id	sid	tid	token	lemma	pos
cord-319163-d1oj15cw	1	1	key	key	JJ
cord-319163-d1oj15cw	1	2	:	:	:
cord-319163-d1oj15cw	1	3	cord-319163-d1oj15cw	cord-319163-d1oj15cw	NNP
cord-319163-d1oj15cw	1	4	authors	author	NNS
cord-319163-d1oj15cw	1	5	:	:	:
cord-319163-d1oj15cw	1	6	Lee	Lee	NNP
cord-319163-d1oj15cw	1	7	,	,	,
cord-319163-d1oj15cw	1	8	Jinju	Jinju	NNP
cord-319163-d1oj15cw	1	9	;	;	:
cord-319163-d1oj15cw	1	10	Kim	Kim	NNP
cord-319163-d1oj15cw	1	11	,	,	,
cord-319163-d1oj15cw	1	12	Hun	Hun	NNP
cord-319163-d1oj15cw	1	13	Sik	Sik	NNP
cord-319163-d1oj15cw	1	14	title	title	NN
cord-319163-d1oj15cw	1	15	:	:	:
cord-319163-d1oj15cw	1	16	The	the	DT
cord-319163-d1oj15cw	1	17	Role	role	NN
cord-319163-d1oj15cw	1	18	of	of	IN
cord-319163-d1oj15cw	1	19	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	1	20	in	in	IN
cord-319163-d1oj15cw	1	21	Eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	1	22	Airway	Airway	NNP
cord-319163-d1oj15cw	1	23	Inflammation	inflammation	NN
cord-319163-d1oj15cw	1	24	date	date	NN
cord-319163-d1oj15cw	1	25	:	:	:
cord-319163-d1oj15cw	1	26	2019	2019	CD
cord-319163-d1oj15cw	1	27	-	-	HYPH
cord-319163-d1oj15cw	1	28	02	02	CD
cord-319163-d1oj15cw	1	29	-	-	HYPH
cord-319163-d1oj15cw	1	30	04	04	CD
cord-319163-d1oj15cw	1	31	journal	journal	NN
cord-319163-d1oj15cw	1	32	:	:	:
cord-319163-d1oj15cw	2	1	Immune	immune	JJ
cord-319163-d1oj15cw	2	2	Netw	Netw	NNP
cord-319163-d1oj15cw	2	3	DOI	doi	NN
cord-319163-d1oj15cw	2	4	:	:	:
cord-319163-d1oj15cw	3	1	10.4110	10.4110	CD
cord-319163-d1oj15cw	3	2	/	/	SYM
cord-319163-d1oj15cw	3	3	in.2019.19.e5	in.2019.19.e5	NNP
cord-319163-d1oj15cw	3	4	sha	sha	NNP
cord-319163-d1oj15cw	3	5	:	:	:
cord-319163-d1oj15cw	4	1	dcd5c4f4081c90fa1c4672cbe00246e62dcc440a	dcd5c4f4081c90fa1c4672cbe00246e62dcc440a	LS
cord-319163-d1oj15cw	4	2	doc_id	doc_id	CD
cord-319163-d1oj15cw	4	3	:	:	:
cord-319163-d1oj15cw	5	1	319163	319163	CD
cord-319163-d1oj15cw	5	2	cord_uid	cord_uid	NNS
cord-319163-d1oj15cw	5	3	:	:	:
cord-319163-d1oj15cw	6	1	d1oj15cw	d1oj15cw	NNP
cord-319163-d1oj15cw	6	2	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	6	3	is	be	VBZ
cord-319163-d1oj15cw	6	4	a	a	DT
cord-319163-d1oj15cw	6	5	homeostatic	homeostatic	JJ
cord-319163-d1oj15cw	6	6	mechanism	mechanism	NN
cord-319163-d1oj15cw	6	7	that	that	WDT
cord-319163-d1oj15cw	6	8	discards	discard	VBZ
cord-319163-d1oj15cw	6	9	not	not	RB
cord-319163-d1oj15cw	6	10	only	only	RB
cord-319163-d1oj15cw	6	11	invading	invade	VBG
cord-319163-d1oj15cw	6	12	pathogens	pathogen	NNS
cord-319163-d1oj15cw	6	13	but	but	CC
cord-319163-d1oj15cw	6	14	also	also	RB
cord-319163-d1oj15cw	6	15	damaged	damage	VBN
cord-319163-d1oj15cw	6	16	organelles	organelle	NNS
cord-319163-d1oj15cw	6	17	and	and	CC
cord-319163-d1oj15cw	6	18	denatured	denature	VBN
cord-319163-d1oj15cw	6	19	proteins	protein	NNS
cord-319163-d1oj15cw	6	20	via	via	IN
cord-319163-d1oj15cw	6	21	lysosomal	lysosomal	JJ
cord-319163-d1oj15cw	6	22	degradation	degradation	NN
cord-319163-d1oj15cw	6	23	.	.	.
cord-319163-d1oj15cw	7	1	Increasing	increase	VBG
cord-319163-d1oj15cw	7	2	evidence	evidence	NN
cord-319163-d1oj15cw	7	3	suggests	suggest	VBZ
cord-319163-d1oj15cw	7	4	a	a	DT
cord-319163-d1oj15cw	7	5	role	role	NN
cord-319163-d1oj15cw	7	6	for	for	IN
cord-319163-d1oj15cw	7	7	autophagy	autophagy	NN
cord-319163-d1oj15cw	7	8	in	in	IN
cord-319163-d1oj15cw	7	9	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	7	10	diseases	disease	NNS
cord-319163-d1oj15cw	7	11	,	,	,
cord-319163-d1oj15cw	7	12	including	include	VBG
cord-319163-d1oj15cw	7	13	infectious	infectious	JJ
cord-319163-d1oj15cw	7	14	diseases	disease	NNS
cord-319163-d1oj15cw	7	15	,	,	,
cord-319163-d1oj15cw	7	16	Crohn	Crohn	NNP
cord-319163-d1oj15cw	7	17	's	's	POS
cord-319163-d1oj15cw	7	18	disease	disease	NN
cord-319163-d1oj15cw	7	19	,	,	,
cord-319163-d1oj15cw	7	20	cystic	cystic	JJ
cord-319163-d1oj15cw	7	21	fibrosis	fibrosis	NN
cord-319163-d1oj15cw	7	22	,	,	,
cord-319163-d1oj15cw	7	23	and	and	CC
cord-319163-d1oj15cw	7	24	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	7	25	hypertension	hypertension	NN
cord-319163-d1oj15cw	7	26	.	.	.
cord-319163-d1oj15cw	8	1	These	these	DT
cord-319163-d1oj15cw	8	2	studies	study	NNS
cord-319163-d1oj15cw	8	3	suggest	suggest	VBP
cord-319163-d1oj15cw	8	4	that	that	IN
cord-319163-d1oj15cw	8	5	modulating	modulate	VBG
cord-319163-d1oj15cw	8	6	autophagy	autophagy	NN
cord-319163-d1oj15cw	8	7	could	could	MD
cord-319163-d1oj15cw	8	8	be	be	VB
cord-319163-d1oj15cw	8	9	a	a	DT
cord-319163-d1oj15cw	8	10	novel	novel	JJ
cord-319163-d1oj15cw	8	11	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	8	12	option	option	NN
cord-319163-d1oj15cw	8	13	for	for	IN
cord-319163-d1oj15cw	8	14	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	8	15	diseases	disease	NNS
cord-319163-d1oj15cw	8	16	.	.	.
cord-319163-d1oj15cw	9	1	Eosinophils	Eosinophils	NNP
cord-319163-d1oj15cw	9	2	are	be	VBP
cord-319163-d1oj15cw	9	3	a	a	DT
cord-319163-d1oj15cw	9	4	major	major	JJ
cord-319163-d1oj15cw	9	5	type	type	NN
cord-319163-d1oj15cw	9	6	of	of	IN
cord-319163-d1oj15cw	9	7	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	9	8	cell	cell	NN
cord-319163-d1oj15cw	9	9	that	that	WDT
cord-319163-d1oj15cw	9	10	aggravates	aggravate	VBZ
cord-319163-d1oj15cw	9	11	airway	airway	JJ
cord-319163-d1oj15cw	9	12	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	9	13	diseases	disease	NNS
cord-319163-d1oj15cw	9	14	,	,	,
cord-319163-d1oj15cw	9	15	particularly	particularly	RB
cord-319163-d1oj15cw	9	16	corticosteroid	corticosteroid	NN
cord-319163-d1oj15cw	9	17	-	-	HYPH
cord-319163-d1oj15cw	9	18	resistant	resistant	JJ
cord-319163-d1oj15cw	9	19	inflammation	inflammation	NN
cord-319163-d1oj15cw	9	20	.	.	.
cord-319163-d1oj15cw	10	1	The	the	DT
cord-319163-d1oj15cw	10	2	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	10	3	count	count	NN
cord-319163-d1oj15cw	10	4	is	be	VBZ
cord-319163-d1oj15cw	10	5	a	a	DT
cord-319163-d1oj15cw	10	6	useful	useful	JJ
cord-319163-d1oj15cw	10	7	tool	tool	NN
cord-319163-d1oj15cw	10	8	for	for	IN
cord-319163-d1oj15cw	10	9	assessing	assess	VBG
cord-319163-d1oj15cw	10	10	which	which	WDT
cord-319163-d1oj15cw	10	11	patients	patient	NNS
cord-319163-d1oj15cw	10	12	may	may	MD
cord-319163-d1oj15cw	10	13	benefit	benefit	VB
cord-319163-d1oj15cw	10	14	from	from	IN
cord-319163-d1oj15cw	10	15	inhaled	inhale	VBN
cord-319163-d1oj15cw	10	16	corticosteroid	corticosteroid	NN
cord-319163-d1oj15cw	10	17	therapy	therapy	NN
cord-319163-d1oj15cw	10	18	.	.	.
cord-319163-d1oj15cw	11	1	Recent	recent	JJ
cord-319163-d1oj15cw	11	2	studies	study	NNS
cord-319163-d1oj15cw	11	3	demonstrate	demonstrate	VBP
cord-319163-d1oj15cw	11	4	that	that	IN
cord-319163-d1oj15cw	11	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	11	6	plays	play	VBZ
cord-319163-d1oj15cw	11	7	a	a	DT
cord-319163-d1oj15cw	11	8	role	role	NN
cord-319163-d1oj15cw	11	9	in	in	IN
cord-319163-d1oj15cw	11	10	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	11	11	airway	airway	JJ
cord-319163-d1oj15cw	11	12	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	11	13	diseases	disease	NNS
cord-319163-d1oj15cw	11	14	by	by	IN
cord-319163-d1oj15cw	11	15	promoting	promote	VBG
cord-319163-d1oj15cw	11	16	airway	airway	NN
cord-319163-d1oj15cw	11	17	remodeling	remodeling	NN
cord-319163-d1oj15cw	11	18	and	and	CC
cord-319163-d1oj15cw	11	19	loss	loss	NN
cord-319163-d1oj15cw	11	20	of	of	IN
cord-319163-d1oj15cw	11	21	function	function	NN
cord-319163-d1oj15cw	11	22	.	.	.
cord-319163-d1oj15cw	12	1	Genetic	genetic	JJ
cord-319163-d1oj15cw	12	2	variant	variant	NN
cord-319163-d1oj15cw	12	3	in	in	IN
cord-319163-d1oj15cw	12	4	the	the	DT
cord-319163-d1oj15cw	12	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	12	6	gene	gene	NN
cord-319163-d1oj15cw	12	7	ATG5	ATG5	NNP
cord-319163-d1oj15cw	12	8	is	be	VBZ
cord-319163-d1oj15cw	12	9	associated	associate	VBN
cord-319163-d1oj15cw	12	10	with	with	IN
cord-319163-d1oj15cw	12	11	asthma	asthma	NN
cord-319163-d1oj15cw	12	12	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	12	13	,	,	,
cord-319163-d1oj15cw	12	14	and	and	CC
cord-319163-d1oj15cw	12	15	autophagy	autophagy	NN
cord-319163-d1oj15cw	12	16	regulates	regulate	VBZ
cord-319163-d1oj15cw	12	17	apoptotic	apoptotic	JJ
cord-319163-d1oj15cw	12	18	pathways	pathway	NNS
cord-319163-d1oj15cw	12	19	in	in	IN
cord-319163-d1oj15cw	12	20	epithelial	epithelial	JJ
cord-319163-d1oj15cw	12	21	cells	cell	NNS
cord-319163-d1oj15cw	12	22	in	in	IN
cord-319163-d1oj15cw	12	23	individuals	individual	NNS
cord-319163-d1oj15cw	12	24	with	with	IN
cord-319163-d1oj15cw	12	25	chronic	chronic	JJ
cord-319163-d1oj15cw	12	26	obstructive	obstructive	JJ
cord-319163-d1oj15cw	12	27	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	12	28	disease	disease	NN
cord-319163-d1oj15cw	12	29	.	.	.
cord-319163-d1oj15cw	13	1	Moreover	moreover	RB
cord-319163-d1oj15cw	13	2	,	,	,
cord-319163-d1oj15cw	13	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	13	4	dysfunction	dysfunction	NN
cord-319163-d1oj15cw	13	5	leads	lead	VBZ
cord-319163-d1oj15cw	13	6	to	to	IN
cord-319163-d1oj15cw	13	7	severe	severe	JJ
cord-319163-d1oj15cw	13	8	inflammation	inflammation	NN
cord-319163-d1oj15cw	13	9	,	,	,
cord-319163-d1oj15cw	13	10	especially	especially	RB
cord-319163-d1oj15cw	13	11	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	13	12	inflammation	inflammation	NN
cord-319163-d1oj15cw	13	13	,	,	,
cord-319163-d1oj15cw	13	14	in	in	IN
cord-319163-d1oj15cw	13	15	chronic	chronic	JJ
cord-319163-d1oj15cw	13	16	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	13	17	.	.	.
cord-319163-d1oj15cw	14	1	However	however	RB
cord-319163-d1oj15cw	14	2	,	,	,
cord-319163-d1oj15cw	14	3	the	the	DT
cord-319163-d1oj15cw	14	4	mechanism	mechanism	NN
cord-319163-d1oj15cw	14	5	underlying	underlie	VBG
cord-319163-d1oj15cw	14	6	autophagy	autophagy	NN
cord-319163-d1oj15cw	14	7	-	-	HYPH
cord-319163-d1oj15cw	14	8	mediated	mediate	VBN
cord-319163-d1oj15cw	14	9	regulation	regulation	NN
cord-319163-d1oj15cw	14	10	of	of	IN
cord-319163-d1oj15cw	14	11	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	14	12	airway	airway	NN
cord-319163-d1oj15cw	14	13	inflammation	inflammation	NN
cord-319163-d1oj15cw	14	14	remains	remain	VBZ
cord-319163-d1oj15cw	14	15	unclear	unclear	JJ
cord-319163-d1oj15cw	14	16	.	.	.
cord-319163-d1oj15cw	15	1	The	the	DT
cord-319163-d1oj15cw	15	2	aim	aim	NN
cord-319163-d1oj15cw	15	3	of	of	IN
cord-319163-d1oj15cw	15	4	this	this	DT
cord-319163-d1oj15cw	15	5	review	review	NN
cord-319163-d1oj15cw	15	6	is	be	VBZ
cord-319163-d1oj15cw	15	7	to	to	TO
cord-319163-d1oj15cw	15	8	provide	provide	VB
cord-319163-d1oj15cw	15	9	a	a	DT
cord-319163-d1oj15cw	15	10	general	general	JJ
cord-319163-d1oj15cw	15	11	overview	overview	NN
cord-319163-d1oj15cw	15	12	of	of	IN
cord-319163-d1oj15cw	15	13	the	the	DT
cord-319163-d1oj15cw	15	14	role	role	NN
cord-319163-d1oj15cw	15	15	of	of	IN
cord-319163-d1oj15cw	15	16	autophagy	autophagy	NN
cord-319163-d1oj15cw	15	17	in	in	IN
cord-319163-d1oj15cw	15	18	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	15	19	airway	airway	NN
cord-319163-d1oj15cw	15	20	inflammation	inflammation	NN
cord-319163-d1oj15cw	15	21	.	.	.
cord-319163-d1oj15cw	16	1	We	-PRON-	PRP
cord-319163-d1oj15cw	16	2	also	also	RB
cord-319163-d1oj15cw	16	3	suggest	suggest	VBP
cord-319163-d1oj15cw	16	4	that	that	IN
cord-319163-d1oj15cw	16	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	16	6	may	may	MD
cord-319163-d1oj15cw	16	7	be	be	VB
cord-319163-d1oj15cw	16	8	a	a	DT
cord-319163-d1oj15cw	16	9	new	new	JJ
cord-319163-d1oj15cw	16	10	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	16	11	target	target	NN
cord-319163-d1oj15cw	16	12	for	for	IN
cord-319163-d1oj15cw	16	13	airway	airway	NN
cord-319163-d1oj15cw	16	14	inflammation	inflammation	NN
cord-319163-d1oj15cw	16	15	,	,	,
cord-319163-d1oj15cw	16	16	including	include	VBG
cord-319163-d1oj15cw	16	17	that	that	IN
cord-319163-d1oj15cw	16	18	mediated	mediate	VBN
cord-319163-d1oj15cw	16	19	by	by	IN
cord-319163-d1oj15cw	16	20	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	16	21	.	.	.
cord-319163-d1oj15cw	17	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	17	2	is	be	VBZ
cord-319163-d1oj15cw	17	3	an	an	DT
cord-319163-d1oj15cw	17	4	essential	essential	JJ
cord-319163-d1oj15cw	17	5	process	process	NN
cord-319163-d1oj15cw	17	6	that	that	WDT
cord-319163-d1oj15cw	17	7	maintains	maintain	VBZ
cord-319163-d1oj15cw	17	8	cellular	cellular	JJ
cord-319163-d1oj15cw	17	9	homeostasis	homeostasis	NN
cord-319163-d1oj15cw	17	10	and	and	CC
cord-319163-d1oj15cw	17	11	cell	cell	NN
cord-319163-d1oj15cw	17	12	function	function	NN
cord-319163-d1oj15cw	17	13	by	by	IN
cord-319163-d1oj15cw	17	14	delivering	deliver	VBG
cord-319163-d1oj15cw	17	15	cytosolic	cytosolic	JJ
cord-319163-d1oj15cw	17	16	constituents	constituent	NNS
cord-319163-d1oj15cw	17	17	,	,	,
cord-319163-d1oj15cw	17	18	including	include	VBG
cord-319163-d1oj15cw	17	19	organelles	organelle	NNS
cord-319163-d1oj15cw	17	20	,	,	,
cord-319163-d1oj15cw	17	21	denatured	denature	VBN
cord-319163-d1oj15cw	17	22	proteins	protein	NNS
cord-319163-d1oj15cw	17	23	,	,	,
cord-319163-d1oj15cw	17	24	or	or	CC
cord-319163-d1oj15cw	17	25	invading	invade	VBG
cord-319163-d1oj15cw	17	26	pathogens	pathogen	NNS
cord-319163-d1oj15cw	17	27	,	,	,
cord-319163-d1oj15cw	17	28	to	to	IN
cord-319163-d1oj15cw	17	29	lysosomes	lysosome	NNS
cord-319163-d1oj15cw	17	30	for	for	IN
cord-319163-d1oj15cw	17	31	degradation	degradation	NN
cord-319163-d1oj15cw	17	32	and	and	CC
cord-319163-d1oj15cw	17	33	amino	amino	NN
cord-319163-d1oj15cw	17	34	acid	acid	NN
cord-319163-d1oj15cw	17	35	recycling	recycling	NN
cord-319163-d1oj15cw	17	36	(	(	-LRB-
cord-319163-d1oj15cw	17	37	1	1	CD
cord-319163-d1oj15cw	17	38	)	)	-RRB-
cord-319163-d1oj15cw	17	39	(	(	-LRB-
cord-319163-d1oj15cw	17	40	2	2	LS
cord-319163-d1oj15cw	17	41	)	)	-RRB-
cord-319163-d1oj15cw	17	42	(	(	-LRB-
cord-319163-d1oj15cw	17	43	3	3	CD
cord-319163-d1oj15cw	17	44	)	)	-RRB-
cord-319163-d1oj15cw	17	45	.	.	.
cord-319163-d1oj15cw	18	1	Through	through	IN
cord-319163-d1oj15cw	18	2	autophagy	autophagy	NN
cord-319163-d1oj15cw	18	3	,	,	,
cord-319163-d1oj15cw	18	4	cells	cell	NNS
cord-319163-d1oj15cw	18	5	eliminate	eliminate	VBP
cord-319163-d1oj15cw	18	6	damaged	damaged	JJ
cord-319163-d1oj15cw	18	7	or	or	CC
cord-319163-d1oj15cw	18	8	harmful	harmful	JJ
cord-319163-d1oj15cw	18	9	components	component	NNS
cord-319163-d1oj15cw	18	10	,	,	,
cord-319163-d1oj15cw	18	11	thereby	thereby	RB
cord-319163-d1oj15cw	18	12	ensuring	ensure	VBG
cord-319163-d1oj15cw	18	13	survival	survival	NN
cord-319163-d1oj15cw	18	14	after	after	IN
cord-319163-d1oj15cw	18	15	exposure	exposure	NN
cord-319163-d1oj15cw	18	16	to	to	IN
cord-319163-d1oj15cw	18	17	stressors	stressor	NNS
cord-319163-d1oj15cw	18	18	such	such	JJ
cord-319163-d1oj15cw	18	19	as	as	IN
cord-319163-d1oj15cw	18	20	hypoxia	hypoxia	NN
cord-319163-d1oj15cw	18	21	,	,	,
cord-319163-d1oj15cw	18	22	ROS	ROS	NNP
cord-319163-d1oj15cw	18	23	,	,	,
cord-319163-d1oj15cw	18	24	DNA	dna	NN
cord-319163-d1oj15cw	18	25	damage	damage	NN
cord-319163-d1oj15cw	18	26	,	,	,
cord-319163-d1oj15cw	18	27	aggregated	aggregate	VBN
cord-319163-d1oj15cw	18	28	proteins	protein	NNS
cord-319163-d1oj15cw	18	29	,	,	,
cord-319163-d1oj15cw	18	30	damaged	damage	VBN
cord-319163-d1oj15cw	18	31	organelles	organelle	NNS
cord-319163-d1oj15cw	18	32	,	,	,
cord-319163-d1oj15cw	18	33	or	or	CC
cord-319163-d1oj15cw	18	34	intracellular	intracellular	JJ
cord-319163-d1oj15cw	18	35	pathogens	pathogen	NNS
cord-319163-d1oj15cw	18	36	(	(	-LRB-
cord-319163-d1oj15cw	18	37	4	4	CD
cord-319163-d1oj15cw	18	38	)	)	-RRB-
cord-319163-d1oj15cw	18	39	.	.	.
cord-319163-d1oj15cw	19	1	Aberrant	aberrant	JJ
cord-319163-d1oj15cw	19	2	regulation	regulation	NN
cord-319163-d1oj15cw	19	3	of	of	IN
cord-319163-d1oj15cw	19	4	autophagy	autophagy	NN
cord-319163-d1oj15cw	19	5	can	can	MD
cord-319163-d1oj15cw	19	6	result	result	VB
cord-319163-d1oj15cw	19	7	in	in	IN
cord-319163-d1oj15cw	19	8	cancer	cancer	NN
cord-319163-d1oj15cw	19	9	(	(	-LRB-
cord-319163-d1oj15cw	19	10	5	5	CD
cord-319163-d1oj15cw	19	11	)	)	-RRB-
cord-319163-d1oj15cw	19	12	,	,	,
cord-319163-d1oj15cw	19	13	neurodegenerative	neurodegenerative	JJ
cord-319163-d1oj15cw	19	14	disease	disease	NN
cord-319163-d1oj15cw	19	15	(	(	-LRB-
cord-319163-d1oj15cw	19	16	6	6	CD
cord-319163-d1oj15cw	19	17	)	)	-RRB-
cord-319163-d1oj15cw	19	18	,	,	,
cord-319163-d1oj15cw	19	19	and	and	CC
cord-319163-d1oj15cw	19	20	myopathies	myopathies	NNP
cord-319163-d1oj15cw	19	21	(	(	-LRB-
cord-319163-d1oj15cw	19	22	7	7	CD
cord-319163-d1oj15cw	19	23	)	)	-RRB-
cord-319163-d1oj15cw	19	24	.	.	.
cord-319163-d1oj15cw	20	1	Generally	generally	RB
cord-319163-d1oj15cw	20	2	,	,	,
cord-319163-d1oj15cw	20	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	20	4	is	be	VBZ
cord-319163-d1oj15cw	20	5	categorized	categorize	VBN
cord-319163-d1oj15cw	20	6	into	into	IN
cord-319163-d1oj15cw	20	7	3	3	CD
cord-319163-d1oj15cw	20	8	different	different	JJ
cord-319163-d1oj15cw	20	9	types	type	NNS
cord-319163-d1oj15cw	20	10	:	:	:
cord-319163-d1oj15cw	20	11	macroautophagy	macroautophagy	NN
cord-319163-d1oj15cw	20	12	,	,	,
cord-319163-d1oj15cw	20	13	chaperone	chaperone	NN
cord-319163-d1oj15cw	20	14	-	-	HYPH
cord-319163-d1oj15cw	20	15	mediated	mediate	VBN
cord-319163-d1oj15cw	20	16	autophagy	autophagy	NN
cord-319163-d1oj15cw	20	17	,	,	,
cord-319163-d1oj15cw	20	18	and	and	CC
cord-319163-d1oj15cw	20	19	microautophagy	microautophagy	NN
cord-319163-d1oj15cw	20	20	(	(	-LRB-
cord-319163-d1oj15cw	20	21	8)	8)	NNP
cord-319163-d1oj15cw	20	22	.	.	.
cord-319163-d1oj15cw	21	1	Usually	usually	RB
cord-319163-d1oj15cw	21	2	,	,	,
cord-319163-d1oj15cw	21	3	macroautophagy	macroautophagy	NNP
cord-319163-d1oj15cw	21	4	is	be	VBZ
cord-319163-d1oj15cw	21	5	regarded	regard	VBN
cord-319163-d1oj15cw	21	6	as	as	IN
cord-319163-d1oj15cw	21	7	"	"	``
cord-319163-d1oj15cw	21	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	21	9	"	"	''
cord-319163-d1oj15cw	21	10	;	;	:
cord-319163-d1oj15cw	21	11	we	-PRON-	PRP
cord-319163-d1oj15cw	21	12	also	also	RB
cord-319163-d1oj15cw	21	13	referred	refer	VBD
cord-319163-d1oj15cw	21	14	it	-PRON-	PRP
cord-319163-d1oj15cw	21	15	as	as	IN
cord-319163-d1oj15cw	21	16	autophagy	autophagy	NN
cord-319163-d1oj15cw	21	17	in	in	IN
cord-319163-d1oj15cw	21	18	this	this	DT
cord-319163-d1oj15cw	21	19	review	review	NN
cord-319163-d1oj15cw	21	20	.	.	.
cord-319163-d1oj15cw	22	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	22	2	is	be	VBZ
cord-319163-d1oj15cw	22	3	a	a	DT
cord-319163-d1oj15cw	22	4	dynamic	dynamic	JJ
cord-319163-d1oj15cw	22	5	process	process	NN
cord-319163-d1oj15cw	22	6	associated	associate	VBN
cord-319163-d1oj15cw	22	7	with	with	IN
cord-319163-d1oj15cw	22	8	the	the	DT
cord-319163-d1oj15cw	22	9	formation	formation	NN
cord-319163-d1oj15cw	22	10	of	of	IN
cord-319163-d1oj15cw	22	11	autophagosomes	autophagosomes	NNP
cord-319163-d1oj15cw	22	12	,	,	,
cord-319163-d1oj15cw	22	13	which	which	WDT
cord-319163-d1oj15cw	22	14	are	be	VBP
cord-319163-d1oj15cw	22	15	double	double	JJ
cord-319163-d1oj15cw	22	16	-	-	HYPH
cord-319163-d1oj15cw	22	17	membrane	membrane	NN
cord-319163-d1oj15cw	22	18	cytoplasmic	cytoplasmic	JJ
cord-319163-d1oj15cw	22	19	vesicles	vesicle	NNS
cord-319163-d1oj15cw	22	20	that	that	WDT
cord-319163-d1oj15cw	22	21	engulf	engulf	VBP
cord-319163-d1oj15cw	22	22	cellular	cellular	JJ
cord-319163-d1oj15cw	22	23	components	component	NNS
cord-319163-d1oj15cw	22	24	.	.	.
cord-319163-d1oj15cw	23	1	The	the	DT
cord-319163-d1oj15cw	23	2	core	core	NN
cord-319163-d1oj15cw	23	3	proteins	protein	NNS
cord-319163-d1oj15cw	23	4	involved	involve	VBN
cord-319163-d1oj15cw	23	5	in	in	IN
cord-319163-d1oj15cw	23	6	autophagosome	autophagosome	JJ
cord-319163-d1oj15cw	23	7	formation	formation	NN
cord-319163-d1oj15cw	23	8	are	be	VBP
cord-319163-d1oj15cw	23	9	autophagy	autophagy	NN
cord-319163-d1oj15cw	23	10	-	-	HYPH
cord-319163-d1oj15cw	23	11	related	relate	VBN
cord-319163-d1oj15cw	23	12	genes	gene	NNS
cord-319163-d1oj15cw	23	13	(	(	-LRB-
cord-319163-d1oj15cw	23	14	ATG	ATG	NNP
cord-319163-d1oj15cw	23	15	)	)	-RRB-
cord-319163-d1oj15cw	23	16	,	,	,
cord-319163-d1oj15cw	23	17	which	which	WDT
cord-319163-d1oj15cw	23	18	comprise	comprise	VBP
cord-319163-d1oj15cw	23	19	4	4	CD
cord-319163-d1oj15cw	23	20	sub	sub	NN
cord-319163-d1oj15cw	23	21	-	-	NNS
cord-319163-d1oj15cw	23	22	groups	group	NNS
cord-319163-d1oj15cw	23	23	:	:	:
cord-319163-d1oj15cw	24	1	1	1	LS
cord-319163-d1oj15cw	24	2	)	)	-RRB-
cord-319163-d1oj15cw	24	3	the	the	DT
cord-319163-d1oj15cw	24	4	ATG1	ATG1	NNP
cord-319163-d1oj15cw	24	5	/	/	SYM
cord-319163-d1oj15cw	24	6	UNC-51-like	unc-51-like	JJ
cord-319163-d1oj15cw	24	7	kinase	kinase	NN
cord-319163-d1oj15cw	24	8	complex	complex	NN
cord-319163-d1oj15cw	24	9	,	,	,
cord-319163-d1oj15cw	24	10	which	which	WDT
cord-319163-d1oj15cw	24	11	regulates	regulate	VBZ
cord-319163-d1oj15cw	24	12	initiation	initiation	NN
cord-319163-d1oj15cw	24	13	of	of	IN
cord-319163-d1oj15cw	24	14	autophagy	autophagy	NN
cord-319163-d1oj15cw	24	15	;	;	:
cord-319163-d1oj15cw	24	16	2	2	LS
cord-319163-d1oj15cw	24	17	)	)	-RRB-
cord-319163-d1oj15cw	24	18	the	the	DT
cord-319163-d1oj15cw	24	19	ubiquitin	ubiquitin	NN
cord-319163-d1oj15cw	24	20	-	-	HYPH
cord-319163-d1oj15cw	24	21	like	like	JJ
cord-319163-d1oj15cw	24	22	protein	protein	NN
cord-319163-d1oj15cw	24	23	(	(	-LRB-
cord-319163-d1oj15cw	24	24	i.e.	i.e.	FW
cord-319163-d1oj15cw	24	25	,	,	,
cord-319163-d1oj15cw	24	26	ATG12	ATG12	NNP
cord-319163-d1oj15cw	24	27	and	and	CC
cord-319163-d1oj15cw	24	28	ATG8	ATG8	NNP
cord-319163-d1oj15cw	24	29	/	/	SYM
cord-319163-d1oj15cw	24	30	microtubule	microtubule	NN
cord-319163-d1oj15cw	24	31	-	-	HYPH
cord-319163-d1oj15cw	24	32	associated	associate	VBN
cord-319163-d1oj15cw	24	33	protein	protein	NN
cord-319163-d1oj15cw	24	34	1	1	CD
cord-319163-d1oj15cw	24	35	light	light	NN
cord-319163-d1oj15cw	24	36	chain	chain	NN
cord-319163-d1oj15cw	24	37	3	3	CD
cord-319163-d1oj15cw	24	38	[	[	-LRB-
cord-319163-d1oj15cw	24	39	LC3	lc3	JJ
cord-319163-d1oj15cw	24	40	]	]	-RRB-
cord-319163-d1oj15cw	24	41	conjugation	conjugation	NN
cord-319163-d1oj15cw	24	42	system	system	NN
cord-319163-d1oj15cw	24	43	)	)	-RRB-
cord-319163-d1oj15cw	24	44	,	,	,
cord-319163-d1oj15cw	24	45	which	which	WDT
cord-319163-d1oj15cw	24	46	assists	assist	VBZ
cord-319163-d1oj15cw	24	47	elongation	elongation	NN
cord-319163-d1oj15cw	24	48	of	of	IN
cord-319163-d1oj15cw	24	49	the	the	DT
cord-319163-d1oj15cw	24	50	autophagic	autophagic	NN
cord-319163-d1oj15cw	24	51	membrane	membrane	NN
cord-319163-d1oj15cw	24	52	;	;	:
cord-319163-d1oj15cw	24	53	3	3	LS
cord-319163-d1oj15cw	24	54	)	)	-RRB-
cord-319163-d1oj15cw	24	55	the	the	DT
cord-319163-d1oj15cw	24	56	class	class	NN
cord-319163-d1oj15cw	24	57	III	III	NNP
cord-319163-d1oj15cw	24	58	PI3K	PI3K	NNP
cord-319163-d1oj15cw	24	59	/	/	SYM
cord-319163-d1oj15cw	24	60	vacuolar	vacuolar	NNP
cord-319163-d1oj15cw	24	61	protein	protein	NN
cord-319163-d1oj15cw	24	62	sorting	sort	VBG
cord-319163-d1oj15cw	24	63	34	34	CD
cord-319163-d1oj15cw	24	64	complex	complex	NN
cord-319163-d1oj15cw	25	1	I	-PRON-	PRP
cord-319163-d1oj15cw	25	2	,	,	,
cord-319163-d1oj15cw	25	3	which	which	WDT
cord-319163-d1oj15cw	25	4	participates	participate	VBZ
cord-319163-d1oj15cw	25	5	in	in	IN
cord-319163-d1oj15cw	25	6	the	the	DT
cord-319163-d1oj15cw	25	7	early	early	JJ
cord-319163-d1oj15cw	25	8	stages	stage	NNS
cord-319163-d1oj15cw	25	9	of	of	IN
cord-319163-d1oj15cw	25	10	autophagosome	autophagosome	JJ
cord-319163-d1oj15cw	25	11	formation	formation	NN
cord-319163-d1oj15cw	25	12	;	;	:
cord-319163-d1oj15cw	25	13	and	and	CC
cord-319163-d1oj15cw	25	14	4	4	CD
cord-319163-d1oj15cw	25	15	)	)	-RRB-
cord-319163-d1oj15cw	25	16	2	2	CD
cord-319163-d1oj15cw	25	17	transmembrane	transmembrane	NN
cord-319163-d1oj15cw	25	18	proteins	protein	NNS
cord-319163-d1oj15cw	25	19	(	(	-LRB-
cord-319163-d1oj15cw	25	20	i.e.	i.e.	FW
cord-319163-d1oj15cw	25	21	,	,	,
cord-319163-d1oj15cw	25	22	ATG9	ATG9	NNP
cord-319163-d1oj15cw	25	23	/	/	SYM
cord-319163-d1oj15cw	25	24	mammalian	mammalian	JJ
cord-319163-d1oj15cw	25	25	Atg9	Atg9	NNP
cord-319163-d1oj15cw	25	26	and	and	CC
cord-319163-d1oj15cw	25	27	vacuole	vacuole	NN
cord-319163-d1oj15cw	25	28	membrane	membrane	NN
cord-319163-d1oj15cw	25	29	protein	protein	NN
cord-319163-d1oj15cw	25	30	1	1	CD
cord-319163-d1oj15cw	25	31	)	)	-RRB-
cord-319163-d1oj15cw	25	32	,	,	,
cord-319163-d1oj15cw	25	33	which	which	WDT
cord-319163-d1oj15cw	25	34	may	may	MD
cord-319163-d1oj15cw	25	35	contribute	contribute	VB
cord-319163-d1oj15cw	25	36	to	to	IN
cord-319163-d1oj15cw	25	37	the	the	DT
cord-319163-d1oj15cw	25	38	delivery	delivery	NN
cord-319163-d1oj15cw	25	39	process	process	NN
cord-319163-d1oj15cw	25	40	via	via	IN
cord-319163-d1oj15cw	25	41	2	2	CD
cord-319163-d1oj15cw	25	42	major	major	JJ
cord-319163-d1oj15cw	25	43	steps	step	NNS
cord-319163-d1oj15cw	25	44	:	:	:
cord-319163-d1oj15cw	25	45	induction	induction	NN
cord-319163-d1oj15cw	25	46	of	of	IN
cord-319163-d1oj15cw	25	47	autophagosomes	autophagosomes	NNP
cord-319163-d1oj15cw	25	48	and	and	CC
cord-319163-d1oj15cw	25	49	fusion	fusion	NN
cord-319163-d1oj15cw	25	50	of	of	IN
cord-319163-d1oj15cw	25	51	autophagosomes	autophagosome	NNS
cord-319163-d1oj15cw	25	52	with	with	IN
cord-319163-d1oj15cw	25	53	lysosomes	lysosome	NNS
cord-319163-d1oj15cw	25	54	(	(	-LRB-
cord-319163-d1oj15cw	25	55	9,10	9,10	CD
cord-319163-d1oj15cw	25	56	)	)	-RRB-
cord-319163-d1oj15cw	25	57	.	.	.
cord-319163-d1oj15cw	26	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	26	2	regulates	regulate	VBZ
cord-319163-d1oj15cw	26	3	immunity	immunity	NN
cord-319163-d1oj15cw	26	4	by	by	IN
cord-319163-d1oj15cw	26	5	eliminating	eliminate	VBG
cord-319163-d1oj15cw	26	6	invading	invade	VBG
cord-319163-d1oj15cw	26	7	pathogens	pathogen	NNS
cord-319163-d1oj15cw	26	8	,	,	,
cord-319163-d1oj15cw	26	9	regulating	regulate	VBG
cord-319163-d1oj15cw	26	10	recognition	recognition	NN
cord-319163-d1oj15cw	26	11	of	of	IN
cord-319163-d1oj15cw	26	12	innate	innate	JJ
cord-319163-d1oj15cw	26	13	pathogens	pathogen	NNS
cord-319163-d1oj15cw	26	14	,	,	,
cord-319163-d1oj15cw	26	15	playing	play	VBG
cord-319163-d1oj15cw	26	16	roles	role	NNS
cord-319163-d1oj15cw	26	17	in	in	IN
cord-319163-d1oj15cw	26	18	Ag	Ag	NNP
cord-319163-d1oj15cw	26	19	presentation	presentation	NN
cord-319163-d1oj15cw	26	20	via	via	IN
cord-319163-d1oj15cw	26	21	MHC	MHC	NNP
cord-319163-d1oj15cw	26	22	class	class	NN
cord-319163-d1oj15cw	26	23	II	II	NNP
cord-319163-d1oj15cw	26	24	molecules	molecule	NNS
cord-319163-d1oj15cw	26	25	,	,	,
cord-319163-d1oj15cw	26	26	and	and	CC
cord-319163-d1oj15cw	26	27	controlling	control	VBG
cord-319163-d1oj15cw	26	28	B	b	NN
cord-319163-d1oj15cw	26	29	-	-	:
cord-319163-d1oj15cw	26	30	and	and	CC
cord-319163-d1oj15cw	26	31	T	t	NN
cord-319163-d1oj15cw	26	32	-	-	HYPH
cord-319163-d1oj15cw	26	33	cell	cell	NN
cord-319163-d1oj15cw	26	34	development	development	NN
cord-319163-d1oj15cw	26	35	(	(	-LRB-
cord-319163-d1oj15cw	26	36	11	11	CD
cord-319163-d1oj15cw	26	37	)	)	-RRB-
cord-319163-d1oj15cw	26	38	.	.	.
