id	sid	tid	token	lemma	pos
cord-344835-iivry1ou	1	1	key	key	NN
cord-344835-iivry1ou	1	2	:	:	:
cord-344835-iivry1ou	2	1	cord-344835-iivry1ou	cord-344835-iivry1ou	.
cord-344835-iivry1ou	3	1	authors	author	NNS
cord-344835-iivry1ou	3	2	:	:	:
cord-344835-iivry1ou	3	3	Tsoumakidou	Tsoumakidou	NNP
cord-344835-iivry1ou	3	4	,	,	,
cord-344835-iivry1ou	3	5	Maria	Maria	NNP
cord-344835-iivry1ou	3	6	;	;	:
cord-344835-iivry1ou	3	7	Siafakas	Siafakas	NNP
cord-344835-iivry1ou	3	8	,	,	,
cord-344835-iivry1ou	3	9	Nikolaos	Nikolaos	NNP
cord-344835-iivry1ou	3	10	M	M	NNP
cord-344835-iivry1ou	3	11	title	title	NN
cord-344835-iivry1ou	3	12	:	:	:
cord-344835-iivry1ou	4	1	Novel	novel	JJ
cord-344835-iivry1ou	4	2	insights	insight	NNS
cord-344835-iivry1ou	4	3	into	into	IN
cord-344835-iivry1ou	4	4	the	the	DT
cord-344835-iivry1ou	4	5	aetiology	aetiology	NN
cord-344835-iivry1ou	4	6	and	and	CC
cord-344835-iivry1ou	4	7	pathophysiology	pathophysiology	NN
cord-344835-iivry1ou	4	8	of	of	IN
cord-344835-iivry1ou	4	9	increased	increase	VBN
cord-344835-iivry1ou	4	10	airway	airway	NN
cord-344835-iivry1ou	4	11	inflammation	inflammation	NN
cord-344835-iivry1ou	4	12	during	during	IN
cord-344835-iivry1ou	4	13	COPD	COPD	NNP
cord-344835-iivry1ou	4	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	4	15	date	date	NN
cord-344835-iivry1ou	4	16	:	:	:
cord-344835-iivry1ou	4	17	2006	2006	CD
cord-344835-iivry1ou	4	18	-	-	HYPH
cord-344835-iivry1ou	4	19	05	05	CD
cord-344835-iivry1ou	4	20	-	-	HYPH
cord-344835-iivry1ou	4	21	22	22	CD
cord-344835-iivry1ou	4	22	journal	journal	NN
cord-344835-iivry1ou	4	23	:	:	:
cord-344835-iivry1ou	5	1	Respir	Respir	NNP
cord-344835-iivry1ou	5	2	Res	Res	NNP
cord-344835-iivry1ou	5	3	DOI	doi	NN
cord-344835-iivry1ou	5	4	:	:	:
cord-344835-iivry1ou	5	5	10.1186/1465	10.1186/1465	CD
cord-344835-iivry1ou	5	6	-	-	HYPH
cord-344835-iivry1ou	5	7	9921	9921	CD
cord-344835-iivry1ou	5	8	-	-	HYPH
cord-344835-iivry1ou	5	9	7	7	CD
cord-344835-iivry1ou	5	10	-	-	SYM
cord-344835-iivry1ou	5	11	80	80	CD
cord-344835-iivry1ou	6	1	sha	sha	NNP
cord-344835-iivry1ou	6	2	:	:	:
cord-344835-iivry1ou	6	3	8f11250121c352f2caa5203e9a487d581cf26039	8f11250121c352f2caa5203e9a487d581cf26039	CD
cord-344835-iivry1ou	6	4	doc_id	doc_id	CD
cord-344835-iivry1ou	6	5	:	:	:
cord-344835-iivry1ou	6	6	344835	344835	CD
cord-344835-iivry1ou	6	7	cord_uid	cord_uid	NNS
cord-344835-iivry1ou	6	8	:	:	:
cord-344835-iivry1ou	7	1	iivry1ou	iivry1ou	NNP
cord-344835-iivry1ou	7	2	Airway	Airway	NNP
cord-344835-iivry1ou	7	3	inflammation	inflammation	NN
cord-344835-iivry1ou	7	4	increases	increase	NNS
cord-344835-iivry1ou	7	5	during	during	IN
cord-344835-iivry1ou	7	6	acute	acute	JJ
cord-344835-iivry1ou	7	7	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	7	8	of	of	IN
cord-344835-iivry1ou	7	9	COPD	COPD	NNP
cord-344835-iivry1ou	7	10	.	.	.
cord-344835-iivry1ou	8	1	Extrinsic	extrinsic	JJ
cord-344835-iivry1ou	8	2	factors	factor	NNS
cord-344835-iivry1ou	8	3	,	,	,
cord-344835-iivry1ou	8	4	such	such	JJ
cord-344835-iivry1ou	8	5	as	as	IN
cord-344835-iivry1ou	8	6	airway	airway	NN
cord-344835-iivry1ou	8	7	infections	infection	NNS
cord-344835-iivry1ou	8	8	,	,	,
cord-344835-iivry1ou	8	9	increased	increase	VBN
cord-344835-iivry1ou	8	10	air	air	NN
cord-344835-iivry1ou	8	11	pollution	pollution	NN
cord-344835-iivry1ou	8	12	,	,	,
cord-344835-iivry1ou	8	13	and	and	CC
cord-344835-iivry1ou	8	14	intrinsic	intrinsic	JJ
cord-344835-iivry1ou	8	15	factors	factor	NNS
cord-344835-iivry1ou	8	16	,	,	,
cord-344835-iivry1ou	8	17	such	such	JJ
cord-344835-iivry1ou	8	18	as	as	IN
cord-344835-iivry1ou	8	19	increased	increase	VBN
cord-344835-iivry1ou	8	20	oxidative	oxidative	JJ
cord-344835-iivry1ou	8	21	stress	stress	NN
cord-344835-iivry1ou	8	22	and	and	CC
cord-344835-iivry1ou	8	23	altered	alter	VBN
cord-344835-iivry1ou	8	24	immunity	immunity	NN
cord-344835-iivry1ou	8	25	may	may	MD
cord-344835-iivry1ou	8	26	contribute	contribute	VB
cord-344835-iivry1ou	8	27	to	to	IN
cord-344835-iivry1ou	8	28	this	this	DT
cord-344835-iivry1ou	8	29	increase	increase	NN
cord-344835-iivry1ou	8	30	.	.	.
cord-344835-iivry1ou	9	1	The	the	DT
cord-344835-iivry1ou	9	2	evidence	evidence	NN
cord-344835-iivry1ou	9	3	for	for	IN
cord-344835-iivry1ou	9	4	this	this	DT
cord-344835-iivry1ou	9	5	and	and	CC
cord-344835-iivry1ou	9	6	the	the	DT
cord-344835-iivry1ou	9	7	potential	potential	JJ
cord-344835-iivry1ou	9	8	mechanisms	mechanism	NNS
cord-344835-iivry1ou	9	9	by	by	IN
cord-344835-iivry1ou	9	10	which	which	WDT
cord-344835-iivry1ou	9	11	various	various	JJ
cord-344835-iivry1ou	9	12	aetiological	aetiological	JJ
cord-344835-iivry1ou	9	13	agents	agent	NNS
cord-344835-iivry1ou	9	14	increase	increase	VBP
cord-344835-iivry1ou	9	15	inflammation	inflammation	NN
cord-344835-iivry1ou	9	16	during	during	IN
cord-344835-iivry1ou	9	17	COPD	COPD	NNP
cord-344835-iivry1ou	9	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	9	19	is	be	VBZ
cord-344835-iivry1ou	9	20	reviewed	review	VBN
cord-344835-iivry1ou	9	21	.	.	.
cord-344835-iivry1ou	10	1	The	the	DT
cord-344835-iivry1ou	10	2	pathophysiologic	pathophysiologic	JJ
cord-344835-iivry1ou	10	3	consequences	consequence	NNS
cord-344835-iivry1ou	10	4	of	of	IN
cord-344835-iivry1ou	10	5	increased	increase	VBN
cord-344835-iivry1ou	10	6	airway	airway	NN
cord-344835-iivry1ou	10	7	inflammation	inflammation	NN
cord-344835-iivry1ou	10	8	during	during	IN
cord-344835-iivry1ou	10	9	COPD	COPD	NNP
cord-344835-iivry1ou	10	10	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	10	11	are	be	VBP
cord-344835-iivry1ou	10	12	also	also	RB
cord-344835-iivry1ou	10	13	discussed	discuss	VBN
cord-344835-iivry1ou	10	14	.	.	.
cord-344835-iivry1ou	11	1	This	this	DT
cord-344835-iivry1ou	11	2	review	review	NN
cord-344835-iivry1ou	11	3	aims	aim	VBZ
cord-344835-iivry1ou	11	4	to	to	TO
cord-344835-iivry1ou	11	5	establish	establish	VB
cord-344835-iivry1ou	11	6	a	a	DT
cord-344835-iivry1ou	11	7	cause	cause	NN
cord-344835-iivry1ou	11	8	and	and	CC
cord-344835-iivry1ou	11	9	effect	effect	NN
cord-344835-iivry1ou	11	10	relationship	relationship	NN
cord-344835-iivry1ou	11	11	between	between	IN
cord-344835-iivry1ou	11	12	etiological	etiological	JJ
cord-344835-iivry1ou	11	13	factors	factor	NNS
cord-344835-iivry1ou	11	14	of	of	IN
cord-344835-iivry1ou	11	15	increased	increase	VBN
cord-344835-iivry1ou	11	16	airway	airway	NN
cord-344835-iivry1ou	11	17	inflammation	inflammation	NN
cord-344835-iivry1ou	11	18	and	and	CC
cord-344835-iivry1ou	11	19	COPD	COPD	NNP
cord-344835-iivry1ou	11	20	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	11	21	based	base	VBN
cord-344835-iivry1ou	11	22	on	on	IN
cord-344835-iivry1ou	11	23	recently	recently	RB
cord-344835-iivry1ou	11	24	published	publish	VBN
cord-344835-iivry1ou	11	25	data	datum	NNS
cord-344835-iivry1ou	11	26	.	.	.
cord-344835-iivry1ou	12	1	Although	although	IN
cord-344835-iivry1ou	12	2	it	-PRON-	PRP
cord-344835-iivry1ou	12	3	can	can	MD
cord-344835-iivry1ou	12	4	be	be	VB
cord-344835-iivry1ou	12	5	speculated	speculate	VBN
cord-344835-iivry1ou	12	6	that	that	IN
cord-344835-iivry1ou	12	7	reducing	reduce	VBG
cord-344835-iivry1ou	12	8	inflammation	inflammation	NN
cord-344835-iivry1ou	12	9	may	may	MD
cord-344835-iivry1ou	12	10	prevent	prevent	VB
cord-344835-iivry1ou	12	11	and/or	and/or	CC
cord-344835-iivry1ou	12	12	treat	treat	VB
cord-344835-iivry1ou	12	13	COPD	COPD	NNP
cord-344835-iivry1ou	12	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	12	15	,	,	,
cord-344835-iivry1ou	12	16	the	the	DT
cord-344835-iivry1ou	12	17	existing	exist	VBG
cord-344835-iivry1ou	12	18	anti	anti	JJ
cord-344835-iivry1ou	12	19	-	-	JJ
cord-344835-iivry1ou	12	20	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	12	21	treatments	treatment	NNS
cord-344835-iivry1ou	12	22	are	be	VBP
cord-344835-iivry1ou	12	23	modestly	modestly	RB
cord-344835-iivry1ou	12	24	effective	effective	JJ
cord-344835-iivry1ou	12	25	.	.	.
cord-344835-iivry1ou	13	1	Exacerbations	exacerbation	NNS
cord-344835-iivry1ou	13	2	are	be	VBP
cord-344835-iivry1ou	13	3	a	a	DT
cord-344835-iivry1ou	13	4	cardinal	cardinal	JJ
cord-344835-iivry1ou	13	5	feature	feature	NN
cord-344835-iivry1ou	13	6	of	of	IN
cord-344835-iivry1ou	13	7	the	the	DT
cord-344835-iivry1ou	13	8	natural	natural	JJ
cord-344835-iivry1ou	13	9	history	history	NN
cord-344835-iivry1ou	13	10	of	of	IN
cord-344835-iivry1ou	13	11	moderate	moderate	JJ
cord-344835-iivry1ou	13	12	and	and	CC
cord-344835-iivry1ou	13	13	severe	severe	JJ
cord-344835-iivry1ou	13	14	Chronic	Chronic	NNP
cord-344835-iivry1ou	13	15	Obstructive	obstructive	JJ
cord-344835-iivry1ou	13	16	Pulmonary	Pulmonary	NNP
cord-344835-iivry1ou	13	17	Disease	Disease	NNP
cord-344835-iivry1ou	13	18	(	(	-LRB-
cord-344835-iivry1ou	13	19	COPD	COPD	NNP
cord-344835-iivry1ou	13	20	)	)	-RRB-
cord-344835-iivry1ou	13	21	[	[	-LRB-
cord-344835-iivry1ou	13	22	1	1	CD
cord-344835-iivry1ou	13	23	]	]	-RRB-
cord-344835-iivry1ou	13	24	.	.	.
cord-344835-iivry1ou	14	1	Patients	patient	NNS
cord-344835-iivry1ou	14	2	with	with	IN
cord-344835-iivry1ou	14	3	frequent	frequent	JJ
cord-344835-iivry1ou	14	4	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	14	5	have	have	VBP
cord-344835-iivry1ou	14	6	significantly	significantly	RB
cord-344835-iivry1ou	14	7	lower	low	JJR
cord-344835-iivry1ou	14	8	quality	quality	NN
cord-344835-iivry1ou	14	9	of	of	IN
cord-344835-iivry1ou	14	10	life	life	NN
cord-344835-iivry1ou	14	11	and	and	CC
cord-344835-iivry1ou	14	12	increased	increase	VBN
cord-344835-iivry1ou	14	13	morbidity	morbidity	NN
cord-344835-iivry1ou	14	14	and	and	CC
cord-344835-iivry1ou	14	15	mortality	mortality	NN
cord-344835-iivry1ou	14	16	rates	rate	NNS
cord-344835-iivry1ou	14	17	[	[	-LRB-
cord-344835-iivry1ou	14	18	1	1	CD
cord-344835-iivry1ou	14	19	]	]	-RRB-
cord-344835-iivry1ou	14	20	[	[	-LRB-
cord-344835-iivry1ou	14	21	2	2	CD
cord-344835-iivry1ou	14	22	]	]	-RRB-
cord-344835-iivry1ou	14	23	[	[	-LRB-
cord-344835-iivry1ou	14	24	3	3	CD
cord-344835-iivry1ou	14	25	]	]	-RRB-
cord-344835-iivry1ou	14	26	[	[	-LRB-
cord-344835-iivry1ou	14	27	4	4	CD
cord-344835-iivry1ou	14	28	]	]	-RRB-
cord-344835-iivry1ou	14	29	.	.	.
cord-344835-iivry1ou	15	1	Although	although	IN
cord-344835-iivry1ou	15	2	the	the	DT
cord-344835-iivry1ou	15	3	effect	effect	NN
cord-344835-iivry1ou	15	4	of	of	IN
cord-344835-iivry1ou	15	5	COPD	COPD	NNP
cord-344835-iivry1ou	15	6	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	15	7	on	on	IN
cord-344835-iivry1ou	15	8	lung	lung	NN
cord-344835-iivry1ou	15	9	function	function	NN
cord-344835-iivry1ou	15	10	has	have	VBZ
cord-344835-iivry1ou	15	11	been	be	VBN
cord-344835-iivry1ou	15	12	questioned	question	VBN
cord-344835-iivry1ou	15	13	in	in	IN
cord-344835-iivry1ou	15	14	the	the	DT
cord-344835-iivry1ou	15	15	past	past	NN
cord-344835-iivry1ou	15	16	,	,	,
cord-344835-iivry1ou	15	17	recent	recent	JJ
cord-344835-iivry1ou	15	18	evidence	evidence	NN
cord-344835-iivry1ou	15	19	suggests	suggest	VBZ
cord-344835-iivry1ou	15	20	that	that	IN
cord-344835-iivry1ou	15	21	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	15	22	accelerate	accelerate	VBP
cord-344835-iivry1ou	15	23	long	long	JJ
cord-344835-iivry1ou	15	24	-	-	HYPH
cord-344835-iivry1ou	15	25	term	term	NN
cord-344835-iivry1ou	15	26	decline	decline	NN
cord-344835-iivry1ou	15	27	in	in	IN
cord-344835-iivry1ou	15	28	lung	lung	NN
cord-344835-iivry1ou	15	29	function	function	NN
cord-344835-iivry1ou	15	30	,	,	,
cord-344835-iivry1ou	15	31	specifically	specifically	RB
cord-344835-iivry1ou	15	32	in	in	IN
cord-344835-iivry1ou	15	33	smokers	smoker	NNS
cord-344835-iivry1ou	15	34	[	[	-LRB-
cord-344835-iivry1ou	15	35	5	5	CD
cord-344835-iivry1ou	15	36	]	]	-RRB-
cord-344835-iivry1ou	15	37	[	[	-LRB-
cord-344835-iivry1ou	15	38	6	6	CD
cord-344835-iivry1ou	15	39	]	]	-RRB-
cord-344835-iivry1ou	15	40	[	[	-LRB-
cord-344835-iivry1ou	15	41	7	7	CD
cord-344835-iivry1ou	15	42	]	]	-RRB-
cord-344835-iivry1ou	15	43	.	.	.
cord-344835-iivry1ou	16	1	The	the	DT
cord-344835-iivry1ou	16	2	mechanism	mechanism	NN
cord-344835-iivry1ou	16	3	of	of	IN
cord-344835-iivry1ou	16	4	this	this	DT
cord-344835-iivry1ou	16	5	acceleration	acceleration	NN
cord-344835-iivry1ou	16	6	remains	remain	VBZ
cord-344835-iivry1ou	16	7	largely	largely	RB
cord-344835-iivry1ou	16	8	unknown	unknown	JJ
cord-344835-iivry1ou	16	9	.	.	.
cord-344835-iivry1ou	17	1	Treatment	treatment	NN
cord-344835-iivry1ou	17	2	decisions	decision	NNS
cord-344835-iivry1ou	17	3	for	for	IN
cord-344835-iivry1ou	17	4	COPD	COPD	NNP
cord-344835-iivry1ou	17	5	patients	patient	NNS
cord-344835-iivry1ou	17	6	are	be	VBP
cord-344835-iivry1ou	17	7	frequently	frequently	RB
cord-344835-iivry1ou	17	8	made	make	VBN
cord-344835-iivry1ou	17	9	according	accord	VBG
cord-344835-iivry1ou	17	10	to	to	IN
cord-344835-iivry1ou	17	11	exacerbation	exacerbation	NN
cord-344835-iivry1ou	17	12	rates	rate	NNS
cord-344835-iivry1ou	17	13	.	.	.
cord-344835-iivry1ou	18	1	In	in	IN
cord-344835-iivry1ou	18	2	the	the	DT
cord-344835-iivry1ou	18	3	ATS	ATS	NNP
cord-344835-iivry1ou	18	4	/	/	SYM
cord-344835-iivry1ou	18	5	ERS	ERS	NNP
cord-344835-iivry1ou	18	6	guidelines	guideline	NNS
cord-344835-iivry1ou	18	7	it	-PRON-	PRP
cord-344835-iivry1ou	18	8	is	be	VBZ
cord-344835-iivry1ou	18	9	stated	state	VBN
cord-344835-iivry1ou	18	10	that	that	IN
cord-344835-iivry1ou	18	11	patients	patient	NNS
cord-344835-iivry1ou	18	12	with	with	IN
cord-344835-iivry1ou	18	13	frequent	frequent	JJ
cord-344835-iivry1ou	18	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	18	15	should	should	MD
cord-344835-iivry1ou	18	16	be	be	VB
cord-344835-iivry1ou	18	17	initiated	initiate	VBN
cord-344835-iivry1ou	18	18	a	a	DT
cord-344835-iivry1ou	18	19	trial	trial	NN
cord-344835-iivry1ou	18	20	of	of	IN
cord-344835-iivry1ou	18	21	inhaled	inhale	VBN
cord-344835-iivry1ou	18	22	steroids	steroid	NNS
cord-344835-iivry1ou	18	23	[	[	-LRB-
cord-344835-iivry1ou	18	24	8	8	CD
cord-344835-iivry1ou	18	25	]	]	-RRB-
cord-344835-iivry1ou	18	26	.	.	.
cord-344835-iivry1ou	19	1	Systemic	systemic	JJ
cord-344835-iivry1ou	19	2	steroids	steroid	NNS
cord-344835-iivry1ou	19	3	should	should	MD
cord-344835-iivry1ou	19	4	be	be	VB
cord-344835-iivry1ou	19	5	administered	administer	VBN
cord-344835-iivry1ou	19	6	during	during	IN
cord-344835-iivry1ou	19	7	acute	acute	JJ
cord-344835-iivry1ou	19	8	COPD	COPD	NNP
cord-344835-iivry1ou	19	9	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	19	10	,	,	,
cord-344835-iivry1ou	19	11	both	both	CC
cord-344835-iivry1ou	19	12	in	in	IN
cord-344835-iivry1ou	19	13	the	the	DT
cord-344835-iivry1ou	19	14	inpatient	inpatient	JJ
cord-344835-iivry1ou	19	15	and	and	CC
cord-344835-iivry1ou	19	16	outpatient	outpatient	NN
cord-344835-iivry1ou	19	17	setting	setting	NN
cord-344835-iivry1ou	19	18	.	.	.
cord-344835-iivry1ou	20	1	These	these	DT
cord-344835-iivry1ou	20	2	treatment	treatment	NN
cord-344835-iivry1ou	20	3	strategies	strategy	NNS
cord-344835-iivry1ou	20	4	indicate	indicate	VBP
cord-344835-iivry1ou	20	5	the	the	DT
cord-344835-iivry1ou	20	6	central	central	JJ
cord-344835-iivry1ou	20	7	role	role	NN
cord-344835-iivry1ou	20	8	of	of	IN
cord-344835-iivry1ou	20	9	inflammation	inflammation	NN
cord-344835-iivry1ou	20	10	in	in	IN
cord-344835-iivry1ou	20	11	the	the	DT
cord-344835-iivry1ou	20	12	pathogenesis	pathogenesis	NN
cord-344835-iivry1ou	20	13	of	of	IN
cord-344835-iivry1ou	20	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	20	15	.	.	.
cord-344835-iivry1ou	21	1	Although	although	IN
cord-344835-iivry1ou	21	2	evidence	evidence	NN
cord-344835-iivry1ou	21	3	for	for	IN
cord-344835-iivry1ou	21	4	increased	increased	JJ
cord-344835-iivry1ou	21	5	inflammation	inflammation	NN
cord-344835-iivry1ou	21	6	on	on	IN
cord-344835-iivry1ou	21	7	COPD	COPD	NNP
cord-344835-iivry1ou	21	8	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	21	9	has	have	VBZ
cord-344835-iivry1ou	21	10	been	be	VBN
cord-344835-iivry1ou	21	11	reviewed	review	VBN
cord-344835-iivry1ou	21	12	previously	previously	RB
cord-344835-iivry1ou	21	13	,	,	,
cord-344835-iivry1ou	21	14	there	there	EX
cord-344835-iivry1ou	21	15	has	have	VBZ
cord-344835-iivry1ou	21	16	been	be	VBN
cord-344835-iivry1ou	21	17	little	little	JJ
cord-344835-iivry1ou	21	18	focus	focus	NN
cord-344835-iivry1ou	21	19	on	on	IN
cord-344835-iivry1ou	21	20	why	why	WRB
cord-344835-iivry1ou	21	21	inflammation	inflammation	NN
cord-344835-iivry1ou	21	22	increases	increase	NNS
cord-344835-iivry1ou	21	23	and	and	CC
cord-344835-iivry1ou	22	1	which	which	WDT
cord-344835-iivry1ou	22	2	the	the	DT
cord-344835-iivry1ou	22	3	consequences	consequence	NNS
cord-344835-iivry1ou	22	4	of	of	IN
cord-344835-iivry1ou	22	5	this	this	DT
cord-344835-iivry1ou	22	6	increase	increase	NN
cord-344835-iivry1ou	22	7	are	be	VBP
cord-344835-iivry1ou	22	8	[	[	-LRB-
cord-344835-iivry1ou	22	9	9	9	CD
cord-344835-iivry1ou	22	10	,	,	,
cord-344835-iivry1ou	22	11	10	10	CD
cord-344835-iivry1ou	22	12	]	]	-RRB-
cord-344835-iivry1ou	22	13	.	.	.
cord-344835-iivry1ou	23	1	Investigating	investigate	VBG
cord-344835-iivry1ou	23	2	further	further	RB
cord-344835-iivry1ou	23	3	these	these	DT
cord-344835-iivry1ou	23	4	important	important	JJ
cord-344835-iivry1ou	23	5	questions	question	NNS
cord-344835-iivry1ou	23	6	may	may	MD
cord-344835-iivry1ou	23	7	help	help	VB
cord-344835-iivry1ou	23	8	establish	establish	VB
cord-344835-iivry1ou	23	9	a	a	DT
cord-344835-iivry1ou	23	10	cause	cause	NN
cord-344835-iivry1ou	23	11	and	and	CC
cord-344835-iivry1ou	23	12	effect	effect	NN
cord-344835-iivry1ou	23	13	relationship	relationship	NN
cord-344835-iivry1ou	23	14	between	between	IN
cord-344835-iivry1ou	23	15	inflammation	inflammation	NN
cord-344835-iivry1ou	23	16	and	and	CC
cord-344835-iivry1ou	23	17	COPD	COPD	NNP
cord-344835-iivry1ou	23	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	23	19	.	.	.
cord-344835-iivry1ou	24	1	The	the	DT
cord-344835-iivry1ou	24	2	primary	primary	JJ
cord-344835-iivry1ou	24	3	aim	aim	NN
cord-344835-iivry1ou	24	4	of	of	IN
cord-344835-iivry1ou	24	5	this	this	DT
cord-344835-iivry1ou	24	6	review	review	NN
cord-344835-iivry1ou	24	7	is	be	VBZ
cord-344835-iivry1ou	24	8	to	to	TO
cord-344835-iivry1ou	24	9	summarize	summarize	VB
cord-344835-iivry1ou	24	10	emerging	emerge	VBG
cord-344835-iivry1ou	24	11	explanations	explanation	NNS
cord-344835-iivry1ou	24	12	for	for	IN
cord-344835-iivry1ou	24	13	why	why	WRB
cord-344835-iivry1ou	24	14	inflammation	inflammation	NN
cord-344835-iivry1ou	24	15	is	be	VBZ
cord-344835-iivry1ou	24	16	increased	increase	VBN
cord-344835-iivry1ou	24	17	during	during	IN
cord-344835-iivry1ou	24	18	COPD	COPD	NNP
cord-344835-iivry1ou	24	19	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	24	20	.	.	.
cord-344835-iivry1ou	25	1	For	for	IN
cord-344835-iivry1ou	25	2	practical	practical	JJ
cord-344835-iivry1ou	25	3	purposes	purpose	NNS
cord-344835-iivry1ou	25	4	an	an	DT
cord-344835-iivry1ou	25	5	attempt	attempt	NN
cord-344835-iivry1ou	25	6	is	be	VBZ
cord-344835-iivry1ou	25	7	made	make	VBN
cord-344835-iivry1ou	25	8	to	to	TO
cord-344835-iivry1ou	25	9	categorize	categorize	VB
cord-344835-iivry1ou	25	10	aetiological	aetiological	JJ
cord-344835-iivry1ou	25	11	factors	factor	NNS
cord-344835-iivry1ou	25	12	of	of	IN
cord-344835-iivry1ou	25	13	increased	increase	VBN
cord-344835-iivry1ou	25	14	inflammation	inflammation	NN
cord-344835-iivry1ou	25	15	into	into	IN
cord-344835-iivry1ou	25	16	extrinsic	extrinsic	JJ
cord-344835-iivry1ou	25	17	or	or	CC
cord-344835-iivry1ou	25	18	intrinsic	intrinsic	JJ
cord-344835-iivry1ou	25	19	,	,	,
cord-344835-iivry1ou	25	20	as	as	IN
cord-344835-iivry1ou	25	21	it	-PRON-	PRP
cord-344835-iivry1ou	25	22	can	can	MD
cord-344835-iivry1ou	25	23	be	be	VB
cord-344835-iivry1ou	25	24	seen	see	VBN
cord-344835-iivry1ou	25	25	in	in	IN
cord-344835-iivry1ou	25	26	table	table	NN
cord-344835-iivry1ou	25	27	1	1	CD
cord-344835-iivry1ou	25	28	.	.	.
cord-344835-iivry1ou	26	1	A	a	DT
cord-344835-iivry1ou	26	2	secondary	secondary	JJ
cord-344835-iivry1ou	26	3	aim	aim	NN
cord-344835-iivry1ou	26	4	is	be	VBZ
cord-344835-iivry1ou	26	5	to	to	TO
cord-344835-iivry1ou	26	6	try	try	VB
cord-344835-iivry1ou	26	7	to	to	TO
cord-344835-iivry1ou	26	8	explain	explain	VB
cord-344835-iivry1ou	26	9	how	how	WRB
cord-344835-iivry1ou	26	10	increased	increased	JJ
cord-344835-iivry1ou	26	11	inflammation	inflammation	NN
cord-344835-iivry1ou	26	12	is	be	VBZ
cord-344835-iivry1ou	26	13	associated	associate	VBN
cord-344835-iivry1ou	26	14	with	with	IN
cord-344835-iivry1ou	26	15	the	the	DT
cord-344835-iivry1ou	26	16	pathophysiology	pathophysiology	NN
cord-344835-iivry1ou	26	17	of	of	IN
cord-344835-iivry1ou	26	18	COPD	COPD	NNP
cord-344835-iivry1ou	26	19	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	26	20	.	.	.
cord-344835-iivry1ou	27	1	Bacterial	bacterial	JJ
cord-344835-iivry1ou	27	2	infections	infection	NNS
cord-344835-iivry1ou	27	3	are	be	VBP
cord-344835-iivry1ou	27	4	generally	generally	RB
cord-344835-iivry1ou	27	5	considered	consider	VBN
cord-344835-iivry1ou	27	6	to	to	TO
cord-344835-iivry1ou	27	7	be	be	VB
cord-344835-iivry1ou	27	8	the	the	DT
cord-344835-iivry1ou	27	9	most	most	RBS
cord-344835-iivry1ou	27	10	common	common	JJ
cord-344835-iivry1ou	27	11	causes	cause	NNS
cord-344835-iivry1ou	27	12	of	of	IN
cord-344835-iivry1ou	27	13	COPD	COPD	NNP
cord-344835-iivry1ou	27	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	27	15	.	.	.
cord-344835-iivry1ou	28	1	It	-PRON-	PRP
cord-344835-iivry1ou	28	2	is	be	VBZ
cord-344835-iivry1ou	28	3	estimated	estimate	VBN
cord-344835-iivry1ou	28	4	that	that	IN
cord-344835-iivry1ou	28	5	more	more	JJR
cord-344835-iivry1ou	28	6	than	than	IN
cord-344835-iivry1ou	28	7	40	40	CD
cord-344835-iivry1ou	28	8	%	%	NN
cord-344835-iivry1ou	28	9	of	of	IN
cord-344835-iivry1ou	28	10	all	all	DT
cord-344835-iivry1ou	28	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	28	12	are	be	VBP
cord-344835-iivry1ou	28	13	of	of	IN
cord-344835-iivry1ou	28	14	bacterial	bacterial	JJ
cord-344835-iivry1ou	28	15	origin	origin	NN
cord-344835-iivry1ou	28	16	[	[	-LRB-
cord-344835-iivry1ou	28	17	9	9	CD
cord-344835-iivry1ou	28	18	,	,	,
cord-344835-iivry1ou	28	19	11	11	CD
cord-344835-iivry1ou	28	20	,	,	,
cord-344835-iivry1ou	28	21	12	12	CD
cord-344835-iivry1ou	28	22	]	]	-RRB-
cord-344835-iivry1ou	28	23	.	.	.
cord-344835-iivry1ou	29	1	Accordingly	accordingly	RB
cord-344835-iivry1ou	29	2	,	,	,
cord-344835-iivry1ou	29	3	antibiotics	antibiotic	NNS
cord-344835-iivry1ou	29	4	should	should	MD
cord-344835-iivry1ou	29	5	be	be	VB
cord-344835-iivry1ou	29	6	administered	administer	VBN
cord-344835-iivry1ou	29	7	in	in	IN
cord-344835-iivry1ou	29	8	inpatients	inpatient	NNS
cord-344835-iivry1ou	29	9	and	and	CC
cord-344835-iivry1ou	29	10	outpatients	outpatient	NNS
cord-344835-iivry1ou	29	11	with	with	IN
cord-344835-iivry1ou	29	12	acute	acute	JJ
cord-344835-iivry1ou	29	13	COPD	COPD	NNP
cord-344835-iivry1ou	29	14	exacerbation	exacerbation	NN
cord-344835-iivry1ou	29	15	and	and	CC
cord-344835-iivry1ou	29	16	changes	change	NNS
cord-344835-iivry1ou	29	17	in	in	IN
cord-344835-iivry1ou	29	18	sputum	sputum	NN
cord-344835-iivry1ou	29	19	characteristics	characteristic	NNS
cord-344835-iivry1ou	29	20	suggestive	suggestive	JJ
cord-344835-iivry1ou	29	21	of	of	IN
cord-344835-iivry1ou	29	22	bacterial	bacterial	JJ
cord-344835-iivry1ou	29	23	infection	infection	NN
cord-344835-iivry1ou	29	24	[	[	-LRB-
cord-344835-iivry1ou	29	25	8	8	CD
cord-344835-iivry1ou	29	26	]	]	-RRB-
cord-344835-iivry1ou	29	27	.	.	.
cord-344835-iivry1ou	30	1	The	the	DT
cord-344835-iivry1ou	30	2	most	most	RBS
cord-344835-iivry1ou	30	3	common	common	JJ
cord-344835-iivry1ou	30	4	bacteria	bacteria	NNS
cord-344835-iivry1ou	30	5	connected	connect	VBN
cord-344835-iivry1ou	30	6	to	to	IN
cord-344835-iivry1ou	30	7	COPD	COPD	NNP
cord-344835-iivry1ou	30	8	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	30	9	are	be	VBP
cord-344835-iivry1ou	30	10	non	non	JJ
cord-344835-iivry1ou	30	11	-	-	JJ
cord-344835-iivry1ou	30	12	typable	typable	JJ
cord-344835-iivry1ou	30	13	H.	H.	NNP
cord-344835-iivry1ou	30	14	Influenzae	Influenzae	NNP
cord-344835-iivry1ou	30	15	,	,	,
cord-344835-iivry1ou	30	16	S.	S.	NNP
cord-344835-iivry1ou	30	17	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	30	18	,	,	,
cord-344835-iivry1ou	30	19	and	and	CC
cord-344835-iivry1ou	30	20	M.	M.	NNP
cord-344835-iivry1ou	30	21	Cattarhalis	Cattarhalis	NNP
cord-344835-iivry1ou	30	22	[	[	-LRB-
cord-344835-iivry1ou	30	23	9	9	CD
cord-344835-iivry1ou	30	24	,	,	,
cord-344835-iivry1ou	30	25	11	11	CD
cord-344835-iivry1ou	30	26	,	,	,
cord-344835-iivry1ou	30	27	12	12	CD
cord-344835-iivry1ou	30	28	]	]	-RRB-
cord-344835-iivry1ou	30	29	.	.	.
cord-344835-iivry1ou	31	1	The	the	DT
cord-344835-iivry1ou	31	2	same	same	JJ
cord-344835-iivry1ou	31	3	bacteria	bacteria	NNS
cord-344835-iivry1ou	31	4	often	often	RB
cord-344835-iivry1ou	31	5	colonize	colonize	VBP
cord-344835-iivry1ou	31	6	the	the	DT
cord-344835-iivry1ou	31	7	nasal	nasal	NN
cord-344835-iivry1ou	31	8	mucosa	mucosa	JJ
cord-344835-iivry1ou	31	9	and	and	CC
cord-344835-iivry1ou	31	10	pharynx	pharynx	NN
cord-344835-iivry1ou	31	11	of	of	IN
cord-344835-iivry1ou	31	12	healthy	healthy	JJ
cord-344835-iivry1ou	31	13	individuals	individual	NNS
cord-344835-iivry1ou	31	14	,	,	,
cord-344835-iivry1ou	31	15	but	but	CC
cord-344835-iivry1ou	31	16	in	in	IN
cord-344835-iivry1ou	31	17	smokers	smoker	NNS
cord-344835-iivry1ou	31	18	and	and	CC
cord-344835-iivry1ou	31	19	in	in	IN
cord-344835-iivry1ou	31	20	patients	patient	NNS
cord-344835-iivry1ou	31	21	with	with	IN
cord-344835-iivry1ou	31	22	COPD	COPD	NNP
cord-344835-iivry1ou	31	23	impaired	impair	VBN
cord-344835-iivry1ou	31	24	mucocilliary	mucocilliary	JJ
cord-344835-iivry1ou	31	25	clearance	clearance	NN
cord-344835-iivry1ou	31	26	and	and	CC
cord-344835-iivry1ou	31	27	innate	innate	JJ
cord-344835-iivry1ou	31	28	immunity	immunity	NN
cord-344835-iivry1ou	31	29	allow	allow	VBP
cord-344835-iivry1ou	31	30	these	these	DT
cord-344835-iivry1ou	31	31	pathogens	pathogen	NNS
cord-344835-iivry1ou	31	32	to	to	TO
cord-344835-iivry1ou	31	33	colonize	colonize	VB
cord-344835-iivry1ou	31	34	the	the	DT
cord-344835-iivry1ou	31	35	lower	low	JJR
cord-344835-iivry1ou	31	36	airways	airway	NNS
cord-344835-iivry1ou	31	37	[	[	-LRB-
cord-344835-iivry1ou	31	38	13	13	CD
cord-344835-iivry1ou	31	39	]	]	-RRB-
cord-344835-iivry1ou	31	40	.	.	.
cord-344835-iivry1ou	32	1	COPD	COPD	NNP
cord-344835-iivry1ou	32	2	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	32	3	may	may	MD
cord-344835-iivry1ou	32	4	be	be	VB
cord-344835-iivry1ou	32	5	triggered	trigger	VBN
cord-344835-iivry1ou	32	6	by	by	IN
cord-344835-iivry1ou	32	7	the	the	DT
cord-344835-iivry1ou	32	8	acquisition	acquisition	NN
cord-344835-iivry1ou	32	9	of	of	IN
cord-344835-iivry1ou	32	10	a	a	DT
cord-344835-iivry1ou	32	11	new	new	JJ
cord-344835-iivry1ou	32	12	bacterial	bacterial	JJ
cord-344835-iivry1ou	32	13	species	specie	NNS
cord-344835-iivry1ou	32	14	or	or	CC
cord-344835-iivry1ou	32	15	by	by	IN
cord-344835-iivry1ou	32	16	an	an	DT
cord-344835-iivry1ou	32	17	increase	increase	NN
cord-344835-iivry1ou	32	18	in	in	IN
cord-344835-iivry1ou	32	19	the	the	DT
cord-344835-iivry1ou	32	20	absolute	absolute	JJ
cord-344835-iivry1ou	32	21	number	number	NN
cord-344835-iivry1ou	32	22	of	of	IN
cord-344835-iivry1ou	32	23	the	the	DT
cord-344835-iivry1ou	32	24	same	same	JJ
cord-344835-iivry1ou	32	25	bacteria	bacteria	NNS
cord-344835-iivry1ou	32	26	that	that	WDT
cord-344835-iivry1ou	32	27	colonize	colonize	VBP
cord-344835-iivry1ou	32	28	the	the	DT
cord-344835-iivry1ou	32	29	airways	airway	NNS
cord-344835-iivry1ou	32	30	or	or	CC
cord-344835-iivry1ou	32	31	by	by	IN
cord-344835-iivry1ou	32	32	the	the	DT
cord-344835-iivry1ou	32	33	acquisition	acquisition	NN
cord-344835-iivry1ou	32	34	of	of	IN
cord-344835-iivry1ou	32	35	a	a	DT
cord-344835-iivry1ou	32	36	different	different	JJ
cord-344835-iivry1ou	32	37	strain	strain	NN
cord-344835-iivry1ou	32	38	from	from	IN
cord-344835-iivry1ou	32	39	the	the	DT
cord-344835-iivry1ou	32	40	same	same	JJ
cord-344835-iivry1ou	32	41	bacterial	bacterial	JJ
cord-344835-iivry1ou	32	42	species	specie	NNS
cord-344835-iivry1ou	32	43	[	[	-LRB-
cord-344835-iivry1ou	32	44	14	14	CD
cord-344835-iivry1ou	32	45	]	]	-RRB-
cord-344835-iivry1ou	32	46	[	[	-LRB-
cord-344835-iivry1ou	32	47	15	15	CD
cord-344835-iivry1ou	32	48	]	]	-RRB-
cord-344835-iivry1ou	32	49	[	[	-LRB-
cord-344835-iivry1ou	32	50	16	16	CD
cord-344835-iivry1ou	32	51	]	]	-RRB-
cord-344835-iivry1ou	32	52	.	.	.
cord-344835-iivry1ou	33	1	Airway	airway	NN
cord-344835-iivry1ou	33	2	bacteria	bacteria	NNS
cord-344835-iivry1ou	33	3	initiate	initiate	VBP
cord-344835-iivry1ou	33	4	airway	airway	NN
cord-344835-iivry1ou	33	5	inflammation	inflammation	NN
cord-344835-iivry1ou	33	6	through	through	IN
cord-344835-iivry1ou	33	7	several	several	JJ
cord-344835-iivry1ou	33	8	interconnecting	interconnect	VBG
cord-344835-iivry1ou	33	9	mechanisms	mechanism	NNS
cord-344835-iivry1ou	33	10	.	.	.
cord-344835-iivry1ou	34	1	The	the	DT
cord-344835-iivry1ou	34	2	surface	surface	NN
cord-344835-iivry1ou	34	3	of	of	IN
cord-344835-iivry1ou	34	4	bacteria	bacteria	NNS
cord-344835-iivry1ou	34	5	allows	allow	VBZ
cord-344835-iivry1ou	34	6	the	the	DT
cord-344835-iivry1ou	34	7	complement	complement	JJ
cord-344835-iivry1ou	34	8	system	system	NN
cord-344835-iivry1ou	34	9	to	to	TO
cord-344835-iivry1ou	34	10	be	be	VB
cord-344835-iivry1ou	34	11	activated	activate	VBN
cord-344835-iivry1ou	34	12	through	through	IN
cord-344835-iivry1ou	34	13	the	the	DT
cord-344835-iivry1ou	34	14	alternative	alternative	JJ
cord-344835-iivry1ou	34	15	pathway	pathway	NN
cord-344835-iivry1ou	34	16	,	,	,
cord-344835-iivry1ou	34	17	while	while	IN
cord-344835-iivry1ou	34	18	specific	specific	JJ
cord-344835-iivry1ou	34	19	surface	surface	NN
cord-344835-iivry1ou	34	20	molecules	molecule	NNS
cord-344835-iivry1ou	34	21	of	of	IN
cord-344835-iivry1ou	34	22	the	the	DT
cord-344835-iivry1ou	34	23	bacteria	bacteria	NNS
cord-344835-iivry1ou	34	24	,	,	,
cord-344835-iivry1ou	34	25	called	call	VBN
cord-344835-iivry1ou	34	26	Pathogen	Pathogen	NNP
cord-344835-iivry1ou	34	27	-	-	HYPH
cord-344835-iivry1ou	34	28	Associated	Associated	NNP
cord-344835-iivry1ou	34	29	Molecular	Molecular	NNP
cord-344835-iivry1ou	34	30	Patterns	pattern	NNS
cord-344835-iivry1ou	34	31	(	(	-LRB-
cord-344835-iivry1ou	34	32	PAMPs	pamp	NNS
cord-344835-iivry1ou	34	33	)	)	-RRB-
cord-344835-iivry1ou	34	34	,	,	,
cord-344835-iivry1ou	34	35	bind	bind	VB
cord-344835-iivry1ou	34	36	to	to	IN
cord-344835-iivry1ou	34	37	pattern	pattern	NN
cord-344835-iivry1ou	34	38	recognition	recognition	NN
cord-344835-iivry1ou	34	39	receptors	receptor	NNS
cord-344835-iivry1ou	34	40	on	on	IN
cord-344835-iivry1ou	34	41	a	a	DT
cord-344835-iivry1ou	34	42	variety	variety	NN
cord-344835-iivry1ou	34	43	of	of	IN
cord-344835-iivry1ou	34	44	leukocytes	leukocyte	NNS
cord-344835-iivry1ou	34	45	and	and	CC
cord-344835-iivry1ou	34	46	initiate	initiate	VB
cord-344835-iivry1ou	34	47	signalling	signal	VBG
cord-344835-iivry1ou	34	48	pathways	pathway	NNS
cord-344835-iivry1ou	34	49	that	that	WDT
cord-344835-iivry1ou	34	50	lead	lead	VBP
cord-344835-iivry1ou	34	51	to	to	IN
cord-344835-iivry1ou	34	52	the	the	DT
cord-344835-iivry1ou	34	53	activation	activation	NN
cord-344835-iivry1ou	34	54	of	of	IN
cord-344835-iivry1ou	34	55	NF	nf	NN
cord-344835-iivry1ou	34	56	-	-	HYPH
cord-344835-iivry1ou	34	57	κB	κb	NN
cord-344835-iivry1ou	34	58	and	and	CC
cord-344835-iivry1ou	34	59	production	production	NN
cord-344835-iivry1ou	34	60	of	of	IN
cord-344835-iivry1ou	34	61	proinflammatory	proinflammatory	JJ
cord-344835-iivry1ou	34	62	cytokines	cytokine	NNS
cord-344835-iivry1ou	34	63	[	[	-LRB-
cord-344835-iivry1ou	34	64	17	17	CD
cord-344835-iivry1ou	34	65	]	]	-RRB-
cord-344835-iivry1ou	34	66	.	.	.
