord-295206-vetdsk48 55 50 ) ) -RRB- cord-295206-vetdsk48 55 51 . . . cord-295206-vetdsk48 56 1 The the DT cord-295206-vetdsk48 56 2 most most RBS cord-295206-vetdsk48 56 3 common common JJ cord-295206-vetdsk48 56 4 cause cause NN cord-295206-vetdsk48 56 5 of of IN cord-295206-vetdsk48 56 6 acute acute JJ cord-295206-vetdsk48 56 7 bronchitis bronchitis NN cord-295206-vetdsk48 56 8 is be VBZ cord-295206-vetdsk48 56 9 influenza influenza NN cord-295206-vetdsk48 56 10 , , , cord-295206-vetdsk48 56 11 with with IN cord-295206-vetdsk48 56 12 a a DT cord-295206-vetdsk48 56 13 much much RB cord-295206-vetdsk48 56 14 smaller small JJR cord-295206-vetdsk48 56 15 percentage percentage NN cord-295206-vetdsk48 56 16 of of IN cord-295206-vetdsk48 56 17 acute acute JJ cord-295206-vetdsk48 56 18 bronchitis bronchitis NN cord-295206-vetdsk48 56 19 cases case NNS cord-295206-vetdsk48 56 20 resulting result VBG cord-295206-vetdsk48 56 21 from from IN cord-295206-vetdsk48 56 22 bacterial bacterial JJ cord-295206-vetdsk48 56 23 infection infection NN cord-295206-vetdsk48 56 24 . . . cord-295206-vetdsk48 57 1 Chlamydia Chlamydia NNP cord-295206-vetdsk48 57 2 pneumoniae pneumoniae NN cord-295206-vetdsk48 57 3 has have VBZ cord-295206-vetdsk48 57 4 been be VBN cord-295206-vetdsk48 57 5 responsible responsible JJ cord-295206-vetdsk48 57 6 for for IN cord-295206-vetdsk48 57 7 several several JJ cord-295206-vetdsk48 57 8 recent recent JJ cord-295206-vetdsk48 57 9 outbreaks outbreak NNS cord-295206-vetdsk48 57 10 , , , cord-295206-vetdsk48 57 11 particularly particularly RB cord-295206-vetdsk48 57 12 in in IN cord-295206-vetdsk48 57 13 young young JJ cord-295206-vetdsk48 57 14 adults adult NNS cord-295206-vetdsk48 57 15 . . . cord-295206-vetdsk48 58 1 Bordetella bordetella NN cord-295206-vetdsk48 58 2 pertussis pertussis NN cord-295206-vetdsk48 58 3 may may MD cord-295206-vetdsk48 58 4 cause cause VB cord-295206-vetdsk48 58 5 atypical atypical JJ cord-295206-vetdsk48 58 6 symptoms symptom NNS cord-295206-vetdsk48 58 7 resulting result VBG cord-295206-vetdsk48 58 8 in in IN cord-295206-vetdsk48 58 9 prolonged prolonged JJ cord-295206-vetdsk48 58 10 cases case NNS cord-295206-vetdsk48 58 11 of of IN cord-295206-vetdsk48 58 12 acute acute JJ cord-295206-vetdsk48 58 13 bronchitis bronchitis NN cord-295206-vetdsk48 58 14 in in IN cord-295206-vetdsk48 58 15 previously previously RB cord-295206-vetdsk48 58 16 immunized immunize VBN cord-295206-vetdsk48 58 17 adults adult NNS cord-295206-vetdsk48 58 18 . . . cord-295206-vetdsk48 59 1 Mycoplasma mycoplasma NN cord-295206-vetdsk48 59 2 pneumoniae pneumoniae NN cord-295206-vetdsk48 59 3 is be VBZ cord-295206-vetdsk48 59 4 an an DT cord-295206-vetdsk48 59 5 additional additional JJ cord-295206-vetdsk48 59 6 established establish VBN cord-295206-vetdsk48 59 7 etiologic etiologic JJ cord-295206-vetdsk48 59 8 agent agent NN cord-295206-vetdsk48 59 9 of of IN cord-295206-vetdsk48 59 10 acute acute JJ cord-295206-vetdsk48 59 11 bronchitis bronchitis NN cord-295206-vetdsk48 59 12 . . . cord-295206-vetdsk48 60 1 There there EX cord-295206-vetdsk48 60 2 is be VBZ cord-295206-vetdsk48 60 3 very very RB cord-295206-vetdsk48 60 4 little little JJ cord-295206-vetdsk48 60 5 evidence evidence NN cord-295206-vetdsk48 60 6 that that IN cord-295206-vetdsk48 60 7 acute acute JJ cord-295206-vetdsk48 60 8 bronchitis bronchitis NN cord-295206-vetdsk48 60 9 may may MD cord-295206-vetdsk48 60 10 be be VB cord-295206-vetdsk48 60 11 caused cause VBN cord-295206-vetdsk48 60 12 by by IN cord-295206-vetdsk48 60 13 bacterial bacterial JJ cord-295206-vetdsk48 60 14 species specie NNS cord-295206-vetdsk48 60 15 that that WDT cord-295206-vetdsk48 60 16 are be VBP cord-295206-vetdsk48 60 17 characteristic characteristic JJ cord-295206-vetdsk48 60 18 of of IN cord-295206-vetdsk48 60 19 pneumonia pneumonia NN cord-295206-vetdsk48 60 20 infections infection NNS cord-295206-vetdsk48 60 21 ( ( -LRB- cord-295206-vetdsk48 60 22 e.g. e.g. RB cord-295206-vetdsk48 60 23 , , , cord-295206-vetdsk48 60 24 Streptococcus streptococcus NN cord-295206-vetdsk48 60 25 pneumoniae pneumoniae NN cord-295206-vetdsk48 60 26 ) ) -RRB- cord-295206-vetdsk48 60 27 . . . cord-295206-vetdsk48 61 1 Chronic chronic JJ cord-295206-vetdsk48 61 2 bronchitis bronchitis NN cord-295206-vetdsk48 61 3 most most RBS cord-295206-vetdsk48 61 4 frequently frequently RB cord-295206-vetdsk48 61 5 develops develop VBZ cord-295206-vetdsk48 61 6 in in IN cord-295206-vetdsk48 61 7 tobacco tobacco NN cord-295206-vetdsk48 61 8 smokers smoker NNS cord-295206-vetdsk48 61 9 , , , cord-295206-vetdsk48 61 10 approximately approximately RB cord-295206-vetdsk48 61 11 30 30 CD cord-295206-vetdsk48 61 12 - - SYM cord-295206-vetdsk48 61 13 50 50 CD cord-295206-vetdsk48 61 14 % % NN cord-295206-vetdsk48 61 15 of of IN cord-295206-vetdsk48 61 16 whom whom WP cord-295206-vetdsk48 61 17 eventually eventually RB cord-295206-vetdsk48 61 18 show show VBP cord-295206-vetdsk48 61 19 symptoms symptom NNS cord-295206-vetdsk48 61 20 of of IN cord-295206-vetdsk48 61 21 this this DT cord-295206-vetdsk48 61 22 disorder disorder NN cord-295206-vetdsk48 61 23 Viegi Viegi NNP cord-295206-vetdsk48 61 24 ( ( -LRB- cord-295206-vetdsk48 61 25 2001 2001 CD cord-295206-vetdsk48 61 26 ) ) -RRB- cord-295206-vetdsk48 61 27 . . . cord-295206-vetdsk48 62 1 Passive passive JJ cord-295206-vetdsk48 62 2 exposure exposure NN cord-295206-vetdsk48 62 3 to to IN cord-295206-vetdsk48 62 4 smoke smoke NN cord-295206-vetdsk48 62 5 can can MD cord-295206-vetdsk48 62 6 also also RB cord-295206-vetdsk48 62 7 contribute contribute VB cord-295206-vetdsk48 62 8 to to IN cord-295206-vetdsk48 62 9 the the DT cord-295206-vetdsk48 62 10 development development NN cord-295206-vetdsk48 62 11 of of IN cord-295206-vetdsk48 62 12 chronic chronic JJ cord-295206-vetdsk48 62 13 bronchitis bronchitis NN cord-295206-vetdsk48 62 14 . . . cord-295206-vetdsk48 63 1 Other other JJ cord-295206-vetdsk48 63 2 causative causative JJ cord-295206-vetdsk48 63 3 factors factor NNS cord-295206-vetdsk48 63 4 include include VBP cord-295206-vetdsk48 63 5 exposure exposure NN cord-295206-vetdsk48 63 6 to to IN cord-295206-vetdsk48 63 7 indoor indoor JJ cord-295206-vetdsk48 63 8 or or CC cord-295206-vetdsk48 63 9 outdoor outdoor JJ cord-295206-vetdsk48 63 10 air air NN cord-295206-vetdsk48 63 11 pollution pollution NN cord-295206-vetdsk48 63 12 , , , cord-295206-vetdsk48 63 13 occupational occupational JJ cord-295206-vetdsk48 63 14 dusts dust NNS cord-295206-vetdsk48 63 15 ( ( -LRB- cord-295206-vetdsk48 63 16 e.g. e.g. RB cord-295206-vetdsk48 63 17 , , , cord-295206-vetdsk48 63 18 grain grain NN cord-295206-vetdsk48 63 19 , , , cord-295206-vetdsk48 63 20 coal coal NN cord-295206-vetdsk48 63 21 ) ) -RRB- cord-295206-vetdsk48 63 22 , , , cord-295206-vetdsk48 63 23 or or CC cord-295206-vetdsk48 63 24 chemical chemical JJ cord-295206-vetdsk48 63 25 irritants irritant NNS cord-295206-vetdsk48 63 26 ( ( -LRB- cord-295206-vetdsk48 63 27 e.g. e.g. RB cord-295206-vetdsk48 63 28 , , , cord-295206-vetdsk48 63 29 sulfur sulfur NN cord-295206-vetdsk48 63 30 dioxide dioxide NN cord-295206-vetdsk48 63 31 ) ) -RRB- cord-295206-vetdsk48 63 32 . . . cord-295206-vetdsk48 64 1 Chronic chronic JJ cord-295206-vetdsk48 64 2 bronchitis bronchitis NN cord-295206-vetdsk48 64 3 may may MD cord-295206-vetdsk48 64 4 also also RB cord-295206-vetdsk48 64 5 develop develop VB cord-295206-vetdsk48 64 6 in in IN cord-295206-vetdsk48 64 7 people people NNS cord-295206-vetdsk48 64 8 with with IN cord-295206-vetdsk48 64 9 a a DT cord-295206-vetdsk48 64 10 history history NN cord-295206-vetdsk48 64 11 of of IN cord-295206-vetdsk48 64 12 recurrent recurrent JJ cord-295206-vetdsk48 64 13 lung lung NN cord-295206-vetdsk48 64 14 infections infection NNS cord-295206-vetdsk48 64 15 or or CC cord-295206-vetdsk48 64 16 airway airway NN cord-295206-vetdsk48 64 17 hyperresponsiveness hyperresponsiveness NNP cord-295206-vetdsk48 64 18 Hogg Hogg NNP cord-295206-vetdsk48 64 19 ( ( -LRB- cord-295206-vetdsk48 64 20 1999 1999 CD cord-295206-vetdsk48 64 21 ) ) -RRB- cord-295206-vetdsk48 64 22 . . . cord-295206-vetdsk48 65 1 Acute acute JJ cord-295206-vetdsk48 65 2 exacerbations exacerbation NNS cord-295206-vetdsk48 65 3 of of IN cord-295206-vetdsk48 65 4 chronic chronic JJ cord-295206-vetdsk48 65 5 bronchitis bronchitis NN cord-295206-vetdsk48 65 6 are be VBP cord-295206-vetdsk48 65 7 commonly commonly RB cord-295206-vetdsk48 65 8 associated associate VBN cord-295206-vetdsk48 65 9 with with IN cord-295206-vetdsk48 65 10 influenza influenza NN cord-295206-vetdsk48 65 11 , , , cord-295206-vetdsk48 65 12 parainfluenza parainfluenza NNP cord-295206-vetdsk48 65 13 , , , cord-295206-vetdsk48 65 14 coronavirus coronavirus NN cord-295206-vetdsk48 65 15 , , , cord-295206-vetdsk48 65 16 or or CC cord-295206-vetdsk48 65 17 rhinovirus rhinovirus NN cord-295206-vetdsk48 65 18 infections infection NNS cord-295206-vetdsk48 65 19 McCrory McCrory NNP cord-295206-vetdsk48 65 20 et et NNP cord-295206-vetdsk48 65 21 al al NNP cord-295206-vetdsk48 65 22 ( ( -LRB- cord-295206-vetdsk48 65 23 2001 2001 CD cord-295206-vetdsk48 65 24 ) ) -RRB- cord-295206-vetdsk48 65 25 . . . cord-295206-vetdsk48 66 1 Elevated elevated JJ cord-295206-vetdsk48 66 2 levels level NNS cord-295206-vetdsk48 66 3 of of IN cord-295206-vetdsk48 66 4 particulate particulate NN cord-295206-vetdsk48 66 5 air air NN cord-295206-vetdsk48 66 6 pollution pollution NN cord-295206-vetdsk48 66 7 and and CC cord-295206-vetdsk48 66 8 ozone ozone NN cord-295206-vetdsk48 66 9 are be VBP cord-295206-vetdsk48 66 10 also also RB cord-295206-vetdsk48 66 11 associated associate VBN cord-295206-vetdsk48 66 12 with with IN cord-295206-vetdsk48 66 13 acute acute JJ cord-295206-vetdsk48 66 14 exacerbations exacerbation NNS cord-295206-vetdsk48 66 15 . . . cord-295206-vetdsk48 67 1 The the DT cord-295206-vetdsk48 67 2 role role NN cord-295206-vetdsk48 67 3 of of IN cord-295206-vetdsk48 67 4 bacterial bacterial JJ cord-295206-vetdsk48 67 5 infection infection NN cord-295206-vetdsk48 67 6 in in IN cord-295206-vetdsk48 67 7 acute acute JJ cord-295206-vetdsk48 67 8 exacerbation exacerbation NN cord-295206-vetdsk48 67 9 of of IN cord-295206-vetdsk48 67 10 chronic chronic JJ cord-295206-vetdsk48 67 11 bronchitis bronchitis NN cord-295206-vetdsk48 67 12 remains remain VBZ cord-295206-vetdsk48 67 13 controversial controversial JJ cord-295206-vetdsk48 67 14 . . . cord-295206-vetdsk48 68 1 Pathogenic pathogenic JJ cord-295206-vetdsk48 68 2 bacterial bacterial NN cord-295206-vetdsk48 68 3 such such JJ cord-295206-vetdsk48 68 4 as as IN cord-295206-vetdsk48 68 5 Haemophilus haemophilus JJ cord-295206-vetdsk48 68 6 influenzae influenzae NN cord-295206-vetdsk48 68 7 , , , cord-295206-vetdsk48 68 8 Streptococcus streptococcus NN cord-295206-vetdsk48 68 9 pneumoniae pneumoniae NN cord-295206-vetdsk48 68 10 , , , cord-295206-vetdsk48 68 11 and and CC cord-295206-vetdsk48 68 12 Moraxella Moraxella NNP cord-295206-vetdsk48 68 13 catarrhalis catarrhali NNS cord-295206-vetdsk48 68 14 are be VBP cord-295206-vetdsk48 68 15 present present JJ cord-295206-vetdsk48 68 16 in in IN cord-295206-vetdsk48 68 17 the the DT cord-295206-vetdsk48 68 18 sputum sputum NN cord-295206-vetdsk48 68 19 of of IN cord-295206-vetdsk48 68 20 approximately approximately RB cord-295206-vetdsk48 68 21 half half NN cord-295206-vetdsk48 68 22 of of IN cord-295206-vetdsk48 68 23 all all PDT cord-295206-vetdsk48 68 24 those those DT cord-295206-vetdsk48 68 25 experiencing experience VBG cord-295206-vetdsk48 68 26 acute acute JJ cord-295206-vetdsk48 68 27 exacerbations exacerbation NNS cord-295206-vetdsk48 68 28 but but CC cord-295206-vetdsk48 68 29 are be VBP cord-295206-vetdsk48 68 30 also also RB cord-295206-vetdsk48 68 31 frequently frequently RB cord-295206-vetdsk48 68 32 present present JJ cord-295206-vetdsk48 68 33 during during IN cord-295206-vetdsk48 68 34 periods period NNS cord-295206-vetdsk48 68 35 of of IN cord-295206-vetdsk48 68 36 stable stable JJ cord-295206-vetdsk48 68 37 disease disease NN cord-295206-vetdsk48 68 38 Hirschmann Hirschmann NNP cord-295206-vetdsk48 68 39 ( ( -LRB- cord-295206-vetdsk48 68 40 2000 2000 CD cord-295206-vetdsk48 68 41 ) ) -RRB- cord-295206-vetdsk48 68 42 . . . cord-295206-vetdsk48 69 1 Clinical clinical JJ cord-295206-vetdsk48 69 2 trials trial NNS cord-295206-vetdsk48 69 3 have have VBP cord-295206-vetdsk48 69 4 shown show VBN cord-295206-vetdsk48 69 5 that that IN cord-295206-vetdsk48 69 6 antibiotic antibiotic JJ cord-295206-vetdsk48 69 7 therapy therapy NN cord-295206-vetdsk48 69 8 is be VBZ cord-295206-vetdsk48 69 9 helpful helpful JJ cord-295206-vetdsk48 69 10 in in IN cord-295206-vetdsk48 69 11 40 40 CD cord-295206-vetdsk48 69 12 % % NN cord-295206-vetdsk48 69 13 or or CC cord-295206-vetdsk48 69 14 less less JJR cord-295206-vetdsk48 69 15 of of IN cord-295206-vetdsk48 69 16 those those DT cord-295206-vetdsk48 69 17 with with IN cord-295206-vetdsk48 69 18 acute acute JJ cord-295206-vetdsk48 69 19 exacerbations exacerbation NNS cord-295206-vetdsk48 69 20 . . . cord-295206-vetdsk48 70 1 However however RB cord-295206-vetdsk48 70 2 , , , cord-295206-vetdsk48 70 3 in in IN cord-295206-vetdsk48 70 4 the the DT cord-295206-vetdsk48 70 5 subset subset NN cord-295206-vetdsk48 70 6 of of IN cord-295206-vetdsk48 70 7 exacerbations exacerbation NNS cord-295206-vetdsk48 70 8 in in IN cord-295206-vetdsk48 70 9 which which WDT cord-295206-vetdsk48 70 10 purulent purulent JJ cord-295206-vetdsk48 70 11 sputum sputum NN cord-295206-vetdsk48 70 12 is be VBZ cord-295206-vetdsk48 70 13 a a DT cord-295206-vetdsk48 70 14 predominant predominant JJ cord-295206-vetdsk48 70 15 feature feature NN cord-295206-vetdsk48 70 16 , , , cord-295206-vetdsk48 70 17 the the DT cord-295206-vetdsk48 70 18 extent extent NN cord-295206-vetdsk48 70 19 of of IN cord-295206-vetdsk48 70 20 bacterial bacterial JJ cord-295206-vetdsk48 70 21 eradication eradication NN cord-295206-vetdsk48 70 22 correlates correlate VBZ cord-295206-vetdsk48 70 23 with with IN cord-295206-vetdsk48 70 24 the the DT cord-295206-vetdsk48 70 25 degree degree NN cord-295206-vetdsk48 70 26 of of IN cord-295206-vetdsk48 70 27 resolution resolution NN cord-295206-vetdsk48 70 28 of of IN cord-295206-vetdsk48 70 29 the the DT cord-295206-vetdsk48 70 30 exacerbation exacerbation NN cord-295206-vetdsk48 70 31 and and CC cord-295206-vetdsk48 70 32 its -PRON- PRP$ cord-295206-vetdsk48 70 33 associated associated JJ cord-295206-vetdsk48 70 34 inflammation inflammation NN cord-295206-vetdsk48 70 35 White White NNP cord-295206-vetdsk48 70 36 et et FW cord-295206-vetdsk48 70 37 al al NNP cord-295206-vetdsk48 70 38 ( ( -LRB- cord-295206-vetdsk48 70 39 2003 2003 CD cord-295206-vetdsk48 70 40 ) ) -RRB- cord-295206-vetdsk48 70 41 . . . cord-295206-vetdsk48 71 1 Thus thus RB cord-295206-vetdsk48 71 2 , , , cord-295206-vetdsk48 71 3 an an DT cord-295206-vetdsk48 71 4 increase increase NN cord-295206-vetdsk48 71 5 in in IN cord-295206-vetdsk48 71 6 bacterial bacterial JJ cord-295206-vetdsk48 71 7 load load NN cord-295206-vetdsk48 71 8 , , , cord-295206-vetdsk48 71 9 acquisition acquisition NN cord-295206-vetdsk48 71 10 of of IN cord-295206-vetdsk48 71 11 a a DT cord-295206-vetdsk48 71 12 new new JJ cord-295206-vetdsk48 71 13 bacterial bacterial JJ cord-295206-vetdsk48 71 14 pathogen pathogen NN cord-295206-vetdsk48 71 15 , , , cord-295206-vetdsk48 71 16 or or CC cord-295206-vetdsk48 71 17 a a DT cord-295206-vetdsk48 71 18 change change NN cord-295206-vetdsk48 71 19 in in IN cord-295206-vetdsk48 71 20 the the DT cord-295206-vetdsk48 71 21 antigenic antigenic JJ cord-295206-vetdsk48 71 22 makeup makeup NN cord-295206-vetdsk48 71 23 of of IN cord-295206-vetdsk48 71 24 the the DT cord-295206-vetdsk48 71 25 resident resident JJ cord-295206-vetdsk48 71 26 bacterial bacterial JJ cord-295206-vetdsk48 71 27 population population NN cord-295206-vetdsk48 71 28 , , , cord-295206-vetdsk48 71 29 may may MD cord-295206-vetdsk48 71 30 be be VB cord-295206-vetdsk48 71 31 responsible responsible JJ cord-295206-vetdsk48 71 32 for for IN cord-295206-vetdsk48 71 33 certain certain JJ cord-295206-vetdsk48 71 34 acute acute JJ cord-295206-vetdsk48 71 35 exacerbations exacerbation NNS cord-295206-vetdsk48 71 36 of of IN cord-295206-vetdsk48 71 37 chronic chronic JJ cord-295206-vetdsk48 71 38 bronchitis bronchitis NN cord-295206-vetdsk48 71 39 . . . cord-295206-vetdsk48 72 1 The the DT cord-295206-vetdsk48 72 2 role role NN cord-295206-vetdsk48 72 3 of of IN cord-295206-vetdsk48 72 4 bacterial bacterial JJ cord-295206-vetdsk48 72 5 infection infection NN cord-295206-vetdsk48 72 6 in in IN cord-295206-vetdsk48 72 7 the the DT cord-295206-vetdsk48 72 8 progression progression NN cord-295206-vetdsk48 72 9 of of IN cord-295206-vetdsk48 72 10 chronic chronic JJ cord-295206-vetdsk48 72 11 bronchitis bronchitis NN cord-295206-vetdsk48 72 12 is be VBZ cord-295206-vetdsk48 72 13 unclear unclear JJ cord-295206-vetdsk48 72 14 Wilson Wilson NNP cord-295206-vetdsk48 72 15 ( ( -LRB- cord-295206-vetdsk48 72 16 1998 1998 CD cord-295206-vetdsk48 72 17 ) ) -RRB- cord-295206-vetdsk48 72 18 . . . cord-295206-vetdsk48 73 1 Acute acute JJ cord-295206-vetdsk48 73 2 bronchitis bronchitis NN cord-295206-vetdsk48 73 3 is be VBZ cord-295206-vetdsk48 73 4 a a DT cord-295206-vetdsk48 73 5 widespread widespread JJ cord-295206-vetdsk48 73 6 condition condition NN cord-295206-vetdsk48 73 7 that that WDT cord-295206-vetdsk48 73 8 usually usually RB cord-295206-vetdsk48 73 9 occurs occur VBZ cord-295206-vetdsk48 73 10 in in IN cord-295206-vetdsk48 73 11 outbreaks outbreak NNS cord-295206-vetdsk48 73 12 and and CC cord-295206-vetdsk48 73 13 epidemics epidemic NNS cord-295206-vetdsk48 73 14 , , , cord-295206-vetdsk48 73 15 especially especially RB cord-295206-vetdsk48 73 16 during during IN cord-295206-vetdsk48 73 17 the the DT cord-295206-vetdsk48 73 18 winter winter NN cord-295206-vetdsk48 73 19 months month NNS cord-295206-vetdsk48 73 20 . . . cord-295206-vetdsk48 74 1 Its -PRON- PRP$ cord-295206-vetdsk48 74 2 incidence incidence NN cord-295206-vetdsk48 74 3 is be VBZ cord-295206-vetdsk48 74 4 approximately approximately RB cord-295206-vetdsk48 74 5 50 50 CD cord-295206-vetdsk48 74 6 - - SYM cord-295206-vetdsk48 74 7 60 60 CD cord-295206-vetdsk48 74 8 cases case NNS cord-295206-vetdsk48 74 9 per per IN cord-295206-vetdsk48 74 10 1,000 1,000 CD cord-295206-vetdsk48 74 11 persons person NNS cord-295206-vetdsk48 74 12 per per IN cord-295206-vetdsk48 74 13 year year NN cord-295206-vetdsk48 74 14 File file NN cord-295206-vetdsk48 74 15 ( ( -LRB- cord-295206-vetdsk48 74 16 2000 2000 CD cord-295206-vetdsk48 74 17 ) ) -RRB- cord-295206-vetdsk48 74 18 . . . cord-295206-vetdsk48 75 1 An an DT cord-295206-vetdsk48 75 2 elevated elevated JJ cord-295206-vetdsk48 75 3 risk risk NN cord-295206-vetdsk48 75 4 for for IN cord-295206-vetdsk48 75 5 the the DT cord-295206-vetdsk48 75 6 development development NN cord-295206-vetdsk48 75 7 of of IN cord-295206-vetdsk48 75 8 acute acute JJ cord-295206-vetdsk48 75 9 bronchitis bronchitis NN cord-295206-vetdsk48 75 10 is be VBZ cord-295206-vetdsk48 75 11 seen see VBN cord-295206-vetdsk48 75 12 among among IN cord-295206-vetdsk48 75 13 the the DT cord-295206-vetdsk48 75 14 very very RB cord-295206-vetdsk48 75 15 young young JJ cord-295206-vetdsk48 75 16 and and CC cord-295206-vetdsk48 75 17 the the DT cord-295206-vetdsk48 75 18 elderly elderly JJ cord-295206-vetdsk48 75 19 , , , cord-295206-vetdsk48 75 20 smokers smoker NNS cord-295206-vetdsk48 75 21 , , , cord-295206-vetdsk48 75 22 immunocompromised immunocompromised JJ cord-295206-vetdsk48 75 23 individuals individual NNS cord-295206-vetdsk48 75 24 , , , cord-295206-vetdsk48 75 25 persons person NNS cord-295206-vetdsk48 75 26 with with IN cord-295206-vetdsk48 75 27 comorbid comorbid NN cord-295206-vetdsk48 75 28 conditions condition NNS cord-295206-vetdsk48 75 29 , , , cord-295206-vetdsk48 75 30 such such JJ cord-295206-vetdsk48 75 31 as as IN cord-295206-vetdsk48 75 32 cardiovascular cardiovascular JJ cord-295206-vetdsk48 75 33 or or CC cord-295206-vetdsk48 75 34 pulmonary pulmonary JJ cord-295206-vetdsk48 75 35 disease disease NN cord-295206-vetdsk48 75 36 , , , cord-295206-vetdsk48 75 37 and and CC cord-295206-vetdsk48 75 38 alcoholics alcoholic NNS cord-295206-vetdsk48 75 39 . . . cord-295206-vetdsk48 76 1 Such such JJ cord-295206-vetdsk48 76 2 individuals individual NNS cord-295206-vetdsk48 76 3 are be VBP cord-295206-vetdsk48 76 4 also also RB cord-295206-vetdsk48 76 5 at at IN cord-295206-vetdsk48 76 6 increased increase VBN cord-295206-vetdsk48 76 7 risk risk NN cord-295206-vetdsk48 76 8 for for IN cord-295206-vetdsk48 76 9 developing develop VBG cord-295206-vetdsk48 76 10 complications complication NNS cord-295206-vetdsk48 76 11 such such JJ cord-295206-vetdsk48 76 12 as as IN cord-295206-vetdsk48 76 13 pneumonia pneumonia NN cord-295206-vetdsk48 76 14 . . . cord-295206-vetdsk48 77 1 Chronic chronic JJ cord-295206-vetdsk48 77 2 bronchitis bronchitis NN cord-295206-vetdsk48 77 3 and and CC cord-295206-vetdsk48 77 4 emphysema emphysema NN cord-295206-vetdsk48 77 5 are be VBP cord-295206-vetdsk48 77 6 related related JJ cord-295206-vetdsk48 77 7 manifestations manifestation NNS cord-295206-vetdsk48 77 8 of of IN cord-295206-vetdsk48 77 9 chronic chronic JJ cord-295206-vetdsk48 77 10 obstructive obstructive JJ cord-295206-vetdsk48 77 11 pulmonary pulmonary JJ cord-295206-vetdsk48 77 12 disease disease NN cord-295206-vetdsk48 77 13 ( ( -LRB- cord-295206-vetdsk48 77 14 COPD COPD NNP cord-295206-vetdsk48 77 15 ) ) -RRB- cord-295206-vetdsk48 77 16 and and CC cord-295206-vetdsk48 77 17 often often RB cord-295206-vetdsk48 77 18 coexist coexist VBP cord-295206-vetdsk48 77 19 in in IN cord-295206-vetdsk48 77 20 an an DT cord-295206-vetdsk48 77 21 individual individual NN cord-295206-vetdsk48 77 22 . . . cord-295206-vetdsk48 78 1 According accord VBG cord-295206-vetdsk48 78 2 to to IN cord-295206-vetdsk48 78 3 the the DT cord-295206-vetdsk48 78 4 2001 2001 CD cord-295206-vetdsk48 78 5 National National NNP cord-295206-vetdsk48 78 6 Health Health NNP cord-295206-vetdsk48 78 7 Interview Interview NNP cord-295206-vetdsk48 78 8 Survey Survey NNP cord-295206-vetdsk48 78 9 , , , cord-295206-vetdsk48 78 10 9.2 9.2 CD cord-295206-vetdsk48 78 11 million million CD cord-295206-vetdsk48 78 12 Americans Americans NNPS cord-295206-vetdsk48 78 13 have have VBP cord-295206-vetdsk48 78 14 been be VBN cord-295206-vetdsk48 78 15 diagnosed diagnose VBN cord-295206-vetdsk48 78 16 with with IN cord-295206-vetdsk48 78 17 chronic chronic JJ cord-295206-vetdsk48 78 18 bronchitis bronchitis NN cord-295206-vetdsk48 78 19 , , , cord-295206-vetdsk48 78 20 2 2 CD cord-295206-vetdsk48 78 21 million million CD cord-295206-vetdsk48 78 22 with with IN cord-295206-vetdsk48 78 23 emphysema emphysema NN cord-295206-vetdsk48 78 24 , , , cord-295206-vetdsk48 78 25 and and CC cord-295206-vetdsk48 78 26 0.9 0.9 CD cord-295206-vetdsk48 78 27 million million CD cord-295206-vetdsk48 78 28 with with IN cord-295206-vetdsk48 78 29 both both DT cord-295206-vetdsk48 78 30 Barnes Barnes NNP cord-295206-vetdsk48 78 31 et et NNP cord-295206-vetdsk48 78 32 al al NNP cord-295206-vetdsk48 78 33 ( ( -LRB- cord-295206-vetdsk48 78 34 2003 2003 CD cord-295206-vetdsk48 78 35 ) ) -RRB- cord-295206-vetdsk48 78 36 . . . cord-295206-vetdsk48 79 1 In in IN cord-295206-vetdsk48 79 2 the the DT cord-295206-vetdsk48 79 3 US US NNP cord-295206-vetdsk48 79 4 , , , cord-295206-vetdsk48 79 5 COPD COPD NNP cord-295206-vetdsk48 79 6 is be VBZ cord-295206-vetdsk48 79 7 the the DT cord-295206-vetdsk48 79 8 primary primary JJ cord-295206-vetdsk48 79 9 cause cause NN cord-295206-vetdsk48 79 10 of of IN cord-295206-vetdsk48 79 11 death death NN cord-295206-vetdsk48 79 12 for for IN cord-295206-vetdsk48 79 13 over over IN cord-295206-vetdsk48 79 14 120,000 120,000 CD cord-295206-vetdsk48 79 15 people people NNS cord-295206-vetdsk48 79 16 a a DT cord-295206-vetdsk48 79 17 year year NN cord-295206-vetdsk48 79 18 . . . cord-295206-vetdsk48 80 1 A a DT cord-295206-vetdsk48 80 2 large large JJ cord-295206-vetdsk48 80 3 number number NN cord-295206-vetdsk48 80 4 of of IN cord-295206-vetdsk48 80 5 cases case NNS cord-295206-vetdsk48 80 6 may may MD cord-295206-vetdsk48 80 7 be be VB cord-295206-vetdsk48 80 8 undiagnosed undiagnosed JJ cord-295206-vetdsk48 80 9 , , , cord-295206-vetdsk48 80 10 as as IN cord-295206-vetdsk48 80 11 a a DT cord-295206-vetdsk48 80 12 recent recent JJ cord-295206-vetdsk48 80 13 survey survey NN cord-295206-vetdsk48 80 14 involving involve VBG cord-295206-vetdsk48 80 15 the the DT cord-295206-vetdsk48 80 16 direct direct JJ cord-295206-vetdsk48 80 17 measurement measurement NN cord-295206-vetdsk48 80 18 of of IN cord-295206-vetdsk48 80 19 pulmonary pulmonary JJ cord-295206-vetdsk48 80 20 function function NN cord-295206-vetdsk48 80 21 suggests suggest VBZ cord-295206-vetdsk48 80 22 that that IN cord-295206-vetdsk48 80 23 nearly nearly RB cord-295206-vetdsk48 80 24 24 24 CD cord-295206-vetdsk48 80 25 million million CD cord-295206-vetdsk48 80 26 individuals individual NNS cord-295206-vetdsk48 80 27 in in IN cord-295206-vetdsk48 80 28 the the DT cord-295206-vetdsk48 80 29 US US NNP cord-295206-vetdsk48 80 30 suffer suffer VB cord-295206-vetdsk48 80 31 from from IN cord-295206-vetdsk48 80 32 COPD COPD NNP cord-295206-vetdsk48 80 33 Mannino Mannino NNP cord-295206-vetdsk48 80 34 et et FW cord-295206-vetdsk48 80 35 al al NNP cord-295206-vetdsk48 80 36 ( ( -LRB- cord-295206-vetdsk48 80 37 2002 2002 CD cord-295206-vetdsk48 80 38 ) ) -RRB- cord-295206-vetdsk48 80 39 . . . cord-295206-vetdsk48 81 1 Chronic chronic JJ cord-295206-vetdsk48 81 2 bronchitis bronchitis NN cord-295206-vetdsk48 81 3 is be VBZ cord-295206-vetdsk48 81 4 most most RBS cord-295206-vetdsk48 81 5 commonly commonly RB cord-295206-vetdsk48 81 6 seen see VBN cord-295206-vetdsk48 81 7 in in IN cord-295206-vetdsk48 81 8 individuals individual NNS cord-295206-vetdsk48 81 9 over over IN cord-295206-vetdsk48 81 10 the the DT cord-295206-vetdsk48 81 11 age age NN cord-295206-vetdsk48 81 12 of of IN cord-295206-vetdsk48 81 13 40 40 CD cord-295206-vetdsk48 81 14 . . . cord-295206-vetdsk48 82 1 It -PRON- PRP cord-295206-vetdsk48 82 2 is be VBZ cord-295206-vetdsk48 82 3 more more RBR cord-295206-vetdsk48 82 4 common common JJ cord-295206-vetdsk48 82 5 in in IN cord-295206-vetdsk48 82 6 women woman NNS cord-295206-vetdsk48 82 7 than than IN cord-295206-vetdsk48 82 8 men man NNS cord-295206-vetdsk48 82 9 across across IN cord-295206-vetdsk48 82 10 all all DT cord-295206-vetdsk48 82 11 age age NN cord-295206-vetdsk48 82 12 groups group NNS cord-295206-vetdsk48 82 13 and and CC cord-295206-vetdsk48 82 14 may may MD cord-295206-vetdsk48 82 15 be be VB cord-295206-vetdsk48 82 16 more more RBR cord-295206-vetdsk48 82 17 severe severe JJ cord-295206-vetdsk48 82 18 in in IN cord-295206-vetdsk48 82 19 women woman NNS cord-295206-vetdsk48 82 20 Barnes Barnes NNP cord-295206-vetdsk48 82 21 et et NNP cord-295206-vetdsk48 82 22 al al NNP cord-295206-vetdsk48 82 23 ( ( -LRB- cord-295206-vetdsk48 82 24 2003 2003 CD cord-295206-vetdsk48 82 25 ) ) -RRB- cord-295206-vetdsk48 82 26 . . . cord-295206-vetdsk48 83 1 In in IN cord-295206-vetdsk48 83 2 the the DT cord-295206-vetdsk48 83 3 25 25 CD cord-295206-vetdsk48 83 4 - - SYM cord-295206-vetdsk48 83 5 44 44 CD cord-295206-vetdsk48 83 6 and and CC cord-295206-vetdsk48 83 7 65 65 CD cord-295206-vetdsk48 83 8 + + CC cord-295206-vetdsk48 83 9 age age NN cord-295206-vetdsk48 83 10 groups group NNS cord-295206-vetdsk48 83 11 , , , cord-295206-vetdsk48 83 12 it -PRON- PRP cord-295206-vetdsk48 83 13 is be VBZ cord-295206-vetdsk48 83 14 more more RBR cord-295206-vetdsk48 83 15 common common JJ cord-295206-vetdsk48 83 16 in in IN cord-295206-vetdsk48 83 17 whites white NNS cord-295206-vetdsk48 83 18 than than IN cord-295206-vetdsk48 83 19 blacks black NNS cord-295206-vetdsk48 83 20 , , , cord-295206-vetdsk48 83 21 whereas whereas IN cord-295206-vetdsk48 83 22 the the DT cord-295206-vetdsk48 83 23 reverse reverse NN cord-295206-vetdsk48 83 24 is be VBZ cord-295206-vetdsk48 83 25 true true JJ cord-295206-vetdsk48 83 26 in in IN cord-295206-vetdsk48 83 27 the the DT cord-295206-vetdsk48 83 28 45 45 CD cord-295206-vetdsk48 83 29 - - SYM cord-295206-vetdsk48 83 30 64 64 CD cord-295206-vetdsk48 83 31 age age NN cord-295206-vetdsk48 83 32 group group NN cord-295206-vetdsk48 83 33 . . . cord-295206-vetdsk48 84 1 The the DT cord-295206-vetdsk48 84 2 most most RBS cord-295206-vetdsk48 84 3 significant significant JJ cord-295206-vetdsk48 84 4 risk risk NN cord-295206-vetdsk48 84 5 factor factor NN cord-295206-vetdsk48 84 6 for for IN cord-295206-vetdsk48 84 7 the the DT cord-295206-vetdsk48 84 8 development development NN cord-295206-vetdsk48 84 9 of of IN cord-295206-vetdsk48 84 10 chronic chronic JJ cord-295206-vetdsk48 84 11 bronchitis bronchitis NN cord-295206-vetdsk48 84 12 is be VBZ cord-295206-vetdsk48 84 13 cigarette cigarette NN cord-295206-vetdsk48 84 14 smoking smoking NN cord-295206-vetdsk48 84 15 , , , cord-295206-vetdsk48 84 16 with with IN cord-295206-vetdsk48 84 17 morbidity morbidity NN cord-295206-vetdsk48 84 18 and and CC cord-295206-vetdsk48 84 19 mortality mortality NN cord-295206-vetdsk48 84 20 increasing increase VBG cord-295206-vetdsk48 84 21 in in IN cord-295206-vetdsk48 84 22 proportion proportion NN cord-295206-vetdsk48 84 23 to to IN cord-295206-vetdsk48 84 24 the the DT cord-295206-vetdsk48 84 25 extent extent NN cord-295206-vetdsk48 84 26 and and CC cord-295206-vetdsk48 84 27 duration duration NN cord-295206-vetdsk48 84 28 of of IN cord-295206-vetdsk48 84 29 smoking smoke VBG cord-295206-vetdsk48 84 30 Viegi Viegi NNP cord-295206-vetdsk48 84 31 ( ( -LRB- cord-295206-vetdsk48 84 32 2001 2001 CD cord-295206-vetdsk48 84 33 ) ) -RRB- cord-295206-vetdsk48 84 34 . . . cord-295206-vetdsk48 85 1 Occupational occupational JJ cord-295206-vetdsk48 85 2 exposures exposure NNS cord-295206-vetdsk48 85 3 to to IN cord-295206-vetdsk48 85 4 dusts dust NNS cord-295206-vetdsk48 85 5 ( ( -LRB- cord-295206-vetdsk48 85 6 e.g. e.g. RB cord-295206-vetdsk48 85 7 , , , cord-295206-vetdsk48 85 8 coal coal NN cord-295206-vetdsk48 85 9 , , , cord-295206-vetdsk48 85 10 grain grain NN cord-295206-vetdsk48 85 11 , , , cord-295206-vetdsk48 85 12 and and CC cord-295206-vetdsk48 85 13 cadmium cadmium NN cord-295206-vetdsk48 85 14 and and CC cord-295206-vetdsk48 85 15 other other JJ cord-295206-vetdsk48 85 16 heavy heavy JJ cord-295206-vetdsk48 85 17 metals metal NNS cord-295206-vetdsk48 85 18 ) ) -RRB- cord-295206-vetdsk48 85 19 and and CC cord-295206-vetdsk48 85 20 industrial industrial JJ cord-295206-vetdsk48 85 21 chemicals chemical NNS cord-295206-vetdsk48 85 22 ( ( -LRB- cord-295206-vetdsk48 85 23 e.g. e.g. RB cord-295206-vetdsk48 85 24 , , , cord-295206-vetdsk48 85 25 isocyanates isocyanate NNS cord-295206-vetdsk48 85 26 , , , cord-295206-vetdsk48 85 27 certain certain JJ cord-295206-vetdsk48 85 28 adhesives adhesive NNS cord-295206-vetdsk48 85 29 , , , cord-295206-vetdsk48 85 30 and and CC cord-295206-vetdsk48 85 31 welding welding NN cord-295206-vetdsk48 85 32 fumes fume NNS cord-295206-vetdsk48 85 33 ) ) -RRB- cord-295206-vetdsk48 85 34 also also RB cord-295206-vetdsk48 85 35 pose pose VBP cord-295206-vetdsk48 85 36 significant significant JJ cord-295206-vetdsk48 85 37 risk risk NN cord-295206-vetdsk48 85 38 for for IN cord-295206-vetdsk48 85 39 the the DT cord-295206-vetdsk48 85 40 development development NN cord-295206-vetdsk48 85 41 of of IN cord-295206-vetdsk48 85 42 chronic chronic JJ cord-295206-vetdsk48 85 43 bronchitis