id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-024317-w1ep0wq8	Ku, Zhiqiang	Antibody therapies for the treatment of COVID-19	2020-04-30		.txt	text/plain	2215	152	47	Here, we discuss some of the most active areas of developing strategies to treat COVID-19, focusing on approaches to generate neutralizing antibodies against SARS-CoV-2 for prophylactic and therapeutic treatment of COVID-19. SIGNIFICANCE: Development of SARS-CoV-2 neutralizing antibodies with the desired efficacy and safety profile is a critical part of the toolbox of therapies for the treatment of COVID-19. The spike protein of SARS-CoV-2 plays an essential role in virus entry into host cells and is a primary target of neutralizing antibodies 5, 9 (Figures 1C,D) . Two MERS-CoV neutralizing mAbs, G2 and 7D10, target the S1-NTD region and function by blocking spike protein interaction with the host receptor DPP4 47, 48 . In the monkey study, researchers found that rhesus macaques infected with SARS-CoV-2 through the intratracheal route had mild illness, and their lungs showed signs of pneumonia similar to those in humans with COVID-19 58 .	./cache/cord-024317-w1ep0wq8.txt	./txt/cord-024317-w1ep0wq8.txt