cord-319163-d1oj15cw	27	1	T	T	NNP
cord-319163-d1oj15cw	27	2	-	-	HYPH
cord-319163-d1oj15cw	27	3	cells	cell	NNS
cord-319163-d1oj15cw	27	4	lacking	lack	VBG
cord-319163-d1oj15cw	27	5	Atg5	atg5	RB
cord-319163-d1oj15cw	27	6	,	,	,
cord-319163-d1oj15cw	27	7	Atg7	Atg7	NNP
cord-319163-d1oj15cw	27	8	,	,	,
cord-319163-d1oj15cw	27	9	Atg3	Atg3	NNP
cord-319163-d1oj15cw	27	10	,	,	,
cord-319163-d1oj15cw	27	11	or	or	CC
cord-319163-d1oj15cw	27	12	Beclin-1	Beclin-1	NNP
cord-319163-d1oj15cw	27	13	showed	show	VBD
cord-319163-d1oj15cw	27	14	impaired	impaired	JJ
cord-319163-d1oj15cw	27	15	proliferation	proliferation	NN
cord-319163-d1oj15cw	27	16	and	and	CC
cord-319163-d1oj15cw	27	17	increased	increase	VBN
cord-319163-d1oj15cw	27	18	cell	cell	NN
cord-319163-d1oj15cw	27	19	death	death	NN
cord-319163-d1oj15cw	27	20	(	(	-LRB-
cord-319163-d1oj15cw	27	21	12	12	CD
cord-319163-d1oj15cw	27	22	)	)	-RRB-
cord-319163-d1oj15cw	27	23	.	.	.
cord-319163-d1oj15cw	28	1	Furthermore	furthermore	RB
cord-319163-d1oj15cw	28	2	,	,	,
cord-319163-d1oj15cw	28	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	28	4	dysfunction	dysfunction	NN
cord-319163-d1oj15cw	28	5	is	be	VBZ
cord-319163-d1oj15cw	28	6	related	relate	VBN
cord-319163-d1oj15cw	28	7	to	to	IN
cord-319163-d1oj15cw	28	8	various	various	JJ
cord-319163-d1oj15cw	28	9	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	28	10	diseases	disease	NNS
cord-319163-d1oj15cw	28	11	,	,	,
cord-319163-d1oj15cw	28	12	including	include	VBG
cord-319163-d1oj15cw	28	13	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	28	14	bowel	bowel	NN
cord-319163-d1oj15cw	28	15	disease	disease	NN
cord-319163-d1oj15cw	28	16	(	(	-LRB-
cord-319163-d1oj15cw	28	17	13	13	CD
cord-319163-d1oj15cw	28	18	)	)	-RRB-
cord-319163-d1oj15cw	28	19	,	,	,
cord-319163-d1oj15cw	28	20	asthma	asthma	NN
cord-319163-d1oj15cw	28	21	(	(	-LRB-
cord-319163-d1oj15cw	28	22	14	14	CD
cord-319163-d1oj15cw	28	23	)	)	-RRB-
cord-319163-d1oj15cw	28	24	,	,	,
cord-319163-d1oj15cw	28	25	and	and	CC
cord-319163-d1oj15cw	28	26	chronic	chronic	JJ
cord-319163-d1oj15cw	28	27	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	28	28	(	(	-LRB-
cord-319163-d1oj15cw	28	29	CRS	CRS	NNP
cord-319163-d1oj15cw	28	30	)	)	-RRB-
cord-319163-d1oj15cw	28	31	(	(	-LRB-
cord-319163-d1oj15cw	28	32	15	15	CD
cord-319163-d1oj15cw	28	33	-	-	SYM
cord-319163-d1oj15cw	28	34	17	17	CD
cord-319163-d1oj15cw	28	35	)	)	-RRB-
cord-319163-d1oj15cw	28	36	.	.	.
cord-319163-d1oj15cw	29	1	For	for	IN
cord-319163-d1oj15cw	29	2	example	example	NN
cord-319163-d1oj15cw	29	3	,	,	,
cord-319163-d1oj15cw	29	4	formation	formation	NN
cord-319163-d1oj15cw	29	5	of	of	IN
cord-319163-d1oj15cw	29	6	double	double	JJ
cord-319163-d1oj15cw	29	7	-	-	HYPH
cord-319163-d1oj15cw	29	8	membrane	membrane	NN
cord-319163-d1oj15cw	29	9	autophagosomes	autophagosome	NNS
cord-319163-d1oj15cw	29	10	in	in	IN
cord-319163-d1oj15cw	29	11	fibroblasts	fibroblast	NNS
cord-319163-d1oj15cw	29	12	from	from	IN
cord-319163-d1oj15cw	29	13	severe	severe	JJ
cord-319163-d1oj15cw	29	14	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	29	15	patients	patient	NNS
cord-319163-d1oj15cw	29	16	has	have	VBZ
cord-319163-d1oj15cw	29	17	been	be	VBN
cord-319163-d1oj15cw	29	18	observed	observe	VBN
cord-319163-d1oj15cw	29	19	by	by	IN
cord-319163-d1oj15cw	29	20	electron	electron	NN
cord-319163-d1oj15cw	29	21	microscopy	microscopy	NNP
cord-319163-d1oj15cw	29	22	(	(	-LRB-
cord-319163-d1oj15cw	29	23	18	18	CD
cord-319163-d1oj15cw	29	24	,	,	,
cord-319163-d1oj15cw	29	25	19	19	CD
cord-319163-d1oj15cw	29	26	)	)	-RRB-
cord-319163-d1oj15cw	29	27	,	,	,
cord-319163-d1oj15cw	29	28	and	and	CC
cord-319163-d1oj15cw	29	29	genetic	genetic	JJ
cord-319163-d1oj15cw	29	30	variants	variant	NNS
cord-319163-d1oj15cw	29	31	of	of	IN
cord-319163-d1oj15cw	29	32	the	the	DT
cord-319163-d1oj15cw	29	33	autophagy	autophagy	NN
cord-319163-d1oj15cw	29	34	gene	gene	NN
cord-319163-d1oj15cw	29	35	Atg5	Atg5	NNP
cord-319163-d1oj15cw	29	36	are	be	VBP
cord-319163-d1oj15cw	29	37	associated	associate	VBN
cord-319163-d1oj15cw	29	38	with	with	IN
cord-319163-d1oj15cw	29	39	promotion	promotion	NN
cord-319163-d1oj15cw	29	40	of	of	IN
cord-319163-d1oj15cw	29	41	airway	airway	NN
cord-319163-d1oj15cw	29	42	remodeling	remodeling	NN
cord-319163-d1oj15cw	29	43	and	and	CC
cord-319163-d1oj15cw	29	44	loss	loss	NN
cord-319163-d1oj15cw	29	45	of	of	IN
cord-319163-d1oj15cw	29	46	lung	lung	NN
cord-319163-d1oj15cw	29	47	function	function	NN
cord-319163-d1oj15cw	29	48	in	in	IN
cord-319163-d1oj15cw	29	49	childhood	childhood	NN
cord-319163-d1oj15cw	29	50	asthma	asthma	NN
cord-319163-d1oj15cw	29	51	(	(	-LRB-
cord-319163-d1oj15cw	29	52	20	20	CD
cord-319163-d1oj15cw	29	53	)	)	-RRB-
cord-319163-d1oj15cw	29	54	.	.	.
cord-319163-d1oj15cw	30	1	Eosinophils	Eosinophils	NNP
cord-319163-d1oj15cw	30	2	are	be	VBP
cord-319163-d1oj15cw	30	3	a	a	DT
cord-319163-d1oj15cw	30	4	major	major	JJ
cord-319163-d1oj15cw	30	5	type	type	NN
cord-319163-d1oj15cw	30	6	of	of	IN
cord-319163-d1oj15cw	30	7	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	30	8	cell	cell	NN
cord-319163-d1oj15cw	30	9	that	that	WDT
cord-319163-d1oj15cw	30	10	play	play	VBP
cord-319163-d1oj15cw	30	11	an	an	DT
cord-319163-d1oj15cw	30	12	important	important	JJ
cord-319163-d1oj15cw	30	13	role	role	NN
cord-319163-d1oj15cw	30	14	in	in	IN
cord-319163-d1oj15cw	30	15	airway	airway	JJ
cord-319163-d1oj15cw	30	16	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	30	17	diseases	disease	NNS
cord-319163-d1oj15cw	30	18	,	,	,
cord-319163-d1oj15cw	30	19	including	include	VBG
cord-319163-d1oj15cw	30	20	asthma	asthma	NN
cord-319163-d1oj15cw	30	21	(	(	-LRB-
cord-319163-d1oj15cw	30	22	21	21	CD
cord-319163-d1oj15cw	30	23	)	)	-RRB-
cord-319163-d1oj15cw	30	24	(	(	-LRB-
cord-319163-d1oj15cw	30	25	22	22	CD
cord-319163-d1oj15cw	30	26	)	)	-RRB-
cord-319163-d1oj15cw	30	27	(	(	-LRB-
cord-319163-d1oj15cw	30	28	23	23	CD
cord-319163-d1oj15cw	30	29	)	)	-RRB-
cord-319163-d1oj15cw	30	30	.	.	.
cord-319163-d1oj15cw	31	1	Among	among	IN
cord-319163-d1oj15cw	31	2	the	the	DT
cord-319163-d1oj15cw	31	3	many	many	JJ
cord-319163-d1oj15cw	31	4	proinflammatory	proinflammatory	JJ
cord-319163-d1oj15cw	31	5	molecules	molecule	NNS
cord-319163-d1oj15cw	31	6	,	,	,
cord-319163-d1oj15cw	31	7	IL-5	IL-5	NNP
cord-319163-d1oj15cw	31	8	is	be	VBZ
cord-319163-d1oj15cw	31	9	involved	involve	VBN
cord-319163-d1oj15cw	31	10	in	in	IN
cord-319163-d1oj15cw	31	11	eosinophil	eosinophil	RB
cord-319163-d1oj15cw	31	12	-	-	HYPH
cord-319163-d1oj15cw	31	13	mediated	mediate	VBN
cord-319163-d1oj15cw	31	14	inflammation	inflammation	NN
cord-319163-d1oj15cw	31	15	.	.	.
cord-319163-d1oj15cw	32	1	IL-5	IL-5	NNP
cord-319163-d1oj15cw	32	2	promotes	promote	VBZ
cord-319163-d1oj15cw	32	3	the	the	DT
cord-319163-d1oj15cw	32	4	differentiation	differentiation	NN
cord-319163-d1oj15cw	32	5	,	,	,
cord-319163-d1oj15cw	32	6	survival	survival	NN
cord-319163-d1oj15cw	32	7	,	,	,
cord-319163-d1oj15cw	32	8	trafficking	trafficking	NN
cord-319163-d1oj15cw	32	9	,	,	,
cord-319163-d1oj15cw	32	10	activation	activation	NN
cord-319163-d1oj15cw	32	11	,	,	,
cord-319163-d1oj15cw	32	12	and	and	CC
cord-319163-d1oj15cw	32	13	effector	effector	NN
cord-319163-d1oj15cw	32	14	functions	function	NNS
cord-319163-d1oj15cw	32	15	of	of	IN
cord-319163-d1oj15cw	32	16	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	32	17	(	(	-LRB-
cord-319163-d1oj15cw	32	18	22	22	CD
cord-319163-d1oj15cw	32	19	)	)	-RRB-
cord-319163-d1oj15cw	32	20	.	.	.
cord-319163-d1oj15cw	33	1	Migration	migration	NN
cord-319163-d1oj15cw	33	2	of	of	IN
cord-319163-d1oj15cw	33	3	eosinophils	eosinophils	NN
cord-319163-d1oj15cw	33	4	,	,	,
cord-319163-d1oj15cw	33	5	especially	especially	RB
cord-319163-d1oj15cw	33	6	to	to	IN
cord-319163-d1oj15cw	33	7	the	the	DT
cord-319163-d1oj15cw	33	8	lungs	lung	NNS
cord-319163-d1oj15cw	33	9	,	,	,
cord-319163-d1oj15cw	33	10	is	be	VBZ
cord-319163-d1oj15cw	33	11	regulated	regulate	VBN
cord-319163-d1oj15cw	33	12	by	by	IN
cord-319163-d1oj15cw	33	13	chemokines	chemokine	NNS
cord-319163-d1oj15cw	33	14	such	such	JJ
cord-319163-d1oj15cw	33	15	as	as	IN
cord-319163-d1oj15cw	33	16	CCL5	CCL5	NNP
cord-319163-d1oj15cw	33	17	(	(	-LRB-
cord-319163-d1oj15cw	33	18	regulated	regulate	VBN
cord-319163-d1oj15cw	33	19	on	on	IN
cord-319163-d1oj15cw	33	20	activation	activation	NN
cord-319163-d1oj15cw	33	21	,	,	,
cord-319163-d1oj15cw	33	22	normal	normal	JJ
cord-319163-d1oj15cw	33	23	T	T	NNP
cord-319163-d1oj15cw	33	24	cell	cell	NN
cord-319163-d1oj15cw	33	25	expressed	express	VBD
cord-319163-d1oj15cw	33	26	and	and	CC
cord-319163-d1oj15cw	33	27	secreted	secrete	VBN
cord-319163-d1oj15cw	33	28	[	[	-LRB-
cord-319163-d1oj15cw	33	29	RANTES	RANTES	NNP
cord-319163-d1oj15cw	33	30	]	]	-RRB-
cord-319163-d1oj15cw	33	31	)	)	-RRB-
cord-319163-d1oj15cw	33	32	,	,	,
cord-319163-d1oj15cw	33	33	CCL7	CCL7	NNP
cord-319163-d1oj15cw	33	34	(	(	-LRB-
cord-319163-d1oj15cw	33	35	MCP3	MCP3	NNP
cord-319163-d1oj15cw	33	36	)	)	-RRB-
cord-319163-d1oj15cw	33	37	,	,	,
cord-319163-d1oj15cw	33	38	CCL11	CCL11	NNP
cord-319163-d1oj15cw	34	1	(	(	-LRB-
cord-319163-d1oj15cw	34	2	eotaxin	eotaxin	NNP
cord-319163-d1oj15cw	34	3	1	1	CD
cord-319163-d1oj15cw	34	4	)	)	-RRB-
cord-319163-d1oj15cw	34	5	,	,	,
cord-319163-d1oj15cw	34	6	CCL13	CCL13	NNP
cord-319163-d1oj15cw	34	7	(	(	-LRB-
cord-319163-d1oj15cw	34	8	MCP-4	MCP-4	NNP
cord-319163-d1oj15cw	34	9	)	)	-RRB-
cord-319163-d1oj15cw	34	10	,	,	,
cord-319163-d1oj15cw	34	11	CCL15	CCL15	NNP
cord-319163-d1oj15cw	34	12	,	,	,
cord-319163-d1oj15cw	34	13	CCL24	CCL24	NNP
cord-319163-d1oj15cw	34	14	,	,	,
cord-319163-d1oj15cw	34	15	and	and	CC
cord-319163-d1oj15cw	34	16	CCL26	CCL26	NNP
cord-319163-d1oj15cw	34	17	,	,	,
cord-319163-d1oj15cw	34	18	which	which	WDT
cord-319163-d1oj15cw	34	19	bind	bind	VBP
cord-319163-d1oj15cw	34	20	to	to	IN
cord-319163-d1oj15cw	34	21	CCR3	CCR3	NNP
cord-319163-d1oj15cw	34	22	(	(	-LRB-
cord-319163-d1oj15cw	34	23	23	23	CD
cord-319163-d1oj15cw	34	24	,	,	,
cord-319163-d1oj15cw	34	25	24	24	CD
cord-319163-d1oj15cw	34	26	)	)	-RRB-
cord-319163-d1oj15cw	34	27	.	.	.
cord-319163-d1oj15cw	35	1	Eosinophils	Eosinophils	NNP
cord-319163-d1oj15cw	35	2	with	with	IN
cord-319163-d1oj15cw	35	3	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	35	4	lesions	lesion	NNS
cord-319163-d1oj15cw	35	5	in	in	IN
cord-319163-d1oj15cw	35	6	the	the	DT
cord-319163-d1oj15cw	35	7	lungs	lung	NNS
cord-319163-d1oj15cw	35	8	produce	produce	VB
cord-319163-d1oj15cw	35	9	and	and	CC
cord-319163-d1oj15cw	35	10	release	release	VB
cord-319163-d1oj15cw	35	11	a	a	DT
cord-319163-d1oj15cw	35	12	variety	variety	NN
cord-319163-d1oj15cw	35	13	of	of	IN
cord-319163-d1oj15cw	35	14	proinflammatory	proinflammatory	JJ
cord-319163-d1oj15cw	35	15	mediators	mediator	NNS
cord-319163-d1oj15cw	35	16	,	,	,
cord-319163-d1oj15cw	35	17	including	include	VBG
cord-319163-d1oj15cw	35	18	basic	basic	JJ
cord-319163-d1oj15cw	35	19	proteins	protein	NNS
cord-319163-d1oj15cw	35	20	(	(	-LRB-
cord-319163-d1oj15cw	35	21	major	major	JJ
cord-319163-d1oj15cw	35	22	basic	basic	JJ
cord-319163-d1oj15cw	35	23	protein	protein	NN
cord-319163-d1oj15cw	35	24	,	,	,
cord-319163-d1oj15cw	35	25	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	35	26	cationic	cationic	JJ
cord-319163-d1oj15cw	35	27	protein	protein	NN
cord-319163-d1oj15cw	35	28	[	[	-LRB-
cord-319163-d1oj15cw	35	29	ECP	ECP	NNP
cord-319163-d1oj15cw	35	30	]	]	-RRB-
cord-319163-d1oj15cw	35	31	,	,	,
cord-319163-d1oj15cw	35	32	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	35	33	peroxidase	peroxidase	NN
cord-319163-d1oj15cw	35	34	,	,	,
cord-319163-d1oj15cw	35	35	eosinophil	eosinophil	NN
cord-319163-d1oj15cw	35	36	-	-	HYPH
cord-319163-d1oj15cw	35	37	derived	derive	VBN
cord-319163-d1oj15cw	35	38	neurotoxin	neurotoxin	NN
cord-319163-d1oj15cw	35	39	)	)	-RRB-
cord-319163-d1oj15cw	35	40	,	,	,
cord-319163-d1oj15cw	35	41	cytokines	cytokine	NNS
cord-319163-d1oj15cw	35	42	(	(	-LRB-
cord-319163-d1oj15cw	35	43	IL-2	IL-2	NNP
cord-319163-d1oj15cw	35	44	,	,	,
cord-319163-d1oj15cw	35	45	IL-3	IL-3	NNP
cord-319163-d1oj15cw	35	46	,	,	,
cord-319163-d1oj15cw	35	47	IL-4	IL-4	NNP
cord-319163-d1oj15cw	35	48	,	,	,
cord-319163-d1oj15cw	35	49	IL-5	IL-5	NNP
cord-319163-d1oj15cw	35	50	,	,	,
cord-319163-d1oj15cw	35	51	IL-10	IL-10	NNP
cord-319163-d1oj15cw	35	52	,	,	,
cord-319163-d1oj15cw	35	53	IL-12	IL-12	NNP
cord-319163-d1oj15cw	35	54	,	,	,
cord-319163-d1oj15cw	35	55	IL-13	IL-13	NNP
cord-319163-d1oj15cw	35	56	,	,	,
cord-319163-d1oj15cw	35	57	IL-16	IL-16	NNP
cord-319163-d1oj15cw	35	58	,	,	,
cord-319163-d1oj15cw	35	59	and	and	CC
cord-319163-d1oj15cw	35	60	 	 	_SP
cord-319163-d1oj15cw	35	61	IL-25	IL-25	NNP
cord-319163-d1oj15cw	35	62	)	)	-RRB-
cord-319163-d1oj15cw	35	63	,	,	,
cord-319163-d1oj15cw	35	64	chemokines	chemokine	NNS
cord-319163-d1oj15cw	35	65	(	(	-LRB-
cord-319163-d1oj15cw	35	66	CCL5	CCL5	NNP
cord-319163-d1oj15cw	35	67	,	,	,
cord-319163-d1oj15cw	35	68	CCL11	CCL11	NNP
cord-319163-d1oj15cw	35	69	,	,	,
cord-319163-d1oj15cw	35	70	and	and	CC
cord-319163-d1oj15cw	35	71	CCL13	CCL13	NNP
cord-319163-d1oj15cw	35	72	)	)	-RRB-
cord-319163-d1oj15cw	35	73	,	,	,
cord-319163-d1oj15cw	35	74	growth	growth	NN
cord-319163-d1oj15cw	35	75	factors	factor	NNS
cord-319163-d1oj15cw	35	76	(	(	-LRB-
cord-319163-d1oj15cw	35	77	TNF	TNF	NNP
cord-319163-d1oj15cw	35	78	and	and	CC
cord-319163-d1oj15cw	35	79	TGF	TGF	NNP
cord-319163-d1oj15cw	35	80	-	-	HYPH
cord-319163-d1oj15cw	35	81	α	α	NNP
cord-319163-d1oj15cw	35	82	/	/	SYM
cord-319163-d1oj15cw	35	83	β	β	NN
cord-319163-d1oj15cw	35	84	)	)	-RRB-
cord-319163-d1oj15cw	35	85	(	(	-LRB-
cord-319163-d1oj15cw	35	86	23	23	CD
cord-319163-d1oj15cw	35	87	,	,	,
cord-319163-d1oj15cw	35	88	25	25	CD
cord-319163-d1oj15cw	35	89	)	)	-RRB-
cord-319163-d1oj15cw	35	90	.	.	.
cord-319163-d1oj15cw	36	1	These	these	DT
cord-319163-d1oj15cw	36	2	proteins	protein	NNS
cord-319163-d1oj15cw	36	3	contribute	contribute	VBP
cord-319163-d1oj15cw	36	4	to	to	IN
cord-319163-d1oj15cw	36	5	sustained	sustained	JJ
cord-319163-d1oj15cw	36	6	inflammation	inflammation	NN
cord-319163-d1oj15cw	36	7	(	(	-LRB-
cord-319163-d1oj15cw	36	8	26	26	CD
cord-319163-d1oj15cw	36	9	)	)	-RRB-
cord-319163-d1oj15cw	36	10	and	and	CC
cord-319163-d1oj15cw	36	11	tissue	tissue	NN
cord-319163-d1oj15cw	36	12	damage	damage	NN
cord-319163-d1oj15cw	36	13	(	(	-LRB-
cord-319163-d1oj15cw	36	14	23	23	CD
cord-319163-d1oj15cw	36	15	,	,	,
cord-319163-d1oj15cw	36	16	25	25	CD
cord-319163-d1oj15cw	36	17	)	)	-RRB-
cord-319163-d1oj15cw	36	18	.	.	.
cord-319163-d1oj15cw	37	1	For	for	IN
cord-319163-d1oj15cw	37	2	example	example	NN
cord-319163-d1oj15cw	37	3	,	,	,
cord-319163-d1oj15cw	37	4	TGF	TGF	NNP
cord-319163-d1oj15cw	37	5	-	-	HYPH
cord-319163-d1oj15cw	37	6	β	β	NNP
cord-319163-d1oj15cw	37	7	produced	produce	VBN
cord-319163-d1oj15cw	37	8	by	by	IN
cord-319163-d1oj15cw	37	9	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	37	10	in	in	IN
cord-319163-d1oj15cw	37	11	asthma	asthma	NN
cord-319163-d1oj15cw	37	12	patients	patient	NNS
cord-319163-d1oj15cw	37	13	is	be	VBZ
cord-319163-d1oj15cw	37	14	implicated	implicate	VBN
cord-319163-d1oj15cw	37	15	in	in	IN
cord-319163-d1oj15cw	37	16	tissue	tissue	NN
cord-319163-d1oj15cw	37	17	remodeling	remodeling	NN
cord-319163-d1oj15cw	37	18	through	through	IN
cord-319163-d1oj15cw	37	19	fibroblast	fibroblast	NN
cord-319163-d1oj15cw	37	20	proliferation	proliferation	NN
cord-319163-d1oj15cw	37	21	and	and	CC
cord-319163-d1oj15cw	37	22	increased	increase	VBN
cord-319163-d1oj15cw	37	23	production	production	NN
cord-319163-d1oj15cw	37	24	of	of	IN
cord-319163-d1oj15cw	37	25	collagen	collagen	NN
cord-319163-d1oj15cw	37	26	and	and	CC
cord-319163-d1oj15cw	37	27	glycosaminoglycans	glycosaminoglycan	NNS
cord-319163-d1oj15cw	37	28	(	(	-LRB-
cord-319163-d1oj15cw	37	29	27	27	CD
cord-319163-d1oj15cw	37	30	,	,	,
cord-319163-d1oj15cw	37	31	28	28	CD
cord-319163-d1oj15cw	37	32	)	)	-RRB-
cord-319163-d1oj15cw	37	33	.	.	.
cord-319163-d1oj15cw	38	1	Although	although	IN
cord-319163-d1oj15cw	38	2	evidence	evidence	NN
cord-319163-d1oj15cw	38	3	suggests	suggest	VBZ
cord-319163-d1oj15cw	38	4	that	that	IN
cord-319163-d1oj15cw	38	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	38	6	and	and	CC
cord-319163-d1oj15cw	38	7	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	38	8	play	play	VBP
cord-319163-d1oj15cw	38	9	important	important	JJ
cord-319163-d1oj15cw	38	10	roles	role	NNS
cord-319163-d1oj15cw	38	11	in	in	IN
cord-319163-d1oj15cw	38	12	immune	immune	JJ
cord-319163-d1oj15cw	38	13	responses	response	NNS
cord-319163-d1oj15cw	38	14	and	and	CC
cord-319163-d1oj15cw	38	15	airway	airway	NN
cord-319163-d1oj15cw	38	16	inflammation	inflammation	NN
cord-319163-d1oj15cw	38	17	,	,	,
cord-319163-d1oj15cw	38	18	few	few	JJ
cord-319163-d1oj15cw	38	19	studies	study	NNS
cord-319163-d1oj15cw	38	20	have	have	VBP
cord-319163-d1oj15cw	38	21	examined	examine	VBN
cord-319163-d1oj15cw	38	22	the	the	DT
cord-319163-d1oj15cw	38	23	association	association	NN
cord-319163-d1oj15cw	38	24	between	between	IN
cord-319163-d1oj15cw	38	25	autophagy	autophagy	NN
cord-319163-d1oj15cw	38	26	and	and	CC
cord-319163-d1oj15cw	38	27	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	38	28	in	in	IN
cord-319163-d1oj15cw	38	29	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	38	30	diseases	disease	NNS
cord-319163-d1oj15cw	38	31	.	.	.
cord-319163-d1oj15cw	39	1	Here	here	RB
cord-319163-d1oj15cw	39	2	,	,	,
cord-319163-d1oj15cw	39	3	we	-PRON-	PRP
cord-319163-d1oj15cw	39	4	focus	focus	VBP
cord-319163-d1oj15cw	39	5	on	on	IN
cord-319163-d1oj15cw	39	6	the	the	DT
cord-319163-d1oj15cw	39	7	role	role	NN
cord-319163-d1oj15cw	39	8	of	of	IN
cord-319163-d1oj15cw	39	9	autophagy	autophagy	NN
cord-319163-d1oj15cw	39	10	in	in	IN
cord-319163-d1oj15cw	39	11	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	39	12	airway	airway	NN
cord-319163-d1oj15cw	39	13	inflammation	inflammation	NN
cord-319163-d1oj15cw	39	14	,	,	,
cord-319163-d1oj15cw	39	15	and	and	CC
cord-319163-d1oj15cw	39	16	suggest	suggest	VBP
cord-319163-d1oj15cw	39	17	modulation	modulation	NN
cord-319163-d1oj15cw	39	18	of	of	IN
cord-319163-d1oj15cw	39	19	autophagy	autophagy	NN
cord-319163-d1oj15cw	39	20	as	as	IN
cord-319163-d1oj15cw	39	21	a	a	DT
cord-319163-d1oj15cw	39	22	promising	promising	JJ
cord-319163-d1oj15cw	39	23	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	39	24	approach	approach	NN
cord-319163-d1oj15cw	39	25	to	to	TO
cord-319163-d1oj15cw	39	26	treat	treat	VB
cord-319163-d1oj15cw	39	27	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	39	28	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	39	29	diseases	disease	NNS
cord-319163-d1oj15cw	39	30	.	.	.
cord-319163-d1oj15cw	40	1	Asthma	asthma	NN
cord-319163-d1oj15cw	40	2	is	be	VBZ
cord-319163-d1oj15cw	40	3	a	a	DT
cord-319163-d1oj15cw	40	4	chronic	chronic	JJ
cord-319163-d1oj15cw	40	5	airway	airway	NN
cord-319163-d1oj15cw	40	6	disease	disease	NN
cord-319163-d1oj15cw	40	7	characterized	characterize	VBN
cord-319163-d1oj15cw	40	8	by	by	IN
cord-319163-d1oj15cw	40	9	airway	airway	NNP
cord-319163-d1oj15cw	40	10	hyperresponsiveness	hyperresponsiveness	NNP
cord-319163-d1oj15cw	40	11	(	(	-LRB-
cord-319163-d1oj15cw	40	12	AHR	AHR	NNP
cord-319163-d1oj15cw	40	13	)	)	-RRB-
cord-319163-d1oj15cw	40	14	and	and	CC
cord-319163-d1oj15cw	40	15	inflammation	inflammation	NN
cord-319163-d1oj15cw	40	16	caused	cause	VBN
cord-319163-d1oj15cw	40	17	by	by	IN
cord-319163-d1oj15cw	40	18	molecular	molecular	JJ
cord-319163-d1oj15cw	40	19	and	and	CC
cord-319163-d1oj15cw	40	20	cellular	cellular	JJ
cord-319163-d1oj15cw	40	21	responses	response	NNS
cord-319163-d1oj15cw	40	22	(	(	-LRB-
cord-319163-d1oj15cw	40	23	29	29	CD
cord-319163-d1oj15cw	40	24	)	)	-RRB-
cord-319163-d1oj15cw	40	25	.	.	.
cord-319163-d1oj15cw	41	1	Various	various	JJ
cord-319163-d1oj15cw	41	2	types	type	NNS
cord-319163-d1oj15cw	41	3	of	of	IN
cord-319163-d1oj15cw	41	4	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	41	5	cell	cell	NN
cord-319163-d1oj15cw	41	6	are	be	VBP
cord-319163-d1oj15cw	41	7	involved	involve	VBN
cord-319163-d1oj15cw	41	8	in	in	IN
cord-319163-d1oj15cw	41	9	the	the	DT
cord-319163-d1oj15cw	41	10	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	41	11	of	of	IN
cord-319163-d1oj15cw	41	12	asthma	asthma	NN
cord-319163-d1oj15cw	41	13	,	,	,
cord-319163-d1oj15cw	41	14	including	include	VBG
cord-319163-d1oj15cw	41	15	dendritic	dendritic	JJ
cord-319163-d1oj15cw	41	16	cells	cell	NNS
cord-319163-d1oj15cw	41	17	,	,	,
cord-319163-d1oj15cw	41	18	mast	mast	NN
cord-319163-d1oj15cw	41	19	cells	cell	NNS
cord-319163-d1oj15cw	41	20	,	,	,
cord-319163-d1oj15cw	41	21	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	41	22	and	and	CC
cord-319163-d1oj15cw	41	23	lymphocytes	lymphocyte	NNS
cord-319163-d1oj15cw	41	24	(	(	-LRB-
cord-319163-d1oj15cw	41	25	30	30	CD
cord-319163-d1oj15cw	41	26	)	)	-RRB-
cord-319163-d1oj15cw	41	27	.	.	.
cord-319163-d1oj15cw	42	1	Asthma	asthma	NN
cord-319163-d1oj15cw	42	2	is	be	VBZ
cord-319163-d1oj15cw	42	3	typically	typically	RB
cord-319163-d1oj15cw	42	4	associated	associate	VBN
cord-319163-d1oj15cw	42	5	with	with	IN
cord-319163-d1oj15cw	42	6	an	an	DT
cord-319163-d1oj15cw	42	7	imbalance	imbalance	NN
cord-319163-d1oj15cw	42	8	between	between	IN
cord-319163-d1oj15cw	42	9	Th1	th1	NN
cord-319163-d1oj15cw	42	10	and	and	CC
cord-319163-d1oj15cw	42	11	Th2	th2	CD
cord-319163-d1oj15cw	42	12	pathways	pathway	NNS
cord-319163-d1oj15cw	42	13	;	;	:
cord-319163-d1oj15cw	42	14	over	over	RB
cord-319163-d1oj15cw	42	15	-	-	HYPH
cord-319163-d1oj15cw	42	16	driven	drive	VBN
cord-319163-d1oj15cw	42	17	Th2-mediated	Th2-mediated	NNP
cord-319163-d1oj15cw	42	18	inflammation	inflammation	NN
cord-319163-d1oj15cw	42	19	leads	lead	VBZ
cord-319163-d1oj15cw	42	20	to	to	IN
cord-319163-d1oj15cw	42	21	airway	airway	NN
cord-319163-d1oj15cw	42	22	inflammation	inflammation	NN
cord-319163-d1oj15cw	42	23	and	and	CC
cord-319163-d1oj15cw	42	24	asthma	asthma	NN
cord-319163-d1oj15cw	42	25	(	(	-LRB-
cord-319163-d1oj15cw	42	26	31	31	CD
cord-319163-d1oj15cw	42	27	)	)	-RRB-
cord-319163-d1oj15cw	42	28	.	.	.
cord-319163-d1oj15cw	43	1	In	in	IN
cord-319163-d1oj15cw	43	2	such	such	JJ
cord-319163-d1oj15cw	43	3	situation	situation	NN
cord-319163-d1oj15cw	43	4	,	,	,
cord-319163-d1oj15cw	43	5	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	43	6	play	play	VBP
cord-319163-d1oj15cw	43	7	important	important	JJ
cord-319163-d1oj15cw	43	8	roles	role	NNS
cord-319163-d1oj15cw	43	9	in	in	IN
cord-319163-d1oj15cw	43	10	augmenting	augment	VBG
cord-319163-d1oj15cw	43	11	AHR	ahr	NN
cord-319163-d1oj15cw	43	12	,	,	,
cord-319163-d1oj15cw	43	13	mucus	mucus	NN
cord-319163-d1oj15cw	43	14	production	production	NN
cord-319163-d1oj15cw	43	15	,	,	,
cord-319163-d1oj15cw	43	16	and	and	CC
cord-319163-d1oj15cw	43	17	airway	airway	NN
cord-319163-d1oj15cw	43	18	remodeling	remodeling	NN
cord-319163-d1oj15cw	43	19	in	in	IN
cord-319163-d1oj15cw	43	20	allergic	allergic	JJ
cord-319163-d1oj15cw	43	21	asthma	asthma	NN
cord-319163-d1oj15cw	43	22	by	by	IN
cord-319163-d1oj15cw	43	23	producing	produce	VBG
cord-319163-d1oj15cw	43	24	IL-13	IL-13	NNP
cord-319163-d1oj15cw	43	25	and	and	CC
cord-319163-d1oj15cw	43	26	leukotrienes	leukotriene	NNS
cord-319163-d1oj15cw	43	27	from	from	IN
cord-319163-d1oj15cw	43	28	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	43	29	lipid	lipid	NN
cord-319163-d1oj15cw	43	30	bodies	body	NNS
cord-319163-d1oj15cw	43	31	(	(	-LRB-
cord-319163-d1oj15cw	43	32	23	23	CD
cord-319163-d1oj15cw	43	33	,	,	,
cord-319163-d1oj15cw	43	34	32	32	CD
cord-319163-d1oj15cw	43	35	)	)	-RRB-
cord-319163-d1oj15cw	43	36	.	.	.
cord-319163-d1oj15cw	44	1	Blood	blood	NN
cord-319163-d1oj15cw	44	2	eosinophil	eosinophil	NN
cord-319163-d1oj15cw	44	3	counts	count	NNS
cord-319163-d1oj15cw	44	4	correlate	correlate	VBP
cord-319163-d1oj15cw	44	5	with	with	IN
cord-319163-d1oj15cw	44	6	the	the	DT
cord-319163-d1oj15cw	44	7	severity	severity	NN
cord-319163-d1oj15cw	44	8	of	of	IN
cord-319163-d1oj15cw	44	9	allergic	allergic	JJ
cord-319163-d1oj15cw	44	10	asthma	asthma	NN
cord-319163-d1oj15cw	44	11	(	(	-LRB-
cord-319163-d1oj15cw	44	12	33	33	CD
cord-319163-d1oj15cw	44	13	)	)	-RRB-
cord-319163-d1oj15cw	44	14	,	,	,
cord-319163-d1oj15cw	44	15	and	and	CC
cord-319163-d1oj15cw	44	16	electron	electron	NN
cord-319163-d1oj15cw	44	17	microscopy	microscopy	NN
cord-319163-d1oj15cw	44	18	reveals	reveal	VBZ
cord-319163-d1oj15cw	44	19	large	large	JJ
cord-319163-d1oj15cw	44	20	numbers	number	NNS
cord-319163-d1oj15cw	44	21	of	of	IN
cord-319163-d1oj15cw	44	22	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	44	23	in	in	IN
cord-319163-d1oj15cw	44	24	the	the	DT
cord-319163-d1oj15cw	44	25	bronchial	bronchial	JJ
cord-319163-d1oj15cw	44	26	mucosa	mucosa	NN
cord-319163-d1oj15cw	44	27	of	of	IN
cord-319163-d1oj15cw	44	28	patients	patient	NNS
cord-319163-d1oj15cw	44	29	with	with	IN
cord-319163-d1oj15cw	44	30	severe	severe	JJ
cord-319163-d1oj15cw	44	31	allergic	allergic	JJ
cord-319163-d1oj15cw	44	32	asthma	asthma	NN
cord-319163-d1oj15cw	44	33	(	(	-LRB-
cord-319163-d1oj15cw	44	34	32	32	CD
cord-319163-d1oj15cw	44	35	)	)	-RRB-
cord-319163-d1oj15cw	44	36	.	.	.
cord-319163-d1oj15cw	45	1	Accordingly	accordingly	RB
cord-319163-d1oj15cw	45	2	,	,	,
cord-319163-d1oj15cw	45	3	the	the	DT
cord-319163-d1oj15cw	45	4	current	current	JJ
cord-319163-d1oj15cw	45	5	focus	focus	NN
cord-319163-d1oj15cw	45	6	of	of	IN
cord-319163-d1oj15cw	45	7	asthma	asthma	NN
cord-319163-d1oj15cw	45	8	treatment	treatment	NN
cord-319163-d1oj15cw	45	9	is	be	VBZ
cord-319163-d1oj15cw	45	10	the	the	DT
cord-319163-d1oj15cw	45	11	use	use	NN
cord-319163-d1oj15cw	45	12	of	of	IN
cord-319163-d1oj15cw	45	13	anti	anti	JJ
cord-319163-d1oj15cw	45	14	-	-	JJ
cord-319163-d1oj15cw	45	15	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	45	16	drugs	drug	NNS
cord-319163-d1oj15cw	45	17	such	such	JJ
cord-319163-d1oj15cw	45	18	as	as	IN
cord-319163-d1oj15cw	45	19	inhaled	inhale	VBN
cord-319163-d1oj15cw	45	20	corticosteroids	corticosteroid	NNS
cord-319163-d1oj15cw	45	21	.	.	.