bronchitis NN cord-295206-vetdsk48 85 44 . . . cord-295206-vetdsk48 86 1 Environmental environmental JJ cord-295206-vetdsk48 86 2 tobacco tobacco NN cord-295206-vetdsk48 86 3 smoke smoke NN cord-295206-vetdsk48 86 4 and and CC cord-295206-vetdsk48 86 5 air air NN cord-295206-vetdsk48 86 6 pollution pollution NN cord-295206-vetdsk48 86 7 are be VBP cord-295206-vetdsk48 86 8 also also RB cord-295206-vetdsk48 86 9 associated associate VBN cord-295206-vetdsk48 86 10 with with IN cord-295206-vetdsk48 86 11 an an DT cord-295206-vetdsk48 86 12 increased increase VBN cord-295206-vetdsk48 86 13 risk risk NN cord-295206-vetdsk48 86 14 of of IN cord-295206-vetdsk48 86 15 developing develop VBG cord-295206-vetdsk48 86 16 COPD COPD NNP cord-295206-vetdsk48 86 17 . . . cord-295206-vetdsk48 87 1 A a DT cord-295206-vetdsk48 87 2 history history NN cord-295206-vetdsk48 87 3 of of IN cord-295206-vetdsk48 87 4 childhood childhood NN cord-295206-vetdsk48 87 5 respiratory respiratory JJ cord-295206-vetdsk48 87 6 infections infection NNS cord-295206-vetdsk48 87 7 correlates correlate VBZ cord-295206-vetdsk48 87 8 with with IN cord-295206-vetdsk48 87 9 an an DT cord-295206-vetdsk48 87 10 increased increase VBN cord-295206-vetdsk48 87 11 risk risk NN cord-295206-vetdsk48 87 12 of of IN cord-295206-vetdsk48 87 13 COPD COPD NNP cord-295206-vetdsk48 87 14 Hogg Hogg NNP cord-295206-vetdsk48 87 15 ( ( -LRB- cord-295206-vetdsk48 87 16 1999 1999 CD cord-295206-vetdsk48 87 17 ) ) -RRB- cord-295206-vetdsk48 87 18 . . . cord-295206-vetdsk48 88 1 Latent latent JJ cord-295206-vetdsk48 88 2 infection infection NN cord-295206-vetdsk48 88 3 with with IN cord-295206-vetdsk48 88 4 adenovirus adenovirus NN cord-295206-vetdsk48 88 5 may may MD cord-295206-vetdsk48 88 6 enhance enhance VB cord-295206-vetdsk48 88 7 the the DT cord-295206-vetdsk48 88 8 inflammatory inflammatory JJ cord-295206-vetdsk48 88 9 response response NN cord-295206-vetdsk48 88 10 to to IN cord-295206-vetdsk48 88 11 environmental environmental JJ cord-295206-vetdsk48 88 12 causes cause NNS cord-295206-vetdsk48 88 13 of of IN cord-295206-vetdsk48 88 14 chronic chronic JJ cord-295206-vetdsk48 88 15 bronchitis bronchitis NN cord-295206-vetdsk48 88 16 , , , cord-295206-vetdsk48 88 17 as as IN cord-295206-vetdsk48 88 18 may may MD cord-295206-vetdsk48 88 19 infection infection NN cord-295206-vetdsk48 88 20 with with IN cord-295206-vetdsk48 88 21 the the DT cord-295206-vetdsk48 88 22 ulcerogenic ulcerogenic JJ cord-295206-vetdsk48 88 23 bacterium bacterium NN cord-295206-vetdsk48 88 24 Helicobacter Helicobacter NNP cord-295206-vetdsk48 88 25 pyloriRoussos pyloriroussos NN cord-295206-vetdsk48 88 26 et et NNP cord-295206-vetdsk48 88 27 al al NNP cord-295206-vetdsk48 88 28 ( ( -LRB- cord-295206-vetdsk48 88 29 2003 2003 CD cord-295206-vetdsk48 88 30 ) ) -RRB- cord-295206-vetdsk48 88 31 . . . cord-295206-vetdsk48 89 1 Colonization colonization NN cord-295206-vetdsk48 89 2 of of IN cord-295206-vetdsk48 89 3 the the DT cord-295206-vetdsk48 89 4 lower low JJR cord-295206-vetdsk48 89 5 airways airway NNS cord-295206-vetdsk48 89 6 with with IN cord-295206-vetdsk48 89 7 Haemophilus Haemophilus NNP cord-295206-vetdsk48 89 8 influenzae influenzae NN cord-295206-vetdsk48 89 9 , , , cord-295206-vetdsk48 89 10 a a DT cord-295206-vetdsk48 89 11 pulmonary pulmonary JJ cord-295206-vetdsk48 89 12 pathogen pathogen NN cord-295206-vetdsk48 89 13 , , , cord-295206-vetdsk48 89 14 may may MD cord-295206-vetdsk48 89 15 be be VB cord-295206-vetdsk48 89 16 associated associate VBN cord-295206-vetdsk48 89 17 with with IN cord-295206-vetdsk48 89 18 chronic chronic JJ cord-295206-vetdsk48 89 19 bronchitis bronchitis NN cord-295206-vetdsk48 89 20 and and CC cord-295206-vetdsk48 89 21 its -PRON- PRP$ cord-295206-vetdsk48 89 22 acute acute JJ cord-295206-vetdsk48 89 23 exacerbations exacerbation NNS cord-295206-vetdsk48 89 24 Wilson Wilson NNP cord-295206-vetdsk48 89 25 ( ( -LRB- cord-295206-vetdsk48 89 26 1998 1998 CD cord-295206-vetdsk48 89 27 ) ) -RRB- cord-295206-vetdsk48 89 28 , , , cord-295206-vetdsk48 89 29 Bandi Bandi NNP cord-295206-vetdsk48 89 30 et et NNP cord-295206-vetdsk48 89 31 al al NNP cord-295206-vetdsk48 89 32 ( ( -LRB- cord-295206-vetdsk48 89 33 2001 2001 CD cord-295206-vetdsk48 89 34 . . . cord-295206-vetdsk48 90 1 Host host NN cord-295206-vetdsk48 90 2 factors factor NNS cord-295206-vetdsk48 90 3 are be VBP cord-295206-vetdsk48 90 4 also also RB cord-295206-vetdsk48 90 5 involved involve VBN cord-295206-vetdsk48 90 6 in in IN cord-295206-vetdsk48 90 7 the the DT cord-295206-vetdsk48 90 8 development development NN cord-295206-vetdsk48 90 9 of of IN cord-295206-vetdsk48 90 10 COP COP NNP cord-295206-vetdsk48 90 11 D. D. NNP cord-295206-vetdsk48 90 12 Low Low NNP cord-295206-vetdsk48 90 13 socio socio JJ cord-295206-vetdsk48 90 14 - - HYPH cord-295206-vetdsk48 90 15 economic economic JJ cord-295206-vetdsk48 90 16 status status NN cord-295206-vetdsk48 90 17 , , , cord-295206-vetdsk48 90 18 high high JJ cord-295206-vetdsk48 90 19 alcohol alcohol NN cord-295206-vetdsk48 90 20 consumption consumption NN cord-295206-vetdsk48 90 21 , , , cord-295206-vetdsk48 90 22 and and CC cord-295206-vetdsk48 90 23 a a DT cord-295206-vetdsk48 90 24 tendency tendency NN cord-295206-vetdsk48 90 25 toward toward IN cord-295206-vetdsk48 90 26 atopic atopic JJ cord-295206-vetdsk48 90 27 allergic allergic JJ cord-295206-vetdsk48 90 28 reactions reaction NNS cord-295206-vetdsk48 90 29 and and CC cord-295206-vetdsk48 90 30 hypersensitivity hypersensitivity NN cord-295206-vetdsk48 90 31 are be VBP cord-295206-vetdsk48 90 32 associated associate VBN cord-295206-vetdsk48 90 33 with with IN cord-295206-vetdsk48 90 34 COPD COPD NNP cord-295206-vetdsk48 90 35 Viegi Viegi NNP cord-295206-vetdsk48 90 36 ( ( -LRB- cord-295206-vetdsk48 90 37 2001 2001 CD cord-295206-vetdsk48 90 38 ) ) -RRB- cord-295206-vetdsk48 90 39 . . . cord-295206-vetdsk48 91 1 Low low JJ cord-295206-vetdsk48 91 2 dietary dietary JJ cord-295206-vetdsk48 91 3 intake intake NN cord-295206-vetdsk48 91 4 of of IN cord-295206-vetdsk48 91 5 fresh fresh JJ cord-295206-vetdsk48 91 6 fruit fruit NN cord-295206-vetdsk48 91 7 and and CC cord-295206-vetdsk48 91 8 vegetables vegetable NNS cord-295206-vetdsk48 91 9 , , , cord-295206-vetdsk48 92 1 antioxidants antioxidant NNS cord-295206-vetdsk48 92 2 such such JJ cord-295206-vetdsk48 92 3 as as IN cord-295206-vetdsk48 92 4 vitamin vitamin NN cord-295206-vetdsk48 92 5 C c NN cord-295206-vetdsk48 92 6 and and CC cord-295206-vetdsk48 92 7 beta beta NN cord-295206-vetdsk48 92 8 - - HYPH cord-295206-vetdsk48 92 9 carotene carotene NN cord-295206-vetdsk48 92 10 , , , cord-295206-vetdsk48 92 11 fish fish NN cord-295206-vetdsk48 92 12 , , , cord-295206-vetdsk48 92 13 and and CC cord-295206-vetdsk48 92 14 omega-3 omega-3 JJR cord-295206-vetdsk48 92 15 fatty fatty JJ cord-295206-vetdsk48 92 16 acids acid NNS cord-295206-vetdsk48 92 17 has have VBZ cord-295206-vetdsk48 92 18 also also RB cord-295206-vetdsk48 92 19 been be VBN cord-295206-vetdsk48 92 20 associated associate VBN cord-295206-vetdsk48 92 21 with with IN cord-295206-vetdsk48 92 22 impaired impaired JJ cord-295206-vetdsk48 92 23 lung lung NN cord-295206-vetdsk48 92 24 function function NN cord-295206-vetdsk48 92 25 Romieu Romieu NNP cord-295206-vetdsk48 92 26 and and CC cord-295206-vetdsk48 92 27 Trenga Trenga NNP cord-295206-vetdsk48 92 28 ( ( -LRB- cord-295206-vetdsk48 92 29 2001 2001 CD cord-295206-vetdsk48 92 30 ) ) -RRB- cord-295206-vetdsk48 92 31 . . . cord-295206-vetdsk48 93 1 An an DT cord-295206-vetdsk48 93 2 inherited inherit VBN cord-295206-vetdsk48 93 3 deficiency deficiency NN cord-295206-vetdsk48 93 4 in in IN cord-295206-vetdsk48 93 5 alpha-1 alpha-1 NN cord-295206-vetdsk48 93 6 antitrypsin antitrypsin NN cord-295206-vetdsk48 93 7 ( ( -LRB- cord-295206-vetdsk48 93 8 alpha-1 alpha-1 NN cord-295206-vetdsk48 93 9 proteinase proteinase NN cord-295206-vetdsk48 93 10 inhibitor inhibitor NN cord-295206-vetdsk48 93 11 ) ) -RRB- cord-295206-vetdsk48 93 12 results result NNS cord-295206-vetdsk48 93 13 in in IN cord-295206-vetdsk48 93 14 earlyonset earlyonset NNP cord-295206-vetdsk48 93 15 emphysema emphysema NN cord-295206-vetdsk48 93 16 Viegi Viegi NNP cord-295206-vetdsk48 93 17 ( ( -LRB- cord-295206-vetdsk48 93 18 2001 2001 CD cord-295206-vetdsk48 93 19 ) ) -RRB- cord-295206-vetdsk48 93 20 . . . cord-295206-vetdsk48 94 1 Genetic genetic JJ cord-295206-vetdsk48 94 2 factors factor NNS cord-295206-vetdsk48 94 3 may may MD cord-295206-vetdsk48 94 4 also also RB cord-295206-vetdsk48 94 5 be be VB cord-295206-vetdsk48 94 6 involved involve VBN cord-295206-vetdsk48 94 7 in in IN cord-295206-vetdsk48 94 8 the the DT cord-295206-vetdsk48 94 9 development development NN cord-295206-vetdsk48 94 10 of of IN cord-295206-vetdsk48 94 11 chronic chronic JJ cord-295206-vetdsk48 94 12 bronchitis bronchitis NN cord-295206-vetdsk48 94 13 in in IN cord-295206-vetdsk48 94 14 general general JJ cord-295206-vetdsk48 94 15 . . . cord-295206-vetdsk48 95 1 The the DT cord-295206-vetdsk48 95 2 signs sign NNS cord-295206-vetdsk48 95 3 and and CC cord-295206-vetdsk48 95 4 symptoms symptom NNS cord-295206-vetdsk48 95 5 of of IN cord-295206-vetdsk48 95 6 acute acute JJ cord-295206-vetdsk48 95 7 bronchitis bronchitis NN cord-295206-vetdsk48 95 8 result result NN cord-295206-vetdsk48 95 9 from from IN cord-295206-vetdsk48 95 10 the the DT cord-295206-vetdsk48 95 11 pathogen pathogen NN cord-295206-vetdsk48 95 12 itself -PRON- PRP cord-295206-vetdsk48 95 13 and and CC cord-295206-vetdsk48 95 14 from from IN cord-295206-vetdsk48 95 15 the the DT cord-295206-vetdsk48 95 16 immune immune JJ cord-295206-vetdsk48 95 17 response response NN cord-295206-vetdsk48 95 18 to to IN cord-295206-vetdsk48 95 19 the the DT cord-295206-vetdsk48 95 20 infection infection NN cord-295206-vetdsk48 95 21 . . . cord-295206-vetdsk48 96 1 The the DT cord-295206-vetdsk48 96 2 acute acute JJ cord-295206-vetdsk48 96 3 phase phase NN cord-295206-vetdsk48 96 4 of of IN cord-295206-vetdsk48 96 5 this this DT cord-295206-vetdsk48 96 6 illness illness NN cord-295206-vetdsk48 96 7 lasts last VBZ cord-295206-vetdsk48 96 8 from from IN cord-295206-vetdsk48 96 9 1 1 CD cord-295206-vetdsk48 96 10 - - SYM cord-295206-vetdsk48 96 11 5 5 CD cord-295206-vetdsk48 96 12 days day NNS cord-295206-vetdsk48 96 13 and and CC cord-295206-vetdsk48 96 14 involves involve VBZ cord-295206-vetdsk48 96 15 constitutional constitutional JJ cord-295206-vetdsk48 96 16 symptoms symptom NNS cord-295206-vetdsk48 96 17 such such JJ cord-295206-vetdsk48 96 18 as as IN cord-295206-vetdsk48 96 19 fever fever NN cord-295206-vetdsk48 96 20 , , , cord-295206-vetdsk48 96 21 fatigue fatigue NN cord-295206-vetdsk48 96 22 , , , cord-295206-vetdsk48 96 23 and and CC cord-295206-vetdsk48 96 24 muscle muscle NN cord-295206-vetdsk48 96 25 aches ache NNS cord-295206-vetdsk48 96 26 Gonzales Gonzales NNP cord-295206-vetdsk48 96 27 and and CC cord-295206-vetdsk48 96 28 Sande Sande NNP cord-295206-vetdsk48 96 29 ( ( -LRB- cord-295206-vetdsk48 96 30 2000 2000 CD cord-295206-vetdsk48 96 31 ) ) -RRB- cord-295206-vetdsk48 96 32 , , , cord-295206-vetdsk48 96 33 Balter Balter NNP cord-295206-vetdsk48 96 34 ( ( -LRB- cord-295206-vetdsk48 96 35 2001 2001 CD cord-295206-vetdsk48 96 36 ) ) -RRB- cord-295206-vetdsk48 96 37 . . . cord-295206-vetdsk48 97 1 It -PRON- PRP cord-295206-vetdsk48 97 2 is be VBZ cord-295206-vetdsk48 97 3 during during IN cord-295206-vetdsk48 97 4 this this DT cord-295206-vetdsk48 97 5 phase phase NN cord-295206-vetdsk48 97 6 that that IN cord-295206-vetdsk48 97 7 viral viral JJ cord-295206-vetdsk48 97 8 colonization colonization NN cord-295206-vetdsk48 97 9 of of IN cord-295206-vetdsk48 97 10 the the DT cord-295206-vetdsk48 97 11 tracheobronchial tracheobronchial JJ cord-295206-vetdsk48 97 12 epithelium epithelium NN cord-295206-vetdsk48 97 13 occurs occur VBZ cord-295206-vetdsk48 97 14 . . . cord-295206-vetdsk48 98 1 In in IN cord-295206-vetdsk48 98 2 response response NN cord-295206-vetdsk48 98 3 to to IN cord-295206-vetdsk48 98 4 this this DT cord-295206-vetdsk48 98 5 infection infection NN cord-295206-vetdsk48 98 6 airway airway NN cord-295206-vetdsk48 98 7 epithelial epithelial JJ cord-295206-vetdsk48 98 8 cells cell NNS cord-295206-vetdsk48 98 9 and and CC cord-295206-vetdsk48 98 10 resident resident NN cord-295206-vetdsk48 98 11 monocytes monocyte NNS cord-295206-vetdsk48 98 12 and and CC cord-295206-vetdsk48 98 13 macrophages macrophage NNS cord-295206-vetdsk48 98 14 release release VBP cord-295206-vetdsk48 98 15 cytokines cytokine NNS cord-295206-vetdsk48 98 16 that that WDT cord-295206-vetdsk48 98 17 recruit recruit VBP cord-295206-vetdsk48 98 18 and and CC cord-295206-vetdsk48 98 19 activate activate VBP cord-295206-vetdsk48 98 20 immune immune JJ cord-295206-vetdsk48 98 21 cells cell NNS cord-295206-vetdsk48 98 22 . . . cord-295206-vetdsk48 99 1 Infection infection NN cord-295206-vetdsk48 99 2 with with IN cord-295206-vetdsk48 99 3 influenza influenza NN cord-295206-vetdsk48 99 4 A a DT cord-295206-vetdsk48 99 5 virus virus NN cord-295206-vetdsk48 99 6 provides provide VBZ cord-295206-vetdsk48 99 7 an an DT cord-295206-vetdsk48 99 8 example example NN cord-295206-vetdsk48 99 9 of of IN cord-295206-vetdsk48 99 10 this this DT cord-295206-vetdsk48 99 11 process process NN cord-295206-vetdsk48 99 12 . . . cord-295206-vetdsk48 100 1 Influenza influenza NN cord-295206-vetdsk48 101 1 A a DT cord-295206-vetdsk48 101 2 infection infection NN cord-295206-vetdsk48 101 3 stimulates stimulate VBZ cord-295206-vetdsk48 101 4 the the DT cord-295206-vetdsk48 101 5 release release NN cord-295206-vetdsk48 101 6 of of IN cord-295206-vetdsk48 101 7 chemotactic chemotactic JJ cord-295206-vetdsk48 101 8 chemokines chemokine NNS cord-295206-vetdsk48 101 9 including include VBG cord-295206-vetdsk48 101 10 RANTES RANTES NNP cord-295206-vetdsk48 101 11 , , , cord-295206-vetdsk48 101 12 monocyte monocyte NNP cord-295206-vetdsk48 101 13 chemotactic chemotactic VBD cord-295206-vetdsk48 101 14 protein-1 protein-1 NNP cord-295206-vetdsk48 101 15 ( ( -LRB- cord-295206-vetdsk48 101 16 MCP-1 MCP-1 NNP cord-295206-vetdsk48 101 17 ) ) -RRB- cord-295206-vetdsk48 101 18 , , , cord-295206-vetdsk48 101 19 and and CC cord-295206-vetdsk48 101 20 macrophage macrophage NN cord-295206-vetdsk48 101 21 inflammatory inflammatory JJ cord-295206-vetdsk48 101 22 protein-1alpha protein-1alpha NNS cord-295206-vetdsk48 101 23 ( ( -LRB- cord-295206-vetdsk48 101 24 MIP-1alpha MIP-1alpha NNP cord-295206-vetdsk48 101 25 ) ) -RRB- cord-295206-vetdsk48 101 26 , , , cord-295206-vetdsk48 101 27 pro pro JJ cord-295206-vetdsk48 101 28 - - JJ cord-295206-vetdsk48 101 29 inflammatory inflammatory JJ cord-295206-vetdsk48 101 30 cytokines cytokine NNS cord-295206-vetdsk48 101 31 such such JJ cord-295206-vetdsk48 101 32 as as IN cord-295206-vetdsk48 101 33 tumor tumor NN cord-295206-vetdsk48 101 34 necrosis necrosis NN cord-295206-vetdsk48 101 35 factor factor NN cord-295206-vetdsk48 101 36 - - HYPH cord-295206-vetdsk48 101 37 alpha alpha NN cord-295206-vetdsk48 101 38 ( ( -LRB- cord-295206-vetdsk48 101 39 TNF tnf NN cord-295206-vetdsk48 101 40 - - HYPH cord-295206-vetdsk48 101 41 alpha alpha NNP cord-295206-vetdsk48 101 42 ) ) -RRB- cord-295206-vetdsk48 101 43 , , , cord-295206-vetdsk48 101 44 interleukin-1beta interleukin-1beta NN cord-295206-vetdsk48 101 45 , , , cord-295206-vetdsk48 101 46 ( ( -LRB- cord-295206-vetdsk48 101 47 IL-1beta il-1beta NN cord-295206-vetdsk48 101 48 ) ) -RRB- cord-295206-vetdsk48 101 49 , , , cord-295206-vetdsk48 101 50 IL-6 IL-6 NNP cord-295206-vetdsk48 101 51 , , , cord-295206-vetdsk48 101 52 and and CC cord-295206-vetdsk48 101 53 IL-18 IL-18 NNP cord-295206-vetdsk48 101 54 , , , cord-295206-vetdsk48 101 55 and and CC cord-295206-vetdsk48 101 56 antiviral antiviral JJ cord-295206-vetdsk48 101 57 cytokines cytokine NNS cord-295206-vetdsk48 101 58 such such JJ cord-295206-vetdsk48 101 59 as as IN cord-295206-vetdsk48 101 60 interferon interferon NN cord-295206-vetdsk48 101 61 - - HYPH cord-295206-vetdsk48 101 62 alpha alpha NN cord-295206-vetdsk48 101 63 ( ( -LRB- cord-295206-vetdsk48 101 64 IFN IFN NNP cord-295206-vetdsk48 101 65 - - HYPH cord-295206-vetdsk48 101 66 alpha alpha NNP cord-295206-vetdsk48 101 67 ) ) -RRB- cord-295206-vetdsk48 101 68 and and CC cord-295206-vetdsk48 101 69 IFN IFN NNP cord-295206-vetdsk48 101 70 - - HYPH cord-295206-vetdsk48 101 71 betaJulkunen betaJulkunen NNP cord-295206-vetdsk48 101 72 et et FW cord-295206-vetdsk48 101 73 al al NNP cord-295206-vetdsk48 101 74 ( ( -LRB- cord-295206-vetdsk48 101 75 2001 2001 CD cord-295206-vetdsk48 101 76 ) ) -RRB- cord-295206-vetdsk48 101 77 . . . cord-295206-vetdsk48 102 1 Neutrophils neutrophil NNS cord-295206-vetdsk48 102 2 are be VBP cord-295206-vetdsk48 102 3 among among IN cord-295206-vetdsk48 102 4 the the DT cord-295206-vetdsk48 102 5 first first JJ cord-295206-vetdsk48 102 6 cells cell NNS cord-295206-vetdsk48 102 7 recruited recruit VBN cord-295206-vetdsk48 102 8 to to IN cord-295206-vetdsk48 102 9 the the DT cord-295206-vetdsk48 102 10 tracheobronchial tracheobronchial JJ cord-295206-vetdsk48 102 11 epithelium epithelium NN cord-295206-vetdsk48 102 12 , , , cord-295206-vetdsk48 102 13 and and CC cord-295206-vetdsk48 102 14 their -PRON- PRP$ cord-295206-vetdsk48 102 15 increased increase VBN cord-295206-vetdsk48 102 16 number number NN cord-295206-vetdsk48 102 17 correlates correlate VBZ cord-295206-vetdsk48 102 18 with with IN cord-295206-vetdsk48 102 19 the the DT cord-295206-vetdsk48 102 20 development development NN cord-295206-vetdsk48 102 21 of of IN cord-295206-vetdsk48 102 22 airway airway NNP cord-295206-vetdsk48 102 23 hyperresponsiveness hyperresponsiveness NNP cord-295206-vetdsk48 102 24 . . . cord-295206-vetdsk48 103 1 T T NNP cord-295206-vetdsk48 103 2 lymphocytes lymphocyte NNS cord-295206-vetdsk48 103 3 are be VBP cord-295206-vetdsk48 103 4 recruited recruit VBN cord-295206-vetdsk48 103 5 and and CC cord-295206-vetdsk48 103 6 activated activate VBN cord-295206-vetdsk48 103 7 by by IN cord-295206-vetdsk48 103 8 RANTES rante NNS cord-295206-vetdsk48 103 9 and and CC cord-295206-vetdsk48 103 10 other other JJ cord-295206-vetdsk48 103 11 cytokines cytokine NNS cord-295206-vetdsk48 103 12 released release VBN cord-295206-vetdsk48 103 13 by by IN cord-295206-vetdsk48 103 14 monocytes monocyte NNS cord-295206-vetdsk48 103 15 . . . cord-295206-vetdsk48 104 1 Eosinophils Eosinophils NNP cord-295206-vetdsk48 104 2 are be VBP cord-295206-vetdsk48 104 3 recruited recruit VBN cord-295206-vetdsk48 104 4 and and CC cord-295206-vetdsk48 104 5 activated activate VBN cord-295206-vetdsk48 104 6 and and CC cord-295206-vetdsk48 104 7 may may MD cord-295206-vetdsk48 104 8 persist persist VB cord-295206-vetdsk48 104 9 for for IN cord-295206-vetdsk48 104 10 weeks week NNS cord-295206-vetdsk48 104 11 after after IN cord-295206-vetdsk48 104 12 the the DT cord-295206-vetdsk48 104 13 initial initial JJ cord-295206-vetdsk48 104 14 infection infection NN cord-295206-vetdsk48 104 15 . . . cord-295206-vetdsk48 105 1 The the DT cord-295206-vetdsk48 105 2 protracted protracted JJ cord-295206-vetdsk48 105 3 phase phase NN cord-295206-vetdsk48 105 4 of of IN cord-295206-vetdsk48 105 5 acute acute JJ cord-295206-vetdsk48 105 6 bronchitis bronchitis NN cord-295206-vetdsk48 105 7 involves involve VBZ cord-295206-vetdsk48 105 8 coughing cough VBG cord-295206-vetdsk48 105 9 , , , cord-295206-vetdsk48 105 10 wheezing wheeze VBG cord-295206-vetdsk48 105 11 , , , cord-295206-vetdsk48 105 12 and and CC cord-295206-vetdsk48 105 13 sputum sputum NN cord-295206-vetdsk48 105 14 production production NN cord-295206-vetdsk48 105 15 and and CC cord-295206-vetdsk48 105 16 lasts last VBZ cord-295206-vetdsk48 105 17 from from IN cord-295206-vetdsk48 105 18 1 1 CD cord-295206-vetdsk48 105 19 - - SYM cord-295206-vetdsk48 105 20 3 3 CD cord-295206-vetdsk48 105 21 weeks week NNS cord-295206-vetdsk48 105 22 . . . cord-295206-vetdsk48 106 1 It -PRON- PRP cord-295206-vetdsk48 106 2 frequently frequently RB cord-295206-vetdsk48 106 3 involves involve VBZ cord-295206-vetdsk48 106 4 a a DT cord-295206-vetdsk48 106 5 significant significant JJ cord-295206-vetdsk48 106 6 decline decline NN cord-295206-vetdsk48 106 7 in in IN cord-295206-vetdsk48 106 8 pulmonary pulmonary JJ cord-295206-vetdsk48 106 9 function function NN cord-295206-vetdsk48 106 10 that that WDT cord-295206-vetdsk48 106 11 can can MD cord-295206-vetdsk48 106 12 be be VB cord-295206-vetdsk48 106 13 measured measure VBN cord-295206-vetdsk48 106 14 as as IN cord-295206-vetdsk48 106 15 a a DT cord-295206-vetdsk48 106 16 decrease decrease NN cord-295206-vetdsk48 106 17 in in IN cord-295206-vetdsk48 106 18 the the DT cord-295206-vetdsk48 106 19 forced force VBN cord-295206-vetdsk48 106 20 expiratory expiratory NNP cord-295206-vetdsk48 106 21 volume volume NNP cord-295206-vetdsk48 106 22 inn inn NNP cord-295206-vetdsk48 106 23 1 1 CD cord-295206-vetdsk48 106 24 second second NN cord-295206-vetdsk48 106 25 ( ( -LRB- cord-295206-vetdsk48 106 26 FEV FEV NNP cord-295206-vetdsk48 106 27 1 1 CD cord-295206-vetdsk48 106 28 ) ) -RRB- cord-295206-vetdsk48 106 29 . . . cord-295206-vetdsk48 107 1 The the DT cord-295206-vetdsk48 107 2 bronchial bronchial JJ cord-295206-vetdsk48 107 3 hyperresponsiveness hyperresponsiveness NN cord-295206-vetdsk48 107 4 , , , cord-295206-vetdsk48 107 5 which which WDT cord-295206-vetdsk48 107 6 was be VBD cord-295206-vetdsk48 107 7 initiated initiate VBN cord-295206-vetdsk48 107 8 during during IN cord-295206-vetdsk48 107 9 the the DT cord-295206-vetdsk48 107 10 acute acute JJ cord-295206-vetdsk48 107 11 phase phase NN cord-295206-vetdsk48 107 12 , , , cord-295206-vetdsk48 107 13 persists persist VBZ cord-295206-vetdsk48 107 14 for for IN cord-295206-vetdsk48 107 15 several several JJ cord-295206-vetdsk48 107 16 weeks week NNS cord-295206-vetdsk48 107 17 and and CC cord-295206-vetdsk48 107 18 correlates correlate VBZ cord-295206-vetdsk48 107 19 with with IN cord-295206-vetdsk48 107 20 the the DT cord-295206-vetdsk48 107 21 extended extended JJ cord-295206-vetdsk48 107 22 presence presence NN cord-295206-vetdsk48 107 23 and and CC cord-295206-vetdsk48 107 24 activation activation NN cord-295206-vetdsk48 107 25 of of IN cord-295206-vetdsk48 107 26 inflammatory inflammatory JJ cord-295206-vetdsk48 107 27 cells cell NNS cord-295206-vetdsk48 107 28 . . . cord-295206-vetdsk48 108 1 The the DT cord-295206-vetdsk48 108 2 pathological pathological JJ cord-295206-vetdsk48 108 3 hallmark hallmark NN cord-295206-vetdsk48 108 4 of of IN cord-295206-vetdsk48 108 5 chronic chronic JJ cord-295206-vetdsk48 108 6 bronchitis bronchitis NN cord-295206-vetdsk48 108 7 is be VBZ cord-295206-vetdsk48 108 8 airflow airflow NN cord-295206-vetdsk48 108 9 limitation limitation NN cord-295206-vetdsk48 108 10 secondary secondary JJ cord-295206-vetdsk48 108 11 to to IN cord-295206-vetdsk48 108 12 inflammation inflammation NN cord-295206-vetdsk48 108 13 and and CC cord-295206-vetdsk48 108 14 increased increase VBN cord-295206-vetdsk48 108 15 mucus mucus NN cord-295206-vetdsk48 108 16 production production NN cord-295206-vetdsk48 108 17 in in IN cord-295206-vetdsk48 108 18 the the DT cord-295206-vetdsk48 108 19 large large JJ cord-295206-vetdsk48 108 20 ( ( -LRB- cord-295206-vetdsk48 108 21 > > NFP cord-295206-vetdsk48 108 22 2 2 CD cord-295206-vetdsk48 108 23 mm mm NNP cord-295206-vetdsk48 108 24 ) ) -RRB- cord-295206-vetdsk48 108 25 airways airways NNPS cord-295206-vetdsk48 108 26 . . . cord-295206-vetdsk48 109 1 The the DT cord-295206-vetdsk48 109 2 disease disease NN cord-295206-vetdsk48 109 3 process process NN cord-295206-vetdsk48 109 4 begins begin VBZ cord-295206-vetdsk48 109 5 when when WRB cord-295206-vetdsk48 109 6 damage damage NN cord-295206-vetdsk48 109 7 to to IN cord-295206-vetdsk48 109 8 the the DT cord-295206-vetdsk48 109 9 airways airways NNP cord-295206-vetdsk48 109 10 initiates initiate VBZ cord-295206-vetdsk48 109 11 inflammation inflammation NN cord-295206-vetdsk48 109 12 and and CC cord-295206-vetdsk48 109 13 remodeling remodeling NN cord-295206-vetdsk48 109 14 of of IN cord-295206-vetdsk48 109 15 the the DT cord-295206-vetdsk48 109 16 airway airway NN cord-295206-vetdsk48 109 17 epithelium epithelium NN cord-295206-vetdsk48 109 18 , , , cord-295206-vetdsk48 109 19 leading lead VBG cord-295206-vetdsk48 109 20 to to IN cord-295206-vetdsk48 109 21 mucus mucus NN cord-295206-vetdsk48 109 22 hypersecretion hypersecretion NN cord-295206-vetdsk48 109 23 , , , cord-295206-vetdsk48 109 24 obstruction obstruction NN cord-295206-vetdsk48 109 25 of of IN cord-295206-vetdsk48 109 26 the the DT cord-295206-vetdsk48 109 27 airways airway NNS cord-295206-vetdsk48 109 28 , , , cord-295206-vetdsk48 109 29 and and CC cord-295206-vetdsk48 109 30 increased increase VBN cord-295206-vetdsk48 109 31 susceptibility susceptibility NN cord-295206-vetdsk48 109 32 to to IN cord-295206-vetdsk48 109 33 bacterial bacterial JJ cord-295206-vetdsk48 109 34 colonization colonization NN cord-295206-vetdsk48 109 35 MacNee MacNee NNP cord-295206-vetdsk48 109 36 ( ( -LRB- cord-295206-vetdsk48 109 37 2000 2000 CD cord-295206-vetdsk48 109 38 ) ) -RRB- cord-295206-vetdsk48 109 39 , , , cord-295206-vetdsk48 109 40 Turato Turato NNP cord-295206-vetdsk48 109 41 et et FW cord-295206-vetdsk48 109 42 al al NNP cord-295206-vetdsk48 109 43 ( ( -LRB- cord-295206-vetdsk48 109 44 2001 2001 CD cord-295206-vetdsk48 109 45 ) ) -RRB- cord-295206-vetdsk48 109 46 , , , cord-295206-vetdsk48 109 47 Cosio- Cosio- NNP cord-295206-vetdsk48 110 1 Piqueras Piqueras NNP cord-295206-vetdsk48 110 2 and and CC cord-295206-vetdsk48 110 3 Cosio Cosio NNP cord-295206-vetdsk48 110 4 ( ( -LRB- cord-295206-vetdsk48 110 5 2001 2001 CD cord-295206-vetdsk48 110 6 ) ) -RRB- cord-295206-vetdsk48 110 7 . . . cord-295206-vetdsk48 111 1 The the DT cord-295206-vetdsk48 111 2 presence presence NN cord-295206-vetdsk48 111 3 of of IN cord-295206-vetdsk48 111 4 pathogenic pathogenic JJ cord-295206-vetdsk48 111 5 bacteria bacteria NNS cord-295206-vetdsk48 111 6 in in IN cord-295206-vetdsk48 111 7 the the DT cord-295206-vetdsk48 111 8 lung lung NN cord-295206-vetdsk48 111 9 is be VBZ cord-295206-vetdsk48 111 10 a a DT cord-295206-vetdsk48 111 11 common common JJ cord-295206-vetdsk48 111 12 cause cause NN cord-295206-vetdsk48 111 13 of of IN cord-295206-vetdsk48 111 14 acute acute JJ cord-295206-vetdsk48 111 15 exacerbations exacerbation NNS cord-295206-vetdsk48 111 16 of of IN cord-295206-vetdsk48 111 17 chronic chronic JJ cord-295206-vetdsk48 111 18 bronchitis bronchitis NN cord-295206-vetdsk48 111 19 and and CC cord-295206-vetdsk48 111 20 may may MD cord-295206-vetdsk48 111 21 also also RB cord-295206-vetdsk48 111 22 be be VB cord-295206-vetdsk48 111 23 related relate VBN cord-295206-vetdsk48 111 24 to to IN cord-295206-vetdsk48 111 25 disease disease NN cord-295206-vetdsk48 111 26 progression progression NN cord-295206-vetdsk48 111 27 . . . cord-295206-vetdsk48 112 1 An an DT cord-295206-vetdsk48 112 2 ongoing ongoing JJ cord-295206-vetdsk48 112 3 cycle cycle NN cord-295206-vetdsk48 112 4 ensues ensue VBZ cord-295206-vetdsk48 112 5 in in IN cord-295206-vetdsk48 112 6 which which WDT cord-295206-vetdsk48 112 7 inflammation inflammation NN cord-295206-vetdsk48 112 8 and and CC cord-295206-vetdsk48 112 9 infection infection NN cord-295206-vetdsk48 112 10 produce produce VBP cord-295206-vetdsk48 112 11 further further JJ cord-295206-vetdsk48 112 12 epithelial epithelial JJ cord-295206-vetdsk48 112 13 damage damage NN cord-295206-vetdsk48 112 14 , , , cord-295206-vetdsk48 112 15 which which WDT cord-295206-vetdsk48 112 16 perpetuates perpetuate VBZ cord-295206-vetdsk48 112 17 additional additional JJ cord-295206-vetdsk48 112 18 inflammation inflammation NN cord-295206-vetdsk48 112 19 and and CC cord-295206-vetdsk48 112 20 airway airway NN cord-295206-vetdsk48 112 21 remodeling remodeling NN cord-295206-vetdsk48 112 22 . . . cord-295206-vetdsk48 113 1 Chronic chronic JJ cord-295206-vetdsk48 113 2 bronchitis bronchitis NN cord-295206-vetdsk48 113 3 is be VBZ cord-295206-vetdsk48 113 4 initiated initiate VBN cord-295206-vetdsk48 113 5 when when WRB cord-295206-vetdsk48 113 6 repeated repeat VBN cord-295206-vetdsk48 113 7 exposure exposure NN cord-295206-vetdsk48 113 8 to to IN cord-295206-vetdsk48 113 9 tobacco tobacco NN cord-295206-vetdsk48 113 10 smoke smoke NN cord-295206-vetdsk48 113 11 , , , cord-295206-vetdsk48 113 12 environmental environmental JJ cord-295206-vetdsk48 113 13 lung lung NN cord-295206-vetdsk48 113 14 irritants irritant NNS cord-295206-vetdsk48 113 15 ( ( -LRB- cord-295206-vetdsk48 113 16 e.g. e.g. RB cord-295206-vetdsk48 113 17 , , , cord-295206-vetdsk48 113 18 coal coal NN cord-295206-vetdsk48 113 19 or or CC cord-295206-vetdsk48 113 20 grain grain NN cord-295206-vetdsk48 113 21 dust dust NN cord-295206-vetdsk48 113 22 , , , cord-295206-vetdsk48 113 23 air air NN cord-295206-vetdsk48 113 24 pollutants pollutant NNS cord-295206-vetdsk48 113 25 ) ) -RRB- cord-295206-vetdsk48 113 26 , , , cord-295206-vetdsk48 113 27 and/or and/or CC cord-295206-vetdsk48 113 28 respiratory respiratory JJ cord-295206-vetdsk48 113 29 infections infection NNS cord-295206-vetdsk48 113 30 produce produce VBP cord-295206-vetdsk48 113 31 damage damage NN cord-295206-vetdsk48 113 32 in in IN cord-295206-vetdsk48 113 33 the the DT cord-295206-vetdsk48 113 34 large large JJ cord-295206-vetdsk48 113 35 airways airway NNS cord-295206-vetdsk48 113 36 . . . cord-295206-vetdsk48 114 1 Recruitment recruitment NN cord-295206-vetdsk48 114 2 of of IN cord-295206-vetdsk48 114 3 inflammatory inflammatory JJ cord-295206-vetdsk48 114 4 cells cell NNS cord-295206-vetdsk48 114 5 results result NNS cord-295206-vetdsk48 114 6 from from IN cord-295206-vetdsk48 114 7 upregulation upregulation NN cord-295206-vetdsk48 114 8 of of IN cord-295206-vetdsk48 114 9 adhesion adhesion NN cord-295206-vetdsk48 114 10 molecules molecule NNS cord-295206-vetdsk48 114 11 such such JJ cord-295206-vetdsk48 114 12 as as IN cord-295206-vetdsk48 114 13 ICAM-1 ICAM-1 NNP cord-295206-vetdsk48 114 14 and and CC cord-295206-vetdsk48 114 15 E E NNS cord-295206-vetdsk48 114 16 - - NN cord-295206-vetdsk48 114 17 selectin selectin NNS cord-295206-vetdsk48 114 18 on on IN cord-295206-vetdsk48 114 19 the the DT cord-295206-vetdsk48 114 20 subepithelial subepithelial JJ cord-295206-vetdsk48 114 21 blood blood NN cord-295206-vetdsk48 114 22 vessels vessel NNS cord-295206-vetdsk48 114 23 . . . cord-295206-vetdsk48 115 1 Neutrophils neutrophil NNS cord-295206-vetdsk48 115 2 are be VBP cord-295206-vetdsk48 115 3 the the DT cord-295206-vetdsk48 115 4 predominant predominant JJ cord-295206-vetdsk48 115 5 cell cell NN cord-295206-vetdsk48 115 6 type type NN cord-295206-vetdsk48 115 7 recruited recruit VBN cord-295206-vetdsk48 115 8 into into IN cord-295206-vetdsk48 115 9 the the DT cord-295206-vetdsk48 115 10 lumen lumen NN cord-295206-vetdsk48 115 11 of of IN cord-295206-vetdsk48 115 12 the the DT cord-295206-vetdsk48 115 13 airways airway NNS cord-295206-vetdsk48 115 14 . . . cord-295206-vetdsk48 116 1 Macrophages macrophage NNS cord-295206-vetdsk48 116 2 and and CC cord-295206-vetdsk48 116 3 CD8 CD8 NNP cord-295206-vetdsk48 116 4 + + CC cord-295206-vetdsk48 116 5 T T NNP cord-295206-vetdsk48 116 6 lymphocytes lymphocyte NNS cord-295206-vetdsk48 116 7 are be VBP cord-295206-vetdsk48 116 8 the the DT cord-295206-vetdsk48 116 9 predominant predominant JJ cord-295206-vetdsk48 116 10 cells cell NNS cord-295206-vetdsk48 116 11 that that WDT cord-295206-vetdsk48 116 12 infiltrate infiltrate VBP cord-295206-vetdsk48 