cord-344835-iivry1ou	35	1	Once	once	RB
cord-344835-iivry1ou	35	2	activated	activate	VBN
cord-344835-iivry1ou	35	3	,	,	,
cord-344835-iivry1ou	35	4	innate	innate	JJ
cord-344835-iivry1ou	35	5	immunity	immunity	NN
cord-344835-iivry1ou	35	6	can	can	MD
cord-344835-iivry1ou	35	7	trigger	trigger	VB
cord-344835-iivry1ou	35	8	both	both	DT
cord-344835-iivry1ou	35	9	cell	cell	NN
cord-344835-iivry1ou	35	10	-	-	HYPH
cord-344835-iivry1ou	35	11	mediated	mediate	VBN
cord-344835-iivry1ou	35	12	and	and	CC
cord-344835-iivry1ou	35	13	antibodymediated	antibodymediated	JJ
cord-344835-iivry1ou	35	14	adaptive	adaptive	JJ
cord-344835-iivry1ou	35	15	immune	immune	JJ
cord-344835-iivry1ou	35	16	responses	response	NNS
cord-344835-iivry1ou	35	17	.	.	.
cord-344835-iivry1ou	36	1	This	this	DT
cord-344835-iivry1ou	36	2	cascade	cascade	NN
cord-344835-iivry1ou	36	3	of	of	IN
cord-344835-iivry1ou	36	4	events	event	NNS
cord-344835-iivry1ou	36	5	leads	lead	VBZ
cord-344835-iivry1ou	36	6	to	to	IN
cord-344835-iivry1ou	36	7	increased	increase	VBN
cord-344835-iivry1ou	36	8	blood	blood	NN
cord-344835-iivry1ou	36	9	flow	flow	NN
cord-344835-iivry1ou	36	10	to	to	IN
cord-344835-iivry1ou	36	11	tissue	tissue	NN
cord-344835-iivry1ou	36	12	,	,	,
cord-344835-iivry1ou	36	13	increased	increase	VBN
cord-344835-iivry1ou	36	14	temperature	temperature	NN
cord-344835-iivry1ou	36	15	,	,	,
cord-344835-iivry1ou	36	16	redness	redness	NN
cord-344835-iivry1ou	36	17	and	and	CC
cord-344835-iivry1ou	36	18	swelling	swelling	NN
cord-344835-iivry1ou	36	19	which	which	WDT
cord-344835-iivry1ou	36	20	characterize	characterize	VBP
cord-344835-iivry1ou	36	21	inflammation	inflammation	NN
cord-344835-iivry1ou	36	22	.	.	.
cord-344835-iivry1ou	37	1	A	a	DT
cord-344835-iivry1ou	37	2	significant	significant	JJ
cord-344835-iivry1ou	37	3	number	number	NN
cord-344835-iivry1ou	37	4	of	of	IN
cord-344835-iivry1ou	37	5	studies	study	NNS
cord-344835-iivry1ou	37	6	in	in	IN
cord-344835-iivry1ou	37	7	stable	stable	JJ
cord-344835-iivry1ou	37	8	COPD	COPD	NNP
cord-344835-iivry1ou	37	9	patients	patient	NNS
cord-344835-iivry1ou	37	10	suggest	suggest	VBP
cord-344835-iivry1ou	37	11	that	that	IN
cord-344835-iivry1ou	37	12	airway	airway	JJ
cord-344835-iivry1ou	37	13	bacterial	bacterial	JJ
cord-344835-iivry1ou	37	14	infections	infection	NNS
cord-344835-iivry1ou	37	15	are	be	VBP
cord-344835-iivry1ou	37	16	associated	associate	VBN
cord-344835-iivry1ou	37	17	with	with	IN
cord-344835-iivry1ou	37	18	increased	increase	VBN
cord-344835-iivry1ou	37	19	airway	airway	NN
cord-344835-iivry1ou	37	20	inflammation	inflammation	NN
cord-344835-iivry1ou	37	21	(	(	-LRB-
cord-344835-iivry1ou	37	22	18	18	CD
cord-344835-iivry1ou	37	23	)	)	-RRB-
cord-344835-iivry1ou	37	24	(	(	-LRB-
cord-344835-iivry1ou	37	25	19	19	CD
cord-344835-iivry1ou	37	26	)	)	-RRB-
cord-344835-iivry1ou	37	27	(	(	-LRB-
cord-344835-iivry1ou	37	28	20	20	CD
cord-344835-iivry1ou	37	29	)	)	-RRB-
cord-344835-iivry1ou	37	30	(	(	-LRB-
cord-344835-iivry1ou	37	31	21	21	CD
cord-344835-iivry1ou	37	32	)	)	-RRB-
cord-344835-iivry1ou	37	33	.	.	.
cord-344835-iivry1ou	38	1	Finding	find	VBG
cord-344835-iivry1ou	38	2	a	a	DT
cord-344835-iivry1ou	38	3	relationship	relationship	NN
cord-344835-iivry1ou	38	4	between	between	IN
cord-344835-iivry1ou	38	5	bacteria	bacteria	NNS
cord-344835-iivry1ou	38	6	and	and	CC
cord-344835-iivry1ou	38	7	inflammation	inflammation	NN
cord-344835-iivry1ou	38	8	on	on	IN
cord-344835-iivry1ou	38	9	stable	stable	JJ
cord-344835-iivry1ou	38	10	COPD	COPD	NNP
cord-344835-iivry1ou	38	11	adds	add	VBZ
cord-344835-iivry1ou	38	12	weight	weight	NN
cord-344835-iivry1ou	38	13	to	to	IN
cord-344835-iivry1ou	38	14	the	the	DT
cord-344835-iivry1ou	38	15	argument	argument	NN
cord-344835-iivry1ou	38	16	that	that	IN
cord-344835-iivry1ou	38	17	bacteria	bacteria	NNS
cord-344835-iivry1ou	38	18	may	may	MD
cord-344835-iivry1ou	38	19	play	play	VB
cord-344835-iivry1ou	38	20	a	a	DT
cord-344835-iivry1ou	38	21	causative	causative	JJ
cord-344835-iivry1ou	38	22	role	role	NN
cord-344835-iivry1ou	38	23	in	in	IN
cord-344835-iivry1ou	38	24	airway	airway	NN
cord-344835-iivry1ou	38	25	inflammation	inflammation	NN
cord-344835-iivry1ou	38	26	during	during	IN
cord-344835-iivry1ou	38	27	COPD	COPD	NNP
cord-344835-iivry1ou	38	28	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	38	29	.	.	.
cord-344835-iivry1ou	39	1	Soler	Soler	NNP
cord-344835-iivry1ou	39	2	et	et	NNP
cord-344835-iivry1ou	39	3	al	al	NNP
cord-344835-iivry1ou	39	4	used	use	VBD
cord-344835-iivry1ou	39	5	protected	protect	VBN
cord-344835-iivry1ou	39	6	specimen	specimen	JJ
cord-344835-iivry1ou	39	7	brush	brush	NN
cord-344835-iivry1ou	39	8	and	and	CC
cord-344835-iivry1ou	39	9	bronchoalveolar	bronchoalveolar	NNP
cord-344835-iivry1ou	39	10	lavage	lavage	NN
cord-344835-iivry1ou	39	11	sampling	sampling	NN
cord-344835-iivry1ou	39	12	to	to	TO
cord-344835-iivry1ou	39	13	determine	determine	VB
cord-344835-iivry1ou	39	14	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	39	15	cell	cell	NN
cord-344835-iivry1ou	39	16	counts	count	NNS
cord-344835-iivry1ou	39	17	,	,	,
cord-344835-iivry1ou	39	18	levels	level	NNS
cord-344835-iivry1ou	39	19	of	of	IN
cord-344835-iivry1ou	39	20	cytokines	cytokine	NNS
cord-344835-iivry1ou	39	21	concentrations	concentration	NNS
cord-344835-iivry1ou	39	22	and	and	CC
cord-344835-iivry1ou	39	23	microbial	microbial	JJ
cord-344835-iivry1ou	39	24	patterns	pattern	NNS
cord-344835-iivry1ou	39	25	in	in	IN
cord-344835-iivry1ou	39	26	stable	stable	JJ
cord-344835-iivry1ou	39	27	COPD	COPD	NNP
cord-344835-iivry1ou	39	28	patients	patient	NNS
cord-344835-iivry1ou	39	29	and	and	CC
cord-344835-iivry1ou	39	30	found	find	VBD
cord-344835-iivry1ou	39	31	that	that	IN
cord-344835-iivry1ou	39	32	increased	increase	VBN
cord-344835-iivry1ou	39	33	neutrophils	neutrophil	NNS
cord-344835-iivry1ou	39	34	and	and	CC
cord-344835-iivry1ou	39	35	tumour	tumour	NN
cord-344835-iivry1ou	39	36	necrosis	necrosis	NN
cord-344835-iivry1ou	39	37	factor	factor	NN
cord-344835-iivry1ou	39	38	-	-	HYPH
cord-344835-iivry1ou	39	39	alpha	alpha	NN
cord-344835-iivry1ou	39	40	(	(	-LRB-
cord-344835-iivry1ou	39	41	TNFalpha	TNFalpha	NNS
cord-344835-iivry1ou	39	42	)	)	-RRB-
cord-344835-iivry1ou	39	43	levels	level	NNS
cord-344835-iivry1ou	39	44	may	may	MD
cord-344835-iivry1ou	39	45	be	be	VB
cord-344835-iivry1ou	39	46	related	relate	VBN
cord-344835-iivry1ou	39	47	to	to	IN
cord-344835-iivry1ou	39	48	bronchial	bronchial	JJ
cord-344835-iivry1ou	39	49	colonization	colonization	NN
cord-344835-iivry1ou	39	50	[	[	-LRB-
cord-344835-iivry1ou	39	51	18	18	CD
cord-344835-iivry1ou	39	52	]	]	-RRB-
cord-344835-iivry1ou	39	53	.	.	.
cord-344835-iivry1ou	40	1	Increased	increase	VBN
cord-344835-iivry1ou	40	2	TNF	TNF	NNP
cord-344835-iivry1ou	40	3	-	-	HYPH
cord-344835-iivry1ou	40	4	alpha	alpha	NN
cord-344835-iivry1ou	40	5	,	,	,
cord-344835-iivry1ou	40	6	as	as	RB
cord-344835-iivry1ou	40	7	well	well	RB
cord-344835-iivry1ou	40	8	as	as	IN
cord-344835-iivry1ou	40	9	myeloperoxidase	myeloperoxidase	NNP
cord-344835-iivry1ou	40	10	(	(	-LRB-
cord-344835-iivry1ou	40	11	MPO	MPO	NNP
cord-344835-iivry1ou	40	12	)	)	-RRB-
cord-344835-iivry1ou	40	13	and	and	CC
cord-344835-iivry1ou	40	14	interleukin-8	interleukin-8	NNP
cord-344835-iivry1ou	41	1	(	(	-LRB-
cord-344835-iivry1ou	41	2	IL-8	il-8	NN
cord-344835-iivry1ou	41	3	)	)	-RRB-
cord-344835-iivry1ou	41	4	levels	level	NNS
cord-344835-iivry1ou	41	5	have	have	VBP
cord-344835-iivry1ou	41	6	been	be	VBN
cord-344835-iivry1ou	41	7	specifically	specifically	RB
cord-344835-iivry1ou	41	8	related	relate	VBN
cord-344835-iivry1ou	41	9	with	with	IN
cord-344835-iivry1ou	41	10	H.	H.	NNP
cord-344835-iivry1ou	41	11	Influenzae	Influenzae	NNP
cord-344835-iivry1ou	41	12	infection	infection	NN
cord-344835-iivry1ou	41	13	,	,	,
cord-344835-iivry1ou	41	14	as	as	IN
cord-344835-iivry1ou	41	15	shown	show	VBN
cord-344835-iivry1ou	41	16	by	by	IN
cord-344835-iivry1ou	41	17	Bresser	Bresser	NNP
cord-344835-iivry1ou	41	18	et	et	NNP
cord-344835-iivry1ou	41	19	al	al	NNP
cord-344835-iivry1ou	41	20	[	[	-LRB-
cord-344835-iivry1ou	41	21	19	19	CD
cord-344835-iivry1ou	41	22	]	]	-RRB-
cord-344835-iivry1ou	41	23	.	.	.
cord-344835-iivry1ou	42	1	However	however	RB
cord-344835-iivry1ou	42	2	,	,	,
cord-344835-iivry1ou	42	3	in	in	IN
cord-344835-iivry1ou	42	4	that	that	DT
cord-344835-iivry1ou	42	5	study	study	NN
cord-344835-iivry1ou	42	6	all	all	DT
cord-344835-iivry1ou	42	7	mediators	mediator	NNS
cord-344835-iivry1ou	42	8	were	be	VBD
cord-344835-iivry1ou	42	9	measured	measure	VBN
cord-344835-iivry1ou	42	10	in	in	IN
cord-344835-iivry1ou	42	11	frozen	frozen	JJ
cord-344835-iivry1ou	42	12	sputum	sputum	NN
cord-344835-iivry1ou	42	13	and	and	CC
cord-344835-iivry1ou	42	14	MPO	MPO	NNP
cord-344835-iivry1ou	42	15	and	and	CC
cord-344835-iivry1ou	42	16	IL-8	IL-8	NNP
cord-344835-iivry1ou	42	17	levels	level	NNS
cord-344835-iivry1ou	42	18	were	be	VBD
cord-344835-iivry1ou	42	19	only	only	RB
cord-344835-iivry1ou	42	20	retrospectively	retrospectively	RB
cord-344835-iivry1ou	42	21	compared	compare	VBN
cord-344835-iivry1ou	42	22	to	to	IN
cord-344835-iivry1ou	42	23	non	non	JJ
cord-344835-iivry1ou	42	24	-	-	JJ
cord-344835-iivry1ou	42	25	infected	infected	JJ
cord-344835-iivry1ou	42	26	patients	patient	NNS
cord-344835-iivry1ou	42	27	.	.	.
cord-344835-iivry1ou	43	1	In	in	IN
cord-344835-iivry1ou	43	2	fresh	fresh	JJ
cord-344835-iivry1ou	43	3	sputum	sputum	NN
cord-344835-iivry1ou	43	4	samples	sample	NNS
cord-344835-iivry1ou	43	5	from	from	IN
cord-344835-iivry1ou	43	6	COPD	COPD	NNP
cord-344835-iivry1ou	43	7	patients	patient	NNS
cord-344835-iivry1ou	43	8	R.	R.	NNP
cord-344835-iivry1ou	43	9	Stockley	Stockley	NNP
cord-344835-iivry1ou	43	10	and	and	CC
cord-344835-iivry1ou	43	11	his	-PRON-	PRP$
cord-344835-iivry1ou	43	12	group	group	NN
cord-344835-iivry1ou	43	13	demonstrated	demonstrate	VBD
cord-344835-iivry1ou	43	14	that	that	IN
cord-344835-iivry1ou	43	15	MPO	MPO	NNP
cord-344835-iivry1ou	43	16	,	,	,
cord-344835-iivry1ou	43	17	neutrophil	neutrophil	NN
cord-344835-iivry1ou	43	18	elastase	elastase	NN
cord-344835-iivry1ou	43	19	(	(	-LRB-
cord-344835-iivry1ou	43	20	NE	NE	NNP
cord-344835-iivry1ou	43	21	)	)	-RRB-
cord-344835-iivry1ou	43	22	activity	activity	NN
cord-344835-iivry1ou	43	23	,	,	,
cord-344835-iivry1ou	43	24	IL-8	IL-8	NNP
cord-344835-iivry1ou	43	25	and	and	CC
cord-344835-iivry1ou	43	26	LTB4	LTB4	NNP
cord-344835-iivry1ou	43	27	levels	level	NNS
cord-344835-iivry1ou	43	28	are	be	VBP
cord-344835-iivry1ou	43	29	positively	positively	RB
cord-344835-iivry1ou	43	30	related	relate	VBN
cord-344835-iivry1ou	43	31	to	to	IN
cord-344835-iivry1ou	43	32	sputum	sputum	JJ
cord-344835-iivry1ou	43	33	bacterial	bacterial	JJ
cord-344835-iivry1ou	43	34	load	load	NN
cord-344835-iivry1ou	43	35	[	[	-LRB-
cord-344835-iivry1ou	43	36	20	20	CD
cord-344835-iivry1ou	43	37	]	]	-RRB-
cord-344835-iivry1ou	43	38	.	.	.
cord-344835-iivry1ou	44	1	Moreover	moreover	RB
cord-344835-iivry1ou	44	2	,	,	,
cord-344835-iivry1ou	44	3	the	the	DT
cord-344835-iivry1ou	44	4	type	type	NN
cord-344835-iivry1ou	44	5	of	of	IN
cord-344835-iivry1ou	44	6	organism	organism	NN
cord-344835-iivry1ou	44	7	affected	affect	VBD
cord-344835-iivry1ou	44	8	sputum	sputum	NN
cord-344835-iivry1ou	44	9	MPO	MPO	NNP
cord-344835-iivry1ou	44	10	levels	level	NNS
cord-344835-iivry1ou	44	11	and	and	CC
cord-344835-iivry1ou	44	12	NE	NE	NNP
cord-344835-iivry1ou	44	13	activity	activity	NN
cord-344835-iivry1ou	44	14	;	;	:
cord-344835-iivry1ou	44	15	MPO	MPO	NNP
cord-344835-iivry1ou	44	16	levels	level	NNS
cord-344835-iivry1ou	44	17	were	be	VBD
cord-344835-iivry1ou	44	18	relatively	relatively	RB
cord-344835-iivry1ou	44	19	increased	increase	VBN
cord-344835-iivry1ou	44	20	in	in	IN
cord-344835-iivry1ou	44	21	the	the	DT
cord-344835-iivry1ou	44	22	presence	presence	NN
cord-344835-iivry1ou	44	23	of	of	IN
cord-344835-iivry1ou	44	24	Ps	Ps	NNP
cord-344835-iivry1ou	44	25	.	.	.
cord-344835-iivry1ou	45	1	Aeruginosa	aeruginosa	NN
cord-344835-iivry1ou	45	2	compared	compare	VBN
cord-344835-iivry1ou	45	3	to	to	IN
cord-344835-iivry1ou	45	4	H.	H.	NNP
cord-344835-iivry1ou	45	5	Influenzae	Influenzae	NNP
cord-344835-iivry1ou	45	6	and	and	CC
cord-344835-iivry1ou	45	7	to	to	IN
cord-344835-iivry1ou	45	8	M.	M.	NNP
cord-344835-iivry1ou	45	9	Catarrhalis	Catarrhalis	NNP
cord-344835-iivry1ou	45	10	.	.	.
cord-344835-iivry1ou	46	1	There	there	EX
cord-344835-iivry1ou	46	2	have	have	VBP
cord-344835-iivry1ou	46	3	been	be	VBN
cord-344835-iivry1ou	46	4	also	also	RB
cord-344835-iivry1ou	46	5	reports	report	NNS
cord-344835-iivry1ou	46	6	for	for	IN
cord-344835-iivry1ou	46	7	decreased	decrease	VBN
cord-344835-iivry1ou	46	8	secretory	secretory	JJ
cord-344835-iivry1ou	46	9	leukocyte	leukocyte	NN
cord-344835-iivry1ou	46	10	protease	protease	NN
cord-344835-iivry1ou	46	11	inhibitor	inhibitor	NN
cord-344835-iivry1ou	46	12	(	(	-LRB-
cord-344835-iivry1ou	46	13	SLPI	SLPI	NNP
cord-344835-iivry1ou	46	14	)	)	-RRB-
cord-344835-iivry1ou	46	15	in	in	IN
cord-344835-iivry1ou	46	16	sputum	sputum	NN
cord-344835-iivry1ou	46	17	samples	sample	NNS
cord-344835-iivry1ou	46	18	from	from	IN
cord-344835-iivry1ou	46	19	COPD	COPD	NNP
cord-344835-iivry1ou	46	20	patients	patient	NNS
cord-344835-iivry1ou	46	21	colonised	colonise	VBN
cord-344835-iivry1ou	46	22	with	with	IN
cord-344835-iivry1ou	46	23	bacteria	bacteria	NNS
cord-344835-iivry1ou	46	24	[	[	-LRB-
cord-344835-iivry1ou	46	25	20	20	CD
cord-344835-iivry1ou	46	26	,	,	,
cord-344835-iivry1ou	46	27	21	21	CD
cord-344835-iivry1ou	46	28	]	]	-RRB-
cord-344835-iivry1ou	46	29	.	.	.
cord-344835-iivry1ou	47	1	Upper	upper	JJ
cord-344835-iivry1ou	47	2	airways	airway	NNS
cord-344835-iivry1ou	47	3	inflammation	inflammation	NN
cord-344835-iivry1ou	47	4	in	in	IN
cord-344835-iivry1ou	47	5	COPD	COPD	NNP
cord-344835-iivry1ou	47	6	is	be	VBZ
cord-344835-iivry1ou	47	7	also	also	RB
cord-344835-iivry1ou	47	8	increased	increase	VBN
cord-344835-iivry1ou	47	9	when	when	WRB
cord-344835-iivry1ou	47	10	there	there	EX
cord-344835-iivry1ou	47	11	is	be	VBZ
cord-344835-iivry1ou	47	12	bacterial	bacterial	JJ
cord-344835-iivry1ou	47	13	colonization	colonization	NN
cord-344835-iivry1ou	47	14	[	[	-LRB-
cord-344835-iivry1ou	47	15	22	22	CD
cord-344835-iivry1ou	47	16	]	]	-RRB-
cord-344835-iivry1ou	47	17	.	.	.
cord-344835-iivry1ou	48	1	All	all	PDT
cord-344835-iivry1ou	48	2	these	these	DT
cord-344835-iivry1ou	48	3	results	result	NNS
cord-344835-iivry1ou	48	4	taken	take	VBN
cord-344835-iivry1ou	48	5	together	together	RB
cord-344835-iivry1ou	48	6	suggest	suggest	VBP
cord-344835-iivry1ou	48	7	that	that	IN
cord-344835-iivry1ou	48	8	bacteria	bacteria	NNS
cord-344835-iivry1ou	48	9	are	be	VBP
cord-344835-iivry1ou	48	10	[	[	-LRB-
cord-344835-iivry1ou	48	11	24	24	CD
cord-344835-iivry1ou	48	12	]	]	-RRB-
cord-344835-iivry1ou	48	13	.	.	.
cord-344835-iivry1ou	49	1	This	this	DT
cord-344835-iivry1ou	49	2	discrepancy	discrepancy	NN
cord-344835-iivry1ou	49	3	may	may	MD
cord-344835-iivry1ou	49	4	be	be	VB
cord-344835-iivry1ou	49	5	due	due	JJ
cord-344835-iivry1ou	49	6	to	to	IN
cord-344835-iivry1ou	49	7	differences	difference	NNS
cord-344835-iivry1ou	49	8	in	in	IN
cord-344835-iivry1ou	49	9	sputum	sputum	NN
cord-344835-iivry1ou	49	10	induction	induction	NN
cord-344835-iivry1ou	49	11	time	time	NN
cord-344835-iivry1ou	49	12	or	or	CC
cord-344835-iivry1ou	49	13	in	in	IN
cord-344835-iivry1ou	49	14	sputum	sputum	NN
cord-344835-iivry1ou	49	15	processing	processing	NN
cord-344835-iivry1ou	49	16	or	or	CC
cord-344835-iivry1ou	49	17	in	in	IN
cord-344835-iivry1ou	49	18	the	the	DT
cord-344835-iivry1ou	49	19	assays	assay	NNS
cord-344835-iivry1ou	49	20	used	use	VBN
cord-344835-iivry1ou	49	21	for	for	IN
cord-344835-iivry1ou	49	22	the	the	DT
cord-344835-iivry1ou	49	23	detection	detection	NN
cord-344835-iivry1ou	49	24	of	of	IN
cord-344835-iivry1ou	49	25	fluid	fluid	JJ
cord-344835-iivry1ou	49	26	-	-	HYPH
cord-344835-iivry1ou	49	27	phase	phase	NN
cord-344835-iivry1ou	49	28	mediators	mediator	NNS
cord-344835-iivry1ou	49	29	.	.	.
cord-344835-iivry1ou	50	1	Another	another	DT
cord-344835-iivry1ou	50	2	intriguing	intriguing	JJ
cord-344835-iivry1ou	50	3	hypothesis	hypothesis	NN
cord-344835-iivry1ou	50	4	is	be	VBZ
cord-344835-iivry1ou	50	5	that	that	IN
cord-344835-iivry1ou	50	6	different	different	JJ
cord-344835-iivry1ou	50	7	strains	strain	NNS
cord-344835-iivry1ou	50	8	of	of	IN
cord-344835-iivry1ou	50	9	the	the	DT
cord-344835-iivry1ou	50	10	same	same	JJ
cord-344835-iivry1ou	50	11	pathogens	pathogen	NNS
cord-344835-iivry1ou	50	12	may	may	MD
cord-344835-iivry1ou	50	13	induce	induce	VB
cord-344835-iivry1ou	50	14	different	different	JJ
cord-344835-iivry1ou	50	15	levels	level	NNS
cord-344835-iivry1ou	50	16	of	of	IN
cord-344835-iivry1ou	50	17	inflammation	inflammation	NN
cord-344835-iivry1ou	50	18	and	and	CC
cord-344835-iivry1ou	50	19	subjects	subject	NNS
cord-344835-iivry1ou	50	20	taking	take	VBG
cord-344835-iivry1ou	50	21	part	part	NN
cord-344835-iivry1ou	50	22	in	in	IN
cord-344835-iivry1ou	50	23	different	different	JJ
cord-344835-iivry1ou	50	24	studies	study	NNS
cord-344835-iivry1ou	50	25	might	may	MD
cord-344835-iivry1ou	50	26	have	have	VB
cord-344835-iivry1ou	50	27	been	be	VBN
cord-344835-iivry1ou	50	28	infected	infect	VBN
cord-344835-iivry1ou	50	29	by	by	IN
cord-344835-iivry1ou	50	30	different	different	JJ
cord-344835-iivry1ou	50	31	strains	strain	NNS
cord-344835-iivry1ou	50	32	of	of	IN
cord-344835-iivry1ou	50	33	H.	H.	NNP
cord-344835-iivry1ou	50	34	Influenzae	Influenzae	NNP
cord-344835-iivry1ou	50	35	.	.	.
cord-344835-iivry1ou	51	1	It	-PRON-	PRP
cord-344835-iivry1ou	51	2	was	be	VBD
cord-344835-iivry1ou	51	3	recently	recently	RB
cord-344835-iivry1ou	51	4	shown	show	VBN
cord-344835-iivry1ou	51	5	that	that	IN
cord-344835-iivry1ou	51	6	H.	H.	NNP
cord-344835-iivry1ou	51	7	Influenzae	Influenzae	NNP
cord-344835-iivry1ou	51	8	strains	strain	VBZ
cord-344835-iivry1ou	51	9	isolated	isolate	VBN
cord-344835-iivry1ou	51	10	from	from	IN
cord-344835-iivry1ou	51	11	COPD	COPD	NNP
cord-344835-iivry1ou	51	12	patients	patient	NNS
cord-344835-iivry1ou	51	13	during	during	IN
cord-344835-iivry1ou	51	14	exacerbation	exacerbation	NN
cord-344835-iivry1ou	51	15	induce	induce	VBP
cord-344835-iivry1ou	51	16	more	more	JJR
cord-344835-iivry1ou	51	17	inflammation	inflammation	NN
cord-344835-iivry1ou	51	18	than	than	IN
cord-344835-iivry1ou	51	19	strains	strain	NNS
cord-344835-iivry1ou	51	20	of	of	IN
cord-344835-iivry1ou	51	21	the	the	DT
cord-344835-iivry1ou	51	22	same	same	JJ
cord-344835-iivry1ou	51	23	pathogen	pathogen	NN
cord-344835-iivry1ou	51	24	isolated	isolate	VBN
cord-344835-iivry1ou	51	25	from	from	IN
cord-344835-iivry1ou	51	26	colonizers	colonizer	NNS
cord-344835-iivry1ou	51	27	[	[	-LRB-
cord-344835-iivry1ou	51	28	16	16	CD
cord-344835-iivry1ou	51	29	]	]	-RRB-
cord-344835-iivry1ou	51	30	.	.	.
cord-344835-iivry1ou	52	1	The	the	DT
cord-344835-iivry1ou	52	2	close	close	JJ
cord-344835-iivry1ou	52	3	association	association	NN
cord-344835-iivry1ou	52	4	between	between	IN
cord-344835-iivry1ou	52	5	airway	airway	NNP
cord-344835-iivry1ou	52	6	infections	infection	NNS
cord-344835-iivry1ou	52	7	and	and	CC
cord-344835-iivry1ou	52	8	increased	increase	VBN
cord-344835-iivry1ou	52	9	inflammation	inflammation	NN
cord-344835-iivry1ou	52	10	during	during	IN
cord-344835-iivry1ou	52	11	COPD	COPD	NNP
cord-344835-iivry1ou	52	12	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	52	13	has	have	VBZ
cord-344835-iivry1ou	52	14	been	be	VBN
cord-344835-iivry1ou	52	15	further	further	RB
cord-344835-iivry1ou	52	16	confirmed	confirm	VBN
cord-344835-iivry1ou	52	17	by	by	IN
cord-344835-iivry1ou	52	18	a	a	DT
cord-344835-iivry1ou	52	19	report	report	NN
cord-344835-iivry1ou	52	20	of	of	IN
cord-344835-iivry1ou	52	21	increased	increase	VBN
cord-344835-iivry1ou	52	22	systemic	systemic	JJ
cord-344835-iivry1ou	52	23	inflammation	inflammation	NN
cord-344835-iivry1ou	52	24	in	in	IN
cord-344835-iivry1ou	52	25	infected	infected	JJ
cord-344835-iivry1ou	52	26	patients	patient	NNS
cord-344835-iivry1ou	52	27	during	during	IN
cord-344835-iivry1ou	52	28	exacerbation	exacerbation	NN
cord-344835-iivry1ou	52	29	[	[	-LRB-
cord-344835-iivry1ou	52	30	25	25	CD
cord-344835-iivry1ou	52	31	]	]	-RRB-
cord-344835-iivry1ou	52	32	.	.	.
cord-344835-iivry1ou	53	1	Consistent	consistent	JJ
cord-344835-iivry1ou	53	2	with	with	IN
cord-344835-iivry1ou	53	3	these	these	DT
cord-344835-iivry1ou	53	4	observations	observation	NNS
cord-344835-iivry1ou	53	5	,	,	,
cord-344835-iivry1ou	53	6	airway	airway	NN
cord-344835-iivry1ou	53	7	inflammation	inflammation	NN
cord-344835-iivry1ou	53	8	can	can	MD
cord-344835-iivry1ou	53	9	be	be	VB
cord-344835-iivry1ou	53	10	decreased	decrease	VBN
cord-344835-iivry1ou	53	11	with	with	IN
cord-344835-iivry1ou	53	12	treatment	treatment	NN
cord-344835-iivry1ou	53	13	of	of	IN
cord-344835-iivry1ou	53	14	the	the	DT
cord-344835-iivry1ou	53	15	infection	infection	NN
cord-344835-iivry1ou	53	16	.	.	.
cord-344835-iivry1ou	54	1	Early	early	JJ
cord-344835-iivry1ou	54	2	evidence	evidence	NN
cord-344835-iivry1ou	54	3	came	come	VBD
cord-344835-iivry1ou	54	4	from	from	IN
cord-344835-iivry1ou	54	5	a	a	DT
cord-344835-iivry1ou	54	6	relatively	relatively	RB
cord-344835-iivry1ou	54	7	small	small	JJ
cord-344835-iivry1ou	54	8	study	study	NN
cord-344835-iivry1ou	54	9	,	,	,
cord-344835-iivry1ou	54	10	which	which	WDT
cord-344835-iivry1ou	54	11	showed	show	VBD
cord-344835-iivry1ou	54	12	that	that	IN
cord-344835-iivry1ou	54	13	neutrophilic	neutrophilic	NNP
cord-344835-iivry1ou	54	14	mediators	mediator	NNS
cord-344835-iivry1ou	54	15	'	'	POS
cord-344835-iivry1ou	54	16	levels	level	NNS
cord-344835-iivry1ou	54	17	may	may	MD
cord-344835-iivry1ou	54	18	decrease	decrease	VB
cord-344835-iivry1ou	54	19	after	after	IN
cord-344835-iivry1ou	54	20	treatment	treatment	NN
cord-344835-iivry1ou	54	21	of	of	IN
cord-344835-iivry1ou	54	22	bacterial	bacterial	JJ
cord-344835-iivry1ou	54	23	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	54	24	[	[	-LRB-
cord-344835-iivry1ou	54	25	26	26	CD
cord-344835-iivry1ou	54	26	]	]	-RRB-
cord-344835-iivry1ou	54	27	.	.	.
cord-344835-iivry1ou	55	1	Gompertz	Gompertz	NNP
cord-344835-iivry1ou	55	2	et	et	NNP
cord-344835-iivry1ou	55	3	al	al	NNP
cord-344835-iivry1ou	55	4	confirmed	confirm	VBD
cord-344835-iivry1ou	55	5	that	that	IN
cord-344835-iivry1ou	55	6	there	there	EX
cord-344835-iivry1ou	55	7	are	be	VBP
cord-344835-iivry1ou	55	8	significant	significant	JJ
cord-344835-iivry1ou	55	9	decreases	decrease	NNS
cord-344835-iivry1ou	55	10	in	in	IN
cord-344835-iivry1ou	55	11	neutrophilic	neutrophilic	JJ
cord-344835-iivry1ou	55	12	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	55	13	mediators	mediator	NNS
cord-344835-iivry1ou	55	14	after	after	IN
cord-344835-iivry1ou	55	15	treatment	treatment	NN
cord-344835-iivry1ou	55	16	of	of	IN
cord-344835-iivry1ou	55	17	purulent	purulent	JJ
cord-344835-iivry1ou	55	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	55	19	[	[	-LRB-
cord-344835-iivry1ou	55	20	27	27	CD
cord-344835-iivry1ou	55	21	]	]	-RRB-
cord-344835-iivry1ou	55	22	.	.	.
cord-344835-iivry1ou	56	1	Most	most	RBS
cord-344835-iivry1ou	56	2	importantly	importantly	RB
cord-344835-iivry1ou	56	3	,	,	,
cord-344835-iivry1ou	56	4	White	White	NNP
cord-344835-iivry1ou	56	5	et	et	NNP
cord-344835-iivry1ou	56	6	al	al	NNP
cord-344835-iivry1ou	56	7	studied	study	VBD
cord-344835-iivry1ou	56	8	patients	patient	NNS
cord-344835-iivry1ou	56	9	with	with	IN
cord-344835-iivry1ou	56	10	bacterial	bacterial	JJ
cord-344835-iivry1ou	56	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	56	12	and	and	CC
cord-344835-iivry1ou	56	13	demonstrated	demonstrate	VBD
cord-344835-iivry1ou	56	14	a	a	DT
cord-344835-iivry1ou	56	15	significant	significant	JJ
cord-344835-iivry1ou	56	16	fall	fall	NN
cord-344835-iivry1ou	56	17	in	in	IN
cord-344835-iivry1ou	56	18	sputum	sputum	NN
cord-344835-iivry1ou	56	19	leukotriene	leukotriene	NN
cord-344835-iivry1ou	56	20	B4	B4	NNP
cord-344835-iivry1ou	56	21	(	(	-LRB-
cord-344835-iivry1ou	56	22	LTB4	LTB4	NNP
cord-344835-iivry1ou	56	23	)	)	-RRB-
cord-344835-iivry1ou	56	24	levels	level	NNS
cord-344835-iivry1ou	56	25	and	and	CC
cord-344835-iivry1ou	56	26	an	an	DT
cord-344835-iivry1ou	56	27	increase	increase	NN
cord-344835-iivry1ou	56	28	in	in	IN
cord-344835-iivry1ou	56	29	SLPI	SLPI	NNP
cord-344835-iivry1ou	56	30	levels	level	NNS
cord-344835-iivry1ou	56	31	in	in	IN
cord-344835-iivry1ou	56	32	patients	patient	NNS
cord-344835-iivry1ou	56	33	in	in	IN
cord-344835-iivry1ou	56	34	whom	whom	WP
cord-344835-iivry1ou	56	35	bacteria	bacteria	NNS
cord-344835-iivry1ou	56	36	were	be	VBD
cord-344835-iivry1ou	56	37	eradicated	eradicate	VBN
cord-344835-iivry1ou	56	38	,	,	,
cord-344835-iivry1ou	56	39	but	but	CC
cord-344835-iivry1ou	56	40	not	not	RB
cord-344835-iivry1ou	56	41	in	in	IN
cord-344835-iivry1ou	56	42	those	those	DT
cord-344835-iivry1ou	56	43	in	in	IN
cord-344835-iivry1ou	56	44	whom	whom	WP
cord-344835-iivry1ou	56	45	bacteria	bacteria	NNS
cord-344835-iivry1ou	56	46	persisted	persist	VBD
cord-344835-iivry1ou	56	47	on	on	IN
cord-344835-iivry1ou	56	48	stable	stable	JJ
cord-344835-iivry1ou	56	49	state	state	NN
cord-344835-iivry1ou	56	50	[	[	-LRB-
cord-344835-iivry1ou	56	51	24	24	CD
cord-344835-iivry1ou	56	52	]	]	-RRB-
cord-344835-iivry1ou	56	53	.	.	.
cord-344835-iivry1ou	57	1	Moreover	moreover	RB
cord-344835-iivry1ou	57	2	,	,	,
cord-344835-iivry1ou	57	3	MPO	MPO	NNP
cord-344835-iivry1ou	57	4	and	and	CC
cord-344835-iivry1ou	57	5	LTB4	LTB4	NNP
cord-344835-iivry1ou	57	6	levels	level	NNS
cord-344835-iivry1ou	57	7	were	be	VBD
cord-344835-iivry1ou	57	8	significantly	significantly	RB
cord-344835-iivry1ou	57	9	lower	low	JJR
cord-344835-iivry1ou	57	10	and	and	CC
cord-344835-iivry1ou	57	11	SLPI	SLPI	NNP
cord-344835-iivry1ou	57	12	levels	level	NNS
cord-344835-iivry1ou	57	13	significantly	significantly	RB
cord-344835-iivry1ou	57	14	higher	higher	RBR
cord-344835-iivry1ou	57	15	in	in	IN
cord-344835-iivry1ou	57	16	patients	patient	NNS
cord-344835-iivry1ou	57	17	with	with	IN
cord-344835-iivry1ou	57	18	treated	treat	VBN
cord-344835-iivry1ou	57	19	compared	compare	VBN
cord-344835-iivry1ou	57	20	to	to	IN
cord-344835-iivry1ou	57	21	patients	patient	NNS
cord-344835-iivry1ou	57	22	with	with	IN
cord-344835-iivry1ou	57	23	untreated	untreated	JJ
cord-344835-iivry1ou	57	24	bacterial	bacterial	JJ
cord-344835-iivry1ou	57	25	infections	infection	NNS
cord-344835-iivry1ou	57	26	on	on	IN
cord-344835-iivry1ou	57	27	stable	stable	JJ
cord-344835-iivry1ou	57	28	state	state	NN
cord-344835-iivry1ou	57	29	.	.	.
cord-344835-iivry1ou	58	1	In	in	IN
cord-344835-iivry1ou	58	2	conclusion	conclusion	NN
cord-344835-iivry1ou	58	3	,	,	,
cord-344835-iivry1ou	58	4	three	three	CD
cord-344835-iivry1ou	58	5	major	major	JJ
cord-344835-iivry1ou	58	6	findings	finding	NNS
cord-344835-iivry1ou	58	7	support	support	VBP
cord-344835-iivry1ou	58	8	the	the	DT
cord-344835-iivry1ou	58	9	hypothesis	hypothesis	NN
cord-344835-iivry1ou	58	10	that	that	IN
cord-344835-iivry1ou	58	11	bacterial	bacterial	JJ
cord-344835-iivry1ou	58	12	infections	infection	NNS
cord-344835-iivry1ou	58	13	are	be	VBP
cord-344835-iivry1ou	58	14	actively	actively	RB
cord-344835-iivry1ou	58	15	implicated	implicate	VBN
cord-344835-iivry1ou	58	16	in	in	IN
cord-344835-iivry1ou	58	17	the	the	DT
cord-344835-iivry1ou	58	18	mechanisms	mechanism	NNS
cord-344835-iivry1ou	58	19	of	of	IN
cord-344835-iivry1ou	58	20	increased	increase	VBN
cord-344835-iivry1ou	58	21	airway	airway	NN
cord-344835-iivry1ou	58	22	inflammation	inflammation	NN
cord-344835-iivry1ou	58	23	during	during	IN
cord-344835-iivry1ou	58	24	COPD	COPD	NNP
cord-344835-iivry1ou	58	25	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	58	26	:	:	:
cord-344835-iivry1ou	58	27	1	1	LS
cord-344835-iivry1ou	58	28	)	)	-RRB-
cord-344835-iivry1ou	58	29	bacterial	bacterial	JJ
cord-344835-iivry1ou	58	30	infections	infection	NNS
cord-344835-iivry1ou	58	31	increase	increase	VBP
cord-344835-iivry1ou	58	32	airway	airway	NN
cord-344835-iivry1ou	58	33	inflammation	inflammation	NN
cord-344835-iivry1ou	58	34	in	in	IN
cord-344835-iivry1ou	58	35	colonized	colonize	VBN
cord-344835-iivry1ou	58	36	stable	stable	JJ
cord-344835-iivry1ou	58	37	COPD	COPD	NNP
cord-344835-iivry1ou	58	38	patients	patient	NNS
cord-344835-iivry1ou	58	39	2	2	CD
cord-344835-iivry1ou	58	40	)	)	-RRB-
cord-344835-iivry1ou	58	41	bacterial	bacterial	JJ
cord-344835-iivry1ou	58	42	-	-	HYPH
cord-344835-iivry1ou	58	43	positive	positive	JJ
cord-344835-iivry1ou	58	44	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	58	45	show	show	VBP
cord-344835-iivry1ou	58	46	increased	increase	VBN
cord-344835-iivry1ou	58	47	inflammation	inflammation	NN
cord-344835-iivry1ou	58	48	(	(	-LRB-
cord-344835-iivry1ou	58	49	particularly	particularly	RB
cord-344835-iivry1ou	58	50	of	of	IN
cord-344835-iivry1ou	58	51	neutrophilic	neutrophilic	NNP
cord-344835-iivry1ou	58	52	type	type	NN
cord-344835-iivry1ou	58	53	)	)	-RRB-
cord-344835-iivry1ou	58	54	compared	compare	VBN
cord-344835-iivry1ou	58	55	to	to	IN
cord-344835-iivry1ou	58	56	bacterial	bacterial	JJ
cord-344835-iivry1ou	58	57	-	-	HYPH
cord-344835-iivry1ou	58	58	negative	negative	JJ
cord-344835-iivry1ou	58	59	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	58	60	and	and	CC
cord-344835-iivry1ou	58	61	3	3	CD
cord-344835-iivry1ou	58	62	)	)	-RRB-
cord-344835-iivry1ou	58	63	eradication	eradication	NN
cord-344835-iivry1ou	58	64	of	of	IN
cord-344835-iivry1ou	58	65	bacteria	bacteria	NNS
cord-344835-iivry1ou	58	66	after	after	IN
cord-344835-iivry1ou	58	67	a	a	DT
cord-344835-iivry1ou	58	68	bacterial	bacterial	JJ
cord-344835-iivry1ou	58	69	exacerbation	exacerbation	NN
cord-344835-iivry1ou	58	70	is	be	VBZ
cord-344835-iivry1ou	58	71	accompanied	accompany	VBN
cord-344835-iivry1ou	58	72	by	by	IN
cord-344835-iivry1ou	58	73	a	a	DT
cord-344835-iivry1ou	58	74	significant	significant	JJ
cord-344835-iivry1ou	58	75	decrease	decrease	NN
cord-344835-iivry1ou	58	76	in	in	IN
cord-344835-iivry1ou	58	77	airway	airway	NN
cord-344835-iivry1ou	58	78	inflammation	inflammation	NN
cord-344835-iivry1ou	58	79	.	.	.