cord-319163-d1oj15cw	46	1	However	however	RB
cord-319163-d1oj15cw	46	2	,	,	,
cord-319163-d1oj15cw	46	3	these	these	DT
cord-319163-d1oj15cw	46	4	drugs	drug	NNS
cord-319163-d1oj15cw	46	5	often	often	RB
cord-319163-d1oj15cw	46	6	failed	fail	VBD
cord-319163-d1oj15cw	46	7	to	to	TO
cord-319163-d1oj15cw	46	8	control	control	VB
cord-319163-d1oj15cw	46	9	asthma	asthma	NN
cord-319163-d1oj15cw	46	10	in	in	IN
cord-319163-d1oj15cw	46	11	some	some	DT
cord-319163-d1oj15cw	46	12	patients	patient	NNS
cord-319163-d1oj15cw	46	13	(	(	-LRB-
cord-319163-d1oj15cw	46	14	34	34	CD
cord-319163-d1oj15cw	46	15	)	)	-RRB-
cord-319163-d1oj15cw	46	16	.	.	.
cord-319163-d1oj15cw	47	1	Recent	recent	JJ
cord-319163-d1oj15cw	47	2	studies	study	NNS
cord-319163-d1oj15cw	47	3	suggest	suggest	VBP
cord-319163-d1oj15cw	47	4	that	that	IN
cord-319163-d1oj15cw	47	5	asthma	asthma	NN
cord-319163-d1oj15cw	47	6	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	47	7	is	be	VBZ
cord-319163-d1oj15cw	47	8	largely	largely	RB
cord-319163-d1oj15cw	47	9	heterogeneous	heterogeneous	JJ
cord-319163-d1oj15cw	47	10	and	and	CC
cord-319163-d1oj15cw	47	11	complex	complex	JJ
cord-319163-d1oj15cw	47	12	,	,	,
cord-319163-d1oj15cw	47	13	which	which	WDT
cord-319163-d1oj15cw	47	14	is	be	VBZ
cord-319163-d1oj15cw	47	15	not	not	RB
cord-319163-d1oj15cw	47	16	simply	simply	RB
cord-319163-d1oj15cw	47	17	driven	drive	VBN
cord-319163-d1oj15cw	47	18	by	by	IN
cord-319163-d1oj15cw	47	19	allergenspecific	allergenspecific	NNP
cord-319163-d1oj15cw	47	20	Th2	th2	CD
cord-319163-d1oj15cw	47	21	lymphocytes	lymphocyte	NNS
cord-319163-d1oj15cw	47	22	as	as	IN
cord-319163-d1oj15cw	47	23	expected	expect	VBN
cord-319163-d1oj15cw	47	24	in	in	IN
cord-319163-d1oj15cw	47	25	allergic	allergic	JJ
cord-319163-d1oj15cw	47	26	asthma	asthma	NN
cord-319163-d1oj15cw	47	27	.	.	.
cord-319163-d1oj15cw	48	1	Some	some	DT
cord-319163-d1oj15cw	48	2	patients	patient	NNS
cord-319163-d1oj15cw	48	3	were	be	VBD
cord-319163-d1oj15cw	48	4	characterized	characterize	VBN
cord-319163-d1oj15cw	48	5	by	by	IN
cord-319163-d1oj15cw	48	6	the	the	DT
cord-319163-d1oj15cw	48	7	upregulation	upregulation	NN
cord-319163-d1oj15cw	48	8	of	of	IN
cord-319163-d1oj15cw	48	9	IFN	IFN	NNP
cord-319163-d1oj15cw	48	10	-	-	HYPH
cord-319163-d1oj15cw	48	11	γ	γ	NNP
cord-319163-d1oj15cw	48	12	,	,	,
cord-319163-d1oj15cw	48	13	IL-17	IL-17	NNP
cord-319163-d1oj15cw	48	14	,	,	,
cord-319163-d1oj15cw	48	15	and	and	CC
cord-319163-d1oj15cw	48	16	neutrophils	neutrophil	NNS
cord-319163-d1oj15cw	48	17	in	in	IN
cord-319163-d1oj15cw	48	18	their	-PRON-	PRP$
cord-319163-d1oj15cw	48	19	lungs	lung	NNS
cord-319163-d1oj15cw	48	20	,	,	,
cord-319163-d1oj15cw	48	21	in	in	IN
cord-319163-d1oj15cw	48	22	which	which	WDT
cord-319163-d1oj15cw	48	23	airway	airway	NNP
cord-319163-d1oj15cw	48	24	neutrophilia	neutrophilia	NNP
cord-319163-d1oj15cw	48	25	correlated	correlate	VBD
cord-319163-d1oj15cw	48	26	with	with	IN
cord-319163-d1oj15cw	48	27	asthma	asthma	NN
cord-319163-d1oj15cw	48	28	severity	severity	NN
cord-319163-d1oj15cw	48	29	(	(	-LRB-
cord-319163-d1oj15cw	48	30	35	35	CD
cord-319163-d1oj15cw	48	31	-	-	SYM
cord-319163-d1oj15cw	48	32	38	38	CD
cord-319163-d1oj15cw	48	33	)	)	-RRB-
cord-319163-d1oj15cw	48	34	.	.	.
cord-319163-d1oj15cw	49	1	Furthermore	furthermore	RB
cord-319163-d1oj15cw	49	2	,	,	,
cord-319163-d1oj15cw	49	3	consistent	consistent	JJ
cord-319163-d1oj15cw	49	4	with	with	IN
cord-319163-d1oj15cw	49	5	the	the	DT
cord-319163-d1oj15cw	49	6	role	role	NN
cord-319163-d1oj15cw	49	7	of	of	IN
cord-319163-d1oj15cw	49	8	IL-17	IL-17	NNP
cord-319163-d1oj15cw	49	9	in	in	IN
cord-319163-d1oj15cw	49	10	neutrophil	neutrophil	NN
cord-319163-d1oj15cw	49	11	recruitment	recruitment	NN
cord-319163-d1oj15cw	49	12	,	,	,
cord-319163-d1oj15cw	49	13	Th17	Th17	NNP
cord-319163-d1oj15cw	49	14	cells	cell	NNS
cord-319163-d1oj15cw	49	15	promoted	promote	VBD
cord-319163-d1oj15cw	49	16	neutrophilic	neutrophilic	JJ
cord-319163-d1oj15cw	49	17	inflammation	inflammation	NN
cord-319163-d1oj15cw	49	18	,	,	,
cord-319163-d1oj15cw	49	19	and	and	CC
cord-319163-d1oj15cw	49	20	contributed	contribute	VBD
cord-319163-d1oj15cw	49	21	to	to	IN
cord-319163-d1oj15cw	49	22	the	the	DT
cord-319163-d1oj15cw	49	23	development	development	NN
cord-319163-d1oj15cw	49	24	of	of	IN
cord-319163-d1oj15cw	49	25	AHR	AHR	NNP
cord-319163-d1oj15cw	49	26	in	in	IN
cord-319163-d1oj15cw	49	27	concert	concert	NN
cord-319163-d1oj15cw	49	28	with	with	IN
cord-319163-d1oj15cw	49	29	Th2	th2	CD
cord-319163-d1oj15cw	49	30	cells	cell	NNS
cord-319163-d1oj15cw	49	31	in	in	IN
cord-319163-d1oj15cw	49	32	asthma	asthma	NN
cord-319163-d1oj15cw	49	33	animal	animal	NN
cord-319163-d1oj15cw	49	34	models	model	NNS
cord-319163-d1oj15cw	49	35	(	(	-LRB-
cord-319163-d1oj15cw	49	36	39	39	CD
cord-319163-d1oj15cw	49	37	)	)	-RRB-
cord-319163-d1oj15cw	49	38	.	.	.
cord-319163-d1oj15cw	50	1	Thus	thus	RB
cord-319163-d1oj15cw	50	2	,	,	,
cord-319163-d1oj15cw	50	3	a	a	DT
cord-319163-d1oj15cw	50	4	novel	novel	JJ
cord-319163-d1oj15cw	50	5	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	50	6	target	target	NN
cord-319163-d1oj15cw	50	7	for	for	IN
cord-319163-d1oj15cw	50	8	treating	treat	VBG
cord-319163-d1oj15cw	50	9	diverse	diverse	JJ
cord-319163-d1oj15cw	50	10	types	type	NNS
cord-319163-d1oj15cw	50	11	of	of	IN
cord-319163-d1oj15cw	50	12	asthma	asthma	NN
cord-319163-d1oj15cw	50	13	,	,	,
cord-319163-d1oj15cw	50	14	including	include	VBG
cord-319163-d1oj15cw	50	15	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	50	16	asthma	asthma	NN
cord-319163-d1oj15cw	50	17	,	,	,
cord-319163-d1oj15cw	50	18	is	be	VBZ
cord-319163-d1oj15cw	50	19	needed	need	VBN
cord-319163-d1oj15cw	50	20	.	.	.
cord-319163-d1oj15cw	51	1	Recent	recent	JJ
cord-319163-d1oj15cw	51	2	studies	study	NNS
cord-319163-d1oj15cw	51	3	suggest	suggest	VBP
cord-319163-d1oj15cw	51	4	that	that	IN
cord-319163-d1oj15cw	51	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	51	6	is	be	VBZ
cord-319163-d1oj15cw	51	7	a	a	DT
cord-319163-d1oj15cw	51	8	promising	promising	JJ
cord-319163-d1oj15cw	51	9	candidate	candidate	NN
cord-319163-d1oj15cw	51	10	.	.	.
cord-319163-d1oj15cw	52	1	Poon	Poon	NNP
cord-319163-d1oj15cw	52	2	et	et	NNP
cord-319163-d1oj15cw	52	3	al	al	NNP
cord-319163-d1oj15cw	52	4	.	.	.
cord-319163-d1oj15cw	53	1	(	(	-LRB-
cord-319163-d1oj15cw	53	2	20	20	CD
cord-319163-d1oj15cw	53	3	)	)	-RRB-
cord-319163-d1oj15cw	53	4	showed	show	VBD
cord-319163-d1oj15cw	53	5	that	that	IN
cord-319163-d1oj15cw	53	6	a	a	DT
cord-319163-d1oj15cw	53	7	single	single	JJ
cord-319163-d1oj15cw	53	8	-	-	HYPH
cord-319163-d1oj15cw	53	9	nucleotide	nucleotide	JJ
cord-319163-d1oj15cw	53	10	polymorphism	polymorphism	NN
cord-319163-d1oj15cw	53	11	(	(	-LRB-
cord-319163-d1oj15cw	53	12	SNP	SNP	NNP
cord-319163-d1oj15cw	53	13	)	)	-RRB-
cord-319163-d1oj15cw	54	1	rs12212740	rs12212740	NNP
cord-319163-d1oj15cw	54	2	G	g	NN
cord-319163-d1oj15cw	54	3	>	>	XX
cord-319163-d1oj15cw	55	1	A	a	DT
cord-319163-d1oj15cw	55	2	of	of	IN
cord-319163-d1oj15cw	55	3	Atg5	Atg5	NNP
cord-319163-d1oj15cw	55	4	correlated	correlate	VBN
cord-319163-d1oj15cw	55	5	significantly	significantly	RB
cord-319163-d1oj15cw	55	6	with	with	IN
cord-319163-d1oj15cw	55	7	a	a	DT
cord-319163-d1oj15cw	55	8	reduction	reduction	NN
cord-319163-d1oj15cw	55	9	in	in	IN
cord-319163-d1oj15cw	55	10	pre	pre	JJ
cord-319163-d1oj15cw	55	11	-	-	JJ
cord-319163-d1oj15cw	55	12	bronchodilator	bronchodilator	JJ
cord-319163-d1oj15cw	55	13	forced	force	VBN
cord-319163-d1oj15cw	55	14	expiratory	expiratory	NNP
cord-319163-d1oj15cw	55	15	volume-1	volume-1	NNP
cord-319163-d1oj15cw	55	16	s	s	POS
cord-319163-d1oj15cw	55	17	(	(	-LRB-
cord-319163-d1oj15cw	55	18	FEV1	FEV1	NNP
cord-319163-d1oj15cw	55	19	)	)	-RRB-
cord-319163-d1oj15cw	55	20	in	in	IN
cord-319163-d1oj15cw	55	21	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	55	22	patients	patient	NNS
cord-319163-d1oj15cw	55	23	(	(	-LRB-
cord-319163-d1oj15cw	55	24	Table	table	NN
cord-319163-d1oj15cw	55	25	1	1	CD
cord-319163-d1oj15cw	55	26	)	)	-RRB-
cord-319163-d1oj15cw	55	27	.	.	.
cord-319163-d1oj15cw	56	1	They	-PRON-	PRP
cord-319163-d1oj15cw	56	2	also	also	RB
cord-319163-d1oj15cw	56	3	used	use	VBD
cord-319163-d1oj15cw	56	4	electron	electron	NN
cord-319163-d1oj15cw	56	5	microscopy	microscopy	NN
cord-319163-d1oj15cw	56	6	to	to	TO
cord-319163-d1oj15cw	56	7	show	show	VB
cord-319163-d1oj15cw	56	8	that	that	IN
cord-319163-d1oj15cw	56	9	fibroblasts	fibroblast	NNS
cord-319163-d1oj15cw	56	10	and	and	CC
cord-319163-d1oj15cw	56	11	epithelial	epithelial	JJ
cord-319163-d1oj15cw	56	12	cells	cell	NNS
cord-319163-d1oj15cw	56	13	in	in	IN
cord-319163-d1oj15cw	56	14	bronchial	bronchial	JJ
cord-319163-d1oj15cw	56	15	biopsy	biopsy	NN
cord-319163-d1oj15cw	56	16	tissue	tissue	NN
cord-319163-d1oj15cw	56	17	from	from	IN
cord-319163-d1oj15cw	56	18	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	56	19	patients	patient	NNS
cord-319163-d1oj15cw	56	20	harbored	harbor	VBD
cord-319163-d1oj15cw	56	21	more	more	RBR
cord-319163-d1oj15cw	56	22	double	double	JJ
cord-319163-d1oj15cw	56	23	-	-	HYPH
cord-319163-d1oj15cw	56	24	membrane	membrane	NN
cord-319163-d1oj15cw	56	25	autophagosomes	autophagosome	NNS
cord-319163-d1oj15cw	56	26	than	than	IN
cord-319163-d1oj15cw	56	27	tissue	tissue	NN
cord-319163-d1oj15cw	56	28	from	from	IN
cord-319163-d1oj15cw	56	29	a	a	DT
cord-319163-d1oj15cw	56	30	healthy	healthy	JJ
cord-319163-d1oj15cw	56	31	subject	subject	NN
cord-319163-d1oj15cw	56	32	(	(	-LRB-
cord-319163-d1oj15cw	56	33	20	20	CD
cord-319163-d1oj15cw	56	34	)	)	-RRB-
cord-319163-d1oj15cw	56	35	.	.	.
cord-319163-d1oj15cw	57	1	Martin	Martin	NNP
cord-319163-d1oj15cw	57	2	and	and	CC
cord-319163-d1oj15cw	57	3	colleagues	colleague	NNS
cord-319163-d1oj15cw	57	4	(	(	-LRB-
cord-319163-d1oj15cw	57	5	18	18	CD
cord-319163-d1oj15cw	57	6	)	)	-RRB-
cord-319163-d1oj15cw	57	7	rs510432	rs510432	NNP
cord-319163-d1oj15cw	57	8	)	)	-RRB-
cord-319163-d1oj15cw	57	9	of	of	IN
cord-319163-d1oj15cw	57	10	Atg5	Atg5	NNP
cord-319163-d1oj15cw	57	11	are	be	VBP
cord-319163-d1oj15cw	57	12	associated	associate	VBN
cord-319163-d1oj15cw	57	13	with	with	IN
cord-319163-d1oj15cw	57	14	childhood	childhood	NN
cord-319163-d1oj15cw	57	15	asthma	asthma	NN
cord-319163-d1oj15cw	57	16	(	(	-LRB-
cord-319163-d1oj15cw	57	17	Table	Table	NNP
cord-319163-d1oj15cw	57	18	1	1	CD
cord-319163-d1oj15cw	57	19	)	)	-RRB-
cord-319163-d1oj15cw	57	20	.	.	.
cord-319163-d1oj15cw	58	1	These	these	DT
cord-319163-d1oj15cw	58	2	findings	finding	NNS
cord-319163-d1oj15cw	58	3	were	be	VBD
cord-319163-d1oj15cw	58	4	tested	test	VBN
cord-319163-d1oj15cw	58	5	in	in	IN
cord-319163-d1oj15cw	58	6	a	a	DT
cord-319163-d1oj15cw	58	7	murine	murine	JJ
cord-319163-d1oj15cw	58	8	model	model	NN
cord-319163-d1oj15cw	58	9	of	of	IN
cord-319163-d1oj15cw	58	10	asthma	asthma	NN
cord-319163-d1oj15cw	58	11	(	(	-LRB-
cord-319163-d1oj15cw	58	12	Table	table	NN
cord-319163-d1oj15cw	58	13	1	1	CD
cord-319163-d1oj15cw	58	14	)	)	-RRB-
cord-319163-d1oj15cw	58	15	(	(	-LRB-
cord-319163-d1oj15cw	58	16	40	40	CD
cord-319163-d1oj15cw	58	17	,	,	,
cord-319163-d1oj15cw	58	18	41	41	CD
cord-319163-d1oj15cw	58	19	)	)	-RRB-
cord-319163-d1oj15cw	58	20	.	.	.
cord-319163-d1oj15cw	59	1	Inhibition	inhibition	NN
cord-319163-d1oj15cw	59	2	of	of	IN
cord-319163-d1oj15cw	59	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	59	4	by	by	IN
cord-319163-d1oj15cw	59	5	intraperitoneal	intraperitoneal	JJ
cord-319163-d1oj15cw	59	6	injection	injection	NN
cord-319163-d1oj15cw	59	7	of	of	IN
cord-319163-d1oj15cw	59	8	3-methyladenine	3-methyladenine	CD
cord-319163-d1oj15cw	59	9	(	(	-LRB-
cord-319163-d1oj15cw	59	10	3-MA	3-ma	CD
cord-319163-d1oj15cw	59	11	)	)	-RRB-
cord-319163-d1oj15cw	59	12	and	and	CC
cord-319163-d1oj15cw	59	13	intranasal	intranasal	NN
cord-319163-d1oj15cw	59	14	knockdown	knockdown	NN
cord-319163-d1oj15cw	59	15	of	of	IN
cord-319163-d1oj15cw	59	16	Atg5	Atg5	NNP
cord-319163-d1oj15cw	59	17	led	lead	VBD
cord-319163-d1oj15cw	59	18	to	to	IN
cord-319163-d1oj15cw	59	19	a	a	DT
cord-319163-d1oj15cw	59	20	marked	mark	VBN
cord-319163-d1oj15cw	59	21	improvement	improvement	NN
cord-319163-d1oj15cw	59	22	in	in	IN
cord-319163-d1oj15cw	59	23	AHR	AHR	NNP
cord-319163-d1oj15cw	59	24	,	,	,
cord-319163-d1oj15cw	59	25	the	the	DT
cord-319163-d1oj15cw	59	26	number	number	NN
cord-319163-d1oj15cw	59	27	of	of	IN
cord-319163-d1oj15cw	59	28	infiltrating	infiltrate	VBG
cord-319163-d1oj15cw	59	29	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	59	30	,	,	,
cord-319163-d1oj15cw	59	31	IL-5	IL-5	NNP
cord-319163-d1oj15cw	59	32	levels	level	NNS
cord-319163-d1oj15cw	59	33	in	in	IN
cord-319163-d1oj15cw	59	34	bronchoalveolar	bronchoalveolar	NNP
cord-319163-d1oj15cw	59	35	lavage	lavage	NN
cord-319163-d1oj15cw	59	36	fluid	fluid	NN
cord-319163-d1oj15cw	59	37	,	,	,
cord-319163-d1oj15cw	59	38	and	and	CC
cord-319163-d1oj15cw	59	39	histological	histological	JJ
cord-319163-d1oj15cw	59	40	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	59	41	features	feature	NNS
cord-319163-d1oj15cw	59	42	(	(	-LRB-
cord-319163-d1oj15cw	59	43	40	40	CD
cord-319163-d1oj15cw	59	44	)	)	-RRB-
cord-319163-d1oj15cw	59	45	.	.	.
cord-319163-d1oj15cw	60	1	However	however	RB
cord-319163-d1oj15cw	60	2	,	,	,
cord-319163-d1oj15cw	60	3	Suzuki	Suzuki	NNP
cord-319163-d1oj15cw	60	4	et	et	NNP
cord-319163-d1oj15cw	60	5	al	al	NNP
cord-319163-d1oj15cw	60	6	.	.	.
cord-319163-d1oj15cw	61	1	(	(	-LRB-
cord-319163-d1oj15cw	61	2	41	41	CD
cord-319163-d1oj15cw	61	3	)	)	-RRB-
cord-319163-d1oj15cw	61	4	showed	show	VBD
cord-319163-d1oj15cw	61	5	that	that	IN
cord-319163-d1oj15cw	61	6	deficiency	deficiency	NN
cord-319163-d1oj15cw	61	7	of	of	IN
cord-319163-d1oj15cw	61	8	CD11c	CD11c	NNP
cord-319163-d1oj15cw	61	9	-	-	HYPH
cord-319163-d1oj15cw	61	10	specific	specific	JJ
cord-319163-d1oj15cw	61	11	autophagy	autophagy	NN
cord-319163-d1oj15cw	61	12	promotes	promote	VBZ
cord-319163-d1oj15cw	61	13	neutrophilic	neutrophilic	NNP
cord-319163-d1oj15cw	61	14	airway	airway	NN
cord-319163-d1oj15cw	61	15	inflammation	inflammation	NN
cord-319163-d1oj15cw	61	16	in	in	IN
cord-319163-d1oj15cw	61	17	a	a	DT
cord-319163-d1oj15cw	61	18	murine	murine	JJ
cord-319163-d1oj15cw	61	19	asthma	asthma	NN
cord-319163-d1oj15cw	61	20	model	model	NN
cord-319163-d1oj15cw	61	21	.	.	.
cord-319163-d1oj15cw	62	1	They	-PRON-	PRP
cord-319163-d1oj15cw	62	2	found	find	VBD
cord-319163-d1oj15cw	62	3	that	that	IN
cord-319163-d1oj15cw	62	4	impaired	impaired	JJ
cord-319163-d1oj15cw	62	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	62	6	induced	induce	VBN
cord-319163-d1oj15cw	62	7	Th17	th17	CD
cord-319163-d1oj15cw	62	8	polarization	polarization	NN
cord-319163-d1oj15cw	62	9	,	,	,
cord-319163-d1oj15cw	62	10	resulting	result	VBG
cord-319163-d1oj15cw	62	11	in	in	IN
cord-319163-d1oj15cw	62	12	refractory	refractory	JJ
cord-319163-d1oj15cw	62	13	asthma	asthma	NN
cord-319163-d1oj15cw	62	14	(	(	-LRB-
cord-319163-d1oj15cw	62	15	41	41	CD
cord-319163-d1oj15cw	62	16	)	)	-RRB-
cord-319163-d1oj15cw	62	17	.	.	.
cord-319163-d1oj15cw	63	1	Although	although	IN
cord-319163-d1oj15cw	63	2	they	-PRON-	PRP
cord-319163-d1oj15cw	63	3	demonstrated	demonstrate	VBD
cord-319163-d1oj15cw	63	4	a	a	DT
cord-319163-d1oj15cw	63	5	role	role	NN
cord-319163-d1oj15cw	63	6	for	for	IN
cord-319163-d1oj15cw	63	7	autophagy	autophagy	NN
cord-319163-d1oj15cw	63	8	in	in	IN
cord-319163-d1oj15cw	63	9	neutrophilic	neutrophilic	JJ
cord-319163-d1oj15cw	63	10	airway	airway	NN
cord-319163-d1oj15cw	63	11	inflammation	inflammation	NN
cord-319163-d1oj15cw	63	12	,	,	,
cord-319163-d1oj15cw	63	13	but	but	CC
cord-319163-d1oj15cw	63	14	not	not	RB
cord-319163-d1oj15cw	63	15	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	63	16	inflammation	inflammation	NN
cord-319163-d1oj15cw	63	17	,	,	,
cord-319163-d1oj15cw	63	18	the	the	DT
cord-319163-d1oj15cw	63	19	results	result	NNS
cord-319163-d1oj15cw	63	20	suggest	suggest	VBP
cord-319163-d1oj15cw	63	21	that	that	IN
cord-319163-d1oj15cw	63	22	autophagy	autophagy	NN
cord-319163-d1oj15cw	63	23	plays	play	VBZ
cord-319163-d1oj15cw	63	24	an	an	DT
cord-319163-d1oj15cw	63	25	important	important	JJ
cord-319163-d1oj15cw	63	26	and	and	CC
cord-319163-d1oj15cw	63	27	diverse	diverse	JJ
cord-319163-d1oj15cw	63	28	role	role	NN
cord-319163-d1oj15cw	63	29	in	in	IN
cord-319163-d1oj15cw	63	30	asthma	asthma	NN
cord-319163-d1oj15cw	63	31	.	.	.
cord-319163-d1oj15cw	64	1	In	in	IN
cord-319163-d1oj15cw	64	2	addition	addition	NN
cord-319163-d1oj15cw	64	3	,	,	,
cord-319163-d1oj15cw	64	4	recent	recent	JJ
cord-319163-d1oj15cw	64	5	studies	study	NNS
cord-319163-d1oj15cw	64	6	demonstrated	demonstrate	VBD
cord-319163-d1oj15cw	64	7	that	that	IN
cord-319163-d1oj15cw	64	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	64	9	plays	play	VBZ
cord-319163-d1oj15cw	64	10	a	a	DT
cord-319163-d1oj15cw	64	11	crucial	crucial	JJ
cord-319163-d1oj15cw	64	12	role	role	NN
cord-319163-d1oj15cw	64	13	in	in	IN
cord-319163-d1oj15cw	64	14	airway	airway	NN
cord-319163-d1oj15cw	64	15	remodeling	remodeling	NN
cord-319163-d1oj15cw	64	16	in	in	IN
cord-319163-d1oj15cw	64	17	airway	airway	JJ
cord-319163-d1oj15cw	64	18	smooth	smooth	JJ
cord-319163-d1oj15cw	64	19	muscle	muscle	NN
cord-319163-d1oj15cw	64	20	(	(	-LRB-
cord-319163-d1oj15cw	64	21	ASM	ASM	NNP
cord-319163-d1oj15cw	64	22	)	)	-RRB-
cord-319163-d1oj15cw	64	23	cells	cell	NNS
cord-319163-d1oj15cw	64	24	(	(	-LRB-
cord-319163-d1oj15cw	64	25	Table	table	NN
cord-319163-d1oj15cw	64	26	1	1	CD
cord-319163-d1oj15cw	64	27	)	)	-RRB-
cord-319163-d1oj15cw	64	28	.	.	.
cord-319163-d1oj15cw	65	1	Ghavami	Ghavami	NNP
cord-319163-d1oj15cw	65	2	et	et	FW
cord-319163-d1oj15cw	65	3	al	al	NNP
cord-319163-d1oj15cw	65	4	.	.	.
cord-319163-d1oj15cw	66	1	(	(	-LRB-
cord-319163-d1oj15cw	66	2	42	42	CD
cord-319163-d1oj15cw	66	3	)	)	-RRB-
cord-319163-d1oj15cw	66	4	showed	show	VBD
cord-319163-d1oj15cw	66	5	that	that	IN
cord-319163-d1oj15cw	66	6	autophagy	autophagy	NN
cord-319163-d1oj15cw	66	7	is	be	VBZ
cord-319163-d1oj15cw	66	8	a	a	DT
cord-319163-d1oj15cw	66	9	regulator	regulator	NN
cord-319163-d1oj15cw	66	10	of	of	IN
cord-319163-d1oj15cw	66	11	fibrogenesis	fibrogenesis	NN
cord-319163-d1oj15cw	66	12	induced	induce	VBN
cord-319163-d1oj15cw	66	13	by	by	IN
cord-319163-d1oj15cw	66	14	TGF	TGF	NNP
cord-319163-d1oj15cw	66	15	-	-	HYPH
cord-319163-d1oj15cw	66	16	β1	β1	NNP
cord-319163-d1oj15cw	66	17	in	in	IN
cord-319163-d1oj15cw	66	18	primary	primary	JJ
cord-319163-d1oj15cw	66	19	human	human	JJ
cord-319163-d1oj15cw	66	20	atrial	atrial	JJ
cord-319163-d1oj15cw	66	21	myofibroblasts	myofibroblast	NNS
cord-319163-d1oj15cw	66	22	(	(	-LRB-
cord-319163-d1oj15cw	66	23	hATMyofbs	hATMyofbs	NNP
cord-319163-d1oj15cw	66	24	)	)	-RRB-
cord-319163-d1oj15cw	66	25	.	.	.
cord-319163-d1oj15cw	67	1	TGF	TGF	NNP
cord-319163-d1oj15cw	67	2	-	-	HYPH
cord-319163-d1oj15cw	67	3	β1	β1	NNP
cord-319163-d1oj15cw	67	4	promoted	promote	VBD
cord-319163-d1oj15cw	67	5	collagen-1	collagen-1	NNP
cord-319163-d1oj15cw	67	6	and	and	CC
cord-319163-d1oj15cw	67	7	fibronectin	fibronectin	NN
cord-319163-d1oj15cw	67	8	synthesis	synthesis	NN
cord-319163-d1oj15cw	67	9	in	in	IN
cord-319163-d1oj15cw	67	10	hATMyofbs	hATMyofbs	NNP
cord-319163-d1oj15cw	67	11	,	,	,
cord-319163-d1oj15cw	67	12	which	which	WDT
cord-319163-d1oj15cw	67	13	correlated	correlate	VBD
cord-319163-d1oj15cw	67	14	with	with	IN
cord-319163-d1oj15cw	67	15	autophagic	autophagic	JJ
cord-319163-d1oj15cw	67	16	activation	activation	NN
cord-319163-d1oj15cw	67	17	in	in	IN
cord-319163-d1oj15cw	67	18	these	these	DT
cord-319163-d1oj15cw	67	19	cells	cell	NNS
cord-319163-d1oj15cw	67	20	.	.	.
cord-319163-d1oj15cw	68	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	68	2	inhibition	inhibition	NN
cord-319163-d1oj15cw	68	3	by	by	IN
cord-319163-d1oj15cw	68	4	ATG5	atg5	JJ
cord-319163-d1oj15cw	68	5	deficiency	deficiency	NN
cord-319163-d1oj15cw	68	6	or	or	CC
cord-319163-d1oj15cw	68	7	treatment	treatment	NN
cord-319163-d1oj15cw	68	8	with	with	IN
cord-319163-d1oj15cw	68	9	bafilomycin	bafilomycin	NNS
cord-319163-d1oj15cw	68	10	-	-	HYPH
cord-319163-d1oj15cw	68	11	A1	A1	NNP
cord-319163-d1oj15cw	68	12	(	(	-LRB-
cord-319163-d1oj15cw	68	13	Baf	Baf	NNP
cord-319163-d1oj15cw	68	14	-	-	HYPH
cord-319163-d1oj15cw	68	15	A1	A1	NNP
cord-319163-d1oj15cw	68	16	)	)	-RRB-
cord-319163-d1oj15cw	68	17	and	and	CC
cord-319163-d1oj15cw	68	18	3-MA	3-ma	CD
cord-319163-d1oj15cw	68	19	decreased	decrease	VBD
cord-319163-d1oj15cw	68	20	the	the	DT
cord-319163-d1oj15cw	68	21	fibrotic	fibrotic	JJ
cord-319163-d1oj15cw	68	22	effect	effect	NN
cord-319163-d1oj15cw	68	23	of	of	IN
cord-319163-d1oj15cw	68	24	TGF	TGF	NNP
cord-319163-d1oj15cw	68	25	-	-	HYPH
cord-319163-d1oj15cw	68	26	β1	β1	NNP
cord-319163-d1oj15cw	68	27	(	(	-LRB-
cord-319163-d1oj15cw	68	28	42	42	CD
cord-319163-d1oj15cw	68	29	)	)	-RRB-
cord-319163-d1oj15cw	68	30	.	.	.
cord-319163-d1oj15cw	69	1	McAlinden	McAlinden	NNP
cord-319163-d1oj15cw	69	2	et	et	NNP
cord-319163-d1oj15cw	69	3	al	al	NNP
cord-319163-d1oj15cw	69	4	.	.	.
cord-319163-d1oj15cw	70	1	(	(	-LRB-
cord-319163-d1oj15cw	70	2	43	43	CD
cord-319163-d1oj15cw	70	3	)	)	-RRB-
cord-319163-d1oj15cw	70	4	investigated	investigate	VBD
cord-319163-d1oj15cw	70	5	the	the	DT
cord-319163-d1oj15cw	70	6	correlation	correlation	NN
cord-319163-d1oj15cw	70	7	between	between	IN
cord-319163-d1oj15cw	70	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	70	9	activation	activation	NN
cord-319163-d1oj15cw	70	10	and	and	CC
cord-319163-d1oj15cw	70	11	asthma	asthma	NN
cord-319163-d1oj15cw	70	12	airway	airway	NN
cord-319163-d1oj15cw	70	13	remodeling	remodeling	NN
cord-319163-d1oj15cw	70	14	;	;	,
cord-319163-d1oj15cw	70	15	human	human	JJ
cord-319163-d1oj15cw	70	16	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	70	17	tissues	tissue	NNS
cord-319163-d1oj15cw	70	18	showed	show	VBD
cord-319163-d1oj15cw	70	19	thickened	thickened	JJ
cord-319163-d1oj15cw	70	20	epithelium	epithelium	NN
cord-319163-d1oj15cw	70	21	,	,	,
cord-319163-d1oj15cw	70	22	greater	great	JJR
cord-319163-d1oj15cw	70	23	lamina	lamina	NN
cord-319163-d1oj15cw	70	24	propria	propria	NN
cord-319163-d1oj15cw	70	25	depth	depth	NN
cord-319163-d1oj15cw	70	26	,	,	,
cord-319163-d1oj15cw	70	27	and	and	CC
cord-319163-d1oj15cw	70	28	increase	increase	VB
cord-319163-d1oj15cw	70	29	in	in	IN
cord-319163-d1oj15cw	70	30	ASM	asm	JJ
cord-319163-d1oj15cw	70	31	bundles	bundle	NNS
cord-319163-d1oj15cw	70	32	with	with	IN
cord-319163-d1oj15cw	70	33	higher	high	JJR
cord-319163-d1oj15cw	70	34	expression	expression	NN
cord-319163-d1oj15cw	70	35	of	of	IN
cord-319163-d1oj15cw	70	36	Beclin1	Beclin1	NNP
cord-319163-d1oj15cw	70	37	and	and	CC
cord-319163-d1oj15cw	70	38	ATG5	ATG5	NNP
cord-319163-d1oj15cw	70	39	along	along	IN
cord-319163-d1oj15cw	70	40	with	with	IN
cord-319163-d1oj15cw	70	41	reduced	reduce	VBN
cord-319163-d1oj15cw	70	42	p62	p62	NN
cord-319163-d1oj15cw	70	43	compared	compare	VBN
cord-319163-d1oj15cw	70	44	with	with	IN
cord-319163-d1oj15cw	70	45	non	non	JJ
cord-319163-d1oj15cw	70	46	-	-	JJ
cord-319163-d1oj15cw	70	47	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	70	48	controls	control	NNS
cord-319163-d1oj15cw	70	49	.	.	.
cord-319163-d1oj15cw	71	1	They	-PRON-	PRP
cord-319163-d1oj15cw	71	2	also	also	RB
cord-319163-d1oj15cw	71	3	showed	show	VBD
cord-319163-d1oj15cw	71	4	that	that	IN
cord-319163-d1oj15cw	71	5	TGF	TGF	NNP
cord-319163-d1oj15cw	71	6	-	-	HYPH
cord-319163-d1oj15cw	71	7	β1	β1	NNP
cord-319163-d1oj15cw	71	8	induces	induce	VBZ
cord-319163-d1oj15cw	71	9	upregulation	upregulation	NN
cord-319163-d1oj15cw	71	10	of	of	IN
cord-319163-d1oj15cw	71	11	airway	airway	NN
cord-319163-d1oj15cw	71	12	remodeling	remodeling	NN
cord-319163-d1oj15cw	71	13	markers	marker	NNS
cord-319163-d1oj15cw	71	14	,	,	,
cord-319163-d1oj15cw	71	15	collagen-1	collagen-1	NNP
cord-319163-d1oj15cw	71	16	and	and	CC
cord-319163-d1oj15cw	71	17	SMAD2/3	SMAD2/3	NNP
cord-319163-d1oj15cw	71	18	phosphorylation	phosphorylation	NN
cord-319163-d1oj15cw	71	19	(	(	-LRB-
cord-319163-d1oj15cw	71	20	pro	pro	JJ
cord-319163-d1oj15cw	71	21	-	-	JJ
cord-319163-d1oj15cw	71	22	fibrotic	fibrotic	JJ
cord-319163-d1oj15cw	71	23	signaling	signaling	NN
cord-319163-d1oj15cw	71	24	)	)	-RRB-
cord-319163-d1oj15cw	71	25	along	along	IN
cord-319163-d1oj15cw	71	26	with	with	IN
cord-319163-d1oj15cw	71	27	the	the	DT
cord-319163-d1oj15cw	71	28	increased	increase	VBN
cord-319163-d1oj15cw	71	29	expression	expression	NN
cord-319163-d1oj15cw	71	30	of	of	IN
cord-319163-d1oj15cw	71	31	Beclin-1	Beclin-1	NNP
cord-319163-d1oj15cw	71	32	and	and	CC
cord-319163-d1oj15cw	71	33	LC3B	LC3B	NNP
cord-319163-d1oj15cw	71	34	-	-	HYPH
cord-319163-d1oj15cw	71	35	II	II	NNP
cord-319163-d1oj15cw	71	36	(	(	-LRB-
cord-319163-d1oj15cw	71	37	a	a	DT
cord-319163-d1oj15cw	71	38	marker	marker	NN
cord-319163-d1oj15cw	71	39	of	of	IN
cord-319163-d1oj15cw	71	40	autophagosome	autophagosome	JJ
cord-319163-d1oj15cw	71	41	formation	formation	NN
cord-319163-d1oj15cw	71	42	)	)	-RRB-
cord-319163-d1oj15cw	71	43	in	in	IN
cord-319163-d1oj15cw	71	44	ASM	asm	JJ
cord-319163-d1oj15cw	71	45	cells	cell	NNS
cord-319163-d1oj15cw	71	46	,	,	,
cord-319163-d1oj15cw	71	47	which	which	WDT
cord-319163-d1oj15cw	71	48	was	be	VBD
cord-319163-d1oj15cw	71	49	reversed	reverse	VBN
cord-319163-d1oj15cw	71	50	by	by	IN
cord-319163-d1oj15cw	71	51	an	an	DT
cord-319163-d1oj15cw	71	52	autophagy	autophagy	NN
cord-319163-d1oj15cw	71	53	inhibitor	inhibitor	NN
cord-319163-d1oj15cw	71	54	,	,	,
cord-319163-d1oj15cw	71	55	chloroquine	chloroquine	NN
cord-319163-d1oj15cw	71	56	(	(	-LRB-
cord-319163-d1oj15cw	71	57	CQ	CQ	NNP
cord-319163-d1oj15cw	71	58	)	)	-RRB-
cord-319163-d1oj15cw	71	59	.	.	.
cord-319163-d1oj15cw	72	1	CQ	CQ	NNP
cord-319163-d1oj15cw	72	2	also	also	RB
cord-319163-d1oj15cw	72	3	prevented	prevent	VBD
cord-319163-d1oj15cw	72	4	accumulation	accumulation	NN
cord-319163-d1oj15cw	72	5	of	of	IN
cord-319163-d1oj15cw	72	6	collagen	collagen	NN
cord-319163-d1oj15cw	72	7	in	in	IN
cord-319163-d1oj15cw	72	8	the	the	DT
cord-319163-d1oj15cw	72	9	lung	lung	NN
cord-319163-d1oj15cw	72	10	of	of	IN
cord-319163-d1oj15cw	72	11	murine	murine	JJ
cord-319163-d1oj15cw	72	12	asthma	asthma	NN
cord-319163-d1oj15cw	72	13	models	model	NNS
cord-319163-d1oj15cw	72	14	(	(	-LRB-
cord-319163-d1oj15cw	72	15	43	43	CD
cord-319163-d1oj15cw	72	16	)	)	-RRB-
cord-319163-d1oj15cw	72	17	.	.	.