116 13 the the DT cord-295206-vetdsk48 116 14 subepithelial subepithelial JJ cord-295206-vetdsk48 116 15 space space NN cord-295206-vetdsk48 116 16 . . . cord-295206-vetdsk48 117 1 Eosinophils Eosinophils NNP cord-295206-vetdsk48 117 2 are be VBP cord-295206-vetdsk48 117 3 prevalent prevalent JJ cord-295206-vetdsk48 117 4 in in IN cord-295206-vetdsk48 117 5 the the DT cord-295206-vetdsk48 117 6 subepithelium subepithelium NN cord-295206-vetdsk48 117 7 during during IN cord-295206-vetdsk48 117 8 acute acute JJ cord-295206-vetdsk48 117 9 exacerbations exacerbation NNS cord-295206-vetdsk48 117 10 of of IN cord-295206-vetdsk48 117 11 chronic chronic JJ cord-295206-vetdsk48 117 12 bronchitis bronchitis NN cord-295206-vetdsk48 117 13 , , , cord-295206-vetdsk48 117 14 while while IN cord-295206-vetdsk48 117 15 large large JJ cord-295206-vetdsk48 117 16 numbers number NNS cord-295206-vetdsk48 117 17 of of IN cord-295206-vetdsk48 117 18 neutrophils neutrophil NNS cord-295206-vetdsk48 117 19 are be VBP cord-295206-vetdsk48 117 20 seen see VBN cord-295206-vetdsk48 117 21 here here RB cord-295206-vetdsk48 117 22 only only RB cord-295206-vetdsk48 117 23 in in IN cord-295206-vetdsk48 117 24 severe severe JJ cord-295206-vetdsk48 117 25 disease disease NN cord-295206-vetdsk48 117 26 . . . cord-295206-vetdsk48 118 1 While while IN cord-295206-vetdsk48 118 2 enlargement enlargement NN cord-295206-vetdsk48 118 3 of of IN cord-295206-vetdsk48 118 4 the the DT cord-295206-vetdsk48 118 5 mucous mucous JJ cord-295206-vetdsk48 118 6 glands gland NNS cord-295206-vetdsk48 118 7 was be VBD cord-295206-vetdsk48 118 8 formerly formerly RB cord-295206-vetdsk48 118 9 believed believe VBN cord-295206-vetdsk48 118 10 to to IN cord-295206-vetdsk48 118 11 a a DT cord-295206-vetdsk48 118 12 defining defining JJ cord-295206-vetdsk48 118 13 feature feature NN cord-295206-vetdsk48 118 14 of of IN cord-295206-vetdsk48 118 15 chronic chronic JJ cord-295206-vetdsk48 118 16 bronchitis bronchitis NN cord-295206-vetdsk48 118 17 , , , cord-295206-vetdsk48 118 18 it -PRON- PRP cord-295206-vetdsk48 118 19 is be VBZ cord-295206-vetdsk48 118 20 now now RB cord-295206-vetdsk48 118 21 believed believe VBN cord-295206-vetdsk48 118 22 that that IN cord-295206-vetdsk48 118 23 inflammation inflammation NN cord-295206-vetdsk48 118 24 of of IN cord-295206-vetdsk48 118 25 these these DT cord-295206-vetdsk48 118 26 glands gland NNS cord-295206-vetdsk48 118 27 is be VBZ cord-295206-vetdsk48 118 28 more more RBR cord-295206-vetdsk48 118 29 characteristic characteristic JJ cord-295206-vetdsk48 118 30 . . . cord-295206-vetdsk48 119 1 Inflammatory inflammatory JJ cord-295206-vetdsk48 119 2 cells cell NNS cord-295206-vetdsk48 119 3 in in IN cord-295206-vetdsk48 119 4 the the DT cord-295206-vetdsk48 119 5 airway airway NN cord-295206-vetdsk48 119 6 lumen lumen NN cord-295206-vetdsk48 119 7 and and CC cord-295206-vetdsk48 119 8 epithelium epithelium NN cord-295206-vetdsk48 119 9 release release NN cord-295206-vetdsk48 119 10 mediators mediator NNS cord-295206-vetdsk48 119 11 that that WDT cord-295206-vetdsk48 119 12 control control VBP cord-295206-vetdsk48 119 13 the the DT cord-295206-vetdsk48 119 14 inflammation inflammation NN cord-295206-vetdsk48 119 15 and and CC cord-295206-vetdsk48 119 16 airway airway NN cord-295206-vetdsk48 119 17 remodeling remodeling NN cord-295206-vetdsk48 119 18 that that WDT cord-295206-vetdsk48 119 19 is be VBZ cord-295206-vetdsk48 119 20 characteristic characteristic JJ cord-295206-vetdsk48 119 21 of of IN cord-295206-vetdsk48 119 22 chronic chronic JJ cord-295206-vetdsk48 119 23 bronchitis bronchitis NN cord-295206-vetdsk48 119 24 Reid Reid NNP cord-295206-vetdsk48 119 25 and and CC cord-295206-vetdsk48 119 26 Sallenave Sallenave NNP cord-295206-vetdsk48 119 27 ( ( -LRB- cord-295206-vetdsk48 119 28 2003 2003 CD cord-295206-vetdsk48 119 29 ) ) -RRB- cord-295206-vetdsk48 119 30 . . . cord-295206-vetdsk48 120 1 Neutrophils neutrophils NN cord-295206-vetdsk48 120 2 release release VBP cord-295206-vetdsk48 120 3 reactive reactive JJ cord-295206-vetdsk48 120 4 oxygen oxygen NN cord-295206-vetdsk48 120 5 species specie NNS cord-295206-vetdsk48 120 6 such such JJ cord-295206-vetdsk48 120 7 as as IN cord-295206-vetdsk48 120 8 superoxide superoxide NN cord-295206-vetdsk48 120 9 and and CC cord-295206-vetdsk48 120 10 peroxynitrite peroxynitrite NN cord-295206-vetdsk48 120 11 that that WDT cord-295206-vetdsk48 120 12 produce produce VBP cord-295206-vetdsk48 120 13 tissue tissue NN cord-295206-vetdsk48 120 14 damage damage NN cord-295206-vetdsk48 120 15 and and CC cord-295206-vetdsk48 120 16 further further JJ cord-295206-vetdsk48 120 17 inflammation inflammation NN cord-295206-vetdsk48 120 18 . . . cord-295206-vetdsk48 121 1 Elevated elevated JJ cord-295206-vetdsk48 121 2 levels level NNS cord-295206-vetdsk48 121 3 of of IN cord-295206-vetdsk48 121 4 pro pro JJ cord-295206-vetdsk48 121 5 - - JJ cord-295206-vetdsk48 121 6 inflammatory inflammatory JJ cord-295206-vetdsk48 121 7 molecules molecule NNS cord-295206-vetdsk48 121 8 , , , cord-295206-vetdsk48 121 9 such such JJ cord-295206-vetdsk48 121 10 as as IN cord-295206-vetdsk48 121 11 IL-8 IL-8 NNP cord-295206-vetdsk48 121 12 , , , cord-295206-vetdsk48 121 13 LTB LTB NNP cord-295206-vetdsk48 121 14 4 4 CD cord-295206-vetdsk48 121 15 , , , cord-295206-vetdsk48 121 16 and and CC cord-295206-vetdsk48 121 17 TNF tnf NN cord-295206-vetdsk48 121 18 - - HYPH cord-295206-vetdsk48 121 19 alpha alpha NN cord-295206-vetdsk48 121 20 , , , cord-295206-vetdsk48 121 21 and and CC cord-295206-vetdsk48 121 22 diminished diminished JJ cord-295206-vetdsk48 121 23 levels level NNS cord-295206-vetdsk48 121 24 of of IN cord-295206-vetdsk48 121 25 the the DT cord-295206-vetdsk48 121 26 anti anti JJ cord-295206-vetdsk48 121 27 - - JJ cord-295206-vetdsk48 121 28 inflammatory inflammatory JJ cord-295206-vetdsk48 121 29 cytokine cytokine NN cord-295206-vetdsk48 121 30 IL-10 IL-10 NNP cord-295206-vetdsk48 121 31 are be VBP cord-295206-vetdsk48 121 32 seen see VBN cord-295206-vetdsk48 121 33 in in IN cord-295206-vetdsk48 121 34 the the DT cord-295206-vetdsk48 121 35 sputum sputum NN cord-295206-vetdsk48 121 36 of of IN cord-295206-vetdsk48 121 37 individuals individual NNS cord-295206-vetdsk48 121 38 with with IN cord-295206-vetdsk48 121 39 chronic chronic JJ cord-295206-vetdsk48 121 40 bronchitis bronchitis NN cord-295206-vetdsk48 121 41 . . . cord-295206-vetdsk48 122 1 Elevated elevated JJ cord-295206-vetdsk48 122 2 levels level NNS cord-295206-vetdsk48 122 3 of of IN cord-295206-vetdsk48 122 4 the the DT cord-295206-vetdsk48 122 5 mucus mucus NN cord-295206-vetdsk48 122 6 - - HYPH cord-295206-vetdsk48 122 7 stimulating stimulate VBG cord-295206-vetdsk48 122 8 cytokines cytokine NNS cord-295206-vetdsk48 122 9 IL-4 IL-4 NNP cord-295206-vetdsk48 122 10 and and CC cord-295206-vetdsk48 122 11 IL-13 IL-13 NNP cord-295206-vetdsk48 122 12 are be VBP cord-295206-vetdsk48 122 13 seen see VBN cord-295206-vetdsk48 122 14 in in IN cord-295206-vetdsk48 122 15 patients patient NNS cord-295206-vetdsk48 122 16 with with IN cord-295206-vetdsk48 122 17 chronic chronic JJ cord-295206-vetdsk48 122 18 bronchitis bronchitis NN cord-295206-vetdsk48 122 19 . . . cord-295206-vetdsk48 123 1 Neutrophils neutrophils NN cord-295206-vetdsk48 123 2 in in IN cord-295206-vetdsk48 123 3 the the DT cord-295206-vetdsk48 123 4 airways airways NNP cord-295206-vetdsk48 123 5 release release NN cord-295206-vetdsk48 123 6 neutrophil neutrophil NN cord-295206-vetdsk48 123 7 elastase elastase NN cord-295206-vetdsk48 123 8 , , , cord-295206-vetdsk48 123 9 a a DT cord-295206-vetdsk48 123 10 serine serine NN cord-295206-vetdsk48 123 11 protease protease NN cord-295206-vetdsk48 123 12 that that WDT cord-295206-vetdsk48 123 13 increases increase VBZ cord-295206-vetdsk48 123 14 the the DT cord-295206-vetdsk48 123 15 production production NN cord-295206-vetdsk48 123 16 of of IN cord-295206-vetdsk48 123 17 mucus mucus NN cord-295206-vetdsk48 123 18 and and CC cord-295206-vetdsk48 123 19 stimulates stimulate VBZ cord-295206-vetdsk48 123 20 the the DT cord-295206-vetdsk48 123 21 proliferation proliferation NN cord-295206-vetdsk48 123 22 of of IN cord-295206-vetdsk48 123 23 mucus mucus NN cord-295206-vetdsk48 123 24 - - HYPH cord-295206-vetdsk48 123 25 producing produce VBG cord-295206-vetdsk48 123 26 goblet goblet NN cord-295206-vetdsk48 123 27 cells cell NNS cord-295206-vetdsk48 123 28 . . . cord-295206-vetdsk48 124 1 Squamous squamous JJ cord-295206-vetdsk48 124 2 metaplasia metaplasia NN cord-295206-vetdsk48 124 3 occurs occur VBZ cord-295206-vetdsk48 124 4 , , , cord-295206-vetdsk48 124 5 resulting result VBG cord-295206-vetdsk48 124 6 in in IN cord-295206-vetdsk48 124 7 the the DT cord-295206-vetdsk48 124 8 replacement replacement NN cord-295206-vetdsk48 124 9 of of IN cord-295206-vetdsk48 124 10 many many JJ cord-295206-vetdsk48 124 11 ciliated ciliated JJ cord-295206-vetdsk48 124 12 columnar columnar JJ cord-295206-vetdsk48 124 13 epithelial epithelial JJ cord-295206-vetdsk48 124 14 cells cell NNS cord-295206-vetdsk48 124 15 with with IN cord-295206-vetdsk48 124 16 squamous squamous JJ cord-295206-vetdsk48 124 17 epithelial epithelial JJ cord-295206-vetdsk48 124 18 cells cell NNS cord-295206-vetdsk48 124 19 . . . cord-295206-vetdsk48 125 1 Overall overall RB cord-295206-vetdsk48 125 2 , , , cord-295206-vetdsk48 125 3 these these DT cord-295206-vetdsk48 125 4 processes process NNS cord-295206-vetdsk48 125 5 of of IN cord-295206-vetdsk48 125 6 excessive excessive JJ cord-295206-vetdsk48 125 7 bronchial bronchial JJ cord-295206-vetdsk48 125 8 mucus mucus NN cord-295206-vetdsk48 125 9 secretion secretion NN cord-295206-vetdsk48 125 10 and and CC cord-295206-vetdsk48 125 11 impaired impaired JJ cord-295206-vetdsk48 125 12 clearance clearance NN cord-295206-vetdsk48 125 13 result result NN cord-295206-vetdsk48 125 14 in in IN cord-295206-vetdsk48 125 15 airway airway NN cord-295206-vetdsk48 125 16 obstruction obstruction NN cord-295206-vetdsk48 125 17 , , , cord-295206-vetdsk48 125 18 irritation irritation NN cord-295206-vetdsk48 125 19 , , , cord-295206-vetdsk48 125 20 and and CC cord-295206-vetdsk48 125 21 an an DT cord-295206-vetdsk48 125 22 increased increase VBN cord-295206-vetdsk48 125 23 likelihood likelihood NN cord-295206-vetdsk48 125 24 of of IN cord-295206-vetdsk48 125 25 infection infection NN cord-295206-vetdsk48 125 26 . . . cord-295206-vetdsk48 126 1 Many many JJ cord-295206-vetdsk48 126 2 similarities similarity NNS cord-295206-vetdsk48 126 3 exist exist VBP cord-295206-vetdsk48 126 4 between between IN cord-295206-vetdsk48 126 5 the the DT cord-295206-vetdsk48 126 6 processes process NNS cord-295206-vetdsk48 126 7 occurring occur VBG cord-295206-vetdsk48 126 8 in in IN cord-295206-vetdsk48 126 9 the the DT cord-295206-vetdsk48 126 10 large large JJ cord-295206-vetdsk48 126 11 and and CC cord-295206-vetdsk48 126 12 small small JJ cord-295206-vetdsk48 126 13 ( ( -LRB- cord-295206-vetdsk48 126 14 < < NNP cord-295206-vetdsk48 126 15 2 2 CD cord-295206-vetdsk48 126 16 mm mm NNP cord-295206-vetdsk48 126 17 ) ) -RRB- cord-295206-vetdsk48 126 18 airways airways NNPS cord-295206-vetdsk48 126 19 of of IN cord-295206-vetdsk48 126 20 those those DT cord-295206-vetdsk48 126 21 with with IN cord-295206-vetdsk48 126 22 chronic chronic JJ cord-295206-vetdsk48 126 23 bronchitis bronchitis NN cord-295206-vetdsk48 126 24 . . . cord-295206-vetdsk48 127 1 Subepithelial subepithelial JJ cord-295206-vetdsk48 127 2 infiltration infiltration NN cord-295206-vetdsk48 127 3 of of IN cord-295206-vetdsk48 127 4 CD8 CD8 NNP cord-295206-vetdsk48 127 5 + + CC cord-295206-vetdsk48 127 6 T T NNP cord-295206-vetdsk48 127 7 lymphocytes lymphocyte NNS cord-295206-vetdsk48 127 8 and and CC cord-295206-vetdsk48 127 9 goblet goblet NN cord-295206-vetdsk48 127 10 cell cell NN cord-295206-vetdsk48 127 11 proliferation proliferation NN cord-295206-vetdsk48 127 12 contribute contribute VBP cord-295206-vetdsk48 127 13 to to IN cord-295206-vetdsk48 127 14 inflammation inflammation NN cord-295206-vetdsk48 127 15 and and CC cord-295206-vetdsk48 127 16 mucus mucus NN cord-295206-vetdsk48 127 17 secretion secretion NN cord-295206-vetdsk48 127 18 , , , cord-295206-vetdsk48 127 19 respectively respectively RB cord-295206-vetdsk48 127 20 . . . cord-295206-vetdsk48 128 1 In in IN cord-295206-vetdsk48 128 2 addition addition NN cord-295206-vetdsk48 128 3 , , , cord-295206-vetdsk48 128 4 fibrosis fibrosis NN cord-295206-vetdsk48 128 5 of of IN cord-295206-vetdsk48 128 6 the the DT cord-295206-vetdsk48 128 7 airway airway NN cord-295206-vetdsk48 128 8 walls wall NNS cord-295206-vetdsk48 128 9 decreases decrease VBZ cord-295206-vetdsk48 128 10 the the DT cord-295206-vetdsk48 128 11 elastic elastic JJ cord-295206-vetdsk48 128 12 recoil recoil NN cord-295206-vetdsk48 128 13 of of IN cord-295206-vetdsk48 128 14 the the DT cord-295206-vetdsk48 128 15 lung lung NN cord-295206-vetdsk48 128 16 , , , cord-295206-vetdsk48 128 17 while while IN cord-295206-vetdsk48 128 18 hypertrophy hypertrophy NN cord-295206-vetdsk48 128 19 of of IN cord-295206-vetdsk48 128 20 the the DT cord-295206-vetdsk48 128 21 bronchiolar bronchiolar JJ cord-295206-vetdsk48 128 22 smooth smooth JJ cord-295206-vetdsk48 128 23 muscle muscle NN cord-295206-vetdsk48 128 24 produces produce VBZ cord-295206-vetdsk48 128 25 airflow airflow NN cord-295206-vetdsk48 128 26 restriction restriction NN cord-295206-vetdsk48 128 27 . . . cord-295206-vetdsk48 129 1 Attachments attachment NNS cord-295206-vetdsk48 129 2 of of IN cord-295206-vetdsk48 129 3 the the DT cord-295206-vetdsk48 129 4 alveoli alveolus NNS cord-295206-vetdsk48 129 5 to to IN cord-295206-vetdsk48 129 6 the the DT cord-295206-vetdsk48 129 7 bronchioles bronchiole NNS cord-295206-vetdsk48 129 8 may may MD cord-295206-vetdsk48 129 9 be be VB cord-295206-vetdsk48 129 10 lost lose VBN cord-295206-vetdsk48 129 11 as as RB cord-295206-vetdsk48 129 12 well well RB cord-295206-vetdsk48 129 13 . . . cord-295206-vetdsk48 130 1 In in IN cord-295206-vetdsk48 130 2 the the DT cord-295206-vetdsk48 130 3 pulmonary pulmonary JJ cord-295206-vetdsk48 130 4 arteries artery NNS cord-295206-vetdsk48 130 5 , , , cord-295206-vetdsk48 130 6 chronic chronic JJ cord-295206-vetdsk48 130 7 bronchitis bronchitis NN cord-295206-vetdsk48 130 8 causes cause VBZ cord-295206-vetdsk48 130 9 proliferation proliferation NN cord-295206-vetdsk48 130 10 of of IN cord-295206-vetdsk48 130 11 smooth smooth JJ cord-295206-vetdsk48 130 12 muscle muscle NN cord-295206-vetdsk48 130 13 cells cell NNS cord-295206-vetdsk48 130 14 and and CC cord-295206-vetdsk48 130 15 deposition deposition NN cord-295206-vetdsk48 130 16 of of IN cord-295206-vetdsk48 130 17 elastic elastic JJ cord-295206-vetdsk48 130 18 and and CC cord-295206-vetdsk48 130 19 collagen collagen NN cord-295206-vetdsk48 130 20 fibers fiber NNS cord-295206-vetdsk48 130 21 Turato Turato NNP cord-295206-vetdsk48 130 22 et et FW cord-295206-vetdsk48 130 23 al al NNP cord-295206-vetdsk48 130 24 ( ( -LRB- cord-295206-vetdsk48 130 25 2001 2001 CD cord-295206-vetdsk48 130 26 ) ) -RRB- cord-295206-vetdsk48 130 27 . . . cord-295206-vetdsk48 131 1 This this DT cord-295206-vetdsk48 131 2 appears appear VBZ cord-295206-vetdsk48 131 3 to to TO cord-295206-vetdsk48 131 4 be be VB cord-295206-vetdsk48 131 5 the the DT cord-295206-vetdsk48 131 6 result result NN cord-295206-vetdsk48 131 7 of of IN cord-295206-vetdsk48 131 8 endothelial endothelial JJ cord-295206-vetdsk48 131 9 dysfunction dysfunction NN cord-295206-vetdsk48 131 10 that that WDT cord-295206-vetdsk48 131 11 results result VBZ cord-295206-vetdsk48 131 12 from from IN cord-295206-vetdsk48 131 13 hypoxemia hypoxemia NN cord-295206-vetdsk48 131 14 or or CC cord-295206-vetdsk48 131 15 other other JJ cord-295206-vetdsk48 131 16 , , , cord-295206-vetdsk48 131 17 unknown unknown JJ cord-295206-vetdsk48 131 18 factors factor NNS cord-295206-vetdsk48 131 19 . . . cord-295206-vetdsk48 132 1 Pulmonary pulmonary JJ cord-295206-vetdsk48 132 2 hypertension hypertension NN cord-295206-vetdsk48 132 3 occurs occur VBZ cord-295206-vetdsk48 132 4 as as IN cord-295206-vetdsk48 132 5 a a DT cord-295206-vetdsk48 132 6 consequence consequence NN cord-295206-vetdsk48 132 7 of of IN cord-295206-vetdsk48 132 8 pulmonary pulmonary JJ cord-295206-vetdsk48 132 9 artery artery NN cord-295206-vetdsk48 132 10 narrowing narrowing NN cord-295206-vetdsk48 132 11 , , , cord-295206-vetdsk48 132 12 and and CC cord-295206-vetdsk48 132 13 the the DT cord-295206-vetdsk48 132 14 right right JJ cord-295206-vetdsk48 132 15 ventricle ventricle NN cord-295206-vetdsk48 132 16 may may MD cord-295206-vetdsk48 132 17 become become VB cord-295206-vetdsk48 132 18 enlarged enlarged JJ cord-295206-vetdsk48 132 19 as as IN cord-295206-vetdsk48 132 20 a a DT cord-295206-vetdsk48 132 21 result result NN cord-295206-vetdsk48 132 22 of of IN cord-295206-vetdsk48 132 23 prolonged prolonged JJ cord-295206-vetdsk48 132 24 pumping pumping NN cord-295206-vetdsk48 132 25 against against IN cord-295206-vetdsk48 132 26 elevated elevated JJ cord-295206-vetdsk48 132 27 arterial arterial JJ cord-295206-vetdsk48 132 28 pressure pressure NN cord-295206-vetdsk48 132 29 . . . cord-295206-vetdsk48 133 1 Right right JJ cord-295206-vetdsk48 133 2 ventricular ventricular JJ cord-295206-vetdsk48 133 3 failure failure NN cord-295206-vetdsk48 133 4 ( ( -LRB- cord-295206-vetdsk48 133 5 cor cor NNP cord-295206-vetdsk48 133 6 pulmonale pulmonale NNP cord-295206-vetdsk48 133 7 ) ) -RRB- cord-295206-vetdsk48 133 8 is be VBZ cord-295206-vetdsk48 133 9 a a DT cord-295206-vetdsk48 133 10 common common JJ cord-295206-vetdsk48 133 11 complication complication NN cord-295206-vetdsk48 133 12 of of IN cord-295206-vetdsk48 133 13 chronic chronic JJ cord-295206-vetdsk48 133 14 bronchitis bronchitis NN cord-295206-vetdsk48 133 15 . . . cord-295206-vetdsk48 134 1 The the DT cord-295206-vetdsk48 134 2 initial initial JJ cord-295206-vetdsk48 134 3 , , , cord-295206-vetdsk48 134 4 acute acute JJ cord-295206-vetdsk48 134 5 phase phase NN cord-295206-vetdsk48 134 6 of of IN cord-295206-vetdsk48 134 7 acute acute JJ cord-295206-vetdsk48 134 8 bronchitis bronchitis NN cord-295206-vetdsk48 134 9 begins begin VBZ cord-295206-vetdsk48 134 10 with with IN cord-295206-vetdsk48 134 11 1 1 CD cord-295206-vetdsk48 134 12 - - SYM cord-295206-vetdsk48 134 13 5 5 CD cord-295206-vetdsk48 134 14 days day NNS cord-295206-vetdsk48 134 15 of of IN cord-295206-vetdsk48 134 16 constitutional constitutional JJ cord-295206-vetdsk48 134 17 symptoms symptom NNS cord-295206-vetdsk48 134 18 such such JJ cord-295206-vetdsk48 134 19 as as IN cord-295206-vetdsk48 134 20 fever fever NN cord-295206-vetdsk48 134 21 , , , cord-295206-vetdsk48 134 22 malaise malaise NN cord-295206-vetdsk48 134 23 , , , cord-295206-vetdsk48 134 24 and and CC cord-295206-vetdsk48 134 25 muscle muscle NN cord-295206-vetdsk48 134 26 aches ache NNS cord-295206-vetdsk48 134 27 Gonzales Gonzales NNP cord-295206-vetdsk48 134 28 and and CC cord-295206-vetdsk48 134 29 Sande Sande NNP cord-295206-vetdsk48 134 30 ( ( -LRB- cord-295206-vetdsk48 134 31 2000 2000 CD cord-295206-vetdsk48 134 32 ) ) -RRB- cord-295206-vetdsk48 134 33 . . . cord-295206-vetdsk48 135 1 These these DT cord-295206-vetdsk48 135 2 symptoms symptom NNS cord-295206-vetdsk48 135 3 are be VBP cord-295206-vetdsk48 135 4 variable variable JJ cord-295206-vetdsk48 135 5 in in IN cord-295206-vetdsk48 135 6 extent extent NN cord-295206-vetdsk48 135 7 and and CC cord-295206-vetdsk48 135 8 duration duration NN cord-295206-vetdsk48 135 9 , , , cord-295206-vetdsk48 135 10 and and CC cord-295206-vetdsk48 135 11 depend depend VB cord-295206-vetdsk48 135 12 upon upon IN cord-295206-vetdsk48 135 13 the the DT cord-295206-vetdsk48 135 14 nature nature NN cord-295206-vetdsk48 135 15 of of IN cord-295206-vetdsk48 135 16 the the DT cord-295206-vetdsk48 135 17 infectious infectious JJ cord-295206-vetdsk48 135 18 agent agent NN cord-295206-vetdsk48 135 19 . . . cord-295206-vetdsk48 136 1 For for IN cord-295206-vetdsk48 136 2 example example NN cord-295206-vetdsk48 136 3 , , , cord-295206-vetdsk48 136 4 rhinovirus rhinovirus NN cord-295206-vetdsk48 136 5 infection infection NN cord-295206-vetdsk48 136 6 produces produce VBZ cord-295206-vetdsk48 136 7 minimal minimal JJ cord-295206-vetdsk48 136 8 or or CC cord-295206-vetdsk48 136 9 no no DT cord-295206-vetdsk48 136 10 constitutional constitutional JJ cord-295206-vetdsk48 136 11 symptoms symptom NNS cord-295206-vetdsk48 136 12 whereas whereas IN cord-295206-vetdsk48 136 13 influenza influenza NN cord-295206-vetdsk48 136 14 and and CC cord-295206-vetdsk48 136 15 parainfluenza parainfluenza NNP cord-295206-vetdsk48 136 16 produce produce VBP cord-295206-vetdsk48 136 17 the the DT cord-295206-vetdsk48 136 18 most most RBS cord-295206-vetdsk48 136 19 severe severe JJ cord-295206-vetdsk48 136 20 and and CC cord-295206-vetdsk48 136 21 prolonged prolonged JJ cord-295206-vetdsk48 136 22 symptoms symptom NNS cord-295206-vetdsk48 136 23 . . . cord-295206-vetdsk48 137 1 The the DT cord-295206-vetdsk48 137 2 protracted protracted JJ cord-295206-vetdsk48 137 3 phase phase NN cord-295206-vetdsk48 137 4 of of IN cord-295206-vetdsk48 137 5 acute acute JJ cord-295206-vetdsk48 137 6 bronchitis bronchitis NN cord-295206-vetdsk48 137 7 lasts last VBZ cord-295206-vetdsk48 137 8 for for IN cord-295206-vetdsk48 137 9 1 1 CD cord-295206-vetdsk48 137 10 - - SYM cord-295206-vetdsk48 137 11 3 3 CD cord-295206-vetdsk48 137 12 weeks week NNS cord-295206-vetdsk48 137 13 and and CC cord-295206-vetdsk48 137 14 involves involve VBZ cord-295206-vetdsk48 137 15 coughing cough VBG cord-295206-vetdsk48 137 16 , , , cord-295206-vetdsk48 137 17 increased increase VBN cord-295206-vetdsk48 137 18 sputum sputum NN cord-295206-vetdsk48 137 19 production production NN cord-295206-vetdsk48 137 20 , , , cord-295206-vetdsk48 137 21 and and CC cord-295206-vetdsk48 137 22 wheezing wheezing NN cord-295206-vetdsk48 137 23 . . . cord-295206-vetdsk48 138 1 Acute acute JJ cord-295206-vetdsk48 138 2 bronchitis bronchitis NN cord-295206-vetdsk48 138 3 is be VBZ cord-295206-vetdsk48 138 4 distinguished distinguish VBN cord-295206-vetdsk48 138 5 from from IN cord-295206-vetdsk48 138 6 upper upper JJ cord-295206-vetdsk48 138 7 respiratory respiratory JJ cord-295206-vetdsk48 138 8 infections infection NNS cord-295206-vetdsk48 138 9 by by IN cord-295206-vetdsk48 138 10 the the DT cord-295206-vetdsk48 138 11 presence presence NN cord-295206-vetdsk48 138 12 of of IN cord-295206-vetdsk48 138 13 cough cough NN cord-295206-vetdsk48 138 14 , , , cord-295206-vetdsk48 138 15 sputum sputum NN cord-295206-vetdsk48 138 16 , , , cord-295206-vetdsk48 138 17 and and CC cord-295206-vetdsk48 138 18 wheezing wheeze VBG cord-295206-vetdsk48 138 19 with with IN cord-295206-vetdsk48 138 20 the the DT cord-295206-vetdsk48 138 21 former former JJ cord-295206-vetdsk48 138 22 . . . cord-295206-vetdsk48 139 1 The the DT cord-295206-vetdsk48 139 2 signs sign NNS cord-295206-vetdsk48 139 3 and and CC cord-295206-vetdsk48 139 4 symptoms symptom NNS cord-295206-vetdsk48 139 5 of of IN cord-295206-vetdsk48 139 6 acute acute JJ cord-295206-vetdsk48 139 7 bronchitis bronchitis NN cord-295206-vetdsk48 139 8 differ differ VBP cord-295206-vetdsk48 139 9 from from IN cord-295206-vetdsk48 139 10 those those DT cord-295206-vetdsk48 139 11 of of IN cord-295206-vetdsk48 139 12 pneumonia pneumonia NN cord-295206-vetdsk48 139 13 in in IN cord-295206-vetdsk48 139 14 that that DT cord-295206-vetdsk48 139 15 pneumonia pneumonia NN cord-295206-vetdsk48 140 1 causes cause VBZ cord-295206-vetdsk48 140 2 abnormal abnormal JJ cord-295206-vetdsk48 140 3 lung lung NN cord-295206-vetdsk48 140 4 sounds sound NNS cord-295206-vetdsk48 140 5 that that WDT cord-295206-vetdsk48 140 6 indicate indicate VBP cord-295206-vetdsk48 140 7 the the DT cord-295206-vetdsk48 140 8 presence presence NN cord-295206-vetdsk48 140 9 of of IN cord-295206-vetdsk48 140 10 fluid fluid NN cord-295206-vetdsk48 140 11 ( ( -LRB- cord-295206-vetdsk48 140 12 e.g. e.g. RB cord-295206-vetdsk48 140 13 , , , cord-295206-vetdsk48 140 14 rales rale NNS cord-295206-vetdsk48 140 15 ) ) -RRB- cord-295206-vetdsk48 140 16 and and CC cord-295206-vetdsk48 140 17 elevations elevation NNS cord-295206-vetdsk48 140 18 in in IN cord-295206-vetdsk48 140 19 vital vital JJ cord-295206-vetdsk48 140 20 signs sign NNS cord-295206-vetdsk48 140 21 ( ( -LRB- cord-295206-vetdsk48 140 22 heart heart NN cord-295206-vetdsk48 140 23 rate rate NN cord-295206-vetdsk48 140 24 > > XX cord-295206-vetdsk48 140 25 100 100 CD cord-295206-vetdsk48 140 26 beats beat NNS cord-295206-vetdsk48 140 27 / / SYM cord-295206-vetdsk48 140 28 minute minute NN cord-295206-vetdsk48 140 29 , , , cord-295206-vetdsk48 140 30 respiratory respiratory JJ cord-295206-vetdsk48 140 31 rate rate NN cord-295206-vetdsk48 140 32 > > XX cord-295206-vetdsk48 140 33 24 24 CD cord-295206-vetdsk48 140 34 breaths breath NNS cord-295206-vetdsk48 140 35 / / SYM cord-295206-vetdsk48 140 36 minute minute NN cord-295206-vetdsk48 140 37 , , , cord-295206-vetdsk48 140 38 and and CC cord-295206-vetdsk48 140 39 temperature temperature NN cord-295206-vetdsk48 140 40 > > XX cord-295206-vetdsk48 140 41 38 38 CD cord-295206-vetdsk48 140 42 C C NNP cord-295206-vetdsk48 140 43 ) ) -RRB- cord-295206-vetdsk48 140 44 . . . cord-295206-vetdsk48 141 1 While while IN cord-295206-vetdsk48 141 2 pneumonia pneumonia NN cord-295206-vetdsk48 141 3 can can MD cord-295206-vetdsk48 141 4 be be VB cord-295206-vetdsk48 141 5 confirmed confirm VBN cord-295206-vetdsk48 141 6 with with IN cord-295206-vetdsk48 141 7 radiography radiography NN cord-295206-vetdsk48 141 8 , , , cord-295206-vetdsk48 141 9 this this DT cord-295206-vetdsk48 141 10 is be VBZ cord-295206-vetdsk48 141 11 unwarranted unwarranted JJ cord-295206-vetdsk48 141 12 in in IN cord-295206-vetdsk48 141 13 low low JJ cord-295206-vetdsk48 141 14 - - HYPH cord-295206-vetdsk48 141 15 risk risk NN cord-295206-vetdsk48 141 16 individuals individual NNS cord-295206-vetdsk48 141 17 who who WP cord-295206-vetdsk48 141 18 have have VBP cord-295206-vetdsk48 141 19 elevated elevate VBN cord-295206-vetdsk48 141 20 vital vital JJ cord-295206-vetdsk48 141 21 signs sign NNS cord-295206-vetdsk48 141 22 without without IN cord-295206-vetdsk48 141 23 abnormal abnormal JJ cord-295206-vetdsk48 141 24 lung lung NN cord-295206-vetdsk48 141 25 sounds sound NNS cord-295206-vetdsk48 141 26 , , , cord-295206-vetdsk48 141 27 particularly particularly RB cord-295206-vetdsk48 141 28 during during IN cord-295206-vetdsk48 141 29 a a DT cord-295206-vetdsk48 141 30 known know VBN cord-295206-vetdsk48 141 31 viral viral JJ cord-295206-vetdsk48 141 32 outbreak outbreak NN cord-295206-vetdsk48 141 33 . . . cord-295206-vetdsk48 142 1 X x NN cord-295206-vetdsk48 142 2 - - NN cord-295206-vetdsk48 142 3 ray ray JJ cord-295206-vetdsk48 142 4 testing testing NN cord-295206-vetdsk48 142 5 in in IN cord-295206-vetdsk48 142 6 the the DT cord-295206-vetdsk48 142 7 absence absence NN cord-295206-vetdsk48 142 8 of of IN cord-295206-vetdsk48 142 9 abnormal abnormal JJ cord-295206-vetdsk48 142 10 lung lung NN cord-295206-vetdsk48 142 11 sounds sound NNS cord-295206-vetdsk48 142 12 may may MD cord-295206-vetdsk48 142 13 be be VB cord-295206-vetdsk48 142 14 necessary necessary JJ cord-295206-vetdsk48 142 15 in in IN cord-295206-vetdsk48 142 16 the the DT cord-295206-vetdsk48 142 17 elderly elderly JJ cord-295206-vetdsk48 142 18 and and CC cord-295206-vetdsk48 142 19 in in IN cord-295206-vetdsk48 142 20 those those DT cord-295206-vetdsk48 142 21 with with IN cord-295206-vetdsk48 142 22 co co NNS cord-295206-vetdsk48 142 23 - - NNS cord-295206-vetdsk48 142 24 morbidities morbidity NNS cord-295206-vetdsk48 142 25 that that WDT cord-295206-vetdsk48 142 26 place place VBP cord-295206-vetdsk48 142 27 them -PRON- PRP cord-295206-vetdsk48 142 28 at at IN cord-295206-vetdsk48 142 29 high high JJ cord-295206-vetdsk48 142 30 risk risk NN cord-295206-vetdsk48 142 31 of of IN cord-295206-vetdsk48 142 32 pneumonia pneumonia NN cord-295206-vetdsk48 142 33 and and CC cord-295206-vetdsk48 142 34 other other JJ cord-295206-vetdsk48 142 35 complications complication NNS cord-295206-vetdsk48 142 36 . . . cord-295206-vetdsk48 143 1 Chronic chronic JJ cord-295206-vetdsk48 143 2 bronchitis bronchitis NN cord-295206-vetdsk48 143 3 is be VBZ cord-295206-vetdsk48 143 4 a a DT cord-295206-vetdsk48 143 5 manifestation manifestation NN cord-295206-vetdsk48 143 6 of of IN cord-295206-vetdsk48 143 7 chronic chronic JJ cord-295206-vetdsk48 143 8 obstructive obstructive JJ cord-295206-vetdsk48 143 9 pulmonary pulmonary JJ cord-295206-vetdsk48 143 10 disease disease NN cord-295206-vetdsk48 143 11 ( ( -LRB- cord-295206-vetdsk48 143 12 COPD COPD NNP cord-295206-vetdsk48 143 13 ) ) -RRB- cord-295206-vetdsk48 143 14 involving involve VBG cord-295206-vetdsk48 143 15 cough cough NN cord-295206-vetdsk48 143 16 and and CC cord-295206-vetdsk48 143 17 sputum sputum NN cord-295206-vetdsk48 143 18 production production NN cord-295206-vetdsk48 143 19 , , , cord-295206-vetdsk48 143 20 with with IN cord-295206-vetdsk48 143 21 or or CC cord-295206-vetdsk48 143 22 without without IN cord-295206-vetdsk48 143 23 wheezing wheeze VBG cord-295206-vetdsk48 144 1 , , , cord-295206-vetdsk48 144 2 that that DT cord-295206-vetdsk48 144 3 lasts last VBZ cord-295206-vetdsk48 144 4 for for IN cord-295206-vetdsk48 144 5 at at RB cord-295206-vetdsk48 144 6 least least JJS cord-295206-vetdsk48 144 7 3 3 CD cord-295206-vetdsk48 144 8 months month NNS cord-295206-vetdsk48 144 9 for for IN cord-295206-vetdsk48 144 10 2 2 CD cord-295206-vetdsk48 144 11 consecutive consecutive JJ cord-295206-vetdsk48 144 12 years year NNS cord-295206-vetdsk48 144 13 Chitkara Chitkara NNP cord-295206-vetdsk48 144 14 and and CC cord-295206-vetdsk48 144 15 Sarinas Sarinas NNP cord-295206-vetdsk48 144 16 ( ( -LRB- cord-295206-vetdsk48 144 17 2002 2002 CD cord-295206-vetdsk48 144 18 ) ) -RRB- cord-295206-vetdsk48 144 19 . . . cord-295206-vetdsk48 145 1 It -PRON- PRP cord-295206-vetdsk48 145 2 most most RBS cord-295206-vetdsk48 145 3 frequently frequently RB cord-295206-vetdsk48 145 4 appears appear VBZ cord-295206-vetdsk48 145 5 in in IN cord-295206-vetdsk48 145 6 smokers smoker NNS cord-295206-vetdsk48 145 7 over over IN cord-295206-vetdsk48 145 8 the the DT cord-295206-vetdsk48 145 9 age age NN cord-295206-vetdsk48 145 10 of of IN cord-295206-vetdsk48 145 11 40 40 CD cord-295206-vetdsk48 145 12 and and CC cord-295206-vetdsk48 145 13 is be VBZ cord-295206-vetdsk48 145 14 associated associate VBN cord-295206-vetdsk48 145 15 with with IN cord-295206-vetdsk48 145 16 acute acute JJ cord-295206-vetdsk48 145 17 exacerbations exacerbation NNS cord-295206-vetdsk48 145 18 in in IN cord-295206-vetdsk48 145 19 which which WDT cord-295206-vetdsk48 145 20 coughing cough VBG cord-295206-vetdsk48 145 21 , , , cord-295206-vetdsk48 145 22 wheezing wheeze VBG cord-295206-vetdsk48 145 23 , , , cord-295206-vetdsk48 145 24 and and CC cord-295206-vetdsk48 145 25 sputum sputum NN cord-295206-vetdsk48 145 26 production production NN cord-295206-vetdsk48 145 27 are be VBP cord-295206-vetdsk48 145 28 increased increase VBN cord-295206-vetdsk48 145 29 . . . cord-295206-vetdsk48 146 1 Persons person NNS cord-295206-vetdsk48 146 2 with with IN cord-295206-vetdsk48 146 3 chronic chronic JJ cord-295206-vetdsk48 146 4 bronchitis bronchitis NN cord-295206-vetdsk48 146 5 are be VBP cord-295206-vetdsk48 146 6 at at IN cord-295206-vetdsk48 146 7 increased increase VBN cord-295206-vetdsk48 146 8 risk risk NN cord-295206-vetdsk48 146 