cord-344835-iivry1ou	59	1	A	a	DT
cord-344835-iivry1ou	59	2	summary	summary	NN
cord-344835-iivry1ou	59	3	of	of	IN
cord-344835-iivry1ou	59	4	these	these	DT
cord-344835-iivry1ou	59	5	findings	finding	NNS
cord-344835-iivry1ou	59	6	is	be	VBZ
cord-344835-iivry1ou	59	7	presented	present	VBN
cord-344835-iivry1ou	59	8	in	in	IN
cord-344835-iivry1ou	59	9	table	table	NN
cord-344835-iivry1ou	59	10	2	2	CD
cord-344835-iivry1ou	59	11	.	.	.
cord-344835-iivry1ou	60	1	1b	1b	CD
cord-344835-iivry1ou	60	2	Viral	viral	JJ
cord-344835-iivry1ou	60	3	infections	infection	NNS
cord-344835-iivry1ou	61	1	Respiratory	respiratory	JJ
cord-344835-iivry1ou	61	2	viruses	virus	NNS
cord-344835-iivry1ou	61	3	are	be	VBP
cord-344835-iivry1ou	61	4	important	important	JJ
cord-344835-iivry1ou	61	5	triggers	trigger	NNS
cord-344835-iivry1ou	61	6	of	of	IN
cord-344835-iivry1ou	61	7	COPD	COPD	NNP
cord-344835-iivry1ou	61	8	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	61	9	.	.	.
cord-344835-iivry1ou	62	1	Initial	initial	JJ
cord-344835-iivry1ou	62	2	studies	study	NNS
cord-344835-iivry1ou	62	3	using	use	VBG
cord-344835-iivry1ou	62	4	serology	serology	NN
cord-344835-iivry1ou	62	5	and	and	CC
cord-344835-iivry1ou	62	6	cell	cell	NN
cord-344835-iivry1ou	62	7	cultures	culture	NNS
cord-344835-iivry1ou	62	8	for	for	IN
cord-344835-iivry1ou	62	9	detecting	detect	VBG
cord-344835-iivry1ou	62	10	viral	viral	JJ
cord-344835-iivry1ou	62	11	infections	infection	NNS
cord-344835-iivry1ou	62	12	suggested	suggest	VBD
cord-344835-iivry1ou	62	13	that	that	IN
cord-344835-iivry1ou	62	14	30	30	CD
cord-344835-iivry1ou	62	15	%	%	NN
cord-344835-iivry1ou	62	16	of	of	IN
cord-344835-iivry1ou	62	17	COPD	COPD	NNP
cord-344835-iivry1ou	62	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	62	19	are	be	VBP
cord-344835-iivry1ou	62	20	related	relate	VBN
cord-344835-iivry1ou	62	21	to	to	IN
cord-344835-iivry1ou	62	22	viral	viral	JJ
cord-344835-iivry1ou	62	23	infections	infection	NNS
cord-344835-iivry1ou	62	24	[	[	-LRB-
cord-344835-iivry1ou	62	25	28	28	CD
cord-344835-iivry1ou	62	26	]	]	-RRB-
cord-344835-iivry1ou	62	27	[	[	-LRB-
cord-344835-iivry1ou	62	28	29	29	CD
cord-344835-iivry1ou	62	29	]	]	-RRB-
cord-344835-iivry1ou	62	30	[	[	-LRB-
cord-344835-iivry1ou	62	31	30	30	CD
cord-344835-iivry1ou	62	32	]	]	-RRB-
cord-344835-iivry1ou	62	33	.	.	.
cord-344835-iivry1ou	63	1	Later	later	JJ
cord-344835-iivry1ou	63	2	studies	study	NNS
cord-344835-iivry1ou	63	3	using	use	VBG
cord-344835-iivry1ou	63	4	the	the	DT
cord-344835-iivry1ou	63	5	more	more	RBR
cord-344835-iivry1ou	63	6	sensitive	sensitive	JJ
cord-344835-iivry1ou	63	7	method	method	NN
cord-344835-iivry1ou	63	8	of	of	IN
cord-344835-iivry1ou	63	9	reverse	reverse	JJ
cord-344835-iivry1ou	63	10	transcriptase	transcriptase	NN
cord-344835-iivry1ou	63	11	polymerase	polymerase	NN
cord-344835-iivry1ou	63	12	chain	chain	NN
cord-344835-iivry1ou	63	13	reaction	reaction	NN
cord-344835-iivry1ou	63	14	showed	show	VBD
cord-344835-iivry1ou	63	15	that	that	IN
cord-344835-iivry1ou	63	16	40%-50	40%-50	CD
cord-344835-iivry1ou	63	17	%	%	NN
cord-344835-iivry1ou	63	18	of	of	IN
cord-344835-iivry1ou	63	19	COPD	COPD	NNP
cord-344835-iivry1ou	63	20	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	63	21	may	may	MD
cord-344835-iivry1ou	63	22	be	be	VB
cord-344835-iivry1ou	63	23	secondary	secondary	JJ
cord-344835-iivry1ou	63	24	to	to	IN
cord-344835-iivry1ou	63	25	viral	viral	JJ
cord-344835-iivry1ou	63	26	infection	infection	NN
cord-344835-iivry1ou	63	27	[	[	-LRB-
cord-344835-iivry1ou	63	28	31	31	CD
cord-344835-iivry1ou	63	29	,	,	,
cord-344835-iivry1ou	63	30	32	32	CD
cord-344835-iivry1ou	63	31	]	]	-RRB-
cord-344835-iivry1ou	63	32	.	.	.
cord-344835-iivry1ou	64	1	Rhinoviruses	Rhinoviruses	NNP
cord-344835-iivry1ou	64	2	,	,	,
cord-344835-iivry1ou	64	3	picornaviruses	picornavirus	NNS
cord-344835-iivry1ou	64	4	,	,	,
cord-344835-iivry1ou	64	5	respiratory	respiratory	JJ
cord-344835-iivry1ou	64	6	syncytial	syncytial	JJ
cord-344835-iivry1ou	64	7	virus	virus	NN
cord-344835-iivry1ou	64	8	,	,	,
cord-344835-iivry1ou	64	9	influenza	influenza	NN
cord-344835-iivry1ou	64	10	A	a	NN
cord-344835-iivry1ou	64	11	and	and	CC
cord-344835-iivry1ou	64	12	B	b	NN
cord-344835-iivry1ou	64	13	and	and	CC
cord-344835-iivry1ou	64	14	coronaviruses	coronaviruse	NNS
cord-344835-iivry1ou	64	15	are	be	VBP
cord-344835-iivry1ou	64	16	more	more	RBR
cord-344835-iivry1ou	64	17	frequently	frequently	RB
cord-344835-iivry1ou	64	18	detected	detect	VBN
cord-344835-iivry1ou	64	19	[	[	-LRB-
cord-344835-iivry1ou	64	20	31	31	CD
cord-344835-iivry1ou	64	21	,	,	,
cord-344835-iivry1ou	64	22	32	32	CD
cord-344835-iivry1ou	64	23	]	]	-RRB-
cord-344835-iivry1ou	64	24	.	.	.
cord-344835-iivry1ou	65	1	Possible	possible	JJ
cord-344835-iivry1ou	65	2	mechanisms	mechanism	NNS
cord-344835-iivry1ou	65	3	of	of	IN
cord-344835-iivry1ou	65	4	viral	viral	RB
cord-344835-iivry1ou	65	5	-	-	HYPH
cord-344835-iivry1ou	65	6	induced	induce	VBN
cord-344835-iivry1ou	65	7	inflammation	inflammation	NN
cord-344835-iivry1ou	65	8	have	have	VBP
cord-344835-iivry1ou	65	9	been	be	VBN
cord-344835-iivry1ou	65	10	described	describe	VBN
cord-344835-iivry1ou	65	11	.	.	.
cord-344835-iivry1ou	66	1	The	the	DT
cord-344835-iivry1ou	66	2	airway	airway	NN
cord-344835-iivry1ou	66	3	epithelial	epithelial	JJ
cord-344835-iivry1ou	66	4	cell	cell	NN
cord-344835-iivry1ou	66	5	is	be	VBZ
cord-344835-iivry1ou	66	6	the	the	DT
cord-344835-iivry1ou	66	7	principal	principal	JJ
cord-344835-iivry1ou	66	8	host	host	NN
cord-344835-iivry1ou	66	9	cell	cell	NN
cord-344835-iivry1ou	66	10	for	for	IN
cord-344835-iivry1ou	66	11	most	most	JJS
cord-344835-iivry1ou	66	12	respiratory	respiratory	JJ
cord-344835-iivry1ou	66	13	viruses	virus	NNS
cord-344835-iivry1ou	66	14	[	[	-LRB-
cord-344835-iivry1ou	66	15	33	33	CD
cord-344835-iivry1ou	66	16	]	]	-RRB-
cord-344835-iivry1ou	66	17	.	.	.
cord-344835-iivry1ou	67	1	Viral	viral	JJ
cord-344835-iivry1ou	67	2	replication	replication	NN
cord-344835-iivry1ou	67	3	in	in	IN
cord-344835-iivry1ou	67	4	the	the	DT
cord-344835-iivry1ou	67	5	epithelial	epithelial	JJ
cord-344835-iivry1ou	67	6	cell	cell	NN
cord-344835-iivry1ou	67	7	triggers	trigger	VBZ
cord-344835-iivry1ou	67	8	intracellular	intracellular	JJ
cord-344835-iivry1ou	67	9	signalling	signal	VBG
cord-344835-iivry1ou	67	10	pathways	pathway	NNS
cord-344835-iivry1ou	67	11	,	,	,
cord-344835-iivry1ou	67	12	including	include	VBG
cord-344835-iivry1ou	67	13	activation	activation	NN
cord-344835-iivry1ou	67	14	of	of	IN
cord-344835-iivry1ou	67	15	NFκB	NFκB	NNP
cord-344835-iivry1ou	67	16	,	,	,
cord-344835-iivry1ou	67	17	which	which	WDT
cord-344835-iivry1ou	67	18	leads	lead	VBZ
cord-344835-iivry1ou	67	19	to	to	IN
cord-344835-iivry1ou	67	20	increases	increase	NNS
cord-344835-iivry1ou	67	21	in	in	IN
cord-344835-iivry1ou	67	22	the	the	DT
cord-344835-iivry1ou	67	23	secretion	secretion	NN
cord-344835-iivry1ou	67	24	of	of	IN
cord-344835-iivry1ou	67	25	multiple	multiple	JJ
cord-344835-iivry1ou	67	26	cytokines	cytokine	NNS
cord-344835-iivry1ou	67	27	and	and	CC
cord-344835-iivry1ou	67	28	recruitment	recruitment	NN
cord-344835-iivry1ou	67	29	of	of	IN
cord-344835-iivry1ou	67	30	multiple	multiple	JJ
cord-344835-iivry1ou	67	31	leukocytes	leukocyte	NNS
cord-344835-iivry1ou	67	32	to	to	IN
cord-344835-iivry1ou	67	33	the	the	DT
cord-344835-iivry1ou	67	34	airways	airways	NNPS
cord-344835-iivry1ou	67	35	[	[	-LRB-
cord-344835-iivry1ou	67	36	33	33	CD
cord-344835-iivry1ou	67	37	]	]	-RRB-
cord-344835-iivry1ou	67	38	.	.	.
cord-344835-iivry1ou	68	1	Antigen	antigen	NN
cord-344835-iivry1ou	68	2	presenting	present	VBG
cord-344835-iivry1ou	68	3	cells	cell	NNS
cord-344835-iivry1ou	68	4	are	be	VBP
cord-344835-iivry1ou	68	5	of	of	IN
cord-344835-iivry1ou	68	6	particular	particular	JJ
cord-344835-iivry1ou	68	7	importance	importance	NN
cord-344835-iivry1ou	68	8	,	,	,
cord-344835-iivry1ou	68	9	because	because	IN
cord-344835-iivry1ou	68	10	binding	bind	VBG
cord-344835-iivry1ou	68	11	of	of	IN
cord-344835-iivry1ou	68	12	viruses	virus	NNS
cord-344835-iivry1ou	68	13	to	to	IN
cord-344835-iivry1ou	68	14	these	these	DT
cord-344835-iivry1ou	68	15	cells	cell	NNS
cord-344835-iivry1ou	68	16	induces	induce	VBZ
cord-344835-iivry1ou	68	17	innate	innate	JJ
cord-344835-iivry1ou	68	18	and	and	CC
cord-344835-iivry1ou	68	19	adaptive	adaptive	JJ
cord-344835-iivry1ou	68	20	immune	immune	JJ
cord-344835-iivry1ou	68	21	responses	response	NNS
cord-344835-iivry1ou	68	22	and	and	CC
cord-344835-iivry1ou	68	23	T	T	NNP
cord-344835-iivry1ou	68	24	lymphocyte	lymphocyte	NN
cord-344835-iivry1ou	68	25	activation	activation	NN
cord-344835-iivry1ou	68	26	[	[	-LRB-
cord-344835-iivry1ou	68	27	34	34	CD
cord-344835-iivry1ou	68	28	]	]	-RRB-
cord-344835-iivry1ou	68	29	.	.	.
cord-344835-iivry1ou	69	1	There	there	EX
cord-344835-iivry1ou	69	2	is	be	VBZ
cord-344835-iivry1ou	69	3	convincing	convincing	JJ
cord-344835-iivry1ou	69	4	data	datum	NNS
cord-344835-iivry1ou	69	5	that	that	WDT
cord-344835-iivry1ou	69	6	viruses	virus	NNS
cord-344835-iivry1ou	69	7	induce	induce	VBP
cord-344835-iivry1ou	69	8	inflammation	inflammation	NN
cord-344835-iivry1ou	69	9	in	in	IN
cord-344835-iivry1ou	69	10	asthma	asthma	NN
cord-344835-iivry1ou	69	11	[	[	-LRB-
cord-344835-iivry1ou	69	12	35	35	CD
cord-344835-iivry1ou	69	13	]	]	-RRB-
cord-344835-iivry1ou	69	14	.	.	.
cord-344835-iivry1ou	70	1	In	in	IN
cord-344835-iivry1ou	70	2	animal	animal	NN
cord-344835-iivry1ou	70	3	models	model	NNS
cord-344835-iivry1ou	70	4	of	of	IN
cord-344835-iivry1ou	70	5	emphysema	emphysema	NN
cord-344835-iivry1ou	70	6	,	,	,
cord-344835-iivry1ou	70	7	latent	latent	JJ
cord-344835-iivry1ou	70	8	adenoviral	adenoviral	JJ
cord-344835-iivry1ou	70	9	infection	infection	NN
cord-344835-iivry1ou	70	10	amplifies	amplify	VBZ
cord-344835-iivry1ou	70	11	the	the	DT
cord-344835-iivry1ou	70	12	emphysematous	emphysematous	JJ
cord-344835-iivry1ou	70	13	destruction	destruction	NN
cord-344835-iivry1ou	70	14	and	and	CC
cord-344835-iivry1ou	70	15	increases	increase	VBZ
cord-344835-iivry1ou	70	16	the	the	DT
cord-344835-iivry1ou	70	17	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	70	18	response	response	NN
cord-344835-iivry1ou	70	19	[	[	-LRB-
cord-344835-iivry1ou	70	20	36	36	CD
cord-344835-iivry1ou	70	21	]	]	-RRB-
cord-344835-iivry1ou	70	22	.	.	.
cord-344835-iivry1ou	71	1	In	in	IN
cord-344835-iivry1ou	71	2	stable	stable	JJ
cord-344835-iivry1ou	71	3	COPD	COPD	NNP
cord-344835-iivry1ou	71	4	latent	latent	JJ
cord-344835-iivry1ou	71	5	adenoviral	adenoviral	JJ
cord-344835-iivry1ou	71	6	infection	infection	NN
cord-344835-iivry1ou	71	7	has	have	VBZ
cord-344835-iivry1ou	71	8	been	be	VBN
cord-344835-iivry1ou	71	9	associated	associate	VBN
cord-344835-iivry1ou	71	10	with	with	IN
cord-344835-iivry1ou	71	11	severe	severe	JJ
cord-344835-iivry1ou	71	12	emphysema	emphysema	NN
cord-344835-iivry1ou	71	13	and	and	CC
cord-344835-iivry1ou	71	14	increased	increase	VBN
cord-344835-iivry1ou	71	15	inflammation	inflammation	NN
cord-344835-iivry1ou	71	16	[	[	-LRB-
cord-344835-iivry1ou	71	17	37	37	CD
cord-344835-iivry1ou	71	18	]	]	-RRB-
cord-344835-iivry1ou	71	19	.	.	.
cord-344835-iivry1ou	72	1	The	the	DT
cord-344835-iivry1ou	72	2	group	group	NN
cord-344835-iivry1ou	72	3	of	of	IN
cord-344835-iivry1ou	72	4	J	J	NNP
cord-344835-iivry1ou	72	5	Wedzicha	Wedzicha	NNP
cord-344835-iivry1ou	72	6	showed	show	VBD
cord-344835-iivry1ou	72	7	that	that	IN
cord-344835-iivry1ou	72	8	viral	viral	JJ
cord-344835-iivry1ou	72	9	infections	infection	NNS
cord-344835-iivry1ou	72	10	might	may	MD
cord-344835-iivry1ou	72	11	be	be	VB
cord-344835-iivry1ou	72	12	implicated	implicate	VBN
cord-344835-iivry1ou	72	13	in	in	IN
cord-344835-iivry1ou	72	14	the	the	DT
cord-344835-iivry1ou	72	15	mechanisms	mechanism	NNS
cord-344835-iivry1ou	72	16	of	of	IN
cord-344835-iivry1ou	72	17	increased	increase	VBN
cord-344835-iivry1ou	72	18	airway	airway	NN
cord-344835-iivry1ou	72	19	and	and	CC
cord-344835-iivry1ou	72	20	possibly	possibly	RB
cord-344835-iivry1ou	72	21	systemic	systemic	JJ
cord-344835-iivry1ou	72	22	inflammation	inflammation	NN
cord-344835-iivry1ou	72	23	during	during	IN
cord-344835-iivry1ou	72	24	COPD	COPD	NNP
cord-344835-iivry1ou	72	25	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	72	26	.	.	.
cord-344835-iivry1ou	73	1	Plasma	Plasma	NNP
cord-344835-iivry1ou	73	2	IL-6	IL-6	NNP
cord-344835-iivry1ou	73	3	and	and	CC
cord-344835-iivry1ou	73	4	fibrinogen	fibrinogen	NN
cord-344835-iivry1ou	73	5	levels	level	NNS
cord-344835-iivry1ou	73	6	were	be	VBD
cord-344835-iivry1ou	73	7	higher	high	JJR
cord-344835-iivry1ou	73	8	during	during	IN
cord-344835-iivry1ou	73	9	viral	viral	JJ
cord-344835-iivry1ou	73	10	than	than	IN
cord-344835-iivry1ou	73	11	non	non	JJ
cord-344835-iivry1ou	73	12	-	-	JJ
cord-344835-iivry1ou	73	13	viral	viral	JJ
cord-344835-iivry1ou	73	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	73	15	,	,	,
cord-344835-iivry1ou	73	16	although	although	IN
cord-344835-iivry1ou	73	17	the	the	DT
cord-344835-iivry1ou	73	18	difference	difference	NN
cord-344835-iivry1ou	73	19	just	just	RB
cord-344835-iivry1ou	73	20	failed	fail	VBD
cord-344835-iivry1ou	73	21	to	to	TO
cord-344835-iivry1ou	73	22	reach	reach	VB
cord-344835-iivry1ou	73	23	statistical	statistical	JJ
cord-344835-iivry1ou	73	24	significance	significance	NN
cord-344835-iivry1ou	73	25	[	[	-LRB-
cord-344835-iivry1ou	73	26	31	31	CD
cord-344835-iivry1ou	73	27	]	]	-RRB-
cord-344835-iivry1ou	73	28	.	.	.
cord-344835-iivry1ou	74	1	However	however	RB
cord-344835-iivry1ou	74	2	,	,	,
cord-344835-iivry1ou	74	3	in	in	IN
cord-344835-iivry1ou	74	4	that	that	DT
cord-344835-iivry1ou	74	5	study	study	NN
cord-344835-iivry1ou	74	6	viruses	virus	NNS
cord-344835-iivry1ou	74	7	were	be	VBD
cord-344835-iivry1ou	74	8	detected	detect	VBN
cord-344835-iivry1ou	74	9	in	in	IN
cord-344835-iivry1ou	74	10	nasal	nasal	NN
cord-344835-iivry1ou	74	11	samples	sample	NNS
cord-344835-iivry1ou	74	12	and	and	CC
cord-344835-iivry1ou	74	13	it	-PRON-	PRP
cord-344835-iivry1ou	74	14	has	have	VBZ
cord-344835-iivry1ou	74	15	been	be	VBN
cord-344835-iivry1ou	74	16	shown	show	VBN
cord-344835-iivry1ou	74	17	that	that	IN
cord-344835-iivry1ou	74	18	in	in	IN
cord-344835-iivry1ou	74	19	COPD	COPD	NNP
cord-344835-iivry1ou	74	20	patients	patient	NNS
cord-344835-iivry1ou	74	21	respiratory	respiratory	JJ
cord-344835-iivry1ou	74	22	viruses	virus	NNS
cord-344835-iivry1ou	74	23	are	be	VBP
cord-344835-iivry1ou	74	24	detected	detect	VBN
cord-344835-iivry1ou	74	25	more	more	RBR
cord-344835-iivry1ou	74	26	frequently	frequently	RB
cord-344835-iivry1ou	74	27	in	in	IN
cord-344835-iivry1ou	74	28	induced	induce	VBN
cord-344835-iivry1ou	74	29	sputum	sputum	NN
cord-344835-iivry1ou	74	30	than	than	IN
cord-344835-iivry1ou	74	31	in	in	IN
cord-344835-iivry1ou	74	32	nasal	nasal	NN
cord-344835-iivry1ou	74	33	lavage	lavage	NN
cord-344835-iivry1ou	74	34	[	[	-LRB-
cord-344835-iivry1ou	74	35	32	32	CD
cord-344835-iivry1ou	74	36	,	,	,
cord-344835-iivry1ou	74	37	38	38	CD
cord-344835-iivry1ou	74	38	]	]	-RRB-
cord-344835-iivry1ou	74	39	.	.	.
cord-344835-iivry1ou	75	1	When	when	WRB
cord-344835-iivry1ou	75	2	rhinovirus	rhinovirus	NN
cord-344835-iivry1ou	75	3	infection	infection	NN
cord-344835-iivry1ou	75	4	was	be	VBD
cord-344835-iivry1ou	75	5	detected	detect	VBN
cord-344835-iivry1ou	75	6	in	in	IN
cord-344835-iivry1ou	75	7	induced	induce	VBN
cord-344835-iivry1ou	75	8	sputum	sputum	NN
cord-344835-iivry1ou	75	9	samples	sample	VBZ
cord-344835-iivry1ou	75	10	a	a	DT
cord-344835-iivry1ou	75	11	significant	significant	JJ
cord-344835-iivry1ou	75	12	correlation	correlation	NN
cord-344835-iivry1ou	75	13	was	be	VBD
cord-344835-iivry1ou	75	14	demonstrated	demonstrate	VBN
cord-344835-iivry1ou	75	15	between	between	IN
cord-344835-iivry1ou	75	16	rhinovirus	rhinovirus	NN
cord-344835-iivry1ou	75	17	infection	infection	NN
cord-344835-iivry1ou	75	18	and	and	CC
cord-344835-iivry1ou	75	19	increased	increase	VBN
cord-344835-iivry1ou	75	20	sputum	sputum	NN
cord-344835-iivry1ou	75	21	IL-6	IL-6	NNP
cord-344835-iivry1ou	75	22	levels	level	NNS
cord-344835-iivry1ou	75	23	on	on	IN
cord-344835-iivry1ou	75	24	COPD	COPD	NNP
cord-344835-iivry1ou	75	25	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	75	26	[	[	-LRB-
cord-344835-iivry1ou	75	27	38	38	CD
cord-344835-iivry1ou	75	28	]	]	-RRB-
cord-344835-iivry1ou	75	29	.	.	.
cord-344835-iivry1ou	76	1	Further	further	RB
cord-344835-iivry1ou	76	2	to	to	IN
cord-344835-iivry1ou	76	3	these	these	DT
cord-344835-iivry1ou	76	4	observations	observation	NNS
cord-344835-iivry1ou	76	5	,	,	,
cord-344835-iivry1ou	76	6	two	two	CD
cord-344835-iivry1ou	76	7	recent	recent	JJ
cord-344835-iivry1ou	76	8	studies	study	NNS
cord-344835-iivry1ou	76	9	showed	show	VBD
cord-344835-iivry1ou	76	10	that	that	IN
cord-344835-iivry1ou	76	11	viral	viral	JJ
cord-344835-iivry1ou	76	12	airway	airway	NN
cord-344835-iivry1ou	76	13	infections	infection	NNS
cord-344835-iivry1ou	76	14	during	during	IN
cord-344835-iivry1ou	76	15	COPD	COPD	NNP
cord-344835-iivry1ou	76	16	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	76	17	are	be	VBP
cord-344835-iivry1ou	76	18	related	relate	VBN
cord-344835-iivry1ou	76	19	to	to	IN
cord-344835-iivry1ou	76	20	airway	airway	NN
cord-344835-iivry1ou	76	21	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	76	22	[	[	-LRB-
cord-344835-iivry1ou	76	23	39	39	CD
cord-344835-iivry1ou	76	24	,	,	,
cord-344835-iivry1ou	76	25	40	40	CD
cord-344835-iivry1ou	76	26	]	]	-RRB-
cord-344835-iivry1ou	76	27	.	.	.
cord-344835-iivry1ou	77	1	This	this	DT
cord-344835-iivry1ou	77	2	new	new	JJ
cord-344835-iivry1ou	77	3	find	find	NN
cord-344835-iivry1ou	77	4	-	-	HYPH
cord-344835-iivry1ou	77	5	ing	ing	NN
cord-344835-iivry1ou	77	6	may	may	MD
cord-344835-iivry1ou	77	7	be	be	VB
cord-344835-iivry1ou	77	8	of	of	IN
cord-344835-iivry1ou	77	9	particular	particular	JJ
cord-344835-iivry1ou	77	10	clinical	clinical	JJ
cord-344835-iivry1ou	77	11	importance	importance	NN
cord-344835-iivry1ou	77	12	as	as	IN
cord-344835-iivry1ou	77	13	airway	airway	NN
cord-344835-iivry1ou	77	14	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	77	15	could	could	MD
cord-344835-iivry1ou	77	16	be	be	VB
cord-344835-iivry1ou	77	17	used	use	VBN
cord-344835-iivry1ou	77	18	as	as	IN
cord-344835-iivry1ou	77	19	an	an	DT
cord-344835-iivry1ou	77	20	indicator	indicator	NN
cord-344835-iivry1ou	77	21	of	of	IN
cord-344835-iivry1ou	77	22	viral	viral	JJ
cord-344835-iivry1ou	77	23	infection	infection	NN
cord-344835-iivry1ou	77	24	during	during	IN
cord-344835-iivry1ou	77	25	an	an	DT
cord-344835-iivry1ou	77	26	exacerbation	exacerbation	NN
cord-344835-iivry1ou	77	27	.	.	.
cord-344835-iivry1ou	78	1	The	the	DT
cord-344835-iivry1ou	78	2	important	important	JJ
cord-344835-iivry1ou	78	3	role	role	NN
cord-344835-iivry1ou	78	4	of	of	IN
cord-344835-iivry1ou	78	5	eosinophils	eosinophil	NNS
cord-344835-iivry1ou	78	6	in	in	IN
cord-344835-iivry1ou	78	7	the	the	DT
cord-344835-iivry1ou	78	8	pathogenesis	pathogenesis	NN
cord-344835-iivry1ou	78	9	of	of	IN
cord-344835-iivry1ou	78	10	COPD	COPD	NNP
cord-344835-iivry1ou	78	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	78	12	is	be	VBZ
cord-344835-iivry1ou	78	13	further	further	RB
cord-344835-iivry1ou	78	14	supported	support	VBN
cord-344835-iivry1ou	78	15	by	by	IN
cord-344835-iivry1ou	78	16	studies	study	NNS
cord-344835-iivry1ou	78	17	in	in	IN
cord-344835-iivry1ou	78	18	bronchial	bronchial	JJ
cord-344835-iivry1ou	78	19	biopsies	biopsy	NNS
cord-344835-iivry1ou	78	20	and	and	CC
cord-344835-iivry1ou	78	21	sputum	sputum	NN
cord-344835-iivry1ou	78	22	samples	sample	NNS
cord-344835-iivry1ou	78	23	,	,	,
cord-344835-iivry1ou	78	24	which	which	WDT
cord-344835-iivry1ou	78	25	show	show	VBP
cord-344835-iivry1ou	78	26	increased	increase	VBD
cord-344835-iivry1ou	78	27	eosinophil	eosinophil	JJ
cord-344835-iivry1ou	78	28	numbers	number	NNS
cord-344835-iivry1ou	78	29	and	and	CC
cord-344835-iivry1ou	78	30	eosinophil	eosinophil	JJ
cord-344835-iivry1ou	78	31	mediators	mediator	NNS
cord-344835-iivry1ou	78	32	in	in	IN
cord-344835-iivry1ou	78	33	COPD	COPD	NNP
cord-344835-iivry1ou	78	34	patients	patient	NNS
cord-344835-iivry1ou	78	35	during	during	IN
cord-344835-iivry1ou	78	36	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	78	37	[	[	-LRB-
cord-344835-iivry1ou	78	38	41	41	CD
cord-344835-iivry1ou	78	39	]	]	-RRB-
cord-344835-iivry1ou	78	40	[	[	-LRB-
cord-344835-iivry1ou	78	41	42	42	CD
cord-344835-iivry1ou	78	42	]	]	-RRB-
cord-344835-iivry1ou	78	43	[	[	-LRB-
cord-344835-iivry1ou	78	44	43	43	CD
cord-344835-iivry1ou	78	45	]	]	-RRB-
cord-344835-iivry1ou	78	46	[	[	-LRB-
cord-344835-iivry1ou	78	47	44	44	CD
cord-344835-iivry1ou	78	48	]	]	-RRB-
cord-344835-iivry1ou	78	49	[	[	-LRB-
cord-344835-iivry1ou	78	50	45	45	CD
cord-344835-iivry1ou	78	51	]	]	-RRB-
cord-344835-iivry1ou	78	52	[	[	-LRB-
cord-344835-iivry1ou	78	53	46	46	CD
cord-344835-iivry1ou	78	54	]	]	-RRB-
cord-344835-iivry1ou	78	55	.	.	.
cord-344835-iivry1ou	79	1	Eosinophils	Eosinophils	NNP
cord-344835-iivry1ou	79	2	may	may	MD
cord-344835-iivry1ou	79	3	be	be	VB
cord-344835-iivry1ou	79	4	actively	actively	RB
cord-344835-iivry1ou	79	5	involved	involve	VBN
cord-344835-iivry1ou	79	6	in	in	IN
cord-344835-iivry1ou	79	7	the	the	DT
cord-344835-iivry1ou	79	8	pathogenesis	pathogenesis	NN
cord-344835-iivry1ou	79	9	of	of	IN
cord-344835-iivry1ou	79	10	viral	viral	RB
cord-344835-iivry1ou	79	11	-	-	HYPH
cord-344835-iivry1ou	79	12	induced	induce	VBN
cord-344835-iivry1ou	79	13	COPD	COPD	NNP
cord-344835-iivry1ou	79	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	79	15	through	through	IN
cord-344835-iivry1ou	79	16	the	the	DT
cord-344835-iivry1ou	79	17	release	release	NN
cord-344835-iivry1ou	79	18	of	of	IN
cord-344835-iivry1ou	79	19	destructive	destructive	JJ
cord-344835-iivry1ou	79	20	enzymes	enzyme	NNS
cord-344835-iivry1ou	79	21	,	,	,
cord-344835-iivry1ou	79	22	reactive	reactive	JJ
cord-344835-iivry1ou	79	23	oxygen	oxygen	NN
cord-344835-iivry1ou	79	24	species	specie	NNS
cord-344835-iivry1ou	79	25	and	and	CC
cord-344835-iivry1ou	79	26	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	79	27	mediators	mediator	NNS
cord-344835-iivry1ou	79	28	.	.	.
cord-344835-iivry1ou	80	1	1c	1c	LS
cord-344835-iivry1ou	80	2	Atypical	atypical	JJ
cord-344835-iivry1ou	80	3	bacteria	bacteria	NNS
cord-344835-iivry1ou	80	4	Atypical	atypical	JJ
cord-344835-iivry1ou	80	5	pathogens	pathogen	NNS
cord-344835-iivry1ou	80	6	with	with	IN
cord-344835-iivry1ou	80	7	potential	potential	JJ
cord-344835-iivry1ou	80	8	importance	importance	NN
cord-344835-iivry1ou	80	9	in	in	IN
cord-344835-iivry1ou	80	10	acute	acute	JJ
cord-344835-iivry1ou	80	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	80	12	include	include	VBP
cord-344835-iivry1ou	80	13	M.	M.	NNP
cord-344835-iivry1ou	80	14	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	80	15	,	,	,
cord-344835-iivry1ou	80	16	C.	C.	NNP
cord-344835-iivry1ou	80	17	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	80	18	and	and	CC
cord-344835-iivry1ou	80	19	Legionella	Legionella	NNP
cord-344835-iivry1ou	80	20	spp	spp	NNS
cord-344835-iivry1ou	80	21	.	.	.
cord-344835-iivry1ou	81	1	Considerable	considerable	JJ
cord-344835-iivry1ou	81	2	confusion	confusion	NN
cord-344835-iivry1ou	81	3	exists	exist	VBZ
cord-344835-iivry1ou	81	4	in	in	IN
cord-344835-iivry1ou	81	5	the	the	DT
cord-344835-iivry1ou	81	6	literature	literature	NN
cord-344835-iivry1ou	81	7	regarding	regard	VBG
cord-344835-iivry1ou	81	8	the	the	DT
cord-344835-iivry1ou	81	9	significance	significance	NN
cord-344835-iivry1ou	81	10	of	of	IN
cord-344835-iivry1ou	81	11	these	these	DT
cord-344835-iivry1ou	81	12	potential	potential	JJ
cord-344835-iivry1ou	81	13	pathogens	pathogen	NNS
cord-344835-iivry1ou	81	14	in	in	IN
cord-344835-iivry1ou	81	15	acute	acute	JJ
cord-344835-iivry1ou	81	16	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	81	17	of	of	IN
cord-344835-iivry1ou	81	18	COPD	COPD	NNP
cord-344835-iivry1ou	81	19	[	[	-LRB-
cord-344835-iivry1ou	81	20	47	47	CD
cord-344835-iivry1ou	81	21	]	]	-RRB-
cord-344835-iivry1ou	81	22	.	.	.
cord-344835-iivry1ou	82	1	This	this	DT
cord-344835-iivry1ou	82	2	is	be	VBZ
cord-344835-iivry1ou	82	3	partly	partly	RB
cord-344835-iivry1ou	82	4	due	due	JJ
cord-344835-iivry1ou	82	5	to	to	IN
cord-344835-iivry1ou	82	6	differences	difference	NNS
cord-344835-iivry1ou	82	7	in	in	IN
cord-344835-iivry1ou	82	8	the	the	DT
cord-344835-iivry1ou	82	9	techniques	technique	NNS
cord-344835-iivry1ou	82	10	used	use	VBN
cord-344835-iivry1ou	82	11	to	to	TO
cord-344835-iivry1ou	82	12	detect	detect	VB
cord-344835-iivry1ou	82	13	the	the	DT
cord-344835-iivry1ou	82	14	presence	presence	NN
cord-344835-iivry1ou	82	15	of	of	IN
cord-344835-iivry1ou	82	16	atypical	atypical	JJ
cord-344835-iivry1ou	82	17	infections	infection	NNS
cord-344835-iivry1ou	82	18	.	.	.
cord-344835-iivry1ou	83	1	When	when	WRB
cord-344835-iivry1ou	83	2	a	a	DT
cord-344835-iivry1ou	83	3	fourfold	fourfold	JJ
cord-344835-iivry1ou	83	4	increase	increase	NN
cord-344835-iivry1ou	83	5	in	in	IN
cord-344835-iivry1ou	83	6	antibody	antibody	NN
cord-344835-iivry1ou	83	7	titter	titter	NN
cord-344835-iivry1ou	83	8	or	or	CC
cord-344835-iivry1ou	83	9	a	a	DT
cord-344835-iivry1ou	83	10	positive	positive	JJ
cord-344835-iivry1ou	83	11	culture	culture	NN
cord-344835-iivry1ou	83	12	or	or	CC
cord-344835-iivry1ou	83	13	RT	RT	NNP
cord-344835-iivry1ou	83	14	-	-	HYPH
cord-344835-iivry1ou	83	15	PCR	PCR	NNP
cord-344835-iivry1ou	83	16	is	be	VBZ
cord-344835-iivry1ou	83	17	used	use	VBN
cord-344835-iivry1ou	83	18	,	,	,
cord-344835-iivry1ou	83	19	M.	M.	NNP
cord-344835-iivry1ou	83	20	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	83	21	and	and	CC
cord-344835-iivry1ou	83	22	Legionella	Legionella	NNP
cord-344835-iivry1ou	83	23	are	be	VBP
cord-344835-iivry1ou	83	24	rare	rare	JJ
cord-344835-iivry1ou	83	25	and	and	CC
cord-344835-iivry1ou	83	26	C.	C.	NNP
cord-344835-iivry1ou	83	27	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	83	28	infection	infection	NN
cord-344835-iivry1ou	83	29	may	may	MD
cord-344835-iivry1ou	83	30	be	be	VB
cord-344835-iivry1ou	83	31	involved	involve	VBN
cord-344835-iivry1ou	83	32	in	in	IN
cord-344835-iivry1ou	83	33	up	up	IN
cord-344835-iivry1ou	83	34	to	to	TO
cord-344835-iivry1ou	83	35	9	9	CD
cord-344835-iivry1ou	83	36	%	%	NN
cord-344835-iivry1ou	83	37	of	of	IN
cord-344835-iivry1ou	83	38	COPD	COPD	NNP
cord-344835-iivry1ou	83	39	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	83	40	[	[	-LRB-
cord-344835-iivry1ou	83	41	30	30	CD
cord-344835-iivry1ou	83	42	,	,	,
cord-344835-iivry1ou	83	43	[	[	-LRB-
cord-344835-iivry1ou	83	44	48	48	CD
cord-344835-iivry1ou	83	45	]	]	-RRB-
cord-344835-iivry1ou	84	1	[	[	-LRB-
cord-344835-iivry1ou	84	2	49	49	CD
cord-344835-iivry1ou	84	3	]	]	-RRB-
cord-344835-iivry1ou	84	4	[	[	-LRB-
cord-344835-iivry1ou	84	5	50	50	CD
cord-344835-iivry1ou	84	6	]	]	-RRB-
cord-344835-iivry1ou	84	7	.	.	.
cord-344835-iivry1ou	85	1	Moreover	moreover	RB
cord-344835-iivry1ou	85	2	,	,	,
cord-344835-iivry1ou	85	3	chronic	chronic	JJ
cord-344835-iivry1ou	85	4	colonization	colonization	NN
cord-344835-iivry1ou	85	5	with	with	IN
cord-344835-iivry1ou	85	6	C.	C.	NNP
cord-344835-iivry1ou	85	7	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	85	8	may	may	MD
cord-344835-iivry1ou	85	9	be	be	VB
cord-344835-iivry1ou	85	10	associated	associate	VBN
cord-344835-iivry1ou	85	11	with	with	IN
cord-344835-iivry1ou	85	12	a	a	DT
cord-344835-iivry1ou	85	13	higher	high	JJR
cord-344835-iivry1ou	85	14	rate	rate	NN
cord-344835-iivry1ou	85	15	of	of	IN
cord-344835-iivry1ou	85	16	COPD	COPD	NNP
cord-344835-iivry1ou	85	17	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	85	18	[	[	-LRB-
cord-344835-iivry1ou	85	19	51	51	CD
cord-344835-iivry1ou	85	20	]	]	-RRB-
cord-344835-iivry1ou	85	21	.	.	.
cord-344835-iivry1ou	86	1	C.	C.	NNP
cord-344835-iivry1ou	86	2	Pneumonia	Pneumonia	NNP
cord-344835-iivry1ou	86	3	infection	infection	NN
cord-344835-iivry1ou	86	4	can	can	MD
cord-344835-iivry1ou	86	5	amplify	amplify	VB
cord-344835-iivry1ou	86	6	inflammation	inflammation	NN
cord-344835-iivry1ou	86	7	in	in	IN
cord-344835-iivry1ou	86	8	the	the	DT
cord-344835-iivry1ou	86	9	airways	airway	NNS
cord-344835-iivry1ou	86	10	of	of	IN
cord-344835-iivry1ou	86	11	COPD	COPD	NNP
cord-344835-iivry1ou	86	12	patients	patient	NNS
cord-344835-iivry1ou	86	13	by	by	IN
cord-344835-iivry1ou	86	14	stimulating	stimulate	VBG
cord-344835-iivry1ou	86	15	the	the	DT
cord-344835-iivry1ou	86	16	production	production	NN
cord-344835-iivry1ou	86	17	and	and	CC
cord-344835-iivry1ou	86	18	expression	expression	NN
cord-344835-iivry1ou	86	19	of	of	IN
cord-344835-iivry1ou	86	20	cytokines	cytokine	NNS
cord-344835-iivry1ou	86	21	,	,	,
cord-344835-iivry1ou	86	22	chemokines	chemokine	NNS
cord-344835-iivry1ou	86	23	and	and	CC
cord-344835-iivry1ou	86	24	adhesion	adhesion	NN
cord-344835-iivry1ou	86	25	molecules	molecule	NNS
cord-344835-iivry1ou	86	26	[	[	-LRB-
cord-344835-iivry1ou	86	27	52	52	CD
cord-344835-iivry1ou	86	28	]	]	-RRB-
cord-344835-iivry1ou	86	29	.	.	.
cord-344835-iivry1ou	87	1	However	however	RB
cord-344835-iivry1ou	87	2	,	,	,
cord-344835-iivry1ou	87	3	clear	clear	JJ
cord-344835-iivry1ou	87	4	evidence	evidence	NN
cord-344835-iivry1ou	87	5	showing	show	VBG
cord-344835-iivry1ou	87	6	a	a	DT
cord-344835-iivry1ou	87	7	direct	direct	JJ
cord-344835-iivry1ou	87	8	relationship	relationship	NN
cord-344835-iivry1ou	87	9	between	between	IN
cord-344835-iivry1ou	87	10	increased	increased	JJ
cord-344835-iivry1ou	87	11	inflammation	inflammation	NN
cord-344835-iivry1ou	87	12	and	and	CC
cord-344835-iivry1ou	87	13	C.	C.	NNP
cord-344835-iivry1ou	87	14	Pneumoniae	Pneumoniae	NNP
cord-344835-iivry1ou	87	15	infection	infection	NN
cord-344835-iivry1ou	87	16	during	during	IN
cord-344835-iivry1ou	87	17	COPD	COPD	NNP
cord-344835-iivry1ou	87	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	87	19	is	be	VBZ
cord-344835-iivry1ou	87	20	yet	yet	RB
cord-344835-iivry1ou	87	21	lacking	lack	VBG
cord-344835-iivry1ou	87	22	[	[	-LRB-
cord-344835-iivry1ou	87	23	50	50	CD
cord-344835-iivry1ou	87	24	]	]	-RRB-
cord-344835-iivry1ou	87	25	.	.	.