cord-319163-d1oj15cw	73	1	Furthermore	furthermore	RB
cord-319163-d1oj15cw	73	2	,	,	,
cord-319163-d1oj15cw	73	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	73	4	is	be	VBZ
cord-319163-d1oj15cw	73	5	a	a	DT
cord-319163-d1oj15cw	73	6	critical	critical	JJ
cord-319163-d1oj15cw	73	7	mediator	mediator	NN
cord-319163-d1oj15cw	73	8	of	of	IN
cord-319163-d1oj15cw	73	9	asthma	asthma	NN
cord-319163-d1oj15cw	73	10	exacerbations	exacerbation	NNS
cord-319163-d1oj15cw	73	11	due	due	JJ
cord-319163-d1oj15cw	73	12	to	to	IN
cord-319163-d1oj15cw	73	13	viral	viral	JJ
cord-319163-d1oj15cw	73	14	infection	infection	NN
cord-319163-d1oj15cw	73	15	as	as	RB
cord-319163-d1oj15cw	73	16	well	well	RB
cord-319163-d1oj15cw	73	17	as	as	IN
cord-319163-d1oj15cw	73	18	allergic	allergic	JJ
cord-319163-d1oj15cw	73	19	asthma	asthma	NN
cord-319163-d1oj15cw	73	20	(	(	-LRB-
cord-319163-d1oj15cw	73	21	14	14	CD
cord-319163-d1oj15cw	73	22	)	)	-RRB-
cord-319163-d1oj15cw	73	23	.	.	.
cord-319163-d1oj15cw	74	1	Viral	viral	JJ
cord-319163-d1oj15cw	74	2	infection	infection	NN
cord-319163-d1oj15cw	74	3	is	be	VBZ
cord-319163-d1oj15cw	74	4	associated	associate	VBN
cord-319163-d1oj15cw	74	5	with	with	IN
cord-319163-d1oj15cw	74	6	exacerbation	exacerbation	NN
cord-319163-d1oj15cw	74	7	of	of	IN
cord-319163-d1oj15cw	74	8	acute	acute	JJ
cord-319163-d1oj15cw	74	9	asthma	asthma	NN
cord-319163-d1oj15cw	74	10	.	.	.
cord-319163-d1oj15cw	75	1	Rhinovirus	rhinovirus	NN
cord-319163-d1oj15cw	75	2	,	,	,
cord-319163-d1oj15cw	75	3	severe	severe	JJ
cord-319163-d1oj15cw	75	4	respiratory	respiratory	JJ
cord-319163-d1oj15cw	75	5	syncytial	syncytial	JJ
cord-319163-d1oj15cw	75	6	virus	virus	NN
cord-319163-d1oj15cw	75	7	,	,	,
cord-319163-d1oj15cw	75	8	influenza	influenza	NN
cord-319163-d1oj15cw	75	9	viruses	virus	NNS
cord-319163-d1oj15cw	75	10	,	,	,
cord-319163-d1oj15cw	75	11	coronaviruses	coronaviruse	NNS
cord-319163-d1oj15cw	75	12	,	,	,
cord-319163-d1oj15cw	75	13	and	and	CC
cord-319163-d1oj15cw	75	14	adenoviruses	adenovirus	NNS
cord-319163-d1oj15cw	75	15	are	be	VBP
cord-319163-d1oj15cw	75	16	often	often	RB
cord-319163-d1oj15cw	75	17	detected	detect	VBN
cord-319163-d1oj15cw	75	18	in	in	IN
cord-319163-d1oj15cw	75	19	the	the	DT
cord-319163-d1oj15cw	75	20	airways	airways	NNPS
cord-319163-d1oj15cw	75	21	of	of	IN
cord-319163-d1oj15cw	75	22	asthma	asthma	NN
cord-319163-d1oj15cw	75	23	patients	patient	NNS
cord-319163-d1oj15cw	75	24	(	(	-LRB-
cord-319163-d1oj15cw	75	25	14	14	CD
cord-319163-d1oj15cw	75	26	)	)	-RRB-
cord-319163-d1oj15cw	75	27	.	.	.
cord-319163-d1oj15cw	76	1	Treatment	treatment	NN
cord-319163-d1oj15cw	76	2	with	with	IN
cord-319163-d1oj15cw	76	3	Baf	Baf	NNP
cord-319163-d1oj15cw	76	4	-	-	HYPH
cord-319163-d1oj15cw	76	5	A1	A1	NNP
cord-319163-d1oj15cw	76	6	inhibited	inhibit	VBN
cord-319163-d1oj15cw	76	7	vacuolar	vacuolar	JJ
cord-319163-d1oj15cw	76	8	-	-	HYPH
cord-319163-d1oj15cw	76	9	type	type	NN
cord-319163-d1oj15cw	76	10	H+-ATPase	h+-atpase	NN
cord-319163-d1oj15cw	76	11	-	-	HYPH
cord-319163-d1oj15cw	76	12	mediated	mediate	VBN
cord-319163-d1oj15cw	76	13	degradation	degradation	NN
cord-319163-d1oj15cw	76	14	of	of	IN
cord-319163-d1oj15cw	76	15	sequestered	sequester	VBN
cord-319163-d1oj15cw	76	16	material	material	NN
cord-319163-d1oj15cw	76	17	and	and	CC
cord-319163-d1oj15cw	76	18	blocked	block	VBD
cord-319163-d1oj15cw	76	19	autophagy	autophagy	NN
cord-319163-d1oj15cw	76	20	flux	flux	NN
cord-319163-d1oj15cw	76	21	by	by	IN
cord-319163-d1oj15cw	76	22	interfering	interfere	VBG
cord-319163-d1oj15cw	76	23	with	with	IN
cord-319163-d1oj15cw	76	24	late	late	JJ
cord-319163-d1oj15cw	76	25	-	-	HYPH
cord-319163-d1oj15cw	76	26	stage	stage	NN
cord-319163-d1oj15cw	76	27	autophagosome	autophagosome	NN
cord-319163-d1oj15cw	76	28	-	-	HYPH
cord-319163-d1oj15cw	76	29	lysosome	lysosome	NN
cord-319163-d1oj15cw	76	30	fusion	fusion	NN
cord-319163-d1oj15cw	76	31	in	in	IN
cord-319163-d1oj15cw	76	32	lung	lung	NN
cord-319163-d1oj15cw	76	33	epithelial	epithelial	JJ
cord-319163-d1oj15cw	76	34	cells	cell	NNS
cord-319163-d1oj15cw	76	35	,	,	,
cord-319163-d1oj15cw	76	36	resulting	result	VBG
cord-319163-d1oj15cw	76	37	in	in	IN
cord-319163-d1oj15cw	76	38	growth	growth	NN
cord-319163-d1oj15cw	76	39	inhibition	inhibition	NN
cord-319163-d1oj15cw	76	40	of	of	IN
cord-319163-d1oj15cw	76	41	influenza	influenza	NN
cord-319163-d1oj15cw	76	42	A	a	DT
cord-319163-d1oj15cw	76	43	viruses	virus	NNS
cord-319163-d1oj15cw	76	44	(	(	-LRB-
cord-319163-d1oj15cw	76	45	44	44	CD
cord-319163-d1oj15cw	76	46	)	)	-RRB-
cord-319163-d1oj15cw	76	47	.	.	.
cord-319163-d1oj15cw	77	1	An	an	DT
cord-319163-d1oj15cw	77	2	experimental	experimental	JJ
cord-319163-d1oj15cw	77	3	model	model	NN
cord-319163-d1oj15cw	77	4	based	base	VBN
cord-319163-d1oj15cw	77	5	on	on	IN
cord-319163-d1oj15cw	77	6	mouse	mouse	NN
cord-319163-d1oj15cw	77	7	hepatitis	hepatitis	NN
cord-319163-d1oj15cw	77	8	virus	virus	NN
cord-319163-d1oj15cw	77	9	(	(	-LRB-
cord-319163-d1oj15cw	77	10	MHV	MHV	NNP
cord-319163-d1oj15cw	77	11	)	)	-RRB-
cord-319163-d1oj15cw	77	12	,	,	,
cord-319163-d1oj15cw	77	13	a	a	DT
cord-319163-d1oj15cw	77	14	prototype	prototype	NN
cord-319163-d1oj15cw	77	15	coronavirus	coronavirus	NN
cord-319163-d1oj15cw	77	16	used	use	VBN
cord-319163-d1oj15cw	77	17	in	in	IN
cord-319163-d1oj15cw	77	18	replication	replication	NN
cord-319163-d1oj15cw	77	19	and	and	CC
cord-319163-d1oj15cw	77	20	function	function	NN
cord-319163-d1oj15cw	77	21	studies	study	NNS
cord-319163-d1oj15cw	77	22	,	,	,
cord-319163-d1oj15cw	77	23	revealed	reveal	VBD
cord-319163-d1oj15cw	77	24	that	that	IN
cord-319163-d1oj15cw	77	25	autophagy	autophagy	NN
cord-319163-d1oj15cw	77	26	is	be	VBZ
cord-319163-d1oj15cw	77	27	required	require	VBN
cord-319163-d1oj15cw	77	28	for	for	IN
cord-319163-d1oj15cw	77	29	viral	viral	JJ
cord-319163-d1oj15cw	77	30	replication	replication	NN
cord-319163-d1oj15cw	77	31	,	,	,
cord-319163-d1oj15cw	77	32	particularly	particularly	RB
cord-319163-d1oj15cw	77	33	for	for	IN
cord-319163-d1oj15cw	77	34	the	the	DT
cord-319163-d1oj15cw	77	35	formation	formation	NN
cord-319163-d1oj15cw	77	36	of	of	IN
cord-319163-d1oj15cw	77	37	double	double	JJ
cord-319163-d1oj15cw	77	38	membrane	membrane	NN
cord-319163-d1oj15cw	77	39	vesicle	vesicle	NN
cord-319163-d1oj15cw	77	40	-	-	HYPH
cord-319163-d1oj15cw	77	41	bound	bind	VBN
cord-319163-d1oj15cw	77	42	MHC	MHC	NNP
cord-319163-d1oj15cw	77	43	replication	replication	NN
cord-319163-d1oj15cw	77	44	complexes	complex	NNS
cord-319163-d1oj15cw	77	45	(	(	-LRB-
cord-319163-d1oj15cw	77	46	45	45	CD
cord-319163-d1oj15cw	77	47	)	)	-RRB-
cord-319163-d1oj15cw	77	48	.	.	.
cord-319163-d1oj15cw	78	1	Further	further	JJ
cord-319163-d1oj15cw	78	2	study	study	NN
cord-319163-d1oj15cw	78	3	revealed	reveal	VBD
cord-319163-d1oj15cw	78	4	that	that	IN
cord-319163-d1oj15cw	78	5	a	a	DT
cord-319163-d1oj15cw	78	6	coronavirus	coronavirus	NN
cord-319163-d1oj15cw	78	7	non	non	JJ
cord-319163-d1oj15cw	78	8	-	-	JJ
cord-319163-d1oj15cw	78	9	structural	structural	JJ
cord-319163-d1oj15cw	78	10	protein	protein	NN
cord-319163-d1oj15cw	78	11	6	6	CD
cord-319163-d1oj15cw	78	12	expressed	express	VBN
cord-319163-d1oj15cw	78	13	by	by	IN
cord-319163-d1oj15cw	78	14	the	the	DT
cord-319163-d1oj15cw	78	15	MHV	MHV	NNP
cord-319163-d1oj15cw	78	16	and	and	CC
cord-319163-d1oj15cw	78	17	severe	severe	JJ
cord-319163-d1oj15cw	78	18	acute	acute	JJ
cord-319163-d1oj15cw	78	19	respiratory	respiratory	JJ
cord-319163-d1oj15cw	78	20	syndrome	syndrome	NN
cord-319163-d1oj15cw	78	21	coronavirus	coronavirus	NN
cord-319163-d1oj15cw	78	22	activates	activate	VBZ
cord-319163-d1oj15cw	78	23	autophagy	autophagy	NN
cord-319163-d1oj15cw	78	24	by	by	IN
cord-319163-d1oj15cw	78	25	generating	generate	VBG
cord-319163-d1oj15cw	78	26	autophagosomes	autophagosome	NNS
cord-319163-d1oj15cw	78	27	independently	independently	RB
cord-319163-d1oj15cw	78	28	of	of	IN
cord-319163-d1oj15cw	78	29	starvation	starvation	NN
cord-319163-d1oj15cw	78	30	(	(	-LRB-
cord-319163-d1oj15cw	78	31	14,46	14,46	CD
cord-319163-d1oj15cw	78	32	)	)	-RRB-
cord-319163-d1oj15cw	78	33	.	.	.
cord-319163-d1oj15cw	79	1	Thus	thus	RB
cord-319163-d1oj15cw	79	2	,	,	,
cord-319163-d1oj15cw	79	3	given	give	VBN
cord-319163-d1oj15cw	79	4	its	-PRON-	PRP$
cord-319163-d1oj15cw	79	5	significant	significant	JJ
cord-319163-d1oj15cw	79	6	impact	impact	NN
cord-319163-d1oj15cw	79	7	on	on	IN
cord-319163-d1oj15cw	79	8	asthma	asthma	NN
cord-319163-d1oj15cw	79	9	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	79	10	,	,	,
cord-319163-d1oj15cw	79	11	further	further	JJ
cord-319163-d1oj15cw	79	12	studies	study	NNS
cord-319163-d1oj15cw	79	13	are	be	VBP
cord-319163-d1oj15cw	79	14	needed	need	VBN
cord-319163-d1oj15cw	79	15	to	to	TO
cord-319163-d1oj15cw	79	16	investigate	investigate	VB
cord-319163-d1oj15cw	79	17	the	the	DT
cord-319163-d1oj15cw	79	18	role	role	NN
cord-319163-d1oj15cw	79	19	of	of	IN
cord-319163-d1oj15cw	79	20	autophagy	autophagy	NN
cord-319163-d1oj15cw	79	21	in	in	IN
cord-319163-d1oj15cw	79	22	the	the	DT
cord-319163-d1oj15cw	79	23	context	context	NN
cord-319163-d1oj15cw	79	24	of	of	IN
cord-319163-d1oj15cw	79	25	different	different	JJ
cord-319163-d1oj15cw	79	26	cell	cell	NN
cord-319163-d1oj15cw	79	27	types	type	NNS
cord-319163-d1oj15cw	79	28	and	and	CC
cord-319163-d1oj15cw	79	29	to	to	TO
cord-319163-d1oj15cw	79	30	establish	establish	VB
cord-319163-d1oj15cw	79	31	a	a	DT
cord-319163-d1oj15cw	79	32	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	79	33	strategy	strategy	NN
cord-319163-d1oj15cw	79	34	for	for	IN
cord-319163-d1oj15cw	79	35	its	-PRON-	PRP$
cord-319163-d1oj15cw	79	36	regulation	regulation	NN
cord-319163-d1oj15cw	79	37	.	.	.
cord-319163-d1oj15cw	80	1	pollution	pollution	NN
cord-319163-d1oj15cw	80	2	is	be	VBZ
cord-319163-d1oj15cw	80	3	a	a	DT
cord-319163-d1oj15cw	80	4	main	main	JJ
cord-319163-d1oj15cw	80	5	cause	cause	NN
cord-319163-d1oj15cw	80	6	of	of	IN
cord-319163-d1oj15cw	80	7	COPD	COPD	NNP
cord-319163-d1oj15cw	80	8	;	;	:
cord-319163-d1oj15cw	80	9	indeed	indeed	RB
cord-319163-d1oj15cw	80	10	,	,	,
cord-319163-d1oj15cw	80	11	approximately	approximately	RB
cord-319163-d1oj15cw	80	12	15	15	CD
cord-319163-d1oj15cw	80	13	%	%	NN
cord-319163-d1oj15cw	80	14	of	of	IN
cord-319163-d1oj15cw	80	15	smokers	smoker	NNS
cord-319163-d1oj15cw	80	16	suffer	suffer	VBP
cord-319163-d1oj15cw	80	17	from	from	IN
cord-319163-d1oj15cw	80	18	this	this	DT
cord-319163-d1oj15cw	80	19	disease	disease	NN
cord-319163-d1oj15cw	80	20	(	(	-LRB-
cord-319163-d1oj15cw	80	21	49	49	CD
cord-319163-d1oj15cw	80	22	)	)	-RRB-
cord-319163-d1oj15cw	80	23	.	.	.
cord-319163-d1oj15cw	81	1	COPD	COPD	NNP
cord-319163-d1oj15cw	81	2	differs	differ	VBZ
cord-319163-d1oj15cw	81	3	from	from	IN
cord-319163-d1oj15cw	81	4	asthma	asthma	NN
cord-319163-d1oj15cw	81	5	in	in	IN
cord-319163-d1oj15cw	81	6	that	that	IN
cord-319163-d1oj15cw	81	7	the	the	DT
cord-319163-d1oj15cw	81	8	main	main	JJ
cord-319163-d1oj15cw	81	9	characteristic	characteristic	NN
cord-319163-d1oj15cw	81	10	is	be	VBZ
cord-319163-d1oj15cw	81	11	irreversible	irreversible	JJ
cord-319163-d1oj15cw	81	12	airflow	airflow	NN
cord-319163-d1oj15cw	81	13	obstruction	obstruction	NN
cord-319163-d1oj15cw	81	14	(	(	-LRB-
cord-319163-d1oj15cw	81	15	49	49	CD
cord-319163-d1oj15cw	81	16	,	,	,
cord-319163-d1oj15cw	81	17	50	50	CD
cord-319163-d1oj15cw	81	18	)	)	-RRB-
cord-319163-d1oj15cw	81	19	.	.	.
cord-319163-d1oj15cw	82	1	The	the	DT
cord-319163-d1oj15cw	82	2	physiological	physiological	JJ
cord-319163-d1oj15cw	82	3	abnormalities	abnormality	NNS
cord-319163-d1oj15cw	82	4	that	that	WDT
cord-319163-d1oj15cw	82	5	characterize	characterize	VBP
cord-319163-d1oj15cw	82	6	COPD	COPD	NNP
cord-319163-d1oj15cw	82	7	are	be	VBP
cord-319163-d1oj15cw	82	8	emphysema	emphysema	NN
cord-319163-d1oj15cw	82	9	and	and	CC
cord-319163-d1oj15cw	82	10	obliteration	obliteration	NN
cord-319163-d1oj15cw	82	11	of	of	IN
cord-319163-d1oj15cw	82	12	small	small	JJ
cord-319163-d1oj15cw	82	13	airways	airway	NNS
cord-319163-d1oj15cw	82	14	(	(	-LRB-
cord-319163-d1oj15cw	82	15	50	50	CD
cord-319163-d1oj15cw	82	16	)	)	-RRB-
cord-319163-d1oj15cw	82	17	.	.	.
cord-319163-d1oj15cw	83	1	Although	although	IN
cord-319163-d1oj15cw	83	2	emphysema	emphysema	NN
cord-319163-d1oj15cw	83	3	can	can	MD
cord-319163-d1oj15cw	83	4	occur	occur	VB
cord-319163-d1oj15cw	83	5	independently	independently	RB
cord-319163-d1oj15cw	83	6	of	of	IN
cord-319163-d1oj15cw	83	7	small	small	JJ
cord-319163-d1oj15cw	83	8	airway	airway	NN
cord-319163-d1oj15cw	83	9	narrowing	narrowing	NN
cord-319163-d1oj15cw	83	10	,	,	,
cord-319163-d1oj15cw	83	11	and	and	CC
cord-319163-d1oj15cw	83	12	vice	vice	NN
cord-319163-d1oj15cw	83	13	versa	versa	RB
cord-319163-d1oj15cw	83	14	,	,	,
cord-319163-d1oj15cw	83	15	these	these	DT
cord-319163-d1oj15cw	83	16	2	2	CD
cord-319163-d1oj15cw	83	17	pathologies	pathology	NNS
cord-319163-d1oj15cw	83	18	usually	usually	RB
cord-319163-d1oj15cw	83	19	coexist	coexist	VBP
cord-319163-d1oj15cw	83	20	in	in	IN
cord-319163-d1oj15cw	83	21	COPD	COPD	NNP
cord-319163-d1oj15cw	83	22	(	(	-LRB-
cord-319163-d1oj15cw	83	23	50	50	CD
cord-319163-d1oj15cw	83	24	)	)	-RRB-
cord-319163-d1oj15cw	83	25	.	.	.
cord-319163-d1oj15cw	84	1	Narrowing	narrow	VBG
cord-319163-d1oj15cw	84	2	of	of	IN
cord-319163-d1oj15cw	84	3	the	the	DT
cord-319163-d1oj15cw	84	4	small	small	JJ
cord-319163-d1oj15cw	84	5	airways	airways	NNPS
cord-319163-d1oj15cw	84	6	is	be	VBZ
cord-319163-d1oj15cw	84	7	caused	cause	VBN
cord-319163-d1oj15cw	84	8	by	by	IN
cord-319163-d1oj15cw	84	9	inflammation	inflammation	NN
cord-319163-d1oj15cw	84	10	,	,	,
cord-319163-d1oj15cw	84	11	increased	increase	VBN
cord-319163-d1oj15cw	84	12	airway	airway	NN
cord-319163-d1oj15cw	84	13	muscle	muscle	NN
cord-319163-d1oj15cw	84	14	mass	mass	NN
cord-319163-d1oj15cw	84	15	and	and	CC
cord-319163-d1oj15cw	84	16	fibrosis	fibrosis	NN
cord-319163-d1oj15cw	84	17	in	in	IN
cord-319163-d1oj15cw	84	18	the	the	DT
cord-319163-d1oj15cw	84	19	airway	airway	NN
cord-319163-d1oj15cw	84	20	wall	wall	NN
cord-319163-d1oj15cw	84	21	,	,	,
cord-319163-d1oj15cw	84	22	and	and	CC
cord-319163-d1oj15cw	84	23	accumulation	accumulation	NN
cord-319163-d1oj15cw	84	24	of	of	IN
cord-319163-d1oj15cw	84	25	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	84	26	mucus	mucus	NN
cord-319163-d1oj15cw	84	27	exudates	exudate	NNS
cord-319163-d1oj15cw	84	28	in	in	IN
cord-319163-d1oj15cw	84	29	the	the	DT
cord-319163-d1oj15cw	84	30	lumen	lumen	NN
cord-319163-d1oj15cw	84	31	(	(	-LRB-
cord-319163-d1oj15cw	84	32	50	50	CD
cord-319163-d1oj15cw	84	33	)	)	-RRB-
cord-319163-d1oj15cw	84	34	.	.	.
cord-319163-d1oj15cw	85	1	Although	although	IN
cord-319163-d1oj15cw	85	2	the	the	DT
cord-319163-d1oj15cw	85	3	major	major	JJ
cord-319163-d1oj15cw	85	4	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	85	5	cells	cell	NNS
cord-319163-d1oj15cw	85	6	involved	involve	VBN
cord-319163-d1oj15cw	85	7	in	in	IN
cord-319163-d1oj15cw	85	8	COPD	COPD	NNP
cord-319163-d1oj15cw	85	9	are	be	VBP
cord-319163-d1oj15cw	85	10	CD8	CD8	NNP
cord-319163-d1oj15cw	85	11	+	+	CC
cord-319163-d1oj15cw	85	12	T	T	NNP
cord-319163-d1oj15cw	85	13	cells	cell	NNS
cord-319163-d1oj15cw	85	14	,	,	,
cord-319163-d1oj15cw	85	15	neutrophils	neutrophil	NNS
cord-319163-d1oj15cw	85	16	and	and	CC
cord-319163-d1oj15cw	85	17	macrophages	macrophage	NNS
cord-319163-d1oj15cw	85	18	,	,	,
cord-319163-d1oj15cw	85	19	some	some	DT
cord-319163-d1oj15cw	85	20	patients	patient	NNS
cord-319163-d1oj15cw	85	21	have	have	VBP
cord-319163-d1oj15cw	85	22	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	85	23	involvement	involvement	NN
cord-319163-d1oj15cw	85	24	(	(	-LRB-
cord-319163-d1oj15cw	85	25	similar	similar	JJ
cord-319163-d1oj15cw	85	26	to	to	IN
cord-319163-d1oj15cw	85	27	that	that	DT
cord-319163-d1oj15cw	85	28	in	in	IN
cord-319163-d1oj15cw	85	29	asthma	asthma	NN
cord-319163-d1oj15cw	85	30	)	)	-RRB-
cord-319163-d1oj15cw	85	31	(	(	-LRB-
cord-319163-d1oj15cw	85	32	47	47	CD
cord-319163-d1oj15cw	85	33	)	)	-RRB-
cord-319163-d1oj15cw	85	34	.	.	.
cord-319163-d1oj15cw	86	1	As	as	IN
cord-319163-d1oj15cw	86	2	mentioned	mention	VBN
cord-319163-d1oj15cw	86	3	before	before	RB
cord-319163-d1oj15cw	86	4	,	,	,
cord-319163-d1oj15cw	86	5	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	86	6	migrate	migrate	VBP
cord-319163-d1oj15cw	86	7	in	in	IN
cord-319163-d1oj15cw	86	8	response	response	NN
cord-319163-d1oj15cw	86	9	to	to	IN
cord-319163-d1oj15cw	86	10	cytokines	cytokine	NNS
cord-319163-d1oj15cw	86	11	(	(	-LRB-
cord-319163-d1oj15cw	86	12	IL-5	IL-5	NNP
cord-319163-d1oj15cw	86	13	in	in	IN
cord-319163-d1oj15cw	86	14	particular	particular	JJ
cord-319163-d1oj15cw	86	15	)	)	-RRB-
cord-319163-d1oj15cw	86	16	and	and	CC
cord-319163-d1oj15cw	86	17	specific	specific	JJ
cord-319163-d1oj15cw	86	18	chemokines	chemokine	NNS
cord-319163-d1oj15cw	86	19	(	(	-LRB-
cord-319163-d1oj15cw	86	20	such	such	JJ
cord-319163-d1oj15cw	86	21	as	as	IN
cord-319163-d1oj15cw	86	22	eotaxin	eotaxin	NNP
cord-319163-d1oj15cw	86	23	I	I	NNP
cord-319163-d1oj15cw	86	24	and	and	CC
cord-319163-d1oj15cw	86	25	RANTES	RANTES	NNP
cord-319163-d1oj15cw	86	26	)	)	-RRB-
cord-319163-d1oj15cw	86	27	.	.	.
cord-319163-d1oj15cw	87	1	Exacerbation	exacerbation	NN
cord-319163-d1oj15cw	87	2	of	of	IN
cord-319163-d1oj15cw	87	3	COPD	COPD	NNP
cord-319163-d1oj15cw	87	4	is	be	VBZ
cord-319163-d1oj15cw	87	5	triggered	trigger	VBN
cord-319163-d1oj15cw	87	6	by	by	IN
cord-319163-d1oj15cw	87	7	persistent	persistent	JJ
cord-319163-d1oj15cw	87	8	inflammation	inflammation	NN
cord-319163-d1oj15cw	87	9	,	,	,
cord-319163-d1oj15cw	87	10	which	which	WDT
cord-319163-d1oj15cw	87	11	is	be	VBZ
cord-319163-d1oj15cw	87	12	itself	-PRON-	PRP
cord-319163-d1oj15cw	87	13	caused	cause	VBN
cord-319163-d1oj15cw	87	14	by	by	IN
cord-319163-d1oj15cw	87	15	eosinophil	eosinophil	NN
cord-319163-d1oj15cw	87	16	-	-	HYPH
cord-319163-d1oj15cw	87	17	derived	derive	VBN
cord-319163-d1oj15cw	87	18	proinflammatory	proinflammatory	JJ
cord-319163-d1oj15cw	87	19	mediators	mediator	NNS
cord-319163-d1oj15cw	87	20	such	such	JJ
cord-319163-d1oj15cw	87	21	as	as	IN
cord-319163-d1oj15cw	87	22	basic	basic	JJ
cord-319163-d1oj15cw	87	23	proteins	protein	NNS
cord-319163-d1oj15cw	87	24	,	,	,
cord-319163-d1oj15cw	87	25	cytokines	cytokine	NNS
cord-319163-d1oj15cw	87	26	,	,	,
cord-319163-d1oj15cw	87	27	and	and	CC
cord-319163-d1oj15cw	87	28	growth	growth	NN
cord-319163-d1oj15cw	87	29	factors	factor	NNS
cord-319163-d1oj15cw	87	30	(	(	-LRB-
cord-319163-d1oj15cw	87	31	51	51	CD
cord-319163-d1oj15cw	87	32	)	)	-RRB-
cord-319163-d1oj15cw	87	33	.	.	.
cord-319163-d1oj15cw	88	1	Recent	recent	JJ
cord-319163-d1oj15cw	88	2	studies	study	NNS
cord-319163-d1oj15cw	88	3	demonstrate	demonstrate	VBP
cord-319163-d1oj15cw	88	4	an	an	DT
cord-319163-d1oj15cw	88	5	association	association	NN
cord-319163-d1oj15cw	88	6	between	between	IN
cord-319163-d1oj15cw	88	7	autophagy	autophagy	NN
cord-319163-d1oj15cw	88	8	and	and	CC
cord-319163-d1oj15cw	88	9	COPD	COPD	NNP
cord-319163-d1oj15cw	88	10	(	(	-LRB-
cord-319163-d1oj15cw	88	11	Table	table	NN
cord-319163-d1oj15cw	88	12	1	1	CD
cord-319163-d1oj15cw	88	13	)	)	-RRB-
cord-319163-d1oj15cw	88	14	(	(	-LRB-
cord-319163-d1oj15cw	88	15	52	52	CD
cord-319163-d1oj15cw	88	16	)	)	-RRB-
cord-319163-d1oj15cw	88	17	(	(	-LRB-
cord-319163-d1oj15cw	88	18	53	53	CD
cord-319163-d1oj15cw	88	19	)	)	-RRB-
cord-319163-d1oj15cw	88	20	(	(	-LRB-
cord-319163-d1oj15cw	88	21	54	54	CD
cord-319163-d1oj15cw	88	22	)	)	-RRB-
cord-319163-d1oj15cw	88	23	.	.	.
cord-319163-d1oj15cw	89	1	Chen	Chen	NNP
cord-319163-d1oj15cw	89	2	et	et	NNP
cord-319163-d1oj15cw	89	3	al	al	NNP
cord-319163-d1oj15cw	89	4	.	.	.
cord-319163-d1oj15cw	90	1	(	(	-LRB-
cord-319163-d1oj15cw	90	2	52	52	CD
cord-319163-d1oj15cw	90	3	)	)	-RRB-
cord-319163-d1oj15cw	90	4	showed	show	VBD
cord-319163-d1oj15cw	90	5	that	that	IN
cord-319163-d1oj15cw	90	6	expression	expression	NN
cord-319163-d1oj15cw	90	7	of	of	IN
cord-319163-d1oj15cw	90	8	LC3B	LC3B	NNP
cord-319163-d1oj15cw	90	9	-	-	HYPH
cord-319163-d1oj15cw	90	10	II	II	NNP
cord-319163-d1oj15cw	90	11	,	,	,
cord-319163-d1oj15cw	90	12	ATG4	ATG4	NNP
cord-319163-d1oj15cw	90	13	,	,	,
cord-319163-d1oj15cw	90	14	ATG5	ATG5	NNP
cord-319163-d1oj15cw	90	15	,	,	,
cord-319163-d1oj15cw	90	16	ATG12	ATG12	NNP
cord-319163-d1oj15cw	90	17	,	,	,
cord-319163-d1oj15cw	90	18	and	and	CC
cord-319163-d1oj15cw	90	19	ATG7	ATG7	NNP
cord-319163-d1oj15cw	90	20	is	be	VBZ
cord-319163-d1oj15cw	90	21	higher	high	JJR
cord-319163-d1oj15cw	90	22	in	in	IN
cord-319163-d1oj15cw	90	23	individuals	individual	NNS
cord-319163-d1oj15cw	90	24	with	with	IN
cord-319163-d1oj15cw	90	25	COPD	COPD	NNP
cord-319163-d1oj15cw	90	26	than	than	IN
cord-319163-d1oj15cw	90	27	in	in	IN
cord-319163-d1oj15cw	90	28	those	those	DT
cord-319163-d1oj15cw	90	29	without	without	IN
cord-319163-d1oj15cw	90	30	,	,	,
cord-319163-d1oj15cw	90	31	and	and	CC
cord-319163-d1oj15cw	90	32	that	that	DT
cord-319163-d1oj15cw	90	33	treatment	treatment	NN
cord-319163-d1oj15cw	90	34	of	of	IN
cord-319163-d1oj15cw	90	35	primary	primary	JJ
cord-319163-d1oj15cw	90	36	human	human	JJ
cord-319163-d1oj15cw	90	37	bronchial	bronchial	JJ
cord-319163-d1oj15cw	90	38	epithelial	epithelial	JJ
cord-319163-d1oj15cw	90	39	cells	cell	NNS
cord-319163-d1oj15cw	90	40	with	with	IN
cord-319163-d1oj15cw	90	41	aqueous	aqueous	JJ
cord-319163-d1oj15cw	90	42	cigarette	cigarette	NN
cord-319163-d1oj15cw	90	43	-	-	HYPH
cord-319163-d1oj15cw	90	44	smoke	smoke	NN
cord-319163-d1oj15cw	90	45	(	(	-LRB-
cord-319163-d1oj15cw	90	46	CS	CS	NNP
cord-319163-d1oj15cw	90	47	)	)	-RRB-
cord-319163-d1oj15cw	90	48	extract	extract	NN
cord-319163-d1oj15cw	90	49	induces	induce	VBZ
cord-319163-d1oj15cw	90	50	LC3B	lc3b	NN
cord-319163-d1oj15cw	90	51	-	-	HYPH
cord-319163-d1oj15cw	90	52	II	II	NNP
cord-319163-d1oj15cw	90	53	.	.	.
cord-319163-d1oj15cw	91	1	They	-PRON-	PRP
cord-319163-d1oj15cw	91	2	also	also	RB
cord-319163-d1oj15cw	91	3	demonstrated	demonstrate	VBD
cord-319163-d1oj15cw	91	4	a	a	DT
cord-319163-d1oj15cw	91	5	regulatory	regulatory	JJ
cord-319163-d1oj15cw	91	6	role	role	NN
cord-319163-d1oj15cw	91	7	for	for	IN
cord-319163-d1oj15cw	91	8	LC3B	lc3b	NN
cord-319163-d1oj15cw	91	9	during	during	IN
cord-319163-d1oj15cw	91	10	epithelial	epithelial	JJ
cord-319163-d1oj15cw	91	11	cell	cell	NN
cord-319163-d1oj15cw	91	12	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	91	13	in	in	IN
cord-319163-d1oj15cw	91	14	a	a	DT
cord-319163-d1oj15cw	91	15	CS	cs	NN
cord-319163-d1oj15cw	91	16	-	-	HYPH
cord-319163-d1oj15cw	91	17	induced	induce	VBN
cord-319163-d1oj15cw	91	18	lung	lung	NN
cord-319163-d1oj15cw	91	19	cell	cell	NN
cord-319163-d1oj15cw	91	20	injury	injury	NN
cord-319163-d1oj15cw	91	21	model	model	NN
cord-319163-d1oj15cw	91	22	(	(	-LRB-
cord-319163-d1oj15cw	91	23	52	52	CD
cord-319163-d1oj15cw	91	24	,	,	,
cord-319163-d1oj15cw	91	25	53	53	CD
cord-319163-d1oj15cw	91	26	)	)	-RRB-
cord-319163-d1oj15cw	91	27	.	.	.
cord-319163-d1oj15cw	92	1	Apoptosis	apoptosis	NN
cord-319163-d1oj15cw	92	2	is	be	VBZ
cord-319163-d1oj15cw	92	3	implicated	implicate	VBN
cord-319163-d1oj15cw	92	4	in	in	IN
cord-319163-d1oj15cw	92	5	the	the	DT
cord-319163-d1oj15cw	92	6	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	92	7	of	of	IN
cord-319163-d1oj15cw	92	8	COPD	COPD	NNP
cord-319163-d1oj15cw	92	9	.	.	.
cord-319163-d1oj15cw	93	1	Treatment	treatment	NN
cord-319163-d1oj15cw	93	2	of	of	IN
cord-319163-d1oj15cw	93	3	epithelial	epithelial	JJ
cord-319163-d1oj15cw	93	4	cells	cell	NNS
cord-319163-d1oj15cw	93	5	with	with	IN
cord-319163-d1oj15cw	93	6	CS	CS	NNP
cord-319163-d1oj15cw	93	7	extract	extract	NN
cord-319163-d1oj15cw	93	8	initiates	initiate	VBZ
cord-319163-d1oj15cw	93	9	the	the	DT
cord-319163-d1oj15cw	93	10	extrinsic	extrinsic	JJ
cord-319163-d1oj15cw	93	11	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	93	12	pathway	pathway	NN
cord-319163-d1oj15cw	93	13	,	,	,
cord-319163-d1oj15cw	93	14	which	which	WDT
cord-319163-d1oj15cw	93	15	involves	involve	VBZ
cord-319163-d1oj15cw	93	16	assembly	assembly	NN
cord-319163-d1oj15cw	93	17	of	of	IN
cord-319163-d1oj15cw	93	18	the	the	DT
cord-319163-d1oj15cw	93	19	Fas	Fas	NNP
cord-319163-d1oj15cw	93	20	-	-	HYPH
cord-319163-d1oj15cw	93	21	dependent	dependent	JJ
cord-319163-d1oj15cw	93	22	death	death	NN
cord-319163-d1oj15cw	93	23	-	-	HYPH
cord-319163-d1oj15cw	93	24	inducing	induce	VBG
cord-319163-d1oj15cw	93	25	signaling	signal	VBG
cord-319163-d1oj15cw	93	26	complex	complex	NN
cord-319163-d1oj15cw	93	27	(	(	-LRB-
cord-319163-d1oj15cw	93	28	DISC	disc	NN
cord-319163-d1oj15cw	93	29	)	)	-RRB-
cord-319163-d1oj15cw	93	30	and	and	CC
cord-319163-d1oj15cw	93	31	activation	activation	NN
cord-319163-d1oj15cw	93	32	of	of	IN
cord-319163-d1oj15cw	93	33	caspase-8	caspase-8	NNP
cord-319163-d1oj15cw	93	34	;	;	:
cord-319163-d1oj15cw	93	35	it	-PRON-	PRP
cord-319163-d1oj15cw	93	36	also	also	RB
cord-319163-d1oj15cw	93	37	induced	induce	VBD
cord-319163-d1oj15cw	93	38	expression	expression	NN
cord-319163-d1oj15cw	93	39	and	and	CC
cord-319163-d1oj15cw	93	40	conversion	conversion	NN
cord-319163-d1oj15cw	93	41	of	of	IN
cord-319163-d1oj15cw	93	42	the	the	DT
cord-319163-d1oj15cw	93	43	autophagic	autophagic	JJ
cord-319163-d1oj15cw	93	44	regulator	regulator	NN
cord-319163-d1oj15cw	93	45	LC3B	LC3B	NNS
cord-319163-d1oj15cw	93	46	,	,	,
cord-319163-d1oj15cw	93	47	increased	increase	VBN
cord-319163-d1oj15cw	93	48	autophagosome	autophagosome	JJ
cord-319163-d1oj15cw	93	49	formation	formation	NN
cord-319163-d1oj15cw	93	50	,	,	,
cord-319163-d1oj15cw	93	51	and	and	CC
cord-319163-d1oj15cw	93	52	increased	increase	VBD
cord-319163-d1oj15cw	93	53	caspase-3	caspase-3	NNP
cord-319163-d1oj15cw	93	54	activation	activation	NN
cord-319163-d1oj15cw	93	55	.	.	.