9 of of IN cord-295206-vetdsk48 146 10 developing develop VBG cord-295206-vetdsk48 146 11 pneumonia pneumonia NN cord-295206-vetdsk48 146 12 and and CC cord-295206-vetdsk48 146 13 other other JJ cord-295206-vetdsk48 146 14 respiratory respiratory JJ cord-295206-vetdsk48 146 15 infections infection NNS cord-295206-vetdsk48 146 16 . . . cord-295206-vetdsk48 147 1 Significant significant JJ cord-295206-vetdsk48 147 2 difficulty difficulty NN cord-295206-vetdsk48 147 3 breathing breathe VBG cord-295206-vetdsk48 147 4 during during IN cord-295206-vetdsk48 147 5 exercise exercise NN cord-295206-vetdsk48 147 6 , , , cord-295206-vetdsk48 147 7 and and CC cord-295206-vetdsk48 147 8 , , , cord-295206-vetdsk48 147 9 as as IN cord-295206-vetdsk48 147 10 the the DT cord-295206-vetdsk48 147 11 disease disease NN cord-295206-vetdsk48 147 12 progresses progress VBZ cord-295206-vetdsk48 147 13 , , , cord-295206-vetdsk48 147 14 also also RB cord-295206-vetdsk48 147 15 at at IN cord-295206-vetdsk48 147 16 rest rest NN cord-295206-vetdsk48 147 17 usually usually RB cord-295206-vetdsk48 147 18 manifest manifest VBP cord-295206-vetdsk48 147 19 during during IN cord-295206-vetdsk48 147 20 the the DT cord-295206-vetdsk48 147 21 mid mid NN cord-295206-vetdsk48 147 22 - - NNS cord-295206-vetdsk48 147 23 sixties sixty NNS cord-295206-vetdsk48 147 24 to to IN cord-295206-vetdsk48 147 25 early early JJ cord-295206-vetdsk48 147 26 seventies seventy NNS cord-295206-vetdsk48 147 27 . . . cord-295206-vetdsk48 148 1 Spirometric spirometric NN cord-295206-vetdsk48 148 2 measurement measurement NN cord-295206-vetdsk48 148 3 of of IN cord-295206-vetdsk48 148 4 the the DT cord-295206-vetdsk48 148 5 forced force VBN cord-295206-vetdsk48 148 6 expiratory expiratory JJ cord-295206-vetdsk48 148 7 volume volume NN cord-295206-vetdsk48 148 8 in in IN cord-295206-vetdsk48 148 9 1 1 CD cord-295206-vetdsk48 148 10 second second NN cord-295206-vetdsk48 148 11 ( ( -LRB- cord-295206-vetdsk48 148 12 FEV FEV NNP cord-295206-vetdsk48 148 13 1 1 CD cord-295206-vetdsk48 148 14 ) ) -RRB- cord-295206-vetdsk48 148 15 and and CC cord-295206-vetdsk48 148 16 the the DT cord-295206-vetdsk48 148 17 forced force VBN cord-295206-vetdsk48 148 18 vital vital JJ cord-295206-vetdsk48 148 19 capacity capacity NN cord-295206-vetdsk48 148 20 ( ( -LRB- cord-295206-vetdsk48 148 21 FVC FVC NNP cord-295206-vetdsk48 148 22 ) ) -RRB- cord-295206-vetdsk48 148 23 may may MD cord-295206-vetdsk48 148 24 be be VB cord-295206-vetdsk48 148 25 used use VBN cord-295206-vetdsk48 148 26 to to TO cord-295206-vetdsk48 148 27 assess assess VB cord-295206-vetdsk48 148 28 pulmonary pulmonary JJ cord-295206-vetdsk48 148 29 function function NN cord-295206-vetdsk48 148 30 and and CC cord-295206-vetdsk48 148 31 to to TO cord-295206-vetdsk48 148 32 stage stage VB cord-295206-vetdsk48 148 33 the the DT cord-295206-vetdsk48 148 34 severity severity NN cord-295206-vetdsk48 148 35 of of IN cord-295206-vetdsk48 148 36 COPD COPD NNP cord-295206-vetdsk48 148 37 Pauwels Pauwels NNP cord-295206-vetdsk48 148 38 et et NNP cord-295206-vetdsk48 148 39 al al NNP cord-295206-vetdsk48 148 40 ( ( -LRB- cord-295206-vetdsk48 148 41 2001 2001 CD cord-295206-vetdsk48 148 42 ) ) -RRB- cord-295206-vetdsk48 148 43 , , , cord-295206-vetdsk48 148 44 Lenfant Lenfant NNP cord-295206-vetdsk48 148 45 and and CC cord-295206-vetdsk48 148 46 Khaltaev Khaltaev NNP cord-295206-vetdsk48 148 47 ( ( -LRB- cord-295206-vetdsk48 148 48 2003 2003 CD cord-295206-vetdsk48 148 49 ) ) -RRB- cord-295206-vetdsk48 148 50 . . . cord-295206-vetdsk48 149 1 A a DT cord-295206-vetdsk48 149 2 complete complete JJ cord-295206-vetdsk48 149 3 blood blood NN cord-295206-vetdsk48 149 4 count count NN cord-295206-vetdsk48 149 5 can can MD cord-295206-vetdsk48 149 6 be be VB cord-295206-vetdsk48 149 7 used use VBN cord-295206-vetdsk48 149 8 to to TO cord-295206-vetdsk48 149 9 rule rule VB cord-295206-vetdsk48 149 10 out out RP cord-295206-vetdsk48 149 11 infection infection NN cord-295206-vetdsk48 149 12 and and CC cord-295206-vetdsk48 149 13 may may MD cord-295206-vetdsk48 149 14 reveal reveal VB cord-295206-vetdsk48 149 15 an an DT cord-295206-vetdsk48 149 16 elevation elevation NN cord-295206-vetdsk48 149 17 in in IN cord-295206-vetdsk48 149 18 red red JJ cord-295206-vetdsk48 149 19 blood blood NN cord-295206-vetdsk48 149 20 cells cell NNS cord-295206-vetdsk48 149 21 resulting result VBG cord-295206-vetdsk48 149 22 from from IN cord-295206-vetdsk48 149 23 chronic chronic JJ cord-295206-vetdsk48 149 24 hypoxemia hypoxemia NN cord-295206-vetdsk48 149 25 ( ( -LRB- cord-295206-vetdsk48 149 26 polycythemia polycythemia NN cord-295206-vetdsk48 149 27 ) ) -RRB- cord-295206-vetdsk48 149 28 . . . cord-295206-vetdsk48 150 1 A a DT cord-295206-vetdsk48 150 2 sputum sputum NN cord-295206-vetdsk48 150 3 culture culture NN cord-295206-vetdsk48 150 4 may may MD cord-295206-vetdsk48 150 5 be be VB cord-295206-vetdsk48 150 6 used use VBN cord-295206-vetdsk48 150 7 to to TO cord-295206-vetdsk48 150 8 check check VB cord-295206-vetdsk48 150 9 for for IN cord-295206-vetdsk48 150 10 acute acute JJ cord-295206-vetdsk48 150 11 infection infection NN cord-295206-vetdsk48 150 12 . . . cord-295206-vetdsk48 151 1 A a DT cord-295206-vetdsk48 151 2 chest chest NN cord-295206-vetdsk48 151 3 X x NN cord-295206-vetdsk48 151 4 - - NN cord-295206-vetdsk48 151 5 ray ray NN cord-295206-vetdsk48 151 6 can can MD cord-295206-vetdsk48 151 7 be be VB cord-295206-vetdsk48 151 8 performed perform VBN cord-295206-vetdsk48 151 9 to to TO cord-295206-vetdsk48 151 10 exclude exclude VB cord-295206-vetdsk48 151 11 other other JJ cord-295206-vetdsk48 151 12 causes cause NNS cord-295206-vetdsk48 151 13 of of IN cord-295206-vetdsk48 151 14 cough cough NN cord-295206-vetdsk48 151 15 such such JJ cord-295206-vetdsk48 151 16 as as IN cord-295206-vetdsk48 151 17 pneumonia pneumonia NN cord-295206-vetdsk48 151 18 and and CC cord-295206-vetdsk48 151 19 lung lung NN cord-295206-vetdsk48 151 20 cancer cancer NN cord-295206-vetdsk48 151 21 . . . cord-295206-vetdsk48 152 1 In in IN cord-295206-vetdsk48 152 2 severe severe JJ cord-295206-vetdsk48 152 3 cases case NNS cord-295206-vetdsk48 152 4 of of IN cord-295206-vetdsk48 152 5 chronic chronic JJ cord-295206-vetdsk48 152 6 bronchitis bronchitis NN cord-295206-vetdsk48 152 7 , , , cord-295206-vetdsk48 152 8 radiography radiography NN cord-295206-vetdsk48 152 9 may may MD cord-295206-vetdsk48 152 10 reveal reveal VB cord-295206-vetdsk48 152 11 right right JJ cord-295206-vetdsk48 152 12 ventricular ventricular JJ cord-295206-vetdsk48 152 13 hypertrophy hypertrophy NN cord-295206-vetdsk48 152 14 as as RB cord-295206-vetdsk48 152 15 well well RB cord-295206-vetdsk48 152 16 as as IN cord-295206-vetdsk48 152 17 enlargement enlargement NN cord-295206-vetdsk48 152 18 and and CC cord-295206-vetdsk48 152 19 rapid rapid JJ cord-295206-vetdsk48 152 20 tapering tapering NN cord-295206-vetdsk48 152 21 of of IN cord-295206-vetdsk48 152 22 the the DT cord-295206-vetdsk48 152 23 pulmonary pulmonary JJ cord-295206-vetdsk48 152 24 arteries artery NNS cord-295206-vetdsk48 152 25 . . . cord-295206-vetdsk48 153 1 If if IN cord-295206-vetdsk48 153 2 emphysema emphysema NN cord-295206-vetdsk48 153 3 is be VBZ cord-295206-vetdsk48 153 4 present present JJ cord-295206-vetdsk48 153 5 as as RB cord-295206-vetdsk48 153 6 well well RB cord-295206-vetdsk48 153 7 , , , cord-295206-vetdsk48 153 8 each each DT cord-295206-vetdsk48 153 9 region region NN cord-295206-vetdsk48 153 10 of of IN cord-295206-vetdsk48 153 11 severe severe JJ cord-295206-vetdsk48 153 12 disease disease NN cord-295206-vetdsk48 153 13 will will MD cord-295206-vetdsk48 153 14 be be VB cord-295206-vetdsk48 153 15 visible visible JJ cord-295206-vetdsk48 153 16 as as IN cord-295206-vetdsk48 153 17 a a DT cord-295206-vetdsk48 153 18 radiolucent radiolucent NN cord-295206-vetdsk48 153 19 area area NN cord-295206-vetdsk48 153 20 surrounded surround VBN cord-295206-vetdsk48 153 21 by by IN cord-295206-vetdsk48 153 22 a a DT cord-295206-vetdsk48 153 23 hairline hairline NN cord-295206-vetdsk48 153 24 shadow shadow NN cord-295206-vetdsk48 153 25 . . . cord-295206-vetdsk48 154 1 Acute acute JJ cord-295206-vetdsk48 154 2 exacerbations exacerbation NNS cord-295206-vetdsk48 154 3 of of IN cord-295206-vetdsk48 154 4 chronic chronic JJ cord-295206-vetdsk48 154 5 bronchitis bronchitis NN cord-295206-vetdsk48 154 6 are be VBP cord-295206-vetdsk48 154 7 associated associate VBN cord-295206-vetdsk48 154 8 with with IN cord-295206-vetdsk48 154 9 worsened worsened JJ cord-295206-vetdsk48 154 10 dyspnea dyspnea NN cord-295206-vetdsk48 154 11 and and CC cord-295206-vetdsk48 154 12 increased increase VBN cord-295206-vetdsk48 154 13 sputum sputum NN cord-295206-vetdsk48 154 14 production production NN cord-295206-vetdsk48 154 15 and and CC cord-295206-vetdsk48 154 16 purulence purulence NN cord-295206-vetdsk48 154 17 . . . cord-295206-vetdsk48 155 1 Acute acute JJ cord-295206-vetdsk48 155 2 exacerbations exacerbation NNS cord-295206-vetdsk48 155 3 can can MD cord-295206-vetdsk48 155 4 be be VB cord-295206-vetdsk48 155 5 classified classify VBN cord-295206-vetdsk48 155 6 as as IN cord-295206-vetdsk48 155 7 severe severe JJ cord-295206-vetdsk48 155 8 ( ( -LRB- cord-295206-vetdsk48 155 9 type type NN cord-295206-vetdsk48 155 10 1 1 CD cord-295206-vetdsk48 155 11 ) ) -RRB- cord-295206-vetdsk48 155 12 if if IN cord-295206-vetdsk48 155 13 all all DT cord-295206-vetdsk48 155 14 three three CD cord-295206-vetdsk48 155 15 symptoms symptom NNS cord-295206-vetdsk48 155 16 are be VBP cord-295206-vetdsk48 155 17 present present JJ cord-295206-vetdsk48 155 18 and and CC cord-295206-vetdsk48 155 19 moderate moderate JJ cord-295206-vetdsk48 155 20 ( ( -LRB- cord-295206-vetdsk48 155 21 type type NN cord-295206-vetdsk48 155 22 2 2 CD cord-295206-vetdsk48 155 23 ) ) -RRB- cord-295206-vetdsk48 155 24 if if IN cord-295206-vetdsk48 155 25 two two CD cord-295206-vetdsk48 155 26 of of IN cord-295206-vetdsk48 155 27 the the DT cord-295206-vetdsk48 155 28 three three CD cord-295206-vetdsk48 155 29 are be VBP cord-295206-vetdsk48 155 30 present present JJ cord-295206-vetdsk48 155 31 McCrory McCrory NNP cord-295206-vetdsk48 155 32 et et NNP cord-295206-vetdsk48 155 33 al al NNP cord-295206-vetdsk48 155 34 ( ( -LRB- cord-295206-vetdsk48 155 35 2001 2001 CD cord-295206-vetdsk48 155 36 ) ) -RRB- cord-295206-vetdsk48 155 37 . . . cord-295206-vetdsk48 156 1 A a DT cord-295206-vetdsk48 156 2 mild mild JJ cord-295206-vetdsk48 156 3 exacerbation exacerbation NN cord-295206-vetdsk48 156 4 is be VBZ cord-295206-vetdsk48 156 5 diagnosed diagnose VBN cord-295206-vetdsk48 156 6 if if IN cord-295206-vetdsk48 156 7 one one CD cord-295206-vetdsk48 156 8 of of IN cord-295206-vetdsk48 156 9 the the DT cord-295206-vetdsk48 156 10 above above JJ cord-295206-vetdsk48 156 11 symptoms symptom NNS cord-295206-vetdsk48 156 12 occurs occur VBZ cord-295206-vetdsk48 156 13 along along RB cord-295206-vetdsk48 156 14 with with IN cord-295206-vetdsk48 156 15 at at RB cord-295206-vetdsk48 156 16 least least RBS cord-295206-vetdsk48 156 17 one one CD cord-295206-vetdsk48 156 18 indicator indicator NN cord-295206-vetdsk48 156 19 of of IN cord-295206-vetdsk48 156 20 recent recent JJ cord-295206-vetdsk48 156 21 respiratory respiratory JJ cord-295206-vetdsk48 156 22 infection infection NN cord-295206-vetdsk48 156 23 ( ( -LRB- cord-295206-vetdsk48 156 24 e.g. e.g. RB cord-295206-vetdsk48 156 25 , , , cord-295206-vetdsk48 156 26 fever fever NN cord-295206-vetdsk48 156 27 , , , cord-295206-vetdsk48 156 28 cough cough NN cord-295206-vetdsk48 156 29 , , , cord-295206-vetdsk48 156 30 and and CC cord-295206-vetdsk48 156 31 wheezing wheeze VBG cord-295206-vetdsk48 156 32 ) ) -RRB- cord-295206-vetdsk48 156 33 . . . cord-295206-vetdsk48 157 1 Because because IN cord-295206-vetdsk48 157 2 of of IN cord-295206-vetdsk48 157 3 its -PRON- PRP$ cord-295206-vetdsk48 157 4 predominantly predominantly RB cord-295206-vetdsk48 157 5 viral viral JJ cord-295206-vetdsk48 157 6 nature nature NN cord-295206-vetdsk48 157 7 , , , cord-295206-vetdsk48 157 8 acute acute JJ cord-295206-vetdsk48 157 9 bronchitis bronchitis NN cord-295206-vetdsk48 157 10 is be VBZ cord-295206-vetdsk48 157 11 best well RBS cord-295206-vetdsk48 157 12 treated treat VBN cord-295206-vetdsk48 157 13 symptomatically symptomatically RB cord-295206-vetdsk48 157 14 , , , cord-295206-vetdsk48 157 15 unless unless IN cord-295206-vetdsk48 157 16 an an DT cord-295206-vetdsk48 157 17 influenza influenza NN cord-295206-vetdsk48 157 18 etiology etiology NN cord-295206-vetdsk48 157 19 is be VBZ cord-295206-vetdsk48 157 20 established establish VBN cord-295206-vetdsk48 157 21 and and CC cord-295206-vetdsk48 157 22 antiviral antiviral JJ cord-295206-vetdsk48 157 23 treatment treatment NN cord-295206-vetdsk48 157 24 is be VBZ cord-295206-vetdsk48 157 25 initiated initiate VBN cord-295206-vetdsk48 157 26 early early JJ cord-295206-vetdsk48 157 27 enough enough RB cord-295206-vetdsk48 157 28 to to TO cord-295206-vetdsk48 157 29 ensure ensure VB cord-295206-vetdsk48 157 30 effectiveness effectiveness NN cord-295206-vetdsk48 157 31 . . . cord-295206-vetdsk48 158 1 Antibiotics antibiotic NNS cord-295206-vetdsk48 158 2 are be VBP cord-295206-vetdsk48 158 3 useful useful JJ cord-295206-vetdsk48 158 4 in in IN cord-295206-vetdsk48 158 5 cases case NNS cord-295206-vetdsk48 158 6 where where WRB cord-295206-vetdsk48 158 7 bacterial bacterial JJ cord-295206-vetdsk48 158 8 infection infection NN cord-295206-vetdsk48 158 9 is be VBZ cord-295206-vetdsk48 158 10 confirmed confirm VBN cord-295206-vetdsk48 158 11 . . . cord-295206-vetdsk48 159 1 The the DT cord-295206-vetdsk48 159 2 medications medication NNS cord-295206-vetdsk48 159 3 available available JJ cord-295206-vetdsk48 159 4 for for IN cord-295206-vetdsk48 159 5 the the DT cord-295206-vetdsk48 159 6 treatment treatment NN cord-295206-vetdsk48 159 7 of of IN cord-295206-vetdsk48 159 8 chronic chronic JJ cord-295206-vetdsk48 159 9 bronchitis bronchitis NN cord-295206-vetdsk48 159 10 / / SYM cord-295206-vetdsk48 159 11 chronic chronic JJ cord-295206-vetdsk48 159 12 obstructive obstructive JJ cord-295206-vetdsk48 159 13 pulmonary pulmonary JJ cord-295206-vetdsk48 159 14 disease disease NN cord-295206-vetdsk48 159 15 ( ( -LRB- cord-295206-vetdsk48 159 16 COPD COPD NNP cord-295206-vetdsk48 159 17 ) ) -RRB- cord-295206-vetdsk48 159 18 do do VBP cord-295206-vetdsk48 159 19 not not RB cord-295206-vetdsk48 159 20 decrease decrease VB cord-295206-vetdsk48 159 21 the the DT cord-295206-vetdsk48 159 22 progressive progressive JJ cord-295206-vetdsk48 159 23 decline decline NN cord-295206-vetdsk48 159 24 in in IN cord-295206-vetdsk48 159 25 respiratory respiratory JJ cord-295206-vetdsk48 159 26 function function NN cord-295206-vetdsk48 159 27 that that WDT cord-295206-vetdsk48 159 28 is be VBZ cord-295206-vetdsk48 159 29 characteristic characteristic JJ cord-295206-vetdsk48 159 30 of of IN cord-295206-vetdsk48 159 31 this this DT cord-295206-vetdsk48 159 32 condition condition NN cord-295206-vetdsk48 159 33 . . . cord-295206-vetdsk48 160 1 Rather rather RB cord-295206-vetdsk48 160 2 , , , cord-295206-vetdsk48 160 3 they -PRON- PRP cord-295206-vetdsk48 160 4 only only RB cord-295206-vetdsk48 160 5 lessen lessen VBP cord-295206-vetdsk48 160 6 its -PRON- PRP$ cord-295206-vetdsk48 160 7 symptoms symptom NNS cord-295206-vetdsk48 160 8 and and CC cord-295206-vetdsk48 160 9 their -PRON- PRP$ cord-295206-vetdsk48 160 10 complications complication NNS cord-295206-vetdsk48 160 11 . . . cord-295206-vetdsk48 161 1 The the DT cord-295206-vetdsk48 161 2 only only JJ cord-295206-vetdsk48 161 3 intervention intervention NN cord-295206-vetdsk48 161 4 that that WDT cord-295206-vetdsk48 161 5 slows slow VBZ cord-295206-vetdsk48 161 6 the the DT cord-295206-vetdsk48 161 7 progression progression NN cord-295206-vetdsk48 161 8 of of IN cord-295206-vetdsk48 161 9 COPD COPD NNP cord-295206-vetdsk48 161 10 is be VBZ cord-295206-vetdsk48 161 11 decreased decrease VBN cord-295206-vetdsk48 161 12 exposure(s exposure(s NNP cord-295206-vetdsk48 161 13 ) ) -RRB- cord-295206-vetdsk48 161 14 to to IN cord-295206-vetdsk48 161 15 substances substance NNS cord-295206-vetdsk48 161 16 that that WDT cord-295206-vetdsk48 161 17 worsen worsen VBP cord-295206-vetdsk48 161 18 this this DT cord-295206-vetdsk48 161 19 condition condition NN cord-295206-vetdsk48 161 20 such such JJ cord-295206-vetdsk48 161 21 as as IN cord-295206-vetdsk48 161 22 tobacco tobacco NN cord-295206-vetdsk48 161 23 smoke smoke NN cord-295206-vetdsk48 161 24 , , , cord-295206-vetdsk48 161 25 occupational occupational JJ cord-295206-vetdsk48 161 26 dusts dust NNS cord-295206-vetdsk48 161 27 and and CC cord-295206-vetdsk48 161 28 chemicals chemical NNS cord-295206-vetdsk48 161 29 , , , cord-295206-vetdsk48 161 30 and and CC cord-295206-vetdsk48 161 31 air air NN cord-295206-vetdsk48 161 32 pollutants pollutant NNS cord-295206-vetdsk48 161 33 . . . cord-295206-vetdsk48 162 1 Smoking smoking NN cord-295206-vetdsk48 162 2 cessation cessation NN cord-295206-vetdsk48 162 3 is be VBZ cord-295206-vetdsk48 162 4 the the DT cord-295206-vetdsk48 162 5 most most RBS cord-295206-vetdsk48 162 6 significant significant JJ cord-295206-vetdsk48 162 7 intervention intervention NN cord-295206-vetdsk48 162 8 that that WDT cord-295206-vetdsk48 162 9 has have VBZ cord-295206-vetdsk48 162 10 the the DT cord-295206-vetdsk48 162 11 potential potential NN cord-295206-vetdsk48 162 12 to to TO cord-295206-vetdsk48 162 13 slow slow VB cord-295206-vetdsk48 162 14 the the DT cord-295206-vetdsk48 162 15 progression progression NN cord-295206-vetdsk48 162 16 of of IN cord-295206-vetdsk48 162 17 chronic chronic JJ cord-295206-vetdsk48 162 18 obstructive obstructive JJ cord-295206-vetdsk48 162 19 pulmonary pulmonary JJ cord-295206-vetdsk48 162 20 disease disease NN cord-295206-vetdsk48 162 21 Chitkara Chitkara NNP cord-295206-vetdsk48 162 22 and and CC cord-295206-vetdsk48 162 23 Sarinas Sarinas NNP cord-295206-vetdsk48 162 24 ( ( -LRB- cord-295206-vetdsk48 162 25 2002 2002 CD cord-295206-vetdsk48 162 26 ) ) -RRB- cord-295206-vetdsk48 162 27 . . . cord-295206-vetdsk48 163 1 Pharmacological pharmacological JJ cord-295206-vetdsk48 163 2 therapy therapy NN cord-295206-vetdsk48 163 3 for for IN cord-295206-vetdsk48 163 4 tobacco tobacco NN cord-295206-vetdsk48 163 5 dependence dependence NN cord-295206-vetdsk48 163 6 is be VBZ cord-295206-vetdsk48 163 7 added add VBN cord-295206-vetdsk48 163 8 to to IN cord-295206-vetdsk48 163 9 counseling counsel VBG cord-295206-vetdsk48 163 10 to to TO cord-295206-vetdsk48 163 11 increase increase VB cord-295206-vetdsk48 163 12 the the DT cord-295206-vetdsk48 163 13 likelihood likelihood NN cord-295206-vetdsk48 163 14 of of IN cord-295206-vetdsk48 163 15 success success NN cord-295206-vetdsk48 163 16 . . . cord-295206-vetdsk48 164 1 Nicotine nicotine NN cord-295206-vetdsk48 164 2 replacement replacement NN cord-295206-vetdsk48 164 3 therapy therapy NN cord-295206-vetdsk48 164 4 is be VBZ cord-295206-vetdsk48 164 5 most most RBS cord-295206-vetdsk48 164 6 commonly commonly RB cord-295206-vetdsk48 164 7 given give VBN cord-295206-vetdsk48 164 8 as as IN cord-295206-vetdsk48 164 9 a a DT cord-295206-vetdsk48 164 10 transdermal transdermal JJ cord-295206-vetdsk48 164 11 patch patch NN cord-295206-vetdsk48 164 12 , , , cord-295206-vetdsk48 164 13 with with IN cord-295206-vetdsk48 164 14 nicotine nicotine NN cord-295206-vetdsk48 164 15 gum gum NN cord-295206-vetdsk48 164 16 , , , cord-295206-vetdsk48 164 17 nasal nasal NN cord-295206-vetdsk48 164 18 spray spray NN cord-295206-vetdsk48 164 19 , , , cord-295206-vetdsk48 164 20 inhaler inhaler NN cord-295206-vetdsk48 164 21 , , , cord-295206-vetdsk48 164 22 or or CC cord-295206-vetdsk48 164 23 lozenge lozenge NN cord-295206-vetdsk48 164 24 used use VBD cord-295206-vetdsk48 164 25 to to TO cord-295206-vetdsk48 164 26 counteract counteract VB cord-295206-vetdsk48 164 27 breakthrough breakthrough NN cord-295206-vetdsk48 164 28 cravings craving NNS cord-295206-vetdsk48 164 29 . . . cord-295206-vetdsk48 165 1 Smoking smoking NN cord-295206-vetdsk48 165 2 cessation cessation NN cord-295206-vetdsk48 165 3 is be VBZ cord-295206-vetdsk48 165 4 more more RBR cord-295206-vetdsk48 165 5 likely likely JJ cord-295206-vetdsk48 165 6 to to TO cord-295206-vetdsk48 165 7 succeed succeed VB cord-295206-vetdsk48 165 8 when when WRB cord-295206-vetdsk48 165 9 nicotine nicotine NN cord-295206-vetdsk48 165 10 replacement replacement NN cord-295206-vetdsk48 165 11 therapy therapy NN cord-295206-vetdsk48 165 12 is be VBZ cord-295206-vetdsk48 165 13 used use VBN cord-295206-vetdsk48 165 14 in in IN cord-295206-vetdsk48 165 15 combination combination NN cord-295206-vetdsk48 165 16 with with IN cord-295206-vetdsk48 165 17 the the DT cord-295206-vetdsk48 165 18 antidepressant antidepressant NN cord-295206-vetdsk48 165 19 bupropion bupropion NN cord-295206-vetdsk48 165 20 . . . cord-295206-vetdsk48 166 1 With with IN cord-295206-vetdsk48 166 2 this this DT cord-295206-vetdsk48 166 3 combination combination NN cord-295206-vetdsk48 166 4 , , , cord-295206-vetdsk48 166 5 nicotine nicotine NN cord-295206-vetdsk48 166 6 is be VBZ cord-295206-vetdsk48 166 7 gradually gradually RB cord-295206-vetdsk48 166 8 withdrawn withdraw VBN cord-295206-vetdsk48 166 9 while while IN cord-295206-vetdsk48 166 10 bupropion bupropion NNP cord-295206-vetdsk48 166 11 is be VBZ cord-295206-vetdsk48 166 12 maintained maintain VBN cord-295206-vetdsk48 166 13 for for IN cord-295206-vetdsk48 166 14 12 12 CD cord-295206-vetdsk48 166 15 months month NNS cord-295206-vetdsk48 166 16 or or CC cord-295206-vetdsk48 166 17 longer long JJR cord-295206-vetdsk48 166 18 . . . cord-295206-vetdsk48 167 1 Those those DT cord-295206-vetdsk48 167 2 with with IN cord-295206-vetdsk48 167 3 acute acute JJ cord-295206-vetdsk48 167 4 bronchitis bronchitis NN cord-295206-vetdsk48 167 5 frequently frequently RB cord-295206-vetdsk48 167 6 exhibit exhibit VBP cord-295206-vetdsk48 167 7 wheezing wheezing NN cord-295206-vetdsk48 167 8 and and CC cord-295206-vetdsk48 167 9 other other JJ cord-295206-vetdsk48 167 10 signs sign NNS cord-295206-vetdsk48 167 11 of of IN cord-295206-vetdsk48 167 12 reversible reversible JJ cord-295206-vetdsk48 167 13 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 167 14 . . . cord-295206-vetdsk48 168 1 Although although IN cord-295206-vetdsk48 168 2 chronic chronic JJ cord-295206-vetdsk48 168 3 obstructive obstructive JJ cord-295206-vetdsk48 168 4 pulmonary pulmonary JJ cord-295206-vetdsk48 168 5 disease disease NN cord-295206-vetdsk48 168 6 is be VBZ cord-295206-vetdsk48 168 7 characterized characterize VBN cord-295206-vetdsk48 168 8 by by IN cord-295206-vetdsk48 168 9 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 168 10 that that WDT cord-295206-vetdsk48 168 11 is be VBZ cord-295206-vetdsk48 168 12 incompletely incompletely RB cord-295206-vetdsk48 168 13 reversible reversible JJ cord-295206-vetdsk48 168 14 following follow VBG cord-295206-vetdsk48 168 15 administration administration NN cord-295206-vetdsk48 168 16 of of IN cord-295206-vetdsk48 168 17 a a DT cord-295206-vetdsk48 168 18 bronchodilator bronchodilator NN cord-295206-vetdsk48 168 19 , , , cord-295206-vetdsk48 168 20 long long JJ cord-295206-vetdsk48 168 21 - - HYPH cord-295206-vetdsk48 168 22 term term NN cord-295206-vetdsk48 168 23 therapy therapy NN cord-295206-vetdsk48 168 24 with with IN cord-295206-vetdsk48 168 25 bronchodilators bronchodilator NNS cord-295206-vetdsk48 168 26 decreases decrease VBZ cord-295206-vetdsk48 168 27 the the DT cord-295206-vetdsk48 168 28 symptoms symptom NNS cord-295206-vetdsk48 168 29 of of IN cord-295206-vetdsk48 168 30 airflow airflow NN cord-295206-vetdsk48 168 31 limitation limitation NN cord-295206-vetdsk48 168 32 in in IN cord-295206-vetdsk48 168 33 individuals individual NNS cord-295206-vetdsk48 168 34 with with IN cord-295206-vetdsk48 168 35 chronic chronic JJ cord-295206-vetdsk48 168 36 bronchitis bronchitis NN cord-295206-vetdsk48 168 37 . . . cord-295206-vetdsk48 169 1 Thus thus RB cord-295206-vetdsk48 169 2 , , , cord-295206-vetdsk48 169 3 bronchodilator bronchodilator NN cord-295206-vetdsk48 169 4 therapy therapy NN cord-295206-vetdsk48 169 5 is be VBZ cord-295206-vetdsk48 169 6 central central JJ cord-295206-vetdsk48 169 7 to to IN cord-295206-vetdsk48 169 8 the the DT cord-295206-vetdsk48 169 9 management management NN cord-295206-vetdsk48 169 10 of of IN cord-295206-vetdsk48 169 11 chronic chronic JJ cord-295206-vetdsk48 169 12 bronchitis bronchitis NN cord-295206-vetdsk48 169 13 and and CC cord-295206-vetdsk48 169 14 its -PRON- PRP$ cord-295206-vetdsk48 169 15 acute acute JJ cord-295206-vetdsk48 169 16 exacerbations exacerbation NNS cord-295206-vetdsk48 169 17 Chitkara Chitkara NNP cord-295206-vetdsk48 169 18 and and CC cord-295206-vetdsk48 169 19 Sarinas Sarinas NNP cord-295206-vetdsk48 169 20 ( ( -LRB- cord-295206-vetdsk48 169 21 2002 2002 CD cord-295206-vetdsk48 169 22 ) ) -RRB- cord-295206-vetdsk48 169 23 . . . cord-295206-vetdsk48 170 1 Inhalation inhalation NN cord-295206-vetdsk48 170 2 is be VBZ cord-295206-vetdsk48 170 3 the the DT cord-295206-vetdsk48 170 4 preferred preferred JJ cord-295206-vetdsk48 170 5 route route NN cord-295206-vetdsk48 170 6 of of IN cord-295206-vetdsk48 170 7 administration administration NN cord-295206-vetdsk48 170 8 because because IN cord-295206-vetdsk48 170 9 it -PRON- PRP cord-295206-vetdsk48 170 10 maximizes maximize VBZ cord-295206-vetdsk48 170 11 the the DT cord-295206-vetdsk48 170 12 delivery delivery NN cord-295206-vetdsk48 170 13 of of IN cord-295206-vetdsk48 170 14 the the DT cord-295206-vetdsk48 170 15 agent agent NN cord-295206-vetdsk48 170 16 to to IN cord-295206-vetdsk48 170 17 the the DT cord-295206-vetdsk48 170 18 lungs lung NNS cord-295206-vetdsk48 170 19 and and CC cord-295206-vetdsk48 170 20 minimizes minimize VBZ cord-295206-vetdsk48 170 21 systemic systemic JJ cord-295206-vetdsk48 170 22 side side NN cord-295206-vetdsk48 170 23 effects effect NNS cord-295206-vetdsk48 170 24 . . . cord-295206-vetdsk48 171 1 Short short JJ cord-295206-vetdsk48 171 2 - - HYPH cord-295206-vetdsk48 171 3 acting act VBG cord-295206-vetdsk48 171 4 beta-2 beta-2 NN cord-295206-vetdsk48 171 5 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 171 6 agonists agonist NNS cord-295206-vetdsk48 171 7 such such JJ cord-295206-vetdsk48 171 8 as as IN cord-295206-vetdsk48 171 9 albuterol albuterol NNP cord-295206-vetdsk48 171 10 produce produce VBP cord-295206-vetdsk48 171 11 rapid rapid JJ cord-295206-vetdsk48 171 12 bronchodilation bronchodilation NN cord-295206-vetdsk48 171 13 by by IN cord-295206-vetdsk48 171 14 action action NN cord-295206-vetdsk48 171 15 on on IN cord-295206-vetdsk48 171 16 the the DT cord-295206-vetdsk48 171 17 beta-2 beta-2 NN cord-295206-vetdsk48 171 18 adrenoceptors adrenoceptor NNS cord-295206-vetdsk48 171 19 on on IN cord-295206-vetdsk48 171 20 the the DT cord-295206-vetdsk48 171 21 airway airway NN cord-295206-vetdsk48 171 22 smooth smooth JJ cord-295206-vetdsk48 171 23 muscle muscle NN cord-295206-vetdsk48 171 24 . . . cord-295206-vetdsk48 172 1 Anticholinergics anticholinergic NNS cord-295206-vetdsk48 172 2 are be VBP cord-295206-vetdsk48 172 3 the the DT cord-295206-vetdsk48 172 4 preferred preferred JJ cord-295206-vetdsk48 172 5 drugs drug NNS cord-295206-vetdsk48 172 6 for for IN cord-295206-vetdsk48 172 7 the the DT cord-295206-vetdsk48 172 8 treatment treatment NN cord-295206-vetdsk48 172 9 of of IN cord-295206-vetdsk48 172 10 acute acute JJ cord-295206-vetdsk48 172 11 bronchitis bronchitis NN cord-295206-vetdsk48 172 12 Smuncy Smuncy NNP cord-295206-vetdsk48 172 13 et et NNP cord-295206-vetdsk48 172 14 al al NNP cord-295206-vetdsk48 172 15 ( ( -LRB- cord-295206-vetdsk48 172 16 2003 2003 CD cord-295206-vetdsk48 172 17 ) ) -RRB- cord-295206-vetdsk48 172 18 . . . cord-295206-vetdsk48 173 1 In in IN cord-295206-vetdsk48 173 2 the the DT cord-295206-vetdsk48 173 3 treatment treatment NN cord-295206-vetdsk48 173 4 of of IN cord-295206-vetdsk48 173 5 chronic chronic JJ cord-295206-vetdsk48 173 6 bronchitis bronchitis NN cord-295206-vetdsk48 173 7 , , , cord-295206-vetdsk48 173 8 beta-2 beta-2 NN cord-295206-vetdsk48 173 9 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 173 10 agonists agonist NNS cord-295206-vetdsk48 173 11 may may MD cord-295206-vetdsk48 173 12 be be VB cord-295206-vetdsk48 173 13 used use VBN cord-295206-vetdsk48 173 14 on on IN cord-295206-vetdsk48 173 15 a a DT cord-295206-vetdsk48 173 16 scheduled schedule VBN cord-295206-vetdsk48 173 17 basis basis NN cord-295206-vetdsk48 173 18 or or CC cord-295206-vetdsk48 173 19 as as RB cord-295206-vetdsk48 173 20 - - HYPH cord-295206-vetdsk48 173 21 needed need VBN cord-295206-vetdsk48 173 22 to to TO cord-295206-vetdsk48 173 23 treat treat VB cord-295206-vetdsk48 173 24 acute acute JJ cord-295206-vetdsk48 173 25 bronchospasm bronchospasm NN cord-295206-vetdsk48 173 26 . . . cord-295206-vetdsk48 174 1 Beta-2 beta-2 NN cord-295206-vetdsk48 175 1 adrenoceptor adrenoceptor NNP cord-295206-vetdsk48 175 2 agonists agonist NNS cord-295206-vetdsk48 175 3 are be VBP cord-295206-vetdsk48 175 4 also also RB cord-295206-vetdsk48 175 5 used use VBN cord-295206-vetdsk48 175 6 in in IN cord-295206-vetdsk48 175 7 the the DT cord-295206-vetdsk48 175 8 treatment treatment NN cord-295206-vetdsk48 175 9 of of IN cord-295206-vetdsk48 175 10 acute acute JJ cord-295206-vetdsk48 175 11 exacerbations exacerbation NNS cord-295206-vetdsk48 175 12 of of IN cord-295206-vetdsk48 175 13 chronic chronic JJ cord-295206-vetdsk48 175 14 bronchitis bronchitis NN cord-295206-vetdsk48 175 15 McCrory McCrory NNP cord-295206-vetdsk48 175 16 et et NNP cord-295206-vetdsk48 175 17 al al NNP cord-295206-vetdsk48 175 18 ( ( -LRB- cord-295206-vetdsk48 175 19 2001 2001 CD cord-295206-vetdsk48 175 20 ) ) -RRB- cord-295206-vetdsk48 175 21 . . . cord-295206-vetdsk48 176 1 The the DT cord-295206-vetdsk48 176 2 efficacy efficacy NN cord-295206-vetdsk48 176 3 of of IN cord-295206-vetdsk48 176 4 long long RB cord-295206-vetdsk48 176 5 - - HYPH cord-295206-vetdsk48 176 6 acting act VBG cord-295206-vetdsk48 176 7 beta-2 beta-2 NN cord-295206-vetdsk48 176 8 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 176 9 agonists agonist NNS cord-295206-vetdsk48 176 10 such such JJ cord-295206-vetdsk48 176 11 as as IN cord-295206-vetdsk48 176 12 salmeterol salmeterol NN cord-295206-vetdsk48 176 13 is be VBZ cord-295206-vetdsk48 176 14 under under IN cord-295206-vetdsk48 176 15 study study NN cord-295206-vetdsk48 176 16 . . . cord-295206-vetdsk48 177 1 The the DT cord-295206-vetdsk48 177 2 bronchodilatory bronchodilatory JJ cord-295206-vetdsk48 177 3 effect effect NN cord-295206-vetdsk48 177 4 of of IN cord-295206-vetdsk48 177 5 anticholinergics anticholinergic NNS cord-295206-vetdsk48 177 6 is be VBZ cord-295206-vetdsk48 177 7 additive additive NN cord-295206-vetdsk48 177 8 with with IN cord-295206-vetdsk48 177 9 that that DT cord-295206-vetdsk48 177 10 of of IN cord-295206-vetdsk48 177 11 beta-2 beta-2 NN cord-295206-vetdsk48 177 12 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 177 13 agonists agonist NNS cord-295206-vetdsk48 177 14 . . . cord-295206-vetdsk48 178 1 Combination combination NN cord-295206-vetdsk48 178 2 products product NNS cord-295206-vetdsk48 178 3 that that WDT cord-295206-vetdsk48 178 4 deliver deliver VBP cord-295206-vetdsk48 178 5 a a DT cord-295206-vetdsk48 178 6 metered metered JJ cord-295206-vetdsk48 178 7 dose dose NN cord-295206-vetdsk48 178 8 of of IN cord-295206-vetdsk48 178 9 a a