cord-344835-iivry1ou	88	1	Epidemiologists	epidemiologist	NNS
cord-344835-iivry1ou	88	2	have	have	VBP
cord-344835-iivry1ou	88	3	linked	link	VBN
cord-344835-iivry1ou	88	4	ambient	ambient	JJ
cord-344835-iivry1ou	88	5	particulate	particulate	NN
cord-344835-iivry1ou	88	6	air	air	NN
cord-344835-iivry1ou	88	7	pollution	pollution	NN
cord-344835-iivry1ou	88	8	(	(	-LRB-
cord-344835-iivry1ou	88	9	PM	pm	NN
cord-344835-iivry1ou	88	10	)	)	-RRB-
cord-344835-iivry1ou	88	11	exposure	exposure	NN
cord-344835-iivry1ou	88	12	with	with	IN
cord-344835-iivry1ou	88	13	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	88	14	of	of	IN
cord-344835-iivry1ou	88	15	pre	pre	JJ
cord-344835-iivry1ou	88	16	-	-	JJ
cord-344835-iivry1ou	88	17	existing	existing	JJ
cord-344835-iivry1ou	88	18	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	88	19	diseases	disease	NNS
cord-344835-iivry1ou	88	20	,	,	,
cord-344835-iivry1ou	88	21	such	such	JJ
cord-344835-iivry1ou	88	22	as	as	IN
cord-344835-iivry1ou	88	23	COPD	COPD	NNP
cord-344835-iivry1ou	88	24	[	[	-LRB-
cord-344835-iivry1ou	88	25	53	53	CD
cord-344835-iivry1ou	88	26	]	]	-RRB-
cord-344835-iivry1ou	88	27	.	.	.
cord-344835-iivry1ou	89	1	PM	pm	NN
cord-344835-iivry1ou	89	2	-	-	HYPH
cord-344835-iivry1ou	89	3	mediated	mediate	VBN
cord-344835-iivry1ou	89	4	enhancement	enhancement	NN
cord-344835-iivry1ou	89	5	of	of	IN
cord-344835-iivry1ou	89	6	airway	airway	NN
cord-344835-iivry1ou	89	7	inflammation	inflammation	NN
cord-344835-iivry1ou	89	8	is	be	VBZ
cord-344835-iivry1ou	89	9	a	a	DT
cord-344835-iivry1ou	89	10	central	central	JJ
cord-344835-iivry1ou	89	11	pathogenetic	pathogenetic	JJ
cord-344835-iivry1ou	89	12	mechanism	mechanism	NN
cord-344835-iivry1ou	89	13	by	by	IN
cord-344835-iivry1ou	89	14	which	which	WDT
cord-344835-iivry1ou	89	15	PM	pm	NN
cord-344835-iivry1ou	89	16	exposure	exposure	NN
cord-344835-iivry1ou	89	17	leads	lead	VBZ
cord-344835-iivry1ou	89	18	to	to	IN
cord-344835-iivry1ou	89	19	exacerbation	exacerbation	NN
cord-344835-iivry1ou	89	20	of	of	IN
cord-344835-iivry1ou	89	21	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	89	22	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	89	23	diseases	disease	NNS
cord-344835-iivry1ou	89	24	[	[	-LRB-
cord-344835-iivry1ou	89	25	54	54	CD
cord-344835-iivry1ou	89	26	]	]	-RRB-
cord-344835-iivry1ou	89	27	[	[	-LRB-
cord-344835-iivry1ou	89	28	55	55	CD
cord-344835-iivry1ou	89	29	]	]	-RRB-
cord-344835-iivry1ou	89	30	[	[	-LRB-
cord-344835-iivry1ou	89	31	56	56	CD
cord-344835-iivry1ou	89	32	]	]	-RRB-
cord-344835-iivry1ou	89	33	.	.	.
cord-344835-iivry1ou	90	1	It	-PRON-	PRP
cord-344835-iivry1ou	90	2	has	have	VBZ
cord-344835-iivry1ou	90	3	been	be	VBN
cord-344835-iivry1ou	90	4	suggested	suggest	VBN
cord-344835-iivry1ou	90	5	that	that	IN
cord-344835-iivry1ou	90	6	PM	PM	NNP
cord-344835-iivry1ou	90	7	exposure	exposure	NN
cord-344835-iivry1ou	90	8	induces	induce	VBZ
cord-344835-iivry1ou	90	9	lung	lung	NN
cord-344835-iivry1ou	90	10	inflam	inflam	NNP
cord-344835-iivry1ou	90	11	-	-	HYPH
cord-344835-iivry1ou	90	12	mation	mation	NNP
cord-344835-iivry1ou	90	13	by	by	IN
cord-344835-iivry1ou	90	14	an	an	DT
cord-344835-iivry1ou	90	15	increase	increase	NN
cord-344835-iivry1ou	90	16	in	in	IN
cord-344835-iivry1ou	90	17	Reactive	Reactive	NNP
cord-344835-iivry1ou	90	18	Oxygen	Oxygen	NNP
cord-344835-iivry1ou	90	19	Species	Species	NNP
cord-344835-iivry1ou	90	20	[	[	-LRB-
cord-344835-iivry1ou	90	21	57	57	CD
cord-344835-iivry1ou	90	22	,	,	,
cord-344835-iivry1ou	90	23	58	58	CD
cord-344835-iivry1ou	90	24	]	]	-RRB-
cord-344835-iivry1ou	90	25	.	.	.
cord-344835-iivry1ou	91	1	To	to	IN
cord-344835-iivry1ou	91	2	the	the	DT
cord-344835-iivry1ou	91	3	best	good	JJS
cord-344835-iivry1ou	91	4	of	of	IN
cord-344835-iivry1ou	91	5	our	-PRON-	PRP$
cord-344835-iivry1ou	91	6	knowledge	knowledge	NN
cord-344835-iivry1ou	91	7	there	there	EX
cord-344835-iivry1ou	91	8	are	be	VBP
cord-344835-iivry1ou	91	9	no	no	DT
cord-344835-iivry1ou	91	10	in	in	IN
cord-344835-iivry1ou	91	11	vivo	vivo	NN
cord-344835-iivry1ou	91	12	studies	study	NNS
cord-344835-iivry1ou	91	13	on	on	IN
cord-344835-iivry1ou	91	14	the	the	DT
cord-344835-iivry1ou	91	15	effect	effect	NN
cord-344835-iivry1ou	91	16	of	of	IN
cord-344835-iivry1ou	91	17	PM	pm	NN
cord-344835-iivry1ou	91	18	exposure	exposure	NN
cord-344835-iivry1ou	91	19	on	on	IN
cord-344835-iivry1ou	91	20	airway	airway	JJ
cord-344835-iivry1ou	91	21	inflammation	inflammation	NN
cord-344835-iivry1ou	91	22	in	in	IN
cord-344835-iivry1ou	91	23	COPD	COPD	NNP
cord-344835-iivry1ou	91	24	patients	patient	NNS
cord-344835-iivry1ou	91	25	.	.	.
cord-344835-iivry1ou	92	1	There	there	EX
cord-344835-iivry1ou	92	2	is	be	VBZ
cord-344835-iivry1ou	92	3	also	also	RB
cord-344835-iivry1ou	92	4	lack	lack	NN
cord-344835-iivry1ou	92	5	of	of	IN
cord-344835-iivry1ou	92	6	information	information	NN
cord-344835-iivry1ou	92	7	on	on	IN
cord-344835-iivry1ou	92	8	airway	airway	JJ
cord-344835-iivry1ou	92	9	inflammation	inflammation	NN
cord-344835-iivry1ou	92	10	during	during	IN
cord-344835-iivry1ou	92	11	PM	PM	NNP
cord-344835-iivry1ou	92	12	exposure	exposure	NN
cord-344835-iivry1ou	92	13	induced	induce	VBN
cord-344835-iivry1ou	92	14	COPD	COPD	NNP
cord-344835-iivry1ou	92	15	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	92	16	,	,	,
cord-344835-iivry1ou	92	17	which	which	WDT
cord-344835-iivry1ou	92	18	may	may	MD
cord-344835-iivry1ou	92	19	be	be	VB
cord-344835-iivry1ou	92	20	due	due	JJ
cord-344835-iivry1ou	92	21	to	to	IN
cord-344835-iivry1ou	92	22	difficulties	difficulty	NNS
cord-344835-iivry1ou	92	23	in	in	IN
cord-344835-iivry1ou	92	24	defining	define	VBG
cord-344835-iivry1ou	92	25	such	such	JJ
cord-344835-iivry1ou	92	26	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	92	27	.	.	.
cord-344835-iivry1ou	93	1	Trolox	trolox	JJ
cord-344835-iivry1ou	93	2	equivalent	equivalent	JJ
cord-344835-iivry1ou	93	3	antioxidant	antioxidant	NN
cord-344835-iivry1ou	93	4	capacity	capacity	NN
cord-344835-iivry1ou	93	5	is	be	VBZ
cord-344835-iivry1ou	93	6	decreased	decrease	VBN
cord-344835-iivry1ou	93	7	in	in	IN
cord-344835-iivry1ou	93	8	patients	patient	NNS
cord-344835-iivry1ou	93	9	presenting	present	VBG
cord-344835-iivry1ou	93	10	with	with	IN
cord-344835-iivry1ou	93	11	acute	acute	JJ
cord-344835-iivry1ou	93	12	exacerbation	exacerbation	NN
cord-344835-iivry1ou	93	13	of	of	IN
cord-344835-iivry1ou	93	14	COPD	COPD	NNP
cord-344835-iivry1ou	93	15	[	[	-LRB-
cord-344835-iivry1ou	93	16	59	59	CD
cord-344835-iivry1ou	93	17	]	]	-RRB-
cord-344835-iivry1ou	93	18	.	.	.
cord-344835-iivry1ou	94	1	Recent	recent	JJ
cord-344835-iivry1ou	94	2	reports	report	NNS
cord-344835-iivry1ou	94	3	suggest	suggest	VBP
cord-344835-iivry1ou	94	4	that	that	IN
cord-344835-iivry1ou	94	5	8-isoprostane	8-isoprostane	CD
cord-344835-iivry1ou	94	6	levels	level	NNS
cord-344835-iivry1ou	94	7	are	be	VBP
cord-344835-iivry1ou	94	8	increased	increase	VBN
cord-344835-iivry1ou	94	9	in	in	IN
cord-344835-iivry1ou	94	10	exhaled	exhale	VBN
cord-344835-iivry1ou	94	11	breath	breath	NN
cord-344835-iivry1ou	94	12	condensate	condensate	NN
cord-344835-iivry1ou	94	13	of	of	IN
cord-344835-iivry1ou	94	14	COPD	COPD	NNP
cord-344835-iivry1ou	94	15	patients	patient	NNS
cord-344835-iivry1ou	94	16	during	during	IN
cord-344835-iivry1ou	94	17	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	94	18	,	,	,
cord-344835-iivry1ou	94	19	while	while	IN
cord-344835-iivry1ou	94	20	levels	level	NNS
cord-344835-iivry1ou	94	21	of	of	IN
cord-344835-iivry1ou	94	22	the	the	DT
cord-344835-iivry1ou	94	23	antioxidant	antioxidant	JJ
cord-344835-iivry1ou	94	24	enzyme	enzyme	NN
cord-344835-iivry1ou	94	25	glutathione(GSH	glutathione(GSH	NNP
cord-344835-iivry1ou	94	26	)	)	-RRB-
cord-344835-iivry1ou	94	27	in	in	IN
cord-344835-iivry1ou	94	28	bronchoalveolar	bronchoalveolar	NNP
cord-344835-iivry1ou	94	29	lavage	lavage	NN
cord-344835-iivry1ou	94	30	fluid	fluid	NN
cord-344835-iivry1ou	94	31	are	be	VBP
cord-344835-iivry1ou	94	32	decreased	decrease	VBN
cord-344835-iivry1ou	94	33	[	[	-LRB-
cord-344835-iivry1ou	94	34	60	60	CD
cord-344835-iivry1ou	94	35	,	,	,
cord-344835-iivry1ou	94	36	61	61	CD
cord-344835-iivry1ou	94	37	]	]	-RRB-
cord-344835-iivry1ou	94	38	.	.	.
cord-344835-iivry1ou	95	1	Oxidative	oxidative	JJ
cord-344835-iivry1ou	95	2	stress	stress	NN
cord-344835-iivry1ou	95	3	may	may	MD
cord-344835-iivry1ou	95	4	be	be	VB
cord-344835-iivry1ou	95	5	closely	closely	RB
cord-344835-iivry1ou	95	6	associated	associate	VBN
cord-344835-iivry1ou	95	7	to	to	IN
cord-344835-iivry1ou	95	8	increased	increase	VBN
cord-344835-iivry1ou	95	9	inflammation	inflammation	NN
cord-344835-iivry1ou	95	10	during	during	IN
cord-344835-iivry1ou	95	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	95	12	[	[	-LRB-
cord-344835-iivry1ou	95	13	60	60	CD
cord-344835-iivry1ou	95	14	,	,	,
cord-344835-iivry1ou	95	15	62	62	CD
cord-344835-iivry1ou	95	16	]	]	-RRB-
cord-344835-iivry1ou	95	17	.	.	.
cord-344835-iivry1ou	96	1	Oxidant	oxidant	JJ
cord-344835-iivry1ou	96	2	stimuli	stimulus	NNS
cord-344835-iivry1ou	96	3	induce	induce	VBP
cord-344835-iivry1ou	96	4	cellular	cellular	JJ
cord-344835-iivry1ou	96	5	expression	expression	NN
cord-344835-iivry1ou	96	6	of	of	IN
cord-344835-iivry1ou	96	7	inducible	inducible	JJ
cord-344835-iivry1ou	96	8	nitric	nitric	NN
cord-344835-iivry1ou	96	9	oxide	oxide	NN
cord-344835-iivry1ou	96	10	synthase	synthase	NN
cord-344835-iivry1ou	96	11	and	and	CC
cord-344835-iivry1ou	96	12	heme	heme	NN
cord-344835-iivry1ou	96	13	-	-	HYPH
cord-344835-iivry1ou	96	14	oxygenase-1(HO-1	oxygenase-1(HO-1	NNP
cord-344835-iivry1ou	96	15	)	)	-RRB-
cord-344835-iivry1ou	96	16	and	and	CC
cord-344835-iivry1ou	96	17	increase	increase	VB
cord-344835-iivry1ou	96	18	nitrotyrosine	nitrotyrosine	JJ
cord-344835-iivry1ou	96	19	formation	formation	NN
cord-344835-iivry1ou	96	20	.	.	.
cord-344835-iivry1ou	97	1	We	-PRON-	PRP
cord-344835-iivry1ou	97	2	have	have	VBP
cord-344835-iivry1ou	97	3	shown	show	VBN
cord-344835-iivry1ou	97	4	that	that	IN
cord-344835-iivry1ou	97	5	there	there	EX
cord-344835-iivry1ou	97	6	is	be	VBZ
cord-344835-iivry1ou	97	7	increased	increase	VBN
cord-344835-iivry1ou	97	8	HO-1	HO-1	NNP
cord-344835-iivry1ou	97	9	expression	expression	NN
cord-344835-iivry1ou	97	10	and	and	CC
cord-344835-iivry1ou	97	11	nitrotyrosine	nitrotyrosine	JJ
cord-344835-iivry1ou	97	12	formation	formation	NN
cord-344835-iivry1ou	97	13	in	in	IN
cord-344835-iivry1ou	97	14	the	the	DT
cord-344835-iivry1ou	97	15	airways	airway	NNS
cord-344835-iivry1ou	97	16	of	of	IN
cord-344835-iivry1ou	97	17	COPD	COPD	NNP
cord-344835-iivry1ou	97	18	patients	patient	NNS
cord-344835-iivry1ou	97	19	during	during	IN
cord-344835-iivry1ou	97	20	severe	severe	JJ
cord-344835-iivry1ou	97	21	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	97	22	relatively	relatively	RB
cord-344835-iivry1ou	97	23	to	to	IN
cord-344835-iivry1ou	97	24	stable	stable	JJ
cord-344835-iivry1ou	97	25	state	state	NN
cord-344835-iivry1ou	97	26	and	and	CC
cord-344835-iivry1ou	97	27	that	that	IN
cord-344835-iivry1ou	97	28	this	this	DT
cord-344835-iivry1ou	97	29	is	be	VBZ
cord-344835-iivry1ou	97	30	accompanied	accompany	VBN
cord-344835-iivry1ou	97	31	by	by	IN
cord-344835-iivry1ou	97	32	an	an	DT
cord-344835-iivry1ou	97	33	increase	increase	NN
cord-344835-iivry1ou	97	34	in	in	IN
cord-344835-iivry1ou	97	35	indices	index	NNS
cord-344835-iivry1ou	97	36	of	of	IN
cord-344835-iivry1ou	97	37	neutrophilic	neutrophilic	JJ
cord-344835-iivry1ou	97	38	inflammation	inflammation	NN
cord-344835-iivry1ou	97	39	,	,	,
cord-344835-iivry1ou	97	40	i.e.	i.e.	FW
cord-344835-iivry1ou	97	41	neutrophil	neutrophil	NN
cord-344835-iivry1ou	97	42	numbers	number	NNS
cord-344835-iivry1ou	97	43	,	,	,
cord-344835-iivry1ou	97	44	MPO	MPO	NNP
cord-344835-iivry1ou	97	45	and	and	CC
cord-344835-iivry1ou	97	46	IL-8	IL-8	NNP
cord-344835-iivry1ou	97	47	levels	level	NNS
cord-344835-iivry1ou	97	48	[	[	-LRB-
cord-344835-iivry1ou	97	49	62	62	CD
cord-344835-iivry1ou	97	50	]	]	-RRB-
cord-344835-iivry1ou	97	51	.	.	.
cord-344835-iivry1ou	98	1	Evidence	evidence	NN
cord-344835-iivry1ou	98	2	for	for	IN
cord-344835-iivry1ou	98	3	a	a	DT
cord-344835-iivry1ou	98	4	close	close	JJ
cord-344835-iivry1ou	98	5	association	association	NN
cord-344835-iivry1ou	98	6	between	between	IN
cord-344835-iivry1ou	98	7	oxidative	oxidative	JJ
cord-344835-iivry1ou	98	8	stress	stress	NN
cord-344835-iivry1ou	98	9	,	,	,
cord-344835-iivry1ou	98	10	airway	airway	NNP
cord-344835-iivry1ou	98	11	neutrophilia	neutrophilia	NNP
cord-344835-iivry1ou	98	12	and	and	CC
cord-344835-iivry1ou	98	13	increased	increase	VBN
cord-344835-iivry1ou	98	14	IL-8	IL-8	NNP
cord-344835-iivry1ou	98	15	during	during	IN
cord-344835-iivry1ou	98	16	severe	severe	JJ
cord-344835-iivry1ou	98	17	COPD	COPD	NNP
cord-344835-iivry1ou	98	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	98	19	is	be	VBZ
cord-344835-iivry1ou	98	20	also	also	RB
cord-344835-iivry1ou	98	21	supported	support	VBN
cord-344835-iivry1ou	98	22	by	by	IN
cord-344835-iivry1ou	98	23	Drost	Drost	NNP
cord-344835-iivry1ou	98	24	et	et	FW
cord-344835-iivry1ou	98	25	al	al	NNP
cord-344835-iivry1ou	98	26	[	[	-LRB-
cord-344835-iivry1ou	98	27	60	60	CD
cord-344835-iivry1ou	98	28	]	]	-RRB-
cord-344835-iivry1ou	98	29	.	.	.
cord-344835-iivry1ou	99	1	A	a	DT
cord-344835-iivry1ou	99	2	certain	certain	JJ
cord-344835-iivry1ou	99	3	limitation	limitation	NN
cord-344835-iivry1ou	99	4	in	in	IN
cord-344835-iivry1ou	99	5	the	the	DT
cord-344835-iivry1ou	99	6	study	study	NN
cord-344835-iivry1ou	99	7	by	by	IN
cord-344835-iivry1ou	99	8	Drost	Drost	NNP
cord-344835-iivry1ou	99	9	et	et	FW
cord-344835-iivry1ou	99	10	al	al	NNP
cord-344835-iivry1ou	99	11	is	be	VBZ
cord-344835-iivry1ou	99	12	the	the	DT
cord-344835-iivry1ou	99	13	fact	fact	NN
cord-344835-iivry1ou	99	14	that	that	IN
cord-344835-iivry1ou	99	15	different	different	JJ
cord-344835-iivry1ou	99	16	patients	patient	NNS
cord-344835-iivry1ou	99	17	were	be	VBD
cord-344835-iivry1ou	99	18	examined	examine	VBN
cord-344835-iivry1ou	99	19	on	on	IN
cord-344835-iivry1ou	99	20	exacerbation	exacerbation	NN
cord-344835-iivry1ou	99	21	and	and	CC
cord-344835-iivry1ou	99	22	on	on	IN
cord-344835-iivry1ou	99	23	stable	stable	JJ
cord-344835-iivry1ou	99	24	state	state	NN
cord-344835-iivry1ou	99	25	.	.	.
cord-344835-iivry1ou	100	1	Oxidative	oxidative	JJ
cord-344835-iivry1ou	100	2	stress	stress	NN
cord-344835-iivry1ou	100	3	induces	induce	VBZ
cord-344835-iivry1ou	100	4	the	the	DT
cord-344835-iivry1ou	100	5	transcription	transcription	NN
cord-344835-iivry1ou	100	6	of	of	IN
cord-344835-iivry1ou	100	7	various	various	JJ
cord-344835-iivry1ou	100	8	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	100	9	factors	factor	NNS
cord-344835-iivry1ou	100	10	,	,	,
cord-344835-iivry1ou	100	11	such	such	JJ
cord-344835-iivry1ou	100	12	as	as	IN
cord-344835-iivry1ou	100	13	nuclear	nuclear	JJ
cord-344835-iivry1ou	100	14	factor	factor	NN
cord-344835-iivry1ou	100	15	-	-	:
cord-344835-iivry1ou	100	16	kappaB	kappaB	NNP
cord-344835-iivry1ou	100	17	(	(	-LRB-
cord-344835-iivry1ou	100	18	NF	nf	NN
cord-344835-iivry1ou	100	19	-	-	HYPH
cord-344835-iivry1ou	100	20	κB	κB	NNP
cord-344835-iivry1ou	100	21	)	)	-RRB-
cord-344835-iivry1ou	100	22	and	and	CC
cord-344835-iivry1ou	100	23	activator	activator	NN
cord-344835-iivry1ou	100	24	protein-1	protein-1	NNP
cord-344835-iivry1ou	100	25	(	(	-LRB-
cord-344835-iivry1ou	100	26	AP-1	AP-1	NNP
cord-344835-iivry1ou	100	27	)	)	-RRB-
cord-344835-iivry1ou	100	28	[	[	-LRB-
cord-344835-iivry1ou	100	29	63	63	CD
cord-344835-iivry1ou	100	30	]	]	-RRB-
cord-344835-iivry1ou	100	31	.	.	.
cord-344835-iivry1ou	101	1	It	-PRON-	PRP
cord-344835-iivry1ou	101	2	has	have	VBZ
cord-344835-iivry1ou	101	3	been	be	VBN
cord-344835-iivry1ou	101	4	shown	show	VBN
cord-344835-iivry1ou	101	5	that	that	IN
cord-344835-iivry1ou	101	6	NF	nf	NN
cord-344835-iivry1ou	101	7	-	-	HYPH
cord-344835-iivry1ou	101	8	κB	κb	CD
cord-344835-iivry1ou	101	9	DNA	dna	NN
cord-344835-iivry1ou	101	10	binding	binding	NN
cord-344835-iivry1ou	101	11	in	in	IN
cord-344835-iivry1ou	101	12	sputum	sputum	JJ
cord-344835-iivry1ou	101	13	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	101	14	cells	cell	NNS
cord-344835-iivry1ou	101	15	is	be	VBZ
cord-344835-iivry1ou	101	16	increased	increase	VBN
cord-344835-iivry1ou	101	17	during	during	IN
cord-344835-iivry1ou	101	18	COPD	COPD	NNP
cord-344835-iivry1ou	101	19	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	101	20	[	[	-LRB-
cord-344835-iivry1ou	101	21	64	64	CD
cord-344835-iivry1ou	101	22	]	]	-RRB-
cord-344835-iivry1ou	101	23	.	.	.
cord-344835-iivry1ou	102	1	Other	other	JJ
cord-344835-iivry1ou	102	2	investigators	investigator	NNS
cord-344835-iivry1ou	102	3	have	have	VBP
cord-344835-iivry1ou	102	4	reported	report	VBN
cord-344835-iivry1ou	102	5	increased	increase	VBN
cord-344835-iivry1ou	102	6	nuclear	nuclear	JJ
cord-344835-iivry1ou	102	7	localisation	localisation	NN
cord-344835-iivry1ou	102	8	of	of	IN
cord-344835-iivry1ou	102	9	p65	p65	NNP
cord-344835-iivry1ou	102	10	,	,	,
cord-344835-iivry1ou	102	11	which	which	WDT
cord-344835-iivry1ou	102	12	is	be	VBZ
cord-344835-iivry1ou	102	13	a	a	DT
cord-344835-iivry1ou	102	14	signal	signal	NN
cord-344835-iivry1ou	102	15	of	of	IN
cord-344835-iivry1ou	102	16	NF	nf	NN
cord-344835-iivry1ou	102	17	-	-	HYPH
cord-344835-iivry1ou	102	18	κB	κb	CD
cord-344835-iivry1ou	102	19	activation	activation	NN
cord-344835-iivry1ou	102	20	,	,	,
cord-344835-iivry1ou	102	21	in	in	IN
cord-344835-iivry1ou	102	22	sputum	sputum	NN
cord-344835-iivry1ou	102	23	macrophages	macrophage	NNS
cord-344835-iivry1ou	102	24	during	during	IN
cord-344835-iivry1ou	102	25	COPD	COPD	NNP
cord-344835-iivry1ou	102	26	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	102	27	[	[	-LRB-
cord-344835-iivry1ou	102	28	65	65	CD
cord-344835-iivry1ou	102	29	]	]	-RRB-
cord-344835-iivry1ou	102	30	.	.	.
cord-344835-iivry1ou	103	1	NF	NF	NNP
cord-344835-iivry1ou	103	2	-	-	HYPH
cord-344835-iivry1ou	103	3	κB	κB	NNP
cord-344835-iivry1ou	103	4	is	be	VBZ
cord-344835-iivry1ou	103	5	important	important	JJ
cord-344835-iivry1ou	103	6	for	for	IN
cord-344835-iivry1ou	103	7	transcription	transcription	NN
cord-344835-iivry1ou	103	8	of	of	IN
cord-344835-iivry1ou	103	9	IL-8	il-8	NN
cord-344835-iivry1ou	103	10	gene	gene	NN
cord-344835-iivry1ou	103	11	and	and	CC
cord-344835-iivry1ou	103	12	oxidative	oxidative	JJ
cord-344835-iivry1ou	103	13	stress	stress	NN
cord-344835-iivry1ou	103	14	may	may	MD
cord-344835-iivry1ou	103	15	induce	induce	VB
cord-344835-iivry1ou	103	16	or	or	CC
cord-344835-iivry1ou	103	17	amplify	amplify	VB
cord-344835-iivry1ou	103	18	airway	airway	NN
cord-344835-iivry1ou	103	19	neutrophilia	neutrophilia	NNS
cord-344835-iivry1ou	103	20	by	by	IN
cord-344835-iivry1ou	103	21	inducing	induce	VBG
cord-344835-iivry1ou	103	22	the	the	DT
cord-344835-iivry1ou	103	23	transcription	transcription	NN
cord-344835-iivry1ou	103	24	of	of	IN
cord-344835-iivry1ou	103	25	IL-8	il-8	NN
cord-344835-iivry1ou	103	26	gene	gene	NN
cord-344835-iivry1ou	103	27	[	[	-LRB-
cord-344835-iivry1ou	103	28	66	66	CD
cord-344835-iivry1ou	103	29	]	]	-RRB-
cord-344835-iivry1ou	103	30	.	.	.
cord-344835-iivry1ou	104	1	In	in	IN
cord-344835-iivry1ou	104	2	support	support	NN
cord-344835-iivry1ou	104	3	of	of	IN
cord-344835-iivry1ou	104	4	this	this	DT
cord-344835-iivry1ou	104	5	hypothesis	hypothesis	NN
cord-344835-iivry1ou	104	6	both	both	CC
cord-344835-iivry1ou	104	7	we	-PRON-	PRP
cord-344835-iivry1ou	104	8	and	and	CC
cord-344835-iivry1ou	104	9	Drost	Drost	NNP
cord-344835-iivry1ou	104	10	et	et	FW
cord-344835-iivry1ou	104	11	al	al	NNP
cord-344835-iivry1ou	104	12	have	have	VBP
cord-344835-iivry1ou	104	13	found	find	VBN
cord-344835-iivry1ou	104	14	increased	increase	VBN
cord-344835-iivry1ou	104	15	IL-8	il-8	NN
cord-344835-iivry1ou	104	16	levels	level	NNS
cord-344835-iivry1ou	104	17	and	and	CC
cord-344835-iivry1ou	104	18	neutrophil	neutrophil	NN
cord-344835-iivry1ou	104	19	numbers	number	NNS
cord-344835-iivry1ou	104	20	associated	associate	VBN
cord-344835-iivry1ou	104	21	with	with	IN
cord-344835-iivry1ou	104	22	increased	increase	VBN
cord-344835-iivry1ou	104	23	oxidative	oxidative	JJ
cord-344835-iivry1ou	104	24	stress	stress	NN
cord-344835-iivry1ou	104	25	on	on	IN
cord-344835-iivry1ou	104	26	severe	severe	JJ
cord-344835-iivry1ou	104	27	COPD	COPD	NNP
cord-344835-iivry1ou	104	28	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	104	29	[	[	-LRB-
cord-344835-iivry1ou	104	30	60	60	CD
cord-344835-iivry1ou	104	31	,	,	,
cord-344835-iivry1ou	104	32	62	62	CD
cord-344835-iivry1ou	104	33	]	]	-RRB-
cord-344835-iivry1ou	104	34	.	.	.
cord-344835-iivry1ou	105	1	Activated	activate	VBN
cord-344835-iivry1ou	105	2	neutrophils	neutrophil	NNS
cord-344835-iivry1ou	105	3	and	and	CC
cord-344835-iivry1ou	105	4	other	other	JJ
cord-344835-iivry1ou	105	5	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	105	6	cells	cell	NNS
cord-344835-iivry1ou	105	7	can	can	MD
cord-344835-iivry1ou	105	8	in	in	IN
cord-344835-iivry1ou	105	9	turn	turn	NN
cord-344835-iivry1ou	105	10	release	release	VB
cord-344835-iivry1ou	105	11	reactive	reactive	JJ
cord-344835-iivry1ou	105	12	oxygen	oxygen	NN
cord-344835-iivry1ou	105	13	species	specie	NNS
cord-344835-iivry1ou	105	14	and	and	CC
cord-344835-iivry1ou	105	15	increase	increase	VB
cord-344835-iivry1ou	105	16	airway	airway	NN
cord-344835-iivry1ou	105	17	oxidative	oxidative	JJ
cord-344835-iivry1ou	105	18	stress	stress	NN
cord-344835-iivry1ou	105	19	.	.	.
cord-344835-iivry1ou	106	1	Because	because	IN
cord-344835-iivry1ou	106	2	oxidative	oxidative	JJ
cord-344835-iivry1ou	106	3	stress	stress	NN
cord-344835-iivry1ou	106	4	can	can	MD
cord-344835-iivry1ou	106	5	induce	induce	VB
cord-344835-iivry1ou	106	6	inflammation	inflammation	NN
cord-344835-iivry1ou	106	7	and	and	CC
cord-344835-iivry1ou	106	8	vice	vice	NN
cord-344835-iivry1ou	106	9	versa	versa	RB
cord-344835-iivry1ou	106	10	,	,	,
cord-344835-iivry1ou	106	11	it	-PRON-	PRP
cord-344835-iivry1ou	106	12	is	be	VBZ
cord-344835-iivry1ou	106	13	not	not	RB
cord-344835-iivry1ou	106	14	clear	clear	JJ
cord-344835-iivry1ou	106	15	which	which	WDT
cord-344835-iivry1ou	106	16	of	of	IN
cord-344835-iivry1ou	106	17	the	the	DT
cord-344835-iivry1ou	106	18	two	two	CD
cord-344835-iivry1ou	106	19	,	,	,
cord-344835-iivry1ou	106	20	oxidative	oxidative	JJ
cord-344835-iivry1ou	106	21	stress	stress	NN
cord-344835-iivry1ou	106	22	or	or	CC
cord-344835-iivry1ou	106	23	inflammation	inflammation	NN
cord-344835-iivry1ou	106	24	,	,	,
cord-344835-iivry1ou	106	25	is	be	VBZ
cord-344835-iivry1ou	106	26	primarily	primarily	RB
cord-344835-iivry1ou	106	27	involved	involve	VBN
cord-344835-iivry1ou	106	28	in	in	IN
cord-344835-iivry1ou	106	29	the	the	DT
cord-344835-iivry1ou	106	30	mechanisms	mechanism	NNS
cord-344835-iivry1ou	106	31	of	of	IN
cord-344835-iivry1ou	106	32	COPD	COPD	NNP
cord-344835-iivry1ou	106	33	exacerbations-[the	exacerbations-[the	JJ
cord-344835-iivry1ou	106	34	chicken	chicken	NN
cord-344835-iivry1ou	106	35	and	and	CC
cord-344835-iivry1ou	106	36	egg	egg	NN
cord-344835-iivry1ou	106	37	problem	problem	NN
cord-344835-iivry1ou	106	38	]	]	-RRB-
cord-344835-iivry1ou	106	39	.	.	.
cord-344835-iivry1ou	107	1	Alterations	alteration	NNS
cord-344835-iivry1ou	107	2	in	in	IN
cord-344835-iivry1ou	107	3	innate	innate	JJ
cord-344835-iivry1ou	107	4	and	and	CC
cord-344835-iivry1ou	107	5	adaptive	adaptive	JJ
cord-344835-iivry1ou	107	6	immunity	immunity	NN
cord-344835-iivry1ou	107	7	are	be	VBP
cord-344835-iivry1ou	107	8	implicated	implicate	VBN
cord-344835-iivry1ou	107	9	in	in	IN
cord-344835-iivry1ou	107	10	COPD	COPD	NNP
cord-344835-iivry1ou	107	11	pathogenesis	pathogenesis	NN
cord-344835-iivry1ou	107	12	[	[	-LRB-
cord-344835-iivry1ou	107	13	67	67	CD
cord-344835-iivry1ou	107	14	]	]	-RRB-
cord-344835-iivry1ou	107	15	.	.	.
cord-344835-iivry1ou	108	1	Evidence	evidence	NN
cord-344835-iivry1ou	108	2	favouring	favour	VBG
cord-344835-iivry1ou	108	3	participation	participation	NN
cord-344835-iivry1ou	108	4	of	of	IN
cord-344835-iivry1ou	108	5	the	the	DT
cord-344835-iivry1ou	108	6	adaptive	adaptive	JJ
cord-344835-iivry1ou	108	7	immune	immune	JJ
cord-344835-iivry1ou	108	8	response	response	NN
cord-344835-iivry1ou	108	9	in	in	IN
cord-344835-iivry1ou	108	10	COPD	COPD	NNP
cord-344835-iivry1ou	108	11	includes	include	VBZ
cord-344835-iivry1ou	108	12	the	the	DT
cord-344835-iivry1ou	108	13	several	several	JJ
cord-344835-iivry1ou	108	14	reports	report	NNS
cord-344835-iivry1ou	108	15	of	of	IN
cord-344835-iivry1ou	108	16	increased	increase	VBN
cord-344835-iivry1ou	108	17	numbers	number	NNS
cord-344835-iivry1ou	108	18	of	of	IN
cord-344835-iivry1ou	108	19	Tlymphocytes	Tlymphocytes	NNPS
cord-344835-iivry1ou	108	20	,	,	,
cord-344835-iivry1ou	108	21	specifically	specifically	RB
cord-344835-iivry1ou	108	22	CD8+ve	CD8+ve	NNP
cord-344835-iivry1ou	108	23	T	T	NNP
cord-344835-iivry1ou	108	24	-	-	HYPH
cord-344835-iivry1ou	108	25	cells	cell	NNS
cord-344835-iivry1ou	108	26	with	with	IN
cord-344835-iivry1ou	108	27	a	a	DT
cord-344835-iivry1ou	108	28	"	"	``
cord-344835-iivry1ou	108	29	type	type	NN
cord-344835-iivry1ou	108	30	1"profile	1"profile	CD
cord-344835-iivry1ou	108	31	[	[	-LRB-
cord-344835-iivry1ou	108	32	68	68	CD
cord-344835-iivry1ou	108	33	]	]	-RRB-
cord-344835-iivry1ou	108	34	[	[	-LRB-
cord-344835-iivry1ou	108	35	69	69	CD
cord-344835-iivry1ou	108	36	]	]	-RRB-
cord-344835-iivry1ou	108	37	[	[	-LRB-
cord-344835-iivry1ou	108	38	70	70	CD
cord-344835-iivry1ou	108	39	]	]	-RRB-
cord-344835-iivry1ou	108	40	[	[	-LRB-
cord-344835-iivry1ou	108	41	71	71	CD
cord-344835-iivry1ou	108	42	]	]	-RRB-
cord-344835-iivry1ou	108	43	.	.	.
cord-344835-iivry1ou	109	1	It	-PRON-	PRP
cord-344835-iivry1ou	109	2	is	be	VBZ
cord-344835-iivry1ou	109	3	still	still	RB
cord-344835-iivry1ou	109	4	unknown	unknown	JJ
cord-344835-iivry1ou	109	5	whether	whether	IN
cord-344835-iivry1ou	109	6	these	these	DT
cord-344835-iivry1ou	109	7	alterations	alteration	NNS
cord-344835-iivry1ou	109	8	are	be	VBP
cord-344835-iivry1ou	109	9	triggered	trigger	VBN
cord-344835-iivry1ou	109	10	by	by	IN
cord-344835-iivry1ou	109	11	cigarette	cigarette	NN
cord-344835-iivry1ou	109	12	smoking	smoking	NN
cord-344835-iivry1ou	109	13	,	,	,
cord-344835-iivry1ou	109	14	viral	viral	JJ
cord-344835-iivry1ou	109	15	infections	infection	NNS
cord-344835-iivry1ou	109	16	,	,	,
cord-344835-iivry1ou	109	17	or	or	CC
cord-344835-iivry1ou	109	18	there	there	EX
cord-344835-iivry1ou	109	19	is	be	VBZ
cord-344835-iivry1ou	109	20	a	a	DT
cord-344835-iivry1ou	109	21	genetic	genetic	JJ
cord-344835-iivry1ou	109	22	predisposal	predisposal	NN
cord-344835-iivry1ou	109	23	.	.	.
cord-344835-iivry1ou	110	1	We	-PRON-	PRP
cord-344835-iivry1ou	110	2	have	have	VBP
cord-344835-iivry1ou	110	3	recently	recently	RB
cord-344835-iivry1ou	110	4	shown	show	VBN
cord-344835-iivry1ou	110	5	that	that	IN
cord-344835-iivry1ou	110	6	CD8+ve	CD8+ve	NNP
cord-344835-iivry1ou	110	7	T	T	NNP
cord-344835-iivry1ou	110	8	lymphocytes	lymphocyte	NNS
cord-344835-iivry1ou	110	9	may	may	MD
cord-344835-iivry1ou	110	10	mediate	mediate	VB
cord-344835-iivry1ou	110	11	their	-PRON-	PRP$
cord-344835-iivry1ou	110	12	destructive	destructive	JJ
cord-344835-iivry1ou	110	13	effects	effect	NNS
cord-344835-iivry1ou	110	14	in	in	IN
cord-344835-iivry1ou	110	15	COPD	COPD	NNP
cord-344835-iivry1ou	110	16	through	through	IN
cord-344835-iivry1ou	110	17	increased	increase	VBN
cord-344835-iivry1ou	110	18	perforin	perforin	JJ
cord-344835-iivry1ou	110	19	expression	expression	NN
cord-344835-iivry1ou	110	20	and	and	CC
cord-344835-iivry1ou	110	21	cytotoxic	cytotoxic	JJ
cord-344835-iivry1ou	110	22	activity	activity	NN
cord-344835-iivry1ou	110	23	[	[	-LRB-
cord-344835-iivry1ou	110	24	72	72	CD
cord-344835-iivry1ou	110	25	]	]	-RRB-
cord-344835-iivry1ou	110	26	.	.	.
cord-344835-iivry1ou	111	1	It	-PRON-	PRP
cord-344835-iivry1ou	111	2	would	would	MD
cord-344835-iivry1ou	111	3	be	be	VB
cord-344835-iivry1ou	111	4	reasonable	reasonable	JJ
cord-344835-iivry1ou	111	5	to	to	TO
cord-344835-iivry1ou	111	6	assume	assume	VB
cord-344835-iivry1ou	111	7	that	that	IN
cord-344835-iivry1ou	111	8	lymphocytes	lymphocyte	NNS
cord-344835-iivry1ou	111	9	may	may	MD
cord-344835-iivry1ou	111	10	be	be	VB
cord-344835-iivry1ou	111	11	implicated	implicate	VBN
cord-344835-iivry1ou	111	12	in	in	IN
cord-344835-iivry1ou	111	13	the	the	DT
cord-344835-iivry1ou	111	14	mechanisms	mechanism	NNS
cord-344835-iivry1ou	111	15	of	of	IN
cord-344835-iivry1ou	111	16	increased	increase	VBN
cord-344835-iivry1ou	111	17	inflammation	inflammation	NN
cord-344835-iivry1ou	111	18	during	during	IN
cord-344835-iivry1ou	111	19	COPD	COPD	NNP
cord-344835-iivry1ou	111	20	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	111	21	.	.	.
cord-344835-iivry1ou	112	1	According	accord	VBG
cord-344835-iivry1ou	112	2	to	to	IN
cord-344835-iivry1ou	112	3	our	-PRON-	PRP$
cord-344835-iivry1ou	112	4	observations	observation	NNS
cord-344835-iivry1ou	112	5	changes	change	NNS
cord-344835-iivry1ou	112	6	in	in	IN
cord-344835-iivry1ou	112	7	lymphocyte	lymphocyte	NN
cord-344835-iivry1ou	112	8	subpopulations	subpopulation	NNS
cord-344835-iivry1ou	112	9	occur	occur	VBP
cord-344835-iivry1ou	112	10	during	during	IN
cord-344835-iivry1ou	112	11	severe	severe	JJ
cord-344835-iivry1ou	112	12	COPD	COPD	NNP
cord-344835-iivry1ou	112	13	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	112	14	[	[	-LRB-
cord-344835-iivry1ou	112	15	73	73	CD
cord-344835-iivry1ou	112	16	]	]	-RRB-
cord-344835-iivry1ou	112	17	.	.	.
cord-344835-iivry1ou	113	1	In	in	IN
cord-344835-iivry1ou	113	2	specific	specific	JJ
cord-344835-iivry1ou	113	3	,	,	,
cord-344835-iivry1ou	113	4	there	there	EX
cord-344835-iivry1ou	113	5	is	be	VBZ
cord-344835-iivry1ou	113	6	a	a	DT
cord-344835-iivry1ou	113	7	further	further	JJ
cord-344835-iivry1ou	113	8	increase	increase	NN
cord-344835-iivry1ou	113	9	in	in	IN
cord-344835-iivry1ou	113	10	CD8+ve	CD8+ve	NNP
cord-344835-iivry1ou	113	11	T	T	NNP
cord-344835-iivry1ou	113	12	cells	cell	NNS
cord-344835-iivry1ou	113	13	and	and	CC
cord-344835-iivry1ou	113	14	this	this	DT
cord-344835-iivry1ou	113	15	is	be	VBZ
cord-344835-iivry1ou	113	16	rather	rather	RB
cord-344835-iivry1ou	113	17	associated	associate	VBN
cord-344835-iivry1ou	113	18	with	with	IN
cord-344835-iivry1ou	113	19	increased	increase	VBN
cord-344835-iivry1ou	113	20	CD8+ve	CD8+ve	NNP
cord-344835-iivry1ou	113	21	type	type	NN
cord-344835-iivry1ou	113	22	2	2	CD
cord-344835-iivry1ou	113	23	cells	cell	NNS
cord-344835-iivry1ou	113	24	compared	compare	VBN
cord-344835-iivry1ou	113	25	to	to	IN
cord-344835-iivry1ou	113	26	type	type	NN
cord-344835-iivry1ou	113	27	1	1	CD
cord-344835-iivry1ou	113	28	.	.	.