cord-319163-d1oj15cw	94	1	siRNAmediated	sirnamediated	JJ
cord-319163-d1oj15cw	94	2	knockdown	knockdown	NN
cord-319163-d1oj15cw	94	3	of	of	IN
cord-319163-d1oj15cw	94	4	autophagic	autophagic	NNP
cord-319163-d1oj15cw	94	5	proteins	protein	NNS
cord-319163-d1oj15cw	94	6	Beclin-1	Beclin-1	NNP
cord-319163-d1oj15cw	94	7	or	or	CC
cord-319163-d1oj15cw	94	8	LC3B	lc3b	NN
cord-319163-d1oj15cw	94	9	in	in	IN
cord-319163-d1oj15cw	94	10	epithelial	epithelial	JJ
cord-319163-d1oj15cw	94	11	cells	cell	NNS
cord-319163-d1oj15cw	94	12	inhibits	inhibit	VBZ
cord-319163-d1oj15cw	94	13	assembly	assembly	NN
cord-319163-d1oj15cw	94	14	of	of	IN
cord-319163-d1oj15cw	94	15	the	the	DT
cord-319163-d1oj15cw	94	16	Fas	Fas	NNP
cord-319163-d1oj15cw	94	17	-	-	HYPH
cord-319163-d1oj15cw	94	18	dependent	dependent	JJ
cord-319163-d1oj15cw	94	19	DISC	DISC	NNP
cord-319163-d1oj15cw	94	20	(	(	-LRB-
cord-319163-d1oj15cw	94	21	52	52	CD
cord-319163-d1oj15cw	94	22	,	,	,
cord-319163-d1oj15cw	94	23	53	53	CD
cord-319163-d1oj15cw	94	24	)	)	-RRB-
cord-319163-d1oj15cw	94	25	.	.	.
cord-319163-d1oj15cw	95	1	Moreover	moreover	RB
cord-319163-d1oj15cw	95	2	,	,	,
cord-319163-d1oj15cw	95	3	apoptotic	apoptotic	JJ
cord-319163-d1oj15cw	95	4	indices	index	NNS
cord-319163-d1oj15cw	95	5	and	and	CC
cord-319163-d1oj15cw	95	6	emphysema	emphysema	NN
cord-319163-d1oj15cw	95	7	development	development	NN
cord-319163-d1oj15cw	95	8	were	be	VBD
cord-319163-d1oj15cw	95	9	reduced	reduce	VBN
cord-319163-d1oj15cw	95	10	markedly	markedly	RB
cord-319163-d1oj15cw	95	11	in	in	IN
cord-319163-d1oj15cw	95	12	LC3B	lc3b	NN
cord-319163-d1oj15cw	95	13	knock	knock	VB
cord-319163-d1oj15cw	95	14	-	-	HYPH
cord-319163-d1oj15cw	95	15	out	out	RP
cord-319163-d1oj15cw	95	16	mice	mouse	NNS
cord-319163-d1oj15cw	95	17	exposed	expose	VBN
cord-319163-d1oj15cw	95	18	to	to	IN
cord-319163-d1oj15cw	95	19	CS	CS	NNP
cord-319163-d1oj15cw	95	20	(	(	-LRB-
cord-319163-d1oj15cw	95	21	54	54	CD
cord-319163-d1oj15cw	95	22	)	)	-RRB-
cord-319163-d1oj15cw	95	23	.	.	.
cord-319163-d1oj15cw	96	1	The	the	DT
cord-319163-d1oj15cw	96	2	mechanism	mechanism	NN
cord-319163-d1oj15cw	96	3	by	by	IN
cord-319163-d1oj15cw	96	4	which	which	WDT
cord-319163-d1oj15cw	96	5	CS	CS	NNP
cord-319163-d1oj15cw	96	6	induces	induce	VBZ
cord-319163-d1oj15cw	96	7	autophagy	autophagy	NN
cord-319163-d1oj15cw	96	8	in	in	IN
cord-319163-d1oj15cw	96	9	epithelial	epithelial	JJ
cord-319163-d1oj15cw	96	10	cells	cell	NNS
cord-319163-d1oj15cw	96	11	is	be	VBZ
cord-319163-d1oj15cw	96	12	unclear	unclear	JJ
cord-319163-d1oj15cw	96	13	;	;	:
cord-319163-d1oj15cw	96	14	however	however	RB
cord-319163-d1oj15cw	96	15	,	,	,
cord-319163-d1oj15cw	96	16	oxidative	oxidative	JJ
cord-319163-d1oj15cw	96	17	stress	stress	NN
cord-319163-d1oj15cw	96	18	is	be	VBZ
cord-319163-d1oj15cw	96	19	a	a	DT
cord-319163-d1oj15cw	96	20	possible	possible	JJ
cord-319163-d1oj15cw	96	21	link	link	NN
cord-319163-d1oj15cw	96	22	that	that	WDT
cord-319163-d1oj15cw	96	23	connects	connect	VBZ
cord-319163-d1oj15cw	96	24	COPD	COPD	NNP
cord-319163-d1oj15cw	96	25	to	to	TO
cord-319163-d1oj15cw	96	26	autophagy	autophagy	VB
cord-319163-d1oj15cw	96	27	.	.	.
cord-319163-d1oj15cw	97	1	Oxidative	oxidative	JJ
cord-319163-d1oj15cw	97	2	stress	stress	NN
cord-319163-d1oj15cw	97	3	can	can	MD
cord-319163-d1oj15cw	97	4	damage	damage	VB
cord-319163-d1oj15cw	97	5	lipids	lipid	NNS
cord-319163-d1oj15cw	97	6	,	,	,
cord-319163-d1oj15cw	97	7	proteins	protein	NNS
cord-319163-d1oj15cw	97	8	and	and	CC
cord-319163-d1oj15cw	97	9	DNA	dna	NN
cord-319163-d1oj15cw	97	10	,	,	,
cord-319163-d1oj15cw	97	11	and	and	CC
cord-319163-d1oj15cw	97	12	also	also	RB
cord-319163-d1oj15cw	97	13	activate	activate	VB
cord-319163-d1oj15cw	97	14	autophagy	autophagy	NN
cord-319163-d1oj15cw	97	15	(	(	-LRB-
cord-319163-d1oj15cw	97	16	55	55	CD
cord-319163-d1oj15cw	97	17	)	)	-RRB-
cord-319163-d1oj15cw	97	18	.	.	.
cord-319163-d1oj15cw	98	1	Furthermore	furthermore	RB
cord-319163-d1oj15cw	98	2	,	,	,
cord-319163-d1oj15cw	98	3	it	-PRON-	PRP
cord-319163-d1oj15cw	98	4	is	be	VBZ
cord-319163-d1oj15cw	98	5	recognized	recognize	VBN
cord-319163-d1oj15cw	98	6	as	as	IN
cord-319163-d1oj15cw	98	7	a	a	DT
cord-319163-d1oj15cw	98	8	major	major	JJ
cord-319163-d1oj15cw	98	9	factor	factor	NN
cord-319163-d1oj15cw	98	10	that	that	WDT
cord-319163-d1oj15cw	98	11	predisposes	predispose	VBZ
cord-319163-d1oj15cw	98	12	an	an	DT
cord-319163-d1oj15cw	98	13	individual	individual	NN
cord-319163-d1oj15cw	98	14	to	to	IN
cord-319163-d1oj15cw	98	15	developing	develop	VBG
cord-319163-d1oj15cw	98	16	COPD	COPD	NNP
cord-319163-d1oj15cw	98	17	(	(	-LRB-
cord-319163-d1oj15cw	98	18	56	56	CD
cord-319163-d1oj15cw	98	19	)	)	-RRB-
cord-319163-d1oj15cw	98	20	.	.	.
cord-319163-d1oj15cw	99	1	Various	various	JJ
cord-319163-d1oj15cw	99	2	types	type	NNS
cord-319163-d1oj15cw	99	3	of	of	IN
cord-319163-d1oj15cw	99	4	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	99	5	cell	cell	NN
cord-319163-d1oj15cw	99	6	including	include	VBG
cord-319163-d1oj15cw	99	7	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	99	8	and	and	CC
cord-319163-d1oj15cw	99	9	structural	structural	JJ
cord-319163-d1oj15cw	99	10	cells	cell	NNS
cord-319163-d1oj15cw	99	11	produce	produce	VBP
cord-319163-d1oj15cw	99	12	ROS	ROS	NNP
cord-319163-d1oj15cw	99	13	in	in	IN
cord-319163-d1oj15cw	99	14	the	the	DT
cord-319163-d1oj15cw	99	15	airways	airways	NNPS
cord-319163-d1oj15cw	99	16	of	of	IN
cord-319163-d1oj15cw	99	17	a	a	DT
cord-319163-d1oj15cw	99	18	COPD	COPD	NNP
cord-319163-d1oj15cw	99	19	patient	patient	NN
cord-319163-d1oj15cw	99	20	(	(	-LRB-
cord-319163-d1oj15cw	99	21	56	56	CD
cord-319163-d1oj15cw	99	22	,	,	,
cord-319163-d1oj15cw	99	23	57	57	CD
cord-319163-d1oj15cw	99	24	)	)	-RRB-
cord-319163-d1oj15cw	99	25	.	.	.
cord-319163-d1oj15cw	100	1	Treatment	treatment	NN
cord-319163-d1oj15cw	100	2	with	with	IN
cord-319163-d1oj15cw	100	3	the	the	DT
cord-319163-d1oj15cw	100	4	antioxidants	antioxidant	NNS
cord-319163-d1oj15cw	100	5	such	such	JJ
cord-319163-d1oj15cw	100	6	as	as	IN
cord-319163-d1oj15cw	100	7	N	n	CD
cord-319163-d1oj15cw	100	8	-	-	HYPH
cord-319163-d1oj15cw	100	9	acetyl	acetyl	NNP
cord-319163-d1oj15cw	100	10	-	-	HYPH
cord-319163-d1oj15cw	100	11	Lcysteine	Lcysteine	NNP
cord-319163-d1oj15cw	100	12	reverses	reverse	VBZ
cord-319163-d1oj15cw	100	13	starvation	starvation	NN
cord-319163-d1oj15cw	100	14	-	-	HYPH
cord-319163-d1oj15cw	100	15	induced	induce	VBN
cord-319163-d1oj15cw	100	16	autophagosome	autophagosome	NN
cord-319163-d1oj15cw	100	17	formation	formation	NN
cord-319163-d1oj15cw	100	18	(	(	-LRB-
cord-319163-d1oj15cw	100	19	which	which	WDT
cord-319163-d1oj15cw	100	20	is	be	VBZ
cord-319163-d1oj15cw	100	21	associated	associate	VBN
cord-319163-d1oj15cw	100	22	with	with	IN
cord-319163-d1oj15cw	100	23	intracellular	intracellular	JJ
cord-319163-d1oj15cw	100	24	ROS	ROS	NNP
cord-319163-d1oj15cw	100	25	production	production	NN
cord-319163-d1oj15cw	100	26	)	)	-RRB-
cord-319163-d1oj15cw	100	27	in	in	IN
cord-319163-d1oj15cw	100	28	cultured	cultured	JJ
cord-319163-d1oj15cw	100	29	cells	cell	NNS
cord-319163-d1oj15cw	100	30	(	(	-LRB-
cord-319163-d1oj15cw	100	31	58	58	CD
cord-319163-d1oj15cw	100	32	)	)	-RRB-
cord-319163-d1oj15cw	100	33	.	.	.
cord-319163-d1oj15cw	101	1	H	h	NN
cord-319163-d1oj15cw	101	2	2	2	CD
cord-319163-d1oj15cw	101	3	O	o	NN
cord-319163-d1oj15cw	101	4	2	2	CD
cord-319163-d1oj15cw	101	5	-induced	-induce	VBN
cord-319163-d1oj15cw	101	6	autophagic	autophagic	JJ
cord-319163-d1oj15cw	101	7	cell	cell	NN
cord-319163-d1oj15cw	101	8	death	death	NN
cord-319163-d1oj15cw	101	9	can	can	MD
cord-319163-d1oj15cw	101	10	be	be	VB
cord-319163-d1oj15cw	101	11	prevented	prevent	VBN
cord-319163-d1oj15cw	101	12	by	by	IN
cord-319163-d1oj15cw	101	13	knockdown	knockdown	NN
cord-319163-d1oj15cw	101	14	of	of	IN
cord-319163-d1oj15cw	101	15	ATG	ATG	NNP
cord-319163-d1oj15cw	101	16	such	such	JJ
cord-319163-d1oj15cw	101	17	as	as	IN
cord-319163-d1oj15cw	101	18	Beclin-1	Beclin-1	NNP
cord-319163-d1oj15cw	101	19	,	,	,
cord-319163-d1oj15cw	101	20	Atg5	Atg5	NNP
cord-319163-d1oj15cw	101	21	,	,	,
cord-319163-d1oj15cw	101	22	and	and	CC
cord-319163-d1oj15cw	101	23	Atg7	Atg7	NNP
cord-319163-d1oj15cw	101	24	(	(	-LRB-
cord-319163-d1oj15cw	101	25	59	59	CD
cord-319163-d1oj15cw	101	26	)	)	-RRB-
cord-319163-d1oj15cw	101	27	.	.	.
cord-319163-d1oj15cw	102	1	Indeed	indeed	RB
cord-319163-d1oj15cw	102	2	,	,	,
cord-319163-d1oj15cw	102	3	exposure	exposure	NN
cord-319163-d1oj15cw	102	4	to	to	IN
cord-319163-d1oj15cw	102	5	CS	CS	NNP
cord-319163-d1oj15cw	102	6	induces	induce	VBZ
cord-319163-d1oj15cw	102	7	pro	pro	JJ
cord-319163-d1oj15cw	102	8	-	-	JJ
cord-319163-d1oj15cw	102	9	oxidant	oxidant	JJ
cord-319163-d1oj15cw	102	10	states	state	NNS
cord-319163-d1oj15cw	102	11	in	in	IN
cord-319163-d1oj15cw	102	12	several	several	JJ
cord-319163-d1oj15cw	102	13	cell	cell	NN
cord-319163-d1oj15cw	102	14	types	type	NNS
cord-319163-d1oj15cw	102	15	,	,	,
cord-319163-d1oj15cw	102	16	including	include	VBG
cord-319163-d1oj15cw	102	17	epithelial	epithelial	JJ
cord-319163-d1oj15cw	102	18	cells	cell	NNS
cord-319163-d1oj15cw	102	19	(	(	-LRB-
cord-319163-d1oj15cw	102	20	60	60	CD
cord-319163-d1oj15cw	102	21	)	)	-RRB-
cord-319163-d1oj15cw	102	22	.	.	.
cord-319163-d1oj15cw	103	1	In	in	IN
cord-319163-d1oj15cw	103	2	addition	addition	NN
cord-319163-d1oj15cw	103	3	,	,	,
cord-319163-d1oj15cw	103	4	chemical	chemical	NN
cord-319163-d1oj15cw	103	5	inhibitors	inhibitor	NNS
cord-319163-d1oj15cw	103	6	of	of	IN
cord-319163-d1oj15cw	103	7	NADPH	NADPH	NNP
cord-319163-d1oj15cw	103	8	oxidase	oxidase	NN
cord-319163-d1oj15cw	103	9	,	,	,
cord-319163-d1oj15cw	103	10	a	a	DT
cord-319163-d1oj15cw	103	11	membrane	membrane	NN
cord-319163-d1oj15cw	103	12	-	-	HYPH
cord-319163-d1oj15cw	103	13	dependent	dependent	JJ
cord-319163-d1oj15cw	103	14	source	source	NN
cord-319163-d1oj15cw	103	15	of	of	IN
cord-319163-d1oj15cw	103	16	ROS	ROS	NNP
cord-319163-d1oj15cw	103	17	,	,	,
cord-319163-d1oj15cw	103	18	inhibit	inhibit	VB
cord-319163-d1oj15cw	103	19	CS	CS	NNP
cord-319163-d1oj15cw	103	20	extract	extract	NN
cord-319163-d1oj15cw	103	21	-	-	HYPH
cord-319163-d1oj15cw	103	22	induced	induce	VBN
cord-319163-d1oj15cw	103	23	activation	activation	NN
cord-319163-d1oj15cw	103	24	of	of	IN
cord-319163-d1oj15cw	103	25	LC3B	lc3b	NN
cord-319163-d1oj15cw	103	26	(	(	-LRB-
cord-319163-d1oj15cw	103	27	54	54	CD
cord-319163-d1oj15cw	103	28	)	)	-RRB-
cord-319163-d1oj15cw	103	29	.	.	.
cord-319163-d1oj15cw	104	1	The	the	DT
cord-319163-d1oj15cw	104	2	evidence	evidence	NN
cord-319163-d1oj15cw	104	3	cited	cite	VBN
cord-319163-d1oj15cw	104	4	above	above	RB
cord-319163-d1oj15cw	104	5	suggests	suggest	VBZ
cord-319163-d1oj15cw	104	6	that	that	IN
cord-319163-d1oj15cw	104	7	increased	increase	VBN
cord-319163-d1oj15cw	104	8	activation	activation	NN
cord-319163-d1oj15cw	104	9	of	of	IN
cord-319163-d1oj15cw	104	10	autophagic	autophagic	JJ
cord-319163-d1oj15cw	104	11	pathways	pathway	NNS
cord-319163-d1oj15cw	104	12	may	may	MD
cord-319163-d1oj15cw	104	13	trigger	trigger	VB
cord-319163-d1oj15cw	104	14	or	or	CC
cord-319163-d1oj15cw	104	15	exacerbate	exacerbate	VB
cord-319163-d1oj15cw	104	16	COPD	COPD	NNP
cord-319163-d1oj15cw	104	17	.	.	.
cord-319163-d1oj15cw	105	1	Thus	thus	RB
cord-319163-d1oj15cw	105	2	,	,	,
cord-319163-d1oj15cw	105	3	resolution	resolution	NN
cord-319163-d1oj15cw	105	4	of	of	IN
cord-319163-d1oj15cw	105	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	105	6	should	should	MD
cord-319163-d1oj15cw	105	7	be	be	VB
cord-319163-d1oj15cw	105	8	studied	study	VBN
cord-319163-d1oj15cw	105	9	with	with	IN
cord-319163-d1oj15cw	105	10	respect	respect	NN
cord-319163-d1oj15cw	105	11	to	to	IN
cord-319163-d1oj15cw	105	12	alleviating	alleviate	VBG
cord-319163-d1oj15cw	105	13	COPD	COPD	NNP
cord-319163-d1oj15cw	105	14	.	.	.
cord-319163-d1oj15cw	106	1	Autophagy	autophagy	JJ
cord-319163-d1oj15cw	106	2	and	and	CC
cord-319163-d1oj15cw	106	3	Eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	106	4	Airway	Airway	NNP
cord-319163-d1oj15cw	106	5	Inflammation	inflammation	NN
cord-319163-d1oj15cw	106	6	https://immunenetwork.org	https://immunenetwork.org	NFP
cord-319163-d1oj15cw	106	7	for	for	IN
cord-319163-d1oj15cw	106	8	more	more	JJR
cord-319163-d1oj15cw	106	9	than	than	IN
cord-319163-d1oj15cw	106	10	12	12	CD
cord-319163-d1oj15cw	106	11	wk	wk	NNS
cord-319163-d1oj15cw	106	12	(	(	-LRB-
cord-319163-d1oj15cw	106	13	61	61	CD
cord-319163-d1oj15cw	106	14	)	)	-RRB-
cord-319163-d1oj15cw	106	15	.	.	.
cord-319163-d1oj15cw	107	1	It	-PRON-	PRP
cord-319163-d1oj15cw	107	2	is	be	VBZ
cord-319163-d1oj15cw	107	3	commonly	commonly	RB
cord-319163-d1oj15cw	107	4	categorized	categorize	VBN
cord-319163-d1oj15cw	107	5	into	into	IN
cord-319163-d1oj15cw	107	6	2	2	CD
cord-319163-d1oj15cw	107	7	groups	group	NNS
cord-319163-d1oj15cw	107	8	based	base	VBN
cord-319163-d1oj15cw	107	9	on	on	IN
cord-319163-d1oj15cw	107	10	the	the	DT
cord-319163-d1oj15cw	107	11	presence	presence	NN
cord-319163-d1oj15cw	107	12	or	or	CC
cord-319163-d1oj15cw	107	13	absence	absence	NN
cord-319163-d1oj15cw	107	14	of	of	IN
cord-319163-d1oj15cw	107	15	nasal	nasal	NN
cord-319163-d1oj15cw	107	16	polyps	polyp	NNS
cord-319163-d1oj15cw	107	17	(	(	-LRB-
cord-319163-d1oj15cw	107	18	NPs	NPs	NNP
cord-319163-d1oj15cw	107	19	)	)	-RRB-
cord-319163-d1oj15cw	107	20	:	:	:
cord-319163-d1oj15cw	107	21	chronic	chronic	JJ
cord-319163-d1oj15cw	107	22	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	107	23	with	with	IN
cord-319163-d1oj15cw	107	24	nasal	nasal	NN
cord-319163-d1oj15cw	107	25	polyps	polyp	NNS
cord-319163-d1oj15cw	107	26	(	(	-LRB-
cord-319163-d1oj15cw	107	27	CRSwNP	crswnp	NN
cord-319163-d1oj15cw	107	28	)	)	-RRB-
cord-319163-d1oj15cw	107	29	and	and	CC
cord-319163-d1oj15cw	107	30	chronic	chronic	JJ
cord-319163-d1oj15cw	107	31	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	107	32	without	without	IN
cord-319163-d1oj15cw	107	33	nasal	nasal	NN
cord-319163-d1oj15cw	107	34	polyps	polyp	NNS
cord-319163-d1oj15cw	107	35	(	(	-LRB-
cord-319163-d1oj15cw	107	36	CRSsNP	crssnp	NN
cord-319163-d1oj15cw	107	37	)	)	-RRB-
cord-319163-d1oj15cw	107	38	(	(	-LRB-
cord-319163-d1oj15cw	107	39	62	62	CD
cord-319163-d1oj15cw	107	40	)	)	-RRB-
cord-319163-d1oj15cw	107	41	.	.	.
cord-319163-d1oj15cw	108	1	The	the	DT
cord-319163-d1oj15cw	108	2	2	2	CD
cord-319163-d1oj15cw	108	3	groups	group	NNS
cord-319163-d1oj15cw	108	4	show	show	VBP
cord-319163-d1oj15cw	108	5	distinct	distinct	JJ
cord-319163-d1oj15cw	108	6	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	108	7	patterns	pattern	NNS
cord-319163-d1oj15cw	108	8	.	.	.
cord-319163-d1oj15cw	109	1	Whereas	whereas	IN
cord-319163-d1oj15cw	109	2	CRSsNP	CRSsNP	NNP
cord-319163-d1oj15cw	109	3	is	be	VBZ
cord-319163-d1oj15cw	109	4	characterized	characterize	VBN
cord-319163-d1oj15cw	109	5	by	by	IN
cord-319163-d1oj15cw	109	6	type	type	NN
cord-319163-d1oj15cw	109	7	1	1	CD
cord-319163-d1oj15cw	109	8	inflammation	inflammation	NN
cord-319163-d1oj15cw	109	9	with	with	IN
cord-319163-d1oj15cw	109	10	increased	increase	VBN
cord-319163-d1oj15cw	109	11	levels	level	NNS
cord-319163-d1oj15cw	109	12	of	of	IN
cord-319163-d1oj15cw	109	13	IFN	IFN	NNP
cord-319163-d1oj15cw	109	14	-	-	HYPH
cord-319163-d1oj15cw	109	15	γ	γ	NNP
cord-319163-d1oj15cw	109	16	in	in	IN
cord-319163-d1oj15cw	109	17	the	the	DT
cord-319163-d1oj15cw	109	18	inflamed	inflamed	JJ
cord-319163-d1oj15cw	109	19	sinus	sinus	NN
cord-319163-d1oj15cw	109	20	mucosa	mucosa	NN
cord-319163-d1oj15cw	109	21	and	and	CC
cord-319163-d1oj15cw	109	22	low	low	JJ
cord-319163-d1oj15cw	109	23	ECP	ECP	NNP
cord-319163-d1oj15cw	109	24	/	/	SYM
cord-319163-d1oj15cw	109	25	myeloperoxidase	myeloperoxidase	NN
cord-319163-d1oj15cw	109	26	ratios	ratio	NNS
cord-319163-d1oj15cw	109	27	,	,	,
cord-319163-d1oj15cw	109	28	CRSwNP	CRSwNP	NNP
cord-319163-d1oj15cw	109	29	is	be	VBZ
cord-319163-d1oj15cw	109	30	typically	typically	RB
cord-319163-d1oj15cw	109	31	characterized	characterize	VBN
cord-319163-d1oj15cw	109	32	by	by	IN
cord-319163-d1oj15cw	109	33	type	type	NN
cord-319163-d1oj15cw	109	34	2	2	CD
cord-319163-d1oj15cw	109	35	inflammation	inflammation	NN
cord-319163-d1oj15cw	109	36	,	,	,
cord-319163-d1oj15cw	109	37	which	which	WDT
cord-319163-d1oj15cw	109	38	is	be	VBZ
cord-319163-d1oj15cw	109	39	associated	associate	VBN
cord-319163-d1oj15cw	109	40	with	with	IN
cord-319163-d1oj15cw	109	41	a	a	DT
cord-319163-d1oj15cw	109	42	typical	typical	JJ
cord-319163-d1oj15cw	109	43	Th2-skewed	th2-skewed	JJ
cord-319163-d1oj15cw	109	44	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	109	45	inflammation	inflammation	NN
cord-319163-d1oj15cw	109	46	with	with	IN
cord-319163-d1oj15cw	109	47	high	high	JJ
cord-319163-d1oj15cw	109	48	IL-5	IL-5	NNP
cord-319163-d1oj15cw	109	49	and	and	CC
cord-319163-d1oj15cw	109	50	ECP	ECP	NNP
cord-319163-d1oj15cw	109	51	concentrations	concentration	NNS
cord-319163-d1oj15cw	109	52	in	in	IN
cord-319163-d1oj15cw	109	53	the	the	DT
cord-319163-d1oj15cw	109	54	polyps	polyp	NNS
cord-319163-d1oj15cw	109	55	(	(	-LRB-
cord-319163-d1oj15cw	109	56	63	63	CD
cord-319163-d1oj15cw	109	57	,	,	,
cord-319163-d1oj15cw	109	58	64	64	CD
cord-319163-d1oj15cw	109	59	)	)	-RRB-
cord-319163-d1oj15cw	109	60	.	.	.
cord-319163-d1oj15cw	110	1	IL-5	IL-5	NNP
cord-319163-d1oj15cw	110	2	is	be	VBZ
cord-319163-d1oj15cw	110	3	a	a	DT
cord-319163-d1oj15cw	110	4	potent	potent	JJ
cord-319163-d1oj15cw	110	5	activator	activator	NN
cord-319163-d1oj15cw	110	6	and	and	CC
cord-319163-d1oj15cw	110	7	survival	survival	NN
cord-319163-d1oj15cw	110	8	factor	factor	NN
cord-319163-d1oj15cw	110	9	for	for	IN
cord-319163-d1oj15cw	110	10	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	110	11	.	.	.
cord-319163-d1oj15cw	111	1	Several	several	JJ
cord-319163-d1oj15cw	111	2	reports	report	NNS
cord-319163-d1oj15cw	111	3	show	show	VBP
cord-319163-d1oj15cw	111	4	that	that	IN
cord-319163-d1oj15cw	111	5	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	111	6	inflammation	inflammation	NN
cord-319163-d1oj15cw	111	7	is	be	VBZ
cord-319163-d1oj15cw	111	8	dominant	dominant	JJ
cord-319163-d1oj15cw	111	9	in	in	IN
cord-319163-d1oj15cw	111	10	patients	patient	NNS
cord-319163-d1oj15cw	111	11	with	with	IN
cord-319163-d1oj15cw	111	12	severe	severe	JJ
cord-319163-d1oj15cw	111	13	refractory	refractory	JJ
cord-319163-d1oj15cw	111	14	CRS	CRS	NNP
cord-319163-d1oj15cw	111	15	(	(	-LRB-
cord-319163-d1oj15cw	111	16	65	65	CD
cord-319163-d1oj15cw	111	17	,	,	,
cord-319163-d1oj15cw	111	18	66	66	CD
cord-319163-d1oj15cw	111	19	)	)	-RRB-
cord-319163-d1oj15cw	111	20	.	.	.
cord-319163-d1oj15cw	112	1	However	however	RB
cord-319163-d1oj15cw	112	2	,	,	,
cord-319163-d1oj15cw	112	3	recent	recent	JJ
cord-319163-d1oj15cw	112	4	findings	finding	NNS
cord-319163-d1oj15cw	112	5	in	in	IN
cord-319163-d1oj15cw	112	6	Eastern	Eastern	NNP
cord-319163-d1oj15cw	112	7	Asia	Asia	NNP
cord-319163-d1oj15cw	112	8	countries	country	NNS
cord-319163-d1oj15cw	112	9	showed	show	VBD
cord-319163-d1oj15cw	112	10	that	that	IN
cord-319163-d1oj15cw	112	11	CRSwNP	crswnp	NN
cord-319163-d1oj15cw	112	12	can	can	MD
cord-319163-d1oj15cw	112	13	be	be	VB
cord-319163-d1oj15cw	112	14	classified	classify	VBN
cord-319163-d1oj15cw	112	15	into	into	IN
cord-319163-d1oj15cw	112	16	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	112	17	and	and	CC
cord-319163-d1oj15cw	112	18	non	non	JJ
cord-319163-d1oj15cw	112	19	-	-	JJ
cord-319163-d1oj15cw	112	20	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	112	21	type	type	NN
cord-319163-d1oj15cw	112	22	(	(	-LRB-
cord-319163-d1oj15cw	112	23	67	67	CD
cord-319163-d1oj15cw	112	24	)	)	-RRB-
cord-319163-d1oj15cw	112	25	.	.	.
cord-319163-d1oj15cw	113	1	NP	NP	NNP
cord-319163-d1oj15cw	113	2	from	from	IN
cord-319163-d1oj15cw	113	3	Caucasian	caucasian	JJ
cord-319163-d1oj15cw	113	4	patients	patient	NNS
cord-319163-d1oj15cw	113	5	are	be	VBP
cord-319163-d1oj15cw	113	6	mainly	mainly	RB
cord-319163-d1oj15cw	113	7	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	113	8	-	-	HYPH
cord-319163-d1oj15cw	113	9	dominant	dominant	JJ
cord-319163-d1oj15cw	113	10	with	with	IN
cord-319163-d1oj15cw	113	11	robust	robust	JJ
cord-319163-d1oj15cw	113	12	Th2	th2	CD
cord-319163-d1oj15cw	113	13	response	response	NN
cord-319163-d1oj15cw	113	14	(	(	-LRB-
cord-319163-d1oj15cw	113	15	>	>	NFP
cord-319163-d1oj15cw	113	16	80	80	CD
cord-319163-d1oj15cw	113	17	%	%	NN
cord-319163-d1oj15cw	113	18	)	)	-RRB-
cord-319163-d1oj15cw	113	19	,	,	,
cord-319163-d1oj15cw	113	20	whereas	whereas	IN
cord-319163-d1oj15cw	113	21	NP	NP	NNP
cord-319163-d1oj15cw	113	22	from	from	IN
cord-319163-d1oj15cw	113	23	Asian	asian	JJ
cord-319163-d1oj15cw	113	24	patients	patient	NNS
cord-319163-d1oj15cw	113	25	(	(	-LRB-
cord-319163-d1oj15cw	113	26	Korea	Korea	NNP
cord-319163-d1oj15cw	113	27	,	,	,
cord-319163-d1oj15cw	113	28	Japan	Japan	NNP
cord-319163-d1oj15cw	113	29	,	,	,
cord-319163-d1oj15cw	113	30	and	and	CC
cord-319163-d1oj15cw	113	31	China	China	NNP
cord-319163-d1oj15cw	113	32	)	)	-RRB-
cord-319163-d1oj15cw	113	33	are	be	VBP
cord-319163-d1oj15cw	113	34	characterized	characterize	VBN
cord-319163-d1oj15cw	113	35	by	by	IN
cord-319163-d1oj15cw	113	36	less	less	JJR
cord-319163-d1oj15cw	113	37	infiltration	infiltration	NN
cord-319163-d1oj15cw	113	38	of	of	IN
cord-319163-d1oj15cw	113	39	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	113	40	but	but	CC
cord-319163-d1oj15cw	113	41	are	be	VBP
cord-319163-d1oj15cw	113	42	largely	largely	RB
cord-319163-d1oj15cw	113	43	neutrophil	neutrophil	NN
cord-319163-d1oj15cw	113	44	-	-	HYPH
cord-319163-d1oj15cw	113	45	dominant	dominant	JJ
cord-319163-d1oj15cw	113	46	(	(	-LRB-
cord-319163-d1oj15cw	113	47	>	>	NFP
cord-319163-d1oj15cw	113	48	50	50	CD
cord-319163-d1oj15cw	113	49	%	%	NN
cord-319163-d1oj15cw	113	50	)	)	-RRB-
cord-319163-d1oj15cw	113	51	with	with	IN
cord-319163-d1oj15cw	113	52	mixed	mixed	JJ
cord-319163-d1oj15cw	113	53	Th1	th1	NN
cord-319163-d1oj15cw	113	54	or	or	CC
cord-319163-d1oj15cw	113	55	Th17	th17	CD
cord-319163-d1oj15cw	113	56	type	type	NN
cord-319163-d1oj15cw	113	57	inflammation	inflammation	NN
cord-319163-d1oj15cw	113	58	(	(	-LRB-
cord-319163-d1oj15cw	113	59	68	68	CD
cord-319163-d1oj15cw	113	60	)	)	-RRB-
cord-319163-d1oj15cw	113	61	(	(	-LRB-
cord-319163-d1oj15cw	113	62	69	69	CD
cord-319163-d1oj15cw	113	63	)	)	-RRB-
cord-319163-d1oj15cw	113	64	(	(	-LRB-
cord-319163-d1oj15cw	113	65	70	70	CD
cord-319163-d1oj15cw	113	66	)	)	-RRB-
cord-319163-d1oj15cw	113	67	(	(	-LRB-
cord-319163-d1oj15cw	113	68	71	71	CD
cord-319163-d1oj15cw	113	69	)	)	-RRB-
cord-319163-d1oj15cw	113	70	(	(	-LRB-
cord-319163-d1oj15cw	113	71	72	72	CD
cord-319163-d1oj15cw	113	72	)	)	-RRB-
cord-319163-d1oj15cw	113	73	.	.	.
cord-319163-d1oj15cw	114	1	Of	of	IN
cord-319163-d1oj15cw	114	2	interest	interest	NN
cord-319163-d1oj15cw	114	3	,	,	,
cord-319163-d1oj15cw	114	4	NP	NP	NNP
cord-319163-d1oj15cw	114	5	from	from	IN
cord-319163-d1oj15cw	114	6	Asian	asian	JJ
cord-319163-d1oj15cw	114	7	patients	patient	NNS
cord-319163-d1oj15cw	114	8	born	bear	VBN
cord-319163-d1oj15cw	114	9	and	and	CC
cord-319163-d1oj15cw	114	10	resided	reside	VBD
cord-319163-d1oj15cw	114	11	in	in	IN
cord-319163-d1oj15cw	114	12	the	the	DT
cord-319163-d1oj15cw	114	13	United	United	NNP
cord-319163-d1oj15cw	114	14	States	States	NNP
cord-319163-d1oj15cw	114	15	appears	appear	VBZ
cord-319163-d1oj15cw	114	16	non	non	JJ
cord-319163-d1oj15cw	114	17	-	-	JJ
cord-319163-d1oj15cw	114	18	eosiniphil	eosiniphil	JJ
cord-319163-d1oj15cw	114	19	-	-	HYPH
cord-319163-d1oj15cw	114	20	dominant	dominant	JJ
cord-319163-d1oj15cw	114	21	,	,	,
cord-319163-d1oj15cw	114	22	suggesting	suggest	VBG
cord-319163-d1oj15cw	114	23	the	the	DT
cord-319163-d1oj15cw	114	24	contribution	contribution	NN
cord-319163-d1oj15cw	114	25	of	of	IN
cord-319163-d1oj15cw	114	26	genetic	genetic	JJ
cord-319163-d1oj15cw	114	27	factors	factor	NNS
cord-319163-d1oj15cw	114	28	to	to	IN
cord-319163-d1oj15cw	114	29	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	114	30	inflammation	inflammation	NN
cord-319163-d1oj15cw	114	31	in	in	IN
cord-319163-d1oj15cw	114	32	NP	NP	NNP
cord-319163-d1oj15cw	114	33	(	(	-LRB-
cord-319163-d1oj15cw	114	34	73	73	CD
cord-319163-d1oj15cw	114	35	)	)	-RRB-
cord-319163-d1oj15cw	114	36	.	.	.
cord-319163-d1oj15cw	115	1	Another	another	DT
cord-319163-d1oj15cw	115	2	core	core	NN
cord-319163-d1oj15cw	115	3	pathologic	pathologic	JJ
cord-319163-d1oj15cw	115	4	feature	feature	NN
cord-319163-d1oj15cw	115	5	of	of	IN
cord-319163-d1oj15cw	115	6	CRS	CRS	NNP
cord-319163-d1oj15cw	115	7	is	be	VBZ
cord-319163-d1oj15cw	115	8	elevated	elevate	VBN
cord-319163-d1oj15cw	115	9	prostaglandin	prostaglandin	NN
cord-319163-d1oj15cw	115	10	D	d	NN
cord-319163-d1oj15cw	115	11	2	2	CD
cord-319163-d1oj15cw	115	12	(	(	-LRB-
cord-319163-d1oj15cw	115	13	PGD	PGD	NNP
cord-319163-d1oj15cw	115	14	2	2	CD
cord-319163-d1oj15cw	115	15	)	)	-RRB-
cord-319163-d1oj15cw	115	16	levels	level	NNS
cord-319163-d1oj15cw	115	17	.	.	.
cord-319163-d1oj15cw	116	1	Upregulation	Upregulation	NNP
cord-319163-d1oj15cw	116	2	of	of	IN
cord-319163-d1oj15cw	116	3	PGD	PGD	NNP
cord-319163-d1oj15cw	116	4	2	2	CD
cord-319163-d1oj15cw	116	5	in	in	IN
cord-319163-d1oj15cw	116	6	NPs	NPs	NNP
cord-319163-d1oj15cw	116	7	correlates	correlate	VBZ
cord-319163-d1oj15cw	116	8	strongly	strongly	RB
cord-319163-d1oj15cw	116	9	with	with	IN
cord-319163-d1oj15cw	116	10	the	the	DT
cord-319163-d1oj15cw	116	11	number	number	NN
cord-319163-d1oj15cw	116	12	of	of	IN
cord-319163-d1oj15cw	116	13	mast	mast	NN
cord-319163-d1oj15cw	116	14	cells	cell	NNS
cord-319163-d1oj15cw	116	15	that	that	WDT
cord-319163-d1oj15cw	116	16	mainly	mainly	RB
cord-319163-d1oj15cw	116	17	produce	produce	VBP
cord-319163-d1oj15cw	116	18	PGD	PGD	NNP
cord-319163-d1oj15cw	116	19	2	2	CD
cord-319163-d1oj15cw	116	20	and	and	CC
cord-319163-d1oj15cw	116	21	play	play	VB
cord-319163-d1oj15cw	116	22	an	an	DT
cord-319163-d1oj15cw	116	23	important	important	JJ
cord-319163-d1oj15cw	116	24	role	role	NN
cord-319163-d1oj15cw	116	25	in	in	IN
cord-319163-d1oj15cw	116	26	orchestrating	orchestrate	VBG
cord-319163-d1oj15cw	116	27	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	116	28	infiltration	infiltration	NN
cord-319163-d1oj15cw	116	29	in	in	IN
cord-319163-d1oj15cw	116	30	patients	patient	NNS
cord-319163-d1oj15cw	116	31	with	with	IN
cord-319163-d1oj15cw	116	32	CRS	CRS	NNP
cord-319163-d1oj15cw	116	33	(	(	-LRB-
cord-319163-d1oj15cw	116	34	74	74	CD
cord-319163-d1oj15cw	116	35	)	)	-RRB-
cord-319163-d1oj15cw	116	36	(	(	-LRB-
cord-319163-d1oj15cw	116	37	75	75	CD
cord-319163-d1oj15cw	116	38	)	)	-RRB-
cord-319163-d1oj15cw	116	39	(	(	-LRB-
cord-319163-d1oj15cw	116	40	76	76	CD
cord-319163-d1oj15cw	116	41	)	)	-RRB-
cord-319163-d1oj15cw	116	42	.	.	.