DT cord-295206-vetdsk48 178 10 beta-2 beta-2 NN cord-295206-vetdsk48 178 11 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 178 12 agonist agonist NN cord-295206-vetdsk48 178 13 and and CC cord-295206-vetdsk48 178 14 ipratropium ipratropium NNP cord-295206-vetdsk48 178 15 can can MD cord-295206-vetdsk48 178 16 simplify simplify VB cord-295206-vetdsk48 178 17 drug drug NN cord-295206-vetdsk48 178 18 administration administration NN cord-295206-vetdsk48 178 19 . . . cord-295206-vetdsk48 179 1 Those those DT cord-295206-vetdsk48 179 2 with with IN cord-295206-vetdsk48 179 3 acute acute JJ cord-295206-vetdsk48 179 4 bronchitis bronchitis NN cord-295206-vetdsk48 179 5 frequently frequently RB cord-295206-vetdsk48 179 6 exhibit exhibit VBP cord-295206-vetdsk48 179 7 wheezing wheezing NN cord-295206-vetdsk48 179 8 and and CC cord-295206-vetdsk48 179 9 other other JJ cord-295206-vetdsk48 179 10 signs sign NNS cord-295206-vetdsk48 179 11 of of IN cord-295206-vetdsk48 179 12 reversible reversible JJ cord-295206-vetdsk48 179 13 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 179 14 . . . cord-295206-vetdsk48 180 1 Although although IN cord-295206-vetdsk48 180 2 chronic chronic JJ cord-295206-vetdsk48 180 3 obstructive obstructive JJ cord-295206-vetdsk48 180 4 pulmonary pulmonary JJ cord-295206-vetdsk48 180 5 disease disease NN cord-295206-vetdsk48 180 6 is be VBZ cord-295206-vetdsk48 180 7 characterized characterize VBN cord-295206-vetdsk48 180 8 by by IN cord-295206-vetdsk48 180 9 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 180 10 that that WDT cord-295206-vetdsk48 180 11 is be VBZ cord-295206-vetdsk48 180 12 incompletely incompletely RB cord-295206-vetdsk48 180 13 reversible reversible JJ cord-295206-vetdsk48 180 14 following follow VBG cord-295206-vetdsk48 180 15 administration administration NN cord-295206-vetdsk48 180 16 of of IN cord-295206-vetdsk48 180 17 a a DT cord-295206-vetdsk48 180 18 bronchodilator bronchodilator NN cord-295206-vetdsk48 180 19 , , , cord-295206-vetdsk48 180 20 long long JJ cord-295206-vetdsk48 180 21 - - HYPH cord-295206-vetdsk48 180 22 term term NN cord-295206-vetdsk48 180 23 therapy therapy NN cord-295206-vetdsk48 180 24 with with IN cord-295206-vetdsk48 180 25 bronchodilators bronchodilator NNS cord-295206-vetdsk48 180 26 decreases decrease VBZ cord-295206-vetdsk48 180 27 the the DT cord-295206-vetdsk48 180 28 symptoms symptom NNS cord-295206-vetdsk48 180 29 of of IN cord-295206-vetdsk48 180 30 airflow airflow NN cord-295206-vetdsk48 180 31 limitation limitation NN cord-295206-vetdsk48 180 32 in in IN cord-295206-vetdsk48 180 33 individuals individual NNS cord-295206-vetdsk48 180 34 with with IN cord-295206-vetdsk48 180 35 chronic chronic JJ cord-295206-vetdsk48 180 36 bronchitis bronchitis NN cord-295206-vetdsk48 180 37 . . . cord-295206-vetdsk48 181 1 Thus thus RB cord-295206-vetdsk48 181 2 , , , cord-295206-vetdsk48 181 3 bronchodilator bronchodilator NN cord-295206-vetdsk48 181 4 therapy therapy NN cord-295206-vetdsk48 181 5 is be VBZ cord-295206-vetdsk48 181 6 central central JJ cord-295206-vetdsk48 181 7 to to IN cord-295206-vetdsk48 181 8 the the DT cord-295206-vetdsk48 181 9 management management NN cord-295206-vetdsk48 181 10 of of IN cord-295206-vetdsk48 181 11 chronic chronic JJ cord-295206-vetdsk48 181 12 bronchitis bronchitis NN cord-295206-vetdsk48 181 13 and and CC cord-295206-vetdsk48 181 14 its -PRON- PRP$ cord-295206-vetdsk48 181 15 acute acute JJ cord-295206-vetdsk48 181 16 exacerbations exacerbation NNS cord-295206-vetdsk48 181 17 Chitkara Chitkara NNP cord-295206-vetdsk48 181 18 and and CC cord-295206-vetdsk48 181 19 Sarinas Sarinas NNP cord-295206-vetdsk48 181 20 ( ( -LRB- cord-295206-vetdsk48 181 21 2002 2002 CD cord-295206-vetdsk48 181 22 ) ) -RRB- cord-295206-vetdsk48 181 23 . . . cord-295206-vetdsk48 182 1 Inhalation inhalation NN cord-295206-vetdsk48 182 2 is be VBZ cord-295206-vetdsk48 182 3 the the DT cord-295206-vetdsk48 182 4 preferred preferred JJ cord-295206-vetdsk48 182 5 route route NN cord-295206-vetdsk48 182 6 of of IN cord-295206-vetdsk48 182 7 administration administration NN cord-295206-vetdsk48 182 8 because because IN cord-295206-vetdsk48 182 9 it -PRON- PRP cord-295206-vetdsk48 182 10 maximizes maximize VBZ cord-295206-vetdsk48 182 11 delivery delivery NN cord-295206-vetdsk48 182 12 of of IN cord-295206-vetdsk48 182 13 the the DT cord-295206-vetdsk48 182 14 agent agent NN cord-295206-vetdsk48 182 15 to to IN cord-295206-vetdsk48 182 16 the the DT cord-295206-vetdsk48 182 17 lungs lung NNS cord-295206-vetdsk48 182 18 and and CC cord-295206-vetdsk48 182 19 minimizes minimize VBZ cord-295206-vetdsk48 182 20 systemic systemic JJ cord-295206-vetdsk48 182 21 side side NN cord-295206-vetdsk48 182 22 effects effect NNS cord-295206-vetdsk48 182 23 . . . cord-295206-vetdsk48 183 1 Anticholinergic Anticholinergic NNP cord-295206-vetdsk48 183 2 bronchodilators bronchodilator NNS cord-295206-vetdsk48 183 3 such such JJ cord-295206-vetdsk48 183 4 as as IN cord-295206-vetdsk48 183 5 ipratropium ipratropium NNP cord-295206-vetdsk48 183 6 block block NN cord-295206-vetdsk48 184 1 the the DT cord-295206-vetdsk48 184 2 muscarinic muscarinic JJ cord-295206-vetdsk48 184 3 receptormediated receptormediate VBN cord-295206-vetdsk48 184 4 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 184 5 , , , cord-295206-vetdsk48 184 6 mucus mucus NN cord-295206-vetdsk48 184 7 secretion secretion NN cord-295206-vetdsk48 184 8 , , , cord-295206-vetdsk48 184 9 and and CC cord-295206-vetdsk48 184 10 bronchial bronchial JJ cord-295206-vetdsk48 184 11 vasodilation vasodilation NN cord-295206-vetdsk48 184 12 that that WDT cord-295206-vetdsk48 184 13 result result VBP cord-295206-vetdsk48 184 14 from from IN cord-295206-vetdsk48 184 15 vagal vagal JJ cord-295206-vetdsk48 184 16 stimulation stimulation NN cord-295206-vetdsk48 184 17 of of IN cord-295206-vetdsk48 184 18 the the DT cord-295206-vetdsk48 184 19 airways airway NNS cord-295206-vetdsk48 184 20 . . . cord-295206-vetdsk48 185 1 The the DT cord-295206-vetdsk48 185 2 duration duration NN cord-295206-vetdsk48 185 3 of of IN cord-295206-vetdsk48 185 4 action action NN cord-295206-vetdsk48 185 5 of of IN cord-295206-vetdsk48 185 6 ipratropium ipratropium NN cord-295206-vetdsk48 185 7 is be VBZ cord-295206-vetdsk48 185 8 longer long JJR cord-295206-vetdsk48 185 9 than than IN cord-295206-vetdsk48 185 10 that that DT cord-295206-vetdsk48 185 11 of of IN cord-295206-vetdsk48 185 12 the the DT cord-295206-vetdsk48 185 13 short short RB cord-295206-vetdsk48 185 14 - - HYPH cord-295206-vetdsk48 185 15 acting act VBG cord-295206-vetdsk48 185 16 beta-2 beta-2 NN cord-295206-vetdsk48 185 17 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 185 18 agonist agonist NN cord-295206-vetdsk48 185 19 bronchodilators bronchodilator NNS cord-295206-vetdsk48 185 20 . . . cord-295206-vetdsk48 186 1 It -PRON- PRP cord-295206-vetdsk48 186 2 can can MD cord-295206-vetdsk48 186 3 decrease decrease VB cord-295206-vetdsk48 186 4 the the DT cord-295206-vetdsk48 186 5 volume volume NN cord-295206-vetdsk48 186 6 of of IN cord-295206-vetdsk48 186 7 sputum sputum NN cord-295206-vetdsk48 186 8 produced produce VBN cord-295206-vetdsk48 186 9 without without IN cord-295206-vetdsk48 186 10 altering alter VBG cord-295206-vetdsk48 186 11 its -PRON- PRP$ cord-295206-vetdsk48 186 12 viscosity viscosity NN cord-295206-vetdsk48 186 13 . . . cord-295206-vetdsk48 187 1 An an DT cord-295206-vetdsk48 187 2 ipratropium ipratropium JJ cord-295206-vetdsk48 187 3 inhaler inhaler NN cord-295206-vetdsk48 187 4 may may MD cord-295206-vetdsk48 187 5 be be VB cord-295206-vetdsk48 187 6 used use VBN cord-295206-vetdsk48 187 7 in in IN cord-295206-vetdsk48 187 8 acute acute JJ cord-295206-vetdsk48 187 9 bronchitis bronchitis NN cord-295206-vetdsk48 187 10 where where WRB cord-295206-vetdsk48 187 11 bronchospasm bronchospasm NN cord-295206-vetdsk48 187 12 is be VBZ cord-295206-vetdsk48 187 13 problematic problematic JJ cord-295206-vetdsk48 187 14 Smuncy Smuncy NNP cord-295206-vetdsk48 187 15 et et FW cord-295206-vetdsk48 187 16 al al NNP cord-295206-vetdsk48 187 17 ( ( -LRB- cord-295206-vetdsk48 187 18 2003 2003 CD cord-295206-vetdsk48 187 19 ) ) -RRB- cord-295206-vetdsk48 187 20 . . . cord-295206-vetdsk48 188 1 In in IN cord-295206-vetdsk48 188 2 chronic chronic JJ cord-295206-vetdsk48 188 3 bronchitis bronchitis NN cord-295206-vetdsk48 188 4 , , , cord-295206-vetdsk48 188 5 ipratropium ipratropium NNP cord-295206-vetdsk48 188 6 is be VBZ cord-295206-vetdsk48 188 7 a a DT cord-295206-vetdsk48 188 8 mainstay mainstay NN cord-295206-vetdsk48 188 9 of of IN cord-295206-vetdsk48 188 10 therapy therapy NN cord-295206-vetdsk48 188 11 Chitkara Chitkara NNP cord-295206-vetdsk48 188 12 and and CC cord-295206-vetdsk48 188 13 Sarinas Sarinas NNP cord-295206-vetdsk48 188 14 ( ( -LRB- cord-295206-vetdsk48 188 15 2002 2002 CD cord-295206-vetdsk48 188 16 ) ) -RRB- cord-295206-vetdsk48 188 17 . . . cord-295206-vetdsk48 189 1 Some some DT cord-295206-vetdsk48 189 2 individuals individual NNS cord-295206-vetdsk48 189 3 who who WP cord-295206-vetdsk48 189 4 are be VBP cord-295206-vetdsk48 189 5 nonresponsive nonresponsive JJ cord-295206-vetdsk48 189 6 to to IN cord-295206-vetdsk48 189 7 beta-2 beta-2 VB cord-295206-vetdsk48 189 8 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 189 9 agonists agonist NNS cord-295206-vetdsk48 189 10 derive derive VBP cord-295206-vetdsk48 189 11 symptomatic symptomatic JJ cord-295206-vetdsk48 189 12 relief relief NN cord-295206-vetdsk48 189 13 with with IN cord-295206-vetdsk48 189 14 ipratropium ipratropium NN cord-295206-vetdsk48 189 15 . . . cord-295206-vetdsk48 190 1 The the DT cord-295206-vetdsk48 190 2 bronchodilatory bronchodilatory JJ cord-295206-vetdsk48 190 3 effect effect NN cord-295206-vetdsk48 190 4 of of IN cord-295206-vetdsk48 190 5 ipratropium ipratropium NN cord-295206-vetdsk48 190 6 is be VBZ cord-295206-vetdsk48 190 7 additive additive NN cord-295206-vetdsk48 190 8 with with IN cord-295206-vetdsk48 190 9 that that DT cord-295206-vetdsk48 190 10 of of IN cord-295206-vetdsk48 190 11 beta-2 beta-2 NN cord-295206-vetdsk48 190 12 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 190 13 agonists agonist NNS cord-295206-vetdsk48 190 14 . . . cord-295206-vetdsk48 191 1 Combination combination NN cord-295206-vetdsk48 191 2 products product NNS cord-295206-vetdsk48 191 3 that that WDT cord-295206-vetdsk48 191 4 deliver deliver VBP cord-295206-vetdsk48 191 5 a a DT cord-295206-vetdsk48 191 6 metered metered JJ cord-295206-vetdsk48 191 7 dose dose NN cord-295206-vetdsk48 191 8 of of IN cord-295206-vetdsk48 191 9 a a DT cord-295206-vetdsk48 191 10 beta-2 beta-2 NN cord-295206-vetdsk48 191 11 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 191 12 agonist agonist NN cord-295206-vetdsk48 191 13 and and CC cord-295206-vetdsk48 191 14 ipratropium ipratropium NNP cord-295206-vetdsk48 191 15 can can MD cord-295206-vetdsk48 191 16 simplify simplify VB cord-295206-vetdsk48 191 17 drug drug NN cord-295206-vetdsk48 191 18 administration administration NN cord-295206-vetdsk48 191 19 . . . cord-295206-vetdsk48 192 1 Although although IN cord-295206-vetdsk48 192 2 chronic chronic JJ cord-295206-vetdsk48 192 3 obstructive obstructive JJ cord-295206-vetdsk48 192 4 pulmonary pulmonary JJ cord-295206-vetdsk48 192 5 disease disease NN cord-295206-vetdsk48 192 6 is be VBZ cord-295206-vetdsk48 192 7 characterized characterize VBN cord-295206-vetdsk48 192 8 by by IN cord-295206-vetdsk48 192 9 bronchoconstriction bronchoconstriction NN cord-295206-vetdsk48 192 10 that that WDT cord-295206-vetdsk48 192 11 is be VBZ cord-295206-vetdsk48 192 12 incompletely incompletely RB cord-295206-vetdsk48 192 13 reversible reversible JJ cord-295206-vetdsk48 192 14 following follow VBG cord-295206-vetdsk48 192 15 administration administration NN cord-295206-vetdsk48 192 16 of of IN cord-295206-vetdsk48 192 17 a a DT cord-295206-vetdsk48 192 18 bronchodilator bronchodilator NN cord-295206-vetdsk48 192 19 , , , cord-295206-vetdsk48 192 20 long long JJ cord-295206-vetdsk48 192 21 - - HYPH cord-295206-vetdsk48 192 22 term term NN cord-295206-vetdsk48 192 23 therapy therapy NN cord-295206-vetdsk48 192 24 with with IN cord-295206-vetdsk48 192 25 bronchodilators bronchodilator NNS cord-295206-vetdsk48 192 26 decreases decrease VBZ cord-295206-vetdsk48 192 27 the the DT cord-295206-vetdsk48 192 28 symptoms symptom NNS cord-295206-vetdsk48 192 29 of of IN cord-295206-vetdsk48 192 30 airflow airflow NN cord-295206-vetdsk48 192 31 limitation limitation NN cord-295206-vetdsk48 192 32 in in IN cord-295206-vetdsk48 192 33 individuals individual NNS cord-295206-vetdsk48 192 34 with with IN cord-295206-vetdsk48 192 35 chronic chronic JJ cord-295206-vetdsk48 192 36 bronchitis bronchitis NN cord-295206-vetdsk48 192 37 . . . cord-295206-vetdsk48 193 1 Thus thus RB cord-295206-vetdsk48 193 2 , , , cord-295206-vetdsk48 193 3 bronchodilator bronchodilator NN cord-295206-vetdsk48 193 4 therapy therapy NN cord-295206-vetdsk48 193 5 is be VBZ cord-295206-vetdsk48 193 6 central central JJ cord-295206-vetdsk48 193 7 to to IN cord-295206-vetdsk48 193 8 the the DT cord-295206-vetdsk48 193 9 management management NN cord-295206-vetdsk48 193 10 of of IN cord-295206-vetdsk48 193 11 chronic chronic JJ cord-295206-vetdsk48 193 12 bronchitis bronchitis NN cord-295206-vetdsk48 193 13 and and CC cord-295206-vetdsk48 193 14 its -PRON- PRP$ cord-295206-vetdsk48 193 15 acute acute JJ cord-295206-vetdsk48 193 16 exacerbations exacerbation NNS cord-295206-vetdsk48 193 17 Chitkara Chitkara NNP cord-295206-vetdsk48 193 18 and and CC cord-295206-vetdsk48 193 19 Sarinas Sarinas NNP cord-295206-vetdsk48 193 20 ( ( -LRB- cord-295206-vetdsk48 193 21 2002 2002 CD cord-295206-vetdsk48 193 22 ) ) -RRB- cord-295206-vetdsk48 193 23 . . . cord-295206-vetdsk48 194 1 Theophylline theophylline NN cord-295206-vetdsk48 194 2 exerts exert VBZ cord-295206-vetdsk48 194 3 a a DT cord-295206-vetdsk48 194 4 wide wide JJ cord-295206-vetdsk48 194 5 variety variety NN cord-295206-vetdsk48 194 6 of of IN cord-295206-vetdsk48 194 7 physiological physiological JJ cord-295206-vetdsk48 194 8 actions action NNS cord-295206-vetdsk48 194 9 including include VBG cord-295206-vetdsk48 194 10 central central JJ cord-295206-vetdsk48 194 11 nervous nervous JJ cord-295206-vetdsk48 194 12 system system NN cord-295206-vetdsk48 194 13 stimulation stimulation NN cord-295206-vetdsk48 194 14 , , , cord-295206-vetdsk48 194 15 cardiac cardiac JJ cord-295206-vetdsk48 194 16 stimulation stimulation NN cord-295206-vetdsk48 194 17 , , , cord-295206-vetdsk48 194 18 and and CC cord-295206-vetdsk48 194 19 smooth smooth JJ cord-295206-vetdsk48 194 20 muscle muscle NN cord-295206-vetdsk48 194 21 relaxation relaxation NN cord-295206-vetdsk48 194 22 . . . cord-295206-vetdsk48 195 1 Its -PRON- PRP$ cord-295206-vetdsk48 195 2 major major JJ cord-295206-vetdsk48 195 3 action action NN cord-295206-vetdsk48 195 4 on on IN cord-295206-vetdsk48 195 5 the the DT cord-295206-vetdsk48 195 6 lung lung NN cord-295206-vetdsk48 195 7 results result NNS cord-295206-vetdsk48 195 8 from from IN cord-295206-vetdsk48 195 9 the the DT cord-295206-vetdsk48 195 10 inhibition inhibition NN cord-295206-vetdsk48 195 11 of of IN cord-295206-vetdsk48 195 12 the the DT cord-295206-vetdsk48 195 13 cyclic cyclic JJ cord-295206-vetdsk48 195 14 nucleotide nucleotide JJ cord-295206-vetdsk48 195 15 phosphodiesterases phosphodiesterase NNS cord-295206-vetdsk48 195 16 that that WDT cord-295206-vetdsk48 195 17 break break VBP cord-295206-vetdsk48 195 18 down down RP cord-295206-vetdsk48 195 19 cyclic cyclic JJ cord-295206-vetdsk48 195 20 AMP AMP NNP cord-295206-vetdsk48 195 21 and and CC cord-295206-vetdsk48 195 22 cGMP cGMP NNP cord-295206-vetdsk48 195 23 , , , cord-295206-vetdsk48 195 24 second second JJ cord-295206-vetdsk48 195 25 messengers messenger NNS cord-295206-vetdsk48 195 26 that that WDT cord-295206-vetdsk48 195 27 mediate mediate VBP cord-295206-vetdsk48 195 28 bronchodilation bronchodilation NN cord-295206-vetdsk48 195 29 . . . cord-295206-vetdsk48 196 1 Theophylline theophylline NN cord-295206-vetdsk48 196 2 also also RB cord-295206-vetdsk48 196 3 inhibits inhibit VBZ cord-295206-vetdsk48 196 4 the the DT cord-295206-vetdsk48 196 5 release release NN cord-295206-vetdsk48 196 6 of of IN cord-295206-vetdsk48 196 7 inflammatory inflammatory JJ cord-295206-vetdsk48 196 8 mediators mediator NNS cord-295206-vetdsk48 196 9 by by IN cord-295206-vetdsk48 196 10 immune immune JJ cord-295206-vetdsk48 196 11 cells cell NNS cord-295206-vetdsk48 196 12 . . . cord-295206-vetdsk48 197 1 Its -PRON- PRP$ cord-295206-vetdsk48 197 2 narrow narrow JJ cord-295206-vetdsk48 197 3 therapeutic therapeutic JJ cord-295206-vetdsk48 197 4 index index NN cord-295206-vetdsk48 197 5 , , , cord-295206-vetdsk48 197 6 potentially potentially RB cord-295206-vetdsk48 197 7 life life NN cord-295206-vetdsk48 197 8 - - HYPH cord-295206-vetdsk48 197 9 threatening threaten VBG cord-295206-vetdsk48 197 10 side side NN cord-295206-vetdsk48 197 11 effects effect NNS cord-295206-vetdsk48 197 12 , , , cord-295206-vetdsk48 197 13 and and CC cord-295206-vetdsk48 197 14 numerous numerous JJ cord-295206-vetdsk48 197 15 drug drug NN cord-295206-vetdsk48 197 16 interactions interaction NNS cord-295206-vetdsk48 197 17 have have VBP cord-295206-vetdsk48 197 18 made make VBN cord-295206-vetdsk48 197 19 theophylline theophylline NN cord-295206-vetdsk48 197 20 a a DT cord-295206-vetdsk48 197 21 second second JJ cord-295206-vetdsk48 197 22 - - HYPH cord-295206-vetdsk48 197 23 line line NN cord-295206-vetdsk48 197 24 therapy therapy NN cord-295206-vetdsk48 197 25 for for IN cord-295206-vetdsk48 197 26 chronic chronic JJ cord-295206-vetdsk48 197 27 bronchitis bronchitis NN cord-295206-vetdsk48 197 28 . . . cord-295206-vetdsk48 198 1 While while IN cord-295206-vetdsk48 198 2 its -PRON- PRP$ cord-295206-vetdsk48 198 3 efficacy efficacy NN cord-295206-vetdsk48 198 4 as as IN cord-295206-vetdsk48 198 5 compared compare VBN cord-295206-vetdsk48 198 6 to to IN cord-295206-vetdsk48 198 7 other other JJ cord-295206-vetdsk48 198 8 bronchodilators bronchodilator NNS cord-295206-vetdsk48 198 9 is be VBZ cord-295206-vetdsk48 198 10 questionable questionable JJ cord-295206-vetdsk48 198 11 , , , cord-295206-vetdsk48 198 12 a a DT cord-295206-vetdsk48 198 13 subset subset NN cord-295206-vetdsk48 198 14 of of IN cord-295206-vetdsk48 198 15 patients patient NNS cord-295206-vetdsk48 198 16 appears appear VBZ cord-295206-vetdsk48 198 17 to to TO cord-295206-vetdsk48 198 18 benefit benefit VB cord-295206-vetdsk48 198 19 from from IN cord-295206-vetdsk48 198 20 theophylline theophylline NN cord-295206-vetdsk48 198 21 . . . cord-295206-vetdsk48 199 1 Lower low JJR cord-295206-vetdsk48 199 2 therapeutic therapeutic JJ cord-295206-vetdsk48 199 3 doses dose NNS cord-295206-vetdsk48 199 4 used use VBN cord-295206-vetdsk48 199 5 in in IN cord-295206-vetdsk48 199 6 combination combination NN cord-295206-vetdsk48 199 7 with with IN cord-295206-vetdsk48 199 8 a a DT cord-295206-vetdsk48 199 9 beta-2 beta-2 NN cord-295206-vetdsk48 199 10 adrenoceptor adrenoceptor NN cord-295206-vetdsk48 199 11 agonist agonist NN cord-295206-vetdsk48 199 12 may may MD cord-295206-vetdsk48 199 13 be be VB cord-295206-vetdsk48 199 14 beneficial beneficial JJ cord-295206-vetdsk48 199 15 in in IN cord-295206-vetdsk48 199 16 some some DT cord-295206-vetdsk48 199 17 cases case NNS cord-295206-vetdsk48 199 18 . . . cord-295206-vetdsk48 200 1 Oxygen oxygen NN cord-295206-vetdsk48 200 2 Oxygen oxygen NN cord-295206-vetdsk48 200 3 therapy therapy NN cord-295206-vetdsk48 200 4 is be VBZ cord-295206-vetdsk48 200 5 indicated indicate VBN cord-295206-vetdsk48 200 6 when when WRB cord-295206-vetdsk48 200 7 the the DT cord-295206-vetdsk48 200 8 symptoms symptom NNS cord-295206-vetdsk48 200 9 of of IN cord-295206-vetdsk48 200 10 chronic chronic JJ cord-295206-vetdsk48 200 11 obstructive obstructive JJ cord-295206-vetdsk48 200 12 pulmonary pulmonary JJ cord-295206-vetdsk48 200 13 disease disease NN cord-295206-vetdsk48 200 14 ( ( -LRB- cord-295206-vetdsk48 200 15 COPD COPD NNP cord-295206-vetdsk48 200 16 ) ) -RRB- cord-295206-vetdsk48 200 17 become become VBP cord-295206-vetdsk48 200 18 severe severe JJ cord-295206-vetdsk48 200 19 enough enough RB cord-295206-vetdsk48 200 20 to to TO cord-295206-vetdsk48 200 21 limit limit VB cord-295206-vetdsk48 200 22 activities activity NNS cord-295206-vetdsk48 200 23 of of IN cord-295206-vetdsk48 200 24 daily daily JJ cord-295206-vetdsk48 200 25 living live VBG cord-295206-vetdsk48 200 26 Chitkara Chitkara NNP cord-295206-vetdsk48 200 27 and and CC cord-295206-vetdsk48 200 28 Sarinas Sarinas NNP cord-295206-vetdsk48 200 29 ( ( -LRB- cord-295206-vetdsk48 200 30 2002 2002 CD cord-295206-vetdsk48 200 31 ) ) -RRB- cord-295206-vetdsk48 200 32 . . . cord-295206-vetdsk48 201 1 It -PRON- PRP cord-295206-vetdsk48 201 2 may may MD cord-295206-vetdsk48 201 3 also also RB cord-295206-vetdsk48 201 4 be be VB cord-295206-vetdsk48 201 5 used use VBN cord-295206-vetdsk48 201 6 as as IN cord-295206-vetdsk48 201 7 - - HYPH cord-295206-vetdsk48 201 8 needed need VBN cord-295206-vetdsk48 201 9 during during IN cord-295206-vetdsk48 201 10 exercise exercise NN cord-295206-vetdsk48 201 11 in in IN cord-295206-vetdsk48 201 12 those those DT cord-295206-vetdsk48 201 13 who who WP cord-295206-vetdsk48 201 14 do do VBP cord-295206-vetdsk48 201 15 n't not RB cord-295206-vetdsk48 201 16 qualify qualify VB cord-295206-vetdsk48 201 17 for for IN cord-295206-vetdsk48 201 18 continuous continuous JJ cord-295206-vetdsk48 201 19 oxygen oxygen NN cord-295206-vetdsk48 201 20 use use NN cord-295206-vetdsk48 201 21 . . . cord-295206-vetdsk48 202 1 Oxygen oxygen NN cord-295206-vetdsk48 202 2 therapy therapy NN cord-295206-vetdsk48 202 3 reduces reduce VBZ cord-295206-vetdsk48 202 4 mortality mortality NN cord-295206-vetdsk48 202 5 and and CC cord-295206-vetdsk48 202 6 improves improve VBZ cord-295206-vetdsk48 202 7 quality quality NN cord-295206-vetdsk48 202 8 of of IN cord-295206-vetdsk48 202 9 life life NN cord-295206-vetdsk48 202 10 in in IN cord-295206-vetdsk48 202 11 persons person NNS cord-295206-vetdsk48 202 12 with with IN cord-295206-vetdsk48 202 13 severe severe JJ cord-295206-vetdsk48 202 14 COP cop NN cord-295206-vetdsk48 202 15 D. D. NNP cord-295206-vetdsk48 203 1 It -PRON- PRP cord-295206-vetdsk48 203 2 is be VBZ cord-295206-vetdsk48 203 3 also also RB cord-295206-vetdsk48 203 4 useful useful JJ cord-295206-vetdsk48 203 5 in in IN cord-295206-vetdsk48 203 6 the the DT cord-295206-vetdsk48 203 7 management management NN cord-295206-vetdsk48 203 8 of of IN cord-295206-vetdsk48 203 9 acute acute JJ cord-295206-vetdsk48 203 10 exacerbations exacerbation NNS cord-295206-vetdsk48 203 11 of of IN cord-295206-vetdsk48 203 12 chronic chronic JJ cord-295206-vetdsk48 203 13 bronchitis bronchitis NN cord-295206-vetdsk48 203 14 McCrory McCrory NNP cord-295206-vetdsk48 203 15 et et NNP cord-295206-vetdsk48 203 16 al al NNP cord-295206-vetdsk48 203 17 ( ( -LRB- cord-295206-vetdsk48 203 18 2001 2001 CD cord-295206-vetdsk48 203 19 ) ) -RRB- cord-295206-vetdsk48 203 20 . . . cord-295206-vetdsk48 204 1 Antibiotics antibiotic NNS cord-295206-vetdsk48 205 1 Although although IN cord-295206-vetdsk48 205 2 antibiotics antibiotic NNS cord-295206-vetdsk48 205 3 are be VBP cord-295206-vetdsk48 205 4 frequently frequently RB cord-295206-vetdsk48 205 5 prescribed prescribe VBN cord-295206-vetdsk48 205 6 for for IN cord-295206-vetdsk48 205 7 acute acute JJ cord-295206-vetdsk48 205 8 bronchitis bronchitis NN cord-295206-vetdsk48 205 9 , , , cord-295206-vetdsk48 205 10 most most JJS cord-295206-vetdsk48 205 11 cases case NNS cord-295206-vetdsk48 205 12 are be VBP cord-295206-vetdsk48 205 13 viral viral JJ cord-295206-vetdsk48 205 14 in in IN cord-295206-vetdsk48 205 15 origin origin NN cord-295206-vetdsk48 205 16 , , , cord-295206-vetdsk48 205 17 rendering render VBG cord-295206-vetdsk48 205 18 them -PRON- PRP cord-295206-vetdsk48 205 19 useless useless JJ cord-295206-vetdsk48 205 20 . . . cord-295206-vetdsk48 206 1 Antibiotic antibiotic JJ cord-295206-vetdsk48 206 2 therapy therapy NN cord-295206-vetdsk48 206 3 does do VBZ cord-295206-vetdsk48 206 4 not not RB cord-295206-vetdsk48 206 5 decrease decrease VB cord-295206-vetdsk48 206 6 the the DT cord-295206-vetdsk48 206 7 duration duration NN cord-295206-vetdsk48 206 8 of of IN cord-295206-vetdsk48 206 9 illness illness NN cord-295206-vetdsk48 206 10 , , , cord-295206-vetdsk48 206 11 limitation limitation NN cord-295206-vetdsk48 206 12 of of IN cord-295206-vetdsk48 206 13 activities activity NNS cord-295206-vetdsk48 206 14 , , , cord-295206-vetdsk48 206 15 or or CC cord-295206-vetdsk48 206 16 loss loss NN cord-295206-vetdsk48 206 17 of of IN cord-295206-vetdsk48 206 18 work work NN cord-295206-vetdsk48 206 19 time time NN cord-295206-vetdsk48 206 20 in in IN cord-295206-vetdsk48 206 21 most most JJS cord-295206-vetdsk48 206 22 cases case NNS cord-295206-vetdsk48 206 23 of of IN cord-295206-vetdsk48 206 24 acute acute JJ cord-295206-vetdsk48 206 25 bronchitis bronchitis NN cord-295206-vetdsk48 206 26 Fahey Fahey NNP cord-295206-vetdsk48 206 27 et et NNP cord-295206-vetdsk48 206 28 al al NNP cord-295206-vetdsk48 206 29 ( ( -LRB- cord-295206-vetdsk48 206 30 1998 1998 CD cord-295206-vetdsk48 206 31 ) ) -RRB- cord-295206-vetdsk48 206 32 , , , cord-295206-vetdsk48 206 33 Smuncy Smuncy NNP cord-295206-vetdsk48 206 34 et et NNP cord-295206-vetdsk48 206 35 al al NNP cord-295206-vetdsk48 206 36 ( ( -LRB- cord-295206-vetdsk48 206 37 1998 1998 CD cord-295206-vetdsk48 206 38 , , , cord-295206-vetdsk48 206 39 Bent Bent NNP cord-295206-vetdsk48 206 40 et et FW cord-295206-vetdsk48 206 41 al al NNP cord-295206-vetdsk48 206 42 ( ( -LRB- cord-295206-vetdsk48 206 43 1999 1999 CD cord-295206-vetdsk48 206 44 ) ) -RRB- cord-295206-vetdsk48 206 45 . . . cord-295206-vetdsk48 207 1 Thus thus RB cord-295206-vetdsk48 207 2 , , , cord-295206-vetdsk48 207 3 the the DT cord-295206-vetdsk48 207 4 frequency frequency NN cord-295206-vetdsk48 207 5 of of IN cord-295206-vetdsk48 207 6 antibiotic antibiotic JJ cord-295206-vetdsk48 207 7 use use NN cord-295206-vetdsk48 207 8 can can MD cord-295206-vetdsk48 207 9 safely safely RB cord-295206-vetdsk48 207 10 be be VB cord-295206-vetdsk48 207 11 reduced reduce VBN cord-295206-vetdsk48 207 12 without without IN cord-295206-vetdsk48 207 13 affecting affect VBG cord-295206-vetdsk48 207 14 patient patient NN cord-295206-vetdsk48 207 15 outcomes outcome NNS cord-295206-vetdsk48 207 16 Gonzales Gonzales NNP cord-295206-vetdsk48 207 17 et et NNP cord-295206-vetdsk48 207 18 al al NNP cord-295206-vetdsk48 207 19 ( ( -LRB- cord-295206-vetdsk48 207 20 2001 2001 CD cord-295206-vetdsk48 207 21 ) ) -RRB- cord-295206-vetdsk48 207 22 . . . cord-295206-vetdsk48 208 1 In in IN cord-295206-vetdsk48 208 2 the the DT cord-295206-vetdsk48 208 3 rare rare JJ cord-295206-vetdsk48 208 4 cases case NNS cord-295206-vetdsk48 208 5 in in IN cord-295206-vetdsk48 208 6 which which WDT cord-295206-vetdsk48 208 7 acute acute JJ cord-295206-vetdsk48 208 8 bronchitis bronchitis NN cord-295206-vetdsk48 208 9 is be VBZ cord-295206-vetdsk48 208 10 caused cause VBN cord-295206-vetdsk48 208 11 by by IN cord-295206-vetdsk48 208 12 Mycoplasma mycoplasma NN cord-295206-vetdsk48 208 13 pneumoniae pneumoniae NNS cord-295206-vetdsk48 208 14 or or CC cord-295206-vetdsk48 208 15 Chlamydia Chlamydia NNP cord-295206-vetdsk48 208 16 pneumoniae pneumoniae NN cord-295206-vetdsk48 208 17 , , , cord-295206-vetdsk48 208 18 fluoroquinolones fluoroquinolone NNS cord-295206-vetdsk48 208 19 , , , cord-295206-vetdsk48 208 20 tetracycline tetracycline NN cord-295206-vetdsk48 208 21 , , , cord-295206-vetdsk48 208 22 and and CC cord-295206-vetdsk48 208 23 macrolides macrolide NNS cord-295206-vetdsk48 208 24 are be VBP cord-295206-vetdsk48 208 25 effective effective JJ cord-295206-vetdsk48 208 26 Gonzales Gonzales NNP cord-295206-vetdsk48 208 27 and and CC cord-295206-vetdsk48 208 28 Sande Sande NNP cord-295206-vetdsk48 208 29 ( ( -LRB- cord-295206-vetdsk48 208 30 2000 2000 CD cord-295206-vetdsk48 208 31 ) ) -RRB- cord-295206-vetdsk48 208 32 . . . cord-295206-vetdsk48 209 1 Acute acute JJ cord-295206-vetdsk48 209 2 bronchitis bronchitis NN cord-295206-vetdsk48 209 3 caused cause VBN cord-295206-vetdsk48 209 4 by by IN cord-295206-vetdsk48 209 5 Bordetella Bordetella NNP cord-295206-vetdsk48 209 6 pertussis pertussis NN cord-295206-vetdsk48 209 7 may may MD cord-295206-vetdsk48 209 8 be be VB cord-295206-vetdsk48 209 9 treated treat VBN cord-295206-vetdsk48 209 10 with with IN cord-295206-vetdsk48 209 11 erythromycin erythromycin NN cord-295206-vetdsk48 209 12 , , , cord-295206-vetdsk48 209 13 but but CC cord-295206-vetdsk48 209 14 it -PRON- PRP cord-295206-vetdsk48 209 15 is be VBZ cord-295206-vetdsk48 209 16 only only RB cord-295206-vetdsk48 209 17 effective effective JJ cord-295206-vetdsk48 209 18 early early RB cord-295206-vetdsk48 209 19 in in IN cord-295206-vetdsk48 209 20 the the DT cord-295206-vetdsk48 209 21 course course NN cord-295206-vetdsk48 209 22 of of IN cord-295206-vetdsk48 209 23 illness illness NN cord-295206-vetdsk48 209 24 . . . cord-295206-vetdsk48 210 1 The the DT cord-295206-vetdsk48 210 2 role role NN cord-295206-vetdsk48 210 3 of of IN cord-295206-vetdsk48 210 4 bacterial bacterial JJ cord-295206-vetdsk48 210 5 infection infection NN cord-295206-vetdsk48 210 6 in in IN cord-295206-vetdsk48 210 7 acute acute JJ cord-295206-vetdsk48 210 8 exacerbation exacerbation NN cord-295206-vetdsk48 210 9 of of IN cord-295206-vetdsk48 210 10 chronic chronic JJ cord-295206-vetdsk48 210 11 bronchitis bronchitis NN cord-295206-vetdsk48 210 12 remains remain VBZ cord-295206-vetdsk48 210 13 controversial controversial JJ cord-295206-vetdsk48 210 14 . . . cord-295206-vetdsk48 211 1 In in IN cord-295206-vetdsk48 211 2 those those DT cord-295206-vetdsk48 211 3 exacerbations exacerbation NNS cord-295206-vetdsk48 211 4 in in IN cord-295206-vetdsk48 211 5 which which WDT cord-295206-vetdsk48 211 6 purulent purulent JJ cord-295206-vetdsk48 211 7 sputum sputum NN cord-295206-vetdsk48 211 8 is be VBZ cord-295206-vetdsk48 211 9 a a DT cord-295206-vetdsk48 211 10 predominant predominant JJ cord-295206-vetdsk48 211 11 feature feature NN cord-295206-vetdsk48 211 12 , , , cord-295206-vetdsk48 211 13 the the DT cord-295206-vetdsk48 211 14 extent extent NN cord-295206-vetdsk48 211 15 of of IN cord-295206-vetdsk48 211 16 bacterial bacterial JJ cord-295206-vetdsk48 211 17 eradication eradication NN cord-295206-vetdsk48 211 18 correlates correlate VBZ cord-295206-vetdsk48 211 19 with with IN cord-295206-vetdsk48 211 20 the the DT cord-295206-vetdsk48 211 21 degree degree NN cord-295206-vetdsk48 211 22 of of IN cord-295206-vetdsk48 211 23 resolution resolution NN cord-295206-vetdsk48 211 24 of of IN cord-295206-vetdsk48 211 25 inflammation inflammation NN cord-295206-vetdsk48 211 26 associated associate VBN cord-295206-vetdsk48 211 27 with with IN cord-295206-vetdsk48 211 28 the the DT cord-295206-vetdsk48 211 29 exacerbation exacerbation NN cord-295206-vetdsk48 211 30 White White NNP cord-295206-vetdsk48 211 31 et et FW cord-295206-vetdsk48 211 32 al al NNP cord-295206-vetdsk48 211 33 ( ( -LRB- cord-295206-vetdsk48 211 34 2003 2003 CD cord-295206-vetdsk48 211 35 ) ) -RRB- cord-295206-vetdsk48 211 36 . . . cord-295206-vetdsk48 212 1 The the DT cord-295206-vetdsk48 212 2 United United NNP cord-295206-vetdsk48 212 3 States States NNP cord-295206-vetdsk48 212 4 National National NNP cord-295206-vetdsk48 212 