cord-344835-iivry1ou	114	1	This	this	DT
cord-344835-iivry1ou	114	2	finding	finding	NN
cord-344835-iivry1ou	114	3	suggests	suggest	VBZ
cord-344835-iivry1ou	114	4	that	that	IN
cord-344835-iivry1ou	114	5	Tc1	tc1	CD
cord-344835-iivry1ou	114	6	and	and	CC
cord-344835-iivry1ou	114	7	Tc2	tc2	NN
cord-344835-iivry1ou	114	8	responses	response	NNS
cord-344835-iivry1ou	114	9	may	may	MD
cord-344835-iivry1ou	114	10	fluctuate	fluctuate	VB
cord-344835-iivry1ou	114	11	in	in	IN
cord-344835-iivry1ou	114	12	relation	relation	NN
cord-344835-iivry1ou	114	13	to	to	IN
cord-344835-iivry1ou	114	14	the	the	DT
cord-344835-iivry1ou	114	15	different	different	JJ
cord-344835-iivry1ou	114	16	phase	phase	NN
cord-344835-iivry1ou	114	17	(	(	-LRB-
cord-344835-iivry1ou	114	18	exacerbation	exacerbation	NN
cord-344835-iivry1ou	114	19	versus	versus	IN
cord-344835-iivry1ou	114	20	stable	stable	JJ
cord-344835-iivry1ou	114	21	state	state	NN
cord-344835-iivry1ou	114	22	)	)	-RRB-
cord-344835-iivry1ou	114	23	of	of	IN
cord-344835-iivry1ou	114	24	the	the	DT
cord-344835-iivry1ou	114	25	disease	disease	NN
cord-344835-iivry1ou	114	26	in	in	IN
cord-344835-iivry1ou	114	27	the	the	DT
cord-344835-iivry1ou	114	28	same	same	JJ
cord-344835-iivry1ou	114	29	patient	patient	NN
cord-344835-iivry1ou	114	30	.	.	.
cord-344835-iivry1ou	115	1	Similar	similar	JJ
cord-344835-iivry1ou	115	2	observations	observation	NNS
cord-344835-iivry1ou	115	3	have	have	VBP
cord-344835-iivry1ou	115	4	been	be	VBN
cord-344835-iivry1ou	115	5	made	make	VBN
cord-344835-iivry1ou	115	6	in	in	IN
cord-344835-iivry1ou	115	7	other	other	JJ
cord-344835-iivry1ou	115	8	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	115	9	diseases	disease	NNS
cord-344835-iivry1ou	115	10	[	[	-LRB-
cord-344835-iivry1ou	115	11	74	74	CD
cord-344835-iivry1ou	115	12	]	]	-RRB-
cord-344835-iivry1ou	115	13	.	.	.
cord-344835-iivry1ou	116	1	A	a	DT
cord-344835-iivry1ou	116	2	relative	relative	JJ
cord-344835-iivry1ou	116	3	increase	increase	NN
cord-344835-iivry1ou	116	4	of	of	IN
cord-344835-iivry1ou	116	5	Tc2	tc2	NN
cord-344835-iivry1ou	116	6	versus	versus	IN
cord-344835-iivry1ou	116	7	Tc1	tc1	CD
cord-344835-iivry1ou	116	8	cells	cell	NNS
cord-344835-iivry1ou	116	9	may	may	MD
cord-344835-iivry1ou	116	10	result	result	VB
cord-344835-iivry1ou	116	11	in	in	IN
cord-344835-iivry1ou	116	12	impaired	impaired	JJ
cord-344835-iivry1ou	116	13	immunity	immunity	NN
cord-344835-iivry1ou	116	14	,	,	,
cord-344835-iivry1ou	116	15	increased	increase	VBN
cord-344835-iivry1ou	116	16	susceptibility	susceptibility	NN
cord-344835-iivry1ou	116	17	to	to	IN
cord-344835-iivry1ou	116	18	viral	viral	JJ
cord-344835-iivry1ou	116	19	infections	infection	NNS
cord-344835-iivry1ou	116	20	and	and	CC
cord-344835-iivry1ou	116	21	increased	increase	VBN
cord-344835-iivry1ou	116	22	inflammation	inflammation	NN
cord-344835-iivry1ou	116	23	[	[	-LRB-
cord-344835-iivry1ou	116	24	75	75	CD
cord-344835-iivry1ou	116	25	]	]	-RRB-
cord-344835-iivry1ou	116	26	[	[	-LRB-
cord-344835-iivry1ou	116	27	76	76	CD
cord-344835-iivry1ou	116	28	]	]	-RRB-
cord-344835-iivry1ou	116	29	[	[	-LRB-
cord-344835-iivry1ou	116	30	77	77	CD
cord-344835-iivry1ou	116	31	]	]	-RRB-
cord-344835-iivry1ou	116	32	.	.	.
cord-344835-iivry1ou	117	1	Although	although	IN
cord-344835-iivry1ou	117	2	Saetta	Saetta	NNP
cord-344835-iivry1ou	117	3	et	et	NNP
cord-344835-iivry1ou	117	4	al	al	NNP
cord-344835-iivry1ou	117	5	also	also	RB
cord-344835-iivry1ou	117	6	found	find	VBD
cord-344835-iivry1ou	117	7	increased	increase	VBN
cord-344835-iivry1ou	117	8	T	T	NNP
cord-344835-iivry1ou	117	9	cell	cell	NN
cord-344835-iivry1ou	117	10	numbers	number	NNS
cord-344835-iivry1ou	117	11	in	in	IN
cord-344835-iivry1ou	117	12	endobronchial	endobronchial	JJ
cord-344835-iivry1ou	117	13	biopsies	biopsy	NNS
cord-344835-iivry1ou	117	14	from	from	IN
cord-344835-iivry1ou	117	15	chronic	chronic	JJ
cord-344835-iivry1ou	117	16	bronchitis	bronchitis	NN
cord-344835-iivry1ou	117	17	patients	patient	NNS
cord-344835-iivry1ou	117	18	on	on	IN
cord-344835-iivry1ou	117	19	mild	mild	JJ
cord-344835-iivry1ou	117	20	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	117	21	,	,	,
cord-344835-iivry1ou	117	22	no	no	DT
cord-344835-iivry1ou	117	23	difference	difference	NN
cord-344835-iivry1ou	117	24	was	be	VBD
cord-344835-iivry1ou	117	25	detected	detect	VBN
cord-344835-iivry1ou	117	26	in	in	IN
cord-344835-iivry1ou	117	27	CD4	CD4	NNP
cord-344835-iivry1ou	117	28	or	or	CC
cord-344835-iivry1ou	117	29	CD8+ve	CD8+ve	NNP
cord-344835-iivry1ou	117	30	cell	cell	NN
cord-344835-iivry1ou	117	31	numbers	number	NNS
cord-344835-iivry1ou	117	32	[	[	-LRB-
cord-344835-iivry1ou	117	33	45	45	CD
cord-344835-iivry1ou	117	34	]	]	-RRB-
cord-344835-iivry1ou	117	35	.	.	.
cord-344835-iivry1ou	118	1	This	this	DT
cord-344835-iivry1ou	118	2	discrepancy	discrepancy	NN
cord-344835-iivry1ou	118	3	may	may	MD
cord-344835-iivry1ou	118	4	be	be	VB
cord-344835-iivry1ou	118	5	attributed	attribute	VBN
cord-344835-iivry1ou	118	6	to	to	IN
cord-344835-iivry1ou	118	7	the	the	DT
cord-344835-iivry1ou	118	8	fact	fact	NN
cord-344835-iivry1ou	118	9	that	that	IN
cord-344835-iivry1ou	118	10	we	-PRON-	PRP
cord-344835-iivry1ou	118	11	examined	examine	VBD
cord-344835-iivry1ou	118	12	sputum	sputum	NN
cord-344835-iivry1ou	118	13	samples	sample	NNS
cord-344835-iivry1ou	118	14	(	(	-LRB-
cord-344835-iivry1ou	118	15	not	not	RB
cord-344835-iivry1ou	118	16	biopsies	biopsy	NNS
cord-344835-iivry1ou	118	17	)	)	-RRB-
cord-344835-iivry1ou	118	18	from	from	IN
cord-344835-iivry1ou	118	19	COPD	COPD	NNP
cord-344835-iivry1ou	118	20	patients	patient	NNS
cord-344835-iivry1ou	118	21	(	(	-LRB-
cord-344835-iivry1ou	118	22	not	not	RB
cord-344835-iivry1ou	118	23	chronic	chronic	JJ
cord-344835-iivry1ou	118	24	bronchitis	bronchitis	NN
cord-344835-iivry1ou	118	25	)	)	-RRB-
cord-344835-iivry1ou	118	26	on	on	IN
cord-344835-iivry1ou	118	27	severe	severe	JJ
cord-344835-iivry1ou	118	28	exacerbation	exacerbation	NN
cord-344835-iivry1ou	118	29	(	(	-LRB-
cord-344835-iivry1ou	118	30	not	not	RB
cord-344835-iivry1ou	118	31	mild	mild	JJ
cord-344835-iivry1ou	118	32	exacerbation	exacerbation	NN
cord-344835-iivry1ou	118	33	)	)	-RRB-
cord-344835-iivry1ou	118	34	.	.	.
cord-344835-iivry1ou	119	1	Moreover	moreover	RB
cord-344835-iivry1ou	119	2	,	,	,
cord-344835-iivry1ou	119	3	Saetta	Saetta	NNP
cord-344835-iivry1ou	119	4	et	et	NNP
cord-344835-iivry1ou	119	5	al	al	NNP
cord-344835-iivry1ou	119	6	compared	compare	VBD
cord-344835-iivry1ou	119	7	different	different	JJ
cord-344835-iivry1ou	119	8	patients	patient	NNS
cord-344835-iivry1ou	119	9	on	on	IN
cord-344835-iivry1ou	119	10	exacerbation	exacerbation	NN
cord-344835-iivry1ou	119	11	and	and	CC
cord-344835-iivry1ou	119	12	on	on	IN
cord-344835-iivry1ou	119	13	stable	stable	JJ
cord-344835-iivry1ou	119	14	state	state	NN
cord-344835-iivry1ou	119	15	,	,	,
cord-344835-iivry1ou	119	16	which	which	WDT
cord-344835-iivry1ou	119	17	could	could	MD
cord-344835-iivry1ou	119	18	be	be	VB
cord-344835-iivry1ou	119	19	a	a	DT
cord-344835-iivry1ou	119	20	limitation	limitation	NN
cord-344835-iivry1ou	119	21	in	in	IN
cord-344835-iivry1ou	119	22	their	-PRON-	PRP$
cord-344835-iivry1ou	119	23	study	study	NN
cord-344835-iivry1ou	119	24	.	.	.
cord-344835-iivry1ou	120	1	However	however	RB
cord-344835-iivry1ou	120	2	,	,	,
cord-344835-iivry1ou	120	3	finding	find	VBG
cord-344835-iivry1ou	120	4	increased	increase	VBD
cord-344835-iivry1ou	120	5	T	T	NNP
cord-344835-iivry1ou	120	6	cell	cell	NN
cord-344835-iivry1ou	120	7	numbers	number	NNS
cord-344835-iivry1ou	120	8	still	still	RB
cord-344835-iivry1ou	120	9	adds	add	VBZ
cord-344835-iivry1ou	120	10	evidence	evidence	NN
cord-344835-iivry1ou	120	11	to	to	IN
cord-344835-iivry1ou	120	12	the	the	DT
cord-344835-iivry1ou	120	13	argument	argument	NN
cord-344835-iivry1ou	120	14	that	that	IN
cord-344835-iivry1ou	120	15	immune	immune	JJ
cord-344835-iivry1ou	120	16	responses	response	NNS
cord-344835-iivry1ou	120	17	may	may	MD
cord-344835-iivry1ou	120	18	be	be	VB
cord-344835-iivry1ou	120	19	involved	involve	VBN
cord-344835-iivry1ou	120	20	in	in	IN
cord-344835-iivry1ou	120	21	the	the	DT
cord-344835-iivry1ou	120	22	mechanisms	mechanism	NNS
cord-344835-iivry1ou	120	23	of	of	IN
cord-344835-iivry1ou	120	24	increased	increase	VBN
cord-344835-iivry1ou	120	25	airway	airway	NN
cord-344835-iivry1ou	120	26	inflammation	inflammation	NN
cord-344835-iivry1ou	120	27	during	during	IN
cord-344835-iivry1ou	120	28	COPD	COPD	NNP
cord-344835-iivry1ou	120	29	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	120	30	.	.	.
cord-344835-iivry1ou	121	1	It	-PRON-	PRP
cord-344835-iivry1ou	121	2	would	would	MD
cord-344835-iivry1ou	121	3	be	be	VB
cord-344835-iivry1ou	121	4	logical	logical	JJ
cord-344835-iivry1ou	121	5	to	to	TO
cord-344835-iivry1ou	121	6	assume	assume	VB
cord-344835-iivry1ou	121	7	that	that	IN
cord-344835-iivry1ou	121	8	small	small	JJ
cord-344835-iivry1ou	121	9	increases	increase	NNS
cord-344835-iivry1ou	121	10	in	in	IN
cord-344835-iivry1ou	121	11	airway	airway	NN
cord-344835-iivry1ou	121	12	inflammation	inflammation	NN
cord-344835-iivry1ou	121	13	in	in	IN
cord-344835-iivry1ou	121	14	patients	patient	NNS
cord-344835-iivry1ou	121	15	with	with	IN
cord-344835-iivry1ou	121	16	already	already	RB
cord-344835-iivry1ou	121	17	increased	increase	VBN
cord-344835-iivry1ou	121	18	baseline	baseline	JJ
cord-344835-iivry1ou	121	19	levels	level	NNS
cord-344835-iivry1ou	121	20	of	of	IN
cord-344835-iivry1ou	121	21	inflammation	inflammation	NN
cord-344835-iivry1ou	121	22	can	can	MD
cord-344835-iivry1ou	121	23	easily	easily	RB
cord-344835-iivry1ou	121	24	trigger	trigger	VB
cord-344835-iivry1ou	121	25	a	a	DT
cord-344835-iivry1ou	121	26	COPD	COPD	NNP
cord-344835-iivry1ou	121	27	exacerbation	exacerbation	NN
cord-344835-iivry1ou	121	28	.	.	.
cord-344835-iivry1ou	122	1	This	this	DT
cord-344835-iivry1ou	122	2	presumes	presume	VBZ
cord-344835-iivry1ou	122	3	the	the	DT
cord-344835-iivry1ou	122	4	existence	existence	NN
cord-344835-iivry1ou	122	5	of	of	IN
cord-344835-iivry1ou	122	6	an	an	DT
cord-344835-iivry1ou	122	7	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	122	8	threshold	threshold	NN
cord-344835-iivry1ou	122	9	,	,	,
cord-344835-iivry1ou	122	10	above	above	IN
cord-344835-iivry1ou	122	11	which	which	WDT
cord-344835-iivry1ou	122	12	exacerbation	exacerbation	NN
cord-344835-iivry1ou	122	13	occurs	occur	VBZ
cord-344835-iivry1ou	122	14	.	.	.
cord-344835-iivry1ou	123	1	In	in	IN
cord-344835-iivry1ou	123	2	relation	relation	NN
cord-344835-iivry1ou	123	3	to	to	IN
cord-344835-iivry1ou	123	4	this	this	DT
cord-344835-iivry1ou	123	5	hypothesis	hypothesis	NN
cord-344835-iivry1ou	123	6	,	,	,
cord-344835-iivry1ou	123	7	Bhowmik	Bhowmik	NNP
cord-344835-iivry1ou	123	8	et	et	NNP
cord-344835-iivry1ou	123	9	al	al	NNP
cord-344835-iivry1ou	123	10	showed	show	VBD
cord-344835-iivry1ou	123	11	that	that	IN
cord-344835-iivry1ou	123	12	COPD	COPD	NNP
cord-344835-iivry1ou	123	13	patients	patient	NNS
cord-344835-iivry1ou	123	14	with	with	IN
cord-344835-iivry1ou	123	15	frequent	frequent	JJ
cord-344835-iivry1ou	123	16	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	123	17	(	(	-LRB-
cord-344835-iivry1ou	123	18	≥	≥	CD
cord-344835-iivry1ou	123	19	3	3	CD
cord-344835-iivry1ou	123	20	episodes/	episodes/	NN
cord-344835-iivry1ou	123	21	year	year	NN
cord-344835-iivry1ou	123	22	)	)	-RRB-
cord-344835-iivry1ou	123	23	have	have	VBP
cord-344835-iivry1ou	123	24	increased	increase	VBN
cord-344835-iivry1ou	123	25	baseline	baseline	JJ
cord-344835-iivry1ou	123	26	sputum	sputum	NN
cord-344835-iivry1ou	123	27	IL-6	IL-6	NNP
cord-344835-iivry1ou	123	28	and	and	CC
cord-344835-iivry1ou	123	29	IL-8	IL-8	NNP
cord-344835-iivry1ou	123	30	levels	level	NNS
cord-344835-iivry1ou	123	31	[	[	-LRB-
cord-344835-iivry1ou	123	32	78	78	CD
cord-344835-iivry1ou	123	33	]	]	-RRB-
cord-344835-iivry1ou	123	34	.	.	.
cord-344835-iivry1ou	124	1	However	however	RB
cord-344835-iivry1ou	124	2	,	,	,
cord-344835-iivry1ou	124	3	it	-PRON-	PRP
cord-344835-iivry1ou	124	4	was	be	VBD
cord-344835-iivry1ou	124	5	not	not	RB
cord-344835-iivry1ou	124	6	examined	examine	VBN
cord-344835-iivry1ou	124	7	whether	whether	IN
cord-344835-iivry1ou	124	8	this	this	DT
cord-344835-iivry1ou	124	9	was	be	VBD
cord-344835-iivry1ou	124	10	related	relate	VBN
cord-344835-iivry1ou	124	11	to	to	IN
cord-344835-iivry1ou	124	12	bacterial	bacterial	JJ
cord-344835-iivry1ou	124	13	colonization	colonization	NN
cord-344835-iivry1ou	124	14	,	,	,
cord-344835-iivry1ou	124	15	as	as	IN
cord-344835-iivry1ou	124	16	bacterial	bacterial	JJ
cord-344835-iivry1ou	124	17	colonization	colonization	NN
cord-344835-iivry1ou	124	18	can	can	MD
cord-344835-iivry1ou	124	19	increase	increase	VB
cord-344835-iivry1ou	124	20	airway	airway	JJ
cord-344835-iivry1ou	124	21	inflammation	inflammation	NN
cord-344835-iivry1ou	124	22	and	and	CC
cord-344835-iivry1ou	124	23	exacerbation	exacerbation	NN
cord-344835-iivry1ou	124	24	rates	rate	NNS
cord-344835-iivry1ou	124	25	.	.	.
cord-344835-iivry1ou	125	1	The	the	DT
cord-344835-iivry1ou	125	2	same	same	JJ
cord-344835-iivry1ou	125	3	group	group	NN
cord-344835-iivry1ou	125	4	also	also	RB
cord-344835-iivry1ou	125	5	showed	show	VBD
cord-344835-iivry1ou	125	6	faster	fast	JJR
cord-344835-iivry1ou	125	7	rises	rise	NNS
cord-344835-iivry1ou	125	8	over	over	IN
cord-344835-iivry1ou	125	9	time	time	NN
cord-344835-iivry1ou	125	10	in	in	IN
cord-344835-iivry1ou	125	11	plasma	plasma	NN
cord-344835-iivry1ou	125	12	fibrinogen	fibrinogen	NN
cord-344835-iivry1ou	125	13	and	and	CC
cord-344835-iivry1ou	125	14	sputum	sputum	NN
cord-344835-iivry1ou	125	15	IL-6	IL-6	NNP
cord-344835-iivry1ou	125	16	in	in	IN
cord-344835-iivry1ou	125	17	patients	patient	NNS
cord-344835-iivry1ou	125	18	with	with	IN
cord-344835-iivry1ou	125	19	frequent	frequent	JJ
cord-344835-iivry1ou	125	20	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	125	21	[	[	-LRB-
cord-344835-iivry1ou	125	22	79	79	CD
cord-344835-iivry1ou	125	23	]	]	-RRB-
cord-344835-iivry1ou	125	24	.	.	.
cord-344835-iivry1ou	126	1	On	on	IN
cord-344835-iivry1ou	126	2	the	the	DT
cord-344835-iivry1ou	126	3	contrary	contrary	NN
cord-344835-iivry1ou	126	4	,	,	,
cord-344835-iivry1ou	126	5	Gombertz	Gombertz	NNP
cord-344835-iivry1ou	126	6	et	et	NNP
cord-344835-iivry1ou	126	7	al	al	NNP
cord-344835-iivry1ou	126	8	did	do	VBD
cord-344835-iivry1ou	126	9	not	not	RB
cord-344835-iivry1ou	126	10	detect	detect	VB
cord-344835-iivry1ou	126	11	any	any	DT
cord-344835-iivry1ou	126	12	difference	difference	NN
cord-344835-iivry1ou	126	13	in	in	IN
cord-344835-iivry1ou	126	14	neutrophilic	neutrophilic	JJ
cord-344835-iivry1ou	126	15	mediators	mediator	NNS
cord-344835-iivry1ou	126	16	(	(	-LRB-
cord-344835-iivry1ou	126	17	including	include	VBG
cord-344835-iivry1ou	126	18	IL-8	IL-8	NNP
cord-344835-iivry1ou	126	19	)	)	-RRB-
cord-344835-iivry1ou	126	20	between	between	IN
cord-344835-iivry1ou	126	21	frequent	frequent	JJ
cord-344835-iivry1ou	126	22	(	(	-LRB-
cord-344835-iivry1ou	126	23	≥	≥	CD
cord-344835-iivry1ou	126	24	3	3	CD
cord-344835-iivry1ou	126	25	episodes	episode	NNS
cord-344835-iivry1ou	126	26	/	/	SYM
cord-344835-iivry1ou	126	27	year	year	NN
cord-344835-iivry1ou	126	28	)	)	-RRB-
cord-344835-iivry1ou	126	29	and	and	CC
cord-344835-iivry1ou	126	30	infrequent	infrequent	JJ
cord-344835-iivry1ou	126	31	exacerbators	exacerbator	NNS
cord-344835-iivry1ou	126	32	[	[	-LRB-
cord-344835-iivry1ou	126	33	80	80	CD
cord-344835-iivry1ou	126	34	]	]	-RRB-
cord-344835-iivry1ou	126	35	.	.	.
cord-344835-iivry1ou	127	1	Interestingly	interestingly	RB
cord-344835-iivry1ou	127	2	,	,	,
cord-344835-iivry1ou	127	3	when	when	WRB
cord-344835-iivry1ou	127	4	patients	patient	NNS
cord-344835-iivry1ou	127	5	with	with	IN
cord-344835-iivry1ou	127	6	bronchiectasis	bronchiectasi	NNS
cord-344835-iivry1ou	127	7	were	be	VBD
cord-344835-iivry1ou	127	8	excluded	exclude	VBN
cord-344835-iivry1ou	127	9	from	from	IN
cord-344835-iivry1ou	127	10	the	the	DT
cord-344835-iivry1ou	127	11	analysis	analysis	NN
cord-344835-iivry1ou	127	12	,	,	,
cord-344835-iivry1ou	127	13	SLPI	SLPI	NNP
cord-344835-iivry1ou	127	14	was	be	VBD
cord-344835-iivry1ou	127	15	found	find	VBN
cord-344835-iivry1ou	127	16	to	to	TO
cord-344835-iivry1ou	127	17	be	be	VB
cord-344835-iivry1ou	127	18	lower	low	JJR
cord-344835-iivry1ou	127	19	in	in	IN
cord-344835-iivry1ou	127	20	COPD	COPD	NNP
cord-344835-iivry1ou	127	21	patients	patient	NNS
cord-344835-iivry1ou	127	22	with	with	IN
cord-344835-iivry1ou	127	23	frequent	frequent	JJ
cord-344835-iivry1ou	127	24	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	127	25	,	,	,
cord-344835-iivry1ou	127	26	which	which	WDT
cord-344835-iivry1ou	127	27	suggests	suggest	VBZ
cord-344835-iivry1ou	127	28	that	that	IN
cord-344835-iivry1ou	127	29	COPD	COPD	NNP
cord-344835-iivry1ou	127	30	patients	patient	NNS
cord-344835-iivry1ou	127	31	with	with	IN
cord-344835-iivry1ou	127	32	bronchiectasis	bronchiectasis	NN
cord-344835-iivry1ou	127	33	may	may	MD
cord-344835-iivry1ou	127	34	represent	represent	VB
cord-344835-iivry1ou	127	35	a	a	DT
cord-344835-iivry1ou	127	36	distinct	distinct	JJ
cord-344835-iivry1ou	127	37	group	group	NN
cord-344835-iivry1ou	127	38	.	.	.
cord-344835-iivry1ou	128	1	Fujimoto	Fujimoto	NNP
cord-344835-iivry1ou	128	2	et	et	NNP
cord-344835-iivry1ou	128	3	al	al	NNP
cord-344835-iivry1ou	128	4	also	also	RB
cord-344835-iivry1ou	128	5	report	report	VBP
cord-344835-iivry1ou	128	6	no	no	DT
cord-344835-iivry1ou	128	7	difference	difference	NN
cord-344835-iivry1ou	128	8	in	in	IN
cord-344835-iivry1ou	128	9	baseline	baseline	NN
cord-344835-iivry1ou	129	1	IL-8	IL-8	NNP
cord-344835-iivry1ou	129	2	and	and	CC
cord-344835-iivry1ou	129	3	markers	marker	NNS
cord-344835-iivry1ou	129	4	of	of	IN
cord-344835-iivry1ou	129	5	eosinophilic	eosinophilic	JJ
cord-344835-iivry1ou	129	6	inflammation	inflammation	NN
cord-344835-iivry1ou	129	7	between	between	IN
cord-344835-iivry1ou	129	8	stable	stable	JJ
cord-344835-iivry1ou	129	9	and	and	CC
cord-344835-iivry1ou	129	10	unstable	unstable	JJ
cord-344835-iivry1ou	129	11	COPD	COPD	NNP
cord-344835-iivry1ou	129	12	patients	patient	NNS
cord-344835-iivry1ou	129	13	[	[	-LRB-
cord-344835-iivry1ou	129	14	42	42	CD
cord-344835-iivry1ou	129	15	]	]	-RRB-
cord-344835-iivry1ou	129	16	.	.	.
cord-344835-iivry1ou	130	1	However	however	RB
cord-344835-iivry1ou	130	2	,	,	,
cord-344835-iivry1ou	130	3	results	result	NNS
cord-344835-iivry1ou	130	4	between	between	IN
cord-344835-iivry1ou	130	5	this	this	DT
cord-344835-iivry1ou	130	6	and	and	CC
cord-344835-iivry1ou	130	7	other	other	JJ
cord-344835-iivry1ou	130	8	studies	study	NNS
cord-344835-iivry1ou	130	9	are	be	VBP
cord-344835-iivry1ou	130	10	not	not	RB
cord-344835-iivry1ou	130	11	comparable	comparable	JJ
cord-344835-iivry1ou	130	12	due	due	IN
cord-344835-iivry1ou	130	13	to	to	IN
cord-344835-iivry1ou	130	14	lower	low	JJR
cord-344835-iivry1ou	130	15	exacerbation	exacerbation	NN
cord-344835-iivry1ou	130	16	rates	rate	NNS
cord-344835-iivry1ou	130	17	(	(	-LRB-
cord-344835-iivry1ou	130	18	mean	mean	VBP
cord-344835-iivry1ou	130	19	1	1	CD
cord-344835-iivry1ou	130	20	episode	episode	NN
cord-344835-iivry1ou	130	21	/	/	SYM
cord-344835-iivry1ou	130	22	year	year	NN
cord-344835-iivry1ou	130	23	)	)	-RRB-
cord-344835-iivry1ou	130	24	in	in	IN
cord-344835-iivry1ou	130	25	the	the	DT
cord-344835-iivry1ou	130	26	unstable	unstable	JJ
cord-344835-iivry1ou	130	27	COPD	COPD	NNP
cord-344835-iivry1ou	130	28	group	group	NN
cord-344835-iivry1ou	130	29	in	in	IN
cord-344835-iivry1ou	130	30	this	this	DT
cord-344835-iivry1ou	130	31	study	study	NN
cord-344835-iivry1ou	130	32	.	.	.
cord-344835-iivry1ou	131	1	In	in	IN
cord-344835-iivry1ou	131	2	conclusion	conclusion	NN
cord-344835-iivry1ou	131	3	,	,	,
cord-344835-iivry1ou	131	4	data	datum	NNS
cord-344835-iivry1ou	131	5	relating	relate	VBG
cord-344835-iivry1ou	131	6	baseline	baseline	JJ
cord-344835-iivry1ou	131	7	airway	airway	NN
cord-344835-iivry1ou	131	8	inflammation	inflammation	NN
cord-344835-iivry1ou	131	9	to	to	IN
cord-344835-iivry1ou	131	10	exacerbation	exacerbation	NN
cord-344835-iivry1ou	131	11	frequency	frequency	NN
cord-344835-iivry1ou	131	12	are	be	VBP
cord-344835-iivry1ou	131	13	rather	rather	RB
cord-344835-iivry1ou	131	14	controversial	controversial	JJ
cord-344835-iivry1ou	131	15	.	.	.
cord-344835-iivry1ou	132	1	Part	part	NN
cord-344835-iivry1ou	132	2	of	of	IN
cord-344835-iivry1ou	132	3	the	the	DT
cord-344835-iivry1ou	132	4	existing	exist	VBG
cord-344835-iivry1ou	132	5	confusion	confusion	NN
cord-344835-iivry1ou	132	6	may	may	MD
cord-344835-iivry1ou	132	7	be	be	VB
cord-344835-iivry1ou	132	8	due	due	JJ
cord-344835-iivry1ou	132	9	to	to	IN
cord-344835-iivry1ou	132	10	significant	significant	JJ
cord-344835-iivry1ou	132	11	heterogeneity	heterogeneity	NN
cord-344835-iivry1ou	132	12	among	among	IN
cord-344835-iivry1ou	132	13	COPD	COPD	NNP
cord-344835-iivry1ou	132	14	patients	patient	NNS
cord-344835-iivry1ou	132	15	and	and	CC
cord-344835-iivry1ou	132	16	to	to	IN
cord-344835-iivry1ou	132	17	the	the	DT
cord-344835-iivry1ou	132	18	existence	existence	NN
cord-344835-iivry1ou	132	19	of	of	IN
cord-344835-iivry1ou	132	20	several	several	JJ
cord-344835-iivry1ou	132	21	factors	factor	NNS
cord-344835-iivry1ou	132	22	,	,	,
cord-344835-iivry1ou	132	23	like	like	IN
cord-344835-iivry1ou	132	24	bacterial	bacterial	JJ
cord-344835-iivry1ou	132	25	colonization	colonization	NN
cord-344835-iivry1ou	132	26	and	and	CC
cord-344835-iivry1ou	132	27	bronchiectasis	bronchiectasis	NN
cord-344835-iivry1ou	132	28	that	that	WDT
cord-344835-iivry1ou	132	29	may	may	MD
cord-344835-iivry1ou	132	30	increase	increase	VB
cord-344835-iivry1ou	132	31	airway	airway	NN
cord-344835-iivry1ou	132	32	inflammation	inflammation	NN
cord-344835-iivry1ou	132	33	.	.	.
cord-344835-iivry1ou	133	1	In	in	IN
cord-344835-iivry1ou	133	2	particular	particular	JJ
cord-344835-iivry1ou	133	3	,	,	,
cord-344835-iivry1ou	133	4	COPD	COPD	NNP
cord-344835-iivry1ou	133	5	patients	patient	NNS
cord-344835-iivry1ou	133	6	with	with	IN
cord-344835-iivry1ou	133	7	bronchiectasis	bronchiectasis	NN
cord-344835-iivry1ou	133	8	may	may	MD
cord-344835-iivry1ou	133	9	represent	represent	VB
cord-344835-iivry1ou	133	10	a	a	DT
cord-344835-iivry1ou	133	11	distinct	distinct	JJ
cord-344835-iivry1ou	133	12	group	group	NN
cord-344835-iivry1ou	133	13	characterized	characterize	VBN
cord-344835-iivry1ou	133	14	by	by	IN
cord-344835-iivry1ou	133	15	higher	high	JJR
cord-344835-iivry1ou	133	16	rates	rate	NNS
cord-344835-iivry1ou	133	17	of	of	IN
cord-344835-iivry1ou	133	18	bacterial	bacterial	JJ
cord-344835-iivry1ou	133	19	colonization	colonization	NN
cord-344835-iivry1ou	133	20	,	,	,
cord-344835-iivry1ou	133	21	increased	increase	VBN
cord-344835-iivry1ou	133	22	baseline	baseline	JJ
cord-344835-iivry1ou	133	23	levels	level	NNS
cord-344835-iivry1ou	133	24	of	of	IN
cord-344835-iivry1ou	133	25	airway	airway	NN
cord-344835-iivry1ou	133	26	inflammation	inflammation	NN
cord-344835-iivry1ou	133	27	and	and	CC
cord-344835-iivry1ou	133	28	longer	long	JJR
cord-344835-iivry1ou	133	29	symptom	symptom	NN
cord-344835-iivry1ou	133	30	recovery	recovery	NN
cord-344835-iivry1ou	133	31	times	time	NNS
cord-344835-iivry1ou	133	32	at	at	IN
cord-344835-iivry1ou	133	33	exacerbation	exacerbation	NN
cord-344835-iivry1ou	133	34	[	[	-LRB-
cord-344835-iivry1ou	133	35	81	81	CD
cord-344835-iivry1ou	133	36	]	]	-RRB-
cord-344835-iivry1ou	133	37	.	.	.
cord-344835-iivry1ou	134	1	Episodes	episode	NNS
cord-344835-iivry1ou	134	2	of	of	IN
cord-344835-iivry1ou	134	3	COPD	COPD	NNP
cord-344835-iivry1ou	134	4	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	134	5	are	be	VBP
cord-344835-iivry1ou	134	6	characterized	characterize	VBN
cord-344835-iivry1ou	134	7	by	by	IN
cord-344835-iivry1ou	134	8	an	an	DT
cord-344835-iivry1ou	134	9	acute	acute	JJ
cord-344835-iivry1ou	134	10	increase	increase	NN
cord-344835-iivry1ou	134	11	in	in	IN
cord-344835-iivry1ou	134	12	a	a	DT
cord-344835-iivry1ou	134	13	patient	patient	NN
cord-344835-iivry1ou	134	14	's	's	POS
cord-344835-iivry1ou	134	15	baseline	baseline	JJ
cord-344835-iivry1ou	134	16	dyspnoea	dyspnoea	NNS
cord-344835-iivry1ou	134	17	,	,	,
cord-344835-iivry1ou	134	18	cough	cough	NN
cord-344835-iivry1ou	134	19	and/or	and/or	CC
cord-344835-iivry1ou	134	20	sputum	sputum	NN
cord-344835-iivry1ou	134	21	production	production	NN
cord-344835-iivry1ou	134	22	[	[	-LRB-
cord-344835-iivry1ou	134	23	8	8	CD
cord-344835-iivry1ou	134	24	]	]	-RRB-
cord-344835-iivry1ou	134	25	.	.	.
cord-344835-iivry1ou	135	1	Severe	severe	JJ
cord-344835-iivry1ou	135	2	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	135	3	are	be	VBP
cord-344835-iivry1ou	135	4	also	also	RB
cord-344835-iivry1ou	135	5	associated	associate	VBN
cord-344835-iivry1ou	135	6	with	with	IN
cord-344835-iivry1ou	135	7	worsening	worsen	VBG
cord-344835-iivry1ou	135	8	of	of	IN
cord-344835-iivry1ou	135	9	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	135	10	gas	gas	NN
cord-344835-iivry1ou	135	11	exchange	exchange	NN
cord-344835-iivry1ou	135	12	that	that	WDT
cord-344835-iivry1ou	135	13	may	may	MD
cord-344835-iivry1ou	135	14	lead	lead	VB
cord-344835-iivry1ou	135	15	to	to	IN
cord-344835-iivry1ou	135	16	hypoxemia	hypoxemia	NN
cord-344835-iivry1ou	135	17	with	with	IN
cord-344835-iivry1ou	135	18	or	or	CC
cord-344835-iivry1ou	135	19	without	without	IN
cord-344835-iivry1ou	135	20	hypercapnia	hypercapnia	NN
cord-344835-iivry1ou	135	21	[	[	-LRB-
cord-344835-iivry1ou	135	22	82	82	CD
cord-344835-iivry1ou	135	23	]	]	-RRB-
cord-344835-iivry1ou	135	24	.	.	.
cord-344835-iivry1ou	136	1	In	in	IN
cord-344835-iivry1ou	136	2	order	order	NN
cord-344835-iivry1ou	136	3	to	to	TO
cord-344835-iivry1ou	136	4	support	support	VB
cord-344835-iivry1ou	136	5	a	a	DT
cord-344835-iivry1ou	136	6	role	role	NN
cord-344835-iivry1ou	136	7	for	for	IN
cord-344835-iivry1ou	136	8	airway	airway	NN
cord-344835-iivry1ou	136	9	inflammation	inflammation	NN
cord-344835-iivry1ou	136	10	in	in	IN
cord-344835-iivry1ou	136	11	COPD	COPD	NNP
cord-344835-iivry1ou	136	12	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	137	1	the	the	DT
cord-344835-iivry1ou	137	2	mechanisms	mechanism	NNS
cord-344835-iivry1ou	137	3	which	which	WDT
cord-344835-iivry1ou	137	4	are	be	VBP
cord-344835-iivry1ou	137	5	induced	induce	VBN
cord-344835-iivry1ou	137	6	by	by	IN
cord-344835-iivry1ou	137	7	airway	airway	NN
cord-344835-iivry1ou	137	8	inflammation	inflammation	NN
cord-344835-iivry1ou	137	9	need	need	VBP
cord-344835-iivry1ou	137	10	to	to	TO
cord-344835-iivry1ou	137	11	be	be	VB
cord-344835-iivry1ou	137	12	related	relate	VBN
cord-344835-iivry1ou	137	13	to	to	IN
cord-344835-iivry1ou	137	14	the	the	DT
cord-344835-iivry1ou	137	15	symptoms	symptom	NNS
cord-344835-iivry1ou	137	16	and	and	CC
cord-344835-iivry1ou	137	17	pathophysiology	pathophysiology	NN
cord-344835-iivry1ou	137	18	of	of	IN
cord-344835-iivry1ou	137	19	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	137	20	.	.	.
cord-344835-iivry1ou	138	1	Increased	increase	VBN
cord-344835-iivry1ou	138	2	airway	airway	NN
cord-344835-iivry1ou	138	3	inflammation	inflammation	NN
cord-344835-iivry1ou	138	4	induces	induce	VBZ
cord-344835-iivry1ou	138	5	many	many	JJ
cord-344835-iivry1ou	138	6	pathologic	pathologic	JJ
cord-344835-iivry1ou	138	7	changes	change	NNS
cord-344835-iivry1ou	138	8	on	on	IN
cord-344835-iivry1ou	138	9	the	the	DT
cord-344835-iivry1ou	138	10	airways	airway	NNS
cord-344835-iivry1ou	138	11	.	.	.
cord-344835-iivry1ou	139	1	Accumulation	accumulation	NN
cord-344835-iivry1ou	139	2	of	of	IN
cord-344835-iivry1ou	139	3	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	139	4	cells	cell	NNS
cord-344835-iivry1ou	139	5	in	in	IN
cord-344835-iivry1ou	139	6	the	the	DT
cord-344835-iivry1ou	139	7	airway	airway	NN
cord-344835-iivry1ou	139	8	mucosa	mucosa	NN
cord-344835-iivry1ou	139	9	by	by	IN
cord-344835-iivry1ou	139	10	itself	-PRON-	PRP
cord-344835-iivry1ou	139	11	causes	cause	VBZ
cord-344835-iivry1ou	139	12	airway	airway	NN
cord-344835-iivry1ou	139	13	wall	wall	NN
cord-344835-iivry1ou	139	14	thickening	thickening	NN
cord-344835-iivry1ou	139	15	.	.	.
cord-344835-iivry1ou	140	1	Inflammatory	inflammatory	JJ
cord-344835-iivry1ou	140	2	cells	cell	NNS
cord-344835-iivry1ou	140	3	can	can	MD
cord-344835-iivry1ou	140	4	release	release	VB
cord-344835-iivry1ou	140	5	potentially	potentially	RB
cord-344835-iivry1ou	140	6	harmful	harmful	JJ
cord-344835-iivry1ou	140	7	mediators	mediator	NNS
cord-344835-iivry1ou	140	8	,	,	,
cord-344835-iivry1ou	140	9	such	such	JJ
cord-344835-iivry1ou	140	10	as	as	IN
cord-344835-iivry1ou	140	11	proteases	protease	NNS
cord-344835-iivry1ou	140	12	and	and	CC
cord-344835-iivry1ou	140	13	reactive	reactive	JJ
cord-344835-iivry1ou	140	14	oxygen	oxygen	NN
cord-344835-iivry1ou	140	15	species	specie	NNS
cord-344835-iivry1ou	140	16	[	[	-LRB-
cord-344835-iivry1ou	140	17	83	83	CD
cord-344835-iivry1ou	140	18	]	]	-RRB-
cord-344835-iivry1ou	140	19	.	.	.
cord-344835-iivry1ou	141	1	Neutrophil	Neutrophil	NNP
cord-344835-iivry1ou	141	2	and	and	CC
cord-344835-iivry1ou	141	3	eosinophil	eosinophil	JJ
cord-344835-iivry1ou	141	4	products	product	NNS
cord-344835-iivry1ou	141	5	,	,	,
cord-344835-iivry1ou	141	6	like	like	IN
cord-344835-iivry1ou	141	7	MPO	MPO	NNP
cord-344835-iivry1ou	141	8	,	,	,
cord-344835-iivry1ou	141	9	NE	NE	NNP
cord-344835-iivry1ou	141	10	and	and	CC
cord-344835-iivry1ou	141	11	eosinophilic	eosinophilic	JJ
cord-344835-iivry1ou	141	12	cationic	cationic	JJ
cord-344835-iivry1ou	141	13	protein	protein	NN
cord-344835-iivry1ou	141	14	(	(	-LRB-
cord-344835-iivry1ou	141	15	ECP	ECP	NNP
cord-344835-iivry1ou	141	16	)	)	-RRB-
cord-344835-iivry1ou	141	17	,	,	,
cord-344835-iivry1ou	141	18	have	have	VBP
cord-344835-iivry1ou	141	19	been	be	VBN
cord-344835-iivry1ou	141	20	found	find	VBN
cord-344835-iivry1ou	141	21	increased	increase	VBN
cord-344835-iivry1ou	141	22	on	on	IN
cord-344835-iivry1ou	141	23	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	141	24	,	,	,
cord-344835-iivry1ou	141	25	and	and	CC
cord-344835-iivry1ou	141	26	can	can	MD
cord-344835-iivry1ou	141	27	cause	cause	VB
cord-344835-iivry1ou	141	28	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	141	29	damage	damage	NN
cord-344835-iivry1ou	141	30	and	and	CC
cord-344835-iivry1ou	141	31	increased	increase	VBN
cord-344835-iivry1ou	141	32	permeability	permeability	NN
cord-344835-iivry1ou	141	33	of	of	IN
cord-344835-iivry1ou	141	34	the	the	DT
cord-344835-iivry1ou	141	35	bronchial	bronchial	JJ
cord-344835-iivry1ou	141	36	mucosa	mucosa	NN
cord-344835-iivry1ou	141	37	,	,	,
cord-344835-iivry1ou	141	38	resulting	result	VBG
cord-344835-iivry1ou	141	39	in	in	IN
cord-344835-iivry1ou	141	40	airway	airway	NN
cord-344835-iivry1ou	141	41	oedema	oedema	NN
cord-344835-iivry1ou	141	42	and	and	CC
cord-344835-iivry1ou	141	43	protein	protein	NN
cord-344835-iivry1ou	141	44	exudation	exudation	NN
cord-344835-iivry1ou	141	45	[	[	-LRB-
cord-344835-iivry1ou	141	46	20	20	CD
cord-344835-iivry1ou	141	47	,	,	,
cord-344835-iivry1ou	141	48	42	42	CD
cord-344835-iivry1ou	141	49	,	,	,
cord-344835-iivry1ou	141	50	62	62	CD
cord-344835-iivry1ou	141	51	,	,	,
cord-344835-iivry1ou	141	52	84	84	CD
cord-344835-iivry1ou	141	53	]	]	-RRB-
cord-344835-iivry1ou	141	54	.	.	.