cord-319163-d1oj15cw	117	1	Also	also	RB
cord-319163-d1oj15cw	117	2	,	,	,
cord-319163-d1oj15cw	117	3	expression	expression	NN
cord-319163-d1oj15cw	117	4	of	of	IN
cord-319163-d1oj15cw	117	5	PGD	PGD	NNP
cord-319163-d1oj15cw	117	6	2	2	CD
cord-319163-d1oj15cw	117	7	synthase	synthase	NN
cord-319163-d1oj15cw	117	8	is	be	VBZ
cord-319163-d1oj15cw	117	9	increased	increase	VBN
cord-319163-d1oj15cw	117	10	in	in	IN
cord-319163-d1oj15cw	117	11	patients	patient	NNS
cord-319163-d1oj15cw	117	12	with	with	IN
cord-319163-d1oj15cw	117	13	CRSwNP	crswnp	NN
cord-319163-d1oj15cw	117	14	and	and	CC
cord-319163-d1oj15cw	117	15	correlates	correlate	VBZ
cord-319163-d1oj15cw	117	16	positively	positively	RB
cord-319163-d1oj15cw	117	17	with	with	IN
cord-319163-d1oj15cw	117	18	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	117	19	inflammation	inflammation	NN
cord-319163-d1oj15cw	117	20	(	(	-LRB-
cord-319163-d1oj15cw	117	21	77	77	CD
cord-319163-d1oj15cw	117	22	)	)	-RRB-
cord-319163-d1oj15cw	117	23	.	.	.
cord-319163-d1oj15cw	118	1	However	however	RB
cord-319163-d1oj15cw	118	2	,	,	,
cord-319163-d1oj15cw	118	3	it	-PRON-	PRP
cord-319163-d1oj15cw	118	4	is	be	VBZ
cord-319163-d1oj15cw	118	5	unclear	unclear	JJ
cord-319163-d1oj15cw	118	6	why	why	WRB
cord-319163-d1oj15cw	118	7	these	these	DT
cord-319163-d1oj15cw	118	8	pathologic	pathologic	JJ
cord-319163-d1oj15cw	118	9	features	feature	NNS
cord-319163-d1oj15cw	118	10	occur	occur	VBP
cord-319163-d1oj15cw	118	11	in	in	IN
cord-319163-d1oj15cw	118	12	CRS	CRS	NNP
cord-319163-d1oj15cw	118	13	.	.	.
cord-319163-d1oj15cw	119	1	Previous	previous	JJ
cord-319163-d1oj15cw	119	2	reports	report	NNS
cord-319163-d1oj15cw	119	3	suggest	suggest	VBP
cord-319163-d1oj15cw	119	4	that	that	IN
cord-319163-d1oj15cw	119	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	119	6	plays	play	VBZ
cord-319163-d1oj15cw	119	7	an	an	DT
cord-319163-d1oj15cw	119	8	important	important	JJ
cord-319163-d1oj15cw	119	9	role	role	NN
cord-319163-d1oj15cw	119	10	in	in	IN
cord-319163-d1oj15cw	119	11	CRS	CRS	NNP
cord-319163-d1oj15cw	119	12	(	(	-LRB-
cord-319163-d1oj15cw	119	13	Table	table	NN
cord-319163-d1oj15cw	119	14	1	1	CD
cord-319163-d1oj15cw	119	15	)	)	-RRB-
cord-319163-d1oj15cw	119	16	(	(	-LRB-
cord-319163-d1oj15cw	119	17	15,16	15,16	CD
cord-319163-d1oj15cw	119	18	)	)	-RRB-
cord-319163-d1oj15cw	119	19	.	.	.
cord-319163-d1oj15cw	120	1	Chen	Chen	NNP
cord-319163-d1oj15cw	120	2	et	et	NNP
cord-319163-d1oj15cw	120	3	al	al	NNP
cord-319163-d1oj15cw	120	4	.	.	.
cord-319163-d1oj15cw	121	1	(	(	-LRB-
cord-319163-d1oj15cw	121	2	15	15	CD
cord-319163-d1oj15cw	121	3	)	)	-RRB-
cord-319163-d1oj15cw	121	4	showed	show	VBD
cord-319163-d1oj15cw	121	5	that	that	IN
cord-319163-d1oj15cw	121	6	expression	expression	NN
cord-319163-d1oj15cw	121	7	of	of	IN
cord-319163-d1oj15cw	121	8	LC3	LC3	NNP
cord-319163-d1oj15cw	121	9	protein	protein	NN
cord-319163-d1oj15cw	121	10	fell	fall	VBD
cord-319163-d1oj15cw	121	11	markedly	markedly	RB
cord-319163-d1oj15cw	121	12	,	,	,
cord-319163-d1oj15cw	121	13	but	but	CC
cord-319163-d1oj15cw	121	14	Akt	Akt	NNP
cord-319163-d1oj15cw	121	15	/	/	SYM
cord-319163-d1oj15cw	121	16	mTOR	mTOR	NNP
cord-319163-d1oj15cw	121	17	signaling	signal	VBG
cord-319163-d1oj15cw	121	18	(	(	-LRB-
cord-319163-d1oj15cw	121	19	a	a	DT
cord-319163-d1oj15cw	121	20	negative	negative	JJ
cord-319163-d1oj15cw	121	21	regulator	regulator	NN
cord-319163-d1oj15cw	121	22	of	of	IN
cord-319163-d1oj15cw	121	23	autophagy	autophagy	NN
cord-319163-d1oj15cw	121	24	)	)	-RRB-
cord-319163-d1oj15cw	121	25	was	be	VBD
cord-319163-d1oj15cw	121	26	activated	activate	VBN
cord-319163-d1oj15cw	121	27	,	,	,
cord-319163-d1oj15cw	121	28	in	in	IN
cord-319163-d1oj15cw	121	29	NPs	NPs	NNPS
cord-319163-d1oj15cw	121	30	from	from	IN
cord-319163-d1oj15cw	121	31	patients	patient	NNS
cord-319163-d1oj15cw	121	32	with	with	IN
cord-319163-d1oj15cw	121	33	CRSwNP	crswnp	NN
cord-319163-d1oj15cw	121	34	but	but	CC
cord-319163-d1oj15cw	121	35	not	not	RB
cord-319163-d1oj15cw	121	36	in	in	IN
cord-319163-d1oj15cw	121	37	individuals	individual	NNS
cord-319163-d1oj15cw	121	38	with	with	IN
cord-319163-d1oj15cw	121	39	normal	normal	JJ
cord-319163-d1oj15cw	121	40	nasal	nasal	NN
cord-319163-d1oj15cw	121	41	mucosa	mucosa	JJ
cord-319163-d1oj15cw	121	42	.	.	.
cord-319163-d1oj15cw	122	1	In	in	IN
cord-319163-d1oj15cw	122	2	addition	addition	NN
cord-319163-d1oj15cw	122	3	,	,	,
cord-319163-d1oj15cw	122	4	they	-PRON-	PRP
cord-319163-d1oj15cw	122	5	demonstrated	demonstrate	VBD
cord-319163-d1oj15cw	122	6	a	a	DT
cord-319163-d1oj15cw	122	7	negative	negative	JJ
cord-319163-d1oj15cw	122	8	correlation	correlation	NN
cord-319163-d1oj15cw	122	9	between	between	IN
cord-319163-d1oj15cw	122	10	autophagy	autophagy	NN
cord-319163-d1oj15cw	122	11	and	and	CC
cord-319163-d1oj15cw	122	12	NPs	np	NNS
cord-319163-d1oj15cw	122	13	;	;	:
cord-319163-d1oj15cw	122	14	also	also	RB
cord-319163-d1oj15cw	122	15	,	,	,
cord-319163-d1oj15cw	122	16	formation	formation	NN
cord-319163-d1oj15cw	122	17	of	of	IN
cord-319163-d1oj15cw	122	18	LC3	LC3	NNP
cord-319163-d1oj15cw	122	19	puncta	puncta	NN
cord-319163-d1oj15cw	122	20	(	(	-LRB-
cord-319163-d1oj15cw	122	21	an	an	DT
cord-319163-d1oj15cw	122	22	alternative	alternative	JJ
cord-319163-d1oj15cw	122	23	indicator	indicator	NN
cord-319163-d1oj15cw	122	24	of	of	IN
cord-319163-d1oj15cw	122	25	autophagy	autophagy	NN
cord-319163-d1oj15cw	122	26	)	)	-RRB-
cord-319163-d1oj15cw	122	27	decreased	decrease	VBD
cord-319163-d1oj15cw	122	28	in	in	IN
cord-319163-d1oj15cw	122	29	NP	NP	NNP
cord-319163-d1oj15cw	122	30	-	-	HYPH
cord-319163-d1oj15cw	122	31	derived	derive	VBN
cord-319163-d1oj15cw	122	32	fibroblasts	fibroblast	NNS
cord-319163-d1oj15cw	122	33	(	(	-LRB-
cord-319163-d1oj15cw	122	34	15	15	CD
cord-319163-d1oj15cw	122	35	)	)	-RRB-
cord-319163-d1oj15cw	122	36	.	.	.
cord-319163-d1oj15cw	123	1	In	in	IN
cord-319163-d1oj15cw	123	2	another	another	DT
cord-319163-d1oj15cw	123	3	report	report	NN
cord-319163-d1oj15cw	123	4	,	,	,
cord-319163-d1oj15cw	123	5	Wang	Wang	NNP
cord-319163-d1oj15cw	123	6	et	et	NNP
cord-319163-d1oj15cw	123	7	al	al	NNP
cord-319163-d1oj15cw	123	8	.	.	.
cord-319163-d1oj15cw	124	1	(	(	-LRB-
cord-319163-d1oj15cw	124	2	16	16	CD
cord-319163-d1oj15cw	124	3	)	)	-RRB-
cord-319163-d1oj15cw	124	4	showed	show	VBD
cord-319163-d1oj15cw	124	5	that	that	IN
cord-319163-d1oj15cw	124	6	NP	NP	NNP
cord-319163-d1oj15cw	124	7	tissues	tissue	NNS
cord-319163-d1oj15cw	124	8	are	be	VBP
cord-319163-d1oj15cw	124	9	deficient	deficient	JJ
cord-319163-d1oj15cw	124	10	in	in	IN
cord-319163-d1oj15cw	124	11	autophagy	autophagy	NN
cord-319163-d1oj15cw	124	12	and	and	CC
cord-319163-d1oj15cw	124	13	that	that	IN
cord-319163-d1oj15cw	124	14	cyclooxygenase	cyclooxygenase	NN
cord-319163-d1oj15cw	124	15	2	2	CD
cord-319163-d1oj15cw	124	16	(	(	-LRB-
cord-319163-d1oj15cw	124	17	COX-2	COX-2	NNP
cord-319163-d1oj15cw	124	18	)	)	-RRB-
cord-319163-d1oj15cw	124	19	is	be	VBZ
cord-319163-d1oj15cw	124	20	negatively	negatively	RB
cord-319163-d1oj15cw	124	21	regulated	regulate	VBN
cord-319163-d1oj15cw	124	22	by	by	IN
cord-319163-d1oj15cw	124	23	autophagy	autophagy	NN
cord-319163-d1oj15cw	124	24	in	in	IN
cord-319163-d1oj15cw	124	25	NP	NP	NNP
cord-319163-d1oj15cw	124	26	-	-	HYPH
cord-319163-d1oj15cw	124	27	derived	derive	VBN
cord-319163-d1oj15cw	124	28	fibroblasts	fibroblast	NNS
cord-319163-d1oj15cw	124	29	.	.	.
cord-319163-d1oj15cw	125	1	LC3	LC3	NNP
cord-319163-d1oj15cw	125	2	and	and	CC
cord-319163-d1oj15cw	125	3	COX-2	COX-2	NNP
cord-319163-d1oj15cw	125	4	(	(	-LRB-
cord-319163-d1oj15cw	125	5	a	a	DT
cord-319163-d1oj15cw	125	6	common	common	JJ
cord-319163-d1oj15cw	125	7	indicator	indicator	NN
cord-319163-d1oj15cw	125	8	of	of	IN
cord-319163-d1oj15cw	125	9	inflammation	inflammation	NN
cord-319163-d1oj15cw	125	10	)	)	-RRB-
cord-319163-d1oj15cw	125	11	were	be	VBD
cord-319163-d1oj15cw	125	12	analyzed	analyze	VBN
cord-319163-d1oj15cw	125	13	by	by	IN
cord-319163-d1oj15cw	125	14	immunoblotting	immunoblotte	VBG
cord-319163-d1oj15cw	125	15	in	in	IN
cord-319163-d1oj15cw	125	16	fresh	fresh	JJ
cord-319163-d1oj15cw	125	17	tissues	tissue	NNS
cord-319163-d1oj15cw	125	18	from	from	IN
cord-319163-d1oj15cw	125	19	NPs	NPs	NNP
cord-319163-d1oj15cw	125	20	and	and	CC
cord-319163-d1oj15cw	125	21	control	control	NN
cord-319163-d1oj15cw	125	22	nasal	nasal	NN
cord-319163-d1oj15cw	125	23	mucosa	mucosa	JJ
cord-319163-d1oj15cw	125	24	.	.	.
cord-319163-d1oj15cw	126	1	LC3	lc3	JJ
cord-319163-d1oj15cw	126	2	expression	expression	NN
cord-319163-d1oj15cw	126	3	was	be	VBD
cord-319163-d1oj15cw	126	4	decreased	decrease	VBN
cord-319163-d1oj15cw	126	5	,	,	,
cord-319163-d1oj15cw	126	6	while	while	IN
cord-319163-d1oj15cw	126	7	COX-2	cox-2	JJ
cord-319163-d1oj15cw	126	8	expression	expression	NN
cord-319163-d1oj15cw	126	9	increased	increase	VBD
cord-319163-d1oj15cw	126	10	significantly	significantly	RB
cord-319163-d1oj15cw	126	11	,	,	,
cord-319163-d1oj15cw	126	12	in	in	IN
cord-319163-d1oj15cw	126	13	fresh	fresh	JJ
cord-319163-d1oj15cw	126	14	NP	NP	NNP
cord-319163-d1oj15cw	126	15	tissues	tissue	NNS
cord-319163-d1oj15cw	126	16	compared	compare	VBN
cord-319163-d1oj15cw	126	17	with	with	IN
cord-319163-d1oj15cw	126	18	control	control	NN
cord-319163-d1oj15cw	126	19	nasal	nasal	NN
cord-319163-d1oj15cw	126	20	mucosa	mucosa	JJ
cord-319163-d1oj15cw	126	21	(	(	-LRB-
cord-319163-d1oj15cw	126	22	16	16	CD
cord-319163-d1oj15cw	126	23	)	)	-RRB-
cord-319163-d1oj15cw	126	24	.	.	.
cord-319163-d1oj15cw	127	1	In	in	IN
cord-319163-d1oj15cw	127	2	addition	addition	NN
cord-319163-d1oj15cw	127	3	,	,	,
cord-319163-d1oj15cw	127	4	COX-2	cox-2	JJ
cord-319163-d1oj15cw	127	5	expression	expression	NN
cord-319163-d1oj15cw	127	6	by	by	IN
cord-319163-d1oj15cw	127	7	NP	NP	NNP
cord-319163-d1oj15cw	127	8	-	-	HYPH
cord-319163-d1oj15cw	127	9	derived	derive	VBN
cord-319163-d1oj15cw	127	10	fibroblasts	fibroblast	NNS
cord-319163-d1oj15cw	127	11	and	and	CC
cord-319163-d1oj15cw	127	12	nasal	nasal	JJ
cord-319163-d1oj15cw	127	13	mucosa	mucosa	RB
cord-319163-d1oj15cw	127	14	-	-	HYPH
cord-319163-d1oj15cw	127	15	derived	derive	VBN
cord-319163-d1oj15cw	127	16	fibroblasts	fibroblast	NNS
cord-319163-d1oj15cw	127	17	was	be	VBD
cord-319163-d1oj15cw	127	18	reduced	reduce	VBN
cord-319163-d1oj15cw	127	19	by	by	IN
cord-319163-d1oj15cw	127	20	starvation	starvation	NN
cord-319163-d1oj15cw	127	21	-	-	HYPH
cord-319163-d1oj15cw	127	22	induced	induce	VBN
cord-319163-d1oj15cw	127	23	autophagy	autophagy	NN
cord-319163-d1oj15cw	127	24	and	and	CC
cord-319163-d1oj15cw	127	25	by	by	IN
cord-319163-d1oj15cw	127	26	overexpression	overexpression	NN
cord-319163-d1oj15cw	127	27	of	of	IN
cord-319163-d1oj15cw	127	28	LC3	LC3	NNP
cord-319163-d1oj15cw	127	29	;	;	:
cord-319163-d1oj15cw	127	30	however	however	RB
cord-319163-d1oj15cw	127	31	,	,	,
cord-319163-d1oj15cw	127	32	it	-PRON-	PRP
cord-319163-d1oj15cw	127	33	increased	increase	VBD
cord-319163-d1oj15cw	127	34	upon	upon	IN
cord-319163-d1oj15cw	127	35	inhibition	inhibition	NN
cord-319163-d1oj15cw	127	36	of	of	IN
cord-319163-d1oj15cw	127	37	autophagy	autophagy	NN
cord-319163-d1oj15cw	127	38	by	by	IN
cord-319163-d1oj15cw	127	39	3-MA	3-ma	CD
cord-319163-d1oj15cw	127	40	(	(	-LRB-
cord-319163-d1oj15cw	127	41	16	16	CD
cord-319163-d1oj15cw	127	42	)	)	-RRB-
cord-319163-d1oj15cw	127	43	.	.	.
cord-319163-d1oj15cw	128	1	Choi	Choi	NNP
cord-319163-d1oj15cw	128	2	et	et	NNP
cord-319163-d1oj15cw	128	3	al	al	NNP
cord-319163-d1oj15cw	128	4	.	.	.
cord-319163-d1oj15cw	129	1	(	(	-LRB-
cord-319163-d1oj15cw	129	2	17	17	CD
cord-319163-d1oj15cw	129	3	)	)	-RRB-
cord-319163-d1oj15cw	129	4	used	use	VBD
cord-319163-d1oj15cw	129	5	a	a	DT
cord-319163-d1oj15cw	129	6	murine	murine	JJ
cord-319163-d1oj15cw	129	7	model	model	NN
cord-319163-d1oj15cw	129	8	of	of	IN
cord-319163-d1oj15cw	129	9	CRS	CRS	NNP
cord-319163-d1oj15cw	129	10	(	(	-LRB-
cord-319163-d1oj15cw	129	11	mice	mouse	NNS
cord-319163-d1oj15cw	129	12	in	in	IN
cord-319163-d1oj15cw	129	13	which	which	WDT
cord-319163-d1oj15cw	129	14	Atg7	Atg7	NNP
cord-319163-d1oj15cw	129	15	is	be	VBZ
cord-319163-d1oj15cw	129	16	conditionally	conditionally	RB
cord-319163-d1oj15cw	129	17	deleted	delete	VBN
cord-319163-d1oj15cw	129	18	in	in	IN
cord-319163-d1oj15cw	129	19	a	a	DT
cord-319163-d1oj15cw	129	20	myeloid	myeloid	JJ
cord-319163-d1oj15cw	129	21	cell	cell	NN
cord-319163-d1oj15cw	129	22	-	-	HYPH
cord-319163-d1oj15cw	129	23	specific	specific	JJ
cord-319163-d1oj15cw	129	24	manner	manner	NN
cord-319163-d1oj15cw	129	25	)	)	-RRB-
cord-319163-d1oj15cw	129	26	to	to	TO
cord-319163-d1oj15cw	129	27	show	show	VB
cord-319163-d1oj15cw	129	28	that	that	IN
cord-319163-d1oj15cw	129	29	disruption	disruption	NN
cord-319163-d1oj15cw	129	30	of	of	IN
cord-319163-d1oj15cw	129	31	autophagy	autophagy	NN
cord-319163-d1oj15cw	129	32	in	in	IN
cord-319163-d1oj15cw	129	33	CRS	CRS	NNP
cord-319163-d1oj15cw	129	34	is	be	VBZ
cord-319163-d1oj15cw	129	35	linked	link	VBN
cord-319163-d1oj15cw	129	36	to	to	IN
cord-319163-d1oj15cw	129	37	dysregulation	dysregulation	NN
cord-319163-d1oj15cw	129	38	of	of	IN
cord-319163-d1oj15cw	129	39	PGD	PGD	NNP
cord-319163-d1oj15cw	129	40	2	2	CD
cord-319163-d1oj15cw	129	41	production	production	NN
cord-319163-d1oj15cw	129	42	and	and	CC
cord-319163-d1oj15cw	129	43	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	129	44	inflammation	inflammation	NN
cord-319163-d1oj15cw	129	45	(	(	-LRB-
cord-319163-d1oj15cw	129	46	Table	table	NN
cord-319163-d1oj15cw	129	47	1	1	CD
cord-319163-d1oj15cw	129	48	)	)	-RRB-
cord-319163-d1oj15cw	129	49	.	.	.
cord-319163-d1oj15cw	130	1	Indeed	indeed	RB
cord-319163-d1oj15cw	130	2	,	,	,
cord-319163-d1oj15cw	130	3	more	more	RBR
cord-319163-d1oj15cw	130	4	severe	severe	JJ
cord-319163-d1oj15cw	130	5	exacerbation	exacerbation	NN
cord-319163-d1oj15cw	130	6	of	of	IN
cord-319163-d1oj15cw	130	7	CRS	CRS	NNP
cord-319163-d1oj15cw	130	8	was	be	VBD
cord-319163-d1oj15cw	130	9	induced	induce	VBN
cord-319163-d1oj15cw	130	10	in	in	IN
cord-319163-d1oj15cw	130	11	myeloid	myeloid	JJ
cord-319163-d1oj15cw	130	12	cell	cell	NN
cord-319163-d1oj15cw	130	13	-	-	HYPH
cord-319163-d1oj15cw	130	14	specific	specific	JJ
cord-319163-d1oj15cw	130	15	Atg7-deficient	atg7-deficient	JJ
cord-319163-d1oj15cw	130	16	mice	mouse	NNS
cord-319163-d1oj15cw	130	17	than	than	IN
cord-319163-d1oj15cw	130	18	in	in	IN
cord-319163-d1oj15cw	130	19	wild	wild	JJ
cord-319163-d1oj15cw	130	20	-	-	HYPH
cord-319163-d1oj15cw	130	21	type	type	NN
cord-319163-d1oj15cw	130	22	mice	mouse	NNS
cord-319163-d1oj15cw	130	23	with	with	IN
cord-319163-d1oj15cw	130	24	increased	increase	VBN
cord-319163-d1oj15cw	130	25	infiltration	infiltration	NN
cord-319163-d1oj15cw	130	26	of	of	IN
cord-319163-d1oj15cw	130	27	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	130	28	and	and	CC
cord-319163-d1oj15cw	130	29	production	production	NN
cord-319163-d1oj15cw	130	30	of	of	IN
cord-319163-d1oj15cw	130	31	PGD	PGD	NNP
cord-319163-d1oj15cw	130	32	2	2	CD
cord-319163-d1oj15cw	130	33	(	(	-LRB-
cord-319163-d1oj15cw	130	34	17	17	CD
cord-319163-d1oj15cw	130	35	)	)	-RRB-
cord-319163-d1oj15cw	130	36	.	.	.
cord-319163-d1oj15cw	131	1	In	in	IN
cord-319163-d1oj15cw	131	2	addition	addition	NN
cord-319163-d1oj15cw	131	3	,	,	,
cord-319163-d1oj15cw	131	4	depletion	depletion	NN
cord-319163-d1oj15cw	131	5	of	of	IN
cord-319163-d1oj15cw	131	6	autophagy	autophagy	NN
cord-319163-d1oj15cw	131	7	-	-	HYPH
cord-319163-d1oj15cw	131	8	deficient	deficient	JJ
cord-319163-d1oj15cw	131	9	macrophages	macrophage	NNS
cord-319163-d1oj15cw	131	10	alleviated	alleviate	VBD
cord-319163-d1oj15cw	131	11	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	131	12	inflammation	inflammation	NN
cord-319163-d1oj15cw	131	13	and	and	CC
cord-319163-d1oj15cw	131	14	PGD	PGD	NNP
cord-319163-d1oj15cw	131	15	2	2	CD
cord-319163-d1oj15cw	131	16	dysregulation	dysregulation	NN
cord-319163-d1oj15cw	131	17	significantly	significantly	RB
cord-319163-d1oj15cw	131	18	(	(	-LRB-
cord-319163-d1oj15cw	131	19	17	17	CD
cord-319163-d1oj15cw	131	20	)	)	-RRB-
cord-319163-d1oj15cw	131	21	.	.	.
cord-319163-d1oj15cw	132	1	These	these	DT
cord-319163-d1oj15cw	132	2	findings	finding	NNS
cord-319163-d1oj15cw	132	3	suggest	suggest	VBP
cord-319163-d1oj15cw	132	4	a	a	DT
cord-319163-d1oj15cw	132	5	critical	critical	JJ
cord-319163-d1oj15cw	132	6	role	role	NN
cord-319163-d1oj15cw	132	7	of	of	IN
cord-319163-d1oj15cw	132	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	132	9	in	in	IN
cord-319163-d1oj15cw	132	10	exacerbating	exacerbate	VBG
cord-319163-d1oj15cw	132	11	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	132	12	inflammation	inflammation	NN
cord-319163-d1oj15cw	132	13	and	and	CC
cord-319163-d1oj15cw	132	14	in	in	IN
cord-319163-d1oj15cw	132	15	the	the	DT
cord-319163-d1oj15cw	132	16	pathologic	pathologic	JJ
cord-319163-d1oj15cw	132	17	features	feature	NNS
cord-319163-d1oj15cw	132	18	associated	associate	VBN
cord-319163-d1oj15cw	132	19	with	with	IN
cord-319163-d1oj15cw	132	20	CRS	CRS	NNP
cord-319163-d1oj15cw	132	21	.	.	.
cord-319163-d1oj15cw	133	1	Also	also	RB
cord-319163-d1oj15cw	133	2	,	,	,
cord-319163-d1oj15cw	133	3	it	-PRON-	PRP
cord-319163-d1oj15cw	133	4	suggests	suggest	VBZ
cord-319163-d1oj15cw	133	5	the	the	DT
cord-319163-d1oj15cw	133	6	possibility	possibility	NN
cord-319163-d1oj15cw	133	7	that	that	IN
cord-319163-d1oj15cw	133	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	133	9	may	may	MD
cord-319163-d1oj15cw	133	10	be	be	VB
cord-319163-d1oj15cw	133	11	a	a	DT
cord-319163-d1oj15cw	133	12	valuable	valuable	JJ
cord-319163-d1oj15cw	133	13	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	133	14	target	target	NN
cord-319163-d1oj15cw	133	15	for	for	IN
cord-319163-d1oj15cw	133	16	resolution	resolution	NN
cord-319163-d1oj15cw	133	17	of	of	IN
cord-319163-d1oj15cw	133	18	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	133	19	inflammation	inflammation	NN
cord-319163-d1oj15cw	133	20	in	in	IN
cord-319163-d1oj15cw	133	21	CRS	CRS	NNP
cord-319163-d1oj15cw	133	22	.	.	.
cord-319163-d1oj15cw	134	1	Undoubtedly	undoubtedly	RB
cord-319163-d1oj15cw	134	2	,	,	,
cord-319163-d1oj15cw	134	3	the	the	DT
cord-319163-d1oj15cw	134	4	role	role	NN
cord-319163-d1oj15cw	134	5	of	of	IN
cord-319163-d1oj15cw	134	6	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	134	7	in	in	IN
cord-319163-d1oj15cw	134	8	airway	airway	NN
cord-319163-d1oj15cw	134	9	inflammation	inflammation	NN
cord-319163-d1oj15cw	134	10	is	be	VBZ
cord-319163-d1oj15cw	134	11	important	important	JJ
cord-319163-d1oj15cw	134	12	.	.	.
cord-319163-d1oj15cw	135	1	Here	here	RB
cord-319163-d1oj15cw	135	2	,	,	,
cord-319163-d1oj15cw	135	3	we	-PRON-	PRP
cord-319163-d1oj15cw	135	4	describe	describe	VBP
cord-319163-d1oj15cw	135	5	the	the	DT
cord-319163-d1oj15cw	135	6	importance	importance	NN
cord-319163-d1oj15cw	135	7	of	of	IN
cord-319163-d1oj15cw	135	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	135	9	in	in	IN
cord-319163-d1oj15cw	135	10	asthma	asthma	NN
cord-319163-d1oj15cw	135	11	,	,	,
cord-319163-d1oj15cw	135	12	COPD	COPD	NNP
cord-319163-d1oj15cw	135	13	,	,	,
cord-319163-d1oj15cw	135	14	and	and	CC
cord-319163-d1oj15cw	135	15	CRS	CRS	NNP
cord-319163-d1oj15cw	135	16	,	,	,
cord-319163-d1oj15cw	135	17	focusing	focus	VBG
cord-319163-d1oj15cw	135	18	on	on	IN
cord-319163-d1oj15cw	135	19	eosinophil	eosinophil	RB
cord-319163-d1oj15cw	135	20	-	-	HYPH
cord-319163-d1oj15cw	135	21	mediated	mediate	VBN
cord-319163-d1oj15cw	135	22	airway	airway	NN
cord-319163-d1oj15cw	135	23	inflammations	inflammation	NNS
cord-319163-d1oj15cw	135	24	.	.	.
cord-319163-d1oj15cw	136	1	SNP	SNP	NNP
cord-319163-d1oj15cw	136	2	rs12212740	rs12212740	NNP
cord-319163-d1oj15cw	136	3	G	g	NN
cord-319163-d1oj15cw	136	4	>	>	XX
cord-319163-d1oj15cw	137	1	A	a	DT
cord-319163-d1oj15cw	137	2	of	of	IN
cord-319163-d1oj15cw	137	3	Atg5	Atg5	NNP
cord-319163-d1oj15cw	137	4	correlates	correlate	VBZ
cord-319163-d1oj15cw	137	5	significantly	significantly	RB
cord-319163-d1oj15cw	137	6	with	with	IN
cord-319163-d1oj15cw	137	7	loss	loss	NN
cord-319163-d1oj15cw	137	8	of	of	IN
cord-319163-d1oj15cw	137	9	pre	pre	JJ
cord-319163-d1oj15cw	137	10	-	-	JJ
cord-319163-d1oj15cw	137	11	bronchodilator	bronchodilator	JJ
cord-319163-d1oj15cw	137	12	FEV1	FEV1	NNP
cord-319163-d1oj15cw	137	13	in	in	IN
cord-319163-d1oj15cw	137	14	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	137	15	patients	patient	NNS
cord-319163-d1oj15cw	137	16	.	.	.
cord-319163-d1oj15cw	138	1	Inhibition	inhibition	NN
cord-319163-d1oj15cw	138	2	of	of	IN
cord-319163-d1oj15cw	138	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	138	4	in	in	IN
cord-319163-d1oj15cw	138	5	a	a	DT
cord-319163-d1oj15cw	138	6	murine	murine	JJ
cord-319163-d1oj15cw	138	7	asthma	asthma	NN
cord-319163-d1oj15cw	138	8	model	model	NN
cord-319163-d1oj15cw	138	9	improves	improve	VBZ
cord-319163-d1oj15cw	138	10	AHR	AHR	NNP
cord-319163-d1oj15cw	138	11	,	,	,
cord-319163-d1oj15cw	138	12	reduces	reduce	VBZ
cord-319163-d1oj15cw	138	13	the	the	DT
cord-319163-d1oj15cw	138	14	number	number	NN
cord-319163-d1oj15cw	138	15	of	of	IN
cord-319163-d1oj15cw	138	16	infiltrating	infiltrate	VBG
cord-319163-d1oj15cw	138	17	eosinophils	eosinophils	NN
cord-319163-d1oj15cw	138	18	,	,	,
cord-319163-d1oj15cw	138	19	and	and	CC
cord-319163-d1oj15cw	138	20	reduces	reduce	VBZ
cord-319163-d1oj15cw	138	21	IL-5	IL-5	NNP
cord-319163-d1oj15cw	138	22	levels	level	NNS
cord-319163-d1oj15cw	138	23	in	in	IN
cord-319163-d1oj15cw	138	24	bronchoalveolar	bronchoalveolar	NNP
cord-319163-d1oj15cw	138	25	lavage	lavage	NN
cord-319163-d1oj15cw	138	26	fluid	fluid	NN
cord-319163-d1oj15cw	138	27	.	.	.
cord-319163-d1oj15cw	139	1	In	in	IN
cord-319163-d1oj15cw	139	2	addition	addition	NN
cord-319163-d1oj15cw	139	3	,	,	,
cord-319163-d1oj15cw	139	4	autophagy	autophagy	NN
cord-319163-d1oj15cw	139	5	is	be	VBZ
cord-319163-d1oj15cw	139	6	a	a	DT
cord-319163-d1oj15cw	139	7	potential	potential	JJ
cord-319163-d1oj15cw	139	8	link	link	NN
cord-319163-d1oj15cw	139	9	between	between	IN
cord-319163-d1oj15cw	139	10	virus	virus	NN
cord-319163-d1oj15cw	139	11	infection	infection	NN
cord-319163-d1oj15cw	139	12	and	and	CC
cord-319163-d1oj15cw	139	13	asthma	asthma	NN
cord-319163-d1oj15cw	139	14	.	.	.
cord-319163-d1oj15cw	140	1	However	however	RB
cord-319163-d1oj15cw	140	2	,	,	,
cord-319163-d1oj15cw	140	3	deficiency	deficiency	NN
cord-319163-d1oj15cw	140	4	of	of	IN
cord-319163-d1oj15cw	140	5	CD11c	CD11c	NNP
cord-319163-d1oj15cw	140	6	-	-	HYPH
cord-319163-d1oj15cw	140	7	specific	specific	JJ
cord-319163-d1oj15cw	140	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	140	9	promotes	promote	VBZ
cord-319163-d1oj15cw	140	10	neutrophilic	neutrophilic	JJ
cord-319163-d1oj15cw	140	11	inflammation	inflammation	NN
cord-319163-d1oj15cw	140	12	in	in	IN
cord-319163-d1oj15cw	140	13	a	a	DT
cord-319163-d1oj15cw	140	14	murine	murine	JJ
cord-319163-d1oj15cw	140	15	asthma	asthma	NN
cord-319163-d1oj15cw	140	16	model	model	NN
cord-319163-d1oj15cw	140	17	.	.	.
cord-319163-d1oj15cw	141	1	These	these	DT
cord-319163-d1oj15cw	141	2	results	result	NNS
cord-319163-d1oj15cw	141	3	suggest	suggest	VBP
cord-319163-d1oj15cw	141	4	that	that	IN
cord-319163-d1oj15cw	141	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	141	6	plays	play	VBZ
cord-319163-d1oj15cw	141	7	different	different	JJ
cord-319163-d1oj15cw	141	8	roles	role	NNS
cord-319163-d1oj15cw	141	9	depending	depend	VBG
cord-319163-d1oj15cw	141	10	on	on	IN
cord-319163-d1oj15cw	141	11	the	the	DT
cord-319163-d1oj15cw	141	12	cell	cell	NN
cord-319163-d1oj15cw	141	13	type	type	NN
cord-319163-d1oj15cw	141	14	and/or	and/or	CC
cord-319163-d1oj15cw	141	15	the	the	DT
cord-319163-d1oj15cw	141	16	disease	disease	NN
cord-319163-d1oj15cw	141	17	model	model	NN
cord-319163-d1oj15cw	141	18	employed	employ	VBN
cord-319163-d1oj15cw	141	19	.	.	.
cord-319163-d1oj15cw	142	1	Thus	thus	RB
cord-319163-d1oj15cw	142	2	,	,	,
cord-319163-d1oj15cw	142	3	further	further	JJ
cord-319163-d1oj15cw	142	4	studies	study	NNS
cord-319163-d1oj15cw	142	5	are	be	VBP
cord-319163-d1oj15cw	142	6	necessary	necessary	JJ
cord-319163-d1oj15cw	142	7	if	if	IN
cord-319163-d1oj15cw	142	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	142	9	is	be	VBZ
cord-319163-d1oj15cw	142	10	to	to	TO
cord-319163-d1oj15cw	142	11	be	be	VB
cord-319163-d1oj15cw	142	12	targeted	target	VBN
cord-319163-d1oj15cw	142	13	successfully	successfully	RB
cord-319163-d1oj15cw	142	14	to	to	TO
cord-319163-d1oj15cw	142	15	treat	treat	VB
cord-319163-d1oj15cw	142	16	asthma	asthma	NN
cord-319163-d1oj15cw	142	17	.	.	.
cord-319163-d1oj15cw	143	1	With	with	IN
cord-319163-d1oj15cw	143	2	respect	respect	NN
cord-319163-d1oj15cw	143	3	to	to	IN
cord-319163-d1oj15cw	143	4	COPD	COPD	NNP
cord-319163-d1oj15cw	143	5	,	,	,
cord-319163-d1oj15cw	143	6	autophagy	autophagy	NN
cord-319163-d1oj15cw	143	7	is	be	VBZ
cord-319163-d1oj15cw	143	8	an	an	DT
cord-319163-d1oj15cw	143	9	important	important	JJ
cord-319163-d1oj15cw	143	10	regulator	regulator	NN
cord-319163-d1oj15cw	143	11	of	of	IN
cord-319163-d1oj15cw	143	12	epithelial	epithelial	JJ
cord-319163-d1oj15cw	143	13	cell	cell	NN
cord-319163-d1oj15cw	143	14	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	143	15	,	,	,
cord-319163-d1oj15cw	143	16	which	which	WDT
cord-319163-d1oj15cw	143	17	contributes	contribute	VBZ
cord-319163-d1oj15cw	143	18	to	to	IN
cord-319163-d1oj15cw	143	19	the	the	DT
cord-319163-d1oj15cw	143	20	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	143	21	of	of	IN
cord-319163-d1oj15cw	143	22	COPD	COPD	NNP
cord-319163-d1oj15cw	143	23	.	.	.
cord-319163-d1oj15cw	144	1	CS	CS	NNP
cord-319163-d1oj15cw	144	2	extract	extract	NN
cord-319163-d1oj15cw	144	3	induces	induce	VBZ
cord-319163-d1oj15cw	144	4	not	not	RB
cord-319163-d1oj15cw	144	5	only	only	RB
cord-319163-d1oj15cw	144	6	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	144	7	pathway	pathway	NN
cord-319163-d1oj15cw	144	8	,	,	,
cord-319163-d1oj15cw	144	9	e.g.	e.g.	RB
cord-319163-d1oj15cw	144	10	,	,	,
cord-319163-d1oj15cw	144	11	DISC	DISC	NNP
cord-319163-d1oj15cw	144	12	and	and	CC
cord-319163-d1oj15cw	144	13	caspase-8	caspase-8	NNP
cord-319163-d1oj15cw	144	14	,	,	,
cord-319163-d1oj15cw	144	15	but	but	CC
cord-319163-d1oj15cw	144	16	also	also	RB
cord-319163-d1oj15cw	144	17	activates	activate	VBZ
cord-319163-d1oj15cw	144	18	LC3B	lc3b	NN
cord-319163-d1oj15cw	144	19	,	,	,
cord-319163-d1oj15cw	144	20	autophagosome	autophagosome	JJ
cord-319163-d1oj15cw	144	21	formation	formation	NN
cord-319163-d1oj15cw	144	22	and	and	CC
cord-319163-d1oj15cw	144	23	,	,	,
cord-319163-d1oj15cw	144	24	eventually	eventually	RB
cord-319163-d1oj15cw	144	25	,	,	,
cord-319163-d1oj15cw	144	26	caspase-3	caspase-3	NNP
cord-319163-d1oj15cw	144	27	in	in	IN
cord-319163-d1oj15cw	144	28	epithelial	epithelial	JJ
cord-319163-d1oj15cw	144	29	cells	cell	NNS
cord-319163-d1oj15cw	144	30	.	.	.