5 Heart Heart NNP cord-295206-vetdsk48 212 6 , , , cord-295206-vetdsk48 212 7 Lung Lung NNP cord-295206-vetdsk48 212 8 , , , cord-295206-vetdsk48 212 9 and and CC cord-295206-vetdsk48 212 10 Blood Blood NNP cord-295206-vetdsk48 212 11 Institute Institute NNP cord-295206-vetdsk48 212 12 and and CC cord-295206-vetdsk48 212 13 the the DT cord-295206-vetdsk48 212 14 World World NNP cord-295206-vetdsk48 212 15 Health Health NNP cord-295206-vetdsk48 212 16 Organization Organization NNP cord-295206-vetdsk48 212 17 recommended recommend VBD cord-295206-vetdsk48 212 18 that that IN cord-295206-vetdsk48 212 19 antibiotics antibiotic NNS cord-295206-vetdsk48 212 20 be be VB cord-295206-vetdsk48 212 21 given give VBN cord-295206-vetdsk48 212 22 for for IN cord-295206-vetdsk48 212 23 acute acute JJ cord-295206-vetdsk48 212 24 exacerbations exacerbation NNS cord-295206-vetdsk48 212 25 in in IN cord-295206-vetdsk48 212 26 which which WDT cord-295206-vetdsk48 212 27 there there EX cord-295206-vetdsk48 212 28 is be VBZ cord-295206-vetdsk48 212 29 evidence evidence NN cord-295206-vetdsk48 212 30 of of IN cord-295206-vetdsk48 212 31 infection infection NN cord-295206-vetdsk48 212 32 , , , cord-295206-vetdsk48 212 33 e.g. e.g. RB cord-295206-vetdsk48 212 34 increased increase VBN cord-295206-vetdsk48 212 35 sputum sputum NN cord-295206-vetdsk48 212 36 production production NN cord-295206-vetdsk48 212 37 , , , cord-295206-vetdsk48 212 38 change change VBP cord-295206-vetdsk48 212 39 in in IN cord-295206-vetdsk48 212 40 sputum sputum NN cord-295206-vetdsk48 212 41 color color NN cord-295206-vetdsk48 212 42 , , , cord-295206-vetdsk48 212 43 and/or and/or CC cord-295206-vetdsk48 212 44 fever fever NN cord-295206-vetdsk48 212 45 Pauwels Pauwels NNP cord-295206-vetdsk48 212 46 et et NNP cord-295206-vetdsk48 212 47 al al NNP cord-295206-vetdsk48 212 48 ( ( -LRB- cord-295206-vetdsk48 212 49 2001 2001 CD cord-295206-vetdsk48 212 50 ) ) -RRB- cord-295206-vetdsk48 212 51 . . . cord-295206-vetdsk48 213 1 Commonly commonly RB cord-295206-vetdsk48 213 2 used use VBN cord-295206-vetdsk48 213 3 antibiotics antibiotic NNS cord-295206-vetdsk48 213 4 include include VBP cord-295206-vetdsk48 213 5 amoxicillin amoxicillin NNP cord-295206-vetdsk48 213 6 - - HYPH cord-295206-vetdsk48 213 7 clavulanate clavulanate NNP cord-295206-vetdsk48 213 8 , , , cord-295206-vetdsk48 213 9 azithromycin azithromycin NNP cord-295206-vetdsk48 213 10 , , , cord-295206-vetdsk48 213 11 and and CC cord-295206-vetdsk48 213 12 several several JJ cord-295206-vetdsk48 213 13 cephalosporins cephalosporin NNS cord-295206-vetdsk48 213 14 and and CC cord-295206-vetdsk48 213 15 fluoroquinolones fluoroquinolone NNS cord-295206-vetdsk48 213 16 . . . cord-295206-vetdsk48 214 1 Although although IN cord-295206-vetdsk48 214 2 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 214 3 are be VBP cord-295206-vetdsk48 214 4 frequently frequently RB cord-295206-vetdsk48 214 5 employed employ VBN cord-295206-vetdsk48 214 6 in in IN cord-295206-vetdsk48 214 7 the the DT cord-295206-vetdsk48 214 8 therapy therapy NN cord-295206-vetdsk48 214 9 of of IN cord-295206-vetdsk48 214 10 chronic chronic JJ cord-295206-vetdsk48 214 11 bronchitis bronchitis NN cord-295206-vetdsk48 214 12 , , , cord-295206-vetdsk48 214 13 their -PRON- PRP$ cord-295206-vetdsk48 214 14 use use NN cord-295206-vetdsk48 214 15 is be VBZ cord-295206-vetdsk48 214 16 controversial controversial JJ cord-295206-vetdsk48 214 17 Chitkara Chitkara NNP cord-295206-vetdsk48 214 18 and and CC cord-295206-vetdsk48 214 19 Sarinas Sarinas NNP cord-295206-vetdsk48 214 20 ( ( -LRB- cord-295206-vetdsk48 214 21 2002 2002 CD cord-295206-vetdsk48 214 22 ) ) -RRB- cord-295206-vetdsk48 214 23 . . . cord-295206-vetdsk48 215 1 Glucocorticoids Glucocorticoids NNP cord-295206-vetdsk48 215 2 block block NN cord-295206-vetdsk48 215 3 immune immune JJ cord-295206-vetdsk48 215 4 cell cell NN cord-295206-vetdsk48 215 5 activation activation NN cord-295206-vetdsk48 215 6 , , , cord-295206-vetdsk48 215 7 cytokine cytokine NN cord-295206-vetdsk48 215 8 release release NN cord-295206-vetdsk48 215 9 , , , cord-295206-vetdsk48 215 10 and and CC cord-295206-vetdsk48 215 11 mucus mucus NN cord-295206-vetdsk48 215 12 secretion secretion NN cord-295206-vetdsk48 215 13 in in IN cord-295206-vetdsk48 215 14 vitro vitro FW cord-295206-vetdsk48 215 15 , , , cord-295206-vetdsk48 215 16 yet yet CC cord-295206-vetdsk48 215 17 only only RB cord-295206-vetdsk48 215 18 10 10 CD cord-295206-vetdsk48 215 19 - - SYM cord-295206-vetdsk48 215 20 20 20 CD cord-295206-vetdsk48 215 21 % % NN cord-295206-vetdsk48 215 22 of of IN cord-295206-vetdsk48 215 23 individuals individual NNS cord-295206-vetdsk48 215 24 with with IN cord-295206-vetdsk48 215 25 chronic chronic JJ cord-295206-vetdsk48 215 26 obstructive obstructive JJ cord-295206-vetdsk48 215 27 pulmonary pulmonary JJ cord-295206-vetdsk48 215 28 disease disease NN cord-295206-vetdsk48 215 29 actually actually RB cord-295206-vetdsk48 215 30 respond respond VBZ cord-295206-vetdsk48 215 31 to to IN cord-295206-vetdsk48 215 32 them -PRON- PRP cord-295206-vetdsk48 215 33 . . . cord-295206-vetdsk48 216 1 It -PRON- PRP cord-295206-vetdsk48 216 2 is be VBZ cord-295206-vetdsk48 216 3 impossible impossible JJ cord-295206-vetdsk48 216 4 to to TO cord-295206-vetdsk48 216 5 predict predict VB cord-295206-vetdsk48 216 6 who who WP cord-295206-vetdsk48 216 7 will will MD cord-295206-vetdsk48 216 8 respond respond VB cord-295206-vetdsk48 216 9 to to IN cord-295206-vetdsk48 216 10 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 216 11 . . . cord-295206-vetdsk48 217 1 Indeed indeed RB cord-295206-vetdsk48 217 2 , , , cord-295206-vetdsk48 217 3 those those DT cord-295206-vetdsk48 217 4 who who WP cord-295206-vetdsk48 217 5 benefit benefit VBP cord-295206-vetdsk48 217 6 from from IN cord-295206-vetdsk48 217 7 oral oral JJ cord-295206-vetdsk48 217 8 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 217 9 during during IN cord-295206-vetdsk48 217 10 acute acute JJ cord-295206-vetdsk48 217 11 exacerbations exacerbation NNS cord-295206-vetdsk48 217 12 may may MD cord-295206-vetdsk48 217 13 not not RB cord-295206-vetdsk48 217 14 realize realize VB cord-295206-vetdsk48 217 15 any any DT cord-295206-vetdsk48 217 16 value value NN cord-295206-vetdsk48 217 17 from from IN cord-295206-vetdsk48 217 18 chronic chronic JJ cord-295206-vetdsk48 217 19 inhaled inhale VBN cord-295206-vetdsk48 217 20 glucocorticoid glucocorticoid NN cord-295206-vetdsk48 217 21 use use NN cord-295206-vetdsk48 217 22 . . . cord-295206-vetdsk48 218 1 Systemic systemic JJ cord-295206-vetdsk48 218 2 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 218 3 ( ( -LRB- cord-295206-vetdsk48 218 4 e.g. e.g. RB cord-295206-vetdsk48 218 5 , , , cord-295206-vetdsk48 218 6 prednisolone prednisolone NN cord-295206-vetdsk48 218 7 ) ) -RRB- cord-295206-vetdsk48 218 8 are be VBP cord-295206-vetdsk48 218 9 used use VBN cord-295206-vetdsk48 218 10 for for IN cord-295206-vetdsk48 218 11 the the DT cord-295206-vetdsk48 218 12 treatment treatment NN cord-295206-vetdsk48 218 13 of of IN cord-295206-vetdsk48 218 14 acute acute JJ cord-295206-vetdsk48 218 15 exacerbations exacerbation NNS cord-295206-vetdsk48 218 16 of of IN cord-295206-vetdsk48 218 17 chronic chronic JJ cord-295206-vetdsk48 218 18 bronchitis bronchitis NN cord-295206-vetdsk48 218 19 and and CC cord-295206-vetdsk48 218 20 can can MD cord-295206-vetdsk48 218 21 alleviate alleviate VB cord-295206-vetdsk48 218 22 symptoms symptom NNS cord-295206-vetdsk48 218 23 , , , cord-295206-vetdsk48 218 24 decrease decrease VB cord-295206-vetdsk48 218 25 hospitalization hospitalization NN cord-295206-vetdsk48 218 26 time time NN cord-295206-vetdsk48 218 27 , , , cord-295206-vetdsk48 218 28 and and CC cord-295206-vetdsk48 218 29 reduce reduce VB cord-295206-vetdsk48 218 30 relapse relapse NN cord-295206-vetdsk48 218 31 rate rate NN cord-295206-vetdsk48 218 32 among among IN cord-295206-vetdsk48 218 33 steroid steroid NN cord-295206-vetdsk48 218 34 - - HYPH cord-295206-vetdsk48 218 35 responsive responsive JJ cord-295206-vetdsk48 218 36 individuals individual NNS cord-295206-vetdsk48 218 37 McCrory McCrory NNP cord-295206-vetdsk48 218 38 et et NNP cord-295206-vetdsk48 218 39 al al NNP cord-295206-vetdsk48 218 40 ( ( -LRB- cord-295206-vetdsk48 218 41 2001 2001 CD cord-295206-vetdsk48 218 42 ) ) -RRB- cord-295206-vetdsk48 218 43 . . . cord-295206-vetdsk48 219 1 Chronic chronic JJ cord-295206-vetdsk48 219 2 treatment treatment NN cord-295206-vetdsk48 219 3 with with IN cord-295206-vetdsk48 219 4 inhaled inhale VBN cord-295206-vetdsk48 219 5 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 219 6 such such JJ cord-295206-vetdsk48 219 7 as as IN cord-295206-vetdsk48 219 8 fluticasone fluticasone NN cord-295206-vetdsk48 219 9 produces produce VBZ cord-295206-vetdsk48 219 10 a a DT cord-295206-vetdsk48 219 11 modest modest JJ cord-295206-vetdsk48 219 12 reduction reduction NN cord-295206-vetdsk48 219 13 in in IN cord-295206-vetdsk48 219 14 the the DT cord-295206-vetdsk48 219 15 incidence incidence NN cord-295206-vetdsk48 219 16 of of IN cord-295206-vetdsk48 219 17 acute acute JJ cord-295206-vetdsk48 219 18 exacerbations exacerbation NNS cord-295206-vetdsk48 219 19 , , , cord-295206-vetdsk48 219 20 with with IN cord-295206-vetdsk48 219 21 no no DT cord-295206-vetdsk48 219 22 impact impact NN cord-295206-vetdsk48 219 23 on on IN cord-295206-vetdsk48 219 24 the the DT cord-295206-vetdsk48 219 25 rate rate NN cord-295206-vetdsk48 219 26 of of IN cord-295206-vetdsk48 219 27 functional functional JJ cord-295206-vetdsk48 219 28 decline decline NN cord-295206-vetdsk48 219 29 . . . cord-295206-vetdsk48 220 1 The the DT cord-295206-vetdsk48 220 2 United United NNP cord-295206-vetdsk48 220 3 States States NNP cord-295206-vetdsk48 220 4 National National NNP cord-295206-vetdsk48 220 5 Heart Heart NNP cord-295206-vetdsk48 220 6 , , , cord-295206-vetdsk48 220 7 Lung Lung NNP cord-295206-vetdsk48 220 8 , , , cord-295206-vetdsk48 220 9 and and CC cord-295206-vetdsk48 220 10 Blood Blood NNP cord-295206-vetdsk48 220 11 Institute Institute NNP cord-295206-vetdsk48 220 12 and and CC cord-295206-vetdsk48 220 13 the the DT cord-295206-vetdsk48 220 14 World World NNP cord-295206-vetdsk48 220 15 Health Health NNP cord-295206-vetdsk48 220 16 Organization Organization NNP cord-295206-vetdsk48 220 17 recommend recommend VB cord-295206-vetdsk48 220 18 long long JJ cord-295206-vetdsk48 220 19 - - HYPH cord-295206-vetdsk48 220 20 term term NN cord-295206-vetdsk48 220 21 maintenance maintenance NN cord-295206-vetdsk48 220 22 therapy therapy NN cord-295206-vetdsk48 220 23 with with IN cord-295206-vetdsk48 220 24 inhaled inhale VBN cord-295206-vetdsk48 220 25 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 220 26 in in IN cord-295206-vetdsk48 220 27 symptomatic symptomatic JJ cord-295206-vetdsk48 220 28 patients patient NNS cord-295206-vetdsk48 220 29 who who WP cord-295206-vetdsk48 220 30 exhibit exhibit VBP cord-295206-vetdsk48 220 31 a a DT cord-295206-vetdsk48 220 32 documented document VBN cord-295206-vetdsk48 220 33 spirometric spirometric JJ cord-295206-vetdsk48 220 34 response response NN cord-295206-vetdsk48 220 35 to to IN cord-295206-vetdsk48 220 36 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 220 37 or or CC cord-295206-vetdsk48 220 38 who who WP cord-295206-vetdsk48 220 39 have have VBP cord-295206-vetdsk48 220 40 an an DT cord-295206-vetdsk48 220 41 FEV-1 FEV-1 NNP cord-295206-vetdsk48 220 42 of of IN cord-295206-vetdsk48 220 43 < < $ cord-295206-vetdsk48 220 44 50 50 CD cord-295206-vetdsk48 220 45 % % NN cord-295206-vetdsk48 220 46 of of IN cord-295206-vetdsk48 220 47 predicted predict VBN cord-295206-vetdsk48 220 48 and and CC cord-295206-vetdsk48 220 49 suffer suffer VB cord-295206-vetdsk48 220 50 from from IN cord-295206-vetdsk48 220 51 repeated repeat VBN cord-295206-vetdsk48 220 52 exacerbations exacerbation NNS cord-295206-vetdsk48 220 53 requiring require VBG cord-295206-vetdsk48 220 54 antibiotic antibiotic JJ cord-295206-vetdsk48 220 55 or or CC cord-295206-vetdsk48 220 56 glucocorticoid glucocorticoid NN cord-295206-vetdsk48 220 57 therapy therapy NN cord-295206-vetdsk48 220 58 Pauwels Pauwels NNP cord-295206-vetdsk48 220 59 et et NNP cord-295206-vetdsk48 220 60 al al NNP cord-295206-vetdsk48 220 61 ( ( -LRB- cord-295206-vetdsk48 220 62 2001 2001 CD cord-295206-vetdsk48 220 63 ) ) -RRB- cord-295206-vetdsk48 220 64 . . . cord-295206-vetdsk48 221 1 Systemic systemic JJ cord-295206-vetdsk48 221 2 glucocorticoids glucocorticoid NNS cord-295206-vetdsk48 221 3 should should MD cord-295206-vetdsk48 221 4 be be VB cord-295206-vetdsk48 221 5 used use VBN cord-295206-vetdsk48 221 6 in in IN cord-295206-vetdsk48 221 7 the the DT cord-295206-vetdsk48 221 8 management management NN cord-295206-vetdsk48 221 9 of of IN cord-295206-vetdsk48 221 10 acute acute JJ cord-295206-vetdsk48 221 11 exacerbation exacerbation NN cord-295206-vetdsk48 221 12 , , , cord-295206-vetdsk48 221 13 but but CC cord-295206-vetdsk48 221 14 chronic chronic JJ cord-295206-vetdsk48 221 15 treatment treatment NN cord-295206-vetdsk48 221 16 should should MD cord-295206-vetdsk48 221 17 be be VB cord-295206-vetdsk48 221 18 avoided avoid VBN cord-295206-vetdsk48 221 19 due due IN cord-295206-vetdsk48 221 20 to to IN cord-295206-vetdsk48 221 21 the the DT cord-295206-vetdsk48 221 22 potential potential NN cord-295206-vetdsk48 221 23 for for IN cord-295206-vetdsk48 221 24 severe severe JJ cord-295206-vetdsk48 221 25 adverse adverse JJ cord-295206-vetdsk48 221 26 effects effect NNS cord-295206-vetdsk48 221 27 . . . cord-295206-vetdsk48 222 1 Because because IN cord-295206-vetdsk48 222 2 influenza influenza NN cord-295206-vetdsk48 222 3 vaccines vaccine NNS cord-295206-vetdsk48 222 4 significantly significantly RB cord-295206-vetdsk48 222 5 decrease decrease VBP cord-295206-vetdsk48 222 6 morbidity morbidity NN cord-295206-vetdsk48 222 7 and and CC cord-295206-vetdsk48 222 8 mortality mortality NN cord-295206-vetdsk48 222 9 in in IN cord-295206-vetdsk48 222 10 persons person NNS cord-295206-vetdsk48 222 11 with with IN cord-295206-vetdsk48 222 12 chronic chronic JJ cord-295206-vetdsk48 222 13 bronchitis bronchitis NN cord-295206-vetdsk48 222 14 , , , cord-295206-vetdsk48 222 15 annual annual JJ cord-295206-vetdsk48 222 16 influenza influenza NN cord-295206-vetdsk48 222 17 vaccination vaccination NN cord-295206-vetdsk48 222 18 is be VBZ cord-295206-vetdsk48 222 19 recommended recommend VBN cord-295206-vetdsk48 222 20 Pauwels Pauwels NNP cord-295206-vetdsk48 222 21 et et NNP cord-295206-vetdsk48 222 22 al al NNP cord-295206-vetdsk48 222 23 ( ( -LRB- cord-295206-vetdsk48 222 24 2001 2001 CD cord-295206-vetdsk48 222 25 ) ) -RRB- cord-295206-vetdsk48 222 26 . . . cord-295206-vetdsk48 223 1 The the DT cord-295206-vetdsk48 223 2 pneumococcal pneumococcal JJ cord-295206-vetdsk48 223 3 vaccine vaccine NN cord-295206-vetdsk48 223 4 has have VBZ cord-295206-vetdsk48 223 5 been be VBN cord-295206-vetdsk48 223 6 used use VBN cord-295206-vetdsk48 223 7 in in IN cord-295206-vetdsk48 223 8 patients patient NNS cord-295206-vetdsk48 223 9 with with IN cord-295206-vetdsk48 223 10 chronic chronic JJ cord-295206-vetdsk48 223 11 bronchitis bronchitis NN cord-295206-vetdsk48 223 12 , , , cord-295206-vetdsk48 223 13 but but CC cord-295206-vetdsk48 223 14 there there EX cord-295206-vetdsk48 223 15 are be VBP cord-295206-vetdsk48 223 16 insufficient insufficient JJ cord-295206-vetdsk48 223 17 data datum NNS cord-295206-vetdsk48 223 18 to to TO cord-295206-vetdsk48 223 19 support support VB cord-295206-vetdsk48 223 20 its -PRON- PRP$ cord-295206-vetdsk48 223 21 general general JJ cord-295206-vetdsk48 223 22 use use NN cord-295206-vetdsk48 223 23 for for IN cord-295206-vetdsk48 223 24 this this DT cord-295206-vetdsk48 223 25 purpose purpose NN cord-295206-vetdsk48 223 26 . . . cord-295206-vetdsk48 224 1 Non non JJ cord-295206-vetdsk48 224 2 - - JJ cord-295206-vetdsk48 224 3 steroidal steroidal JJ cord-295206-vetdsk48 224 4 antiinflammatory antiinflammatory JJ cord-295206-vetdsk48 224 5 drugs drug NNS cord-295206-vetdsk48 225 1 Non non JJ cord-295206-vetdsk48 225 2 - - JJ cord-295206-vetdsk48 225 3 steroidal steroidal JJ cord-295206-vetdsk48 225 4 antiinflammatory antiinflammatory JJ cord-295206-vetdsk48 225 5 agents agent NNS cord-295206-vetdsk48 225 6 such such JJ cord-295206-vetdsk48 225 7 as as IN cord-295206-vetdsk48 225 8 ibuprofen ibuprofen NN cord-295206-vetdsk48 225 9 and and CC cord-295206-vetdsk48 225 10 antipyretic antipyretic JJ cord-295206-vetdsk48 225 11 pain pain NN cord-295206-vetdsk48 225 12 relievers reliever NNS cord-295206-vetdsk48 225 13 , , , cord-295206-vetdsk48 225 14 such such JJ cord-295206-vetdsk48 225 15 as as IN cord-295206-vetdsk48 225 16 acetaminophen acetaminophen NN cord-295206-vetdsk48 225 17 , , , cord-295206-vetdsk48 225 18 may may MD cord-295206-vetdsk48 225 19 be be VB cord-295206-vetdsk48 225 20 used use VBN cord-295206-vetdsk48 225 21 to to TO cord-295206-vetdsk48 225 22 lessen lessen VB cord-295206-vetdsk48 225 23 the the DT cord-295206-vetdsk48 225 24 symptoms symptom NNS cord-295206-vetdsk48 225 25 of of IN cord-295206-vetdsk48 225 26 the the DT cord-295206-vetdsk48 225 27 acute acute JJ cord-295206-vetdsk48 225 28 phase phase NN cord-295206-vetdsk48 225 29 of of IN cord-295206-vetdsk48 225 30 acute acute JJ cord-295206-vetdsk48 225 31 bronchitis bronchitis NN cord-295206-vetdsk48 225 32 ( ( -LRB- cord-295206-vetdsk48 225 33 e.g. e.g. RB cord-295206-vetdsk48 225 34 , , , cord-295206-vetdsk48 225 35 fever fever NN cord-295206-vetdsk48 225 36 , , , cord-295206-vetdsk48 225 37 muscle muscle NN cord-295206-vetdsk48 225 38 aches ache NNS cord-295206-vetdsk48 225 39 ) ) -RRB- cord-295206-vetdsk48 226 1 Gonzales Gonzales NNP cord-295206-vetdsk48 226 2 and and CC cord-295206-vetdsk48 226 3 Sande Sande NNP cord-295206-vetdsk48 226 4 ( ( -LRB- cord-295206-vetdsk48 226 5 2000 2000 CD cord-295206-vetdsk48 226 6 ) ) -RRB- cord-295206-vetdsk48 226 7 . . . cord-295206-vetdsk48 227 1 In in IN cord-295206-vetdsk48 227 2 cases case NNS cord-295206-vetdsk48 227 3 of of IN cord-295206-vetdsk48 227 4 acute acute JJ cord-295206-vetdsk48 227 5 bronchitis bronchitis NN cord-295206-vetdsk48 227 6 caused cause VBN cord-295206-vetdsk48 227 7 by by IN cord-295206-vetdsk48 227 8 influenza influenza NN cord-295206-vetdsk48 227 9 A A NNP cord-295206-vetdsk48 227 10 , , , cord-295206-vetdsk48 227 11 amantadine amantadine NN cord-295206-vetdsk48 227 12 or or CC cord-295206-vetdsk48 227 13 rimantadine rimantadine NNP cord-295206-vetdsk48 227 14 may may MD cord-295206-vetdsk48 227 15 be be VB cord-295206-vetdsk48 227 16 effective effective JJ cord-295206-vetdsk48 227 17 if if IN cord-295206-vetdsk48 227 18 given give VBN cord-295206-vetdsk48 227 19 within within IN cord-295206-vetdsk48 227 20 48 48 CD cord-295206-vetdsk48 227 21 hours hour NNS cord-295206-vetdsk48 227 22 of of IN cord-295206-vetdsk48 227 23 the the DT cord-295206-vetdsk48 227 24 onset onset NN cord-295206-vetdsk48 227 25 of of IN cord-295206-vetdsk48 227 26 symptoms symptom NNS cord-295206-vetdsk48 227 27 Gonzales Gonzales NNP cord-295206-vetdsk48 227 28 and and CC cord-295206-vetdsk48 227 29 Sande Sande NNP cord-295206-vetdsk48 227 30 ( ( -LRB- cord-295206-vetdsk48 227 31 2000 2000 CD cord-295206-vetdsk48 227 32 ) ) -RRB- cord-295206-vetdsk48 227 33 . . . cord-295206-vetdsk48 228 1 These these DT cord-295206-vetdsk48 228 2 drugs drug NNS cord-295206-vetdsk48 228 3 block block VBP cord-295206-vetdsk48 228 4 the the DT cord-295206-vetdsk48 228 5 proton proton NN cord-295206-vetdsk48 228 6 channel channel NN cord-295206-vetdsk48 228 7 required require VBN cord-295206-vetdsk48 228 8 for for IN cord-295206-vetdsk48 228 9 the the DT cord-295206-vetdsk48 228 10 dissolution dissolution NN cord-295206-vetdsk48 228 11 of of IN cord-295206-vetdsk48 228 12 the the DT cord-295206-vetdsk48 228 13 viral viral JJ cord-295206-vetdsk48 228 14 ribonucleoprotein ribonucleoprotein NN cord-295206-vetdsk48 228 15 complex complex NN cord-295206-vetdsk48 228 16 early early RB cord-295206-vetdsk48 228 17 in in IN cord-295206-vetdsk48 228 18 the the DT cord-295206-vetdsk48 228 19 process process NN cord-295206-vetdsk48 228 20 of of IN cord-295206-vetdsk48 228 21 replication replication NN cord-295206-vetdsk48 228 22 . . . cord-295206-vetdsk48 229 1 Zanamivir Zanamivir NNP cord-295206-vetdsk48 229 2 and and CC cord-295206-vetdsk48 229 3 oseltamivir oseltamivir NNS cord-295206-vetdsk48 229 4 are be VBP cord-295206-vetdsk48 229 5 effective effective JJ cord-295206-vetdsk48 229 6 against against IN cord-295206-vetdsk48 229 7 influenza influenza NN cord-295206-vetdsk48 229 8 A a NN cord-295206-vetdsk48 229 9 and and CC cord-295206-vetdsk48 229 10 B b NN cord-295206-vetdsk48 230 1 and and CC cord-295206-vetdsk48 230 2 , , , cord-295206-vetdsk48 230 3 like like IN cord-295206-vetdsk48 230 4 amantadine amantadine NNP cord-295206-vetdsk48 230 5 and and CC cord-295206-vetdsk48 230 6 rimantadine rimantadine NNP cord-295206-vetdsk48 230 7 , , , cord-295206-vetdsk48 230 8 must must MD cord-295206-vetdsk48 230 9 be be VB cord-295206-vetdsk48 230 10 taken take VBN cord-295206-vetdsk48 230 11 within within IN cord-295206-vetdsk48 230 12 the the DT cord-295206-vetdsk48 230 13 first first JJ cord-295206-vetdsk48 230 14 48 48 CD cord-295206-vetdsk48 230 15 hours hour NNS cord-295206-vetdsk48 230 16 of of IN cord-295206-vetdsk48 230 17 illness illness NN cord-295206-vetdsk48 230 18 . . . cord-295206-vetdsk48 231 1 These these DT cord-295206-vetdsk48 231 2 drugs drug NNS cord-295206-vetdsk48 231 3 inhibit inhibit VBP cord-295206-vetdsk48 231 4 neuraminidase neuraminidase NN cord-295206-vetdsk48 231 5 , , , cord-295206-vetdsk48 231 6 a a DT cord-295206-vetdsk48 231 7 viral viral JJ cord-295206-vetdsk48 231 8 surface surface NN cord-295206-vetdsk48 231 9 glycoprotein glycoprotein NN cord-295206-vetdsk48 231 10 involved involve VBN cord-295206-vetdsk48 231 11 in in IN cord-295206-vetdsk48 231 12 the the DT cord-295206-vetdsk48 231 13 release release NN cord-295206-vetdsk48 231 14 of of IN cord-295206-vetdsk48 231 15 progeny progeny JJ cord-295206-vetdsk48 231 16 virus virus NN cord-295206-vetdsk48 231 17 and and CC cord-295206-vetdsk48 231 18 in in IN cord-295206-vetdsk48 231 19 the the DT cord-295206-vetdsk48 231 20 spread spread NN cord-295206-vetdsk48 231 21 of of IN cord-295206-vetdsk48 231 22 infection infection NN cord-295206-vetdsk48 231 23 from from IN cord-295206-vetdsk48 231 24 cell cell NN cord-295206-vetdsk48 231 25 to to IN cord-295206-vetdsk48 231 26 cell cell NN cord-295206-vetdsk48 231 27 . . . cord-295206-vetdsk48 232 1 A a DT cord-295206-vetdsk48 232 2 large large JJ cord-295206-vetdsk48 232 3 number number NN cord-295206-vetdsk48 232 4 of of IN cord-295206-vetdsk48 232 5 experimental experimental JJ cord-295206-vetdsk48 232 6 therapies therapy NNS cord-295206-vetdsk48 232 7 are be VBP cord-295206-vetdsk48 232 8 under under IN cord-295206-vetdsk48 232 9 development development NN cord-295206-vetdsk48 232 10 for for IN cord-295206-vetdsk48 232 11 the the DT cord-295206-vetdsk48 232 12 treatment treatment NN cord-295206-vetdsk48 232 13 of of IN cord-295206-vetdsk48 232 14 chronic chronic JJ cord-295206-vetdsk48 232 15 obstructive obstructive JJ cord-295206-vetdsk48 232 16 pulmonary pulmonary JJ cord-295206-vetdsk48 232 17 disease disease NN cord-295206-vetdsk48 232 18 . . . cord-295206-vetdsk48 233 1 With with IN cord-295206-vetdsk48 233 2 the the DT cord-295206-vetdsk48 233 3 exception exception NN cord-295206-vetdsk48 233 4 of of IN cord-295206-vetdsk48 233 5 novel novel NN cord-295206-vetdsk48 233 6 antiinfective antiinfective JJ cord-295206-vetdsk48 233 7 agents agent NNS cord-295206-vetdsk48 233 8 and and CC cord-295206-vetdsk48 233 9 the the DT cord-295206-vetdsk48 233 10 anticholinergic anticholinergic JJ cord-295206-vetdsk48 233 11 bronchodilator bronchodilator NN cord-295206-vetdsk48 233 12 tiotropium tiotropium NN cord-295206-vetdsk48 233 13 , , , cord-295206-vetdsk48 233 14 there there EX cord-295206-vetdsk48 233 15 are be VBP cord-295206-vetdsk48 233 16 few few JJ cord-295206-vetdsk48 233 17 experimental experimental JJ cord-295206-vetdsk48 233 18 therapies therapy NNS cord-295206-vetdsk48 233 19 under under IN cord-295206-vetdsk48 233 20 development development NN cord-295206-vetdsk48 233 21 for for IN cord-295206-vetdsk48 233 22 the the DT cord-295206-vetdsk48 233 23 treatment treatment NN cord-295206-vetdsk48 233 24 of of IN cord-295206-vetdsk48 233 25 acute acute JJ cord-295206-vetdsk48 233 26 infectious infectious JJ cord-295206-vetdsk48 233 27 bronchitis bronchitis NN cord-295206-vetdsk48 233 28 . . . cord-295206-vetdsk48 234 1 Mucolytic mucolytic JJ cord-295206-vetdsk48 234 2 agents agent NNS cord-295206-vetdsk48 235 1 Because because IN cord-295206-vetdsk48 235 2 mucus mucus NN cord-295206-vetdsk48 235 3 hypersecretion hypersecretion NN cord-295206-vetdsk48 235 4 and and CC cord-295206-vetdsk48 235 5 impaired impair VBN cord-295206-vetdsk48 235 6 mucociliary mucociliary JJ cord-295206-vetdsk48 235 7 clearance clearance NN cord-295206-vetdsk48 235 8 are be VBP cord-295206-vetdsk48 235 9 characteristic characteristic JJ cord-295206-vetdsk48 235 10 of of IN cord-295206-vetdsk48 235 11 chronic chronic JJ cord-295206-vetdsk48 235 12 bronchitis bronchitis NN cord-295206-vetdsk48 235 13 , , , cord-295206-vetdsk48 235 14 attempts attempt NNS cord-295206-vetdsk48 235 15 are be VBP cord-295206-vetdsk48 235 16 being be VBG cord-295206-vetdsk48 235 17 made make VBN cord-295206-vetdsk48 235 18 to to TO cord-295206-vetdsk48 235 19 speed speed VB cord-295206-vetdsk48 235 20 the the DT cord-295206-vetdsk48 235 21 transport transport NN cord-295206-vetdsk48 235 22 of of IN cord-295206-vetdsk48 235 23 mucus mucus NN cord-295206-vetdsk48 235 24 up up IN cord-295206-vetdsk48 235 25 the the DT cord-295206-vetdsk48 235 26 bronchiotracheal bronchiotracheal JJ cord-295206-vetdsk48 235 27 tree tree NN cord-295206-vetdsk48 235 28 Wegner Wegner NNP cord-295206-vetdsk48 235 29 ( ( -LRB- cord-295206-vetdsk48 235 30 2001 2001 CD cord-295206-vetdsk48 235 31 ) ) -RRB- cord-295206-vetdsk48 235 32 . . . cord-295206-vetdsk48 236 1 Oral oral JJ cord-295206-vetdsk48 236 2 expectorants expectorant NNS cord-295206-vetdsk48 236 3 such such JJ cord-295206-vetdsk48 236 4 as as IN cord-295206-vetdsk48 236 5 guaifenesin guaifenesin NN cord-295206-vetdsk48 236 6 are be VBP cord-295206-vetdsk48 236 7 of of IN cord-295206-vetdsk48 236 8 little little JJ cord-295206-vetdsk48 236 9 benefit benefit NN cord-295206-vetdsk48 236 10 in in IN cord-295206-vetdsk48 236 11 chronic chronic JJ cord-295206-vetdsk48 236 12 obstructive obstructive JJ cord-295206-vetdsk48 236 13 pulmonary pulmonary JJ cord-295206-vetdsk48 236 14 disease disease NN cord-295206-vetdsk48 236 15 . . . cord-295206-vetdsk48 237 1 N n NN cord-295206-vetdsk48 237 2 - - HYPH cord-295206-vetdsk48 237 3 acetylcysteine acetylcysteine NN cord-295206-vetdsk48 237 4 is be VBZ cord-295206-vetdsk48 237 5 an an DT cord-295206-vetdsk48 237 6 orally orally RB cord-295206-vetdsk48 237 7 administered administer VBN cord-295206-vetdsk48 237 8 glutathione glutathione NN cord-295206-vetdsk48 237 9 precursor precursor NN cord-295206-vetdsk48 237 10 that that WDT cord-295206-vetdsk48 237 11 reduces reduce VBZ cord-295206-vetdsk48 237 12 the the DT cord-295206-vetdsk48 237 13 sulfhydryl sulfhydryl NN cord-295206-vetdsk48 237 14 bonds bond NNS cord-295206-vetdsk48 237 15 of of IN cord-295206-vetdsk48 237 16 mucus mucus NN cord-295206-vetdsk48 237 17 proteins protein NNS cord-295206-vetdsk48 237 18 . . . cord-295206-vetdsk48 238 1 It -PRON- PRP cord-295206-vetdsk48 238 2 has have VBZ cord-295206-vetdsk48 238 3 been be VBN cord-295206-vetdsk48 238 4 shown show VBN cord-295206-vetdsk48 238 5 to to IN cord-295206-vetdsk48 238 6 thin thin JJ cord-295206-vetdsk48 238 7 the the DT cord-295206-vetdsk48 238 8 sputum sputum NN cord-295206-vetdsk48 238 9 without without IN cord-295206-vetdsk48 238 10 producing produce VBG cord-295206-vetdsk48 238 11 significant significant JJ cord-295206-vetdsk48 238 12 improvement improvement NN cord-295206-vetdsk48 238 13 in in IN cord-295206-vetdsk48 238 14 pulmonary pulmonary JJ cord-295206-vetdsk48 238 15 function function NN cord-295206-vetdsk48 238 16 . . . cord-295206-vetdsk48 239 1 Preliminary preliminary JJ cord-295206-vetdsk48 239 2 studies study NNS cord-295206-vetdsk48 239 3 suggest suggest VBP cord-295206-vetdsk48 239 4 that that IN cord-295206-vetdsk48 239 5 n n NN cord-295206-vetdsk48 239 6 - - HYPH cord-295206-vetdsk48 239 7 acetylcysteine acetylcysteine NN cord-295206-vetdsk48 239 8 may may MD cord-295206-vetdsk48 239 9 reduce reduce VB cord-295206-vetdsk48 239 10 the the DT cord-295206-vetdsk48 239 11 frequency frequency NN cord-295206-vetdsk48 239 12 of of IN cord-295206-vetdsk48 239 13 acute acute JJ cord-295206-vetdsk48 239 14 exacerbations exacerbation NNS cord-295206-vetdsk48 239 15 , , , cord-295206-vetdsk48 239 16 an an DT cord-295206-vetdsk48 239 17 action action NN cord-295206-vetdsk48 239 18 that that WDT cord-295206-vetdsk48 239 19 may may MD cord-295206-vetdsk48 239 20 be be VB cord-295206-vetdsk48 239 21 related relate VBN cord-295206-vetdsk48 239 22 to to IN cord-295206-vetdsk48 239 23 its -PRON- PRP$ cord-295206-vetdsk48 239 24 efficacy efficacy NN cord-295206-vetdsk48 239 25 as as IN cord-295206-vetdsk48 239 26 an an DT cord-295206-vetdsk48 239 27 antioxidant antioxidant NN cord-295206-vetdsk48 239 28 . . . cord-295206-vetdsk48 240 1 Heliox Heliox NNP cord-295206-vetdsk48 240 2 Heliox Heliox NNP cord-295206-vetdsk48 240 3 is be VBZ cord-295206-vetdsk48 240 4 a a DT cord-295206-vetdsk48 240 5 mixture mixture NN cord-295206-vetdsk48 240 6 of of IN cord-295206-vetdsk48 240 7 helium helium NN cord-295206-vetdsk48 240 8 and and CC cord-295206-vetdsk48 240 9 oxygen oxygen NN cord-295206-vetdsk48 240 10 that that WDT cord-295206-vetdsk48 240 11 changes change VBZ cord-295206-vetdsk48 240 12 pulmonary pulmonary JJ cord-295206-vetdsk48 240 13 airflow airflow NN cord-295206-vetdsk48 240 14 from from IN cord-295206-vetdsk48 240 15 turbulent turbulent JJ cord-295206-vetdsk48 240 16 to to IN cord-295206-vetdsk48 240 17 laminar laminar JJ cord-295206-vetdsk48 240 18 . . . cord-295206-vetdsk48 241 1 It -PRON- PRP cord-295206-vetdsk48 241 2 has have VBZ cord-295206-vetdsk48 241 3 been be VBN cord-295206-vetdsk48 241 4 shown show VBN cord-295206-vetdsk48 241 5 to to TO cord-295206-vetdsk48 241 6 decrease decrease VB cord-295206-vetdsk48 241 7 the the DT cord-295206-vetdsk48 241 8 work work NN cord-295206-vetdsk48 241 9 of of IN cord-295206-vetdsk48 241 10 breathing breathing NN cord-295206-vetdsk48 241 11 in in IN cord-295206-vetdsk48 241 12 severe severe JJ cord-295206-vetdsk48 241 13 , , , cord-295206-vetdsk48 241 14 stable stable JJ cord-295206-vetdsk48 241 15 , , , cord-295206-vetdsk48 241 16 chronic chronic JJ cord-295206-vetdsk48 241 17 obstructive obstructive JJ cord-295206-vetdsk48 241 18 pulmonary pulmonary JJ cord-295206-vetdsk48 241 19 disease disease NN cord-295206-vetdsk48 241 20 and and CC cord-295206-vetdsk48 241 21 may may MD cord-295206-vetdsk48 241 22 potentially potentially RB cord-295206-vetdsk48 241 23 be be VB cord-295206-vetdsk48 241 24 useful useful JJ cord-295206-vetdsk48 241 25 in in IN cord-295206-vetdsk48 241 26 the the DT cord-295206-vetdsk48 241 27 treatment treatment NN cord-295206-vetdsk48 241 28 of of IN cord-295206-vetdsk48 241 29 acute acute JJ cord-295206-vetdsk48 241 30 exacerbations exacerbation NNS cord-295206-vetdsk48 241 31 of of IN