cord-344835-iivry1ou	142	1	Inflammatory	inflammatory	JJ
cord-344835-iivry1ou	142	2	mediators	mediator	NNS
cord-344835-iivry1ou	142	3	,	,	,
cord-344835-iivry1ou	142	4	like	like	IN
cord-344835-iivry1ou	142	5	ECP	ECP	NNP
cord-344835-iivry1ou	142	6	,	,	,
cord-344835-iivry1ou	142	7	can	can	MD
cord-344835-iivry1ou	142	8	also	also	RB
cord-344835-iivry1ou	142	9	induce	induce	VB
cord-344835-iivry1ou	142	10	bronchoconstriction	bronchoconstriction	NN
cord-344835-iivry1ou	142	11	by	by	IN
cord-344835-iivry1ou	142	12	increasing	increase	VBG
cord-344835-iivry1ou	142	13	achetinocholine	achetinocholine	NN
cord-344835-iivry1ou	142	14	release	release	NN
cord-344835-iivry1ou	142	15	from	from	IN
cord-344835-iivry1ou	142	16	parasynmpathetic	parasynmpathetic	JJ
cord-344835-iivry1ou	142	17	nerves	nerve	NNS
cord-344835-iivry1ou	142	18	,	,	,
cord-344835-iivry1ou	142	19	while	while	IN
cord-344835-iivry1ou	142	20	others	other	NNS
cord-344835-iivry1ou	142	21	,	,	,
cord-344835-iivry1ou	142	22	like	like	IN
cord-344835-iivry1ou	142	23	NE	NE	NNP
cord-344835-iivry1ou	142	24	,	,	,
cord-344835-iivry1ou	142	25	increase	increase	VB
cord-344835-iivry1ou	142	26	mucus	mucus	NN
cord-344835-iivry1ou	142	27	secretion	secretion	NN
cord-344835-iivry1ou	142	28	[	[	-LRB-
cord-344835-iivry1ou	142	29	85	85	CD
cord-344835-iivry1ou	142	30	,	,	,
cord-344835-iivry1ou	142	31	86	86	CD
cord-344835-iivry1ou	142	32	]	]	-RRB-
cord-344835-iivry1ou	142	33	.	.	.
cord-344835-iivry1ou	143	1	Furthermore	furthermore	RB
cord-344835-iivry1ou	143	2	,	,	,
cord-344835-iivry1ou	143	3	mediators	mediator	NNS
cord-344835-iivry1ou	143	4	of	of	IN
cord-344835-iivry1ou	143	5	inflammation	inflammation	NN
cord-344835-iivry1ou	143	6	enhance	enhance	VBP
cord-344835-iivry1ou	143	7	coughing	cough	VBG
cord-344835-iivry1ou	143	8	[	[	-LRB-
cord-344835-iivry1ou	143	9	87	87	CD
cord-344835-iivry1ou	143	10	]	]	-RRB-
cord-344835-iivry1ou	143	11	.	.	.
cord-344835-iivry1ou	144	1	Potentially	potentially	RB
cord-344835-iivry1ou	144	2	harmful	harmful	JJ
cord-344835-iivry1ou	144	3	mediators	mediator	NNS
cord-344835-iivry1ou	144	4	may	may	MD
cord-344835-iivry1ou	144	5	be	be	VB
cord-344835-iivry1ou	144	6	released	release	VBN
cord-344835-iivry1ou	144	7	not	not	RB
cord-344835-iivry1ou	144	8	only	only	RB
cord-344835-iivry1ou	144	9	by	by	IN
cord-344835-iivry1ou	144	10	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	144	11	cells	cell	NNS
cord-344835-iivry1ou	144	12	but	but	CC
cord-344835-iivry1ou	144	13	also	also	RB
cord-344835-iivry1ou	144	14	by	by	IN
cord-344835-iivry1ou	144	15	resident	resident	JJ
cord-344835-iivry1ou	144	16	cells	cell	NNS
cord-344835-iivry1ou	144	17	.	.	.
cord-344835-iivry1ou	145	1	For	for	IN
cord-344835-iivry1ou	145	2	example	example	NN
cord-344835-iivry1ou	145	3	,	,	,
cord-344835-iivry1ou	145	4	endothelin	endothelin	NNP
cord-344835-iivry1ou	145	5	(	(	-LRB-
cord-344835-iivry1ou	145	6	ET)-1	ET)-1	NNP
cord-344835-iivry1ou	145	7	,	,	,
cord-344835-iivry1ou	145	8	which	which	WDT
cord-344835-iivry1ou	145	9	has	have	VBZ
cord-344835-iivry1ou	145	10	been	be	VBN
cord-344835-iivry1ou	145	11	found	find	VBN
cord-344835-iivry1ou	145	12	increased	increase	VBN
cord-344835-iivry1ou	145	13	on	on	IN
cord-344835-iivry1ou	145	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	145	15	,	,	,
cord-344835-iivry1ou	145	16	can	can	MD
cord-344835-iivry1ou	145	17	be	be	VB
cord-344835-iivry1ou	145	18	released	release	VBN
cord-344835-iivry1ou	145	19	by	by	IN
cord-344835-iivry1ou	145	20	epithelial	epithelial	JJ
cord-344835-iivry1ou	145	21	cells	cell	NNS
cord-344835-iivry1ou	145	22	and	and	CC
cord-344835-iivry1ou	145	23	stimulates	stimulate	VBZ
cord-344835-iivry1ou	145	24	mucus	mucus	NN
cord-344835-iivry1ou	145	25	secretion	secretion	NN
cord-344835-iivry1ou	145	26	and	and	CC
cord-344835-iivry1ou	145	27	bronchial	bronchial	JJ
cord-344835-iivry1ou	145	28	hyperesponsiveness	hyperesponsiveness	NN
cord-344835-iivry1ou	145	29	[	[	-LRB-
cord-344835-iivry1ou	145	30	50	50	CD
cord-344835-iivry1ou	145	31	]	]	-RRB-
cord-344835-iivry1ou	145	32	.	.	.
cord-344835-iivry1ou	146	1	The	the	DT
cord-344835-iivry1ou	146	2	cascade	cascade	NN
cord-344835-iivry1ou	146	3	of	of	IN
cord-344835-iivry1ou	146	4	the	the	DT
cord-344835-iivry1ou	146	5	above	above	JJ
cord-344835-iivry1ou	146	6	events	event	NNS
cord-344835-iivry1ou	146	7	leads	lead	VBZ
cord-344835-iivry1ou	146	8	to	to	IN
cord-344835-iivry1ou	146	9	significant	significant	JJ
cord-344835-iivry1ou	146	10	airway	airway	NN
cord-344835-iivry1ou	146	11	narrowing	narrowing	NN
cord-344835-iivry1ou	146	12	and	and	CC
cord-344835-iivry1ou	146	13	increased	increased	JJ
cord-344835-iivry1ou	146	14	airway	airway	NN
cord-344835-iivry1ou	146	15	secretions	secretion	NNS
cord-344835-iivry1ou	146	16	,	,	,
cord-344835-iivry1ou	146	17	while	while	IN
cord-344835-iivry1ou	146	18	the	the	DT
cord-344835-iivry1ou	146	19	patient	patient	NN
cord-344835-iivry1ou	146	20	suffers	suffer	VBZ
cord-344835-iivry1ou	146	21	from	from	IN
cord-344835-iivry1ou	146	22	increased	increase	VBN
cord-344835-iivry1ou	146	23	cough	cough	NN
cord-344835-iivry1ou	146	24	,	,	,
cord-344835-iivry1ou	146	25	sputum	sputum	NN
cord-344835-iivry1ou	146	26	,	,	,
cord-344835-iivry1ou	146	27	and/or	and/or	CC
cord-344835-iivry1ou	146	28	increased	increase	VBN
cord-344835-iivry1ou	146	29	dyspnea	dyspnea	NN
cord-344835-iivry1ou	146	30	.	.	.
cord-344835-iivry1ou	147	1	The	the	DT
cord-344835-iivry1ou	147	2	mechanisms	mechanism	NNS
cord-344835-iivry1ou	147	3	of	of	IN
cord-344835-iivry1ou	147	4	dyspnea	dyspnea	NN
cord-344835-iivry1ou	147	5	are	be	VBP
cord-344835-iivry1ou	147	6	not	not	RB
cord-344835-iivry1ou	147	7	entirely	entirely	RB
cord-344835-iivry1ou	147	8	understood	understand	VBN
cord-344835-iivry1ou	147	9	yet	yet	RB
cord-344835-iivry1ou	147	10	,	,	,
cord-344835-iivry1ou	147	11	but	but	CC
cord-344835-iivry1ou	147	12	may	may	MD
cord-344835-iivry1ou	147	13	be	be	VB
cord-344835-iivry1ou	147	14	also	also	RB
cord-344835-iivry1ou	147	15	associated	associate	VBN
cord-344835-iivry1ou	147	16	with	with	IN
cord-344835-iivry1ou	147	17	excessive	excessive	JJ
cord-344835-iivry1ou	147	18	airway	airway	NN
cord-344835-iivry1ou	147	19	narrowing	narrowing	NN
cord-344835-iivry1ou	147	20	and	and	CC
cord-344835-iivry1ou	147	21	dynamic	dynamic	JJ
cord-344835-iivry1ou	147	22	hyperinflation	hyperinflation	NN
cord-344835-iivry1ou	147	23	due	due	IN
cord-344835-iivry1ou	147	24	to	to	IN
cord-344835-iivry1ou	147	25	increased	increase	VBN
cord-344835-iivry1ou	147	26	inflammation	inflammation	NN
cord-344835-iivry1ou	147	27	[	[	-LRB-
cord-344835-iivry1ou	147	28	88	88	CD
cord-344835-iivry1ou	147	29	]	]	-RRB-
cord-344835-iivry1ou	147	30	[	[	-LRB-
cord-344835-iivry1ou	147	31	89	89	CD
cord-344835-iivry1ou	147	32	]	]	-RRB-
cord-344835-iivry1ou	147	33	[	[	-LRB-
cord-344835-iivry1ou	147	34	90	90	CD
cord-344835-iivry1ou	147	35	]	]	-RRB-
cord-344835-iivry1ou	147	36	.	.	.
cord-344835-iivry1ou	148	1	A	a	DT
cord-344835-iivry1ou	148	2	brief	brief	JJ
cord-344835-iivry1ou	148	3	summary	summary	NN
cord-344835-iivry1ou	148	4	of	of	IN
cord-344835-iivry1ou	148	5	the	the	DT
cord-344835-iivry1ou	148	6	pathophysiologic	pathophysiologic	JJ
cord-344835-iivry1ou	148	7	events	event	NNS
cord-344835-iivry1ou	148	8	that	that	WDT
cord-344835-iivry1ou	148	9	may	may	MD
cord-344835-iivry1ou	148	10	link	link	VB
cord-344835-iivry1ou	148	11	airway	airway	NN
cord-344835-iivry1ou	148	12	inflammation	inflammation	NN
cord-344835-iivry1ou	148	13	to	to	IN
cord-344835-iivry1ou	148	14	the	the	DT
cord-344835-iivry1ou	148	15	symptoms	symptom	NNS
cord-344835-iivry1ou	148	16	of	of	IN
cord-344835-iivry1ou	148	17	COPD	COPD	NNP
cord-344835-iivry1ou	148	18	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	148	19	and	and	CC
cord-344835-iivry1ou	148	20	to	to	IN
cord-344835-iivry1ou	148	21	respiratory	respiratory	JJ
cord-344835-iivry1ou	148	22	failure	failure	NN
cord-344835-iivry1ou	148	23	is	be	VBZ
cord-344835-iivry1ou	148	24	given	give	VBN
cord-344835-iivry1ou	148	25	in	in	IN
cord-344835-iivry1ou	148	26	figure	figure	NN
cord-344835-iivry1ou	148	27	 	 	_SP
cord-344835-iivry1ou	148	28	1	1	CD
cord-344835-iivry1ou	148	29	.	.	.
cord-344835-iivry1ou	149	1	Airway	airway	NN
cord-344835-iivry1ou	149	2	narrowing	narrowing	NN
cord-344835-iivry1ou	149	3	,	,	,
cord-344835-iivry1ou	149	4	caused	cause	VBN
cord-344835-iivry1ou	149	5	by	by	IN
cord-344835-iivry1ou	149	6	increased	increase	VBN
cord-344835-iivry1ou	149	7	inflammation	inflammation	NN
cord-344835-iivry1ou	149	8	,	,	,
cord-344835-iivry1ou	149	9	leads	lead	VBZ
cord-344835-iivry1ou	149	10	to	to	TO
cord-344835-iivry1ou	149	11	expiratory	expiratory	VB
cord-344835-iivry1ou	149	12	flow	flow	NN
cord-344835-iivry1ou	149	13	limitation	limitation	NN
cord-344835-iivry1ou	149	14	and	and	CC
cord-344835-iivry1ou	149	15	dynamic	dynamic	JJ
cord-344835-iivry1ou	149	16	hyperinflation	hyperinflation	NN
cord-344835-iivry1ou	149	17	.	.	.
cord-344835-iivry1ou	150	1	Dynamic	dynamic	JJ
cord-344835-iivry1ou	150	2	hyperinflation	hyperinflation	NN
cord-344835-iivry1ou	150	3	in	in	IN
cord-344835-iivry1ou	150	4	turn	turn	NN
cord-344835-iivry1ou	150	5	increases	increase	VBZ
cord-344835-iivry1ou	150	6	work	work	NN
cord-344835-iivry1ou	150	7	of	of	IN
cord-344835-iivry1ou	150	8	respiratory	respiratory	JJ
cord-344835-iivry1ou	150	9	muscles	muscle	NNS
cord-344835-iivry1ou	150	10	and	and	CC
cord-344835-iivry1ou	150	11	oxygen	oxygen	NN
cord-344835-iivry1ou	150	12	consumption	consumption	NN
cord-344835-iivry1ou	150	13	,	,	,
cord-344835-iivry1ou	150	14	resulting	result	VBG
cord-344835-iivry1ou	150	15	in	in	IN
cord-344835-iivry1ou	150	16	decreased	decreased	JJ
cord-344835-iivry1ou	150	17	mixed	mixed	JJ
cord-344835-iivry1ou	150	18	venous	venous	JJ
cord-344835-iivry1ou	150	19	oxygen	oxygen	NN
cord-344835-iivry1ou	150	20	tension	tension	NN
cord-344835-iivry1ou	150	21	[	[	-LRB-
cord-344835-iivry1ou	150	22	91	91	CD
cord-344835-iivry1ou	150	23	]	]	-RRB-
cord-344835-iivry1ou	150	24	.	.	.
cord-344835-iivry1ou	151	1	Airway	airway	NN
cord-344835-iivry1ou	151	2	narrowing	narrowing	NN
cord-344835-iivry1ou	151	3	also	also	RB
cord-344835-iivry1ou	151	4	increases	increase	VBZ
cord-344835-iivry1ou	151	5	ventilation	ventilation	NN
cord-344835-iivry1ou	151	6	/	/	SYM
cord-344835-iivry1ou	151	7	perfusion	perfusion	NN
cord-344835-iivry1ou	151	8	inequality	inequality	NN
cord-344835-iivry1ou	151	9	,	,	,
cord-344835-iivry1ou	151	10	because	because	IN
cord-344835-iivry1ou	151	11	a	a	DT
cord-344835-iivry1ou	151	12	greater	great	JJR
cord-344835-iivry1ou	151	13	proportion	proportion	NN
cord-344835-iivry1ou	151	14	of	of	IN
cord-344835-iivry1ou	151	15	blood	blood	NN
cord-344835-iivry1ou	151	16	flow	flow	NN
cord-344835-iivry1ou	151	17	is	be	VBZ
cord-344835-iivry1ou	151	18	diverted	divert	VBN
cord-344835-iivry1ou	151	19	through	through	IN
cord-344835-iivry1ou	151	20	lung	lung	NN
cord-344835-iivry1ou	151	21	units	unit	NNS
cord-344835-iivry1ou	151	22	with	with	IN
cord-344835-iivry1ou	151	23	low	low	JJ
cord-344835-iivry1ou	151	24	V'/Q	v'/q	NN
cord-344835-iivry1ou	151	25	'	'	''
cord-344835-iivry1ou	151	26	ratios	ratio	NNS
cord-344835-iivry1ou	151	27	[	[	-LRB-
cord-344835-iivry1ou	151	28	91	91	CD
cord-344835-iivry1ou	151	29	]	]	-RRB-
cord-344835-iivry1ou	151	30	.	.	.
cord-344835-iivry1ou	152	1	The	the	DT
cord-344835-iivry1ou	152	2	combi	combi	NN
cord-344835-iivry1ou	152	3	-	-	HYPH
cord-344835-iivry1ou	152	4	Schematic	schematic	JJ
cord-344835-iivry1ou	152	5	presentation	presentation	NN
cord-344835-iivry1ou	152	6	of	of	IN
cord-344835-iivry1ou	152	7	the	the	DT
cord-344835-iivry1ou	152	8	main	main	JJ
cord-344835-iivry1ou	152	9	pathophysiologic	pathophysiologic	JJ
cord-344835-iivry1ou	152	10	events	event	NNS
cord-344835-iivry1ou	152	11	of	of	IN
cord-344835-iivry1ou	152	12	COPD	COPD	NNP
cord-344835-iivry1ou	152	13	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	152	14	,	,	,
cord-344835-iivry1ou	152	15	starting	start	VBG
cord-344835-iivry1ou	152	16	from	from	IN
cord-344835-iivry1ou	152	17	increased	increase	VBN
cord-344835-iivry1ou	152	18	airway	airway	NNP
cord-344835-iivry1ou	152	19	inflamma	inflamma	NNP
cord-344835-iivry1ou	152	20	-	-	HYPH
cord-344835-iivry1ou	152	21	tion	tion	NNP
cord-344835-iivry1ou	152	22	Figure	figure	NN
cord-344835-iivry1ou	152	23	1	1	CD
cord-344835-iivry1ou	152	24	Schematic	schematic	JJ
cord-344835-iivry1ou	152	25	presentation	presentation	NN
cord-344835-iivry1ou	152	26	of	of	IN
cord-344835-iivry1ou	152	27	the	the	DT
cord-344835-iivry1ou	152	28	main	main	JJ
cord-344835-iivry1ou	152	29	pathophysiologic	pathophysiologic	JJ
cord-344835-iivry1ou	152	30	events	event	NNS
cord-344835-iivry1ou	152	31	of	of	IN
cord-344835-iivry1ou	152	32	COPD	COPD	NNP
cord-344835-iivry1ou	152	33	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	152	34	,	,	,
cord-344835-iivry1ou	152	35	starting	start	VBG
cord-344835-iivry1ou	152	36	from	from	IN
cord-344835-iivry1ou	152	37	increased	increase	VBN
cord-344835-iivry1ou	152	38	airway	airway	NN
cord-344835-iivry1ou	152	39	inflammation	inflammation	NN
cord-344835-iivry1ou	152	40	.	.	.
cord-344835-iivry1ou	153	1	nation	nation	NN
cord-344835-iivry1ou	153	2	of	of	IN
cord-344835-iivry1ou	153	3	increased	increase	VBN
cord-344835-iivry1ou	153	4	ventilation	ventilation	NN
cord-344835-iivry1ou	153	5	/	/	SYM
cord-344835-iivry1ou	153	6	perfusion	perfusion	NN
cord-344835-iivry1ou	153	7	inequality	inequality	NN
cord-344835-iivry1ou	153	8	and	and	CC
cord-344835-iivry1ou	153	9	decreased	decrease	VBD
cord-344835-iivry1ou	153	10	mixed	mixed	JJ
cord-344835-iivry1ou	153	11	venous	venous	JJ
cord-344835-iivry1ou	153	12	oxygen	oxygen	NN
cord-344835-iivry1ou	153	13	tension	tension	NN
cord-344835-iivry1ou	153	14	significantly	significantly	RB
cord-344835-iivry1ou	153	15	worsen	worsen	VBP
cord-344835-iivry1ou	153	16	gas	gas	NN
cord-344835-iivry1ou	153	17	exchange	exchange	NN
cord-344835-iivry1ou	153	18	in	in	IN
cord-344835-iivry1ou	153	19	patients	patient	NNS
cord-344835-iivry1ou	153	20	with	with	IN
cord-344835-iivry1ou	153	21	severe	severe	JJ
cord-344835-iivry1ou	153	22	COPD	COPD	NNP
cord-344835-iivry1ou	153	23	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	153	24	.	.	.
cord-344835-iivry1ou	154	1	Increased	increase	VBN
cord-344835-iivry1ou	154	2	airway	airway	NN
cord-344835-iivry1ou	154	3	inflammation	inflammation	NN
cord-344835-iivry1ou	154	4	would	would	MD
cord-344835-iivry1ou	154	5	be	be	VB
cord-344835-iivry1ou	154	6	also	also	RB
cord-344835-iivry1ou	154	7	expected	expect	VBN
cord-344835-iivry1ou	154	8	to	to	TO
cord-344835-iivry1ou	154	9	increase	increase	VB
cord-344835-iivry1ou	154	10	lung	lung	NN
cord-344835-iivry1ou	154	11	tissue	tissue	NN
cord-344835-iivry1ou	154	12	oxygen	oxygen	NN
cord-344835-iivry1ou	154	13	demand	demand	NN
cord-344835-iivry1ou	154	14	and	and	CC
cord-344835-iivry1ou	154	15	oxygen	oxygen	NN
cord-344835-iivry1ou	154	16	consumption	consumption	NN
cord-344835-iivry1ou	154	17	.	.	.
cord-344835-iivry1ou	155	1	In	in	IN
cord-344835-iivry1ou	155	2	patients	patient	NNS
cord-344835-iivry1ou	155	3	with	with	IN
cord-344835-iivry1ou	155	4	acute	acute	JJ
cord-344835-iivry1ou	155	5	lung	lung	NN
cord-344835-iivry1ou	155	6	injury	injury	NN
cord-344835-iivry1ou	155	7	no	no	DT
cord-344835-iivry1ou	155	8	relation	relation	NN
cord-344835-iivry1ou	155	9	has	have	VBZ
cord-344835-iivry1ou	155	10	been	be	VBN
cord-344835-iivry1ou	155	11	found	find	VBN
cord-344835-iivry1ou	155	12	between	between	IN
cord-344835-iivry1ou	155	13	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	155	14	oxygen	oxygen	NN
cord-344835-iivry1ou	155	15	consumption	consumption	NN
cord-344835-iivry1ou	155	16	and	and	CC
cord-344835-iivry1ou	155	17	lung	lung	NN
cord-344835-iivry1ou	155	18	inflammation	inflammation	NN
cord-344835-iivry1ou	155	19	,	,	,
cord-344835-iivry1ou	155	20	but	but	CC
cord-344835-iivry1ou	155	21	there	there	EX
cord-344835-iivry1ou	155	22	is	be	VBZ
cord-344835-iivry1ou	155	23	no	no	DT
cord-344835-iivry1ou	155	24	relevant	relevant	JJ
cord-344835-iivry1ou	155	25	data	datum	NNS
cord-344835-iivry1ou	155	26	in	in	IN
cord-344835-iivry1ou	155	27	COPD	COPD	NNP
cord-344835-iivry1ou	155	28	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	155	29	[	[	-LRB-
cord-344835-iivry1ou	155	30	92	92	CD
cord-344835-iivry1ou	155	31	]	]	-RRB-
cord-344835-iivry1ou	155	32	.	.	.
cord-344835-iivry1ou	156	1	Despite	despite	IN
cord-344835-iivry1ou	156	2	the	the	DT
cord-344835-iivry1ou	156	3	increasing	increase	VBG
cord-344835-iivry1ou	156	4	recognition	recognition	NN
cord-344835-iivry1ou	156	5	of	of	IN
cord-344835-iivry1ou	156	6	the	the	DT
cord-344835-iivry1ou	156	7	importance	importance	NN
cord-344835-iivry1ou	156	8	of	of	IN
cord-344835-iivry1ou	156	9	airway	airway	JJ
cord-344835-iivry1ou	156	10	inflammation	inflammation	NN
cord-344835-iivry1ou	156	11	in	in	IN
cord-344835-iivry1ou	156	12	the	the	DT
cord-344835-iivry1ou	156	13	development	development	NN
cord-344835-iivry1ou	156	14	of	of	IN
cord-344835-iivry1ou	156	15	COPD	COPD	NNP
cord-344835-iivry1ou	156	16	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	156	17	,	,	,
cord-344835-iivry1ou	156	18	there	there	EX
cord-344835-iivry1ou	156	19	is	be	VBZ
cord-344835-iivry1ou	156	20	still	still	RB
cord-344835-iivry1ou	156	21	confusion	confusion	NN
cord-344835-iivry1ou	156	22	regarding	regard	VBG
cord-344835-iivry1ou	156	23	the	the	DT
cord-344835-iivry1ou	156	24	role	role	NN
cord-344835-iivry1ou	156	25	of	of	IN
cord-344835-iivry1ou	156	26	anti	anti	JJ
cord-344835-iivry1ou	156	27	-	-	JJ
cord-344835-iivry1ou	156	28	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	156	29	strategies	strategy	NNS
cord-344835-iivry1ou	156	30	in	in	IN
cord-344835-iivry1ou	156	31	the	the	DT
cord-344835-iivry1ou	156	32	prevention	prevention	NN
cord-344835-iivry1ou	156	33	and	and	CC
cord-344835-iivry1ou	156	34	treatment	treatment	NN
cord-344835-iivry1ou	156	35	of	of	IN
cord-344835-iivry1ou	156	36	COPD	COPD	NNP
cord-344835-iivry1ou	156	37	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	156	38	[	[	-LRB-
cord-344835-iivry1ou	156	39	93	93	CD
cord-344835-iivry1ou	156	40	,	,	,
cord-344835-iivry1ou	156	41	94	94	CD
cord-344835-iivry1ou	156	42	]	]	-RRB-
cord-344835-iivry1ou	156	43	.	.	.
cord-344835-iivry1ou	157	1	There	there	EX
cord-344835-iivry1ou	157	2	are	be	VBP
cord-344835-iivry1ou	157	3	studies	study	NNS
cord-344835-iivry1ou	157	4	showing	show	VBG
cord-344835-iivry1ou	157	5	a	a	DT
cord-344835-iivry1ou	157	6	beneficial	beneficial	JJ
cord-344835-iivry1ou	157	7	effect	effect	NN
cord-344835-iivry1ou	157	8	of	of	IN
cord-344835-iivry1ou	157	9	inhaled	inhale	VBN
cord-344835-iivry1ou	157	10	steroids	steroid	NNS
cord-344835-iivry1ou	157	11	in	in	IN
cord-344835-iivry1ou	157	12	preventing	prevent	VBG
cord-344835-iivry1ou	157	13	COPD	COPD	NNP
cord-344835-iivry1ou	157	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	157	15	and	and	CC
cord-344835-iivry1ou	157	16	systemic	systemic	JJ
cord-344835-iivry1ou	157	17	steroids	steroid	NNS
cord-344835-iivry1ou	157	18	in	in	IN
cord-344835-iivry1ou	157	19	treating	treat	VBG
cord-344835-iivry1ou	157	20	acute	acute	JJ
cord-344835-iivry1ou	157	21	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	157	22	,	,	,
cord-344835-iivry1ou	157	23	however	however	RB
cord-344835-iivry1ou	157	24	the	the	DT
cord-344835-iivry1ou	157	25	overall	overall	JJ
cord-344835-iivry1ou	157	26	benefits	benefit	NNS
cord-344835-iivry1ou	157	27	for	for	IN
cord-344835-iivry1ou	157	28	COPD	COPD	NNP
cord-344835-iivry1ou	157	29	patients	patient	NNS
cord-344835-iivry1ou	157	30	in	in	IN
cord-344835-iivry1ou	157	31	these	these	DT
cord-344835-iivry1ou	157	32	studies	study	NNS
cord-344835-iivry1ou	157	33	are	be	VBP
cord-344835-iivry1ou	157	34	generally	generally	RB
cord-344835-iivry1ou	157	35	modest	modest	JJ
cord-344835-iivry1ou	157	36	[	[	-LRB-
cord-344835-iivry1ou	157	37	95	95	CD
cord-344835-iivry1ou	157	38	]	]	-RRB-
cord-344835-iivry1ou	157	39	[	[	-LRB-
cord-344835-iivry1ou	157	40	96	96	CD
cord-344835-iivry1ou	157	41	]	]	-RRB-
cord-344835-iivry1ou	157	42	[	[	-LRB-
cord-344835-iivry1ou	157	43	97	97	CD
cord-344835-iivry1ou	157	44	]	]	-RRB-
cord-344835-iivry1ou	157	45	.	.	.
cord-344835-iivry1ou	158	1	Considering	consider	VBG
cord-344835-iivry1ou	158	2	that	that	DT
cord-344835-iivry1ou	158	3	inflammation	inflammation	NN
cord-344835-iivry1ou	158	4	in	in	IN
cord-344835-iivry1ou	158	5	stable	stable	JJ
cord-344835-iivry1ou	158	6	COPD	COPD	NNP
cord-344835-iivry1ou	158	7	is	be	VBZ
cord-344835-iivry1ou	158	8	steroid	steroid	NN
cord-344835-iivry1ou	158	9	resistant	resistant	NN
cord-344835-iivry1ou	158	10	,	,	,
cord-344835-iivry1ou	158	11	this	this	DT
cord-344835-iivry1ou	158	12	should	should	MD
cord-344835-iivry1ou	158	13	not	not	RB
cord-344835-iivry1ou	158	14	come	come	VB
cord-344835-iivry1ou	158	15	as	as	IN
cord-344835-iivry1ou	158	16	a	a	DT
cord-344835-iivry1ou	158	17	great	great	JJ
cord-344835-iivry1ou	158	18	surprise	surprise	NN
cord-344835-iivry1ou	158	19	[	[	-LRB-
cord-344835-iivry1ou	158	20	98	98	CD
cord-344835-iivry1ou	158	21	]	]	-RRB-
cord-344835-iivry1ou	158	22	.	.	.
cord-344835-iivry1ou	159	1	Although	although	IN
cord-344835-iivry1ou	159	2	the	the	DT
cord-344835-iivry1ou	159	3	majority	majority	NN
cord-344835-iivry1ou	159	4	of	of	IN
cord-344835-iivry1ou	159	5	COPD	COPD	NNP
cord-344835-iivry1ou	159	6	patients	patient	NNS
cord-344835-iivry1ou	159	7	respond	respond	VBP
cord-344835-iivry1ou	159	8	modestly	modestly	RB
cord-344835-iivry1ou	159	9	to	to	IN
cord-344835-iivry1ou	159	10	steroid	steroid	NN
cord-344835-iivry1ou	159	11	therapy	therapy	NN
cord-344835-iivry1ou	159	12	,	,	,
cord-344835-iivry1ou	159	13	there	there	EX
cord-344835-iivry1ou	159	14	might	may	MD
cord-344835-iivry1ou	159	15	be	be	VB
cord-344835-iivry1ou	159	16	subgroup	subgroup	RB
cord-344835-iivry1ou	159	17	of	of	IN
cord-344835-iivry1ou	159	18	patients	patient	NNS
cord-344835-iivry1ou	159	19	,	,	,
cord-344835-iivry1ou	159	20	those	those	DT
cord-344835-iivry1ou	159	21	with	with	IN
cord-344835-iivry1ou	159	22	eosinophilic	eosinophilic	JJ
cord-344835-iivry1ou	159	23	pattern	pattern	NN
cord-344835-iivry1ou	159	24	of	of	IN
cord-344835-iivry1ou	159	25	inflammation	inflammation	NN
cord-344835-iivry1ou	159	26	during	during	IN
cord-344835-iivry1ou	159	27	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	159	28	that	that	WDT
cord-344835-iivry1ou	159	29	may	may	MD
cord-344835-iivry1ou	159	30	benefit	benefit	VB
cord-344835-iivry1ou	159	31	the	the	DT
cord-344835-iivry1ou	159	32	most	most	JJS
cord-344835-iivry1ou	159	33	from	from	IN
cord-344835-iivry1ou	159	34	steroid	steroid	NNP
cord-344835-iivry1ou	159	35	administration	administration	NN
cord-344835-iivry1ou	159	36	.	.	.
cord-344835-iivry1ou	160	1	There	there	EX
cord-344835-iivry1ou	160	2	is	be	VBZ
cord-344835-iivry1ou	160	3	already	already	RB
cord-344835-iivry1ou	160	4	evidence	evidence	NN
cord-344835-iivry1ou	160	5	that	that	IN
cord-344835-iivry1ou	160	6	stable	stable	JJ
cord-344835-iivry1ou	160	7	patients	patient	NNS
cord-344835-iivry1ou	160	8	with	with	IN
cord-344835-iivry1ou	160	9	high	high	JJ
cord-344835-iivry1ou	160	10	sputum	sputum	NN
cord-344835-iivry1ou	160	11	eosinophil	eosinophil	NN
cord-344835-iivry1ou	160	12	counts	count	NNS
cord-344835-iivry1ou	160	13	are	be	VBP
cord-344835-iivry1ou	160	14	steroid	steroid	NN
cord-344835-iivry1ou	160	15	responsive	responsive	JJ
cord-344835-iivry1ou	160	16	,	,	,
cord-344835-iivry1ou	160	17	but	but	CC
cord-344835-iivry1ou	160	18	there	there	EX
cord-344835-iivry1ou	160	19	is	be	VBZ
cord-344835-iivry1ou	160	20	no	no	DT
cord-344835-iivry1ou	160	21	relevant	relevant	JJ
cord-344835-iivry1ou	160	22	data	datum	NNS
cord-344835-iivry1ou	160	23	on	on	IN
cord-344835-iivry1ou	160	24	COPD	COPD	NNP
cord-344835-iivry1ou	160	25	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	160	26	[	[	-LRB-
cord-344835-iivry1ou	160	27	99	99	CD
cord-344835-iivry1ou	160	28	,	,	,
cord-344835-iivry1ou	160	29	100	100	CD
cord-344835-iivry1ou	160	30	]	]	-RRB-
cord-344835-iivry1ou	160	31	.	.	.
cord-344835-iivry1ou	161	1	Identifying	identify	VBG
cord-344835-iivry1ou	161	2	patients	patient	NNS
cord-344835-iivry1ou	161	3	that	that	WDT
cord-344835-iivry1ou	161	4	may	may	MD
cord-344835-iivry1ou	161	5	benefit	benefit	VB
cord-344835-iivry1ou	161	6	from	from	IN
cord-344835-iivry1ou	161	7	systemic	systemic	JJ
cord-344835-iivry1ou	161	8	steroid	steroid	JJ
cord-344835-iivry1ou	161	9	administration	administration	NN
cord-344835-iivry1ou	161	10	during	during	IN
cord-344835-iivry1ou	161	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	161	12	is	be	VBZ
cord-344835-iivry1ou	161	13	of	of	IN
cord-344835-iivry1ou	161	14	great	great	JJ
cord-344835-iivry1ou	161	15	importance	importance	NN
cord-344835-iivry1ou	161	16	,	,	,
cord-344835-iivry1ou	161	17	due	due	IN
cord-344835-iivry1ou	161	18	to	to	IN
cord-344835-iivry1ou	161	19	the	the	DT
cord-344835-iivry1ou	161	20	serious	serious	JJ
cord-344835-iivry1ou	161	21	adverse	adverse	JJ
cord-344835-iivry1ou	161	22	events	event	NNS
cord-344835-iivry1ou	161	23	frequently	frequently	RB
cord-344835-iivry1ou	161	24	observed	observe	VBD
cord-344835-iivry1ou	161	25	with	with	IN
cord-344835-iivry1ou	161	26	this	this	DT
cord-344835-iivry1ou	161	27	kind	kind	NN
cord-344835-iivry1ou	161	28	of	of	IN
cord-344835-iivry1ou	161	29	treatment	treatment	NN
cord-344835-iivry1ou	161	30	[	[	-LRB-
cord-344835-iivry1ou	161	31	97	97	CD
cord-344835-iivry1ou	161	32	]	]	-RRB-
cord-344835-iivry1ou	161	33	.	.	.
cord-344835-iivry1ou	162	1	Other	other	JJ
cord-344835-iivry1ou	162	2	drugs	drug	NNS
cord-344835-iivry1ou	162	3	with	with	IN
cord-344835-iivry1ou	162	4	anti	anti	JJ
cord-344835-iivry1ou	162	5	-	-	JJ
cord-344835-iivry1ou	162	6	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	162	7	properties	property	NNS
cord-344835-iivry1ou	162	8	,	,	,
cord-344835-iivry1ou	162	9	like	like	IN
cord-344835-iivry1ou	162	10	methylxanthines	methylxanthine	NNS
cord-344835-iivry1ou	162	11	and	and	CC
cord-344835-iivry1ou	162	12	mucolytic	mucolytic	JJ
cord-344835-iivry1ou	162	13	agents	agent	NNS
cord-344835-iivry1ou	162	14	seem	seem	VBP
cord-344835-iivry1ou	162	15	not	not	RB
cord-344835-iivry1ou	162	16	to	to	TO
cord-344835-iivry1ou	162	17	be	be	VB
cord-344835-iivry1ou	162	18	effective	effective	JJ
cord-344835-iivry1ou	162	19	on	on	IN
cord-344835-iivry1ou	162	20	COPD	COPD	NNP
cord-344835-iivry1ou	162	21	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	162	22	[	[	-LRB-
cord-344835-iivry1ou	162	23	8	8	CD
cord-344835-iivry1ou	162	24	]	]	-RRB-
cord-344835-iivry1ou	162	25	.	.	.
cord-344835-iivry1ou	163	1	B	b	NN
cord-344835-iivry1ou	163	2	-	-	HYPH
cord-344835-iivry1ou	163	3	agonists	agonist	NNS
cord-344835-iivry1ou	163	4	are	be	VBP
cord-344835-iivry1ou	163	5	mainly	mainly	RB
cord-344835-iivry1ou	163	6	administered	administer	VBN
cord-344835-iivry1ou	163	7	as	as	IN
cord-344835-iivry1ou	163	8	bronchodilators	bronchodilator	NNS
cord-344835-iivry1ou	163	9	,	,	,
cord-344835-iivry1ou	163	10	although	although	IN
cord-344835-iivry1ou	163	11	they	-PRON-	PRP
cord-344835-iivry1ou	163	12	may	may	MD
cord-344835-iivry1ou	163	13	also	also	RB
cord-344835-iivry1ou	163	14	have	have	VB
cord-344835-iivry1ou	163	15	an	an	DT
cord-344835-iivry1ou	163	16	anti	anti	JJ
cord-344835-iivry1ou	163	17	-	-	JJ
cord-344835-iivry1ou	163	18	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	163	19	role	role	NN
cord-344835-iivry1ou	163	20	[	[	-LRB-
cord-344835-iivry1ou	163	21	101	101	CD
cord-344835-iivry1ou	163	22	]	]	-RRB-
cord-344835-iivry1ou	163	23	.	.	.
cord-344835-iivry1ou	164	1	Novel	novel	JJ
cord-344835-iivry1ou	164	2	drugs	drug	NNS
cord-344835-iivry1ou	164	3	aimed	aim	VBN
cord-344835-iivry1ou	164	4	at	at	IN
cord-344835-iivry1ou	164	5	inhibiting	inhibit	VBG
cord-344835-iivry1ou	164	6	targets	target	NNS
cord-344835-iivry1ou	164	7	,	,	,
cord-344835-iivry1ou	164	8	including	include	VBG
cord-344835-iivry1ou	164	9	NO	no	DT
cord-344835-iivry1ou	164	10	synthase	synthase	NN
cord-344835-iivry1ou	164	11	,	,	,
cord-344835-iivry1ou	164	12	phosphodiesterase	phosphodiesterase	NN
cord-344835-iivry1ou	164	13	4	4	CD
cord-344835-iivry1ou	164	14	,	,	,
cord-344835-iivry1ou	164	15	proteases	protease	NNS
cord-344835-iivry1ou	164	16	and	and	CC
cord-344835-iivry1ou	164	17	various	various	JJ
cord-344835-iivry1ou	164	18	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	164	19	mediators	mediator	NNS
cord-344835-iivry1ou	164	20	have	have	VBP
cord-344835-iivry1ou	164	21	not	not	RB
cord-344835-iivry1ou	164	22	been	be	VBN
cord-344835-iivry1ou	164	23	tested	test	VBN
cord-344835-iivry1ou	164	24	during	during	IN
cord-344835-iivry1ou	164	25	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	164	26	yet	yet	RB
cord-344835-iivry1ou	164	27	.	.	.
cord-344835-iivry1ou	165	1	It	-PRON-	PRP
cord-344835-iivry1ou	165	2	has	have	VBZ
cord-344835-iivry1ou	165	3	been	be	VBN
cord-344835-iivry1ou	165	4	long	long	RB
cord-344835-iivry1ou	165	5	postulated	postulate	VBN
cord-344835-iivry1ou	165	6	that	that	IN
cord-344835-iivry1ou	165	7	airway	airway	JJ
cord-344835-iivry1ou	165	8	inflammation	inflammation	NN
cord-344835-iivry1ou	165	9	may	may	MD
cord-344835-iivry1ou	165	10	be	be	VB
cord-344835-iivry1ou	165	11	increased	increase	VBN
cord-344835-iivry1ou	165	12	during	during	IN
cord-344835-iivry1ou	165	13	COPD	COPD	NNP
cord-344835-iivry1ou	165	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	165	15	and	and	CC
cord-344835-iivry1ou	165	16	this	this	DT
cord-344835-iivry1ou	165	17	may	may	MD
cord-344835-iivry1ou	165	18	be	be	VB
cord-344835-iivry1ou	165	19	involved	involve	VBN
cord-344835-iivry1ou	165	20	in	in	IN
cord-344835-iivry1ou	165	21	the	the	DT
cord-344835-iivry1ou	165	22	pathophysiology	pathophysiology	NN
cord-344835-iivry1ou	165	23	of	of	IN
cord-344835-iivry1ou	165	24	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	165	25	.	.	.
cord-344835-iivry1ou	166	1	There	there	EX
cord-344835-iivry1ou	166	2	is	be	VBZ
cord-344835-iivry1ou	166	3	now	now	RB
cord-344835-iivry1ou	166	4	sufficient	sufficient	JJ
cord-344835-iivry1ou	166	5	data	datum	NNS
cord-344835-iivry1ou	166	6	to	to	TO
cord-344835-iivry1ou	166	7	support	support	VB
cord-344835-iivry1ou	166	8	such	such	PDT
cord-344835-iivry1ou	166	9	a	a	DT
cord-344835-iivry1ou	166	10	hypothesis	hypothesis	NN
cord-344835-iivry1ou	166	11	.	.	.
cord-344835-iivry1ou	167	1	Firstly	firstly	RB
cord-344835-iivry1ou	167	2	,	,	,
cord-344835-iivry1ou	167	3	there	there	EX
cord-344835-iivry1ou	167	4	are	be	VBP
cord-344835-iivry1ou	167	5	accumulating	accumulate	VBG
cord-344835-iivry1ou	167	6	observations	observation	NNS
cord-344835-iivry1ou	167	7	for	for	IN
cord-344835-iivry1ou	167	8	increased	increase	VBN
cord-344835-iivry1ou	167	9	inflammation	inflammation	NN
cord-344835-iivry1ou	167	10	during	during	IN
cord-344835-iivry1ou	167	11	COPD	COPD	NNP
cord-344835-iivry1ou	167	12	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	167	13	.	.	.
cord-344835-iivry1ou	168	1	Secondly	secondly	RB
cord-344835-iivry1ou	168	2	,	,	,
cord-344835-iivry1ou	168	3	specific	specific	JJ
cord-344835-iivry1ou	168	4	aetiological	aetiological	JJ
cord-344835-iivry1ou	168	5	factors	factor	NNS
cord-344835-iivry1ou	168	6	for	for	IN
cord-344835-iivry1ou	168	7	this	this	DT
cord-344835-iivry1ou	168	8	increase	increase	NN
cord-344835-iivry1ou	168	9	have	have	VBP
cord-344835-iivry1ou	168	10	been	be	VBN
cord-344835-iivry1ou	168	11	identified	identify	VBN
cord-344835-iivry1ou	168	12	.	.	.
cord-344835-iivry1ou	169	1	Thirdly	thirdly	RB
cord-344835-iivry1ou	169	2	,	,	,
cord-344835-iivry1ou	169	3	possible	possible	JJ
cord-344835-iivry1ou	169	4	mechanisms	mechanism	NNS
cord-344835-iivry1ou	169	5	that	that	WDT
cord-344835-iivry1ou	169	6	may	may	MD
cord-344835-iivry1ou	169	7	link	link	VB
cord-344835-iivry1ou	169	8	airway	airway	NN
cord-344835-iivry1ou	169	9	inflammation	inflammation	NN
cord-344835-iivry1ou	169	10	with	with	IN
cord-344835-iivry1ou	169	11	the	the	DT
cord-344835-iivry1ou	169	12	pathophysiology	pathophysiology	NN
cord-344835-iivry1ou	169	13	of	of	IN
cord-344835-iivry1ou	169	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	169	15	have	have	VBP
cord-344835-iivry1ou	169	16	been	be	VBN
cord-344835-iivry1ou	169	17	unmasked	unmask	VBN
cord-344835-iivry1ou	169	18	.	.	.