cord-319163-d1oj15cw	145	1	These	these	DT
cord-319163-d1oj15cw	145	2	pathways	pathway	NNS
cord-319163-d1oj15cw	145	3	are	be	VBP
cord-319163-d1oj15cw	145	4	inhibited	inhibit	VBN
cord-319163-d1oj15cw	145	5	either	either	CC
cord-319163-d1oj15cw	145	6	by	by	IN
cord-319163-d1oj15cw	145	7	siRNAmediated	sirnamediated	JJ
cord-319163-d1oj15cw	145	8	knockdown	knockdown	NN
cord-319163-d1oj15cw	145	9	of	of	IN
cord-319163-d1oj15cw	145	10	Beclin-1	Beclin-1	NNP
cord-319163-d1oj15cw	145	11	or	or	CC
cord-319163-d1oj15cw	145	12	LC3B	lc3b	NN
cord-319163-d1oj15cw	145	13	,	,	,
cord-319163-d1oj15cw	145	14	or	or	CC
cord-319163-d1oj15cw	145	15	by	by	IN
cord-319163-d1oj15cw	145	16	an	an	DT
cord-319163-d1oj15cw	145	17	inhibitor	inhibitor	NN
cord-319163-d1oj15cw	145	18	of	of	IN
cord-319163-d1oj15cw	145	19	autophagy	autophagy	NN
cord-319163-d1oj15cw	145	20	such	such	JJ
cord-319163-d1oj15cw	145	21	as	as	IN
cord-319163-d1oj15cw	145	22	3-MA	3-ma	CD
cord-319163-d1oj15cw	145	23	.	.	.
cord-319163-d1oj15cw	146	1	Indeed	indeed	RB
cord-319163-d1oj15cw	146	2	,	,	,
cord-319163-d1oj15cw	146	3	autophagosome	autophagosome	JJ
cord-319163-d1oj15cw	146	4	formation	formation	NN
cord-319163-d1oj15cw	146	5	is	be	VBZ
cord-319163-d1oj15cw	146	6	higher	high	JJR
cord-319163-d1oj15cw	146	7	in	in	IN
cord-319163-d1oj15cw	146	8	COPD	COPD	NNP
cord-319163-d1oj15cw	146	9	patients	patient	NNS
cord-319163-d1oj15cw	146	10	than	than	IN
cord-319163-d1oj15cw	146	11	in	in	IN
cord-319163-d1oj15cw	146	12	healthy	healthy	JJ
cord-319163-d1oj15cw	146	13	controls	control	NNS
cord-319163-d1oj15cw	146	14	.	.	.
cord-319163-d1oj15cw	147	1	It	-PRON-	PRP
cord-319163-d1oj15cw	147	2	is	be	VBZ
cord-319163-d1oj15cw	147	3	suggested	suggest	VBN
cord-319163-d1oj15cw	147	4	that	that	IN
cord-319163-d1oj15cw	147	5	oxidative	oxidative	JJ
cord-319163-d1oj15cw	147	6	stress	stress	NN
cord-319163-d1oj15cw	147	7	is	be	VBZ
cord-319163-d1oj15cw	147	8	a	a	DT
cord-319163-d1oj15cw	147	9	critical	critical	JJ
cord-319163-d1oj15cw	147	10	mediator	mediator	NN
cord-319163-d1oj15cw	147	11	of	of	IN
cord-319163-d1oj15cw	147	12	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	147	13	in	in	IN
cord-319163-d1oj15cw	147	14	COPD	COPD	NNP
cord-319163-d1oj15cw	147	15	.	.	.
cord-319163-d1oj15cw	148	1	Exposure	exposure	NN
cord-319163-d1oj15cw	148	2	to	to	IN
cord-319163-d1oj15cw	148	3	CS	CS	NNP
cord-319163-d1oj15cw	148	4	induces	induce	VBZ
cord-319163-d1oj15cw	148	5	pro	pro	JJ
cord-319163-d1oj15cw	148	6	-	-	JJ
cord-319163-d1oj15cw	148	7	oxidant	oxidant	JJ
cord-319163-d1oj15cw	148	8	-	-	HYPH
cord-319163-d1oj15cw	148	9	mediated	mediate	VBN
cord-319163-d1oj15cw	148	10	stress	stress	NN
cord-319163-d1oj15cw	148	11	in	in	IN
cord-319163-d1oj15cw	148	12	epithelial	epithelial	JJ
cord-319163-d1oj15cw	148	13	cells	cell	NNS
cord-319163-d1oj15cw	148	14	.	.	.
cord-319163-d1oj15cw	149	1	Chemical	chemical	NN
cord-319163-d1oj15cw	149	2	inhibitors	inhibitor	NNS
cord-319163-d1oj15cw	149	3	of	of	IN
cord-319163-d1oj15cw	149	4	NADPH	NADPH	NNP
cord-319163-d1oj15cw	149	5	oxidase	oxidase	NN
cord-319163-d1oj15cw	149	6	,	,	,
cord-319163-d1oj15cw	149	7	a	a	DT
cord-319163-d1oj15cw	149	8	membrane	membrane	NN
cord-319163-d1oj15cw	149	9	-	-	HYPH
cord-319163-d1oj15cw	149	10	dependent	dependent	JJ
cord-319163-d1oj15cw	149	11	source	source	NN
cord-319163-d1oj15cw	149	12	of	of	IN
cord-319163-d1oj15cw	149	13	ROS	ROS	NNP
cord-319163-d1oj15cw	149	14	,	,	,
cord-319163-d1oj15cw	149	15	inhibit	inhibit	VB
cord-319163-d1oj15cw	149	16	CS	CS	NNP
cord-319163-d1oj15cw	149	17	extract	extract	NN
cord-319163-d1oj15cw	149	18	-	-	HYPH
cord-319163-d1oj15cw	149	19	induced	induce	VBN
cord-319163-d1oj15cw	149	20	activation	activation	NN
cord-319163-d1oj15cw	149	21	of	of	IN
cord-319163-d1oj15cw	149	22	LC3B	lc3b	NN
cord-319163-d1oj15cw	149	23	and	and	CC
cord-319163-d1oj15cw	149	24	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	149	25	.	.	.
cord-319163-d1oj15cw	150	1	These	these	DT
cord-319163-d1oj15cw	150	2	data	datum	NNS
cord-319163-d1oj15cw	150	3	implicate	implicate	VBP
cord-319163-d1oj15cw	150	4	autophagy	autophagy	NN
cord-319163-d1oj15cw	150	5	as	as	IN
cord-319163-d1oj15cw	150	6	an	an	DT
cord-319163-d1oj15cw	150	7	important	important	JJ
cord-319163-d1oj15cw	150	8	regulator	regulator	NN
cord-319163-d1oj15cw	150	9	of	of	IN
cord-319163-d1oj15cw	150	10	epithelial	epithelial	JJ
cord-319163-d1oj15cw	150	11	cell	cell	NN
cord-319163-d1oj15cw	150	12	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	150	13	and	and	CC
cord-319163-d1oj15cw	150	14	in	in	IN
cord-319163-d1oj15cw	150	15	the	the	DT
cord-319163-d1oj15cw	150	16	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	150	17	of	of	IN
cord-319163-d1oj15cw	150	18	CS	CS	NNP
cord-319163-d1oj15cw	150	19	-	-	HYPH
cord-319163-d1oj15cw	150	20	induced	induce	VBN
cord-319163-d1oj15cw	150	21	COPD	COPD	NNP
cord-319163-d1oj15cw	150	22	.	.	.
cord-319163-d1oj15cw	151	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	151	2	is	be	VBZ
cord-319163-d1oj15cw	151	3	also	also	RB
cord-319163-d1oj15cw	151	4	linked	link	VBN
cord-319163-d1oj15cw	151	5	to	to	IN
cord-319163-d1oj15cw	151	6	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	151	7	inflammation	inflammation	NN
cord-319163-d1oj15cw	151	8	in	in	IN
cord-319163-d1oj15cw	151	9	CRS	CRS	NNP
cord-319163-d1oj15cw	151	10	.	.	.
cord-319163-d1oj15cw	152	1	CRSwNP	CRSwNP	NNP
cord-319163-d1oj15cw	152	2	is	be	VBZ
cord-319163-d1oj15cw	152	3	associated	associate	VBN
cord-319163-d1oj15cw	152	4	with	with	IN
cord-319163-d1oj15cw	152	5	a	a	DT
cord-319163-d1oj15cw	152	6	typical	typical	JJ
cord-319163-d1oj15cw	152	7	Th2-skewed	th2-skewed	JJ
cord-319163-d1oj15cw	152	8	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	152	9	inflammation	inflammation	NN
cord-319163-d1oj15cw	152	10	,	,	,
cord-319163-d1oj15cw	152	11	with	with	IN
cord-319163-d1oj15cw	152	12	high	high	JJ
cord-319163-d1oj15cw	152	13	IL-5	IL-5	NNP
cord-319163-d1oj15cw	152	14	and	and	CC
cord-319163-d1oj15cw	152	15	ECP	ECP	NNP
cord-319163-d1oj15cw	152	16	levels	level	NNS
cord-319163-d1oj15cw	152	17	in	in	IN
cord-319163-d1oj15cw	152	18	NPs	NPs	NNP
cord-319163-d1oj15cw	152	19	.	.	.
cord-319163-d1oj15cw	153	1	Another	another	DT
cord-319163-d1oj15cw	153	2	core	core	NN
cord-319163-d1oj15cw	153	3	pathologic	pathologic	JJ
cord-319163-d1oj15cw	153	4	feature	feature	NN
cord-319163-d1oj15cw	153	5	of	of	IN
cord-319163-d1oj15cw	153	6	CRS	CRS	NNP
cord-319163-d1oj15cw	153	7	is	be	VBZ
cord-319163-d1oj15cw	153	8	increased	increase	VBN
cord-319163-d1oj15cw	153	9	expression	expression	NN
cord-319163-d1oj15cw	153	10	of	of	IN
cord-319163-d1oj15cw	153	11	PGD	PGD	NNP
cord-319163-d1oj15cw	153	12	2	2	CD
cord-319163-d1oj15cw	153	13	.	.	.
cord-319163-d1oj15cw	154	1	Upregulation	Upregulation	NNP
cord-319163-d1oj15cw	154	2	of	of	IN
cord-319163-d1oj15cw	154	3	PGD	PGD	NNP
cord-319163-d1oj15cw	154	4	2	2	CD
cord-319163-d1oj15cw	154	5	in	in	IN
cord-319163-d1oj15cw	154	6	NPs	NPs	NNP
cord-319163-d1oj15cw	154	7	correlates	correlate	VBZ
cord-319163-d1oj15cw	154	8	strongly	strongly	RB
cord-319163-d1oj15cw	154	9	with	with	IN
cord-319163-d1oj15cw	154	10	the	the	DT
cord-319163-d1oj15cw	154	11	number	number	NN
cord-319163-d1oj15cw	154	12	of	of	IN
cord-319163-d1oj15cw	154	13	mast	mast	NN
cord-319163-d1oj15cw	154	14	cells	cell	NNS
cord-319163-d1oj15cw	154	15	,	,	,
cord-319163-d1oj15cw	154	16	which	which	WDT
cord-319163-d1oj15cw	154	17	produce	produce	VBP
cord-319163-d1oj15cw	154	18	PGD	PGD	NNP
cord-319163-d1oj15cw	154	19	2	2	CD
cord-319163-d1oj15cw	154	20	and	and	CC
cord-319163-d1oj15cw	154	21	play	play	VB
cord-319163-d1oj15cw	154	22	an	an	DT
cord-319163-d1oj15cw	154	23	important	important	JJ
cord-319163-d1oj15cw	154	24	role	role	NN
cord-319163-d1oj15cw	154	25	in	in	IN
cord-319163-d1oj15cw	154	26	orchestrating	orchestrate	VBG
cord-319163-d1oj15cw	154	27	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	154	28	infiltration	infiltration	NN
cord-319163-d1oj15cw	154	29	in	in	IN
cord-319163-d1oj15cw	154	30	patients	patient	NNS
cord-319163-d1oj15cw	154	31	with	with	IN
cord-319163-d1oj15cw	154	32	CRS	CRS	NNP
cord-319163-d1oj15cw	154	33	.	.	.
cord-319163-d1oj15cw	155	1	Although	although	IN
cord-319163-d1oj15cw	155	2	it	-PRON-	PRP
cord-319163-d1oj15cw	155	3	is	be	VBZ
cord-319163-d1oj15cw	155	4	not	not	RB
cord-319163-d1oj15cw	155	5	clear	clear	JJ
cord-319163-d1oj15cw	155	6	how	how	WRB
cord-319163-d1oj15cw	155	7	these	these	DT
cord-319163-d1oj15cw	155	8	2	2	CD
cord-319163-d1oj15cw	155	9	factors	factor	NNS
cord-319163-d1oj15cw	155	10	are	be	VBP
cord-319163-d1oj15cw	155	11	linked	link	VBN
cord-319163-d1oj15cw	155	12	,	,	,
cord-319163-d1oj15cw	155	13	we	-PRON-	PRP
cord-319163-d1oj15cw	155	14	provide	provide	VBP
cord-319163-d1oj15cw	155	15	evidence	evidence	NN
cord-319163-d1oj15cw	155	16	that	that	IN
cord-319163-d1oj15cw	155	17	autophagy	autophagy	NN
cord-319163-d1oj15cw	155	18	is	be	VBZ
cord-319163-d1oj15cw	155	19	a	a	DT
cord-319163-d1oj15cw	155	20	key	key	JJ
cord-319163-d1oj15cw	155	21	mediator	mediator	NN
cord-319163-d1oj15cw	155	22	.	.	.
cord-319163-d1oj15cw	156	1	Observational	observational	JJ
cord-319163-d1oj15cw	156	2	studies	study	NNS
cord-319163-d1oj15cw	156	3	suggest	suggest	VBP
cord-319163-d1oj15cw	156	4	that	that	IN
cord-319163-d1oj15cw	156	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	156	6	is	be	VBZ
cord-319163-d1oj15cw	156	7	involved	involve	VBN
cord-319163-d1oj15cw	156	8	in	in	IN
cord-319163-d1oj15cw	156	9	CRS	CRS	NNP
cord-319163-d1oj15cw	156	10	.	.	.
cord-319163-d1oj15cw	157	1	For	for	IN
cord-319163-d1oj15cw	157	2	example	example	NN
cord-319163-d1oj15cw	157	3	,	,	,
cord-319163-d1oj15cw	157	4	expression	expression	NN
cord-319163-d1oj15cw	157	5	of	of	IN
cord-319163-d1oj15cw	157	6	LC3	lc3	JJ
cord-319163-d1oj15cw	157	7	protein	protein	NN
cord-319163-d1oj15cw	157	8	correlates	correlate	VBZ
cord-319163-d1oj15cw	157	9	negatively	negatively	RB
cord-319163-d1oj15cw	157	10	with	with	IN
cord-319163-d1oj15cw	157	11	NP	NP	NNP
cord-319163-d1oj15cw	157	12	development	development	NN
cord-319163-d1oj15cw	157	13	and	and	CC
cord-319163-d1oj15cw	157	14	expression	expression	NN
cord-319163-d1oj15cw	157	15	of	of	IN
cord-319163-d1oj15cw	157	16	COX-2	COX-2	NNP
cord-319163-d1oj15cw	157	17	.	.	.
cord-319163-d1oj15cw	158	1	In	in	IN
cord-319163-d1oj15cw	158	2	addition	addition	NN
cord-319163-d1oj15cw	158	3	,	,	,
cord-319163-d1oj15cw	158	4	increased	increase	VBN
cord-319163-d1oj15cw	158	5	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	158	6	inflammation	inflammation	NN
cord-319163-d1oj15cw	158	7	and	and	CC
cord-319163-d1oj15cw	158	8	PGD	PGD	NNP
cord-319163-d1oj15cw	158	9	2	2	CD
cord-319163-d1oj15cw	158	10	production	production	NN
cord-319163-d1oj15cw	158	11	induce	induce	VBP
cord-319163-d1oj15cw	158	12	more	more	RBR
cord-319163-d1oj15cw	158	13	severe	severe	JJ
cord-319163-d1oj15cw	158	14	CRS	CRS	NNP
cord-319163-d1oj15cw	158	15	in	in	IN
cord-319163-d1oj15cw	158	16	myeloid	myeloid	JJ
cord-319163-d1oj15cw	158	17	cell	cell	NN
cord-319163-d1oj15cw	158	18	-	-	HYPH
cord-319163-d1oj15cw	158	19	specific	specific	JJ
cord-319163-d1oj15cw	158	20	Atg7-deficient	atg7-deficient	JJ
cord-319163-d1oj15cw	158	21	mice	mouse	NNS
cord-319163-d1oj15cw	158	22	than	than	IN
cord-319163-d1oj15cw	158	23	in	in	IN
cord-319163-d1oj15cw	158	24	wild	wild	JJ
cord-319163-d1oj15cw	158	25	-	-	HYPH
cord-319163-d1oj15cw	158	26	type	type	NN
cord-319163-d1oj15cw	158	27	mice	mouse	NNS
cord-319163-d1oj15cw	158	28	.	.	.
cord-319163-d1oj15cw	159	1	These	these	DT
cord-319163-d1oj15cw	159	2	findings	finding	NNS
cord-319163-d1oj15cw	159	3	reveal	reveal	VBP
cord-319163-d1oj15cw	159	4	the	the	DT
cord-319163-d1oj15cw	159	5	critical	critical	JJ
cord-319163-d1oj15cw	159	6	role	role	NN
cord-319163-d1oj15cw	159	7	of	of	IN
cord-319163-d1oj15cw	159	8	autophagy	autophagy	NN
cord-319163-d1oj15cw	159	9	in	in	IN
cord-319163-d1oj15cw	159	10	exacerbating	exacerbate	VBG
cord-319163-d1oj15cw	159	11	CRS	CRS	NNP
cord-319163-d1oj15cw	159	12	.	.	.
cord-319163-d1oj15cw	160	1	Although	although	IN
cord-319163-d1oj15cw	160	2	autophagy	autophagy	NN
cord-319163-d1oj15cw	160	3	plays	play	VBZ
cord-319163-d1oj15cw	160	4	diverse	diverse	JJ
cord-319163-d1oj15cw	160	5	roles	role	NNS
cord-319163-d1oj15cw	160	6	,	,	,
cord-319163-d1oj15cw	160	7	either	either	CC
cord-319163-d1oj15cw	160	8	protective	protective	JJ
cord-319163-d1oj15cw	160	9	or	or	CC
cord-319163-d1oj15cw	160	10	detrimental	detrimental	JJ
cord-319163-d1oj15cw	160	11	,	,	,
cord-319163-d1oj15cw	160	12	in	in	IN
cord-319163-d1oj15cw	160	13	chronic	chronic	JJ
cord-319163-d1oj15cw	160	14	airway	airway	NN
cord-319163-d1oj15cw	160	15	inflammatory	inflammatory	NN
cord-319163-d1oj15cw	160	16	(	(	-LRB-
cord-319163-d1oj15cw	160	17	depending	depend	VBG
cord-319163-d1oj15cw	160	18	on	on	IN
cord-319163-d1oj15cw	160	19	the	the	DT
cord-319163-d1oj15cw	160	20	type	type	NN
cord-319163-d1oj15cw	160	21	of	of	IN
cord-319163-d1oj15cw	160	22	cell	cell	NN
cord-319163-d1oj15cw	160	23	affected	affect	VBN
cord-319163-d1oj15cw	160	24	and	and	CC
cord-319163-d1oj15cw	160	25	the	the	DT
cord-319163-d1oj15cw	160	26	disease	disease	NN
cord-319163-d1oj15cw	160	27	model	model	NN
cord-319163-d1oj15cw	160	28	used	use	VBN
cord-319163-d1oj15cw	160	29	)	)	-RRB-
cord-319163-d1oj15cw	160	30	,	,	,
cord-319163-d1oj15cw	160	31	it	-PRON-	PRP
cord-319163-d1oj15cw	160	32	holds	hold	VBZ
cord-319163-d1oj15cw	160	33	promise	promise	NN
cord-319163-d1oj15cw	160	34	as	as	IN
cord-319163-d1oj15cw	160	35	a	a	DT
cord-319163-d1oj15cw	160	36	novel	novel	JJ
cord-319163-d1oj15cw	160	37	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	160	38	target	target	NN
cord-319163-d1oj15cw	160	39	.	.	.
cord-319163-d1oj15cw	161	1	However	however	RB
cord-319163-d1oj15cw	161	2	,	,	,
cord-319163-d1oj15cw	161	3	the	the	DT
cord-319163-d1oj15cw	161	4	molecular	molecular	JJ
cord-319163-d1oj15cw	161	5	mechanism	mechanism	NN
cord-319163-d1oj15cw	161	6	underlying	underlie	VBG
cord-319163-d1oj15cw	161	7	disease	disease	NN
cord-319163-d1oj15cw	161	8	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	161	9	is	be	VBZ
cord-319163-d1oj15cw	161	10	not	not	RB
cord-319163-d1oj15cw	161	11	clear	clear	JJ
cord-319163-d1oj15cw	161	12	.	.	.
cord-319163-d1oj15cw	162	1	In	in	IN
cord-319163-d1oj15cw	162	2	addition	addition	NN
cord-319163-d1oj15cw	162	3	to	to	IN
cord-319163-d1oj15cw	162	4	its	-PRON-	PRP$
cord-319163-d1oj15cw	162	5	role	role	NN
cord-319163-d1oj15cw	162	6	in	in	IN
cord-319163-d1oj15cw	162	7	regulating	regulate	VBG
cord-319163-d1oj15cw	162	8	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	162	9	or	or	CC
cord-319163-d1oj15cw	162	10	neutrophilic	neutrophilic	JJ
cord-319163-d1oj15cw	162	11	inflammation	inflammation	NN
cord-319163-d1oj15cw	162	12	,	,	,
cord-319163-d1oj15cw	162	13	autophagy	autophagy	NN
cord-319163-d1oj15cw	162	14	has	have	VBZ
cord-319163-d1oj15cw	162	15	a	a	DT
cord-319163-d1oj15cw	162	16	broad	broad	JJ
cord-319163-d1oj15cw	162	17	effect	effect	NN
cord-319163-d1oj15cw	162	18	on	on	IN
cord-319163-d1oj15cw	162	19	diverse	diverse	JJ
cord-319163-d1oj15cw	162	20	Th	Th	NNP
cord-319163-d1oj15cw	162	21	responses	response	NNS
cord-319163-d1oj15cw	162	22	,	,	,
cord-319163-d1oj15cw	162	23	likely	likely	RB
cord-319163-d1oj15cw	162	24	by	by	IN
cord-319163-d1oj15cw	162	25	controlling	control	VBG
cord-319163-d1oj15cw	162	26	innate	innate	JJ
cord-319163-d1oj15cw	162	27	immune	immune	JJ
cord-319163-d1oj15cw	162	28	cells	cell	NNS
cord-319163-d1oj15cw	162	29	.	.	.
cord-319163-d1oj15cw	163	1	Autophagy	autophagy	JJ
cord-319163-d1oj15cw	163	2	-	-	HYPH
cord-319163-d1oj15cw	163	3	deficient	deficient	JJ
cord-319163-d1oj15cw	163	4	macrophages	macrophage	NNS
cord-319163-d1oj15cw	163	5	promote	promote	VBP
cord-319163-d1oj15cw	163	6	production	production	NN
cord-319163-d1oj15cw	163	7	of	of	IN
cord-319163-d1oj15cw	163	8	the	the	DT
cord-319163-d1oj15cw	163	9	Th1	th1	CD
cord-319163-d1oj15cw	163	10	cytokine	cytokine	NN
cord-319163-d1oj15cw	163	11	IFN	IFN	NNP
cord-319163-d1oj15cw	163	12	-	-	HYPH
cord-319163-d1oj15cw	163	13	γ	γ	NNP
cord-319163-d1oj15cw	163	14	during	during	IN
cord-319163-d1oj15cw	163	15	GalN	GalN	NNP
cord-319163-d1oj15cw	163	16	/	/	SYM
cord-319163-d1oj15cw	163	17	LPS	LPS	NNP
cord-319163-d1oj15cw	163	18	-	-	HYPH
cord-319163-d1oj15cw	163	19	induced	induce	VBN
cord-319163-d1oj15cw	163	20	liver	liver	NN
cord-319163-d1oj15cw	163	21	injury	injury	NN
cord-319163-d1oj15cw	163	22	(	(	-LRB-
cord-319163-d1oj15cw	163	23	78	78	CD
cord-319163-d1oj15cw	163	24	)	)	-RRB-
cord-319163-d1oj15cw	163	25	and	and	CC
cord-319163-d1oj15cw	163	26	dextran	dextran	NN
cord-319163-d1oj15cw	163	27	sulfate	sulfate	NN
cord-319163-d1oj15cw	163	28	sodiuminduced	sodiuminduce	VBN
cord-319163-d1oj15cw	163	29	colitis	colitis	NN
cord-319163-d1oj15cw	163	30	(	(	-LRB-
cord-319163-d1oj15cw	163	31	79	79	CD
cord-319163-d1oj15cw	163	32	)	)	-RRB-
cord-319163-d1oj15cw	163	33	.	.	.
cord-319163-d1oj15cw	164	1	Autophagy	autophagy	JJ
cord-319163-d1oj15cw	164	2	-	-	HYPH
cord-319163-d1oj15cw	164	3	deficient	deficient	JJ
cord-319163-d1oj15cw	164	4	myeloid	myeloid	NN
cord-319163-d1oj15cw	164	5	cells	cell	NNS
cord-319163-d1oj15cw	164	6	also	also	RB
cord-319163-d1oj15cw	164	7	promote	promote	VBP
cord-319163-d1oj15cw	164	8	Th17	th17	CD
cord-319163-d1oj15cw	164	9	responses	response	NNS
cord-319163-d1oj15cw	164	10	during	during	IN
cord-319163-d1oj15cw	164	11	Mycobacterium	Mycobacterium	NNP
cord-319163-d1oj15cw	164	12	tuberculosis	tuberculosis	NN
cord-319163-d1oj15cw	164	13	infection	infection	NN
cord-319163-d1oj15cw	164	14	(	(	-LRB-
cord-319163-d1oj15cw	164	15	80	80	CD
cord-319163-d1oj15cw	164	16	)	)	-RRB-
cord-319163-d1oj15cw	164	17	,	,	,
cord-319163-d1oj15cw	164	18	as	as	RB
cord-319163-d1oj15cw	164	19	well	well	RB
cord-319163-d1oj15cw	164	20	as	as	IN
cord-319163-d1oj15cw	164	21	Th2	Th2	NNP
cord-319163-d1oj15cw	164	22	responses	response	NNS
cord-319163-d1oj15cw	164	23	during	during	IN
cord-319163-d1oj15cw	164	24	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	164	25	CRS	CRS	NNP
cord-319163-d1oj15cw	164	26	(	(	-LRB-
cord-319163-d1oj15cw	164	27	17	17	CD
cord-319163-d1oj15cw	164	28	)	)	-RRB-
cord-319163-d1oj15cw	164	29	.	.	.
cord-319163-d1oj15cw	165	1	These	these	DT
cord-319163-d1oj15cw	165	2	results	result	NNS
cord-319163-d1oj15cw	165	3	suggest	suggest	VBP
cord-319163-d1oj15cw	165	4	that	that	IN
cord-319163-d1oj15cw	165	5	autophagy	autophagy	NN
cord-319163-d1oj15cw	165	6	is	be	VBZ
cord-319163-d1oj15cw	165	7	a	a	DT
cord-319163-d1oj15cw	165	8	versatile	versatile	JJ
cord-319163-d1oj15cw	165	9	immune	immune	JJ
cord-319163-d1oj15cw	165	10	modulator	modulator	NN
cord-319163-d1oj15cw	165	11	that	that	WDT
cord-319163-d1oj15cw	165	12	will	will	MD
cord-319163-d1oj15cw	165	13	require	require	VB
cord-319163-d1oj15cw	165	14	careful	careful	JJ
cord-319163-d1oj15cw	165	15	modulation	modulation	NN
cord-319163-d1oj15cw	165	16	to	to	TO
cord-319163-d1oj15cw	165	17	achieve	achieve	VB
cord-319163-d1oj15cw	165	18	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	165	19	benefit	benefit	NN
cord-319163-d1oj15cw	165	20	.	.	.
cord-319163-d1oj15cw	166	1	Thus	thus	RB
cord-319163-d1oj15cw	166	2	,	,	,
cord-319163-d1oj15cw	166	3	further	further	JJ
cord-319163-d1oj15cw	166	4	studies	study	NNS
cord-319163-d1oj15cw	166	5	are	be	VBP
cord-319163-d1oj15cw	166	6	needed	need	VBN
cord-319163-d1oj15cw	166	7	to	to	TO
cord-319163-d1oj15cw	166	8	demonstrate	demonstrate	VB
cord-319163-d1oj15cw	166	9	how	how	WRB
cord-319163-d1oj15cw	166	10	autophagy	autophagy	NN
cord-319163-d1oj15cw	166	11	contributes	contribute	VBZ
cord-319163-d1oj15cw	166	12	to	to	IN
cord-319163-d1oj15cw	166	13	the	the	DT
cord-319163-d1oj15cw	166	14	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	166	15	of	of	IN
cord-319163-d1oj15cw	166	16	various	various	JJ
cord-319163-d1oj15cw	166	17	airway	airway	JJ
cord-319163-d1oj15cw	166	18	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	166	19	diseases	disease	NNS
cord-319163-d1oj15cw	166	20	,	,	,
cord-319163-d1oj15cw	166	21	and	and	CC
cord-319163-d1oj15cw	166	22	to	to	TO
cord-319163-d1oj15cw	166	23	establish	establish	VB
cord-319163-d1oj15cw	166	24	an	an	DT
cord-319163-d1oj15cw	166	25	appropriate	appropriate	JJ
cord-319163-d1oj15cw	166	26	therapeutic	therapeutic	JJ
cord-319163-d1oj15cw	166	27	strategy	strategy	NN
cord-319163-d1oj15cw	166	28	dependent	dependent	JJ
cord-319163-d1oj15cw	166	29	of	of	IN
cord-319163-d1oj15cw	166	30	the	the	DT
cord-319163-d1oj15cw	166	31	unique	unique	JJ
cord-319163-d1oj15cw	166	32	context	context	NN
cord-319163-d1oj15cw	166	33	of	of	IN
cord-319163-d1oj15cw	166	34	different	different	JJ
cord-319163-d1oj15cw	166	35	diseases	disease	NNS
cord-319163-d1oj15cw	166	36	.	.	.
cord-319163-d1oj15cw	167	1	Autophagy	Autophagy	NNS
cord-319163-d1oj15cw	167	2	in	in	IN
cord-319163-d1oj15cw	167	3	immunity	immunity	NN
cord-319163-d1oj15cw	167	4	and	and	CC
cord-319163-d1oj15cw	167	5	inflammation	inflammation	NN
cord-319163-d1oj15cw	168	1	Why	why	WRB
cord-319163-d1oj15cw	168	2	is	be	VBZ
cord-319163-d1oj15cw	168	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	168	4	important	important	JJ
cord-319163-d1oj15cw	168	5	in	in	IN
cord-319163-d1oj15cw	168	6	human	human	JJ
cord-319163-d1oj15cw	168	7	diseases	disease	NNS
cord-319163-d1oj15cw	168	8	?	?	.
cord-319163-d1oj15cw	169	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	169	2	and	and	CC
cord-319163-d1oj15cw	169	3	inflammasomes	inflammasome	NNS
cord-319163-d1oj15cw	169	4	Mechanisms	Mechanisms	NNPS
cord-319163-d1oj15cw	169	5	and	and	CC
cord-319163-d1oj15cw	169	6	biological	biological	JJ
cord-319163-d1oj15cw	169	7	functions	function	NNS
cord-319163-d1oj15cw	169	8	of	of	IN
cord-319163-d1oj15cw	169	9	autophagy	autophagy	NN
cord-319163-d1oj15cw	169	10	in	in	IN
cord-319163-d1oj15cw	169	11	diseased	diseased	JJ
cord-319163-d1oj15cw	169	12	and	and	CC
cord-319163-d1oj15cw	169	13	ageing	age	VBG
cord-319163-d1oj15cw	169	14	kidneys	kidney	NNS
cord-319163-d1oj15cw	169	15	Autophagy	autophagy	NN
cord-319163-d1oj15cw	169	16	-	-	HYPH
cord-319163-d1oj15cw	169	17	associated	associate	VBN
cord-319163-d1oj15cw	169	18	immune	immune	JJ
cord-319163-d1oj15cw	169	19	responses	response	NNS
cord-319163-d1oj15cw	169	20	and	and	CC
cord-319163-d1oj15cw	169	21	cancer	cancer	NN
cord-319163-d1oj15cw	169	22	immunotherapy	immunotherapy	NN
cord-319163-d1oj15cw	169	23	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	169	24	in	in	IN
cord-319163-d1oj15cw	169	25	neurodegenerative	neurodegenerative	JJ
cord-319163-d1oj15cw	169	26	diseases	disease	NNS
cord-319163-d1oj15cw	170	1	Multistrain	Multistrain	NNP
cord-319163-d1oj15cw	170	2	probiotics	probiotic	NNS
cord-319163-d1oj15cw	170	3	inhibit	inhibit	VBP
cord-319163-d1oj15cw	170	4	cardiac	cardiac	JJ
cord-319163-d1oj15cw	170	5	myopathies	myopathy	NNS
cord-319163-d1oj15cw	170	6	and	and	CC
cord-319163-d1oj15cw	170	7	autophagy	autophagy	NN
cord-319163-d1oj15cw	170	8	to	to	TO
cord-319163-d1oj15cw	170	9	prevent	prevent	VB
cord-319163-d1oj15cw	170	10	heart	heart	NN
cord-319163-d1oj15cw	170	11	injury	injury	NN
cord-319163-d1oj15cw	170	12	in	in	IN
cord-319163-d1oj15cw	170	13	high	high	JJ
cord-319163-d1oj15cw	170	14	-	-	HYPH
cord-319163-d1oj15cw	170	15	fat	fat	NN
cord-319163-d1oj15cw	170	16	diet	diet	NN
cord-319163-d1oj15cw	170	17	-	-	HYPH
cord-319163-d1oj15cw	170	18	fed	feed	VBN
cord-319163-d1oj15cw	170	19	rats	rat	NNS
cord-319163-d1oj15cw	170	20	Methods	method	NNS
cord-319163-d1oj15cw	170	21	in	in	IN
cord-319163-d1oj15cw	170	22	mammalian	mammalian	JJ
cord-319163-d1oj15cw	170	23	autophagy	autophagy	NN
cord-319163-d1oj15cw	170	24	research	research	NN
cord-319163-d1oj15cw	170	25	Autophagosome	Autophagosome	NNP
cord-319163-d1oj15cw	170	26	formation	formation	NN
cord-319163-d1oj15cw	170	27	:	:	:
cord-319163-d1oj15cw	170	28	core	core	NN
cord-319163-d1oj15cw	170	29	machinery	machinery	NN
cord-319163-d1oj15cw	170	30	and	and	CC
cord-319163-d1oj15cw	170	31	adaptations	adaptation	NNS
cord-319163-d1oj15cw	171	1	Autophagy	Autophagy	NNS
cord-319163-d1oj15cw	171	2	and	and	CC
cord-319163-d1oj15cw	171	3	inflammation	inflammation	NN
cord-319163-d1oj15cw	171	4	Modulation	modulation	NN
cord-319163-d1oj15cw	171	5	of	of	IN
cord-319163-d1oj15cw	171	6	pathogen	pathogen	NN
cord-319163-d1oj15cw	171	7	recognition	recognition	NN
cord-319163-d1oj15cw	171	8	by	by	IN
cord-319163-d1oj15cw	171	9	autophagy	autophagy	NN
cord-319163-d1oj15cw	171	10	Mechanistic	mechanistic	JJ
cord-319163-d1oj15cw	171	11	roles	role	NNS
cord-319163-d1oj15cw	171	12	of	of	IN
cord-319163-d1oj15cw	171	13	autophagy	autophagy	NN
cord-319163-d1oj15cw	171	14	in	in	IN
cord-319163-d1oj15cw	171	15	hematopoietic	hematopoietic	JJ
cord-319163-d1oj15cw	171	16	differentiation	differentiation	NN
cord-319163-d1oj15cw	171	17	Links	link	NNS
cord-319163-d1oj15cw	171	18	of	of	IN
cord-319163-d1oj15cw	171	19	autophagy	autophagy	NN
cord-319163-d1oj15cw	171	20	dysfunction	dysfunction	NN
cord-319163-d1oj15cw	171	21	to	to	IN
cord-319163-d1oj15cw	171	22	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	171	23	bowel	bowel	NN
cord-319163-d1oj15cw	171	24	disease	disease	NN
cord-319163-d1oj15cw	171	25	onset	onset	NN
cord-319163-d1oj15cw	172	1	ATG5	atg5	JJ
cord-319163-d1oj15cw	172	2	,	,	,
cord-319163-d1oj15cw	172	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	172	4	and	and	CC
cord-319163-d1oj15cw	172	5	lung	lung	NN
cord-319163-d1oj15cw	172	6	function	function	NN
cord-319163-d1oj15cw	172	7	in	in	IN
cord-319163-d1oj15cw	172	8	asthma	asthma	NN
cord-319163-d1oj15cw	172	9	Genetic	genetic	JJ
cord-319163-d1oj15cw	172	10	and	and	CC
cord-319163-d1oj15cw	172	11	histologic	histologic	JJ
cord-319163-d1oj15cw	172	12	evidence	evidence	NN
cord-319163-d1oj15cw	172	13	for	for	IN
cord-319163-d1oj15cw	172	14	autophagy	autophagy	NN
cord-319163-d1oj15cw	172	15	in	in	IN
cord-319163-d1oj15cw	172	16	asthma	asthma	NN
cord-319163-d1oj15cw	172	17	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	172	18	Role	role	NN
cord-319163-d1oj15cw	172	19	of	of	IN
cord-319163-d1oj15cw	172	20	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	172	21	airway	airway	NN
cord-319163-d1oj15cw	172	22	inflammation	inflammation	NN
cord-319163-d1oj15cw	172	23	in	in	IN
cord-319163-d1oj15cw	172	24	models	model	NNS
cord-319163-d1oj15cw	172	25	of	of	IN
cord-319163-d1oj15cw	172	26	asthma	asthma	NN
cord-319163-d1oj15cw	172	27	Rothenberg	Rothenberg	NNP
cord-319163-d1oj15cw	172	28	ME	ME	NNP
cord-319163-d1oj15cw	172	29	,	,	,
cord-319163-d1oj15cw	172	30	Hogan	Hogan	NNP
cord-319163-d1oj15cw	172	31	SP	SP	NNP
cord-319163-d1oj15cw	172	32	.	.	.