cord-295206-vetdsk48 241 32 chronic chronic JJ cord-295206-vetdsk48 241 33 bronchitis bronchitis NN cord-295206-vetdsk48 241 34 Chitkara Chitkara NNP cord-295206-vetdsk48 241 35 and and CC cord-295206-vetdsk48 241 36 Sarinas Sarinas NNP cord-295206-vetdsk48 241 37 ( ( -LRB- cord-295206-vetdsk48 241 38 2002 2002 CD cord-295206-vetdsk48 241 39 ) ) -RRB- cord-295206-vetdsk48 241 40 , , , cord-295206-vetdsk48 241 41 Rodrigo Rodrigo NNP cord-295206-vetdsk48 241 42 et et NNP cord-295206-vetdsk48 241 43 al al NNP cord-295206-vetdsk48 241 44 ( ( -LRB- cord-295206-vetdsk48 241 45 2002 2002 CD cord-295206-vetdsk48 241 46 ) ) -RRB- cord-295206-vetdsk48 241 47 . . . cord-295206-vetdsk48 242 1 Phosphodiesterase-4 Phosphodiesterase-4 NNP cord-295206-vetdsk48 243 1 ( ( -LRB- cord-295206-vetdsk48 243 2 PDE-4 PDE-4 NNP cord-295206-vetdsk48 243 3 ) ) -RRB- cord-295206-vetdsk48 243 4 is be VBZ cord-295206-vetdsk48 243 5 a a DT cord-295206-vetdsk48 243 6 cyclic cyclic JJ cord-295206-vetdsk48 243 7 AMP amp NN cord-295206-vetdsk48 243 8 - - HYPH cord-295206-vetdsk48 243 9 specific specific JJ cord-295206-vetdsk48 243 10 phosphodiesterase phosphodiesterase NN cord-295206-vetdsk48 243 11 that that WDT cord-295206-vetdsk48 243 12 predominates predominate VBZ cord-295206-vetdsk48 243 13 in in IN cord-295206-vetdsk48 243 14 pro pro JJ cord-295206-vetdsk48 243 15 - - JJ cord-295206-vetdsk48 243 16 inflammatory inflammatory JJ cord-295206-vetdsk48 243 17 and and CC cord-295206-vetdsk48 243 18 immune immune JJ cord-295206-vetdsk48 243 19 cells cell NNS cord-295206-vetdsk48 243 20 . . . cord-295206-vetdsk48 244 1 Cilomilast Cilomilast NNP cord-295206-vetdsk48 244 2 is be VBZ cord-295206-vetdsk48 244 3 a a DT cord-295206-vetdsk48 244 4 new new JJ cord-295206-vetdsk48 244 5 , , , cord-295206-vetdsk48 244 6 orally orally RB cord-295206-vetdsk48 244 7 active active JJ cord-295206-vetdsk48 244 8 , , , cord-295206-vetdsk48 244 9 selective selective JJ cord-295206-vetdsk48 244 10 inhibitor inhibitor NN cord-295206-vetdsk48 244 11 of of IN cord-295206-vetdsk48 244 12 PDE-4 PDE-4 NNP cord-295206-vetdsk48 244 13 . . . cord-295206-vetdsk48 245 1 Initial initial JJ cord-295206-vetdsk48 245 2 studies study NNS cord-295206-vetdsk48 245 3 of of IN cord-295206-vetdsk48 245 4 cilomilast cilomilast NNP cord-295206-vetdsk48 245 5 revealed reveal VBD cord-295206-vetdsk48 245 6 significant significant JJ cord-295206-vetdsk48 245 7 functional functional JJ cord-295206-vetdsk48 245 8 improvement improvement NN cord-295206-vetdsk48 245 9 of of IN cord-295206-vetdsk48 245 10 chronic chronic JJ cord-295206-vetdsk48 245 11 obstructive obstructive JJ cord-295206-vetdsk48 245 12 pulmonary pulmonary JJ cord-295206-vetdsk48 245 13 disease disease NN cord-295206-vetdsk48 245 14 ( ( -LRB- cord-295206-vetdsk48 245 15 COPD COPD NNP cord-295206-vetdsk48 245 16 ) ) -RRB- cord-295206-vetdsk48 245 17 with with IN cord-295206-vetdsk48 245 18 minimal minimal JJ cord-295206-vetdsk48 245 19 side side NN cord-295206-vetdsk48 245 20 effects effect NNS cord-295206-vetdsk48 245 21 Giembycz Giembycz NNP cord-295206-vetdsk48 245 22 ( ( -LRB- cord-295206-vetdsk48 245 23 2001 2001 CD cord-295206-vetdsk48 245 24 ) ) -RRB- cord-295206-vetdsk48 245 25 . . . cord-295206-vetdsk48 246 1 There there EX cord-295206-vetdsk48 246 2 is be VBZ cord-295206-vetdsk48 246 3 a a DT cord-295206-vetdsk48 246 4 significant significant JJ cord-295206-vetdsk48 246 5 decrease decrease NN cord-295206-vetdsk48 246 6 in in IN cord-295206-vetdsk48 246 7 the the DT cord-295206-vetdsk48 246 8 number number NN cord-295206-vetdsk48 246 9 of of IN cord-295206-vetdsk48 246 10 CD8 CD8 NNP cord-295206-vetdsk48 246 11 + + SYM cord-295206-vetdsk48 246 12 and and CC cord-295206-vetdsk48 246 13 CD68 CD68 NNP cord-295206-vetdsk48 246 14 + + CC cord-295206-vetdsk48 246 15 inflammatory inflammatory JJ cord-295206-vetdsk48 246 16 cells cell NNS cord-295206-vetdsk48 246 17 characteristic characteristic JJ cord-295206-vetdsk48 246 18 of of IN cord-295206-vetdsk48 246 19 COPD COPD NNP cord-295206-vetdsk48 246 20 without without IN cord-295206-vetdsk48 246 21 alteration alteration NN cord-295206-vetdsk48 246 22 of of IN cord-295206-vetdsk48 246 23 sputum sputum NN cord-295206-vetdsk48 246 24 values value NNS cord-295206-vetdsk48 246 25 or or CC cord-295206-vetdsk48 246 26 FEV-1 FEV-1 NNP cord-295206-vetdsk48 246 27 Gamble Gamble NNP cord-295206-vetdsk48 246 28 et et NNP cord-295206-vetdsk48 246 29 al al NNP cord-295206-vetdsk48 246 30 ( ( -LRB- cord-295206-vetdsk48 246 31 2003 2003 CD cord-295206-vetdsk48 246 32 ) ) -RRB- cord-295206-vetdsk48 246 33 . . . cord-295206-vetdsk48 247 1 Tiotropium Tiotropium NNP cord-295206-vetdsk48 247 2 is be VBZ cord-295206-vetdsk48 247 3 an an DT cord-295206-vetdsk48 247 4 inhaled inhale VBN cord-295206-vetdsk48 247 5 anticholinergic anticholinergic NN cord-295206-vetdsk48 247 6 that that WDT cord-295206-vetdsk48 247 7 is be VBZ cord-295206-vetdsk48 247 8 available available JJ cord-295206-vetdsk48 247 9 in in IN cord-295206-vetdsk48 247 10 Europe Europe NNP cord-295206-vetdsk48 247 11 and and CC cord-295206-vetdsk48 247 12 is be VBZ cord-295206-vetdsk48 247 13 pending pende VBG cord-295206-vetdsk48 247 14 FDA FDA NNP cord-295206-vetdsk48 247 15 approval approval NN cord-295206-vetdsk48 247 16 in in IN cord-295206-vetdsk48 247 17 the the DT cord-295206-vetdsk48 247 18 United United NNP cord-295206-vetdsk48 247 19 States States NNP cord-295206-vetdsk48 247 20 Barnes Barnes NNP cord-295206-vetdsk48 247 21 ( ( -LRB- cord-295206-vetdsk48 247 22 2003 2003 CD cord-295206-vetdsk48 247 23 ) ) -RRB- cord-295206-vetdsk48 247 24 . . . cord-295206-vetdsk48 248 1 It -PRON- PRP cord-295206-vetdsk48 248 2 exhibits exhibit VBZ cord-295206-vetdsk48 248 3 very very RB cord-295206-vetdsk48 248 4 slow slow JJ cord-295206-vetdsk48 248 5 dissociation dissociation NN cord-295206-vetdsk48 248 6 from from IN cord-295206-vetdsk48 248 7 M-1 M-1 NNP cord-295206-vetdsk48 248 8 muscarinic muscarinic JJ cord-295206-vetdsk48 248 9 receptors receptor NNS cord-295206-vetdsk48 248 10 and and CC cord-295206-vetdsk48 248 11 M-3 M-3 NNP cord-295206-vetdsk48 248 12 muscarinic muscarinic JJ cord-295206-vetdsk48 248 13 receptors receptor NNS cord-295206-vetdsk48 248 14 , , , cord-295206-vetdsk48 248 15 allowing allow VBG cord-295206-vetdsk48 248 16 it -PRON- PRP cord-295206-vetdsk48 248 17 to to TO cord-295206-vetdsk48 248 18 provide provide VB cord-295206-vetdsk48 248 19 once once RB cord-295206-vetdsk48 248 20 - - HYPH cord-295206-vetdsk48 248 21 daily daily NN cord-295206-vetdsk48 248 22 dosing dosing NN cord-295206-vetdsk48 248 23 and and CC cord-295206-vetdsk48 248 24 a a DT cord-295206-vetdsk48 248 25 greater great JJR cord-295206-vetdsk48 248 26 degree degree NN cord-295206-vetdsk48 248 27 of of IN cord-295206-vetdsk48 248 28 stability stability NN cord-295206-vetdsk48 248 29 in in IN cord-295206-vetdsk48 248 30 lung lung NN cord-295206-vetdsk48 248 31 function function NN cord-295206-vetdsk48 248 32 than than IN cord-295206-vetdsk48 248 33 ipratropium ipratropium NNP cord-295206-vetdsk48 248 34 . . . cord-295206-vetdsk48 249 1 Tiotropium Tiotropium NNP cord-295206-vetdsk48 249 2 may may MD cord-295206-vetdsk48 249 3 be be VB cord-295206-vetdsk48 249 4 useful useful JJ cord-295206-vetdsk48 249 5 in in IN cord-295206-vetdsk48 249 6 acute acute JJ cord-295206-vetdsk48 249 7 or or CC cord-295206-vetdsk48 249 8 chronic chronic JJ cord-295206-vetdsk48 249 9 bronchitis bronchitis NN cord-295206-vetdsk48 249 10 . . . cord-295206-vetdsk48 250 1 Leukotriene Leukotriene NNP cord-295206-vetdsk48 250 2 B-4 B-4 NNP cord-295206-vetdsk48 250 3 ( ( -LRB- cord-295206-vetdsk48 250 4 LTB-4 LTB-4 NNP cord-295206-vetdsk48 250 5 ) ) -RRB- cord-295206-vetdsk48 250 6 is be VBZ cord-295206-vetdsk48 250 7 a a DT cord-295206-vetdsk48 250 8 mediator mediator NN cord-295206-vetdsk48 250 9 of of IN cord-295206-vetdsk48 250 10 neutrophilic neutrophilic JJ cord-295206-vetdsk48 250 11 inflammation inflammation NN cord-295206-vetdsk48 250 12 that that WDT cord-295206-vetdsk48 250 13 is be VBZ cord-295206-vetdsk48 250 14 elevated elevate VBN cord-295206-vetdsk48 250 15 in in IN cord-295206-vetdsk48 250 16 the the DT cord-295206-vetdsk48 250 17 sputum sputum NN cord-295206-vetdsk48 250 18 of of IN cord-295206-vetdsk48 250 19 persons person NNS cord-295206-vetdsk48 250 20 with with IN cord-295206-vetdsk48 250 21 chronic chronic JJ cord-295206-vetdsk48 250 22 bronchitis bronchitis NN cord-295206-vetdsk48 250 23 . . . cord-295206-vetdsk48 251 1 Several several JJ cord-295206-vetdsk48 251 2 antagonists antagonist NNS cord-295206-vetdsk48 251 3 of of IN cord-295206-vetdsk48 251 4 LTB-4 ltb-4 JJ cord-295206-vetdsk48 251 5 receptors receptor NNS cord-295206-vetdsk48 251 6 are be VBP cord-295206-vetdsk48 251 7 in in IN cord-295206-vetdsk48 251 8 clinical clinical JJ cord-295206-vetdsk48 251 9 development development NN cord-295206-vetdsk48 251 10 and and CC cord-295206-vetdsk48 251 11 may may MD cord-295206-vetdsk48 251 12 be be VB cord-295206-vetdsk48 251 13 useful useful JJ cord-295206-vetdsk48 251 14 in in IN cord-295206-vetdsk48 251 15 the the DT cord-295206-vetdsk48 251 16 treatment treatment NN cord-295206-vetdsk48 251 17 of of IN cord-295206-vetdsk48 251 18 chronic chronic JJ cord-295206-vetdsk48 251 19 bronchitis bronchitis NN cord-295206-vetdsk48 251 20 Kilfeather Kilfeather NNP cord-295206-vetdsk48 251 21 ( ( -LRB- cord-295206-vetdsk48 251 22 2002 2002 CD cord-295206-vetdsk48 251 23 ) ) -RRB- cord-295206-vetdsk48 251 24 . . . cord-295206-vetdsk48 252 1 A a DT cord-295206-vetdsk48 252 2 number number NN cord-295206-vetdsk48 252 3 of of IN cord-295206-vetdsk48 252 4 agents agent NNS cord-295206-vetdsk48 252 5 that that WDT cord-295206-vetdsk48 252 6 act act VBP cord-295206-vetdsk48 252 7 through through IN cord-295206-vetdsk48 252 8 cytokine cytokine JJ cord-295206-vetdsk48 252 9 pathways pathway NNS cord-295206-vetdsk48 252 10 that that WDT cord-295206-vetdsk48 252 11 mediate mediate VBP cord-295206-vetdsk48 252 12 the the DT cord-295206-vetdsk48 252 13 symptoms symptom NNS cord-295206-vetdsk48 252 14 of of IN cord-295206-vetdsk48 252 15 chronic chronic JJ cord-295206-vetdsk48 252 16 obstructive obstructive JJ cord-295206-vetdsk48 252 17 lung lung NN cord-295206-vetdsk48 252 18 disease disease NN cord-295206-vetdsk48 252 19 ( ( -LRB- cord-295206-vetdsk48 252 20 COPD COPD NNP cord-295206-vetdsk48 252 21 ) ) -RRB- cord-295206-vetdsk48 252 22 are be VBP cord-295206-vetdsk48 252 23 under under IN cord-295206-vetdsk48 252 24 investigation investigation NN cord-295206-vetdsk48 252 25 Barnes Barnes NNP cord-295206-vetdsk48 252 26 ( ( -LRB- cord-295206-vetdsk48 252 27 2003 2003 CD cord-295206-vetdsk48 252 28 ) ) -RRB- cord-295206-vetdsk48 252 29 , , , cord-295206-vetdsk48 252 30 Reid Reid NNP cord-295206-vetdsk48 252 31 and and CC cord-295206-vetdsk48 252 32 Sallenave Sallenave NNP cord-295206-vetdsk48 252 33 ( ( -LRB- cord-295206-vetdsk48 252 34 2003 2003 CD cord-295206-vetdsk48 252 35 ) ) -RRB- cord-295206-vetdsk48 252 36 . . . cord-295206-vetdsk48 253 1 Interleukin-10 Interleukin-10 NNP cord-295206-vetdsk48 253 2 ( ( -LRB- cord-295206-vetdsk48 253 3 IL-10 IL-10 NNP cord-295206-vetdsk48 253 4 ) ) -RRB- cord-295206-vetdsk48 253 5 , , , cord-295206-vetdsk48 253 6 an an DT cord-295206-vetdsk48 253 7 anti anti JJ cord-295206-vetdsk48 253 8 - - JJ cord-295206-vetdsk48 253 9 inflammatory inflammatory JJ cord-295206-vetdsk48 253 10 cytokine cytokine NN cord-295206-vetdsk48 253 11 , , , cord-295206-vetdsk48 253 12 decreases decrease VBZ cord-295206-vetdsk48 253 13 in in IN cord-295206-vetdsk48 253 14 those those DT cord-295206-vetdsk48 253 15 with with IN cord-295206-vetdsk48 253 16 COP COP NNP cord-295206-vetdsk48 253 17 D. D. NNP cord-295206-vetdsk48 253 18 Clinical clinical JJ cord-295206-vetdsk48 253 19 trials trial NNS cord-295206-vetdsk48 253 20 of of IN cord-295206-vetdsk48 253 21 IL-10 IL-10 NNP cord-295206-vetdsk48 253 22 in in IN cord-295206-vetdsk48 253 23 various various JJ cord-295206-vetdsk48 253 24 inflammatory inflammatory JJ cord-295206-vetdsk48 253 25 disorders disorder NNS cord-295206-vetdsk48 253 26 are be VBP cord-295206-vetdsk48 253 27 underway underway JJ cord-295206-vetdsk48 253 28 . . . cord-295206-vetdsk48 254 1 IL-10 IL-10 NNP cord-295206-vetdsk48 254 2 may may MD cord-295206-vetdsk48 254 3 hold hold VB cord-295206-vetdsk48 254 4 promise promise NN cord-295206-vetdsk48 254 5 in in IN cord-295206-vetdsk48 254 6 chronic chronic JJ cord-295206-vetdsk48 254 7 bronchitis bronchitis NN cord-295206-vetdsk48 254 8 as as RB cord-295206-vetdsk48 254 9 well well RB cord-295206-vetdsk48 254 10 . . . cord-295206-vetdsk48 255 1 Interleukin-8 Interleukin-8 NNP cord-295206-vetdsk48 256 1 ( ( -LRB- cord-295206-vetdsk48 256 2 IL-8 IL-8 NNP cord-295206-vetdsk48 256 3 ) ) -RRB- cord-295206-vetdsk48 256 4 is be VBZ cord-295206-vetdsk48 256 5 a a DT cord-295206-vetdsk48 256 6 neutrophil neutrophil NN cord-295206-vetdsk48 256 7 - - HYPH cord-295206-vetdsk48 256 8 attracting attract VBG cord-295206-vetdsk48 256 9 cytokine cytokine NN cord-295206-vetdsk48 256 10 that that WDT cord-295206-vetdsk48 256 11 is be VBZ cord-295206-vetdsk48 256 12 elevated elevate VBN cord-295206-vetdsk48 256 13 in in IN cord-295206-vetdsk48 256 14 the the DT cord-295206-vetdsk48 256 15 sputum sputum NN cord-295206-vetdsk48 256 16 of of IN cord-295206-vetdsk48 256 17 persons person NNS cord-295206-vetdsk48 256 18 with with IN cord-295206-vetdsk48 256 19 COP COP NNP cord-295206-vetdsk48 256 20 D. D. NNP cord-295206-vetdsk48 256 21 Inhibitors Inhibitors NNP cord-295206-vetdsk48 256 22 of of IN cord-295206-vetdsk48 256 23 IL-8 IL-8 NNP cord-295206-vetdsk48 256 24 and and CC cord-295206-vetdsk48 256 25 antagonists antagonist NNS cord-295206-vetdsk48 256 26 of of IN cord-295206-vetdsk48 256 27 its -PRON- PRP$ cord-295206-vetdsk48 256 28 receptor receptor NN cord-295206-vetdsk48 256 29 , , , cord-295206-vetdsk48 256 30 CXCR2 CXCR2 NNS cord-295206-vetdsk48 256 31 , , , cord-295206-vetdsk48 256 32 are be VBP cord-295206-vetdsk48 256 33 being be VBG cord-295206-vetdsk48 256 34 developed develop VBN cord-295206-vetdsk48 256 35 and and CC cord-295206-vetdsk48 256 36 may may MD cord-295206-vetdsk48 256 37 be be VB cord-295206-vetdsk48 256 38 useful useful JJ cord-295206-vetdsk48 256 39 in in IN cord-295206-vetdsk48 256 40 the the DT cord-295206-vetdsk48 256 41 treatment treatment NN cord-295206-vetdsk48 256 42 of of IN cord-295206-vetdsk48 256 43 chronic chronic JJ cord-295206-vetdsk48 256 44 bronchitis bronchitis NN cord-295206-vetdsk48 256 45 . . . cord-295206-vetdsk48 257 1 Tumor tumor NN cord-295206-vetdsk48 257 2 necrosis necrosis NN cord-295206-vetdsk48 257 3 factor factor NN cord-295206-vetdsk48 257 4 - - HYPH cord-295206-vetdsk48 257 5 alpha alpha NN cord-295206-vetdsk48 257 6 ( ( -LRB- cord-295206-vetdsk48 257 7 TNF tnf NN cord-295206-vetdsk48 257 8 - - HYPH cord-295206-vetdsk48 257 9 alpha alpha NNP cord-295206-vetdsk48 257 10 ) ) -RRB- cord-295206-vetdsk48 257 11 is be VBZ cord-295206-vetdsk48 257 12 a a DT cord-295206-vetdsk48 257 13 pro pro JJ cord-295206-vetdsk48 257 14 - - JJ cord-295206-vetdsk48 257 15 inflammatory inflammatory JJ cord-295206-vetdsk48 257 16 cytokine cytokine NN cord-295206-vetdsk48 257 17 that that WDT cord-295206-vetdsk48 257 18 activates activate VBZ cord-295206-vetdsk48 257 19 various various JJ cord-295206-vetdsk48 257 20 immune immune JJ cord-295206-vetdsk48 257 21 cells cell NNS cord-295206-vetdsk48 257 22 and and CC cord-295206-vetdsk48 257 23 stimulates stimulate VBZ cord-295206-vetdsk48 257 24 the the DT cord-295206-vetdsk48 257 25 production production NN cord-295206-vetdsk48 257 26 of of IN cord-295206-vetdsk48 257 27 inflammatory inflammatory JJ cord-295206-vetdsk48 257 28 cytokines cytokine NNS cord-295206-vetdsk48 257 29 and and CC cord-295206-vetdsk48 257 30 other other JJ cord-295206-vetdsk48 257 31 mediators mediator NNS cord-295206-vetdsk48 257 32 . . . cord-295206-vetdsk48 258 1 Its -PRON- PRP$ cord-295206-vetdsk48 258 2 levels level NNS cord-295206-vetdsk48 258 3 are be VBP cord-295206-vetdsk48 258 4 elevated elevate VBN cord-295206-vetdsk48 258 5 in in IN cord-295206-vetdsk48 258 6 the the DT cord-295206-vetdsk48 258 7 sputum sputum NN cord-295206-vetdsk48 258 8 of of IN cord-295206-vetdsk48 258 9 individuals individual NNS cord-295206-vetdsk48 258 10 with with IN cord-295206-vetdsk48 258 11 COP COP NNP cord-295206-vetdsk48 258 12 D. D. NNP cord-295206-vetdsk48 258 13 Monoclonal Monoclonal NNP cord-295206-vetdsk48 258 14 antibodies antibody NNS cord-295206-vetdsk48 258 15 directed direct VBD cord-295206-vetdsk48 258 16 against against IN cord-295206-vetdsk48 258 17 TNF TNF NNP cord-295206-vetdsk48 258 18 - - HYPH cord-295206-vetdsk48 258 19 alpha alpha NN cord-295206-vetdsk48 258 20 , , , cord-295206-vetdsk48 258 21 such such JJ cord-295206-vetdsk48 258 22 as as IN cord-295206-vetdsk48 258 23 infliximab infliximab JJ cord-295206-vetdsk48 258 24 and and CC cord-295206-vetdsk48 258 25 recombinant recombinant JJ cord-295206-vetdsk48 258 26 soluble soluble JJ cord-295206-vetdsk48 258 27 TNFalpha TNFalpha NNS cord-295206-vetdsk48 258 28 receptor receptor NN cord-295206-vetdsk48 258 29 ( ( -LRB- cord-295206-vetdsk48 258 30 etanercept etanercept NNP cord-295206-vetdsk48 258 31 ) ) -RRB- cord-295206-vetdsk48 258 32 are be VBP cord-295206-vetdsk48 258 33 effective effective JJ cord-295206-vetdsk48 258 34 in in IN cord-295206-vetdsk48 258 35 rheumatoid rheumatoid NN cord-295206-vetdsk48 258 36 arthritis arthritis NN cord-295206-vetdsk48 258 37 and and CC cord-295206-vetdsk48 258 38 other other JJ cord-295206-vetdsk48 258 39 inflammatory inflammatory JJ cord-295206-vetdsk48 258 40 disorders disorder NNS cord-295206-vetdsk48 258 41 and and CC cord-295206-vetdsk48 258 42 may may MD cord-295206-vetdsk48 258 43 be be VB cord-295206-vetdsk48 258 44 useful useful JJ cord-295206-vetdsk48 258 45 in in IN cord-295206-vetdsk48 258 46 the the DT cord-295206-vetdsk48 258 47 management management NN cord-295206-vetdsk48 258 48 of of IN cord-295206-vetdsk48 258 49 chronic chronic JJ cord-295206-vetdsk48 258 50 bronchitis bronchitis NN cord-295206-vetdsk48 258 51 . . . cord-295206-vetdsk48 259 1 Inhibitors inhibitor NNS cord-295206-vetdsk48 259 2 of of IN cord-295206-vetdsk48 259 3 oxidative oxidative JJ cord-295206-vetdsk48 259 4 stress stress NN cord-295206-vetdsk48 259 5 N n CD cord-295206-vetdsk48 259 6 - - HYPH cord-295206-vetdsk48 259 7 acetylcysteine acetylcysteine NN cord-295206-vetdsk48 259 8 is be VBZ cord-295206-vetdsk48 259 9 a a DT cord-295206-vetdsk48 259 10 cysteine cysteine NN cord-295206-vetdsk48 259 11 donor donor NN cord-295206-vetdsk48 259 12 , , , cord-295206-vetdsk48 259 13 enhancing enhance VBG cord-295206-vetdsk48 259 14 the the DT cord-295206-vetdsk48 259 15 production production NN cord-295206-vetdsk48 259 16 of of IN cord-295206-vetdsk48 259 17 the the DT cord-295206-vetdsk48 259 18 antioxidant antioxidant JJ cord-295206-vetdsk48 259 19 glutathione glutathione NN cord-295206-vetdsk48 259 20 and and CC cord-295206-vetdsk48 259 21 decreasing decrease VBG cord-295206-vetdsk48 259 22 oxidative oxidative JJ cord-295206-vetdsk48 259 23 stress stress NN cord-295206-vetdsk48 259 24 . . . cord-295206-vetdsk48 260 1 It -PRON- PRP cord-295206-vetdsk48 260 2 has have VBZ cord-295206-vetdsk48 260 3 been be VBN cord-295206-vetdsk48 260 4 shown show VBN cord-295206-vetdsk48 260 5 to to TO cord-295206-vetdsk48 260 6 reduce reduce VB cord-295206-vetdsk48 260 7 the the DT cord-295206-vetdsk48 260 8 frequency frequency NN cord-295206-vetdsk48 260 9 of of IN cord-295206-vetdsk48 260 10 acute acute JJ cord-295206-vetdsk48 260 11 exacerbations exacerbation NNS cord-295206-vetdsk48 260 12 of of IN cord-295206-vetdsk48 260 13 chronic chronic JJ cord-295206-vetdsk48 260 14 bronchitis bronchitis NN cord-295206-vetdsk48 260 15 Wegner Wegner NNP cord-295206-vetdsk48 260 16 ( ( -LRB- cord-295206-vetdsk48 260 17 2001 2001 CD cord-295206-vetdsk48 260 18 ) ) -RRB- cord-295206-vetdsk48 260 19 . . . cord-295206-vetdsk48 261 1 Additional additional JJ cord-295206-vetdsk48 261 2 antioxidants antioxidant NNS cord-295206-vetdsk48 261 3 , , , cord-295206-vetdsk48 261 4 such such JJ cord-295206-vetdsk48 261 5 as as IN cord-295206-vetdsk48 261 6 stable stable JJ cord-295206-vetdsk48 261 7 glutathione glutathione NN cord-295206-vetdsk48 261 8 compounds compound NNS cord-295206-vetdsk48 261 9 and and CC cord-295206-vetdsk48 261 10 superoxide superoxide NN cord-295206-vetdsk48 261 11 dismutase dismutase NN cord-295206-vetdsk48 261 12 analogs analog NNS cord-295206-vetdsk48 261 13 , , , cord-295206-vetdsk48 261 14 are be VBP cord-295206-vetdsk48 261 15 in in IN cord-295206-vetdsk48 261 16 clinical clinical JJ cord-295206-vetdsk48 261 17 development development NN cord-295206-vetdsk48 261 18 . . . cord-295206-vetdsk48 262 1 Inducible inducible JJ cord-295206-vetdsk48 262 2 nitric nitric JJ cord-295206-vetdsk48 262 3 oxide oxide NN cord-295206-vetdsk48 262 4 synthetase synthetase NN cord-295206-vetdsk48 262 5 ( ( -LRB- cord-295206-vetdsk48 262 6 iNOS inos NN cord-295206-vetdsk48 262 7 ) ) -RRB- cord-295206-vetdsk48 262 8 is be VBZ cord-295206-vetdsk48 262 9 responsible responsible JJ cord-295206-vetdsk48 262 10 for for IN cord-295206-vetdsk48 262 11 the the DT cord-295206-vetdsk48 262 12 production production NN cord-295206-vetdsk48 262 13 of of IN cord-295206-vetdsk48 262 14 peroxynitrite peroxynitrite NN cord-295206-vetdsk48 262 15 , , , cord-295206-vetdsk48 262 16 a a DT cord-295206-vetdsk48 262 17 potent potent JJ cord-295206-vetdsk48 262 18 oxidative oxidative JJ cord-295206-vetdsk48 262 19 species specie NNS cord-295206-vetdsk48 262 20 released release VBN cord-295206-vetdsk48 262 21 during during IN cord-295206-vetdsk48 262 22 inflammation inflammation NN cord-295206-vetdsk48 262 23 . . . cord-295206-vetdsk48 263 1 Inhibitors inhibitor NNS cord-295206-vetdsk48 263 2 of of IN cord-295206-vetdsk48 263 3 iNOS ino NNS cord-295206-vetdsk48 263 4 are be VBP cord-295206-vetdsk48 263 5 under under IN cord-295206-vetdsk48 263 6 development development NN cord-295206-vetdsk48 263 7 and and CC cord-295206-vetdsk48 263 8 may may MD cord-295206-vetdsk48 263 9 be be VB cord-295206-vetdsk48 263 10 useful useful JJ cord-295206-vetdsk48 263 11 in in IN cord-295206-vetdsk48 263 12 the the DT cord-295206-vetdsk48 263 13 treatment treatment NN cord-295206-vetdsk48 263 14 of of IN cord-295206-vetdsk48 263 15 chronic chronic JJ cord-295206-vetdsk48 263 16 bronchitis bronchitis NN cord-295206-vetdsk48 263 17 . . . cord-295206-vetdsk48 264 1 Inhibitors inhibitor NNS cord-295206-vetdsk48 264 2 of of IN cord-295206-vetdsk48 264 3 proteases protease NNS cord-295206-vetdsk48 264 4 ( ( -LRB- cord-295206-vetdsk48 264 5 e.g. e.g. RB cord-295206-vetdsk48 264 6 , , , cord-295206-vetdsk48 264 7 elastase elastase NN cord-295206-vetdsk48 264 8 ) ) -RRB- cord-295206-vetdsk48 264 9 that that WDT cord-295206-vetdsk48 264 10 are be VBP cord-295206-vetdsk48 264 11 released release VBN cord-295206-vetdsk48 264 12 by by IN cord-295206-vetdsk48 264 13 neutrophils neutrophil NNS cord-295206-vetdsk48 264 14 during during IN cord-295206-vetdsk48 264 15 the the DT cord-295206-vetdsk48 264 16 inflammatory inflammatory JJ cord-295206-vetdsk48 264 17 processes process NNS cord-295206-vetdsk48 264 18 of of IN cord-295206-vetdsk48 264 19 chronic chronic JJ cord-295206-vetdsk48 264 20 obstructive obstructive JJ cord-295206-vetdsk48 264 21 pulmonary pulmonary JJ cord-295206-vetdsk48 264 22 disease disease NN cord-295206-vetdsk48 264 23 are be VBP cord-295206-vetdsk48 264 24 under under IN cord-295206-vetdsk48 264 25 development development NN cord-295206-vetdsk48 264 26 Barnes Barnes NNP cord-295206-vetdsk48 264 27 ( ( -LRB- cord-295206-vetdsk48 264 28 2003 2003 CD cord-295206-vetdsk48 264 29 ) ) -RRB- cord-295206-vetdsk48 264 30 . . . cord-295206-vetdsk48 265 1 These these DT cord-295206-vetdsk48 265 2 compounds compound NNS cord-295206-vetdsk48 265 3 may may MD cord-295206-vetdsk48 265 4 slow slow VB cord-295206-vetdsk48 265 5 the the DT cord-295206-vetdsk48 265 6 progression progression NN cord-295206-vetdsk48 265 7 of of IN cord-295206-vetdsk48 265 8 emphysema emphysema NN cord-295206-vetdsk48 265 9 that that WDT cord-295206-vetdsk48 265 10 accompanies accompany VBZ cord-295206-vetdsk48 265 11 certain certain JJ cord-295206-vetdsk48 265 12 cases case NNS cord-295206-vetdsk48 265 13 of of IN cord-295206-vetdsk48 265 14 chronic chronic JJ cord-295206-vetdsk48 265 15 bronchitis bronchitis NN cord-295206-vetdsk48 265 16 . . . cord-295206-vetdsk48 266 1 The the DT cord-295206-vetdsk48 266 2 p38 p38 CD cord-295206-vetdsk48 266 3 mitogen mitogen NN cord-295206-vetdsk48 266 4 - - HYPH cord-295206-vetdsk48 266 5 activated activate VBN cord-295206-vetdsk48 266 6 protein protein NN cord-295206-vetdsk48 266 7 ( ( -LRB- cord-295206-vetdsk48 266 8 MAP MAP NNP cord-295206-vetdsk48 266 9 ) ) -RRB- cord-295206-vetdsk48 266 10 kinase kinase NN cord-295206-vetdsk48 266 11 is be VBZ cord-295206-vetdsk48 266 12 involved involve VBN cord-295206-vetdsk48 266 13 in in IN cord-295206-vetdsk48 266 14 the the DT cord-295206-vetdsk48 266 15 expression expression NN cord-295206-vetdsk48 266 16 of of IN cord-295206-vetdsk48 266 17 inflammatory inflammatory JJ cord-295206-vetdsk48 266 18 cytokines cytokine NNS cord-295206-vetdsk48 266 19 and and CC cord-295206-vetdsk48 266 20 proteases protease NNS cord-295206-vetdsk48 266 21 involved involve VBN cord-295206-vetdsk48 266 22 in in IN cord-295206-vetdsk48 266 23 chronic chronic JJ cord-295206-vetdsk48 266 24 bronchitis bronchitis NN cord-295206-vetdsk48 266 25 . . . cord-295206-vetdsk48 267 1 Inhibitors Inhibitors NNP cord-295206-vetdsk48 267 2 of of IN cord-295206-vetdsk48 267 3 MAP MAP NNP cord-295206-vetdsk48 267 4 kinase kinase NN cord-295206-vetdsk48 267 5 have have VBP cord-295206-vetdsk48 267 6 been be VBN cord-295206-vetdsk48 267 7 developed develop VBN cord-295206-vetdsk48 267 8 and and CC cord-295206-vetdsk48 267 9 may may MD cord-295206-vetdsk48 267 10 be be VB cord-295206-vetdsk48 267 11 useful useful JJ cord-295206-vetdsk48 267 12 in in IN cord-295206-vetdsk48 267 13 treating treat VBG cord-295206-vetdsk48 267 14 chronic chronic JJ cord-295206-vetdsk48 267 15 bronchitis bronchitis NN cord-295206-vetdsk48 267 16 Barnes Barnes NNP cord-295206-vetdsk48 267 17 ( ( -LRB- cord-295206-vetdsk48 267 18 2003 2003 CD cord-295206-vetdsk48 267 19 ) ) -RRB- cord-295206-vetdsk48 267 20 . . . cord-295206-vetdsk48 268 1 Inhibitors Inhibitors NNP cord-295206-vetdsk48 268 2 of of IN cord-295206-vetdsk48 268 3 phosphoinositide-3 phosphoinositide-3 NNP cord-295206-vetdsk48 268 4 kinase kinase NN cord-295206-vetdsk48 268 5 - - HYPH cord-295206-vetdsk48 268 6 gamma gamma NN cord-295206-vetdsk48 268 7 ( ( -LRB- cord-295206-vetdsk48 268 8 PI-3Kgamma PI-3Kgamma NNP cord-295206-vetdsk48 268 9 ) ) -RRB- cord-295206-vetdsk48 268 10 , , , cord-295206-vetdsk48 268 11 an an DT cord-295206-vetdsk48 268 12 enzyme enzyme NN cord-295206-vetdsk48 268 13 involved involve VBN cord-295206-vetdsk48 268 14 in in IN cord-295206-vetdsk48 268 15 neutrophil neutrophil NN cord-295206-vetdsk48 268 16 activation activation NN cord-295206-vetdsk48 268 17 , , , cord-295206-vetdsk48 268 18 may may MD cord-295206-vetdsk48 268 19 also also RB cord-295206-vetdsk48 268 20 be be VB cord-295206-vetdsk48 268 21 of of IN cord-295206-vetdsk48 268 22 value value NN cord-295206-vetdsk48 268 23 . . . cord-295206-vetdsk48 269 1 Inhibitors inhibitor NNS cord-295206-vetdsk48 269 2 of of IN cord-295206-vetdsk48 269 3 the the DT cord-295206-vetdsk48 269 4 NF NF NNP cord-295206-vetdsk48 269 5 - - HYPH cord-295206-vetdsk48 269 6 kappaB kappaB NNP cord-295206-vetdsk48 269 7 signaling signal VBG cord-295206-vetdsk48 269 8 pathway pathway NN cord-295206-vetdsk48 269 9 are be VBP cord-295206-vetdsk48 269 10 in in IN cord-295206-vetdsk48 269 11 development development NN cord-295206-vetdsk48 269 12 and and CC cord-295206-vetdsk48 269 13 may may MD cord-295206-vetdsk48 269 14 be be VB cord-295206-vetdsk48 269 15 tested test VBN cord-295206-vetdsk48 269 16 for for IN cord-295206-vetdsk48 269 17 the the DT cord-295206-vetdsk48 269 18 treatment treatment NN cord-295206-vetdsk48 269 19 of of IN cord-295206-vetdsk48 269 20 chronic chronic JJ cord-295206-vetdsk48 269 21 bronchitis bronchitis NN cord-295206-vetdsk48 269 22 . . . cord-295206-vetdsk48 270 1 Models model NNS cord-295206-vetdsk48 270 2 of of IN cord-295206-vetdsk48 270 3 acute acute JJ cord-295206-vetdsk48 270 4 infectious infectious JJ cord-295206-vetdsk48 270 5 bronchitis bronchitis NN cord-295206-vetdsk48 270 6 involve involve VBP cord-295206-vetdsk48 270 7 animals animal NNS cord-295206-vetdsk48 270 8 infected infect VBN cord-295206-vetdsk48 270 9 with with IN cord-295206-vetdsk48 270 10 a a DT cord-295206-vetdsk48 270 11 causative causative JJ cord-295206-vetdsk48 270 12 viral viral JJ cord-295206-vetdsk48 270 13 agent agent NN cord-295206-vetdsk48 270 14 . . . cord-295206-vetdsk48 271 1 For for IN cord-295206-vetdsk48 271 2 example example NN cord-295206-vetdsk48 271 3 , , , cord-295206-vetdsk48 271 4 mice mouse NNS cord-295206-vetdsk48 271 5 , , , cord-295206-vetdsk48 271 6 ferrets ferret NNS cord-295206-vetdsk48 271 7 , , , cord-295206-vetdsk48 271 8 and and CC cord-295206-vetdsk48 271 9 chickens chicken NNS cord-295206-vetdsk48 271 10 infected infect VBN cord-295206-vetdsk48 271 11 with with IN cord-295206-vetdsk48 271 12 influenza influenza NN cord-295206-vetdsk48 271 13 viruses virus NNS cord-295206-vetdsk48 271 14 are be VBP cord-295206-vetdsk48 271 15 commonly commonly RB cord-295206-vetdsk48 271 16 used use VBN cord-295206-vetdsk48 271 17 in in IN cord-295206-vetdsk48 271 18 the the DT cord-295206-vetdsk48 271 19 search search NN cord-295206-vetdsk48 271 20 for for IN cord-295206-vetdsk48 271 21 new new JJ cord-295206-vetdsk48 271 22 anti anti JJ cord-295206-vetdsk48 271 23 - - JJ cord-295206-vetdsk48 271 24 influenza influenza JJ cord-295206-vetdsk48 271 25 drugs drug NNS cord-295206-vetdsk48 271 26 Sidwell Sidwell NNP cord-295206-vetdsk48 271 27 and and CC cord-295206-vetdsk48 271 28 Smee Smee NNP cord-295206-vetdsk48 271 29 ( ( -LRB- cord-295206-vetdsk48 271 30 2000 2000 CD cord-295206-vetdsk48 271 31 ) ) -RRB- cord-295206-vetdsk48 271 32 . . . cord-295206-vetdsk48 272 1 A a DT cord-295206-vetdsk48 272 2 number number NN cord-295206-vetdsk48 272 3 of of IN cord-295206-vetdsk48 272 4 animal animal NN cord-295206-vetdsk48 272 5 models model NNS cord-295206-vetdsk48 272 6 are be VBP cord-295206-vetdsk48 272 7 commonly commonly RB cord-295206-vetdsk48 272 8 employed employ VBN cord-295206-vetdsk48 272 9 in in IN cord-295206-vetdsk48 272 10 the the DT cord-295206-vetdsk48 272 11 study study NN cord-295206-vetdsk48 272 12 of of IN cord-295206-vetdsk48 272 13 chronic chronic JJ cord-295206-vetdsk48 272 14 bronchitis bronchitis NN cord-295206-vetdsk48 272 15 Nikula Nikula NNP cord-295206-vetdsk48 272 16 and and CC cord-295206-vetdsk48 272 17 Green Green NNP cord-295206-vetdsk48 272 18 ( ( -LRB- cord-295206-vetdsk48 272 19 2000 2000 CD cord-295206-vetdsk48 272 20 ) ) -RRB- cord-295206-vetdsk48 272 21 . . . cord-295206-vetdsk48 273 1 Hamsters hamster NNS cord-295206-vetdsk48 273 2 , , , cord-295206-vetdsk48 273 3 dogs dog NNS cord-295206-vetdsk48 273 4 , , , cord-295206-vetdsk48 273 5 or or CC cord-295206-vetdsk48 273 6 rats rat NNS cord-295206-vetdsk48 273 7 exposed expose VBN cord-295206-vetdsk48 273 8 to to IN cord-295206-vetdsk48 273 9 sulfur sulfur NN cord-295206-vetdsk48 273 10 dioxide dioxide NN cord-295206-vetdsk48 273 11 ( ( -LRB- cord-295206-vetdsk48 273 12 SO so RB cord-295206-vetdsk48 