cord-344835-iivry1ou	170	1	Despite	despite	IN
cord-344835-iivry1ou	170	2	significant	significant	JJ
cord-344835-iivry1ou	170	3	advances	advance	NNS
cord-344835-iivry1ou	170	4	in	in	IN
cord-344835-iivry1ou	170	5	our	-PRON-	PRP$
cord-344835-iivry1ou	170	6	understanding	understanding	NN
cord-344835-iivry1ou	170	7	of	of	IN
cord-344835-iivry1ou	170	8	the	the	DT
cord-344835-iivry1ou	170	9	role	role	NN
cord-344835-iivry1ou	170	10	of	of	IN
cord-344835-iivry1ou	170	11	inflammation	inflammation	NN
cord-344835-iivry1ou	170	12	in	in	IN
cord-344835-iivry1ou	170	13	COPD	COPD	NNP
cord-344835-iivry1ou	170	14	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	170	15	,	,	,
cord-344835-iivry1ou	170	16	the	the	DT
cord-344835-iivry1ou	170	17	existing	exist	VBG
cord-344835-iivry1ou	170	18	anti	anti	JJ
cord-344835-iivry1ou	170	19	-	-	JJ
cord-344835-iivry1ou	170	20	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	170	21	treatments	treatment	NNS
cord-344835-iivry1ou	170	22	remain	remain	VBP
cord-344835-iivry1ou	170	23	modest	modest	JJ
cord-344835-iivry1ou	170	24	and	and	CC
cord-344835-iivry1ou	170	25	there	there	EX
cord-344835-iivry1ou	170	26	is	be	VBZ
cord-344835-iivry1ou	170	27	little	little	JJ
cord-344835-iivry1ou	170	28	overall	overall	JJ
cord-344835-iivry1ou	170	29	benefit	benefit	NN
cord-344835-iivry1ou	170	30	for	for	IN
cord-344835-iivry1ou	170	31	the	the	DT
cord-344835-iivry1ou	170	32	patient	patient	NN
cord-344835-iivry1ou	170	33	.	.	.
cord-344835-iivry1ou	171	1	Further	further	JJ
cord-344835-iivry1ou	171	2	research	research	NN
cord-344835-iivry1ou	171	3	is	be	VBZ
cord-344835-iivry1ou	171	4	needed	need	VBN
cord-344835-iivry1ou	171	5	to	to	TO
cord-344835-iivry1ou	171	6	target	target	VB
cord-344835-iivry1ou	171	7	therapies	therapy	NNS
cord-344835-iivry1ou	171	8	to	to	IN
cord-344835-iivry1ou	171	9	the	the	DT
cord-344835-iivry1ou	171	10	appropriate	appropriate	JJ
cord-344835-iivry1ou	171	11	patient	patient	JJ
cord-344835-iivry1ou	171	12	populations	population	NNS
cord-344835-iivry1ou	171	13	and	and	CC
cord-344835-iivry1ou	171	14	to	to	TO
cord-344835-iivry1ou	171	15	develop	develop	VB
cord-344835-iivry1ou	171	16	new	new	JJ
cord-344835-iivry1ou	171	17	therapeutic	therapeutic	JJ
cord-344835-iivry1ou	171	18	strategies	strategy	NNS
cord-344835-iivry1ou	171	19	.	.	.
cord-344835-iivry1ou	172	1	The	the	DT
cord-344835-iivry1ou	172	2	natural	natural	JJ
cord-344835-iivry1ou	172	3	history	history	NN
cord-344835-iivry1ou	172	4	of	of	IN
cord-344835-iivry1ou	172	5	chronic	chronic	JJ
cord-344835-iivry1ou	172	6	airflow	airflow	NN
cord-344835-iivry1ou	172	7	obstruction	obstruction	NN
cord-344835-iivry1ou	172	8	Effect	effect	NN
cord-344835-iivry1ou	172	9	of	of	IN
cord-344835-iivry1ou	172	10	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	172	11	on	on	IN
cord-344835-iivry1ou	172	12	quality	quality	NN
cord-344835-iivry1ou	172	13	of	of	IN
cord-344835-iivry1ou	172	14	life	life	NN
cord-344835-iivry1ou	172	15	in	in	IN
cord-344835-iivry1ou	172	16	patients	patient	NNS
cord-344835-iivry1ou	172	17	with	with	IN
cord-344835-iivry1ou	172	18	chronic	chronic	JJ
cord-344835-iivry1ou	172	19	obstructive	obstructive	JJ
cord-344835-iivry1ou	172	20	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	172	21	disease	disease	NN
cord-344835-iivry1ou	172	22	:	:	:
cord-344835-iivry1ou	172	23	a	a	DT
cord-344835-iivry1ou	172	24	2	2	CD
cord-344835-iivry1ou	172	25	year	year	NN
cord-344835-iivry1ou	172	26	follow	follow	VB
cord-344835-iivry1ou	172	27	up	up	RP
cord-344835-iivry1ou	172	28	study	study	NN
cord-344835-iivry1ou	172	29	Wedzicha	Wedzicha	NNP
cord-344835-iivry1ou	172	30	JA	JA	NNP
cord-344835-iivry1ou	172	31	:	:	:
cord-344835-iivry1ou	173	1	Effect	effect	NN
cord-344835-iivry1ou	173	2	of	of	IN
cord-344835-iivry1ou	173	3	exacerbation	exacerbation	NN
cord-344835-iivry1ou	173	4	on	on	IN
cord-344835-iivry1ou	173	5	quality	quality	NN
cord-344835-iivry1ou	173	6	of	of	IN
cord-344835-iivry1ou	173	7	life	life	NN
cord-344835-iivry1ou	173	8	in	in	IN
cord-344835-iivry1ou	173	9	patients	patient	NNS
cord-344835-iivry1ou	173	10	with	with	IN
cord-344835-iivry1ou	173	11	chronic	chronic	JJ
cord-344835-iivry1ou	173	12	obstructive	obstructive	JJ
cord-344835-iivry1ou	173	13	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	173	14	disease	disease	NN
cord-344835-iivry1ou	173	15	Course	course	NN
cord-344835-iivry1ou	173	16	and	and	CC
cord-344835-iivry1ou	173	17	prognosis	prognosis	NN
cord-344835-iivry1ou	173	18	of	of	IN
cord-344835-iivry1ou	173	19	chronic	chronic	JJ
cord-344835-iivry1ou	173	20	obstructive	obstructive	JJ
cord-344835-iivry1ou	173	21	lung	lung	NN
cord-344835-iivry1ou	173	22	disease	disease	NN
cord-344835-iivry1ou	173	23	.	.	.
cord-344835-iivry1ou	174	1	A	a	DT
cord-344835-iivry1ou	174	2	prospective	prospective	JJ
cord-344835-iivry1ou	174	3	study	study	NN
cord-344835-iivry1ou	174	4	of	of	IN
cord-344835-iivry1ou	174	5	200	200	CD
cord-344835-iivry1ou	174	6	patients	patient	NNS
cord-344835-iivry1ou	174	7	Relationship	relationship	NN
cord-344835-iivry1ou	174	8	between	between	IN
cord-344835-iivry1ou	174	9	exacerbation	exacerbation	NN
cord-344835-iivry1ou	174	10	frequency	frequency	NN
cord-344835-iivry1ou	174	11	and	and	CC
cord-344835-iivry1ou	174	12	lung	lung	NN
cord-344835-iivry1ou	174	13	function	function	NN
cord-344835-iivry1ou	174	14	decline	decline	NN
cord-344835-iivry1ou	174	15	in	in	IN
cord-344835-iivry1ou	174	16	chronic	chronic	JJ
cord-344835-iivry1ou	174	17	obstructive	obstructive	JJ
cord-344835-iivry1ou	174	18	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	174	19	disease	disease	NN
cord-344835-iivry1ou	175	1	Lower	low	JJR
cord-344835-iivry1ou	175	2	respiratory	respiratory	JJ
cord-344835-iivry1ou	175	3	illnesses	illness	NNS
cord-344835-iivry1ou	175	4	promote	promote	VBP
cord-344835-iivry1ou	175	5	FEV(1	FEV(1	.
cord-344835-iivry1ou	175	6	)	)	-RRB-
cord-344835-iivry1ou	175	7	decline	decline	NN
cord-344835-iivry1ou	175	8	in	in	IN
cord-344835-iivry1ou	175	9	current	current	JJ
cord-344835-iivry1ou	175	10	smokers	smoker	NNS
cord-344835-iivry1ou	175	11	but	but	CC
cord-344835-iivry1ou	175	12	not	not	RB
cord-344835-iivry1ou	175	13	ex	ex	NN
cord-344835-iivry1ou	175	14	-	-	NNS
cord-344835-iivry1ou	175	15	smokers	smoker	NNS
cord-344835-iivry1ou	175	16	with	with	IN
cord-344835-iivry1ou	175	17	mild	mild	JJ
cord-344835-iivry1ou	175	18	chronic	chronic	JJ
cord-344835-iivry1ou	175	19	obstructive	obstructive	JJ
cord-344835-iivry1ou	175	20	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	175	21	disease	disease	NN
cord-344835-iivry1ou	175	22	:	:	:
cord-344835-iivry1ou	175	23	results	result	NNS
cord-344835-iivry1ou	175	24	from	from	IN
cord-344835-iivry1ou	175	25	the	the	DT
cord-344835-iivry1ou	175	26	lung	lung	NNP
cord-344835-iivry1ou	175	27	health	health	NNP
cord-344835-iivry1ou	175	28	study	study	NNP
cord-344835-iivry1ou	175	29	Association	Association	NNP
cord-344835-iivry1ou	175	30	of	of	IN
cord-344835-iivry1ou	175	31	chronic	chronic	NNP
cord-344835-iivry1ou	175	32	mucus	mucus	NN
cord-344835-iivry1ou	175	33	hypersecretion	hypersecretion	NN
cord-344835-iivry1ou	175	34	with	with	IN
cord-344835-iivry1ou	175	35	FEV1	FEV1	NNP
cord-344835-iivry1ou	175	36	decline	decline	NN
cord-344835-iivry1ou	175	37	and	and	CC
cord-344835-iivry1ou	175	38	chronic	chronic	JJ
cord-344835-iivry1ou	175	39	obstructive	obstructive	JJ
cord-344835-iivry1ou	175	40	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	175	41	disease	disease	NN
cord-344835-iivry1ou	175	42	morbidity	morbidity	NN
cord-344835-iivry1ou	175	43	.	.	.
cord-344835-iivry1ou	176	1	Copenhagen	Copenhagen	NNP
cord-344835-iivry1ou	176	2	City	City	NNP
cord-344835-iivry1ou	176	3	Heart	Heart	NNP
cord-344835-iivry1ou	176	4	Study	Study	NNP
cord-344835-iivry1ou	176	5	Group	Group	NNP
cord-344835-iivry1ou	176	6	Standards	Standards	NNPS
cord-344835-iivry1ou	176	7	for	for	IN
cord-344835-iivry1ou	176	8	the	the	DT
cord-344835-iivry1ou	176	9	diagnosis	diagnosis	NN
cord-344835-iivry1ou	176	10	and	and	CC
cord-344835-iivry1ou	176	11	treatment	treatment	NN
cord-344835-iivry1ou	176	12	of	of	IN
cord-344835-iivry1ou	176	13	patients	patient	NNS
cord-344835-iivry1ou	176	14	with	with	IN
cord-344835-iivry1ou	176	15	COPD	COPD	NNP
cord-344835-iivry1ou	176	16	:	:	:
cord-344835-iivry1ou	176	17	a	a	DT
cord-344835-iivry1ou	176	18	summary	summary	NN
cord-344835-iivry1ou	176	19	of	of	IN
cord-344835-iivry1ou	176	20	the	the	DT
cord-344835-iivry1ou	176	21	ATS	ATS	NNP
cord-344835-iivry1ou	176	22	/	/	SYM
cord-344835-iivry1ou	176	23	ERS	ERS	NNP
cord-344835-iivry1ou	176	24	position	position	NN
cord-344835-iivry1ou	176	25	paper	paper	NN
cord-344835-iivry1ou	176	26	Chronic	Chronic	NNP
cord-344835-iivry1ou	176	27	obstructive	obstructive	JJ
cord-344835-iivry1ou	176	28	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	176	29	disease	disease	NN
cord-344835-iivry1ou	176	30	.	.	.
cord-344835-iivry1ou	177	1	6	6	LS
cord-344835-iivry1ou	177	2	:	:	:
cord-344835-iivry1ou	178	1	The	the	DT
cord-344835-iivry1ou	178	2	aetiology	aetiology	NN
cord-344835-iivry1ou	178	3	of	of	IN
cord-344835-iivry1ou	178	4	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	178	5	of	of	IN
cord-344835-iivry1ou	178	6	chronic	chronic	JJ
cord-344835-iivry1ou	178	7	obstructive	obstructive	JJ
cord-344835-iivry1ou	178	8	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	178	9	disease	disease	NN
cord-344835-iivry1ou	178	10	Exacerbations	Exacerbations	NNPS
cord-344835-iivry1ou	178	11	:	:	:
cord-344835-iivry1ou	178	12	etiology	etiology	NN
cord-344835-iivry1ou	178	13	and	and	CC
cord-344835-iivry1ou	178	14	pathophysiologic	pathophysiologic	NN
cord-344835-iivry1ou	178	15	mechanisms	mechanism	NNS
cord-344835-iivry1ou	179	1	The	the	DT
cord-344835-iivry1ou	179	2	role	role	NN
cord-344835-iivry1ou	179	3	of	of	IN
cord-344835-iivry1ou	179	4	bacteria	bacteria	NNS
cord-344835-iivry1ou	179	5	in	in	IN
cord-344835-iivry1ou	179	6	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	179	7	of	of	IN
cord-344835-iivry1ou	179	8	COPD	COPD	NNP
cord-344835-iivry1ou	179	9	.	.	.
cord-344835-iivry1ou	180	1	A	a	DT
cord-344835-iivry1ou	180	2	constructive	constructive	JJ
cord-344835-iivry1ou	180	3	view	view	NN
cord-344835-iivry1ou	181	1	Exacerbations	exacerbation	NNS
cord-344835-iivry1ou	181	2	of	of	IN
cord-344835-iivry1ou	181	3	chronic	chronic	JJ
cord-344835-iivry1ou	181	4	obstructive	obstructive	JJ
cord-344835-iivry1ou	181	5	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	181	6	disease	disease	NN
cord-344835-iivry1ou	181	7	:	:	:
cord-344835-iivry1ou	181	8	when	when	WRB
cord-344835-iivry1ou	181	9	are	be	VBP
cord-344835-iivry1ou	181	10	bacteria	bacteria	NNS
cord-344835-iivry1ou	181	11	important	important	JJ
cord-344835-iivry1ou	181	12	?	?	.
cord-344835-iivry1ou	182	1	Bacterial	bacterial	JJ
cord-344835-iivry1ou	182	2	infection	infection	NN
cord-344835-iivry1ou	182	3	and	and	CC
cord-344835-iivry1ou	182	4	the	the	DT
cord-344835-iivry1ou	182	5	pathogenesis	pathogenesis	NN
cord-344835-iivry1ou	182	6	of	of	IN
cord-344835-iivry1ou	182	7	COPD	COPD	NNP
cord-344835-iivry1ou	182	8	New	new	JJ
cord-344835-iivry1ou	182	9	strains	strain	NNS
cord-344835-iivry1ou	182	10	of	of	IN
cord-344835-iivry1ou	182	11	bacteria	bacteria	NNS
cord-344835-iivry1ou	182	12	and	and	CC
cord-344835-iivry1ou	182	13	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	182	14	of	of	IN
cord-344835-iivry1ou	182	15	chronic	chronic	JJ
cord-344835-iivry1ou	182	16	obstructive	obstructive	JJ
cord-344835-iivry1ou	182	17	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	182	18	disease	disease	NN
cord-344835-iivry1ou	182	19	Strain	strain	NN
cord-344835-iivry1ou	182	20	-	-	HYPH
cord-344835-iivry1ou	182	21	specific	specific	JJ
cord-344835-iivry1ou	182	22	immune	immune	JJ
cord-344835-iivry1ou	182	23	response	response	NN
cord-344835-iivry1ou	182	24	to	to	IN
cord-344835-iivry1ou	182	25	Haemophilus	haemophilus	JJ
cord-344835-iivry1ou	182	26	influenzae	influenzae	NN
cord-344835-iivry1ou	182	27	in	in	IN
cord-344835-iivry1ou	182	28	chronic	chronic	JJ
cord-344835-iivry1ou	182	29	obstructive	obstructive	JJ
cord-344835-iivry1ou	182	30	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	182	31	disease	disease	NN
cord-344835-iivry1ou	182	32	Haemophilus	haemophilus	NN
cord-344835-iivry1ou	182	33	influenzae	influenzae	NN
cord-344835-iivry1ou	182	34	from	from	IN
cord-344835-iivry1ou	182	35	patients	patient	NNS
cord-344835-iivry1ou	182	36	with	with	IN
cord-344835-iivry1ou	182	37	chronic	chronic	JJ
cord-344835-iivry1ou	182	38	obstructive	obstructive	JJ
cord-344835-iivry1ou	182	39	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	182	40	disease	disease	NN
cord-344835-iivry1ou	182	41	exacerbation	exacerbation	NN
cord-344835-iivry1ou	182	42	induce	induce	VB
cord-344835-iivry1ou	182	43	more	more	JJR
cord-344835-iivry1ou	182	44	inflammation	inflammation	NN
cord-344835-iivry1ou	182	45	than	than	IN
cord-344835-iivry1ou	182	46	colonizers	colonizer	NNS
cord-344835-iivry1ou	182	47	Pathogen	Pathogen	NNP
cord-344835-iivry1ou	182	48	recognition	recognition	NN
cord-344835-iivry1ou	182	49	with	with	IN
cord-344835-iivry1ou	182	50	Toll	toll	NN
cord-344835-iivry1ou	182	51	-	-	HYPH
cord-344835-iivry1ou	182	52	like	like	JJ
cord-344835-iivry1ou	182	53	receptors	receptor	NNS
cord-344835-iivry1ou	182	54	Airway	airway	VBP
cord-344835-iivry1ou	182	55	inflammation	inflammation	NN
cord-344835-iivry1ou	182	56	and	and	CC
cord-344835-iivry1ou	182	57	bronchial	bronchial	JJ
cord-344835-iivry1ou	182	58	microbial	microbial	JJ
cord-344835-iivry1ou	182	59	patterns	pattern	NNS
cord-344835-iivry1ou	182	60	in	in	IN
cord-344835-iivry1ou	182	61	patients	patient	NNS
cord-344835-iivry1ou	182	62	with	with	IN
cord-344835-iivry1ou	182	63	stable	stable	JJ
cord-344835-iivry1ou	182	64	chronic	chronic	JJ
cord-344835-iivry1ou	182	65	obstructive	obstructive	JJ
cord-344835-iivry1ou	182	66	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	182	67	disease	disease	NN
cord-344835-iivry1ou	182	68	Airway	Airway	NNP
cord-344835-iivry1ou	182	69	inflammation	inflammation	NN
cord-344835-iivry1ou	182	70	in	in	IN
cord-344835-iivry1ou	182	71	nonobstructive	nonobstructive	JJ
cord-344835-iivry1ou	182	72	and	and	CC
cord-344835-iivry1ou	182	73	obstructive	obstructive	JJ
cord-344835-iivry1ou	182	74	chronic	chronic	NN
cord-344835-iivry1ou	182	75	bronchitis	bronchitis	NN
cord-344835-iivry1ou	182	76	with	with	IN
cord-344835-iivry1ou	182	77	chronic	chronic	JJ
cord-344835-iivry1ou	182	78	haemophilus	haemophilus	NN
cord-344835-iivry1ou	182	79	influenzae	influenzae	NN
cord-344835-iivry1ou	182	80	airway	airway	NN
cord-344835-iivry1ou	182	81	infection	infection	NN
cord-344835-iivry1ou	182	82	.	.	.
cord-344835-iivry1ou	183	1	Comparison	comparison	NN
cord-344835-iivry1ou	183	2	with	with	IN
cord-344835-iivry1ou	183	3	noninfected	noninfected	JJ
cord-344835-iivry1ou	183	4	patients	patient	NNS
cord-344835-iivry1ou	183	5	with	with	IN
cord-344835-iivry1ou	183	6	chronic	chronic	JJ
cord-344835-iivry1ou	183	7	obstructive	obstructive	JJ
cord-344835-iivry1ou	183	8	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	183	9	disease	disease	NNP
cord-344835-iivry1ou	183	10	Association	Association	NNP
cord-344835-iivry1ou	183	11	between	between	IN
cord-344835-iivry1ou	183	12	airway	airway	NN
cord-344835-iivry1ou	183	13	bacterial	bacterial	JJ
cord-344835-iivry1ou	183	14	load	load	NN
cord-344835-iivry1ou	183	15	and	and	CC
cord-344835-iivry1ou	183	16	markers	marker	NNS
cord-344835-iivry1ou	183	17	of	of	IN
cord-344835-iivry1ou	183	18	airway	airway	JJ
cord-344835-iivry1ou	183	19	inflammation	inflammation	NN
cord-344835-iivry1ou	183	20	in	in	IN
cord-344835-iivry1ou	183	21	patients	patient	NNS
cord-344835-iivry1ou	183	22	with	with	IN
cord-344835-iivry1ou	183	23	stable	stable	JJ
cord-344835-iivry1ou	183	24	chronic	chronic	JJ
cord-344835-iivry1ou	183	25	bronchitis	bronchitis	NN
cord-344835-iivry1ou	183	26	Relationship	relationship	NN
cord-344835-iivry1ou	183	27	between	between	IN
cord-344835-iivry1ou	183	28	bacterial	bacterial	JJ
cord-344835-iivry1ou	183	29	colonisation	colonisation	NN
cord-344835-iivry1ou	183	30	and	and	CC
cord-344835-iivry1ou	183	31	the	the	DT
cord-344835-iivry1ou	183	32	frequency	frequency	NN
cord-344835-iivry1ou	183	33	,	,	,
cord-344835-iivry1ou	183	34	character	character	NN
cord-344835-iivry1ou	183	35	,	,	,
cord-344835-iivry1ou	183	36	and	and	CC
cord-344835-iivry1ou	183	37	severity	severity	NN
cord-344835-iivry1ou	183	38	of	of	IN
cord-344835-iivry1ou	183	39	COPD	COPD	NNP
cord-344835-iivry1ou	183	40	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	183	41	Relationships	relationship	NNS
cord-344835-iivry1ou	183	42	among	among	IN
cord-344835-iivry1ou	183	43	bacteria	bacteria	NNS
cord-344835-iivry1ou	183	44	,	,	,
cord-344835-iivry1ou	183	45	upper	upper	JJ
cord-344835-iivry1ou	183	46	airway	airway	NN
cord-344835-iivry1ou	183	47	,	,	,
cord-344835-iivry1ou	183	48	lower	low	JJR
cord-344835-iivry1ou	183	49	airway	airway	NN
cord-344835-iivry1ou	183	50	,	,	,
cord-344835-iivry1ou	183	51	and	and	CC
cord-344835-iivry1ou	183	52	systemic	systemic	JJ
cord-344835-iivry1ou	183	53	inflammation	inflammation	NN
cord-344835-iivry1ou	183	54	in	in	IN
cord-344835-iivry1ou	183	55	COPD	COPD	NNP
cord-344835-iivry1ou	184	1	Airway	airway	JJ
cord-344835-iivry1ou	184	2	inflammation	inflammation	NN
cord-344835-iivry1ou	184	3	and	and	CC
cord-344835-iivry1ou	184	4	etiology	etiology	NN
cord-344835-iivry1ou	184	5	of	of	IN
cord-344835-iivry1ou	184	6	acute	acute	JJ
cord-344835-iivry1ou	184	7	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	184	8	of	of	IN
cord-344835-iivry1ou	184	9	chronic	chronic	JJ
cord-344835-iivry1ou	184	10	bronchitis	bronchitis	NN
cord-344835-iivry1ou	184	11	Resolution	resolution	NN
cord-344835-iivry1ou	184	12	of	of	IN
cord-344835-iivry1ou	184	13	bronchial	bronchial	JJ
cord-344835-iivry1ou	184	14	inflammation	inflammation	NN
cord-344835-iivry1ou	184	15	is	be	VBZ
cord-344835-iivry1ou	184	16	related	relate	VBN
cord-344835-iivry1ou	184	17	to	to	IN
cord-344835-iivry1ou	184	18	bacterial	bacterial	JJ
cord-344835-iivry1ou	184	19	eradication	eradication	NN
cord-344835-iivry1ou	184	20	following	follow	VBG
cord-344835-iivry1ou	184	21	treatment	treatment	NN
cord-344835-iivry1ou	184	22	of	of	IN
cord-344835-iivry1ou	184	23	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	184	24	of	of	IN
cord-344835-iivry1ou	184	25	chronic	chronic	JJ
cord-344835-iivry1ou	184	26	bronchitis	bronchitis	NN
cord-344835-iivry1ou	184	27	Upper	Upper	NNP
cord-344835-iivry1ou	184	28	and	and	CC
cord-344835-iivry1ou	184	29	Lower	low	JJR
cord-344835-iivry1ou	184	30	Airway	airway	NN
cord-344835-iivry1ou	184	31	Inflammation	inflammation	NN
cord-344835-iivry1ou	184	32	at	at	IN
cord-344835-iivry1ou	184	33	Exacerbation	Exacerbation	NNP
cord-344835-iivry1ou	184	34	of	of	IN
cord-344835-iivry1ou	184	35	COPD	COPD	NNP
cord-344835-iivry1ou	184	36	Bronchial	bronchial	JJ
cord-344835-iivry1ou	184	37	inflammation	inflammation	NN
cord-344835-iivry1ou	184	38	in	in	IN
cord-344835-iivry1ou	184	39	acute	acute	JJ
cord-344835-iivry1ou	184	40	bacterial	bacterial	JJ
cord-344835-iivry1ou	184	41	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	184	42	of	of	IN
cord-344835-iivry1ou	184	43	chronic	chronic	JJ
cord-344835-iivry1ou	184	44	bronchitis	bronchitis	NN
cord-344835-iivry1ou	184	45	:	:	:
cord-344835-iivry1ou	184	46	the	the	DT
cord-344835-iivry1ou	184	47	role	role	NN
cord-344835-iivry1ou	184	48	of	of	IN
cord-344835-iivry1ou	184	49	leukotriene	leukotriene	NN
cord-344835-iivry1ou	184	50	B4	B4	NNP
cord-344835-iivry1ou	184	51	Changes	change	NNS
cord-344835-iivry1ou	184	52	in	in	IN
cord-344835-iivry1ou	184	53	bronchial	bronchial	JJ
cord-344835-iivry1ou	184	54	inflammation	inflammation	NN
cord-344835-iivry1ou	184	55	during	during	IN
cord-344835-iivry1ou	184	56	acute	acute	JJ
cord-344835-iivry1ou	184	57	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	184	58	of	of	IN
cord-344835-iivry1ou	184	59	chronic	chronic	JJ
cord-344835-iivry1ou	184	60	bronchitis	bronchitis	NN
cord-344835-iivry1ou	184	61	Role	role	NN
cord-344835-iivry1ou	184	62	of	of	IN
cord-344835-iivry1ou	184	63	infection	infection	NN
cord-344835-iivry1ou	184	64	in	in	IN
cord-344835-iivry1ou	184	65	chronic	chronic	JJ
cord-344835-iivry1ou	184	66	bronchitis	bronchitis	NN
cord-344835-iivry1ou	184	67	Infections	infection	NNS
cord-344835-iivry1ou	184	68	with	with	IN
cord-344835-iivry1ou	184	69	viruses	virus	NNS
cord-344835-iivry1ou	184	70	and	and	CC
cord-344835-iivry1ou	184	71	Mycoplasma	Mycoplasma	NNP
cord-344835-iivry1ou	184	72	pneumoniae	pneumoniae	NNS
cord-344835-iivry1ou	184	73	during	during	IN
cord-344835-iivry1ou	184	74	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	184	75	of	of	IN
cord-344835-iivry1ou	184	76	chronic	chronic	JJ
cord-344835-iivry1ou	184	77	bronchitis	bronchitis	NNP
cord-344835-iivry1ou	184	78	Association	Association	NNP
cord-344835-iivry1ou	184	79	of	of	IN
cord-344835-iivry1ou	184	80	viral	viral	JJ
cord-344835-iivry1ou	184	81	and	and	CC
cord-344835-iivry1ou	184	82	Mycoplasma	mycoplasma	NN
cord-344835-iivry1ou	184	83	pneumoniae	pneumoniae	NN
cord-344835-iivry1ou	184	84	infections	infection	NNS
cord-344835-iivry1ou	184	85	with	with	IN
cord-344835-iivry1ou	184	86	acute	acute	JJ
cord-344835-iivry1ou	184	87	respiratory	respiratory	JJ
cord-344835-iivry1ou	184	88	illness	illness	NN
cord-344835-iivry1ou	184	89	in	in	IN
cord-344835-iivry1ou	184	90	patients	patient	NNS
cord-344835-iivry1ou	184	91	with	with	IN
cord-344835-iivry1ou	184	92	chronic	chronic	JJ
cord-344835-iivry1ou	184	93	obstructive	obstructive	JJ
cord-344835-iivry1ou	184	94	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	184	95	diseases	disease	NNS
cord-344835-iivry1ou	184	96	Wedzicha	Wedzicha	NNP
cord-344835-iivry1ou	184	97	JA	JA	NNP
cord-344835-iivry1ou	184	98	:	:	:
cord-344835-iivry1ou	185	1	Respiratory	respiratory	JJ
cord-344835-iivry1ou	185	2	viruses	virus	NNS
cord-344835-iivry1ou	185	3	,	,	,
cord-344835-iivry1ou	185	4	symptoms	symptom	NNS
cord-344835-iivry1ou	185	5	,	,	,
cord-344835-iivry1ou	185	6	and	and	CC
cord-344835-iivry1ou	185	7	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	185	8	markers	marker	NNS
cord-344835-iivry1ou	185	9	in	in	IN
cord-344835-iivry1ou	185	10	acute	acute	JJ
cord-344835-iivry1ou	185	11	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	185	12	and	and	CC
cord-344835-iivry1ou	185	13	stable	stable	JJ
cord-344835-iivry1ou	185	14	chronic	chronic	JJ
cord-344835-iivry1ou	185	15	obstructive	obstructive	JJ
cord-344835-iivry1ou	185	16	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	185	17	disease	disease	NN
cord-344835-iivry1ou	185	18	Respiratory	respiratory	JJ
cord-344835-iivry1ou	185	19	viruses	virus	NNS
cord-344835-iivry1ou	185	20	in	in	IN
cord-344835-iivry1ou	185	21	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	185	22	of	of	IN
cord-344835-iivry1ou	185	23	chronic	chronic	JJ
cord-344835-iivry1ou	185	24	obstructive	obstructive	JJ
cord-344835-iivry1ou	185	25	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	185	26	disease	disease	NN
cord-344835-iivry1ou	185	27	requiring	require	VBG
cord-344835-iivry1ou	185	28	hospitalisation	hospitalisation	NN
cord-344835-iivry1ou	185	29	:	:	:
cord-344835-iivry1ou	185	30	a	a	DT
cord-344835-iivry1ou	185	31	case	case	NN
cord-344835-iivry1ou	185	32	-	-	HYPH
cord-344835-iivry1ou	185	33	control	control	NN
cord-344835-iivry1ou	185	34	study	study	NN
cord-344835-iivry1ou	185	35	Host	Host	NNP
cord-344835-iivry1ou	185	36	defense	defense	NN
cord-344835-iivry1ou	185	37	function	function	NN
cord-344835-iivry1ou	185	38	of	of	IN
cord-344835-iivry1ou	185	39	the	the	DT
cord-344835-iivry1ou	185	40	airway	airway	NN
cord-344835-iivry1ou	185	41	epithelium	epithelium	NN
cord-344835-iivry1ou	185	42	in	in	IN
cord-344835-iivry1ou	185	43	health	health	NN
cord-344835-iivry1ou	185	44	and	and	CC
cord-344835-iivry1ou	185	45	disease	disease	NN
cord-344835-iivry1ou	185	46	:	:	:
cord-344835-iivry1ou	185	47	clinical	clinical	JJ
cord-344835-iivry1ou	185	48	background	background	NN
cord-344835-iivry1ou	185	49	Viruses	virus	NNS
cord-344835-iivry1ou	185	50	,	,	,
cord-344835-iivry1ou	185	51	dendritic	dendritic	JJ
cord-344835-iivry1ou	185	52	cells	cell	NNS
cord-344835-iivry1ou	185	53	and	and	CC
cord-344835-iivry1ou	185	54	the	the	DT
cord-344835-iivry1ou	185	55	lung	lung	NN
cord-344835-iivry1ou	186	1	The	the	DT
cord-344835-iivry1ou	186	2	role	role	NN
cord-344835-iivry1ou	186	3	of	of	IN
cord-344835-iivry1ou	186	4	viral	viral	JJ
cord-344835-iivry1ou	186	5	infections	infection	NNS
cord-344835-iivry1ou	186	6	in	in	IN
cord-344835-iivry1ou	186	7	the	the	DT
cord-344835-iivry1ou	186	8	natural	natural	JJ
cord-344835-iivry1ou	186	9	history	history	NN
cord-344835-iivry1ou	186	10	of	of	IN
cord-344835-iivry1ou	186	11	asthma	asthma	NN
cord-344835-iivry1ou	186	12	Emphysematous	Emphysematous	NNP
cord-344835-iivry1ou	186	13	lung	lung	NN
cord-344835-iivry1ou	186	14	destruction	destruction	NN
cord-344835-iivry1ou	186	15	by	by	IN
cord-344835-iivry1ou	186	16	cigarette	cigarette	NN
cord-344835-iivry1ou	186	17	smoke	smoke	NN
cord-344835-iivry1ou	186	18	.	.	.