cord-319163-d1oj15cw	173	1	The	the	DT
cord-319163-d1oj15cw	173	2	eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	173	3	Eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	173	4	airway	airway	NN
cord-319163-d1oj15cw	173	5	inflammation	inflammation	NN
cord-319163-d1oj15cw	173	6	:	:	:
cord-319163-d1oj15cw	173	7	role	role	NN
cord-319163-d1oj15cw	173	8	in	in	IN
cord-319163-d1oj15cw	173	9	asthma	asthma	NN
cord-319163-d1oj15cw	173	10	and	and	CC
cord-319163-d1oj15cw	173	11	chronic	chronic	JJ
cord-319163-d1oj15cw	173	12	obstructive	obstructive	JJ
cord-319163-d1oj15cw	173	13	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	173	14	disease	disease	NN
cord-319163-d1oj15cw	173	15	Eotaxin	Eotaxin	NNP
cord-319163-d1oj15cw	173	16	and	and	CC
cord-319163-d1oj15cw	173	17	the	the	DT
cord-319163-d1oj15cw	173	18	attraction	attraction	NN
cord-319163-d1oj15cw	173	19	of	of	IN
cord-319163-d1oj15cw	173	20	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	173	21	to	to	IN
cord-319163-d1oj15cw	173	22	the	the	DT
cord-319163-d1oj15cw	173	23	asthmatic	asthmatic	JJ
cord-319163-d1oj15cw	173	24	lung	lung	NN
cord-319163-d1oj15cw	173	25	Eosinophils	Eosinophils	NNP
cord-319163-d1oj15cw	173	26	:	:	:
cord-319163-d1oj15cw	173	27	biological	biological	JJ
cord-319163-d1oj15cw	173	28	properties	property	NNS
cord-319163-d1oj15cw	173	29	and	and	CC
cord-319163-d1oj15cw	173	30	role	role	NN
cord-319163-d1oj15cw	173	31	in	in	IN
cord-319163-d1oj15cw	173	32	health	health	NN
cord-319163-d1oj15cw	173	33	and	and	CC
cord-319163-d1oj15cw	173	34	disease	disease	NN
cord-319163-d1oj15cw	173	35	Eosinophil	eosinophil	JJ
cord-319163-d1oj15cw	173	36	cytokines	cytokine	NNS
cord-319163-d1oj15cw	173	37	,	,	,
cord-319163-d1oj15cw	173	38	chemokines	chemokine	NNS
cord-319163-d1oj15cw	173	39	,	,	,
cord-319163-d1oj15cw	173	40	and	and	CC
cord-319163-d1oj15cw	173	41	growth	growth	NN
cord-319163-d1oj15cw	173	42	factors	factor	NNS
cord-319163-d1oj15cw	173	43	:	:	:
cord-319163-d1oj15cw	173	44	emerging	emerge	VBG
cord-319163-d1oj15cw	173	45	roles	role	NNS
cord-319163-d1oj15cw	173	46	in	in	IN
cord-319163-d1oj15cw	173	47	immunity	immunity	NN
cord-319163-d1oj15cw	173	48	Human	human	JJ
cord-319163-d1oj15cw	173	49	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	173	50	regulate	regulate	VBP
cord-319163-d1oj15cw	173	51	human	human	JJ
cord-319163-d1oj15cw	173	52	lung	lung	NN
cord-319163-d1oj15cw	173	53	-	-	:
cord-319163-d1oj15cw	173	54	and	and	CC
cord-319163-d1oj15cw	173	55	skin	skin	NN
cord-319163-d1oj15cw	173	56	-	-	HYPH
cord-319163-d1oj15cw	173	57	derived	derive	VBN
cord-319163-d1oj15cw	173	58	fibroblast	fibroblast	NN
cord-319163-d1oj15cw	173	59	properties	property	NNS
cord-319163-d1oj15cw	173	60	in	in	IN
cord-319163-d1oj15cw	173	61	vitro	vitro	FW
cord-319163-d1oj15cw	173	62	:	:	:
cord-319163-d1oj15cw	173	63	a	a	DT
cord-319163-d1oj15cw	173	64	role	role	NN
cord-319163-d1oj15cw	173	65	for	for	IN
cord-319163-d1oj15cw	173	66	transforming	transform	VBG
cord-319163-d1oj15cw	173	67	growth	growth	NN
cord-319163-d1oj15cw	173	68	factor	factor	NN
cord-319163-d1oj15cw	174	1	beta	beta	NN
cord-319163-d1oj15cw	174	2	(	(	-LRB-
cord-319163-d1oj15cw	174	3	TGF	TGF	NNP
cord-319163-d1oj15cw	174	4	-	-	HYPH
cord-319163-d1oj15cw	174	5	beta	beta	NN
cord-319163-d1oj15cw	174	6	)	)	-RRB-
cord-319163-d1oj15cw	175	1	The	the	DT
cord-319163-d1oj15cw	175	2	regulatory	regulatory	JJ
cord-319163-d1oj15cw	175	3	role	role	NN
cord-319163-d1oj15cw	175	4	of	of	IN
cord-319163-d1oj15cw	175	5	TGF	TGF	NNP
cord-319163-d1oj15cw	175	6	-	-	HYPH
cord-319163-d1oj15cw	175	7	beta	beta	NN
cord-319163-d1oj15cw	175	8	in	in	IN
cord-319163-d1oj15cw	175	9	airway	airway	NN
cord-319163-d1oj15cw	175	10	remodeling	remodeling	NN
cord-319163-d1oj15cw	175	11	in	in	IN
cord-319163-d1oj15cw	175	12	asthma	asthma	NN
cord-319163-d1oj15cw	175	13	Chronic	chronic	JJ
cord-319163-d1oj15cw	175	14	inflammation	inflammation	NN
cord-319163-d1oj15cw	175	15	and	and	CC
cord-319163-d1oj15cw	175	16	asthma	asthma	NN
cord-319163-d1oj15cw	176	1	The	the	DT
cord-319163-d1oj15cw	176	2	regulation	regulation	NN
cord-319163-d1oj15cw	176	3	of	of	IN
cord-319163-d1oj15cw	176	4	allergy	allergy	NN
cord-319163-d1oj15cw	176	5	and	and	CC
cord-319163-d1oj15cw	176	6	asthma	asthma	NN
cord-319163-d1oj15cw	176	7	Airway	Airway	NNP
cord-319163-d1oj15cw	176	8	inflammation	inflammation	NN
cord-319163-d1oj15cw	176	9	in	in	IN
cord-319163-d1oj15cw	176	10	asthma	asthma	NN
cord-319163-d1oj15cw	176	11	:	:	:
cord-319163-d1oj15cw	176	12	key	key	JJ
cord-319163-d1oj15cw	176	13	players	player	NNS
cord-319163-d1oj15cw	176	14	beyond	beyond	IN
cord-319163-d1oj15cw	176	15	the	the	DT
cord-319163-d1oj15cw	176	16	Th2	Th2	NNP
cord-319163-d1oj15cw	176	17	pathway	pathway	NN
cord-319163-d1oj15cw	176	18	TH17	TH17	NNP
cord-319163-d1oj15cw	176	19	cells	cell	NNS
cord-319163-d1oj15cw	176	20	in	in	IN
cord-319163-d1oj15cw	176	21	asthma	asthma	NN
cord-319163-d1oj15cw	176	22	and	and	CC
cord-319163-d1oj15cw	176	23	COPD	COPD	NNP
cord-319163-d1oj15cw	177	1	The	the	DT
cord-319163-d1oj15cw	177	2	relationship	relationship	NN
cord-319163-d1oj15cw	177	3	between	between	IN
cord-319163-d1oj15cw	177	4	airways	airway	NNS
cord-319163-d1oj15cw	177	5	inflammation	inflammation	NN
cord-319163-d1oj15cw	177	6	and	and	CC
cord-319163-d1oj15cw	177	7	asthma	asthma	NN
cord-319163-d1oj15cw	177	8	severity	severity	NN
cord-319163-d1oj15cw	177	9	Relationship	relationship	NN
cord-319163-d1oj15cw	177	10	between	between	IN
cord-319163-d1oj15cw	177	11	airway	airway	NN
cord-319163-d1oj15cw	177	12	inflammation	inflammation	NN
cord-319163-d1oj15cw	177	13	,	,	,
cord-319163-d1oj15cw	177	14	hyperresponsiveness	hyperresponsiveness	NN
cord-319163-d1oj15cw	177	15	,	,	,
cord-319163-d1oj15cw	177	16	and	and	CC
cord-319163-d1oj15cw	177	17	obstruction	obstruction	NN
cord-319163-d1oj15cw	177	18	in	in	IN
cord-319163-d1oj15cw	177	19	asthma	asthma	NN
cord-319163-d1oj15cw	177	20	Allergic	allergic	JJ
cord-319163-d1oj15cw	177	21	sensitization	sensitization	NN
cord-319163-d1oj15cw	177	22	through	through	IN
cord-319163-d1oj15cw	177	23	the	the	DT
cord-319163-d1oj15cw	177	24	airway	airway	NN
cord-319163-d1oj15cw	177	25	primes	prime	NNS
cord-319163-d1oj15cw	177	26	Th17-dependent	Th17-dependent	NNP
cord-319163-d1oj15cw	177	27	neutrophilia	neutrophilia	NNP
cord-319163-d1oj15cw	177	28	and	and	CC
cord-319163-d1oj15cw	177	29	airway	airway	NN
cord-319163-d1oj15cw	177	30	hyperresponsiveness	hyperresponsiveness	NNP
cord-319163-d1oj15cw	177	31	The	the	DT
cord-319163-d1oj15cw	177	32	role	role	NN
cord-319163-d1oj15cw	177	33	of	of	IN
cord-319163-d1oj15cw	177	34	autophagy	autophagy	NN
cord-319163-d1oj15cw	177	35	in	in	IN
cord-319163-d1oj15cw	177	36	allergic	allergic	JJ
cord-319163-d1oj15cw	177	37	inflammation	inflammation	NN
cord-319163-d1oj15cw	177	38	:	:	:
cord-319163-d1oj15cw	178	1	a	a	DT
cord-319163-d1oj15cw	178	2	new	new	JJ
cord-319163-d1oj15cw	178	3	target	target	NN
cord-319163-d1oj15cw	178	4	for	for	IN
cord-319163-d1oj15cw	178	5	severe	severe	JJ
cord-319163-d1oj15cw	178	6	asthma	asthma	NN
cord-319163-d1oj15cw	178	7	Lack	lack	NN
cord-319163-d1oj15cw	178	8	of	of	IN
cord-319163-d1oj15cw	178	9	autophagy	autophagy	NN
cord-319163-d1oj15cw	178	10	induces	induce	VBZ
cord-319163-d1oj15cw	178	11	steroid	steroid	JJ
cord-319163-d1oj15cw	178	12	-	-	HYPH
cord-319163-d1oj15cw	178	13	resistant	resistant	JJ
cord-319163-d1oj15cw	178	14	airway	airway	NN
cord-319163-d1oj15cw	178	15	inflammation	inflammation	NN
cord-319163-d1oj15cw	179	1	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	179	2	is	be	VBZ
cord-319163-d1oj15cw	179	3	a	a	DT
cord-319163-d1oj15cw	179	4	regulator	regulator	NN
cord-319163-d1oj15cw	179	5	of	of	IN
cord-319163-d1oj15cw	179	6	TGF	TGF	NNP
cord-319163-d1oj15cw	179	7	-	-	HYPH
cord-319163-d1oj15cw	179	8	β1-induced	β1-induce	VBN
cord-319163-d1oj15cw	179	9	fibrogenesis	fibrogenesis	NN
cord-319163-d1oj15cw	179	10	in	in	IN
cord-319163-d1oj15cw	179	11	primary	primary	JJ
cord-319163-d1oj15cw	179	12	human	human	JJ
cord-319163-d1oj15cw	179	13	atrial	atrial	JJ
cord-319163-d1oj15cw	179	14	myofibroblasts	myofibroblast	NNS
cord-319163-d1oj15cw	179	15	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	179	16	activation	activation	NN
cord-319163-d1oj15cw	179	17	in	in	IN
cord-319163-d1oj15cw	179	18	asthma	asthma	NNP
cord-319163-d1oj15cw	179	19	airways	airways	NNP
cord-319163-d1oj15cw	179	20	remodeling	remodel	VBG
cord-319163-d1oj15cw	179	21	Suppression	Suppression	NNP
cord-319163-d1oj15cw	179	22	of	of	IN
cord-319163-d1oj15cw	179	23	influenza	influenza	NN
cord-319163-d1oj15cw	179	24	A	a	DT
cord-319163-d1oj15cw	179	25	virus	virus	NN
cord-319163-d1oj15cw	179	26	replication	replication	NN
cord-319163-d1oj15cw	179	27	in	in	IN
cord-319163-d1oj15cw	179	28	human	human	JJ
cord-319163-d1oj15cw	179	29	lung	lung	NN
cord-319163-d1oj15cw	179	30	epithelial	epithelial	NN
cord-319163-d1oj15cw	179	31	cells	cell	NNS
cord-319163-d1oj15cw	179	32	by	by	IN
cord-319163-d1oj15cw	179	33	noncytotoxic	noncytotoxic	NNP
cord-319163-d1oj15cw	179	34	concentrations	concentration	NNS
cord-319163-d1oj15cw	179	35	bafilomycin	bafilomycin	VBZ
cord-319163-d1oj15cw	179	36	A1	A1	NNP
cord-319163-d1oj15cw	179	37	Coronavirus	Coronavirus	NNP
cord-319163-d1oj15cw	179	38	replication	replication	NN
cord-319163-d1oj15cw	179	39	complex	complex	JJ
cord-319163-d1oj15cw	179	40	formation	formation	NN
cord-319163-d1oj15cw	179	41	utilizes	utilize	VBZ
cord-319163-d1oj15cw	179	42	components	component	NNS
cord-319163-d1oj15cw	179	43	of	of	IN
cord-319163-d1oj15cw	179	44	cellular	cellular	JJ
cord-319163-d1oj15cw	179	45	autophagy	autophagy	NN
cord-319163-d1oj15cw	179	46	Coronavirus	Coronavirus	NNP
cord-319163-d1oj15cw	179	47	nsp6	nsp6	NN
cord-319163-d1oj15cw	179	48	proteins	protein	NNS
cord-319163-d1oj15cw	179	49	generate	generate	VBP
cord-319163-d1oj15cw	179	50	autophagosomes	autophagosome	NNS
cord-319163-d1oj15cw	179	51	from	from	IN
cord-319163-d1oj15cw	179	52	the	the	DT
cord-319163-d1oj15cw	179	53	endoplasmic	endoplasmic	NN
cord-319163-d1oj15cw	179	54	reticulum	reticulum	NN
cord-319163-d1oj15cw	179	55	via	via	IN
cord-319163-d1oj15cw	179	56	an	an	DT
cord-319163-d1oj15cw	179	57	omegasome	omegasome	NN
cord-319163-d1oj15cw	179	58	intermediate	intermediate	JJ
cord-319163-d1oj15cw	179	59	Inflammatory	Inflammatory	NNP
cord-319163-d1oj15cw	179	60	mechanisms	mechanism	NNS
cord-319163-d1oj15cw	179	61	in	in	IN
cord-319163-d1oj15cw	179	62	patients	patient	NNS
cord-319163-d1oj15cw	179	63	with	with	IN
cord-319163-d1oj15cw	179	64	chronic	chronic	JJ
cord-319163-d1oj15cw	179	65	obstructive	obstructive	JJ
cord-319163-d1oj15cw	179	66	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	179	67	disease	disease	NN
cord-319163-d1oj15cw	179	68	Chronic	Chronic	NNP
cord-319163-d1oj15cw	179	69	obstructive	obstructive	JJ
cord-319163-d1oj15cw	179	70	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	179	71	disease	disease	NN
cord-319163-d1oj15cw	179	72	Global	global	JJ
cord-319163-d1oj15cw	179	73	strategy	strategy	NN
cord-319163-d1oj15cw	179	74	for	for	IN
cord-319163-d1oj15cw	180	1	the	the	DT
cord-319163-d1oj15cw	180	2	diagnosis	diagnosis	NN
cord-319163-d1oj15cw	180	3	,	,	,
cord-319163-d1oj15cw	180	4	management	management	NN
cord-319163-d1oj15cw	180	5	,	,	,
cord-319163-d1oj15cw	180	6	and	and	CC
cord-319163-d1oj15cw	180	7	prevention	prevention	NN
cord-319163-d1oj15cw	180	8	of	of	IN
cord-319163-d1oj15cw	180	9	chronic	chronic	JJ
cord-319163-d1oj15cw	180	10	obstructive	obstructive	JJ
cord-319163-d1oj15cw	180	11	lung	lung	NN
cord-319163-d1oj15cw	180	12	disease	disease	NN
cord-319163-d1oj15cw	180	13	2017	2017	CD
cord-319163-d1oj15cw	180	14	report	report	NN
cord-319163-d1oj15cw	180	15	:	:	:
cord-319163-d1oj15cw	180	16	GOLD	gold	NN
cord-319163-d1oj15cw	180	17	executive	executive	NN
cord-319163-d1oj15cw	180	18	summary	summary	NN
cord-319163-d1oj15cw	181	1	Eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	181	2	airway	airway	NN
cord-319163-d1oj15cw	181	3	inflammation	inflammation	NN
cord-319163-d1oj15cw	181	4	in	in	IN
cord-319163-d1oj15cw	181	5	COPD	COPD	NNP
cord-319163-d1oj15cw	181	6	Role	role	NN
cord-319163-d1oj15cw	181	7	of	of	IN
cord-319163-d1oj15cw	181	8	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	181	9	in	in	IN
cord-319163-d1oj15cw	181	10	airway	airway	NN
cord-319163-d1oj15cw	181	11	inflammation	inflammation	NN
cord-319163-d1oj15cw	181	12	of	of	IN
cord-319163-d1oj15cw	181	13	chronic	chronic	JJ
cord-319163-d1oj15cw	181	14	obstructive	obstructive	JJ
cord-319163-d1oj15cw	181	15	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	181	16	disease	disease	NN
cord-319163-d1oj15cw	182	1	Egr-1	Egr-1	NNP
cord-319163-d1oj15cw	182	2	regulates	regulate	VBZ
cord-319163-d1oj15cw	182	3	autophagy	autophagy	NN
cord-319163-d1oj15cw	182	4	in	in	IN
cord-319163-d1oj15cw	182	5	cigarette	cigarette	NN
cord-319163-d1oj15cw	182	6	smoke	smoke	NN
cord-319163-d1oj15cw	182	7	-	-	HYPH
cord-319163-d1oj15cw	182	8	induced	induce	VBN
cord-319163-d1oj15cw	182	9	chronic	chronic	JJ
cord-319163-d1oj15cw	182	10	obstructive	obstructive	JJ
cord-319163-d1oj15cw	182	11	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	182	12	disease	disease	NN
cord-319163-d1oj15cw	182	13	Autophagic	Autophagic	NNP
cord-319163-d1oj15cw	182	14	proteins	protein	NNS
cord-319163-d1oj15cw	182	15	regulate	regulate	VBP
cord-319163-d1oj15cw	182	16	cigarette	cigarette	NN
cord-319163-d1oj15cw	182	17	smoke	smoke	NN
cord-319163-d1oj15cw	182	18	-	-	HYPH
cord-319163-d1oj15cw	182	19	induced	induce	VBN
cord-319163-d1oj15cw	182	20	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	182	21	:	:	:
cord-319163-d1oj15cw	183	1	protective	protective	JJ
cord-319163-d1oj15cw	183	2	role	role	NN
cord-319163-d1oj15cw	183	3	of	of	IN
cord-319163-d1oj15cw	183	4	heme	heme	NN
cord-319163-d1oj15cw	183	5	oxygenase-1	oxygenase-1	NNP
cord-319163-d1oj15cw	183	6	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	183	7	protein	protein	NN
cord-319163-d1oj15cw	183	8	microtubule	microtubule	NN
cord-319163-d1oj15cw	183	9	-	-	HYPH
cord-319163-d1oj15cw	183	10	associated	associate	VBN
cord-319163-d1oj15cw	183	11	protein	protein	NN
cord-319163-d1oj15cw	183	12	1	1	CD
cord-319163-d1oj15cw	183	13	light	light	NN
cord-319163-d1oj15cw	183	14	chain-3B	chain-3b	NN
cord-319163-d1oj15cw	183	15	(	(	-LRB-
cord-319163-d1oj15cw	183	16	LC3B	lc3b	NN
cord-319163-d1oj15cw	183	17	)	)	-RRB-
cord-319163-d1oj15cw	183	18	activates	activate	VBZ
cord-319163-d1oj15cw	183	19	extrinsic	extrinsic	JJ
cord-319163-d1oj15cw	183	20	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	183	21	during	during	IN
cord-319163-d1oj15cw	183	22	cigarette	cigarette	NN
cord-319163-d1oj15cw	183	23	smoke	smoke	NN
cord-319163-d1oj15cw	183	24	-	-	HYPH
cord-319163-d1oj15cw	183	25	induced	induce	VBN
cord-319163-d1oj15cw	183	26	emphysema	emphysema	NN
cord-319163-d1oj15cw	183	27	Oxidative	oxidative	JJ
cord-319163-d1oj15cw	183	28	stress	stress	NN
cord-319163-d1oj15cw	183	29	and	and	CC
cord-319163-d1oj15cw	183	30	autophagy	autophagy	NN
cord-319163-d1oj15cw	183	31	Oxidative	oxidative	JJ
cord-319163-d1oj15cw	183	32	stress	stress	NN
cord-319163-d1oj15cw	183	33	in	in	IN
cord-319163-d1oj15cw	183	34	COPD	COPD	NNP
cord-319163-d1oj15cw	183	35	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	183	36	in	in	IN
cord-319163-d1oj15cw	183	37	cigarette	cigarette	NN
cord-319163-d1oj15cw	183	38	smoke	smoke	NN
cord-319163-d1oj15cw	183	39	-	-	HYPH
cord-319163-d1oj15cw	183	40	induced	induce	VBN
cord-319163-d1oj15cw	183	41	chronic	chronic	JJ
cord-319163-d1oj15cw	183	42	obstructive	obstructive	JJ
cord-319163-d1oj15cw	183	43	pulmonary	pulmonary	JJ
cord-319163-d1oj15cw	183	44	disease	disease	NN
cord-319163-d1oj15cw	184	1	Reactive	reactive	JJ
cord-319163-d1oj15cw	184	2	oxygen	oxygen	NN
cord-319163-d1oj15cw	184	3	species	specie	NNS
cord-319163-d1oj15cw	184	4	are	be	VBP
cord-319163-d1oj15cw	184	5	essential	essential	JJ
cord-319163-d1oj15cw	184	6	for	for	IN
cord-319163-d1oj15cw	184	7	autophagy	autophagy	NN
cord-319163-d1oj15cw	184	8	and	and	CC
cord-319163-d1oj15cw	184	9	specifically	specifically	RB
cord-319163-d1oj15cw	184	10	regulate	regulate	VB
cord-319163-d1oj15cw	184	11	the	the	DT
cord-319163-d1oj15cw	184	12	activity	activity	NN
cord-319163-d1oj15cw	184	13	of	of	IN
cord-319163-d1oj15cw	184	14	Atg4	Atg4	NNP
cord-319163-d1oj15cw	184	15	Oxidative	Oxidative	NNP
cord-319163-d1oj15cw	184	16	stress	stress	NN
cord-319163-d1oj15cw	184	17	induces	induce	VBZ
cord-319163-d1oj15cw	184	18	autophagic	autophagic	JJ
cord-319163-d1oj15cw	184	19	cell	cell	NN
cord-319163-d1oj15cw	184	20	death	death	NN
cord-319163-d1oj15cw	184	21	independent	independent	JJ
cord-319163-d1oj15cw	184	22	of	of	IN
cord-319163-d1oj15cw	184	23	apoptosis	apoptosis	NN
cord-319163-d1oj15cw	184	24	in	in	IN
cord-319163-d1oj15cw	184	25	transformed	transform	VBN
cord-319163-d1oj15cw	184	26	and	and	CC
cord-319163-d1oj15cw	184	27	cancer	cancer	NN
cord-319163-d1oj15cw	184	28	cells	cell	NNS
cord-319163-d1oj15cw	185	1	Airway	airway	JJ
cord-319163-d1oj15cw	185	2	mucosal	mucosal	JJ
cord-319163-d1oj15cw	185	3	inflammation	inflammation	NN
cord-319163-d1oj15cw	185	4	in	in	IN
cord-319163-d1oj15cw	185	5	COPD	COPD	NNP
cord-319163-d1oj15cw	185	6	is	be	VBZ
cord-319163-d1oj15cw	185	7	similar	similar	JJ
cord-319163-d1oj15cw	185	8	in	in	IN
cord-319163-d1oj15cw	185	9	smokers	smoker	NNS
cord-319163-d1oj15cw	185	10	and	and	CC
cord-319163-d1oj15cw	185	11	ex	ex	NNS
cord-319163-d1oj15cw	185	12	-	-	NNS
cord-319163-d1oj15cw	185	13	smokers	smoker	NNS
cord-319163-d1oj15cw	185	14	:	:	:
cord-319163-d1oj15cw	185	15	a	a	DT
cord-319163-d1oj15cw	185	16	pooled	pool	VBN
cord-319163-d1oj15cw	185	17	analysis	analysis	NN
cord-319163-d1oj15cw	185	18	European	european	JJ
cord-319163-d1oj15cw	185	19	position	position	NN
cord-319163-d1oj15cw	185	20	paper	paper	NN
cord-319163-d1oj15cw	185	21	on	on	IN
cord-319163-d1oj15cw	185	22	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	185	23	and	and	CC
cord-319163-d1oj15cw	185	24	nasal	nasal	NN
cord-319163-d1oj15cw	185	25	polyps	polyp	NNS
cord-319163-d1oj15cw	185	26	2012	2012	CD
cord-319163-d1oj15cw	185	27	.	.	.
cord-319163-d1oj15cw	186	1	A	a	DT
cord-319163-d1oj15cw	186	2	summary	summary	NN
cord-319163-d1oj15cw	186	3	for	for	IN
cord-319163-d1oj15cw	186	4	otorhinolaryngologists	otorhinolaryngologist	NNS
cord-319163-d1oj15cw	186	5	Chronic	Chronic	NNP
cord-319163-d1oj15cw	186	6	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	186	7	pathogenesis	pathogenesis	NN
cord-319163-d1oj15cw	186	8	Pathogenesis	Pathogenesis	NNP
cord-319163-d1oj15cw	186	9	of	of	IN
cord-319163-d1oj15cw	186	10	chronic	chronic	JJ
cord-319163-d1oj15cw	186	11	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	186	12	:	:	:
cord-319163-d1oj15cw	186	13	inflammation	inflammation	NN
cord-319163-d1oj15cw	186	14	Immunopathology	immunopathology	NN
cord-319163-d1oj15cw	186	15	of	of	IN
cord-319163-d1oj15cw	186	16	chronic	chronic	JJ
cord-319163-d1oj15cw	186	17	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	186	18	Clinical	clinical	JJ
cord-319163-d1oj15cw	186	19	and	and	CC
cord-319163-d1oj15cw	186	20	biological	biological	JJ
cord-319163-d1oj15cw	186	21	markers	marker	NNS
cord-319163-d1oj15cw	186	22	of	of	IN
cord-319163-d1oj15cw	186	23	difficult	difficult	JJ
cord-319163-d1oj15cw	186	24	-	-	HYPH
cord-319163-d1oj15cw	186	25	to	to	TO
cord-319163-d1oj15cw	186	26	-	-	HYPH
cord-319163-d1oj15cw	186	27	treat	treat	VB
cord-319163-d1oj15cw	186	28	severe	severe	JJ
cord-319163-d1oj15cw	186	29	chronic	chronic	NN
cord-319163-d1oj15cw	186	30	rhinosinusitis	rhinosinusitis	NNP
cord-319163-d1oj15cw	186	31	Pathogenesis	Pathogenesis	NNP
cord-319163-d1oj15cw	186	32	of	of	IN
cord-319163-d1oj15cw	186	33	eosinophilic	eosinophilic	JJ
cord-319163-d1oj15cw	186	34	chronic	chronic	JJ
cord-319163-d1oj15cw	186	35	rhinosinusitis	rhinosinusitis	NNP
cord-319163-d1oj15cw	186	36	Classification	Classification	NNP
cord-319163-d1oj15cw	186	37	of	of	IN
cord-319163-d1oj15cw	186	38	chronic	chronic	JJ
cord-319163-d1oj15cw	186	39	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	186	40	according	accord	VBG
cord-319163-d1oj15cw	186	41	to	to	IN
cord-319163-d1oj15cw	186	42	a	a	DT
cord-319163-d1oj15cw	186	43	nasal	nasal	NN
cord-319163-d1oj15cw	186	44	polyp	polyp	NN
cord-319163-d1oj15cw	186	45	and	and	CC
cord-319163-d1oj15cw	186	46	tissue	tissue	NN
cord-319163-d1oj15cw	186	47	eosinophilia	eosinophilia	NN
cord-319163-d1oj15cw	186	48	:	:	:
cord-319163-d1oj15cw	186	49	limitation	limitation	NN
cord-319163-d1oj15cw	186	50	of	of	IN
cord-319163-d1oj15cw	186	51	current	current	JJ
cord-319163-d1oj15cw	186	52	classification	classification	NN
cord-319163-d1oj15cw	186	53	system	system	NN
cord-319163-d1oj15cw	186	54	for	for	IN
cord-319163-d1oj15cw	186	55	Asian	asian	JJ
cord-319163-d1oj15cw	186	56	population	population	NN
cord-319163-d1oj15cw	186	57	Differentiation	differentiation	NN
cord-319163-d1oj15cw	186	58	of	of	IN
cord-319163-d1oj15cw	186	59	chronic	chronic	JJ
cord-319163-d1oj15cw	186	60	sinus	sinus	NN
cord-319163-d1oj15cw	186	61	diseases	disease	NNS
cord-319163-d1oj15cw	186	62	by	by	IN
cord-319163-d1oj15cw	186	63	measurement	measurement	NN
cord-319163-d1oj15cw	186	64	of	of	IN
cord-319163-d1oj15cw	186	65	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	186	66	mediators	mediator	NNS
cord-319163-d1oj15cw	186	67	Different	different	JJ
cord-319163-d1oj15cw	186	68	types	type	NNS
cord-319163-d1oj15cw	186	69	of	of	IN
cord-319163-d1oj15cw	186	70	T	t	NN
cord-319163-d1oj15cw	186	71	-	-	HYPH
cord-319163-d1oj15cw	186	72	effector	effector	NN
cord-319163-d1oj15cw	186	73	cells	cell	NNS
cord-319163-d1oj15cw	186	74	orchestrate	orchestrate	VBP
cord-319163-d1oj15cw	186	75	mucosal	mucosal	JJ
cord-319163-d1oj15cw	186	76	inflammation	inflammation	NN
cord-319163-d1oj15cw	186	77	in	in	IN
cord-319163-d1oj15cw	186	78	chronic	chronic	JJ
cord-319163-d1oj15cw	186	79	sinus	sinus	NN
cord-319163-d1oj15cw	186	80	disease	disease	NN
cord-319163-d1oj15cw	187	1	Distinct	distinct	JJ
cord-319163-d1oj15cw	187	2	immunopathologic	immunopathologic	JJ
cord-319163-d1oj15cw	187	3	characteristics	characteristic	NNS
cord-319163-d1oj15cw	187	4	of	of	IN
cord-319163-d1oj15cw	187	5	various	various	JJ
cord-319163-d1oj15cw	187	6	types	type	NNS
cord-319163-d1oj15cw	187	7	of	of	IN
cord-319163-d1oj15cw	187	8	chronic	chronic	JJ
cord-319163-d1oj15cw	187	9	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	187	10	in	in	IN
cord-319163-d1oj15cw	187	11	adult	adult	NN
cord-319163-d1oj15cw	187	12	Chinese	Chinese	NNP
cord-319163-d1oj15cw	187	13	Histological	Histological	NNP
cord-319163-d1oj15cw	187	14	and	and	CC
cord-319163-d1oj15cw	187	15	immunological	immunological	JJ
cord-319163-d1oj15cw	187	16	features	feature	NNS
cord-319163-d1oj15cw	187	17	of	of	IN
cord-319163-d1oj15cw	187	18	noneosinophilic	noneosinophilic	JJ
cord-319163-d1oj15cw	187	19	nasal	nasal	NN
cord-319163-d1oj15cw	187	20	polyps	polyp	NNS
cord-319163-d1oj15cw	187	21	Subclassification	Subclassification	NNP
cord-319163-d1oj15cw	187	22	of	of	IN
cord-319163-d1oj15cw	187	23	chronic	chronic	JJ
cord-319163-d1oj15cw	187	24	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	187	25	with	with	IN
cord-319163-d1oj15cw	187	26	nasal	nasal	NN
cord-319163-d1oj15cw	187	27	polyp	polyp	NN
cord-319163-d1oj15cw	187	28	based	base	VBN
cord-319163-d1oj15cw	187	29	on	on	IN
cord-319163-d1oj15cw	187	30	eosinophil	eosinophil	NN
cord-319163-d1oj15cw	187	31	and	and	CC
cord-319163-d1oj15cw	187	32	neutrophil	neutrophil	NN
cord-319163-d1oj15cw	188	1	Increased	increase	VBN
cord-319163-d1oj15cw	189	1	noneosinophilic	noneosinophilic	JJ
cord-319163-d1oj15cw	189	2	nasal	nasal	NN
cord-319163-d1oj15cw	189	3	polyps	polyp	NNS
cord-319163-d1oj15cw	189	4	in	in	IN
cord-319163-d1oj15cw	189	5	chronic	chronic	JJ
cord-319163-d1oj15cw	189	6	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	189	7	in	in	IN
cord-319163-d1oj15cw	189	8	US	US	NNP
cord-319163-d1oj15cw	189	9	secondgeneration	secondgeneration	NN
cord-319163-d1oj15cw	189	10	Asians	Asians	NNPS
cord-319163-d1oj15cw	189	11	suggest	suggest	VBP
cord-319163-d1oj15cw	189	12	genetic	genetic	JJ
cord-319163-d1oj15cw	189	13	regulation	regulation	NN
cord-319163-d1oj15cw	189	14	of	of	IN
cord-319163-d1oj15cw	189	15	eosinophilia	eosinophilia	NNP
cord-319163-d1oj15cw	189	16	Measurement	Measurement	NNP
cord-319163-d1oj15cw	189	17	of	of	IN
cord-319163-d1oj15cw	189	18	inflammatory	inflammatory	JJ
cord-319163-d1oj15cw	189	19	mediators	mediator	NNS
cord-319163-d1oj15cw	189	20	of	of	IN
cord-319163-d1oj15cw	189	21	mast	mast	NN
cord-319163-d1oj15cw	189	22	cells	cell	NNS
cord-319163-d1oj15cw	189	23	and	and	CC
cord-319163-d1oj15cw	189	24	eosinophils	eosinophil	NNS
cord-319163-d1oj15cw	189	25	in	in	IN
cord-319163-d1oj15cw	189	26	native	native	JJ
cord-319163-d1oj15cw	189	27	nasal	nasal	NN
cord-319163-d1oj15cw	189	28	lavage	lavage	NN
cord-319163-d1oj15cw	189	29	fluid	fluid	NN
cord-319163-d1oj15cw	189	30	in	in	IN
cord-319163-d1oj15cw	189	31	nasal	nasal	NN
cord-319163-d1oj15cw	189	32	polyposis	polyposis	NN
cord-319163-d1oj15cw	189	33	Role	role	NN
cord-319163-d1oj15cw	189	34	of	of	IN
cord-319163-d1oj15cw	189	35	mast	mast	NN
cord-319163-d1oj15cw	189	36	cells	cell	NNS
cord-319163-d1oj15cw	189	37	and	and	CC
cord-319163-d1oj15cw	189	38	basophils	basophil	NNS
cord-319163-d1oj15cw	189	39	in	in	IN
cord-319163-d1oj15cw	189	40	chronic	chronic	JJ
cord-319163-d1oj15cw	189	41	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	189	42	Correlation	Correlation	NNP
cord-319163-d1oj15cw	189	43	between	between	IN
cord-319163-d1oj15cw	189	44	the	the	DT
cord-319163-d1oj15cw	189	45	prostaglandin	prostaglandin	NN
cord-319163-d1oj15cw	189	46	D(2)/E(2	D(2)/E(2	NNP
cord-319163-d1oj15cw	189	47	)	)	-RRB-
cord-319163-d1oj15cw	189	48	ratio	ratio	NN
cord-319163-d1oj15cw	189	49	in	in	IN
cord-319163-d1oj15cw	189	50	nasal	nasal	NN
cord-319163-d1oj15cw	189	51	polyps	polyp	NNS
cord-319163-d1oj15cw	189	52	and	and	CC
cord-319163-d1oj15cw	189	53	the	the	DT
cord-319163-d1oj15cw	189	54	recalcitrant	recalcitrant	JJ
cord-319163-d1oj15cw	189	55	pathophysiology	pathophysiology	NN
cord-319163-d1oj15cw	189	56	of	of	IN
cord-319163-d1oj15cw	189	57	chronic	chronic	JJ
cord-319163-d1oj15cw	189	58	rhinosinusitis	rhinosinusitis	NN
cord-319163-d1oj15cw	189	59	associated	associate	VBN
cord-319163-d1oj15cw	189	60	with	with	IN
cord-319163-d1oj15cw	189	61	bronchial	bronchial	JJ
cord-319163-d1oj15cw	189	62	asthma	asthma	NN
cord-319163-d1oj15cw	189	63	Role	role	NN
cord-319163-d1oj15cw	189	64	of	of	IN
cord-319163-d1oj15cw	189	65	prostaglandin	prostaglandin	NN
cord-319163-d1oj15cw	189	66	D2	d2	NN
cord-319163-d1oj15cw	189	67	and	and	CC
cord-319163-d1oj15cw	189	68	E2	E2	NNP
cord-319163-d1oj15cw	189	69	terminal	terminal	NN
cord-319163-d1oj15cw	189	70	synthases	synthase	NNS
cord-319163-d1oj15cw	189	71	in	in	IN
cord-319163-d1oj15cw	189	72	chronic	chronic	JJ
cord-319163-d1oj15cw	189	73	rhinosinusitis	rhinosinusitis	NNP
cord-319163-d1oj15cw	189	74	Macrophage	Macrophage	NNP
cord-319163-d1oj15cw	189	75	autophagy	autophagy	NN
cord-319163-d1oj15cw	189	76	limits	limit	VBZ
cord-319163-d1oj15cw	189	77	acute	acute	JJ
cord-319163-d1oj15cw	189	78	toxic	toxic	JJ
cord-319163-d1oj15cw	189	79	liver	liver	NN
cord-319163-d1oj15cw	189	80	injury	injury	NN
cord-319163-d1oj15cw	189	81	in	in	IN
cord-319163-d1oj15cw	189	82	mice	mouse	NNS
cord-319163-d1oj15cw	189	83	through	through	IN
cord-319163-d1oj15cw	189	84	down	down	JJ
cord-319163-d1oj15cw	189	85	regulation	regulation	NN
cord-319163-d1oj15cw	189	86	of	of	IN
cord-319163-d1oj15cw	189	87	interleukin-1β	interleukin-1β	NNP
cord-319163-d1oj15cw	189	88	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	189	89	deficiency	deficiency	NN
cord-319163-d1oj15cw	189	90	in	in	IN
cord-319163-d1oj15cw	189	91	myeloid	myeloid	JJ
cord-319163-d1oj15cw	189	92	cells	cell	NNS
cord-319163-d1oj15cw	189	93	increases	increase	VBZ
cord-319163-d1oj15cw	189	94	susceptibility	susceptibility	NN
cord-319163-d1oj15cw	189	95	to	to	IN
cord-319163-d1oj15cw	189	96	obesity	obesity	NN
cord-319163-d1oj15cw	189	97	-	-	HYPH
cord-319163-d1oj15cw	189	98	induced	induce	VBN
cord-319163-d1oj15cw	189	99	diabetes	diabetes	NN
cord-319163-d1oj15cw	189	100	and	and	CC
cord-319163-d1oj15cw	189	101	experimental	experimental	JJ
cord-319163-d1oj15cw	189	102	colitis	colitis	NN
cord-319163-d1oj15cw	189	103	Autophagy	Autophagy	NNP
cord-319163-d1oj15cw	189	104	protects	protect	VBZ
cord-319163-d1oj15cw	189	105	against	against	IN
cord-319163-d1oj15cw	189	106	active	active	JJ
cord-319163-d1oj15cw	189	107	tuberculosis	tuberculosis	NN
cord-319163-d1oj15cw	189	108	by	by	IN
cord-319163-d1oj15cw	189	109	suppressing	suppress	VBG
cord-319163-d1oj15cw	189	110	bacterial	bacterial	JJ
cord-319163-d1oj15cw	189	111	burden	burden	NN
cord-319163-d1oj15cw	189	112	and	and	CC
cord-319163-d1oj15cw	189	113	inflammation	inflammation	NN