273 13 2 2 CD cord-295206-vetdsk48 273 14 ) ) -RRB- cord-295206-vetdsk48 273 15 for for IN cord-295206-vetdsk48 273 16 3 3 CD cord-295206-vetdsk48 273 17 - - SYM cord-295206-vetdsk48 273 18 6 6 CD cord-295206-vetdsk48 273 19 weeks week NNS cord-295206-vetdsk48 273 20 develop develop VBP cord-295206-vetdsk48 273 21 clinical clinical JJ cord-295206-vetdsk48 273 22 and and CC cord-295206-vetdsk48 273 23 histological histological JJ cord-295206-vetdsk48 273 24 signs sign NNS cord-295206-vetdsk48 273 25 of of IN cord-295206-vetdsk48 273 26 chronic chronic JJ cord-295206-vetdsk48 273 27 bronchitis bronchitis NN cord-295206-vetdsk48 273 28 . . . cord-295206-vetdsk48 274 1 Mice mouse NNS cord-295206-vetdsk48 274 2 , , , cord-295206-vetdsk48 274 3 rats rat NNS cord-295206-vetdsk48 274 4 , , , cord-295206-vetdsk48 274 5 guinea guinea NN cord-295206-vetdsk48 274 6 pigs pig NNS cord-295206-vetdsk48 274 7 , , , cord-295206-vetdsk48 274 8 dogs dog NNS cord-295206-vetdsk48 274 9 , , , cord-295206-vetdsk48 274 10 sheep sheep NN cord-295206-vetdsk48 274 11 , , , cord-295206-vetdsk48 274 12 and and CC cord-295206-vetdsk48 274 13 monkeys monkey NNS cord-295206-vetdsk48 274 14 have have VBP cord-295206-vetdsk48 274 15 been be VBN cord-295206-vetdsk48 274 16 used use VBN cord-295206-vetdsk48 274 17 to to TO cord-295206-vetdsk48 274 18 study study VB cord-295206-vetdsk48 274 19 the the DT cord-295206-vetdsk48 274 20 role role NN cord-295206-vetdsk48 274 21 of of IN cord-295206-vetdsk48 274 22 cigarette cigarette NN cord-295206-vetdsk48 274 23 smoke smoke NN cord-295206-vetdsk48 274 24 in in IN cord-295206-vetdsk48 274 25 the the DT cord-295206-vetdsk48 274 26 development development NN cord-295206-vetdsk48 274 27 of of IN cord-295206-vetdsk48 274 28 chronic chronic JJ cord-295206-vetdsk48 274 29 bronchitis bronchitis NN cord-295206-vetdsk48 274 30 and and CC cord-295206-vetdsk48 274 31 emphysema emphysema NN cord-295206-vetdsk48 274 32 . . . cord-295206-vetdsk48 275 1 Rats rat NNS cord-295206-vetdsk48 275 2 , , , cord-295206-vetdsk48 275 3 mice mouse NNS cord-295206-vetdsk48 275 4 , , , cord-295206-vetdsk48 275 5 hamsters hamster NNS cord-295206-vetdsk48 275 6 , , , cord-295206-vetdsk48 275 7 and and CC cord-295206-vetdsk48 275 8 guinea guinea NN cord-295206-vetdsk48 275 9 pigs pig NNS cord-295206-vetdsk48 275 10 exposed expose VBN cord-295206-vetdsk48 275 11 to to IN cord-295206-vetdsk48 275 12 organic organic JJ cord-295206-vetdsk48 275 13 dusts dust NNS cord-295206-vetdsk48 275 14 ( ( -LRB- cord-295206-vetdsk48 275 15 e.g. e.g. RB cord-295206-vetdsk48 275 16 , , , cord-295206-vetdsk48 275 17 cotton cotton NN cord-295206-vetdsk48 275 18 dust dust NN cord-295206-vetdsk48 275 19 ) ) -RRB- cord-295206-vetdsk48 275 20 and and CC cord-295206-vetdsk48 275 21 bacterial bacterial JJ cord-295206-vetdsk48 275 22 endotoxin endotoxin NN cord-295206-vetdsk48 275 23 have have VBP cord-295206-vetdsk48 275 24 been be VBN cord-295206-vetdsk48 275 25 used use VBN cord-295206-vetdsk48 275 26 to to TO cord-295206-vetdsk48 275 27 model model VB cord-295206-vetdsk48 275 28 occupational occupational JJ cord-295206-vetdsk48 275 29 exposures exposure NNS cord-295206-vetdsk48 275 30 , , , cord-295206-vetdsk48 275 31 which which WDT cord-295206-vetdsk48 275 32 result result VBP cord-295206-vetdsk48 275 33 in in IN cord-295206-vetdsk48 275 34 chronic chronic JJ cord-295206-vetdsk48 275 35 bronchitis bronchitis NN cord-295206-vetdsk48 275 36 and and CC cord-295206-vetdsk48 275 37 other other JJ cord-295206-vetdsk48 275 38 forms form NNS cord-295206-vetdsk48 275 39 of of IN cord-295206-vetdsk48 275 40 lung lung NN cord-295206-vetdsk48 275 41 inflammation inflammation NN cord-295206-vetdsk48 275 42 . . . cord-295206-vetdsk48 276 1 Exposure exposure NN cord-295206-vetdsk48 276 2 to to IN cord-295206-vetdsk48 276 3 other other JJ cord-295206-vetdsk48 276 4 substances substance NNS cord-295206-vetdsk48 276 5 such such JJ cord-295206-vetdsk48 276 6 as as IN cord-295206-vetdsk48 276 7 nickel nickel NN cord-295206-vetdsk48 276 8 and and CC cord-295206-vetdsk48 276 9 nitric nitric NN cord-295206-vetdsk48 276 10 acid acid NN cord-295206-vetdsk48 276 11 has have VBZ cord-295206-vetdsk48 276 12 also also RB cord-295206-vetdsk48 276 13 been be VBN cord-295206-vetdsk48 276 14 examined examine VBN cord-295206-vetdsk48 276 15 . . . cord-295206-vetdsk48 277 1 Lazarus Lazarus NNP cord-295206-vetdsk48 277 2 , , , cord-295206-vetdsk48 277 3 S.J. S.J. NNP cord-295206-vetdsk48 277 4 , , , cord-295206-vetdsk48 277 5 Experts expert NNS cord-295206-vetdsk48 277 6 strive strive VBP cord-295206-vetdsk48 277 7 to to TO cord-295206-vetdsk48 277 8 better better RB cord-295206-vetdsk48 277 9 define define VB cord-295206-vetdsk48 277 10 the the DT cord-295206-vetdsk48 277 11 pathophysiology pathophysiology NN cord-295206-vetdsk48 277 12 of of IN cord-295206-vetdsk48 277 13 COP cop NN cord-295206-vetdsk48 277 14 D. D. NNP cord-295206-vetdsk48 277 15 This this DT cord-295206-vetdsk48 277 16 article article NN cord-295206-vetdsk48 277 17 examines examine VBZ cord-295206-vetdsk48 277 18 new new JJ cord-295206-vetdsk48 277 19 directions direction NNS cord-295206-vetdsk48 277 20 in in IN cord-295206-vetdsk48 277 21 the the DT cord-295206-vetdsk48 277 22 study study NN cord-295206-vetdsk48 277 23 of of IN cord-295206-vetdsk48 277 24 COPD COPD NNP cord-295206-vetdsk48 277 25 pathology pathology NN cord-295206-vetdsk48 277 26 : : : cord-295206-vetdsk48 277 27 http://www.medscape.com/ http://www.medscape.com/ ADD cord-295206-vetdsk48 277 28 viewarticle/464534 viewarticle/464534 NNS cord-295206-vetdsk48 278 1 Croxton Croxton NNP cord-295206-vetdsk48 278 2 , , , cord-295206-vetdsk48 278 3 T.L. T.L. NNP cord-295206-vetdsk48 278 4 , , , cord-295206-vetdsk48 278 5 Weinmann Weinmann NNP cord-295206-vetdsk48 278 6 , , , cord-295206-vetdsk48 278 7 G.G. G.G. NNP cord-295206-vetdsk48 278 8 , , , cord-295206-vetdsk48 278 9 Senior Senior NNP cord-295206-vetdsk48 278 10 , , , cord-295206-vetdsk48 278 11 R.M. R.M. NNP cord-295206-vetdsk48 278 12 , , , cord-295206-vetdsk48 278 13 Wise Wise NNP cord-295206-vetdsk48 278 14 , , , cord-295206-vetdsk48 278 15 R.A. R.A. NNP cord-295206-vetdsk48 278 16 , , , cord-295206-vetdsk48 278 17 Crapo Crapo NNP cord-295206-vetdsk48 278 18 , , , cord-295206-vetdsk48 278 19 J. J. NNP cord-295206-vetdsk48 278 20 D. D. NNP cord-295206-vetdsk48 278 21 and and CC cord-295206-vetdsk48 278 22 Buist Buist NNP cord-295206-vetdsk48 278 23 , , , cord-295206-vetdsk48 278 24 A.S. A.S. NNP cord-295206-vetdsk48 278 25 , , , cord-295206-vetdsk48 278 26 Clinical clinical JJ cord-295206-vetdsk48 278 27 research research NN cord-295206-vetdsk48 278 28 in in IN cord-295206-vetdsk48 278 29 chronic chronic JJ cord-295206-vetdsk48 278 30 obstructive obstructive JJ cord-295206-vetdsk48 278 31 pulmonary pulmonary JJ cord-295206-vetdsk48 278 32 disease disease NN cord-295206-vetdsk48 278 33 : : : cord-295206-vetdsk48 278 34 needs need NNS cord-295206-vetdsk48 278 35 and and CC cord-295206-vetdsk48 278 36 opportunities opportunity NNS cord-295206-vetdsk48 278 37 : : : cord-295206-vetdsk48 278 38 http://www.nhlbi.nih.gov/meetings/workshops/copd_clinical.htm http://www.nhlbi.nih.gov/meetings/workshops/copd_clinical.htm ADD cord-295206-vetdsk48 278 39 United United NNP cord-295206-vetdsk48 278 40 States States NNP cord-295206-vetdsk48 278 41 Department Department NNP cord-295206-vetdsk48 278 42 of of IN cord-295206-vetdsk48 278 43 Health Health NNP cord-295206-vetdsk48 278 44 and and CC cord-295206-vetdsk48 278 45 Human Human NNP cord-295206-vetdsk48 278 46 Services Services NNPS cord-295206-vetdsk48 278 47 , , , cord-295206-vetdsk48 278 48 CDC CDC NNP cord-295206-vetdsk48 278 49 , , , cord-295206-vetdsk48 278 50 NCH NCH NNP cord-295206-vetdsk48 278 51 S. S. NNP cord-295206-vetdsk48 278 52 2001 2001 CD cord-295206-vetdsk48 278 53 National National NNP cord-295206-vetdsk48 278 54 Health Health NNP cord-295206-vetdsk48 278 55 Interview Interview NNP cord-295206-vetdsk48 278 56 Survey Survey NNP cord-295206-vetdsk48 278 57 . . . cord-295206-vetdsk48 279 1 This this DT cord-295206-vetdsk48 279 2 web web NN cord-295206-vetdsk48 279 3 site site NN cord-295206-vetdsk48 279 4 contains contain VBZ cord-295206-vetdsk48 279 5 data datum NNS cord-295206-vetdsk48 279 6 on on IN cord-295206-vetdsk48 279 7 the the DT cord-295206-vetdsk48 279 8 prevalence prevalence NN cord-295206-vetdsk48 279 9 of of IN cord-295206-vetdsk48 279 10 COPD COPD NNP cord-295206-vetdsk48 279 11 symptoms symptom NNS cord-295206-vetdsk48 279 12 in in IN cord-295206-vetdsk48 279 13 the the DT cord-295206-vetdsk48 279 14 United United NNP cord-295206-vetdsk48 279 15 States States NNP cord-295206-vetdsk48 279 16 and and CC cord-295206-vetdsk48 279 17 their -PRON- PRP$ cord-295206-vetdsk48 279 18 impact impact NN cord-295206-vetdsk48 279 19 on on IN cord-295206-vetdsk48 279 20 activity activity NN cord-295206-vetdsk48 279 21 and and CC cord-295206-vetdsk48 279 22 daily daily JJ cord-295206-vetdsk48 279 23 life life NN cord-295206-vetdsk48 279 24 . . . cord-295206-vetdsk48 280 1 It -PRON- PRP cord-295206-vetdsk48 280 2 also also RB cord-295206-vetdsk48 280 3 has have VBZ cord-295206-vetdsk48 280 4 epidemiological epidemiological JJ cord-295206-vetdsk48 280 5 information information NN cord-295206-vetdsk48 280 6 on on IN cord-295206-vetdsk48 280 7 a a DT cord-295206-vetdsk48 280 8 number number NN cord-295206-vetdsk48 280 9 of of IN cord-295206-vetdsk48 280 10 other other JJ cord-295206-vetdsk48 280 11 medical medical JJ cord-295206-vetdsk48 280 12 conditions condition NNS cord-295206-vetdsk48 280 13 : : : cord-295206-vetdsk48 280 14 http://www.cdc http://www.cdc ADD cord-295206-vetdsk48 280 15 . . . cord-295206-vetdsk48 281 1 gov/ gov/ NFP cord-295206-vetdsk48 282 1 nchs/ nchs/ CD cord-295206-vetdsk48 283 1 nhis.htm nhis.htm ADD cord-295206-vetdsk48 283 2 Bandi Bandi NNP cord-295206-vetdsk48 283 3 , , , cord-295206-vetdsk48 283 4 V.A. V.A. NNP cord-295206-vetdsk48 283 5 , , , cord-295206-vetdsk48 283 6 Apicella Apicella NNP cord-295206-vetdsk48 283 7 , , , cord-295206-vetdsk48 283 8 M.A. M.A. NNP cord-295206-vetdsk48 283 9 , , , cord-295206-vetdsk48 283 10 Mason Mason NNP cord-295206-vetdsk48 283 11 , , , cord-295206-vetdsk48 283 12 E. E. NNP cord-295206-vetdsk48 283 13 , , , cord-295206-vetdsk48 283 14 Murphy Murphy NNP cord-295206-vetdsk48 283 15 , , , cord-295206-vetdsk48 283 16 T.F. T.F. NNP cord-295206-vetdsk48 283 17 , , , cord-295206-vetdsk48 283 18 Siddiqi Siddiqi NNP cord-295206-vetdsk48 283 19 , , , cord-295206-vetdsk48 283 20 A. A. NNP cord-295206-vetdsk48 283 21 , , , cord-295206-vetdsk48 283 22 Atmar Atmar NNP cord-295206-vetdsk48 283 23 , , , cord-295206-vetdsk48 283 24 R.L. R.L. NNP cord-295206-vetdsk48 283 25 , , , cord-295206-vetdsk48 283 26 Greenberg Greenberg NNP cord-295206-vetdsk48 283 27 , , , cord-295206-vetdsk48 283 28 S.G. S.G. NNP cord-295206-vetdsk48 283 29 , , , cord-295206-vetdsk48 283 30 2001 2001 CD cord-295206-vetdsk48 283 31 . . . cord-295206-vetdsk48 284 1 Nontypeable nontypeable JJ cord-295206-vetdsk48 284 2 Haemophilus Haemophilus NNP cord-295206-vetdsk48 284 3 influenzae influenzae NN cord-295206-vetdsk48 284 4 in in IN cord-295206-vetdsk48 284 5 the the DT cord-295206-vetdsk48 284 6 lower low JJR cord-295206-vetdsk48 284 7 respiratory respiratory JJ cord-295206-vetdsk48 284 8 tract tract NN cord-295206-vetdsk48 284 9 of of IN cord-295206-vetdsk48 284 10 patients patient NNS cord-295206-vetdsk48 284 11 with with IN cord-295206-vetdsk48 284 12 chronic chronic JJ cord-295206-vetdsk48 284 13 bronchitis bronchitis NN cord-295206-vetdsk48 284 14 . . . cord-295206-vetdsk48 285 1 Am be VBP cord-295206-vetdsk48 285 2 . . . cord-295206-vetdsk48 286 1 J. J. NNP cord-295206-vetdsk48 286 2 Respir Respir NNP cord-295206-vetdsk48 286 3 . . . cord-295206-vetdsk48 287 1 Crit crit NN cord-295206-vetdsk48 287 2 . . . cord-295206-vetdsk48 288 1 Care Care NNP cord-295206-vetdsk48 288 2 Med Med NNP cord-295206-vetdsk48 288 3 . . NNP cord-295206-vetdsk48 288 4 , , , cord-295206-vetdsk48 288 5 164 164 CD cord-295206-vetdsk48 288 6 , , , cord-295206-vetdsk48 288 7 2114 2114 CD cord-295206-vetdsk48 288 8 - - SYM cord-295206-vetdsk48 288 9 2119 2119 CD cord-295206-vetdsk48 288 10 . . . cord-295206-vetdsk48 289 1 Chronic chronic JJ cord-295206-vetdsk48 289 2 obstructive obstructive JJ cord-295206-vetdsk48 289 3 pulmonary pulmonary JJ cord-295206-vetdsk48 289 4 disease disease NN cord-295206-vetdsk48 289 5 12 12 CD cord-295206-vetdsk48 289 6 : : : cord-295206-vetdsk48 289 7 new new JJ cord-295206-vetdsk48 289 8 treatments treatment NNS cord-295206-vetdsk48 289 9 for for IN cord-295206-vetdsk48 289 10 COPD COPD NNP cord-295206-vetdsk48 289 11 Population Population NNP cord-295206-vetdsk48 289 12 : : : cord-295206-vetdsk48 289 13 National National NNP cord-295206-vetdsk48 289 14 Health Health NNP cord-295206-vetdsk48 289 15 Interview Interview NNP cord-295206-vetdsk48 289 16 Survey Survey NNP cord-295206-vetdsk48 289 17 Antibiotics Antibiotics NNPS cord-295206-vetdsk48 289 18 in in IN cord-295206-vetdsk48 289 19 acute acute JJ cord-295206-vetdsk48 289 20 bronchitis bronchitis NN cord-295206-vetdsk48 289 21 : : : cord-295206-vetdsk48 290 1 a a DT cord-295206-vetdsk48 290 2 meta meta NNP cord-295206-vetdsk48 290 3 - - HYPH cord-295206-vetdsk48 290 4 analysis analysis NN cord-295206-vetdsk48 290 5 Recent recent JJ cord-295206-vetdsk48 290 6 advances advance NNS cord-295206-vetdsk48 290 7 in in IN cord-295206-vetdsk48 290 8 diagnosis diagnosis NN cord-295206-vetdsk48 290 9 and and CC cord-295206-vetdsk48 290 10 management management NN cord-295206-vetdsk48 290 11 of of IN cord-295206-vetdsk48 290 12 chronic chronic JJ cord-295206-vetdsk48 290 13 bronchitis bronchitis NN cord-295206-vetdsk48 290 14 and and CC cord-295206-vetdsk48 290 15 emphysema emphysema NN cord-295206-vetdsk48 290 16 Disease Disease NNP cord-295206-vetdsk48 290 17 of of IN cord-295206-vetdsk48 290 18 the the DT cord-295206-vetdsk48 290 19 airways airways NNPS cord-295206-vetdsk48 290 20 in in IN cord-295206-vetdsk48 290 21 chronic chronic JJ cord-295206-vetdsk48 290 22 obstructive obstructive JJ cord-295206-vetdsk48 290 23 pulmonary pulmonary JJ cord-295206-vetdsk48 290 24 disease disease NN cord-295206-vetdsk48 291 1 Quantitative quantitative JJ cord-295206-vetdsk48 291 2 systematic systematic JJ cord-295206-vetdsk48 291 3 review review NN cord-295206-vetdsk48 291 4 of of IN cord-295206-vetdsk48 291 5 randomised randomised JJ cord-295206-vetdsk48 291 6 controlled control VBN cord-295206-vetdsk48 291 7 trials trial NNS cord-295206-vetdsk48 291 8 comparing compare VBG cord-295206-vetdsk48 291 9 antibiotic antibiotic NN cord-295206-vetdsk48 291 10 with with IN cord-295206-vetdsk48 291 11 placebo placebo NN cord-295206-vetdsk48 291 12 for for IN cord-295206-vetdsk48 291 13 acute acute JJ cord-295206-vetdsk48 291 14 cough cough NN cord-295206-vetdsk48 291 15 in in IN cord-295206-vetdsk48 291 16 adults adult NNS cord-295206-vetdsk48 292 1 The the DT cord-295206-vetdsk48 292 2 epidemiology epidemiology NN cord-295206-vetdsk48 292 3 of of IN cord-295206-vetdsk48 292 4 respiratory respiratory JJ cord-295206-vetdsk48 292 5 tract tract NN cord-295206-vetdsk48 292 6 infections infection NNS cord-295206-vetdsk48 292 7 Antiinflammatory antiinflammatory JJ cord-295206-vetdsk48 292 8 effects effect NNS cord-295206-vetdsk48 292 9 of of IN cord-295206-vetdsk48 292 10 the the DT cord-295206-vetdsk48 292 11 phosphodiesterase-4 phosphodiesterase-4 NNP cord-295206-vetdsk48 292 12 inhibitor inhibitor NN cord-295206-vetdsk48 292 13 cilomilast cilomilast NN cord-295206-vetdsk48 292 14 ( ( -LRB- cord-295206-vetdsk48 292 15 Ariflo Ariflo NNP cord-295206-vetdsk48 292 16 ) ) -RRB- cord-295206-vetdsk48 292 17 in in IN cord-295206-vetdsk48 292 18 chronic chronic JJ cord-295206-vetdsk48 292 19 obstructive obstructive JJ cord-295206-vetdsk48 292 20 pulmonary pulmonary JJ cord-295206-vetdsk48 292 21 disease disease NN cord-295206-vetdsk48 292 22 Viral viral JJ cord-295206-vetdsk48 292 23 and and CC cord-295206-vetdsk48 292 24 bacterial bacterial JJ cord-295206-vetdsk48 292 25 infections infection NNS cord-295206-vetdsk48 292 26 in in IN cord-295206-vetdsk48 292 27 the the DT cord-295206-vetdsk48 292 28 development development NN cord-295206-vetdsk48 292 29 and and CC cord-295206-vetdsk48 292 30 progression progression NN cord-295206-vetdsk48 292 31 of of IN cord-295206-vetdsk48 292 32 asthma asthma NN cord-295206-vetdsk48 292 33 Cilomilast Cilomilast NNP cord-295206-vetdsk48 292 34 : : : cord-295206-vetdsk48 292 35 a a DT cord-295206-vetdsk48 292 36 second second JJ cord-295206-vetdsk48 292 37 generation generation NN cord-295206-vetdsk48 292 38 phosphodiesterase phosphodiesterase NN cord-295206-vetdsk48 292 39 4 4 CD cord-295206-vetdsk48 292 40 inhibitor inhibitor NN cord-295206-vetdsk48 292 41 for for IN cord-295206-vetdsk48 292 42 asthma asthma NN cord-295206-vetdsk48 292 43 and and CC cord-295206-vetdsk48 292 44 chronic chronic JJ cord-295206-vetdsk48 292 45 obstructive obstructive JJ cord-295206-vetdsk48 292 46 pulmonary pulmonary JJ cord-295206-vetdsk48 292 47 disease disease NN cord-295206-vetdsk48 292 48 Principles principle NNS cord-295206-vetdsk48 292 49 of of IN cord-295206-vetdsk48 292 50 appropriate appropriate JJ cord-295206-vetdsk48 292 51 antibiotic antibiotic JJ cord-295206-vetdsk48 292 52 use use NN cord-295206-vetdsk48 292 53 for for IN cord-295206-vetdsk48 292 54 treatment treatment NN cord-295206-vetdsk48 292 55 of of IN cord-295206-vetdsk48 292 56 uncomplicated uncomplicated JJ cord-295206-vetdsk48 292 57 acute acute JJ cord-295206-vetdsk48 292 58 bronchitis bronchitis NN cord-295206-vetdsk48 292 59 : : : cord-295206-vetdsk48 292 60 background background NN cord-295206-vetdsk48 292 61 Uncomplicated uncomplicated JJ cord-295206-vetdsk48 292 62 acute acute JJ cord-295206-vetdsk48 292 63 bronchitis bronchitis NN cord-295206-vetdsk48 293 1 Do do VBP cord-295206-vetdsk48 293 2 bacteria bacteria NNS cord-295206-vetdsk48 293 3 cause cause VB cord-295206-vetdsk48 293 4 exacerbations exacerbation NNS cord-295206-vetdsk48 293 5 of of IN cord-295206-vetdsk48 293 6 COPD COPD NNP cord-295206-vetdsk48 293 7 Childhood Childhood NNP cord-295206-vetdsk48 293 8 viral viral JJ cord-295206-vetdsk48 293 9 infection infection NN cord-295206-vetdsk48 293 10 and and CC cord-295206-vetdsk48 293 11 the the DT cord-295206-vetdsk48 293 12 pathogenesis pathogenesis NN cord-295206-vetdsk48 293 13 of of IN cord-295206-vetdsk48 293 14 asthma asthma NN cord-295206-vetdsk48 293 15 and and CC cord-295206-vetdsk48 293 16 chronic chronic JJ cord-295206-vetdsk48 293 17 obstructive obstructive JJ cord-295206-vetdsk48 293 18 lung lung NN cord-295206-vetdsk48 293 19 disease disease NN cord-295206-vetdsk48 293 20 Molecular molecular JJ cord-295206-vetdsk48 293 21 pathogenesis pathogenesis NN cord-295206-vetdsk48 293 22 of of IN cord-295206-vetdsk48 293 23 influenza influenza NN cord-295206-vetdsk48 293 24 A a DT cord-295206-vetdsk48 293 25 virus virus NN cord-295206-vetdsk48 293 26 infection infection NN cord-295206-vetdsk48 293 27 and and CC cord-295206-vetdsk48 293 28 virus virus NN cord-295206-vetdsk48 293 29 - - HYPH cord-295206-vetdsk48 293 30 induced induce VBN cord-295206-vetdsk48 293 31 regulation regulation NN cord-295206-vetdsk48 293 32 of of IN cord-295206-vetdsk48 293 33 cytokine cytokine NN cord-295206-vetdsk48 293 34 gene gene NN cord-295206-vetdsk48 293 35 expression expression NN cord-295206-vetdsk48 293 36 5-Lipoxygenase 5-lipoxygenase CD cord-295206-vetdsk48 293 37 for for IN cord-295206-vetdsk48 293 38 the the DT cord-295206-vetdsk48 293 39 treatment treatment NN cord-295206-vetdsk48 293 40 of of IN cord-295206-vetdsk48 293 41 COPD COPD NNP cord-295206-vetdsk48 293 42 Chronic Chronic NNP cord-295206-vetdsk48 293 43 Obstructive obstructive JJ cord-295206-vetdsk48 293 44 Pulmonary Pulmonary NNP cord-295206-vetdsk48 293 45 Disease Disease NNP cord-295206-vetdsk48 293 46 Surveillance Surveillance NNP cord-295206-vetdsk48 293 47 - - HYPH cord-295206-vetdsk48 293 48 United United NNP cord-295206-vetdsk48 293 49 States States NNP cord-295206-vetdsk48 293 50 Management Management NNP cord-295206-vetdsk48 293 51 of of IN cord-295206-vetdsk48 293 52 acute acute JJ cord-295206-vetdsk48 293 53 exacerbations exacerbation NNS cord-295206-vetdsk48 293 54 of of IN cord-295206-vetdsk48 293 55 COPD COPD NNP cord-295206-vetdsk48 293 56 : : : cord-295206-vetdsk48 293 57 a a DT cord-295206-vetdsk48 293 58 summary summary NN cord-295206-vetdsk48 293 59 and and CC cord-295206-vetdsk48 293 60 appraisal appraisal NN cord-295206-vetdsk48 293 61 of of IN cord-295206-vetdsk48 293 62 published publish VBN cord-295206-vetdsk48 293 63 evidence evidence NN cord-295206-vetdsk48 293 64 Animal Animal NNP cord-295206-vetdsk48 293 65 models model NNS cord-295206-vetdsk48 293 66 of of IN cord-295206-vetdsk48 293 67 chronic chronic JJ cord-295206-vetdsk48 293 68 bronchitis bronchitis NN cord-295206-vetdsk48 293 69 and and CC cord-295206-vetdsk48 293 70 their -PRON- PRP$ cord-295206-vetdsk48 293 71 relevance relevance NN cord-295206-vetdsk48 293 72 to to IN cord-295206-vetdsk48 293 73 studies study NNS cord-295206-vetdsk48 293 74 of of IN cord-295206-vetdsk48 293 75 particle particle NN cord-295206-vetdsk48 293 76 - - HYPH cord-295206-vetdsk48 293 77 induced induce VBN cord-295206-vetdsk48 293 78 disease disease NN cord-295206-vetdsk48 293 79 GOLD GOLD NNP cord-295206-vetdsk48 293 80 Scientific Scientific NNP cord-295206-vetdsk48 293 81 committee committee NN cord-295206-vetdsk48 293 82 Global global JJ cord-295206-vetdsk48 293 83 strategy strategy NN cord-295206-vetdsk48 293 84 for for IN cord-295206-vetdsk48 293 85 the the DT cord-295206-vetdsk48 293 86 diagnosis diagnosis NN cord-295206-vetdsk48 293 87 , , , cord-295206-vetdsk48 293 88 management management NN cord-295206-vetdsk48 293 89 , , , cord-295206-vetdsk48 293 90 and and CC cord-295206-vetdsk48 293 91 prevention prevention NN cord-295206-vetdsk48 293 92 of of IN cord-295206-vetdsk48 293 93 chronic chronic JJ cord-295206-vetdsk48 293 94 obstructive obstructive JJ cord-295206-vetdsk48 293 95 pulmonary pulmonary JJ cord-295206-vetdsk48 293 96 disease disease NN cord-295206-vetdsk48 293 97 Cytokines Cytokines NNPS cord-295206-vetdsk48 293 98 in in IN cord-295206-vetdsk48 293 99 the the DT cord-295206-vetdsk48 293 100 pathogenesis pathogenesis NN cord-295206-vetdsk48 293 101 of of IN cord-295206-vetdsk48 293 102 chronic chronic JJ cord-295206-vetdsk48 293 103 obstructive obstructive JJ cord-295206-vetdsk48 293 104 pulmonary pulmonary JJ cord-295206-vetdsk48 293 105 disease disease NN cord-295206-vetdsk48 293 106 Heliox Heliox NNP cord-295206-vetdsk48 293 107 for for IN cord-295206-vetdsk48 293 108 treatment treatment NN cord-295206-vetdsk48 293 109 of of IN cord-295206-vetdsk48 293 110 exacerbations exacerbation NNS cord-295206-vetdsk48 293 111 of of IN cord-295206-vetdsk48 293 112 chronic chronic JJ cord-295206-vetdsk48 293 113 obstructive obstructive JJ cord-295206-vetdsk48 293 114 pulmonary pulmonary JJ cord-295206-vetdsk48 293 115 disease disease NN cord-295206-vetdsk48 293 116 Diet Diet NNP cord-295206-vetdsk48 293 117 and and CC cord-295206-vetdsk48 293 118 obstructive obstructive JJ cord-295206-vetdsk48 293 119 lung lung NN cord-295206-vetdsk48 293 120 diseases disease NNS cord-295206-vetdsk48 294 1 Helicobacter Helicobacter NNP cord-295206-vetdsk48 294 2 pylori pylori NN cord-295206-vetdsk48 294 3 infection infection NN cord-295206-vetdsk48 294 4 and and CC cord-295206-vetdsk48 294 5 respiratory respiratory JJ cord-295206-vetdsk48 294 6 diseases disease NNS cord-295206-vetdsk48 294 7 : : : cord-295206-vetdsk48 294 8 a a DT cord-295206-vetdsk48 294 9 review review NN cord-295206-vetdsk48 295 1 In in IN cord-295206-vetdsk48 295 2 vitro vitro FW cord-295206-vetdsk48 295 3 and and CC cord-295206-vetdsk48 295 4 in in IN cord-295206-vetdsk48 295 5 vivo vivo NNP cord-295206-vetdsk48 295 6 assay assay NN cord-295206-vetdsk48 295 7 systems system NNS cord-295206-vetdsk48 295 8 for for IN cord-295206-vetdsk48 295 9 study study NN cord-295206-vetdsk48 295 10 of of IN cord-295206-vetdsk48 295 11 influenza influenza NN cord-295206-vetdsk48 295 12 virus virus NN cord-295206-vetdsk48 295 13 inhibitors inhibitors VBP cord-295206-vetdsk48 295 14 Beta2-agonists Beta2-agonists NNP cord-295206-vetdsk48 295 15 for for IN cord-295206-vetdsk48 295 16 acute acute JJ cord-295206-vetdsk48 295 17 bronchitis bronchitis NN cord-295206-vetdsk48 295 18 ( ( -LRB- cord-295206-vetdsk48 295 19 Cochrane Cochrane NNP cord-295206-vetdsk48 295 20 Review Review NNP cord-295206-vetdsk48 295 21 ) ) -RRB- cord-295206-vetdsk48 295 22 treatment treatment NN cord-295206-vetdsk48 295 23 for for IN cord-295206-vetdsk48 295 24 acute acute JJ cord-295206-vetdsk48 295 25 bronchitis bronchitis NN cord-295206-vetdsk48 295 26 ? ? . cord-295206-vetdsk48 296 1 A a DT cord-295206-vetdsk48 296 2 metaanalysis metaanalysis NN cord-295206-vetdsk48 296 3 Pathogenesis pathogenesis NN cord-295206-vetdsk48 296 4 and and CC cord-295206-vetdsk48 296 5 pathology pathology NN cord-295206-vetdsk48 296 6 of of IN cord-295206-vetdsk48 296 7 COPD COPD NNP cord-295206-vetdsk48 296 8 Epidemiology Epidemiology NNP cord-295206-vetdsk48 296 9 of of IN cord-295206-vetdsk48 296 10 chronic chronic JJ cord-295206-vetdsk48 296 11 obstructive obstructive JJ cord-295206-vetdsk48 296 12 pulmonary pulmonary JJ cord-295206-vetdsk48 296 13 disease disease NN cord-295206-vetdsk48 296 14 ( ( -LRB- cord-295206-vetdsk48 296 15 COPD COPD NNP cord-295206-vetdsk48 296 16 ) ) -RRB- cord-295206-vetdsk48 296 17 21st 21st JJ cord-295206-vetdsk48 296 18 century century NN cord-295206-vetdsk48 296 19 perspective perspective NN cord-295206-vetdsk48 296 20 on on IN cord-295206-vetdsk48 296 21 chronic chronic JJ cord-295206-vetdsk48 296 22 obstructive obstructive JJ cord-295206-vetdsk48 296 23 pulmonary pulmonary JJ cord-295206-vetdsk48 296 24 disease disease NN cord-295206-vetdsk48 297 1 Novel novel JJ cord-295206-vetdsk48 297 2 mechanistic mechanistic JJ cord-295206-vetdsk48 297 3 targets target NNS cord-295206-vetdsk48 297 4 for for IN cord-295206-vetdsk48 297 5 the the DT cord-295206-vetdsk48 297 6 treatment treatment NN cord-295206-vetdsk48 297 7 of of IN cord-295206-vetdsk48 297 8 sub sub JJ cord-295206-vetdsk48 297 9 - - JJ cord-295206-vetdsk48 297 10 acute acute JJ cord-295206-vetdsk48 297 11 and and CC cord-295206-vetdsk48 297 12 chronic chronic JJ cord-295206-vetdsk48 297 13 bronchitis bronchitis NN cord-295206-vetdsk48 297 14 Resolution resolution NN cord-295206-vetdsk48 297 15 of of IN cord-295206-vetdsk48 297 16 bronchial bronchial JJ cord-295206-vetdsk48 297 17 inflammation inflammation NN cord-295206-vetdsk48 297 18 is be VBZ cord-295206-vetdsk48 297 19 related relate VBN cord-295206-vetdsk48 297 20 to to IN cord-295206-vetdsk48 297 21 bacterial bacterial JJ cord-295206-vetdsk48 297 22 eradication eradication NN cord-295206-vetdsk48 297 23 following follow VBG cord-295206-vetdsk48 297 24 treatment treatment NN cord-295206-vetdsk48 297 25 of of IN cord-295206-vetdsk48 297 26 exacerbations exacerbation NNS cord-295206-vetdsk48 297 27 of of IN cord-295206-vetdsk48 297 28 chronic chronic JJ cord-295206-vetdsk48 297 29 bronchitis bronchitis NN cord-295206-vetdsk48 298 1 The the DT cord-295206-vetdsk48 298 2 role role NN cord-295206-vetdsk48 298 3 of of IN cord-295206-vetdsk48 298 4 infection infection NN cord-295206-vetdsk48 298 5 in in IN cord-295206-vetdsk48 298 6 COPD COPD NNP cord-295206-vetdsk48 298 7 Global Global NNP cord-295206-vetdsk48 298 8 Initiative Initiative NNP cord-295206-vetdsk48 298 9 for for IN cord-295206-vetdsk48 298 10 Chronic Chronic NNP cord-295206-vetdsk48 298 11 Obstructive Obstructive NNP cord-295206-vetdsk48 298 12 Lung Lung NNP cord-295206-vetdsk48 298 13 Disease Disease NNP cord-295206-vetdsk48 298 14 : : : cord-295206-vetdsk48 298 15 Pocket Pocket NNP cord-295206-vetdsk48 298 16 Guide Guide NNP cord-295206-vetdsk48 298 17 to to IN cord-295206-vetdsk48 298 18 COPD COPD NNP cord-295206-vetdsk48 298 19 Diagnosis Diagnosis NNP cord-295206-vetdsk48 298 20 , , , cord-295206-vetdsk48 298 21 Management Management NNP cord-295206-vetdsk48 298 22 , , , cord-295206-vetdsk48 298 23 and and CC cord-295206-vetdsk48 298 24 Prevention Prevention NNP cord-295206-vetdsk48 298 25 Bronchitis Bronchitis NNP cord-295206-vetdsk48 298 26 and and CC cord-295206-vetdsk48 298 27 Acute Acute NNP cord-295206-vetdsk48 298 28 Febrile Febrile NNP cord-295206-vetdsk48 298 29 Tracheobronchitis Tracheobronchitis NNP cord-295206-vetdsk48 298 30 , , , cord-295206-vetdsk48 299 1 Including include VBG cord-295206-vetdsk48 299 2 Exacerbations Exacerbations NNPS cord-295206-vetdsk48 299 3 of of IN cord-295206-vetdsk48 299 4 Chronic Chronic NNP cord-295206-vetdsk48 299 5 Bronchitis bronchitis NN cord-295206-vetdsk48 299 6 Chronic Chronic NNP cord-295206-vetdsk48 299 7 Bronchitis bronchitis NN cord-295206-vetdsk48 299 8 and and CC cord-295206-vetdsk48 299 9 Emphysema Emphysema NNP cord-295206-vetdsk48 299 10 Costs cost NNS cord-295206-vetdsk48 299 11 of of IN cord-295206-vetdsk48 299 12 chronic chronic JJ cord-295206-vetdsk48 299 13 bronchitis bronchitis NN cord-295206-vetdsk48 299 14 and and CC cord-295206-vetdsk48 299 15 COPD COPD NNP cord-295206-vetdsk48 299 16 : : : cord-295206-vetdsk48 299 17 a a DT cord-295206-vetdsk48 299 18 1-year 1-year CD cord-295206-vetdsk48 299 19 follow follow NN cord-295206-vetdsk48 299 20 - - HYPH cord-295206-vetdsk48 299 21 up up NN cord-295206-vetdsk48 299 22 study study NN cord-295206-vetdsk48 299 23 Few few JJ cord-295206-vetdsk48 299 24 smokers smoker NNS cord-295206-vetdsk48 299 25 develop develop VBP cord-295206-vetdsk48 299 26 COP COP NNP cord-295206-vetdsk48 299 27 D. D. NNP cord-295206-vetdsk48 300 1 Why why WRB cord-295206-vetdsk48 300 2 Clinical clinical JJ cord-295206-vetdsk48 300 3 Management Management NNP cord-295206-vetdsk48 300 4 of of IN cord-295206-vetdsk48 300 5 Chronic Chronic NNP cord-295206-vetdsk48 300 6 Obstructive obstructive JJ cord-295206-vetdsk48 300 7 Pulmonary Pulmonary NNP cord-295206-vetdsk48 300 8 Disease Disease NNP cord-295206-vetdsk48 300 9 Pulmonary Pulmonary NNP cord-295206-vetdsk48 300 10 Pathophysiology Pathophysiology NNP cord-295206-vetdsk48 300 11 : : : cord-295206-vetdsk48 301 1 The the DT cord-295206-vetdsk48 301 2 Essentials Essentials NNPS cord-295206-vetdsk48 301 3 Acute acute JJ cord-295206-vetdsk48 301 4 bronchitis bronchitis NN cord-295206-vetdsk48 301 5 is be VBZ cord-295206-vetdsk48 301 6 a a DT cord-295206-vetdsk48 301 7 very very RB cord-295206-vetdsk48 301 8 common common JJ cord-295206-vetdsk48 301 9 respiratory respiratory JJ cord-295206-vetdsk48 301 10 illness illness NN cord-295206-vetdsk48 301 11 . . . cord-295206-vetdsk48 302 1 An an DT cord-295206-vetdsk48 302 2 elevated elevated JJ cord-295206-vetdsk48 302 3 risk risk NN cord-295206-vetdsk48 302 4 for for IN cord-295206-vetdsk48 302 5 the the DT cord-295206-vetdsk48 302 6 development development NN cord-295206-vetdsk48 302 7 of of IN cord-295206-vetdsk48 302 8 acute acute JJ cord-295206-vetdsk48 302 9 bronchitis bronchitis NN cord-295206-vetdsk48 302 10 is be VBZ cord-295206-vetdsk48 302 11 seen see VBN cord-295206-vetdsk48 302 12 among among IN cord-295206-vetdsk48 302 13 the the DT cord-295206-vetdsk48 302 14 very very RB cord-295206-vetdsk48 302 15 young young JJ cord-295206-vetdsk48 302 16 and and CC cord-295206-vetdsk48 302 17 the the DT cord-295206-vetdsk48 302 18 elderly elderly JJ cord-295206-vetdsk48 302 19 , , , cord-295206-vetdsk48 302 20 smokers smoker NNS cord-295206-vetdsk48 302 21 , , ,