cord-344835-iivry1ou	187	1	The	the	DT
cord-344835-iivry1ou	187	2	effects	effect	NNS
cord-344835-iivry1ou	187	3	of	of	IN
cord-344835-iivry1ou	187	4	latent	latent	JJ
cord-344835-iivry1ou	187	5	adenoviral	adenoviral	JJ
cord-344835-iivry1ou	187	6	infection	infection	NN
cord-344835-iivry1ou	187	7	on	on	IN
cord-344835-iivry1ou	187	8	the	the	DT
cord-344835-iivry1ou	187	9	lung	lung	NN
cord-344835-iivry1ou	187	10	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	187	11	response	response	NN
cord-344835-iivry1ou	187	12	Amplification	amplification	NN
cord-344835-iivry1ou	187	13	of	of	IN
cord-344835-iivry1ou	187	14	inflammation	inflammation	NN
cord-344835-iivry1ou	187	15	in	in	IN
cord-344835-iivry1ou	187	16	emphysema	emphysema	NN
cord-344835-iivry1ou	187	17	and	and	CC
cord-344835-iivry1ou	187	18	its	-PRON-	PRP$
cord-344835-iivry1ou	187	19	association	association	NN
cord-344835-iivry1ou	187	20	with	with	IN
cord-344835-iivry1ou	187	21	latent	latent	JJ
cord-344835-iivry1ou	187	22	adenoviral	adenoviral	NNP
cord-344835-iivry1ou	187	23	infection	infection	NN
cord-344835-iivry1ou	187	24	Detection	Detection	NNP
cord-344835-iivry1ou	187	25	of	of	IN
cord-344835-iivry1ou	187	26	rhinovirus	rhinovirus	NN
cord-344835-iivry1ou	187	27	in	in	IN
cord-344835-iivry1ou	187	28	induced	induce	VBN
cord-344835-iivry1ou	187	29	sputum	sputum	NN
cord-344835-iivry1ou	187	30	at	at	IN
cord-344835-iivry1ou	187	31	exacerbation	exacerbation	NN
cord-344835-iivry1ou	187	32	of	of	IN
cord-344835-iivry1ou	187	33	chronic	chronic	JJ
cord-344835-iivry1ou	187	34	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	35	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	36	disease	disease	NN
cord-344835-iivry1ou	187	37	Infections	Infections	NNPS
cord-344835-iivry1ou	187	38	and	and	CC
cord-344835-iivry1ou	187	39	Airway	Airway	NNP
cord-344835-iivry1ou	187	40	Inflammation	inflammation	NN
cord-344835-iivry1ou	187	41	in	in	IN
cord-344835-iivry1ou	187	42	Chronic	Chronic	NNP
cord-344835-iivry1ou	187	43	Obstructive	obstructive	JJ
cord-344835-iivry1ou	187	44	Pulmonary	Pulmonary	NNP
cord-344835-iivry1ou	187	45	Disease	Disease	NNP
cord-344835-iivry1ou	187	46	Severe	Severe	NNP
cord-344835-iivry1ou	187	47	Exacerbations	Exacerbations	NNPS
cord-344835-iivry1ou	187	48	Airway	Airway	NNP
cord-344835-iivry1ou	187	49	inflammation	inflammation	NN
cord-344835-iivry1ou	187	50	during	during	IN
cord-344835-iivry1ou	187	51	stable	stable	JJ
cord-344835-iivry1ou	187	52	and	and	CC
cord-344835-iivry1ou	187	53	acutely	acutely	RB
cord-344835-iivry1ou	187	54	exacerbated	exacerbated	JJ
cord-344835-iivry1ou	187	55	chronic	chronic	JJ
cord-344835-iivry1ou	187	56	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	57	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	58	disease	disease	NN
cord-344835-iivry1ou	187	59	Soluble	Soluble	NNP
cord-344835-iivry1ou	187	60	interleukin-5	interleukin-5	NNP
cord-344835-iivry1ou	187	61	receptor	receptor	NN
cord-344835-iivry1ou	187	62	alpha	alpha	NN
cord-344835-iivry1ou	187	63	is	be	VBZ
cord-344835-iivry1ou	187	64	increased	increase	VBN
cord-344835-iivry1ou	187	65	in	in	IN
cord-344835-iivry1ou	187	66	acute	acute	JJ
cord-344835-iivry1ou	187	67	exacerbation	exacerbation	NN
cord-344835-iivry1ou	187	68	of	of	IN
cord-344835-iivry1ou	187	69	chronic	chronic	JJ
cord-344835-iivry1ou	187	70	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	71	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	72	disease	disease	NN
cord-344835-iivry1ou	187	73	Eotaxin	Eotaxin	NNP
cord-344835-iivry1ou	187	74	and	and	CC
cord-344835-iivry1ou	187	75	CCR3	CCR3	NNP
cord-344835-iivry1ou	187	76	are	be	VBP
cord-344835-iivry1ou	187	77	up	up	RB
cord-344835-iivry1ou	187	78	-	-	HYPH
cord-344835-iivry1ou	187	79	regulated	regulate	VBN
cord-344835-iivry1ou	187	80	in	in	IN
cord-344835-iivry1ou	187	81	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	82	of	of	IN
cord-344835-iivry1ou	187	83	chronic	chronic	JJ
cord-344835-iivry1ou	187	84	bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	85	Soluble	Soluble	NNP
cord-344835-iivry1ou	187	86	interleukin-5	interleukin-5	NNP
cord-344835-iivry1ou	187	87	receptor	receptor	NN
cord-344835-iivry1ou	187	88	alpha	alpha	NN
cord-344835-iivry1ou	187	89	is	be	VBZ
cord-344835-iivry1ou	187	90	increased	increase	VBN
cord-344835-iivry1ou	187	91	in	in	IN
cord-344835-iivry1ou	187	92	acute	acute	JJ
cord-344835-iivry1ou	187	93	exacerbation	exacerbation	NN
cord-344835-iivry1ou	187	94	of	of	IN
cord-344835-iivry1ou	187	95	chronic	chronic	JJ
cord-344835-iivry1ou	187	96	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	97	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	98	disease	disease	NN
cord-344835-iivry1ou	187	99	Eotaxin	Eotaxin	NNP
cord-344835-iivry1ou	187	100	and	and	CC
cord-344835-iivry1ou	187	101	CCR3	CCR3	NNP
cord-344835-iivry1ou	187	102	are	be	VBP
cord-344835-iivry1ou	187	103	up	up	RB
cord-344835-iivry1ou	187	104	-	-	HYPH
cord-344835-iivry1ou	187	105	regulated	regulate	VBN
cord-344835-iivry1ou	187	106	in	in	IN
cord-344835-iivry1ou	187	107	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	108	of	of	IN
cord-344835-iivry1ou	187	109	chronic	chronic	JJ
cord-344835-iivry1ou	187	110	bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	111	Airway	airway	NN
cord-344835-iivry1ou	187	112	inflammation	inflammation	NN
cord-344835-iivry1ou	187	113	during	during	IN
cord-344835-iivry1ou	187	114	stable	stable	JJ
cord-344835-iivry1ou	187	115	and	and	CC
cord-344835-iivry1ou	187	116	acutely	acutely	RB
cord-344835-iivry1ou	187	117	exacerbated	exacerbated	JJ
cord-344835-iivry1ou	187	118	chronic	chronic	JJ
cord-344835-iivry1ou	187	119	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	120	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	121	disease	disease	NN
cord-344835-iivry1ou	187	122	Airway	Airway	NNP
cord-344835-iivry1ou	187	123	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	187	124	in	in	IN
cord-344835-iivry1ou	187	125	chronic	chronic	JJ
cord-344835-iivry1ou	187	126	bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	127	during	during	IN
cord-344835-iivry1ou	187	128	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	129	Airway	Airway	NNP
cord-344835-iivry1ou	187	130	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	187	131	and	and	CC
cord-344835-iivry1ou	187	132	expression	expression	NN
cord-344835-iivry1ou	187	133	of	of	IN
cord-344835-iivry1ou	187	134	interleukin-5	interleukin-5	NNP
cord-344835-iivry1ou	187	135	protein	protein	NN
cord-344835-iivry1ou	187	136	in	in	IN
cord-344835-iivry1ou	187	137	asthma	asthma	NN
cord-344835-iivry1ou	187	138	and	and	CC
cord-344835-iivry1ou	187	139	in	in	IN
cord-344835-iivry1ou	187	140	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	141	of	of	IN
cord-344835-iivry1ou	187	142	chronic	chronic	JJ
cord-344835-iivry1ou	187	143	bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	144	Airway	airway	NN
cord-344835-iivry1ou	187	145	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	187	146	in	in	IN
cord-344835-iivry1ou	187	147	chronic	chronic	JJ
cord-344835-iivry1ou	187	148	bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	149	during	during	IN
cord-344835-iivry1ou	187	150	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	151	Exacerbations	Exacerbations	NNPS
cord-344835-iivry1ou	187	152	of	of	IN
cord-344835-iivry1ou	187	153	Bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	154	:	:	:
cord-344835-iivry1ou	187	155	bronchial	bronchial	JJ
cord-344835-iivry1ou	187	156	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	187	157	and	and	CC
cord-344835-iivry1ou	187	158	gene	gene	NN
cord-344835-iivry1ou	187	159	expression	expression	NN
cord-344835-iivry1ou	187	160	for	for	IN
cord-344835-iivry1ou	187	161	interleukin-4	interleukin-4	NNP
cord-344835-iivry1ou	187	162	,	,	,
cord-344835-iivry1ou	187	163	interleukin-5	interleukin-5	NNP
cord-344835-iivry1ou	187	164	,	,	,
cord-344835-iivry1ou	187	165	and	and	CC
cord-344835-iivry1ou	187	166	eosinophil	eosinophil	NN
cord-344835-iivry1ou	187	167	chemoattractants	chemoattractant	NNS
cord-344835-iivry1ou	187	168	New	new	JJ
cord-344835-iivry1ou	187	169	developments	development	NNS
cord-344835-iivry1ou	187	170	in	in	IN
cord-344835-iivry1ou	187	171	the	the	DT
cord-344835-iivry1ou	187	172	pathogenesis	pathogenesis	NN
cord-344835-iivry1ou	187	173	of	of	IN
cord-344835-iivry1ou	187	174	acute	acute	JJ
cord-344835-iivry1ou	187	175	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	176	of	of	IN
cord-344835-iivry1ou	187	177	chronic	chronic	JJ
cord-344835-iivry1ou	187	178	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	179	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	180	disease	disease	NN
cord-344835-iivry1ou	187	181	Chlamydia	Chlamydia	NNP
cord-344835-iivry1ou	187	182	pneumoniae	pneumoniae	NN
cord-344835-iivry1ou	187	183	infection	infection	NN
cord-344835-iivry1ou	187	184	in	in	IN
cord-344835-iivry1ou	187	185	acute	acute	JJ
cord-344835-iivry1ou	187	186	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	187	of	of	IN
cord-344835-iivry1ou	187	188	COPD	COPD	NNP
cord-344835-iivry1ou	187	189	Chlamydia	Chlamydia	NNP
cord-344835-iivry1ou	187	190	pneumoniae	pneumoniae	NN
cord-344835-iivry1ou	187	191	,	,	,
cord-344835-iivry1ou	187	192	strain	strain	VB
cord-344835-iivry1ou	187	193	TWAR	TWAR	NNP
cord-344835-iivry1ou	187	194	,	,	,
cord-344835-iivry1ou	187	195	infection	infection	NN
cord-344835-iivry1ou	187	196	in	in	IN
cord-344835-iivry1ou	187	197	patients	patient	NNS
cord-344835-iivry1ou	187	198	with	with	IN
cord-344835-iivry1ou	187	199	chronic	chronic	JJ
cord-344835-iivry1ou	187	200	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	201	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	202	disease	disease	NN
cord-344835-iivry1ou	187	203	Sputum	Sputum	NNP
cord-344835-iivry1ou	187	204	and	and	CC
cord-344835-iivry1ou	187	205	plasma	plasma	NN
cord-344835-iivry1ou	187	206	endothelin-1	endothelin-1	NNP
cord-344835-iivry1ou	187	207	levels	level	NNS
cord-344835-iivry1ou	187	208	in	in	IN
cord-344835-iivry1ou	187	209	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	187	210	of	of	IN
cord-344835-iivry1ou	187	211	chronic	chronic	JJ
cord-344835-iivry1ou	187	212	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	213	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	214	disease	disease	NN
cord-344835-iivry1ou	187	215	Chlamydia	Chlamydia	NNP
cord-344835-iivry1ou	187	216	pneumoniae	pneumoniae	NN
cord-344835-iivry1ou	187	217	and	and	CC
cord-344835-iivry1ou	187	218	chronic	chronic	JJ
cord-344835-iivry1ou	187	219	bronchitis	bronchitis	NN
cord-344835-iivry1ou	187	220	:	:	:
cord-344835-iivry1ou	187	221	association	association	NN
cord-344835-iivry1ou	187	222	with	with	IN
cord-344835-iivry1ou	187	223	severity	severity	NN
cord-344835-iivry1ou	187	224	and	and	CC
cord-344835-iivry1ou	187	225	bacterial	bacterial	JJ
cord-344835-iivry1ou	187	226	clearance	clearance	NN
cord-344835-iivry1ou	187	227	following	follow	VBG
cord-344835-iivry1ou	187	228	treatment	treatment	NN
cord-344835-iivry1ou	187	229	Chlamydia	Chlamydia	NNP
cord-344835-iivry1ou	187	230	pneumoniae	pneumoniae	NN
cord-344835-iivry1ou	187	231	infection	infection	NN
cord-344835-iivry1ou	187	232	and	and	CC
cord-344835-iivry1ou	187	233	its	-PRON-	PRP$
cord-344835-iivry1ou	187	234	role	role	NN
cord-344835-iivry1ou	187	235	in	in	IN
cord-344835-iivry1ou	187	236	asthma	asthma	NN
cord-344835-iivry1ou	187	237	and	and	CC
cord-344835-iivry1ou	187	238	chronic	chronic	JJ
cord-344835-iivry1ou	187	239	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	240	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	241	disease	disease	NN
cord-344835-iivry1ou	187	242	Air	Air	NNP
cord-344835-iivry1ou	187	243	pollution	pollution	NN
cord-344835-iivry1ou	187	244	and	and	CC
cord-344835-iivry1ou	187	245	emergency	emergency	NN
cord-344835-iivry1ou	187	246	room	room	NN
cord-344835-iivry1ou	187	247	admissions	admission	NNS
cord-344835-iivry1ou	187	248	for	for	IN
cord-344835-iivry1ou	187	249	chronic	chronic	JJ
cord-344835-iivry1ou	187	250	obstructive	obstructive	JJ
cord-344835-iivry1ou	187	251	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	187	252	disease	disease	NN
cord-344835-iivry1ou	187	253	:	:	:
cord-344835-iivry1ou	188	1	a	a	DT
cord-344835-iivry1ou	188	2	5-year	5-year	CD
cord-344835-iivry1ou	188	3	study	study	NN
cord-344835-iivry1ou	188	4	Diesel	diesel	NN
cord-344835-iivry1ou	188	5	exhaust	exhaust	NN
cord-344835-iivry1ou	188	6	particles	particle	NNS
cord-344835-iivry1ou	188	7	stimulate	stimulate	VBP
cord-344835-iivry1ou	188	8	human	human	JJ
cord-344835-iivry1ou	188	9	airway	airway	NN
cord-344835-iivry1ou	188	10	epithelial	epithelial	JJ
cord-344835-iivry1ou	188	11	cells	cell	NNS
cord-344835-iivry1ou	188	12	to	to	TO
cord-344835-iivry1ou	188	13	produce	produce	VB
cord-344835-iivry1ou	188	14	cytokines	cytokine	NNS
cord-344835-iivry1ou	188	15	relevant	relevant	JJ
cord-344835-iivry1ou	188	16	to	to	IN
cord-344835-iivry1ou	188	17	airway	airway	JJ
cord-344835-iivry1ou	188	18	inflammation	inflammation	NN
cord-344835-iivry1ou	188	19	in	in	IN
cord-344835-iivry1ou	188	20	vitro	vitro	FW
cord-344835-iivry1ou	188	21	Bronchoalveolar	Bronchoalveolar	NNP
cord-344835-iivry1ou	188	22	inflammation	inflammation	NN
cord-344835-iivry1ou	188	23	after	after	IN
cord-344835-iivry1ou	188	24	exposure	exposure	NN
cord-344835-iivry1ou	188	25	to	to	IN
cord-344835-iivry1ou	188	26	diesel	diesel	NN
cord-344835-iivry1ou	188	27	exhaust	exhaust	NN
cord-344835-iivry1ou	188	28	:	:	:
cord-344835-iivry1ou	188	29	comparison	comparison	NN
cord-344835-iivry1ou	188	30	between	between	IN
cord-344835-iivry1ou	188	31	unfiltered	unfiltered	JJ
cord-344835-iivry1ou	188	32	and	and	CC
cord-344835-iivry1ou	188	33	particle	particle	NN
cord-344835-iivry1ou	188	34	trap	trap	NN
cord-344835-iivry1ou	188	35	filtered	filter	VBN
cord-344835-iivry1ou	188	36	exhaust	exhaust	NN
cord-344835-iivry1ou	188	37	Particulate	particulate	NN
cord-344835-iivry1ou	188	38	air	air	NN
cord-344835-iivry1ou	188	39	pollution	pollution	NN
cord-344835-iivry1ou	188	40	and	and	CC
cord-344835-iivry1ou	188	41	acute	acute	JJ
cord-344835-iivry1ou	188	42	health	health	NN
cord-344835-iivry1ou	188	43	effects	effect	NNS
cord-344835-iivry1ou	188	44	Reactive	reactive	JJ
cord-344835-iivry1ou	188	45	oxygen	oxygen	NN
cord-344835-iivry1ou	188	46	species	specie	NNS
cord-344835-iivry1ou	188	47	in	in	IN
cord-344835-iivry1ou	188	48	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	188	49	inflammation	inflammation	NN
cord-344835-iivry1ou	188	50	by	by	IN
cord-344835-iivry1ou	188	51	ambient	ambient	JJ
cord-344835-iivry1ou	188	52	particulates	particulate	NNS
cord-344835-iivry1ou	188	53	Exacerbations	Exacerbations	NNPS
cord-344835-iivry1ou	188	54	of	of	IN
cord-344835-iivry1ou	188	55	COPD	COPD	NNP
cord-344835-iivry1ou	188	56	:	:	:
cord-344835-iivry1ou	188	57	environmental	environmental	JJ
cord-344835-iivry1ou	188	58	mechanisms	mechanism	NNS
cord-344835-iivry1ou	188	59	Systemic	systemic	JJ
cord-344835-iivry1ou	188	60	oxidative	oxidative	JJ
cord-344835-iivry1ou	188	61	stress	stress	NN
cord-344835-iivry1ou	188	62	in	in	IN
cord-344835-iivry1ou	188	63	asthma	asthma	NN
cord-344835-iivry1ou	188	64	,	,	,
cord-344835-iivry1ou	188	65	COPD	COPD	NNP
cord-344835-iivry1ou	188	66	,	,	,
cord-344835-iivry1ou	188	67	and	and	CC
cord-344835-iivry1ou	188	68	smokers	smoker	NNS
cord-344835-iivry1ou	189	1	Oxidative	oxidative	JJ
cord-344835-iivry1ou	189	2	stress	stress	NN
cord-344835-iivry1ou	189	3	and	and	CC
cord-344835-iivry1ou	189	4	airway	airway	NN
cord-344835-iivry1ou	189	5	inflammation	inflammation	NN
cord-344835-iivry1ou	189	6	in	in	IN
cord-344835-iivry1ou	189	7	severe	severe	JJ
cord-344835-iivry1ou	189	8	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	189	9	of	of	IN
cord-344835-iivry1ou	189	10	COPD	COPD	NNP
cord-344835-iivry1ou	189	11	Increased	increase	VBN
cord-344835-iivry1ou	189	12	leukotriene	leukotriene	NN
cord-344835-iivry1ou	189	13	B4	B4	NNP
cord-344835-iivry1ou	189	14	and	and	CC
cord-344835-iivry1ou	190	1	8-isoprostane	8-isoprostane	CD
cord-344835-iivry1ou	190	2	in	in	IN
cord-344835-iivry1ou	190	3	exhaled	exhale	VBN
cord-344835-iivry1ou	190	4	breath	breath	NN
cord-344835-iivry1ou	190	5	condensate	condensate	NN
cord-344835-iivry1ou	190	6	of	of	IN
cord-344835-iivry1ou	190	7	patients	patient	NNS
cord-344835-iivry1ou	190	8	with	with	IN
cord-344835-iivry1ou	190	9	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	190	10	of	of	IN
cord-344835-iivry1ou	190	11	COPD	COPD	NNP
cord-344835-iivry1ou	190	12	Siafakas	Siafakas	NNP
cord-344835-iivry1ou	190	13	NM	NM	NNP
cord-344835-iivry1ou	190	14	:	:	:
cord-344835-iivry1ou	190	15	Nitrosative	nitrosative	JJ
cord-344835-iivry1ou	190	16	stress	stress	NN
cord-344835-iivry1ou	190	17	,	,	,
cord-344835-iivry1ou	190	18	heme	heme	NN
cord-344835-iivry1ou	190	19	oxygenase-1	oxygenase-1	NNP
cord-344835-iivry1ou	190	20	expression	expression	NN
cord-344835-iivry1ou	190	21	and	and	CC
cord-344835-iivry1ou	190	22	airway	airway	NN
cord-344835-iivry1ou	190	23	inflammation	inflammation	NN
cord-344835-iivry1ou	190	24	during	during	IN
cord-344835-iivry1ou	190	25	severe	severe	JJ
cord-344835-iivry1ou	190	26	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	190	27	of	of	IN
cord-344835-iivry1ou	190	28	COPD	COPD	NNP
cord-344835-iivry1ou	190	29	Role	role	NN
cord-344835-iivry1ou	190	30	of	of	IN
cord-344835-iivry1ou	190	31	transcription	transcription	NN
cord-344835-iivry1ou	190	32	factors	factor	NNS
cord-344835-iivry1ou	190	33	in	in	IN
cord-344835-iivry1ou	190	34	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	190	35	lung	lung	NN
cord-344835-iivry1ou	190	36	diseases	disease	NNS
cord-344835-iivry1ou	190	37	NF	NF	NNP
cord-344835-iivry1ou	190	38	-	-	HYPH
cord-344835-iivry1ou	190	39	kB	kb	CD
cord-344835-iivry1ou	190	40	activation	activation	NN
cord-344835-iivry1ou	190	41	in	in	IN
cord-344835-iivry1ou	190	42	airway	airway	NNP
cord-344835-iivry1ou	190	43	leucocytes	leucocyte	NNS
cord-344835-iivry1ou	190	44	in	in	IN
cord-344835-iivry1ou	190	45	COPD	COPD	NNP
cord-344835-iivry1ou	190	46	patients	patient	NNS
cord-344835-iivry1ou	190	47	Nuclear	nuclear	JJ
cord-344835-iivry1ou	190	48	localisation	localisation	NN
cord-344835-iivry1ou	190	49	of	of	IN
cord-344835-iivry1ou	190	50	p65	p65	NN
cord-344835-iivry1ou	190	51	in	in	IN
cord-344835-iivry1ou	190	52	sputum	sputum	NN
cord-344835-iivry1ou	190	53	macrophages	macrophage	NNS
cord-344835-iivry1ou	190	54	but	but	CC
cord-344835-iivry1ou	190	55	not	not	RB
cord-344835-iivry1ou	190	56	in	in	IN
cord-344835-iivry1ou	190	57	sputum	sputum	JJ
cord-344835-iivry1ou	190	58	neutrophils	neutrophil	NNS
cord-344835-iivry1ou	190	59	during	during	IN
cord-344835-iivry1ou	190	60	COPD	COPD	NNP
cord-344835-iivry1ou	190	61	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	190	62	.	.	.
cord-344835-iivry1ou	191	1	Thorax	Thorax	NNP
cord-344835-iivry1ou	191	2	Oxidant	Oxidant	NNP
cord-344835-iivry1ou	191	3	stress	stress	NN
cord-344835-iivry1ou	191	4	regulation	regulation	NN
cord-344835-iivry1ou	191	5	of	of	IN
cord-344835-iivry1ou	191	6	IL-8	IL-8	NNP
cord-344835-iivry1ou	191	7	and	and	CC
cord-344835-iivry1ou	191	8	ICAM-1	icam-1	NN
cord-344835-iivry1ou	191	9	gene	gene	NN
cord-344835-iivry1ou	191	10	expression	expression	NN
cord-344835-iivry1ou	191	11	:	:	:
cord-344835-iivry1ou	191	12	differential	differential	JJ
cord-344835-iivry1ou	191	13	activation	activation	NN
cord-344835-iivry1ou	191	14	and	and	CC
cord-344835-iivry1ou	191	15	binding	binding	NN
cord-344835-iivry1ou	191	16	of	of	IN
cord-344835-iivry1ou	191	17	the	the	DT
cord-344835-iivry1ou	191	18	transcription	transcription	NN
cord-344835-iivry1ou	191	19	factors	factor	NNS
cord-344835-iivry1ou	191	20	AP-1	AP-1	NNP
cord-344835-iivry1ou	191	21	and	and	CC
cord-344835-iivry1ou	191	22	NF	NF	NNP
cord-344835-iivry1ou	191	23	-	-	HYPH
cord-344835-iivry1ou	191	24	kappaB	kappaB	NNP
cord-344835-iivry1ou	191	25	(	(	-LRB-
cord-344835-iivry1ou	191	26	Review	Review	NNP
cord-344835-iivry1ou	191	27	)	)	-RRB-
cord-344835-iivry1ou	191	28	Pathophysiology	pathophysiology	NN
cord-344835-iivry1ou	191	29	of	of	IN
cord-344835-iivry1ou	191	30	airflow	airflow	NN
cord-344835-iivry1ou	191	31	limitation	limitation	NN
cord-344835-iivry1ou	191	32	in	in	IN
cord-344835-iivry1ou	191	33	chronic	chronic	JJ
cord-344835-iivry1ou	191	34	obstructive	obstructive	JJ
cord-344835-iivry1ou	191	35	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	191	36	disease	disease	NN
cord-344835-iivry1ou	191	37	Inflammatory	inflammatory	JJ
cord-344835-iivry1ou	191	38	cell	cell	NN
cord-344835-iivry1ou	191	39	profiles	profile	NNS
cord-344835-iivry1ou	191	40	and	and	CC
cord-344835-iivry1ou	191	41	T	t	NN
cord-344835-iivry1ou	191	42	-	-	HYPH
cord-344835-iivry1ou	191	43	lymphocyte	lymphocyte	NN
cord-344835-iivry1ou	191	44	subsets	subset	NNS
cord-344835-iivry1ou	191	45	in	in	IN
cord-344835-iivry1ou	191	46	chronic	chronic	JJ
cord-344835-iivry1ou	191	47	obstructive	obstructive	JJ
cord-344835-iivry1ou	191	48	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	191	49	disease	disease	NN
cord-344835-iivry1ou	191	50	and	and	CC
cord-344835-iivry1ou	191	51	severe	severe	JJ
cord-344835-iivry1ou	191	52	persistent	persistent	JJ
cord-344835-iivry1ou	191	53	asthma	asthma	NN
cord-344835-iivry1ou	191	54	Increased	increase	VBN
cord-344835-iivry1ou	191	55	expression	expression	NN
cord-344835-iivry1ou	191	56	of	of	IN
cord-344835-iivry1ou	191	57	the	the	DT
cord-344835-iivry1ou	191	58	chemokine	chemokine	NN
cord-344835-iivry1ou	191	59	receptor	receptor	NN
cord-344835-iivry1ou	191	60	CXCR3	cxcr3	NN
cord-344835-iivry1ou	191	61	and	and	CC
cord-344835-iivry1ou	191	62	its	-PRON-	PRP$
cord-344835-iivry1ou	191	63	ligand	ligand	NN
cord-344835-iivry1ou	191	64	CXCL10	CXCL10	NNP
cord-344835-iivry1ou	191	65	in	in	IN
cord-344835-iivry1ou	191	66	peripheral	peripheral	JJ
cord-344835-iivry1ou	191	67	airways	airway	NNS
cord-344835-iivry1ou	191	68	of	of	IN
cord-344835-iivry1ou	191	69	smokers	smoker	NNS
cord-344835-iivry1ou	191	70	with	with	IN
cord-344835-iivry1ou	191	71	chronic	chronic	JJ
cord-344835-iivry1ou	191	72	obstructive	obstructive	JJ
cord-344835-iivry1ou	191	73	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	191	74	disease	disease	NN
cord-344835-iivry1ou	191	75	Inflammation	inflammation	NN
cord-344835-iivry1ou	191	76	in	in	IN
cord-344835-iivry1ou	191	77	bronchial	bronchial	JJ
cord-344835-iivry1ou	191	78	biopsies	biopsy	NNS
cord-344835-iivry1ou	191	79	of	of	IN
cord-344835-iivry1ou	191	80	subjects	subject	NNS
cord-344835-iivry1ou	191	81	with	with	IN
cord-344835-iivry1ou	191	82	chronic	chronic	JJ
cord-344835-iivry1ou	191	83	bronchitis	bronchitis	NN
cord-344835-iivry1ou	191	84	:	:	:
cord-344835-iivry1ou	191	85	inverse	inverse	JJ
cord-344835-iivry1ou	191	86	relationship	relationship	NN
cord-344835-iivry1ou	191	87	of	of	IN
cord-344835-iivry1ou	191	88	CD8	CD8	NNP
cord-344835-iivry1ou	191	89	+	+	CC
cord-344835-iivry1ou	191	90	T	T	NNP
cord-344835-iivry1ou	191	91	lymphocytes	lymphocyte	NNS
cord-344835-iivry1ou	191	92	with	with	IN
cord-344835-iivry1ou	191	93	FEV1	FEV1	NNP
cord-344835-iivry1ou	191	94	An	an	DT
cord-344835-iivry1ou	191	95	immune	immune	JJ
cord-344835-iivry1ou	191	96	basis	basis	NN
cord-344835-iivry1ou	191	97	for	for	IN
cord-344835-iivry1ou	191	98	lung	lung	NN
cord-344835-iivry1ou	191	99	parenchymal	parenchymal	NN
cord-344835-iivry1ou	191	100	destruction	destruction	NN
cord-344835-iivry1ou	191	101	in	in	IN
cord-344835-iivry1ou	191	102	chronic	chronic	JJ
cord-344835-iivry1ou	191	103	obstructive	obstructive	JJ
cord-344835-iivry1ou	191	104	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	191	105	disease	disease	NN
cord-344835-iivry1ou	191	106	and	and	CC
cord-344835-iivry1ou	191	107	emphysema	emphysema	NN
cord-344835-iivry1ou	191	108	Perforin	Perforin	NNP
cord-344835-iivry1ou	191	109	expression	expression	NN
cord-344835-iivry1ou	191	110	and	and	CC
cord-344835-iivry1ou	191	111	cytotoxic	cytotoxic	JJ
cord-344835-iivry1ou	191	112	activity	activity	NN
cord-344835-iivry1ou	191	113	of	of	IN
cord-344835-iivry1ou	191	114	sputum	sputum	NN
cord-344835-iivry1ou	191	115	CD8	CD8	NNS
cord-344835-iivry1ou	191	116	+	+	CC
cord-344835-iivry1ou	191	117	lymphocytes	lymphocyte	NNS
cord-344835-iivry1ou	191	118	in	in	IN
cord-344835-iivry1ou	191	119	patients	patient	NNS
cord-344835-iivry1ou	191	120	with	with	IN
cord-344835-iivry1ou	191	121	COPD	COPD	NNP
cord-344835-iivry1ou	191	122	Changes	change	NNS
cord-344835-iivry1ou	191	123	in	in	IN
cord-344835-iivry1ou	191	124	sputum	sputum	NN
cord-344835-iivry1ou	191	125	T	t	NN
cord-344835-iivry1ou	191	126	-	-	HYPH
cord-344835-iivry1ou	191	127	lymphocyte	lymphocyte	NN
cord-344835-iivry1ou	191	128	subpopulations	subpopulation	NNS
cord-344835-iivry1ou	191	129	at	at	IN
cord-344835-iivry1ou	191	130	the	the	DT
cord-344835-iivry1ou	191	131	onset	onset	NN
cord-344835-iivry1ou	191	132	of	of	IN
cord-344835-iivry1ou	191	133	severe	severe	JJ
cord-344835-iivry1ou	191	134	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	191	135	of	of	IN
cord-344835-iivry1ou	191	136	chronic	chronic	JJ
cord-344835-iivry1ou	191	137	obstructive	obstructive	JJ
cord-344835-iivry1ou	191	138	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	191	139	disease	disease	NN
cord-344835-iivry1ou	191	140	Virus	virus	NN
cord-344835-iivry1ou	191	141	-	-	HYPH
cord-344835-iivry1ou	191	142	specific	specific	JJ
cord-344835-iivry1ou	191	143	CD8(+	CD8(+	NNS
cord-344835-iivry1ou	191	144	)	)	-RRB-
cord-344835-iivry1ou	191	145	T	t	NN
cord-344835-iivry1ou	191	146	cells	cell	NNS
cord-344835-iivry1ou	191	147	with	with	IN
cord-344835-iivry1ou	191	148	type	type	NN
cord-344835-iivry1ou	191	149	1	1	CD
cord-344835-iivry1ou	191	150	or	or	CC
cord-344835-iivry1ou	191	151	type	type	NN
cord-344835-iivry1ou	191	152	2	2	CD
cord-344835-iivry1ou	191	153	cytokine	cytokine	NN
cord-344835-iivry1ou	191	154	profile	profile	NN
cord-344835-iivry1ou	191	155	are	be	VBP
cord-344835-iivry1ou	191	156	related	relate	VBN
cord-344835-iivry1ou	191	157	to	to	IN
cord-344835-iivry1ou	191	158	different	different	JJ
cord-344835-iivry1ou	191	159	disease	disease	NN
cord-344835-iivry1ou	191	160	activity	activity	NN
cord-344835-iivry1ou	191	161	in	in	IN
cord-344835-iivry1ou	191	162	chronic	chronic	JJ
cord-344835-iivry1ou	191	163	hepatitis	hepatitis	NN
cord-344835-iivry1ou	191	164	C	c	NN
cord-344835-iivry1ou	191	165	virus	virus	NN
cord-344835-iivry1ou	191	166	infection	infection	NN
cord-344835-iivry1ou	191	167	CD8(+	cd8(+	CD
cord-344835-iivry1ou	191	168	)	)	-RRB-
cord-344835-iivry1ou	192	1	T	t	NN
cord-344835-iivry1ou	192	2	cells	cell	NNS
cord-344835-iivry1ou	192	3	secreting	secrete	VBG
cord-344835-iivry1ou	192	4	type	type	NN
cord-344835-iivry1ou	192	5	2	2	CD
cord-344835-iivry1ou	192	6	lymphokines	lymphokine	NNS
cord-344835-iivry1ou	192	7	are	be	VBP
cord-344835-iivry1ou	192	8	defective	defective	JJ
cord-344835-iivry1ou	192	9	in	in	IN
cord-344835-iivry1ou	192	10	protection	protection	NN
cord-344835-iivry1ou	192	11	against	against	IN
cord-344835-iivry1ou	192	12	viral	viral	JJ
cord-344835-iivry1ou	192	13	infection	infection	NN
cord-344835-iivry1ou	192	14	Immune	immune	JJ
cord-344835-iivry1ou	192	15	regulation	regulation	NN
cord-344835-iivry1ou	192	16	:	:	:
cord-344835-iivry1ou	192	17	a	a	DT
cord-344835-iivry1ou	192	18	new	new	JJ
cord-344835-iivry1ou	192	19	role	role	NN
cord-344835-iivry1ou	192	20	for	for	IN
cord-344835-iivry1ou	192	21	the	the	DT
cord-344835-iivry1ou	192	22	CD8	CD8	NNP
cord-344835-iivry1ou	192	23	+	+	CC
cord-344835-iivry1ou	192	24	T	T	NNP
cord-344835-iivry1ou	192	25	cell	cell	NN
cord-344835-iivry1ou	192	26	.	.	.
cord-344835-iivry1ou	193	1	Immunol	Immunol	NNP
cord-344835-iivry1ou	194	1	Today	today	NN
cord-344835-iivry1ou	195	1	The	the	DT
cord-344835-iivry1ou	195	2	functional	functional	JJ
cord-344835-iivry1ou	195	3	role	role	NN
cord-344835-iivry1ou	195	4	of	of	IN
cord-344835-iivry1ou	195	5	CD8	CD8	NNP
cord-344835-iivry1ou	195	6	+	+	CC
cord-344835-iivry1ou	195	7	T	T	NNP
cord-344835-iivry1ou	195	8	helper	helper	NN
cord-344835-iivry1ou	195	9	type	type	NN
cord-344835-iivry1ou	195	10	2	2	CD
cord-344835-iivry1ou	195	11	cells	cell	NNS
cord-344835-iivry1ou	195	12	Relation	relation	NN
cord-344835-iivry1ou	195	13	of	of	IN
cord-344835-iivry1ou	195	14	sputum	sputum	JJ
cord-344835-iivry1ou	195	15	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	195	16	markers	marker	NNS
cord-344835-iivry1ou	195	17	to	to	IN
cord-344835-iivry1ou	195	18	symptoms	symptom	NNS
cord-344835-iivry1ou	195	19	and	and	CC
cord-344835-iivry1ou	195	20	lung	lung	NN
cord-344835-iivry1ou	195	21	function	function	NN
cord-344835-iivry1ou	195	22	changes	change	NNS
cord-344835-iivry1ou	195	23	in	in	IN
cord-344835-iivry1ou	195	24	COPD	COPD	NNP
cord-344835-iivry1ou	195	25	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	195	26	Airway	airway	NN
cord-344835-iivry1ou	195	27	and	and	CC
cord-344835-iivry1ou	195	28	systemic	systemic	JJ
cord-344835-iivry1ou	195	29	inflammation	inflammation	NN
cord-344835-iivry1ou	195	30	and	and	CC
cord-344835-iivry1ou	195	31	decline	decline	NN
cord-344835-iivry1ou	195	32	in	in	IN
cord-344835-iivry1ou	195	33	lung	lung	NN
cord-344835-iivry1ou	195	34	function	function	NN
cord-344835-iivry1ou	195	35	in	in	IN
cord-344835-iivry1ou	195	36	patients	patient	NNS
cord-344835-iivry1ou	195	37	with	with	IN
cord-344835-iivry1ou	195	38	COPD	COPD	NNP
cord-344835-iivry1ou	195	39	Relationship	Relationship	NNP
cord-344835-iivry1ou	195	40	between	between	IN
cord-344835-iivry1ou	195	41	airway	airway	JJ
cord-344835-iivry1ou	195	42	inflammation	inflammation	NN
cord-344835-iivry1ou	195	43	and	and	CC
cord-344835-iivry1ou	195	44	the	the	DT
cord-344835-iivry1ou	195	45	frequency	frequency	NN
cord-344835-iivry1ou	195	46	of	of	IN
cord-344835-iivry1ou	195	47	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	195	48	in	in	IN
cord-344835-iivry1ou	195	49	patients	patient	NNS
cord-344835-iivry1ou	195	50	with	with	IN
cord-344835-iivry1ou	195	51	smoking	smoking	NN
cord-344835-iivry1ou	195	52	related	relate	VBN
cord-344835-iivry1ou	195	53	COPD	COPD	NNP
cord-344835-iivry1ou	195	54	Bronchiectasis	Bronchiectasis	NNP
cord-344835-iivry1ou	195	55	,	,	,
cord-344835-iivry1ou	195	56	exacerbation	exacerbation	NN
cord-344835-iivry1ou	195	57	indices	index	NNS
cord-344835-iivry1ou	195	58	,	,	,
cord-344835-iivry1ou	195	59	and	and	CC
cord-344835-iivry1ou	195	60	inflammation	inflammation	NN
cord-344835-iivry1ou	195	61	in	in	IN
cord-344835-iivry1ou	195	62	chronic	chronic	JJ
cord-344835-iivry1ou	195	63	obstructive	obstructive	JJ
cord-344835-iivry1ou	195	64	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	195	65	disease	disease	NN
cord-344835-iivry1ou	195	66	Respiratory	respiratory	JJ
cord-344835-iivry1ou	195	67	failure	failure	NN
cord-344835-iivry1ou	195	68	in	in	IN
cord-344835-iivry1ou	195	69	chronic	chronic	JJ
cord-344835-iivry1ou	195	70	obstructive	obstructive	JJ
cord-344835-iivry1ou	195	71	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	195	72	disease	disease	NN
cord-344835-iivry1ou	195	73	Mediators	Mediators	NNPS
cord-344835-iivry1ou	195	74	of	of	IN
cord-344835-iivry1ou	195	75	chronic	chronic	JJ
cord-344835-iivry1ou	195	76	obstructive	obstructive	JJ
cord-344835-iivry1ou	195	77	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	195	78	disease	disease	NN
cord-344835-iivry1ou	195	79	Inflammation	inflammation	NN
cord-344835-iivry1ou	195	80	--	--	:
cord-344835-iivry1ou	195	81	role	role	NN
cord-344835-iivry1ou	195	82	of	of	IN
cord-344835-iivry1ou	195	83	the	the	DT
cord-344835-iivry1ou	195	84	neutrophil	neutrophil	NN
cord-344835-iivry1ou	195	85	and	and	CC
cord-344835-iivry1ou	195	86	the	the	DT
cord-344835-iivry1ou	195	87	eosinophil	eosinophil	JJ
cord-344835-iivry1ou	195	88	Mucin	mucin	NN
cord-344835-iivry1ou	195	89	-	-	HYPH
cord-344835-iivry1ou	195	90	producing	produce	VBG
cord-344835-iivry1ou	195	91	elements	element	NNS
cord-344835-iivry1ou	195	92	and	and	CC
cord-344835-iivry1ou	195	93	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	195	94	cells	cell	NNS
cord-344835-iivry1ou	195	95	Effects	effect	NNS
cord-344835-iivry1ou	195	96	of	of	IN
cord-344835-iivry1ou	195	97	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	195	98	cells	cell	NNS
cord-344835-iivry1ou	195	99	on	on	IN
cord-344835-iivry1ou	195	100	neuronal	neuronal	JJ
cord-344835-iivry1ou	195	101	M2	m2	JJ
cord-344835-iivry1ou	195	102	muscarinic	muscarinic	JJ
cord-344835-iivry1ou	195	103	receptor	receptor	NN
cord-344835-iivry1ou	195	104	function	function	NN
cord-344835-iivry1ou	195	105	in	in	IN
cord-344835-iivry1ou	195	106	the	the	DT
cord-344835-iivry1ou	195	107	lung	lung	NN
cord-344835-iivry1ou	195	108	Experimental	experimental	JJ
cord-344835-iivry1ou	195	109	models	model	NNS
cord-344835-iivry1ou	195	110	and	and	CC
cord-344835-iivry1ou	195	111	mechanisms	mechanism	NNS
cord-344835-iivry1ou	195	112	of	of	IN
cord-344835-iivry1ou	195	113	enhanced	enhanced	JJ
cord-344835-iivry1ou	195	114	coughing	cough	VBG
cord-344835-iivry1ou	195	115	Physiological	physiological	JJ
cord-344835-iivry1ou	195	116	changes	change	NNS
cord-344835-iivry1ou	195	117	during	during	IN
cord-344835-iivry1ou	195	118	symptom	symptom	NN
cord-344835-iivry1ou	195	119	recovery	recovery	NN
cord-344835-iivry1ou	195	120	from	from	IN
cord-344835-iivry1ou	195	121	moderate	moderate	JJ
cord-344835-iivry1ou	195	122	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	195	123	of	of	IN
cord-344835-iivry1ou	195	124	COPD	COPD	NNP
cord-344835-iivry1ou	195	125	Lung	Lung	NNP
cord-344835-iivry1ou	195	126	Mechanics	Mechanics	NNPS
cord-344835-iivry1ou	195	127	and	and	CC
cord-344835-iivry1ou	195	128	Dyspnea	Dyspnea	NNP
cord-344835-iivry1ou	195	129	during	during	IN
cord-344835-iivry1ou	195	130	Exacerbations	Exacerbations	NNPS
cord-344835-iivry1ou	195	131	of	of	IN
cord-344835-iivry1ou	195	132	Chronic	Chronic	NNP
cord-344835-iivry1ou	195	133	Obstructive	obstructive	JJ
cord-344835-iivry1ou	195	134	Pulmonary	Pulmonary	NNP
cord-344835-iivry1ou	195	135	Disease	Disease	NNP
cord-344835-iivry1ou	195	136	Mechanisms	Mechanisms	NNPS
cord-344835-iivry1ou	195	137	,	,	,
cord-344835-iivry1ou	195	138	assessment	assessment	NN
cord-344835-iivry1ou	195	139	,	,	,
cord-344835-iivry1ou	195	140	and	and	CC
cord-344835-iivry1ou	195	141	management	management	NN
cord-344835-iivry1ou	195	142	:	:	:
cord-344835-iivry1ou	195	143	a	a	DT
cord-344835-iivry1ou	195	144	consensus	consensus	NN
cord-344835-iivry1ou	195	145	statement	statement	NN
cord-344835-iivry1ou	195	146	Mechanisms	mechanism	NNS
cord-344835-iivry1ou	195	147	of	of	IN
cord-344835-iivry1ou	195	148	worsening	worsen	VBG
cord-344835-iivry1ou	195	149	gas	gas	NN
cord-344835-iivry1ou	195	150	exchange	exchange	NN
cord-344835-iivry1ou	195	151	during	during	IN
cord-344835-iivry1ou	195	152	acute	acute	JJ
cord-344835-iivry1ou	195	153	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	195	154	of	of	IN
cord-344835-iivry1ou	195	155	chronic	chronic	JJ
cord-344835-iivry1ou	195	156	obstructive	obstructive	JJ
cord-344835-iivry1ou	195	157	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	195	158	disease	disease	NN
cord-344835-iivry1ou	195	159	Relationship	relationship	NN
cord-344835-iivry1ou	195	160	between	between	IN
cord-344835-iivry1ou	195	161	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	195	162	oxygen	oxygen	NN
cord-344835-iivry1ou	195	163	consumption	consumption	NN
cord-344835-iivry1ou	195	164	,	,	,
cord-344835-iivry1ou	195	165	lung	lung	NN
cord-344835-iivry1ou	195	166	inflammation	inflammation	NN
cord-344835-iivry1ou	195	167	,	,	,
cord-344835-iivry1ou	195	168	and	and	CC
cord-344835-iivry1ou	195	169	calculated	calculate	VBN
cord-344835-iivry1ou	195	170	venous	venous	JJ
cord-344835-iivry1ou	195	171	admixture	admixture	NN
cord-344835-iivry1ou	195	172	in	in	IN
cord-344835-iivry1ou	195	173	patients	patient	NNS
cord-344835-iivry1ou	195	174	with	with	IN
cord-344835-iivry1ou	195	175	acute	acute	JJ
cord-344835-iivry1ou	195	176	lung	lung	NN
cord-344835-iivry1ou	195	177	injury	injury	NN
cord-344835-iivry1ou	196	1	The	the	DT
cord-344835-iivry1ou	196	2	role	role	NN
cord-344835-iivry1ou	196	3	of	of	IN
cord-344835-iivry1ou	196	4	corticosteroids	corticosteroid	NNS
cord-344835-iivry1ou	196	5	in	in	IN
cord-344835-iivry1ou	196	6	chronic	chronic	JJ
cord-344835-iivry1ou	196	7	obstructive	obstructive	JJ
cord-344835-iivry1ou	196	8	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	196	9	disease	disease	NN
cord-344835-iivry1ou	196	10	.	.	.
cord-344835-iivry1ou	197	1	Semin	Semin	NNP
cord-344835-iivry1ou	197	2	Respir	Respir	NNP
cord-344835-iivry1ou	198	1	Crit	Crit	NNP
cord-344835-iivry1ou	198	2	Care	Care	NNP
cord-344835-iivry1ou	198	3	Med	Med	NNP
cord-344835-iivry1ou	198	4	Oral	oral	JJ
cord-344835-iivry1ou	198	5	corticosteroids	corticosteroid	NNS
cord-344835-iivry1ou	198	6	for	for	IN
cord-344835-iivry1ou	198	7	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	198	8	of	of	IN
cord-344835-iivry1ou	198	9	chronic	chronic	JJ
cord-344835-iivry1ou	198	10	obstructive	obstructive	JJ
cord-344835-iivry1ou	198	11	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	198	12	disease	disease	NN
cord-344835-iivry1ou	199	1	Oral	oral	JJ
cord-344835-iivry1ou	199	2	corticosteroids	corticosteroid	NNS
cord-344835-iivry1ou	199	3	in	in	IN
cord-344835-iivry1ou	199	4	patients	patient	NNS
cord-344835-iivry1ou	199	5	admitted	admit	VBN
cord-344835-iivry1ou	199	6	to	to	IN
cord-344835-iivry1ou	199	7	hospital	hospital	NN
cord-344835-iivry1ou	199	8	with	with	IN
cord-344835-iivry1ou	199	9	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	199	10	of	of	IN
cord-344835-iivry1ou	199	11	chronic	chronic	JJ
cord-344835-iivry1ou	199	12	obstructive	obstructive	JJ
cord-344835-iivry1ou	199	13	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	199	14	disease	disease	NN
cord-344835-iivry1ou	199	15	:	:	:
cord-344835-iivry1ou	199	16	a	a	DT
cord-344835-iivry1ou	199	17	prospective	prospective	JJ
cord-344835-iivry1ou	199	18	randomised	randomise	VBN
cord-344835-iivry1ou	199	19	controlled	control	VBN
cord-344835-iivry1ou	199	20	trial	trial	NN
cord-344835-iivry1ou	199	21	Effect	effect	NN
cord-344835-iivry1ou	199	22	of	of	IN
cord-344835-iivry1ou	199	23	systemic	systemic	JJ
cord-344835-iivry1ou	199	24	glucocorticoids	glucocorticoid	NNS
cord-344835-iivry1ou	199	25	on	on	IN
cord-344835-iivry1ou	199	26	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	199	27	of	of	IN
cord-344835-iivry1ou	199	28	chronic	chronic	JJ
cord-344835-iivry1ou	199	29	obstructive	obstructive	JJ
cord-344835-iivry1ou	199	30	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	199	31	disease	disease	NN
cord-344835-iivry1ou	199	32	.	.	.
cord-344835-iivry1ou	200	1	Department	Department	NNP
cord-344835-iivry1ou	200	2	of	of	IN
cord-344835-iivry1ou	200	3	Veterans	Veterans	NNP
cord-344835-iivry1ou	200	4	Affairs	Affairs	NNPS
cord-344835-iivry1ou	200	5	Cooperative	Cooperative	NNP
cord-344835-iivry1ou	200	6	Study	Study	NNP
cord-344835-iivry1ou	200	7	Group	Group	NNP
cord-344835-iivry1ou	200	8	Systemic	systemic	JJ
cord-344835-iivry1ou	200	9	corticosteroids	corticosteroid	NNS
cord-344835-iivry1ou	200	10	for	for	IN
cord-344835-iivry1ou	200	11	acute	acute	JJ
cord-344835-iivry1ou	200	12	exacerbations	exacerbation	NNS
cord-344835-iivry1ou	200	13	of	of	IN
cord-344835-iivry1ou	200	14	chronic	chronic	JJ
cord-344835-iivry1ou	200	15	obstructive	obstructive	JJ
cord-344835-iivry1ou	200	16	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	200	17	disease	disease	NN
cord-344835-iivry1ou	200	18	Corticosteroid	Corticosteroid	NNP
cord-344835-iivry1ou	200	19	resistance	resistance	NN
cord-344835-iivry1ou	200	20	in	in	IN
cord-344835-iivry1ou	200	21	airway	airway	NN
cord-344835-iivry1ou	200	22	disease	disease	NN
cord-344835-iivry1ou	200	23	Sputum	Sputum	NNP
cord-344835-iivry1ou	200	24	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	200	25	and	and	CC
cord-344835-iivry1ou	200	26	short	short	JJ
cord-344835-iivry1ou	200	27	-	-	HYPH
cord-344835-iivry1ou	200	28	term	term	NN
cord-344835-iivry1ou	200	29	response	response	NN
cord-344835-iivry1ou	200	30	to	to	IN
cord-344835-iivry1ou	200	31	prednisolone	prednisolone	NN
cord-344835-iivry1ou	200	32	in	in	IN
cord-344835-iivry1ou	200	33	chronic	chronic	JJ
cord-344835-iivry1ou	200	34	obstructive	obstructive	JJ
cord-344835-iivry1ou	200	35	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	200	36	disease	disease	NN
cord-344835-iivry1ou	200	37	:	:	:
cord-344835-iivry1ou	200	38	a	a	DT
cord-344835-iivry1ou	200	39	randomised	randomised	JJ
cord-344835-iivry1ou	200	40	controlled	control	VBN
cord-344835-iivry1ou	200	41	trial	trial	NN
cord-344835-iivry1ou	200	42	Bradding	Bradding	NNP
cord-344835-iivry1ou	200	43	P	P	NNP
cord-344835-iivry1ou	200	44	:	:	:
cord-344835-iivry1ou	201	1	Sputum	Sputum	NNP
cord-344835-iivry1ou	201	2	eosinophilia	eosinophilia	NN
cord-344835-iivry1ou	201	3	and	and	CC
cord-344835-iivry1ou	201	4	the	the	DT
cord-344835-iivry1ou	201	5	short	short	JJ
cord-344835-iivry1ou	201	6	term	term	NN
cord-344835-iivry1ou	201	7	response	response	NN
cord-344835-iivry1ou	201	8	to	to	IN
cord-344835-iivry1ou	201	9	inhaled	inhale	VBN
cord-344835-iivry1ou	201	10	mometasone	mometasone	NN
cord-344835-iivry1ou	201	11	in	in	IN
cord-344835-iivry1ou	201	12	chronic	chronic	JJ
cord-344835-iivry1ou	201	13	obstructive	obstructive	JJ
cord-344835-iivry1ou	201	14	pulmonary	pulmonary	JJ
cord-344835-iivry1ou	201	15	disease	disease	NN
cord-344835-iivry1ou	201	16	.	.	.
cord-344835-iivry1ou	202	1	Thorax	Thorax	NNP
cord-344835-iivry1ou	202	2	Effect	effect	NN
cord-344835-iivry1ou	202	3	of	of	IN
cord-344835-iivry1ou	202	4	beta	beta	NN
cord-344835-iivry1ou	202	5	-	-	HYPH
cord-344835-iivry1ou	202	6	agonists	agonist	NNS
cord-344835-iivry1ou	202	7	on	on	IN
cord-344835-iivry1ou	202	8	inflammatory	inflammatory	JJ
cord-344835-iivry1ou	202	9	cells	cell	NNS
cord-344835-iivry1ou	203	1	The	the	DT
cord-344835-iivry1ou	203	2	author(s	author(s	NNP
cord-344835-iivry1ou	203	3	)	)	-RRB-
cord-344835-iivry1ou	203	4	declare	declare	VBP
cord-344835-iivry1ou	203	5	that	that	IN
cord-344835-iivry1ou	203	6	they	-PRON-	PRP
cord-344835-iivry1ou	203	7	have	have	VBP
cord-344835-iivry1ou	203	8	no	no	DT
cord-344835-iivry1ou	203	9	competing	compete	VBG
cord-344835-iivry1ou	203	10	interests	interest	NNS
cord-344835-iivry1ou	203	11	.	.	.
cord-344835-iivry1ou	204	1	Publish	publish	VB
cord-344835-iivry1ou	204	2	with	with	IN
cord-344835-iivry1ou	204	3	Bio	Bio	NNP
cord-344835-iivry1ou	204	4	Med	Med	NNP
cord-344835-iivry1ou	204	5	Central	Central	NNP
cord-344835-iivry1ou	204	6	and	and	CC
cord-344835-iivry1ou	204	7	every	every	DT
cord-344835-iivry1ou	204	8	scientist	scientist	NN
cord-344835-iivry1ou	204	9	can	can	MD
cord-344835-iivry1ou	204	10	read	read	VB
cord-344835-iivry1ou	204	11	your	-PRON-	PRP$
cord-344835-iivry1ou	204	12	work	work	NN
cord-344835-iivry1ou	204	13	free	free	JJ
cord-344835-iivry1ou	204	14	of	of	IN
cord-344835-iivry1ou	204	15	charge	charge	NN
cord-344835-iivry1ou	204	16	 	 	_SP